title: A bioactive bone cement containing Bis-GMA resin and A-W glass-ceramic as an augmentation graft material on mandibular bone.
abstract: The potential of a bioactive bone cement (BABC) as an onlay graft material for the mandible with and without the periosteum was investigated in rabbits. Its matrix consists of bisphenol-alpha-glycidyl methacrylate (Bis-GMA) and triethylene-glycol dimetacrylate (TEGDMA) and its filler is silane-treated CaO-SiO2-P2O5-MgO-CaF2 glass (A-W glass-ceramic) powder. The BABC was pasted onto the mandible under the periosteum in Group 1, and onto the mandible with the periosteum removed in Group 2 and allowed to set in situ. In both groups, the cement-bone interface was filled by new bone at 4, 12 and 48 weeks, and bone grew from adjacent bone tissue into the cement-soft tissue interface at 12 and 48 weeks. There were no differences in the rate of bone formation between the groups. The shearing strength increased progressively from 0.25+/-0.10 MPa (mean+/-SD) at week 1 to 7.98+/-0.62 MPa at week 48. The results suggest that the BABC has good handling properties, a high bonding strength and good biocompatibility, and that it has potential for clinical application as a substitute material for autogenous bone transplantation.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Ishikawa, Japan. I-kkk@kanazawa-med.ac.jp
authors.forename: Kazuma
authors.initials: K
authors.lastname: Fujimura
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Bessho
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Okubo
authors.forename: Natsuki
authors.initials: N
authors.lastname: Segami
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Iizuka
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D017438:Bisphenol A-Glycidyl Methacrylate / Q000494:pharmacology; D001843:Bone Cements / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000494:pharmacology; D002516:Ceramics / Q000494:pharmacology; D003799:Dental Stress Analysis; D008297:Male; D008334:Mandible / Q000601:surgery; D010521:Periosteum / Q000601:surgery; D011092:Polyethylene Glycols / Q000494:pharmacology; D011109:Polymethacrylic Acids / Q000494:pharmacology; D011817:Rabbits; D019279:Resin Cements / Q000494:pharmacology; D033081:Shear Strength
chemical_list: D001843:Bone Cements; D018786:Bone Substitutes; D011109:Polymethacrylic Acids; D019279:Resin Cements; C020946:triethylene glycol dimethacrylate; D011092:Polyethylene Glycols; D017438:Bisphenol A-Glycidyl Methacrylate; C023506:Glass ceramics