title: Expression of BEN, a member of TFII-I family of transcription factors, during mouse pre- and postimplantation development.
abstract: BEN is a member of the TFII-I family of transcription factors, characterized by the presence of multiple helix-loop-helix repeat domains. Our immunohistochemical analysis demonstrated broad and extensive expression of BEN during mouse pre- and postimplantation development, with highest levels occurring during early to midgestation. Maternally expressed BEN is present in both the cytoplasm and nuclei of the zygote; however, it retains a predominantly nuclear localization between the two-cell stage of development and early blastocyst stages. This nuclear expression is observed in most tissues throughout development. Although, it is interesting to note that at E4.5-6.5, during early gastrulation stage, BEN is localized in the cytoplasm. At later stages, BEN retains an extensive expression pattern in a variety of developing systems implicating its involvement in tissue development and organogenesis.
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney avenue, New Haven, CT 06520, USA. bayarsaihan@yale.edu
authors.forename: Dashzeveg
authors.initials: D
authors.lastname: Bayarsaihan
authors.forename: Natalia
authors.initials: N
authors.lastname: Bitchevaia
authors.forename: Badam
authors.initials: B
authors.lastname: Enkhmandakh
authors.forename: Maria Isabel
authors.initials: MI
authors.lastname: Tussie-Luna
authors.forename: James F
authors.initials: JF
authors.lastname: Leckman
authors.forename: Ananda
authors.initials: A
authors.lastname: Roy
authors.forename: Frank
authors.initials: F
authors.lastname: Ruddle
mesh_terms: D020410:Activated-Leukocyte Cell Adhesion Molecule / Q000378:metabolism*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D047108:Embryonic Development; D005260:Female; D018257:Helix-Loop-Helix Motifs; D007150:Immunohistochemistry; D051379:Mice / Q000196:embryology* / Q000378:metabolism*; D009928:Organ Specificity; D011247:Pregnancy; D019473:Transcription Factors, TFII / Q000378:metabolism
chemical_list: D020410:Activated-Leukocyte Cell Adhesion Molecule; D019473:Transcription Factors, TFII