Finding specificity within a conserved interaction site.
Recently developed approaches to generate drugs that regulate hormone-induced gene activation focus on modulating the interaction of nuclear receptors with coactivators. A study by Geistlinger and Guy demonstrates the feasibility of this approach and provides surprising evidence for specificity within the conserved nuclear receptor:coactivator interaction surface.
Darimont
Beatrice D
BD
Institute of Molecular Biology, University of Oregon, Eugene, OR 97405, USA.
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D016384:Consensus Sequence; D016503:Drug Delivery Systems; D006801:Humans; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism
D009687:Nuclear Proteins; D018160:Receptors, Cytoplasmic and Nuclear