title: Possible association between -G308A tumour necrosis factor-alpha gene polymorphism and major depressive disorder in the Korean population.
abstract: OBJECTIVE
  The present study was aimed at examining the association between the -G308A tumour necrosis factor-alpha gene polymorphism and major depressive disorder (MDD) in the Korean population.
  
  
  METHODS
  One hundred and eight in-patients with MDD and 125 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism.
  
  
  RESULTS
  Genotype and allele distributions in patients with MDD (P=0.024 and P=0.0125, respectively), were significantly different from those of the controls. In particular, subjects with MDD had an increased frequency of the TNF2 (A) allele.
  
  
  CONCLUSIONS
  The present study suggests that the -G308A tumour necrosis factor-alpha gene polymorphism may have a potential role for susceptibility to MDD in the Korean population.
authors.affiliation: Department of Psychiatry, Kangnam St Mary's Hospital, The Catholic University of Korea College of Medicine, 505 Banpo-Dong, Seocho-Gu, Seoul 137-401, Korea.
authors.forename: Tae-Youn
authors.initials: TY
authors.lastname: Jun
authors.forename: Chi-Un
authors.initials: CU
authors.lastname: Pae
authors.lastname: Hoon-Han
authors.forename: Jeong-Ho
authors.initials: JH
authors.lastname: Chae
authors.forename: Won-Myong
authors.initials: WM
authors.lastname: Bahk
authors.forename: Kwang-Soo
authors.initials: KS
authors.lastname: Kim
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
mesh_terms: D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D017931:DNA Primers; D003866:Depressive Disorder / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012016:Reference Values; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D017931:DNA Primers; D014409:Tumor Necrosis Factor-alpha