title: Oral antifungal drug interactions: a mechanistic approach to understanding their cause.
abstract: Oral antifungal drugs are generally regarded as effective and safe when used according to their manufacturer's recommendation. However, when an oral antifungal agent is administered with certain interacting agents or classes of drugs, rare severe iatrogenic adverse experiences including death may occur. This article alerts and demystifies some of the clinically significant oral antifungal drug interactions by exploring their underlying pharmacological basis.
authors.affiliation: Department of Dermatology, University of Minnesota, 420 Delaware Street SE., MMC 98, Minneapolis, MN 55455, USA. hikatz@earthlink.net
authors.forename: H Irving
authors.initials: HI
authors.lastname: Katz
authors.forename: Aditya K
authors.initials: AK
authors.lastname: Gupta
mesh_terms: D000284:Administration, Oral; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D004347:Drug Interactions; D006801:Humans; D009181:Mycoses / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000935:Antifungal Agents