title: Nasal obstruction in sleep-disordered breathing.
abstract: It has been 30 years since Cottle suggested that "sleeping patterns are in great measure dependent on good nasal function" [1]. During this time, we have identified the OSAHS and related forms of sleep-disordered breathing such as UARS, and better appreciate the clinical sequelae of recurrent arousals and sleep fragmentation. Yet the exact role that obstructed nasal breathing plays in the pathogenesis of such sleep disorders remains presumptive, and robust clinical studies to corroborate this theory remain elusive; however, patients who may benefit most from correction of nasal obstruction as a sole intervention may be those with the mildest forms of sleep-disordered breathing without other significant predisposing anatomic abnormalities. Clearly, more stringently controlled studies [17,105] are needed, particularly in these types of patients. Until such time, it is reasonable to address issues of nasal obstruction as an adjunct to surgical and nonsurgical treatment in all patients who are diagnosed with a sleep-related breathing disorder.
authors.affiliation: Stanford University Center of Excellence for Sleep Disorders, 401 Quarry Road, Suite 3301, Stanford, CA 94305, USA.
authors.forename: Wynne
authors.initials: W
authors.lastname: Chen
authors.forename: Clete A
authors.initials: CA
authors.lastname: Kushida
mesh_terms: D002648:Child; D006801:Humans; D006984:Hypertrophy / Q000150:complications / Q000473:pathology / Q000601:surgery; D007223:Infant; D014663:Nasal Decongestants / Q000627:therapeutic use; D015508:Nasal Obstruction / Q000150:complications* / Q000209:etiology / Q000601:surgery; D014066:Palatine Tonsil / Q000473:pathology / Q000601:surgery; D012221:Rhinitis, Allergic, Perennial / Q000150:complications / Q000188:drug therapy; D012891:Sleep Apnea Syndromes / Q000209:etiology*
chemical_list: D014663:Nasal Decongestants