title: Four-year results following treatment of intrabony periodontal defects with an enamel matrix protein derivative: a report of 46 cases.
abstract: Treatment of intrabony periodontal defects with an enamel matrix derivative (EMD) has been shown to predictably enhance periodontal regeneration. The aim of the present study was to evaluate the 4-year results following treatment of intrabony defects with EMD. Thirty-three patients with a total of 46 intrabony defects were treated. Each patient exhibited at least one intrabony defect with a probing depth > or = 6 mm as identified by probing and on radiographs. The following clinical parameters were evaluated prior to and 1 and 4 years after treatment: probing depth, recession of the gingival margin, and clinical attachment level. The primary outcome variable was clinical attachment. Mean probing depth was reduced from 8.1 +/- 1.8 mm to 3.8 - +/-.2 mm at 1 year and to 4.0 +/- 1.2 mm at 4 years. No statistically significant differences were found between the mean probing depth 1 and 4 years postoperative. At 1 year, the mean recession increased from 1.9 +/- 1.5 mm to 3.2 +/- 1.8 mm; at 4 years, it was 2.8 +/- 1.2 mm, a statistically significant improvement compared to the 1-year results, but still significantly increased compared to the baseline. The mean attachment level changed from 10.0 +/- 2.4 mm to 7.0 +/- 2.1 mm at 1 year and 6.8 +/- 1.9 mm at 4 years (no statistically significant difference). The clinical improvements obtained following treatment with EMD can be maintained over a 4-year period.
authors.affiliation: Section of Periodontology, Department of Conservative Dentistry, Johannes Gutenberg University, Mainz, Germany. anton.sculean@gmx.de
authors.forename: Anton
authors.initials: A
authors.lastname: Sculean
authors.forename: Giovanni Carlo
authors.initials: GC
authors.lastname: Chiantella
authors.forename: Asta
authors.initials: A
authors.lastname: Miliauskaite
authors.forename: Michel
authors.initials: M
authors.lastname: Brecx
authors.forename: Nicole Birgit
authors.initials: NB
authors.lastname: Arweiler
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000145:classification; D006801:Humans; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000145:classification; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification; D011859:Radiography; D013524:Surgical Flaps; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D003746:Dental Enamel Proteins; C109069:enamel matrix proteins