title: Treadmill exercise suppresses ischemia-induced increment in apoptosis and cell proliferation in hippocampal dentate gyrus of gerbils.
abstract: Cerebral ischemia resulting from transient or permanent occlusion of cerebral arteries leads to neuronal cell death and eventually causes neurological impairments. In the present study, the effects of treadmill exercise on apoptosis and cell proliferation in the hippocampal dentate gyrus following transient global ischemia in gerbils were investigated using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay and immunohistochemistry for caspase-3 and 5-bromo-2'-deoxyuridine (BrdU). It was shown that apoptotic cell death and cell proliferation in the hippocampal dentate gyrus were significantly increased following transient global ischemia in gerbils and that treadmill exercise suppressed the ischemia-induced increase in apoptosis and cell proliferation in the dentate gyrus. The present results suggest that treadmill exercise may protect cells from apoptotic death and aid in recovery from the central nervous system sequelae following stroke.
authors.affiliation: Research Institute of Sports Science, Korea University, #1 5-Ka Anam-dong, Sungbuk-ku, Seoul 136-701 South Korea.
authors.forename: Myoung-Hwa
authors.initials: MH
authors.lastname: Lee
authors.forename: Hong
authors.initials: H
authors.lastname: Kim
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Kim
authors.forename: Taeck-Hyun
authors.initials: TH
authors.lastname: Lee
authors.forename: Baek-Vin
authors.initials: BV
authors.lastname: Lim
authors.forename: Hyun-Kyung
authors.initials: HK
authors.lastname: Chang
authors.forename: Mi-Hyeon
authors.initials: MH
authors.lastname: Jang
authors.forename: Min-Chul
authors.initials: MC
authors.lastname: Shin
authors.forename: Mal-Soon
authors.initials: MS
authors.lastname: Shin
authors.forename: Chang-Ju
authors.initials: CJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D018891:Dentate Gyrus / Q000473:pathology*; D004195:Disease Models, Animal; D005849:Gerbillinae; D020287:In Situ Nick-End Labeling; D002546:Ischemic Attack, Transient / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D010805:Physical Conditioning, Animal; D005082:Physical Exertion