title: Nocistatin potentiates electroacupuncture antinociceptive effects and reverses chronic tolerance to electroacupuncture in mice.
abstract: Nocistatin (NST) and nociception/orphanin FQ (OFQ) are peptides derived from the same precursor that play opposing roles in pain modulation. OFQ antagonizes morphine analgesia and electroacupuncture (EA)-induced antinociceptive effect. The present study investigates whether NST potentiates EA-induced antinociceptive effect and reverses chronic tolerance to EA in mice. Injection of NST (0.5, 5.0 and 50.0 ng) intracerebroventricularly had no effect on basal thermal latency, but produced a dose-dependent potentiation of EA-induced antinociceptive effect in mice with the maximum response at 5.0 ng. NST (5.0 ng) partly reversed chronic tolerance to EA. These results suggest that NST in the brain might play roles in EA-induced antinociceptive effect and the development of chronic tolerance to EA in mice.
authors.affiliation: Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Huang
authors.forename: Hua
authors.initials: H
authors.lastname: Long
authors.forename: Yu-Shun
authors.initials: YS
authors.lastname: Shi
authors.forename: Ji-Sheng
authors.initials: JS
authors.lastname: Han
authors.forename: You
authors.initials: Y
authors.lastname: Wan
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D015671:Electroacupuncture / Q000379:methods*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018847:Opioid Peptides / Q000494:pharmacology*; D010147:Pain Measurement / Q000379:methods*
chemical_list: D000700:Analgesics; D018847:Opioid Peptides; C111148:nocistatin