title: Dobutamine induces ineffective work in regional ischaemic myocardium: an experimental strain rate imaging study.
abstract: In the present study, we sought to investigate the effects of differing inotropic conditions on regional myocardial function in ischaemic segments. In an experimental pig model ( n =11), the regional deformation parameters peak systolic strain rate [SR(SYS) (peak velocity of thickening)], systolic strain [epsilon(SYS) (systolic wall thickening)] and post-systolic strain [epsilon(PST) (ongoing wall thickening after end of systole)] were measured during normal perfusion and regional ischaemia of the posterior wall. These parameters were compared with global contractility [E(ES) (end-systolic elastance)] measured by a conductance catheter. Ischaemia was induced by an active coronary hypoperfusion in the circumflex coronary artery. Measurements were done at baseline, during dobutamine and during esmolol infusion. In normal perfused hearts, SR(SYS) (4.8+/-0.2 s(-1) at baseline) increased during dobutamine infusion, decreased during esmolol infusion and correlated significantly with global E(ES). In addition, epsilon(SYS) averaged 93+/-3% at baseline and there was almost no epsilon(PST) (4+/-1%) in normal myocardium. In ischaemic myocardium, SR(SYS) and epsilon(SYS) were significantly reduced compared with normal myocardium at baseline (SR(SYS)=2.8+/-0.3 s(-1), and epsilon(SYS)=43+/-6%; P <0.001 compared with normal perfused hearts), whereas global E(ES) was unchanged. In contrast, epsilon(PST) was significantly increased in regional ischaemic segments compared with the non-ischaemic myocardium (15+/-2%; P <0.001). During the dobutamine infusion, SR(SYS) remained unchanged. In contrast, epsilon(SYS) decreased (25+/-5%; P <0.001) and epsilon(PST) increased (25+/-4%; P <0.05) significantly during dobutamine infusion in ischaemic myocardium. In ischaemic segments, an inotropic stimulation with dobutamine resulted in a shift of strain from systole (epsilon(SYS)) to post-systole (epsilon(PST)). Thus dobutamine induced ineffective myocardial work in ischaemic segments.
authors.affiliation: Medical University Clinic, Josef-Schneider Str. 2, 97080 Würzburg, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Weidemann
authors.forename: Jens
authors.initials: J
authors.lastname: Broscheit
authors.forename: Nicole
authors.initials: N
authors.lastname: Eberbach
authors.forename: Paul
authors.initials: P
authors.lastname: Steendijk
authors.forename: Wolfram
authors.initials: W
authors.lastname: Voelker
authors.forename: Clemens
authors.initials: C
authors.lastname: Greim
authors.forename: Georg
authors.initials: G
authors.lastname: Ertl
authors.forename: Norbert
authors.initials: N
authors.lastname: Roewer
authors.forename: Jörg M
authors.initials: JM
authors.lastname: Strotmann
mesh_terms: D000319:Adrenergic beta-Antagonists; D000818:Animals; D002316:Cardiotonic Agents; D004280:Dobutamine; D004452:Echocardiography; D023421:Models, Animal; D009200:Myocardial Contraction / Q000187:drug effects*; D017202:Myocardial Ischemia / Q000503:physiopathology*; D010477:Perfusion; D011412:Propanolamines; D013314:Stress, Mechanical; D013318:Stroke Volume; D013556:Swine, Miniature
chemical_list: D000319:Adrenergic beta-Antagonists; D002316:Cardiotonic Agents; D011412:Propanolamines; D004280:Dobutamine; C036604:esmolol