title: Synthesis of covalently bonded cellulose derivative chiral stationary phases with a bifunctional reagent of 3-(triethoxysilyl)propyl isocyanate.
abstract: A bifunctional reagent of 3-(triethoxysilyl)propyl isocyanate (TEPI) was initially adopted as a spacer reagent to prepare the bonded types of chiral stationary phases (CSPs) with cellulose derivatives. The silica-based CSPs were chemically prepared with non-regioselective and regioselective approaches and their chiral resolving capabilities were evaluated in terms of HPLC resolution of test enantiomers. It was observed that the chiral recognition capabilities of the non-regioselectively prepared CSPs were influenced by the amount of TEPI used. And also, the regioselectively prepared CSP generally showed a slightly higher resolution power than the non-regioselectively prepared CSP, while the non-regioselective procedures were highly advantageous to rapid preparation. In addition, chiral recognition of the prepared CSPs was affected by the properties of the used silica matrices.
authors.affiliation: National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116011, China.
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Chen
authors.forename: Yueqi
authors.initials: Y
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Qin
authors.forename: Liang
authors.initials: L
authors.lastname: Kong
authors.forename: Hanfa
authors.initials: H
authors.lastname: Zou
mesh_terms: D002482:Cellulose / Q000138:chemical synthesis*; D007202:Indicators and Reagents / Q000737:chemistry*; D017953:Isocyanates / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C450924:3-(triethoxysilyl)-propylisocyanate; D007202:Indicators and Reagents; D017953:Isocyanates; D012821:Silanes; D002482:Cellulose