No association of germline alteration of MSR1 with prostate cancer risk.
The macrophage scavenger receptor 1 gene (MSR1) was recently identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer. To confirm these findings, we screened MSR1 for germline mutations among individuals with familial prostate cancer and tested gene variants for associations in both sporadic and familial prostate cancer. Our results do not support MSR1 as a risk factor for prostate cancer.
Wang
Liang
L
Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, 920 Hilton Building, Mayo Clinic and Foundation, Rochester, Minnesota, USA.
McDonnell
Shannon K
SK
Cunningham
Julie M
JM
Hebbring
Scott
S
Jacobsen
Steven J
SJ
Cerhan
James R
JR
Slager
Susan L
SL
Blute
Michael L
ML
Schaid
Daniel J
DJ
Thibodeau
Stephen N
SN
D000368:Aged; D000369:Aged, 80 and over; D014644:Genetic Variation; D018095:Germ-Line Mutation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000453:epidemiology / Q000235:genetics*; D011971:Receptors, Immunologic / Q000235:genetics*; D051116:Receptors, Scavenger; D012016:Reference Values; D012307:Risk Factors; D051117:Scavenger Receptors, Class A
C495139:MSR1 protein, human; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D051117:Scavenger Receptors, Class A; D017430:Prostate-Specific Antigen