title: [Chlamydia pneumoniae--etiology of ophthalmia neonatorum].
abstract: The authors observed mucous discharge in palpebral aperture, accompanied by a different degree of effusion of eyelids and chemosis of conjunctivae, particularly the tarsal ones, in 12 physiological newborns. Chlamydia pneumoniae proved to be the etiological agent in the newborn ophthalmia. The eye infection was not detected in the same period of time and in the same maternity hospital in the period of observation from September 1999 to March 2001. The detection of Chlamydia pneumoniae was performed in conjunctiva smears. The impression films on slides were examined by the method of indirect immunofluorescence with the use of specific monoclonal antibodies (medac, Germany). In the early stages the secretion included a sanguineous component, which was then changing into a mucoid or mucopurulent form. The character of conjunctival symptoms was changing in the course of inflammation. Effusion of the lower transitory fold (plica) was gradually accompanied by a picture of pseudofollicular changes on the tarsal conjunctiva. Clarithromycin in the form of syrup at daily doses of 15 mg/kg/day for the period of two weeks offered an efficient therapy of the affection. Control smears after 14 days were always negative and, at the same time, the pathological finding on the conjunctivae disappeared. The nasolacrimal obstruction was the only complication of this chlamydia infection, taking place in seven sucklings, i.e. in 58%. The passage through lacrimal drainage system reappeared in all the affected infants until they reached one year of age. The remaining question to be answered is the way the newborns encountered the infection. A nosocomial infection may be the case, but Chlamydia pneumoniae could also be present in the urogenital tract of mothers and transferred to the newborn via the birth canal similarly as is the case of Chlamydia trachomatis infection. The mode of infection deserves further investigation.
authors.affiliation: Ocní klinika FN Královské Vinohrady, Praha. krasny@fnkv.cz
authors.forename: J
authors.initials: J
authors.lastname: Krásný
authors.forename: J
authors.initials: J
authors.lastname: Borovanská
authors.forename: D
authors.initials: D
authors.lastname: Hrubá
mesh_terms: D002690:Chlamydia Infections / Q000175:diagnosis; D016993:Chlamydophila pneumoniae; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009878:Ophthalmia Neonatorum / Q000175:diagnosis / Q000382:microbiology*
vernacular_title: Chlamydia pneumoniae--etiologie ophthalmia neonatorum.