Is poly(ADP-ribose) polymerase involved in bovine placental retention?
Poly(ADP-ribose) polymerase (PARP) is the enzyme which utilises NAD to synthesise poly(ADP-ribose) polymers. This process appears in response to DNA lesions. Oxidative stress, which might be involved in bovine placental retention, is the reason for oxidative DNA injury. In this mini-review, the relationship between PARP activity and bovine placental retention is discussed. The results of our experiments on PARP activity in placental tissues showed that the enzyme of 113 kDa and its cleavage products were present in retained as well as released fetal membranes. Western blotting technique showed different intensities in the staining of bands which might suggest different activities of the enzyme.
Kankofer
M
M
Department of Biochemistry, Faculty of Veterinary Medicine, Agricultural University, Lubartowska 58 a, Lublin 20-123, Poland. kankofer@agros.ar.lublin.pl
Guz
L
L
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000201:enzymology*; D004249:DNA Damage; D005260:Female; D018384:Oxidative Stress; D010920:Placenta / Q000201:enzymology; D018457:Placenta, Retained / Q000201:enzymology / Q000662:veterinary*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D011247:Pregnancy
D011065:Poly(ADP-ribose) Polymerases