title: Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China.
abstract: A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.
authors.affiliation: Department of Microbiology, The University of Hong Kong, University Pathology Building, Queen Mary Hospital, Hong Kong Special Administrative Region, People's Republic of China. yguan@hkucc.hku.hk
authors.forename: Y
authors.initials: Y
authors.lastname: Guan
authors.forename: B J
authors.initials: BJ
authors.lastname: Zheng
authors.forename: Y Q
authors.initials: YQ
authors.lastname: He
authors.forename: X L
authors.initials: XL
authors.lastname: Liu
authors.forename: Z X
authors.initials: ZX
authors.lastname: Zhuang
authors.forename: C L
authors.initials: CL
authors.lastname: Cheung
authors.forename: S W
authors.initials: SW
authors.lastname: Luo
authors.forename: P H
authors.initials: PH
authors.lastname: Li
authors.forename: L J
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Y J
authors.initials: YJ
authors.lastname: Guan
authors.forename: K M
authors.initials: KM
authors.lastname: Butt
authors.forename: K L
authors.initials: KL
authors.lastname: Wong
authors.forename: K W
authors.initials: KW
authors.lastname: Chan
authors.forename: W
authors.initials: W
authors.lastname: Lim
authors.forename: K F
authors.initials: KF
authors.lastname: Shortridge
authors.forename: K Y
authors.initials: KY
authors.lastname: Yuen
authors.forename: J S M
authors.initials: JS
authors.lastname: Peiris
authors.forename: L L M
authors.initials: LL
authors.lastname: Poon
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000835:Animals, Wild / Q000821:virology*; D000914:Antibodies, Viral / Q000097:blood; D015153:Blotting, Western; D002335:Carnivora / Q000821:virology*; D002681:China; D017934:Coronavirus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D018352:Coronavirus Infections / Q000662:veterinary / Q000821:virology; D004197:Disease Reservoirs; D005243:Feces / Q000821:virology; D016679:Genome, Viral; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D009500:Neutralization Tests; D009666:Nose / Q000821:virology; D016366:Open Reading Frames / Q000235:genetics; D010802:Phylogeny; D011110:Polymorphism, Genetic; D020133:Reverse Transcriptase Polymerase Chain Reaction; D045473:Severe acute respiratory syndrome-related coronavirus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D017384:Sequence Deletion; D012689:Sequence Homology, Nucleic Acid; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000235:genetics; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics
chemical_list: D000914:Antibodies, Viral; D008562:Membrane Glycoproteins; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins; D014764:Viral Proteins; C578557:spike glycoprotein, SARS-CoV