title: Peptide inhibitors of plasmin.
abstract: Seven peptides of the general formula A-Phe-Lys-X or A-Phe-NH-(CH2)5-NH2 where A = Glp or Ala, X = -OH, -NHC7H15 or -OC7H15 were obtained. The peptide H-Ala-Phe-Lys-NHC7H15 markedly inhibits the fibrinolytic activity of plasmin. The antifibrinolytic activity of the peptide Glp-Phe-Lys-OC7H15 is similar to EACA. The both peptides only slightly activate the caseinolytic activity of plasmin.
authors.affiliation: Institute of Chemistry, Branch of Warsaw University, Białystok.
authors.forename: K
authors.initials: K
authors.lastname: Midura-Nowaczek
authors.forename: I
authors.initials: I
authors.lastname: Bruzgo
authors.forename: W
authors.initials: W
authors.lastname: Roszkowska-Jakimiec
authors.forename: K
authors.initials: K
authors.lastname: Worowski
mesh_terms: D002364:Caseins / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D005341:Fibrinolysin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006868:Hydrolysis; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D002364:Caseins; D005343:Fibrinolytic Agents; D010455:Peptides; D005341:Fibrinolysin