A cytokine in the Drosophila stress response.
The fruit fly, Drosophila melanogaster, has become a popular tool for studying immediate reactions to environmental hazards, such as the heat shock and innate immune responses. In mammals, protective responses to infections and other insults are coordinated by a complex network of cytokines that mediate cell-to-cell signaling. By contrast, the corresponding heat shock and innate immune responses in Drosophila have usually been regarded as cell-autonomous processes. However, in this issue of Developmental Cell, show that cytokines do play a role in mediating an acute phase response in this organism.
Hultmark
Dan
D
Umeå Centre for Molecular Pathogenesis, Umeå University, S-901 87, Umeå, Sweden.
Ekengren
Sophia
S
D000818:Animals; D016207:Cytokines / Q000502:physiology*; D004331:Drosophila melanogaster / Q000502:physiology*; D005786:Gene Expression Regulation; D006360:Heat-Shock Proteins / Q000502:physiology; D018869:Heat-Shock Response / Q000502:physiology*; D007113:Immunity, Innate / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D013312:Stress, Physiological / Q000378:metabolism*
D016207:Cytokines; D006360:Heat-Shock Proteins