title: Echocardiographic parameters of left ventricular systolic and diastolic function in infants, children and adolescents before and after surgical correction of secundum atrial septal defect.
abstract: BACKGROUND
  Left ventricular (LV) dysfunction has been described in adults with secundum atrial septal defect (ASD II) and heart failure (CHF). This anomaly has been rarely regarded as a cause of CHF in pediatric patients with ASD II.
  
  
  OBJECTIVE
  To assess LV systolic and diastolic function in patients with ASD II before and after cardiosurgery as well as to establish the prognostic value of these parameters in infants, children and adolescents with ASD II.
  
  
  METHODS
  LV systolic (LVEF) and diastolic function parameters (E/A, DCT, IVRT) were studied using Doppler echocardiography in 104 patients aged between 1-18 years with ASD II before cardiosurgery and 4 years afterwards. These parameters were compared with similar variables in 150 healthy infants, children and adolescents.
  
  
  RESULTS
  Before surgery LVEF was significantly lower only in infants with ASD II and CHF when compared with healthy controls. Relaxation abnormalities of LV diastolic function were observed before surgery in 40.4% of patients, especially in infants and adolescents with CHF. These disturbances were still present in about 20% of patients after surgery, especially in infants. Before and after surgery both LV and RV end-diastolic volumes were normal in about 6-10% of patients with LV diastolic dysfunction.
  
  
  CONCLUSIONS
  In patients with ASD II and CHF diastolic dysfunction of LV is more common than systolic dysfunction. RV volume overload mainly affects LV diastolic function but it is not the only cause of CHF in patients with ASD II, especially in infants and adolescents. After surgery, normalisation of LV diastolic function is not observed in about 20% of patients with ASD II, especially in those who had CHF before operation. Special monitoring of the circulatory system is necessary in patients with ASD II operated in infancy and adolescence.
authors.affiliation: Department of Pediatric Cardiology and Nephrology, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
authors.forename: Aldona
authors.initials: A
authors.lastname: Siwińska
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Mroziński
authors.forename: Hanna
authors.initials: H
authors.lastname: Górzna-Kamińska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Pawelec-Wojtalik
authors.forename: Michał
authors.initials: M
authors.lastname: Wojtalik
authors.forename: Waldemar
authors.initials: W
authors.lastname: Bobkowski
authors.forename: Jacek
authors.initials: J
authors.lastname: Zachwieja
authors.forename: Janusz
authors.initials: J
authors.lastname: Maciejewski