title: Thrombosis prophylaxis in patient populations with a central venous catheter: a systematic review.
abstract: BACKGROUND
  Central venous catheters (CVCs) are used in a wide variety of patients. Associated complications are thrombosis and infection. It is a matter of debate whether thromboprophylaxis is beneficial.
  
  
  METHODS
  We performed a systematic review of 3 different patient populations to render the available information in the literature more accessible to clinical practice: patients receiving parenteral nutrition (PN), patients with cancer, and patients admitted to intensive care units.
  
  
  RESULTS
  Prophylaxis with heparin added to PN was found to give a nonsignificant reduction in the incidence of catheter-related thrombosis (pooled relative risk of randomized studies, 0.77; 95% confidence interval [CI], 0.11-5.48). In cancer patients, both low-dose warfarin and low-molecular-weight heparin significantly reduced the incidence of catheter-related thrombosis (relative risk of randomized studies, 0.25 [95% CI, 0.09-0.70] and 0.10 [95% CI, 0.01-0.71], respectively). So far, intensive care patients have hardly been studied with respect to thromboprophylaxis and the incidence of CVC thrombosis. Any effect of the type of catheter could not be established because of small numbers. There was no apparent increase in bleeding events with prophylactic anticoagulation in patients with CVCs.
  
  
  CONCLUSIONS
  In the small number of patients studied, the addition of heparin to PN did not significantly decrease the risk of catheter-related thrombosis, whereas warfarin and dalteparin did decrease the thrombosis risk in cancer patients with CVCs. There is no apparent increase in bleeding events with prophylactic anticoagulants in patients with CVCs.
authors.affiliation: Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. c.p.klerk@amc.uva.nl
authors.forename: Clara P W
authors.initials: CP
authors.lastname: Klerk
authors.forename: Susanne M
authors.initials: SM
authors.lastname: Smorenburg
authors.forename: Harry R
authors.initials: HR
authors.lastname: Büller
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D016638:Critical Illness / Q000628:therapy; D017985:Dalteparin / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D007362:Intensive Care Units; D009369:Neoplasms / Q000188:drug therapy; D010288:Parenteral Nutrition; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D020246:Venous Thrombosis / Q000209:etiology / Q000517:prevention & control*; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D000970:Antineoplastic Agents; D014859:Warfarin; D006493:Heparin; D017985:Dalteparin