title: Endocannabinoid signalling in the blood of patients with schizophrenia.
abstract: OBJECTIVE
  To test the hypothesis that schizophrenia might be associated with alterations of the endogenous cannabinoid system in human blood.
  
  
  RESULTS
  Blood from 20 healthy volunteers and 12 patients with schizophrenia, 5 of which both before and after a successful antipsychotic treatment, was analysed for: 1) the amounts of the endocannabinoid anandamide; 2) the levels of cannabinoid CB1 and CB2 receptor mRNAs, and 3) the levels of the mRNA encoding the enzyme fatty acid amide hydrolase (FAAH), responsible for anandamide degradation. The amounts of anandamide were significantly higher in the blood of patients with acute schizophrenia than in healthy volunteers (7.79 +/- 0.50 vs. 2.58 +/- 0.28 pmol/ml). Clinical remission was accompanied by a significant decrease of the levels of anandamide (3.88 +/- 0.72 pmol/ml) and of the mRNA transcripts for CB2 receptors and FAAH.
  
  
  CONCLUSIONS
  These findings indicate that endocannabinoid signalling might be altered during the acute phase of schizophrenia not only in the central nervous system but also in the blood. These changes might be related to the several immunological alterations described in schizophrenia.
authors.affiliation: Endocannabinoid Research Group, Rochford Hospital, Rochford, UK. Nicola.DeMarchi@southessex-trst.nhs.uk
authors.forename: Nicola
authors.initials: N
authors.lastname: De Marchi
authors.forename: Luciano
authors.initials: L
authors.lastname: De Petrocellis
authors.forename: Pierangelo
authors.initials: P
authors.lastname: Orlando
authors.forename: Fabiana
authors.initials: F
authors.lastname: Daniele
authors.forename: Filomena
authors.initials: F
authors.lastname: Fezza
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Di Marzo