Expression of hypothalamic corticotropin-releasing hormone-like immunoreactivity in isolated ACTH deficiency: a report of an autopsied case.
A 77-yr-old man died of metastising adenocarcinoma of the lung. He had been treated with hydrocortisone for isolated ACTH deficiency for 9 yr. At autopsy, the pituitary and the adrenal glands were atrophic. Lymphocyte infiltration was not observed in the pituitary, the adrenal and the thyroid glands. Immunohistochemistry revealed selective loss of ACTH-like immunoreactivity in the pituitary gland whereas CRH-immunoreactive cells were found in the paraventricular nucleus of the hypothalamus. This is the first report demonstrating immunohistochemical examinations of the pituitary and the hypothalamus in isolated ACTH deficiency.
Mori
T
T
First Division, Department of Medicine, Shimane Medical University, Izumo, Japan.
Murakami
Y
Y
Nishiki
M
M
Koshimura
K
K
Sasano
H
H
Kato
Y
Y
D000311:Adrenal Glands / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000172:deficiency*; D000368:Aged; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism*; D010902:Pituitary Gland / Q000378:metabolism / Q000473:pathology; D013961:Thyroid Gland / Q000473:pathology
D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone