title: Concise synthesis, preparative resolution, absolute configuration determination, and applications of an atropisomeric biaryl catalyst for asymmetric acylation.
abstract: A new three-step synthesis and resolution of nucleophilic catalyst 1 suitable for large-scale preparation has been developed, and this catalyst has been shown to be effective for the kinetic resolution and asymmetric desymmetrization of a range of sec-alcohol substrates.
authors.affiliation: Department of Chemistry, University of Sheffield, Brook Hill, Sheffield S3 7HF, UK, Pfizer Global Research and Development-LaJolla, 10777 Science Center Drive, San Diego, California 92121, USA. a.c.spivey@imperial.ac.uk
authors.forename: Alan C
authors.initials: AC
authors.lastname: Spivey
authors.forename: Fujiang
authors.initials: F
authors.lastname: Zhu
authors.forename: Mark B
authors.initials: MB
authors.lastname: Mitchell
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Davey
authors.forename: Richard L
authors.initials: RL
authors.lastname: Jarvest