title: Oxygen metabolism during and after cardiac surgery: role of CPB.
abstract: BACKGROUND
  Cardiopulmonary bypass (CPB) has been reported to increase oxygen metabolism and to influence the relation between oxygen consumption (VO(2)) and delivery (DO(2)) in the early hours after cardiac surgery. To investigate the role of CPB, we studied oxygen metabolism in coronary artery bypass procedures performed on-pump (CABG) and off-pump (OPCAB).
  
  
  METHODS
  Twenty-five patients were randomized to undergo CABG (n = 14) or OPCAB (n = 11). All patients received the same anesthetic management. Oxygen metabolism variables were assessed before induction of anesthesia and up to 18-hours after surgery.
  
  
  RESULTS
  At baseline, before induction of anesthesia, there were no differences between CABG and OPCAB in oxygen consumption (VO(2)), delivery (DO(2)), or extraction (ExO(2)). After surgery VO(2) and ExO(2) increased in both groups, while DO(2) decreased. No significant differences between CABG and OPCAB were detected in postoperative VO(2), DO(2), and ExO(2) levels. The relation between VO(2) and DO(2) was very similar in CABG and OPCAB patients throughout the study, and no significant differences were detected in slopes and intercepts of the regression lines between CABG and OPCAB at all time points. There was, however, a significant effect of time on the relation between VO(2) and DO(2): this relation was stronger in the postoperative period, and the slope of this relation increased over time as well.
  
  
  CONCLUSIONS
  A hypermetabolic state and progressive and significant increases in the strength of the relationship between VO(2) and DO(2) and in the slope of this relationship occur after both CABG and OPCAB. Cardiopulmonary bypass is not responsible for these changes in oxygen metabolism.
authors.affiliation: Department of Cardiac Surgery, Milan, Italy. aparolari@ccfm.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Parolari
authors.forename: Francesco
authors.initials: F
authors.lastname: Alamanni
authors.forename: Glauco
authors.initials: G
authors.lastname: Juliano
authors.forename: Gianluca
authors.initials: G
authors.lastname: Polvani
authors.forename: Maurizio
authors.initials: M
authors.lastname: Roberto
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Veglia
authors.forename: Andrea
authors.initials: A
authors.lastname: Fumero
authors.forename: Concetta
authors.initials: C
authors.lastname: Carlucci
authors.forename: Paolo
authors.initials: P
authors.lastname: Rona
authors.forename: Claudio
authors.initials: C
authors.lastname: Brambillasca
authors.forename: Erminio
authors.initials: E
authors.lastname: Sisillo
authors.forename: Paolo
authors.initials: P
authors.lastname: Biglioli
mesh_terms: D002315:Cardiopulmonary Bypass / Q000379:methods; D006439:Hemodynamics; D006801:Humans; D007432:Intraoperative Period; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D011184:Postoperative Period
chemical_list: D010100:Oxygen