Serum alpha-fetoprotein screening for hepatoblastoma in children with Beckwith-Wiedemann syndrome or isolated hemihyperplasia.
An elevated risk of hepatoblastoma for children with Beckwith-Wiedemann syndrome or isolated hemihyperplasia is well established. We describe five children with Beckwith-Wiedemann syndrome or isolated hemihyperplasia for whom serial serum alpha-fetoprotein screening, usually in combination with abdominal ultrasound, led to early detection of hepatoblastoma.
Clericuzio
Carol L
CL
Department of Pediatrics, University of New Mexico, ACC-3, Albuquerque, NM 87131, USA.
Chen
Emily
E
McNeil
Dawn Elizabeth
DE
O'Connor
Timothy
T
Zackai
Elaine H
EH
Medne
Livija
L
Tomlinson
Gail
G
DeBaun
Michael
M
D001506:Beckwith-Wiedemann Syndrome / Q000150:complications*; D005260:Female; D018197:Hepatoblastoma / Q000175:diagnosis*; D006801:Humans; D006984:Hypertrophy / Q000150:complications; D007223:Infant; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000175:diagnosis*; D008297:Male; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins