Engineering Plasmodium-refractory phenotypes in mosquitoes.
A remarkable number of effector mechanisms have been developed for interfering with malaria parasite development in mosquitoes. These effector mechanisms affect different aspects of parasite biology and therefore could be targeted synergistically to reduce the probability of emergence of parasite resistance to any one mechanism. The use of these mechanisms will depend on how efficiently and safely they can be introduced into existing mosquito populations.
Nirmala
Xavier
X
Department of Molecular Biology and Biochemistry, University of California, Irvine 92697-3900, USA.
James
Anthony A
AA
D000818:Animals; D030801:Animals, Genetically Modified / Q000235:genetics / Q000276:immunology* / Q000469:parasitology; D009033:Culicidae / Q000235:genetics / Q000276:immunology / Q000469:parasitology*; D007303:Insect Vectors / Q000235:genetics / Q000276:immunology / Q000469:parasitology*; D008288:Malaria / Q000517:prevention & control*; D010641:Phenotype; D010961:Plasmodium / Q000276:immunology*; D012449:Safety; D016896:Treatment Outcome