Cation transport by a redox-active synthetic ion channel.
The synthesis, cation binding and transmembrane conductive properties of a novel group of synthetic ion channels containing a redox-active centre are described. Experiments using a black lipid membrane preparation revealed that these compounds function effectively as ion channels. Subsequent 23Na NMR spectroscopy studies focused on a synthesized ion channel with a ferrocene centre. When incorporated in vesicular bilayers, this channel was demonstrated to support a Na+ flux that was at least six times faster than ion transport by monensin. Since oxidation of the ferrocene moiety completely inhibited the Na+ transport, the redox-active centre provides a potential mechanism for controlling ion flux.
Hall
Adam C
AC
Department of Biological Sciences, Smith College, MA 01063, USA. ahall@smith.edu
Suarez
Cristina
C
Hom-Choudhury
Anindita
A
Manu
Aida N
AN
Hall
C Dennis
CD
Kirkovits
Gregory J
GJ
Ghiriviga
Ion
I
D002412:Cations; D004563:Electrochemistry / Q000379:methods; D005296:Ferrous Compounds / Q000737:chemistry*; D007473:Ion Channels / Q000138:chemical synthesis / Q000737:chemistry*; D017136:Ion Transport; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D000075163:Metallocenes; D010084:Oxidation-Reduction; D010714:Phosphatidylethanolamines / Q000737:chemistry; D012964:Sodium / Q000737:chemistry / Q000378:metabolism; D013050:Spectrometry, Fluorescence
D002412:Cations; D005296:Ferrous Compounds; D007473:Ion Channels; D008051:Lipid Bilayers; D000075163:Metallocenes; D010714:Phosphatidylethanolamines; D012964:Sodium; C004998:ferrocene