Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice.
The anti-seizure effect of oleamide, an endogenous sleep-inducing fatty acid amide, was studied in mice. Oleamide, in the dose range 43.7-700.0 mg kg(-1), significantly and dose-dependently inhibited the seizures induced by pentylenetetrazole. However, oleamide showed no inhibitory action on the seizures induced by picrotoxin, strychnine, caffeine or semicarbazide. These results provide the first evidence for the anti-seizure effect of oleamide, and suggest that this effect may be selective to the seizure model induced by pentylenetetrazole.
Wu
Chun-Fu
CF
Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China. wuchunf@21cn.com
Li
Chun-Li
CL
Song
Hong-Rui
HR
Zhang
Hua-Feng
HF
Yang
Jing-Yu
JY
Wang
Yu-Ling
YL
D000818:Animals; D003292:Convulsants / Q000009:adverse effects*; D003975:Diazepam / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009829:Oleic Acids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D010433:Pentylenetetrazole / Q000009:adverse effects*; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control*; D012890:Sleep / Q000187:drug effects / Q000502:physiology
D003292:Convulsants; D009829:Oleic Acids; C029407:oleylamide; D003975:Diazepam; D010433:Pentylenetetrazole