title: Lack of association between the 5HT2A receptor polymorphism (T102C) and unipolar affective disorder in a multicentric European study.
abstract: We report here a case-control association study with T102C polymorphism in the serotonin 2A receptor gene (HTR2A) in patients affected by unipolar affective disorder (UPAD) and in controls. A total of 284 subjects were genotyped (142 UPAD and 142 controls). All subjects were interviewed using standard diagnostic interviews and matched. A homogenous population of unipolar patients with suicidal attempt was identified. Conditional logistic regression was applied. No association of the HTR2A polymorphism was found in the overall sample of 142 UPAD-control pairs regarding allele and genotype frequencies (P=0.36 and P=0.52 respectively) and homo-heterozygote distributions (P=0.91). This study confirms, in a multicentric European sample, the earlier observations that the T102C HTR2A polymorphism is not associated with UPAD. Nevertheless, a type 2 statistical error cannot be excluded. Therefore, to exclude the implication of HTR2A in UPAD, this result must be replicated in larger samples and in other populations using the transmission disequilibrium test and different polymorphisms around HTR2A.
authors.affiliation: University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Brussels, Belgium. poswald@ulb.ac.be
authors.forename: Pierre
authors.initials: P
authors.lastname: Oswald
authors.forename: Daniel
authors.initials: D
authors.lastname: Souery
authors.forename: Isabelle
authors.initials: I
authors.lastname: Massat
authors.forename: Jurgen
authors.initials: J
authors.lastname: Del-Favero
authors.forename: Sylvie
authors.initials: S
authors.lastname: Linotte
authors.forename: George
authors.initials: G
authors.lastname: Papadimitriou
authors.forename: Dimitris
authors.initials: D
authors.lastname: Dikeos
authors.forename: Radka
authors.initials: R
authors.lastname: Kaneva
authors.forename: Vibra
authors.initials: V
authors.lastname: Milanova
authors.forename: Lilijana
authors.initials: L
authors.lastname: Oruc
authors.forename: Sladana
authors.initials: S
authors.lastname: Ivezic
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
authors.forename: Roberta
authors.initials: R
authors.lastname: Lilli
authors.forename: Christine
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: Julien
authors.initials: J
authors.lastname: Mendlewicz
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D016001:Confidence Intervals; D003866:Depressive Disorder / Q000235:genetics*; D005060:Europe; D005787:Gene Frequency / Q000235:genetics; D006801:Humans; D016015:Logistic Models; D019964:Mood Disorders / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin