[Effect of deafferentation on the size and myosin phenotype of muscle fibers during stretching of rat m. soleus and gravitational unloading].
The study was purposed to evaluate the contribution of the reflectory and local components during the chronic stretch of the postural muscle to the attenuation of the unloading-induced fiber size reduction and changes in the myosin heavy chain (MHC) profile. The surgical unilateral deafferentation (dorsal rhizotomy) was used. It was shown that unilateral deafferentation didn't influence on the amelioration of unloading-induced fiber size reduction in chronically stretched soleus muscle. Thus, the results obtained in the present study don't confirm the hypothesis, supposing the predominant contribution of the muscle afferent activation to the attenuation of unloading-induced fiber atrophy. Deafferentation of unloaded as well as control rats leads to the increase of the percentage of fibers expressing slow MYC isoforms.
Nemirovskaia
T L
TL
Institute of Medical-Biological Problems, Russian Acad. Sci., Russia, 123007, Moscow, 76a Khoroshevskoe Shosse.
Shenkman
B S
BS
Mukhina
A M
AM
Volodkovich
Ia Iu
IaIu
Saiapina
M M
MM
Brattseva
E V
EV
Larina
O M
OM
D000818:Animals; D019417:Hindlimb Suspension; D008297:Male; D009121:Muscle Denervation; D018485:Muscle Fibers, Skeletal / Q000378:metabolism / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation / Q000378:metabolism / Q000502:physiology*; D018995:Myosin Heavy Chains / Q000096:biosynthesis*; D010641:Phenotype; D051381:Rats; D017208:Rats, Wistar; D018474:Weightlessness Simulation
D018995:Myosin Heavy Chains
Vliianie deafferentatsii na razmery i miozinovyĭ fenotip myshechnykh volokon pri rastiazhenii m.soleus krysy na fone gravitatsionnoĭ razgruzki.