title: Lipoteichoic acid and peptidoglycan from Staphylococcus aureus synergistically induce neutrophil influx into the lungs of mice.
abstract: Staphylococcus aureus is an important pathogen in nosocomial pneumonia. Lipoteichoic acid (LTA) and peptidoglycan (PepG) are part of the staphylococcal cell wall. Here we show that LTA and PepG act in synergy to cause polymorphonuclear cell recruitment in the pulmonary compartment during S. aureus pneumonia.
authors.affiliation: Laboratory of Experimental Internal Medicine, Utrecht University, Utrecht, The Netherlands. j.c.leemans@amc.uva.nl
authors.forename: Jaklien C
authors.initials: JC
authors.lastname: Leemans
authors.forename: Mirjam
authors.initials: M
authors.lastname: Heikens
authors.forename: Kok P M
authors.initials: KP
authors.lastname: van Kessel
authors.forename: Sandrine
authors.initials: S
authors.lastname: Florquin
authors.forename: Tom
authors.initials: T
authors.lastname: van der Poll
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology* / Q000494:pharmacology; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology; D002465:Cell Movement; D004195:Disease Models, Animal; D004357:Drug Synergism; D004797:Enzyme-Linked Immunosorbent Assay; D007150:Immunohistochemistry; D008070:Lipopolysaccharides / Q000276:immunology* / Q000494:pharmacology; D008168:Lung / Q000276:immunology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000276:immunology*; D010457:Peptidoglycan / Q000276:immunology* / Q000494:pharmacology; D011023:Pneumonia, Staphylococcal / Q000276:immunology* / Q000473:pathology; D013211:Staphylococcus aureus / Q000276:immunology; D013682:Teichoic Acids / Q000276:immunology* / Q000494:pharmacology
chemical_list: D000942:Antigens, Bacterial; D008070:Lipopolysaccharides; D010457:Peptidoglycan; D013682:Teichoic Acids; C009900:lipoteichoic acid