Magnetic resonance imaging correlates of attention-deficit/hyperactivity disorder in children.
This study compared magnetic resonance imaging size differences in several brain regions and neurocognitive function in a group of male and female children with attention-deficit/hyperactivity disorder (ADHD) with no comorbid learning disorders with a normal control group of children. The ADHD group demonstrated smaller total brain, superior prefrontal, and right superior prefrontal volumes, as well as significantly smaller areas for cerebellar lobules I-V and VIII-X, total corpus callosum area, and splenium. No group differences were observed for the inferior prefrontal, caudate, or cerebellar volumes, or for the area of cerebellar lobules VI-VII. In the ADHD group but not in the control group, greater right superior prefrontal volume predicted poorer performance on a test of sustained attention. Patterns of brain abnormality did not differ in male and female children with ADHD.
Hill
Dina E
DE
Center for Neuropsychological Services, Department of Psychiatry, Albuquerque 87131, USA. dhill@salud.unm.edu
Yeo
Ronald A
RA
Campbell
Richard A
RA
Hart
Blaine
B
Vigil
Janet
J
Brooks
William
W
D001289:Attention Deficit Disorder with Hyperactivity / Q000473:pathology* / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D002648:Child; D003072:Cognition Disorders / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012737:Sex Factors