Can tolerogenic dendritic cells help to modulate allo-immune responses in the setting of hematopoietic cell transplantation?
Recent evidence suggests that recipient as well as donor dendritic cell (DC) subsets are implicated in hematopoietic engraftment, graft-vs.-host disease occurrence, immune reconstitution and graft-vs.-leukemia effects observed after allogeneic hematopoietic cell transplantation. Although further data are needed to better understand the precise role of different DC subsets, strategies based on their manipulation to obtain tolerogenic DC can be envisaged. Here, we propose that DC blocked in an immature stage, using immunosuppressive agents, or lymphoid DC can be adequate candidates to control the alloreactive conflict post-allograft.
Fresnay
Stéphanie
S
INSERM E0119, Etablissement Français du Sang Bourgogne Franche-Comté, MEN EA2284, Université de Franche-Comté, Besancon, France.
Garnache-Ottou
Francine
F
Plumas
Joel
J
Seilles
Estelle
E
Tiberghien
Pierre
P
Saas
Philippe
P
D003713:Dendritic Cells / Q000276:immunology* / Q000637:transplantation; D006086:Graft vs Host Disease / Q000276:immunology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007108:Immune Tolerance; D014184:Transplantation, Homologous