title: Intravascular papillary endothelial hyperplasia arising from the upper lip.
abstract: We report a rare case of intravascular papillary endothelial hyperplasia (IPEH) arising from the upper lip. Pathologically, it consisted of a few lobulated masses lined by an incomplete fibrous capsule of variable thickness which was separated from the surrounding tissue and which partially formed papillary structures bearing fibrous stalks and a single layer of endothelium. The capillary formation was poorly defined, and mitotic figures were frequently observed. Immunohistochemically, the endothelial cells were positive for factor VIII related antigen and vimentin, and many cells were positive for PCNA, not only in the solid proliferating area but also in the papillary proliferating area. This case represents IPEH with high proliferative activity.
authors.affiliation: Department of Clinical Pathophysiology, Oral Health Science Center, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan. matsuzak@tdc.ac.jp
authors.forename: Kenichi
authors.initials: K
authors.lastname: Matsuzaka
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Koike
authors.forename: Takashi
authors.initials: T
authors.lastname: Yakushiji
authors.forename: Masaki
authors.initials: M
authors.lastname: Shimono
authors.forename: Takashi
authors.initials: T
authors.lastname: Inoue
mesh_terms: D000328:Adult; D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007150:Immunohistochemistry; D008046:Lip / Q000098:blood supply*; D008297:Male; D008938:Mitosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D014652:Vascular Diseases / Q000473:pathology*; D014746:Vimentin / Q000032:analysis; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D014746:Vimentin; D014841:von Willebrand Factor