title: The use of topical therapies to treat onychomycosis.
abstract: The management of onychomycosis using topical agents has improved with the introduction of ciclopirox and amorolfine nail lacquers; other topical agents may be less effective. The combination of a nail lacquer with an oral antifungal agent may further improve efficacy rates in certain clinical presentations (eg, among those individuals with severe onychomycosis). Topical agents have a favorable adverse events profile. Further studies are required on the treatment of onychomycosis with nail lacquers.
authors.affiliation: Division of Dermatology, Department of Medicine, Sunnybrook and Women's College Health Science Center (Sunnybrook Site), University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada. agupta@execulink.com
authors.forename: Aditya K
authors.initials: AK
authors.lastname: Gupta
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Ryder
authors.forename: Robert
authors.initials: R
authors.lastname: Baran
mesh_terms: D000279:Administration, Cutaneous; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000077768:Ciclopirox; D006801:Humans; D009025:Morpholines / Q000008:administration & dosage / Q000627:therapeutic use; D014009:Onychomycosis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D011728:Pyridones / Q000008:administration & dosage / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic
chemical_list: D000935:Antifungal Agents; D009025:Morpholines; D011728:Pyridones; D000077768:Ciclopirox; C038974:amorolfine