Chlorocoulometric determination of primaquine.
A method for the coulometric determination of primaquine is presented. The coulometric titration is carried out in the anode compartment, in the supporting electrolyte consisting of 0.5 M sulfuric acid and 0.2 M sodium chloride solution, in the presence of methyl orange as indicator. The electrogenerated chlorine reacts with primaquine in a 2:1 molar stoichiometric ratio. Accurate and reproducible results have been obtained in the assay of small amounts of primaquine. One coulomb corresponds to 1.1797 mg of primaquine diphosphate.
Berka
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Department of Analytical Chemistry, Faculty of Natural Science, Charles University Prague, Czechoslovakia.
Nikolić
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Velasević
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K
D000962:Antimalarials / Q000032:analysis*; D002713:Chlorine / Q000737:chemistry; D004563:Electrochemistry; D007202:Indicators and Reagents; D011319:Primaquine / Q000031:analogs & derivatives / Q000032:analysis*; D015203:Reproducibility of Results
D000962:Antimalarials; D007202:Indicators and Reagents; D002713:Chlorine; D011319:Primaquine