Synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, an analogue of 15R-lipoxin A4.
We describe a method for the synthesis of methyl (5S,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate, a compound that has been described as a metabolically stable analogue of 15R-lipoxin A(4).
Phillips
Eifion D
ED
Department of Chemistry, AstraZeneca R&D Wilmington, 1800 Concord Pike, Wilmington, DE 19850, USA. eifion.phillips@astrazeneca.com
Chang
Hui-Fang
HF
Holmquist
Christopher R
CR
McCauley
John P
JP
D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis*; D044045:Lipoxins / Q000138:chemical synthesis*
D005231:Fatty Acids, Unsaturated; D044045:Lipoxins; C114465:hexadecatetraenoic acid; C040527:lipoxin A4