title: Dendritic cells as inducers of antimicrobial immunity in vivo.
abstract: Models of infection have provided important insight into the function of dendritic cells (DC) in vivo. Several microbial products induce DC maturation via Toll-like receptors, a process that is crucial for the ability of DC to initiate adaptive immune responses. Splenic DC have also been shown to produce IL-12 during infection in vivo. This DC-derived IL-12 might be important to skew T cell responses towards Th1. Microbial infections also induce changes in the DC populations of lymphoid organs, often in a subset-specific manner, manifested as an accumulation and redistribution of DC. Furthermore, data are emerging pointing at an absolute requirement of DC in priming of naïve T cells in vivo.
authors.affiliation: Department of Clinical Immunology, Göteborg University, Sweden.
authors.forename: Malin
authors.initials: M
authors.lastname: Sundquist
authors.forename: Cecilia
authors.initials: C
authors.lastname: Johansson
authors.forename: Mary Jo
authors.initials: MJ
authors.lastname: Wick
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D056890:Eukaryota / Q000276:immunology; D006801:Humans; D018664:Interleukin-12 / Q000276:immunology; D007891:Leishmania / Q000276:immunology; D008087:Listeria / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology; D051379:Mice; D010272:Parasitic Diseases / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology; D012475:Salmonella / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D051193:Toll-Like Receptors
chemical_list: D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors; D018664:Interleukin-12