Association study between late-onset Alzheimer's disease and the transferrin gene polymorphisms in Chinese.
To investigate the possible involvement of the transferrin (TF) gene polymorphism in the manifestation of Alzheimer's disease (AD), we analyzed the TF and apolipoprotein E (APOE) genotypes of 67 sporadic late-onset AD patients and 131 normal elderly controls in the Chinese population. Our data showed that the TF C1 homozygosity carriers had an increased risk of AD in subjects > or =75 years of age, showing that homozygosity for the TF C1 allele was associated with an approximately three-fold increased risk (OR=3.57, 95% CI, 1.24-10.27, P=0.014). No synergic effects were found between the APOE epsilon 4 allele and TF gene polymorphisms.
Zhang
Peng
P
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, 100101 Beijing, China.
Yang
Ze
Z
Zhang
Chuanfang
C
Lu
Zeping
Z
Shi
Xiaohong
X
Zheng
Weidong
W
Wan
Chunling
C
Zhang
Duanyang
D
Zheng
Chenguang
C
Li
Shu
S
Jin
Feng
F
Wang
Li
L
D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D001923:Brain Chemistry / Q000235:genetics*; D002681:China / Q000208:ethnology; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors; D014168:Transferrin / Q000235:genetics*
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D014168:Transferrin