title: Characterization of the hyporesponsiveness of synovial T-Cells in rheumatoid arthritis: role of chronic oxidative stress.
abstract: It is commonly thought that autoreactive T-cells fulfill a central role in the chronic inflammatory response that occurs in the joints of patients with rheumatoid arthritis (RA). However, the accumulated T-cells in the joints of patients with RA are functionally suppressed compared with peripheral blood T-cells. The mechanism that underlies this synovial T-cell hyporesponsiveness and the possible role of this phenomenon in the pathogenesis of RA is the subject of this article.
authors.affiliation: Department of Rheumatology, Leiden University Medical Center, The Netherlands.
authors.forename: M M
authors.initials: MM
authors.lastname: Maurice
authors.forename: C L
authors.initials: CL
authors.lastname: Verweij
authors.forename: F C
authors.initials: FC
authors.lastname: Breedveld