title: Nuclear microenvironments support physiological control of gene expression.
abstract: There is growing recognition that the organization of nucleic acids and regulatory proteins is functionally linked to the assembly, localization and activity of gene regulatory machinery. Cellular, molecular, biochemical and in-vivo genetic evidence support an obligatory relationship between nuclear microenvironments where regulatory complexes reside and fidelity of transcriptional control. Perturbations in mechanisms governing the intranuclear trafficking of transcription factors and the temporal/spatial organization of regulatory proteins within the nucleus occur with compromised gene expression that abrogates skeletal development and mediates leukemogenesis.
authors.affiliation: Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, 55 Lake Ave. North, Worcester, MA 01655, USA. gary.stein@umassmed.edu
authors.forename: Gary S
authors.initials: GS
authors.lastname: Stein
authors.forename: Jane B
authors.initials: JB
authors.lastname: Lian
authors.forename: Martin
authors.initials: M
authors.lastname: Montecino
authors.forename: Janet L
authors.initials: JL
authors.lastname: Stein
authors.forename: André J
authors.initials: AJ
authors.lastname: van Wijnen
authors.forename: Amjad
authors.initials: A
authors.lastname: Javed
authors.forename: Jitesh
authors.initials: J
authors.lastname: Pratap
authors.forename: Je
authors.initials: J
authors.lastname: Choi
authors.forename: S Kaleem
authors.initials: SK
authors.lastname: Zaidi
authors.forename: Soraya
authors.initials: S
authors.lastname: Gutierrez
authors.forename: Kimberly
authors.initials: K
authors.lastname: Harrington
authors.forename: Jiali
authors.initials: J
authors.lastname: Shen
authors.forename: Daniel
authors.initials: D
authors.lastname: Young
authors.forename: Shirwin
authors.initials: S
authors.lastname: Pockwinse
mesh_terms: D002467:Cell Nucleus; D002843:Chromatin / Q000235:genetics; D005786:Gene Expression Regulation; D015530:Nuclear Matrix; D015675:Osteocalcin / Q000235:genetics / Q000378:metabolism; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D002843:Chromatin; D014157:Transcription Factors; D015675:Osteocalcin