The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria.
Dendritic cells are antigen presenting cells that are likely to be pivotal in the balance between tolerance and active immunity to commensal microorganisms that is fundamental to inflammatory conditions, including Crohn's disease and ulcerative colitis. Interactions between dendritic cells and microbial products are discussed and how they contribute to regulation of immune responses. The concept that interactions between dendritic cells and commensal organisms may be responsible for maintaining intestinal immune homeostasis is also explored.
Stagg
A J
AJ
Antigen Presentation Research Group, Faculty of Medicine, Imperial College London, UK. a.stagg@imperial.ac.uk
Hart
A L
AL
Knight
S C
SC
Kamm
M A
MA
D001424:Bacterial Infections / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D003713:Dendritic Cells / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000276:immunology*; D007422:Intestines / Q000276:immunology*; D008213:Lymphocyte Activation; D008221:Lymphoid Tissue / Q000276:immunology; D008855:Microscopy, Electron, Scanning; D013601:T-Lymphocytes / Q000276:immunology
D016207:Cytokines