Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests.
Mice from 8 to 21 inbred strains were tested for sensitivity to ethanol intoxication using a range of doses and three different measures: the screen test, the dowel test and a test of grip strength. Strains differed under nearly all conditions. For the dowel test, two dowel widths were employed, and mice were tested immediately or 30 min after ethanol. For the dowel and screen tests, low doses failed to affect some strains, and the highest doses failed to discriminate among mice, maximally affecting nearly all. For grip strength, a single ethanol dose was used, and mice of all strains were affected. Pharmacokinetic differences among strains were significant, but these could not account for strain differences in intoxication. For doses and test conditions in the middle range, there were only modest correlations among strain means within a test. In addition, genotypic correlations across tests were modest to quite low. These results suggest that different specific versions of a test reflect the influence of different genes, and that genetic influences on different tests were also distinct.
Crabbe
J C
JC
Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon, USA. crabbe@ohsu.edu
Cotnam
C J
CJ
Cameron
A J
AJ
Schlumbohm
J P
JP
Rhodes
J S
JS
Metten
P
P
Wahlsten
D
D
D000435:Alcoholic Intoxication / Q000235:genetics; D000818:Animals; D001259:Ataxia / Q000139:chemically induced / Q000235:genetics; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002492:Central Nervous System Depressants / Q000493:pharmacokinetics / Q000506:poisoning*; D000431:Ethanol / Q000493:pharmacokinetics / Q000506:poisoning*; D005838:Genotype; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity
D002492:Central Nervous System Depressants; D000431:Ethanol