title: Relationship between development of diabetes and family history by gender in Japanese-Americans.
abstract: Japanese-Americans are more highly exposed to environmental factors related to diabetes, specifically a westernized lifestyle, compared with Japanese living in Japan. We investigated the relationship between family history and development of type 2 diabetes by gender in the westernized environment. Nine-hundred-and-sixty non-diabetic Japanese-American subjects who underwent the 75 g oral glucose tolerance test were followed for 6.8+/-0.1 years (mean+/-standard error). In a log-rank test, women with a family history showed a significantly higher incidence of type 2 diabetes compared with those without a family history (P=0.018), whereas men showed no significant difference (P=0.25). In a Cox proportional hazards model, the hazard ratio of developing diabetes in men and women with a positive family history were 1.56 (95% confidence interval [CI] 0.81-2.97) and 1.86 (95% CI 1.08-3.19), respectively. This association, which indicated a hazard ratio of 1.79 (95% CI 1.04-3.10), persisted even after adjustment for age, systolic, diastolic blood pressure, triglycerides, HDL-cholesterol, category of normal glucose tolerance (NGT) and impaired glucose tolerance (IGT), body mass index and homeostasis model assessment (HOMA-R) in women. Our findings suggest that even if lifestyle is westernized, a family history of diabetes is an important predictor of type 2 diabetes development especially among women in Japanese-American population.
authors.affiliation: Department of Molecular and Internal Medicine, Division of Clinical Medical Science, Programs for Applied Biomedicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. nshuhei@rerf.or.jp
authors.forename: Shuhei
authors.initials: S
authors.lastname: Nakanishi
authors.forename: Kiminori
authors.initials: K
authors.lastname: Yamane
authors.forename: Nozomu
authors.initials: N
authors.lastname: Kamei
authors.forename: Masamichi
authors.initials: M
authors.lastname: Okubo
authors.forename: Nobuoki
authors.initials: N
authors.lastname: Kohno
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007564:Japan / Q000208:ethnology; D008019:Life Style; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors; D014481:United States / Q000453:epidemiology