Small dense LDL phenotype is associated with postprandial increases of large VLDL and remnant-like particles in patients with acute myocardial infarction.
BACKGROUND
The small dense low-density lipoprotein (LDL) phenotype (pattern B), high concentrations of remnant-like particles (RLPs), and postprandial lipemia are newly recognized risk factors for coronary heart disease (CHD). However, the associations of these lipoprotein abnormalities remain unclear. The aim of this study was to investigate the relationships among LDL phenotype, very-low-density lipoprotein (VLDL) subclasses, and postprandial lipoprotein metabolism in CHD patients.


METHODS
We performed an oral fat tolerance test in 32 patients with acute myocardial infarction and compared the following parameters between patients characterized by either large buoyant LDL (pattern A) versus pattern B: lipids and apolipoproteins (apo) in the plasma and Svedberg flotation rates (Sf) >400 (chylomicron), Sf 60-400 (large VLDL), and Sf 20-60 (small VLDL) fractions.


RESULTS
Fasting levels of triglyceride, RLP-cholesterol and RLP-triglyceride were slightly higher in the pattern B patients. Postprandial increases of RLP-cholesterol and the cholesterol and triglyceride of large VLDL fractions were significantly greater in the pattern B patients. The areas under the curves of cholesterol, triglyceride, and apo-B in large VLDL fractions were significantly higher in pattern B, while those in small VLDL were not. RLP-cholesterol and RLP-triglyceride in fasting and fed states correlated very highly with the corresponding cholesterol and triglyceride concentrations in large VLDL fractions.


CONCLUSIONS
These results suggest that postprandial increase of large VLDL fractions and RLPs contribute to the formation of small dense LDL in CHD patients.
Koba
Shinji
S
Third Department of Internal Medicine, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan. skoba@med.showa-u.ac.jp
Hirano
Tsutomu
T
Murayama
Satoru
S
Kotani
Tomomi
T
Tsunoda
Fumiyosi
F
Iso
Yoshitaka
Y
Ban
Yoshihisa
Y
Kondo
Takeshi
T
Suzuki
Hiroshi
H
Katagiri
Takashi
T
D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D001059:Apoproteins / Q000235:genetics / Q000378:metabolism; D019540:Area Under Curve; D015415:Biomarkers / Q000097:blood; D008076:Cholesterol, HDL / Q000235:genetics / Q000378:metabolism; D008078:Cholesterol, LDL / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D015243:Cholesterol, VLDL / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D005215:Fasting / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005838:Genotype; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000235:genetics / Q000378:metabolism; D007333:Insulin Resistance / Q000235:genetics; D007564:Japan; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics* / Q000628:therapy; D010316:Particle Size; D010343:Patient Admission; D010641:Phenotype; D019518:Postprandial Period / Q000235:genetics*; D012307:Risk Factors; D013223:Statistics as Topic; D013997:Time Factors; D014280:Triglycerides / Q000235:genetics / Q000378:metabolism
D001059:Apoproteins; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D007328:Insulin; D014280:Triglycerides