title: Cumulative irritancy comparison of adapalene gel 0.1% versus other retinoid products when applied in combination with topical antimicrobial agents.
abstract: This randomized, investigator-blinded study evaluated the level of skin tolerance to adapalene gel 0.1%, tretinoin cream 0.025%, or tretinoin microsphere gel 0.1% when applied in combination with clindamycin phosphate lotion 1%, erythromycin gel 2%, benzoyl peroxide gel 5%, or erythromycin-benzoyl peroxide gel. A total of 37 subjects underwent daily application of the topical antimicrobial and retinoid products to sites on their upper back under protective patches for approximately 16 hours each day; Friday patches were left in place over the weekend. Testing continued daily for 3 weeks or until discontinuation caused by a severe adverse reaction to any of the test products or to the patch. Adapalene gel 0.1% demonstrated statistically significantly (P <.001) less irritation after repeated application under occlusive conditions than tretinoin cream 0.025% or tretinoin microsphere gel 0.1%. Moreover, the application of adapalene gel 0.1% under these conditions, concomitantly with various antimicrobial agents, was safe and well tolerated in this subject population. In view of its low irritation potential and its efficacy, adapalene gel 0.1%, in combination with antimicrobial agents should be considered for the treatment of acne vulgaris.
authors.affiliation: TKL Research Inc.
authors.forename: Barbara
authors.initials: B
authors.lastname: Brand
authors.forename: Richard
authors.initials: R
authors.lastname: Gilbert
authors.forename: Michael D
authors.initials: MD
authors.lastname: Baker
authors.forename: Michel
authors.initials: M
authors.lastname: Poncet
authors.forename: Alan
authors.initials: A
authors.lastname: Greenspan
authors.forename: Kathleen
authors.initials: K
authors.lastname: Georgeian
authors.forename: Andrew-Marc
authors.initials: AM
authors.lastname: Soloff
mesh_terms: D000152:Acne Vulgaris / Q000175:diagnosis / Q000188:drug therapy*; D000068816:Adapalene; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D020714:Maximum Tolerated Dose; D008875:Middle Aged; D009281:Naphthalenes / Q000008:administration & dosage / Q000009:adverse effects*; D012176:Retinoids / Q000008:administration & dosage / Q000009:adverse effects*; D018570:Risk Assessment; D016037:Single-Blind Method; D023422:Skin Irritancy Tests
chemical_list: D000900:Anti-Bacterial Agents; D009281:Naphthalenes; D012176:Retinoids; D000068816:Adapalene