title: O-arylmandelic acids as highly selective human PPAR alpha/gamma agonists.
abstract: A new class of O-arylmandelic acid PPAR agonists show excellent anti-hyperglycemic efficacy in a db/db mouse model of DM2. These PPARalpha-weighted agonists do not show the typical PPARgamma associated side effects of BAT proliferation and cardiac hypertrophy in a rat tolerability assay.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co. Inc., PO Box 2000 Rahway, NJ 07065, USA. alan_adams@merck.com
authors.forename: Alan D
authors.initials: AD
authors.lastname: Adams
authors.forename: Zao
authors.initials: Z
authors.lastname: Hu
authors.forename: Derek
authors.initials: D
authors.lastname: von Langen
authors.forename: Adonis
authors.initials: A
authors.lastname: Dadiz
authors.forename: Alex
authors.initials: A
authors.lastname: Elbrecht
authors.forename: Karen L
authors.initials: KL
authors.lastname: MacNaul
authors.forename: Joel P
authors.initials: JP
authors.lastname: Berger
authors.forename: Gaochao
authors.initials: G
authors.lastname: Zhou
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Doebber
authors.forename: Roger
authors.initials: R
authors.lastname: Meurer
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Forrest
authors.forename: David E
authors.initials: DE
authors.lastname: Moller
authors.forename: A Brian
authors.initials: AB
authors.lastname: Jones
mesh_terms: D000818:Animals; D008333:Mandelic Acids / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D011485:Protein Binding / Q000187:drug effects / Q000502:physiology; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists* / Q000378:metabolism; D014157:Transcription Factors / Q000819:agonists* / Q000378:metabolism
chemical_list: D008333:Mandelic Acids; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors