title: The contribution of signaling pathways to olfactory organization and development.
abstract: The exquisite specificity in the organization of the mammalian olfactory system underlies its remarkable sensitivity and precision in odorant detection. The contribution of olfactory receptor proteins to the initial patterning of connections between the sensory epithelium and the bulb is widely appreciated. The application of genetic model systems has revealed additional roles for odorant-evoked activity in the development, organization and dynamic turnover of cells in this regenerating sensory organ.
authors.affiliation: Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. rreed@jhmi.edu
authors.forename: Randall R
authors.initials: RR
authors.lastname: Reed
mesh_terms: D000818:Animals; D006801:Humans; D009434:Neural Pathways / Q000502:physiology; D009830:Olfactory Bulb / Q000166:cytology / Q000254:growth & development*; D018035:Receptors, Odorant / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D012903:Smell / Q000502:physiology*
chemical_list: D018035:Receptors, Odorant