Anti-relapse properties of IDN 5082, a standardized extract of Salvia miltiorrhiza, in alcohol-preferring rats.
Salvia miltiorrhiza extracts have been reported to suppress acquisition and maintenance of alcohol drinking behavior in Sardinian alcohol-preferring (sP) rats. The present study investigated whether IDN 5082, a standardized extract of Salvia miltiorrhiza, was capable of preventing, in sP rats, the development of the so-called alcohol deprivation effect (ADE), i.e. the transient increase in alcohol intake that occurs in laboratory animals after a period of alcohol deprivation. Interestingly, ADE has been proposed to model alcohol relapses in human alcoholics. The acute, intragastric administration of 25, 50, and 100 mg/kg IDN 5082 resulted in the complete suppression of the extra amount of alcohol consumed during the first hour of re-access to alcohol after 7 days of deprivation. These results suggest that IDN 5082 may possess anti-relapse properties.
Serra
Salvatore
S
Bernard B. Brodie Department of Neuroscience, University of Cagliari, Cagliari, Italy.
Vacca
Giovanni
G
Tumatis
Silvia
S
Carrucciu
Angela
A
Morazzoni
Paolo
P
Bombardelli
Ezio
E
Colombo
Giancarlo
G
Gessa
Gian Luigi
GL
Carai
Mauro A M
MA
D000428:Alcohol Drinking / Q000188:drug therapy* / Q000517:prevention & control; D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use*; D008297:Male; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D011919:Rats, Inbred Strains; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D055502:Secondary Prevention
D004365:Drugs, Chinese Herbal; C482607:IDN 5082