Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators.
Class II cytokine receptors were originally defined on the basis of sequence homologies in the extracellular domains of receptors for interferons (IFNs) and interleukin-10 (IL-10), and the ligands, known as class II cytokines, also have a common structure. More recently, a series of new receptors and cytokines that belong to this family have been discovered. The therapeutic potential of the 'old' members of this family, IFNs and IL-1, is recognized in the clinic, and the existence of structurally related molecules is raising expectations for additional clinical applications. In this review, I discuss both structural and biological data that are emerging about this family of receptors and ligands, to highlight the potential applications of modulating the activity of these cytokines.
Renauld
Jean-Christophe
JC
Ludwig Institute for Cancer Research, Brussels branch, and Experimental Medicine Unit, Université de Louvain, 74 Avenue Hippocrate, B1200 Brussels, Belgium. jean-christophe.renauld@bru.licr.org
D000595:Amino Acid Sequence; D000818:Animals; D016207:Cytokines / Q000737:chemistry / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008024:Ligands; D010802:Phylogeny; D017433:Protein Structure, Secondary; D018121:Receptors, Cytokine / Q000235:genetics / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines; D008024:Ligands; D018121:Receptors, Cytokine