The effects of growth hormone and sex steroid on lean body mass, fat mass, muscle strength, cardiovascular endurance and adverse events in healthy elderly women and men.
Decreases in growth hormone (GH) and insulin-like growth factor I occur with age, in addition to oestrogen deficiency in women and a reduction in the levels of testosterone in men. These age-related hormonal changes may contribute to reductions in lean body mass, muscle strength and cardiac endurance, which can be partially reversed in elderly people with GH treatment, and testosterone supplements and oestrogen/progestin hormone replacement therapy in men and women, respectively. These treatments are, however, thought to have potentially serious adverse effects. We conducted a study to evaluate the separate and interactive effects of GH and sex steroids on body composition, muscle strength and cardiac endurance as well as the rate of adverse events in healthy elderly people. The results of the study showed that although there were beneficial effects with GH and sex steroid treatment, a high percentage of adverse effects occurred after 26 weeks of treatment, demonstrating a need for more research on the safety of hormonal therapy in the elderly population.
Harman
S Mitchell
SM
National Institute on Aging, National Institutes of Health, Baltimore, MD, USA. Harman@kronosinstitute.org
Blackman
Marc R
MR
D000273:Adipose Tissue / Q000187:drug effects*; D000368:Aged; D001823:Body Composition / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects*; D002319:Cardiovascular System / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D012739:Gonadal Steroid Hormones / Q000009:adverse effects / Q000494:pharmacology*; D013006:Growth Hormone / Q000009:adverse effects / Q000494:pharmacology*; D020249:Hormone Replacement Therapy; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects*; D010146:Pain / Q000139:chemically induced; D010807:Physical Endurance / Q000187:drug effects*; D013739:Testosterone / Q000494:pharmacology
D012739:Gonadal Steroid Hormones; D013739:Testosterone; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone