Membrane-associated CD40L and sCD40L in atherothrombotic disease.
Recent data suggests that CD40L is involved in the pathogenesis of atherothrombotic disease. This review will focus on the history of CD40L, its role in platelet-mediated pathogenesis of atherothrombotic disease, its association to clinical syndromes and procedures, and its role in determining plaque rupture.
Anand
Sunil X
SX
The Zena and Michael A. Weiner Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York. USA.
Viles-Gonzalez
Juan F
JF
Badimon
Juan J
JJ
Cavusoglu
Erdal
E
Marmur
Jonathan D
JD
D001157:Arterial Occlusive Diseases / Q000097:blood / Q000209:etiology* / Q000473:pathology; D023201:CD40 Ligand / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction; D012995:Solubility; D013927:Thrombosis / Q000097:blood / Q000209:etiology* / Q000473:pathology
D010980:Platelet Membrane Glycoproteins; D023201:CD40 Ligand; D020782:Matrix Metalloproteinases