title: Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource.
abstract: Schistosoma japonicum causes schistosomiasis in humans and livestock in the Asia-Pacific region. Knowledge of the genome of this parasite should improve understanding of schistosome-host interactions, biomedical aspects of schistosomiasis and invertebrate evolution. We assigned 43,707 expressed sequence tags (ESTs) derived from adult S. japonicum and their eggs to 13,131 gene clusters. Of these, 35% shared no similarity with known genes and 75% had not been reported previously in schistosomes. Notably, S. japonicum encoded mammalian-like receptors for insulin, progesterone, cytokines and neuropeptides, suggesting that host hormones, or endogenous parasite homologs, could orchestrate schistosome development and maturation and that schistosomes modulate anti-parasite immune responses through inhibitors, molecular mimicry and other evasion strategies.
authors.affiliation: Chinese National Human Genome Center at Shanghai, 351 Guo shou-Jing Road, Shanghai 201203, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Hu
authors.forename: Qing
authors.initials: Q
authors.lastname: Yan
authors.forename: Da-Kang
authors.initials: DK
authors.lastname: Shen
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Zhi-Dong
authors.initials: ZD
authors.lastname: Zhu
authors.forename: Huai-Dong
authors.initials: HD
authors.lastname: Song
authors.forename: Xiang-Ru
authors.initials: XR
authors.lastname: Xu
authors.forename: Zhao-Jun
authors.initials: ZJ
authors.lastname: Wang
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Rong
authors.forename: Ling-Chun
authors.initials: LC
authors.lastname: Zeng
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Ju-Jun
authors.initials: JJ
authors.lastname: Wang
authors.forename: Xue-Nian
authors.initials: XN
authors.lastname: Xu
authors.forename: Sheng-Yue
authors.initials: SY
authors.lastname: Wang
authors.forename: Gang
authors.initials: G
authors.lastname: Fu
authors.forename: Xiang-Lin
authors.initials: XL
authors.lastname: Zhang
authors.forename: Zhi-Qin
authors.initials: ZQ
authors.lastname: Wang
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Brindley
authors.forename: Donald P
authors.initials: DP
authors.lastname: McManus
authors.forename: Chun-Liang
authors.initials: CL
authors.lastname: Xue
authors.forename: Zheng
authors.initials: Z
authors.lastname: Feng
authors.forename: Zhu
authors.initials: Z
authors.lastname: Chen
authors.forename: Ze-Guang
authors.initials: ZG
authors.lastname: Han
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D018076:DNA, Complementary / Q000235:genetics; D018509:DNA, Helminth / Q000235:genetics*; D019143:Evolution, Molecular; D017238:Genes, Helminth; D006790:Host-Parasite Interactions; D006801:Humans; D008322:Mammals; D008969:Molecular Sequence Data; D010802:Phylogeny; D012549:Schistosoma japonicum / Q000145:classification / Q000235:genetics*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
chemical_list: D018076:DNA, Complementary; D018509:DNA, Helminth