title: Cytokinin signal perception and transduction.
abstract: In the past few years, enormous progress has been made in understanding cytokinin perception and signalling. Three cytokinin receptor proteins, which are hybrid histidine kinases, have been identified in Arabidopsis. These receptors may transduce signals in a quantitative rheostat-like fashion, thus permitting long-lasting and continuously variable signalling that is directly dependent on the hormone concentration. Evidence has been provided that downstream signalling is transmitted through a His-to-Asp phospho-relay involving phosphotransmitter and response regulator proteins, typical of two-component systems. On the basis of mutant analysis, protein-protein interaction studies and target gene identification, a cellular network is emerging that links cytokinin activity to both developmental and physiological processes.
authors.affiliation: Freie Universität Berlin, Institut für Biologie, Angewandte Genetik, Albrecht-Thaer-Weg, 6 14195, Berlin, Germany.
authors.forename: Alexander
authors.initials: A
authors.lastname: Heyl
authors.forename: Thomas
authors.initials: T
authors.lastname: Schmülling
mesh_terms: D017360:Arabidopsis / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D029681:Arabidopsis Proteins / Q000235:genetics*; D003583:Cytokinins / Q000494:pharmacology*; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects; D018506:Gene Expression Regulation, Plant / Q000187:drug effects; D015398:Signal Transduction / Q000235:genetics
chemical_list: D029681:Arabidopsis Proteins; D003583:Cytokinins