title: [As-needed treatment with gastric acid inhibitors in gastroesophageal reflux disease].
abstract: Although proton pump inhibitors and H2-receptor antagonists are usually prescribed for continuous use by patients with gastro-oesophageal reflux disease, at least 50% of such patients do not take their medication daily and some take it only sporadically. On-demand treatment with proton pump inhibitors or H2-receptor antagonists is safe and cost-effective. Indications are: (a) incidental reflux episodes of short duration, (b) periodic reflux lasting several weeks or months, (c) chronic reflux not requiring continuous treatment. On-demand treatment is unsuitable for patients with reflux disease who either require daily medication or in whom the maximal dosage is insufficient. There are three types of on-demand treatment. Type 1: use of medication only in case of incidental symptoms. Type 2: continuous medication for 2-4 weeks when symptoms appear. Type 3: continuous use because of chronic symptoms, but the interval between doses is determined by the patient on the basis of his symptoms. All antacids can in principle be used for on-demand treatment; for type 3 treatment, antacids with a rapid onset of action are preferred. A favourable response to the two weeks of initial therapy is a good predictor for successful on-demand treatment.
authors.affiliation: Meander Medisch Centrum, afd. Interne Geneeskunde en Gastroenterologie, Amersfoort. poen@wanadoo.nl
authors.forename: A C
authors.initials: AC
authors.lastname: Poen
authors.forename: M H
authors.initials: MH
authors.lastname: Otten
mesh_terms: D000863:Antacids / Q000008:administration & dosage / Q000191:economics / Q000627:therapeutic use*; D003362:Cost-Benefit Analysis; D005744:Gastric Acid / Q000378:metabolism; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000191:economics / Q000627:therapeutic use*; D006801:Humans; D054328:Proton Pump Inhibitors; D012449:Safety
chemical_list: D000863:Antacids; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors
vernacular_title: 'Zo nodig'-gebruik van zuurremmende middelen bij refluxziekte.