Oxygen and glucose sensing by carotid body glomus cells.
Carotid body glomus cells sense hypoxia through the inhibition of plasmalemmal K(+) channels, which leads to Ca(2+) influx and transmitter release. Although the mechanism of O(2) sensing remains enigmatic, it does not seem to depend on cellular redox status or inhibition of mitochondrial electron transport. Hypoxia inducible factors appear to be necessary for the expression of the O(2) sensor and carotid body remodeling in chronic hypoxia, but are not directly involved in acute O(2) sensing. Glomus cells are also rapidly activated by reductions of glucose concentration due to inhibition of K(+) channels. These cells function as combined O(2) and glucose sensors that help to prevent neuronal damage by acute hypoxia and/or hypoglycemia.
López-Barneo
José
J
Laboratorio de Investigaciones Biomédicas, Departamento de Fisiología and Hospital Universitario Virgen del Rocío, Universidad de Sevilla, Avenida Manuel Siurot s/n E-41013 Seville, Spain. Jose.L.Barneo.sspa@juntadeandalucia.es
D000818:Animals; D002344:Carotid Body / Q000187:drug effects / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism* / Q000494:pharmacology
D005947:Glucose; D010100:Oxygen