Antifungal activity of fractions and two pure compounds of flowers from Wedelia paludosa (Acmela brasiliensis) (Asteraceae).
Wedelia paludosa (Acmela brasiliensis) (Asteraceae), a traditionally used native Brazilian medicinal plant, showed antifungal activity against dermatophytes in dilution tests. The hexane, dichloromethane and butanol fractions displayed activity against Epidermophyton floccosum, Trichophyton rubrum and Trichophyton mentagrophytes, with minimal inhibitory concentrations between 250 and 1000 microg/mL. Two pure compounds, identified as kaurenoic acid (1) and luteolin (2), also showed activity against these dermatophytes.
Sartori
M R K
MR
Programa de Mestrado em Ciências Farmacêuticas/CCS, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Brazil.
Pretto
J B
JB
Cruz
A B
AB
Bresciani
L F V
LF
Yunes
R A
RA
Sortino
M
M
Zacchino
S A
SA
Cechinel
V Filho
VF
D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003470:Culture Media; D004224:Diterpenes / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology; D035264:Flowers / Q000737:chemistry; D005658:Fungi / Q000187:drug effects*; D047311:Luteolin; D000432:Methanol; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D031209:Wedelia / Q000737:chemistry*
D000935:Antifungal Agents; D003470:Culture Media; D004224:Diterpenes; D005419:Flavonoids; D010936:Plant Extracts; C051436:kaurenoic acid; D047311:Luteolin; D000432:Methanol