Derivatives of 2-mercaptobenzenesulphonamide. VIII. Synthesis and some pharmacological properties of 1,3-dialkyl-2-(4-chloro-2-carboxyalkylthio-5-methylbenzenesulphonyl) guanidines.
Synthesis of 1,3-dialkyl-2-(4-chloro-2-carboxyalkylthio-5-methylbenzenesulphonyl)guanidines (IX-XVII) and their easily soluble in water sodium (Xa-XIVa, XVIIa) or 2,6-dimethylpiperidine salts (XIb, XVIIb) have been described. The results of preliminary pharmacological examinations such as acute toxicity and influence on circulatory system have been presented.
Brzozowski
Z
Z
Department of Drug Technology, School of Medicine, 107 K. Marksa Str., 80-416 Gdańsk, Poland.
Sławiński
J
J
Filczewski
M
M
Szymańska-Kosmala
M
M
Miłobedzka
J
J
Oledzka
K
K
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D006146:Guanidines / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D006339:Heart Rate / Q000187:drug effects; D007202:Indicators and Reagents; D007928:Lethal Dose 50; D051379:Mice; D051381:Rats; D013329:Structure-Activity Relationship
D000889:Anti-Arrhythmia Agents; D006146:Guanidines; D007202:Indicators and Reagents