title: Autoantibody-associated congenital heart block: the clinical perspective.
abstract: Congenital heart block (CHB) can occur in association with structural heart disease, such as atrioventricular septal defects, left atrial isomerism, and abnormalities of the great arteries, with tumors, such as mesotheliomas, or as an isolated defect. In 1928, Aylward reported the occurrence of CHB in two children whose mother "suffered from Mikulicz's disease." This curious clinical observation was further solidified by the 1970s, with reports of CHB in children whose mothers had autoimmune diseases and that the maternal sera contained antibodies to Ro ribonucleoproteins. It was subsequently reported that many mothers also had antibodies to La. Other abnormalities affecting the skin, liver, and blood elements were associated with anti-Ro/La antibodies in the maternal and fetal circulation, and are now grouped under the heading of neonatal lupus syndromes. Neonatal lupus was termed because the cutaneous lesions of the neonate resembled those seen in systemic lupus erythematosus.
authors.affiliation: Department of Rheumatology, Hospital for Joint Diseases, 301 East 17th Avenue, Room 1608, New York, NY 10003, USA. jill.buyon@med.nyu.edu
authors.forename: Jill P
authors.initials: JP
authors.lastname: Buyon
authors.forename: Deborah M
authors.initials: DM
authors.lastname: Friedman
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000151:congenital; D006327:Heart Block / Q000150:complications / Q000151:congenital* / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn
chemical_list: D001323:Autoantibodies