Pediatric intestinal transplantation.
OBJECTIVE
Analyze the results of a paediatric intestinal transplantation (IT) program in Spain.


METHODS
During an 5-year period, 18 children were included as candidates for IT. The causes for intestinal failure (IF) were short bowel syndrome (n=13), motility disorders (n=3), and congenital epithelial disorders (n=2). Nine children were admitted for a combined liver-small bowel transplant (LSBT), seven for an isolated intestinal transplantation (IIT) and two for a multivisceral transplantation (MVT). In three of the candidates for IIT the indication had to be changed to LSBT because of progression of the liver damage.


RESULTS
Eight candidates are on the waiting list: four for LSBT, two for IIT, and two for MVT. Four children died before transplantation. All were children under 1 year and candidates for LSBT. One child died during an attempted MVT. Five children underwent transplantation. Grafts were IIT in two and LSBT in three. Of these children, two are on a normal diet (respective follow-up times: 40 and 18 months), two died, both with functioning liver and intestinal grafts (hemorrage after liver biopsy and lymphoproliferative disease), and one developed an untreatable rejection that lead to loss of the intestinal graft; currently, she is on the waiting list for LSBT.


CONCLUSIONS
The morbidity and mortality of IT are high, but it is the only possible treatment for children in IF who cannot be adequately managed with parenteral nutrition. A severe problem is the the scarcity of suitable donors for the very low weight children who are candidates for LSBT.
López-Santamaría
M
M
Unit of Pediatric Liver Transplantation, Department of Pediatric Surgery, La Paz University Hospital, Madrid, Spain. mlopez.hulp@salud.madrid.org
Gámez
M
M
Murcia
M
M
Leal
N
N
Hernandez
F
F
de Vicente
E
E
Quijano
Y
Y
Prieto
G
G
Frauca
E
E
Sarriá
J
J
Molina
M
M
Polanco
I
I
Jara
P
P
Tovar
J
J
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007422:Intestines / Q000637:transplantation*; D012189:Retrospective Studies; D012778:Short Bowel Syndrome / Q000601:surgery*; D013030:Spain; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014850:Waiting Lists