Role of white matter lesions, cerebral atrophy, and APOE on cognition in older persons with and without dementia: the Cache County, Utah, study of memory and aging.
Neuropsychological, qualitative, and quantitative magnetic resonance imaging findings were examined in subjects with Alzheimer's disease (AD), non-AD dementia or mixed neuropsychiatric disorder, subjects characterized as mild/ambiguous, and controls, all with known apolipoprotein E (APOE) genotype. Neuropsychological tasks included an expanded Consortium to Establish a Registery for Alzheimer's Disease (J. T. Tschanz et al., 2000; K. A. Welsh, J. M. Hoffman, N. L. Earl, & M. W. Hanson 1994) battery and the Mini-Mental Status Examination (M. F. Folstein, S. E. Folstein, & P. R. McHugh, 1975). Periventricular white matter lesions were the most clinically salient, and generalized measures of cerebral atrophy were the most significant quantitative indicators. APOE genotype was unrelated to imaging or neuropsychological performance. Neuropsychological relationships with neuroimaging findings depend on the qualitative or quantitative method used.
Bigler
Erin D
ED
Department of Psychology, Brigham Young University, Provo, Utah 84602, USA. erin_bigler@byu.edu
Lowry
Christopher M
CM
Kerr
Burton
B
Tate
David F
DF
Hessel
Cory D
CD
Earl
Heath D
HD
Miller
Michael J
MJ
Rice
Sara A
SA
Smith
Kay H
KH
Tschanz
JoAnn T
JT
Welsh-Bohmer
Kathleen
K
Plassman
Brenda
B
Victoroff
Jeff
J
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D000544:Alzheimer Disease / Q000473:pathology; D001057:Apolipoproteins E / Q000235:genetics; D001284:Atrophy; D001369:Axons / Q000473:pathology*; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D002552:Cerebral Ventricles / Q000473:pathology; D003072:Cognition Disorders / Q000235:genetics / Q000473:pathology*; D003704:Dementia / Q000473:pathology; D005260:Female; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008569:Memory Disorders / Q000473:pathology; D009483:Neuropsychological Tests; D014589:Utah
D001057:Apolipoproteins E