title: System for MR image-guided prostate interventions: canine study.
abstract: The purpose of this study was to demonstrate the use of a transrectal system that enables precise magnetic resonance (MR) image guidance and monitoring of prostate interventions. The system used a closed-bore 1.5-T MR imaging unit and enables one to take advantage of the higher signal-to-noise ratio achieved with traditional magnet designs, which is crucial for accurate targeting and monitoring of prostate interventions. In the first of the four canine studies, reliable needle placement, with all needles placed within 2 mm of the desired target site, was achieved. In two other studies, MR imaging was used to monitor distribution of injected contrast agent solution (gadopentetate dimeglumine mixed with trypan blue dye) in and around the prostate, thereby confirming that solution had been delivered to the desired tissue and also detecting faulty injections. In the final study, accurate placement and MR imaging of brachytherapy seeds in the prostate were demonstrated. The described system provides a flexible platform for a variety of minimally invasive MR image-guided therapeutic and diagnostic prostate interventions.
authors.affiliation: Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Ave, Traylor Bldg 330, Baltimore, MD 21205, USA.
authors.forename: Robert C
authors.initials: RC
authors.lastname: Susil
authors.forename: Axel
authors.initials: A
authors.lastname: Krieger
authors.forename: J Andrew
authors.initials: JA
authors.lastname: Derbyshire
authors.forename: Attila
authors.initials: A
authors.lastname: Tanacs
authors.forename: Louis L
authors.initials: LL
authors.lastname: Whitcomb
authors.forename: Gabor
authors.initials: G
authors.lastname: Fichtinger
authors.forename: Ergin
authors.initials: E
authors.lastname: Atalar
mesh_terms: D000818:Animals; D001918:Brachytherapy / Q000379:methods; D003287:Contrast Media / Q000008:administration & dosage; D004285:Dogs; D019786:Gadolinium DTPA / Q000008:administration & dosage; D015552:Injections, Intralesional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011467:Prostate / Q000000981:diagnostic imaging*; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D011859:Radiography; D014343:Trypan Blue / Q000008:administration & dosage
chemical_list: D003287:Contrast Media; D014343:Trypan Blue; D019786:Gadolinium DTPA