Induction of antitumour immunity using survivin peptide-pulsed dendritic cells in a murine lymphoma model.
Survivin is overexpressed in several types of haematological malignancies making it an attractive target for therapeutic cytotoxic T-lymphocyte responses. Here, we identify two peptide epitopes derived from the murine survivin protein and demonstrate that Balb/c mice treated with syngeneic dendritic cells pulsed with the survivin epitopes were able to reject an otherwise lethal tumour inoculation of the A20 lymphoma. For the first time, these data provide evidence for the use of survivin peptide epitopes in T cell-based immunotherapeutic concepts against a B-cell lymphoma in vivo.
Siegel
Sandra
S
Department of Haematology, General Hospital St Georg, Hamburg, and Institute of Immunology, University of Kiel, Kiel, Germany.
Wagner
Andreas
A
Schmitz
Norbert
N
Zeis
Matthias
M
D000818:Animals; D019496:Cancer Vaccines / Q000276:immunology*; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology / Q000637:transplantation*; D000939:Epitopes / Q000276:immunology; D051034:Inhibitor of Apoptosis Proteins; D016393:Lymphoma, B-Cell / Q000276:immunology* / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D008869:Microtubule-Associated Proteins / Q000276:immunology*; D009363:Neoplasm Proteins; D009368:Neoplasm Transplantation; D010446:Peptide Fragments / Q000276:immunology; D016019:Survival Analysis; D000077022:Survivin; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014407:Tumor Cells, Cultured; D014611:Vaccination / Q000379:methods
C107489:BIRC5 protein, human; D019496:Cancer Vaccines; D000939:Epitopes; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D010446:Peptide Fragments; D000077022:Survivin