title: Persistence of intracranial diastolic flow in transcranial Doppler sonography exploration of patients in brain death.
abstract: OBJECTIVE
  The persistence of cerebral blood flow (CBF) in patients with whole brain death (BD) diagnosis is an unusual phenomenon. We describe patients with whole BD diagnosed despite persistence of intracranial blood flow on transcranial Doppler sonography (TDS).
  
  
  METHODS
  From January 2001 to December 2002, we reviewed the records of 11 patients. Etiology of BD was craniocephalic trauma in 2 cases, schemic cerebrovascular accident (CVA) in 4 cases, Hemorrhagic CVA in 3 cases, subaracnoid hemorrhage in 1 case, and acute hydrocephalus in 1 case. Six patients had a cerebral decompressive mechanism. In all patients, TDS was used to confirm BD after clinical diagnosis. Additionally, all patients underwent an electroencephalogram (EEG). In 3 patients cerebral angiography (CA) and in 2 others radionuclide angiography (RA) with Tc99m HMPAO were done.
  
  
  RESULTS
  All TDS studies showed persistent telediastolic positive flow in at least 1 artery. Because the TDS did not confirm the clinical diagnosis of BD, EEG tests were performed showing silence of bioelectrical activity. Those cases showed CA or RA results with a complete absence of CBF.
  
  
  CONCLUSIONS
  The TDS technique directly evaluates the intracranial but not the intracerebral circulation. For this reason, during the BD diagnosis for patients with previous decompressive techniques, it was possible to find persistence of intracranial telediastolic flow using TDS. In those cases, it is advisable to use other tests to confirm the clinical diagnosis of BD.
authors.affiliation: Transplant Coordination Service, Hospital Clinic Barcelona, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Cabrer
authors.forename: J M
authors.initials: JM
authors.lastname: Domínguez-Roldan
authors.forename: M
authors.initials: M
authors.lastname: Manyalich
authors.forename: E
authors.initials: E
authors.lastname: Trias
authors.forename: D
authors.initials: D
authors.lastname: Paredes
authors.forename: A
authors.initials: A
authors.lastname: Navarro
authors.forename: J
authors.initials: J
authors.lastname: Nicolás
authors.forename: R
authors.initials: R
authors.lastname: Valero
authors.forename: C
authors.initials: C
authors.lastname: García
authors.forename: A
authors.initials: A
authors.lastname: Ruiz
authors.forename: A
authors.initials: A
authors.lastname: Vilarrodona
mesh_terms: D000328:Adult; D000368:Aged; D001926:Brain Death / Q000145:classification* / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003399:Craniotomy; D003971:Diastole / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012189:Retrospective Studies; D014019:Tissue Donors; D017585:Ultrasonography, Doppler, Transcranial / Q000379:methods*