Tomographic optical breast imaging guided by three-dimensional mammography.
We introduce a modified Tikhonov regularization method to include three-dimensional x-ray mammography as a prior in the diffuse optical tomography reconstruction. With simulations we show that the optical image reconstruction resolution and contrast are improved by implementing this x-ray-guided spatial constraint. We suggest an approach to find the optimal regularization parameters. The presented preliminary clinical result indicates the utility of the method.
Li
Ang
A
Department of Physics, Tufts University, Medford, Massachusetts 02155, USA. angli@nmr.mgh.harvard.edu
Miller
Eric L
EL
Kilmer
Misha E
ME
Brukilacchio
Thomas J
TJ
Chaves
Tina
T
Stott
Jonathan
J
Zhang
Quan
Q
Wu
Tao
T
Chorlton
MaryAnn
M
Moore
Richard H
RH
Kopans
Daniel B
DB
Boas
David A
DA
D001940:Breast; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008327:Mammography; D008962:Models, Theoretical; D055095:Optics and Photonics; D014054:Tomography