title: Catalytic, three-component assembly reaction for the synthesis of pyrrolidines.
abstract: [reaction: see text] Copper(I) salts catalyze the three-component assembly reaction between an alpha-diazo ester, an imine, and various alkenes and alkynes to form substituted pyrrolidines with excellent to good diastereoselectivities in high yields. The transition metal-catalyzed decomposition of the alpha-diazo compound in the presence of the imine likely generates a transient azomethine ylid that undergoes addition with various dipolarophiles in a highly convergent manner.
authors.affiliation: Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA.
authors.forename: Chris V
authors.initials: CV
authors.lastname: Galliford
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Beenen
authors.forename: SonBinh T
authors.initials: ST
authors.lastname: Nguyen
authors.forename: Karl A
authors.initials: KA
authors.lastname: Scheidt