A role for antibodies in tumor immunity.
Recent advances have demonstrated the clinical utility of specific monoclonal antibodies that recognize tumor-associated antigens on the surface of the tumor cell in the treatment of breast cancer and B cell lymphoma in humans. In addition to these studies, an experimental tumor model, where antibodies that recognize a viral-encoded tumor-specific antigen play a major role in tumor immunity, will be discussed. Together, these studies implicate antibodies as a means of providing tumor immunity against some cancers. The necessity for designing cancer vaccines that induce antibodies with specificity for antigens on the tumor cell will be discussed.
Kennedy
Ronald C
RC
Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, Texas 79430, USA. ronald.kennedy@ttuhsc.edu
Shearer
Michael H
MH
D000912:Antibodies, Neoplasm / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology; D002986:Clinical Trials as Topic; D006801:Humans; D009369:Neoplasms / Q000145:classification / Q000276:immunology*
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm