Toxic effect of Herniaria cinerea DC. on the stomach, intestine, lung, and kidney of rats.
The toxic effect of the butanolic extract of Herniaria cinerea DC., a plant used traditionally to cure renal stones, has been tested by oral administration on Wistar male rats. The extract causes bloody diarrhea and respiratory troubles. The study of the histopathological lesions in the stomach, intestine, lung, and kidney revealed an ulcerous effect on the digestive tract and alveolar destruction. In the kidney, we observed total tubular necrosis with hemorrhage.
Sokar
Z
Z
Laboratory of Medicinal Plants and Phytochemistry, Department of Biology, Faculty of Sciences, Semlalia P.O. Box 2390, Marrakesh 40000, Morocco.
Gadhi
C A
CA
Benharref
A
A
Jana
M
M
D000818:Animals; D029748:Caryophyllaceae / Q000737:chemistry / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D007422:Intestines / Q000187:drug effects* / Q000473:pathology; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009336:Necrosis; D010936:Plant Extracts / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects* / Q000473:pathology
D010936:Plant Extracts