Mutation and association analysis of the DAP-1 gene with schizophrenia.
Glutamate dysfunction has been hypothesized to be involved in the pathophysiology of schizophrenia. The human homolog of Drosophila discs large protein (hDLG) and post-synaptic density-95-associated protein-1 (DAP-1) is one of the major proteins that are involved in intracellular signal transduction via N-methyl-d-aspartate receptors. In the present study 33 Japanese patients with schizophrenia were screened for mutations in the DAP-1 gene. A single nucleotide polymorphism was identified in the DAP-1 gene (1618A/G). A case-control study using a larger sample of unrelated patients and controls did not reveal a significant association between this polymorphism and schizophrenia. The results do not provide evidence that the DAP-1 gene is involved in vulnerability to schizophrenia.
Aoyama
Shinsuke
S
Department of Environmental Health and Safety, Kobe University Graduate School of Medicine, Kobe, Japan.
Shirakawa
Osamu
O
Ono
Hisae
H
Hashimoto
Takeshi
T
Kajimoto
Yasuo
Y
Maeda
Kiyoshi
K
D016022:Case-Control Studies; D004247:DNA / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational; D000074407:SAP90-PSD95 Associated Proteins; D012559:Schizophrenia / Q000235:genetics*
C000614187:DLGAP1 protein, human; D009419:Nerve Tissue Proteins; D000074407:SAP90-PSD95 Associated Proteins; D004247:DNA