title: The impact of combinatorial chemistry on drug discovery.
abstract: This review will firstly present recent examples in the fields of immobilized arrays and dynamic combinatorial chemistry. The article will then emphasize the impact of combinatorial chemistry on target-focused libraries, demonstrating the usefulness of matrix-formatting for structure-activity relationship analysis and/or the advancement in library design and evaluation.
authors.affiliation: Johnson & Johnson Pharmaceutical Research & Development, 3210 Merryfield Row, San Diego, CA 92121, USA.
authors.forename: Alice
authors.initials: A
authors.lastname: Lee
authors.forename: J Guy
authors.initials: JG
authors.lastname: Breitenbucher
mesh_terms: D000818:Animals; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis