Old livers--C/EBPalpha meets new partners.
The aging liver loses the ability to proliferate after partial hepatic resections. We have recently found that, in liver, aging switches C/EBPalpha from inhibition of Cdks to repression of E2F, the pathway that normally operates in adipose tissues. This switch causes a loss of proliferative response in old livers because of an inability to induce E2F target genes after partial hepatectomy.
Timchenko
Nikolai A
NA
Huffington Center on Aging and Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA. nikolait@bcm.tmc.edu
D017667:Adipocytes / Q000378:metabolism; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D022763:CCAAT-Enhancer-Binding Protein-alpha / Q000378:metabolism*; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D006498:Hepatectomy; D022781:Hepatocytes / Q000378:metabolism; D008099:Liver / Q000473:pathology / Q000502:physiology; D008115:Liver Regeneration / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D014157:Transcription Factors / Q000378:metabolism*
D022763:CCAAT-Enhancer-Binding Protein-alpha; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D014157:Transcription Factors