Analysis of field and laboratory data to derive selenium toxicity thresholds for birds.
In this paper, we critically evaluate the statistical approaches and datasets previously used to derive chronic egg selenium thresholds for mallard ducks (laboratory data) and black-necked stilts (field data). These effect concentration thresholds of 3%, 10% (EC10), or 20% have been used by regulatory agencies to set avian protection criteria and site remediation goals, thus the need for careful assessment of the data. The present review indicates that the stilt field dataset used to establish a frequently cited chronic avian egg selenium threshold of 6 mg/kg dry weight lacks statistical robustness (r2 = 0.19-0.28 based on generalized linear models), suggesting that stilt embryo sensitivity to selenium is highly variable or that factors other than selenium are principally responsible for the increase in effects observed at the lower range of this dataset. Hockey stick regressions used with the stilt field dataset improve the statistical relationship (r2 = 0.90-0.97) but result in considerably higher egg selenium thresholds (EC10 = 21-31 mg/kg dry wt). Laboratory-derived (for mallards) and field-derived (for stilts) teratogenicity EC10 values are quite similar (16-24 mg/kg dry wt). Laboratory data regarding mallard egg inviability and duckling mortality data provide the most sensitive and statistically robust chronic threshold (EC10) with logit, probit, and hockey stick regressions fitted to laboratory data, resulting in mean egg selenium EC10 values of 12 to 15 mg/kg dry weight (r2 = 0.75-0.90).
Adams
William J
WJ
Kennecott Utah Copper Corporation, 8315 West 3595 South, P.O. Box 6001, Magna, Utah 84044, USA. william.adams@riotinto.com
Brix
Kevin V
KV
Edwards
Melanie
M
Tear
Lucinda M
LM
DeForest
David K
DK
Fairbrother
Anne
A
D000818:Animals; D000831:Animals, Newborn; D001717:Birds; D016208:Databases, Factual; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000633:toxicity*; D007928:Lethal Dose 50; D010063:Ovum; D012016:Reference Values; D012044:Regression Analysis; D012643:Selenium / Q000633:toxicity*; D013723:Teratogens / Q000633:toxicity
D004785:Environmental Pollutants; D013723:Teratogens; D012643:Selenium