title: Anorganic porous bovine-derived bone mineral (Bio-Oss) and ePTFE membrane in the treatment of peri-implantitis in cynomolgus monkeys.
abstract: The purpose of the present study was to evaluate the effect of anorganic porous bovine-derived bone mineral (Bio-Oss) and expanded polytetrafluoroethylene (ePTFE) membrane in the treatment of peri-implantitis. A total of 64 implants with a titanium plasma-sprayed (TPS) surface was inserted in eight cynomolgus monkeys (Macaca fascicularis). After a 3-month healing period with plaque control, experimental peri-implantitis characterized by a bone loss of 4-6 mm was induced during a period of 9-18 months. Surgical treatment involving Bio-Oss+membrane, Bio-Oss, membrane, or a conventional flap procedure (control) only was carried out. The animals were sacrificed six months after treatment. Evaluation by clinical parameters, radiography including quantitative digital subtraction radiography, histology, and stereology demonstrated healthy peri-implant tissue irrespective of the applied surgical procedure. However, the amount of re-osseointegration and the total amount of bone (Bio-Oss and regenerated bone) were significantly higher in defects treated with membrane-covered Bio-Oss as compared with the other three treatment procedures. A mean bone-to-implant contact of 36% was obtained within defects treated with membrane-covered Bio-Oss. The corresponding values for the three other treatment procedures were 13-23%. The Bio-Oss particles were in general highly integrated within the regenerated bone, but the particles in the occlusal part of the defects were entirely surrounded by connective tissue irrespective of membrane coverage. The present study demonstrates that surgical treatment involving Bio-Oss covered by an ePTFE membrane is a useful treatment modality of experimental peri-implantitis around implants with a TPS surface in cynomolgus monkeys. However, the treatment outcome is not as encouraging as seen with membrane-covered autogenous bone graft particles documented in a study with same experimental design.
authors.affiliation: Departments of Oral and Maxillofacial Surgery, School of Dentistry, University of Copenhagen and University Hospital (Rigshospitalet), Institute of Experimental Clinical Research, University of Aarhus, Aarhus, Denmark. ss@aas.nja.dk
authors.forename: Søren
authors.initials: S
authors.lastname: Schou
authors.forename: Palle
authors.initials: P
authors.lastname: Holmstrup
authors.forename: Torben
authors.initials: T
authors.lastname: Jørgensen
authors.forename: Lene Theil
authors.initials: LT
authors.lastname: Skovgaard
authors.forename: Kaj
authors.initials: K
authors.lastname: Stoltze
authors.forename: Erik
authors.initials: E
authors.lastname: Hjørting-Hansen
authors.forename: Ann
authors.initials: A
authors.lastname: Wenzel
mesh_terms: D016301:Alveolar Bone Loss / Q000601:surgery; D000539:Alveolar Process / Q000000981:diagnostic imaging; D000818:Animals; D001857:Bone Matrix / Q000637:transplantation; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000494:pharmacology*; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D020007:Implants, Experimental; D008252:Macaca fascicularis; D008297:Male; D008567:Membranes, Artificial; D008903:Minerals / Q000494:pharmacology; D010512:Periodontal Index; D010518:Periodontitis / Q000601:surgery*; D011138:Polytetrafluoroethylene; D016459:Prosthesis-Related Infections / Q000601:surgery*; D011859:Radiography; D013382:Subtraction Technique
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D015921:Dental Implants; D008567:Membranes, Artificial; D008903:Minerals; D011138:Polytetrafluoroethylene