title: Association between dopamine receptor D1 gene DdeI polymorphism and sensation seeking in alcohol-dependent men.
abstract: BACKGROUND
  Among genetic and biopsychological factors involved in alcohol-dependence vulnerability, dopamine receptor subtypes genes and temperament's dimensions, such as sensation seeking, have been particularly incriminated. Moreover, it is suggested that higher levels of sensation seeking could be associated with a modification of sensitivity to dopamine in postsynaptic receptors.
  
  
  METHODS
  We investigated whether the DRD1 DdeI polymorphism could be associated with the sensation-seeking level among a sample of 72 alcohol-dependent male and female patients. Analyses of variance were performed to test for an effect between the DRD1 DdeI genotypes and sensation-seeking scores according to the 40-item Zuckerman scale.
  
  
  RESULTS
  When comparing the DRD1 DdeI genotypes and the Zuckerman scores, we found a significant association only in men (p = 0.01).
  
  
  CONCLUSIONS
  That is the first report of a male limited association between the DRD1 gene polymorphism and sensation-seeking score in alcohol-dependent subjects.
authors.affiliation: Department of Psychiatry, Albert Chenevier Hospital, France. frederic.limosin@ach.ap-hop-paris.fr
authors.forename: Frédéric
authors.initials: F
authors.lastname: Limosin
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Loze
authors.forename: Frédéric
authors.initials: F
authors.lastname: Rouillon
authors.forename: Jean
authors.initials: J
authors.lastname: Adès
authors.forename: Philip
authors.initials: P
authors.lastname: Gorwood
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000235:genetics*; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D015252:Deoxyribonucleases, Type II Site-Specific / Q000235:genetics*; D005106:Exploratory Behavior / Q000502:physiology*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D012727:Sex Characteristics; D018709:Statistics, Nonparametric
chemical_list: D017447:Receptors, Dopamine D1; C027908:endodeoxyribonuclease DdeI; D015252:Deoxyribonucleases, Type II Site-Specific