title: Mantle cell lymphoma of the hard palate: a case report and review of the differential diagnosis based on the histomorphology and immunophenotyping pattern.
abstract: To our knowledge, mantle cell lymphoma (MCL) has never been reported in the hard palate, but it is commonly observed in the nasopharynx and Waldeyer's tonsillar ring. MCL is characterized by a diffuse infiltrate of small lymphocytes with the expression of CD5, CD20, and cyclin D1 (Bcl-1), but not CD10. MCL presenting in the hard palate must be accurately distinguished from other forms of so-called small B-cell lymphomas-such as small lymphocytic lymphoma, follicular lymphoma, and extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue-because MCL possesses a worse prognosis. Awareness of MCL of the hard palate will prompt pathologists to perform adequate immunohistochemical analysis to aid in confirming the diagnosis.
authors.affiliation: Medical College of Wisconsin and Marquette University, Milwaukee, Wis., USA. jeffchang@pol.net
authors.forename: Chung-Che
authors.initials: CC
authors.lastname: Chang
authors.forename: J Jordi
authors.initials: JJ
authors.lastname: Rowe
authors.forename: Philip
authors.initials: P
authors.lastname: Hawkins
authors.forename: Ezedin M
authors.initials: EM
authors.lastname: Sadeghi
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D018951:Antigens, CD20 / Q000032:analysis; D019938:Cyclin D1 / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D051917:Leukosialin; D020522:Lymphoma, Mantle-Cell / Q000473:pathology*; D008875:Middle Aged; D010157:Palatal Neoplasms / Q000473:pathology*; D021362:Palate, Hard / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D012795:Sialoglycoproteins / Q000032:analysis
chemical_list: D015703:Antigens, CD; D018951:Antigens, CD20; D051917:Leukosialin; D019253:Proto-Oncogene Proteins c-bcl-2; C465014:SPN protein, human; D012795:Sialoglycoproteins; D019938:Cyclin D1