Muraymycins, novel peptidoglycan biosynthesis inhibitors: synthesis and SAR of their analogues.
A series of Muraymycin analogues was synthesized. These analogues showed excellent antimicrobial activity against gram-positive organisms. These analogues also showed excellent inhibitory activity against the target peptidoglycan biosynthesis enzyme MraY, the cell membrane associated transglycosylase responsible for the formation of Lipid II.
Yamashita
Ayako
A
Chemical Sciences and Infectious Diseases, Wyeth Research, Pearl River, NY 10965, USA. yamashita@wyeth.com
Norton
Emily
E
Petersen
Peter J
PJ
Rasmussen
Beth A
BA
Singh
Guy
G
Yang
Youjin
Y
Mansour
Tarek S
TS
Ho
Douglas M
DM
D008826:Microbial Sensitivity Tests; D009711:Nucleotides; D010455:Peptides; D010457:Peptidoglycan / Q000031:analogs & derivatives* / Q000096:biosynthesis* / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014508:Urea
D009711:Nucleotides; D010455:Peptides; D010457:Peptidoglycan; C475707:muraymycin A3; D014508:Urea