Connecting the dots for mechanochemical transduction in muscle.
One of the most impressive adaptive physiological responses is that of muscle to high intensity exercise, as espoused by power athletes and body builders, which results in increases in muscle mass. Athletics and vanity aside, there are many reasons for wishing to know more about the mechanisms underlying this hypertrophy, not least being the possibility of pharmacologically enhancing it in sarcopenia. The work of Bolster and colleagues in this issue of The Journal of Physiology brings us nearer to a complete understanding of the relevant subcellular events occurring in response to resistance exercise by providing a time course of activities of signalling proteins involved in regulating the translational phase of muscle protein synthesis.
Rennie
Michael J
MJ
Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee DD1 4HN, UK.
Wackerhage
Henning
H
D000818:Animals; D001696:Biomechanical Phenomena; D018482:Muscle, Skeletal / Q000201:enzymology / Q000502:physiology*; D020652:Peptide Elongation Factor 2 / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D038762:Ribosomal Protein S6 Kinases, 70-kDa / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D020652:Peptide Elongation Factor 2; D019869:Phosphatidylinositol 3-Kinases; D038762:Ribosomal Protein S6 Kinases, 70-kDa; C448959:ribosomal protein S6 kinase, 70kD, polypeptide 2