title: Effects of benzodiazepines on enzymes metabolizing drugs. IV. Effect of diazepam and oxazepam on hepatic microsomal drug metabolizing enzymes in rats exposed to high environmental temperature.
abstract: Administration of diazepam or oxazepam caused a different response of the rat hepatic microsomal cytochrome P-450 dependent monooxygenase system. Both drugs produced significant decrease in the activity of NADH: cytochrome c oxidoreductase in rats exposed to 21 degrees C, but not to 28 degrees C and 35 degrees C, and did not change the activity of aniline hydroxylase, aminopyrine N-demethylase and 4-nitroanisole O-demethylase and cytochrome b5 level at any tested temperatures. Oxazepam, but not diazepam, caused a decrease in cytochrome P-450 content in rats exposed to 21 degrees C only. The results indicate that the high ambient temperature modifies the effect of tested benzodiazepines on the activity of some microsomal enzymes.
authors.affiliation: Department of Drug Metabolism, School of Medicine, 1 Banacha Str., 02-097 Warsaw, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Pachecka
authors.forename: K
authors.initials: K
authors.lastname: Kobylińska
authors.forename: B
authors.initials: B
authors.lastname: Zagdańska
authors.forename: H
authors.initials: H
authors.lastname: Zasłona
authors.forename: W
authors.initials: W
authors.lastname: Bicz
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D003864:Depression, Chemical; D003975:Diazepam / Q000494:pharmacology*; D004777:Environment; D006358:Hot Temperature; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010076:Oxazepam / Q000494:pharmacology*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats
chemical_list: D014151:Anti-Anxiety Agents; D004364:Pharmaceutical Preparations; D010076:Oxazepam; D006899:Mixed Function Oxygenases; D003975:Diazepam