Synthesis of a chitosan-dendrimer hybrid and its biodegradation.
Chitosan-dendrimer hybrids having various functional groups such as carboxyl, ester, and poly(ethylene glycol) groups were prepared successfully using dendrimer acetal by reductive N-alkylation. The synthetic procedure could be accomplished by one-step reaction without organic solvent. The degree of substitution of dendrimer was 0.13-0.18 evaluated by (1)H NMR. A perfectly or partially water-soluble chitosan-dendrimer hybrid could be obtained. By standard activated sludge, good biodegradation was observed in these hybrids.
Sashiwa
Hitoshi
H
Green Biotechnology Research Group, The Special Division for Human Life Technology, National Institute of Advanced Industrial Science and Technology, 1-8-31 Midorigaoka, Ikeda, Osaka 563-8577 Japan. h-sashiwa@aist.go.jp
Yajima
Hirufumi
H
Aiba
Sei-ichi
S
D000478:Alkylation; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000378:metabolism; D001673:Biodegradation, Environmental; D002686:Chitin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000378:metabolism; D048271:Chitosan; D009682:Magnetic Resonance Spectroscopy
D001672:Biocompatible Materials; D002686:Chitin; D048271:Chitosan