MT1-mmp: a collagenase essential for tumor cell invasive growth.
The manuscript discussed in this preview describes that reconstituted three-dimensional extracellular matrices such as fibrillar collagen and fibrin exert stringent territorial growth control on cells. The authors show that tumor cells are able to escape the matrix-enforced growth control effect (entrapment) by pericellular proteolysis mediated by MT1-MMP, a membrane bound matrix metalloproteinase capable of directly cleaving both type I collagen and fibrin but not by other, soluble matrix metalloprotinases. These data convincingly demonstrate one way that tumor cells orchestrate proteolysis to invade surrounding tissues.
Holmbeck
Kenn
K
Matrix Metalloproteinase Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.
Bianco
Paolo
P
Birkedal-Hansen
Henning
H
D000818:Animals; D002455:Cell Division; D024042:Collagen Type I / Q000378:metabolism; D005337:Fibrin / Q000378:metabolism; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology*
D024042:Collagen Type I; D005337:Fibrin; D053504:Matrix Metalloproteinases, Membrane-Associated; D008666:Metalloendopeptidases