title: Role of follicle-stimulating hormone receptor Ser680Asn polymorphism in the efficacy of follicle-stimulating hormone.
abstract: OBJECTIVE
  To evaluate the association between FSH efficacy and FSHR alleles.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  University-based fertility unit and a private center for biomedical research.
  
  
  METHODS
  One hundred two women with ovarian function who were undergoing controlled ovarian stimulation (COS). Women were categorized as poor responders (< or =3 ovarian follicles at the end of the cycle) or normal responders (>3 follicles).
  
  
  METHODS
  Daily administration of exogenous FSH.
  
  
  METHODS
  Number of good or poor responders.
  
  
  RESULTS
  The allele frequency and genotype distribution of the Ser680Asn marker differed significantly between groups. Cycle cancellations were increased (21%) among women who were homozygous for Ser680 compared with Ser/Asn and Asn/Asn patients, and 36% of poor-responders were homozygous for Ser680.
  
  
  CONCLUSIONS
  The results support a role for FSHR gene in COS outcome. However, the weight of this factor is probably low. The Ser680 allele may act in concert with other environmental and genetic factors that contribute to FSH efficacy.
authors.affiliation: Unidad de Reproducción Humana Asistida, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: de Castro
authors.forename: Rocío
authors.initials: R
authors.lastname: Ruiz
authors.forename: Luis
authors.initials: L
authors.lastname: Montoro
authors.forename: Dámaso
authors.initials: D
authors.lastname: Pérez-Hernández
authors.forename: Elisa
authors.initials: E
authors.lastname: Sánchez-Casas Padilla
authors.forename: Luis M
authors.initials: LM
authors.lastname: Real
authors.forename: Agustín
authors.initials: A
authors.lastname: Ruiz
mesh_terms: D000328:Adult; D000483:Alleles; D000595:Amino Acid Sequence / Q000235:genetics; D001216:Asparagine; D004334:Drug Administration Schedule; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D005787:Gene Frequency; D005819:Genetic Markers; D006720:Homozygote; D006801:Humans; D010062:Ovulation Induction; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000502:physiology*; D011962:Receptors, FSH / Q000235:genetics*; D011994:Recombinant Proteins / Q000008:administration & dosage; D012189:Retrospective Studies; D012694:Serine; D016896:Treatment Outcome
chemical_list: D005819:Genetic Markers; D011962:Receptors, FSH; D011994:Recombinant Proteins; D012694:Serine; D001216:Asparagine; D005640:Follicle Stimulating Hormone