title: Stress responses after treatment of hypercholesterolaemia with simvastatin.
abstract: In order to determine whether treatment of hyperlipidaemia with simvastatin impairs exercise stress responses and so may contribute to an excess of suicides and violent deaths, the effects of simvastatin 20 mg daily and placebo on exercise physiology were compared in 19 patients. After 6 weeks of treatment there was no evidence of reduced exercise capacity, or of reduced cortisol or catecholamine responses. It is concluded that treatment of hyperlipidaemia with an inhibitor of HMG-CoA reductase does not significantly modify stress responses, and so the explanation for a possible increase in non-cardiac mortality must be sought elsewhere.
authors.affiliation: Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland.
authors.forename: A M
authors.initials: AM
authors.lastname: Nugent
authors.forename: D
authors.initials: D
authors.lastname: Neely
authors.forename: I
authors.initials: I
authors.lastname: Young
authors.forename: I
authors.initials: I
authors.lastname: McDowell
authors.forename: M
authors.initials: M
authors.lastname: O'Kane
authors.forename: N
authors.initials: N
authors.lastname: Bell
authors.forename: C F
authors.initials: CF
authors.lastname: Stanford
authors.forename: D P
authors.initials: DP
authors.lastname: Nicholls
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D019821:Simvastatin / Q000627:therapeutic use*; D013312:Stress, Physiological / Q000209:etiology*
chemical_list: D000924:Anticholesteremic Agents; D000324:Adrenocorticotropic Hormone; D019821:Simvastatin