Measurement of free fatty acids in cerebrospinal fluid from patients with hemorrhagic and ischemic stroke.
Free fatty acid (FFA) concentrations in cerebrospinal fluid (CSF) from patients with ischemic and hemorrhagic stroke (n=25) and in contemporary controls (n=73) were examined using HPLC. Concentrations of CSF FFAs from ischemic and hemorrhagic stroke patients obtained within 48 h of the insult were significantly greater than in control patients. Higher concentrations of polyunsaturated fatty acids (PUFAs) in CSF obtained within 48 h of insult were associated with significantly lower (P<0.05) admission Glasgow Coma Scale scores and worse outcome at the time of hospital discharge, using the Glasgow Outcome Scale (P<0.01).
Pilitsis
J G
JG
Department of Neurosurgery, Wayne State University School of Medicine, UHC-6E, 4201 St. Antoine, Detroit, MI 48201, USA.
Coplin
W M
WM
O'Regan
M H
MH
Wellwood
J M
JM
Diaz
F G
FG
Fairfax
M R
MR
Michael
D B
DB
Phillis
J W
JW
D002851:Chromatography, High Pressure Liquid; D018450:Disease Progression; D005230:Fatty Acids, Nonesterified / Q000134:cerebrospinal fluid* / Q000145:classification; D015600:Glasgow Coma Scale; D006801:Humans; D007511:Ischemia / Q000134:cerebrospinal fluid*; D018709:Statistics, Nonparametric; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid*
D005230:Fatty Acids, Nonesterified