CCK-nitric oxide interaction in rat cortex, striatum and pallidum.
We have chosen to study the effects of both nitric oxide (NO) and cholecystokinin neuromodulatory systems in some motor structures that are frequently involved in excitotoxic phenomena. In particular, 7-nitroindazole, a selective inhibitor of neuronal NO synthase, was administered in control and sulfated cholecystokinin octapeptide-treated rats. Cortical surface, striatal and pallidal depth bioelectric activities were examined through Fast Fourier Transform analysis. Cortical and pallidal recordings revealed an increase of rapid standard rhythms after the inhibition of neuronal NO synthase; in contrast, striatal depth recordings showed a marked increase of slow standard rhythms. All these effects were completely abolished by chronic pre-treatment with sulfated cholecystokinin octapeptide. The results suggest a functional co-operation between cholecystokinin and NO systems in the modulation of the bioelectric activity of all the motor structures examined, and the possibility of preventing excitotoxic damages induced by an anomalous balance between excitatory and inhibitory neurotransmitters in these areas.
Ferraro
Giuseppe
G
Department of Experimental Medicine, Human Physiology Section G. Pagano--Corso Tuköry, 129, I-90134 Palermo, Italy.
Sardo
Pierangelo
P
Di Giovanni
Giuseppe
G
Di Maio
Roberto
R
La Grutta
Vittorio
V
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism* / Q000502:physiology; D003342:Corpus Striatum / Q000378:metabolism* / Q000502:physiology; D004569:Electroencephalography; D005917:Globus Pallidus / Q000378:metabolism* / Q000502:physiology; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012844:Sincalide / Q000031:analogs & derivatives / Q000378:metabolism* / Q000494:pharmacology
D009569:Nitric Oxide; D012844:Sincalide