[Research on physiological function of CD47].
CD47, also known as integrin-associated protein (IAP), is an ubiquitously expressed 50 kD cell membrane glycoprotein. This article reviews that as an integrin-associated molecule, CD47 regulates a series of integrin-dependent cell functions; CD47 regulates cell adhesiveness, migration and activation and platelet aggregation through binding to thrombospondins; CD7 is the extracellular ligand for human signal-regulatory proteins, thus it causes negative regulatory effect; CD47 induces costimulatory signals on activation of T cell, T cell apoptosis and T cell anergy and enhances the efficiency of TCR signaling; CD47 is a member of Rh antigen complex. CD47 is involved in stroma-supported erythropoiesis. This review also discussed that CD47 as a marker on red blood cells, associated with haemolysis, which provides a new way to recognize, diagnose, and treat diseases.
Kang
Ying
Y
Department of Hematology, The Second Affiliated Hospital of Sun Yat-sen University, Guangzhou 510120, China.
Yin
Song-Mei
SM
D000818:Animals; D015703:Antigens, CD / Q000502:physiology*; D051928:CD47 Antigen; D002352:Carrier Proteins / Q000502:physiology*; D006801:Humans
D015703:Antigens, CD; D051928:CD47 Antigen; C497894:CD47 protein, human; D002352:Carrier Proteins