title: Association study between late-onset Alzheimer's disease and the transferrin gene polymorphisms in Chinese.
abstract: To investigate the possible involvement of the transferrin (TF) gene polymorphism in the manifestation of Alzheimer's disease (AD), we analyzed the TF and apolipoprotein E (APOE) genotypes of 67 sporadic late-onset AD patients and 131 normal elderly controls in the Chinese population. Our data showed that the TF C1 homozygosity carriers had an increased risk of AD in subjects > or =75 years of age, showing that homozygosity for the TF C1 allele was associated with an approximately three-fold increased risk (OR=3.57, 95% CI, 1.24-10.27, P=0.014). No synergic effects were found between the APOE epsilon 4 allele and TF gene polymorphisms.
authors.affiliation: Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Ze
authors.initials: Z
authors.lastname: Yang
authors.forename: Chuanfang
authors.initials: C
authors.lastname: Zhang
authors.forename: Zeping
authors.initials: Z
authors.lastname: Lu
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Shi
authors.forename: Weidong
authors.initials: W
authors.lastname: Zheng
authors.forename: Chunling
authors.initials: C
authors.lastname: Wan
authors.forename: Duanyang
authors.initials: D
authors.lastname: Zhang
authors.forename: Chenguang
authors.initials: C
authors.lastname: Zheng
authors.forename: Shu
authors.initials: S
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Jin
authors.forename: Li
authors.initials: L
authors.lastname: Wang
mesh_terms: D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D001923:Brain Chemistry / Q000235:genetics*; D002681:China / Q000208:ethnology; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D014168:Transferrin / Q000235:genetics*
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D014168:Transferrin