Effects of human pregnancy on fluid regulation responses to short-term exercise.
This study tested the hypothesis that human pregnancy alters fluid and electrolyte regulation responses to acute short-term exercise. Responses of 22 healthy pregnant women (PG; gestational age, 37.0 +/- 0.2 wk) and 17 nonpregnant controls (CG) were compared at rest and during cycling at 70 and 110% of the ventilatory threshold (VT). At rest, ANG II concentration was significantly (P < 0.05) higher in PG vs. CG, whereas plasma osmolality and concentrations of AVP, sodium, and potassium were significantly lower. Atrial natriuretic peptide concentration at rest was similar between groups. ANG II and AVP concentrations increased significantly from rest to 110% VT in CG only, whereas increases in atrial natriuretic peptide concentration were similar between groups. Increases in osmolality, and total protein and albumin concentrations from rest to both work rates were similar between the two groups. PG and CG exhibited similar shifts in fluid during acute short-term exercise, but the increases in ANG II and AVP were absent and attenuated, respectively, during pregnancy. This was attributed to the significantly augmented fluid volume state already present at rest in late gestation.
Heenan
Aaron P
AP
School of Physical and Health Education, Queen's University, Kingston, Ontario, Canada K7L 3N6.
Wolfe
Larry A
LA
Davies
Gregory A L
GA
McGrath
Michael J
MJ
D000328:Adult; D000418:Albumins / Q000378:metabolism; D015308:Anaerobic Threshold / Q000502:physiology; D000804:Angiotensin II / Q000494:pharmacology; D001127:Arginine Vasopressin / Q000494:pharmacology; D002245:Carbon Dioxide / Q000097:blood; D004573:Electrolytes / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood; D010953:Plasma Volume / Q000502:physiology; D011247:Pregnancy / Q000502:physiology*; D011374:Progesterone / Q000097:blood; D012084:Renin-Angiotensin System / Q000502:physiology; D015656:Respiratory Mechanics / Q000502:physiology; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014882:Water-Electrolyte Balance / Q000502:physiology*
D000418:Albumins; D004573:Electrolytes; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D001127:Arginine Vasopressin; D002245:Carbon Dioxide; D011374:Progesterone; D010100:Oxygen