title: Persistent minor smear abnormalities: is large loop excision of the transformation zone (LLETZ) the solution?
abstract: This prospective observational study was carried out to evaluate the efficacy of large loop excision of the transformation zone (LLETZ) as a management strategy for women with four or more smears showing borderline changes or mild dyskaryosis. A total of 102 women with four or more smears showing minor abnormalities and no colposcopic evidence of high-grade disease opted to undergo LLETZ in preference to continued cytological surveillance. Histology of the LLETZ specimens showed 11 cases of CIN2/3, one CGIN, 32 CIN1 and 10 HPV changes. In 97 of the 102 (95%) women, the follow-up cervical smear reverted to negative.
authors.affiliation: Department of Women's Health, Whittington Hospital, London, UK. pisal@dr.com
authors.forename: N
authors.initials: N
authors.lastname: Pisal
authors.forename: M
authors.initials: M
authors.lastname: Sindos
authors.forename: M E
authors.initials: ME
authors.lastname: Mansell
authors.forename: Theresa
authors.initials: T
authors.lastname: Freeman-Wang
authors.forename: A
authors.initials: A
authors.lastname: Singer
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*