title: Regional correlation by color-coded tissue Doppler to quantify improvements in mechanical left ventricular synchrony after biventricular pacing therapy.
abstract: Cardiac resynchronization therapy (CRT) can improve cardiac function in patients with heart failure and left bundle branch block. To test a new synchrony index derived from mitral annular velocity by color tissue Doppler, 19 subjects were studied: 9 patients with heart failure and left bundle branch block at baseline and at 1, 3 and 6 months after CRT and 10 normal controls. The synchrony index in patients with heart failure was less than that in controls at baseline (r = 0.60 +/- 0.13 vs 0.94 +/- 0.02; p <0.01), but improved at 6 months after CRT (r = 0.77 +/- 0.09; p <0.05 vs baseline).
authors.affiliation: Cardiovascular Institute, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA.
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kanzaki
authors.forename: Didier
authors.initials: D
authors.lastname: Jacques
authors.forename: L Elif
authors.initials: LE
authors.lastname: Sade
authors.forename: Donald A
authors.initials: DA
authors.lastname: Severyn
authors.forename: David
authors.initials: D
authors.lastname: Schwartzman
authors.forename: John
authors.initials: J
authors.lastname: Gorcsan
mesh_terms: D000368:Aged; D002037:Bundle-Branch Block / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy*; D002304:Cardiac Pacing, Artificial; D018618:Echocardiography, Doppler, Color; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D017063:Outcome Assessment, Health Care; D015203:Reproducibility of Results; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy*