[Correlation of immunomodulating effects induced by lysozyme and naphthoquinones in acute blood loss].
The role of erythrocytes in realization of interrelation of the immunomodulating effects of lysozyme and naphthoquinones in normal and under conditions of acute hemorrhage was studied. Interaction of lysozyme and menadione at the level of intact erythrocytes and their stroma resulted in formation of highly efficient immunomodulating factors. The effect of such factors under conditions of acute hemorrhage was mediated by cytokines of the spleen macrophagael cells.
Rybnikov
V N
VN
Kursk State Medical University.
Brovkina
I L
IL
D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004357:Drug Synergism; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology; D006470:Hemorrhage / Q000276:immunology*; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D009113:Muramidase / Q000494:pharmacology*; D009285:Naphthoquinones / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000276:immunology / Q000378:metabolism; D010837:Vitamin K 1 / Q000494:pharmacology; D024483:Vitamin K 3 / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D009285:Naphthoquinones; D024483:Vitamin K 3; D010837:Vitamin K 1; D009113:Muramidase
Vzaimosviaz' immunomoduliruiushchikh éffektov, vyzyvaemykh lizotsimom i naftokhinonami, pri ostroĭ krovopotere.