title: Treatment of complications after breast-conservation therapy.
abstract: Over the past 2 decades, breast-conservation therapy with lumpectomy and whole-breast radiotherapy has become a standard option for the majority of women with newly diagnosed breast cancer. Long-term local control is achieved in approximately 85% of patients, and the therapy is generally well tolerated. There can, however, be long-term effects on the breast and other nearby tissues that may range from asymptomatic findings on examination to severe, debilitating problems. Infection, fat necrosis, and severe musculoskeletal problems such as osteoradionecrosis or soft-tissue necrosis are uncommon, affecting less than 5% of patients. However, changes in range of motion, mild-to-moderate musculoskeletal pain, and arm and breast edema are much more common. As more women choose breast-conservation therapy for management of their breast cancer, physicians will encounter these problems, as well as in-breast tumor recurrence, with greater frequency. This review will focus on the incidence, contributing factors, and management of the late problems of infection, fat necrosis, musculoskeletal complications, and local recurrence following breast-conservation therapy.
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Department of Radiation Oncology, Baltimore, Maryland, USA. frassde@jhmi.edu
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Frassica
authors.forename: Gopal K
authors.initials: GK
authors.lastname: Bajaj
authors.forename: Theodore N
authors.initials: TN
authors.lastname: Tsangaris
mesh_terms: D000038:Abscess / Q000209:etiology / Q000628:therapy; D001941:Breast Diseases / Q000209:etiology* / Q000628:therapy; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D002481:Cellulitis / Q000209:etiology / Q000628:therapy; D003131:Combined Modality Therapy; D005218:Fat Necrosis / Q000209:etiology / Q000628:therapy; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D009140:Musculoskeletal Diseases / Q000209:etiology / Q000628:therapy; D010146:Pain / Q000188:drug therapy / Q000209:etiology; D011183:Postoperative Complications / Q000209:etiology / Q000628:therapy*; D012008:Recurrence