Expression of BEN, a member of TFII-I family of transcription factors, during mouse pre- and postimplantation development.
BEN is a member of the TFII-I family of transcription factors, characterized by the presence of multiple helix-loop-helix repeat domains. Our immunohistochemical analysis demonstrated broad and extensive expression of BEN during mouse pre- and postimplantation development, with highest levels occurring during early to midgestation. Maternally expressed BEN is present in both the cytoplasm and nuclei of the zygote; however, it retains a predominantly nuclear localization between the two-cell stage of development and early blastocyst stages. This nuclear expression is observed in most tissues throughout development. Although, it is interesting to note that at E4.5-6.5, during early gastrulation stage, BEN is localized in the cytoplasm. At later stages, BEN retains an extensive expression pattern in a variety of developing systems implicating its involvement in tissue development and organogenesis.
Bayarsaihan
Dashzeveg
D
Department of Molecular, Cellular and Developmental Biology, Yale University, 266 Whitney avenue, New Haven, CT 06520, USA. bayarsaihan@yale.edu
Bitchevaia
Natalia
N
Enkhmandakh
Badam
B
Tussie-Luna
Maria Isabel
MI
Leckman
James F
JF
Roy
Ananda
A
Ruddle
Frank
F
D020410:Activated-Leukocyte Cell Adhesion Molecule / Q000378:metabolism*; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D047108:Embryonic Development; D005260:Female; D018257:Helix-Loop-Helix Motifs; D007150:Immunohistochemistry; D051379:Mice / Q000196:embryology* / Q000378:metabolism*; D009928:Organ Specificity; D011247:Pregnancy; D019473:Transcription Factors, TFII / Q000378:metabolism
D020410:Activated-Leukocyte Cell Adhesion Molecule; D019473:Transcription Factors, TFII