title: Impact of HLA-C on acute rejection in liver transplantation.
abstract: Although liver transplants show a special tolerogenic behaviour, rejection remains an important problem that involves several immunological mechanisms, some of which are unknown. Our study sought to analyze the influence of HLA-C polymorphism on short-term liver graft acceptance by HLA-C genotyping of 100 orthotopic liver transplant recipient-donor pairs. Recipients were statified according to the occurrence of acute rejection. HLA-Cw*06 allele appeared to be underrepresented among recipients without versus those with acute rejection or those in control groups. With regard to HLA-C allelic compatibility, the frequency of acute rejection or those in episodes decreased with fewer HLA-C mismatches. These findings suggest the participation of HLA-C molecules in liver graft alloresponses, involving HLA-C genotyping, as well as compatibility.
authors.affiliation: Immunology Service, University Hospital Virgen de la Arrixaca, Murcia, Spain.
authors.forename: M R
authors.initials: MR
authors.lastname: Moya-Quiles
authors.forename: A
authors.initials: A
authors.lastname: Torío
authors.forename: M
authors.initials: M
authors.lastname: Muro
authors.forename: O
authors.initials: O
authors.lastname: Montes-Ares
authors.forename: L
authors.initials: L
authors.lastname: Marin
authors.forename: A
authors.initials: A
authors.lastname: Minguela
authors.forename: F
authors.initials: F
authors.lastname: Sánchez-Bueno
authors.forename: A M
authors.initials: AM
authors.lastname: Garcia-Alonso
authors.forename: P
authors.initials: P
authors.lastname: Parrilla
authors.forename: M R
authors.initials: MR
authors.lastname: Alvarez-López
mesh_terms: D000483:Alleles; D004359:Drug Therapy, Combination; D005838:Genotype; D006084:Graft Rejection / Q000453:epidemiology*; D015236:HLA-C Antigens / Q000097:blood / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007108:Immune Tolerance; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016031:Liver Transplantation / Q000276:immunology*; D012189:Retrospective Studies
chemical_list: D015236:HLA-C Antigens; D007166:Immunosuppressive Agents