Adult stem cell specification by Wnt signaling in muscle regeneration.
Recently, we describe a biological role for endogenous CD45+ stem cells in maintaining muscle integrity by participating in regeneration. Our experiments further establish that Wnt-signaling is the mechanism by which resident CD45+ adult stem cells are induced to undergo myogenic specification during muscle regeneration. Importantly, our study suggests that targeting the Wnt-pathway represents a promising therapeutic approach for the treatment of neuromuscular degenerative diseases.
Seale
Patrick
P
Ottawa Health Research Institute, Molecular Medicine Program, Ottawa, Ontario, Canada.
Polesskaya
Anna
A
Rudnicki
Michael A
MA
D000818:Animals; D019070:Cell Lineage / Q000235:genetics / Q000502:physiology; D017493:Leukocyte Common Antigens / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D012038:Regeneration; D032496:Satellite Cells, Skeletal Muscle / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000502:physiology; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D017493:Leukocyte Common Antigens