Association of estrogen receptor alpha and beta3-adrenergic receptor polymorphisms with endometrial cancer.
OBJECTIVE
To investigate the association of estrogen receptor alpha and beta3-adrenergic receptor polymorphisms with endometrial cancer risk in Kagoshima, Japan.


METHODS
Ninety-two patients with endometrial cancer and 65 healthy women were enrolled in this study. Blood samples were collected, and deoxyribonucleic acid (DNA) was extracted. Estrogen receptor alpha and beta3-adrenergic receptor gene variants were analyzed by restriction fragment length polymorphisms using the restriction enzymes, Pvu II, Xba I for estrogen receptor alpha, and Mva I for beta3-adrenergic receptor. Multivariable logistic regression analysis was performed, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.


RESULTS
The Pvu II PP genotype was associated with a decreased risk of endometrial cancer (multivariable OR 0.23; 95% CI 0.07, 0.82) compared with the pp genotype. The Xba I XX genotype was associated with a decreased risk for endometrial cancer (multivariable OR 0.26; 95% CI 0.09, 0.79) compared with the xx genotype. The Mva I variants were not associated with endometrial cancer risk (multivariable OR 0.55; 95% CI 0.20, 1.51).


CONCLUSIONS
Estrogen receptor alpha polymorphisms, but not beta3-adrenergic receptor gene, may be associated with a risk of endometrial cancer.
Iwamoto
Ichiro
I
Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, Kagoshima, Japan. ichiro@m.kufm.kagoshima-u.ac.jp
Fujino
Toshinori
T
Douchi
Tsutomu
T
Nagata
Yukihiro
Y
D017677:Age Distribution; D016022:Case-Control Studies; D015331:Cohort Studies; D016001:Confidence Intervals; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000235:genetics*; D047628:Estrogen Receptor alpha; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008593:Menopause; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011336:Probability; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D011960:Receptors, Estrogen / Q000235:genetics*; D012016:Reference Values; D018570:Risk Assessment
D047628:Estrogen Receptor alpha; D022702:Receptors, Adrenergic, beta-3; D011960:Receptors, Estrogen