[Study of levels of IL-18 and IFN-Gamma in serum of patients with condyloma acuminatum].
To study the role of interleukin(IL)18 and interferon gamma (IFN-Gamma) in the pathogenesis of condyloma acuminatum(CA).



Double antibody sandwich ELISA was used to measure the levels of IL-18 and IFN-Gamma in serum of 30 cases of CA.



The serum levels of IL-18 and IFN-Gamma of the CA patients were significantly higher than those of normal controls IL-18 132.00 +/-52.92 microg/L compared with 50.79 +/- 23.48 microg/L, P<0.01 IFN-Gamma:80.83 +/-20.46 microg/L compared with 20.71 +/-11.18 microg/L P <0.01) and IL-18 levels were positively correlated with IFN-Gamma concentrations (r=0.754, t=6.081, P <0.01).



These data suggest that during infection of human papilloma viruses, anti-infective immune responses are activated.
Liu
Guo-ying
GY
The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
Yao
Hang-ping
HP
D000328:Adult; D003218:Condylomata Acuminata / Q000276:immunology*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D008875:Middle Aged
D020382:Interleukin-18; D007371:Interferon-gamma