CD4+ T cell matters in tumor immunity.
CD4+ T cells have been shown to be able to affect tumor growth through both direct and indirect means. In addition, a requirement has been demonstrated for CD4+ T cells in the regulation and induction of T cell memory, and CD4+ suppressor T cells have been identified, stressing a role for CD4+ T cells in the induction and maintenance of antitumor immune responses. A review of the involvement of CD4+ T cells at different stages of tumor immunity is provided, and based on these data we discuss how CD4+ T cell response induction could be incorporated into tumor immunotherapy strategies.
Velders
Markwin P
MP
Cancer Immunology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, Illinois 60153, USA.
Markiewicz
Mary A
MA
Eiben
Gretchen L
GL
Kast
W Martin
WM
D000912:Antibodies, Neoplasm / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D019496:Cancer Vaccines / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology; D009369:Neoplasms / Q000276:immunology*; D009389:Neovascularization, Pathologic / Q000276:immunology
D000912:Antibodies, Neoplasm; D019496:Cancer Vaccines; D007371:Interferon-gamma