title: Thermo- and pH-responsive biodegradable poly(alpha-N-substituted gamma-glutamine)s.
abstract: New double stimuli-responsive poly(alpha-N-substituted gamma-glutamine) has been developed, which was synthesized by the reaction of poly(gamma-glutamic acid) with amino alcohols. Appropriate combinations of the amino alcohols provided the biodegradable poly(amino acid) exhibiting a sharp lower critical solution temperature (LCST) in water. Furthermore, the phase transition temperature was highly sensitive to pH changes.
authors.affiliation: Department of Materials Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Tachibana
authors.forename: Motoichi
authors.initials: M
authors.lastname: Kurisawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uyama
authors.forename: Shiro
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D000605:Amino Alcohols / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D010455:Peptides / Q000737:chemistry*; D044367:Phase Transition; D012995:Solubility; D013696:Temperature
chemical_list: D000605:Amino Alcohols; D001672:Biocompatible Materials; D010455:Peptides; C097188:polyglutamine