Posterior capsule opacification: comparison of 3 intraocular lenses of different materials and design.
OBJECTIVE
To compare posterior capsule opacification (PCO) after cataract surgery with implantation of 3 intraocular lenses (IOLs) of different materials and design.


METHODS
St. Erik's Eye Hospital, Stockholm, Sweden.


METHODS
In this prospective clinical study, 180 patients had standardized phacoemulsification performed by a single surgeon and were randomized to have implantation of a heparin-surface-modified (HSM) poly(methyl methacrylate) (PMMA) IOL (809C, Pharmacia & Upjohn), a silicone IOL (SI-40NB, Allergan), or an acrylic IOL (AcrySof MA60BM, Alcon). To morphologically evaluate PCO, retroillumination photographs were obtained and analyzed using Evaluation of Posterior Capsule Opacification computer software. The neodymium:YAG (Nd:YAG) capsulotomy rate was recorded.


RESULTS
After 2 years, the HSM PMMA IOL group had significantly more PCO than the silicone and AcrySof IOL groups; the silicone group had significantly more PCO than the AcrySof group (P<.05). The Nd:YAG capsulotomy rate was 20% in the HSM PMMA group, 22% in the silicone group, and 8% in the AcrySof group.


CONCLUSIONS
Patients with an AcrySof IOL developed significantly less PCO than those with a silicone or HSM PMMA IOL with a round-edged design.
Wejde
Gisela
G
St Erik's Eye Hospital, Stockholm, Sweden. gisela.wejde@sankterik.se
Kugelberg
Maria
M
Zetterström
Charlotta
C
D000180:Acrylic Resins; D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000209:etiology*; D020099:Coated Materials, Biocompatible; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000473:pathology*; D019654:Lens Implantation, Intraocular / Q000009:adverse effects*; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification / Q000009:adverse effects; D019904:Polymethyl Methacrylate; D011183:Postoperative Complications; D011446:Prospective Studies; D011474:Prosthesis Design; D012826:Silicone Elastomers
D000180:Acrylic Resins; D020099:Coated Materials, Biocompatible; D012826:Silicone Elastomers; D019904:Polymethyl Methacrylate