Solubilization of Fluasterone in cosolvent/cyclodextrin combinations.
The combined effect of cosolvent (methanol (MeOH), ethanol (EtOH), or n-propanol (n-PrOH)) and complexant hydroxypropyl-beta-cyclodextrin (HP beta CD) on the solubility of Fluasterone is evaluated and explained with a simple equation. The calculated constants in the equation not only quantitatively describe the dependence of drug solubility on cosolvent and ligand concentrations, but also explain the minima that are observed in the Fluasterone solubility versus cosolvent concentration curves at fixed HP beta CD concentrations.
He
Yan
Y
College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA. he@pharmacy.arizona.edu
Li
Ping
P
Yalkowsky
Samuel H
SH
D000433:1-Propanol / Q000737:chemistry; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D003505:Cyclodextrins / Q000737:chemistry*; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000737:chemistry*; D004339:Drug Compounding; D000431:Ethanol / Q000737:chemistry; D005079:Excipients / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry; D012995:Solubility; D012997:Solvents / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D005079:Excipients; D012997:Solvents; D047392:beta-Cyclodextrins; D014867:Water; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000431:Ethanol; D003687:Dehydroepiandrosterone; D000433:1-Propanol; C106219:5-androstene-16-fluoro-17-one; D000432:Methanol