title: Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors.
abstract: The first fully automated multi-step polymer assisted solution phase (PASP) synthesis is described. An array of histone deacetylase (HDAc) inhibitors was prepared by an unattended 4-5 step sequence incorporating in-line 'catch and release' purification.
authors.affiliation: GlaxoSmithKline Cambridge Technology Centre, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
authors.forename: Emma
authors.initials: E
authors.lastname: Vickerstaffe
authors.forename: Brian H
authors.initials: BH
authors.lastname: Warrington
authors.forename: Mark
authors.initials: M
authors.lastname: Ladlow
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D001331:Automation; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D011108:Polymers; D010165:Palladium