The relationship between tumor thickness and clinical and histopathologic parameters in cancer of the larynx.
OBJECTIVE
We sought to determine the relationship of tumor thickness to clinical and histopathologic parameters in laryngeal cancer. Study design and setting We conducted a retrospective review of laryngectomy specimens of 111 surgically treated T1-3 laryngeal cancer patients for tumor thickness and various histopathologic parameters.


RESULTS
Tumor thickness was significantly related to T, N, and clinical stage; pathologic cervical lymph node metastasis; cartilage invasion; microscopic appearance; mode of invasion to surrounding tissues; perineural invasion; and lymphocytic infiltration (P < 0.05). Tumor thickness had significant correlation with T, N, and clinical stage; cervical lymph node metastasis; cartilage invasion; mode of invasion to surrounding tissues; perineural invasion; and lymphocytic infiltration (P < 0.05). Multifactorial statistical analysis showed that cartilage invasion and lymphocytic infiltration significantly determined tumor thickness independently (P < 0.05).


CONCLUSIONS
Tumor thickness is well correlated to most of the reliable clinical and histopathologic parameters, and it is an objective and easy-to-obtain measure.


CONCLUSIONS
Tumor thickness can be used as a reliable histopathological factor and should be measured in every laryngectomy specimen.
Yilmaz
Taner
T
Department of Otolaryngology, Head and Neck Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey. taneryilmaz@yahoo.com
Gedikoğlu
Gökhan
G
Gürsel
Bülent
B
D000328:Adult; D000368:Aged; D002356:Cartilage / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000098:blood supply / Q000473:pathology* / Q000601:surgery*; D007825:Laryngectomy / Q000379:methods; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012189:Retrospective Studies; D019043:Vascular Neoplasms / Q000473:pathology