[The role of synaptic transmission in memory and neurodegeneration processes and effects of neurotropic preparations].
Academician Zakusov, in his book Pharmacology of Central Synapses (Moscow, 1973), emphasized the central role of synaptic processes in regulation of various forms of behavior, memory, and psychotropic drug action. The paper considers most promising directions in the search for substances possessing nootropic and neuroprotector properties, many of which were developed at the Institute of Pharmacology based on the notion about synaptic processes. These investigations led to the creation of well-known drugs such as mexidole, noopept, nooglutyl, beglimin, etc. Special attention is devoted to the implementation and modern development of the ideas of Academician Zakusov. Recent data are presented on the role of neuropeptides, neurotrophins, and intracellular signaling mechanisms in synaptic plasticity, memory processes, and development of neurodegenerative states.
Voronina
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Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
D000818:Animals; D006801:Humans; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D009410:Nerve Degeneration / Q000503:physiopathology*; D009473:Neuronal Plasticity / Q000502:physiology; D018697:Nootropic Agents / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000502:physiology*
D018697:Nootropic Agents
Rol' sinapticheskoĭ peredachi v protsessakh pamiati, neĭrodegeneratsii i mekhanizme deĭstviia neĭrotropnykh preparatov.