title: [Screening for lifespan-extension mutants with paraquat in Arabidopsis].
abstract: Genetic analyses of lifespan in model animals have revealed that extended lifespans are closely associated to increased resistance to oxidative stress. In the model plant Arabidopsis, late-flowering mutants are also found to be more tolerant to oxidative stress. However, Arabidopsis mutants with extended lifespans are poorly studied so far. In this study, a screening system for mutants with extended lifespans in Arabidopsis was established using paraquat, a potent herbicide that exacerbates O2-. radical production. The relationship between lifespan and resistance to oxidative stress was examined with one of the mutants, SFNA-9-4. Compared to that of wild type, the lifespan of SFNA-9-4 is significantly extended, and its resistance to oxidative stress is also significantly elevated. These results suggest that, as in Drosophila, paraquat can also be used to screen for mutants with extended lifespans in Arabidopsis.
authors.affiliation: Department of Biochemistry, School of Life Sciences, Fudan University, China.
authors.forename: Shu Qing
authors.initials: SQ
authors.lastname: Cao
authors.forename: Qiao Ting
authors.initials: QT
authors.lastname: Xu
authors.forename: Hong Jun
authors.initials: HJ
authors.lastname: Zhou
authors.forename: Ya Jun
authors.initials: YJ
authors.lastname: Cao
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhu
authors.forename: Fang
authors.initials: F
authors.lastname: Yu
authors.forename: Ben Ke
authors.initials: BK
authors.lastname: Kuai
mesh_terms: D000818:Animals; D017360:Arabidopsis / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development*; D004330:Drosophila / Q000235:genetics; D018506:Gene Expression Regulation, Plant; D006540:Herbicides / Q000494:pharmacology; D009154:Mutation; D018384:Oxidative Stress; D010269:Paraquat / Q000494:pharmacology*
chemical_list: D006540:Herbicides; D010269:Paraquat