title: Susceptibility of mixed infection of Ureaplasma Urealyticum and Mycoplasma Hominis to seven antimicrobial agents and comparison with that of Ureaplasma Urealyticum infection.
abstract: In order to investigate the susceptibility of mixed infection of Ureaplasma Urealyticum (UU) and Mycoplasma Hominis (MH) to 7 kinds of antimicrobial agents and comparison with that of UU infection in NGU patients, the in vitro susceptibility was determined by using microdilution method. The positive results were analyzed. The results showed that the sequence of susceptibility to 7 kinds of antimicrobial agents for both UU infection group and UU-MH mixed infection group was almost the same from the highest susceptibility to the lowest accordingly: Josamycin, Doxycycline, Minocycline, Sparfloxacin, Roxithromycin, Ofloxacin and Azithromycin. The total drug resistance rate for UU-MH mixed infection group (97.67%) was significantly higher than that for UU infection group (44.67%, P < 0.01). The highest drug resistance rate in UU group and UU-MH mixed infection group was 31.33% (Ofloxacin) and 90.48% (Azithromycin) respectively. UU-MH mixed infection showed an increased drug resistance and changes of drug resistance spectrum.
authors.affiliation: Department of Dermatology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
authors.forename: Changzheng
authors.initials: C
authors.lastname: Huang
authors.forename: Zhixiang
authors.initials: Z
authors.lastname: Liu
authors.forename: Nengxing
authors.initials: N
authors.lastname: Lin
authors.forename: Yating
authors.initials: Y
authors.lastname: Tu
authors.forename: Jiawen
authors.initials: J
authors.lastname: Li
authors.forename: Demei
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D004318:Doxycycline / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D015570:Josamycin / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000494:pharmacology; D009175:Mycoplasma Infections / Q000150:complications / Q000382:microbiology; D019535:Mycoplasma hominis / Q000187:drug effects* / Q000302:isolation & purification; D015242:Ofloxacin / Q000494:pharmacology; D015163:Superinfection; D016869:Ureaplasma Infections / Q000150:complications / Q000382:microbiology; D016990:Ureaplasma urealyticum / Q000187:drug effects* / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin; D015242:Ofloxacin; D008911:Minocycline; D015570:Josamycin; D004318:Doxycycline