Solid-phase synthesis of disulfide heterodimers of peptides.
[structure: see text] The synthesis of the orthogonal disulfide template 1 and its use to synthesize unsymmetrical intermolecular disulfide bond peptides on a solid support are described. Application of template 1 to synthesize bioconjugates of cell permeable moieties based on the disulfide bond is demonstrated.
Galande
Amit K
AK
Department of Chemistry and the Institute for the Molecular Diversity and Drug Design, University of Louisville, Louisville, Kentucky 40292, USA. amitgalande@yahoo.com
Spatola
Arno F
AF
D000595:Amino Acid Sequence; D003545:Cysteine / Q000031:analogs & derivatives*; D019281:Dimerization; D004220:Disulfides / Q000138:chemical synthesis*; D015195:Drug Design; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis*; D010456:Peptides, Cyclic / Q000138:chemical synthesis
D004220:Disulfides; D010455:Peptides; D010456:Peptides, Cyclic; D003545:Cysteine