Effect of medroxyprogesterone acetate on the efficiency of an oral protein-rich nutritional support in HIV-infected patients.
We have examined the effect of a medroxyprogesterone therapy in HIV-infected patients under appropriate nutrition for anabolism. The experiments were performed on 12 men (mean age 40 y), HIV seropositive but free of any clinically active opportunistic infection for at least one month. The patients underwent a 2-week baseline diet period (1.2 g protein x kg(-1) body weight (BW) x d(-1)) and then a 5-week experimental period with again the baseline diet in conjunction with supplements including Tonexis HP (0.7 g protein x kg(-1) BW) x d(-1)), L-threonine (0.018 g x kg(-1) BW x d(-1)) and L-methionine (0.013 g x kg(-1) BW x d(-1)). Indeed HIV-infected patients showed deficiencies in these amino acids. They were randomly divided into groups I and II under double-blinded condition. Group II was given medroxyprogesterone acetate (0.4 g x d(-1)) during the last 3 weeks whereas group I received a placebo. All the patients significantly increased their body weight (P < 0.05) during the experimental periods. Those under medroxyprogesterone tended to show a higher but not significant weight gain (+3.1 +/- 1.0 kg in group II and +1.9 +/- 0.3 kg in group I). Blood free amino acids were used as rough indicators of amino acid utilization and were analyzed prior and during acute 150 min intravenous infusion of a complete glucose-amino acid mixture. This test was done before and at the end of the experimental periods. Basal essential blood free amino acids were similar in the two groups and did not change during the experimental period. Most essential amino acids increased following glucose-amino acid infusions. The incremental increase was of less magnitude after the experimental period than before when medroxyprogesterone was present (P < 0.05 for valine, leucine, lysine, threonine and methionine). This was not the case in the absence of the hormone. We concluded that medroxyprogesterone might improve the efficacy of an oral protein-rich nutritional support in HIV-infected patients.
Rochon
Cécile
C
Unité de Nutrition et Métabolisme Protéique, INRA, Centre de Clermont-Ferrand-Theix, 63122 Saint-Genès-Champanelle, France.
Prod'homme
Magali
M
Laurichesse
Henri
H
Tauveron
Igor
I
Balage
Michèle
M
Gourdon
Florence
F
Baud
Olivier
O
Jacomet
Christine
C
Jouvency
Sylvie
S
Bayle
Gérard
G
Champredon
Claude
C
Thieblot
Philippe
P
Beytout
Jean
J
Grizard
Jean
J
D000328:Adult; D000596:Amino Acids / Q000008:administration & dosage / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D004044:Dietary Proteins / Q000008:administration & dosage*; D004311:Double-Blind Method; D005947:Glucose / Q000008:administration & dosage; D015658:HIV Infections / Q000628:therapy*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D017258:Medroxyprogesterone Acetate / Q000627:therapeutic use*; D018529:Nutritional Support; D010919:Placebos; D014508:Urea / Q000097:blood; D015430:Weight Gain
D000596:Amino Acids; D001786:Blood Glucose; D001798:Blood Proteins; D004044:Dietary Proteins; D007328:Insulin; D010919:Placebos; D014508:Urea; D017258:Medroxyprogesterone Acetate; D005947:Glucose