[FTIR spectroscopic study of normal and malignant tissues of rectum].
Fourier transform infrared (FTIR) spectroscopy was used to study the normal and malignant tissues of rectum. The FTIR spectra of tissues were measured by Nicolet Magna IR-750 spectrometer equipped with mid-infrared fiber optics. The results show that the intensity ratios of five pairs of bands can be used to distinguish the normal and malignant tissues. In the spectra of malignant tissues the relative intensities ratios of I2,873/I2,852 and I1,312/I1,245 were higher than those of normal ones; however, the ratios of I1,745/I1,643, I1,458/I1,400 and I1,162/I1,082 were lower. These results, proved by data-analysis of spectra from 21 patients, were generally shown in the spectra of rectum tissues. The study of near-malignant tissues (one centimeter beside the malignant point) of rectum by FTIR shows that these ratios of bands were in a transient state between normal and malignant rectum tissues.
Wang
Fan
F
College of Chemistry and Molecular Engineering, Department of Chemical Biology, Peking University, Beijing 100871, China.
Ling
Xiao-feng
XF
Yang
Zhan-lan
ZL
Xu
Zhi
Z
Ren
Yu
Y
Li
Wei-hong
WH
Weng
Shi-fu
SF
Wu
Jin-guang
JG
D006801:Humans; D012004:Rectal Neoplasms / Q000737:chemistry*; D012007:Rectum / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared