Tyrosinase inhibitory prenylated flavonoids from Sophora flavescens.
For the purpose of the development of a skin-whitening agent, Sophora flavescens was evaluated for tyrosinase inhibitory activity and its active principles were identified following activity-guided isolation. The ethanol extract and dichloromethane fraction from S. flavescens showed significant inhibition of mushroom tyrosinase. From the dichloromethane fraction, three known prenylated flavonoids, sophoraflavanone G, kuraridin, and kurarinone, were isolated. Compared with kojic acid (IC(50)=20.5 microM), these compounds possessed more potent tyrosinase inhibitory activity. The IC(50) values were 6.6, 0.6, and 6.2 microM for sophoraflavanone G, kuraridin, and kurarinone, respectively.
Kim
Soo Jin
SJ
College of Pharmacy, Kangwon National University, Chunchon, Korea.
Son
Kun Ho
KH
Chang
Hyun Wook
HW
Kang
Sam Sik
SS
Kim
Hyun Pyo
HP
D000363:Agaricales / Q000201:enzymology; D004791:Enzyme Inhibitors; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D007723:Korea; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D018517:Plant Roots / Q000737:chemistry; D029909:Sophora / Q000737:chemistry*
D004791:Enzyme Inhibitors; D005419:Flavonoids; D014442:Monophenol Monooxygenase