[Postprandial hyperglycemia. Postprandial blood glucose fluctuations, cardiovascular disease and late diabetic complications].
Epidemiological studies have suggested that postprandial hyperglycaemia may be a unique risk factor for development of cardiovascular disease, although the predictive value has been minor or disappeared after compensation for other cardiovascular risk factors. Pathophysiological studies have demonstrated that acute changes in blood glucose may induce changes predisposing for development of microangiopathy in the retina, the kidneys and the nerves. Studies have also shown that postprandial hyperglycaemia may be a risk factor for the development of atherosclerosis. No randomised controlled trials have focused on specific treatment of postprandial hyperglycaemia. Therefore, the importance of postprandial hyperglycaemia for development of diabetic complications and atherosclerosis is unclear.
Madsbad
Sten
S
H:S Hvidovre Hospital, Medicinsk Center, Endokrinologisk Klinik, DK-2650 Hvidovre.
Brock
Birgitte
B
Schmitz
Ole
O
D001161:Arteriosclerosis / Q000209:etiology; D001786:Blood Glucose / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000209:etiology*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000209:etiology*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D019518:Postprandial Period; D012307:Risk Factors
D001786:Blood Glucose
Postprandial hyperglykaemi. Postprandiale blodglukosesvingninger og kardiovaskulaer sygdom samt sendiabetiske komplikationer.