Protective effect of sesamin administration on exercise-induced lipid peroxidation.
To investigate the mechanism of antioxidative effects of sesamin in vivo, 32 male ddY mice were administered with 10 mg/kg or 100 mg/kg of sesamin (S10, S100), 100 mg/kg of vitamin E (VE100) or control sample (C). They were subjected to 30 min of swimming exercise 2 h after the sample administration by using a new forced-swimming apparatus, i. e. an adjustable-current swimming pool. Exercise resulted in a significant increase in plasma lipid peroxides (LPO) in C and VE100 (p < 0.01), but not in S10 and S100. S100 showed significantly higher total glutathione peroxidase activity and glutathione S-transferase activity in liver compared to C (p < 0.05). In conclusion, sesamin may enhance LPO degradation in the liver resulting in the strong protective effects against exercise-induced plasma lipid peroxidation.
Ikeda
T
T
Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan.
Nishijima
Y
Y
Shibata
H
H
Kiso
Y
Y
Ohnuki
K
K
Fushiki
T
T
Moritani
T
T
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004149:Dioxoles / Q000494:pharmacology*; D004789:Enzyme Activation; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D017705:Lignans / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D051379:Mice; D010805:Physical Conditioning, Animal
D000975:Antioxidants; D004149:Dioxoles; D017705:Lignans; D008054:Lipid Peroxides; D005979:Glutathione Peroxidase; C054125:sesamin