Mucin/poly(acrylic acid) interactions: a spectroscopic investigation of mucoadhesion.
Studies using infrared, (1)H and (13)C nuclear magnetic resonance, and X-ray photoelectron spectroscopies and differential scanning calorimetry support the hypothesis that hydrogen bonds, formed between the carboxylic acid functionality of the mucoadhesive material poly(acrylic acid) and the glycoprotein component of mucus, play a significant role in the process of mucoadhesion. There are fewer H-bonded interactions between the components than within the bulk of the pure mucoadhesive agent. The pH of the medium influences the structures of both the poly(acrylic acid) and the mucus, which, in turn, determine the nature and the extent of mucoadhesive interactions.
Patel
Minesh M
MM
School of Pharmacy and Biomedical Sciences, University of Portsmouth, White Swan Road, Portsmouth PO1 2DT, UK.
Smart
John D
JD
Nevell
Thomas G
TG
Ewen
Richard J
RJ
Eaton
Peter J
PJ
Tsibouklis
John
J
D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D002152:Calorimetry, Differential Scanning; D006860:Hydrogen Bonding; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing / Q000379:methods*; D015394:Molecular Structure; D009093:Mucus / Q000737:chemistry* / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013057:Spectrum Analysis; D013270:Stomach; D013552:Swine; D000267:Tissue Adhesions; D014965:X-Rays
D000180:Acrylic Resins; C006903:carbopol 940