Neuroprotective activity of p-terphenyl leucomentins from the mushroom Paxillus panuoides.
The neuroprotective mechanism of p-terphenyl leucomentins from the mushroom Paxillus panuoides was studied. Leucomentins showed potent inhibition of lipid peroxidation and H2O2 neurotoxicity, but free from any role as reactive oxygen species (ROS) scavengers. Iron-mediated oxidative damage has been implicated in these processes, as a provider of ROS via iron. Leucomentins can chelate iron when DNA is present with iron and H2O2, and so inhibiting DNA single strand breakage. These results suggest that the neuroprotective action of leucomentins is dependent on their ability to chelate iron.
Lee
In-Kyoung
IK
Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon 305-600, Korea.
Yun
Bong-Sik
BS
Kim
Jong-Pyung
JP
Ryoo
In-Ja
IJ
Kim
Young-Ho
YH
Yoo
Ick-Dong
ID
D000363:Agaricales / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D004249:DNA Damage / Q000187:drug effects; D004852:Epoxy Compounds / Q000737:chemistry / Q000494:pharmacology*; D005296:Ferrous Compounds / Q000378:metabolism / Q000633:toxicity; D005609:Free Radicals / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism / Q000633:toxicity; D006861:Hydrogen Peroxide / Q000378:metabolism / Q000633:toxicity; D007502:Iron Chelating Agents / Q000737:chemistry / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D016202:N-Methylaspartate / Q000378:metabolism / Q000633:toxicity; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013730:Terphenyl Compounds / Q000737:chemistry / Q000494:pharmacology*
D000475:Alkenes; D004852:Epoxy Compounds; D005296:Ferrous Compounds; D005609:Free Radicals; D007502:Iron Chelating Agents; D018696:Neuroprotective Agents; D013730:Terphenyl Compounds; C414149:leucomentin-5; C414148:leucomentin-6; D018698:Glutamic Acid; D016202:N-Methylaspartate; D006861:Hydrogen Peroxide