title: Influence of human leukocyte antigen-B22 alleles on the course of human immunodeficiency virus type 1 infection in 3 cohorts of white men.
abstract: The human leukocyte antigen (HLA)-B22 serogroup--which consists of the alleles B*54, B*55, and B*56--has been associated with rapidly progressive disease in white patients with human immunodeficiency virus (HIV) infection. Subjects from 3 cohorts of men who have sex with men (N=671), all of whom experienced HIV-1 seroconversion at roughly the same time, were molecularly typed at HLA-A, -B, and -C loci. Mean HIV RNA loads during early HIV infection were higher in B22-positive men than in B22-negative men (difference, 0.481 log(10) HIV RNA copies/mL; 95% confidence interval [CI], 0.156-0.806 log(10) HIV RNA copies/mL; P=.004). Independent of accepted markers of progression, time-to-AIDS was shorter in B22-positive seroconverters (adjusted hazard ratio, 1.98; 95% CI, 1.27-3.10; P=.003). White B22 serogroup alleles (B*55 and *56) appear to predispose to unfavorable outcome of HIV infection as strongly as some or all B*35 and B*53 alleles. This finding may have greater implications for Asians, because the marker frequency for B22 is higher among Asians than among whites (approximately 10% vs. approximately 4%).
authors.affiliation: Department of Epidemiology, University of Alabama at Birmingham, Alabama, USA.
authors.forename: M Tevfik
authors.initials: MT
authors.lastname: Dorak
authors.forename: Jianming
authors.initials: J
authors.lastname: Tang
authors.forename: Shenghui
authors.initials: S
authors.lastname: Tang
authors.forename: Ana
authors.initials: A
authors.lastname: Penman-Aguilar
authors.forename: Roel A
authors.initials: RA
authors.lastname: Coutinho
authors.forename: James J
authors.initials: JJ
authors.lastname: Goedert
authors.forename: Roger
authors.initials: R
authors.lastname: Detels
authors.forename: Richard A
authors.initials: RA
authors.lastname: Kaslow
mesh_terms: D000328:Adult; D000483:Alleles; D015331:Cohort Studies; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics* / Q000503:physiopathology*; D015497:HIV-1 / Q000472:pathogenicity; D015235:HLA-B Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D016016:Proportional Hazards Models; D012367:RNA, Viral / Q000097:blood; D019562:Viral Load; D044465:White People
chemical_list: D015235:HLA-B Antigens; C105903:HLA-B22 antigen; D012367:RNA, Viral