Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling.
Abnormal activity of the dopamine system has been implicated in several psychiatric and neurological illnesses; however, lack of knowledge about the precise sites of dopamine dysfunction has compromised our ability to improve the efficacy and safety of dopamine-related drugs used in treatment modalities. Recent work suggests that dopamine transmission is regulated via the concerted efforts of a cohort of cytoskeletal, adaptor and signaling proteins called dopamine receptor-interacting proteins (DRIPs). The discovery that two DRIPs, calcyon and neuronal Ca(2+) sensor 1 (NCS-1), are upregulated in schizophrenia highlights the possibility that altered protein interactions and defects in Ca(2+) homeostasis might contribute to abnormalities in the brain dopamine system in neuropsychiatric diseases.
Bergson
Clare
C
Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA. cbergson@mail.mcg.edu
Levenson
Robert
R
Goldman-Rakic
Patricia S
PS
Lidow
Michael S
MS
D000818:Animals; D020013:Calcium Signaling / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000502:physiology; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D001523:Mental Disorders / Q000503:physiopathology; D051580:Neuronal Calcium-Sensor Proteins; D009479:Neuropeptides / Q000502:physiology; D011506:Proteins / Q000502:physiology*; D011954:Receptors, Dopamine / Q000502:physiology*; D017447:Receptors, Dopamine D1 / Q000502:physiology; D017448:Receptors, Dopamine D2 / Q000502:physiology
D002135:Calcium-Binding Proteins; D008565:Membrane Proteins; D051580:Neuronal Calcium-Sensor Proteins; D009479:Neuropeptides; D011506:Proteins; D011954:Receptors, Dopamine; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; C405464:calcyon; C101464:frequenin calcium sensor proteins; D004298:Dopamine