title: Pharmacokinetics of sevoflurane uptake into the brain and body.
abstract: The aim of this study was to investigate the pharmacokinetics of sevoflurane uptake into the brain and body by comparing sevoflurane concentrations in internal jugular-bulb blood (Jsev), arterial blood (Asev) and pulmonary arterial blood (PAsev) over a fixed inspired sevoflurane concentration. Ten patients (aged 51-73 years), undergoing coronary artery bypass grafting surgery were enrolled in this study. They were anaesthetised using a constant 3.5% inspired sevoflurane concentration (CIsev) during the first hour of anaesthesia. During constant volume-controlled ventilation, we measured CIsev and end-tidal sevoflurane (CEsev) using infrared analysis. The sevoflurane concentration in the blood was analysed using gas chromatography, and cardiac output was measured using an Opti-Q pulmonary artery catheter. We found that it took 40 min for the brain concentration to equilibrate with arterial blood (Asev). Both CIsev-CEsev and Asev-PAsev gradients persisted during the study period. There was no further uptake of sevoflurane into the brain after 40 min; however, there was near-constant uptake into the body.
authors.affiliation: Department of Anaesthesiology, Tri-Service General Hospital/National Defense Medical Center, Room 8113, no. 161, Sec. 6, Minchuan E. Road, Taipei, Taiwan.
authors.forename: C C
authors.initials: CC
authors.lastname: Lu
authors.forename: C S
authors.initials: CS
authors.lastname: Tsai
authors.forename: S T
authors.initials: ST
authors.lastname: Ho
authors.forename: W Y
authors.initials: WY
authors.lastname: Chen
authors.forename: C S
authors.initials: CS
authors.lastname: Wong
authors.forename: J J
authors.initials: JJ
authors.lastname: Wang
authors.forename: O Y P
authors.initials: OY
authors.lastname: Hu
authors.forename: C Y
authors.initials: CY
authors.lastname: Lin
mesh_terms: D000368:Aged; D000768:Anesthesia, General; D018685:Anesthetics, Inhalation / Q000097:blood / Q000493:pharmacokinetics*; D001921:Brain / Q000378:metabolism*; D002849:Chromatography, Gas; D001026:Coronary Artery Bypass; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000097:blood / Q000493:pharmacokinetics*; D008875:Middle Aged; D000077149:Sevoflurane; D014018:Tissue Distribution
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane