6-month evaluation of JinHuang Chinese herbal medicine study in asymptomatic HIV infected Thais.
Good results of in vitro study of anti-HIV effects of JinHuang, a Chinese herbal medicine led to in vivo study of safety and efficacy among asymptomatic HIV infected individuals. It was a prospective open study of 21 asymptomatic HIV infected Thai volunteers. Twelve and 9 were female and male, respectively, with mean age of 29.24 +/- 3.94 years. JinHuang preparation, 6 capsules and 2 bottles of liquid formula orally three times a day, was given on an outpatient basis initially for 6 months. Regular close monitoring and follow-up were done. The side effects reported included : increased bowel movements (81%), vague taste, and smell of drug after initiation (52%). No serious adverse event related to JinHuang was detected during study. No significant changes in terms of log viral load and CD4 count were observed after 6-months' duration. Most of the patients felt that the quality of life was better in terms of better appetite, good sleep and healthy during study participation, however, these were subjective.
Maek-a-nantawat
Wirach
W
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
Pitisuttithum
Punnee
P
Bussaratid
Valai
V
Chamnachanan
Supat
S
Naksrisook
Supa
S
Peonim
Wantanee
W
Thantamnu
Narumon
N
Muanaum
Rungrapat
R
Ngamdee
Vatcharachai
V
D000328:Adult; D015992:Body Mass Index; D018791:CD4 Lymphocyte Count; D004365:Drugs, Chinese Herbal / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D017567:Karnofsky Performance Status; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy / Q000009:adverse effects; D011446:Prospective Studies; D013785:Thailand; D019562:Viral Load
D004365:Drugs, Chinese Herbal