title: Expression of CD38 in human promyelocytic leukemia HL-60 cell line during differentiation by niacin-related compounds.
abstract: It was found that three niacin-related compounds, isonicotinic acid, nicotinamide, and nicotinamide N-oxide, induced granulocytic differentiation in HL-60 cells. We investigated the expression of CD38, which catalyzes the synthesis of cyclic ADP-ribose, a Ca2+ mobilizer, during differentiation by niacin-related compounds. It was found that CD38 was induced by isonicotinic acid, whereas nicotinamide and nicotinamide N-oxide containing an amino group did not induce it. The difference in expression of CD38 may provide some useful information for the elucidation of the mechanisms of cell differentiation.
authors.affiliation: Laboratory of Molecular and Cellular Biology, Department of Life Science, Faculty of Bioresources, Mie University, Tsu, Mie 514-8507, Japan.
authors.forename: Keiko
authors.initials: K
authors.lastname: Iwata
authors.forename: Shin
authors.initials: S
authors.lastname: Ogata
authors.forename: Katsuzumi
authors.initials: K
authors.lastname: Okumura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Taguchi
mesh_terms: D036541:ADP-ribosyl Cyclase / Q000096:biosynthesis* / Q000378:metabolism; D051997:ADP-ribosyl Cyclase 1; D015703:Antigens, CD / Q000096:biosynthesis* / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D005434:Flow Cytometry; D015870:Gene Expression / Q000187:drug effects*; D018922:HL-60 Cells; D006801:Humans; D007539:Isonicotinic Acids / Q000494:pharmacology*; D008562:Membrane Glycoproteins; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D014212:Tretinoin / Q000378:metabolism / Q000494:pharmacology
chemical_list: D015703:Antigens, CD; D007539:Isonicotinic Acids; D008562:Membrane Glycoproteins; D009536:Niacinamide; D014212:Tretinoin; C037645:nicotinamide N-oxide; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1