title: Hochu-ekki-to suppresses development of dermatitis and elevation of serum IgE level in NC/Nga mice.
abstract: The Japanese herbal medicine Hochu-ekki-to (Chinese name: Bu-Zhong-Yi-Qi-tang) is composed of ten species of medical plants and is used for many therapeutic purposes such as recovery from weakness, dysfunction of the digestive system and fatigue. In certain groups of patients with intractable atopic dermatitis this prescription has shown clinical effectiveness. We examined the ability of Hochu-ekki-to to inhibit dermatitis and IgE production in atopic NC/Nga mice. Oral administration of Hochu-ekki-to suppressed spontaneous dermatitis and serum IgE levels in NC/Nga mice. This finding provides evidence that Hochu-ekki-to may have immunological effects in atopic dermatitis.
authors.affiliation: Department of Dermatology, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan. hiromik@med.osaka-cu.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: N
authors.initials: N
authors.lastname: Mizuno
authors.forename: H
authors.initials: H
authors.lastname: Kutsuna
authors.forename: H
authors.initials: H
authors.lastname: Teramae
authors.forename: S
authors.initials: S
authors.lastname: Ueoku
authors.forename: J
authors.initials: J
authors.lastname: Onoyama
authors.forename: K
authors.initials: K
authors.lastname: Yamanaka
authors.forename: N
authors.initials: N
authors.lastname: Fujita
authors.forename: M
authors.initials: M
authors.lastname: Ishii
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000097:blood*; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy
chemical_list: D004365:Drugs, Chinese Herbal; C402943:bu-zhong-yi-qi-tang; D007073:Immunoglobulin E