Treadmill exercise suppresses ischemia-induced increment in apoptosis and cell proliferation in hippocampal dentate gyrus of gerbils.
Cerebral ischemia resulting from transient or permanent occlusion of cerebral arteries leads to neuronal cell death and eventually causes neurological impairments. In the present study, the effects of treadmill exercise on apoptosis and cell proliferation in the hippocampal dentate gyrus following transient global ischemia in gerbils were investigated using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay and immunohistochemistry for caspase-3 and 5-bromo-2'-deoxyuridine (BrdU). It was shown that apoptotic cell death and cell proliferation in the hippocampal dentate gyrus were significantly increased following transient global ischemia in gerbils and that treadmill exercise suppressed the ischemia-induced increase in apoptosis and cell proliferation in the dentate gyrus. The present results suggest that treadmill exercise may protect cells from apoptotic death and aid in recovery from the central nervous system sequelae following stroke.
Lee
Myoung-Hwa
MH
Research Institute of Sports Science, Korea University, #1 5-Ka Anam-dong, Sungbuk-ku, Seoul 136-701 South Korea.
Kim
Hong
H
Kim
Sung-Soo
SS
Lee
Taeck-Hyun
TH
Lim
Baek-Vin
BV
Chang
Hyun-Kyung
HK
Jang
Mi-Hyeon
MH
Shin
Min-Chul
MC
Shin
Mal-Soon
MS
Kim
Chang-Ju
CJ
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D018891:Dentate Gyrus / Q000473:pathology*; D004195:Disease Models, Animal; D005849:Gerbillinae; D020287:In Situ Nick-End Labeling; D002546:Ischemic Attack, Transient / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D010805:Physical Conditioning, Animal; D005082:Physical Exertion