title: Biological dosimetry in Russian and Italian astronauts.
abstract: Large uncertainties are associated with estimates of equivalent dose and cancer risk for crews of long-term space missions. Biological dosimetry in astronauts is emerging as a useful technique to compare predictions based on quality factors and risk coefficients with actual measurements of biological damage in-flight. In the present study, chromosomal aberrations were analyzed in one Italian and eight Russian cosmonauts following missions of different duration on the MIR and the international space station (ISS). We used the technique of fluorescence in situ hybridization (FISH) to visualize translocations in chromosomes 1 and 2. In some cases, an increase in chromosome damage was observed after flight, but no correlation could be found between chromosome damage and flight history, in terms of number of flights at the time of sampling, duration in space and extra-vehicular activity. Blood samples from one of the cosmonauts were exposed in vitro to 6 MeV X-rays both before and after the flight. An enhancement in radiosensitivity induced by the spaceflight was observed.
authors.affiliation: Radiation Oncology Department, Karmanos Cancer Institute, Detroit, MI 48201-2013, USA.
authors.forename: O
authors.initials: O
authors.lastname: Greco
authors.forename: M
authors.initials: M
authors.lastname: Durante
authors.forename: G
authors.initials: G
authors.lastname: Gialanella
authors.forename: G
authors.initials: G
authors.lastname: Grossi
authors.forename: M
authors.initials: M
authors.lastname: Pugliese
authors.forename: P
authors.initials: P
authors.lastname: Scampoli
authors.forename: G
authors.initials: G
authors.lastname: Snigiryova
authors.forename: G
authors.initials: G
authors.lastname: Obe
mesh_terms: D018480:Astronauts; D002869:Chromosome Aberrations / Q000145:classification / Q000706:statistics & numerical data*; D003359:Cosmic Radiation; D004307:Dose-Response Relationship, Radiation; D018478:Extravehicular Activity; D006801:Humans; D007558:Italy; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects*; D009381:Neoplasms, Radiation-Induced / Q000517:prevention & control; D016273:Occupational Exposure; D011829:Radiation Dosage; D018570:Risk Assessment; D012426:Russia; D013026:Space Flight