Role of genetics in prevention of coronary atherosclerosis.
Atherosclerosis is currently regarded as a complex disorder, triggered by gene-gene and gene-environment interactions. Despite the difficulties of multifactorial disease genetic analysis, significant progress has been achieved in the search for atherosclerosis susceptibility genes. Here, we review these advances with regard to genome scan results and candidate gene analysis.
Novelli
Giuseppe
G
Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, School of Medicine, Tor Vergata University of Rome, Rome, Italy. novelli@med.uniroma2.it
Borgiani
Paola
P
Giardina
Emiliano
E
Mango
Ruggiero
R
Contino
Gianmarco
G
Romeo
Francesco
F
Mehta
J L
JL
D003324:Coronary Artery Disease / Q000235:genetics* / Q000517:prevention & control*; D003331:Coronary Vessels / Q000503:physiopathology; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D020412:Multifactorial Inheritance / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors