Rapamycin in lung transplantation: preliminary results.
BACKGROUND
Rapamycin is a potent immunosuppressive agent with a different mechanism of action and different adverse effects from those of calcineurin inhibitors (CNIs).


OBJECTIVE
To analyze our experience with rapamycin in patients undergoing lung transplantation and heart-lung transplantation in our center.


METHODS
Patients were treated with rapamycin when showing chronic rejection and/or toxicity associated with the CNI after lung transplantation or heartlung transplantation. Patients with chronic rejection were administered rapamycin in combination with CNIs, whereas the CNIs were eliminated in patients with toxicity.


RESULTS
Since October 2001, 7 patients (4 women), of mean age 45+/-15 years, received treatment with rapamycin (heart-lung transplantation, 2 cases; lung transplantation, 5 cases). The indications were chronic rejection in 4 patients and CMIs toxicity in 3 patients (kidney failure in 2 cases and optic neuropathy in 1 case). Pulmonary function stabilization was observed in 3 of 4 patients receiving rapamycin for chronic rejection. In the 3 patients with CNIs toxicity elimination of these drugs did not result in pulmonary functional deterioration. Patients with kidney failure showed an improvement in creatinine levels; visual acuity improved in the patient with optic neuropathy. We observed 2 infectious complications (pneumococcal pneumonia and pulmonary aspergillosis), which resolved with treatment.


CONCLUSIONS
Rapamycin is an alternative for lung-transplant recipients who develop chronic rejection and/or CNIs toxicity.
Ussetti
P
P
Lung and Cardiopulmonary Transplant Unit, Clínica Puerta de Hierro, Madrid, Spain. pied2152@separ.es
Laporta
R
R
de Pablo
A
A
Carreño
C
C
Segovia
J
J
Pulpón
L
L
D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016040:Lung Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D020123:Sirolimus / Q000627:therapeutic use*
D007166:Immunosuppressive Agents; D003404:Creatinine; D020123:Sirolimus