[Genetic and biochemical approaches to individual sensitivity to drug preparations].
The paper addresses evolution of the concept of individual sensitivity to drugs, based on the new pharmacogenetic and pharmacogenomic approaches. The possibility of geno- and phenotypy of the pharmacodynamic and pharmacokinetic processes, aimed at establishing the parameters ensuring reliable prediction of the individual response of a patient. The promising pharmacogenomic methods will allow to create preparations directly acting upon defective genes or the related products. Factors limiting the development of pharmacogenomic methods, related to the lack of data on the structure and physiological properties of protein products and their metabolites, are considered.
Seredenin
S B
SB
Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Val'dman
E A
EA
D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D010597:Pharmacogenetics / Q000266:history*
Genetiko-biokhimicheskoe razvitie problemy individual'noĭ chuvstvitel'nosti k lekarstvennym sredstvam.