Royal Jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage.
In this study, we investigate the effect of dietary Royal Jelly (RJ) on tissue DNA oxidative damage and on the life span of C3H/HeJ mice. In C3H/HeJ mice that were fed a dietary supplement of RJ for 16 weeks, the levels of 8-hydroxy-2-deoxyguanosine (8-OHdG), a marker of oxidative stress, were significantly reduced in kidney DNA and serum. Secondly, we determined the effect of dietary RJ on the life span in C3H/HeJ mice. The 50% mice survivals of intermediate- (about 6 mg/kg weight) and high-dose groups (about 60 mg/kg weight) were reached at significantly longer times than that of the control group according to the generalized Wilcoxon test (p<0.05). The average survival times were 88 weeks for the control group vs. 79 weeks for the low-dose group (about 0.6 mg/kg weight), 112 weeks for the intermediate-dose group and 110 weeks for the high-dose group, respectively, showing that RJ extended the average survival time by about 25% compared to the control group. However, RJ did not extend the total life span. These results indicated that dietary RJ increased the average life span of C3H/HeJ mice, possibly through the mechanism of reduced oxidative damage.
Inoue
Shin-ichiro
S
Fujisaki Institute, Hayashibara Biochemical Laboratories, Inc, 675-1 Fujisaki, Okayama 702-8006, Japan. fujisaki@hayashibara.co.jp
Koya-Miyata
Satomi
S
Ushio
Shimpei
S
Iwaki
Kanso
K
Ikeda
Masao
M
Kurimoto
Masashi
M
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000375:Aging / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001516:Bees; D004249:DNA Damage / Q000187:drug effects*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D019587:Dietary Supplements; D005227:Fatty Acids / Q000494:pharmacology*; D008136:Longevity / Q000187:drug effects*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D018384:Oxidative Stress / Q000187:drug effects; D015996:Survival Rate; D000099219:Royal Jelly
D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; D005227:Fatty Acids; D000099219:Royal Jelly