title: [Hypertrophy and ventricular remodeling in systemic arterial hypertension: role of AT1 receptors].
abstract: Chronic systemic hypertension leads to structural and functional changes in the left ventricular myocardium through external and internal stimuli, altering the molecular structure of some peptides that influence hypertrophy and remodeling development. Genetic information evokes different responses in the cardiac myocyte, altering its morphology, metabolism, protein synthesis and the bioavailability of some hormonal receptors, promoting compensatory hypertrophy or apoptosis. In response to hemodynamic stress, the myocardial cell sensitizes and liberates angiotensin II (ATII) in an endogenous fashion and makes AT1 receptors to join this hormone tightly, perpetuating its deleterious effects. AT1 selective blockade prevent molecular and physiological damage lowering ATII bioavailability, down-regulating its production.
authors.affiliation: INCICH, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano No. 1, Col Sección XVI, Tlapan, CP 14080, México, D.F. México.
authors.forename: Paris
authors.initials: P
authors.lastname: Troyo Barriga
mesh_terms: D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D017379:Hypertrophy, Left Ventricular / Q000209:etiology* / Q000503:physiopathology; D020257:Ventricular Remodeling
vernacular_title: Hipertrofia y remodelación ventricular en la hipertensión arterial sistémica: papel de los receptores AT1.