title: Oncocytic adenocarcinoma of the rectum with diffuse intra-luminal microcalcifications: the first reported case.
abstract: Several histological variants of colorectal carcinoma have been reported, some of them bearing prognostic significance, others only incidental findings showing unusual morphological features. The current report was aimed to describe the histological, immunohistochemical and ultrastructural features of an oncocytic adenocarcinoma of the rectum occurring in a 66-year-old woman. Histologically, it was a moderately differentiated adenocarcinoma composed by glandular structures lined by eosinophilic cells. The latter showed abundant granular cytoplasm and large nuclei with prominent nucleoli. Several glandular structures contained intraluminal, basophilic and non-birifrangent microcalcifications. The tumour cells displayed consistent anti-mitochondrial antigen, carcinoembryonic antigen, p53, CDX2 and cytokeratin 20 immunoreactivity. Ultrastructurally, more than 80% of the cytoplasmic area was occupied by abnormal mitochondria, while exocrine or endocrine granules were undetectable. The tumour infiltrated the intestinal wall through the subserosal tissue, but lymph node or distant metastases were absent. The patient is disease free 22 months after surgery. Based on the above features, this case could be appropriately named oncocytic adenocarcinoma with intraluminal microcalcifications. Like gastric neoplasms showing similar morphologic features, this tumour might have a better prognosis, and the presence of microcalcifcations could help its proper recognition at a pre-operative stage.
authors.affiliation: Department of Pathological Anatomy and Genetics, University of Bari, Bari, Italy.
authors.forename: Domenico
authors.initials: D
authors.lastname: Piscitelli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ingravallo
authors.forename: Leonardo
authors.initials: L
authors.lastname: Resta
authors.forename: Maria G
authors.initials: MG
authors.lastname: Fiore
authors.forename: Eugenio
authors.initials: E
authors.lastname: Maiorano
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure; D000368:Aged; D002114:Calcinosis / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D012004:Rectal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure