[Inhibition effect of merthiolate used as vaccines preservative on the oxygen-dependent metabolism of neutrophil granulocytes].
The influence of the newly developed complex vaccine Pyopol, containing the antigens of opportunistic microorganisms and polyoxydonium used as immunomodulator, on the oxygen-dependent metabolism of neutrophils was studied. The study revealed that the main components of the vaccine, both individually and in association, did not change cellular activity in the range of concentrations used in this study. The inhibition of the oxygen-dependent metabolism of neutrophil granulocytes in the presence of native or weakly diluted vaccine occurred due to the cytotoxic effect of thimerosal used as preservative.
Zinkin
V Iu
VIu
Sklifosovsky Research Institute of Emergency Aid, Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
Mikhaĭlova
N A
NA
Khvatov
V B
VB
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000942:Antigens, Bacterial / Q000494:pharmacology; D001428:Bacterial Vaccines / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D009930:Organic Chemicals; D011310:Preservatives, Pharmaceutical / Q000494:pharmacology*; D011511:Proteus / Q000276:immunology; D016897:Respiratory Burst; D013210:Staphylococcus / Q000276:immunology; D013849:Thimerosal / Q000494:pharmacology*; D014121:Toxoids / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D009930:Organic Chemicals; D011310:Preservatives, Pharmaceutical; D014121:Toxoids; C089921:polyoxydonium; D013849:Thimerosal
Effekt podavleniia kislorodzavisimogo matabolizma neĭtrofil'nykh granulotsitov mertiolatom, ispol'zuemym v kachestve konservanta vaktsin.