MLL-AF4 gene rearrangement in a child with Epstein-Barr virus-related posttransplant B-cell lymphoma.
Recipients of solid organ allografts are known to be at increased risk of developing Epstein-Barr virus-related posttransplant lymphoproliferative diseases. A 28-month-old boy who had received a heterotopic liver transplant presented with lymphadenopathy in the abdomen, multiple nodules in the liver, and bilateral renal infiltration 19 months after transplantation. He was diagnosed with a Burkitt-like lymphoma based on bone marrow examination and the finding that the blastic cells in bone marrow were EBER-1 positive. Cytogenetic analysis of the bone marrow cells showed an MLL-AF4 rearrangement. He was treated with a combined chemotherapy regimen. He has been in continuous complete remission for 15 months now.
Corapçioglu
Funda
F
Department of Pediatric Oncology, Institute of Oncology, Dokuz Eylul University, Izmir, Turkey. fundacorapcioglu@yahoo.com
Olgun
Nur
N
Sarialioglu
Faik
F
Uysal
Kamer Mutafoglu
KM
Oren
Hale
H
Sercan
Ogün
O
D001656:Biliary Atresia / Q000601:surgery; D002675:Child, Preschool; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics / Q000648:ultrastructure; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics / Q000648:ultrastructure; D018562:Disease Transmission, Infectious; D020031:Epstein-Barr Virus Infections / Q000635:transmission; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016031:Liver Transplantation / Q000009:adverse effects*; D016393:Lymphoma, B-Cell / Q000209:etiology / Q000235:genetics* / Q000821:virology; D008297:Male; D051788:Myeloid-Lymphoid Leukemia Protein; D015514:Oncogene Proteins, Fusion / Q000032:analysis / Q000235:genetics*; D014178:Translocation, Genetic; D014412:Tumor Virus Infections / Q000635:transmission
D007166:Immunosuppressive Agents; C113855:MLL-AF4 fusion protein, human; D015514:Oncogene Proteins, Fusion; D051788:Myeloid-Lymphoid Leukemia Protein