title: Concerning the wound-healing properties of Sphagnum holocellulose: the Maillard reaction in pharmacology.
abstract: Sphagnum wound dressings can be 3-4 times as absorbent as cotton equivalents, but they also react chemically with proteins of all kinds. This reactivity gives them the potential of immobilizing whole bacterial cells as well as the enzymes, exotoxins, and lysins secreted by the most invasive pathogens. Once immobilized, enzymes and (by inference) exotoxins and lysins are rapidly inactivated by a Maillard reaction. The complex pectin in Sphagnum is structurally similar to known, immunostimulatory pectins from other plants, including some that are traditionally used for wound healing.
authors.affiliation: Institute of Biotechnology, Norwegian University of Science and Technology, NO-7491 Trondheim, Norway.
authors.forename: Terence J
authors.initials: TJ
authors.lastname: Painter
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion; D002470:Cell Survival / Q000187:drug effects; D018914:Cells, Immobilized; D002482:Cellulose / Q000627:therapeutic use* / Q000633:toxicity; D004800:Enzymes, Immobilized; D007962:Leukocytes / Q000187:drug effects; D015416:Maillard Reaction; D009779:Occlusive Dressings; D028321:Plant Preparations / Q000627:therapeutic use* / Q000633:toxicity; D012867:Skin / Q000187:drug effects / Q000293:injuries; D044003:Sphagnopsida / Q000737:chemistry*; D013552:Swine; D014945:Wound Healing
chemical_list: D004800:Enzymes, Immobilized; D028321:Plant Preparations; D002482:Cellulose