Effect of simvastatin versus placebo on treadmill exercise time until the onset of intermittent claudication in older patients with peripheral arterial disease at six months and at one year after treatment.
Simvastatin significantly increased treadmill exercise time until onset of intermittent claudication from baseline by 54 seconds (a 24% increase, p <0.0001) at 6 months after treatment and by 95 seconds (a 42% increase, p <0.0001) at 1 year after treatment. At 6 months and 1 year after treatment with placebo, treadmill exercise time until onset of intermittent claudication was not significantly different from baseline exercise time.
Aronow
Wilbert S
WS
Department of Medicine, Cardiology Division, Westchester Medical Center/New York Medical College, Macy Pavilion Room 138, Valhalla, NY 10595, USA. WSAronow@aol.com
Nayak
Devraj
D
Woodworth
Steven
S
Ahn
Chul
C
D000368:Aged; D000369:Aged, 80 and over; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D007383:Intermittent Claudication / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D016491:Peripheral Vascular Diseases / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*; D012720:Severity of Illness Index; D019821:Simvastatin / Q000627:therapeutic use*; D013997:Time Factors
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin