Managing childhood atopic dermatitis.
Atopic dermatitis, a chronic inflammatory skin disorder that affects up to 20% of school-aged children, can profoundly influence quality of life. Basic therapy consists of avoidance of triggering factors and optimal skin care. Until now, corticosteroids have been the usual treatment for acute flares. Short-term safety profiles are reasonable, but long-term use of corticosteroids may involve significant adverse effects. Topical immunomodulators (tacrolimus and pimecrolimus) are beneficial and safe for adults and children and represent a major new alternative to chronic corticosteroid use, especially in children.
Leung
Alexander K C
AK
Department of Pediatrics, University of Calgary, Alberta, Canada.
Barber
Kirk A
KA
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000485:Allergens / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D003033:Coal Tar / Q000627:therapeutic use; D003876:Dermatitis, Atopic / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D010789:Phototherapy / Q000379:methods; D012307:Risk Factors; D017592:Skin Care / Q000379:methods; D017192:Skin Diseases, Bacterial / Q000188:drug therapy / Q000209:etiology
D000276:Adjuvants, Immunologic; D000305:Adrenal Cortex Hormones; D000485:Allergens; D000900:Anti-Bacterial Agents; D006634:Histamine H1 Antagonists; D007166:Immunosuppressive Agents; D003033:Coal Tar