De novo synthesis of two new cytotoxic tiazofurin analogues with modified sugar moieties.
A divergent synthesis of two novel tiazofurin analogues, 2-(3-deoxy-3-fluoro-beta-D-xylofuranosyl)thiazole-4-carboxamide (2) and 2-(3-acetamido-3-deoxy-beta-D-xylofuranosyl)thiazole-4-carboxamide (3), has been achieved starting from D-glucose. Both nucleoside analogues were evaluated for their in vitro cytotoxicity against several human leukaemia and solid tumour cell lines.
Popsavin
Mirjana
M
Department of Chemistry, Faculty of Sciences, University of Novi Sad, Trg D. Obradovića 3, 21000 Novi Sad, Serbia and Montenegro, Yugoslavia. popsavin@ih.ns.ac.yu
Torović
Ljilja
L
Kojić
Vesna
V
Bogdanović
Gordana
G
Spaić
Sasa
S
Popsavin
Velimir
V
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000633:toxicity*; D002460:Cell Line; D045744:Cell Line, Tumor; D005947:Glucose / Q000138:chemical synthesis / Q000633:toxicity; D006801:Humans; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000633:toxicity*
D000970:Antineoplastic Agents; D012254:Ribavirin; D005947:Glucose; C033706:tiazofurin