Effect of proinflammatory cytokines (IL-6, TNF-alpha, IL-1beta) on hemodynamic performance during orthotopic liver transplantation.
BACKGROUND
Proinflammatory cytokines (IL-6, IL-1beta, TNF-alpha) released during liver transplantation may affect hemodynamic stability. The aim of the present study was to analyze the association between IL-6, TNF-alpha, and IL-1beta and systemic vascular resistance during the phases of liver transplantation.


METHODS
The proinflammatory cytokines IL-6, IL-1beta, and TNF-alpha were analyzed in the blood of 20 consecutive patients who underwent transplantation. Blood samples were drawn from the pulmonary artery at serial times during surgery. Hemodynamic parameters were determined using a cardiac output monitor. Correlations between parameters were analyzed using the Spearman's rho and Kendall's tau-b methods.


RESULTS
Both in the vena cava and the pulmonary artery, significant association was observed between basal values of IL-6 during hepatectomy and systemic vascular resistance during the phases of liver transplantation: hepatectomy phase (r=.76, P=.02), anhepatic phase (r=.78, P=.03) and reperfusion phase (r=.87, P=.005).


CONCLUSIONS
Basal values of IL-6 may be considered a prognostic factor for hemodynamic performance during the phases of liver transplantation.
Arranz
J
J
Liver Transplant Unit, Research Unit, University Hospital Clinic (Barcelona), University Hospital NS de Candelaria, Tenerife, Spain. javierar@teleline.es
Soriano
A
A
Garcia
I
I
García
I
I
Concepción
M T
MT
Navarro
J
J
Arteaga
A
A
Filella
X
X
Bravo
P
P
Barrera
M
M
Escribano
S
S
Jiménez
A
A
Moneva
E
E
Fernandez
J
J
Varona
A
A
Herrero
E
E
Dominguez
D
D
D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002302:Cardiac Output; D016207:Cytokines / Q000097:blood*; D006339:Heart Rate; D006439:Hemodynamics / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D016031:Liver Transplantation / Q000276:immunology* / Q000379:methods / Q000502:physiology; D016343:Monitoring, Intraoperative; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D014655:Vascular Resistance / Q000276:immunology
D015415:Biomarkers; D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha