title: No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans.
abstract: Several susceptibility loci for both of schizophrenia and bipolar disorder (BPD) have been found to overlap on several chromosomes including 8p21. Expression of dihydropyrimidinase-related protein 2 (DRP-2), which gene is located on 8p21, was found to be reduced in the brains of individuals with schizophrenia and BPD. Recently, we demonstrated a significant association between the DRP-2 gene and schizophrenia. Based on the rationale, we investigated the genetic association of the DRP-2 gene with BPD using a case-control study in the Japanese population. However, no significant associations were found between five polymorphisms of the DRP-2 gene (-975C>G, 352G>A, 426C>T, 1506T>C, and *2236T>C), and BPD, nor were associations detected between either of the polymorphisms and any subtype of BPD, bipolars I and II. The present study did not provide any evidence for a contribution of the DRP-2 gene to susceptibility to BPD.
authors.affiliation: Okayama University Graduate School of Medicine and Dentistry, Shikata-cho 2-5-1, Okayama 700-8558, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ujike
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Manabu
authors.initials: M
authors.lastname: Takaki
authors.forename: Ayumu
authors.initials: A
authors.lastname: Sakai
authors.forename: Akira
authors.initials: A
authors.lastname: Nomura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Katsu
authors.forename: Naohiko
authors.initials: N
authors.lastname: Uchida
authors.forename: Takaki
authors.initials: T
authors.lastname: Imamura
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Takashi
authors.initials: T
authors.lastname: Hamamura
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Kuroda
mesh_terms: D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000201:enzymology* / Q000235:genetics*; D016022:Case-Control Studies; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D007564:Japan; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics*; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; D011506:Proteins; C095114:collapsin response mediator protein-2