Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-I-converting enzyme deletion/deletion genotype.
In patients with hypertension who have the DD-ACE genotype (higher angiotensin-converting enzyme [ACE] activity), plasma levels of angiotensin-(1-7) are 4 times lower than in patients with the II-ACE genotype (lower ACE levels). Angiotensin II levels are similar in both groups.
Jalil
Jorge E
JE
Department of Cardiovascular Diseases, Medical School, Pontifica Catholic University of Chile, Marcoleta 367, Room 19, Santiago, Chile. jjalil@med.puc.cl
Palomera
Cristián
C
Ocaranza
María Paz
MP
Godoy
Iván
I
Román
Maritza
M
Chiong
Mario
M
Lavandero
Sergio
S
D000328:Adult; D000803:Angiotensin I / Q000097:blood*; D000804:Angiotensin II / Q000097:blood; D000959:Antihypertensive Agents / Q000097:blood*; D005260:Female; D017353:Gene Deletion; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D014662:Vasoconstrictor Agents / Q000097:blood
D000959:Antihypertensive Agents; D010446:Peptide Fragments; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D000803:Angiotensin I; D007703:Peptidyl-Dipeptidase A; C118790:angiotensin I (1-7)