title: Effects of hypothermia on mortality and inflammatory responses to endotoxin-induced shock in rats.
abstract: We studied the effects of hypothermia on mortality rate, concentrations of tumor necrosis factor alpha and interleukin 6 in plasma, and the end products of nitric oxide (NO) in endotoxemia. It was found that moderate and mild hypothermia improved the mortality rate and attenuated cytokine responses and the elevation of the end products of NO after endotoxin injection and that these beneficial effects were similar for moderate and mild hypothermia.
authors.affiliation: Department of Emergency and Critical Care Medicine, Graduate School of Medical Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8641, Japan. taniyan@med.kanazawa-u.ac.jp
authors.forename: Takumi
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kanakura
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takemoto
authors.forename: Ken
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D004731:Endotoxins / Q000009:adverse effects*; D007036:Hypothermia, Induced; D007249:Inflammation / Q000378:metabolism* / Q000628:therapy; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D009569:Nitric Oxide / Q000097:blood / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012772:Shock, Septic / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D004731:Endotoxins; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; C044101:endotoxin, Escherichia coli