Determination of an occupational exposure guideline for manganese using the benchmark method.
An occupational risk assessment for manganese (Mn) was performed based on benchmark dose analysis of data from two epidemiological studies providing dose-response information regarding the potential neurological effects of exposure to airborne Mn below the current Occupational Safety and Health Administration (OSHA) Permissible Exposure Level (PEL) of 5 mg Mn/m3. Based on a review of the scientific evidence regarding the toxicity of Mn, it was determined that the most appropriate measure of exposure to airborne Mn for the subclinical effects measured in these studies is recent (rather than historical or cumulative) concentration of Mn in respirable (rather than total) particulate. For each of the studies analyzed, the individual exposure and response data from the original study had been made available by the investigators. From these two studies benchmark concentrations calculated for eight endpoints ranged from 0.09 to 0.27 mg Mn/m3. From our evaluation of these results, and considering the fact that the subtle, subclinical effects represented by the neurological endpoints tested in these studies do not represent material impairment, we believe an appropriate occupational exposure guideline for manganese would be in the range of 0.1 to 0.3 mg Mn/m3, based on the respirable particulate fraction only, and expressed as an 8-hour time-weighted average.
Clewell
Harvey J
HJ
ENVIRON Int'l Corp., Ruston, LA 71270, USA. Hclewell@ENVIRONCorp.com
Lawrence
Gregory A
GA
Calne
Donald B
DB
Crump
Kenny S
KS
D000395:Air Pollutants, Occupational / Q000633:toxicity*; D006801:Humans; D008168:Lung / Q000187:drug effects; D008297:Male; D008345:Manganese / Q000008:administration & dosage / Q000009:adverse effects*; D008452:Maximum Allowable Concentration; D009420:Nervous System / Q000187:drug effects; D019055:No-Observed-Adverse-Effect Level; D016273:Occupational Exposure; D012098:Reproduction / Q000187:drug effects; D018570:Risk Assessment
D000395:Air Pollutants, Occupational; D008345:Manganese