[Plantar-palmar erythrodysesthesia. A new and relatively frequent side effect in antineoplastic treatment].
Palmar-plantar erythrodysesthesia (PPE, hand-foot syndrome) is a relatively frequent cutaneous toxicity related to antineoplastic treatment with e.g. fluorouracil, capecitabine, and liposomal doxorubicin. It usually presents as paresthesia and painful erythema of the palms and soles and may lead to ulceration of the skin. The symptoms are dose-dependent, and the condition may be dose-limiting. Two cases of chemotherapy-associated PPE are presented.
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Onkologisk Klinik, Finsencentret 5073, H:S Rigshospitalet, DK-2100 København ø.
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Seppo W
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D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000069287:Capecitabine; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000009:adverse effects; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects; D005533:Foot Dermatoses / Q000139:chemically induced* / Q000473:pathology; D006229:Hand Dermatoses / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013577:Syndrome
D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D003841:Deoxycytidine; D000069287:Capecitabine; D004317:Doxorubicin; D005472:Fluorouracil
Plantar-palmar erytrodysaestesi. En ny og relativt hyppigt forekommende bivirkning ved antineoplastisk behandling.