title: Diagnostic approach in patients with symmetric imaging lesions of the deep gray nuclei.
abstract: BACKGROUND
  Selective insult to brain deep gray matter nuclei is uncommon, may be congenital or acquired, acute or chronic, and varied in etiology. Determining the etiology relies on history, clinical presentation, laboratory investigations, and lesion pattern on Neuroimaging.
  
  
  RESULTS
  We review the differential diagnosis and clinical, laboratory and neuroimaging pattern of conditions that manifest with lesions of deep gray matter nuclei in the context of representative case studies.
  
  
  CONCLUSIONS
  While presentations may vary in individual patients, the essentials of history, clinical examination, laboratory evaluation,and neuroimaging lesion pattern can be efficiently directed to differentiate the various etiologies of deep gray matter nuclei lesions. In this review we focus on the etiologic classification and diagnostic approach to acute and chronic conditions that manifest on neuroimaging with bilateral symmetric lesions of deep gray matter nuclei.
authors.affiliation: Department of Neurology, Hartford Hospital, Connecticut Children's Medical Center/University of Connecticut School of Medicine, Hartford, CT, USA. NERVLINE@AOL.COM
authors.forename: Pasquale F
authors.initials: PF
authors.lastname: Finelli
authors.forename: Francis J
authors.initials: FJ
authors.lastname: DiMario
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000175:diagnosis*; D002648:Child; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D016548:Prosencephalon / Q000000981:diagnostic imaging* / Q000473:pathology*; D011859:Radiography