title: Organ system failure scoring system can predict hospital mortality in critically ill cirrhotic patients.
abstract: OBJECTIVE
  This study was conducted to assess and compare the accuracy of Child-Pugh classification and organ system failure (OSF) scores, obtained on the first day of ICU admission, in predicting the hospital mortality in critically ill cirrhotic patients.
  
  
  BACKGROUND
  Cirrhotic patients admitted to the medical intensive care unit (ICU) are associated with high mortality rates. The prognosis of critically ill cirrhotic patients is determined by the extent of hepatic and extrahepatic organ dysfunction.
  
  
  METHODS
  A total of 111 patients diagnosed with liver cirrhosis were admitted to medical ICU from July 2001 to June 2002. Information considered necessary to compute the Child-Pugh and OSF scores on the first day of ICU admission was prospectively collected.
  
  
  RESULTS
  The overall hospital mortality rate was 64.9%. Liver disease was most commonly attributed to hepatitis B viral infection. The OSF scores demonstrate a good fit using the Hosmer and Lemeshow goodness-of-fit test. Meanwhile, by using the areas under receiver operating characteristic (AUROC) curve, the OSF scores demonstrated an excellent discriminative power (AUROC 0.901), whereas the performance of Child-Pugh scores is clearly poorer (AUROC 0.748).
  
  
  CONCLUSIONS
  This investigation confirms that the prognosis for cirrhotic patients admitted to ICU is grave. The OSF score is a simple, reproducible, and easily applied tool with excellent prognostic abilities that can provide objective information for patients' families and physicians and supplement the clinical judgment of prognosis.
authors.affiliation: Division of Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan.
authors.forename: Ming-Hung
authors.initials: MH
authors.lastname: Tsai
authors.forename: Yung-Chang
authors.initials: YC
authors.lastname: Chen
authors.forename: Yu-Pin
authors.initials: YP
authors.lastname: Ho
authors.forename: Ji-Tseng
authors.initials: JT
authors.lastname: Fang
authors.forename: Jau-Min
authors.initials: JM
authors.lastname: Lien
authors.forename: Cheng-Tang
authors.initials: CT
authors.lastname: Chiu
authors.forename: Nai-Jen
authors.initials: NJ
authors.lastname: Liu
authors.forename: Pang-Chi
authors.initials: PC
authors.lastname: Chen
mesh_terms: D000368:Aged; D016638:Critical Illness / Q000145:classification / Q000401:mortality; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D008103:Liver Cirrhosis / Q000145:classification* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000175:diagnosis / Q000401:mortality*; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D012720:Severity of Illness Index