Synthesis of S6-(2,4-dinitrophenyl)-6-thioguanosine phosphoramidite and its incorporation into oligoribonucleotides.
The preparation of N(2)-phenoxylacetyl-S(6)-(2,4-dinitrophenyl)-6-thioguanosine phosphoramidite and its subsequent incorporation into oligoribonucleotides is described. The identity of the oligonucleotides was confirmed by UV spectrophotometry and nucleoside composition analysis.
Zheng
Qinguo
Q
School of Life & Health Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK. q.zheng@aston.ac.uk
Wang
Yang
Y
Lattmann
Eric
E
D004136:Dinitrobenzenes / Q000032:analysis / Q000138:chemical synthesis*; D006151:Guanosine / Q000031:analogs & derivatives* / Q000032:analysis / Q000138:chemical synthesis*; D009843:Oligoribonucleotides / Q000032:analysis / Q000138:chemical synthesis*; D009943:Organophosphorus Compounds / Q000032:analysis / Q000138:chemical synthesis*; D013056:Spectrophotometry, Ultraviolet; D013872:Thionucleosides / Q000032:analysis / Q000138:chemical synthesis*; D013873:Thionucleotides / Q000032:analysis / Q000138:chemical synthesis*
D004136:Dinitrobenzenes; D009843:Oligoribonucleotides; D009943:Organophosphorus Compounds; D013872:Thionucleosides; D013873:Thionucleotides; C434331:phosphoramidite; D006151:Guanosine; C005783:6-thioguanosine