title: The reproductive system at the neuroendocrine-immune interface: focus on LHRH, estrogens and growth factors in LHRH neuron-glial interactions.
abstract: Bidirectional communication between the neuroendocrine and immune systems plays a pivotal role in health and disease. Signals generated by the hypothalamic-pituitary-gonadal (HPG) axis (i.e. luteinizing hormone-releasing hormone, LHRH, and sex steroids) are major players coordinating the development immune system function. Conversely, products generated by immune system activation exert powerful and longlasting effects on HPG axis activity. In the central nervous system (CNS), one chief neuroendocrine-immune (NEI) compartment is represented by the astroglial cell population and its mediators. Of special interest, the major supporting cells of the brain and the thymus, astrocytes and thymic epithelial cells, share a similar origin and a similar set of peptides, transmitters, hormones and cytokines functioning as paracrine/autocrine regulators. This may explain some fundamental analogies in LHRH regulation of both cell types during ontogeny and in adult life. Hence, the neuropeptide LHRH significantly modulates astrocyte and thymic cell development and function. Here we focus this work on LHRH neuron-glial signaling cascades which dictate major changes during LHRH neuronal differentiation and growth as well as in response to hormonal manipulations and pro-inflammatory challenges. The interplay between LHRH, growth factors, estrogens and pro-inflammatory mediators will be discussed, and the potential physiopathological implications of these findings summarized. The overall study highlights the plasticity of this intersystem cross-talk and emphasize neuron-glial interactions as a key regulatory level of neuroendocrine axes activity.
authors.affiliation: Department of Neuropharmacology, OASI Institute for Research and Care (IRCCS) on Mental Retardation and Brain Aging, Via Conte Ruggero 73, 94018 Troina (EN), Italy.
authors.forename: M C
authors.initials: MC
authors.lastname: Morale
authors.forename: F
authors.initials: F
authors.lastname: Gallo
authors.forename: C
authors.initials: C
authors.lastname: Tirolo
authors.forename: F
authors.initials: F
authors.lastname: L'Episcopo
authors.forename: F
authors.initials: F
authors.lastname: Gennuso
authors.forename: N
authors.initials: N
authors.lastname: Testa
authors.forename: S
authors.initials: S
authors.lastname: Caniglia
authors.forename: V
authors.initials: V
authors.lastname: Spina-Purrello
authors.forename: R
authors.initials: R
authors.lastname: Avola
authors.forename: G M
authors.initials: GM
authors.lastname: Scoto
authors.forename: B
authors.initials: B
authors.lastname: Marchetti
mesh_terms: D000818:Animals; D001253:Astrocytes; D002478:Cells, Cultured; D004967:Estrogens / Q000502:physiology*; D016222:Fibroblast Growth Factor 2 / Q000502:physiology; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology*; D007109:Immunity; D009457:Neuroglia; D009474:Neurons; D009490:Neurosecretory Systems; D012098:Reproduction
chemical_list: D004967:Estrogens; D006133:Growth Substances; D016222:Fibroblast Growth Factor 2; D007987:Gonadotropin-Releasing Hormone