Relay and control of abscisic acid signaling.
Insights into the signal transduction of the phytohormone abscisic acid (ABA) have unfolded dramatically in the past few years and reveal an unanticipated complexity. Knockout lines and RNA-interference technology, together with protein interaction analyses, have been used to identify many of the cellular components that regulate or modulate ABA responses. ABA signaling is characterized by a plethora of intracellular messengers. This may reflect the function of ABA in integrating several stress responses and antagonizing pathways via cross-talk, but it hampers the establishment of a unifying concept. Transcriptome analyses have unraveled more than a thousand genes that are differentially regulated by ABA, and these ABA-mediated changes in gene expression translate to major changes in proteome expression. ABA-induced mechanisms that re-adjust cellular protein expression are just surfacing. ABA-response-specific transcription factors have a well-established function in that process and, recently, it has also become clear that phytohormone signaling enforces a sophisticated interference with protein expression at the posttranscriptional level. This interference includes both targeted proteolysis and the regulation of the translation of specific mRNAs by RNA-binding proteins.
Himmelbach
Axel
A
Lehrstuhl für Botanik, Technische Universität München, Biologikum Weihenstephan, Am Hochanger 4, 85354 Freising, Germany.
Yang
Yi
Y
Grill
Erwin
E
D000040:Abscisic Acid / Q000494:pharmacology*; D010944:Plants / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D025941:Protein Interaction Mapping; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D014157:Transcription Factors; D000040:Abscisic Acid