Paranoid psychosis related to mefloquine antimalarial prophylaxis.
Mefloquine is an important antimalarial drug for treatment and prophylaxis of chloroquine-resistant malaria. Its use has been associated with neuropsychiatric side-effects. We report a case of paranoid psychosis associated with mefloquine occurring in a remote part of Papua New Guinea. Adverse reactions and contraindications are discussed. This case underlines the importance of awareness of neuropsychiatric side-effects with mefloquine use and of taking a careful psychiatric history before prescribing mefloquine.
Fuller
S J
SJ
Sydney University Department of Medicine, Nepean Hospital, Australia.
Naraqi
S
S
Gilessi
G
G
D000328:Adult; D000962:Antimalarials / Q000009:adverse effects*; D006801:Humans; D008297:Male; D015767:Mefloquine / Q000009:adverse effects*; D010259:Paranoid Disorders / Q000139:chemically induced*; D011605:Psychoses, Substance-Induced / Q000209:etiology*
D000962:Antimalarials; D015767:Mefloquine