title: Preparation of (5 alpha,13 alpha)-D-azasteroids as key precursors of a new family of potential GABAA receptor modulators.
abstract: Three groups of (5 alpha,13 alpha)-D-azasteroids, (5 alpha,13 alpha)-3-hydroxy-17a-aza-D-homoandrostans (12), (5 alpha,13 alpha)-3-hydroxy-17-aza-D-homoandrostans (15), and (5 alpha,13 alpha)-3-hydroxy-17-azaandrostans (17), were designed and synthesized as key precursors for the further preparation of a new family of potential GABAA receptor modulators from commercially available natural steroids (5 alpha)-3-hydroxyandrostane-17-ones (7).
authors.affiliation: Department of Chemistry, Nanjing University, Nanjing 210093, PR China.
authors.forename: Cunde
authors.initials: C
authors.lastname: Wang
authors.forename: Shaozhong
authors.initials: S
authors.lastname: Wang
authors.forename: Yingju
authors.initials: Y
authors.lastname: Xu
authors.forename: Yuefei
authors.initials: Y
authors.lastname: Hu
authors.forename: Hongwen
authors.initials: H
authors.lastname: Hu
mesh_terms: D000777:Anesthetics / Q000138:chemical synthesis; D001378:Azasteroids / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000777:Anesthetics; D001378:Azasteroids; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists