[The research on IR and TEM of polybutylcyanoacrylate nanoparticles].
Through latex polymerization with stabilizer (Dextran, low fraction), we prepared polybutylcyanoacrylate nanoparticles with a size of approximately 200 nm. The nanoparticle diameter decreases with decreasing stabilizer concentration. Using TEM and IR we studied the combination state and the mechanism between polybutylcyanoacrylate and Dextran. It was shown that each Dextran molecule could therefore contain several cyanoacrylate polymer moieties covalently linked via any of the available Dextran hydroxyl groups. Anchoring of the cyanoacrylate groups within the nanoparticle matrix would therefore result in an irreversible attachment between the Dextran and the nanoparticle. In this way, Dextran could be incorporated throughout the particle matrix as well as on the surface, producing the biodegradable particle. The results have been interpreted by reference to the accepted theories of steric stabilization and dispersion polymerization, and a model is proposed for the nanoparticle formation in the presence of Dextran.
Li
Xin
X
Department of Chemistry, Tsinghua University, Beijing 100084, China.
Zhu
Yong-fa
YF
Zhao
Mei-juan
MJ
D001672:Biocompatible Materials; D003911:Dextrans / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D004355:Drug Stability; D004659:Enbucrilate / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D036103:Nanotechnology; D010316:Particle Size; D013055:Spectrophotometry, Infrared / Q000379:methods
D001672:Biocompatible Materials; D003911:Dextrans; D004337:Drug Carriers; D004659:Enbucrilate