Effect of a bioresorbable membrane on postoperative adhesions and wound healing.
OBJECTIVE
To study the effect of Seprafilm (Genzym Corporation, Cambridge, Massachusetts), a biosorbable membrane, on adhesion formation and injury recovery.


METHODS
Twenty female Wistar-albino rats were divided into two groups of 10 each. The right uterine horns of all rats were incised longitudinally and then stitched. While no procedure was conducted in group I (control group), in group II (Seprafilm group) this incision line was wrapped with Seprafilm. The rats were reoperated on day 7 after the first operation. The results were assessed using the Mann-Whitney U (MWU) test, and P < .05 was considered significant.


RESULTS
The adhesion score in group I was higher than in group II (3.6 +/- 0.1 vs. 0.3 +/- 0.1; P = .000, MWU test). In the histopathologic examination performed to examine injury recovery, the measured bursting pressures and hydroxyproline levels were similar in the two groups.


CONCLUSIONS
Seprafilm prevented postoperative adhesions without affecting injury recovery and thus can be used reliably.
Bülbüller
Nurullah
N
Departments of General Surgery, Obstetrics and Gynecology, Pathology and Biochemistry, Medical School, Firat Universitesi Firat Tip Merkezi, Genel Cerrahi Anabilim Dali, 23200 Elaziğ, Turkey. nbulbuller@yahoo.com
Sapmaz
Ekrem
E
Akpolat
Nusret
N
Ustündağ
Bilal
B
Kirkil
Cüneyt
C
D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D005260:Female; D006820:Hyaluronic Acid; D008567:Membranes, Artificial; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013526:Surgical Mesh; D013997:Time Factors; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control*; D014599:Uterus / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects
D001672:Biocompatible Materials; D008567:Membranes, Artificial; C118198:Seprafilm; D006820:Hyaluronic Acid