Immune reconstitution inflammatory syndrome mimicking relapse of AIDS related lymphoma in patients with HIV 1 infection.
People with HIV infection who commence highly active antiretroviral therapy (HAART) occasionally develop reactivation of subclinical infection. This clinical entity is termed immune reconstitution inflammatory syndrome (IRIS) and is defined as a paradoxical deterioration in clinical status as a result of recovery of the immune system during HAART. We present three cases of IRIS following a diagnosis of AIDS related non-Hodgkin's lymphoma that resembled lymphoma relapse.
Powles
T
T
Departments of Oncology and HIV medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK.
Thirlwell
C
C
Nelson
M
M
Bower
M
M
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D001424:Bacterial Infections / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007107:Immune System / Q000382:microbiology* / Q000473:pathology / Q000502:physiology; D007249:Inflammation / Q000175:diagnosis* / Q000382:microbiology; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis*; D008297:Male; D015270:Mycobacterium avium-intracellulare Infection / Q000139:chemically induced / Q000175:diagnosis / Q000473:pathology; D009333:Neck / Q000382:microbiology / Q000473:pathology; D012008:Recurrence; D012038:Regeneration; D013577:Syndrome