title: MR imaging of the fetal brain and spine: a maturing technology.
abstract: BACKGROUND
  We describe the background and refinements to a 3-year research study designed to evaluate the role of magnetic resonance (MR) imaging in detecting and defining abnormalities of the fetal central nervous system in utero.
  
  
  METHODS
  We describe our experience of using ultra-fast MR imaging methods (specifically single-shot fast spin echo) in 250 fetuses at various gestational ages. All fetuses had known or suspected brain or spine abnormalities based on antenatal ultrasound imaging. We describe the ethical issues raised by this type of work and the differences in diagnostic accuracy between ultrasound and MR imaging.
  
  
  RESULTS
  We show that MR imaging can be performed in a clinical environment with a high degree of success: only 2 women out of 250 could not be examined (1 was claustrophobic and the other was too large for our scanner). In the 100 cases of singleton pregnancies, where detailed follow-up is available, there is a > 40% improvement in diagnostic accuracy when MR imaging is included in the fetal assessment compared to ultrasound alone.
  
  
  CONCLUSIONS
  We conclude that in utero MR imaging is a powerful tool in the assessment of fetal brain and spine abnormalities, and suggest that further work be undertaken to provide a widely available clinical service.
authors.affiliation: Academic Unit of Radiology, University of Sheffield, United Kingdom. P.Griffiths@Sheffield.ac.uk
authors.forename: P D
authors.initials: PD
authors.lastname: Griffiths
authors.forename: M N
authors.initials: MN
authors.lastname: Paley
authors.forename: E H
authors.initials: EH
authors.lastname: Whitby
mesh_terms: D001921:Brain / Q000473:pathology*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D013677:Medical Laboratory Science; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D012680:Sensitivity and Specificity; D013131:Spine / Q000473:pathology*; D006113:United Kingdom