Microchip-based high-throughput screening analysis of combinatorial libraries.
In recent years, there have been significant advances in biochemical assay miniturization and integration of microchip-based technologies with combinatorial library screening for high-throughput and large-scale applications. Small-molecule microarrays, protein arrays and cell-based arrays and conventional DNA arrays as well as microfluidic approaches in HTS are discussed in this review.
Khandurina
Julia
J
Torrey Mesa Research Institute, 3115 Merryfield Row, San Diego, CA 92121, USA.
Guttman
András
A
D000818:Animals; D020650:Combinatorial Chemistry Techniques; D023281:Genomics; D006801:Humans; D008904:Miniaturization; D020411:Oligonucleotide Array Sequence Analysis; D040081:Protein Array Analysis; D040901:Proteomics