title: [Investigations on the stability of therapeutic drugs derived from imidazole. XII. Qualitative and quantitative stability evaluation of phentolamine hydrochloride solutions].
abstract: Hydrolysis of phentolamine hydrochloride in aqueous solutions, and at pH 1.0 and pH 8.0 was studied by means of thin-layer chromatography. A spectrophotometric method for quantitative assessment of phentolamine hydrochloride hydrolysis has been elaborated, and thermodynamic parameters of this reaction were determined.
authors.affiliation: Katedra i Zakład Chemii Farmaceutycznej Wydziału Farmaceutycznego Akademii Medycznej w Gdańsku, Al. K.Marksa 107, 80-416 Gdańsk.
authors.forename: I
authors.initials: I
authors.lastname: Grabowska
authors.forename: D
authors.initials: D
authors.lastname: Rajzer
authors.forename: A
authors.initials: A
authors.lastname: Kraczkowska
authors.forename: B
authors.initials: B
authors.lastname: Kremska
mesh_terms: D002855:Chromatography, Thin Layer; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007093:Imidazoles / Q000737:chemistry*; D010646:Phentolamine / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D013053:Spectrophotometry / Q000379:methods; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
chemical_list: D007093:Imidazoles; D012996:Solutions; D014867:Water; C029899:imidazole; D010646:Phentolamine
vernacular_title: Badania trwałości środków leczniczychpochodnych imidazoliny.XII. Jakościowa i ilościowa ocena trwałości roztworów chlorowodorku fentolaminy.