title: The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-x(L) and Bcl-x(S)) that encode apoptotic regulatory proteins.
abstract: The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-x(L) transcript versus the Bcl-x(S) transcript in Neuro-2A cells. Bcl-x(L) encodes an antiapoptotic protein, whereas Bcl-x(S) encodes a proapoptotic protein. Promoting the accumulation of Bcl-x(L) in neurons may inhibit apoptosis, thus enhancing the latency-reactivation cycle.
authors.affiliation: Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska 68583-0905, USA.
authors.forename: Weiping
authors.initials: W
authors.lastname: Peng
authors.forename: Gail
authors.initials: G
authors.lastname: Henderson
authors.forename: Guey-Chuen
authors.initials: GC
authors.lastname: Perng
authors.forename: Anthony B
authors.initials: AB
authors.lastname: Nesburn
authors.forename: Steven L
authors.initials: SL
authors.lastname: Wechsler
authors.forename: Clinton
authors.initials: C
authors.lastname: Jones
mesh_terms: D017209:Apoptosis; D018259:Herpesvirus 1, Human / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000235:genetics*; D017735:Virus Latency; D051020:bcl-X Protein
chemical_list: C494811:BCL2L1 protein, human; D035683:MicroRNAs; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger; D014764:Viral Proteins; D051020:bcl-X Protein; C477253:latency associated transcript, herpes simplex virus-1