title: Retrospective evaluation of intersubject brain registration.
abstract: Although numerous methods to register brains of different individuals have been proposed, no work has been done, as far as we know, to evaluate and objectively compare the performances of different nonrigid (or elastic) registration methods on the same database of subjects. In this paper, we propose an evaluation framework, based on global and local measures of the relevance of the registration. We have chosen to focus more particularly on the matching of cortical areas, since intersubject registration methods are dedicated to anatomical and functional normalization, and also because other groups have shown the relevance of such registration methods for deep brain structures. Experiments were conducted using 6 methods on a database of 18 subjects. The global measures used show that the quality of the registration is directly related to the transformation's degrees of freedom. More surprisingly, local measures based on the matching of cortical sulci did not show significant differences between rigid and non rigid methods.
authors.affiliation: Projet Vista. IRISA/INRIA-CNRS Rennes, France. pierre.hellier@irisa.fr
authors.forename: P
authors.initials: P
authors.lastname: Hellier
authors.forename: C
authors.initials: C
authors.lastname: Barillot
authors.forename: I
authors.initials: I
authors.lastname: Corouge
authors.forename: B
authors.initials: B
authors.lastname: Gibaud
authors.forename: G
authors.initials: G
authors.lastname: Le Goualher
authors.forename: D L
authors.initials: DL
authors.lastname: Collins
authors.forename: A
authors.initials: A
authors.lastname: Evans
authors.forename: G
authors.initials: G
authors.lastname: Malandain
authors.forename: N
authors.initials: N
authors.lastname: Ayache
authors.forename: G E
authors.initials: GE
authors.lastname: Christensen
authors.forename: H J
authors.initials: HJ
authors.lastname: Johnson
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D016208:Databases, Factual; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods* / Q000592:standards; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards; D008297:Male; D010363:Pattern Recognition, Automated; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted; D016037:Single-Blind Method; D013382:Subtraction Technique