Dexamethasone-induced exophthalmos in a group of Holstein calves.
Six Holstein calves were evaluated for progressive exophthalmos. The affected calves were receiving daily injections of dexamethasone (30 microg/kg subcutaneously twice daily) as part of a metabolic study. The control calves did not exhibit exophthalmos. The ocular examinations were normal except for the exophthalmos, which ranged from mild to marked in severity. Upon postmortem examination, marked deposition of retrobulbar adipose tissue was noted in the affected calves. Dexamethasone administration appears to increase deposition of retrobulbar adipose tissue resulting in a progressive exophthalmos.
Townsend
Wendy M
WM
Purdue University School of Veterinary Medicine, West Lafayette, IN 47907, USA. wlt@vet-purdue.edu
Renninger
Matthew
M
Stiles
Jean
J
Townsend
Jonathan R
JR
Krohne
Sheryl G
SG
D000818:Animals; D000831:Animals, Newborn; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced* / Q000473:pathology; D003907:Dexamethasone / Q000009:adverse effects*; D005094:Exophthalmos / Q000139:chemically induced / Q000662:veterinary*; D007279:Injections, Subcutaneous / Q000662:veterinary; D008297:Male; D012720:Severity of Illness Index
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone