A case-control study on children with Guillain-Barre syndrome in North China.
OBJECTIVE
To explore the risk factors for Guillain-Barre syndrome.


METHODS
Case-control study design was used in 51 cases of Guillain-Barre syndrome, and 51 matched controls. All of the 51 cases in this study had been examined by electrophysiology. Serum IgG antibodies specific for C. jejuni were determined in all the subjects by ELISA. Each case and control were interviewed using an ad hoc questionnaire, including his/her demographic information, onset of the illness, their personal hygiene and so on.


RESULTS
The study showed that Guillain-Barre syndrome was associated with a few factors, such as polio vaccine immunization before onset of illness (OR=7.27), no hand washing after defecation and before meals (OR=6.15). Infection of C. jejuni was strongly associated with the illness (OR=9.5, P<0.001).


CONCLUSIONS
It is suggested that occurrence of Guillain-Barre syndrome may correlate to infection of C. jejuni and poor personal hygiene in children.
Liu
Gai-Fen
GF
Department of Epidemiology, School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100005, China. liugaifen1997@sohu.com
Wu
Zheng-Lai
ZL
Wu
Hu-Sheng
HS
Wang
Quan-Yi
QY
Zhao-Ri
Ge-Tu
GT
Wang
Chun-Yong
CY
Liang
Zhi-Xue
ZX
Cui
Shu-Lan
SL
Zheng
Jian-De
JD
D000293:Adolescent; D002169:Campylobacter Infections / Q000150:complications*; D016123:Campylobacter jejuni / Q000472:pathogenicity; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000453:epidemiology* / Q000209:etiology* / Q000382:microbiology; D006235:Hand Disinfection; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007223:Infant; D008297:Male; D023321:Poliovirus Vaccines / Q000009:adverse effects; D012307:Risk Factors
D007074:Immunoglobulin G; D023321:Poliovirus Vaccines