title: Lispro insulin and metformin versus other combination in the diabetes mellitus type 2 management after secondary oral antidiabetic drug failure.
abstract: The purpose of the study was to find out differences between treatments of diabetes type 2 after secondary oral antidiabetic drug failure. Three different methods of treatment were compared: lispro insulin in combination with metformin, glimepiride and metformin combination or two daily doses of biphasic insulin 30/70 together with bed-time NPH insulin. The study included 87 patients with diabetes mellitus type 2 randomly distributed into 3 different treatment groups. Fasting and postprandial glucose were analyzed by enzymatic colorimetric method and HbA1c was measured by ion exchange chromatography. HbA1c significantly decreased in all three study groups. The decrease was mostly expressed among patients treated with lispro and metformin. When focused on postprandial glucose control, antihyperglycemic metformin and insulin lispro therapy has greater impact on the overall metabolic control (decrease in level of HbA1c) in comparison with the above mentioned more traditional approaches.
authors.affiliation: Department of Internal Medicine, University Hospital Split, Split, Croatia.
authors.forename: Slaven
authors.initials: S
authors.lastname: Kokić
authors.forename: Damir
authors.initials: D
authors.lastname: Buković
authors.forename: Maja
authors.initials: M
authors.lastname: Radman
authors.forename: Vesna
authors.initials: V
authors.lastname: Capkun
authors.forename: Nikica
authors.initials: N
authors.lastname: Gabrić
authors.forename: Vesna
authors.initials: V
authors.lastname: Lesko
authors.forename: Deni
authors.initials: D
authors.lastname: Karelović
authors.forename: Tajana
authors.initials: T
authors.lastname: Stancerić
mesh_terms: D000284:Administration, Oral; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007328:Insulin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D061268:Insulin Lispro; D008297:Male; D008687:Metformin / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D019518:Postprandial Period; D013453:Sulfonylurea Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D061268:Insulin Lispro; D013453:Sulfonylurea Compounds; C057619:glimepiride; D008687:Metformin