title: Disodium cromoglycate prevents ileum hyperreactivity to histamine in Toxocara canis-infected guinea pigs.
abstract: The aim of this study was to investigate whether Toxocara canis infection in guinea pigs provokes changes in ileum responsiveness to histamine. Ileum segments from control and T. canis-infected groups were placed at isometric conditions and submitted to various doses of histamine. No changes were observed between controls and T. canis-infected groups at days 3, 6 and 12 after infection. However, at days 18 and 24 after infection, there was a significant increase in ileum responsiveness to histamine in T. canis-infected group. Pre-incubation of ileum segments with 1mgml(-1) disodium cromoglycate (DSCG) prevented the increased responsiveness to histamine in T. canis-infected guinea pigs and did not affect ileum contractility in non-infected animals. These results indicate that T. canis-infected guinea pigs develop increased intestinal responsiveness to histamine and that DSCG prevents alterations in smooth-muscle contractility.
authors.affiliation: Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Cafe s/no, Ribeirão Preto, 14040-903, São Paulo, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Sá-Nunes
authors.forename: A P
authors.initials: AP
authors.lastname: Corrado
authors.forename: M D
authors.initials: MD
authors.lastname: Baruffi
authors.forename: L H
authors.initials: LH
authors.lastname: Faccioli
mesh_terms: D000818:Animals; D004205:Cromolyn Sodium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006633:Histamine Antagonists; D007082:Ileum / Q000187:drug effects / Q000503:physiopathology*; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000187:drug effects; D017166:Toxocara canis; D014120:Toxocariasis / Q000469:parasitology / Q000503:physiopathology*
chemical_list: D006633:Histamine Antagonists; D004205:Cromolyn Sodium