Impact of HLA-C on acute rejection in liver transplantation.
Although liver transplants show a special tolerogenic behaviour, rejection remains an important problem that involves several immunological mechanisms, some of which are unknown. Our study sought to analyze the influence of HLA-C polymorphism on short-term liver graft acceptance by HLA-C genotyping of 100 orthotopic liver transplant recipient-donor pairs. Recipients were statified according to the occurrence of acute rejection. HLA-Cw*06 allele appeared to be underrepresented among recipients without versus those with acute rejection or those in control groups. With regard to HLA-C allelic compatibility, the frequency of acute rejection or those in episodes decreased with fewer HLA-C mismatches. These findings suggest the participation of HLA-C molecules in liver graft alloresponses, involving HLA-C genotyping, as well as compatibility.
Moya-Quiles
M R
MR
Immunology Service, University Hospital Virgen de la Arrixaca, Murcia, Spain.
Torío
A
A
Muro
M
M
Montes-Ares
O
O
Marin
L
L
Minguela
A
A
Sánchez-Bueno
F
F
Garcia-Alonso
A M
AM
Parrilla
P
P
Alvarez-López
M R
MR
D000483:Alleles; D004359:Drug Therapy, Combination; D005838:Genotype; D006084:Graft Rejection / Q000453:epidemiology*; D015236:HLA-C Antigens / Q000097:blood / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007108:Immune Tolerance; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016031:Liver Transplantation / Q000276:immunology*; D012189:Retrospective Studies
D015236:HLA-C Antigens; D007166:Immunosuppressive Agents