Absence of an inhibitory effect of omeprazole and nizatidine on phenytoin disposition, a marker of CYP2C activity.
The effects of omeprazole (40 mg orally per day) and nizatidine (300 mg orally per day) on the disposition of phenytoin (4.5 mg kg(-1) p.o. single dose) were studied in 18 healthy, young adult males. Total and unbound plasma concentrations of phenytoin were measured for 48 h after each dose of phenytoin. Neither treatment altered the disposition kinetics of phenytoin, the hydroxylation of which is mediated specifically by cytochromes P450 of the 2C subfamily.
Bachmann
K A
KA
The Center for Applied Pharmacology, The University of Toledo College of Pharmacy, Toledo, Ohio 43606, USA.
Sullivan
T J
TJ
Jauregui
L
L
Reese
J H
JH
Miller
K
K
Levine
L
L
D000328:Adult; D000704:Analysis of Variance; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000927:Anticonvulsants / Q000493:pharmacokinetics*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D016567:Nizatidine / Q000008:administration & dosage / Q000494:pharmacology*; D009853:Omeprazole / Q000008:administration & dosage / Q000494:pharmacology*; D010672:Phenytoin / Q000097:blood / Q000493:pharmacokinetics*
D000897:Anti-Ulcer Agents; D000927:Anticonvulsants; C400322:cytochrome P-450 CYP2C subfamily; D010672:Phenytoin; D003577:Cytochrome P-450 Enzyme System; D009853:Omeprazole; D016567:Nizatidine