[Melanoma antigen genes(MAGE) and malignant tumors].
The melanoma antigen genes(MAGE) were found to express in a variety of tumors of different histological origin. Peptides encoded by the MAGE genes are tumor rejection antigens, which can induce specific cytotoxic T-lymphocytes(CTL) to recognize and kill tumor cells. This lead to the idea of using MAGE genes as the targets for cancer immunotherapy. This article reviews the discovery, development, role, and therapeutic potential of MAGE tumor-associated antigens.
Xu
Jian-Zhong
JZ
Department of Otorhinolaryngology, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou, Zhejiang, 310006, PR China.
Lin
Shan
S
D000951:Antigens, Neoplasm / Q000235:genetics*; D005805:Genes, MHC Class I; D006801:Humans; D008545:Melanoma / Q000276:immunology*; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000235:genetics; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000951:Antigens, Neoplasm; C072013:MAGEA3 protein, human; C110905:MAGEC1 protein, human; C120897:MAGED1 protein, human; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins