title: The trials and tribulations of producing the first genetically engineered drug.
abstract: Fifty years ago, the determination of the structure of DNA sparked a genetic revolution. Here, I give a personal perspective of the challenges involved in the development of the first biological therapeutic resulting from this revolution: recombinant human insulin.
authors.affiliation: onniern@hypernet.com
authors.forename: Irving S
authors.initials: IS
authors.lastname: Johnson
mesh_terms: D000818:Animals; D015195:Drug Design; D049673:History, 20th Century; D006801:Humans; D007328:Insulin / Q000138:chemical synthesis / Q000235:genetics / Q000266:history*; D015202:Protein Engineering / Q000266:history* / Q000331:legislation & jurisprudence / Q000379:methods; D011994:Recombinant Proteins / Q000138:chemical synthesis / Q000266:history*; D014481:United States
chemical_list: D007328:Insulin; D011994:Recombinant Proteins