title: Frontal lobe dysfunction caused by multiple lacunar infarction in community-dwelling elderly subjects.
abstract: We examined the factors that influence frontal lobe function among 119 community-dwelling elderly subjects, based on magnetic resonance imaging (MRI) and clinical findings. We interviewed the subjects, and conducted a neurological examination, electrocardiogram, blood test, brain MRI examination, and cognitive function tests. The modified Stroop test and a personal computer version of the Wisconsin Card Sorting Test (WCST) were used to evaluate frontal lobe function. The subjects with impaired frontal lobe function defined by the modified Stroop test were significantly older, had more lacunar infarcts, and had lower HDL cholesterol values based on a logistic regression model. Among the aged who appear apparently normal, multiple lacunar infarcts are the cause of latent frontal lobe dysfunction.
authors.affiliation: Center for Emotional and Behavioral Disorder, Hizen National Hospital, Kanzaki, Saga 842-0192, Japan. taka@hizen2.hosp.go.jp
authors.forename: Yuki
authors.initials: Y
authors.lastname: Takashima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yao
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Koga
authors.forename: Koichi
authors.initials: K
authors.lastname: Endo
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Akira
authors.initials: A
authors.lastname: Uchino
authors.forename: Fumiko
authors.initials: F
authors.lastname: Sadanaga-Akiyoshi
authors.forename: Takefumi
authors.initials: T
authors.lastname: Yuzuriha
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Kuroda
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D020520:Brain Infarction / Q000097:blood / Q000150:complications* / Q000523:psychology; D008076:Cholesterol, HDL / Q000097:blood; D003072:Cognition Disorders / Q000097:blood / Q000209:etiology* / Q000523:psychology; D005260:Female; D005625:Frontal Lobe / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009483:Neuropsychological Tests
chemical_list: D008076:Cholesterol, HDL