title: A tripeptidyl ensemble perspective of interactive control of growth hormone secretion.
abstract: Current investigational tools in molecular biology, biochemistry and integrative physiology have revealed an increasing array of signals that influence growth hormone (GH) secretion. The present perspective combines these factors under a simplified final-common pathway model of threefold joint control by GH-releasing hormone, GH-releasing peptide/ghrelin and somatostatin. This concept is highlighted from the viewpoint of sex steroid- and age-dependent modulation of the peptide trilogy listed above.
authors.affiliation: Mayo Medical and Graduate School of Medicine, Mayo Clinic, Rochester, MN 55905, USA. veldhuis.johannes@mayo.edu
authors.forename: Johannes D
authors.initials: JD
authors.lastname: Veldhuis
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D001066:Appetite / Q000187:drug effects; D025461:Feedback, Physiological; D054439:Ghrelin; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology / Q000502:physiology*; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D036361:Peptide Hormones / Q000502:physiology*; D013004:Somatostatin / Q000502:physiology*
chemical_list: D054439:Ghrelin; D036361:Peptide Hormones; D019382:Human Growth Hormone; D013004:Somatostatin; D013007:Growth Hormone-Releasing Hormone