High levels of interleukin-1 in patients with endemic pemphigus foliaceus.
Endemic pemphigus foliaceus (EPF) is an autoimmune disease characterized by blister formation with a loss of cohesion and infiltration of inflammatory cells. We observed that supernatants of peripheral blood mononuclear cells from patients produced significantly more interleukin-1beta (IL-1beta) than those from stimulated healthy controls. Furthermore, a Th2 bias was observed in EPF patients when the IL-5/gamma interferon ratio was analyzed. These results indicate that cells from pemphigus patients react with a vigorous proinflammatory response.
Rocha-Rodrigues
Denise Bertulucci
DB
Faculdade de Medicina do Triângulo Mineiro, Uberaba, Minas Gerais, Brazil.
Paschoini
Giovana
G
Pereira
Sanivia Aparecida Lima
SA
dos Reis
Marlene Antonia
MA
Teixeira
Vicente de Paula Antunes
Vde P
Rodrigues Júnior
Virmondes
V
D001327:Autoimmune Diseases / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D007375:Interleukin-1 / Q000096:biosynthesis*; D015848:Interleukin-5 / Q000096:biosynthesis; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D010392:Pemphigus / Q000378:metabolism*; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D016207:Cytokines; D007375:Interleukin-1; D015848:Interleukin-5; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma