title: Glycidol-carbohydrate hybrids: a new family of DNA alkylating agents.
abstract: Novel and chiral glycidol-carbohydrate hybrids possessing an epoxy group as a DNA alkylating moiety were designed and synthesized. These artificial hybrids selectively alkylated DNA at the N-7 sites of the guanines and cleaved DNA without any additives. The binding ability of the glycidol was significantly enhanced by the attachment of the carbohydrate.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan. toshima@applc.keio.ac.jp
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Toshima
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Okuno
authors.forename: Shuichi
authors.initials: S
authors.lastname: Matsumura
mesh_terms: D000477:Alkylating Agents / Q000737:chemistry* / Q000378:metabolism*; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry; D004247:DNA / Q000378:metabolism*; D004852:Epoxy Compounds / Q000737:chemistry* / Q000378:metabolism*; D020005:Propanols / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D000477:Alkylating Agents; D002241:Carbohydrates; D004852:Epoxy Compounds; D020005:Propanols; D004247:DNA; C004312:glycidol