Factor V Leiden: a review of the literature.
Factor V Leiden, formed by a genetic mutation, disrupts the body's anticoagulation defense system. It was isolated as recently as 1994 as a risk factor for venous thromboembolism. Factor V Leiden has also been linked to preeclampsia, pregnancy loss, and fetal growth restriction. In addition, factor V Leiden has implications for women who are not pregnant. The most effective screening tool is a thorough personal and family history related to thrombosis. For women with a positive factor V Leiden screen, counseling regarding the risks of thrombosis is essential.
Ament
Lynette
L
Nurse-Midwifery Specialty, Yale University School of Nursing, New Haven, Conn. 06536, USA. lynette.ament@yale.edu
D000026:Abortion, Habitual / Q000209:etiology; D005165:Factor V / Q000235:genetics*; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D006801:Humans; D015404:Nursing Methodology Research; D017354:Point Mutation / Q000235:genetics; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000451:nursing*; D012307:Risk Factors; D013923:Thromboembolism / Q000235:genetics* / Q000451:nursing; D020246:Venous Thrombosis / Q000235:genetics* / Q000451:nursing
C095381:factor V Leiden; D005165:Factor V