[Hyperhomocysteinemia as risk factor in a Mexican population].
Hyperhomocysteinemia is considered one of the emerging risk factors for the development of coronary artery disease (CAD). In order to know the prevalence of this metabolic disorder in a Mexican population with early CAD (< 50 years), we studied a group of these patients and compared the levels of homocysteine with a group of patients, paired by age and gender, without angiographic evidence of coronary atherosclerosis. Preliminary results show that the population with early CAD has more traditional risk factors, specially diabetes mellitus, and higher levels of homocysteine in plasma. Moreover there is a genetic factor with higher incidence of a TT homozygotic mutation of the MTHFR that increases homocysteine because of an altered folate metabolism.
Morales
J J
JJ
Departamento de Genética, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D.F.
Sánchez
B
B
Verdejo
J
J
Ponce de León
S
S
Mutchinick
O M
OM
D000328:Adult; D000368:Aged; D003324:Coronary Artery Disease / Q000209:etiology*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications*; D008800:Mexico; D008875:Middle Aged; D012307:Risk Factors
La hiperhomocisteinemia como factor de riesgo en una población mexicana.