Treatment plan modification using voxel-based weighting factors/dose prescription.
Under various clinical situations, it is desirable to modify the original treatment plan to better suit the clinical goals. In this work, a method to help physicians modify treatment plans based on their clinical preferences is proposed. The method uses a weighted quadratic dose objective function. The commonly used organ-/ROI-based weighting factors are expanded to a set of voxel-based weighting factors in order to obtain greater flexibility in treatment plan modification. Two different but equivalent modification schemes based on Rustem's quadratic programming algorithms--modification of a weighting matrix and modification of prescribed doses--are presented. Case studies demonstrated the effectiveness of the two methods with regard to their capability to fine-tune treatment plans.
Wu
Chuan
C
Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. wuchuan@uams.edu
Olivera
Gustavo H
GH
Jeraj
Robert
R
Keller
Harry
H
Mackie
Thomas R
TR
D000465:Algorithms; D019583:Dose Fractionation, Radiation; D005103:Expert Systems; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D011786:Quality Control; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*