title: Altered lymphocyte heat shock protein 70 expression in patients with HIV disease.
abstract: Heat shock protein (HSP) expression in lymphocytes isolated from 20 patients with HIV disease and 15 age-matched controls was determined. Fold increases in lymphocyte hsp70 expression after heat shock were 4.52 +/- 2.97 in HIV-positive individuals compared with 2.60 +/- 1.29 for HIV-negative controls (P= 0.001). Given clear roles for HSP in the cross-presentation of antigens, alpha-defensin internalization and pro-inflammatory cytokine production, a further investigation of HSP in HIV patients is merited.
authors.affiliation: School of Biological, Biomedical and Molecular Sciences, University of New England, Armidale, NSW 2350, Australia.
authors.forename: Linda L
authors.initials: LL
authors.lastname: Agnew
authors.forename: Mark
authors.initials: M
authors.lastname: Kelly
authors.forename: Jonathan
authors.initials: J
authors.lastname: Howard
authors.forename: Sarangapany
authors.initials: S
authors.lastname: Jeganathan
authors.forename: Marijka
authors.initials: M
authors.lastname: Batterham
authors.forename: Rosemary A
authors.initials: RA
authors.lastname: Ffrench
authors.forename: Julian
authors.initials: J
authors.lastname: Gold
authors.forename: Kenneth
authors.initials: K
authors.lastname: Watson
mesh_terms: D000328:Adult; D015153:Blotting, Western; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000097:blood* / Q000276:immunology / Q000821:virology; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D019562:Viral Load
chemical_list: D018840:HSP70 Heat-Shock Proteins