Dendritic cells as inducers of antimicrobial immunity in vivo.
Models of infection have provided important insight into the function of dendritic cells (DC) in vivo. Several microbial products induce DC maturation via Toll-like receptors, a process that is crucial for the ability of DC to initiate adaptive immune responses. Splenic DC have also been shown to produce IL-12 during infection in vivo. This DC-derived IL-12 might be important to skew T cell responses towards Th1. Microbial infections also induce changes in the DC populations of lymphoid organs, often in a subset-specific manner, manifested as an accumulation and redistribution of DC. Furthermore, data are emerging pointing at an absolute requirement of DC in priming of naïve T cells in vivo.
Sundquist
Malin
M
Department of Clinical Immunology, Göteborg University, Sweden.
Johansson
Cecilia
C
Wick
Mary Jo
MJ
D000818:Animals; D001424:Bacterial Infections / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D056890:Eukaryota / Q000276:immunology; D006801:Humans; D018664:Interleukin-12 / Q000276:immunology; D007891:Leishmania / Q000276:immunology; D008087:Listeria / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology; D051379:Mice; D010272:Parasitic Diseases / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology; D012475:Salmonella / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D051193:Toll-Like Receptors
D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors; D018664:Interleukin-12