[Pragmatic clinical trials: an option in the construction of health-related evidence].
The authors present and discuss the potential of pragmatic clinical trials as an alternative to both explanatory trials and observational studies to support the use of therapeutic interventions with good evidence. They argue that this strategy, when properly applied, can be a powerful tool to obtain unbiased measures of effectiveness, with simpler logistics and lower costs than in current clinical trials.
Coutinho
Evandro da Silva Freire
Eda S
Departamento de Epidemiologia e Métodos Quantitativos em Saúde, Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, 21041-210, Brasil. evandro@ensp.fiocruz.br
Huf
Gisele
G
Bloch
Katia Vergetti
KV
D002986:Clinical Trials as Topic; D016021:Epidemiologic Studies; D019317:Evidence-Based Medicine; D016032:Randomized Controlled Trials as Topic
Ensaios clínicos pragmáticos: uma opção na construção de evidências em saúde.