[Mechanisms and role of lymphangiogenesis in cancer metastasis].
An important critical point in tumor progression is the acquisition of metastatic potential. The presence of metastases in regional lymph nodes is an indicator of poor survival. The vascular endothelial growth factor (VEGF) family of growth factors and receptors is involved in vasculogenesis and angiogenesis. Among them, VEGF-C and VEGF-D regulate the lymphatic vessels development and growth via their binding to their receptor VEGFR3. The expression of VEGF-C or VEGF-D is demonstrated in various human tumors and can be used as pronostic factors in some of them. With the aid of these molecules and the discovery of specific lymphatic markers, lymphatic endothelial cells can be isolated and lymphatic vessels can be identified within tumors. The role of lymphangiogenesis in promoting the metastatic spread of tumor cells has been studied in animal models.
Dupuy
Evelyne
E
Institut des vaisseaux et du sang, hôpital Lariboisière, 2 rue Ambroise-Paré, 75010, Paris, France. evelyne.dupuy@alrb.ap-hop-paris.fr
Tobelem
Gérard
G
D018929:Cell Culture Techniques / Q000379:methods; D016228:Endothelial Growth Factors / Q000235:genetics / Q000502:physiology*; D006133:Growth Substances / Q000502:physiology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000502:physiology*; D008198:Lymph Nodes / Q000254:growth & development*; D008207:Lymphatic Metastasis / Q000503:physiopathology*; D008222:Lymphokines / Q000235:genetics / Q000502:physiology*; D009154:Mutation; D014407:Tumor Cells, Cultured; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
Mécanisme de la lymphangiogenèse tumorale, longtemps oubliée, dans la dissémination métastatique.