[Investigations on the stability of therapeutic drugs derived from imidazole. XII. Qualitative and quantitative stability evaluation of phentolamine hydrochloride solutions].
Hydrolysis of phentolamine hydrochloride in aqueous solutions, and at pH 1.0 and pH 8.0 was studied by means of thin-layer chromatography. A spectrophotometric method for quantitative assessment of phentolamine hydrochloride hydrolysis has been elaborated, and thermodynamic parameters of this reaction were determined.
Grabowska
I
I
Katedra i Zakład Chemii Farmaceutycznej Wydziału Farmaceutycznego Akademii Medycznej w Gdańsku, Al. K.Marksa 107, 80-416 Gdańsk.
Rajzer
D
D
Kraczkowska
A
A
Kremska
B
B
D002855:Chromatography, Thin Layer; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007093:Imidazoles / Q000737:chemistry*; D010646:Phentolamine / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D013053:Spectrophotometry / Q000379:methods; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
D007093:Imidazoles; D012996:Solutions; D014867:Water; C029899:imidazole; D010646:Phentolamine
Badania trwałości środków leczniczychpochodnych imidazoliny.XII. Jakościowa i ilościowa ocena trwałości roztworów chlorowodorku fentolaminy.