[Surfacant sensitizing kinetic spectrophotometric determination of trace platinum].
A new kinetic spectrophotometric method for the determination of trace amount of platinum sensitizing by surfacant of emolsifier OP was proposed. It is based on the inhibition effect of platinum (IV) on the oxidizing decoloration of acid fuchsin by potassium bromate in 0.1 mol.L-1 sulphuric acid medium. The linear range for the determination of platinum is 0-2.2 micrograms.L-1. The detection limit is 0.06 microgram.L-1. Several parameter of the kinetic reaction were determined. The method is sensitive, selective and simple. It has been applied to the determination of trace platinum in chemotherapeutic drug cisplatin and serum from patients with satisfactory results.
Li
J
J
Department of Applied Chemistry, Guilin Institue of Technology, 541004 Guilin.
Wang
X
X
D000970:Antineoplastic Agents / Q000493:pharmacokinetics; D002945:Cisplatin / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D007700:Kinetics; D009369:Neoplasms / Q000097:blood* / Q000188:drug therapy; D010984:Platinum / Q000097:blood*; D013053:Spectrophotometry / Q000379:methods*; D013501:Surface-Active Agents
D000970:Antineoplastic Agents; D013501:Surface-Active Agents; D010984:Platinum; D002945:Cisplatin