title: Effect of medroxyprogesterone acetate on the efficiency of an oral protein-rich nutritional support in HIV-infected patients.
abstract: We have examined the effect of a medroxyprogesterone therapy in HIV-infected patients under appropriate nutrition for anabolism. The experiments were performed on 12 men (mean age 40 y), HIV seropositive but free of any clinically active opportunistic infection for at least one month. The patients underwent a 2-week baseline diet period (1.2 g protein x kg(-1) body weight (BW) x d(-1)) and then a 5-week experimental period with again the baseline diet in conjunction with supplements including Tonexis HP (0.7 g protein x kg(-1) BW) x d(-1)), L-threonine (0.018 g x kg(-1) BW x d(-1)) and L-methionine (0.013 g x kg(-1) BW x d(-1)). Indeed HIV-infected patients showed deficiencies in these amino acids. They were randomly divided into groups I and II under double-blinded condition. Group II was given medroxyprogesterone acetate (0.4 g x d(-1)) during the last 3 weeks whereas group I received a placebo. All the patients significantly increased their body weight (P < 0.05) during the experimental periods. Those under medroxyprogesterone tended to show a higher but not significant weight gain (+3.1 +/- 1.0 kg in group II and +1.9 +/- 0.3 kg in group I). Blood free amino acids were used as rough indicators of amino acid utilization and were analyzed prior and during acute 150 min intravenous infusion of a complete glucose-amino acid mixture. This test was done before and at the end of the experimental periods. Basal essential blood free amino acids were similar in the two groups and did not change during the experimental period. Most essential amino acids increased following glucose-amino acid infusions. The incremental increase was of less magnitude after the experimental period than before when medroxyprogesterone was present (P < 0.05 for valine, leucine, lysine, threonine and methionine). This was not the case in the absence of the hormone. We concluded that medroxyprogesterone might improve the efficacy of an oral protein-rich nutritional support in HIV-infected patients.
authors.affiliation: Unité de Nutrition et Métabolisme Protéique, INRA, Centre de Clermont-Ferrand-Theix, 63122 Saint-Genès-Champanelle, France.
authors.forename: Cécile
authors.initials: C
authors.lastname: Rochon
authors.forename: Magali
authors.initials: M
authors.lastname: Prod'homme
authors.forename: Henri
authors.initials: H
authors.lastname: Laurichesse
authors.forename: Igor
authors.initials: I
authors.lastname: Tauveron
authors.forename: Michèle
authors.initials: M
authors.lastname: Balage
authors.forename: Florence
authors.initials: F
authors.lastname: Gourdon
authors.forename: Olivier
authors.initials: O
authors.lastname: Baud
authors.forename: Christine
authors.initials: C
authors.lastname: Jacomet
authors.forename: Sylvie
authors.initials: S
authors.lastname: Jouvency
authors.forename: Gérard
authors.initials: G
authors.lastname: Bayle
authors.forename: Claude
authors.initials: C
authors.lastname: Champredon
authors.forename: Philippe
authors.initials: P
authors.lastname: Thieblot
authors.forename: Jean
authors.initials: J
authors.lastname: Beytout
authors.forename: Jean
authors.initials: J
authors.lastname: Grizard
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000008:administration & dosage / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D004044:Dietary Proteins / Q000008:administration & dosage*; D004311:Double-Blind Method; D005947:Glucose / Q000008:administration & dosage; D015658:HIV Infections / Q000628:therapy*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D017258:Medroxyprogesterone Acetate / Q000627:therapeutic use*; D018529:Nutritional Support; D010919:Placebos; D014508:Urea / Q000097:blood; D015430:Weight Gain
chemical_list: D000596:Amino Acids; D001786:Blood Glucose; D001798:Blood Proteins; D004044:Dietary Proteins; D007328:Insulin; D010919:Placebos; D014508:Urea; D017258:Medroxyprogesterone Acetate; D005947:Glucose