Role of brain dopaminergic system in the adrenomedullin-induced diuresis and natriuresis.
Intracerebroventricular (IVT) administration of adrenomedullin (AM) to conscious male hydrated rats increases urinary volume and sodium excretion. The possible involvement of brain dopamine (DA) system on the renal action of IVT-AM was investigated. AM-induced diuretic and natriuretic action was prevented following selective central dopaminergic denervation with 6-hydroxydopamine (6OHDA) in combination with desmethylimipramine (DMI). Selective D(2) DA receptor antagonism with haloperidol, sulpiride, and remoxipride; or with the D(1) DA receptor antagonist, SCH 23390, blunted the increase in urinary volume and sodium excretion induced by IVT-AM. The present results suggest that AM acts centrally, at least in part, via an interaction with endogenous DA through the activation of both DA D(1)/D(2) receptor subtype.
Díaz
Emilia
E
Laboratory of Neuropeptides, School of Pharmacy, Universidad Central de Venezuela, Apartado Postal 50176, Sabana Grande 1050 A, Caracas, Venezuela.
Silva
María
M
Israel
Anita
A
D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology; D053607:Adrenomedullin; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D001921:Brain / Q000502:physiology*; D002395:Catecholamines / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003891:Desipramine / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects*; D004298:Dopamine / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D016627:Oxidopamine / Q000494:pharmacology; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000187:drug effects; D017448:Receptors, Dopamine D2 / Q000187:drug effects; D017330:Remoxipride / Q000494:pharmacology; D013469:Sulpiride / Q000494:pharmacology; D013565:Sympatholytics / Q000494:pharmacology
D018759:Adrenergic Uptake Inhibitors; D001552:Benzazepines; D002395:Catecholamines; D018492:Dopamine Antagonists; D010455:Peptides; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D013565:Sympatholytics; D017330:Remoxipride; D053607:Adrenomedullin; D013469:Sulpiride; D016627:Oxidopamine; D003891:Desipramine; D004298:Dopamine