title: Prehospital thrombolysis in acute myocardial infarction in a very sparsely inhabited area in northern Norway.
abstract: This study reports the experience gained in prehospital thrombolysis in acute myocardial infarction in a sparsely inhabited remote area of northern Norway. The study was retrospective from 1992 to 1999. The area covered was 49 000 km2, with a population of 75 000. During the study period only one out of 19 municipalities offered prehospital thrombolysis by general practitioners. Treatment was therefore accomplished by the use of an existing anaesthesiologist-manned rescue helicopter in the absence of available alternatives. The objectives were to evaluate whether prehospital thrombolysis was feasible, and if this approach improved access to early thrombolysis. A total of 272 patients with cardiac-related diagnoses were treated; 91 were considered prehospitally to have an acute myocardial infarction. The median delay from the onset of chest pain until first contact with the health system was 4 hours and 6 minutes or 4 hours and 10 minutes. A total of 23 patients were thrombolysed by the rescue anaesthesiologist prehospitally and four by general practitioners, whereas 58 had contraindications, mainly the duration of chest pain being greater than 6 h (24). Twelve of the 23 patients experienced hypotension and arrhythmia after the administration of streptokinase. Prehospital thrombolysis was feasible, but in order to improve access for patients, all general practitioners or ambulance personnel should administer treatment prehospitally. The public should be urged further to make early contact in cases of chest pain.
authors.affiliation: Norwegian Air Ambulance, Banak, Lakselv, Norway.
authors.forename: Per P
authors.initials: PP
authors.lastname: Bredmose
authors.forename: Stein
authors.initials: S
authors.lastname: Høybjør
authors.forename: Karl-Ake
authors.initials: KA
authors.lastname: Sjöborg
authors.forename: Torben
authors.initials: T
authors.lastname: Wisborg
mesh_terms: D017677:Age Distribution; D000368:Aged; D000075202:Contraindications; D004632:Emergency Medical Services / Q000379:methods / Q000706:statistics & numerical data*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control*; D009664:Norway / Q000453:epidemiology; D010351:Patient Discharge / Q000706:statistics & numerical data; D010360:Patient Transfer / Q000706:statistics & numerical data; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D017678:Sex Distribution; D015912:Thrombolytic Therapy / Q000379:methods / Q000706:statistics & numerical data*; D013996:Time and Motion Studies; D014187:Transportation of Patients / Q000706:statistics & numerical data