title: The response of endocrine system to stress loads during space flight in human subject.
abstract: The responses of endocrine system to the exposure to stress-work load and hormonal changes during oral glucose tolerance tests were studied in the Slovak astronaut before (three weeks before flight), during (on the 4th and the 6th days of space flight), and after space flight (1-3 days and 15-17 days after space flight) on board of space station MIR. Blood samples during the tests were collected via cannula inserted into cubital vein, centrifuged in the special appliance Plasma-03, frozen in Kryogem-03, and at the end of the 8-day space flight transferred to Earth in special container for hormonal analysis. Preflight workload produced an increase of plasma norepinephrine and a moderate elevation of epinephrine levels. Plasma levels of insulin, growth hormone, prolactin and cortisol were not markedly changed immediately or 10 min after the end of work load. The higher increases of plasma growth hormone, prolactin and catecholamine levels were noted after workload during space flight as compared to preflight response. The higher plasma glucose and insulin levels were noted during the oral glucose tolerance test in space flight and also in the post flight period. Plasma epinephrine levels were slightly decreasing during glucose tolerance test; however, plasma norepinephrine levels were not changed. The similar patterns of catecholamine levels during glucose tolerance test were found when compared the preflight, in-flight and post flight values. These data demonstrate the changes of the dynamic responses of endocrine system to stress-work and metabolic loads during space flight in human subject.
authors.affiliation: Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia. ueenlaco@savba.sk
authors.forename: L
authors.initials: L
authors.lastname: Macho
authors.forename: J
authors.initials: J
authors.lastname: Koska
authors.forename: L
authors.initials: L
authors.lastname: Ksinantova
authors.forename: K
authors.initials: K
authors.lastname: Pacak
authors.forename: T
authors.initials: T
authors.lastname: Hoff
authors.forename: V B
authors.initials: VB
authors.lastname: Noskov
authors.forename: A I
authors.initials: AI
authors.lastname: Grigoriev
authors.forename: M
authors.initials: M
authors.lastname: Vigas
authors.forename: R
authors.initials: R
authors.lastname: Kvetnansky
mesh_terms: D000222:Adaptation, Physiological; D000337:Aerospace Medicine; D004703:Endocrine System / Q000378:metabolism* / Q000502:physiology; D004837:Epinephrine / Q000097:blood / Q000378:metabolism; D005080:Exercise Test; D005951:Glucose Tolerance Test; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism; D007328:Insulin / Q000097:blood / Q000378:metabolism; D009638:Norepinephrine / Q000097:blood / Q000378:metabolism; D005082:Physical Exertion / Q000502:physiology*; D011388:Prolactin / Q000097:blood / Q000378:metabolism; D013026:Space Flight; D013312:Stress, Physiological / Q000097:blood / Q000378:metabolism*; D014893:Weightlessness
chemical_list: D007328:Insulin; D011388:Prolactin; D013006:Growth Hormone; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine