[Sunscreens. Protection against skin cancers and photoaging].
Experimental animal studies have unambiguously demonstrated that topical sunscreens can prevent squamous cell carcinoma and photoaging (damage of collagen and elastic fibers of the skin). Although data from clinical studies and surrogate markers also indicate such photoprotective effects in man, there is a lack of controlled, prospective clinical trials to provide definite evidence in man. Because of inadequate data, no definite conclusions can be drawn about the cancer-preventive activity of topical use of sunscreens against basal cell carcinoma and malignant melanoma.
Wolf
P
P
Abteilung für Photodermatologie, Universitätsklinik für Dermatologie und Venerologie, Graz, Austria. peter.wolf@uni-graz.at
D000287:Administration, Topical; D000328:Adult; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000209:etiology / Q000517:prevention & control*; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000517:prevention & control*; D004195:Disease Models, Animal; D006801:Humans; D008545:Melanoma / Q000209:etiology / Q000517:prevention & control*; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000209:etiology / Q000517:prevention & control*; D013473:Sunscreening Agents / Q000008:administration & dosage*; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014810:Vitamin E / Q000627:therapeutic use
D000975:Antioxidants; D013473:Sunscreening Agents; D014810:Vitamin E; D001205:Ascorbic Acid
Lichtschutzmittel. Wirkung gegen Hautkrebs und Lichtalterung.