Lack of carcinogenic risk in the prostate with transplacental and lactational exposure to bisphenol A in rats.
The current study was designed to examine the modulating effects of bisphenol A (BPA) on prostate cancer risk in male offspring exposed transplacentally and lactationally. BPA was administered to F344 female rats by gavage at 0, 0.05, 7.5, 30, 120 mg/kg/day during pregnancy and lactation periods. When F1 males reached 5 weeks old, they were given 10 subcutaneous injections of 3,2'-dimethyl-4-aminobiphenyl (DMAB) or corn oil vehicle and rats were then sacrificed under ether anesthesia at week 60. There were no observable effects on the accessory sex organ weights of male offspring. Transplacental and lactational exposure to BPA did not affect the incidences of preneoplastic and neoplastic lesions in the accessory sex organs (prostate and seminal vesicle) of F1 rats and did not induce any proliferating lesions without DMAB. Our data suggest that maternal exposure to BPA during the period of pregnancy and lactation does not affect the risk of prostate carcinogenesis in male offspring.
Ichihara
Toshio
T
Daiyu-kai Institute of Medical Science, 64 Goura, Nishiazai, Azai-cho, Ichinomiya 491-0113, Japan.
Yoshino
Hiroko
H
Imai
Norio
N
Tsutsumi
Tomoko
T
Kawabe
Mayumi
M
Tamano
Seiko
S
Inaguma
Shingo
S
Suzuki
Shugo
S
Shirai
Tomoyuki
T
D000284:Administration, Oral; D000611:Aminobiphenyl Compounds / Q000633:toxicity; D000818:Animals; D001559:Benzhydryl Compounds; D001835:Body Weight / Q000187:drug effects; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004968:Estrogens, Non-Steroidal / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D007774:Lactation; D008297:Male; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange; D010636:Phenols / Q000008:administration & dosage / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011467:Prostate / Q000187:drug effects* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D011916:Rats, Inbred F344; D012669:Seminal Vesicles / Q000187:drug effects / Q000473:pathology; D000098826:Bisphenol A Compounds
D000611:Aminobiphenyl Compounds; D001559:Benzhydryl Compounds; D002273:Carcinogens; D004968:Estrogens, Non-Steroidal; D010636:Phenols; C001042:2',3-dimethyl-4-aminobiphenyl; C006780:bisphenol A; D000098826:Bisphenol A Compounds