title: Off-Pump Coronary Artery Bypass (OPCAB) surgery reduces risk-stratified morbidity and mortality: a United Kingdom Multi-Center Comparative Analysis of Early Clinical Outcome.
abstract: OBJECTIVE
  Off-Pump Coronary Artery Bypass (OPCAB) surgery is gaining more popularity worldwide. The aim of this United Kingdom (UK) multi-center study was to assess the early clinical outcome of the OPCAB technique and perform a risk-stratified comparison with the conventional Coronary Artery Bypass Grafting (CABG) using the Cardio-Pulmonary Bypass (CPB) technique.
  
  
  METHODS
  Data were collected on 5,163 CPB patients from the database of the National Heart and Lung institute, Imperial College, University of London, and on 2,223 OPCAB patients from eight UK cardiac surgical centers, which run established OPCAB surgery programs. All patients had undergone primary isolated CABG for multi-vessel disease through a midline sternotomy approach, between January 1997 and April 2001. Postoperative morbidity and mortality were compared between the CPB and OPCAB patients after adjusting for case-mix. The mortality of the OPCAB patients was also compared, using risk stratification, to the mortality figures reported by the Society of Cardiothoracic Surgeons of Great Britain and Ireland (SCTS) based on 28,018 patients in the national database who were operated on between January 1996 and December 1999.
  
  
  RESULTS
  Morbidity and mortality were significantly lower in the OPCAB patients compared with the CPB patients and the UK national database of CABG patients, over the same period of time, after adjusting for case-mix.
  
  
  CONCLUSIONS
  This study demonstrates that risk stratified morbidity and mortality are significantly lower in OPCAB patients than CPB patients and patients in the UK national database.
authors.affiliation: National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Harefield Hospital, Middlesex UB9 6JH, United Kingdom.
authors.forename: Sharif
authors.initials: S
authors.lastname: Al-Ruzzeh
authors.forename: Gareth
authors.initials: G
authors.lastname: Ambler
authors.forename: George
authors.initials: G
authors.lastname: Asimakopoulos
authors.forename: Rumana Z
authors.initials: RZ
authors.lastname: Omar
authors.forename: Ragheb
authors.initials: R
authors.lastname: Hasan
authors.forename: Brian
authors.initials: B
authors.lastname: Fabri
authors.forename: Ahmed
authors.initials: A
authors.lastname: El-Gamel
authors.forename: Anthony
authors.initials: A
authors.lastname: DeSouza
authors.forename: Vipin
authors.initials: V
authors.lastname: Zamvar
authors.forename: Steven
authors.initials: S
authors.lastname: Griffin
authors.forename: Daniel
authors.initials: D
authors.lastname: Keenan
authors.forename: Uday
authors.initials: U
authors.lastname: Trivedi
authors.forename: Mark
authors.initials: M
authors.lastname: Pullan
authors.forename: Alex
authors.initials: A
authors.lastname: Cale
authors.forename: Michael
authors.initials: M
authors.lastname: Cowen
authors.forename: Kenneth
authors.initials: K
authors.lastname: Taylor
authors.forename: Mohamed
authors.initials: M
authors.lastname: Amrani
mesh_terms: D000328:Adult; D000368:Aged; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000379:methods / Q000401:mortality; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016896:Treatment Outcome; D006113:United Kingdom