title: [Occurrence of an organochlorine synergist S-421 in fish and shellfish].
abstract: S-421 is a synergist for pyrethroid and organophosphorus pesticides, and is widely used in termiticides or commercial household insecticides. S-421 is mutagenic, stable and ubiquitous in the environment, and has been detected in household dust, surface water, sediments and rain-water. Here we describe the concentration of S-421 residues in domestic and imported fish collected in Osaka. S-421 was extracted with acetone/hexane, purified through silica gel 40 and quantified by ECD-GC. S-421 was detected in 36 out of 44 samples of domestic fish and shellfish analyzed, at a level of < 0.2 to 2.3 ng/g (mean: 0.6 ng/g), and in 27 out of 43 imported samples at a level of < 0.2 to 1.0 ng/g (mean: 0.2 ng/g). The levels of S-421 detected in fish were lower than those of DDTs and almost the same as those of HCHs. More attention should be paid to the behavior in the environment of S-421, as well as other persistent organochlorine pollutants, such as HCHs, DDTs and chlordane.
authors.affiliation: Osaka Prefectural Institute of Public Health: 1-3-69, Nakamichi, Higashinari-ku, Osaka 537-0025, Japan.
authors.forename: Seisaku
authors.initials: S
authors.lastname: Yoshida
authors.forename: Shuzo
authors.initials: S
authors.lastname: Taguchi
authors.forename: Yukio
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Shinjiro
authors.initials: S
authors.lastname: Hori
mesh_terms: D000818:Animals; D004357:Drug Synergism; D004987:Ethers / Q000032:analysis* / Q000494:pharmacology; D005399:Fishes / Q000378:metabolism*; D007306:Insecticides / Q000494:pharmacology*; D007564:Japan; D009153:Mutagens / Q000032:analysis*; D010573:Pesticide Residues / Q000032:analysis*; D012758:Shellfish / Q000032:analysis*
chemical_list: D004987:Ethers; D007306:Insecticides; D009153:Mutagens; D010573:Pesticide Residues; C017970:bis(2,3,3,3-tetrachloropropyl) ether