title: Tomographic optical breast imaging guided by three-dimensional mammography.
abstract: We introduce a modified Tikhonov regularization method to include three-dimensional x-ray mammography as a prior in the diffuse optical tomography reconstruction. With simulations we show that the optical image reconstruction resolution and contrast are improved by implementing this x-ray-guided spatial constraint. We suggest an approach to find the optimal regularization parameters. The presented preliminary clinical result indicates the utility of the method.
authors.affiliation: Department of Physics, Tufts University, Medford, Massachusetts 02155, USA. angli@nmr.mgh.harvard.edu
authors.forename: Ang
authors.initials: A
authors.lastname: Li
authors.forename: Eric L
authors.initials: EL
authors.lastname: Miller
authors.forename: Misha E
authors.initials: ME
authors.lastname: Kilmer
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Brukilacchio
authors.forename: Tina
authors.initials: T
authors.lastname: Chaves
authors.forename: Jonathan
authors.initials: J
authors.lastname: Stott
authors.forename: Quan
authors.initials: Q
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Wu
authors.forename: MaryAnn
authors.initials: M
authors.lastname: Chorlton
authors.forename: Richard H
authors.initials: RH
authors.lastname: Moore
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Kopans
authors.forename: David A
authors.initials: DA
authors.lastname: Boas
mesh_terms: D001940:Breast; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008327:Mammography; D008962:Models, Theoretical; D055095:Optics and Photonics; D014054:Tomography