title: Derivatives of 2-mercaptobenzenesulphonamide. VIII. Synthesis and some pharmacological properties of 1,3-dialkyl-2-(4-chloro-2-carboxyalkylthio-5-methylbenzenesulphonyl) guanidines.
abstract: Synthesis of 1,3-dialkyl-2-(4-chloro-2-carboxyalkylthio-5-methylbenzenesulphonyl)guanidines (IX-XVII) and their easily soluble in water sodium (Xa-XIVa, XVIIa) or 2,6-dimethylpiperidine salts (XIb, XVIIb) have been described. The results of preliminary pharmacological examinations such as acute toxicity and influence on circulatory system have been presented.
authors.affiliation: Department of Drug Technology, School of Medicine, 107 K. Marksa Str., 80-416 Gdańsk, Poland.
authors.forename: Z
authors.initials: Z
authors.lastname: Brzozowski
authors.forename: J
authors.initials: J
authors.lastname: Sławiński
authors.forename: M
authors.initials: M
authors.lastname: Filczewski
authors.forename: M
authors.initials: M
authors.lastname: Szymańska-Kosmala
authors.forename: J
authors.initials: J
authors.lastname: Miłobedzka
authors.forename: K
authors.initials: K
authors.lastname: Oledzka
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D006146:Guanidines / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D006339:Heart Rate / Q000187:drug effects; D007202:Indicators and Reagents; D007928:Lethal Dose 50; D051379:Mice; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000889:Anti-Arrhythmia Agents; D006146:Guanidines; D007202:Indicators and Reagents