title: [Volumetric MRI for evaluation of regional pattern and progressin of neocortical degeneration in Alzheimer's disease].
abstract: OBJECTIVE
  Volumetric analysis of the corpus callosum and hippocampus using MRI in Alzheimer's disease (AD) to evaluate the regional pattern and progression of neocortical neurodegeneration.
  
  
  METHODS
  In subsequent studies we investigated patients with AD and healthy controls. Volumetry was based on MRI-data from a sagittal 3D T1w-gradient echo sequence. The corpus callosum (CC) was measured in a midsagittal slice, and subdivided into 5 subregions. Volumetry of the hippocampus/amygdala-formation (HAF) was performed by segmentation in coronary reoriented slices.
  
  
  RESULTS
  In AD patients we found a significant atrophy in the rostrum und splenium of CC. The atrophy was correlated with the severity of dementia, but no correlation was found with the load of white matter lesions. In comparison with (18)FDG-PET, we found a significant correlation of regional CC-atrophy with the regional decline of cortical glucose metabolism. A ROC-analysis demonstrated no significant differences in the diagnostic accuracy of HAF volumetry and regional CC volumetry of the splenium (region C5) even in mild stages of dementia.
  
  
  CONCLUSIONS
  Regional atrophy of CC can be used as a marker of neocortical degeneration even in early stages of dementia in AD.
authors.affiliation: Institut für Klinische Radiologie, Klinikum der Ludwig-Maximilians-Universität München, Munich. gerda.leinsinger@ikra.med.uni-muenchen.de
authors.forename: G
authors.initials: G
authors.lastname: Leinsinger
authors.forename: S
authors.initials: S
authors.lastname: Teipel
authors.forename: A
authors.initials: A
authors.lastname: Wismüller
authors.forename: C
authors.initials: C
authors.lastname: Born
authors.forename: T
authors.initials: T
authors.lastname: Meindl
authors.forename: W
authors.initials: W
authors.lastname: Flatz
authors.forename: S
authors.initials: S
authors.lastname: Schönberg
authors.forename: J
authors.initials: J
authors.lastname: Pruessner
authors.forename: H
authors.initials: H
authors.lastname: Hampel
authors.forename: M
authors.initials: M
authors.lastname: Reiser
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D000679:Amygdala / Q000473:pathology; D001284:Atrophy; D002986:Clinical Trials as Topic; D003337:Corpus Callosum / Q000473:pathology*; D003937:Diagnosis, Differential; D018450:Disease Progression; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D019579:Neocortex / Q000473:pathology*; D012372:ROC Curve; D012680:Sensitivity and Specificity; D013997:Time Factors; D014055:Tomography, Emission-Computed
vernacular_title: MR-Volumetrie zur Darstellung von Verteilung und zeitlicher Abfolge neokortikaler Degeneration bei Morbus Alzheimer.