Factor XII deficiency is strongly associated with primary recurrent abortions.
OBJECTIVE
To evaluate factor XII deficiency in women with primary and secondary recurrent abortion.


METHODS
Prospective case-control study.


METHODS
University hospital.


METHODS
Sixty-seven women with primary and 33 women with secondary recurrent abortion of unexplained nature and 49 healthy controls with no history of thrombotic disease or adverse pregnancy outcomes. MAIL OUTCOME MEASURE(S): Plasma factor XII activity, activated protein C resistance, factor V Leiden mutation analysis, protein C, protein S, antithrombin III, karyotyping, and anticardiolipin antibodies.


RESULTS
Ten of 67 women with primary recurrent abortion (14.9%) and 4 of 33 women (12.1%) with secondary recurrent abortion had reduced factor XII activity (<60%). These results are highly significant in the former group and showed a tendency toward significance in the latter group. All controls had normal factor XII activity.


CONCLUSIONS
Factor XII deficiency is strongly associated with primary recurrent abortion, and women with secondary recurrent abortion show a tendency toward factor XII deficiency.
Pauer
Hans-Ulrich
HU
Department of Gynecology and Obstetrics, University Hospital of Goettingen, Goettingen, Germany. hpauer@gwdg.de
Burfeind
Peter
P
Köstering
Heinz
H
Emons
Günter
G
Hinney
Bernd
B
D000026:Abortion, Habitual / Q000150:complications*; D020016:Activated Protein C Resistance / Q000235:genetics; D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood; D001778:Blood Coagulation Disorders / Q000150:complications; D016022:Case-Control Studies; D020732:Cytogenetic Analysis; D005165:Factor V / Q000235:genetics; D005175:Factor XII Deficiency / Q000150:complications* / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology; D005260:Female; D006801:Humans; D015995:Prevalence; D011446:Prospective Studies; D014599:Uterus / Q000002:abnormalities
D017152:Antibodies, Antiphospholipid; C095381:factor V Leiden; D005165:Factor V