title: Arginine-based molecular transporters: the synthesis and chemical evaluation of releasable taxol-transporter conjugates.
abstract: [structure: see text] A flexible and efficient procedure has been developed for the conjugation of taxol to various arginine-based molecular transporters via the taxol C2' O-chloroacetyl derivative. The resultant taxol-transporter conjugates are highly water soluble and release free taxol with half-lives of minutes to hours depending on the pH and the linker structure.
authors.affiliation: CellGate, Inc., 552 Del Rey Avenue, Sunnyvale, California 95085, USA. kirschberg@cellgateinc.com
authors.forename: Thorsten A
authors.initials: TA
authors.lastname: Kirschberg
authors.forename: Chris L
authors.initials: CL
authors.lastname: VanDeusen
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Rothbard
authors.forename: Michael
authors.initials: M
authors.lastname: Yang
authors.forename: Paul A
authors.initials: PA
authors.lastname: Wender
mesh_terms: D000107:Acetylation; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001120:Arginine / Q000031:analogs & derivatives*; D006207:Half-Life; D006863:Hydrogen-Ion Concentration; D026901:Membrane Transport Proteins / Q000138:chemical synthesis*; D015394:Molecular Structure; D017239:Paclitaxel / Q000737:chemistry*; D012995:Solubility; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D026901:Membrane Transport Proteins; D001120:Arginine; D017239:Paclitaxel