Thermo- and pH-responsive biodegradable poly(alpha-N-substituted gamma-glutamine)s.
New double stimuli-responsive poly(alpha-N-substituted gamma-glutamine) has been developed, which was synthesized by the reaction of poly(gamma-glutamic acid) with amino alcohols. Appropriate combinations of the amino alcohols provided the biodegradable poly(amino acid) exhibiting a sharp lower critical solution temperature (LCST) in water. Furthermore, the phase transition temperature was highly sensitive to pH changes.
Tachibana
Yoichi
Y
Department of Materials Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
Kurisawa
Motoichi
M
Uyama
Hiroshi
H
Kobayashi
Shiro
S
D000605:Amino Alcohols / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D010455:Peptides / Q000737:chemistry*; D044367:Phase Transition; D012995:Solubility; D013696:Temperature
D000605:Amino Alcohols; D001672:Biocompatible Materials; D010455:Peptides; C097188:polyglutamine