Are NKT cells essential for endotoxic shock?
Endotoxic shock is a major health threat caused by gram-negative bacteria and their unique cell wall component, lipopolysaccharide, which induces exaggerated production of proinflammatory cytokines. Although macrophages play a central role in the pathogenesis of endotoxic shock, natural killer (NK)1+ cells are also involved in this mechanism. NK1+ cells comprise two major populations, namely NK cells and NKT cells. It remains, however, elusive whether NK cells, NKT cells or both are involved in the induction of endotoxic shock. This review will focus on the relative contribution of these NK1+ cells to the pathogenesis of endotoxic shock.
Emoto
Masashi
M
Department of Immunology, Max-Planck-Institute for Infection Biology, Berlin, Germany. emoto@mpiib-berlin.mpg.de
D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000276:immunology; D008099:Liver / Q000473:pathology; D012772:Shock, Septic / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines; D008070:Lipopolysaccharides; D007371:Interferon-gamma