Relationship between cholecystolithiasis and polypoid gallbladder.
OBJECTIVE
To study the relationship between cholecystolithiasis and polypoid gallbladder (PLG), 260 patients with polypoid gallbladder were investigated. The patients were divided into 2 groups: group A (PLG combined with cholecystolithiasis) and group B (without cholecystolithiasis). The clinical pathological characteristics were analyzed. The intestinal epithelium metaplasia and atypical hyperplasia of the gallbladder mucosa were observed under light microscope.


RESULTS
Intestinal epithelium metaplasia and atypical hyperplasia of gallbladder mucosa were found in 47 of the 260 cases. The pathological lesions included 16 gallbladder carcinoma, 11 adenomatosis polyp, 5 myoadenoma, 7 cholesterol polyp, 4 inflammatory polyp and 4 adenomatosis hyperplasia, which occurred in 26 and 21 patients in group A and group B, i.e. 44.0% and 10.3% respectively. The difference between group A and group B was statistically significant (P<0.01).


CONCLUSIONS
Cholecystolithiasis and the succeeding inflammatory reaction is a risk-factor for the polypoid gallbladder to develop tumour.
Wu
Ai-jiao
AJ
Zhejiang University Hospital, 310027 Hangzhou, China. wuaijiang1231@sina.com
Li
Ying-qi
YQ
Du
Li-an
LA
D000293:Adolescent; D000328:Adult; D000368:Aged; D041761:Cholecystolithiasis / Q000150:complications*; D005260:Female; D005706:Gallbladder Neoplasms / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008297:Male; D008679:Metaplasia / Q000473:pathology; D008875:Middle Aged; D011123:Polyploidy; D011127:Polyps