A tripeptidyl ensemble perspective of interactive control of growth hormone secretion.
Current investigational tools in molecular biology, biochemistry and integrative physiology have revealed an increasing array of signals that influence growth hormone (GH) secretion. The present perspective combines these factors under a simplified final-common pathway model of threefold joint control by GH-releasing hormone, GH-releasing peptide/ghrelin and somatostatin. This concept is highlighted from the viewpoint of sex steroid- and age-dependent modulation of the peptide trilogy listed above.
Veldhuis
Johannes D
JD
Mayo Medical and Graduate School of Medicine, Mayo Clinic, Rochester, MN 55905, USA. veldhuis.johannes@mayo.edu
D000375:Aging / Q000502:physiology; D000818:Animals; D001066:Appetite / Q000187:drug effects; D025461:Feedback, Physiological; D054439:Ghrelin; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology / Q000502:physiology*; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D036361:Peptide Hormones / Q000502:physiology*; D013004:Somatostatin / Q000502:physiology*
D054439:Ghrelin; D036361:Peptide Hormones; D019382:Human Growth Hormone; D013004:Somatostatin; D013007:Growth Hormone-Releasing Hormone