The role of p27Kip1 in proteasome inhibitor induced apoptosis.
Proteasome inhibitors are potent inducers of cell death. The cytotoxic effect of proteasome inhibitors in general appears to be selective for proliferating cells, while quiescent cells seem to be protected. Conflicting results have been reported on the role of the CKI p27Kip1 either in promoting or inhibiting apoptosis mediated by proteasome inhibitors and other drugs. Here I discuss the role of p27Kip1 in apoptosis and chemotherapy of cancer.
Drexler
Hannes C A
HC
Max Planck Institute for Physiological and Clinical Research, Department of Molecular Cell Biology, Bad Nauheim, Germany. h.drexler@kerckhoff.mpg.de
D017209:Apoptosis / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D050760:Cyclin-Dependent Kinase Inhibitor p27; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D004358:Drug Therapy; D006801:Humans; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors / Q000378:metabolism*; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology; D011480:Protease Inhibitors / Q000494:pharmacology; D046988:Proteasome Endopeptidase Complex; D025521:Tumor Suppressor Proteins / Q000378:metabolism*; D020298:U937 Cells
D018797:Cell Cycle Proteins; D009097:Multienzyme Complexes; D011480:Protease Inhibitors; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex