[The latest development of the research on Chinese medicine by molecular vibrational spectroscopy].
The latest development of the molecular vibrational spectroscopy (Fourier Transform Raman Spectroscopy and Fourier Transform Infraed Spectroscopy) and the latest application of the non-destructive identification, quantitative analysis, thermal-stability monitoring and Chinese medicine optimizing were described in this paper. Some Chinese crude herbs can be directly and quickly identified by Fourier Transform Raman spectroscopy (FT - Raman) and Diffused Reflection Fourier Transform Infrared Spectroscopy (DR-FTIR). The content of Chinese herbs, medicine and medicament can be quantified without destruction by Diffused Reflection Fourier Transform and Near Infrared Spectroscopy (DR-NIR-FTIR).  The mechanism of interaction between the Chinese medicine and some cells or bacteria can be in situ monitored by FT-Raman and HATR-FTIR. Best medicine could be selected and medicament could be optimized according to the injury degree of the cell or bacteria.  The decomposing and degenerating process of medicines can also be timely monitored by FT-Raman and the temperature controlled FTIR.  These are the latest use of molecular spectroscopy in Chinese medicine.  The fast indentification, quantitative analysis monitoring, thermal stability predicting and the optimizing of Chinese herbs, medicine and medicament can be guided by the above mentioned methods.  It is proved that these methods are nondestructive to samples, fast accurate, and easy to use.
Sun
S
S
Department of Chemistry, Tsinghua University, 100084 Beijing.
Zhou
Q
Q
Yu
J
J
Hu
X
X
D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D013059:Spectrum Analysis, Raman / Q000379:methods*; D014732:Vibration
D004365:Drugs, Chinese Herbal