title: Selective monoacylation of symmetrical diamines via prior complexation with boron.
abstract: [reaction: see text] Pretreatment of a symmetrical primary or secondary diamine with 9-BBN prior to the addition of an acyl chloride significantly suppressed undesired diacylation, and the product of monoacylation predominated. The reactive preference is interpreted as the result of a selective deactivation of one nitrogen atom of the diamine by 9-BBN.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492, USA.
authors.forename: Zhongxing
authors.initials: Z
authors.lastname: Zhang
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Yin
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Meanwell
authors.forename: John F
authors.initials: JF
authors.lastname: Kadow
authors.forename: Tao
authors.initials: T
authors.lastname: Wang