title: Reverse remodeling of sinus node function after catheter ablation of atrial fibrillation in patients with prolonged sinus pauses.
abstract: BACKGROUND
  Symptomatic prolonged sinus pauses on termination of atrial fibrillation (AF) are an indication for pacemaker implantation. We evaluated sinus node function and clinical outcome in patients with prolonged sinus pauses on termination of arrhythmia who underwent ablation of paroxysmal AF.
  
  
  RESULTS
  Twenty patients with paroxysmal AF and prolonged sinus pauses (> or =3 seconds) on termination of AF underwent ablation between May 1995 and November 2002. Patients with sinus pauses independent of episodes of AF were excluded from the analysis. The procedure included pulmonary vein and linear atrial ablation. After ablation, sinus node function was assessed during the first week and at 1, 3, and 6 months, by 24-hour ambulatory monitoring to determine the mean heart rate and heart rate range, and by exercise testing to determine the maximal heart rate. Corrected sinus node recovery time was determined at the completion of ablation and at 24.0+/-11.3 months at 600 and 400 ms. After AF ablation, there was a significant improvement of sinus node function, with an increase in the mean heart rate (P=0.001), maximal heart rate (P<0.0001), and heart rate range (P<0.0001). The corrected sinus node recovery time decreased in all patients evaluated at 600 ms (P=0.016) and 400 ms (P=0.019). At 26.0+/-17.6 months, 18 patients (85%) had no recurrence of AF (in the absence of medication), with no symptoms attributable to bradycardia or sinus pauses on ambulatory monitoring. Two patients had infrequent episodes of AF, 1 requiring pacemaker implantation.
  
  
  CONCLUSIONS
  Prolonged sinus pauses after paroxysms of AF may result from depression of sinus node function that can be eliminated by curative ablation of AF. This is accompanied by improvement in parameters of sinus node function, suggesting reverse remodeling of the sinus node.
authors.affiliation: Hôpital Cardiologique du Haut-Lévêque, Avenue de Magellan, 33604, Bordeaux-Pessac, France.
authors.forename: Mélèze
authors.initials: M
authors.lastname: Hocini
authors.forename: Prashanthan
authors.initials: P
authors.lastname: Sanders
authors.forename: Isabel
authors.initials: I
authors.lastname: Deisenhofer
authors.forename: Pierre
authors.initials: P
authors.lastname: Jaïs
authors.forename: Li-Fern
authors.initials: LF
authors.lastname: Hsu
authors.forename: Christophe
authors.initials: C
authors.lastname: Scavée
authors.forename: Rukshen
authors.initials: R
authors.lastname: Weerasoriya
authors.forename: Florence
authors.initials: F
authors.lastname: Raybaud
authors.forename: Laurent
authors.initials: L
authors.lastname: Macle
authors.forename: Dipen C
authors.initials: DC
authors.lastname: Shah
authors.forename: Stéphane
authors.initials: S
authors.lastname: Garrigue
authors.forename: Philippe
authors.initials: P
authors.lastname: Le Metayer
authors.forename: Jacques
authors.initials: J
authors.lastname: Clémenty
authors.forename: Michel
authors.initials: M
authors.lastname: Haïssaguerre
mesh_terms: D001281:Atrial Fibrillation / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery*; D017115:Catheter Ablation; D004562:Electrocardiography; D022062:Electrophysiologic Techniques, Cardiac; D005080:Exercise Test; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D012849:Sinoatrial Node / Q000502:physiology / Q000503:physiopathology*; D016896:Treatment Outcome