title: Effects of topical L-selenomethionine with topical and oral vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice.
abstract: BACKGROUND
  The antioxidants selenium and vitamin E can be effective in reducing acute and chronic ultraviolet (UV)-induced skin damage.
  
  
  OBJECTIVE
  This study investigated whether topical L-selenomethionine with topical RRR-alpha-tocopherol (Eol) or oral RRR-alpha-tocopheryl acetate (Eac) can reduce the incidence of UV-induced skin damage more than treatment with each alone.
  
  
  METHODS
  Skh:2 hairless pigmented mice were treated with lotion vehicle, L-selenomethionine lotion, Eol lotion, oral Eac, L-selenomethionine plus Eol lotion, or L-selenomethionine lotion plus oral Eac and exposed to UVB. Skin pigmentation was scored, and the number of skin tumors per animal was counted weekly.
  
  
  RESULTS
  Mice treated with selenium and vitamin E had significantly less acute and chronic UV-induced skin damage.
  
  
  CONCLUSIONS
  Topical L-selenomethionine alone and combined with vitamin E gave the best protection against UV-induced blistering and pigmentation. In protecting against skin cancer, topical Eol and topical L-selenomethionine plus oral Eac were best. Significant synergy of L-selenomethionine with vitamin E was not observed.
authors.affiliation: Department of Biostatistics, University of Connecticut Health Center, Farmington, USA.
authors.forename: Karen E
authors.initials: KE
authors.lastname: Burke
authors.forename: Jonathan
authors.initials: J
authors.lastname: Clive
authors.forename: Gerald F
authors.initials: GF
authors.lastname: Combs
authors.forename: Robert M
authors.initials: RM
authors.lastname: Nakamura
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced / Q000188:drug therapy* / Q000517:prevention & control; D011897:Random Allocation; D012016:Reference Values; D012645:Selenomethionine / Q000494:pharmacology*; D012680:Sensitivity and Specificity; D012867:Skin / Q000187:drug effects / Q000473:pathology*; D012878:Skin Neoplasms / Q000188:drug therapy*; D012880:Skin Pigmentation / Q000187:drug effects*; D014018:Tissue Distribution; D016896:Treatment Outcome; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D014810:Vitamin E; D012645:Selenomethionine