Microtubule-stabilizing marine metabolite laulimalide and its derivatives: synthetic approaches and antitumor activity.
Mulzer
Johann
J
Institut für Organische Chemie der Universität Wien, Währinger Strasse 38, A-1090 Vienna, Austria. johan.mulzer@univie.ac.at
Ohler
Elisabeth
E
D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D018942:Macrolides; D008870:Microtubules / Q000187:drug effects; D010051:Ovarian Neoplasms / Q000188:drug therapy; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000633:toxicity; D043823:Taxoids
D000970:Antineoplastic Agents; D018942:Macrolides; D043823:Taxoids; C117305:laulimalide; D017239:Paclitaxel