[The role of electro-mechanical coupling in development of experimental atrophy of skeletal muscles].
The available data of functioning of excitation-contraction coupling in atrophied skeletal muscles after denervation, immobilization, or hindlimb unloading, were summed up and analyzed. The analogy and differences between activation of contraction under these experimental conditions were elucidated in order to understand possible mechanisms of adaptation of the excitation-contraction coupling to different modes of atrophy. It was supposed that denervation and immobilization are the pathogenic factors for triggering the excitation-contraction coupling, whereas unloading is the factor which evokes active adaptation of this system.
Nasledov
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GA
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Acad. Sci., 194223, St. Petersburg, pr. M. Toreza, 44, Russia.
D000222:Adaptation, Physiological; D000818:Animals; D002118:Calcium / Q000378:metabolism; D006801:Humans; D018472:Hypogravity; D007103:Immobilization; D009121:Muscle Denervation; D018482:Muscle, Skeletal / Q000294:innervation / Q000378:metabolism / Q000502:physiology; D009133:Muscular Atrophy / Q000209:etiology* / Q000378:metabolism
D002118:Calcium
O roli élektromekhanicheskoĭ sviazi v razvitii éksperimental'noĭ atrofii skeletnykh myshts.