Novel imidazolination reaction of alkenes provides an easy access to new alpha,beta-differentiated 1,2-vicinal diamines.
alpha,beta-Differentiated 1,2-vicinal diamines have been efficiently synthesized by using new electrophilic imidazolination reaction of alkenes. The hydrolysis of imidazolines was performed by treatment with 6 M HCl in THF at 70 degrees C without epimerization. Eight examples were examined to give good to excellent yields (87-96%).
Pei
Wei
W
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409-1061, USA.
Timmons
Cody
C
Xu
Xin
X
Wei
Han-Xun
HX
Li
Guigen
G
D000475:Alkenes / Q000737:chemistry*; D003959:Diamines / Q000138:chemical synthesis* / Q000737:chemistry; D006868:Hydrolysis; D007093:Imidazoles / Q000737:chemistry*
D000475:Alkenes; D003959:Diamines; D007093:Imidazoles