title: Inverted sinonasal papilloma--a report of 31 cases and review of the literature.
abstract: Inverted papilloma is an epithelial neoplasm of the lateral nasal wall and adjacent sinuses characterized by a marked propensity for recurrence and a significant association with carcinoma. In this retrospective study we present 31 cases treated by our departments between 1982 and 1999. The aim was to compare our results to those of other authors especially regarding surgical management. The male to female ratio of these patients was 2:1 and most patients were in the 6th and 7th decades of life. Conservative surgery was used in most cases as the initial treatment. The overall recurrence rate was low and there were 3 cases associated with carcinoma. We conclude that the results of conservative surgery in selected cases are comparable to those using radical methods. A review of the literature is presented and particular attention is dedicated to the literature concerning analysis of p53 expression, HPV and Epstein-Barr infection and apoptosis in inverted papilloma.
authors.affiliation: Department of Otorhinolaryngology, Salata, University Hospital Center Zagreb, Zagreb, Croatia.
authors.forename: Miljenko
authors.initials: M
authors.lastname: Bura
authors.forename: Ivan
authors.initials: I
authors.lastname: Vladika
authors.forename: Gorana
authors.initials: G
authors.lastname: Aralica
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Bumber
authors.forename: Zdenko
authors.initials: Z
authors.lastname: Krajina
authors.forename: Lana
authors.initials: L
authors.lastname: Bijelić
authors.forename: Gorazd
authors.initials: G
authors.lastname: Poje
authors.forename: Marica
authors.initials: M
authors.lastname: Zizić
authors.forename: Seven
authors.initials: S
authors.lastname: Seiwerth
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D020031:Epstein-Barr Virus Infections; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009296:Nasal Cavity / Q000473:pathology* / Q000601:surgery*; D009364:Neoplasm Recurrence, Local; D009669:Nose Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery* / Q000821:virology; D018308:Papilloma, Inverted / Q000235:genetics / Q000473:pathology* / Q000601:surgery* / Q000821:virology; D030361:Papillomavirus Infections / Q000150:complications; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis; D014412:Tumor Virus Infections / Q000150:complications
chemical_list: D016159:Tumor Suppressor Protein p53