title: Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives.
abstract: New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at C2 showed strong cytotoxicity.
authors.affiliation: College of Pharmacy, Chungnam National University, Taejon 305-764, South Korea.
authors.forename: Young-Jae
authors.initials: YJ
authors.lastname: You
authors.forename: Yong
authors.initials: Y
authors.lastname: Kim
authors.forename: Nguyen-Hai
authors.initials: NH
authors.lastname: Nam
authors.forename: Byung-Zun
authors.initials: BZ
authors.lastname: Ahn
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity*; D045744:Cell Line, Tumor; D006801:Humans; D053978:Pentacyclic Triterpenes; D014315:Triterpenes / Q000138:chemical synthesis* / Q000633:toxicity*; D000094062:Betulinic Acid
chemical_list: D000970:Antineoplastic Agents; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D000094062:Betulinic Acid