title: Use of a resorbable hydroxyapatite-collagen chondroitin sulfate material on immediate postextraction sites: a clinical and histologic study.
abstract: This study looked at a bone-substitute biomaterial (Biostite) used to fill bone defects around immediate implants in humans. Ninety-six peri-implant bone defects were treated without the use of membranes, comparing two groups: group A = filling the defect with Biostite, and group B = no defect fill. After 4 to 6 months of healing, group A revealed higher percentages of implants covered by new, bone-like tissue (67% in group A, 34% in group B). Endochondral osteogenesis was demonstrated histologically in the regenerated tissues in alveolar sites treated, allowing the hypothesis of bone induction from the filling material used.
authors.affiliation: BioCRA (Biomaterials Clinical Research Association), Pescara, Italy. al.reb@tin.it
authors.forename: Alberto
authors.initials: A
authors.lastname: Rebaudi
authors.forename: Piero
authors.initials: P
authors.lastname: Silvestrini
authors.forename: Paolo
authors.initials: P
authors.lastname: Trisi
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000539:Alveolar Process / Q000473:pathology; D000543:Alveoloplasty; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use*; D015921:Dental Implants; D006025:Glycosaminoglycans / Q000627:therapeutic use*; D006801:Humans; D006882:Hydroxyapatites / Q000627:therapeutic use*; D010012:Osteogenesis / Q000502:physiology; D013524:Surgical Flaps; D014081:Tooth Extraction; D014945:Wound Healing / Q000502:physiology
chemical_list: C080295:Biostite; D018786:Bone Substitutes; D015921:Dental Implants; D006025:Glycosaminoglycans; D006882:Hydroxyapatites; D003094:Collagen