Tissue reactions to a component of root canal system bacteria: lipoteichoic acid.
Lipoteichoic acid (LTA), present in Gram-positive microorganisms, has physiochemical characteristics that allow it to act as an immunogen. Due to polymicrobial characteristics of root canal infections, LTA can participate in the development of periapical disease. The reaction of the rat subcutaneous tissue to Teflon tube implants, filled with Fibrinol soaked in lipoteichoic acid (concentration of 150 microg/ml), was observed. Lipoteichoic acid provoked an inflammatory tissue reaction.
Costa
Edson Dias Júnior
ED
Division of Endodontics, Faculty of Dentistry, University of Brasília, Brasília, DF, Brazil. edsondias@opengate.com.br
de Souza-Filho
Francisco José
FJ
Barbosa
Sérgio Valmor
SV
D000818:Animals; D001421:Bacteria, Anaerobic / Q000737:chemistry; D003788:Dental Pulp Diseases / Q000382:microbiology; D013293:Enterococcus faecalis / Q000737:chemistry; D007249:Inflammation / Q000139:chemically induced*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D018375:Neutrophil Activation; D051381:Rats; D017208:Rats, Wistar; D040521:Subcutaneous Tissue / Q000187:drug effects; D013682:Teichoic Acids / Q000494:pharmacology*
D008070:Lipopolysaccharides; D013682:Teichoic Acids; C009900:lipoteichoic acid