Successful intracytoplasmic sperm injection after failed in vitro fertilization due to multipronuclear oocytes.
OBJECTIVE
To report a case of IVF with apparently normal female and male gametes that resulted in the development of only multipronuclear oocytes (instead of oocytes containing two pronuclei) and was successfully treated with ICSI.


METHODS
Case report.


METHODS
A university hospital.


METHODS
A 35-year-old woman with unexplained infertility and her partner, a 38-year-old man with normozoospermia.


METHODS
Intracytoplasmic sperm injection.


METHODS
Oocyte fertilization and pregnancy.


RESULTS
Normal fertilization and an ongoing pregnancy occurred after transfer of two embryos.


CONCLUSIONS
Although the usual indication for ICSI is male subfertility, it can also be used to successfully treat oocyte defects.
van der Westerlaken
Lucette
L
Department of Reproductive Medicine, Leiden University Medical Centre, Leiden, The Netherlands. l.a.j.van_der_westerlaken@lumc.nl
Helmerhorst
Frans
F
Verburg
Harjo
H
Naaktgeboren
Nico
N
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D008297:Male; D009865:Oocytes / Q000648:ultrastructure*; D011247:Pregnancy; D019233:Retreatment; D020554:Sperm Injections, Intracytoplasmic; D017211:Treatment Failure