title: Titanium cages in the surgical treatment of severe vertebral osteomyelitis.
abstract: The role of spinal implants in the presence of infection is critically discussed. In this study 20 patients with destructive vertebral osteomyelitis were surgically treated with one-stage posterior instrumentation and fusion and anterior debridement, decompression and anterior column reconstruction using an expandable titanium cage filled with morsellised autologous bone graft. The patients' records and radiographs were retrospectively analysed and follow-up clinical and radiographic data obtained. At a mean follow-up of 23 months (range 12-56 months) all cages were radiographically fused and all infections eradicated. There were no cases of cage dislocation, migration or subsidence. Local kyphosis was corrected from 9.2 degrees (range -20 degrees to 64 degrees ) by 9.4 degrees to -0.2 degrees (range -32 degrees to 40 degrees ) postoperatively and lost 0.9 degrees during follow-up. All five patients with preoperative neurological deficits improved to Frankel score D or E. Patient-perceived disability caused by back pain averaged 7.9 (range 0-22) in the Roland-Morris score at follow-up. In cases of vertebral osteomyelitis with severe anterior column destruction the use of titanium cages in combination with posterior instrumentation is effective and safe and offers a good alternative to structural bone grafts. Further follow-up is necessary to confirm these early results.
authors.affiliation: Department of Orthopedics, University Hospital of Münster, Albert-Schweitzer-Str 33, 48149 Münster, Germany. liljenqv@uni-muenster.de
authors.forename: U
authors.initials: U
authors.lastname: Liljenqvist
authors.forename: T
authors.initials: T
authors.lastname: Lerner
authors.forename: V
authors.initials: V
authors.lastname: Bullmann
authors.forename: L
authors.initials: L
authors.lastname: Hackenberg
authors.forename: H
authors.initials: H
authors.lastname: Halm
authors.forename: W
authors.initials: W
authors.lastname: Winkelmann
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001416:Back Pain / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D016268:Internal Fixators / Q000592:standards / Q000706:statistics & numerical data*; D007738:Kyphosis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology; D011859:Radiography; D012189:Retrospective Studies; D013122:Spinal Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D013123:Spinal Fusion / Q000295:instrumentation* / Q000379:methods* / Q000706:statistics & numerical data; D013131:Spine / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D014025:Titanium / Q000592:standards / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D014025:Titanium