title: Muraymycins, novel peptidoglycan biosynthesis inhibitors: synthesis and SAR of their analogues.
abstract: A series of Muraymycin analogues was synthesized. These analogues showed excellent antimicrobial activity against gram-positive organisms. These analogues also showed excellent inhibitory activity against the target peptidoglycan biosynthesis enzyme MraY, the cell membrane associated transglycosylase responsible for the formation of Lipid II.
authors.affiliation: Chemical Sciences and Infectious Diseases, Wyeth Research, Pearl River, NY 10965, USA. yamashita@wyeth.com
authors.forename: Ayako
authors.initials: A
authors.lastname: Yamashita
authors.forename: Emily
authors.initials: E
authors.lastname: Norton
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Petersen
authors.forename: Beth A
authors.initials: BA
authors.lastname: Rasmussen
authors.forename: Guy
authors.initials: G
authors.lastname: Singh
authors.forename: Youjin
authors.initials: Y
authors.lastname: Yang
authors.forename: Tarek S
authors.initials: TS
authors.lastname: Mansour
authors.forename: Douglas M
authors.initials: DM
authors.lastname: Ho
mesh_terms: D008826:Microbial Sensitivity Tests; D009711:Nucleotides; D010455:Peptides; D010457:Peptidoglycan / Q000031:analogs & derivatives* / Q000096:biosynthesis* / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014508:Urea
chemical_list: D009711:Nucleotides; D010455:Peptides; D010457:Peptidoglycan; C475707:muraymycin A3; D014508:Urea