Turnover of lymphocytes and conceptual paradigms in HIV infection.
Prevailing views concerning the pathogenic mechanisms of AIDS have shifted from models that focus primarily on direct HIV-mediated killing of CD4+ T cells to models that emphasize the pathogenic role of generalized immune system activation. The observation that increases in T cell turnover seen in HIV-infected individuals primarily reflect increased proliferation of effector-memory T cells supports the concept that chronic immune activation plays a prominent, if not predominant, role in the pathogenesis of AIDS.
Silvestri
Guido
G
Emory Vaccine Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA.
Feinberg
Mark B
MB
D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006706:Homeostasis; D006801:Humans; D007156:Immunologic Memory; D018655:Lymphocyte Count; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000502:physiology*