Synthesis and PGE2 inhibitory activity of vinylated and allylated chrysin analogues.
Vinylated and allylated chrysin analogues were prepared as congeners of prenylated flavonoids and evaluated their anti-inflammatory activity. 8-Substituted chrysin analogues were prepared from 2'-hydroxy-3'-iodo-4',6'-dimethoxyacetophenone in 3 steps. 3-Allylated chrysin analogues were prepared from chrysin in 3 steps. Synthesized chrysin analogues (4, 5 and 8) showed moderate inhibitory activities of PGE2 production from LPS-induced RAW 264.7 cells.
Dao
Tran Thanh
TT
College of Pharmacy, Kangwon National University, Chunchon 200-701, Korea.
Oh
Jeong Won
JW
Chi
Yeon Sook
YS
Kim
Hyun Pyo
HP
Sin
Kwan-Seog
KS
Park
Haeil
H
D000498:Allyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D051546:Cyclooxygenase 2; D015232:Dinoprostone / Q000037:antagonists & inhibitors*; D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007527:Isoenzymes / Q000378:metabolism; D051379:Mice; D015394:Molecular Structure; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D013329:Structure-Activity Relationship; D014753:Vinyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000498:Allyl Compounds; D005419:Flavonoids; D007527:Isoenzymes; D014753:Vinyl Compounds; C043561:chrysin; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D015232:Dinoprostone