title: Long-term effects of octreotide therapy on in-stent restenosis.
abstract: The purpose of this study was to assess the long-term effects of octreotide therapy on in-stent restenosis at 6-month follow-up coronary angiography and the clinical events after stenting. A randomized, double-blind, placebo-controlled trial was conducted to assess the effects of octreotide on restenosis after stenting. The patients ( n = 148) received either subcutaneous octreotide or placebo 1 h before the stenting procedure and then every 8 h for 3 weeks. Percent diameter stenosis was interpreted before and after stenting, and on a 6-month follow-up coronary angiogram by quantitative coronary angiography. The mean percent diameter stenosis of the octreotide group was significantly lower than that of the placebo group on the 6-month follow-up coronary angiograms (18.8% +/- 14.2% vs 35.0% +/- 19.2%, respectively; P = 0.001). The restenosis rate of the octreotide group was statistically lower than that of the placebo group (11.8% vs 26.4%, respectively; P << 0.05). With regard to major cardiovascular events, there was no significant difference between the octreotide and placebo groups. The administration of octreotide for treatment of in-stent restenosis results in a relatively low long-term angiographic restenosis rate and no significant acute effects on cardiovascular clinical events.
authors.affiliation: Department of Cardiology, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: S Hurkan
authors.initials: SH
authors.lastname: Kursaklioglu
authors.forename: Atila
authors.initials: A
authors.lastname: Iyisoy
authors.forename: Basri
authors.initials: B
authors.lastname: Amasyali
authors.forename: Cem
authors.initials: C
authors.lastname: Barcin
authors.forename: Sedat
authors.initials: S
authors.lastname: Kose
authors.forename: Turgay
authors.initials: T
authors.lastname: Celik
authors.forename: Ayhan
authors.initials: A
authors.lastname: Kilic
authors.forename: Cengiz
authors.initials: C
authors.lastname: Ozturk
authors.forename: Ertan
authors.initials: E
authors.lastname: Demirtas
mesh_terms: D000328:Adult; D000368:Aged; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000628:therapy; D023903:Coronary Restenosis / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D015607:Stents; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015282:Octreotide