title: Synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, an analogue of 15R-lipoxin A4.
abstract: We describe a method for the synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, a compound that has been described as a metabolically stable analogue of 15R-lipoxin A(4).
authors.affiliation: Department of Chemistry, AstraZeneca R&D Wilmington, 1800 Concord Pike, Wilmington, DE 19850, USA. eifion.phillips@astrazeneca.com
authors.forename: Eifion D
authors.initials: ED
authors.lastname: Phillips
authors.forename: Hui-Fang
authors.initials: HF
authors.lastname: Chang
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Holmquist
authors.forename: John P
authors.initials: JP
authors.lastname: McCauley
mesh_terms: D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis*; D044045:Lipoxins / Q000138:chemical synthesis*
chemical_list: D005231:Fatty Acids, Unsaturated; D044045:Lipoxins; C114465:hexadecatetraenoic acid; C040527:lipoxin A4