Immunotoxin therapy for CNS tumor.
Surgery, chemotherapy, and radiation therapy have become standard of practice in treating malignant brain tumors. Unfortunately, the prognosis of these malignant tumors still remains poor. Immunotoxins are a relatively new adjuvant treatment for brain tumors. Within the last few years an increased amount of clinically-oriented research involving immunotoxins has been published. This has led to numerous clinical trials which although encouraging have not yet born out the "magic bullet" concept envisioned for immunotoxins. In this review article the history, design, toxicity, and pharmokinetics of immunotoxins will be discussed in detail.
Rustamzadeh
Edward
E
Department of Neurosurgery, Graduate School, University of Minnesota, Minneapolis, MN, USA. erusta@hotmail.com
Low
Walter C
WC
Vallera
Daniel A
DA
Hall
Walter A
WA
D000818:Animals; D000941:Antigens / Q000378:metabolism; D016543:Central Nervous System Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D000922:Immunotoxins / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D015552:Injections, Intralesional; D007275:Injections, Intravenous; D007278:Injections, Spinal; D011956:Receptors, Cell Surface / Q000378:metabolism
D000941:Antigens; D000922:Immunotoxins; D011956:Receptors, Cell Surface