title: Hawthorn extracts inhibit LDL oxidation.
abstract: Polyphenol-rich diet decreases cardiovascular risk. LDL oxidation is the primary event in atherosclerosis plaque formation and antioxidants such as polyphenols were shown to inhibit LDL oxidation and atherosclerosis development. Hawthorn (Crataegus) and derived pharmaceuticals are rich in polyphenols and already prescribed to treat moderate heart failure, nervousness and sleep disorders. Extracts either from fresh plant parts (flower buds, flowers, young leaves or green fruits) or from dried pharmaceutical parts (flowers and flowering tops) were previously shown to be effective inhibitors of lipoperoxidation and scavengers of oxygen species. In this study, the capacity of total and ethyl-acetate extracts from dried pharmaceutical flowers, tops and fruits to inhibit Cu(2+)-induced LDL oxidation was tested. This capacity was positively linked to their content in total polyphenols, proanthocyanidins (global and oligomeric forms), as well as to their content in two individual phenolics: a flavanol, the dimeric procyanidin B2 and a flavonol glycoside, hyperoside. Flavanol-type phenolics showed to be higher active than the majority of the flavonoids tested in inhibiting Cu(2+)-induced LDL peroxidation. This study suggests that hawthorn could be a source of polyphenols able to inhibit LDL oxidation.
authors.affiliation: Laboratoire de Pharmacognosie, Faculté de Pharmacie, Institut Pasteur, Lille, France.
authors.forename: C
authors.initials: C
authors.lastname: Quettier-Deleu
authors.forename: G
authors.initials: G
authors.lastname: Voiselle
authors.forename: J C
authors.initials: JC
authors.lastname: Fruchart
authors.forename: P
authors.initials: P
authors.lastname: Duriez
authors.forename: E
authors.initials: E
authors.lastname: Teissier
authors.forename: F
authors.initials: F
authors.lastname: Bailleul
authors.forename: J
authors.initials: J
authors.lastname: Vasseur
authors.forename: F
authors.initials: F
authors.lastname: Trotin
mesh_terms: D000085:Acetates; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D044946:Biflavonoids; D002392:Catechin / Q000737:chemistry / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003124:Colorimetry; D003300:Copper / Q000737:chemistry; D027825:Crataegus / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry / Q000378:metabolism*; D010084:Oxidation-Reduction; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D044945:Proanthocyanidins; D012997:Solvents
chemical_list: D000085:Acetates; D000975:Antioxidants; D044946:Biflavonoids; D005419:Flavonoids; D008077:Lipoproteins, LDL; D010636:Phenols; D010936:Plant Extracts; D044945:Proanthocyanidins; D012997:Solvents; C479580:procyanidin B2; C017674:procyanidin; C007650:ethyl acetate; D003300:Copper; D002392:Catechin