Lipoteichoic acid and peptidoglycan from Staphylococcus aureus synergistically induce neutrophil influx into the lungs of mice.
Staphylococcus aureus is an important pathogen in nosocomial pneumonia. Lipoteichoic acid (LTA) and peptidoglycan (PepG) are part of the staphylococcal cell wall. Here we show that LTA and PepG act in synergy to cause polymorphonuclear cell recruitment in the pulmonary compartment during S. aureus pneumonia.
Leemans
Jaklien C
JC
Laboratory of Experimental Internal Medicine, Utrecht University, Utrecht, The Netherlands. j.c.leemans@amc.uva.nl
Heikens
Mirjam
M
van Kessel
Kok P M
KP
Florquin
Sandrine
S
van der Poll
Tom
T
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology* / Q000494:pharmacology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology; D002465:Cell Movement; D004195:Disease Models, Animal; D004357:Drug Synergism; D004797:Enzyme-Linked Immunosorbent Assay; D007150:Immunohistochemistry; D008070:Lipopolysaccharides / Q000276:immunology* / Q000494:pharmacology; D008168:Lung / Q000276:immunology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000276:immunology*; D010457:Peptidoglycan / Q000276:immunology* / Q000494:pharmacology; D011023:Pneumonia, Staphylococcal / Q000276:immunology* / Q000473:pathology; D013211:Staphylococcus aureus / Q000276:immunology; D013682:Teichoic Acids / Q000276:immunology* / Q000494:pharmacology
D000942:Antigens, Bacterial; D008070:Lipopolysaccharides; D010457:Peptidoglycan; D013682:Teichoic Acids; C009900:lipoteichoic acid