The radiation biology of radioimmunotherapy.
The treatment of cancer is a wide and varied field, encompassing many methods and modalities. Radioimmunotherapy is a technique which utilizes the ablative properties of radiation by delivering radioactive particles directly to the tumour cells. This paper presents a summary of the research evidence that relates to the optimization of the effect of radioimmunotherapy. It includes discussion on the appropriate choice of radionuclide and monoclonal antibody; methods of increasing the radiation dose absorbed by the tumour; techniques available to increase the effect that the absorbed dose has on the tumour; and methods of protecting critical healthy tissue, particularly the bone marrow, from the effects of the radiation administered.
Dixon
K L
KL
Department of Physics, The University of British Colombia, Canada. katdixon@physics.ubc.ca
D001855:Bone Marrow Diseases / Q000209:etiology / Q000517:prevention & control; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D010346:Patient Care Management / Q000379:methods; D011832:Radiation Injuries / Q000209:etiology / Q000517:prevention & control; D011853:Radiobiology / Q000379:methods*; D016499:Radioimmunotherapy / Q000009:adverse effects / Q000379:methods*; D011868:Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D019275:Radiopharmaceuticals / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome
D011868:Radioisotopes; D019275:Radiopharmaceuticals