Hepatic iron overload in alcoholic liver disease: why does it occur and what is its role in pathogenesis?
Iron overload is frequently observed in alcoholic liver disease. However, it is not known why hepatic iron accumulation occurs or how it contributes to disease progression. In this review, information about the role of iron in the pathophysiology of liver disease is reviewed and discussed.
Rouault
Tracey A
TA
Section on Human Iron Metabolism, Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Building 18, Room 101, National Institutes of Health, Bethesda, MD 20892, USA. trou@helix.nih.gov
D000818:Animals; D004579:Electron Transport; D000431:Ethanol / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000493:pharmacokinetics; D019190:Iron Overload / Q000150:complications* / Q000378:metabolism; D035925:Iron-Regulatory Proteins / Q000502:physiology; D008099:Liver / Q000378:metabolism*; D008108:Liver Diseases, Alcoholic / Q000150:complications* / Q000378:metabolism; D008930:Mitochondria, Liver / Q000201:enzymology; D018384:Oxidative Stress
D035925:Iron-Regulatory Proteins; D000431:Ethanol; D007501:Iron