Functionalized amido ketones: new anticonvulsant agents.
We have reported that functionalized amino acids (FAA) are potent anticonvulsants. Replacing the N-terminal amide group in FAA with phenethyl, styryl, and phenylethynyl units provided a series of functionalized amido ketones (FAK). We show that select FAK exhibit significant anticonvulsant activities thereby providing information about the structural requirements for FAA and FAK bioactivity.
Béguin
Cécile
C
Department of Chemistry, University of Houston, Houston, TX 77204-5641, USA.
Andurkar
Shridhar V
SV
Jin
Albert Y
AY
Stables
James P
JP
Weaver
Donald F
DF
Kohn
Harold
H
D000577:Amides / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D007659:Ketones / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D023421:Models, Animal; D051381:Rats; D012640:Seizures / Q000188:drug therapy; D013329:Structure-Activity Relationship
D000577:Amides; D000596:Amino Acids; D000927:Anticonvulsants; D007659:Ketones