title: Antifungal activity of fractions and two pure compounds of flowers from Wedelia paludosa (Acmela brasiliensis) (Asteraceae).
abstract: Wedelia paludosa (Acmela brasiliensis) (Asteraceae), a traditionally used native Brazilian medicinal plant, showed antifungal activity against dermatophytes in dilution tests. The hexane, dichloromethane and butanol fractions displayed activity against Epidermophyton floccosum, Trichophyton rubrum and Trichophyton mentagrophytes, with minimal inhibitory concentrations between 250 and 1000 microg/mL. Two pure compounds, identified as kaurenoic acid (1) and luteolin (2), also showed activity against these dermatophytes.
authors.affiliation: Programa de Mestrado em Ciências Farmacêuticas/CCS, Universidade do Vale do Itajaí (UNIVALI), Itajaí, Brazil.
authors.forename: M R K
authors.initials: MR
authors.lastname: Sartori
authors.forename: J B
authors.initials: JB
authors.lastname: Pretto
authors.forename: A B
authors.initials: AB
authors.lastname: Cruz
authors.forename: L F V
authors.initials: LF
authors.lastname: Bresciani
authors.forename: R A
authors.initials: RA
authors.lastname: Yunes
authors.forename: M
authors.initials: M
authors.lastname: Sortino
authors.forename: S A
authors.initials: SA
authors.lastname: Zacchino
authors.forename: V Filho
authors.initials: VF
authors.lastname: Cechinel
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D003470:Culture Media; D004224:Diterpenes / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology; D035264:Flowers / Q000737:chemistry; D005658:Fungi / Q000187:drug effects*; D047311:Luteolin; D000432:Methanol; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D031209:Wedelia / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D003470:Culture Media; D004224:Diterpenes; D005419:Flavonoids; D010936:Plant Extracts; C051436:kaurenoic acid; D047311:Luteolin; D000432:Methanol