title: Presence of human immunodeficiency virus-1-specific CD4 and CD8 cellular immune responses in children with full or partial virus suppression.
abstract: The present study assessed antiviral T cell immune responses in 48 human immunodeficiency virus (HIV)-infected children with a stable or decreasing CD4(+) T cell counts and different levels of viral control, in the presence or absence of antiretroviral therapy. Children with full (<40 copies/mL) or partial (<50,000 copies/mL) virus suppression and with a history of stable CD4(+) T cell counts had significantly increased levels of anti-HIV CD4(+) T cell lymphoproliferative responses, lower levels of CD38(+), and higher CD8(+)/CD28(+) T cell percentage, compared with those in treated children with a lack of virus suppression (>50,000 copies/mL). Levels of anti-HIV CD8(+) T cell activity, although higher in treated children with a lack of virus suppression, were not significantly different between the groups. Although levels of anti-HIV CD4(+) and CD8(+) T cell responses were not associated, these levels of responses were associated with the percentage of specific T cell subsets. Overall, a history of stable CD4(+) T cell counts, as a result of therapy that imparted full or partial virus suppression, was associated with increased levels of anti-HIV CD4(+) T helper responses and decreased T cell activation.
authors.affiliation: The Wistar Institute, Philadelphia, USA.
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Papasavvas
authors.forename: Johan K
authors.initials: JK
authors.lastname: Sandberg
authors.forename: Richard
authors.initials: R
authors.lastname: Rutstein
authors.forename: Elizabeth C
authors.initials: EC
authors.lastname: Moore
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Mackiewicz
authors.forename: Brian
authors.initials: B
authors.lastname: Thiel
authors.forename: Maxwell
authors.initials: M
authors.lastname: Pistilli
authors.forename: Rayford R
authors.initials: RR
authors.lastname: June
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Jordan
authors.forename: Robert
authors.initials: R
authors.lastname: Gross
authors.forename: Vernon C
authors.initials: VC
authors.lastname: Maino
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Nixon
authors.forename: Luis J
authors.initials: LJ
authors.lastname: Montaner
mesh_terms: D000293:Adolescent; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002648:Child; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D016130:Immunophenotyping; D008213:Lymphocyte Activation; D012367:RNA, Viral / Q000097:blood; D019562:Viral Load
chemical_list: D012367:RNA, Viral