Epithelial migration: open your eyes to c-Jun.
Tissue-specific removal of c-jun from epidermal cells in mice leads to a failure of eyelid fusion during embryogenesis and reveals roles for c-Jun in wound repair and tumorigenesis in adult skin. This has provided a definitive test of the in vivo function of AP-1 signalling and shown that EGF signalling is key to all of c-Jun's roles in the epidermis.
Grose
Richard
R
Viral Carcinogenesis Laboratory, Cancer Research UK London Research Institute, 61 Lincoln's Inn Fields, WC2A 3PX, London, UK. richard.grose@cancer.org.uk
D000818:Animals; D004815:Epidermal Growth Factor / Q000502:physiology*; D004817:Epidermis / Q000502:physiology*; D004848:Epithelium / Q000502:physiology; D005143:Eyelids / Q000502:physiology; D025461:Feedback, Physiological / Q000502:physiology; D016758:Genes, jun / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D015398:Signal Transduction / Q000502:physiology*; D018808:Transcription Factor AP-1 / Q000502:physiology*
D018808:Transcription Factor AP-1; D004815:Epidermal Growth Factor