Survivin in brain tumors: an attractive target for immunotherapy.
Survivin, a member of the inhibitor of apoptosis proteins gene family, was recently shown to be expressed by tumors originating from different cell lineages. There are also cumulative evidences that spontaneous immune response against survivin derived epitopes may occur. Here, using RT-PCR, Western-blot analysis and immunohistochemistry, we show that survivin is widely expressed by gliomas, meningiomas and schwannomas, both in vitro and in vivo. These data indicate that survivin may serve as an attractive target for immunotherapies designed for brain tumors.
Katoh
Masahito
M
Laboratory of Tumor Immunology, Division of Oncology, University Hospital of Geneva, Geneva, Switzerland.
Wilmotte
Rick
R
Belkouch
Marie-Claude
MC
de Tribolet
Nicolas
N
Pizzolato
Gianpaolo
G
Dietrich
Pierre-Yves
PY
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015153:Blotting, Western; D001932:Brain Neoplasms / Q000378:metabolism* / Q000628:therapy; D045744:Cell Line, Tumor; D005260:Female; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007167:Immunotherapy; D051034:Inhibitor of Apoptosis Proteins; D008297:Male; D008579:Meningioma / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000276:immunology / Q000378:metabolism*; D008875:Middle Aged; D009363:Neoplasm Proteins; D009442:Neurilemmoma / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000077022:Survivin
C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin