[Effects of aminoglycoside antibiotics on various structures of the acoustic analyzer].
Aminoglycoside antibiotics decrease the microphone potential amplitude and the auditory nerve potential in response to acoustic stimulation. These drugs suppress the bioelectrical activity of medulla, cerebral cortex, and olivo-cochlear efferent system. The experiments on freely moving cats showed that cortical response to electric stimulation of thalamocortical fibers originating from medial geniculate body are more sensitive to aminoglycoside antibiotics than the microphone potential and the auditory nerve potential.
Fisenko
V P
VP
Department of Pharmacology, Sechenov Medical Academy, ul. Bol'shaya Pirogovskaya 2/6, Moscow, 119881 Russia.
D000200:Action Potentials / Q000187:drug effects; D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001307:Auditory Perception / Q000187:drug effects*; D001309:Auditory Threshold / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000187:drug effects* / Q000503:physiopathology; D003055:Cochlear Microphonic Potentials / Q000187:drug effects; D007758:Ear, Inner / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D006309:Hearing / Q000187:drug effects*; D034381:Hearing Loss / Q000139:chemically induced / Q000503:physiopathology; D006801:Humans
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents
Vliianie antibiotikov-aminoglikozidov na raznye struktury slukhovogo analizatora.