Cutaneous Waldenström's macroglobulinaemia.
We report a case of Waldenström's macroglobulinaemia that presented with infiltrated skin nodules and plaques but without systemic symptoms. Cutaneous manifestations such as purpura, oedema, urticaria and ulceration may be seen in Waldenström's macroglobulinaemia and are a consequence of hyperviscosity, cryoglobulinaemia and/or tissue deposition of immunoglobulins. Direct cutaneous infiltration by neoplastic lymphoid cells is less common, and very rare as the initial presentation of Waldenström's macroglobulinaemia.
Chan
I
I
St John's Institute of Dermatology, St Thomas' Hospital, London. ien.chan@kcl.ac.uk
Calonje
E
E
Whittaker
S J
SJ
D000368:Aged; D001706:Biopsy; D004893:Erythema Nodosum / Q000473:pathology; D005148:Facial Dermatoses / Q000473:pathology; D005260:Female; D005546:Forehead; D006801:Humans; D017445:Skin Diseases, Vascular / Q000473:pathology*; D008258:Waldenstrom Macroglobulinemia / Q000473:pathology*