Enhanced activation of CD83-positive T cells.
CD83 is a marker molecule for mature dendritic cells (DCs) but is also substantially expressed on activated T cells in humans and mice. Its function is unknown, but CD83 knockout mice show an impaired thymic maturation of CD4-positive cells and soluble CD83 inhibits partially antigen-specific responses in vitro pointing to a role of CD83 in the immune system. Here we show that CD83-positive T cells produce strongly increased amounts of interferon-gamma and interleukin-2. In contrast, constitutive expression of CD83 on DCs alters neither the activation of DCs following addition of lipopolysaccharide nor the ability to present antigenic peptides. Thus, the expression of CD83 on T cells has direct functional consequences for tuning the activation threshold.
Wolenski
M
M
Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany.
Cramer
S O
SO
Ehrlich
S
S
Steeg
C
C
Fleischer
B
B
von Bonin
A
A
D000818:Animals; D015703:Antigens, CD; D002454:Cell Differentiation / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D004527:Egg Proteins / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007136:Immunoglobulins / Q000096:biosynthesis / Q000276:immunology*; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology; D007376:Interleukin-2 / Q000096:biosynthesis / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010047:Ovalbumin / Q000276:immunology; D010446:Peptide Fragments; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D000097802:CD83 Antigen
D015703:Antigens, CD; D004527:Egg Proteins; D007136:Immunoglobulins; D007371:Interferon-gamma; D007376:Interleukin-2; D008562:Membrane Glycoproteins; D010047:Ovalbumin; D010446:Peptide Fragments; D000097802:CD83 Antigen; C110366:OVA-8