The development and regulation of gene repair.
A technique that can direct the repair of a genetic mutation in a human chromosome using the DNA repair machinery of the cell is under development. Although this approach is not as mature as other forms of gene therapy and fundamental problems continue to arise, it promises to be the ultimate therapy for many inherited disorders. There is a continuing effort to understand the potential and the limitations of this controversial approach.
Liu
Li
L
Department of Biological Sciences, University of Delaware, Newark, Delaware 19716, USA.
Parekh-Olmedo
Hetal
H
Kmiec
Eric B
EB
D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D018390:Gene Targeting; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000628:therapy; D015316:Genetic Therapy / Q000009:adverse effects / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D009154:Mutation; D010944:Plants / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics