title: Multidrug resistance proteins and topoisomerase IIalpha expression in colon cancer: association with metastatic potential.
abstract: OBJECTIVE
  To investigate the role of multidrug resistance proteins and topoisomerase IIalpha in colon cancer.
  
  
  METHODS
  Tissue sections from 89 Dukes' stage B-D colon cancer patients were selected. The expression of multidrug resistance proteins and topoisomerase IIalpha in primary tumour cells was assessed by standard immunohistochemistry. The extent of their expression was measured by image analysis and was correlated with clinicopathological features of the patients.
  
  
  RESULTS
  P-glycoprotein was associated with the presence of lymph node metastasis (P=0.005), vessel invasion (P=0.0001) and perineural invasion (P=0.020).
  
  
  CONCLUSIONS
  P-glycoprotein is probably involved in the processes of local invasion and metastatic dissemination.
authors.affiliation: Department of Pathology, School of Medicine, National and Capodistrian University of Athens, Greece. alazaris@med.uoa.gr
authors.forename: Haralampos S
authors.initials: HS
authors.lastname: Zorzos
authors.forename: Andreas C
authors.initials: AC
authors.lastname: Lazaris
authors.forename: Penelope A
authors.initials: PA
authors.lastname: Korkolopoulou
authors.forename: Nikolaos G
authors.initials: NG
authors.lastname: Kavantzas
authors.forename: Sofia
authors.initials: S
authors.lastname: Tseleni-Balafouta
authors.forename: Efstratios S
authors.initials: ES
authors.lastname: Patsouris
authors.forename: Nikolaos V
authors.initials: NV
authors.lastname: Tsavaris
authors.forename: Panagiotis S
authors.initials: PS
authors.lastname: Davaris
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000378:metabolism*; D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D000236:Adenoma / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D003110:Colonic Neoplasms / Q000378:metabolism* / Q000473:pathology; D004250:DNA Topoisomerases, Type II / Q000378:metabolism*; D004268:DNA-Binding Proteins; D018432:Drug Resistance, Multiple / Q000502:physiology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D008207:Lymphatic Metastasis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism*; D009361:Neoplasm Invasiveness
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D004250:DNA Topoisomerases, Type II; D004268:DNA-Binding Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins