title: Ultrastructural findings in metastatic bronchioloalveolar carcinoma.
abstract: This study was prompted by the recent revision of the definition of bronchioloalveolar carcinoma (BAC) that defines BAC, light microscopically, as a non-invasive carcinoma. Doubt has been raised whether BACs retain certain specific microscopic features after becoming invasive or metastatic. We studied 7 cases of metastatic, non-mucinous BAC by electron microscopy. Of these cases, 5 showed Clara cell granules and 1 revealed lamellar bodies. The remaining case did not show ultrastructural features of BAC. These findings suggest that most BACs retain some of their ultrastructural features after becoming metastatic neoplasms.
authors.affiliation: Department of Pathology, North Shore University Hospital, Manhasset, New York, USA.
authors.forename: Mary Aldrene L
authors.initials: MA
authors.lastname: Tan
authors.forename: Saul
authors.initials: S
authors.lastname: Teichberg
authors.forename: Beth
authors.initials: B
authors.lastname: Roberts
authors.forename: Steven I
authors.initials: SI
authors.lastname: Hajdu
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000737:chemistry / Q000556:secondary / Q000648:ultrastructure*; D000328:Adult; D000368:Aged; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000032:analysis*; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011506:Proteins / Q000032:analysis*; D014598:Uteroglobin
chemical_list: D007797:Laminin; D011506:Proteins; C556389:SCGB1A1 protein, human; D014598:Uteroglobin