Polymorphisms of IL-4, IL-4R alpha, and AICDA genes in adult allergic asthma.
The relationship between 3 polymorphisms sites [interleulin-4 (IL-4), IL-4 receptor (IL-4R) alpha chain and activation-induced cytidine deaminase (AICDA)] and adult allergic asthma in China was studied. By using case-control method, DNA and clinical data were obtained from allergic asthmatic patients and compared with those in the control subjects. The subjects were genotyped for the IL-4 C-589T promoter polymorphism, the IL-4R alpha chain Q576R and the AICDA C8408T by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The results showed that the IL-4 C-589T was not associated with adult allergic asthma in China. However, the IL-4R alpha chain 576R/R and AICDA 8408T/T frequency was significantly increased in allergic asthma group as compared with that in the control group [odd ratio (OR) = 3.797 and 9.127, respectively; P < 0.01)] and was correlated with the increased plasma total IgE. These data suggested that the IL-4R alpha chain 576R/R and AICDA 8408T/T genotypes confer genetic susceptibility to adult allergic asthma in China.
Cui
Tianpen
T
Immunology Laboratory, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
Wang
Lin
L
Wu
Jianmin
J
Hu
Lihua
L
Xie
Jungang
J
D000328:Adult; D000483:Alleles; D001249:Asthma / Q000209:etiology / Q000235:genetics*; D003564:Cytidine Deaminase / Q000235:genetics*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D015847:Interleukin-4 / Q000235:genetics*; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length; D012323:RNA Processing, Post-Transcriptional; D019948:Receptors, Interleukin-4 / Q000235:genetics*; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D019948:Receptors, Interleukin-4; D015847:Interleukin-4; D007073:Immunoglobulin E; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D003564:Cytidine Deaminase