Drug-induced aminotransferase alterations during antiretroviral HIV post-exposure prophylaxis.
In 655 individuals receiving HIV postexposure prophylaxis (PEP), drug-induced aminotransferase alterations were frequent and severe in the nevirapine-including regimen, rare and mild-to-moderate in other combinations, and always reversible. Grade 3-4 incidence in protease inhibitor or nevirapine PEP was 0.5 and 25.0 per 100 person-months, respectively. Apart from nevirapine, continuing PEP appears to be safe even in the case of aminotransferase alterations. The usefulness of routine monitoring of liver function during PEP could be re-considered.
Puro
Vincenzo
V
Dipartimento di Epidemiologia, Istituto Nazionale per le Malattie Infettive, Lazzaro Spallanzani IRCCS, Rome, Italy.
Soldani
Fabio
F
De Carli
Gabriella
G
Lazarevic
Zlatan
Z
Mattioli
Francesca
F
Ippolito
Giuseppe
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000517:prevention & control*; D006801:Humans; D017758:Infectious Disease Transmission, Patient-to-Professional / Q000517:prevention & control; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D000637:Transaminases / Q000097:blood / Q000187:drug effects*
D019380:Anti-HIV Agents; D000637:Transaminases