title: Acute motor conduction block neuropathy Another Guillain-Barré syndrome variant.
abstract: OBJECTIVE
  To report two patients with an acute exclusively motor neuropathy with conduction blocks.
  
  
  METHODS
  Serial electrophysiologic studies were carried out.
  
  
  RESULTS
  Two patients developed symmetric proximal and distal weakness without sensory abnormalities after enteritis. Tendon reflexes were normal in one patient and brisk in the other. One patient had high titer immunoglobulin G to GD1a and GM1, and the other to GD1b, GD1a, and GM1 and a recent Campylobacter jejuni infection. Electrophysiology showed early partial motor conduction block in intermediate and distal nerve segments, normal sensory conductions even across the sites of conduction block, and normal somatosensory evoked potentials. Conduction blocks resolved in 2 to 5 weeks without excessive temporal dispersion of proximal motor responses.
  
  
  CONCLUSIONS
  Acute motor neuropathy with normal or brisk tendon reflexes, conduction block, and fast recovery appears to be a variant of Guillain-Barré syndrome. Conduction block may result from immune-mediated conduction failure at the nodes of Ranvier without demyelination.
authors.affiliation: Neuromuscular Diseases Unit, Institute of Aging, University G. d'Annunzio, Chieti, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Capasso
authors.forename: C M
authors.initials: CM
authors.lastname: Caporale
authors.forename: F
authors.initials: F
authors.lastname: Pomilio
authors.forename: P
authors.initials: P
authors.lastname: Gandolfi
authors.forename: A
authors.initials: A
authors.lastname: Lugaresi
authors.forename: A
authors.initials: A
authors.lastname: Uncini
mesh_terms: D000200:Action Potentials; D000208:Acute Disease; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D005260:Female; D020275:Guillain-Barre Syndrome / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D008297:Male; D016472:Motor Neuron Disease / Q000175:diagnosis* / Q000276:immunology; D009046:Motor Neurons / Q000502:physiology; D009431:Neural Conduction
chemical_list: D001323:Autoantibodies