title: Rapid and efficient microwave-assisted amination of electron-rich aryl halides without a transition-metal catalyst.
abstract: [reaction: see text] A rapid and direct amination of aryl halides has been developed in good to high yields under microwave irradiation without a transition-metal catalyst. This reaction is a particularly powerful method for the coupling of electron-rich aryl halides with various amines. In some cases, the excellent regioselectivity could be observed, which facilitated the preparation of meta-substituted anilines from ortho- or para-substituted phenylhalides. In addition, a mechanism via the interesting benzyne intermediate has been proposed.
authors.affiliation: Department of Chemistry & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Chun-An
authors.initials: CA
authors.lastname: Fan
authors.forename: Fu-Min
authors.initials: FM
authors.lastname: Zhang
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Tu