Preliminary model of fluid and solute distribution and transport during hemorrhage.
The distribution and transport of fluid, ions, and other solutes (plasma proteins and glucose) are described in a mathematical model of unresuscitated hemorrhage. The model is based on balances of each material in both the circulation and its red blood cells, as well as in a whole-body tissue compartment along with its cells. Exchange between these four compartments occurs by a number of different mechanisms. The hemorrhage model has as its basis a validated model, due to Gyenge et al., of fluid and solute exchange in the whole body of a standard human. Hypothetical but physiologically based features such as glucose and small ion releases along with cell membrane changes are incorporated into the hemorrhage model to describe the system behavior, particularly during larger hemorrhages. Moderate (10%-30% blood volume loss) and large (> 30% blood loss) hemorrhage dynamics are simulated and compared with available data. The model predictions compare well with the available information for both types of hemorrhages and provide a reasonable description of the progression of a large hemorrhage from the compensatory phase through vascular collapse.
Gyenge
C C
CC
Department of Physiology, University of Bergen, Arstadveien 19, N 5009 Bergen, Norway.
Bowen
B D
BD
Reed
R K
RK
Bert
J L
JL
D000818:Animals; D001692:Biological Transport; D001786:Blood Glucose / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism; D001826:Body Fluids / Q000378:metabolism*; D003198:Computer Simulation; D004285:Dogs; D045604:Extracellular Fluid / Q000378:metabolism*; D018495:Fluid Shifts; D005947:Glucose / Q000378:metabolism*; D006470:Hemorrhage / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D009994:Osmolar Concentration; D010865:Pilot Projects; D011506:Proteins / Q000378:metabolism*; D012995:Solubility; D012996:Solutions
D001786:Blood Glucose; D001798:Blood Proteins; D011506:Proteins; D012996:Solutions; D005947:Glucose