Intestinal transplantation: advances in immunosuppression and surgical techniques.
Campath-1H is being used as induction immunosuppression for intestinal/multivisceral transplantation. Patient and graft survival in this preliminary experience is similar to previous studies but there has been a significant decrease in the incidence and severity of acute rejections without increase of opportunistic infections. Collage of the abdominal wall (transplantation of a composite graft of the abdominal wall) can provide biologic coverage of the newly transplanted abdominal organs if necessary. Partial abdominal exenteration, ex vivo resection, and intestinal autotransplantation may be useful in removing otherwise unresectable lesions of the root of the mesentery.
Tzakis
A G
AG
Department of Surgery, Division of Transplantation, University of Miami School of Medicine, Miami, Florida 33136, USA.
Tryphonopoulos
P
P
Kato
T
T
Nishida
S
S
Levi
D M
DM
Nery
J R
JR
Madariaga
J
J
De Faria
W
W
Mittal
N
N
Thompson
J F
JF
Ruiz
P
P
D006084:Graft Rejection / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007422:Intestines / Q000637:transplantation*; D016031:Liver Transplantation / Q000276:immunology* / Q000379:methods* / Q000401:mortality; D012086:Reoperation; D016019:Survival Analysis; D014184:Transplantation, Homologous / Q000276:immunology* / Q000379:methods* / Q000401:mortality; D017211:Treatment Failure; D014781:Viscera / Q000637:transplantation*
D007166:Immunosuppressive Agents