Novel acyclic deoxystreptamine mimetics targeting the ribosomal decoding site.
Vourloumis
Dionisios
D
Department of Medicinal Chemistry, Anadys Pharmaceuticals Inc., 9050 Camino Santa Fe, San Diego, CA 92121, USA. dvourloumis@anadyspharma.com
Winters
Geoffrey C
GC
Takahashi
Masayuki
M
Simonsen
Klaus B
KB
Ayida
Benjamin K
BK
Shandrick
Sarah
S
Zhao
Qiang
Q
Hermann
Thomas
T
D000617:Aminoglycosides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D001665:Binding Sites; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism; D006595:Hexosamines / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D012329:RNA, Bacterial / Q000378:metabolism*; D012335:RNA, Ribosomal / Q000378:metabolism*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D006595:Hexosamines; D012329:RNA, Bacterial; D012335:RNA, Ribosomal; C007265:2-deoxystreptamine