title: Susceptibility and biomarker knowledge for improvement of environmental health.
abstract: At the international level, environmental health problems are usually most serious in countries that have the least resources to deal with the problems. Therefore, international efforts have been initiated to achieve equitable environmental health globally. One approach is to conduct international collaborative studies. This approach has been successful in the building of scientific infrastructure in these countries so that they can address their own environmental health concerns and to sustain the environmental health programs. Using liver and oral cancers as models for discussion, examples of success in the identification of etiology and the mechanisms for the diseases are provided. For example, biomarkers are used to provide early warning signals for the disease. In addition, the application of the collected information for developing disease prevention and intervention programs is presented. Expertise in genetic susceptibility is used to provide a more precise understanding of the cancer process. With the precise knowledge, the information can potentially be used to screen for high-risk individuals and to develop "designer" intervention procedures against specific biochemical defects. Success in disease prevention is dependent upon multidisciplinary collaborations at the local and international levels.
authors.affiliation: Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas 77555-1110, USA.
authors.forename: Salama A
authors.initials: SA
authors.lastname: Salama
authors.forename: William W
authors.initials: WW
authors.lastname: Au
mesh_terms: D016604:Aflatoxin B1 / Q000235:genetics; D001231:Aspergillus flavus / Q000472:pathogenicity; D015415:Biomarkers; D004198:Disease Susceptibility / Q000453:epidemiology; D004782:Environmental Health; D014943:Global Health; D006801:Humans; D007391:International Cooperation; D008113:Liver Neoplasms / Q000209:etiology* / Q000517:prevention & control; D009062:Mouth Neoplasms / Q000209:etiology* / Q000517:prevention & control
chemical_list: D015415:Biomarkers; D016604:Aflatoxin B1