A new iridoid glycoside with nerve growth factor-potentiating activity, gelsemiol 6'-trans-caffeoyl-1-glucoside, from Verbena littoralis.
A new iridoid glycoside, gelsemiol 6'-trans-caffeoyl-1-glucoside (1), was isolated from Verbena littoralis, together with four known phenylethanoid glycosides, acteoside (2), 2'-acetylacteoside (3), jionoside (4), and isoverbascoside (5). Their structures were elucidated by spectral data. Compound 1 showed weak enhancement of nerve growth factor (NGF)-mediated neurite outgrowth from PC12D cells.
Li
Yushan
Y
Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Ishibashi
Masami
M
Satake
Masayuki
M
Oshima
Yasukatsu
Y
Ohizumi
Yasushi
Y
D002109:Caffeic Acids / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D004357:Drug Synergism; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D020932:Nerve Growth Factor / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000648:ultrastructure; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D032412:Verbena / Q000737:chemistry*
D002109:Caffeic Acids; D005960:Glucosides; C483340:gelsemiol 6'-trans-caffeoyl-1-glucoside; D020932:Nerve Growth Factor