Gender differences in the metabolism of benzene, toluene and trichloroethylene in rat with special reference to certain biochemical parameters.
Metabolites viz. phenol, hippuric acid and total trichloro compounds of benzene, toluene and trichloroethylene respectively were estimated in the urine samples of male and female rats after exposure for a period of 30 days. The results exhibited higher metabolism in female rats than the male rats. Their metabolism might be regulated by cytochrome P450 isozymes in a gender specific manner. However, sex differences in the activity of glutathione-S-transferases of the liver have also been found to determine their toxicity. Results have been discussed with quantitative profiles of other enzymes established in the liver of male and female rats.
Verma
Yeshvandra
Y
Toxicology Laboratory, Department of Zoology, Ch. Charan Singh University, Meerut-250 004, India.
Rana
S V S
SV
D000818:Animals; D001554:Benzene / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000494:pharmacology; D004785:Environmental Pollutants / Q000378:metabolism*; D005260:Female; D005982:Glutathione Transferase / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D012997:Solvents / Q000378:metabolism*; D014050:Toluene / Q000378:metabolism*; D014241:Trichloroethylene / Q000378:metabolism*
D004785:Environmental Pollutants; D012997:Solvents; D014241:Trichloroethylene; D014050:Toluene; D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase; D001554:Benzene