Primordial germ-cell development: the zebrafish perspective.
Primordial germ cells follow a characteristic developmental path that is manifested in the specialized regulation of basic cell functions and behaviour. Recent studies in zebrafish have greatly enhanced our understanding of the mode of specification of primordial germ cells, cell-fate maintenance and the migration of these cells towards their target, the gonad, where they differentiate into gametes.
Raz
Erez
E
Germ Cell Development, Max-Planck-Institute for Biophysical Chemistry, Am Fassberg 11, 37070 Goettingen, Germany. eraz@gwdg.de
D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000196:embryology / Q000235:genetics; D002454:Cell Differentiation; D002465:Cell Movement; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000235:genetics; D004331:Drosophila melanogaster / Q000166:cytology / Q000196:embryology / Q000235:genetics; D005260:Female; D018507:Gene Expression Regulation, Developmental; D005854:Germ Cells / Q000166:cytology*; D006801:Humans; D008297:Male; D051379:Mice; D019718:Receptors, CXCR4 / Q000235:genetics; D013045:Species Specificity; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; C515256:Cxcl12 protein, mouse; D019718:Receptors, CXCR4