Role of cancer cell-stroma interaction in invasive growth of cancer cells.
Invasive growth is one of the hallmarks of cancer malignancy. To date, a significant body of evidence is accumulating in favor of the notion that invasive growth results from the cross-talk between cancer cells and the host stromal cells, comprising fibroblasts (myofibroblasts), endothelial cells, and leukocytes, all of which are themselves invasive. In this review we describe cross-talk between invasive cancer cells and host stromal fibroblasts and an impact of pericellular microenvironment on the invasive phenotype of cancer cells, focusing on two molecules, extracellular matrix metalloproteinase inducer (EMMPRIN, also known as tumor cell-derived collagenase stimulatory factor, basigin, CD147) and hepatocyte growth factor (HGF, also known as scatter factor). Both molecules are deeply involved in the regulation of invasion-associated cellular activities, such as pericellular proteolysis, migration and ectopic survival of cancer cells.
Kataoka
Hiroaki
H
Second Department of Pathology, Miyazaki Medical College, Kiyotake, Miyazaki, Japan. mejina@fc.miyazaki-med.ac.jp
Tanaka
Hiroyuki
H
Nagaike
Koki
K
Uchiyama
Shuichiro
S
Itoh
Hiroshi
H
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D051926:Basigin; D002450:Cell Communication / Q000502:physiology*; D005109:Extracellular Matrix / Q000378:metabolism; D005347:Fibroblasts / Q000502:physiology*; D017228:Hepatocyte Growth Factor / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D011498:Protein Precursors / Q000378:metabolism; D053491:Proteinase Inhibitory Proteins, Secretory; D012697:Serine Endopeptidases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014357:Trypsin / Q000502:physiology
D015703:Antigens, CD; D000951:Antigens, Neoplasm; C497886:BSG protein, human; D008562:Membrane Glycoproteins; D011498:Protein Precursors; D053491:Proteinase Inhibitory Proteins, Secretory; C109149:SPINT1 protein, human; C086013:pro-hepatocyte growth factor; D051926:Basigin; D017228:Hepatocyte Growth Factor; D012697:Serine Endopeptidases; C485595:matriptase; C485596:ST14 protein, human; D014357:Trypsin