Vascular in situ activation radiation therapy insitustent dosimetry.
OBJECTIVE
To investigate the radiation dosimetry of a stable stent following activation by a linac photon beam.


METHODS
A computer simulation is used in conjunction with neutron measurements to study the dosimetry of a stent activated by a linac photon beam. Two models are investigated. A gamma emitter, Model G108, with no half-life and 1.43 MeV average energy, and a beta emitter, Model D108, with 2.33 h half-life and 0.45 MeV average energy.


RESULTS
Model D108 delivers a dose exceeding 1 Gy to the artery wall when exposed to an 18-MV photon beam. Model G108 requires a 25-MV photon beam to deliver a similar dose under the same conditions of irradiation.


CONCLUSIONS
The very short to no half-life of InSituStent emissions makes the fractionation of the dose delivery possible. In addition, an InSituStent coated with an immunosuppressant drug may give patients the potential benefit of a combined radiation and drug treatments.
Adnani
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NTI Medical Inc., Suite 1150, Manulife Place, 10180-101 Street, Edmonton, Alberta, Canada T5J 3S4. adnani@ntimedical.com
D001918:Brachytherapy / Q000295:instrumentation* / Q000379:methods*; D003198:Computer Simulation; D023903:Coronary Restenosis / Q000532:radiotherapy* / Q000601:surgery*; D003331:Coronary Vessels / Q000528:radiation effects* / Q000601:surgery*; D019583:Dose Fractionation, Radiation; D004730:Endothelium, Vascular / Q000528:radiation effects / Q000601:surgery; D006801:Humans; D008955:Models, Cardiovascular; D009501:Neutron Activation Analysis; D010315:Particle Accelerators; D011874:Radiometry; D015607:Stents