title: [Relative contraindication of latanoprost in iris tumors with secondary glaucoma].
abstract: BACKGROUND
  Melanocytic iris tumors are often benign and merely require regular follow-up. Evident growth, increasing pigmentation and secondary glaucoma, however, are possible signs of a malignant transformation.
  
  
  METHODS
  We present a 34-year-old male patient showing a localized, mildly prominent hyperpigmentation of the right iris expanding over 2 h. The lesion had been known since childhood and increasing intraocular pressure (IOP) was treated with timolole, dipivefrin and finally with latanoprost.
  
  
  RESULTS
  The patient was seen for the first time at our hospital 4 years previously, presenting an IOP of 28-30 mmHg of the right eye. The tumor had developed marked heterochromia and a nodular prominent surface, the chamber angle was partly closed and completely hyperpigmented. The ciliary body was not affected by the tumor and standard ultrasound revealed a maximum thickness of 1.2 mm. Over the last 4 years, IOP and heterochromia had increased but without growth of the tumor. An excisional biopsy of the prominent portion was refused by the patient.
  
  
  CONCLUSIONS
  The melanocytic iris tumor described shows malignant characteristics such as progressive heterochromia and secondary glaucoma. However, increasing iris pigmentation can also be caused by topical application of latanoprost. With the evidence of absent tumor growth, there is no reason to suggest malignant degeneration. Generally, in iris naevi or tumors requiring regular follow-up, application of latanoprost should be avoided in order not to conceal the alteration of pigmentation as possible malignant conversion.
authors.affiliation: Augenklinik der Ludwig-Maximilians-Universität, Munich. sfroehli@ak-i.med.uni-muenchen.de
authors.forename: S J
authors.initials: SJ
authors.lastname: Fröhlich
authors.forename: A J
authors.initials: AJ
authors.lastname: Mueller
authors.forename: A
authors.initials: A
authors.lastname: Kampik
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000009:adverse effects / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced* / Q000473:pathology; D000075202:Contraindications; D018450:Disease Progression; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007498:Iris / Q000473:pathology; D015811:Iris Neoplasms / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D000077338:Latanoprost; D008297:Male; D008545:Melanoma / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D011461:Prostaglandins F, Synthetic / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost
vernacular_title: Relative Kontraindikation von Latanoprost bei Iristumor mit Sekundärglaukom.