title: Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors.
abstract: A salicylate second site binder was linked to three classes of phosphotyrosine mimetics to produce potent protein tyrosine phosphatase 1B (PTP1B) inhibitors which exhibit significant selectivity against other phosphatases including the most homologous member, TCPTP.
authors.affiliation: Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA. zhonghua.pei@abbott.com
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Pei
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Li
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Cele
authors.initials: C
authors.lastname: Abad-Zapatero
authors.forename: Tom
authors.initials: T
authors.lastname: Lubben
authors.forename: Tianyuan
authors.initials: T
authors.lastname: Zhang
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Ballaron
authors.forename: Charles W
authors.initials: CW
authors.lastname: Hutchins
authors.forename: James M
authors.initials: JM
authors.lastname: Trevillyan
authors.forename: Michael R
authors.initials: MR
authors.lastname: Jirousek
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; C516607:PTPN1 protein, human; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases