title: Efficient synthesis of B-alkylated oxazaborolidines derived from ephedrine and norephedrine.
abstract: [reaction: see text] Representative B-butyl- and B-methyl-1,3,2-oxazaborolidines derived from ephedrine and norephedrine were prepared in good yield and excellent purity by one-pot treatment of B-H oxazaborolidines with the corresponding organolithium reagent and subsequent hydrolysis of the cyclic borohydride intermediate with anhydrous ammonium chloride.
authors.affiliation: Department of Chemistry, University of Puerto Rico-Humacao, CUH Station, Humacao, Puerto Rico 00791, USA. mr_ortiz@webmail.uprh.edu
authors.forename: Margarita
authors.initials: M
authors.lastname: Ortiz-Marciales
authors.forename: Eduvigis
authors.initials: E
authors.lastname: González
authors.forename: Melvin
authors.initials: M
authors.lastname: De Jesús
authors.forename: Sandraliz
authors.initials: S
authors.lastname: Espinosa
authors.forename: Wildeliz
authors.initials: W
authors.lastname: Correa
authors.forename: Johanna
authors.initials: J
authors.lastname: Martínez
authors.forename: Ruth
authors.initials: R
authors.lastname: Figueroa
mesh_terms: D000478:Alkylation; D001894:Borohydrides / Q000737:chemistry; D001896:Boron Compounds / Q000138:chemical synthesis*; D004809:Ephedrine / Q000031:analogs & derivatives*; D018020:Lithium Compounds / Q000737:chemistry; D015394:Molecular Structure; D010078:Oxazines / Q000138:chemical synthesis*; D010665:Phenylpropanolamine / Q000031:analogs & derivatives*; D013237:Stereoisomerism
chemical_list: D001894:Borohydrides; D001896:Boron Compounds; D018020:Lithium Compounds; D010078:Oxazines; D010665:Phenylpropanolamine; D004809:Ephedrine