Brachial artery: measurement of flow-mediated dilatation with cross-sectional US--technical validation.
Ultrasonographic examination of flow phantoms and the brachial artery of a healthy volunteer undergoing reactive hyperemia was performed. Images were analyzed with a user-guided automated boundary detection (UGABD) algorithm to extract boundaries and measure cross-sectional area. UGABD correctly detected pulsatile vasomotion and measured area within 5% of the true value. A comparison of UGABD versus manual tracing yielded linear correlation of 0.81-0.91. Peak vasodilatation measured in response to reactive hyperemia was 150 times greater in pixel count than that measured with longitudinal imaging. Cross-sectional imaging is more sensitive than longitudinal imaging for measuring flow-mediated dilatation of the brachial artery.
Kao
Yen Hong
YH
Department of Radiology, University of Pennsylvania Medical Center, 1 Silverstein, 3400 Spruce St, Philadelphia, PA 19104, USA.
Mohler
Emile R
ER
Arger
Peter H
PH
Sehgal
Chandra M
CM
D000465:Algorithms; D001916:Brachial Artery / Q000000981:diagnostic imaging* / Q000502:physiology*; D006801:Humans; D019047:Phantoms, Imaging; D011673:Pulsatile Flow / Q000502:physiology; D012680:Sensitivity and Specificity; D014463:Ultrasonography; D014664:Vasodilation / Q000502:physiology