Solitary bone metastasis from myxoid liposarcoma.
BACKGROUND
Extrapulmonary metastasis is more common in liposarcoma than in other soft tissue sarcomas. However, osseous metastases are rare.


METHODS
We report the case of a 61-year-old woman with a solitary histologically proven bone metastasis of the right femur from primary myxoid liposarcoma of the left thigh. In September 2000 resection of the primary tumor was performed. Histology showed a high-grade liposarcoma with round cell differentiation. Postoperative radiotherapy with 60 Gy was performed. In a follow-up MRI examination 11 months after initial diagnosis, a suspicious formation in the marrow space of the right proximal femur was detected. CT-guided biopsy was performed and histology showed a metastasis from liposarcoma. PET examination confirmed the metastasis as solitary. Curettage of the metastasis was performed followed by radiotherapy with 60 Gy. The patient was without evidence of disease in the last follow-up.


CONCLUSIONS
No standard treatment exists for the management of solitary extrapulmonary metastases from soft tissue sarcoma. Interdisciplinary cooperation is advised and the therapy concept should be chosen individually.
Mai
S K
SK
Sektion Strahlentherapie, Universitätsklinikum Mannheim, Germany. sabine.mai@radonk.ma.uni-heidelberg.de
Voggenreiter
G
G
Neff
K W
KW
Diehl
S
S
Düber
C
C
Wenz
F
F
D001706:Biopsy; D001858:Bone Nails; D003131:Combined Modality Therapy; D003952:Diagnostic Imaging; D005260:Female; D005266:Femoral Neoplasms / Q000175:diagnosis / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D005269:Femur / Q000473:pathology / Q000601:surgery; D006801:Humans; D018208:Liposarcoma, Myxoid / Q000175:diagnosis / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D012983:Soft Tissue Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D013848:Thigh / Q000473:pathology / Q000601:surgery