title: Diagnostic value of cytology and colposcopy for squamous and glandular cervical intraepithelial lesions.
abstract: The main objective of work was to determine a diagnostic value of cytology and colposcopy as a method of screening and differential diagnosis, as well as to determine the relative value of some colposcopic features of squamous and glandular cervical intraepithelial lesions. Cytological diagnosis and colposcopy findings is compared with histological ones for 187 patients with intraepithelial lesions (142 squamous and 45 glandular ones with or without squamous components) and determined the sensitivity and positive predictive value of cytology and colposcopy, including the types of colposcopic abnormalities associated with squamous/glandular intraepithelial lesions. The sensitivity of cytology as a screening method for SIL (squamous intraepithelial lesions) is 89% and for GIL (glandular intraepithelial lesions) 98%. Positive predictive value of differential cytology for SIL is 59% and for GIL 53%. Sensitivity of colposcopy for both lesions' type is 87%. Acetowhite epithelium occurs for more often with SIL, whereas atypical vessels and unequal, dilated gland openings with GIL (p < 0.05). Cytology and colposcopy as screening methods have a high sensitivity. Nevertheless, cytology is far more accurate in determining differential diagnosis of SIL than GIL and some colposcopy abnormalities suspicious of GIL should be further tested in praxis.
authors.affiliation: Department of Clinical Cytology, University Hospital, Osijek, Osijek, Croatia.
authors.forename: Marija
authors.initials: M
authors.lastname: Pajtler
authors.forename: Silvana
authors.initials: S
authors.lastname: Audy-Jurković
authors.forename: Ana
authors.initials: A
authors.lastname: Ovanin-Rakić
authors.forename: Zvonimir
authors.initials: Z
authors.lastname: Makarović
authors.forename: Miodrag
authors.initials: M
authors.lastname: Milojković
authors.forename: Nikola
authors.initials: N
authors.lastname: Ljubojević
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology*; D003585:Cell Biology / Q000592:standards; D003127:Colposcopy; D003937:Diagnosis, Differential; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008403:Mass Screening; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000473:pathology*