title: Cholesteryl glucoside-induced protection against gastric ulcer.
abstract: The cytoprotective effect of heat shock proteins (HSPs) promises new therapeutic modalities for medical treatment. We examined the anti-ulcer effect of cholesteryl glucoside (1-O-cholesteryl-beta-D-glucopyranoside, CG) on cold-restraint stress-induced gastric ulcer in rats, in terms of its correlative ability to activate heat shock factor (HSF) and to induce HSP70. Rapid induction of CG occurred in animal tissues, especially in stomach, after exposure to stress, indicating that this glycolipid might act as an anti-stress, lipid mediator involved in the very early stages of stress-induced signal transduction. Orally administered CG apparently showed anti-ulcer activity in rats via HSF activation and HSP70 induction. When compared with geranylgeranylacetone (GGA), the well known as an effective, synthetic anti-ulcer agent, CG proved to have the same level of strength on ulcer inhibition. GGA caused CG and HSP70 induction in gastric mucosa, indicating that GGA induced HSP70 via CG production. CG thus might be useful for medical treatment of stress-induced diseases, and as an anti-stress supplement for daily diet.
authors.affiliation: Department of Biology, Faculty of Science, Ochanomizu University, Tokyo 112-8610, Japan.
authors.forename: Shohko
authors.initials: S
authors.lastname: Kunimoto
authors.forename: Wataru
authors.initials: W
authors.lastname: Murofushi
authors.forename: Isao
authors.initials: I
authors.lastname: Yamatsu
authors.forename: Yukie
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Narie
authors.initials: N
authors.lastname: Sasaki
authors.forename: Susumu
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Tetsuyuki
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Hiromu
authors.initials: H
authors.lastname: Murofushi
authors.forename: Kimiko
authors.initials: K
authors.lastname: Murakami-Murofushi
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000378:metabolism* / Q000627:therapeutic use; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000627:therapeutic use; D004224:Diterpenes / Q000378:metabolism / Q000627:therapeutic use; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D015394:Molecular Structure; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000188:drug therapy / Q000378:metabolism*; D013315:Stress, Psychological; D013696:Temperature
chemical_list: D000897:Anti-Ulcer Agents; D004224:Diterpenes; D018840:HSP70 Heat-Shock Proteins; C027578:cholesteryl glucoside; D002784:Cholesterol; C031049:geranylgeranylacetone