Transformation to aggressive B-cell lymphoma: morphology, immunophenotype, and molecular characteristics.
Many indolent lymphomas are destined for eventual transformation to aggressive B-cell lymphomas, an event with significant impact on therapy and outcome. Specific morphologic patterns of transformation are described for common subtypes of low-grade B-cell lymphoma. The discussion highlights immunophenotypic, molecular, and genetic characteristics of lymphoma transformation.
Said
Jonathan
J
David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, U.S.A. Jsaid@mednet.ucla.edu
D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology*