[Efficacy of 4'-thio-5-ethyl-2'-deoxyuridine (TEDU) and its derivatives in experimental infection in mice caused by herpes simplex virus].
It was demonstrated that several 5'-phosphonates of 4'-thio-5-ethyl-2'-deoxyuridine possessed antiviral activity in vitro and in the murine model of herpes simplex virus type 1 infection. It was shown that the derivatives after intraabdominal administration penetrated effectively into the brain tissue. The agents provided statistically significant increase of the average life span, lower virus titre in the brain and lower lethality when compared to the control group of the animals. It is emphasized that the derivatives were less toxic than the original compound.
Andronova
V L
VL
D. I. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow.
Aleksandrova
L A
LA
Karpenko
I L
IL
Skoblov
Iu S
IuS
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D002522:Chlorocebus aethiops; D006561:Herpes Simplex / Q000188:drug therapy* / Q000821:virology; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D051379:Mice; D063065:Organophosphonates / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship; D013872:Thionucleosides / Q000737:chemistry / Q000502:physiology* / Q000633:toxicity; D023382:Toxicity Tests, Acute; D014709:Vero Cells
C479062:4'-thio-5-ethyl-2'-deoxyuridine; D000998:Antiviral Agents; D063065:Organophosphonates; D013872:Thionucleosides
Izuchenie éffektivnosti 4'-tio-5-étil-2'-deoksiuridina (TEDU) i ego proizvodnykh, vyzvannoĭ virusom gerpesa prostogo.