Decreasing sensitivity to RANTES (regulated on activation, normally T cell-expressed and -secreted) neutralization of CC chemokine receptor 5-using, non-syncytium-inducing virus variants in the course of human immunodeficiency virus type 1 infection.
In approximately half of human immunodeficiency virus (HIV) type 1-infected individuals, the development of CXC chemokine receptor 4-using, syncytium-inducing (SI) virus variants precedes a rapid progression to acquired immunodeficiency syndrome (AIDS). In other individuals, only CC chemokine receptor 5-using (R5), non-SI (NSI) virus variants are present throughout infection. These individuals may be either long-term survivors (LTSs) or rapid progressors. The basis for this variable disease progression in individuals with only R5 virus variants is not yet fully understood. In this study, the beta-chemokine sensitivity of biological HIV-1 clones isolated from 13 individuals who harbored only R5, NSI virus variants (7 LTSs and 6 progressors) was investigated. We found a statistically significant decrease in sensitivity of virus variants to RANTES (regulated on activation, normally T cell-expressed and -secreted) neutralization during the course of progressive infection, but not during follow-up of LTSs. Our data suggest that a role exists for RANTES neutralization sensitivity of HIV-1 in AIDS pathogenesis.
Koning
Fransje A
FA
Department of Clinical Viro Immunology, Sanquin Research at CLB, Amsterdam, The Netherlands.
Kwa
David
D
Boeser-Nunnink
Brigitte
B
Dekker
Jos
J
Vingerhoed
Jose
J
Hiemstra
Harry
H
Schuitemaker
Hanneke
H
D018946:Chemokine CCL5 / Q000276:immunology*; D018450:Disease Progression; D014644:Genetic Variation; D005838:Genotype; D015726:Giant Cells / Q000502:physiology; D015658:HIV Infections / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D020276:HIV Long-Term Survivors; D015497:HIV-1 / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D009500:Neutralization Tests; D019713:Receptors, CCR5 / Q000378:metabolism*
D018946:Chemokine CCL5; D019713:Receptors, CCR5