Arginine-based molecular transporters: the synthesis and chemical evaluation of releasable taxol-transporter conjugates.
[structure: see text] A flexible and efficient procedure has been developed for the conjugation of taxol to various arginine-based molecular transporters via the taxol C2' O-chloroacetyl derivative. The resultant taxol-transporter conjugates are highly water soluble and release free taxol with half-lives of minutes to hours depending on the pH and the linker structure.
Kirschberg
Thorsten A
TA
CellGate, Inc., 552 Del Rey Avenue, Sunnyvale, California 95085, USA. kirschberg@cellgateinc.com
VanDeusen
Chris L
CL
Rothbard
Jonathan B
JB
Yang
Michael
M
Wender
Paul A
PA
D000107:Acetylation; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001120:Arginine / Q000031:analogs & derivatives*; D006207:Half-Life; D006863:Hydrogen-Ion Concentration; D026901:Membrane Transport Proteins / Q000138:chemical synthesis*; D015394:Molecular Structure; D017239:Paclitaxel / Q000737:chemistry*; D012995:Solubility; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D026901:Membrane Transport Proteins; D001120:Arginine; D017239:Paclitaxel