title: Helicobacter pylori seropositivity and hyperemesis gravidarum.
abstract: OBJECTIVE
  To investigate the possible association between Helicobacter pylori seropositivity and hyperemesis gravidarum.
  
  
  METHODS
  We designed a case-control study to compare the prevalence of H pylori seropositivity in women diagnosed with hyperemesis gravidarum to that in a control population recruited from 2 university-based clinics, 1 inner city and 1 suburban. Results were tested for statistical significance by chi 2, Student t test and unconditional logistic regression analysis.
  
  
  RESULTS
  Fifty-three subjects (30 inner city, 23 suburban) and 153 controls (75 inner city, 78 suburban) were enrolled. There was no significant difference in the prevalence of H pylori seropositivity between subjects and controls at either site (50% vs. 47%, P = .8 inner city; 17% vs. 13%, P = .6 suburban) or overall (36% vs. 29%, P = .39). In logistic regression analysis only race (African American) and age remained significantly associated with hyperemesis gravidarum, with adjusted odds ratios of 2.45 (95% CI 1.03-5.83) and .91 (95% CI .85-.98), respectively.
  
  
  CONCLUSIONS
  This study found no association between hyperemesis gravidarum and H pylori seropositivity in 2 populations with disparate H pylori seroprevalence.
authors.affiliation: Departments of Obstetrics and Gynecology, University of Wisconsin Medical School, Medical College of Wisconsin, Milwaukee, USA. gavin.jacobson@kp.org
authors.forename: Gavin F
authors.initials: GF
authors.lastname: Jacobson
authors.forename: Amy M
authors.initials: AM
authors.lastname: Autry
authors.forename: Tifany L
authors.initials: TL
authors.lastname: Somer-Shely
authors.forename: Kevin L
authors.initials: KL
authors.lastname: Pieper
authors.forename: Russell S
authors.initials: RS
authors.lastname: Kirby
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000453:epidemiology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000453:epidemiology / Q000382:microbiology*; D011247:Pregnancy; D016036:Seroepidemiologic Studies; D013383:Suburban Population; D014481:United States / Q000453:epidemiology; D014505:Urban Population
chemical_list: D000907:Antibodies, Bacterial