title: Successful intracytoplasmic sperm injection after failed in vitro fertilization due to multipronuclear oocytes.
abstract: OBJECTIVE
  To report a case of IVF with apparently normal female and male gametes that resulted in the development of only multipronuclear oocytes (instead of oocytes containing two pronuclei) and was successfully treated with ICSI.
  
  
  METHODS
  Case report.
  
  
  METHODS
  A university hospital.
  
  
  METHODS
  A 35-year-old woman with unexplained infertility and her partner, a 38-year-old man with normozoospermia.
  
  
  METHODS
  Intracytoplasmic sperm injection.
  
  
  METHODS
  Oocyte fertilization and pregnancy.
  
  
  RESULTS
  Normal fertilization and an ongoing pregnancy occurred after transfer of two embryos.
  
  
  CONCLUSIONS
  Although the usual indication for ICSI is male subfertility, it can also be used to successfully treat oocyte defects.
authors.affiliation: Department of Reproductive Medicine, Leiden University Medical Centre, Leiden, The Netherlands. l.a.j.van_der_westerlaken@lumc.nl
authors.forename: Lucette
authors.initials: L
authors.lastname: van der Westerlaken
authors.forename: Frans
authors.initials: F
authors.lastname: Helmerhorst
authors.forename: Harjo
authors.initials: H
authors.lastname: Verburg
authors.forename: Nico
authors.initials: N
authors.lastname: Naaktgeboren
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008297:Male; D009865:Oocytes / Q000648:ultrastructure*; D011247:Pregnancy; D019233:Retreatment; D020554:Sperm Injections, Intracytoplasmic; D017211:Treatment Failure