Cytomegalovirus infection in a patient with rheumatoid arthritis.
Background. - Pulmonary dysfunction in rheumatoid arthritis (RA) patients treated with low-dose methotrexate is usually caused by bacterial infection and less frequently by an immunoallergic reaction to the drug (acute hypersensitivity pneumonitis). Opportunistic infections are a rare cause. We report a case of cytomegalovirus pneumonia during bone marrow aplasia in a patient with RA taking methotrexate and cyclosporine.Conclusions. - Cytomegalovirus infection is a rarely reported cause of pulmonary dysfunction. This diagnosis should be considered in immunocompromised RA patients with no other satisfactory explanation for pulmonary dysfunction.
Belin
Véronique
V
Rheumatology Department, Lyon South Hospital Center, Lyon, France.
Tebib
Jacques
J
Vignon
Eric
E
D000741:Anemia, Aplastic / Q000139:chemically induced / Q000473:pathology; D000998:Antiviral Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology / Q000473:pathology; D016572:Cyclosporine / Q000009:adverse effects; D003587:Cytomegalovirus / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D005260:Female; D015774:Ganciclovir / Q000627:therapeutic use; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008727:Methotrexate / Q000009:adverse effects; D008875:Middle Aged; D011024:Pneumonia, Viral / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D012367:RNA, Viral / Q000032:analysis; D016896:Treatment Outcome
D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D012367:RNA, Viral; D016572:Cyclosporine; D015774:Ganciclovir; D008727:Methotrexate