title: Effect of 3.2 vs. 3.8% sodium citrate concentration on anti-Xa levels for patients on therapeutic low molecular weight heparin.
abstract: In this study, we compared the effect of sodium citrate, a sample collection variable, on the anti-Xa levels of patients (n = 28) on dalteparin, a low molecular weight heparin. The median anti-Xa level for 3.2% sodium citrate was 0.235 U/ml while the median level for 3.8% sodium citrate was 0.230 U/ml. We conclude that different sodium citrate concentrations give statistically equivalent anti-Xa levels for the same samples. This conclusion is in contrast to the findings of the effect of sodium citrate concentration on International Normalized Ratio (INR) and activated partial-thromboplastin time (aPTT). In accordance with previous recommendations, we advocate the exclusive use of 3.2% sodium citrate in an effort to standardize coagulation testing.
authors.affiliation: Unversity of Western Ontario, Ontario, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Payne
authors.forename: K
authors.initials: K
authors.lastname: MacKinnon
authors.forename: M
authors.initials: M
authors.lastname: Keeney
authors.forename: B
authors.initials: B
authors.lastname: Morrow
authors.forename: M J
authors.initials: MJ
authors.lastname: Kovacs
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D001780:Blood Coagulation Tests / Q000592:standards; D002951:Citrates / Q000494:pharmacology*; D017985:Dalteparin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006801:Humans; D000077559:Sodium Citrate; D020246:Venous Thrombosis / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; D002951:Citrates; D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents; D000077559:Sodium Citrate; D017985:Dalteparin