Living-donor kidney transplantation at Mayo Clinic--Rochester.
With the established benefits of living-donor kidney transplantation, our primary emphasis at Mayo Clinic, Rochester has been to develop protocols that allow living donation to occur even in the presence of relatively unusual or generally contraindicated situations. This approach has significantly increased the number of patients receiving kidney transplants in the past few years. Our protocols for extended criteria donors and recipients along with the exclusive use of laparoscopic donor nephrectomy have been major contributors to the increase in volume. ABO-incompatible and positive-crossmatch living-donor kidney transplant protocols also have increased the availability of transplants for our patients. Protocol biopsies have aided in the diagnosis of subclinical rejection, polyoma virus and chronic allograft nephropathy. Innovative immunosuppressive protocols such as calcineurin inhibitor-free immunosuppression have decreased rejection and improved both short and long-term renal allograft survival.
Stegall
Mark D
MD
Department of Surgery, Mayo Foundation and Clinic, Rochester, Minnesota, USA.
Larson
Timothy S
TS
Prieto
Mikel
M
Gloor
James
J
Textor
Stephen
S
Nyberg
Scott
S
Sterioff
Sylvester
S
Ishitani
Michael
M
Griffin
Matthew
M
Schwab
Thomas
T
Talor
Sandra
S
Cosio
Fernando
F
Kudva
Yogish
Y
Dicke-Henslin
Deborah
D
Kreps
Michelle
M
Fix
Lynette
L
Bauer
Cherise
C
Murphy
Mary
M
Kosberg
Kay
K
Tarara
Deborah
D
Velosa
Jorge
J
D000017:ABO Blood-Group System; D001787:Blood Group Incompatibility; D002102:Cadaver; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival / Q000502:physiology*; D006650:Histocompatibility Testing; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation / Q000276:immunology / Q000401:mortality / Q000706:statistics & numerical data*; D010535:Laparoscopy / Q000379:methods; D019520:Living Donors / Q000706:statistics & numerical data; D008910:Minnesota; D009392:Nephrectomy / Q000379:methods; D018579:Patient Selection; D014019:Tissue Donors; D020858:Tissue and Organ Harvesting / Q000379:methods; D016896:Treatment Outcome
D000017:ABO Blood-Group System