title: Inhibition of lens epithelial cell migration at the intraocular lens optic edge: role of capsule bending and contact pressure.
abstract: OBJECTIVE
  To evaluate the inhibitory effect of a sharp intraocular lens (IOL) optic edge, a sharp capsule bend, and contact pressure between the optic edge and posterior capsule on lens epithelial cell (LEC) migration.
  
  
  METHODS
  Department of Ophthalmology, Kyorin University, Tokyo, Japan.
  
  
  METHODS
  This in vitro laboratory study evaluated a tumble-polished convex-plano IOL (CP group), an AcrySof IOL (Alcon) with a sharp edge (AS group), a new IOL with a round ridge (RR group), and a new IOL with a sharp ridge (SR group). The 2 new IOLs have high ridges and high angled loops that create firm contact between the ridge and posterior capsule. After sham cataract surgery, an IOL and a capsular tension ring (CTR) were implanted in the capsular bag of rabbit eyes. The extracted capsular bags containing the CTR and IOL were cultured. The inhibitory effect of each IOL on cell migration was analyzed. Furthermore, LEC migration on the posterior capsule was compared in culture between capsules having a sharp right angle and those with gradually curving bends.
  
  
  RESULTS
  The inhibitory effect on cell migration was statistically greatest in the SR group followed by the RR, AS, and CP groups. A sharp capsule bend did not inhibit cell migration.
  
  
  CONCLUSIONS
  The results suggest that inhibition of cell migration at the optic edge is regulated by the degree of contact pressure between the optic edge and posterior capsule. A sharp capsule bend might indicate strong contact but does not in itself inhibit cell migration.
authors.affiliation: Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan. nagamoto@qc4.so.net.ne.jp
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Nagamoto
authors.forename: Takaaki
authors.initials: T
authors.lastname: Fujiwara
mesh_terms: D000818:Animals; D002464:Cell Migration Inhibition; D002465:Cell Movement / Q000502:physiology*; D004847:Epithelial Cells / Q000502:physiology*; D007903:Lens Capsule, Crystalline / Q000502:physiology*; D007908:Lens, Crystalline / Q000166:cytology*; D007910:Lenses, Intraocular; D011312:Pressure; D011474:Prosthesis Design; D011817:Rabbits; D013552:Swine