[Is levosimendan an inoprotective drug in patients with acute coronary syndrome undergoing surgical revascularization?].
Levosimendan, is a new calcium sensitiser with 2 major effects. First, levosimendan acts as a positive inotropic agent by binding calcium dependently to cardiac troponin C. Second, levosimendan activates adenosine triphosphate-regulated potassium (K (ATP)) channels. Thus it has vasodilatory properties and cardioprotective effects at a dose enhancing myocardial contractility. These unique properties of levosimendan might be of great advantage in patients with myocardial ischemia simultaneously requiring inotropic support. The concept of perioperative inoprotection is presented in 6 patients with acute ischemia undergoing emergent cardiac surgery.
Lehmann
A
A
Klinik für Anästhesiologie und Operative Intensivmedizin, Klinikum der Stadt Ludwigshafen, Germany. Dr. A.Lehmann@web.de
Boldt
J
J
Lang
J
J
Isgro
F
F
Blome
M
M
D018528:ATP-Binding Cassette Transporters; D000328:Adult; D000368:Aged; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D003327:Coronary Disease / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006835:Hydrazones / Q000627:therapeutic use*; D054086:KATP Channels; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000601:surgery; D009203:Myocardial Infarction / Q000150:complications / Q000601:surgery; D009204:Myocardial Revascularization / Q000009:adverse effects*; D015221:Potassium Channels / Q000819:agonists; D024661:Potassium Channels, Inwardly Rectifying; D011724:Pyridazines / Q000627:therapeutic use*; D000077464:Simendan
D018528:ATP-Binding Cassette Transporters; D002316:Cardiotonic Agents; D006835:Hydrazones; D054086:KATP Channels; D015221:Potassium Channels; D024661:Potassium Channels, Inwardly Rectifying; D011724:Pyridazines; C092520:uK-ATP-1 potassium channel; D000077464:Simendan
Wirkt Levosimendan bei der operativen Versorgung des akuten Koronarsyndroms inoprotektiv?