title: No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.
abstract: OBJECTIVE
  There has been a recent resurgence in interest in the role of autoimmunity in childhood neuropsychiatric disorders. Significant association between HLA-DRB1 and attention deficit hyperactivity disorder (ADHD) in a case-control study of 31 subjects has been reported but there have been no other published studies following up these results. We attempted to replicate these findings.
  
  
  METHODS
  In a well-characterized sample of 173 children with ADHD, using a fully automated sequence-specific oligonucleotide method for HLA genotyping, association between ADHD and HLA-DRB1 was tested for using the Transmission Disequilibrium Test and case-control analysis.
  
  
  RESULTS
  Transmission Disequilibrium Test analysis yielded a chi-square of 10.694 with a simulated global P value of 0.1641 for the full sample, and a chi-square value of 11.307 with a simulated global P value of 0.1323 for the complete trios only.
  
  
  CONCLUSIONS
  There was no evidence of association of HLA-DRB1 and ADHD.
authors.affiliation: Centre for Integrated Genomic Medical Research, Stopford Building, Manchester University, Manchester, UK.
authors.forename: Antony
authors.initials: A
authors.lastname: Payton
authors.forename: Darko
authors.initials: D
authors.lastname: Turic
authors.forename: Kate
authors.initials: K
authors.lastname: Langley
authors.forename: Sophie
authors.initials: S
authors.lastname: Mills
authors.forename: Deborah C
authors.initials: DC
authors.lastname: Lawson
authors.forename: Marianne
authors.initials: M
authors.lastname: Van den Bree
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owen
authors.forename: Michael C
authors.initials: MC
authors.lastname: O'Donovan
authors.forename: William
authors.initials: W
authors.lastname: Ollier
authors.forename: Jane
authors.initials: J
authors.lastname: Worthington
authors.forename: Anita
authors.initials: A
authors.lastname: Thapar
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics* / Q000276:immunology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D015810:Linkage Disequilibrium
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains