Fully automated multi-step solution phase synthesis using polymer supported reagents: preparation of histone deacetylase inhibitors.
The first fully automated multi-step polymer assisted solution phase (PASP) synthesis is described. An array of histone deacetylase (HDAc) inhibitors was prepared by an unattended 4-5 step sequence incorporating in-line 'catch and release' purification.
Vickerstaffe
Emma
E
GlaxoSmithKline Cambridge Technology Centre, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Warrington
Brian H
BH
Ladlow
Mark
M
Ley
Steven V
SV
D001331:Automation; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*
D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D011108:Polymers; D010165:Palladium