Possible association between -G308A tumour necrosis factor-alpha gene polymorphism and major depressive disorder in the Korean population.
OBJECTIVE
The present study was aimed at examining the association between the -G308A tumour necrosis factor-alpha gene polymorphism and major depressive disorder (MDD) in the Korean population.


METHODS
One hundred and eight in-patients with MDD and 125 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism.


RESULTS
Genotype and allele distributions in patients with MDD (P=0.024 and P=0.0125, respectively), were significantly different from those of the controls. In particular, subjects with MDD had an increased frequency of the TNF2 (A) allele.


CONCLUSIONS
The present study suggests that the -G308A tumour necrosis factor-alpha gene polymorphism may have a potential role for susceptibility to MDD in the Korean population.
Jun
Tae-Youn
TY
Department of Psychiatry, Kangnam St Mary's Hospital, The Catholic University of Korea College of Medicine, 505 Banpo-Dong, Seocho-Gu, Seoul 137-401, Korea.
Pae
Chi-Un
CU
Hoon-Han
Chae
Jeong-Ho
JH
Bahk
Won-Myong
WM
Kim
Kwang-Soo
KS
Serretti
Alessandro
A
D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D017931:DNA Primers; D003866:Depressive Disorder / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012016:Reference Values; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D017931:DNA Primers; D014409:Tumor Necrosis Factor-alpha