title: Gene silencing of the p15/INK4B cell-cycle inhibitor by hypermethylation: an early or later epigenetic alteration in myelodysplastic syndromes?
authors.affiliation: Department Internal Medicine I, Division of Hematology/Oncology, University of Freiburg Medical Center, Freiburg, Germany. luebbert@mm11.ukl.uni-freiburg.de
authors.forename: M
authors.initials: M
authors.lastname: Lübbert
mesh_terms: D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000235:genetics*; D018899:CpG Islands; D050762:Cyclin-Dependent Kinase Inhibitor p15; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics*; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000378:metabolism; D019175:DNA Methylation; D004791:Enzyme Inhibitors; D020868:Gene Silencing; D016147:Genes, Tumor Suppressor; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D025521:Tumor Suppressor Proteins
chemical_list: C493966:CDKN2B protein, human; D018797:Cell Cycle Proteins; D050762:Cyclin-Dependent Kinase Inhibitor p15; D019941:Cyclin-Dependent Kinase Inhibitor p16; D004791:Enzyme Inhibitors; D025521:Tumor Suppressor Proteins; D004248:DNA (Cytosine-5-)-Methyltransferases