Association between genetic variation in the Y chromosome and hypertension in myocardial infarction patients.
A single nucleotide polymorphism (SNP) in chromosome Y has been associated with blood pressure. In men, the risk of suffering from cardiovascular diseases, including coronary artery disease, could be influenced by one or more loci on chromosome Y. We genotyped 208 men who had suffered an early episode of myocardial infarction (MI) (< or =55 years) and 178 healthy control men for two Y-polymorphisms (a HindIII polymorphism in an alphoid satellite in the centromeric non-recombining region and the -2627 T/C in the SRY gene). Frequencies were compared through a chi(2)-test. Frequencies for the two polymorphisms did not differ between patients and controls. The alphoid-HindIII polymorphism was not related to blood pressures in our population (HindIII+: diastolic, 80 +/- 2; systolic, 129 +/- 5. HindIII-: diastolic, 80 +/- 2; systolic, 128 +/- 3). Seventy-six patients (37%) were hypertensives and had a significantly higher frequency of the HindIII+ allele compared to the normotensive patients (46 and 26%, respectively; P = 0.028). According to our data, the alphoid-HindIII polymorphism in chromosome Y was not associated with differences in blood pressure in men from Asturias (Northern Spain). However, the HindIII+ allele increased the risk of suffering an early episode of MI among hypertensives.
García
Eliecer Coto
EC
Genética Molecular-Instituto de Investigación Nefrológica (IRSIN-FRIAT), Hospital Central Asturias (Maternidad), 33006 Oviedo, Spain. ecoto@hcas.sespa.es
González
Pelayo
P
Castro
Mónica G
MG
Alvarez
Ruth
R
Reguero
Julián R
JR
Batalla
Alberto
A
Cortina
Arturo
A
Alvarez
Victoria
V
D000328:Adult; D001665:Binding Sites / Q000235:genetics; D001794:Blood Pressure / Q000235:genetics; D041322:Chromosomes, Human, Y / Q000235:genetics*; D004276:DNA, Satellite / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics; D015247:Deoxyribonuclease HindIII / Q000378:metabolism; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000235:genetics*; D009687:Nuclear Proteins; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors
D004276:DNA, Satellite; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C497745:SRY protein, human; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors; D015247:Deoxyribonuclease HindIII