Pattern of chloroquine-induced pruritus in antenatal patients at the University College Hospital, Ibadan.
The importance of Malaria, especially in pregnancy, cannot be over-emphasised. A major determinant of compliance with treatment in this environment is the pruritus chloroquine induces when ingested. This cross-sectional study of 200 antenatal patients was aimed at obtaining the pattern of the pruritus in antenatal patients. The prevalence of chloroquine-induced pruritus was 64.5%; 76.3% of the patients experienced the itching within 24 hours of ingestion of the drug and 60% of the patients still use the drug in spite of the itching for various reasons. Among the indices of severity, the frequency of itching with chloroquine use was the only factor that correlated with continuation of use (P < 0.01).
Olayemi
O
O
Department of Obstetrics and Gynaecology, College of Medicine, University College Hospital, Ibadan, Nigeria.
Fehintola
F A
FA
Osungbade
A
A
Aimakhu
C O
CO
Udoh
E S
ES
Adeniji
A R
AR
D000328:Adult; D000962:Antimalarials / Q000009:adverse effects*; D002738:Chloroquine / Q000009:adverse effects*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011537:Pruritus / Q000139:chemically induced* / Q000188:drug therapy
D000962:Antimalarials; D002738:Chloroquine