Effect of treatment for sexually transmitted disease on HIV transmission.
The rapid increase in the worldwide prevalence of HIV infection and sexually transmitted diseases (STDs) has prompted research into the effect of STDs on HIV transmission as well as that of STD treatment interventions on HIV incidence. There is conclusive evidence that STDs act as co-factors for HIV transmission but STD treatment intervention studies have demonstrated contradictory results. Current evidence on the effect of STDs on HIV transmission and community-based randomised controlled trials of STD interventions in Uganda and Tanzania is discussed. Further prospective, randomised, community-based STD intervention studies focusing on the treatment of bacterial STDs and herpes simplex virus (HSV) infection are urgently needed in order to clarify the current uncertainty.
Browne
Rita
R
St Stephen's Centre, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK.
Nwokolo
Nneka
N
Boag
Fiona
F
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D018562:Disease Transmission, Infectious / Q000517:prevention & control; D005260:Female; D006678:HIV / Q000254:growth & development*; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology / Q000635:transmission*; D006561:Herpes Simplex / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D013587:Syphilis / Q000150:complications* / Q000188:drug therapy; D013636:Tanzania / Q000453:epidemiology; D014454:Uganda / Q000453:epidemiology
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents