[Modifying action of oxytocin on the biological properties of the causative agents of anaerobic non-clostridial infection].
In a number of in vitro experiments the effect of oxytocin on the antilysozyme and anticomplemental activity of Propiobacterium propionicum, Bacteroides fragilis, Prevotella melaninogenica and Peptostreprtococcus anaerobius, isolated from patients with acute pyoinflammatory pleuropulmonary diseases, was studied. Antibiotic resistance dynamics of the infective agents under study to lincomycin, clindamycin, thienam, vancomycin was also detected. The inhibiting activity of oxytocin on the persistence properties of B. fragilis, P. melanogenica and P. anaerobius was noted. Under the influence of the preparations used changes in the sensitivity of the strains to a number of antibiotics of the lincosamide, carbapenem and glycopeptide groups were found to occur. The data thus obtained were indicative of the possible mechanisms of action of oxytocin in the treatment of acute pyoinflammatory pleuropulmonary diseases of anaerobic nonclostridial etiology.
Abramzon
O M
OM
Institute of Cellular and Intracellular Symbiosis, Orenburg, Russia.
Kirillov
D A
DA
Pan'kov
A S
AS
Perunova
N B
NB
Elagina
N N
NN
Valyshev
A V
AV
Bukharin
O V
OV
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects* / Q000302:isolation & purification / Q000378:metabolism; D001439:Bacteroides / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism; D003169:Complement Inactivator Proteins / Q000378:metabolism; D004352:Drug Resistance, Microbial; D016724:Empyema, Pleural / Q000382:microbiology; D004791:Enzyme Inhibitors / Q000378:metabolism; D006801:Humans; D008826:Microbial Sensitivity Tests; D009113:Muramidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D010121:Oxytocin / Q000494:pharmacology*; D010462:Peptostreptococcus / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism; D011030:Pneumothorax / Q000382:microbiology; D018720:Prevotella / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism
D000900:Anti-Bacterial Agents; D003169:Complement Inactivator Proteins; D004791:Enzyme Inhibitors; D010121:Oxytocin; D009113:Muramidase
Modifitsiruiushchee deĭstvie oksitotsina na biologicheskie svoĭstva vozbuditeleĭ anaérobnoĭ neklostria'noĭ infektsii.