Collapsing glomerulopathy coexisting with membranous glomerulonephritis in native kidney biopsies: a report of 3 HIV-negative patients.
Collapsing glomerulopathy (CG), a variant of idiopathic focal segmental glomerulosclerosis (FSGS), can occur in both human immunodeficiency virus (HIV)-positive and HIV-negative patients. Idiopathic membranous glomerulonephritis (MGN) has been reported to coexist with FSGS, but rarely with CG. We report 3 HIV-negative patients (2 men, 1 woman) who developed nephrotic syndrome secondary to MGN complicated by CG, with relatively rapid disease progression despite aggressive therapy.
Al-Shamari
Ali
A
Division of Nephrology, University of British Columbia, Vancouver, BC, Canada.
Yeung
Kit
K
Levin
Adeera
A
Taylor
Paul
P
Magil
Alexander
A
D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001706:Biopsy; D018450:Disease Progression; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000150:complications* / Q000628:therapy; D005923:Glomerulosclerosis, Focal Segmental / Q000150:complications* / Q000628:therapy; D018023:HIV Seronegativity; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000473:pathology*; D008297:Male; D009404:Nephrotic Syndrome / Q000209:etiology / Q000628:therapy; D017257:Ramipril / Q000627:therapeutic use; D017582:Renal Replacement Therapy; D012189:Retrospective Studies
D000806:Angiotensin-Converting Enzyme Inhibitors; D007166:Immunosuppressive Agents; D017257:Ramipril