title: Enhanced release from proactive interference in nonamnesic alcoholic individuals: implications for impaired associative binding.
abstract: Proactive interference (PI) occurs when previously learned information reduces the ability to acquire new, related information. Given that PI is modulated by the cholinergic system in rats (E. De Rosa & M. E. Hasselmo, 2000) and that chronic alcohol dependence disrupts cholinergic function in rats and humans, associative properties of PI in patients with alcoholism were examined. It was hypothesized that normal PI contingencies would be disrupted in alcoholic participants. When tested with a paired-associate simultaneous discrimination paradigm, analogous to that used in the rat model, alcoholic participants showed significantly less PI than controls yet performed comparably on a control response reversal task. The absence of PI in alcoholic participants may reflect impaired configural binding of paired-associate stimuli while sparing the elemental ability to process each stimulus component.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, USA. derosa@psych.utoronto.ca
authors.forename: Eve
authors.initials: E
authors.lastname: De Rosa
authors.forename: Edith V
authors.initials: EV
authors.lastname: Sullivan
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000328:Adult; D000437:Alcoholism / Q000523:psychology*; D001245:Association Learning; D016022:Case-Control Studies; D003118:Color Perception; D004193:Discrimination Learning; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011334:Proactive Inhibition; D016548:Prosencephalon / Q000378:metabolism / Q000503:physiopathology; D011597:Psychomotor Performance
chemical_list: D000109:Acetylcholine