Rapid and efficient microwave-assisted amination of electron-rich aryl halides without a transition-metal catalyst.
[reaction: see text] A rapid and direct amination of aryl halides has been developed in good to high yields under microwave irradiation without a transition-metal catalyst. This reaction is a particularly powerful method for the coupling of electron-rich aryl halides with various amines. In some cases, the excellent regioselectivity could be observed, which facilitated the preparation of meta-substituted anilines from ortho- or para-substituted phenylhalides. In addition, a mechanism via the interesting benzyne intermediate has been proposed.
Shi
Lei
L
Department of Chemistry & State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China.
Wang
Min
M
Fan
Chun-An
CA
Zhang
Fu-Min
FM
Tu
Yong-Qiang
YQ