title: Acute myeloblastic leukemia in a patient with primary antiphospholipid syndrome.
abstract: Antiphospholipid syndrome is characterized by venous and arterial thrombosis, recurrent pregnancy loss and the presence of the lupus anticoagulant, anticardiolipin antibodies or both. Antiphospholipid syndrome may occur as a primary disease or in patients with systemic lupus erythematosus or other autoimmune, infectious or neoplastic disorders. In this paper we report a 29-year-old Saudi female, a known case of antiphospholipid syndrome, presented with complaints of fever, breathlessness and generalized fatigue. Further investigations confirmed her as a case of myeloblastic leukemia (M1, French-American-British classification). Acute myeloblastic leukemia is not described to be associated with primary antiphospholipid syndrome in the literature to date. This is the first case report of such association.
authors.affiliation: Department of Medicine, Al Iman General Hospital, Ministry of Health, PO Box 346225, Riyadh 11381, Kingdom of Saudi Arabia. shivksaxena@yahoo.com
authors.forename: Shiv K
authors.initials: SK
authors.lastname: Saxena
authors.forename: Salih A
authors.initials: SA
authors.lastname: Bin Salih
authors.forename: Ahmed H
authors.initials: AH
authors.lastname: Al-Jizeeri
authors.forename: Osman A
authors.initials: OA
authors.lastname: Kheir
mesh_terms: D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications*; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology; D004417:Dyspnea / Q000175:diagnosis; D005221:Fatigue / Q000175:diagnosis; D005334:Fever / Q000175:diagnosis; D006801:Humans; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000276:immunology; D008297:Male; D012529:Saudi Arabia