[Circulating troponin I assay: uses and misuses in medical practice].
Cardiac troponin I (cTnI) contributes to the modulation of the myocardial contractile function in the troponins complex. The assay of circulating cTnI is highly specific of the cardiac isoform and allows a quantification of the myocardial injury provided that both free and combined cTnI were recognized by the antibodies. The assay is a major contribution to the diagnosis of postoperative cardiac complications through its specificity because peripheral muscle trauma is a confounding factor during this period. Circulating cTnI mirrors the magnitude of an acute circulatory failure whatever the origin (cardiac, hemorrhagic or septic). A positive cTnI assay in an "asymptomatic" patient has to be confirmed and needs some investigations to discard an occult cardiac disease; cTnI has a limited role by itself in predicting mortality and hospital admissions. Circulating cTnI confirms the severity of an acute coronary syndrome and has a level-dependent prognostic value.
Edouard
A
A
Unité de réanimation chirurgicale, centre hospitalier de Bicêtre, Upres EA 3540, faculté de médecine Paris-Sud, 94275 Le Kremlin-Bicêtre cedex, France. alain.edouard@bct.ap-hop-paris.fr
Cosson
C
C
D001681:Biological Assay; D015415:Biomarkers / Q000032:analysis*; D006331:Heart Diseases / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D009200:Myocardial Contraction; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D011183:Postoperative Complications / Q000175:diagnosis*; D019210:Troponin I / Q000097:blood*
D015415:Biomarkers; D019210:Troponin I
Le dosage de la troponine I: intérêt et limites en pratique médicale courante.