title: Structure activity studies of a novel cytotoxic benzodiazepine.
abstract: Analogues of Bz-423, a pro-apoptotic 1,4-benzodiazepine with potent activity in animal models of systemic lupus erythematosus and rheumatoid arthritis, have been designed, synthesized, and evaluated in cell-culture assays. The results of these experiments have defined the structural elements of this new cytotoxic agent required for activity.
authors.affiliation: Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, MI 48109-1055, USA.
authors.forename: Anthony
authors.initials: A
authors.lastname: Boitano
authors.forename: Cory D
authors.initials: CD
authors.lastname: Emal
authors.forename: Francesco
authors.initials: F
authors.lastname: Leonetti
authors.forename: Neal B
authors.initials: NB
authors.lastname: Blatt
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Dineen
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Ellman
authors.forename: William R
authors.initials: WR
authors.lastname: Roush
authors.forename: Anthony W
authors.initials: AW
authors.lastname: Opipari
authors.forename: Gary D
authors.initials: GD
authors.lastname: Glick
mesh_terms: D000818:Animals; D001168:Arthritis / Q000188:drug therapy; D001569:Benzodiazepines / Q000737:chemistry* / Q000633:toxicity*; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D008177:Lupus Vulgaris / Q000188:drug therapy; D013329:Structure-Activity Relationship
chemical_list: D001569:Benzodiazepines; C468549:Bz-423