Kinesin motors and microtubule-based organelle transport in Dictyostelium discoideum.
Movement of membrane cargoes and chromosomes is driven by kinesin and dynein motors in most eukaryotic cells. In this review, we describe the known kinesin and dynein genes in Dictyostelium. Dictyostelium primarily utilizes two conventional kinesins, an Unc104/KIF1 kinesin, and cytoplasmic dynein to transport membrane organelles within its cytoplasm. We describe how the biological functions of these motors has been dissected through a combination of biochemical to genetic approaches.
Klopfenstein
Dieter R
DR
Department of Cellular and Molecular Pharmacology, University of California San Francisco, 600 16th Street, San Francisco, CA 94107, USA.
Holleran
Elizabeth A
EA
Vale
Ronald D
RD
D000595:Amino Acid Sequence; D000818:Animals; D004023:Dictyostelium / Q000235:genetics / Q000502:physiology*; D016547:Kinesins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D009068:Movement / Q000502:physiology; D015388:Organelles / Q000502:physiology*; D015800:Protozoan Proteins / Q000502:physiology*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D015800:Protozoan Proteins; D016547:Kinesins