title: Synthesis and PDF inhibitory activities of novel benzothiazolylidenehydroxamic acid derivatives.
abstract: A novel series of benzothiazolylidenehydroxamic acid derivatives has been designed and synthesized as PDF inhibitors. Some of this novel class of PDF inhibitors exhibited micromolar order enzyme inhibitory activity and antibacterial activity.
authors.affiliation: Research Laboratories, Senju Pharmaceutical Co., Ltd., 1-5-4 Murotani, Nishi-Ku, Kobe, Hyogo 651-2241, Japan. yingshe-cui@senju.co.jp
authors.forename: Wataru
authors.initials: W
authors.lastname: Takayama
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Shirasaki
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sakai
authors.forename: Emi
authors.initials: E
authors.lastname: Nakajima
authors.forename: Shuhei
authors.initials: S
authors.lastname: Fujita
authors.forename: Kanako
authors.initials: K
authors.lastname: Sakamoto-Mizutani
authors.forename: Jun
authors.initials: J
authors.lastname: Inoue
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D052160:Benzothiazoles; D001665:Binding Sites / Q000187:drug effects / Q000502:physiology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D052160:Benzothiazoles; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D013844:Thiazoles; D000581:Amidohydrolases; C084507:peptide deformylase; C005465:benzothiazole