[Evaluation of the effect of medicines on biological properties of Clostridium difficile].
The presence of the persistence factors (anti-lysozyme and anti-complement activity) in the vegetative forms of C. difficile was experimentally proved. The effect of different medicines (vitamins B1, B6 and C, prebiotic inulin, probiotics Bifidumbacterin and Enterol) on the persistence factors of C. difficile and microbial resistance to vancomycin, thienam, lincomycin, clindamycin was evaluated. The anti-lysozyme and anti-complement activity of C. difficile was found to decrease under the influence of vitamins B1, B6, C, inulin, exometabolites of bifidobacteria. Under the impact of the preparations used in this study changes in the sensitivity of C. difficile to antibiotics of the lincoamide, carbapenem, glycopeptide groups were found to occur. The data obtained reveal one of the possible mechanisms of the corrective action of the medicines under study on the intestinal microbiocenosis in patients with antibiotic-associated colitis.
Valyshev
A V
AV
Institute of Cellular and Intracellular Symbiosis, Orenburg, Russia.
Kirillov
D A
DA
Pan'kov
A S
AS
Pruss
V F
VF
Bukharin
O V
OV
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D015377:Cilastatin / Q000494:pharmacology; D000077728:Cilastatin, Imipenem Drug Combination; D016360:Clostridioides difficile / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D003169:Complement Inactivator Proteins / Q000032:analysis / Q000378:metabolism; D004338:Drug Combinations; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D004761:Enterocolitis, Pseudomembranous / Q000382:microbiology; D004791:Enzyme Inhibitors / Q000032:analysis / Q000378:metabolism; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D007444:Inulin / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009113:Muramidase / Q000037:antagonists & inhibitors; D019936:Probiotics / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D003169:Complement Inactivator Proteins; D004338:Drug Combinations; D004791:Enzyme Inhibitors; D014815:Vitamins; D015377:Cilastatin; D015378:Imipenem; D007444:Inulin; D000077728:Cilastatin, Imipenem Drug Combination; D009113:Muramidase
Otsenka vliianiia lekarstvennykh preparatov na biologicheskie svoĭstva Clostridium difficile.