The antiphospholipid syndrome and atherosclerosis: clue to pathogenesis.
Regulation of blood vessels is intrinsically tied to inflammatory signaling. Recent research suggests that chronic inflammation is associated with atherosclerosis risk. The antiphospholipid syndrome is a prototypic autoimmune disease. Disturbance of blood vessel homeostasis in this disorder may increase risk for atherosclerosis by mechanisms that are direct (through antibody targeting of blood vessel-regulating proteins) or indirect (via inflammatory mechanisms that have recently been implicated in autoantibody-mediated thrombosis).
Merrill
Joan T
JT
Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, 825 Northeast 13th Street, Oklahoma City, OK 73104, USA. joan-merrill@omrf.ouhsc.edu
D016736:Antiphospholipid Syndrome / Q000276:immunology* / Q000503:physiopathology; D001161:Arteriosclerosis / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D001323:Autoantibodies / Q000276:immunology; D001808:Blood Vessels / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007249:Inflammation
D001323:Autoantibodies