Two new pregnane glycosides from Dioscorea futschauensis R. KUNTH.
Two new pregnane glycosides (1, 2) together with two known saponins were isolated from the rhizomes of Dioscorea futschauensis R. KUNTH. The structures of 1 and 2 were established as 16alpha-methoxyl-3beta-[(O-alpha-L-rhamnopyranosyl-(1-->2)-O-[alpha-L-rhamnopyranosyl-(1-->4)]-beta-D-glucopyranosyl)oxy]pregn-5-en-20-one and 21-methoxyl-3beta-[(O-alpha-L-rhamnopyranosyl-(1-->2)-O-[alpha-L-rhamnopyranosyl-(1-->4)]-beta-D-glucopyranosyl)oxy]pregn-5,16-en-20-one, respectively, on the basis of two-dimension NMR (2D NMR) and other spectral analysis. Their in vitro bioactivity against plant pathogenic fungus Pyricularia oryzae and osteoblastic proliferation stimulatory activity in the UMR106 cell line were evaluated.
Liu
Hongwei
H
Department of Natural Products Chemistry, Shenyang Pharmaceutical University, China.
Xiong
Zhili
Z
Li
Famei
F
Qu
Gexia
G
Kobayashi
Hisayoshi
H
Yao
Xinsheng
X
D001203:Ascomycota / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D027742:Dioscorea / Q000737:chemistry*; D005659:Fungicides, Industrial / Q000494:pharmacology; D008401:Gas Chromatography-Mass Spectrometry; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010006:Osteoblasts / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry; D011278:Pregnanes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared
D005659:Fungicides, Industrial; D006027:Glycosides; D011278:Pregnanes