DSA: a new internal standard for NMR studies in aqueous solution.
[structure: see text] The widely used internal standard for NMR studies in aqueous solution DSS (sodium 4,4-dimethyl-4-silapentane-1-sulfonate) can interact with cationic peptides, diminishing its value for such studies. This paper introduces DSA (4,4-dimethyl-4-silapentane-1-ammonium trifluoroacetate) as a new internal standard that does not suffer from this problem.
Nowick
James S
JS
Department of Chemistry, University of California, Irvine, Irvine, California 92697-2025, USA.
Khakshoor
Omid
O
Hashemzadeh
Mehrnoosh
M
Brower
Justin O
JO
D024322:Amino Acids, Aromatic / Q000737:chemistry; D024361:Amino Acids, Basic / Q000737:chemistry; D005463:Fluoroacetates; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D017646:Organosilicon Compounds / Q000138:chemical synthesis*; D010455:Peptides / Q000032:analysis / Q000737:chemistry; D012015:Reference Standards; D015203:Reproducibility of Results; D012996:Solutions / Q000737:chemistry; D014269:Trifluoroacetic Acid / Q000138:chemical synthesis*; D014867:Water / Q000737:chemistry
C481198:4,4-dimethyl-4-silapentane-1-ammonium trifluoroacetate; D024322:Amino Acids, Aromatic; D024361:Amino Acids, Basic; D005463:Fluoroacetates; D017646:Organosilicon Compounds; D010455:Peptides; D012996:Solutions; D014867:Water; D014269:Trifluoroacetic Acid