title: Visceral adiposity and the prevalence of hypertension in Japanese Americans.
abstract: BACKGROUND
  Visceral adiposity is generally considered to play a key role in the metabolic syndrome, including hypertension. The purpose of this study was to evaluate cross-sectionally whether visceral adiposity is associated with prevalence of hypertension independent of other adipose depots and fasting plasma insulin.
  
  
  RESULTS
  Study subjects included 563 Japanese Americans with normal or impaired glucose tolerance or diabetes but not taking oral hypoglycemic medication or insulin at entry. Variables included plasma glucose and insulin measured after an overnight fast and during an oral glucose tolerance test, and abdominal, thoracic, and thigh fat areas by CT. Total fat area (TFA) was calculated as the sum of these fat areas. Hypertension was defined as having a systolic blood pressure > or =140 mm Hg, having a diastolic blood pressure > or =90 mm Hg, or taking antihypertensive medications. Intra-abdominal fat area (IAFA) was associated with a higher prevalence of hypertension. Adjusted odds ratio of hypertension by IAFA was 1.68 for a 1-SD increase (95% CI, 1.20 to 2.37) after adjusting for age, sex, fasting plasma insulin, a nonlinear transformation of 2-hour plasma glucose, and TFA. IAFA remained a significant predictor of prevalence of hypertension even after adjustment for total subcutaneous fat area, abdominal subcutaneous fat area, body mass index, or waist circumference, but no measure of regional or total adiposity was associated with the odds of prevalence of hypertension in models that contained IAFA.
  
  
  CONCLUSIONS
  Greater visceral adiposity increases the odds of hypertension in Japanese Americans independent of other adipose depots and fasting plasma insulin.
authors.affiliation: Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Wash 98108, USA.
authors.forename: Tomoshige
authors.initials: T
authors.lastname: Hayashi
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Boyko
authors.forename: Donna L
authors.initials: DL
authors.lastname: Leonetti
authors.forename: Marguerite J
authors.initials: MJ
authors.lastname: McNeely
authors.forename: Laura
authors.initials: L
authors.lastname: Newell-Morris
authors.forename: Steven E
authors.initials: SE
authors.lastname: Kahn
authors.forename: Wilfred Y
authors.initials: WY
authors.lastname: Fujimoto
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000208:ethnology*; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000473:pathology; D015995:Prevalence; D012307:Risk Factors; D014481:United States / Q000453:epidemiology; D014781:Viscera / Q000473:pathology