title: Comparison of the antiemetic efficacy of tropisetron and droperidol with patient-given tramadol.
abstract: We compared the antiemetic efficacy of tropisetron versus droperidol in women given tramadol after total hysterectomy. Forty patients were randomly allocated to group 1 (n = 20, tropisetron 0.05 mg/kg intravenously) or group 2 (n = 20, droperidol 15 micrograms/kg intravenously). Tramadol infusion (intravenously), for post-operative analgesia, was started at fascia closure. Incidences of post-operative nausea and vomiting, pain intensity, tramadol use, and the need for a rescue antiemetic (metoclopramide 10 mg) were recorded 0 h, 2 h, 6 h, 12 h, 24 h and 48 h post-operatively. Vomiting and nausea incidences were reported fewer in group 1 than in group 2, but statistical significance was only reached for vomiting incidence 6 h post-operation. Tropisetron seems to have better antiemetic properties than droperidol in patients receiving tramadol because of the length of its duration of action. Further studies, investigating alternative ways of managing post-operative nausea and vomiting, and the use of tramadol for post-operative analgesia, are needed.
authors.affiliation: Department of Anaesthesiology, Dokuz Eylül University Hospital, Izmir, Turkey. sermin.oztekin@deu.edu.tr
authors.forename: S
authors.initials: S
authors.lastname: Oztekin
authors.forename: D
authors.initials: D
authors.lastname: Ozzeybek
authors.forename: A
authors.initials: A
authors.lastname: Taşdöğen
authors.forename: H
authors.initials: H
authors.lastname: Kilercik
authors.forename: H C
authors.initials: HC
authors.lastname: Kara
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000627:therapeutic use*; D004329:Droperidol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007211:Indoles / Q000627:therapeutic use*; D008875:Middle Aged; D009294:Narcotics / Q000008:administration & dosage / Q000627:therapeutic use*; D020250:Postoperative Nausea and Vomiting / Q000188:drug therapy*; D012646:Self Administration; D014147:Tramadol / Q000008:administration & dosage / Q000627:therapeutic use*; D000077526:Tropisetron; D014839:Vomiting / Q000188:drug therapy*
chemical_list: D000932:Antiemetics; D007211:Indoles; D009294:Narcotics; D014147:Tramadol; D000077526:Tropisetron; D004329:Droperidol