Mechanisms of sarcoma development.
Sarcomas are a rare and diverse group of tumours that are derived from connective tissues, including bone, muscle and cartilage. Although there are instances of hereditary predisposition to sarcomas, the overwhelming majority of such tumours are sporadic. In the past decade, we have gained much insight into the genetic abnormalities that seem to underlie the pathogenesis of these tumours. This information has already led to new classification of many sarcomas, as well as to successful therapies that are targeted at specific genetic abnormalities. It is likely that this approach will lead to continued refinements in classification and treatment of these tumours.
Helman
Lee J
LJ
Molecular Oncology Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 13N240, MSC 1928, Bethesda, Maryland 20892-1928, USA. helmanl@nih.gov
Meltzer
Paul
P
D000818:Animals; D006801:Humans; D023421:Models, Animal; D009372:Neoplasms, Connective Tissue / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D012509:Sarcoma / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D014178:Translocation, Genetic / Q000235:genetics*