The impact of combinatorial chemistry on drug discovery.
This review will firstly present recent examples in the fields of immobilized arrays and dynamic combinatorial chemistry. The article will then emphasize the impact of combinatorial chemistry on target-focused libraries, demonstrating the usefulness of matrix-formatting for structure-activity relationship analysis and/or the advancement in library design and evaluation.
Lee
Alice
A
Johnson & Johnson Pharmaceutical Research & Development, 3210 Merryfield Row, San Diego, CA 92121, USA.
Breitenbucher
J Guy
JG
D000818:Animals; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis