title: A 22-year French experience with solid tumors in children with Down syndrome.
abstract: Malignant solid tumors have rarely been reported in children with Down syndrome (DS) and are not well known. The authors collected from 1980 to 2001 all cases of solid tumors observed in DS patients aged from birth to 19 years within the network of the Société Française d'Oncologie Pédiatrique (SFOP). Only 21 cases were observed, with a peculiar distribution: a lack of intracranial tumors and embryonal neoplasms combined with an overrepresentation of lymphomas and germ cell tumors. The treatment of solid tumors in DS is difficult, due to physical and psychological impairments, different pharmacogenetic profile, and associated malformations.
authors.affiliation: Laboratoire d'Anatomie Pathologique, Centre Hospitalier, Tulle, France. daniel.satge@ch-tulle.fr
authors.forename: Daniel
authors.initials: D
authors.lastname: Satgé
authors.forename: Annie J
authors.initials: AJ
authors.lastname: Sasco
authors.forename: Agnès
authors.initials: A
authors.lastname: Chompret
authors.forename: Daniel
authors.initials: D
authors.lastname: Orbach
authors.forename: Françoise
authors.initials: F
authors.lastname: Méchinaud
authors.forename: Brigitte
authors.initials: B
authors.lastname: Lacour
authors.forename: Bernard
authors.initials: B
authors.lastname: Roullet
authors.forename: Hélène
authors.initials: H
authors.lastname: Martelli
authors.forename: Christophe
authors.initials: C
authors.lastname: Bergeron
authors.forename: Yves
authors.initials: Y
authors.lastname: Bertrand
authors.forename: Didier
authors.initials: D
authors.lastname: Lacombe
authors.forename: Yves
authors.initials: Y
authors.lastname: Perel
authors.forename: Pascal
authors.initials: P
authors.lastname: Monteil
authors.forename: Brigitte
authors.initials: B
authors.lastname: Nelken
authors.forename: Anne-Isabelle
authors.initials: AI
authors.lastname: Bertozzi
authors.forename: Martine
authors.initials: M
authors.lastname: Munzer
authors.forename: Justine
authors.initials: J
authors.lastname: Kanold
authors.forename: Fréderic
authors.initials: F
authors.lastname: Bernard
authors.forename: Michel J
authors.initials: MJ
authors.lastname: Vekemans
authors.forename: Danièle
authors.initials: D
authors.lastname: Sommelet
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004314:Down Syndrome / Q000150:complications* / Q000453:epidemiology; D005260:Female; D005602:France; D019337:Hematologic Neoplasms / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D009373:Neoplasms, Germ Cell and Embryonal / Q000209:etiology; D012189:Retrospective Studies