Myocardial gene expression of inflammatory cytokines after heart transplantation in relation to the development of transplant coronary artery disease.
Long-term success of cardiac transplantation is mainly limited by the development of transplant coronary artery disease (CAD); it is generally accepted that it is immune mediated, involving cytokines and growth factors. We show that development of transplant CAD is associated with a particular cytokine profile in myocardial biopsies characterized by a late (i.e., 1 year) increase in tumor necrosis factor-alpha and interferon-gamma gene expression, which precede and potentially contribute to the development of allograft vasculopathy, further supporting a role for inflammation and the pathogenesis of transplant CAD in humans.
Ueland
Thor
T
Research Institute for Internal Medicine, National University Hospital, University of Oslo, N-0027 Oslo, Norway. thor.ueland@klinmed.uio.no
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D000328:Adult; D003324:Coronary Artery Disease / Q000209:etiology* / Q000235:genetics*; D016207:Cytokines / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D015870:Gene Expression / Q000235:genetics*; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma