title: Long QT syndrome: novel insights into the mechanisms of cardiac arrhythmias.
abstract: The congenital long QT syndrome is a rare disorder in which mutation carriers are at risk for polymorphic ventricular tachycardia and/or sudden cardiac death. Discovery and analysis of gene mutations associated with variants of this disorder have provided novel insight into mechanisms of cardiac arrhythmia and have raised the possibility of mutation-specific therapeutic intervention.
authors.affiliation: Department of Pharmacology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, P&S 7-401, New York, New York 10032, USA. rsk20@columbia.edu
authors.forename: Robert S
authors.initials: RS
authors.lastname: Kass
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Moss
mesh_terms: D000818:Animals; D005838:Genotype; D006321:Heart / Q000502:physiology; D006801:Humans; D008133:Long QT Syndrome / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy; D009154:Mutation; D010641:Phenotype; D015221:Potassium Channels / Q000378:metabolism; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D015222:Sodium Channels / Q000235:genetics / Q000378:metabolism*
chemical_list: D015221:Potassium Channels; D021122:Protein Subunits; D015222:Sodium Channels