title: [Expression of aquaporin - 4 protein in brain from rats with hemorrhagic edema].
abstract: OBJECTIVE
  To study the expression of aquaporin-4 (AQP4) protein in perihematomal tissue after intracerebral hemorrhage (ICH) in rats.
  
  
  METHODS
  The experimental ICH model was established in rats by injecting quantitative collagenase into the left caudate nuclei of the rats. The changes of brain water content (BWC) were measured by the wet and dry weight methods. Immunohistochemistry was used to determine the change of expression of AQP4 protein during different periods after ICH.
  
  
  RESULTS
  BWC and AQP4 protein expression in perihematomal tissue were increased at 6 hours after ICH and reached peak at 72 hours. In one week following ICH, it was still higher than normal level. In addition, the expression of AQP4 was positively correlated with BWC (r=0.9857, P<0.01).
  
  
  CONCLUSIONS
  AQP4 has a relevant relationship with the formation of brain edema after ICH.
authors.affiliation: Department of Neurobiology, Chongqing University of Medical Science, Chongqing 400016, China.
authors.forename: Yan-hua
authors.initials: YH
authors.lastname: Li
authors.forename: Shan-quan
authors.initials: SQ
authors.lastname: Sun
mesh_terms: D000818:Animals; D051401:Aquaporin 4; D020346:Aquaporins / Q000032:analysis*; D001921:Brain / Q000378:metabolism*; D001929:Brain Edema / Q000378:metabolism* / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: C496032:Aqp4 protein, rat; D051401:Aquaporin 4; D020346:Aquaporins