title: Human adipose cells as candidates in defense and tissue remodeling phenomena.
abstract: Macrophages are part of the immunity defense mechanism via oxidative burst and phagocytosis. They are also involved in tissue remodeling via cytokine secretion and apoptotic body clearance. Previously, we demonstrated that adipose cells and macrophages share some of their features and functions. Our aim was to further test this hypothesis in humans. We first demonstrated that human preadipocytes exhibit phagocytosis of yeast, this effect being specific compared to another fibroblastic cell type, the skin fibroblast. Furthermore, as in rodents, human preadipocytes exhibit anti-microbial activity. Finally, for the first time, it was shown that these cells were able to phagocyte apoptotic lymphocytes. Altogether, these data suggest an active involvement of fat cells in host defense and tissue remodeling, which might play an important role at the level of the whole organism due to the large amount of adipose tissue. This gives support for some observations linking obesity or cachexia to immunological disorders.
authors.affiliation: UMR 5018 CNRS-UPS, Institut Louis Bugnard, CHU Rangueil, Bat L1, 31403 Toulouse, France.
authors.forename: C
authors.initials: C
authors.lastname: Saillan-Barreau
authors.forename: B
authors.initials: B
authors.lastname: Cousin
authors.forename: M
authors.initials: M
authors.lastname: André
authors.forename: P
authors.initials: P
authors.lastname: Villena
authors.forename: L
authors.initials: L
authors.lastname: Casteilla
authors.forename: L
authors.initials: L
authors.lastname: Pénicaud
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000502:physiology*; D000273:Adipose Tissue / Q000166:cytology*; D017209:Apoptosis; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D019169:Jurkat Cells; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis; D013234:Stem Cells / Q000502:physiology