[Biological availability of ibuprofen in Imbun 500 suppositories].
Concentration of ibuprofen in rabbit blood was found to be considerably higher after application of Imbun-500 suppositories, containing 500 mg of ibuprofen lysine salt equivalent to 292.6 mg of free ibuprofen, than after application of ibuprofen dragees containing 400 mg of the free drug. Parameters characterizing biological availability of ibuprofen in Imbun-500 suppositories (AUC, Cmax, tmax) were determined. Ibuprofen lysine salt proved to be considerably more easily absorbed from suppositories than ibuprofen from dragees of either home or foreign production.
Hermann
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Katedra i Zakład Chemii Fizycznej Akademii Medycznej im. K. Marcinkowskiego w Poznaniu, ul. Swiecickiego 6, 60-781 Poznań.
Główka
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FK
D000042:Absorption; D000818:Animals; D001682:Biological Availability; D007052:Ibuprofen / Q000097:blood / Q000493:pharmacokinetics*; D011817:Rabbits; D013488:Suppositories
D013488:Suppositories; D007052:Ibuprofen
Dostepność biologiczna ibuprofenu z czopków Imbun 500.