title: Tyrosinase inhibitory prenylated flavonoids from Sophora flavescens.
abstract: For the purpose of the development of a skin-whitening agent, Sophora flavescens was evaluated for tyrosinase inhibitory activity and its active principles were identified following activity-guided isolation. The ethanol extract and dichloromethane fraction from S. flavescens showed significant inhibition of mushroom tyrosinase. From the dichloromethane fraction, three known prenylated flavonoids, sophoraflavanone G, kuraridin, and kurarinone, were isolated. Compared with kojic acid (IC(50)=20.5 microM), these compounds possessed more potent tyrosinase inhibitory activity. The IC(50) values were 6.6, 0.6, and 6.2 microM for sophoraflavanone G, kuraridin, and kurarinone, respectively.
authors.affiliation: College of Pharmacy, Kangwon National University, Chunchon, Korea.
authors.forename: Soo Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Kun Ho
authors.initials: KH
authors.lastname: Son
authors.forename: Hyun Wook
authors.initials: HW
authors.lastname: Chang
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
authors.forename: Hyun Pyo
authors.initials: HP
authors.lastname: Kim
mesh_terms: D000363:Agaricales / Q000201:enzymology; D004791:Enzyme Inhibitors; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D007723:Korea; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D018517:Plant Roots / Q000737:chemistry; D029909:Sophora / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D005419:Flavonoids; D014442:Monophenol Monooxygenase