Influence of preservation solution on early lung function (Euro-Collins vs Perfadex).
BACKGROUND
This clinical study was performed to evaluate the efficiency of 2 different preservation solutions (Euro-Collins [EC] vs Perfadex [P]) on organ function in human lung transplantation.


METHODS
The donor lungs for 46 patients were flushed either with EC solution (25 cases, EC group) or Perfadex (21 cases, P group). Transplant function was assayed using PaO2/FiO2 ratio after transplantation upon intensive care unit (ICU) arrival and at 12 and 24 hours later (T1, T2, and T3, respectively). We also compared the duration of mechanical ventilatory support and ICU stay.


RESULTS
The PO2/FiO2 ratio was significantly better in the P than EC group at T1, T2, and T3. The duration of mechanical ventilatory support and ICU stay were lower also in P group, whereas age, sex, aetiology of lung disease, donor, PaO2/FiO2 ratio, and ischemia time did not show differences between the 2 groups.


CONCLUSIONS
Our data on graft function tend to confirm better graft preservation using the P preservation solution.
Rabanal
J M
JM
Department of Anesthesiology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
Ibañez
A M
AM
Mons
R
R
Gonzalez
A M
AM
Carbajo
M
M
Ortega
J
J
Zurbano
F
F
D006801:Humans; D008168:Lung / Q000187:drug effects / Q000502:physiology; D016040:Lung Transplantation / Q000502:physiology*; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D010546:Perphenazine / Q000494:pharmacology*
D019188:Organ Preservation Solutions; D010546:Perphenazine; D010100:Oxygen