The effects of manipulation of puberty on growth.
Short stature in adulthood can be considered as a disability because it can be associated with many difficulties including those of a psychological and social nature. Many factors can influence final adult height such as genetics, the magnitude of growth hormone (GH) secretion, height before puberty, and the onset and duration of puberty. A crucial factor affecting final adult height, however, is the total height achieved during puberty. The combination of GH and gonadotropin-releasing hormone analogues greatly enhances growth and their separate and combined use for the treatment of GH deficiency, central precocious puberty and other diagnoses in children and adolescents is discussed in this article.
Lee
Peter A
PA
Penn State College of Medicine, Milton S. Hershey Medical Center, Hershey, PA 17033, USA. plee@psu.edu
D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000139:chemically induced / Q000503:physiopathology; D047072:Aromatase Inhibitors; D002648:Child; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D005260:Female; D006062:Gonadotropins / Q000502:physiology; D006128:Growth / Q000187:drug effects* / Q000502:physiology*; D006130:Growth Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013006:Growth Hormone / Q000627:therapeutic use; D019382:Human Growth Hormone / Q000172:deficiency; D006801:Humans; D007037:Hypothyroidism / Q000150:complications; D008297:Male; D011627:Puberty / Q000187:drug effects* / Q000502:physiology*; D011629:Puberty, Precocious / Q000188:drug therapy / Q000503:physiopathology; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use
D047072:Aromatase Inhibitors; D004791:Enzyme Inhibitors; D006062:Gonadotropins; D020845:Selective Estrogen Receptor Modulators; D019382:Human Growth Hormone; D013006:Growth Hormone