title: ADAM33 is not associated with asthma in Puerto Rican or Mexican populations.
abstract: A recent study identified the ADAM33 gene as a promising candidate contributing to asthma. In Puerto Rican and Mexican populations, we have genotyped six single nucleotide polymorphisms (SNPs) that were used in the Genetics of Asthma in Latino Americans Study. We chose to study these two populations because in the United States, Puerto Ricans have the highest asthma prevalence, morbidity, and mortality and Mexicans the lowest. We used the transmission disequilibrium test to analyze associations between the ADAM33 gene variants and asthma, asthma severity, bronchodilator responsiveness, and total IgE levels using single SNPs, two to six SNP combinations, and specific haplotypes in 583 trios (proband with asthma and both biological parents). We also genotyped matched control samples to allow case-control analyses. None of the transmission disequilibrium test or case-control results showed significant association in either population. We found no evidence for association of single SNPs with asthma severity, bronchodilator response, or IgE levels in Mexicans or in the combined population. Two SNPs showed a modest association in Puerto Ricans, insignificant when the number of comparisons was taken into account. We conclude that the ADAM33 gene is not an important risk factor for asthma or for asthma-associated phenotypes in Mexicans or in Puerto Ricans.
authors.affiliation: University of California at San Francisco, San Francisco, CA 94143-0833, USA.
authors.forename: Denise L
authors.initials: DL
authors.lastname: Lind
authors.forename: Shweta
authors.initials: S
authors.lastname: Choudhry
authors.forename: Ngim
authors.initials: N
authors.lastname: Ung
authors.forename: Elad
authors.initials: E
authors.lastname: Ziv
authors.forename: Pedro C
authors.initials: PC
authors.lastname: Avila
authors.forename: Keyan
authors.initials: K
authors.lastname: Salari
authors.forename: Connie
authors.initials: C
authors.lastname: Ha
authors.forename: Elizabeth G
authors.initials: EG
authors.lastname: Lovins
authors.forename: Natasha E
authors.initials: NE
authors.lastname: Coyle
authors.forename: Sylvette
authors.initials: S
authors.lastname: Nazario
authors.forename: Jesus
authors.initials: J
authors.lastname: Casal
authors.forename: Alfonso
authors.initials: A
authors.lastname: Torres
authors.forename: Jose R
authors.initials: JR
authors.lastname: Rodriguez-Santana
authors.forename: Henry
authors.initials: H
authors.lastname: Matallana
authors.forename: Craig M
authors.initials: CM
authors.lastname: Lilly
authors.forename: Jorge
authors.initials: J
authors.lastname: Salas
authors.forename: Moises
authors.initials: M
authors.lastname: Selman
authors.forename: Homer A
authors.initials: HA
authors.lastname: Boushey
authors.forename: Scott T
authors.initials: ST
authors.lastname: Weiss
authors.forename: Rocio
authors.initials: R
authors.lastname: Chapela
authors.forename: Jean G
authors.initials: JG
authors.lastname: Ford
authors.forename: William
authors.initials: W
authors.lastname: Rodriguez-Cintron
authors.forename: Edwin K
authors.initials: EK
authors.lastname: Silverman
authors.forename: Dean
authors.initials: D
authors.lastname: Sheppard
authors.forename: Pui-Yan
authors.initials: PY
authors.lastname: Kwok
authors.forename: Esteban
authors.initials: E
authors.lastname: González Burchard
mesh_terms: D051722:ADAM Proteins; D000293:Adolescent; D001249:Asthma / Q000097:blood / Q000188:drug therapy / Q000235:genetics*; D001993:Bronchodilator Agents / Q000008:administration & dosage; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005838:Genotype; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D008666:Metalloendopeptidases / Q000235:genetics*; D017058:Mexican Americans / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012720:Severity of Illness Index
chemical_list: D001993:Bronchodilator Agents; D007073:Immunoglobulin E; D051722:ADAM Proteins; C450441:ADAM33 protein, human; D008666:Metalloendopeptidases