title: Neurological signs and results of magnetic resonance imaging in 40 cavalier King Charles spaniels with Chiari type 1-like malformations.
abstract: In human beings a Chiari type 1 malformation is a developmental condition characterised by cerebellar herniation and syringohydromyelia. Abnormalities compatible with such a malformation were identified by magnetic resonance imaging in 39 cavalier King Charles spaniels with neurological signs and in one neurologically normal cavalier King Charles spaniel that was examined postmortem. The dogs with these abnormalities had a wide variety of neurological signs, but there was no apparent correlation between the neurological signs and the severity of cerebellar herniation, syringohydromyelia or hydrocephalus.
authors.affiliation: Department of Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hertfordshire AL9 7TA.
authors.forename: D
authors.initials: D
authors.lastname: Lu
authors.forename: C R
authors.initials: CR
authors.lastname: Lamb
authors.forename: D U
authors.initials: DU
authors.lastname: Pfeiffer
authors.forename: M P
authors.initials: MP
authors.lastname: Targett
mesh_terms: D000818:Animals; D002526:Cerebellar Diseases / Q000503:physiopathology / Q000662:veterinary*; D002531:Cerebellum / Q000002:abnormalities*; D004283:Dog Diseases / Q000503:physiopathology*; D004285:Dogs; D005260:Female; D008279:Magnetic Resonance Imaging; D008297:Male