title: Role of brain dopaminergic system in the adrenomedullin-induced diuresis and natriuresis.
abstract: Intracerebroventricular (IVT) administration of adrenomedullin (AM) to conscious male hydrated rats increases urinary volume and sodium excretion. The possible involvement of brain dopamine (DA) system on the renal action of IVT-AM was investigated. AM-induced diuretic and natriuretic action was prevented following selective central dopaminergic denervation with 6-hydroxydopamine (6OHDA) in combination with desmethylimipramine (DMI). Selective D(2) DA receptor antagonism with haloperidol, sulpiride, and remoxipride; or with the D(1) DA receptor antagonist, SCH 23390, blunted the increase in urinary volume and sodium excretion induced by IVT-AM. The present results suggest that AM acts centrally, at least in part, via an interaction with endogenous DA through the activation of both DA D(1)/D(2) receptor subtype.
authors.affiliation: Laboratory of Neuropeptides, School of Pharmacy, Universidad Central de Venezuela, Apartado Postal 50176, Sabana Grande 1050 A, Caracas, Venezuela.
authors.forename: Emilia
authors.initials: E
authors.lastname: Díaz
authors.forename: María
authors.initials: M
authors.lastname: Silva
authors.forename: Anita
authors.initials: A
authors.lastname: Israel
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology; D053607:Adrenomedullin; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D001921:Brain / Q000502:physiology*; D002395:Catecholamines / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D003891:Desipramine / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects*; D004298:Dopamine / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D016627:Oxidopamine / Q000494:pharmacology; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000187:drug effects; D017448:Receptors, Dopamine D2 / Q000187:drug effects; D017330:Remoxipride / Q000494:pharmacology; D013469:Sulpiride / Q000494:pharmacology; D013565:Sympatholytics / Q000494:pharmacology
chemical_list: D018759:Adrenergic Uptake Inhibitors; D001552:Benzazepines; D002395:Catecholamines; D018492:Dopamine Antagonists; D010455:Peptides; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D013565:Sympatholytics; D017330:Remoxipride; D053607:Adrenomedullin; D013469:Sulpiride; D016627:Oxidopamine; D003891:Desipramine; D004298:Dopamine