title: Helicobacter pylori eradication is beneficial in the treatment of functional dyspepsia.
abstract: OBJECTIVE
  To assess whether the eradication of Helicobacter pylori leads to long-term relief of symptoms in functional dyspepsia.
  
  
  METHODS
  Eight hundred patients with functional dyspepsia were randomized to receive double-blind treatment with twice-daily 30 mg lansoprazole, 1000 mg amoxicillin and 500 mg clarithromycin for 7 days (L30AC), twice-daily 15 mg lansoprazole, 1000 mg amoxicillin and 500 mg clarithromycin for 7 days (L15AC), or once-daily 15 mg lansoprazole for 14 days (LP). Dyspepsia and reflux symptoms were monitored for 12 months.
  
  
  RESULTS
  In intention-to-treat analysis, the non-ulcer dyspepsia sum score showed a statistically significant benefit in terms of symptom relief in the L30AC group (P = 0.0068) compared with the LP group, but there was no significant difference between the L15AC and LP groups (P = 0.2). When all patients in the two eradication therapy arms were considered together, successful eradication had a significant benefit with regard to the complete absence of symptoms (P < 0.04). H. pylori eradication did not lead to an increase in reflux symptoms.
  
  
  CONCLUSIONS
  This study suggests that H. pylori infection causes dyspeptic symptoms in a subset of patients with functional dyspepsia, and that these patients may obtain long-term symptomatic benefit following H. pylori eradication.
authors.affiliation: Otto-von-Guericke-Universität, Zentrum für Innere Medizin, Magdeburg, Germany. peter.malfertheiner@medizin.uni-magdeburg.de
authors.forename: P
authors.initials: P
authors.lastname: Malfertheiner
authors.forename: J
authors.initials: J
authors.lastname: MOssner
authors.forename: W
authors.initials: W
authors.lastname: Fischbach
authors.forename: P
authors.initials: P
authors.lastname: Layer
authors.forename: A
authors.initials: A
authors.lastname: Leodolter
authors.forename: M
authors.initials: M
authors.lastname: Stolte
authors.forename: K
authors.initials: K
authors.lastname: Demleitner
authors.forename: W
authors.initials: W
authors.lastname: Fuchs
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000293:Adolescent; D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D017291:Clarithromycin / Q000008:administration & dosage; D004311:Double-Blind Method; D004359:Drug Therapy, Combination / Q000008:administration & dosage; D004415:Dyspepsia / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D064747:Lansoprazole; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage / Q000031:analogs & derivatives; D010406:Penicillins / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000900:Anti-Bacterial Agents; D010406:Penicillins; D064747:Lansoprazole; D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole