title: The stability of pseudopeptides bearing sulfoximines as chiral backbone modifying element towards proteinase K.
abstract: Incorporation of sulfoximines as backbone modifying element results in two new pseudopeptide bonds which display enhanced (bond A) and strongly reduced reactivity (bond B) towards hydrolysis by Proteinase K.
authors.affiliation: Institut für Organische Chemie, RWTH Aachen, Prof.-Pirlet-Strasse 1, D-52056 Aachen, Germany. carsten.bolm@oc.rwth-aachen.de
authors.forename: Carsten
authors.initials: C
authors.lastname: Bolm
authors.forename: Dirk
authors.initials: D
authors.lastname: Müller
authors.forename: Christian
authors.initials: C
authors.lastname: Dalhoff
authors.forename: Christian P R
authors.initials: CP
authors.lastname: Hackenberger
authors.forename: Elmar
authors.initials: E
authors.lastname: Weinhold
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000493:pharmacokinetics; D004355:Drug Stability; D019286:Endopeptidase K / Q000378:metabolism*; D009842:Oligopeptides / Q000737:chemistry* / Q000493:pharmacokinetics*; D010455:Peptides / Q000737:chemistry / Q000493:pharmacokinetics; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry* / Q000493:pharmacokinetics*
chemical_list: D000596:Amino Acids; D009842:Oligopeptides; D010455:Peptides; D013449:Sulfonamides; D019286:Endopeptidase K