title: Antibody and genetic testing in coeliac disease.
abstract: The description of a range of antibodies associated with coeliac disease has been an important development in the ability to test for this common and treatable condition non-invasively. However, the detection of these antibodies remains unstandardised and the appreciation of the clinical utility of each is evolving. In view of the advances in the diagnosis and understanding of coeliac disease, we discuss: (1) the relative advantages, disadvantages and comparative diagnostic utility of the different antibody tests including the confounding effect of selective IgA deficiency; (2) various technical aspects of these tests; (3) HLA-DQ typing as a supplementary tool to antibody testing; (4) areas of controversy resulting from insufficient or conflicting published data; and (5) potential testing strategies.
authors.affiliation: Division of Immunology, Queensland Health Pathology Services, Brisbane, Australia. richard_wong@health.qld.gov.au
authors.forename: Richard C W
authors.initials: RC
authors.lastname: Wong
authors.forename: Richard H
authors.initials: RH
authors.lastname: Steele
authors.forename: Glenn E M
authors.initials: GE
authors.lastname: Reeves
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Wilson
authors.forename: Anne
authors.initials: A
authors.lastname: Pink
authors.forename: Stephen
authors.initials: S
authors.lastname: Adelstein
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D002446:Celiac Disease / Q000175:diagnosis / Q000235:genetics* / Q000276:immunology*; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D017098:IgA Deficiency; D007159:Immunologic Tests
chemical_list: D001323:Autoantibodies; D006683:HLA-DQ Antigens