Dose- and duration-dependent alterations by tellurium on lipid levels: differential effects in cerebrum, cerebellum, and brain stem of mice.
The effect of various doses of sodium tellurite (1/50 LD50=0.4 mg/kg, 1/25 LD50=0.8 mg/kg, and 1/10 LD50=2.0 mg/kg body weight orally) on the lipid levels (cholesterol, triglycerides, phospholipids, esterified fatty acids, gangliosides, and total lipids) in the cerebrum, cerebellum, and brainstem of male albino mice was studied after 7 and 15 d of treatment. Sodium tellurite (2.0 mg/kg body weight) for 7 d has an apparent effect on the depletion of cholesterol, triglycerides, phospholipids, esterified fatty acids, and total lipids. The cholesterol content was decreased significantly in the cerebrum, cerebellum, and brainstem after 7 d of treatment with a 2.0-mg/kg dose compared to the control. On the other hand, treatment for 15 d with doses of 0.4, 0.8, and 2.0 mg/kg body weight resulted in a significant and dose-dependent increment in cholesterol level in the cerebrum, cerebellum, and brainstem. The triglycerides content was decreased significantly in the cerebrum, cerebellum, and brainstem with the 2.0-mg/kg dose after 7 d of treatment. The doses of 0.4, 0.8, and 2.0 mg/kg orally for 15 d resulted in a significant and dose-dependent depletion of triglycerides in the cerebrum, cerebellum, and brainstem. All the doses of tellurium (0.4, 0.8, and 2.0 mg/kg) both for 7 and 15 d have depleted the level of phospholipids in varying degrees of significance in the cerebrum, cerebellum, and brainstem. However, the level of esterified fatty acids was decreased significantly with the 2.0-mg/kg dose of tellurium for 7 d but increased with the 0.4-mg/kg dose for 15 d in the cerebrum and cerebellum. The level of gangliosides was depleted in the cerebrum but elevated in the cerebellum and brainstem after receiving a 2.0-mg/kg dose of sodium tellurite for 7 d. The content of gangliosides was increased with doses of 0.4 and 0.8 mg/kg but decreased with 2.0 mg/kg for 15 d in the cerebrum, cerebellum, and brainstem. The total lipids content was depleted significantly and dose dependently after 7 and 15 d of treatment in the cerebrum, cerebellum, and brainstem. These results suggest that sodium tellurite affects the lipids content differentially in various parts of the mice brain.
Kaur
Parvinder
P
Neurotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi-110 062, India.
Yousuf
Seema
S
Ansari
Mubeen Ahmad
MA
Ahmad
Abdullah Shafique
AS
Islam
Fakhrul
F
D000818:Animals; D001933:Brain Stem / Q000187:drug effects* / Q000378:metabolism; D002531:Cerebellum / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000134:cerebrospinal fluid / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000134:cerebrospinal fluid / Q000378:metabolism; D005732:Gangliosides / Q000134:cerebrospinal fluid / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D051379:Mice; D010743:Phospholipids / Q000134:cerebrospinal fluid / Q000378:metabolism; D013687:Telencephalon / Q000187:drug effects* / Q000378:metabolism; D013691:Tellurium / Q000008:administration & dosage / Q000494:pharmacology*; D014280:Triglycerides / Q000134:cerebrospinal fluid / Q000378:metabolism
D005227:Fatty Acids; D005732:Gangliosides; D010743:Phospholipids; D014280:Triglycerides; C032039:sodium tellurate(IV); D002784:Cholesterol; D013691:Tellurium