Stereotactic radiotherapy for the treatment of lymphocytic hypophysitis. Report of two cases.
Lymphocytic hypophysitis is a rare inflammatory disorder of the pituitary gland. Standard therapy consists of transsphenoidal resection or oral administration of corticosteroid medications. Two patients with symptomatic lymphocytic hypophysitis, which recurred after standard therapy, were treated with low-dose stereotactic radiotherapy. On imaging studies both lesions demonstrated a response to radiation and each patient experienced relief of symptoms. There has been no adverse sequela of the radiation treatment. The authors conclude that stereotactic radiotherapy represents an effective, noninvasive treatment option for patients with lymphocytic hypophysitis, particularly if the disease is recurrent after surgery or resistant to corticosteroid medications.
Selch
Michael T
MT
Department of Radiation Oncology, Division of Neurological Surgery, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at the University of California at Los Angeles, California 90095-6951, USA. selch@radonc.ucla.edu
DeSalles
Antonio A F
AA
Kelly
Daniel F
DF
Frighetto
Leonardo
L
Vinters
Harry V
HV
Cabatan-Awang
Cynthia
C
Wallace
Robert E
RE
Solberg
Timothy D
TD
D000368:Aged; D003131:Combined Modality Therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010900:Pituitary Diseases / Q000175:diagnosis / Q000276:immunology / Q000532:radiotherapy*; D011878:Radiotherapy / Q000379:methods*; D012008:Recurrence; D013238:Stereotaxic Techniques