[The non-trauma fluorescence analysis of the porphyrin in the blood of human superficial skin tissue].
The porphyrin compound in human body mainly includes hemoglobin, protoheme, protoporphyrin, coproporphyrin, uroporphyrin and so on. As we know, the metabolism of the porphyrin in human body depends on the physical conditions. It was found that the relative content of protoporphyrin (PPIX) and carotenoid in blood varied with the developing of the malignant tumor. A system, including Ti: sapphire laser, optical fiber delivery system, fluorescence probe, spectrometer CCD and computer, has been developed to examine the porphyrin in human superficial skin tissue without trauma. It was shown that the fluorescence spectrum of the porphyrin obtained from the superficial skin tissue of human earlobe has the same feature as that from the aqueous solution with PP IX.
Meng
Ji-wu
JW
Department of Physics, Ocean University of China, Qingdao 266003, China.
Gu
Huai-min
HM
Zheng
Rong-er
RE
Xing
Da
D
Wang
Juan
J
Wang
Rong
R
Zhang
Yun-dong
YD
D014408:Biomarkers, Tumor / Q000097:blood*; D002338:Carotenoids / Q000097:blood; D003306:Coproporphyrins / Q000097:blood; D006801:Humans; D011166:Porphyrins / Q000097:blood*; D011524:Protoporphyrins / Q000097:blood; D012867:Skin / Q000098:blood supply* / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D014578:Uroporphyrins / Q000097:blood
D014408:Biomarkers, Tumor; D003306:Coproporphyrins; D011166:Porphyrins; D011524:Protoporphyrins; D014578:Uroporphyrins; D002338:Carotenoids