Tracking autoimmune T cells in diabetes.
Insulin-dependent diabetes mellitus is usually caused by the autoimmune destruction of pancreatic beta cells by T cells. Methodologies to track the development, migration, and functional activation of one class of such T cells (CD4 T cells) have been limited. However, it now appears that this limitation has been overcome.
Serreze
David V
DV
The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.
Leiter
Edward H
EH
D000818:Animals; D015551:Autoimmunity; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007515:Islets of Langerhans / Q000378:metabolism; D008285:Major Histocompatibility Complex / Q000235:genetics*; D051379:Mice; D016688:Mice, Inbred NOD; D008958:Models, Molecular; D018716:Molecular Mimicry; D019151:Peptide Library; D010455:Peptides / Q000737:chemistry / Q000276:immunology
D019151:Peptide Library; D010455:Peptides