Pharmacokinetics of tryptamide following oral and intraperitoneal administration in rats.
Tryptamide, either suspended in 1% methylcellulose or dissolved in polyethyleneglycol 400-ethanol-physiological salt solution (4:1:5) was administered po or ip at a dose 25 mg/kg to rats, and blood level of this drug was determined by HPLC method. The obtained results were used to construct the semilogarithmic plots of tryptamide concentration vs. time and pharmacokinetic parameters of tryptamide were calculated. We found that tryptamide undergoes fast absorption (t 1/2 = 4.92-17.5 min) and elimination (t 1/2 = 55.72-74.52 min), can reach C(max) values (11-13 microg/cm3) after 30 min, and gives AUC values in the range of 21.40-27.30 (microg x h/cm3).
Szumiło
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Department of Inorganic and Analytical Chemistry, School of Medicine, Lublin, Poland.
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D007274:Injections, Intraperitoneal; D008297:Male; D009536:Niacinamide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D014363:Tryptamines / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014363:Tryptamines; D009536:Niacinamide; C057564:tryptamide