Synthesis and PDF inhibitory activities of novel benzothiazolylidenehydroxamic acid derivatives.
A novel series of benzothiazolylidenehydroxamic acid derivatives has been designed and synthesized as PDF inhibitors. Some of this novel class of PDF inhibitors exhibited micromolar order enzyme inhibitory activity and antibacterial activity.
Takayama
Wataru
W
Research Laboratories, Senju Pharmaceutical Co., Ltd., 1-5-4 Murotani, Nishi-Ku, Kobe, Hyogo 651-2241, Japan. yingshe-cui@senju.co.jp
Shirasaki
Yoshihisa
Y
Sakai
Yusuke
Y
Nakajima
Emi
E
Fujita
Shuhei
S
Sakamoto-Mizutani
Kanako
K
Inoue
Jun
J
D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D052160:Benzothiazoles; D001665:Binding Sites / Q000187:drug effects / Q000502:physiology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D052160:Benzothiazoles; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D013844:Thiazoles; D000581:Amidohydrolases; C084507:peptide deformylase; C005465:benzothiazole