title: 2-piperidin-4-yl-benzimidazoles with broad spectrum antibacterial activities.
abstract: A series of 2-piperidin-4-yl-benzimidazoles were synthesized and evaluated for antibacterial activities. Certain compounds inhibit bacterial growth with low micromolar minimal inhibitory concentration (MIC). These benzimidazoles are effective against both Gram-positive and Gram-negative bacteria of clinical importance, particularly enterococci, and represent a new class of potential antibacterial agents.
authors.affiliation: Ibis Therapeutics, A Division of Isis Pharmaceuticals, Inc., 2292 Faraday Avenue, Carlsbad, CA 92008, USA. yhe@gnf.org
authors.forename: Yun
authors.initials: Y
authors.lastname: He
authors.forename: Baogen
authors.initials: B
authors.lastname: Wu
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Dale
authors.initials: D
authors.lastname: Robinson
authors.forename: Lisa
authors.initials: L
authors.lastname: Risen
authors.forename: Ray
authors.initials: R
authors.lastname: Ranken
authors.forename: Lawrence
authors.initials: L
authors.lastname: Blyn
authors.forename: Suzie
authors.initials: S
authors.lastname: Sheng
authors.forename: Eric E
authors.initials: EE
authors.lastname: Swayze
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001562:Benzimidazoles / Q000737:chemistry* / Q000494:pharmacology; D016983:Enterococcus / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests / Q000379:methods; D010880:Piperidines / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001562:Benzimidazoles; D010880:Piperidines