title: Selective effect of oleamide, an endogenous sleep-inducing lipid amide, on pentylenetetrazole-induced seizures in mice.
abstract: The anti-seizure effect of oleamide, an endogenous sleep-inducing fatty acid amide, was studied in mice. Oleamide, in the dose range 43.7-700.0 mg kg(-1), significantly and dose-dependently inhibited the seizures induced by pentylenetetrazole. However, oleamide showed no inhibitory action on the seizures induced by picrotoxin, strychnine, caffeine or semicarbazide. These results provide the first evidence for the anti-seizure effect of oleamide, and suggest that this effect may be selective to the seizure model induced by pentylenetetrazole.
authors.affiliation: Department of Pharmacology, Shenyang Pharmaceutical University, 110016 Shenyang, People's Republic of China. wuchunf@21cn.com
authors.forename: Chun-Fu
authors.initials: CF
authors.lastname: Wu
authors.forename: Chun-Li
authors.initials: CL
authors.lastname: Li
authors.forename: Hong-Rui
authors.initials: HR
authors.lastname: Song
authors.forename: Hua-Feng
authors.initials: HF
authors.lastname: Zhang
authors.forename: Jing-Yu
authors.initials: JY
authors.lastname: Yang
authors.forename: Yu-Ling
authors.initials: YL
authors.lastname: Wang
mesh_terms: D000818:Animals; D003292:Convulsants / Q000009:adverse effects*; D003975:Diazepam / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009829:Oleic Acids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D010433:Pentylenetetrazole / Q000009:adverse effects*; D012640:Seizures / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control*; D012890:Sleep / Q000187:drug effects / Q000502:physiology
chemical_list: D003292:Convulsants; D009829:Oleic Acids; C029407:oleylamide; D003975:Diazepam; D010433:Pentylenetetrazole