title: [Transitional cell carcinoma of the urinary bladder accompanied by signet-ring cell carcinoma: a case report].
abstract: A 58-year-old man visited our clinic with complaints of gross hematuria and pollakisuria. Cystoscopic examination revealed multiple non-papillary broad based tumors and reddish unstable mucosa in the bladder. The pathological specimen of the transurethral biopsy of the tumors showed signet-ring cell carcinoma predominantly and adenocarcinoma transforming into signet-ring cell carcinoma partially. A total cystectomy with ileal conduit urinary diversion was performed. The histopathological finding of the radical cystectomy specimen was grade 3 transitional cell carcinoma accompanied by adenocarcinoma. These findings suggest that the adenomatous metaplasia of transitional cell carcinoma in the bladder could differentiate into signet-ring cell carcinoma.
authors.affiliation: Department of Urology, Kanto Central Hospital.
authors.forename: Zen
authors.initials: Z
authors.lastname: Ozeki
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Tatuya
authors.initials: T
authors.lastname: Machida
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ishizaka
authors.forename: Teruaki
authors.initials: T
authors.lastname: Oka
mesh_terms: D018279:Carcinoma, Signet Ring Cell / Q000473:pathology* / Q000601:surgery; D002295:Carcinoma, Transitional Cell / Q000473:pathology* / Q000601:surgery; D015653:Cystectomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000601:surgery