Transport of trace elements in lenses of normal and hereditary cataract UPL rats.
The multitracer technique was applied to the determination of the uptake of trace elements in the lenses of normal and hereditary cataract UPL rats to investigate the transport mechanisms of trace elements during cataract development. Be, Na, Sc, V, Cr, Mn, Fe, Co, Zn, As, Se, Rb, Sr, Y, Zr, Tc, Ru and Rh accumulate in normal and UPL cataract rat lenses. The rates of uptake of trace elements differ among species and also differ between normal and UPL rat lenses. The uptakes of V and Sr are greater in normal rat lenses, while the uptakes of Mn and Co are greater in UPL rat lenses. High concentrations of Zn are transported into normal rat lenses in comparison with other elements. However, the uptake of Se was highest in the lenses of UPL cataract rats. In addition, the difference in Se uptake between the normal and UPL rat lenses was greatest among the tested trace elements. The present study suggests that the transport characteristics of trace elements are different in the lenses of normal and UPL cataract rats. The different transport characteristics of trace elements in the lenses of normal and UPL cataract rats, especially the higher accumulation of Se in UPL rat lenses, may be implicated in cataract development.
Nabekura
Tomohiro
T
Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Kamishin'ei-cho, Niigata, 950-2081, Japan. nabe@niigata-pharm.ac.jp
Minami
Takeshi
T
Hirunuma
Rieko
R
Enomoto
Shuichi
S
Tomohiro
Masayuki
M
Ito
Yoshimasa
Y
Kitagawa
Shuji
S
D000818:Animals; D001692:Biological Transport; D002386:Cataract / Q000378:metabolism*; D004195:Disease Models, Animal; D015785:Eye Diseases, Hereditary / Q000378:metabolism*; D066298:In Vitro Techniques; D007908:Lens, Crystalline / Q000378:metabolism*; D019216:Metals, Heavy / Q000493:pharmacokinetics* / Q000633:toxicity; D011849:Radioactive Tracers; D051381:Rats; D017207:Rats, Sprague-Dawley
D019216:Metals, Heavy; D011849:Radioactive Tracers