title: Fixed low-dose combination therapy: current recommendations.
abstract: JNC-7 recommends initiating combination therapy in specific circumstances. Hypertension involves numerous body systems; interrupting only one of these systems with monotherapy is frequently insufficient to achieve control. Altering two systems by combining drugs with different mechanisms of action increases the likelihood of control.
authors.affiliation: Medical College of Georgia, USA.
authors.forename: L Michael
authors.initials: LM
authors.lastname: Prisant
mesh_terms: D001741:Black or African American; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D048909:Diabetes Complications; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000208:ethnology; D017410:Practice Guidelines as Topic; D014481:United States; D044465:White People
chemical_list: D000959:Antihypertensive Agents