No association between a putative functional promoter variant in the dopamine beta-hydroxylase gene and schizophrenia.
OBJECTIVE
Disturbances in catecholamine transmission have been implicated in schizophrenia. Dopamine beta-hydroxylase catalyses the conversion of dopamine to norepinephrine in noradrenergic cells. We attempted to investigate a putative functional promoter polymorphism in the dopamine beta-hydroxylase gene (DBH) for association with schizophrenia.


METHODS
Unrelated schizophrenic patients (n=155) and control subjects (n=436) were analysed with regard to the DBH -1021 C/T variant.


RESULTS
No significant allele or genotype differences were found.


CONCLUSIONS
The present results do not support a major involvement of the DBH gene in schizophrenia in the Swedish population investigated.
Jönsson
Erik G
EG
Department of Clinical Neuroscience, Psychiatry Section, HUBIN project, Karolinska Institute, SE-171 76 Stockholm, Sweden. erikj@ks.se
Abou Jamra
Rami
R
Schumacher
Johannes
J
Flyckt
Lena
L
Edman
Gunnar
G
Forslund
Kaj
K
Mattila-Evenden
Marja
M
Rylander
Gunnar
G
Asberg
Marie
M
Bjerkenstedt
Lars
L
Wiesel
Frits-Axel
FA
Propping
Peter
P
Cichon
Sven
S
Nöthen
Markus M
MM
Sedvall
Göran C
GC
D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012016:Reference Values; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics*; D013548:Sweden
D004299:Dopamine beta-Hydroxylase