[Renal cell carcinoma in adults less than 40 years of age: a particular cancer? Incidence, outcome and review of the literature].
OBJECTIVE
To study the incidence, clinical presentation, pathological prognostic factors and disease outcome of RCC in young adults less than 40-years-old.


METHODS
The notes of 400 patients treated by radical nephrectomy for RCC suspicion, between January 1984 and december 1999 were reviewed. Twenty-nine patients (7.25%) were under 40.


RESULTS
The most common histological cell type was clear cell carcinoma, found in 20 patients (69%). At a median follow-up of 80 months, 20 patients (69%) were disease free and 9 (31%) died of the disease. When comparing patients less than 40 years vs older than 40 years, we found significant differences in histology type (clear cell carcinoma 69% vs 91%; P = 0.0001), and tumor stage at presentation (pT2 = 34.5% vs 17.3%; P = 0.04) (pT3 = 20.7% vs. 42%; P = 0.03). Disease free survival was not significantly different between the 2 groups (69% vs 65.7%; Log rank test P = 0.4).


CONCLUSIONS
Although rare, RCC in young adults seems to follow a course similar to the disease seen in older patients. Stage at presentation was different between the 2 populations however survival was not affected by age.
Rodriguez
A
A
Service d'urologie, département d'urologie, hôpital Pontchaillou, CHU Rennes, rue Henri-Le-Guilloux, 35033 Rennes, France. armbkdd@yahoo.com
Tazi
H
H
Patard
J J
JJ
Lobel
B
B
D000328:Adult; D017668:Age of Onset; D002292:Carcinoma, Renal Cell / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015994:Incidence; D007680:Kidney Neoplasms / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome
Le cancer du rein de l'adulte de moins de 40 ans: un cancer particulier? Incidence, évolution et revue de la littérature.