title: [Allogenic transplantation studies on human fetal pancreatic nestin positive cells].
abstract: Human fetal pancreatic nestin positive cells cultured in vitro could self assemble to form islet-like cell clusters(ICC). They are multipotential and are capable of generating insulin-producing cells. To investigate their biological character and physiological function in vivo, ICCs were implanted into NOD-Scid mice subcapsularly. The results showed that: (1) Neovascularizations were observed in implant sites. (2) Blood glucose levels of diabetic mice were reduced markedly after implantation of ICCs. (3) ICCs in non-diabetic mice proliferated abnormally and infiltrated into renal parenchyma with many cell structures formed.
authors.affiliation: Department of Cell Biology, Shanghai Second Medical University, Shanghai 200025.
authors.forename: Hai Xia
authors.initials: HX
authors.lastname: Huang
authors.forename: Xin Zhi
authors.initials: XZ
authors.lastname: Huang
authors.forename: Xin Yu
authors.initials: XY
authors.lastname: Chen
authors.forename: Yu Ying
authors.initials: YY
authors.lastname: Chen
authors.forename: Xue Ming
authors.initials: XM
authors.lastname: Tang
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D003921:Diabetes Mellitus, Experimental / Q000601:surgery*; D005333:Fetus / Q000166:cytology; D006801:Humans; D007381:Intermediate Filament Proteins / Q000378:metabolism*; D007515:Islets of Langerhans / Q000166:cytology; D016381:Islets of Langerhans Transplantation; D051379:Mice; D016513:Mice, SCID; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D064231:Nestin; D010179:Pancreas / Q000166:cytology* / Q000378:metabolism; D033581:Stem Cell Transplantation; D014183:Transplantation, Heterologous
chemical_list: D007381:Intermediate Filament Proteins; C577484:NES protein, human; D009419:Nerve Tissue Proteins; C577485:Nes protein, mouse; D064231:Nestin