The cyclization of peptides and depsipeptides.
Constricting the peptide backbone into a more defined conformational form through cyclization is an activity evolved in nature and in synthetic work, the latter straddling only the most recent decades. The resulting conformational constraints increase the probability of an optimum response with bio-receptors. The purpose of this review is to highlight developments that have proved to be reasonably efficient in the macrocyclization of linear precursors into cyclic peptides and depsipeptides.
Davies
John S
JS
Department of Chemistry, University of Wales, Swansea, Singleton Park, Swansea SA2 8PP, UK. j.s.davies@swansea.ac.uk
D000595:Amino Acid Sequence; D000818:Animals; D003500:Cyclization; D053630:Depsides; D062385:Hydroxybenzoates / Q000737:chemistry*; D008956:Models, Chemical; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D011487:Protein Conformation
D053630:Depsides; D062385:Hydroxybenzoates; D009842:Oligopeptides; D010446:Peptide Fragments; D010456:Peptides, Cyclic