Alterations of L- and M-cone driven ERGs in cone and cone-rod dystrophies.
To study the L- and M-cone pathways and their interactions in patients with cone and cone-rod dystrophies, ERG responses were measured to stimuli which modulated exclusively the L- or the M-cones, or the two simultaneously. The L- and M-cone driven ERG amplitudes were considerably reduced in the patients. The mean phases of the L-cone driven ERGs in the patients lagged those of normals significantly, whereas the mean M-cone driven ERGs were significantly phase advanced resulting in a substantial phase difference between the two ERG responses. These phase changes in the L- and M-cone driven responses in the patients cannot be detected with standard ERG techniques.
Scholl
Hendrik P N
HP
Department of Pathophysiology of Vision and Neuroophthalmology, University Eye Hospital, 72076 Tübingen, Germany.
Kremers
Jan
J
D004596:Electroretinography; D006801:Humans; D010775:Photic Stimulation; D011601:Psychophysics; D017949:Retinal Cone Photoreceptor Cells / Q000503:physiopathology*; D012174:Retinitis Pigmentosa / Q000503:physiopathology*