The viral potassium channel Kcv: structural and functional features.
The chlorella virus PBCV-1 was the first virus found to encode a functional potassium channel protein (Kcv). Kcv is small (94 aa) and basically consists of the M1-P-M2 (membrane-pore-membrane) module typical of the pore regions of all known potassium channels. Kcv forms functional channels in three heterologous systems. This brief review discusses the gating, permeability and modulation properties of Kcv and compares them to the properties of bacterial and mammalian K+ channels.
Gazzarrini
Sabrina
S
Department of Biology, CNR-IBF Unità di Milano, Università degli Studi di Milano, Via Celoria 26, 20133 Milano, Italy.
Severino
Maria
M
Lombardi
Mara
M
Morandi
Marzia
M
DiFrancesco
Dario
D
Van Etten
James L
JL
Thiel
Gerhard
G
Moroni
Anna
A
D000595:Amino Acid Sequence; D000818:Animals; D001464:Barium / Q000494:pharmacology; D055592:Biophysical Phenomena; D001703:Biophysics; D016466:CHO Cells; D006224:Cricetinae; D011088:DNA Ligases / Q000378:metabolism / Q000502:physiology; D007700:Kinetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017862:Phycodnaviridae / Q000378:metabolism*; D011188:Potassium / Q000737:chemistry / Q000378:metabolism; D015221:Potassium Channels / Q000737:chemistry* / Q000502:physiology*; D017434:Protein Structure, Tertiary; D018075:RNA, Complementary / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins; D014982:Xenopus laevis
C405463:Kcv potassium channel, Chlorella virus; D015221:Potassium Channels; D018075:RNA, Complementary; D014764:Viral Proteins; D001464:Barium; C110456:Chlorella virus DNA ligase; D011088:DNA Ligases; D011188:Potassium