[Determination of ultra-trace rare-earth elements in human plasma by inductively coupled plasma mass spectrometry].
Inductively coupled plasma mass spectrometry (ICP-MS), highly sensitive inorgnic analytic technique, fits to determine ultra-trace rare-earth elements in human plasma. Under the optimized conditions detection limits for 15 rare-earth elements are in the range of 0.7 (for Eu)-5.4 (for Gd) ng.L-1. Indium as an internal standard element is used to compensate for matrix suppression effect and sensitivity drift. Three kinds of preparation methods, diluted with 1% HNO3, digested with HNO3-H2O2 and with HNO3-HClO4, are checked and compared, and the former is the simplest way to be measured. The samples diluted with 1% HNO3, stored in 4 degrees C, are very steady for 16 days. With the method, 11 healthy plasma samples in Changchun area of China are analysed.
Chen
H
H
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, National Electrochemistry and the Analysis Center of Spectroscopy Research, 130022 Changchun.
Cao
S
S
Zeng
X
X
Meng
L
L
Zao
D
D
Ni
J
J
D005063:Europium / Q000097:blood; D005682:Gadolinium / Q000097:blood; D007811:Lanthanum / Q000097:blood; D013058:Mass Spectrometry / Q000379:methods*; D008674:Metals, Rare Earth / Q000097:blood*; D013054:Spectrophotometry, Atomic / Q000379:methods
D008674:Metals, Rare Earth; D005063:Europium; D007811:Lanthanum; D005682:Gadolinium