Prediction of adverse outcome associated with vaginal misoprostol for labor induction.
OBJECTIVE
To identify predictors of adverse outcome in pregnant women at term receiving 50 microg of intravaginal misoprostol for labor induction.


METHODS
A prospective observational study was conducted of 720 pregnant women at term with an unfavorable cervix and a medical or obstetric indication for labor induction. All patients received 50 microg of intravaginal misoprostol every 4h up to three doses. The primary outcome measure was "adverse outcome" defined as: neonatal death, fetal acidemia and emergent cesarean delivery performed for non-reassuring fetal heart rate tracings. A stepwise logistic regression analysis was used to identify predictors of adverse outcome.


RESULTS
Tachysystole (frequent uterine contractions) (odds ratio (OR), 3.7; 95% confidence interval (CI), 1.2-10.8) and fetal tachycardia (OR, 4.8; 95% CI, 1.4-16.2) were determined as significant predictors of adverse outcome. The specificity of the model was 94.2%, whereas the sensitivity was 20.4%.


CONCLUSIONS
In the absence of tachysystole and fetal tachycardia, an uneventful delivery might be expected for women receiving 50 microg of intravaginal misoprostol.
Mutlu Meydanli
M
M
SSK Maternity and Women's Health Teaching Hospital, Ankara, Turkey. mmmeydanli@superonline.com
Caliskan
Eray
E
Haberal
Ali
A
D000282:Administration, Intravaginal; D000293:Adolescent; D000328:Adult; D002585:Cesarean Section; D005260:Female; D005312:Fetal Blood; D005315:Fetal Diseases / Q000453:epidemiology; D005865:Gestational Age; D006340:Heart Rate, Fetal; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007226:Infant Mortality; D007231:Infant, Newborn; D007751:Labor, Induced / Q000379:methods*; D016015:Logistic Models; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects*; D011247:Pregnancy; D011446:Prospective Studies; D013610:Tachycardia / Q000453:epidemiology; D014590:Uterine Contraction
D016595:Misoprostol