Vascular effects of step I diet in hypercholesterolemic patients with coronary artery disease.
We administered a step I diet to 50 hypercholesterolemic patients with coronary artery disease during 12 weeks. Compared with baseline, the step I diet significantly changed lipoprotein levels, significantly improved the percent flow-mediated dilation response to hyperemia by 32 +/- 7% (p <0.001), increased plasma levels of nitrate by 45 +/- 12% (p = 0.013), and lowered plasma levels of malondialdehyde by 7 +/- 4% (p = 0.011). However, the step I diet did not significantly change serologic markers of inflammation, plaque stability, and thrombosis. Step I diet therapy improved endothelium-dependent vasodilation with an increase in plasma nitrogen oxide and a decrease in oxidant stress in hypercholesterolemic patients with coronary artery disease.
Koh
Kwang Kon
KK
Vascular Medicine and Atherosclerosis Unit, Department of Cardiology, Gil Heart Center, Gachon Medical School, 1198 Kuwol-dong, Namdong-gu, Incheon, Korea. kwangk@ghil.com
Ahn
Jeong Yeal
JY
Choi
Yu Mi
YM
Han
Seung Hwan
SH
Kim
Dae Sung
DS
Kim
Hyung Sik
HS
Ahn
Tae Hoon
TH
Choi
In Suck
IS
Shin
Eak Kyun
EK
D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology*; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000178:diet therapy* / Q000503:physiopathology*; D018836:Inflammation Mediators / Q000097:blood; D008074:Lipoproteins / Q000097:blood / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009566:Nitrates / Q000097:blood; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology*; D014666:Vasomotor System / Q000187:drug effects / Q000503:physiopathology
D018836:Inflammation Mediators; D008074:Lipoproteins; D009566:Nitrates; D008315:Malondialdehyde