title: Directly observed antiretroviral therapy to reduce genital tract and plasma HIV-1 RNA in women with poor adherence.
abstract: Six women with substance abuse and poor adherence histories received daily antiretroviral directly observed therapy (DOT). Cervicovaginal lavage (CVL) and plasma HIV-1-RNA levels were measured at baseline, 1 month, 3 months, and 6 months. All subjects had undetectable (below 2.6 log10 copies/ml) CVL HIV-1-RNA levels by 3 months and undetectable plasma HIV-1-RNA levels by 6 months. The mean CD4 cell increase was 76 cells/mm3. DOT appears effective and may reduce infectiousness in this high-risk population.
authors.affiliation: Brown University, Providence, RI, USA.
authors.forename: Joseph I
authors.initials: JI
authors.lastname: Harwell
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Flanigan
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Mitty
authors.forename: Grace E
authors.initials: GE
authors.lastname: Macalino
authors.forename: Angela M
authors.initials: AM
authors.lastname: Caliendo
authors.forename: Jessica
authors.initials: J
authors.lastname: Ingersoll
authors.forename: Molly S
authors.initials: MS
authors.lastname: Stenzel
authors.forename: Charles C J
authors.initials: CC
authors.lastname: Carpenter
authors.forename: Susan
authors.initials: S
authors.lastname: Cu-Uvin
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023801:Directly Observed Therapy; D005260:Female; D005500:Follow-Up Studies; D005836:Genitalia, Female / Q000821:virology*; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D010349:Patient Compliance; D012367:RNA, Viral / Q000097:blood
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral