[Evaluation oxygen free radicals related index before liver transplantation to forejudge prognosis].
OBJECTIVE
To research the relationship of oxygen free radicals related index before liver transplantation with prognosis.


METHODS
Lipid peroxide (LPO), total antioxidant capacity (TAC), nitric oxide (NO) and total bilirubin (T-BIL) in blood from 18 patients were measured before liver transplantation, and the relationship with prognosis was analyzed.


RESULTS
The blood LPO of death group was (17.13+/-4.16) micromol/L, it was obviously higher than that of survival group (7.97+/-3.52) micromol/L (P<0.05). The blood TAC of survival group was (38.05+/-19.13) kU/L, it was higher than that of death group (32.54+/-3.07) kU/L, but there was no obvious difference(P>0.05). There was no obvious difference between the blood NO of death group was (50.80+/-14.80) micromol/L, and survive group was (150.46+/-19.54) micromol/L (P>0.05). The blood T-BIL of death group was (425.98+/-214.18) micromol/L, it was obviously higher than that of survival group (172.10+/-144.32) micromol/L (P<0.05). So the blood LPO and TAC were chosen as the index to forejudge prognosis, and an equation was established to forecast if the patient would be death or survive: Y(1)=0.329 0 X(1)+0.099 8 X(2)-3.9040, Y(2)=1.352 0 X(1)-0.0500 X(2)-11.4640, X(1) represented serum LPO, X(2) represented serum TAC. 100.0 percent accuracy was forecasted in the survival group by the equation, 83.3 percent accuracy was in the death group. The overall patients were forejudged 94.4 percent accurately.


CONCLUSIONS
Measuring LPO and TAC in blood maybe forejudging prognosis properly and can be used as routine examination before liver transplantation. The equation is preferable to forejudging prognosis, it can be used to choose from high risk patients to improve survival rate of the patients after operation. Therefore, it is valuable in clinical practise.
Liu
Chun
C
The Third Hospital of Peking University, Beijing 100083, China.
Zhou
Xiao-si
XS
Geng
Qiu-ming
QM
D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D005260:Female; D005609:Free Radicals; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D016031:Liver Transplantation / Q000401:mortality; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D011379:Prognosis
D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D010100:Oxygen