title: [Histologic and prognostic study of nephroblastoma in central Tunisia].
abstract: Nephroblastoma is a common malignant tumour in childhood that benefited from therapeutic progress. This is a retrospective study of 35 nephroblastoma diagnosed and treated in the central region of Tunisia within the last 8 years (1991-1999). We report and compare clinical features, therapeutic results and prognostic factors with those reported in the literature. The mean age was 3-years and 9 months, and the main clinical symptom was abdominal mass. Pre-operative chemotherapy was done in 32 cases and the objective response rate was 58%. Thirty-three patients had radical nephrectomy and only one had partial nephrectomy. Histologic analysis concluded to an anaplastic nephroblastoma in 2 cases. Using the classification of the international society of pediatric oncology, 11.4% of tumours were stage I, 48.6% stage II, 5.7% stage III, 11.4% stage IV and 2.9% stage V. The overall 5 years survival was 80%; tumour relapse was only independent prognosis factor in multivariate analysis (P < 0.01). Prognosis of nephroblastoma has been improved with chemotherapy and the pluridisciplinar treatment.
authors.affiliation: Service de médecine carcinologique, CHU Farhat-Hached, Sousse 4000, Tunisie.
authors.forename: L
authors.initials: L
authors.lastname: Amel
authors.forename: B F
authors.initials: BF
authors.lastname: Leila
authors.forename: K
authors.initials: K
authors.lastname: Lamia
authors.forename: G
authors.initials: G
authors.lastname: Olfa
authors.forename: Z
authors.initials: Z
authors.lastname: Abdelfattah
authors.forename: G
authors.initials: G
authors.lastname: Mondher
authors.forename: M
authors.initials: M
authors.lastname: Faouzi
authors.forename: K
authors.initials: K
authors.lastname: Chakib
authors.forename: N
authors.initials: N
authors.lastname: Abdelatif
authors.forename: G
authors.initials: G
authors.lastname: Amor
authors.forename: B A
authors.initials: BA
authors.lastname: Slim
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D008297:Male; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009392:Nephrectomy; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D014416:Tunisia; D009396:Wilms Tumor / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery
vernacular_title: Etude anatomoclinique et pronostique des néphroblastomes dans le centre tunisien.