Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?
Intra-myocellular triglycerides (IMTG) accumulate in the muscle of obese and endurance-trained (ET) humans and are considered a pathogenic factor in the development of insulin resistance, in the former. We postulate that this paradox may be associated with the peroxidation status of the IMTG. IMTG content was the same in the obese and ET subjects. The lipid peroxidation/IMTG ratio was 4.2-fold higher in the obese subjects. Hence, obesity results in an increased level of IMTG peroxidation while ET has a protective effect on IMTG peroxidation. This suggests a link between the lipid peroxidation/IMTG ratio and insulin resistance.
Russell
Aaron P
AP
Clinique Romande de Réadaptation SUVA Care, Case postale 352, 1951 Sion, Switzerland. aaron.russell@crr-suva.ch
Gastaldi
Giacomo
G
Bobbioni-Harsch
Elisabetta
E
Arboit
Patrizia
P
Gobelet
Charles
C
Dériaz
Olivier
O
Golay
Alain
A
Witztum
Joseph L
JL
Giacobino
Jean-Paul
JP
D000328:Adult; D000447:Aldehydes / Q000032:analysis; D006801:Humans; D015227:Lipid Peroxidation; D008055:Lipids / Q000145:classification; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000737:chemistry / Q000166:cytology / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D010807:Physical Endurance; D014280:Triglycerides / Q000032:analysis / Q000378:metabolism*
D000447:Aldehydes; D008055:Lipids; D014280:Triglycerides; C027576:4-hydroxy-2-nonenal