title: [Physiological and technical limitations of functional magnetic resonance imaging (fMRI)--consequences for clinical use].
abstract: Functional magnetic resonance imaging (fMRI) is the most common noninvasive technique in functional neuroanatomy. The capabilities and limitations of the method will be discussed based on a short review of the current knowledge about the neurovascular relationship. The focus of this article is on current methodical and technical problems regarding fMRI-based detection and localization of neuronal activity. Main error sources and their influence on the reliability and validity of fMRI-methods are presented. Appropriate solution strategies will be proposed and evaluated. Finally, the clinical relevance of MR-based diagnostic methods are discussed.
authors.affiliation: Neurologische Klinik der Charité, Humboldt-Universität Berlin. torsten.wuestenberg@charite.de
authors.forename: T
authors.initials: T
authors.lastname: Wüstenberg
authors.forename: K
authors.initials: K
authors.lastname: Jordan
authors.forename: F L
authors.initials: FL
authors.lastname: Giesel
authors.forename: A
authors.initials: A
authors.lastname: Villringer
mesh_terms: D001927:Brain Diseases / Q000175:diagnosis*; D001932:Brain Neoplasms / Q000175:diagnosis; D002560:Cerebrovascular Circulation; D003704:Dementia / Q000175:diagnosis; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005544:Forecasting; D006439:Hemodynamics; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010100:Oxygen / Q000097:blood; D010690:Phlebography; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D010100:Oxygen
vernacular_title: Physiologische und technische Grenzen der funktionellen Magnetresonanztomographie und die damit verbundenen Konsequenzen für die klinische Anwendung.