Inhibitory effects of Xanthii fructus extract on mast cell-mediated allergic reaction in murine model.
The effect of aqueous extract of Xanthii fructus (XF) on mast cell-mediated allergic reaction has been investigated. XF inhibited compound 48/80-induced systemic anaphylaxis in mouse. This dose-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) by compound 48/80. Additionally, XF inhibited local immunoglobulin E (IgE)-mediated passive cutaneous anaphylatic reaction. When XF (0.1mg/ml) was added, the secretion of tumor necrosis factor-alpha (TNF-alpha) from anti-dinitrophenyl (DNP) IgE antibody-stimulated mast cells was inhibited by 56%. Our studies provide evidence that XF may be beneficial in the treatment of various types allergic diseases.
Hong
Seung-Heon
SH
Department of Oriental Pharmacy, College of Pharmacy, VCRC of Wonkwang University, Iksan, Jeonbuk 570-749, South Korea.
Jeong
Hyun-Ja
HJ
Kim
Hyung-Min
HM
D000707:Anaphylaxis / Q000188:drug therapy* / Q000276:immunology; D000818:Animals; D018926:Anti-Allergic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D004140:Dinitrophenols / Q000276:immunology; D004195:Disease Models, Animal; D004306:Dose-Response Relationship, Immunologic; D006636:Histamine Release / Q000187:drug effects; D007073:Immunoglobulin E / Q000008:administration & dosage; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D003189:p-Methoxy-N-methylphenethylamine / Q000008:administration & dosage
D018926:Anti-Allergic Agents; D004140:Dinitrophenols; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D007073:Immunoglobulin E; D003189:p-Methoxy-N-methylphenethylamine