title: Proteomics in the postgenomic age.
abstract: Technical developments in the field of proteomics are poised to generate advances in our understanding of protein structure, function, and organization in complex signaling and regulatory networks. Improvements in mass spectrometry instrumentation, the implementation of protein arrays, and the development of robust informatics software are providing sensitive, high-throughput technologies for large-scale identification and quantitation of protein expression, protein modifications, subcellular localization, protein function, and protein-protein interactions. These advances have significant implications for understanding how cellular proteomes are regulated in health and disease.
authors.affiliation: Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington 98195, USA.
authors.forename: Richard S
authors.initials: RS
authors.lastname: Morrison
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Mark D
authors.initials: MD
authors.lastname: Johnson
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Conrads
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling / Q000379:methods; D016678:Genome; D006801:Humans; D020543:Proteome / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D040901:Proteomics
chemical_list: D020543:Proteome