Anti-inflammatory activity and effect on gastric acid secretion of dehydroleucodine isolated from Artemisia douglasiana.
The effect of Dehydroleucodine (DhL) on gastric acid secretion in rats was investigated at a dose of 40 mg/kg, while its anti-inflammatory effect was investigated in two experimental models: arthritis induced by Freund's adjuvant carrageenan- and cotton pellet-induced granuloma. DhL did not inhibit gastric acid secretion, suggesting that its anti-ulcerogenic effect can be attributed to its action on the mucosa defense factors. On the other hand, DhL inhibited both chronic and acute adjuvant carrageenan-induced inflammation phases, being most effective in the chronic phase. In the granuloma test, DhL also inhibited inflammation. It is suggested that the anti-inflammatory activity of DhL may be attributed to interference with multiple targets on the level of transcription factors, such as NF-kappaB, and cytokines.
Guardia
T
T
Pharmacology Unit, Department of Pharmacy, Faculty of Chemistry, Biochemistry and Pharmacy, National University of San Luis, Chacabuco and Pedernera, C.P. 5.700, San Luis, Argentina. tguardia@unsl.edu.ar
Juarez
A O
AO
Guerreiro
E
E
Guzmán
J A
JA
Pelzer
L
L
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D019306:Artemisia / Q000737:chemistry*; D004195:Disease Models, Animal; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes; C079949:dehydroleucodine