title: Thrombin, inflammation, and cardiovascular disease: an epidemiologic perspective.
abstract: The exploration of coagulation led to identifying inflammation as a major factor in arterial disease throughout life. "Integrative molecular physiology" reflects our emerging understanding of how coagulation and inflammation integrate with one another, in both normal physiology and in pathophysiology. Our own responses to environmental challenge provide much of the damage that cumulatively results in chronic cardiovascular disease. Only by intervening in exquisitely precise ways can we hope to effectively and safely modify the course of lifelong chronic diseases, such as atherosclerosis.
authors.affiliation: Laboratory for Clinical Biochemistry Research, College of Medicine, University of Vermont, Colchester, VT 05446, USA. russell.tracy@uvm.edu
authors.forename: Russell P
authors.initials: RP
authors.lastname: Tracy
mesh_terms: D001161:Arteriosclerosis / Q000150:complications; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D007249:Inflammation; D024821:Metabolic Syndrome / Q000150:complications; D012307:Risk Factors; D013917:Thrombin / Q000502:physiology; D013927:Thrombosis / Q000150:complications
chemical_list: D013917:Thrombin