title: Intraperitoneal pressure in children: fill-volume related and impacted by body mass index.
abstract: OBJECTIVE
  Prescription of intraperitoneal volume (IPV) in children on peritoneal dialysis (PD) should be individualized in order to optimize both efficiency and tolerance. Intraperitoneal pressure (IPP) can be used as an objective assessment of IPV. Despite IPP being correlated with IPV, there is an important interindividual variability presumed to be secondary to other implicated factors.
  
  
  METHODS
  Over the past 2 years, we conducted a prospective study in our patients on PD (N = 17). For each child, we recorded, at every third month of follow-up, IPV (in milliliters per square meter body surface area), age, gender, body mass index (BMI), and IPP (measured as centimeters of water), collecting a total of 53 data points.
  
  
  RESULTS
  There was a positive correlation between IPV and IPP (r = 0.36), but this correlation was weak in contrast to the strong correlation noted between BMI and IPP (r = 0.82). Age had a different influence on IPP: in the younger-aged group (< 2 years), IPP decreased with age; in the older-aged group (> 2 years), IPP increased with age. In some infants, we noted a paradoxical result: a low IPV with a high IPP.
  
  
  CONCLUSIONS
  The strong correlation noted between IPP and BMI gives a better understanding of the interindividual variability of the previously described unique relationship between IPP and IPV. The more obese the child (i.e., the higher the BMI), the higher is his IPP for a fixed IPV.
authors.affiliation: Nephrology Dialysis Transplantation Children's Unit, University Hospital, Strasbourg, France. Michel.Fischbach@chru-strasbourg.fr
authors.forename: Michel
authors.initials: M
authors.lastname: Fischbach
authors.forename: Joëlle
authors.initials: J
authors.lastname: Terzic
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Provot
authors.forename: Laurence
authors.initials: L
authors.lastname: Weiss
authors.forename: Valérie
authors.initials: V
authors.lastname: Bergere
authors.forename: Soraya
authors.initials: S
authors.lastname: Menouer
authors.forename: Kenza
authors.initials: K
authors.lastname: Soulami
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D001837:Body Weights and Measures; D002648:Child; D002675:Child, Preschool; D015314:Dialysis Solutions; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010529:Peritoneal Cavity / Q000502:physiology*; D010530:Peritoneal Dialysis / Q000379:methods*; D011312:Pressure; D011446:Prospective Studies
chemical_list: D015314:Dialysis Solutions