Characterization of the transit and transition times for a pathway unit of Michaelis-Menten mechanism.
The transit time and a characteristic time constant for the transition time are formulated for a pathway unit of Michaelis-Menten mechanism in metabolic chains with mass-action-type dependence. The pathway unit in a chain is assigned to each metabolite and two consecutive Michaelis-Menten-type reactions associated with it. All the relevant functions such as control coefficients, elasticities and transit time for the pathway unit are expressed in terms of the flux J and other system parameters. The transition time is characterized by a time constant for a first-order system expressed as the derivative of the total concentration of the internal metabolite with respect to the flux J.
Sakamoto
Naoto
N
Faculty of Information Science, Kyushu Sangyo University, Fukuoka 813-8503, Japan. sakamoto@is.kyusan-u.ac.jp
de Atauri
Pedro
P
Cascante
Marta
M
D003198:Computer Simulation; D005246:Feedback; D016014:Linear Models; D008660:Metabolism / Q000502:physiology*; D008954:Models, Biological; D008956:Models, Chemical; D015398:Signal Transduction / Q000502:physiology*; D013997:Time Factors