Behavioural management of antipsychotic-induced weight gain: a review.
OBJECTIVE
Although psychiatrists are aware of weight gain induced by atypical antipsychotics, only few studies on behavioural interventions in this patient group are published. This review aims to summarize the evidence on effectiveness of behavioural interventions for weight gain in the general population and in-patients treated with atypical antipsychotics.


METHODS
Medline and Cochrane databases search for evidence on effectiveness of behavioural interventions.


RESULTS
In general, behavioural approaches including, diet, exercise and drug treatments may be effective. There were only 13 studies of behavioural interventions for patients taking antipsychotic medication. No study met the criteria for a RCT. Calorie restriction in a controlled ward environment, structured counselling combined with cognitive behavioural therapy and counselling on life style and provision of rewards may potentially lead to weight loss.


CONCLUSIONS
Currently only limited, methodologically flawed, evidence is available that behavioural interventions in overweight patients treated with antipsychotics, although intuitively appealing, actually work.
Werneke
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Centre for the Economics in Mental Health, Institute of Psychiatry, Maudsley Hospital, London, UK. ursula.werneke@elcmht.nhs.uk
Taylor
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D
Sanders
T A B
TA
Wessely
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S
D014150:Antipsychotic Agents / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy; D003376:Counseling; D004032:Diet; D019317:Evidence-Based Medicine; D015444:Exercise; D006801:Humans; D009765:Obesity / Q000139:chemically induced* / Q000628:therapy*; D015430:Weight Gain
D014150:Antipsychotic Agents