Peptide inhibitors of plasmin.
Seven peptides of the general formula A-Phe-Lys-X or A-Phe-NH-(CH2)5-NH2 where A = Glp or Ala, X = -OH, -NHC7H15 or -OC7H15 were obtained. The peptide H-Ala-Phe-Lys-NHC7H15 markedly inhibits the fibrinolytic activity of plasmin. The antifibrinolytic activity of the peptide Glp-Phe-Lys-OC7H15 is similar to EACA. The both peptides only slightly activate the caseinolytic activity of plasmin.
Midura-Nowaczek
K
K
Institute of Chemistry, Branch of Warsaw University, Białystok.
Bruzgo
I
I
Roszkowska-Jakimiec
W
W
Worowski
K
K
D002364:Caseins / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D005341:Fibrinolysin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006868:Hydrolysis; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology*
D002364:Caseins; D005343:Fibrinolytic Agents; D010455:Peptides; D005341:Fibrinolysin