[Prognostic significance of sex steroid and hypophyseal hormones in head and neck squamous cell carcinoma].
OBJECTIVE
to investigate the clinical outcome of HNSCC patients, and their hormonal status.


METHODS
The liver function (GGT), hypophysis gonadotrop hormone (FSH, LH, prolactin) and sexsteroid hormone serum levels were examined in 130 male HNSCC patients. Clinical parameters for age, primary tumor site and clinical tumor stage were also recorded.


RESULTS
The survival was disadvantageously influenced by the following parameters: age, the presence of lymph node metastasis, advanced tumor stage, the lower than normal testosterone and the higher than normal FSH serum levels.


CONCLUSIONS
Elevated FSH and decreased testosterone serum levels showed significant correlation with the survival of head and neck cancer patients. The better understanding of their exact role in the biology of HNSCC requires further investigations.
Remenár
Eva
E
Fej-Nyak, Allcsont, Laser és Helyreállító Plasztikai Sebészeti Osztály, Országos Onkológiai Intézet, Budapest 1122, Hungary. reva@oncol.hu
Számel
Irén
I
Budai
Barna
B
Orosz
Zsolt
Z
Gaudi
István
I
Kásler
Miklós
M
Gundy
Sarolta
S
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000473:pathology; D005640:Follicle Stimulating Hormone / Q000097:blood*; D012739:Gonadal Steroid Hormones / Q000097:blood; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010902:Pituitary Gland / Q000378:metabolism*; D011237:Predictive Value of Tests; D011379:Prognosis; D013739:Testosterone / Q000097:blood*
D012739:Gonadal Steroid Hormones; D013739:Testosterone; D005640:Follicle Stimulating Hormone
Szex szteroid- és hypophysishormonszintek prognosztikus jelentôsége fej-nyaki laphámrákban.