Haemorrhagic bullae in a case of paroxysmal nocturnal haemoglobinuria.
Paroxysmal nocturnal haemoglobinuria is a clonal stem cell disorder manifesting as haemolysis, bone marrow failure and thrombosis. We report a rare cutaneous manifestation on the trunk of a 40-year-old patient. Skin biopsy revealed the presence of fibrin thrombi in the capillaries. The eruption responded within days after commencing oral corticosteroids.
White
J M L
JM
Department of Dermatology, King's College Hospital, London, UK. jonathanmlwhite@hotmail.com
Watson
K
K
Arya
R
R
du Vivier
A W P
AW
D000328:Adult; D001706:Biopsy / Q000379:methods; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications* / Q000473:pathology; D006470:Hemorrhage / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D012872:Skin Diseases, Vesiculobullous / Q000209:etiology* / Q000473:pathology