Atrial fibrillation induced by simvastatin treatment in a 61-year-old man.
A 61-year-old man developed atrial fibrillation 2 weeks after the administration of simvastatin (5 mg once daily) and recovered to sinus rhythm 3 days after withdrawal of the drug. Electrocardiography had not previously revealed an abnormality except for transient atrial fibrillation and left atrial overloading. Although he has not been given any antiarrhythmic agents, sinus rhythm is being continuously maintained. The timing of the transient atrial fibrillation attack was closely related to the administration of simvastatin. An inhibitory effect of myocardial energy metabolism through ubiquinone synthesis may play a role in the development of atrial fibrillation.
Akahane
Takemi
T
Third Department of Internal Medicine, Nara Medical University, Nara, Japan.
Mizushige
Katsufumi
K
Nishio
Hatsumi
H
Fukui
Hiroshi
H
Kuriyama
Shigeki
S
D001281:Atrial Fibrillation / Q000139:chemically induced* / Q000503:physiopathology; D004562:Electrocardiography; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D006949:Hyperlipidemias / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D019821:Simvastatin / Q000008:administration & dosage / Q000009:adverse effects*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; D019821:Simvastatin