Immune dysregulation in minimal change nephropathy.
Minimal change nephropathy (MCN) has been associated with a wide variety of abnormalities in the immune response of affected individuals. Many of these may be a consequence of the renal lesion, rather than a cause thereof. This article reviews some of these immunological phenomena and concentrates in particular on the imbalance between type 1 and type 2 cytokine responses, suggesting that there are plausible mechanisms whereby a type 2 cytokine bias could directly or indirectly cause MCN.
Mathieson
Peter W
PW
Academic Renal Unit, University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK. p.mathieson@bris.ac.uk
D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D009402:Nephrosis, Lipoid / Q000276:immunology*