title: Is there a common mechanism of gastrointestinal nematode expulsion?
abstract: Parasitic gastrointestinal (GI) nematodes are one of the most commonly acquired infections in the world. Although they cause relatively little mortality, infections result in high levels of morbidity that can result in developmental consequences in infected children and cause significant economic loss in infected animals. Over the last 30 years there has been extensive research into the mechanisms controlling the expulsion of gastrointestinal nematodes. Although many of the effector mechanisms that contribute to the loss of the parasite have been defined, we still appear to be some way from understanding the actual cause of parasite loss. Part of this stems from the different responses induced by different gastrointestinal parasites. It is clear that a Th2 response is essential for the expulsion of GI helminths; however, each of the characteristic immunological effector mechanisms induced following infection with these parasites may not be required or may be insufficient in isolation, but together they operate to expel GI helminths. These responses then succeed more efficiently in some cases than in others to induce parasite expulsion. The contribution made by various effector mechanisms to the expulsion of these parasites may therefore be a reflection of both the niche which the parasite inhabits as well as possible evasive/suppressive mechanisms employed by the parasites. In this review the various aspects of parasite expulsion will be described and the controversial issues in the field will be discussed.
authors.affiliation: Department of Immunology, University of Strathclyde, Glasgow, UK. catherine.lawrence@strath.ac.uk
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Lawrence
mesh_terms: D000818:Animals; D004064:Digestive System / Q000469:parasitology*; D006790:Host-Parasite Interactions / Q000276:immunology; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000276:immunology* / Q000469:parasitology; D009348:Nematoda / Q000276:immunology; D009349:Nematode Infections / Q000276:immunology* / Q000469:parasitology; D018418:Th2 Cells / Q000276:immunology*