title: Podocyte proliferation and differentiation in glomerular disease: role of cell-cycle regulatory proteins.
abstract: Injury to the podocyte underlies many forms of glomerular disease. In contrast to mesangial and endothelial cells, podocytes do not typically proliferate. Moreover, the lack of proliferation is thought to underlie the development of glomerulosclerosis. Studies have recently shown that the lack of podocyte proliferation is due to an increase in cyclin-dependent kinase inhibitors, which arrest the cell cycle. Current work is aimed at further delineating the mechanisms regulating podocyte proliferation.
authors.affiliation: Division of Nephrology, University of Washington Medical Center, Seattle, WA 98195, USA. stuartjs@u.washington.edu
authors.forename: Siân V
authors.initials: SV
authors.lastname: Griffin
authors.forename: Arndt T
authors.initials: AT
authors.lastname: Petermann
authors.forename: Raghu V
authors.initials: RV
authors.lastname: Durvasula
authors.forename: Stuart J
authors.initials: SJ
authors.lastname: Shankland
mesh_terms: D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D004847:Epithelial Cells / Q000502:physiology*; D005923:Glomerulosclerosis, Focal Segmental / Q000503:physiopathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000503:physiopathology*
chemical_list: D018797:Cell Cycle Proteins