[From basic research to clinical results. The OVERTURE, ENABLE, and RENEWAL studies].
The results of three clinical studies (OVERTURE, ENABLE and RENEWAL), in patients with cardiac failure, are analyzed from a pharmacological point of view. In the first one of these, the action of an Angiotensin Converting Enzyme inhibitor, that at the same time inhibits the neutral endopeptidase, is studied. In the second, a blockade for endothelin cellular receptors is studied and, in the third, a synthetic acceptor of the alpha-Tumoral Necrosis Factor is taken into account. In the OVERTURE study, the benefit action of the inhibition of the Angiotensin Converting Enzyme in patients suffering from cardiac failure is confirmed, without a major effect from the neutral endopeptidase derived from its simultaneous inhibition. The other two studies were suspended because of the major side effects. The drugs used in OVERTURE, ENABLE and RENEWAL studies are relevant efforts of molecular design that, without any question, will project into the future of the therapeutic approach of cardiac failure. It is convenient to point out that in the task of designing clinical studies considering cellular signaling systems, there are other venues warranting their use in pathological or natural functions.
Pastelín Hernández
Gustavo
G
Departamento de Formacología, Instituto Nacional de Cardiología Ignacio Chávez, INCICH, Juan Badiano No. 1, Col. Sección XVI, Tlalpan, 14080 México, D.F. Gpastelín@aol.com
del Valle Mondragón
Leonardo
L
Tenorio López
Fermín Alejandro
FA
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000077300:Bosentan; D002986:Clinical Trials as Topic; D000068800:Etanercept; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*; D013841:Thiazepines / Q000627:therapeutic use*
D000806:Angiotensin-Converting Enzyme Inhibitors; D007074:Immunoglobulin G; D011725:Pyridines; D018124:Receptors, Tumor Necrosis Factor; D013449:Sulfonamides; D013841:Thiazepines; C106266:omapatrilat; D000068800:Etanercept; D000077300:Bosentan
De la investigación básica a los resultados clínicos. Estudios OVERTURE, ENABLE y RENEWAL.