title: A short-term study of the additive effect of latanoprost 0.005% and brimonidine 0.2%.
abstract: OBJECTIVE
  To evaluate the short-term additive effects of latanoprost 0.005% and brimonidine 0.2%.
  
  
  METHODS
  This study was a randomized, double-masked, cross-over study that included 32 patients (32 eyes) with primary open-angle glaucoma or exfoliation glaucoma. On baseline day, intraocular pressure (IOP) was measured at 10 AM and 11 PM. Baseline IOP values were obtained by calculating the mean values for both eyes. After this process, latanoprost 0.005% was prescribed once a day during the first 5 days at 10 PM as the first test drug. During the second 5 days, twice a day brimonidine 0.2% or a placebo, as the second test drug, was added to the latanoprost at 9 AM and 10 PM. After a 4-week washout period, latanoprost 0.005% was prescribed once a day during the first 5 days at 10 PM and during the second 5 days, the second test drug, brimonidine or a placebo, was added to latanoprost, and the two drugs were prescribed twice a day for 5 days.
  
  
  RESULTS
  During the second 5 days, although an additional 2.53-3.10 mm Hg decrease in IOP was determined in the latanoprost+brimonidine group, there was no additional decrease in the latanoprost+placebo group.
  
  
  CONCLUSIONS
  This study showed that brimonidine and latanoprost have an additive IOP-lowering effect in open-angle glaucoma patients in the short term.
authors.affiliation: Department of Ophthalmology, School of Medicine, Cumhuriyet University, Sivas, Turkey. h_erdogan@ttnet.net.tr
authors.forename: Haydar
authors.initials: H
authors.lastname: Erdoğan
authors.forename: Ilker
authors.initials: I
authors.lastname: Toker
authors.forename: Mustafa Kemal
authors.initials: MK
authors.lastname: Arici
authors.forename: Ahmet
authors.initials: A
authors.lastname: Aygen
authors.forename: Ayşen
authors.initials: A
authors.lastname: Topalkara
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000068438:Brimonidine Tartrate; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004357:Drug Synergism; D005260:Female; D005901:Glaucoma / Q000188:drug therapy*; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage*; D011810:Quinoxalines / Q000008:administration & dosage*
chemical_list: D011461:Prostaglandins F, Synthetic; D011810:Quinoxalines; D000068438:Brimonidine Tartrate; D000077338:Latanoprost