title: Evaluation of the corneal endothelium after hyperopic laser in situ keratomileusis.
abstract: OBJECTIVE
  To evaluate corneal endothelial changes after hyperopic laser in situ keratomileusis (LASIK) considering overestimation and underestimation of the cell count measurement.
  
  
  METHODS
  Department of Ophthalmology, Nara Medical University, Nara, Japan.
  
  
  METHODS
  The data were from the clinical trial of the Nidek EC-5000 excimer laser for hyperopic LASIK. The mean correction was 3.59 diopters (D) +/- 1.54 (SD) (range 2.0 to 6.0 D). Using noncontact specular microscopy, the corneal endothelial changes in 25 eyes of 15 patients who had hyperopic LASIK were measured. Follow-up ranged from 6 months (n = 25) to 1 year (n = 21). The overestimation and underestimation of the corneal endothelial cell count that would occur after +5.0 D hyperopic LASIK was hypothetically calculated.
  
  
  RESULTS
  The measured endothelial cell count per 1.0 mm(2) did not significantly decrease up to 1 year after hyperopic LASIK (preoperatively, 2508 +/- 395; at 1 year, 2814 +/- 349). The hypothetical calculation revealed that a +5.0 D hyperopic correction corresponded to a 0.1% underestimation of the corneal endothelial cell count.
  
  
  CONCLUSIONS
  Underestimation of the corneal endothelial cell count after hyperopic LASIK was negligible. Hyperopic LASIK with the Nidek EC-5000 excimer laser did not significantly decrease corneal endothelial cells up to 1 year after surgery.
authors.affiliation: Department of Ophthalmology, Nara Medical University, Nara, Japan. ynawa@naramed-u.ac.jp
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nawa
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Ueda
authors.forename: Kozo
authors.initials: K
authors.lastname: Masuda
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Ishibashi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Hara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uozato
mesh_terms: D000328:Adult; D000368:Aged; D002452:Cell Count; D048429:Cell Size; D002986:Clinical Trials as Topic; D004728:Endothelium, Corneal / Q000166:cytology* / Q000502:physiology; D005500:Follow-Up Studies; D006801:Humans; D006956:Hyperopia / Q000601:surgery*; D020731:Keratomileusis, Laser In Situ / Q000379:methods*; D008875:Middle Aged; D015337:Multicenter Studies as Topic