Come forth CD1d: Hsp110 in the regulation of intestinal epithelial CD1d expression.
CD1d, a nonclassical MHC class I-like molecule, is prominently expressed on intestinal epithelial cells and is thought to function in the regulation of intestinal intraepithelial lymphocyte activity. Hsp110, an abundant heat shock protein present in essentially all mammalian tissues, has now been shown to upregulate CD1d expression in colonic tissue culture cell lines. Might this abundant chaperone serve an autocrine function in the regulation of CD1d expression?
Nicchitta
Christopher V
CV
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA. c.nicchitta@cellbio.duke.edu
D018949:Antigens, CD1 / Q000235:genetics*; D055610:Antigens, CD1d; D005110:Extracellular Space / Q000378:metabolism; D005786:Gene Expression Regulation; D050957:HSP110 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology*
D018949:Antigens, CD1; D055610:Antigens, CD1d; C526877:CD1D protein, human; D050957:HSP110 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; C097205:HSPH1 protein, human