title: [Population-based study of human papillomavirus infection in high-risk area for cervical cancer in Shanxi Province, China].
abstract: OBJECTIVE
  To investigate the prevalence of oncogenic type of human papillomavirus (HPV) infection and identify the high risk population for conducting immuno/chemoprevention of cervical cancer.
  
  
  METHODS
  All married women aged 30 to 50 with no history of hysterectomy, pelvic radiation and non-pregnant from certain villages of Xiangyuan and Yangcheng County were invited. This study was conducted through two phases. In phase one, subjects sampled the vaginal secretions using the collectors after signing the informed consent. And physicians sampled exfoliated cells from cervix in the phase two. All the specimens were tested with the Hybrid Capture 2 test. The data was managed and analyzed by VFP and SPSS software.
  
  
  RESULTS
  There were 9,683 women participated in this study. Local women welcomed this study and population compliance rate was 75.4%. In tested population, we found 2,666 subjects of HPV DNA positive and HPV prevalence was 27.5%. The rates of different age group were 24.5% (30-34 yrs), 27.4% (35-39 yrs), 28.2% (40-44 yrs), 27.4% (45-50 yrs) respectively and had no significant differences (P = 0.604). The rates were slightly increased with the higher education level and had no differences (P = 0.106). The rate in mountain areas was higher than that in half-mountain areas (P = 0.001).
  
  
  CONCLUSIONS
  The prevalence of HPV infection is indeed high in this region. Local women and health professionals welcome the activities of cervical cancer screening and prevention. It is an emergent task to improve their sanitary condition and prevent them from cervical cancer in these women. A women health cohort is established successfully among high HPV exposed women in rural China. The extensive biologic specimen repository has been successfully established to simultaneously study the etiology, early detection, and immuno/chemoprevention of cervical cancer.
authors.affiliation: Department of Epidemiology, Cancer Institute, CAMS and PUMC, Beijing 100021, China.
authors.forename: Yan-hong
authors.initials: YH
authors.lastname: Shen
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Man-ni
authors.initials: MN
authors.lastname: Huang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Xi-xia
authors.initials: XX
authors.lastname: Wang
authors.forename: Fang-hui
authors.initials: FH
authors.lastname: Zhao
authors.forename: Shu-min
authors.initials: SM
authors.lastname: Li
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Ling-ying
authors.initials: LY
authors.lastname: Wu
authors.forename: Shou-de
authors.initials: SD
authors.lastname: Rong
authors.forename: Wen-hua
authors.initials: WH
authors.lastname: Zhang
authors.forename: Sheng-da
authors.initials: SD
authors.lastname: Ren
authors.forename: Rui-de
authors.initials: RD
authors.lastname: Huang
authors.forename: You-lin
authors.initials: YL
authors.lastname: Qiao
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000517:prevention & control; D015995:Prevalence; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000517:prevention & control; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology*; D014626:Vaginal Smears
chemical_list: D004279:DNA, Viral