title: Effects of exhaustive incremental treadmill exercise on diaphragm and quadriceps motor potentials evoked by transcranial magnetic stimulation.
abstract: It is unknown whether changes in corticomotor excitability follow exercise in healthy humans. We hypothesized that a fall in the diaphragm and quadriceps motor-evoked potential (MEP) amplitude elicited by transcranial magnetic stimulation of the motor cortex would occur after an incremental exercise task. In 11 healthy subjects, we measured transdiaphragmatic pressure and isometric quadriceps tension in response to supramaximal peripheral magnetic nerve stimulation. MEPs were recorded from these muscles in response to transcranial magnetic stimulation. After baseline measurements, subjects performed a period of submaximal exercise (gentle walking). Measurements were repeated 5 and 20 min after this. The subjects then exercised on a treadmill with an incremental protocol to exhaustion. Transcranial magnetic stimulation was performed at baseline and at 5, 20, 40, and 60 min after exhaustive exercise, and force measurements were obtained at baseline, 20 min, and 60 min. Mean exercise duration was 18 +/- 4 min, and mean maximum heart rate was 172 +/- 10 beats/min. Twitch transdiaphragmatic pressure and twitch isometric quadriceps tension were not different from baseline after exercise, but a significant decrease was observed in diaphragm MEP amplitude 5 and 20 min after exercise (60 +/- 38 and 45 +/- 24%, respectively, of baseline, P = 0.0001). At the same times, the mean quadriceps MEPs were 59 +/- 39 and 74 +/- 32% of baseline (P < 0.0001 and P < 0.01, respectively). Studies using paired stimuli confirmed a likely intracortical mechanism for this depression. Our data confirm significant depression of both diaphragm and quadriceps MEPs after incremental treadmill exercise.
authors.affiliation: Laboratoire de Physiopathologie Respiratoire et Unité de Réanimation, Service de Pneumologie, Groupe Hospitalier Pitié-Slapêtriète, Assistance Publique-Hôspitaux de paris, 75013 Paris, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Verin
authors.forename: Ewen
authors.initials: E
authors.lastname: Ross
authors.forename: Alexandre
authors.initials: A
authors.lastname: Demoule
authors.forename: Nicholas
authors.initials: N
authors.lastname: Hopkinson
authors.forename: Annabel
authors.initials: A
authors.lastname: Nickol
authors.forename: Brigitte
authors.initials: B
authors.lastname: Fauroux
authors.forename: John
authors.initials: J
authors.lastname: Moxham
authors.forename: Thomas
authors.initials: T
authors.lastname: Similowski
authors.forename: Michael I
authors.initials: MI
authors.lastname: Polkey
mesh_terms: D000328:Adult; D003964:Diaphragm / Q000294:innervation / Q000502:physiology*; D004558:Electric Stimulation; D004566:Electrodes; D004947:Esophagus; D019054:Evoked Potentials, Motor / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D009046:Motor Neurons / Q000502:physiology; D018763:Muscle Fatigue / Q000502:physiology*; D013848:Thigh; D050781:Transcranial Magnetic Stimulation