Protective effects of glycyrrhizin on gentamicin-induced acute renal failure in rats.
The aim of this study was to investigate the effects of glycyrrhizin (200 mg/kg/day) on renal function in association with the regulation of aquaporin 2 water channel in rats with gentamicin (100 mg/kg/day)-induced acute renal failure. Polyuria in rats with gentamicin-induced acute renal failure was associated with down-regulation of renal aquaporin 2 in the inner and outer renal medulla, and cortex. Glycyrrhizin administration restored the expression of aquaporin 2 with paralleled changes in urine output. Changes in renal functional parameters, such as creatinine clearance, urinary osmolality, and solute-free reabsorption, accompanying acute renal failure were also partially restored after administration of glycyrrhizin. Histological changes in rats with gentamicin-induced acute renal failure were also abrogated by glycyrrhizin treatment. The above results suggest that glycyrrhizin treatment could ameliorate renal defects in rats with acute renal failure induced by gentamicin.
Sohn
Eun-Jin
EJ
Professional Graduate School of Oriental Medicine and Medicinal Resources Research Center, Wonkwang University, Iksan, Jeonbuk, 570-749, Republic of Korea.
Kang
Dae-Gill
DG
Lee
Ho-Sub
HS
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000517:prevention & control*; D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins / Q000096:biosynthesis; D015153:Blotting, Western; D015536:Down-Regulation; D005839:Gentamicins / Q000009:adverse effects*; D019695:Glycyrrhizic Acid / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D008517:Phytotherapy; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley
D000900:Anti-Bacterial Agents; C496025:Aqp2 protein, rat; D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins; D005839:Gentamicins; D020011:Protective Agents; D019695:Glycyrrhizic Acid