title: [Comparison of RR-formoterol with rac-formoterol in bronchodilating effect on human bronchus].
abstract: To compare the bronchodilating effect of RR-formoterol (RR-FMT) with that of racemic formoterol (rac-FMT) on human bronchus.
  
  
  
  Human bronchial spiral strips (2 - 4 mm internal diameter,15 mm length) were suspended in tissue baths under resting tension of 1.0 g. The changes of tension induced by RR-FMT and rac-FMT(10 pmol x L(-1) - 3.2 micromol x L(-1)) in a cumulative concentration manner were studied under resting tension conditions or precontraction with carbamylcholine (10 micromol x L(-1)) or histamine(100 micromol x L(-1)) in human bronchus.
  
  
  
  The bronchodilating effect of RR-FMT was more potent than that of rac-FMT under resting condition(P<0.05). RR-FMT and rac-FMT reversed histamine or carbamylcholine-induced contraction, and the bronchodilating effect of RR-FMT was more potent than that of rac-FMT (P<0.05).
  
  
  
  The bronchodilating effect of RR-FMT is more potent than that of rac-FMT in both the resting condition and carbamylcholine or histamine-induced contraction in human bronchus in vitro.
authors.affiliation: Zhejiang Respiratory Drugs Research Laboratory of State Food and Drug Administration of China, College of Medicine, Zhejiang University, Hangzhou 310031, China.
authors.forename: Ji-de
authors.initials: JD
authors.lastname: Xu
authors.forename: Qiang-min
authors.initials: QM
authors.lastname: Xie
authors.forename: Ji-qiang
authors.initials: JQ
authors.lastname: Chen
authors.forename: Ru-lian
authors.initials: RL
authors.lastname: Bian
mesh_terms: D000368:Aged; D001980:Bronchi / Q000187:drug effects* / Q000502:physiology; D001993:Bronchodilator Agents / Q000494:pharmacology*; D002217:Carbachol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004983:Ethanolamines / Q000494:pharmacology*; D000068759:Formoterol Fumarate; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D013237:Stereoisomerism
chemical_list: D001993:Bronchodilator Agents; D004983:Ethanolamines; D006632:Histamine; D002217:Carbachol; D000068759:Formoterol Fumarate