Convenient preparations of 2,4-methanopyrrolidine and 5-carboxy-2,4-methanopyrrolidines.
An efficient four-step synthesis of N-BOC-5-syn- and 5-anti-carboxymethanopyrrolidines (12 and 13) and the conversion of 12 to N-BOC-methanopyrrolidine (2) are described.
Krow
Grant R
GR
Department of Chemistry, Temple University, Philadelphia, Pennsylvania, 19122, USA. grantkrow@aol.com
Lin
Guoliang
G
Herzon
Seth B
SB
Thomas
Andrew M
AM
Moore
Keith P
KP
Huang
Qiuli
Q
Carroll
Patrick J
PJ