Vulnerability, destabilization and restitution in anxious depression.
OBJECTIVE
To summarize what is known about vulnerability and resilience to common mental disorders, and the psychosocial factors associated with speed of recovery.


METHODS
Recent genetic factors are summarized, and taken together with known facts about social factors encouraging or reducing likelihood of an episode.


RESULTS
Multiple genes are likely, controlling both vulnerability and resilience, with the manifestation in phenotype modified by environmental factors. Restitution must be thought of separately from vulnerability.


CONCLUSIONS
Instead of specific genes causing specific mental disorders, we need a more complex model.
Goldberg
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Institute of Psychiatry, King's College, London, UK.
D001007:Anxiety; D003866:Depressive Disorder / Q000235:genetics* / Q000523:psychology / Q000628:therapy; D004777:Environment; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006801:Humans; D007326:Institutionalization; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factors; D016896:Treatment Outcome