Liver ischemic preconditioning: a new strategy for the prevention of ischemia-reperfusion injury.
Ischemic preconditioning renders the liver more tolerant to ischemia-reperfusion injury in warm and cold ischemia-reperfusion models. In general, the application of a 5 to 10-minute period of ischemia followed by 10 minutes of reperfusion confers early effective protection to the liver. Mechanisms responsible for this endogenous protective effect include: (1) transient nitric oxide production during liver preconditioning; (2) diminution of toxic reactive species generated on reperfusion; (3) remote effect on extrahepatic organs such as lung, kidney, and pancreas; (4) preservation of energy metabolism during ischemia; and (5) involvement of nuclear transcription factor and others.
Peralta
C
C
Department Patologia Experimental, CSIC-IDIBAPS, Barcelona, Spain.
Serafin
A
A
Fernández-Zabalegui
L
L
Wu
Z Y
ZY
Roselló-Catafau
J
J
D000818:Animals; D019194:Ischemic Preconditioning / Q000379:methods*; D008099:Liver / Q000098:blood supply*; D008102:Liver Circulation / Q000502:physiology; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000517:prevention & control*; D014157:Transcription Factors / Q000378:metabolism
D016328:NF-kappa B; D017382:Reactive Oxygen Species; D014157:Transcription Factors; D009569:Nitric Oxide