Interaction of some esters of 2-, 3-, 4-alkoxyphenylcarbamic acids with surface-bound DNA at a dsDNA modified electrode. Study of local anaesthetics: Part 164.
An interaction of some derivatives of 2-, 3-, 4-alkoxyphenylcarbamic acids with dsDNA was investigated using the anodic voltammetric signal at a DNA-based electrochemical biosensor. Significant, however, reversible association was found, particularly in weak acidic and neutral solution where the protonated forms of the drug molecules occur which are electrostatically bound to the negatively charged DNA backbone. Total drug liberation from the DNA layer within 1 min. was observed in blank buffer solution without drug molecules.
Vanícková
M
M
Department of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Bratislava, Slovakia.
Labuda
J
J
Lehotay
J
J
Cizmárik
J
J
D000473:Alkanes / Q000737:chemistry*; D015374:Biosensing Techniques; D002021:Buffers; D002219:Carbamates / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000187:drug effects*; D004563:Electrochemistry; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents
D000473:Alkanes; D002021:Buffers; D002219:Carbamates; D007202:Indicators and Reagents; D004247:DNA