title: Additive effect of bunazosin on intraocular pressure when topically added to treatment with latanoprost in patients with glaucoma.
abstract: OBJECTIVE
  To investigate whether an alpha-1 blocker, bunazosin, has an additive effect on lowering intraocular pressure (IOP) when topically added to latanoprost treatment in patients with glaucoma.
  
  
  METHODS
  Bunazosin twice a day was added topically to the treatment for 12 patients with glaucoma who had been instilling latanoprost once a day for more than 1 month. IOP was measured and adverse events were checked 2, 4 and 8 weeks after the addition of bunazosin to their treatment.
  
  
  RESULTS
  One of the 12 patients dropped out in the course of the study. Therefore, 11 patients were included for the analysis of IOP, and 12 for the analysis of adverse events. IOPs were decreased significantly (P=.008, Wilcoxon signed rank test) from 18.2+/-3.4 mm Hg to 16.6+/-3.5 mm Hg 8 weeks after the addition of bunazosin. Adverse events were seen in 5 of the 12 patients.
  
  
  CONCLUSIONS
  Bunazosin has an additive effect on lowering IOP when topically added to latanoprost treatment in glaucoma patients.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Tsukamoto
authors.forename: Koji
authors.initials: K
authors.lastname: Jian
authors.forename: Michiya
authors.initials: M
authors.lastname: Takamatsu
authors.forename: Koji
authors.initials: K
authors.lastname: Okada
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mukai
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Tsumamoto
authors.forename: Hiromu K
authors.initials: HK
authors.lastname: Mishima
mesh_terms: D000287:Administration, Topical; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D000368:Aged; D000369:Aged, 80 and over; D004359:Drug Therapy, Combination; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage* / Q000009:adverse effects; D011799:Quinazolines / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000317:Adrenergic alpha-Antagonists; D011461:Prostaglandins F, Synthetic; D011799:Quinazolines; D000077338:Latanoprost; C018176:bunazosin