title: No association between a putative functional promoter variant in the dopamine beta-hydroxylase gene and schizophrenia.
abstract: OBJECTIVE
  Disturbances in catecholamine transmission have been implicated in schizophrenia. Dopamine beta-hydroxylase catalyses the conversion of dopamine to norepinephrine in noradrenergic cells. We attempted to investigate a putative functional promoter polymorphism in the dopamine beta-hydroxylase gene (DBH) for association with schizophrenia.
  
  
  METHODS
  Unrelated schizophrenic patients (n=155) and control subjects (n=436) were analysed with regard to the DBH -1021 C/T variant.
  
  
  RESULTS
  No significant allele or genotype differences were found.
  
  
  CONCLUSIONS
  The present results do not support a major involvement of the DBH gene in schizophrenia in the Swedish population investigated.
authors.affiliation: Department of Clinical Neuroscience, Psychiatry Section, HUBIN project, Karolinska Institute, SE-171 76 Stockholm, Sweden. erikj@ks.se
authors.forename: Erik G
authors.initials: EG
authors.lastname: Jönsson
authors.forename: Rami
authors.initials: R
authors.lastname: Abou Jamra
authors.forename: Johannes
authors.initials: J
authors.lastname: Schumacher
authors.forename: Lena
authors.initials: L
authors.lastname: Flyckt
authors.forename: Gunnar
authors.initials: G
authors.lastname: Edman
authors.forename: Kaj
authors.initials: K
authors.lastname: Forslund
authors.forename: Marja
authors.initials: M
authors.lastname: Mattila-Evenden
authors.forename: Gunnar
authors.initials: G
authors.lastname: Rylander
authors.forename: Marie
authors.initials: M
authors.lastname: Asberg
authors.forename: Lars
authors.initials: L
authors.lastname: Bjerkenstedt
authors.forename: Frits-Axel
authors.initials: FA
authors.lastname: Wiesel
authors.forename: Peter
authors.initials: P
authors.lastname: Propping
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Göran C
authors.initials: GC
authors.lastname: Sedvall
mesh_terms: D004299:Dopamine beta-Hydroxylase / Q000235:genetics*; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012016:Reference Values; D012559:Schizophrenia / Q000201:enzymology / Q000235:genetics*; D013548:Sweden
chemical_list: D004299:Dopamine beta-Hydroxylase