title: Biliary complications after adult living donor liver transplantation.
abstract: We evaluated the causes and outcomes of biliary complications occurring after adult living donor liver transplantation (ALDLT) in a large patient cohort. Among 46 patients who underwent ALDLT at two different centers early bile duct complications occurred in 11 recipients (23.9%), consisting of leakage from the anastomotic site or from the cut surface of the liver. T-tube-associated biliary complications occurred in four patients. Late complications, primarily anastomotic strictures, occurred in 15 patients (32.6%) at 6.7+/-3.5 months after transplantation. Surgical intervention was generally required for early biliary complications but rarely necessary for late complications. No graft loss was caused by biliary complications. Thus, ALDLT is accompanied by a high rate of biliary complications, which in our series have been of low severity. However, long-term effects on graft function are not yet known.
authors.affiliation: Department of Surgery, The Dumont-UCLA Liver Transplant Center, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095, USA.
authors.forename: C
authors.initials: C
authors.lastname: Fondevila
authors.forename: R M
authors.initials: RM
authors.lastname: Ghobrial
authors.forename: J
authors.initials: J
authors.lastname: Fuster
authors.forename: E
authors.initials: E
authors.lastname: Bombuy
authors.forename: J C
authors.initials: JC
authors.lastname: García-Valdecasas
authors.forename: R W
authors.initials: RW
authors.lastname: Busuttil
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005705:Gallbladder Diseases / Q000453:epidemiology* / Q000209:etiology; D006085:Graft Survival; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects / Q000502:physiology*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome