title: Does recurrent sinusitis lead to a sinusitis remodeling of the upper airways in asthmatic children with chronic rhinitis?
abstract: BACKGROUND
  There is a growing recognition that some patients with long-standing asthma may possess a component of irreversible airflow obstruction due to airway remodeling. The underlying chronic inflammation has been implicated as the cause of this process. In the upper airways, the inflammation presents itself with symptoms of chronic rhinitis, leading to recurrent sinusitis, in some patients.
  
  
  OBJECTIVE
  We attempted to determine if any changes that might be considered remodeling had occurred in the nasopharynx and paranasal sinuses of asthmatic children with recurrent sinusitis.
  
  
  METHODS
  Computerized-tomography (CT) scanning of the nasopharynx and paranasal sinuses was investigated retrospectively.
  
  
  RESULTS
  Sixty-six asthmatic patients with chronic rhinitis and recurrent sinusitis were analyzed in this respect. Their mean age was 7.41 +/- 2.91 years (26 female, 39 male). In 89% (n = 59) of the patients, tomography findings were abnormal. Among these subjects, sinusal-mucosal thickening was present in 75% (n = 44), and concha hypertrophy was present in 51% (n = 30). Adenoid hypertrophy was present in 20% (n = 12), and septum deviation was present in 17% (n = 10). CT findings were normal in 11% (n = 7).
  
  
  CONCLUSIONS
  In most of the asthmatic children having chronic rhinitis and recurrent sinusitis, the upper respiratory tract underwent a series of changes, which might be assessed as remodeling. Thus, tomography of the upper-respiratory tract may provide some useful information about the state of the disease, and to what extent the treatment can relieve symptoms of the sinus disease and the concomitant asthma.
authors.affiliation: SSK Goztepe Training and Research Hospital, Department of Pediatric Allergy, Istanbul, Turkey. ynuhoglu@hotmail.com
authors.forename: Yonca
authors.initials: Y
authors.lastname: Nuhoglu
authors.forename: Cagatay
authors.initials: C
authors.lastname: Nuhoglu
authors.forename: Elif
authors.initials: E
authors.lastname: Sirlioglu
authors.forename: Sevil
authors.initials: S
authors.lastname: Ozcay
mesh_terms: D001249:Asthma / Q000150:complications* / Q000000981:diagnostic imaging; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D009305:Nasopharynx / Q000000981:diagnostic imaging*; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging*; D012008:Recurrence; D012189:Retrospective Studies; D012220:Rhinitis / Q000150:complications* / Q000000981:diagnostic imaging; D012852:Sinusitis / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed