Nuclear microenvironments support physiological control of gene expression.
There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.
Stein
Gary S
GS
Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, 55 Lake Ave. North, Worcester, MA 01655, USA. gary.stein@umassmed.edu
Lian
Jane B
JB
Montecino
Martin
M
Stein
Janet L
JL
van Wijnen
André J
AJ
Javed
Amjad
A
Pratap
Jitesh
J
Choi
Je
J
Zaidi
S Kaleem
SK
Gutierrez
Soraya
S
Harrington
Kimberly
K
Shen
Jiali
J
Young
Daniel
D
Pockwinse
Shirwin
S
D002467:Cell Nucleus; D002843:Chromatin / Q000235:genetics; D005786:Gene Expression Regulation; D015530:Nuclear Matrix; D015675:Osteocalcin / Q000235:genetics / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
D002843:Chromatin; D014157:Transcription Factors; D015675:Osteocalcin