Safety and efficacy of tacrolimus rescue therapy in 55 kidney transplant patients treated with cyclosporine.
To evaluate the efficacy and safety of conversion from cyclosporine to tacrolimus, we analyzed 55 kidney transplant patients who were converted due to cosmetic reasons in 42 patients, acute rejection in 2 patients, and other causes in 11 patients. At the doses and levels used, the development of diabetes mellitus was minimized. Disappearance of cosmetic side-effects and improvement of cardiovascular risk factors, together with conservation of renal function, encourage us to use tacrolimus as an efficacious and safe immunosuppressive therapy.
Urbizu
J M
JM
Nephrology Service, Hospital de Cruces, Baracaldo, Bizkaia, Spain.
Zárraga
S
S
Gómez-Ullate
P
P
Amenábar
J J
JJ
Gaínza
F I
FI
Lampreabe
I
I
Virto
J
J
Orbe
J
J
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D012189:Retrospective Studies; D012449:Safety; D016559:Tacrolimus / Q000627:therapeutic use*; D013997:Time Factors; D014527:Uric Acid / Q000097:blood
D001786:Blood Glucose; D007166:Immunosuppressive Agents; D014527:Uric Acid; D016572:Cyclosporine; D002784:Cholesterol; D016559:Tacrolimus