(Z)-1-Aryl-1-haloalkenes as intermediates in the Vilsmeier haloformylation of aryl ketones.
[reaction: see text] Vilsmeier reagents give (Z)-1-aryl-1-haloalkenes from aryl ketones bearing an electron-donating substituent at the ortho- or para-position. These haloalkenes are intermediates in the Vilsmeier haloformylation of the aryl ketones. Another reaction mechanistic pathway is thus available in certain Vilsmeier haloformylations, in competition with the commonly accepted route by way of an enaminoketone.
Lilienkampf
Annamaria
A
Department of Chemistry, Laboratory of Organic Chemistry and Laboratory for Instruction in Swedish, University of Helsinki, P.O. Box 55, FIN-00014, Finland.
Johansson
Mikael P
MP
Wähälä
Kristiina
K