CSF taurine level is influenced by plasma cholesterol and the CYP2D6 phenotype.
Eight healthy male volunteers, lumbar-punctured before and during simvastatin treatment, were phenotyped for CYP2D6 analysis of the debrisoquine metabolic ratio (the ratio between the urinary recovery of debrisoquine and its 4-hydroxy metabolite) after a single oral dose of debrisoquine. The mean cerebrospinal fluid concentrations of cholesterol and taurine did not differ before and during treatment. During (but not before) treatment taurine in the CSF correlated with the debrisoquine metabolic ratio (r=-0.93; P=0.0007) Our results might indicate an influence of CYP2D6 on the level of taurine in the CSF that was secondary to the change in plasma cholesterol.
Nordin
Conny
C
Department of Neuroscience and Locomotion, University Hospital, SE-581 85 Linköping, Sweden. conny.nordin@inr.liu.se
Dahl
Marja Liisa
ML
Eklundh
Thomas
T
Eriksson
Mats
M
Sjöberg
Stefan
S
D000328:Adult; D002784:Cholesterol / Q000097:blood*; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D006801:Humans; D008297:Male; D019821:Simvastatin / Q000494:pharmacology*; D013654:Taurine / Q000134:cerebrospinal fluid*
D013654:Taurine; D002784:Cholesterol; D019821:Simvastatin; D019389:Cytochrome P-450 CYP2D6