Open pilot study of gabapentin versus trazodone to treat insomnia in alcoholic outpatients.
Alcohol-dependent outpatients with persisting insomnia were treated with either gabapentin or trazodone. Patients were assessed at baseline and after 4-6 weeks on medication using the Sleep Problems Questionnaire (SPQ). Of 55 cases initially treated, 9% dropped out due to morning drowsiness. Of the remaining 50 cases, 34 were treated with gabapentin (mean dose +/- SD = 888 +/- 418 mg) at bedtime and 16 were treated with trazodone (105 +/- 57 mg) at bedtime. Both groups improved significantly on the SPQ but the gabapentin group improved significantly more than the trazodone group. Controlled studies are warranted to replicate these findings.
Karam-Hage
Maher
M
Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan 48108, USA.
Brower
Kirk J
KJ
D000085:Acetates / Q000627:therapeutic use*; D000437:Alcoholism / Q000150:complications*; D000588:Amines; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D003509:Cyclohexanecarboxylic Acids; D005260:Female; D000077206:Gabapentin; D006801:Humans; D008297:Male; D010045:Outpatients; D010865:Pilot Projects; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy* / Q000209:etiology*; D012894:Sleep Stages / Q000187:drug effects; D014196:Trazodone / Q000627:therapeutic use*; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D018687:Antidepressive Agents, Second-Generation; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D014196:Trazodone