Activation of the CRF 2 receptor modulates skeletal muscle mass under physiological and pathological conditions.
Two receptors activated by the corticotropin-releasing factor (CRF) family of peptides have been identified, the CRF 1 receptor (CRF1R) and the CRF 2 receptor (CRF2R). Of these, the CRF2R is expressed in skeletal muscle. To understand the role of the CRF2R in skeletal muscle, we utilized CRFR knockout mice and CRF2R-selective agonists to modulate nerve damage and corticosteroid- and disuse-induced skeletal muscle atrophy in mice. These analyses demonstrated that activation of the CRF2R decreased nerve damage and corticosteroid- and disuse-induced skeletal muscle mass and function loss. In addition, selective activation of the CRF2R increased nonatrophy skeletal muscle mass. Thus we describe for the first time a novel activity of the CRF2R, modulation of skeletal muscle mass.
Hinkle
Richard T
RT
Research Division, Procter & Gamble Pharmaceuticals, Health Care Research Center, 8700 Mason-Montgomery Road, Mason, OH 45040-9317, USA.
Donnelly
Elizabeth
E
Cody
David B
DB
Samuelsson
Steven
S
Lange
Jana S
JS
Bauer
Mary Beth
MB
Tarnopolsky
Mark
M
Sheldon
Russell J
RJ
Coste
Sarah C
SC
Tobar
Eric
E
Stenzel-Poore
Mary P
MP
Isfort
Robert J
RJ
D029845:Amphibian Proteins; D000818:Animals; D003714:Denervation; D003907:Dexamethasone; D005260:Female; D006614:Hindlimb; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology*; D009133:Muscular Atrophy / Q000139:chemically induced / Q000503:physiopathology; D020966:Muscular Disorders, Atrophic / Q000503:physiopathology; D009929:Organ Size / Q000502:physiology; D036361:Peptide Hormones; D010455:Peptides / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018019:Receptors, Corticotropin-Releasing Hormone / Q000819:agonists / Q000172:deficiency* / Q000502:physiology*; D012584:Sciatic Nerve / Q000601:surgery; D013314:Stress, Mechanical
D029845:Amphibian Proteins; C101531:CRF receptor type 2; D036361:Peptide Hormones; D010455:Peptides; D018019:Receptors, Corticotropin-Releasing Hormone; C025727:sauvagine; D003907:Dexamethasone