A potential new use for gonadotropin-releasing hormone antagonists.
OBJECTIVE
To describe a potential new use of gonadotropin-releasing hormone (GnRH) antagonists.


METHODS
Case report.


METHODS
Assisted conception unit at a teaching hospital in the United Kingdom.


METHODS
A 37-year-old woman undergoing in vitro fertilization (IVF) who accidentally stopped using GnRH agonists after starting ovarian stimulation.


METHODS
A GnRH antagonist was used to avoid a luteinizing hormone (LH) surge and hence "rescue" the cycle.


RESULTS
Successful oocyte retrieval was carried out, two embryos transferred, and a viable twin pregnancy ensued.


CONCLUSIONS
This may be a new indication for the use of GnRH antagonists.
Aust
Thomas R
TR
Department of Reproductive Medicine, Liverpool Women's Hospital, Liverpool, United Kingdom. tomaust@doctors.org.uk
Sklavounos
John
J
Kingsland
Charles R
CR
Gazvani
Rafet
R
D000059:Accidents; D000328:Adult; D002064:Buserelin / Q000008:administration & dosage*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000037:antagonists & inhibitors*; D006801:Humans; D007986:Luteinizing Hormone / Q000037:antagonists & inhibitors; D008297:Male; D009865:Oocytes; D010349:Patient Compliance; D011247:Pregnancy; D011272:Pregnancy, Multiple; D020554:Sperm Injections, Intracytoplasmic; D020858:Tissue and Organ Harvesting; D014427:Twins
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D002064:Buserelin