Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives.
New A-ring modified betulinic acid derivatives having small steric hindrance were prepared and tested for cytotoxic activity on 3 cancer cell lines: 10 compounds showed stronger cytotoxic activity than betulinic acid. Especially, the compounds bearing 1-ene-3-oxo with electron-withdrawing groups at C2 showed strong cytotoxicity.
You
Young-Jae
YJ
College of Pharmacy, Chungnam National University, Taejon 305-764, South Korea.
Kim
Yong
Y
Nam
Nguyen-Hai
NH
Ahn
Byung-Zun
BZ
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity*; D045744:Cell Line, Tumor; D006801:Humans; D053978:Pentacyclic Triterpenes; D014315:Triterpenes / Q000138:chemical synthesis* / Q000633:toxicity*; D000094062:Betulinic Acid
D000970:Antineoplastic Agents; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D000094062:Betulinic Acid