FT-IR spectroscopic analysis of normal and cancerous tissues of esophagus.
OBJECTIVE
To investigate the special Fourier transform infrared spectroscopy (FT-IR) spectra in normal and cancerous tissues of esophagus.


METHODS
Twenty-seven pairs of normal and cancerous tissues of esophagus were studied by using FT-IR and the special spectra characteristics were analyzed in different tissues.


RESULTS
Different spectra were found in normal and cancerous tissues. The peak at 1 550/cm was weak and wide in cancerous tissues but strong and high in normal tissues. The ratio of I 1 647/I 1 550 was 2.0 in normal tissues and 2.36 in cancerous tissues (P<0.05). The ratio of I 1 550/I 1 080 was 4.5 in normal tissues and 3.4 in cancerous tissues (P<0.01). The peak at 1453 /cm was higher than at 1 402/cm in normal tissue and lower than at 1 402/cm in cancerous tissues.


CONCLUSIONS
The results indicate that FTIR may be used in clinical diagnosis.
Wang
Jian-Sheng
JS
Department of Oncological Surgery, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
Shi
Jing-Sen
JS
Xu
Yi-Zhuang
YZ
Duan
Xiao-Yi
XY
Zhang
Li
L
Wang
Jing
J
Yang
Li-Ming
LM
Weng
Shi-Fu
SF
Wu
Jin-Guang
JG
D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D004947:Esophagus / Q000378:metabolism*; D006801:Humans; D017550:Spectroscopy, Fourier Transform Infrared