[Analysis of HLA matching probability in Guangzhou Cord Blood Bank].
The HLA matching results for 1 060 patients searching donors within 3 000 units of umbilical cord blood in Guangzhou Cord Blood Bank from 1998 to 2002 were analyzed. There were 119 (11.23%) and 992 (93.58%) patients found 6/6 and more than 4/6 of HLA matched loci of unrelated cord blood donors respectively. 61.29% of probability in all patients could find one or more cord blood with 4/6 or more matched loci and total nucleated cell (TNC) dose of >or= 3.7 x 10(7)/kg. The highest mean body weight in these supplied patients was 79 kg. The probability was 89.79% for those patients with TNC dose of >or= 2.0 x 10(7)/kg and >or= 4/6 of HLA loci matched. In these patients, the highest weight was 175 kg. In conclusion, a cord blood bank with 3 000 units or more of cord blood in stock shows a high probability of HLA matching and can meet the requirement of TNC >or= 3.7 x 10(7)/kg dose in child and part of adult patients. The umbilical cord blood is a good alternative stem cell source for all patients including adults.
Li
Yan
Y
Guangzhou Cord Blood Bank, Guangzhou Maternal and Neonatal Hospital, Guangzhou 510180, China. gzcord@163.net
Liao
Can
C
Tang
Xue-Wei
XW
Xie
Xing-Mei
XM
Huang
Yi-Ning
YN
Wu
Jie-Ying
JY
Yang
Xin
X
D001771:Blood Banks; D001835:Body Weight; D005312:Fetal Blood / Q000637:transplantation*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006650:Histocompatibility Testing; D006801:Humans; D011336:Probability