title: Beryllium chemical speciation in elemental human biological fluids.
abstract: The understanding of beryllium chemistry in human body fluids is important for understanding the prevention and treatment of chronic beryllium disease. Thermodynamic modeling has traditionally been used to study environmental contaminant migration and rarely in the examination of metal (particularly beryllium) toxicology. In this work, a chemical thermodynamic speciation code (MINTEQA2) has been used to model and understand the chemistry of beryllium in simulated human biological fluids such as intracellular, interstitial, and plasma fluids, a number of airway surface fluids for patients with lung conditions, saliva, sweat, urine, bile, gastric juice, and pancreatic fluid. The results show that predicted beryllium solubility and speciation vary markedly between each simulated biological fluid. Formation of beryllium hydroxide and/or phosphate was observed in most of the modeled fluids, and results support the postulation that beryllium absorption in the gastrointestinal tract may be limited by the formation of beryllium phosphate solids. It is also postulated that beryllium is potentially 13% less soluble in the airway surface fluid of a patient with asthma when compared to a "normal" case. The results of this work, supported by experimental validation, can aid in the understanding of beryllium toxicology. Our results can potentially be applied to assessing the feasibility of biological monitoring or chelation treatment of beryllium body burden.
authors.affiliation: Analytical and Nuclear Chemistry Division, Lawrence Livermore National Laboratory, P.O. Box 808, Livermore, California 94551, USA. Sutton18@llnl.gov
authors.forename: Mark
authors.initials: M
authors.lastname: Sutton
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Burastero
mesh_terms: D001607:Berylliosis / Q000503:physiopathology; D001608:Beryllium / Q000009:adverse effects / Q000737:chemistry* / Q000378:metabolism*; D001822:Body Burden; D001826:Body Fluids / Q000737:chemistry* / Q000378:metabolism* / Q000502:physiology; D002254:Carbonates / Q000737:chemistry / Q000378:metabolism; D002712:Chlorides / Q000737:chemistry / Q000378:metabolism; D004781:Environmental Exposure; D005459:Fluorides / Q000737:chemistry / Q000378:metabolism; D005544:Forecasting; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D006878:Hydroxides / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D010710:Phosphates / Q000737:chemistry / Q000378:metabolism; D012137:Respiratory System / Q000187:drug effects; D012463:Saliva / Q000737:chemistry / Q000378:metabolism; D012995:Solubility; D013542:Sweat / Q000737:chemistry / Q000378:metabolism
chemical_list: D002254:Carbonates; D002712:Chlorides; D006878:Hydroxides; D010710:Phosphates; D001608:Beryllium; D005459:Fluorides