title: Glomeruloid microvascular proliferation is associated with p53 expression, germline BRCA1 mutations and an adverse outcome following breast cancer.
abstract: Glomeruloid microvascular proliferation (GMP) in breast cancer independently adversely affected survival (relative risk 1.9, 95% CI: 1.2-3.0), particularly among women who received adjuvant chemotherapy (10-year survival 27 vs 69%, P=0.0003), and was significantly associated with p53 overexpression and BRCA1 germline mutations. The presence of GMP may influence treatment decisions.
authors.affiliation: Tufts University Department of Medicine, Division of Hematology/Oncology, Tufts-New England Medical Center, 750 Washington St., Tufts-NEMC #245 Boston, MA 02111, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Goffin
authors.forename: O
authors.initials: O
authors.lastname: Straume
authors.forename: P O
authors.initials: PO
authors.lastname: Chappuis
authors.forename: J-S
authors.initials: JS
authors.lastname: Brunet
authors.forename: L R
authors.initials: LR
authors.lastname: Bégin
authors.forename: N
authors.initials: N
authors.lastname: Hamel
authors.forename: N
authors.initials: N
authors.lastname: Wong
authors.forename: L A
authors.initials: LA
authors.lastname: Akslen
authors.forename: W D
authors.initials: WD
authors.lastname: Foulkes
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000098:blood supply* / Q000378:metabolism*; D002455:Cell Division; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D018095:Germ-Line Mutation; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000473:pathology*; D011379:Prognosis; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53