title: Transport of trace elements in lenses of normal and hereditary cataract UPL rats.
abstract: The multitracer technique was applied to the determination of the uptake of trace elements in the lenses of normal and hereditary cataract UPL rats to investigate the transport mechanisms of trace elements during cataract development. Be, Na, Sc, V, Cr, Mn, Fe, Co, Zn, As, Se, Rb, Sr, Y, Zr, Tc, Ru and Rh accumulate in normal and UPL cataract rat lenses. The rates of uptake of trace elements differ among species and also differ between normal and UPL rat lenses. The uptakes of V and Sr are greater in normal rat lenses, while the uptakes of Mn and Co are greater in UPL rat lenses. High concentrations of Zn are transported into normal rat lenses in comparison with other elements. However, the uptake of Se was highest in the lenses of UPL cataract rats. In addition, the difference in Se uptake between the normal and UPL rat lenses was greatest among the tested trace elements. The present study suggests that the transport characteristics of trace elements are different in the lenses of normal and UPL cataract rats. The different transport characteristics of trace elements in the lenses of normal and UPL cataract rats, especially the higher accumulation of Se in UPL rat lenses, may be implicated in cataract development.
authors.affiliation: Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Kamishin'ei-cho, Niigata, 950-2081, Japan. nabe@niigata-pharm.ac.jp
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nabekura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Minami
authors.forename: Rieko
authors.initials: R
authors.lastname: Hirunuma
authors.forename: Shuichi
authors.initials: S
authors.lastname: Enomoto
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tomohiro
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Ito
authors.forename: Shuji
authors.initials: S
authors.lastname: Kitagawa
mesh_terms: D000818:Animals; D001692:Biological Transport; D002386:Cataract / Q000378:metabolism*; D004195:Disease Models, Animal; D015785:Eye Diseases, Hereditary / Q000378:metabolism*; D066298:In Vitro Techniques; D007908:Lens, Crystalline / Q000378:metabolism*; D019216:Metals, Heavy / Q000493:pharmacokinetics* / Q000633:toxicity; D011849:Radioactive Tracers; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019216:Metals, Heavy; D011849:Radioactive Tracers