Trials, tribulations and finally, a transporter: the identification of the mitochondrial pyruvate transporter.
Pyruvate occupies a central role in energy homoeostasis, and dysregulation of its cellular disposition underlies many metabolic disturbances. Although the mitochondrial membrane pyruvate transporter has been characterized, its molecular identity has proved elusive. Recent work has now identified a single candidate protein for the mitochondrial pyruvate carrier in yeast, opening the way for further studies in mammalian systems, which may have important therapeutic applications within the context of metabolic disease.
Sugden
Mary C
MC
Centre for Diabetes and Metabolic Medicine, Institute of Cell and Molecular Sciences, Barts and the London, Queen Mary's School of Medicine and Dentistry, University of London, London, UK. m.c.sugden@qmul.ac.uk
Holness
Mark J
MJ
D000818:Animals; D027321:Anion Transport Proteins; D006801:Humans; D026901:Membrane Transport Proteins / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification*; D033681:Mitochondrial Membrane Transport Proteins; D024101:Mitochondrial Proteins / Q000737:chemistry* / Q000235:genetics / Q000302:isolation & purification*; D027501:Monocarboxylic Acid Transporters; D019289:Pyruvic Acid / Q000737:chemistry* / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification
D027321:Anion Transport Proteins; C573715:FMP37 protein, S cerevisiae; C573718:MPC1 protein, human; D026901:Membrane Transport Proteins; D033681:Mitochondrial Membrane Transport Proteins; D024101:Mitochondrial Proteins; D027501:Monocarboxylic Acid Transporters; D029701:Saccharomyces cerevisiae Proteins; D019289:Pyruvic Acid