title: Constituents of Peucedanum zenkeri seeds and their antimicrobial effects.
abstract: The methanol extract of Peucedanum zenkeri L. seeds showed antimicrobial activity which is concentrated in the n-hexane fraction. Bioactivity-guided chromatographic fractionation of the seeds of P. zenkeri led to the isolation and characterization of five major coumarins, umbelliprenin, imperatorin, bergapten, isopimpinellin and byakangelicin, as well as two minor coumarins, 7-methoxy coumarin and 5-hydroxy-8-methoxy psoralen. Amongst the isolated compounds only imperatorin, bergapten and isopimpinellin were found to possess anti-microbial activity.
authors.affiliation: National Center for Natural Products Research, School of Pharmacy, University of Mississippi, MS 38677, USA.
authors.forename: J Ngunde
authors.initials: JN
authors.lastname: Ngwendson
authors.forename: E
authors.initials: E
authors.lastname: Bedir
authors.forename: S M N
authors.initials: SM
authors.lastname: Efange
authors.forename: C O
authors.initials: CO
authors.lastname: Okunji
authors.forename: M M
authors.initials: MM
authors.lastname: Iwu
authors.forename: B G
authors.initials: BG
authors.lastname: Schuster
authors.forename: I A
authors.initials: IA
authors.lastname: Khan
mesh_terms: D000354:Africa, Western; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D019661:Apiaceae / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D003374:Coumarins / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006586:Hexanes; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000737:chemistry; D012639:Seeds / Q000737:chemistry; D012997:Solvents
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D003374:Coumarins; D006586:Hexanes; D012997:Solvents; C026385:n-hexane