title: No association of germline alteration of MSR1 with prostate cancer risk.
abstract: The macrophage scavenger receptor 1 gene (MSR1) was recently identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer. To confirm these findings, we screened MSR1 for germline mutations among individuals with familial prostate cancer and tested gene variants for associations in both sporadic and familial prostate cancer. Our results do not support MSR1 as a risk factor for prostate cancer.
authors.affiliation: Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, 920 Hilton Building, Mayo Clinic and Foundation, Rochester, Minnesota, USA.
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Shannon K
authors.initials: SK
authors.lastname: McDonnell
authors.forename: Julie M
authors.initials: JM
authors.lastname: Cunningham
authors.forename: Scott
authors.initials: S
authors.lastname: Hebbring
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Jacobsen
authors.forename: James R
authors.initials: JR
authors.lastname: Cerhan
authors.forename: Susan L
authors.initials: SL
authors.lastname: Slager
authors.forename: Michael L
authors.initials: ML
authors.lastname: Blute
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Schaid
authors.forename: Stephen N
authors.initials: SN
authors.lastname: Thibodeau
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014644:Genetic Variation; D018095:Germ-Line Mutation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*; D051116:Receptors, Scavenger; D012016:Reference Values; D012307:Risk Factors; D051117:Scavenger Receptors, Class A
chemical_list: C495139:MSR1 protein, human; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D051117:Scavenger Receptors, Class A; D017430:Prostate-Specific Antigen