Role of follicle-stimulating hormone receptor Ser680Asn polymorphism in the efficacy of follicle-stimulating hormone.
OBJECTIVE
To evaluate the association between FSH efficacy and FSHR alleles.


METHODS
Retrospective study.


METHODS
University-based fertility unit and a private center for biomedical research.


METHODS
One hundred two women with ovarian function who were undergoing controlled ovarian stimulation (COS). Women were categorized as poor responders (< or =3 ovarian follicles at the end of the cycle) or normal responders (>3 follicles).


METHODS
Daily administration of exogenous FSH.


METHODS
Number of good or poor responders.


RESULTS
The allele frequency and genotype distribution of the Ser680Asn marker differed significantly between groups. Cycle cancellations were increased (21%) among women who were homozygous for Ser680 compared with Ser/Asn and Asn/Asn patients, and 36% of poor-responders were homozygous for Ser680.


CONCLUSIONS
The results support a role for FSHR gene in COS outcome. However, the weight of this factor is probably low. The Ser680 allele may act in concert with other environmental and genetic factors that contribute to FSH efficacy.
de Castro
Francisco
F
Unidad de Reproducción Humana Asistida, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
Ruiz
Rocío
R
Montoro
Luis
L
Pérez-Hernández
Dámaso
D
Sánchez-Casas Padilla
Elisa
E
Real
Luis M
LM
Ruiz
Agustín
A
D000328:Adult; D000483:Alleles; D000595:Amino Acid Sequence / Q000235:genetics; D001216:Asparagine; D004334:Drug Administration Schedule; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D005787:Gene Frequency; D005819:Genetic Markers; D006720:Homozygote; D006801:Humans; D010062:Ovulation Induction; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000502:physiology*; D011962:Receptors, FSH / Q000235:genetics*; D011994:Recombinant Proteins / Q000008:administration & dosage; D012189:Retrospective Studies; D012694:Serine; D016896:Treatment Outcome
D005819:Genetic Markers; D011962:Receptors, FSH; D011994:Recombinant Proteins; D012694:Serine; D001216:Asparagine; D005640:Follicle Stimulating Hormone