title: Turnover of lymphocytes and conceptual paradigms in HIV infection.
abstract: Prevailing views concerning the pathogenic mechanisms of AIDS have shifted from models that focus primarily on direct HIV-mediated killing of CD4+ T cells to models that emphasize the pathogenic role of generalized immune system activation. The observation that increases in T cell turnover seen in HIV-infected individuals primarily reflect increased proliferation of effector-memory T cells supports the concept that chronic immune activation plays a prominent, if not predominant, role in the pathogenesis of AIDS.
authors.affiliation: Emory Vaccine Center, 954 Gatewood Road, Atlanta, Georgia 30329, USA.
authors.forename: Guido
authors.initials: G
authors.lastname: Silvestri
authors.forename: Mark B
authors.initials: MB
authors.lastname: Feinberg
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006706:Homeostasis; D006801:Humans; D007156:Immunologic Memory; D018655:Lymphocyte Count; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000502:physiology*