title: The relationship between tumor thickness and clinical and histopathologic parameters in cancer of the larynx.
abstract: OBJECTIVE
  We sought to determine the relationship of tumor thickness to clinical and histopathologic parameters in laryngeal cancer. Study design and setting We conducted a retrospective review of laryngectomy specimens of 111 surgically treated T1-3 laryngeal cancer patients for tumor thickness and various histopathologic parameters.
  
  
  RESULTS
  Tumor thickness was significantly related to T, N, and clinical stage; pathologic cervical lymph node metastasis; cartilage invasion; microscopic appearance; mode of invasion to surrounding tissues; perineural invasion; and lymphocytic infiltration (P < 0.05). Tumor thickness had significant correlation with T, N, and clinical stage; cervical lymph node metastasis; cartilage invasion; mode of invasion to surrounding tissues; perineural invasion; and lymphocytic infiltration (P < 0.05). Multifactorial statistical analysis showed that cartilage invasion and lymphocytic infiltration significantly determined tumor thickness independently (P < 0.05).
  
  
  CONCLUSIONS
  Tumor thickness is well correlated to most of the reliable clinical and histopathologic parameters, and it is an objective and easy-to-obtain measure.
  
  
  CONCLUSIONS
  Tumor thickness can be used as a reliable histopathological factor and should be measured in every laryngectomy specimen.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey. taneryilmaz@yahoo.com
authors.forename: Taner
authors.initials: T
authors.lastname: Yilmaz
authors.forename: Gökhan
authors.initials: G
authors.lastname: Gedikoğlu
authors.forename: Bülent
authors.initials: B
authors.lastname: Gürsel
mesh_terms: D000328:Adult; D000368:Aged; D002356:Cartilage / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000098:blood supply / Q000473:pathology* / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012189:Retrospective Studies; D019043:Vascular Neoplasms / Q000473:pathology