Prevalence of the mitochondrial DNA A1555G mutation in sensorineural deafness patients in island Southeast Asia.
A mtDNA A1555G base substitution in a highly conserved region of the 12S rRNA gene has been reported to be the main cause of aminoglycoside induced deafness. This mutation is found in approximately 3% of Japanese and 0.5-2.4% of European sensorineural deafness patients. We report a high prevalence (5.3%) of the A1555G mutation in sensorineural deafness patients in Sulawesi (Indonesia). Our result confirms the importance of determining the prevalence of the mtDNA A1555G mutation in different populations, and the need for mutation detection before the administration of aminoglycoside antibiotics.
Malik
Safarina G
SG
Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, 10430, Jakarta , Indonesia.
Pieter
Nova
N
Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, 10430, Jakarta , Indonesia.|Department of Ear, Nose and Throat, University of Hasanuddin, Jl. Perintis Kemerdekaan KM 10, 90245, Makassar , Indonesia.
Sudoyo
Herawati
H
Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, 10430, Jakarta , Indonesia.
Kadir
Abdul
A
Department of Ear, Nose and Throat, University of Hasanuddin, Jl. Perintis Kemerdekaan KM 10, 90245, Makassar , Indonesia.
Marzuki
Sangkot
S
Eijkman Institute for Molecular Biology, Jl. Diponegoro 69, 10430, Jakarta , Indonesia. smarzuki@eijkman.go.id.
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D004252:DNA Mutational Analysis; D017931:DNA Primers / Q000737:chemistry; D004272:DNA, Mitochondrial / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D006319:Hearing Loss, Sensorineural / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D008875:Middle Aged; D008928:Mitochondria / Q000235:genetics; D009154:Mutation / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012313:RNA; D000077278:RNA, Mitochondrial; D012335:RNA, Ribosomal / Q000235:genetics*
D017931:DNA Primers; D004272:DNA, Mitochondrial; D000077278:RNA, Mitochondrial; D012335:RNA, Ribosomal; C075526:RNA, ribosomal, 12S; D012313:RNA