[Effect of chemotherapy to ovary function in ovarian malignancy patients undergoing conservative surgery].
OBJECTIVE
To determine the effect of chemotherapy on ovarian endocrine function and menstruation.


METHODS
Menstruation and serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estradiol (E2) levels were observed when the patients with ovarian cancer undergoing one side ovarectomy were followed by chemotherapy.


RESULTS
Abnormal menstruation occurred in 86.7% cases, including 80% amenorrhea and 6.7% oligomenstruate. Menstruation resumed around 2 months after chemotherapy. Serum LH, FSH levels rose and E2 level declined during amenorrhea. No significant change was observed in progesterone or testosterone levels.


CONCLUSIONS
Ovary function impairment may occur in ovarian cancer patient treated by one side ovarectomy followed by chemotherapy. Serum LH, FSH, and E2 levels change and abnormal menstruation are two common manifestations. However, chemotherapy-related amenorrhea is reversible.
Sun
Zheng-yi
ZY
Department of Obstetrics and Gynecology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. sunzhengyi@263.net
Shen
Keng
K
Lang
Jing-he
JH
Huang
Hui-fang
HF
D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000209:etiology*; D002648:Child; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008598:Menstruation; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D010052:Ovariectomy; D010053:Ovary / Q000503:physiopathology*
D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone