title: Poly(butylcyanoacrylate) nanoparticles for topical delivery of 5-fluorouracil.
abstract: Poly(butylcyanoacrylate) nanoparticles (PBCN) as a drug carrier of 5-fluorouracil (5FU) intended for topical treatment of skin lesia were investigated. The presence of 5FU (as saline solution, pH 10-11) in the polymerization medium affected the polymerization as well as the nanoparticle formation by influencing the initiation of the polymerization reaction. 5FU acted as an initiator in the anionic polymerization of n-butylcyanoacrylate monomer through its nucleophilic nitrogen centers. The results obtained by GPC, 1H NMR, and X-ray diffraction allude to a possible mechanism of cytostatic immobilization in the polymer matrix, with evidence for both free and bound forms of the drug.
authors.affiliation: Laboratory of Amphiphilic and Nonionogenic Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 103A, 1113 Sofia, Bulgaria. msimeon@polymer.bas.bg
authors.forename: M
authors.initials: M
authors.lastname: Simeonova
authors.forename: R
authors.initials: R
authors.lastname: Velichkova
authors.forename: G
authors.initials: G
authors.lastname: Ivanova
authors.forename: V
authors.initials: V
authors.lastname: Enchev
authors.forename: I
authors.initials: I
authors.lastname: Abrahams
mesh_terms: D000287:Administration, Topical; D016503:Drug Delivery Systems / Q000379:methods*; D004659:Enbucrilate / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*; D005472:Fluorouracil / Q000008:administration & dosage / Q000032:analysis / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*
chemical_list: D004659:Enbucrilate; D005472:Fluorouracil