title: Serum alpha-fetoprotein screening for hepatoblastoma in children with Beckwith-Wiedemann syndrome or isolated hemihyperplasia.
abstract: An elevated risk of hepatoblastoma for children with Beckwith-Wiedemann syndrome or isolated hemihyperplasia is well established. We describe five children with Beckwith-Wiedemann syndrome or isolated hemihyperplasia for whom serial serum alpha-fetoprotein screening, usually in combination with abdominal ultrasound, led to early detection of hepatoblastoma.
authors.affiliation: Department of Pediatrics, University of New Mexico, ACC-3, Albuquerque, NM 87131, USA.
authors.forename: Carol L
authors.initials: CL
authors.lastname: Clericuzio
authors.forename: Emily
authors.initials: E
authors.lastname: Chen
authors.forename: Dawn Elizabeth
authors.initials: DE
authors.lastname: McNeil
authors.forename: Timothy
authors.initials: T
authors.lastname: O'Connor
authors.forename: Elaine H
authors.initials: EH
authors.lastname: Zackai
authors.forename: Livija
authors.initials: L
authors.lastname: Medne
authors.forename: Gail
authors.initials: G
authors.lastname: Tomlinson
authors.forename: Michael
authors.initials: M
authors.lastname: DeBaun
mesh_terms: D001506:Beckwith-Wiedemann Syndrome / Q000150:complications*; D005260:Female; D018197:Hepatoblastoma / Q000175:diagnosis*; D006801:Humans; D006984:Hypertrophy / Q000150:complications; D007223:Infant; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000175:diagnosis*; D008297:Male; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D000509:alpha-Fetoproteins