title: Myocarditis and abortion associated with intrauterine infection of sows with porcine circovirus 2.
abstract: Porcine circovirus 2 (PCV2) is a recently identified agent that has been associated with postweaning multisystemic wasting syndrome (PMWS) in swine populations. In this report, the potential spectrum of disease associated with PCV2 is expanded by evidence of vertical transmission and associated reproductive failure. PCV2 was isolated from a litter of aborted piglets from a farm experiencing late-term abortions and stillbirths. Severe, diffuse myocarditis was present in 1 piglet associated with extensive immunohistochemical staining for PCV2 antigen. Variable amounts of PCV2 antigen were also present in liver, lung, and kidney of multiple fetuses. The presence of other agents that have been associated with fetal lesions and abortion in swine, including porcine parvovirus, porcine reproductive respiratory syndrome virus, encephalomyocarditis virus, and enterovirus, could not be established.
authors.affiliation: Prairie Diagnostic Service, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan S7N 5B4, Canada.
authors.forename: K H
authors.initials: KH
authors.lastname: West
authors.forename: J M
authors.initials: JM
authors.lastname: Bystrom
authors.forename: C
authors.initials: C
authors.lastname: Wojnarowicz
authors.forename: N
authors.initials: N
authors.lastname: Shantz
authors.forename: M
authors.initials: M
authors.lastname: Jacobson
authors.forename: G M
authors.initials: GM
authors.lastname: Allan
authors.forename: D M
authors.initials: DM
authors.lastname: Haines
authors.forename: E G
authors.initials: EG
authors.lastname: Clark
authors.forename: S
authors.initials: S
authors.lastname: Krakowka
authors.forename: F
authors.initials: F
authors.lastname: McNeilly
authors.forename: C
authors.initials: C
authors.lastname: Konoby
authors.forename: K
authors.initials: K
authors.lastname: Martin
authors.forename: J A
authors.initials: JA
authors.lastname: Ellis
mesh_terms: D000034:Abortion, Veterinary / Q000821:virology*; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D018173:Circoviridae Infections / Q000150:complications / Q000635:transmission / Q000662:veterinary*; D017925:Circovirus / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D005260:Female; D005313:Fetal Death / Q000662:veterinary / Q000821:virology; D018445:Infectious Disease Transmission, Vertical / Q000662:veterinary*; D009205:Myocarditis / Q000662:veterinary* / Q000821:virology; D011247:Pregnancy; D013553:Swine Diseases / Q000473:pathology / Q000821:virology*
chemical_list: D000956:Antigens, Viral