Liver transplantation for autoimmune hepatitis: fulminant versus chronic hepatitis presentation.
OBJECTIVE
The aim of this study was to analyse long-term outcomes of patients with liver transplantation for autoimmune hepatitis and to determine if fulminant/subfulminant hepatic failure (FSHF) at presentation was a predictor of outcome after ortothopic liver transplantation.


METHODS
Between April 1990 and October 2002, 18 patients with autoimmune hepatitis underwent 21 liver transplants. Three patients were excluded because of coexisting causes of hepatitis. Seven patients had FSHF and eight patients had chronic disease. The initial immunosuppressive regimen was cyclosporine based in 80%, and all but one patient received steroids or azathioprine.


RESULTS
Mean age at time of transplant was 44.2+/-15.5 years. Patients were followed for 38.9+/-29.6 months. Five patients (33.3%) had seven episodes of acute rejection (two steroid-resistant). Three patients developed chronic rejection. One patient displayed histologically proven recurrent autoimmune hepatitis. Actuarial patient and graft survival rates at 1 and 5 years were 80% and 56% and 78.6% and 51%, respectively. No differences in the clinical characteristics of the patients, rates of acute or chronic rejection episodes, end biliary or arterial complications were observed between FSHF and chronic autoimmune hepatitis. The study suggests a better survival for autoimmune FSHF (P=.003).


CONCLUSIONS
Liver transplant is indicated for patients displaying autoimmune chronic liver disease and FSHF with similar clinical courses at however, patients with FSHF at presentation had better survivals.
Núñez-Martínez
O
O
Liver Transplantation Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain. onumar@inicia.es
De la Cruz
G
G
Salcedo
M
M
Molina
J
J
De Diego
A
A
Ripoll
C
C
Calleja
J
J
Alvarez
E
E
Clemente
G
G
D000208:Acute Disease; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D006084:Graft Rejection / Q000453:epidemiology; D019693:Hepatitis, Autoimmune / Q000401:mortality / Q000601:surgery*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D017093:Liver Failure / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000276:immunology / Q000401:mortality; D012189:Retrospective Studies; D016019:Survival Analysis
D007166:Immunosuppressive Agents