Timing of the effect of acetaminophen on body temperature in patients with acute ischemic stroke.
The authors assessed the time of onset of the hypothermic effect of acetaminophen in 102 patients with acute ischemic stroke. These patients were randomized to treatment with either 1000 mg of acetaminophen (n = 52) or placebo (n = 50), given six times daily. Treatment with high-dose acetaminophen resulted in a 0.26 degrees C (95% CI 0.07 to 0.46 degrees C) lower mean body temperature than placebo treatment within 4 hours. This effect remained present throughout the next 20 hours. A large phase III trial seems warranted.
Dippel
D W J
DW
Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands. d.dippel@erasmusmc.nl
van Breda
E J
EJ
van der Worp
H B
HB
van Gemert
H M A
HM
Kappelle
L J
LJ
Algra
A
A
Koudstaal
P J
PJ
D000082:Acetaminophen / Q000008:administration & dosage* / Q000627:therapeutic use; D000208:Acute Disease; D000368:Aged; D001831:Body Temperature / Q000187:drug effects*; D002545:Brain Ischemia / Q000175:diagnosis / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D020521:Stroke / Q000175:diagnosis / Q000188:drug therapy*; D013997:Time Factors
D000082:Acetaminophen