Effects of aqueous extracts of Satureja hortensis L. on rhinosinusitis treatment in rabbit.
Satureja hortensis L. (Lamiaceae) is an annual herb that used as traditional folk medicine in Eastern Anatolia region of Turkey for treatment of different infectious diseases and disorders. This study was designated to investigate anti-inflammatory effect of aqueous extract (250 mg/kg) of Satureja hortensis. Therapeutic potential of Satureja hortensis as an anti-inflammatory agent was examined by measurement of NO* metabolites and histological changes in a rabbit model of rhinosinusitis. The results showed that both activity of NOS enzyme and concentration of NO* metabolites were significantly reduced by topical administration of Satureja hortensis extract. Histological examination demonstrated no edema and/or reduced inflammation in therapy group as compared to the control. Thus, the data suggest Satureja hortensis extract may have the potential to be used as anti-inflammation agent, and can be used in the treatment of rhinosinusitis diseases.
Uslu
Celil
C
Department of Otolaryngology, School of Medicine, Ataturk University, 25240 Erzurum, Turkey. celiluslu@hotmail.com
Murat Karasen
R
R
Sahin
Fikrettin
F
Taysi
Seyithan
S
Akcay
Fatih
F
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D011817:Rabbits; D012220:Rhinitis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D031362:Satureja / Q000737:chemistry*; D012852:Sinusitis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014867:Water / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D014867:Water; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase