Catecholamine and oxytocin cells respond to hypovolaemia as well as hypotension.
Medullary catecholamine and hypothalamic neurosecretory oxytocin cells are activated by hypotension, but previous studies have provided uncertain outcomes concerning their ability to respond to a purely hypovolaemic stimulus. In the present study, injections of PEG/water and pentolinium were used to elicit non-hypotensive, isosmotic hypovolaemia and isovolaemic, isosmotic hypotension, respectively, in conscious rats. Animals were sacrificed 2 h after treatment. Immunolabelling for Fos, tyrosine hydroxylase and oxytocin established that these two stimuli activate almost identical populations of catecholamine neurons in the ventrolateral and dorsomedial medulla, and very similar populations of oxytocin cells in the supraoptic and paraventricular nuclei of the hypothalamus.
Smith
Doug W
DW
School of Biomedical Sciences, University of Queensland, Brisbane, Queensland 4072, Australia. dwsmith@ucsd.edu
Day
Trevor A
TA
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000502:physiology; D002395:Catecholamines / Q000502:physiology*; D007022:Hypotension / Q000503:physiopathology*; D020896:Hypovolemia / Q000139:chemically induced / Q000503:physiopathology*; D008526:Medulla Oblongata / Q000166:cytology / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D010121:Oxytocin / Q000096:biosynthesis / Q000502:physiology*; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000378:metabolism; D010425:Pentolinium Tartrate / Q000494:pharmacology; D011092:Polyethylene Glycols; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D013495:Supraoptic Nucleus / Q000166:cytology / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D014667:Vasopressins / Q000378:metabolism
D000959:Antihypertensive Agents; D002395:Catecholamines; D016760:Proto-Oncogene Proteins c-fos; D014667:Vasopressins; D011092:Polyethylene Glycols; D010121:Oxytocin; D010425:Pentolinium Tartrate; D014446:Tyrosine 3-Monooxygenase