Preparation of (5 alpha,13 alpha)-D-azasteroids as key precursors of a new family of potential GABAA receptor modulators.
Three groups of (5 alpha,13 alpha)-D-azasteroids, (5 alpha,13 alpha)-3-hydroxy-17a-aza-D-homoandrostans (12), (5 alpha,13 alpha)-3-hydroxy-17-aza-D-homoandrostans (15), and (5 alpha,13 alpha)-3-hydroxy-17-azaandrostans (17), were designed and synthesized as key precursors for the further preparation of a new family of potential GABAA receptor modulators from commercially available natural steroids (5 alpha)-3-hydroxyandrostane-17-ones (7).
Wang
Cunde
C
Department of Chemistry, Nanjing University, Nanjing 210093, PR China.
Wang
Shaozhong
S
Xu
Yingju
Y
Hu
Yuefei
Y
Hu
Hongwen
H
D000777:Anesthetics / Q000138:chemical synthesis; D001378:Azasteroids / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000777:Anesthetics; D001378:Azasteroids; D058785:GABA-A Receptor Agonists; D058787:GABA-A Receptor Antagonists