[Genes related to phospholipid metabolism as risk factors related to bipolar affective disorder].
The studies of genetic epidemiology provides consistent evidence of genetic factors having a major role on the risk for the bipolar affective disorder, although, vulnerability genes have not yet been identified in unequivocal form. The authors show that phospholipids play an important role in the cellular signalling processes, besides this, some studies with mood-stabilisers neurochemistry suggest that these drugs act in the phospholipase regulated signalling views. They conclude that analysis of gene variants that code enzymes of the phospholipids metabolism as potential susceptibility genes can extend the knowledge concerning the risk factors and the physiopatological mechanisms underling this mood disturbance.
Meira-Lima
Ivanor V
IV
Laboratório de Neurociências. Instituto de Psiquiatria Faculdade de Medicina da Universidade de São Paulo. São Paulo, SP, Brasil.
Vallada
Homero
H
D001714:Bipolar Disorder / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D010743:Phospholipids / Q000235:genetics* / Q000378:metabolism*; D012307:Risk Factors
D010743:Phospholipids
Genes relacionados ao metabolismo dos fosfolípides como fatores de risco para o transtorno afetivo bipolar.