title: Multifocal papillomavirus epithelial hyperplasia: successful treatment with CO2 laser therapy combined with interferon alpha-2b.
abstract: Human papilloma virus (HPV) infections of the oral mucosa presents with various clinical and histopathologic features in relation with the causative HPV type and chronicity and the extent of the infection.1 The entity is known by several names based on histopathologic variations such as focal epithelial hyperplasia, oral florid papillomatosis, verrucous hyperplasia, oral florid verrucosis, and Ackerman's tumor. In recent years, the term multifocal papillomavirus epithelial hyperplasia (MPVEH) has been proposed to define the variant that usually occurs in childhood and is characterized by diffuse confluent papillomatous lesions in the oral mucosa.1 Despite the lesions' benign appearance, early diagnosis and therapy of MPVEH is essential because of its high capacity for progression and its tendency for malign degeneration.
authors.affiliation: Department of Dermatology, Ankara University Medical Faculty, Ankara, Turkey.
authors.forename: Aynur
authors.initials: A
authors.lastname: Akyol
authors.forename: Rana
authors.initials: R
authors.lastname: Anadolu
authors.forename: Yücel
authors.initials: Y
authors.lastname: Anadolu
authors.forename: Pelin
authors.initials: P
authors.lastname: Ekmekci
authors.forename: Erbak
authors.initials: E
authors.lastname: Gürgey
authors.forename: Nisa
authors.initials: N
authors.lastname: Akay
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D053685:Laser Therapy; D008297:Male; D009059:Mouth Diseases / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*; D011994:Recombinant Proteins; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy*
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins