Natural autoantibodies as tools to predict the outcome of immune response?
Natural autoantibodies (NAbs), produced by B-1 B-cells, are directed against autoantigens and pathogens. NAbs can capture and present antigen to T helper cells thereby initiating adaptive immunities. It is proposed that screening for NAbs against pathogens will predict the strength of an antigen-induced immune response and could be used as a tool for vaccine development.
Kohler
H
H
Department of Microbiology and Immunology, University of Kentucky, Lexington, KY 40536, USA. hkohl00@pop.uky.edu
Bayry
J
J
Nicoletti
A
A
Kaveri
S V
SV
D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens