title: Optimal scan time for evaluating pancreatic disease with positron emission tomography using F-18-fluorodeoxyglucose.
abstract: OBJECTIVE
  Image interpretation in positron emission tomography (PET) using F-18-fluoro-2-deoxy-D-glucose (FDG) is usually performed for images obtained at 1 h postinjection (PI) of FDG, but it remains unknown whether this is the optimal time for imaging patients with pancreatic disease. The aim of this study was to assess the optimal scan time for FDG-PET for patients suspected of having pancreatic cancer.
  
  
  METHODS
  Forty-four patients with suspected pancreatic cancer underwent FDG-PET scans at both 1 h and 2 h PI. Tracer uptake in the pancreatic lesions and possible liver metastasis was interpreted qualitatively, using a 5-point grading system (0 = normal, 1 = probably normal, 2 = equivocal, 3 = probably abnormal, and 4 = definitely abnormal) by 4 nuclear medicine physicians independently, who were blind to all clinical information. Detection performance with each image was compared using receiver operating characteristic (ROC) analysis. An average score of the 4 readers for each patient was also defined as consensus average index (CAI) and compared between the two images.
  
  
  RESULTS
  ROC results indicated no significant differences in detection performance (Averaged areas under ROC curves of 1 h vs. 2 h were 0.92 vs. 0.90 for primary tumor, and 0.81 vs. 0.85 for liver metastases). There were no significant differences in CAIs between 1 h and 2 h PI images in interpreting primary tumor and positive liver metastases, but a significant difference was observed for cases without liver metastases (p < 0.05).
  
  
  CONCLUSIONS
  The certainty of excluding liver metastases was increased when the 2h image was used, although ROC analysis did not establish a difference between 1 h and 2 h imaging for differentiating malignant and benign lesions in primary pancreatic cancer or its liver metastases.
authors.affiliation: Department of Nuclear Medicine and Diagnostic Imaging, Graduate School of Medicine, Kyoto University, Japan. ynakamoto@ibri-kobe.org
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nakamoto
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Saga
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Higashi
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Ishimori
authors.forename: Hisataka
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Koichi
authors.initials: K
authors.lastname: Ishizu
authors.forename: Noriko
authors.initials: N
authors.lastname: Sato
authors.forename: Marcelo
authors.initials: M
authors.lastname: Mamede
authors.forename: Harumi
authors.initials: H
authors.lastname: Sakahara
authors.forename: Masayuki
authors.initials: M
authors.lastname: Imamura
authors.forename: Junji
authors.initials: J
authors.lastname: Konishi
mesh_terms: D005189:False Positive Reactions; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007089:Image Enhancement; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18