Risk of death in pregnancy achieved through oocyte donation in patients with Turner syndrome: a national survey.
To determine the risk of death in pregnant women with Turner syndrome who were treated with oocyte donation, and to ascertain the prevalence of preconception cardiac screening in these patients.


METHODS
Survey and literature review.


METHODS
Academic infertility center.


METHODS
All 258 donor-egg programs in the 1997 Assisted Reproductive Technology Success Rates publication from the Society for Artificial Reproductive Technology were surveyed by fax or telephone.


METHODS
Death in pregnancy conceived through oocyte donation and proportion of patients prescreened with echocardiography.


RESULTS
One hundred thirty-four (52%) programs reported 146 Turner patients treated, resulting in 101 pregnancies. One patient died from aortic rupture while awaiting treatment; 72 (49.3%) patients were pre- screened with echocardiography. No deaths in pregnancy were reported. A literature review identified four case reports of Turner patients who died during pregnancy in the United States during the same time period.


CONCLUSIONS
The maternal risk of death from rupture or dissection of the aorta in pregnancy may be 2% or higher. Patients with Turner syndrome have not been adequately screened with echocardiography before treatment. Specialists who treat patients with Turner syndrome need to be aware of their cardiac risk and its potential exacerbation from the increased cardiac demands of pregnancy.
Karnis
Megan Freebury
MF
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology and Reproductive Biology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston IVF, Boston, Massachusetts, USA.
Zimon
Alison Elizabeth
AE
Lalwani
Sasmira Indru
SI
Timmreck
Lorna Smink
LS
Klipstein
Sigal
S
Reindollar
Richard Henry
RH
D000784:Aortic Dissection / Q000209:etiology / Q000401:mortality*; D017542:Aneurysm, Ruptured / Q000209:etiology / Q000401:mortality*; D001014:Aortic Aneurysm / Q000209:etiology / Q000401:mortality*; D005260:Female; D006801:Humans; D018587:Oocyte Donation; D011159:Population Surveillance; D011247:Pregnancy; D011248:Pregnancy Complications / Q000401:mortality*; D012307:Risk Factors; D014424:Turner Syndrome / Q000150:complications*