title: Iron and liver cancer.
abstract: Mechanisms whereby iron may act in carcinogenesis are induction of oxidative stress, facilitation of tumor growth, and modification of the immune system. Results of clinical and epidemiologic studies demonstrate a strong association between iron excess (even at mild levels) and the development of cancer at any site, but they do not indicate whether this reflects a causal link or an indirect association through other factors (i.e., aging, alcohol consumption, and insulin resistance). Findings obtained from experimental work are not conclusive with respect to a direct carcinogenic role of iron, but they support a carcinogenic or co-carcinogenic role of iron in chemically induced carcinogenesis.
authors.affiliation: Clinique des Maladies du Foie and Centre d'Investigation Clinique, CHU Pontchaillou, 35033 Rennes, France. yves.deugnier@univ-rennes1.fr
authors.forename: Yves
authors.initials: Y
authors.lastname: Deugnier
mesh_terms: D006432:Hemochromatosis / Q000235:genetics; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics; D006801:Humans; D007109:Immunity / Q000187:drug effects; D007501:Iron / Q000008:administration & dosage / Q000009:adverse effects; D008107:Liver Diseases / Q000150:complications; D008113:Liver Neoplasms / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008565:Membrane Proteins / Q000235:genetics; D009154:Mutation; D018384:Oxidative Stress
chemical_list: C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins; D007501:Iron