title: Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition.
abstract: Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.
authors.affiliation: Faculty of Pharmacy, Faculty of Medicine, Laval University, Quebec, Canada G1K 7P4.
authors.forename: Laurence
authors.initials: L
authors.lastname: Covassin
authors.forename: Michel
authors.initials: M
authors.lastname: Desjardins
authors.forename: Denis
authors.initials: D
authors.lastname: Soulet
authors.forename: René
authors.initials: R
authors.lastname: Charest-Gaudreault
authors.forename: Marie
authors.initials: M
authors.lastname: Audette
authors.forename: Richard
authors.initials: R
authors.lastname: Poulin
mesh_terms: D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D019281:Dimerization; D011073:Polyamines / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011700:Putrescine / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D013095:Spermidine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014992:Xylenes / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology
chemical_list: D011073:Polyamines; D014992:Xylenes; D013095:Spermidine; D011700:Putrescine