title: Relay and control of abscisic acid signaling.
abstract: Insights into the signal transduction of the phytohormone abscisic acid (ABA) have unfolded dramatically in the past few years and reveal an unanticipated complexity. Knockout lines and RNA-interference technology, together with protein interaction analyses, have been used to identify many of the cellular components that regulate or modulate ABA responses. ABA signaling is characterized by a plethora of intracellular messengers. This may reflect the function of ABA in integrating several stress responses and antagonizing pathways via cross-talk, but it hampers the establishment of a unifying concept. Transcriptome analyses have unraveled more than a thousand genes that are differentially regulated by ABA, and these ABA-mediated changes in gene expression translate to major changes in proteome expression. ABA-induced mechanisms that re-adjust cellular protein expression are just surfacing. ABA-response-specific transcription factors have a well-established function in that process and, recently, it has also become clear that phytohormone signaling enforces a sophisticated interference with protein expression at the posttranscriptional level. This interference includes both targeted proteolysis and the regulation of the translation of specific mRNAs by RNA-binding proteins.
authors.affiliation: Lehrstuhl für Botanik, Technische Universität München, Biologikum Weihenstephan, Am Hochanger 4, 85354 Freising, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Himmelbach
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Erwin
authors.initials: E
authors.lastname: Grill
mesh_terms: D000040:Abscisic Acid / Q000494:pharmacology*; D010944:Plants / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D025941:Protein Interaction Mapping; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D000040:Abscisic Acid