title: Vascular effects of step I diet in hypercholesterolemic patients with coronary artery disease.
abstract: We administered a step I diet to 50 hypercholesterolemic patients with coronary artery disease during 12 weeks. Compared with baseline, the step I diet significantly changed lipoprotein levels, significantly improved the percent flow-mediated dilation response to hyperemia by 32 +/- 7% (p <0.001), increased plasma levels of nitrate by 45 +/- 12% (p = 0.013), and lowered plasma levels of malondialdehyde by 7 +/- 4% (p = 0.011). However, the step I diet did not significantly change serologic markers of inflammation, plaque stability, and thrombosis. Step I diet therapy improved endothelium-dependent vasodilation with an increase in plasma nitrogen oxide and a decrease in oxidant stress in hypercholesterolemic patients with coronary artery disease.
authors.affiliation: Vascular Medicine and Atherosclerosis Unit, Department of Cardiology, Gil Heart Center, Gachon Medical School, 1198 Kuwol-dong, Namdong-gu, Incheon, Korea. kwangk@ghil.com
authors.forename: Kwang Kon
authors.initials: KK
authors.lastname: Koh
authors.forename: Jeong Yeal
authors.initials: JY
authors.lastname: Ahn
authors.forename: Yu Mi
authors.initials: YM
authors.lastname: Choi
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Han
authors.forename: Dae Sung
authors.initials: DS
authors.lastname: Kim
authors.forename: Hyung Sik
authors.initials: HS
authors.lastname: Kim
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Ahn
authors.forename: In Suck
authors.initials: IS
authors.lastname: Choi
authors.forename: Eak Kyun
authors.initials: EK
authors.lastname: Shin
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology*; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology*; D018836:Inflammation Mediators / Q000097:blood; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009566:Nitrates / Q000097:blood; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology*; D014666:Vasomotor System / Q000187:drug effects / Q000503:physiopathology
chemical_list: D018836:Inflammation Mediators; D008074:Lipoproteins; D009566:Nitrates; D008315:Malondialdehyde