title: GenePath: a system for inference of genetic networks and proposal of genetic experiments.
abstract: A genetic network is a formalism that is often used in biology to represent causalities and reason about biological phenomena related to genetic regulation. We present GenePath, a computer-based system that supports the inference of genetic networks from a set of genetic experiments. Implemented in Prolog, GenePath uses abductive inference to elucidate network constraints based on background knowledge and experimental results. Additionally, it can propose genetic experiments that may further refine the discovered network and establish relations between genes that could not be related based on the original experimental data. We illustrate GenePath's approach and utility on analysis of data on aggregation and sporulation of the soil amoeba Dictyostelium discoideum.
authors.affiliation: Faculty of Computer and Information Science, University of Ljubljana, Trzaska 25, SI-1000 Ljubljana, Slovenia. blaz.zupan@fri.uni-lj.si
authors.forename: Blaz
authors.initials: B
authors.lastname: Zupan
authors.forename: Ivan
authors.initials: I
authors.lastname: Bratko
authors.forename: Janez
authors.initials: J
authors.lastname: Demsar
authors.forename: Peter
authors.initials: P
authors.lastname: Juvan
authors.forename: Tomaz
authors.initials: T
authors.lastname: Curk
authors.forename: Urban
authors.initials: U
authors.lastname: Borstnik
authors.forename: J Robert
authors.initials: JR
authors.lastname: Beck
authors.forename: John
authors.initials: J
authors.lastname: Halter
authors.forename: Adam
authors.initials: A
authors.lastname: Kuspa
authors.forename: Gad
authors.initials: G
authors.lastname: Shaulsky
mesh_terms: D000818:Animals; D004247:DNA; D004023:Dictyostelium / Q000235:genetics; D005786:Gene Expression Regulation; D023281:Genomics; D006801:Humans; D019359:Knowledge; D016571:Neural Networks, Computer; D012106:Research / Q000639:trends
chemical_list: D004247:DNA