Synaptogenesis and heritable aspects of executive attention.
In humans, changes in brain structure and function can be measured non-invasively during postnatal development. In animals, advanced optical imaging measures can track the formation of synapses during learning and behavior. With the recent progress in these technologies, it is appropriate to begin to assess how the physiological processes of synapse, circuit, and neural network formation relate to the process of cognitive development. Of particular interest is the development of executive function, which develops more gradually in humans. One approach that has shown promise is molecular genetics. The completion of the human genome project and the human genome diversity project make it straightforward to ask whether variation in a particular gene correlates with variation in behavior, brain structure, brain activity, or all of the above. Strategies that unify the wealth of biochemical knowledge pertaining to synapse formation with the functional measures of brain structure and activity may lead to new insights in developmental cognitive psychology.
Fossella
John A
JA
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, USA. jaf2014@med.cornell.edu
Sommer
Tobias
T
Fan
Jin
J
Pfaff
Don
D
Posner
Michael I
MI
D000483:Alleles; D001288:Attention / Q000502:physiology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics; D003072:Cognition Disorders / Q000235:genetics*; D004252:DNA Mutational Analysis; D017931:DNA Primers / Q000235:genetics; D005600:Fragile X Syndrome / Q000235:genetics; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics* / Q000503:physiopathology*; D008565:Membrane Proteins / Q000235:genetics; D008967:Molecular Biology / Q000379:methods; D009419:Nerve Tissue Proteins / Q000235:genetics; D017354:Point Mutation / Q000235:genetics; D016133:Polymerase Chain Reaction; D020710:RGS Proteins / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000235:genetics; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics; D013569:Synapses / Q000502:physiology*; D050825:Synaptosomal-Associated Protein 25
D017931:DNA Primers; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D020710:RGS Proteins; D017448:Receptors, Dopamine D2; D016194:Receptors, N-Methyl-D-Aspartate; C494208:SNAP25 protein, human; D050825:Synaptosomal-Associated Protein 25; C098799:RGS4 protein