title: Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?
abstract: Intra-myocellular triglycerides (IMTG) accumulate in the muscle of obese and endurance-trained (ET) humans and are considered a pathogenic factor in the development of insulin resistance, in the former. We postulate that this paradox may be associated with the peroxidation status of the IMTG. IMTG content was the same in the obese and ET subjects. The lipid peroxidation/IMTG ratio was 4.2-fold higher in the obese subjects. Hence, obesity results in an increased level of IMTG peroxidation while ET has a protective effect on IMTG peroxidation. This suggests a link between the lipid peroxidation/IMTG ratio and insulin resistance.
authors.affiliation: Clinique Romande de Réadaptation SUVA Care, Case postale 352, 1951 Sion, Switzerland. aaron.russell@crr-suva.ch
authors.forename: Aaron P
authors.initials: AP
authors.lastname: Russell
authors.forename: Giacomo
authors.initials: G
authors.lastname: Gastaldi
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Bobbioni-Harsch
authors.forename: Patrizia
authors.initials: P
authors.lastname: Arboit
authors.forename: Charles
authors.initials: C
authors.lastname: Gobelet
authors.forename: Olivier
authors.initials: O
authors.lastname: Dériaz
authors.forename: Alain
authors.initials: A
authors.lastname: Golay
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Witztum
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Giacobino
mesh_terms: D000328:Adult; D000447:Aldehydes / Q000032:analysis; D006801:Humans; D015227:Lipid Peroxidation; D008055:Lipids / Q000145:classification; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000737:chemistry / Q000166:cytology / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D010807:Physical Endurance; D014280:Triglycerides / Q000032:analysis / Q000378:metabolism*
chemical_list: D000447:Aldehydes; D008055:Lipids; D014280:Triglycerides; C027576:4-hydroxy-2-nonenal