A 22-year French experience with solid tumors in children with Down syndrome.
Malignant solid tumors have rarely been reported in children with Down syndrome (DS) and are not well known. The authors collected from 1980 to 2001 all cases of solid tumors observed in DS patients aged from birth to 19 years within the network of the Société Française d'Oncologie Pédiatrique (SFOP). Only 21 cases were observed, with a peculiar distribution: a lack of intracranial tumors and embryonal neoplasms combined with an overrepresentation of lymphomas and germ cell tumors. The treatment of solid tumors in DS is difficult, due to physical and psychological impairments, different pharmacogenetic profile, and associated malformations.
Satgé
Daniel
D
Laboratoire d'Anatomie Pathologique, Centre Hospitalier, Tulle, France. daniel.satge@ch-tulle.fr
Sasco
Annie J
AJ
Chompret
Agnès
A
Orbach
Daniel
D
Méchinaud
Françoise
F
Lacour
Brigitte
B
Roullet
Bernard
B
Martelli
Hélène
H
Bergeron
Christophe
C
Bertrand
Yves
Y
Lacombe
Didier
D
Perel
Yves
Y
Monteil
Pascal
P
Nelken
Brigitte
B
Bertozzi
Anne-Isabelle
AI
Munzer
Martine
M
Kanold
Justine
J
Bernard
Fréderic
F
Vekemans
Michel J
MJ
Sommelet
Danièle
D
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004314:Down Syndrome / Q000150:complications* / Q000453:epidemiology; D005260:Female; D005602:France; D019337:Hematologic Neoplasms / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D009373:Neoplasms, Germ Cell and Embryonal / Q000209:etiology; D012189:Retrospective Studies