Hepatic failure with flutamide.
A 41-year-old woman, who was on flutamide for hair loss for 3 months, presented with deep jaundice. She developed hepatic encephalopathy but gradually recovered after discontinuing flutamide. Flutamide can cause fatal toxic liver injury and hence should be used with close monitoring of liver profile.
Kackar
R R
RR
Department Of Gastroenterology, Jaslok Hospital and Research Center, 15 Dr G Deshmukh Marg, Mumbai 400 026.
Desai
H G
HG
D000328:Adult; D000726:Androgen Antagonists / Q000009:adverse effects* / Q000633:toxicity*; D005260:Female; D005485:Flutamide / Q000009:adverse effects* / Q000633:toxicity*; D006201:Hair Diseases / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007565:Jaundice / Q000139:chemically induced; D017093:Liver Failure / Q000139:chemically induced*
D000726:Androgen Antagonists; D005485:Flutamide