title: Obesity: associations with acute mountain sickness.
abstract: BACKGROUND
  Although few retrospective studies of high altitude have reported that obesity might be associated with the development of acute mountain sickness (AMS), this association has not been studied prospectively.
  
  
  OBJECTIVE
  To determine whether obesity is associated with the development of AMS.
  
  
  METHODS
  Obese and nonobese men were compared at a simulated altitude of 3658 m (12 000 ft).
  
  
  METHODS
  24 hours in a hypobaric environmental chamber.
  
  
  METHODS
  9 obese and 10 nonobese men.
  
  
  METHODS
  Percentage body fat (by hydrostatic weighing), Lake Louise AMS score, and Sao2 level (by pulse oximetry) were measured.
  
  
  RESULTS
  Average AMS scores increased more rapidly with time spent at simulated high altitudes for obese men than for nonobese men (P < 0.001). The response of Sao2 with exposure differed between nonobese and obese men. After 24 hours in the altitude chamber, seven obese men (78%) and four nonobese men (40%) had AMS scores of 4 or more.
  
  
  CONCLUSIONS
  Obesity seems to be associated with the development of AMS, which may be partly related to greater nocturnal desaturation with altitude exposure.
authors.affiliation: Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Texas 75231, USA.
authors.forename: Ge
authors.initials: G
authors.lastname: Ri-Li
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Chase
authors.forename: Sarah
authors.initials: S
authors.lastname: Witkowski
authors.forename: Brenda L
authors.initials: BL
authors.lastname: Wyrick
authors.forename: Jeff A
authors.initials: JA
authors.lastname: Stone
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Levine
authors.forename: Tony G
authors.initials: TG
authors.lastname: Babb
mesh_terms: D000328:Adult; D000532:Altitude Sickness / Q000097:blood / Q000150:complications*; D000704:Analysis of Variance; D004198:Disease Susceptibility; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications*; D010100:Oxygen / Q000097:blood; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D010100:Oxygen