title: Psychiatric adverse events during levetiracetam therapy.
abstract: The prevalence and psychopathologic features of psychiatric adverse events (PAE) in 517 patients taking levetiracetam (LEV) were investigated. Fifty-three (10.1%) patients developed PAE. A significant association was found with previous psychiatric history, history of febrile convulsions, and history of status epilepticus, whereas lamotrigine co-therapy had a protective effect. PAE were not related to the titration schedule of LEV, and certain patients seem to be biologically more vulnerable.
authors.affiliation: Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, UK.
authors.forename: M
authors.initials: M
authors.lastname: Mula
authors.forename: M R
authors.initials: MR
authors.lastname: Trimble
authors.forename: A
authors.initials: A
authors.lastname: Yuen
authors.forename: R S N
authors.initials: RS
authors.lastname: Liu
authors.forename: J W A S
authors.initials: JW
authors.lastname: Sander
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D000077287:Levetiracetam; D008297:Male; D010889:Piracetam / Q000009:adverse effects* / Q000031:analogs & derivatives*; D015995:Prevalence; D011605:Psychoses, Substance-Induced / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology*; D012307:Risk Factors
chemical_list: D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam