Dendritic cells in peripheral tolerance and immunity.
Dendritic cells capable of influencing immunity exist as functionally distinct subsets, T cell-tolerizing and T cell-immunizing subsets. The present paper reviews how these subsets of DCs develop, differentiate and function in vivo and in vitro at the cellular and molecular level. In particular, the role of DCs in the generation of regulatory T cells is highlighted.
Gad
Monika
M
Department of Medical Anatomy, The Panum Institute, University of Copenhagen, Copenhagen, Denmark.
Claesson
Mogens Helweg
MH
Pedersen
Anders Elm
AE
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007111:Immunity, Cellular / Q000276:immunology; D016131:Lymphocyte Subsets; D051379:Mice