The gene that encodes the herpes simplex virus type 1 latency-associated transcript influences the accumulation of transcripts (Bcl-x(L) and Bcl-x(S)) that encode apoptotic regulatory proteins.
The herpes simplex virus type 1 latency-associated transcript (LAT) inhibits apoptosis. We demonstrate here that LAT influences the accumulation of the Bcl-x(L) transcript versus the Bcl-x(S) transcript in Neuro-2A cells. Bcl-x(L) encodes an antiapoptotic protein, whereas Bcl-x(S) encodes a proapoptotic protein. Promoting the accumulation of Bcl-x(L) in neurons may inhibit apoptosis, thus enhancing the latency-reactivation cycle.
Peng
Weiping
W
Department of Veterinary and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska 68583-0905, USA.
Henderson
Gail
G
Perng
Guey-Chuen
GC
Nesburn
Anthony B
AB
Wechsler
Steven L
SL
Jones
Clinton
C
D017209:Apoptosis; D018259:Herpesvirus 1, Human / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000235:genetics*; D017735:Virus Latency; D051020:bcl-X Protein
C494811:BCL2L1 protein, human; D035683:MicroRNAs; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger; D014764:Viral Proteins; D051020:bcl-X Protein; C477253:latency associated transcript, herpes simplex virus-1