Ultrastructural findings in metastatic bronchioloalveolar carcinoma.
This study was prompted by the recent revision of the definition of bronchioloalveolar carcinoma (BAC) that defines BAC, light microscopically, as a non-invasive carcinoma. Doubt has been raised whether BACs retain certain specific microscopic features after becoming invasive or metastatic. We studied 7 cases of metastatic, non-mucinous BAC by electron microscopy. Of these cases, 5 showed Clara cell granules and 1 revealed lamellar bodies. The remaining case did not show ultrastructural features of BAC. These findings suggest that most BACs retain some of their ultrastructural features after becoming metastatic neoplasms.
Tan
Mary Aldrene L
MA
Department of Pathology, North Shore University Hospital, Manhasset, New York, USA.
Teichberg
Saul
S
Roberts
Beth
B
Hajdu
Steven I
SI
D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000737:chemistry / Q000556:secondary / Q000648:ultrastructure*; D000328:Adult; D000368:Aged; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000032:analysis*; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011506:Proteins / Q000032:analysis*; D014598:Uteroglobin
D007797:Laminin; D011506:Proteins; C556389:SCGB1A1 protein, human; D014598:Uteroglobin