Voriconazole treatment of presumptive disseminated Aspergillus infection in a child with acute leukemia.
Invasive fungal infection continues to pose a significant threat to immunocompromised patients. The authors describe a pediatric patient receiving chemotherapy for acute undifferentiated leukemia who developed presumptive Aspergillus species infection disseminated to lung, liver, spleen, and bone. The authors report the successful treatment of this infection with the addition of voriconazole, a triazole antimycotic, to treatment with amphotericin and surgical debridement, in the setting of ongoing intensive chemotherapy.
Shouldice
Elizabeth
E
Dalhousie University Medical School, Halifax, Nova Scotia, Canada.
Fernandez
Conrad
C
McCully
Barbara
B
Schmidt
Matthias
M
Fraser
Robert
R
Cook
Chris
C
D000208:Acute Disease; D000293:Adolescent; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D003131:Combined Modality Therapy; D003646:Debridement; D004359:Drug Therapy, Combination; D005260:Female; D006505:Hepatitis / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008172:Lung Diseases, Fungal / Q000188:drug therapy; D009894:Opportunistic Infections / Q000188:drug therapy; D010019:Osteomyelitis / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use*; D012074:Remission Induction; D012446:Sacroiliac Joint / Q000382:microbiology / Q000601:surgery; D013158:Splenic Diseases / Q000188:drug therapy / Q000382:microbiology; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D065819:Voriconazole