title: Functionalized amido ketones: new anticonvulsant agents.
abstract: We have reported that functionalized amino acids (FAA) are potent anticonvulsants. Replacing the N-terminal amide group in FAA with phenethyl, styryl, and phenylethynyl units provided a series of functionalized amido ketones (FAK). We show that select FAK exhibit significant anticonvulsant activities thereby providing information about the structural requirements for FAA and FAK bioactivity.
authors.affiliation: Department of Chemistry, University of Houston, Houston, TX 77204-5641, USA.
authors.forename: Cécile
authors.initials: C
authors.lastname: Béguin
authors.forename: Shridhar V
authors.initials: SV
authors.lastname: Andurkar
authors.forename: Albert Y
authors.initials: AY
authors.lastname: Jin
authors.forename: James P
authors.initials: JP
authors.lastname: Stables
authors.forename: Donald F
authors.initials: DF
authors.lastname: Weaver
authors.forename: Harold
authors.initials: H
authors.lastname: Kohn
mesh_terms: D000577:Amides / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D023421:Models, Animal; D051381:Rats; D012640:Seizures / Q000188:drug therapy; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000596:Amino Acids; D000927:Anticonvulsants; D007659:Ketones