title: The significance of unstable chromosomes in colorectal cancer.
abstract: A very large fraction of cancers have an abnormal genetic content, called aneuploidy, which is characterized by changes in chromosome structure and number. One explanation for this aneuploidy is chromosomal instability, in which cancer cells gain or lose whole chromosomes or large fractions of chromosomes at a greatly increased rate compared with normal cells. Here, we explore experimental and theoretical evidence for the initiation of chromosomal instability in very early colorectal cancers, and reflect on the role that chromosomal instability could have in colorectal tumorigenesis.
authors.affiliation: Sidney Kimmel Comprehensive Cancer Center and Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
authors.forename: Harith
authors.initials: H
authors.lastname: Rajagopalan
authors.forename: Martin A
authors.initials: MA
authors.lastname: Nowak
authors.forename: Bert
authors.initials: B
authors.lastname: Vogelstein
authors.forename: Christoph
authors.initials: C
authors.lastname: Lengauer
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002869:Chromosome Aberrations; D015179:Colorectal Neoplasms / Q000235:genetics*; D006801:Humans