title: A new superfamily of protein-O-fucosyltransferases, alpha2-fucosyltransferases, and alpha6-fucosyltransferases: phylogeny and identification of conserved peptide motifs.
abstract: The presence of three conserved peptide motifs shared by alpha2-fucosyltransferases, alpha6-fucosyltransferases, the protein-O-fucosyltransferase family 1 (POFUT1) and a newly identified protein-O-fucosyltransferase family 2 (POFUT2), together with evidence that the present genes encoding for these enzymes have originated from a common ancestor by duplication and divergent evolution, suggests that they constitute a new superfamily of fucosyltransferases.
authors.affiliation: Unité de Glycobiologie et Signalisation Cellulaire, INSERM U504, GDR CNRS 2590, Université de Paris Sud XI, 16 Ave Paul Vaillant-Couturier, 94807 Villejuif Cedex France.
authors.forename: Ivan
authors.initials: I
authors.lastname: Martinez-Duncker
authors.forename: Rosella
authors.initials: R
authors.lastname: Mollicone
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Candelier
authors.forename: Christelle
authors.initials: C
authors.lastname: Breton
authors.forename: Rafael
authors.initials: R
authors.lastname: Oriol
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D005647:Fucosyltransferases / Q000737:chemistry* / Q000145:classification / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid
chemical_list: D005647:Fucosyltransferases