title: Synthesis of a novel family of diterpenes and their evaluation as anti-inflammatory agents.
abstract: The synthesis and biological evaluation of a new family of diterpenes, represented by structures 2 and 3, is presented. These compounds constitute isomeric analogues of acanthoic acid (1) and were examined as potent anti-inflammatory agents. Among them, methyl ester 12 exhibited a low non-specific cytotoxicity, inhibited TNF-alpha synthesis and displayed good specificity in suppressing cytokine expression.
authors.affiliation: Department of Chemistry and Biochemistry, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.
authors.forename: Thanh
authors.initials: T
authors.lastname: Lam
authors.forename: Taotao
authors.initials: T
authors.lastname: Ling
authors.forename: Chinmay
authors.initials: C
authors.lastname: Chowdhury
authors.forename: Ta-Hsiang
authors.initials: TH
authors.lastname: Chao
authors.forename: F R
authors.initials: FR
authors.lastname: Bahjat
authors.forename: G K
authors.initials: GK
authors.lastname: Lloyd
authors.forename: Lyle L
authors.initials: LL
authors.lastname: Moldawer
authors.forename: Michael A
authors.initials: MA
authors.lastname: Palladino
authors.forename: Emmanuel A
authors.initials: EA
authors.lastname: Theodorakis
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D028001:Eleutherococcus; D006801:Humans; D010936:Plant Extracts / Q000138:chemical synthesis / Q000494:pharmacology; D018517:Plant Roots; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha