title: Asymmetric catalysis with chiral ferrocene ligands.
abstract: Chiral ferrocene ligands have been widely used in asymmetric catalysis. The advantages of using ferrocene as a scaffold for chiral ligands are described, particularly those regarding planar chirality, rigid bulkiness, and ease of derivatization. The role of planar chirality in 1,2- and 1,1'-disubstituted ferrocene systems is discussed. By using a bulky ferrocene fragment, novel ferrocene ligands were designed, and high enantioselectivity and regioselectivity were achieved in the allylic substitution reaction of monosubstituted allyl substrates. Using the tunable electronic properties of a diphosphine-oxazoline ferrocenyl ligand, the regioselectivity of the intermolecular asymmetric Heck reaction was also examined.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China.
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Dai
authors.forename: Tao
authors.initials: T
authors.lastname: Tu
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: You
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Deng
authors.forename: Xue-Long
authors.initials: XL
authors.lastname: Hou