Supportive care in patients with advanced non-small-cell lung cancer.
The present study describes supportive care (SC) in patients with advanced non-small-cell lung cancer (NSCLC), evaluating whether it is affected by concomitant chemotherapy, patient's performance status (PS) and age. Data of patients enrolled in three randomised trials of first-line chemotherapy, conducted between 1996 and 2001, were pooled. The analysis was limited to the first three cycles of treatment. Supportive care data were available for 1185 out of 1312 (90%) enrolled patients. Gastrointestinal drugs (45.7%), corticosteroids (33.4%) and analgesics (23.8%) were the most frequently observed categories. The mean number of drugs per patient was 2.43; 538 patients (45.4%) assumed three or more supportive drugs. Vinorelbine does not produce substantial variations in the SC pattern, while cisplatin-based treatment requires an overall higher number of supportive drugs, with higher use of antiemetics (41 vs 27%) and antianaemics (10 vs 4%). Patients with worse PS are more exposed to corticosteroids (42 vs 30%). Elderly patients require drugs against concomitant diseases significantly more than adults (20 vs 7%) and are less frequently exposed to antiemetics (12 vs 27%). In conclusion, polypharmacotherapy is a relevant issue in patients with advanced NSCLC. Chemotherapy does not remarkably affect the pattern of SC, except for some drugs against side effects. Elderly patients assume more drugs for concomitant diseases and receive less antiemetics than adults.
Di Maio
M
M
National Cancer Institute: Clinical Trials Unit, Naples
Perrone
F
F
Gallo
C
C
Iaffaioli
R V
RV
Manzione
L
L
Piantedosi
F V
FV
Cigolari
S
S
Illiano
A
A
Barbera
S
S
Robbiati
S F
SF
Piazza
E
E
Ianniello
G P
GP
Frontini
L
L
Veltri
E
E
Castiglione
F
F
Rosetti
F
F
De Maio
E
E
Maione
P
P
Gridelli
C
C
Rossi
Antonio
A
Barletta
Emiddio
E
Barzelloni
Maria Luisa
ML
Signoriello
Giuseppe
G
Bilancia
Domenico
D
Dinota
Angela
A
Rosati
Gerardo
G
Germano
Domenico
D
Lamberti
Alfredo
A
Pontillo
Vittorio
V
Brancacio
Luigi
L
Crispino
Carlo
C
Esposito
Maria
M
Battiloro
Ciro
C
Tufano
Giovanni
G
Cioffi
Angela
A
Guardasole
Vincenzo
V
Angelini
Valentina
V
Guidetti
Giovanna
G
Barbera
Santi
S
Renda
Francesco
F
Romano
Francesco
F
Volpintesta
Antonio
A
Robbiati
Sergio Federico
SF
Sannicolò
Mirella
M
Filipazzi
Virginio
V
Esani
Gabriella
G
Gambaro
Anna
A
Ferrario
Sabrina
S
Tinessa
Vincenza
V
Caprio
Maria Grazia
MG
Zonato
Sabrina
S
Cabiddu
Mary
M
Raina
Alberto
A
Veltri
Enzo
E
D'Aprile
Modesto
M
Pistillucci
Giorgio
G
Porcile
Gianfranco
G
Ostellino
Oliviero
O
Vinante
Orazio
O
Azzarello
Giuseppe
G
Gebbia
Vittorio
V
Borsellino
Nicola
N
Testa
Antonio
A
Gasparini
Giampietro
G
Morabito
Alessandra
A
Gattuso
Domenico
D
Romito
Sante
S
Carrozza
Francesco
F
Fava
Sergio
S
Calcagno
Anna
A
Grimi
Emanuela
E
Bertetto
Oscar
O
Ciuffreda
Libero
L
Parello
Giuseppe
G
Maiorino
Luigi
L
Santoro
Antonio
A
Santoro
Massimiliano
M
Failla
Giuseppe
G
Aiello
Rosa Anna
RA
Bearz
Alessandra
A
Sorio
Roberto
R
Scalone
Simona
S
Clerici
Maurizia
M
Bollina
Roberto
R
Belloni
Paolo
P
Sacco
Cosimo
C
Sibau
Angela
A
Adamo
Vincenzo
V
Altavilla
Giuseppe
G
Scimone
Antonino
A
Spatafora
Mario
M
Bellia
Vincenzo
V
Hopps
Maria Raffealla
MR
Monfardini
Silvio
S
Favaretto
Adolfo
A
Stefani
Micaela
M
Corradini
Giuliana Mara
GM
Pavia
Gianfranco
G
Scagliotti
Giorgio
G
Novello
Silvia
S
Selvaggi
Giovanni
G
Tonato
Maurizio
M
Darwish
Samir
S
Michetti
Giovanni
G
Belometti
Maria Ori
MO
Labianca
Roberto
R
Quadri
Antonello
A
De Marinis
Filippo
F
Migliorino
Maria Rita
MR
Martelli
Olga
O
Colucci
Giuseppe
G
Galetta
Dominico
D
Giotta
Francesco
F
Isa
Luciano
L
Candido
Paola
P
Rossi
Nestore
N
Calandriello
Antonio
A
Ferraù
Francesco
F
Malaponte
Emilia
E
Barni
Sandro
S
Cazzaniga
Marina
M
Gebbia
Nicola
N
Valerio
Maria Rosaria
MR
Belli
Mario
M
Colantuoni
Giuseppe
G
Capuano
Matteo Antonio
MA
Angiolillo
Michele
M
Sollitto
Francesco
F
Ardizzoia
Antonio
A
Luporini
Gino
G
Locatelli
Maria Cristina
MC
Pari
Franca
F
Aitini
Enrico
E
Pedicini
Tonino
T
Febbraro
Antonio
A
Zollo
Cesira
C
Di Costanzo
Francesco
F
Bartolucci
Roberta
R
Gasperoni
Silvia
S
Gaion
Fernando
F
Palazzolo
Giovanni
G
Galligioni
Enzo
E
Caffo
Orazio
O
Cortesi
Enrico
E
D'Auria
Giuliana
G
Curcio
Carlo
C
Vasta
Matteo
M
Bumma
Cesare
C
Celano
Alfredo
A
Bretti
Sergio
S
Nettis
Giuseppe
G
Anselmo
Annamaria
A
Mattioli
Rodolfo
R
Nisticò
Cecilia
C
Aschelter
Annamaria
A
Foa
Paola
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000932:Antiemetics / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage; D003841:Deoxycytidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D015996:Survival Rate; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000077235:Vinorelbine; D000093542:Gemcitabine
D000932:Antiemetics; D003841:Deoxycytidine; D014747:Vinblastine; D002945:Cisplatin; D000077235:Vinorelbine; D000093542:Gemcitabine