title: [Imidazopyrimidodiazepines--new heterocyclic system; synthesis and properties].
abstract: The synthesis of the new tricyclic system ring 6-methyl-2,3,10,11-tetrahydroimidazo (1',2',3'-CD) pyrimido (5,4-b) (1,4) diazepinediones-5,8 is described. The 4-aryl- and 5-amino-imidazopyrimidodiazepines have also been obtained. The synthesis started from derivatives of 2-hydroxy-6-methyl-5-pyrimidine carboxylic acids. Some of the chemical and biological properties of new compounds are described.
authors.affiliation: Katedra i Zakład Chemii Organicznej Akademii Medycznej we Wrocławiu, ul. Grodzka 9, 50-137 Wrocław.
authors.forename: A
authors.initials: A
authors.lastname: Długosz
authors.forename: Z
authors.initials: Z
authors.lastname: Machoń
mesh_terms: D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000929:Antidepressive Agents, Tricyclic; D001381:Azepines; D007093:Imidazoles
vernacular_title: Imidazopirymidodiazepiny--nowy układ heterocykliczny. Synteza i właściwości.