Synthesis of heterocyclic and carbocyclic fluoro-olefins by ring-closing metathesis.
[reaction: see text] Ring-closing metathesis (RCM) of vinyl fluoride-containing dienes in the presence of ruthenium alkylidene carbene complex 11 proceeded efficiently to give six- and seven-membered cyclic vinyl fluorides. The RCM reaction was used to prepare amine- and sulfamide-linked cyclo-olefins, as well as carbocyclic systems, from a simple commercial fluoro-olefin.
Salim
Sofia S
SS
Department of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, U.K.
Bellingham
Richard K
RK
Satcharoen
Vachiraporn
V
Brown
Richard C D
RC