Expression of CD38 in human promyelocytic leukemia HL-60 cell line during differentiation by niacin-related compounds.
It was found that three niacin-related compounds, isonicotinic acid, nicotinamide, and nicotinamide N-oxide, induced granulocytic differentiation in HL-60 cells. We investigated the expression of CD38, which catalyzes the synthesis of cyclic ADP-ribose, a Ca2+ mobilizer, during differentiation by niacin-related compounds. It was found that CD38 was induced by isonicotinic acid, whereas nicotinamide and nicotinamide N-oxide containing an amino group did not induce it. The difference in expression of CD38 may provide some useful information for the elucidation of the mechanisms of cell differentiation.
Iwata
Keiko
K
Laboratory of Molecular and Cellular Biology, Department of Life Science, Faculty of Bioresources, Mie University, Tsu, Mie 514-8507, Japan.
Ogata
Shin
S
Okumura
Katsuzumi
K
Taguchi
Hiroshi
H
D036541:ADP-ribosyl Cyclase / Q000096:biosynthesis* / Q000378:metabolism; D051997:ADP-ribosyl Cyclase 1; D015703:Antigens, CD / Q000096:biosynthesis* / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D005434:Flow Cytometry; D015870:Gene Expression / Q000187:drug effects*; D018922:HL-60 Cells; D006801:Humans; D007539:Isonicotinic Acids / Q000494:pharmacology*; D008562:Membrane Glycoproteins; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D014212:Tretinoin / Q000378:metabolism / Q000494:pharmacology
D015703:Antigens, CD; D007539:Isonicotinic Acids; D008562:Membrane Glycoproteins; D009536:Niacinamide; D014212:Tretinoin; C037645:nicotinamide N-oxide; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1