MnSOD polymorphism and breast cancer in a population-based case-control study.
A polymorphism in the signal sequence (Ala-9Val) of the gene encoding the free radical-quenching manganese superoxide dismutase (MnSOD) has been reported to alter the risk for breast cancer. We evaluated this relationship in a population-based case-control study (476 breast cancer cases and 502 controls). Overall, relative risks were not significantly elevated in women with one (RR: 1.27; 95% CI: 0.91-1.77) or two (RR: 1.18; 95% CI: 0.81-1.73) Ala alleles compared to those homozygous for the wild-type Val genotype. Results do not support any overall association of the Ala-9Val MnSOD polymorphism to the development of breast cancer.
Egan
Kathleen M
KM
Department of Medicine, Vanderbilt University Medical Center, Suite 6000 Medical Center East, Nashville, TN 37232-8300, USA. kathleen.egan@vanderbilt.edu
Thompson
Patricia A
PA
Titus-Ernstoff
Linda
L
Moore
Jason H
JH
Ambrosone
Christine B
CB
D000409:Alanine; D000483:Alleles; D019943:Amino Acid Substitution; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D006801:Humans; D008875:Middle Aged; D020125:Mutation, Missense; D011110:Polymorphism, Genetic; D012016:Reference Values; D012306:Risk; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000235:genetics*; D014633:Valine; D044465:White People
D013482:Superoxide Dismutase; D014633:Valine; D000409:Alanine