title: Effects of phototherapy in neonates on circadian sleep-wake and saliva cortisol level rhythms.
abstract: The influence of phototherapy treatment during the neonatal period on sleep-wake rhythm, and its long-term effects on biological rhythms, was evaluated in preterm and full-term infants. Forty-three infants treated with phototherapy during the neonatal period and 47 untreated infants were examined for entrainment of sleep-wake rhythms between 16 and 52 weeks and for sleep-wake and saliva cortisol rhythms at 2.5 years of age. The age of sleep-wake rhythm entrainment was not significantly different between the 2 groups. No correlations between duration of exposure to phototherapy and corrected age of entrainment of sleep-wake rhythm were observed. At follow-up, no significant differences in sleep-wake and saliva cortisol rhythms were observed between the 2 groups, indicating that circadian variations were similar to those in adults.
authors.affiliation: Department of Maternal and Child Health, Hamamatsu University School of Medicine, Hamamatsu City, Shizuoka Prefecture, Japan. mshimada@hama-med.ac.jp
authors.forename: Mieko
authors.initials: M
authors.lastname: Shimada
authors.forename: Masaya
authors.initials: M
authors.lastname: Segawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Higurashi
authors.forename: Rumiko
authors.initials: R
authors.lastname: Kimura
authors.forename: Kikuko
authors.initials: K
authors.lastname: Oku
authors.forename: Sadao
authors.initials: S
authors.lastname: Yamanami
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Akamatsu
mesh_terms: D016022:Case-Control Studies; D002940:Circadian Rhythm / Q000502:physiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D007231:Infant, Newborn / Q000502:physiology; D007234:Infant, Premature / Q000502:physiology; D008297:Male; D010789:Phototherapy / Q000379:methods; D012463:Saliva / Q000378:metabolism*; D012890:Sleep / Q000502:physiology*; D013997:Time Factors; D016896:Treatment Outcome; D014851:Wakefulness / Q000502:physiology*
chemical_list: D006854:Hydrocortisone