2-piperidin-4-yl-benzimidazoles with broad spectrum antibacterial activities.
A series of 2-piperidin-4-yl-benzimidazoles were synthesized and evaluated for antibacterial activities. Certain compounds inhibit bacterial growth with low micromolar minimal inhibitory concentration (MIC). These benzimidazoles are effective against both Gram-positive and Gram-negative bacteria of clinical importance, particularly enterococci, and represent a new class of potential antibacterial agents.
He
Yun
Y
Ibis Therapeutics, A Division of Isis Pharmaceuticals, Inc., 2292 Faraday Avenue, Carlsbad, CA 92008, USA. yhe@gnf.org
Wu
Baogen
B
Yang
Jun
J
Robinson
Dale
D
Risen
Lisa
L
Ranken
Ray
R
Blyn
Lawrence
L
Sheng
Suzie
S
Swayze
Eric E
EE
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001562:Benzimidazoles / Q000737:chemistry* / Q000494:pharmacology; D016983:Enterococcus / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests / Q000379:methods; D010880:Piperidines / Q000737:chemistry* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001562:Benzimidazoles; D010880:Piperidines