title: [Accuracy of the CT-estimated weight of the right hepatic lobe prior to living related liver donation (LRLD) for predicting the intraoperatively measured weight of the graft].
abstract: OBJECTIVE
  Due to the shortage of cadaver donors, living related liver donation (LRLD) has emerged as an alternative to cadaver donation. The expected graft weight is one of the main determinants for donor selection. This study investigates the accuracy of preoperatively performed CT-volumetry to predict the actual weight of the right liver lobe graft.
  
  
  METHODS
  In a prospective study the weight of the right hepatic lobe was calculated by volumetric analysis based on CT in 33 patients (21 females, 12 males, mean age 42.1 years, median age 41 years) prior to living related liver donation. Graft weight was calculated as the product of CT-based graft volume and 1.00 g/ml (the approximated density of healthy liver parenchyma). The calculated weight was compared with the intraoperatively measured weight of the harvested right hepatic lobe. The difference was used to determine a correction factor for estimating the actual graft weight.
  
  
  RESULTS
  Based on the assumption of a parenchymal density of 1.00 g/ml, the preoperatively estimated graft weight (mean 980 g +/- 168 g) deviated +33 % from the intraoperatively measured right hepatic lobe weight (mean 749 g +/- 170 g). By reducing the preoperatively predicted weight of the right hepatic lobe with a correction factor of 0.75, the actual graft weight can be calculated.
  
  
  CONCLUSIONS
  Preoperative estimation of the weight of the right hepatic lobe based on CT of living related liver donors predicts the weight of the right lobe graft with sufficient accuracy by applying a single correction factor. Intraoperative fluid loss (i.e., blood, bile) from the harvested liver as well as variations in parenchymal density may contribute to the observed preoperative overestimation of the actual graft volume by CT-based volumetry.
authors.affiliation: Universitätsklinikum Charité, Campus Virchow-Klinikum, Klinik für Strahlenheilkunde, Berlin. lemke@charite.de
authors.forename: A-J
authors.initials: AJ
authors.lastname: Lemke
authors.forename: M J
authors.initials: MJ
authors.lastname: Brinkmann
authors.forename: A
authors.initials: A
authors.lastname: Pascher
authors.forename: T
authors.initials: T
authors.lastname: Steinmüller
authors.forename: U
authors.initials: U
authors.lastname: Settmacher
authors.forename: P
authors.initials: P
authors.lastname: Neuhaus
authors.forename: R
authors.initials: R
authors.lastname: Felix
mesh_terms: D000328:Adult; D000368:Aged; D002102:Cadaver; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging*; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011446:Prospective Studies; D020858:Tissue and Organ Harvesting; D014057:Tomography, X-Ray Computed
vernacular_title: Voraussagegenauigkeit der präoperativen CT-gestützten Gewichtsbestimmung des rechten Leberlappens bezüglich des intraoperativen Transplantatgewichts bei Leberlappen-Lebendspendern.