Brain lipid hydroperoxide level increases in senescence-accelerated mice at an early age.
We previously reported that the levels of lipid hydroperoxides, one of oxidative stress markers, in the brain and peripheral organs such as liver, heart, and lung are significantly higher in senescence accelerated-prone 8 mice (SAMP8) than in their controls, senescence accelerated-resistant mice (SAMR1), at 3, 6, and/or 9 months of age. To ascertain the exact age at which the lipid hydroperoxide levels increase in SAMP8, we measured them in the brain and liver of SAMP8 and SAMR1 at both 1 and 2 months of age. At 1 month of age, there was no significant inter-strain difference in the levels in brain or liver. However, in SAMP8 both levels were significantly greater at 2 months of age than at 1 month of age, but no such difference was detected for SAMR1. The present results suggest that SAMP8 are exposed to elevated levels of oxidative stress from an early age (2 months old), and that this may be a cause of the senescence-related impairments and degeneration in the brain and peripheral tissues (such as liver, heart, and lung) seen in this strain.
Yasui
Fumihiko
F
Division of Biotechnology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Kofu 400-8511, Japan.
Ishibashi
Masaru
M
Matsugo
Seiichi
S
Kojo
Shosuke
S
Oomura
Yutaka
Y
Sasaki
Kazuo
K
D000375:Aging / Q000378:metabolism*; D019588:Aging, Premature / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D008054:Lipid Peroxides / Q000032:analysis / Q000378:metabolism*; D008099:Liver / Q000737:chemistry; D008168:Lung / Q000737:chemistry; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013997:Time Factors
D008054:Lipid Peroxides