Simple evaluation of the wound healing activity of a crude extract of Portulaca oleracea L. (growing in Jordan) in Mus musculus JVI-1.
The preliminary wound healing activity of Portulaca oleracea was studied using Mus musculus JVI-1. For this purpose fresh homogenized crude aerial parts of Portulaca oleracea were applied topically on the excision wound surface as single and two doses in different amounts. Wound contraction and tensile strength measurements were used to evaluate the effect of Portulaca oleracea on wound healing. The results obtained indicated that Portulaca oleracea accelerates the wound healing process by decreasing the surface area of the wound and increasing the tensile strength. The greatest contraction was obtained at a single dose of 50mg and the second greatest by two doses of 25mg. Measurements of tensile strength and healed area were in agreement.
Rashed
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Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan.
Afifi
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Disi
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D000287:Administration, Topical; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007597:Jordan; D008297:Male; D051379:Mice; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D031822:Portulaca / Q000737:chemistry*; D012867:Skin / Q000187:drug effects / Q000293:injuries; D012879:Skin Physiological Phenomena / Q000187:drug effects; D013718:Tensile Strength / Q000187:drug effects / Q000502:physiology; D014945:Wound Healing / Q000187:drug effects*; D014950:Wounds, Penetrating / Q000188:drug therapy / Q000503:physiopathology
D010936:Plant Extracts