Outcome of Staphylococcus aureus bacteremia in patients with eradicable foci versus noneradicable foci.
To determine the outcome of Staphylococcus aureus bacteremia (SAB) on mortality, including the impact of methicillin resistance and an initial delay (< or =48 h) of appropriate antibiotics, a retrospective cohort study including 238 patients with SAB was performed. By logistic regression, noneradicable or noneradicated foci, underlying cirrhosis, and cancer were found to be independent predictors of mortality. In patients with eradicable foci, there were no significant differences in the associated mortality rate between methicillin-resistant SAB (11%) and methicillin-susceptible SAB (13%), and between inappropriate (13%) and appropriate (10%) empirical therapy, respectively (P=.79 and P=.78, respectively). By logistic regression, it was found that, in the subgroup of patients with noneradicable foci, underlying cirrhosis (odds ratio [OR], 3.1) and methicillin-resistant SAB (OR, 2.4) were independently associated with mortality.
Kim
Sung-Han
SH
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Park
Wan-Bum
WB
Lee
Ki-Deok
KD
Kang
Cheol-In
CI
Kim
Hong-Bin
HB
Oh
Myoung-don
MD
Kim
Eui-Chong
EC
Choe
Kang-Won
KW
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D015331:Cohort Studies; D003428:Cross Infection; D005260:Female; D006801:Humans; D008297:Male; D008712:Methicillin / Q000494:pharmacology; D016106:Methicillin Resistance / Q000502:physiology*; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D013211:Staphylococcus aureus / Q000187:drug effects; D015996:Survival Rate
D000900:Anti-Bacterial Agents; D008712:Methicillin