title: Voriconazole treatment of presumptive disseminated Aspergillus infection in a child with acute leukemia.
abstract: Invasive fungal infection continues to pose a significant threat to immunocompromised patients. The authors describe a pediatric patient receiving chemotherapy for acute undifferentiated leukemia who developed presumptive Aspergillus species infection disseminated to lung, liver, spleen, and bone. The authors report the successful treatment of this infection with the addition of voriconazole, a triazole antimycotic, to treatment with amphotericin and surgical debridement, in the setting of ongoing intensive chemotherapy.
authors.affiliation: Dalhousie University Medical School, Halifax, Nova Scotia, Canada.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Shouldice
authors.forename: Conrad
authors.initials: C
authors.lastname: Fernandez
authors.forename: Barbara
authors.initials: B
authors.lastname: McCully
authors.forename: Matthias
authors.initials: M
authors.lastname: Schmidt
authors.forename: Robert
authors.initials: R
authors.lastname: Fraser
authors.forename: Chris
authors.initials: C
authors.lastname: Cook
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D003131:Combined Modality Therapy; D003646:Debridement; D004359:Drug Therapy, Combination; D005260:Female; D006505:Hepatitis / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008172:Lung Diseases, Fungal / Q000188:drug therapy; D009894:Opportunistic Infections / Q000188:drug therapy; D010019:Osteomyelitis / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use*; D012074:Remission Induction; D012446:Sacroiliac Joint / Q000382:microbiology / Q000601:surgery; D013158:Splenic Diseases / Q000188:drug therapy / Q000382:microbiology; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D065819:Voriconazole