title: [Relation of serum prostate-specific antigen and the Gleason grade in patients with prostatic carcinoma].
abstract: The prostatic adenocarcinoma is one of the most frequent malignant tumors of men over 50 years of age. It is distinguished by aggressive clinical course and heterogeneous multifocal histomorphologic changes. PSA is the most reliable serum marker in diagnostics and observation of prostatic carcinoma, and Gleason's system of tumor-diferentiation grading is generally accepted way of determining the histologic grade. Gleason's system is correlated with serum levels of PSA and with biological behaviour of the tumor. We presented 40 patients with verified ACP in whom the level of serum PSA, Gleason's grade and score were compared. Highly significant correlation was found between serum level of PSA and the differentiation grade of the tumor--Gleason's grade and score. Combination of PSA parameters and Gleason's score enables correct estimation of tumor's behaviour and correct therapeutic protocol.
authors.affiliation: Vojna bolnica, Odsek za urologiju, Nis.
authors.forename: Sladana
authors.initials: S
authors.lastname: Zivković
authors.forename: Ljubinka
authors.initials: L
authors.lastname: Velicković
authors.forename: Milos
authors.initials: M
authors.lastname: Kostov
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Stojanović
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology; D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology
chemical_list: D017430:Prostate-Specific Antigen
vernacular_title: Odnos serumskog prostata specificnog antigena i Glisonovog gradusa kod bolesnika sa karcinomom prostate.