[Population-based study of human papillomavirus infection in high-risk area for cervical cancer in Shanxi Province, China].
OBJECTIVE
To investigate the prevalence of oncogenic type of human papillomavirus (HPV) infection and identify the high risk population for conducting immuno/chemoprevention of cervical cancer.


METHODS
All married women aged 30 to 50 with no history of hysterectomy, pelvic radiation and non-pregnant from certain villages of Xiangyuan and Yangcheng County were invited. This study was conducted through two phases. In phase one, subjects sampled the vaginal secretions using the collectors after signing the informed consent. And physicians sampled exfoliated cells from cervix in the phase two. All the specimens were tested with the Hybrid Capture 2 test. The data was managed and analyzed by VFP and SPSS software.


RESULTS
There were 9,683 women participated in this study. Local women welcomed this study and population compliance rate was 75.4%. In tested population, we found 2,666 subjects of HPV DNA positive and HPV prevalence was 27.5%. The rates of different age group were 24.5% (30-34 yrs), 27.4% (35-39 yrs), 28.2% (40-44 yrs), 27.4% (45-50 yrs) respectively and had no significant differences (P = 0.604). The rates were slightly increased with the higher education level and had no differences (P = 0.106). The rate in mountain areas was higher than that in half-mountain areas (P = 0.001).


CONCLUSIONS
The prevalence of HPV infection is indeed high in this region. Local women and health professionals welcome the activities of cervical cancer screening and prevention. It is an emergent task to improve their sanitary condition and prevent them from cervical cancer in these women. A women health cohort is established successfully among high HPV exposed women in rural China. The extensive biologic specimen repository has been successfully established to simultaneously study the etiology, early detection, and immuno/chemoprevention of cervical cancer.
Shen
Yan-hong
YH
Department of Epidemiology, Cancer Institute, CAMS and PUMC, Beijing 100021, China.
Chen
Feng
F
Huang
Man-ni
MN
Liu
Bin
B
Wang
Xi-xia
XX
Zhao
Fang-hui
FH
Li
Shu-min
SM
Li
Nan
N
Wu
Ling-ying
LY
Rong
Shou-de
SD
Zhang
Wen-hua
WH
Ren
Sheng-da
SD
Huang
Rui-de
RD
Qiao
You-lin
YL
D000328:Adult; D002681:China / Q000453:epidemiology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000517:prevention & control; D015995:Prevalence; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000517:prevention & control; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000517:prevention & control / Q000821:virology*; D014626:Vaginal Smears
D004279:DNA, Viral