title: Array painting: a method for the rapid analysis of aberrant chromosomes using DNA microarrays.
abstract: OBJECTIVE
  The authors describe a method, termed array painting, which allows the rapid, high resolution analysis of the content and breakpoints of aberrant chromosomes.
  
  
  METHODS
  Array painting is similar in concept to reverse chromosome painting and involves the hybridisation of probes generated by PCR of small numbers of flow sorted chromosomes on large insert genomic clone DNA microarrays.
  
  
  RESULTS
  and
  
  
  CONCLUSIONS
  By analysing patients with cytogenetically balanced chromosome rearrangements, the authors show the effectiveness of array painting as a method to map breakpoints prior to cloning and sequencing chromosome rearrangements.
authors.affiliation: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
authors.forename: H
authors.initials: H
authors.lastname: Fiegler
authors.forename: S M
authors.initials: SM
authors.lastname: Gribble
authors.forename: D C
authors.initials: DC
authors.lastname: Burford
authors.forename: P
authors.initials: P
authors.lastname: Carr
authors.forename: E
authors.initials: E
authors.lastname: Prigmore
authors.forename: K M
authors.initials: KM
authors.lastname: Porter
authors.forename: S
authors.initials: S
authors.lastname: Clegg
authors.forename: J A
authors.initials: JA
authors.lastname: Crolla
authors.forename: N R
authors.initials: NR
authors.lastname: Dennis
authors.forename: P
authors.initials: P
authors.lastname: Jacobs
authors.forename: N P
authors.initials: NP
authors.lastname: Carter
mesh_terms: D000328:Adult; D002460:Cell Line; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D025063:Chromosome Disorders / Q000235:genetics / Q000473:pathology; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D007621:Karyotyping / Q000379:methods; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D014178:Translocation, Genetic