Trends in cancer therapy: role of monoclonal antibodies.
OBJECTIVE
To discuss the scientific rationale for the use of monoclonal antibodies in cancer treatment and distinguish the unique characteristics of selected monoclonal antibodies.


METHODS
Published scientific papers, abstracts, review articles, and book chapters.


CONCLUSIONS
The continued discovery of intrinsic antigens/epitopes specific to malignant cells and the science of immune cell activation demonstrates the durability of monoclonal antibodies as mainstream immunotherapy.


CONCLUSIONS
With the success of monoclonal antibodies used in clinical practice, oncology nurses need to continue to increase their knowledge and competency. Monoclonal antibodies target tumor-associated antigens in both solid and hematologic tumors. It is imperative that nurses be familiar with specific aspects of each antibody infusion they administer.
Schmidt
Kristi V
KV
Department of Clinical Research, Maine Center for Cancer Medicine and Blood Disorders, Scarborough, ME, USA.
Wood
Barbara A
BA
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000918:Antibody Specificity; D000951:Antigens, Neoplasm; D006801:Humans; D007167:Immunotherapy / Q000451:nursing* / Q000639:trends; D009369:Neoplasms / Q000451:nursing* / Q000628:therapy; D009859:Oncology Nursing; D014481:United States; D014486:United States Food and Drug Administration / Q000592:standards
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm