title: Cyclooxygenase inhibitors derived from thalidomide.
abstract: Several N-3,5-dimethylphenylphthalimide analogs possessing more potent cyclooxygenase-inhibiting activity than that of aspirin were prepared during structural development studies based on thalidomide. Substituent effects on the activity were investigated.
authors.affiliation: Institute of Molecular & Cellular Biosciences, The University of Tokyo, Japan.
authors.forename: Mamiko
authors.initials: M
authors.lastname: Suizu
authors.forename: Yohei
authors.initials: Y
authors.lastname: Muroya
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kakuta
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kagechika
authors.forename: Aya
authors.initials: A
authors.lastname: Tanatani
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nagasawa
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hashimoto
mesh_terms: D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007527:Isoenzymes / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D013792:Thalidomide; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases