title: Non-invasive evaluation of coronary artery bypass grafts using multi-slice computed tomography: initial clinical experience.
abstract: Recurrence of angina pectoris in patients with previous coronary artery bypass graft (CABG) surgery due to severe coronary artery disease (CAD) is a common problem. Non-invasive imaging of coronary artery bypass grafts by computed tomography was first described in the early 1980s. Meanwhile, multi-slice computed tomography (MSCT) is now available. This new technique allows detection of coronary lesions with good sensitivity and specificity due to continuous improvement and modification of this method. The aim of this study was to investigate whether stenosis or occlusion of CABG can be detected by MSCT. Ten consecutive male patients (mean age 61+/-9.1 years) with previous CABG surgery and 21 bypass grafts (14 venous grafts, seven arterial grafts) were included in this study. Conventional coronary angiography and MSCT angiography (MSCTA) were performed in all patients. MSCTA results were compared with coronary angiography in regard of visualization and lesion detection in CABG. The analysis of MSCTA was performed blinded to the angiographic results. It was found that 18 of 21 bypass grafts (86%) were analyzable by MSCTA: seven of 21 (33%) grafts showed a significant stenosis (>75%), while six of them were detected by MSCTA (sensitivity: 86%, positive predictive value: 0.75). Dissection of one arterial graft could not be evaluated by MSCTA. Twelve of 13 grafts without severe lesion showed no significant stenosis in MSCTA (negative predictive value: 0.86). All grafts without severe lesions by MSCT showed no significant lesion in X-ray angiography (specificity: 100%). MSCTA is a promising new method for the detection of lesions in coronary artery bypass grafts. However, these data based on a small number has to be reevaluated by larger studies.
authors.affiliation: Department of Internal Medicine, Eberhard-Karls-University, Otfried-Mueller-Str 10, 72076, Tuebingen, Germany.
authors.forename: Christof
authors.initials: C
authors.lastname: Burgstahler
authors.forename: Axel
authors.initials: A
authors.lastname: Kuettner
authors.forename: Andreas F
authors.initials: AF
authors.lastname: Kopp
authors.forename: Christian
authors.initials: C
authors.lastname: Herdeg
authors.forename: Jens
authors.initials: J
authors.lastname: Martensen
authors.forename: Claus D
authors.initials: CD
authors.lastname: Claussen
authors.forename: Stephen
authors.initials: S
authors.lastname: Schroeder
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D023921:Coronary Stenosis / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D014654:Vascular Patency