Disuse atrophy alterations in normal and low temperature environments during hindlimb unloading in Syrian hamsters.
This study examined whether a hypothermic environment reduces experimentally-induced atrophy of skeletal muscle, as judged by histochemical findings. The hind limbs of hamsters in a hypothermic group were suspended and flexed into plantar positions at the ankle joint, and housed for one week at 8 to 12 degree celsius in a temperature-controlled room, while the normothermic group was housed at 23 to 25 degree celsius. Hypothermia did not significantly alter the average caloric intake, and the animals from the hypothermic group lost a significant amount of body weight when compared with the normothermic group. The hypothermic group retained more muscle wet-weight and myofibers cross-sectional area in the soleus and gastrocnemius muscles compared with the normothermic group. Our results indicate that a hypothermic environment inhibits short-term muscle atrophy. This inhibition may be caused by the increased caloric intake combined with a state similar to hibernation in low-temperature environments.
Nagano
Kagano
K
Department of Pharmacotherapy, Graduate School of Medical Sciences, Hiroshima University, Hiroshima 734-8551, Japan. nagano@hiroshima-u.ac.jp
Kajihara
Hiroki
H
Suzaki
Etuko
E
Suzuto
Masashi
M
Kataoka
Katsuko
K
Yoshii
Michiko
M
Ozawa
Koichiro
K
D000818:Animals; D006224:Cricetinae; D005121:Extremities; D019417:Hindlimb Suspension / Q000502:physiology; D007036:Hypothermia, Induced; D008647:Mesocricetus; D020966:Muscular Disorders, Atrophic / Q000503:physiopathology*; D013696:Temperature