title: Pooled analysis of prognostic impact of uPA and PAI-1 in breast cancer patients.
abstract: In this report we present an extension of the pooled analysis of the prognostic impact of urokinase-type plasminogen activator (uPA) and its inhibitor PAI-I in breast cancer patients. We analyzed a different endpoint, metastasis-free survival (MFS). We checked the consistency of the estimates for uPA and PAI-1 for relapse-free survival (RFS) and MFS exploring possible sources of heterogeneity. Nodal status, the most important prognostic factor for breast cancer, introduced heterogeneity in the uPA/PAI-1 survival analyses, reflecting the interaction between nodal status and uPA/PAI-1. The estimates for uPA and PAI-1 were found to be consistent, even when a different transformation of their values was used. The heterogeneity of the separate data sets decreased if the levels of uPA and PAI-1 were ranked, data sets were pooled, and the analyses corrected for the base model that included all traditional prognostic factors, and stratified by data set. We conclude that uPA and PAI-1 are ready to be used in the clinic to help classify breast cancer patients into high and low risk groups.
authors.affiliation: Erasmus MC, Josephine Nefkens Institute, Rm. Be 428, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands. m.look@erasmusmc.nl
authors.forename: Maxime
authors.initials: M
authors.lastname: Look
authors.forename: Wim
authors.initials: W
authors.lastname: van Putten
authors.forename: Michael
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authors.lastname: Duffy
authors.forename: Nadia
authors.initials: N
authors.lastname: Harbeck
authors.forename: Ib Jarle
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authors.lastname: Christensen
authors.forename: Christoph
authors.initials: C
authors.lastname: Thomssen
authors.forename: Ronald
authors.initials: R
authors.lastname: Kates
authors.forename: Frédérique
authors.initials: F
authors.lastname: Spyratos
authors.forename: Mårten
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authors.lastname: Fernö
authors.forename: Serenella
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authors.lastname: Eppenberger-Castori
authors.forename: C G J
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authors.lastname: Fred Sweep
authors.forename: Kurt
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authors.lastname: Ulm
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Peyrat
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Martin
authors.forename: Henri
authors.initials: H
authors.lastname: Magdelenat
authors.forename: Nils
authors.initials: N
authors.lastname: Brünner
authors.forename: Catherine
authors.initials: C
authors.lastname: Duggan
authors.forename: Björn W
authors.initials: BW
authors.lastname: Lisboa
authors.forename: Pär-Ola
authors.initials: PO
authors.lastname: Bendahl
authors.forename: Véronique
authors.initials: V
authors.lastname: Quillien
authors.forename: Alain
authors.initials: A
authors.lastname: Daver
authors.forename: Gabriel
authors.initials: G
authors.lastname: Ricolleau
authors.forename: Marion
authors.initials: M
authors.lastname: Meijer-van Gelder
authors.forename: Peggy
authors.initials: P
authors.lastname: Manders
authors.forename: W
authors.initials: W
authors.lastname: Edward Fiets
authors.forename: Marinus
authors.initials: M
authors.lastname: Blankenstein
authors.forename: Philippe
authors.initials: P
authors.lastname: Broët
authors.forename: Sylvie
authors.initials: S
authors.lastname: Romain
authors.forename: Günther
authors.initials: G
authors.lastname: Daxenbichler
authors.forename: Gudrun
authors.initials: G
authors.lastname: Windbichler
authors.forename: Tanja
authors.initials: T
authors.lastname: Cufer
authors.forename: Simona
authors.initials: S
authors.lastname: Borstnar
authors.forename: Willy
authors.initials: W
authors.lastname: Kueng
authors.forename: Louk
authors.initials: L
authors.lastname: Beex
authors.forename: Jan
authors.initials: J
authors.lastname: Klijn
authors.forename: Nial
authors.initials: N
authors.lastname: O'Higgins
authors.forename: Urs
authors.initials: U
authors.lastname: Eppenberger
authors.forename: Fritz
authors.initials: F
authors.lastname: Jänicke
authors.forename: Manfred
authors.initials: M
authors.lastname: Schmitt
authors.forename: John
authors.initials: J
authors.lastname: Foekens
authors.forename: Pär-Ola
authors.initials: PO
authors.lastname: Bendah
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis*; D011237:Predictive Value of Tests; D011379:Prognosis; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D014568:Urokinase-Type Plasminogen Activator / Q000032:analysis*
chemical_list: D017395:Plasminogen Activator Inhibitor 1; D014568:Urokinase-Type Plasminogen Activator