title: Psychomotor development in children exposed in utero to benzodiazepines, antidepressants, neuroleptics, and anti-epileptics.
abstract: We did a follow-up study based upon a regional prescription register in Denmark. We identified all 435 women who in the period 1991-1996 had redeemed a prescription for CNS drugs during pregnancy. Among the rest of the pregnant women we randomly selected 1304 women who also had given birth to a child in the same region and period. We looked up the local health nurses Boel test results which were available for about 80%. Any abnormal test result was seen much more frequently among exposed (16%) than for not exposed (4%). The study has several limitations but raises concern that should be addressed in other and better designed studies.
authors.affiliation: Department of Clinical Epidemiology, Aarhus University and Aalborg Hospitals, Stengade 10, Box 561, Aalborg, Denmark. jenstm@dadlnet.dk
authors.forename: J T
authors.initials: JT
authors.lastname: Mortensen
authors.forename: J
authors.initials: J
authors.lastname: Olsen
authors.forename: H
authors.initials: H
authors.lastname: Larsen
authors.forename: J
authors.initials: J
authors.lastname: Bendsen
authors.forename: C
authors.initials: C
authors.lastname: Obel
authors.forename: H T
authors.initials: HT
authors.lastname: Sørensen
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D001569:Benzodiazepines / Q000009:adverse effects*; D016022:Case-Control Studies; D002657:Child Development / Q000187:drug effects*; D000075202:Contraindications; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D016015:Logistic Models; D018811:Maternal Exposure / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011596:Psychomotor Disorders / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D011619:Psychotropic Drugs / Q000009:adverse effects*; D012042:Registries; D012307:Risk Factors
chemical_list: D000927:Anticonvulsants; D011619:Psychotropic Drugs; D001569:Benzodiazepines