title: A case of breast cancer metastasizing to cervix after resection of pancreatic metastasis.
abstract: A case of breast cancer that metastasized to the cervix 10 years and 8 months after mastectomy is reported. The patient had undergone pancreaticoduodenectomy due to solitary metastasis to the head of the pancreas 4 years previously. The cervical metastasis was associated with abnormal genital bleeding. After pancreaticoduodenectomy the serum levels of CEA, CA15-3 and NCC-ST-439, which are markers of breast cancer, were within normal limits, but the serum level of CA15-3 had increased month by month. The patient had abnormal genital bleeding and presented to the department of gynecology at our hospital. The tumor was in the cervix, bled easily and 2.5x2.0 cm in size on ultrasonography. It was thought to be carcinoma of the cervix, but biopsy revealed the tumor to be an adenocarcinoma pathologically and CA15-3 was immunohistochemically demonstrated in the resected specimen, similar to lobular carcinoma of the breast. Abdominal CT scan revealed involvement of the ovaries and uterus, prompting hysterectomy with bilateral oophorectomy. After discharge, she received chemoendocrine therapy. However, she subsequently died due to peritoneal carcinomatosis.
authors.affiliation: Department of Surgery, Hoshi General Hospital, 2-1-16 Omachi, Koriyama 963-8501, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ogino
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nomizu
authors.forename: Kenji
authors.initials: K
authors.lastname: Gonnda
authors.forename: Chiyo
authors.initials: C
authors.lastname: Okouchi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sakuma
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Yamada
authors.forename: Naoto
authors.initials: N
authors.lastname: Katagata
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Watanabe
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Takao
authors.initials: T
authors.lastname: Yoshida
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy; D001943:Breast Neoplasms / Q000473:pathology; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood; D009362:Neoplasm Metastasis; D010190:Pancreatic Neoplasms / Q000556:secondary / Q000601:surgery; D016577:Pancreaticoduodenectomy; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy
chemical_list: D018396:Mucin-1