Comparison of the effectiveness of single intrauterine insemination (IUI) versus double IUI per cycle in infertile patients.
OBJECTIVE
To compare a single periovulatory intrauterine insemination (IUI) with a regimen based on double IUI, performed during preovulatory and periovulatory periods, in patients undergoing controlled ovarian hyperstimulation (COH).


METHODS
Prospective, randomized study.


METHODS
Infertility and endocrinology units of a medical university.


METHODS
One hundred ten patients with male factor, cervical factor, and unexplained infertility who were undergoing 486 cycles of COH with IUI.


METHODS
The patients were randomly divided into two groups. One group underwent single IUI in the first cycle and double IUI in the second cycle; this alternating pattern was continued up to six cycles unless pregnancy occurred. For patients in the second group, double IUI was performed in the first cycle and single IUI in the second cycle; this pattern was repeated as in the first group.


METHODS
Relationship of single and double IUI to rates of clinical pregnancy and abortion.


RESULTS
Forty-two women became pregnant, with an overall pregnancy rate per cycle of 8.6% and pregnancy rate per couple of 38.2%. Pregnancy rate per cycle was 7.9% in single IUI cycles and was 9.4% in double IUI cycles; these findings were not statistically significant.


CONCLUSIONS
Among patients undergoing COH-IUI, results of single and double IUI do not statistically differ.
Alborzi
Saeed
S
Division of Infertility and Endoscopy, Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran. alborzis@sums.ac.ir
Motazedian
Shahdokht
S
Parsanezhad
Mohammad E
ME
Jannati
Sima
S
D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D005260:Female; D006801:Humans; D015994:Incidence; D007246:Infertility / Q000628:therapy*; D007317:Insemination, Artificial, Homologous / Q000379:methods*; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D011272:Pregnancy, Multiple; D016896:Treatment Outcome; D014427:Twins