Treatment of asymptomatic bacterial vaginosis to prevent pre-term delivery: a randomised trial.
OBJECTIVE
To evaluate the efficacy of clindamycin vaginal cream 2% once daily for 7 days in prolonging pregnancy.


METHODS
Randomised clinical trial of 112 women between 14 and 25 weeks of gestation with diagnosis of asymptomatic bacterial vaginosis were enrolled in a multicenter randomised trial and assigned to active or no treatment. A total of 55 women were assigned to clindamycin and 57 to no treatment.


METHODS
frequency of pre-term delivery.


RESULTS
The rates of pre-term delivery was 12.2% in the clindamycin group and 15.7% in the no treatment group (P=0.78). Birth weight was <2500 g in three and seven babies, respectively, in the two groups (P=0.32). Mean gestational ages at birth were 38.9 and 39.2 (P=0.52), respectively, in the clindamycin and no treatment groups.


CONCLUSIONS
The results of this study suggest that treating asymptomatic bacterial vaginosis does neither markedly prolong pregnancy nor increase birthweight.
Guaschino
Secondo
S
Clinica Ostetrico Ginecologica, Università di Trieste, Trieste, Italy.
Ricci
Elena
E
Franchi
Massimo
M
Frate
Giovanni Del
GD
Tibaldi
Cecilia
C
Santo
Daniele De
DD
Ghezzi
Fabio
F
Benedetto
Chiara
C
Seta
Francesco De
FD
Parazzini
Fabio
F
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001724:Birth Weight; D002981:Clindamycin / Q000627:therapeutic use*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D007752:Obstetric Labor, Premature / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control*; D011247:Pregnancy; D016896:Treatment Outcome; D016585:Vaginosis, Bacterial / Q000150:complications / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D002981:Clindamycin