title: Measurement of free fatty acids in cerebrospinal fluid from patients with hemorrhagic and ischemic stroke.
abstract: Free fatty acid (FFA) concentrations in cerebrospinal fluid (CSF) from patients with ischemic and hemorrhagic stroke (n=25) and in contemporary controls (n=73) were examined using HPLC. Concentrations of CSF FFAs from ischemic and hemorrhagic stroke patients obtained within 48 h of the insult were significantly greater than in control patients. Higher concentrations of polyunsaturated fatty acids (PUFAs) in CSF obtained within 48 h of insult were associated with significantly lower (P<0.05) admission Glasgow Coma Scale scores and worse outcome at the time of hospital discharge, using the Glasgow Outcome Scale (P<0.01).
authors.affiliation: Department of Neurosurgery, Wayne State University School of Medicine, UHC-6E, 4201 St. Antoine, Detroit, MI 48201, USA.
authors.forename: J G
authors.initials: JG
authors.lastname: Pilitsis
authors.forename: W M
authors.initials: WM
authors.lastname: Coplin
authors.forename: M H
authors.initials: MH
authors.lastname: O'Regan
authors.forename: J M
authors.initials: JM
authors.lastname: Wellwood
authors.forename: F G
authors.initials: FG
authors.lastname: Diaz
authors.forename: M R
authors.initials: MR
authors.lastname: Fairfax
authors.forename: D B
authors.initials: DB
authors.lastname: Michael
authors.forename: J W
authors.initials: JW
authors.lastname: Phillis
mesh_terms: D002851:Chromatography, High Pressure Liquid; D018450:Disease Progression; D005230:Fatty Acids, Nonesterified / Q000134:cerebrospinal fluid* / Q000145:classification; D015600:Glasgow Coma Scale; D006801:Humans; D007511:Ischemia / Q000134:cerebrospinal fluid*; D018709:Statistics, Nonparametric; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid*
chemical_list: D005230:Fatty Acids, Nonesterified