Derivation and differentiation of glomerular endothelial cells.
Data on the embryonic derivation of metanephric endothelial cells are reviewed, paying particular attention to results obtained from anterior chamber and intrarenal grafts of embryonic kidneys. Most of the evidence supports an intrinsic origin of the endothelium, which probably differentiates from metanephric mesenchyme. The roles of several growth factor receptor/ligand systems are also discussed, with an emphasis on the VEGF receptors, Flk1 and neuropilin-1.
Abrahamson
Dale R
DR
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Rainbow Boulevard, Kansas City, Kansas 66160-7400, USA. dabrahamson@kurnc.edu
Robert
Barry
B
D002454:Cell Differentiation / Q000502:physiology*; D042783:Endothelial Cells / Q000166:cytology*; D006801:Humans; D007678:Kidney Glomerulus / Q000196:embryology* / Q000502:physiology