Synthesis and structure of some alpha,beta-unsaturated amidoesters--Part I.
Fourteen new analogues of 1,4-bis(3-alkyloxycarbonylacryloyl)-2-methylpiperazine were obtained for antineoplastic screening. Also the crystal structure of one compound has been studied by X-ray diffraction method to determine electronic structure and conformation of 3-alkyloxycarbonylacryloyl moiety.
Najman
L
L
Department of Pharmaceutical Chemistry and Drug Analysis, School of Medicine, Lódź.
Główka
M L
ML
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
C477558:1,4-bis(3-ethoxycarbonylacryloyl)-2-methylpiperazine; D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D010879:Piperazines