Alkylation of manganese(II) tetraphenylporphyrin by a synthetic antimalarial trioxane.
The synthesis and the antimalarial activity of a new kind of polycyclic 1,2,4-trioxanes are reported. The alkylation of the heme model MnIITPP by the biologically active (IC 50 = 320 nmol L-1) hemiperketal 2 is presented.
Berrien
Jean-François
JF
UMR 8076 BioCIS, Faculté de Pharmacie, rue J.-B. Clément, F-92296 Châtenay-Malabry, France.
Provot
Olivier
O
Mayrargue
Joëlle
J
Coquillay
Michel
M
Cicéron
Liliane
L
Gay
Frédérick
F
Danis
Martin
M
Robert
Anne
A
Meunier
Bernard
B
D000478:Alkylation; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D018360:Crystallography, X-Ray; D006418:Heme / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008665:Metalloporphyrins / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects / Q000235:genetics
D000962:Antimalarials; D006571:Heterocyclic Compounds; D008665:Metalloporphyrins; C478042:manganese(II) tetraphenylporphyrin; D006418:Heme; D002738:Chloroquine