Shrinkage control: regulation of insulin-mediated growth by FOXO transcription factors.
The insulin signaling pathway regulates organismal growth in response to nutrient conditions by controlling a range of metabolic and biosynthetic processes. Recent studies in Drosophila have shown how transcriptional responses to reduced insulin and nutrient levels can act to inhibit growth.
Neufeld
Thomas P
TP
Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA. neufeld@med.umn.edu
D000818:Animals; D004330:Drosophila / Q000254:growth & development*; D029721:Drosophila Proteins / Q000502:physiology*; D051858:Forkhead Transcription Factors; D007328:Insulin / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
D029721:Drosophila Proteins; C477334:FOXO protein, Drosophila; D051858:Forkhead Transcription Factors; D007328:Insulin; D014157:Transcription Factors