Feto-maternal alloimmune thrombocytopenia due to HPA-5b incompatibility: a case report.
Feto-maternal alloimmune thrombocytopenia (FMAIT) results from the maternal production of antibodies against fetal platelets with incompatible antigens inherited from the father. We present a case where this condition was diagnosed prenatally without previously affected siblings. The severe fetal thrombocytopenia was due to anti-HLA-5b maternal alloantibodies. This was treated successfully by intravenous immunoglobulins. Our case reflects that FMAIT due to anti-HPA-5b may be severe and may be corrected successfully with intravenous immunoglogulins.
Herrero
Rafael J M
RJ
Department of Obstetrics and Gynaecology, Hôpital Robert Ballanger, Aulnay-Sous-Bois, Paris, France. rherrero@club-internet.fr
Chitrit
Yvon
Y
Caubel
Patrick
P
Lusina
Daniel
D
D000328:Adult; D000462:Algeria / Q000208:ethnology; D016824:Antigens, Human Platelet / Q000276:immunology*; D002585:Cesarean Section; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000276:immunology*; D005602:France; D005865:Gestational Age; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007518:Isoantibodies / Q000276:immunology*; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013921:Thrombocytopenia / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*
C055973:5b alloantigen, human; D016824:Antigens, Human Platelet; D016756:Immunoglobulins, Intravenous; D007518:Isoantibodies