Detection of 1270 nm emission from singlet oxygen and photocytotoxic property of sugar-pendant 60 fullerenes.
Sugar-pendant [60] fullerene derivatives have been prepared from carbohydrate-linked azides 1a-e. Both monosugar (4a-e) and bissugar derivatives (5a-e) produce singlet oxygen ((1)O(2)) under laser irradiation (355 nm) proved by the direct observation of (1)O(2) emission at 1270 nm. Monosugar derivatives exhibit photocytotoxicity varying by the attached sugar molecule.
Mikata
Yuji
Y
KYOUSEI Science Center, Nara Women's University, 630-8506 Nara, Japan. mikata@cc. nara-wu.ac.jp
Takagi
Satowa
S
Tanahashi
Maki
M
Ishii
Sayoko
S
Obata
Makoto
M
Miyamoto
Yuichi
Y
Wakita
Kazuhito
K
Nishisaka
Tsuyoshi
T
Hirano
Toru
T
Ito
Toshiaki
T
Hoshino
Mikio
M
Ohtsuki
Chikara
C
Tanihara
Masao
M
Yano
Shigenobu
S
D037741:Fullerenes / Q000032:analysis* / Q000737:chemistry / Q000633:toxicity*; D006367:HeLa Cells; D006801:Humans; D007834:Lasers; D017319:Photosensitizing Agents / Q000032:analysis* / Q000737:chemistry; D026082:Singlet Oxygen / Q000032:analysis* / Q000737:chemistry; D013055:Spectrophotometry, Infrared / Q000379:methods
D037741:Fullerenes; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; C069837:fullerene C60