[Role of ORL1 receptors in the regulation of cardiac resistance to arrhythmogenic effects ].
It has been found that intravenous administration of nociceptin (0.4 mg/kg) prevents development of aconitine-induced arrhythmias but has no effect on the incidence of occlusion, reperfusion, CaCl2-induced arrhythmias, and exacerbates epinephrine-evoked dysrhythmias. Pretreatment with hexamethonium, atropine, guanethidine and naloxone did not abolish the arrhythmic effect of nociceptin. Intracerebroventricular infusion of orphanin FQ was shown to increase cardiac tolerance of arrhythmogenic influence of aconitine, but this effect is completely abolished by hexamethonium administration. It has been suggested that stimulation of both central and peripheral ORL1 receptors increases cardiac resistance against arrhythmogenic effect of aconitine via different mechanisms.
Maslov
L N
LN
Institute of Cardiology of the Russian Acad. Med. Sci., Siberian Branch, Tomsk State Pedagogical University, Tomsk, Russia.
Krylatov
A V
AV
Lishmanov
Iu B
IuB
Berger
H
H
Galo
G
G
Ma
L
L
Beyermann
M
M
Solenkova
N V
NV
Stakheev
D L
DL
D000157:Aconitine / Q000494:pharmacology; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D004195:Disease Models, Animal; D004562:Electrocardiography; D004837:Epinephrine / Q000494:pharmacology; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications; D015428:Myocardial Reperfusion Injury / Q000150:complications; D009206:Myocardium / Q000378:metabolism; D009292:Narcotic Antagonists; D018847:Opioid Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000819:agonists / Q000502:physiology*; D000094942:Nociceptin Receptor; D000097629:Nociceptin
D000157:Aconitine; D004837:Epinephrine; D009292:Narcotic Antagonists; D018847:Opioid Peptides; D011957:Receptors, Opioid; D000094942:Nociceptin Receptor; D000097629:Nociceptin; C000722285:Oprl1 protein, rat
O znachenii ORL1-retseptorov v reguliatsii ustoĭchivosti serdtsa k aritmogennym vozdeĭstviiam.