title: Safety and efficacy of tacrolimus rescue therapy in 55 kidney transplant patients treated with cyclosporine.
abstract: To evaluate the efficacy and safety of conversion from cyclosporine to tacrolimus, we analyzed 55 kidney transplant patients who were converted due to cosmetic reasons in 42 patients, acute rejection in 2 patients, and other causes in 11 patients. At the doses and levels used, the development of diabetes mellitus was minimized. Disappearance of cosmetic side-effects and improvement of cardiovascular risk factors, together with conservation of renal function, encourage us to use tacrolimus as an efficacious and safe immunosuppressive therapy.
authors.affiliation: Nephrology Service, Hospital de Cruces, Baracaldo, Bizkaia, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Urbizu
authors.forename: S
authors.initials: S
authors.lastname: Zárraga
authors.forename: P
authors.initials: P
authors.lastname: Gómez-Ullate
authors.forename: J J
authors.initials: JJ
authors.lastname: Amenábar
authors.forename: F I
authors.initials: FI
authors.lastname: Gaínza
authors.forename: I
authors.initials: I
authors.lastname: Lampreabe
authors.forename: J
authors.initials: J
authors.lastname: Virto
authors.forename: J
authors.initials: J
authors.lastname: Orbe
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D016572:Cyclosporine / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D012189:Retrospective Studies; D012449:Safety; D016559:Tacrolimus / Q000627:therapeutic use*; D013997:Time Factors; D014527:Uric Acid / Q000097:blood
chemical_list: D001786:Blood Glucose; D007166:Immunosuppressive Agents; D014527:Uric Acid; D016572:Cyclosporine; D002784:Cholesterol; D016559:Tacrolimus