Concise synthesis, preparative resolution, absolute configuration determination, and applications of an atropisomeric biaryl catalyst for asymmetric acylation.
A new three-step synthesis and resolution of nucleophilic catalyst 1 suitable for large-scale preparation has been developed, and this catalyst has been shown to be effective for the kinetic resolution and asymmetric desymmetrization of a range of sec-alcohol substrates.
Spivey
Alan C
AC
Department of Chemistry, University of Sheffield, Brook Hill, Sheffield S3 7HF, UK, Pfizer Global Research and Development-LaJolla, 10777 Science Center Drive, San Diego, California 92121, USA. a.c.spivey@imperial.ac.uk
Zhu
Fujiang
F
Mitchell
Mark B
MB
Davey
Stephen G
SG
Jarvest
Richard L
RL