Implicit learning of visuospatial sequences in schizophrenia.
The authors examined whether patients with schizophrenia learned sequential patterns in a probabilistic serial response time task in which pattern trials alternated with random ones. Patients showed faster and more accurate responses to pattern trials than to random trials, but controls showed greater sensitivity to patterns. The highest level of regularity learned in both groups was information about runs of 3 events. Pattern learning occurred largely outside of awareness, as participants could not describe patterns. Controls with higher memory spans learned the sequential pattern better than those with lower memory spans, suggesting that working memory influences implicit pattern learning. Pathology in motor sequencing systems and poor working memory may lead to deficits in learning sequence structure in schizophrenia.
Schwartz
Barbara L
BL
Mental Health Service Line, Washington, DC, Veterans Affairs Medical Center, 20422, USA. Barbara.Schwartz@med.va.gov
Howard
Darlene V
DV
Howard
James H
JH
Hovaguimian
Alexandra
A
Deutsch
Stephen I
SI
D000328:Adult; D001921:Brain / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual; D011597:Psychomotor Performance; D011930:Reaction Time; D012559:Schizophrenia / Q000503:physiopathology; D012565:Schizophrenic Psychology; D012691:Serial Learning