Cholesterol uptake in adrenal and gonadal tissues: the SR-BI and 'selective' pathway connection.
A constant supply of cholesterol is needed as a substrate for steroid hormone synthesis in steroidogenic tissues. Although there are three potential sources, which could contribute to the 'cholesterol pool', needed for steroidogenesis (i.e., de novo synthesis, hydrolysis of stored cholesteryl esters and exogenous lipoproteins), current evidence suggests that plasma lipoproteins are the major source of cholesterol for steroid production in adrenal gland, ovary and, under certain conditions, testicular Leydig cells. In many species, steroid producing cells and tissues obtain this lipoprotein-cholesterol by a unique pathway in which circulating lipoproteins bind to the surface of the steroidogenic cells and contribute their cholesteryl esters to the cells by a 'selective' process. This is a process in which cholesterol is selectively absorbed while the lipoprotein remains at the cell surface. The discovery of a specific receptor for this process (scavenger receptor class B, type I, known as SR-BI) has revolutionized our knowledge about the selective uptake pathway. The present review summarizes the functional importance of the selective pathway as a bulk cholesterol delivery system for steroidogenesis, and attempts to detail the expression, regulation and characteristics of SR-BI as it is deployed in steroidogenic systems as a means of achieving cholesterol balance.
Azhar
Salman
S
Geriatric Research, Education and Clinical Center, VA Palo Alto Heath Care System, Palo Alto, California 94304, USA. salman.azhar@med.va.gov
Leers-Sucheta
Susan
S
Reaven
Eve
E
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D018955:CD36 Antigens / Q000502:physiology*; D008076:Cholesterol, HDL / Q000378:metabolism*; D006066:Gonads / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins; D009928:Organ Specificity / Q000502:physiology; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B; D015398:Signal Transduction / Q000502:physiology*
D018955:CD36 Antigens; D008076:Cholesterol, HDL; D008565:Membrane Proteins; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D051116:Receptors, Scavenger; C495124:SCARB1 protein, human; C454739:Scarb1 protein, mouse; D051122:Scavenger Receptors, Class B