Syndecan-4: dispensable or indispensable?
Studies examining the role of the cell-surface heparan sulfate proteoglycan syndecan-4 have yielded a plethora of information regarding its role in both cell-matrix and growth-factor mediated signaling events. Many of the initial conclusions drawn from such research placed syndecan-4 in a keystone position within various signaling pathways though the generation of syndecan-4 null mice have surprised many in the field by indicating otherwise. These contradictory results place researchers in the frustrating and yet exhilarating position of still asking the question, "What role does syndecan-4 play in life?"
Wilcox-Adelman
Sarah A
SA
Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. sarah.wilcox-adelman@cbrc2.mgh.harvard.edu
Denhez
Fabienne
F
Iwabuchi
Tokuro
T
Saoncella
Stefania
S
Calautti
Enzo
E
Goetinck
Paul F
PF
D000818:Animals; D002465:Cell Movement; D022001:Focal Adhesions; D015870:Gene Expression; D006133:Growth Substances / Q000502:physiology; D019812:Heparan Sulfate Proteoglycans / Q000502:physiology; D008562:Membrane Glycoproteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D011493:Protein Kinase C / Q000502:physiology; D011509:Proteoglycans / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D053671:Syndecan-4
D006133:Growth Substances; D019812:Heparan Sulfate Proteoglycans; D008562:Membrane Glycoproteins; D011509:Proteoglycans; C508306:Sdc4 protein, mouse; D053671:Syndecan-4; D011493:Protein Kinase C