title: [Studies on the formation mechanism of alginate-chitosan microcapsule and its drug-loading and release properties on macromolecular drug].
abstract: OBJECTIVE
  To investigate the formation mechanism, macromolecular drug loading capacity and release property of alginate-chitosan microcapsules (ACM).
  
  
  METHODS
  ACM was prepared by emulsification-gelation method and its formation mechanism was studied by DSC analysis. Using bovine serum albumin (BSA) as model drug, the drug loading and release properties of the microcapsules on macromolecular drug were investigated.
  
  
  RESULTS
  The results of DSC analysis showed that there is electrostatic interaction between materials encapsulated in the microcapsule. With the increase of BSA microcapsule ratio, the BSA loading percentage rose from 9.20% to 35.08%; and with the ascent of chitosan (CTS) concentration, the BSA loading percentage increased from 30.29% to 38.12%. The BSA microcapsules whowed a two-phase release in both 0.1 mol.L-1 HCl and phosphate buffer saline (pH 7.4). With the increase of CTS concentration, the BSA release more and more slowly in 0.1 mol.L-1 HCl.
  
  
  CONCLUSIONS
  Spheric and well-dispersed alginate-chitosan microcapsules were prepared. The microcapsule showed good loading capacity to BSA as well as sustained release to a certain degree.
authors.affiliation: Department of Physical Pharmacy, School of Pharmacy, Peking University, Beijing 100083, China.
authors.forename: Sha
authors.initials: S
authors.lastname: Li
authors.forename: Xin-pu
authors.initials: XP
authors.lastname: Hou
mesh_terms: D000464:Alginates / Q000737:chemistry*; D001704:Biopolymers; D002152:Calorimetry, Differential Scanning; D002214:Capsules; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry*; D048271:Chitosan; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016503:Drug Delivery Systems; D012710:Serum Albumin, Bovine / Q000008:administration & dosage*; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D000464:Alginates; D001704:Biopolymers; D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D002686:Chitin; D012710:Serum Albumin, Bovine; D048271:Chitosan