title: A neural survival factor is a candidate oncogene in breast cancer.
abstract: Using serial analysis of gene expression (SAGE), we identified a SAGE tag that was present only in invasive breast carcinomas and their lymph node metastases. The transcript corresponding to this SAGE tag, dermcidin (DCD), encodes a secreted protein normally expressed only in the pons of the brain and sweat glands. Array comparative genomic hybridization, fluorescence in situ hybridization, and immunohistochemical analyses determined that DCD is overexpressed in approximately 10% of invasive breast carcinomas; in some cases its overexpression is coupled with a focal copy number gain of its locus at 12q13.1, and its expression is associated with advanced clinical stage and poor prognosis. Expression of DCD in breast cancer cells promotes cell growth and survival and reduces serum dependency. Putative high- and low-affinity receptors for DCD are present on the cell surface of breast carcinomas and neurons of the brain. Based on these data we hypothesize that DCD may play a role in tumorigenesis by means of enhancing cell growth and survival in a subset of breast carcinomas.
authors.affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
authors.forename: Dale
authors.initials: D
authors.lastname: Porter
authors.forename: Stanislawa
authors.initials: S
authors.lastname: Weremowicz
authors.forename: Koei
authors.initials: K
authors.lastname: Chin
authors.forename: Pankaj
authors.initials: P
authors.lastname: Seth
authors.forename: Aparna
authors.initials: A
authors.lastname: Keshaviah
authors.forename: Jaana
authors.initials: J
authors.lastname: Lahti-Domenici
authors.forename: Young Kyung
authors.initials: YK
authors.lastname: Bae
authors.forename: Constance L
authors.initials: CL
authors.lastname: Monitto
authors.forename: Ana
authors.initials: A
authors.lastname: Merlos-Suarez
authors.forename: Jennifer
authors.initials: J
authors.lastname: Chan
authors.forename: Christine M
authors.initials: CM
authors.lastname: Hulette
authors.forename: Andrea
authors.initials: A
authors.lastname: Richardson
authors.forename: Cynthia C
authors.initials: CC
authors.lastname: Morton
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Marks
authors.forename: Mabel
authors.initials: M
authors.lastname: Duyao
authors.forename: Ralph
authors.initials: R
authors.lastname: Hruban
authors.forename: Edward
authors.initials: E
authors.lastname: Gabrielson
authors.forename: Rebecca
authors.initials: R
authors.lastname: Gelman
authors.forename: Kornelia
authors.initials: K
authors.lastname: Polyak
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D004273:DNA, Neoplasm; D020869:Gene Expression Profiling; D006801:Humans; D008969:Molecular Sequence Data; D009361:Neoplasm Invasiveness; D009857:Oncogenes; D017386:Sequence Homology, Amino Acid; D014407:Tumor Cells, Cultured
chemical_list: D004273:DNA, Neoplasm