Eicosanoids: lipid mediators of inflammation in transplantation.
Eicosanoids are a family of lipid mediators derived from the metabolism of arachidonic acid. Eicosanoids, such as prostanoids and leukotrienes, have a wide range of biological actions including potent effects on inflammation and immunity. It has been almost 20 years since the first reports emerged suggesting a role for eicosanoids in transplantation. Since then, a number of functions have been ascribed to these mediators, ranging from immunomodulation to regulation of allograft hemodynamics. In this review, we will highlight the effects of eicosanoids in transplantation, focusing particularly on evidence provided by gene targeting studies. In the future, pharmacological manipulation of eicosanoids and their receptors may provide a novel approach for controlling inflammation and promoting allograft acceptance.
Rocha
Paulo N
PN
Department of Medicine, Division of Nephrology, Duke University and Durham VA Medical Centers, Building 6/Nephrology, 508 Fulton Street, Durham, NC 27705, USA.
Plumb
Troy J
TJ
Coffman
Thomas M
TM
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D051546:Cyclooxygenase 2; D015777:Eicosanoids / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000503:physiopathology*; D018836:Inflammation Mediators / Q000737:chemistry / Q000502:physiology*; D007527:Isoenzymes / Q000378:metabolism; D008565:Membrane Proteins; D016377:Organ Transplantation; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015777:Eicosanoids; D018836:Inflammation Mediators; D007527:Isoenzymes; D008565:Membrane Proteins; D001094:Arachidonate 5-Lipoxygenase; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases