Genital human papillomavirus genotyping by HPV oligonucleotide microarray in Korean commercial sex workers.
Because of the diversity in human papillomavirus (HPV) distribution, according to the population and region, detailed investigations of HPV genotypes are important in designing more effective HPV vaccines for any given country. HPV DNA oligonucleotide microarray was used to investigate the distribution of HPV genotypes among commercial sex workers. The prevalence of HPV in Korean commercial sex workers was 47%, with HPV-16 and HPV-51 as the dominant genotypes. HPV subtypes in 148 commercial sex workers comprised 70 with one genotype, 42 with two genotypes, 17 with three genotypes, and 19 with four or more genotypes. HPV-40, the most dominant low-risk genotype, was not detected in single-infection commercial sex workers. All women with multiple infections of low-risk genotypes had the HPV-40 genotype. This molecular epidemiological study of genital HPV will be useful for the development of a favorable strategy to prevent the spread of this potentially serious infection.
Choi
Byeong-Sun
BS
Center for AIDS Research, Department of Virology, National Institute of Health, #5 Nokbun-dong, Eunpyung-gu, Seoul, Korea 122-701, Republic of Korea.
Kim
Okjin
O
Park
Mi Sun
MS
Kim
Ki Soo
KS
Jeong
Jeongmi Kim
JK
Lee
Joo-Shil
JS
D000293:Adolescent; D000328:Adult; D002584:Cervix Uteri / Q000821:virology*; D005260:Female; D005838:Genotype; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D011477:Sex Work; D013048:Specimen Handling / Q000379:methods