Inhibition of molar eruption and root elongation in MT1-MMP-deficient mice.
To study whether eruption of teeth and root growth require remodeling of collagen in the peridental tissues, we studied molar development in mice deficient in MT1-MMP, an enzyme essential for remodeling of soft tissue-hard tissue interfaces. The lower jaws of deficient mice and their wildtype littermates were subjected to stereologic analysis. It was shown that in deficient animals, eruption and root elongation were severely inhibited, signifying a role of the enzyme in these developmental processes.
Beertsen
W
W
Department of Periodontology, Academic Center for Dentistry Amsterdam, University of Amsterdam, The Netherlands. w.beertsen@acta.nl
Holmbeck
K
K
Niehof
A
A
Bianco
P
P
Chrysovergis
K
K
Birkedal-Hansen
H
H
Everts
V
V
D000818:Animals; D016723:Bone Remodeling / Q000502:physiology; D002113:Calcification, Physiologic / Q000502:physiology; D024022:Fibrillar Collagens / Q000378:metabolism; D053511:Matrix Metalloproteinase 14; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D008963:Molar / Q000201:enzymology / Q000254:growth & development; D010513:Periodontal Ligament / Q000166:cytology / Q000201:enzymology*; D014078:Tooth Eruption / Q000502:physiology*; D014092:Tooth Root / Q000166:cytology / Q000201:enzymology* / Q000254:growth & development
D024022:Fibrillar Collagens; C507096:Mmp14 protein, mouse; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases; D053511:Matrix Metalloproteinase 14