title: [Selective effect of the antibody to protein SMP-69 on activity of the defence behavior command neurons in grape snail].
abstract: Effects of antibody against serotonin-modulated protein SMP-69 on defence behavior command neurons L-RP11 were studied in semi-intact preparation of snail Helix lucorum. An increase in membrane excitability as well as selective facilitation of neural responses evoked with chemical sensory stimulation of the snail head (0.25-0.5% quinine solution) were determined 1-1.5 hours after antibody application to the neurons. The antibody did not change neural responses evoked with tactile stimulation of the snail head. These effects were similar to those found in L-RP11 neurons after serotonin or cAMP applications as well as after nociceptive sensitization of the snail. It was suggested that protein homologically related the SMP-69 in mammalians was involved in mechanisms of excitability as well as long-term specific plasticity regulation of L-RP11 neurons synaptic inputs from the head chemoreceptors in snail Helix lucorum.
authors.affiliation: A. I. Karaev Institute of Physiology, Azerbaijan National Acad. Sci., 370100, 2 Sharif-Zade St., Baku, Azerbaijan.
authors.forename: A A
authors.initials: AA
authors.lastname: Mekhtiev
authors.forename: S A
authors.initials: SA
authors.lastname: Kozyrev
authors.forename: V P
authors.initials: VP
authors.lastname: Nikitin
authors.forename: V V
authors.initials: VV
authors.lastname: Sherstnev
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D000242:Cyclic AMP / Q000494:pharmacology; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology*; D017952:Ganglia, Invertebrate / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D006372:Helix, Snails / Q000502:physiology*; D008839:Microelectrodes; D009419:Nerve Tissue Proteins / Q000276:immunology / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D010812:Physical Stimulation; D011803:Quinine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D014110:Touch / Q000502:physiology
chemical_list: D000911:Antibodies, Monoclonal; D009419:Nerve Tissue Proteins; D012701:Serotonin; D011803:Quinine; D000242:Cyclic AMP
vernacular_title: Izbiratel'noe vliianie antitel k belku SMP-69 na aktivnost' komandnykh neĭronov oboronitel'nogo povedeniia vinogradnykh ulitok.