title: Definition of loss of virological response in trials of antiretroviral drugs.
abstract: Definition of the time of loss of virological response is important when designing a viral load endpoint for trials of antiretroviral drugs. We assessed whether, in patients who achieved a viral load below 50 copies/ml, two consecutive values above 50 copies/ml was really indicative of loss of response. It was common for the viral load to return to below 50 copies/ml with no change in regimen, suggesting that a higher threshold for defining the loss of response is required.
authors.affiliation: Goethe Universitat, Frankfurt, Germany.
authors.forename: Schlomo
authors.initials: S
authors.lastname: Staszewski
authors.forename: Caroline
authors.initials: C
authors.lastname: Sabin
authors.forename: Brenda
authors.initials: B
authors.lastname: Dauer
authors.forename: Alessandro Cozzi
authors.initials: AC
authors.lastname: Lepri
authors.forename: Andrew
authors.initials: A
authors.lastname: Phillips
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents