Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition.
Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.
Covassin
Laurence
L
Faculty of Pharmacy, Faculty of Medicine, Laval University, Quebec, Canada G1K 7P4.
Desjardins
Michel
M
Soulet
Denis
D
Charest-Gaudreault
René
R
Audette
Marie
M
Poulin
Richard
R
D001692:Biological Transport / Q000187:drug effects / Q000502:physiology; D019281:Dimerization; D011073:Polyamines / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011700:Putrescine / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D013095:Spermidine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014992:Xylenes / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology
D011073:Polyamines; D014992:Xylenes; D013095:Spermidine; D011700:Putrescine