In vivo development of quinolone resistance in Salmonella enterica serotype typhimurium DT104.
Salmonella enterica serotype Typhimurium definitive phage type 104 was isolated several times from the same patient over a period of 2 years. The strain developed reduced sensitivity to fluoroquinolones, and a mutation in the gyrA gene that is associated with reduced sensitivity to quinolones was identified.
Kristiansen
Malthe A Melau
MA
Department of Clinical Microbiology, Research Unit for Clinical Microbiology, University of Southern Denmark, 6400 Sønderborg, Denmark. makblast@hotmail.com
Sandvang
Dorthe
D
Rasmussen
Thorkild Bremholm
TB
D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008875:Middle Aged; D012486:Salmonella typhimurium / Q000145:classification / Q000187:drug effects*; D012703:Serotyping
D000890:Anti-Infective Agents; D002939:Ciprofloxacin