title: Feto-maternal alloimmune thrombocytopenia due to HPA-5b incompatibility: a case report.
abstract: Feto-maternal alloimmune thrombocytopenia (FMAIT) results from the maternal production of antibodies against fetal platelets with incompatible antigens inherited from the father. We present a case where this condition was diagnosed prenatally without previously affected siblings. The severe fetal thrombocytopenia was due to anti-HLA-5b maternal alloantibodies. This was treated successfully by intravenous immunoglobulins. Our case reflects that FMAIT due to anti-HPA-5b may be severe and may be corrected successfully with intravenous immunoglogulins.
authors.affiliation: Department of Obstetrics and Gynaecology, Hôpital Robert Ballanger, Aulnay-Sous-Bois, Paris, France. rherrero@club-internet.fr
authors.forename: Rafael J M
authors.initials: RJ
authors.lastname: Herrero
authors.forename: Yvon
authors.initials: Y
authors.lastname: Chitrit
authors.forename: Patrick
authors.initials: P
authors.lastname: Caubel
authors.forename: Daniel
authors.initials: D
authors.lastname: Lusina
mesh_terms: D000328:Adult; D000462:Algeria / Q000208:ethnology; D016824:Antigens, Human Platelet / Q000276:immunology*; D002585:Cesarean Section; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000276:immunology*; D005602:France; D005865:Gestational Age; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007518:Isoantibodies / Q000276:immunology*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013921:Thrombocytopenia / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*
chemical_list: C055973:5b alloantigen, human; D016824:Antigens, Human Platelet; D016756:Immunoglobulins, Intravenous; D007518:Isoantibodies