[Derivatives of 2-mercaptobenzenesulphonylamide. IV. Synthesis and properties of some hypoglycemic agents derived from N-(4-chloro-2-mercapto-5-methylbenzenesulphonyl)urea].
Some new S- and N'-substituted derivatives of N-(4-chloro-2-mercapto-5-methylbenzenesulphonyl)urea were obtained. Their structures were confirmed by elemental analysis, and by IR and NMR spectra. Schemes of the reactions, their yields and some physico-chemical and pharmacological properties of the compounds are also given. N-(4-chloro-5-methyl-2-methylthiobenzenesulphonyl)-N'-R-ureas (I, II, IV) were screened for hypoglycemic activity in rats, and the results are compared to effect of tolbutamide.
Brzozowski
Z
Z
Katedra i Zakład Technologii Chemicznej Srodków Leczniczych Akademii Medycznej w Gdańsku, ul. K. Marksa 107, 80-416 Gdańsk.
Wójcikowski
C
C
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013453:Sulfonylurea Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; C479063:N-(4-chloro-2-mercapto-5-methylbenzenesulphonyl)urea; D013453:Sulfonylurea Compounds
Pochodne 2-merkaptobenzenosulfonamidu. IV. Syntezy i właściwości hipoglikemizujace niektórych pochodnych N-(4-chloro-2-merkapto-5-metylobenzenosulfonylo)mocznika.