Dynamic combinatorial chemistry: a new method for selection and preparation of synthetic receptors.
In a dynamic combinatorial library, all compounds are in thermodynamic equilibrium, allowing the library composition to adapt to external influences. Thus, non-covalent forces between a ligand and its receptor can be used to select, stabilize and, thereby, amplify the best receptor in the library. Ligand-induced amplification can be a means of receptor synthesis. Dynamic combinatorial chemistry facilitates access to new receptors, including highly flexible induced-fit receptors and structurally complex capsule-like receptors that are difficult to access using traditional methods. Recently, dynamic combinatorial chemistry has also been used to identify and prepare catalytically active receptors.
Otto
Sijbren
S
University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, CB2 1EW, UK. so230@cam.ac.uk
D000818:Animals; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D006801:Humans; D011955:Receptors, Drug / Q000187:drug effects*
D011955:Receptors, Drug