Delta-F508 cystic fibrosis mutation is not linked to intussusception: implications for rotavirus vaccine.
OBJECTIVE
To determine whether the cystic fibrosis (CF) delta-F508 gene mutation predisposes to intussusception, and so selects infants who should not receive rotavirus vaccine.


METHODS
Stored neonatal screening blood spots, retrieved from 81 infants with intussusception and from 79 controls, were tested for the presence of the CF delta-F508 gene mutation.


RESULTS
Prevalence of the mutation was similar in blood specimens from intussusception patients and from controls.


CONCLUSIONS
Testing for the CF delta-F508 mutation at birth is unlikely to identify infants predisposed to intussusception, and therefore is not relevant to rotavirus vaccine programs.
Barnes
G
G
The Murdoch Childrens Research Institute, University of Melbourne, Royal Children's Hospital, Parkville, Australia. graeme.barnes@rch.org.au
Srivastava
A
A
Carlin
J
J
Francis
I
I
D001315:Australia; D003550:Cystic Fibrosis / Q000097:blood / Q000235:genetics*; D006580:Genetic Carrier Screening; D006801:Humans; D007231:Infant, Newborn; D007443:Intussusception / Q000097:blood / Q000209:etiology*; D009154:Mutation; D015997:Neonatal Screening; D016017:Odds Ratio; D022243:Rotavirus Vaccines / Q000008:administration & dosage*
D022243:Rotavirus Vaccines