title: Central nervous system-targeted complement inhibition mediates neuroprotection after closed head injury in transgenic mice.
abstract: The role of intracerebral complement activation after traumatic brain injury remains unclear. In this study, the authors demonstrate that transgenic mice with astrocyte-targeted expression of the soluble complement inhibitor sCrry have a significantly reduced neurologic impairment and improved blood-brain barrier function after closed head injury compared with wild-type C57BL/6 littermates. This work further implicates the complement system as a participant in secondary progression of brain damage after head trauma and provides a strong rationale for future studies of posttraumatic pharmacologic complement inhibition.
authors.affiliation: Department of Trauma Surgery, The Alfred Hospital and Monash University, Melbourne, Victoria, Australia.
authors.forename: Mario
authors.initials: M
authors.lastname: Rancan
authors.forename: Maria C
authors.initials: MC
authors.lastname: Morganti-Kossmann
authors.forename: Scott R
authors.initials: SR
authors.lastname: Barnum
authors.forename: Silvia
authors.initials: S
authors.lastname: Saft
authors.forename: Oliver I
authors.initials: OI
authors.lastname: Schmidt
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Ertel
authors.forename: Philip F
authors.initials: PF
authors.lastname: Stahel
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002490:Central Nervous System / Q000276:immunology*; D003167:Complement Activation; D003165:Complement System Proteins / Q000276:immunology*; D016489:Head Injuries, Closed / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018696:Neuroprotective Agents / Q000378:metabolism*; D011951:Receptors, Complement / Q000235:genetics / Q000378:metabolism*; D017463:Receptors, Complement 3b
chemical_list: C081470:Cr1l protein, mouse; D018696:Neuroprotective Agents; D011951:Receptors, Complement; D017463:Receptors, Complement 3b; D003165:Complement System Proteins