title: [Evaluation of the primary diagnosis with a CAD-system in mammography].
abstract: OBJECTIVE
  To assess the capability of the computer assisted detection (CAD) system to classify calcifications that are histologically verified as malignant and benign or are proven benign by magnification and follow up mammography.
  
  
  METHODS
  Three groups of microcalcifications (MC) with and without associated masses were enrolled in the study. The cancer group included 141 screen-detected breast cancer cases. One benign group comprised 109 cases with histologically benign specimens obtained through a minimally invasive breast biopsy. A second benign group included 72 lesions with MC that appeared benign on magnification/compression views and were confirmed to be benign on follow-up mammograms over a period of at least 1.5 years. All mammograms were evaluated with a CAD system (Second Look version 3.5, CADx Medical Systems, Canada).
  
  
  RESULTS
  CAD correctly detected 125 of 141 (89 %) cancer cases. Of the 16 false negative cases, CAD marked the location of the MC (which were associated with malignant mass) with a mass mark in 12 cases. For benign cases, CAD did not correctly mark the microcalcifications in 59 of the 109 lesions confirmed benign histologically (54.1 %) and in 39 of the 72 lesions established benign mammographically (54.2 %). Adenosis introduced the highest rate of falsely marked microcalcifications (62 %).
  
  
  CONCLUSIONS
  Due to its limited specificity, CAD can still not be recommended for the primary classification of microcalcifications as malignant or benign. Nevertheless, the low false negative rate and rather high detection rate of malignant findings indicate some value of CAD for an independent second reading.
authors.affiliation: Institut für Diagnostische und Interventionelle Radiologie, Friedrich-Schiller-Universität Jena. ansgar.malich@med.uni-jena.de
authors.forename: A
authors.initials: A
authors.lastname: Malich
authors.forename: D
authors.initials: D
authors.lastname: Vogel
authors.forename: M
authors.initials: M
authors.lastname: Facius
authors.forename: C
authors.initials: C
authors.lastname: Marx
authors.forename: M G
authors.initials: MG
authors.lastname: Freesmeyer
authors.forename: D
authors.initials: D
authors.lastname: Sauner
authors.forename: A
authors.initials: A
authors.lastname: Hansch
authors.forename: S O R
authors.initials: SO
authors.lastname: Pfleiderer
authors.forename: M
authors.initials: M
authors.lastname: Fleck
authors.forename: W A
authors.initials: WA
authors.lastname: Kaiser
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging; D002288:Adenocarcinoma, Mucinous / Q000000981:diagnostic imaging; D001706:Biopsy; D001940:Breast / Q000473:pathology; D001941:Breast Diseases / Q000000981:diagnostic imaging* / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D005260:Female; D018226:Fibroadenoma / Q000000981:diagnostic imaging; D005348:Fibrocystic Breast Disease / Q000000981:diagnostic imaging; D005355:Fibrosis / Q000000981:diagnostic imaging; D006801:Humans; D006965:Hyperplasia; D008327:Mammography; D010212:Papilloma / Q000000981:diagnostic imaging; D011857:Radiographic Image Interpretation, Computer-Assisted; D012189:Retrospective Studies
vernacular_title: Evaluation der Primärbefundung durch ein CAD-System in der Mammadiagnostik.