Chronic, multisite, multielectrode recordings in macaque monkeys.
A paradigm is described for recording the activity of single cortical neurons from awake, behaving macaque monkeys. Its unique features include high-density microwire arrays and multichannel instrumentation. Three adult rhesus monkeys received microwire array implants, totaling 96-704 microwires per subject, in up to five cortical areas, sometimes bilaterally. Recordings 3-4 weeks after implantation yielded 421 single neurons with a mean peak-to-peak voltage of 115 +/- 3 microV and a signal-to-noise ratio of better than 5:1. As many as 247 cortical neurons were recorded in one session, and at least 58 neurons were isolated from one subject 18 months after implantation. This method should benefit neurophysiological investigation of learning, perception, and sensorimotor integration in primates and the development of neuroprosthetic devices.
Nicolelis
Miguel A L
MA
Department of Neurobiology, Duke University, Durham, NC 27710, USA. nicoleli@neuro.duke.edu
Dimitrov
Dragan
D
Carmena
Jose M
JM
Crist
Roy
R
Lehew
Gary
G
Kralik
Jerald D
JD
Wise
Steven P
SP
D000200:Action Potentials; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D004566:Electrodes; D005260:Female; D008253:Macaca mulatta; D008297:Male