Altered lymphocyte heat shock protein 70 expression in patients with HIV disease.
Heat shock protein (HSP) expression in lymphocytes isolated from 20 patients with HIV disease and 15 age-matched controls was determined. Fold increases in lymphocyte hsp70 expression after heat shock were 4.52 +/- 2.97 in HIV-positive individuals compared with 2.60 +/- 1.29 for HIV-negative controls (P= 0.001). Given clear roles for HSP in the cross-presentation of antigens, alpha-defensin internalization and pro-inflammatory cytokine production, a further investigation of HSP in HIV patients is merited.
Agnew
Linda L
LL
School of Biological, Biomedical and Molecular Sciences, University of New England, Armidale, NSW 2350, Australia.
Kelly
Mark
M
Howard
Jonathan
J
Jeganathan
Sarangapany
S
Batterham
Marijka
M
Ffrench
Rosemary A
RA
Gold
Julian
J
Watson
Kenneth
K
D000328:Adult; D015153:Blotting, Western; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000097:blood* / Q000276:immunology / Q000821:virology; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D019562:Viral Load
D018840:HSP70 Heat-Shock Proteins