Altered trkB neurotrophin receptor activation does not influence the N-methyl-D-aspartate receptor antagonist-mediated neurotoxicity in mouse posterior cingulate cortex.
Non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists produce toxic effects in the limbic cortex of rodent brain. NMDA antagonists also increase the expression of brain-derived neurotrophic factor (BDNF) mRNA in the same brain areas. The aim of this study was to investigate whether increased BDNF signalling plays a role in the NMDA-mediated toxic effect by using transgenic mice with modified BDNF signalling and HSP-70 expression as an indicator of toxicity. Neither the enhanced nor the reduced trkB activity influenced MK-801-induced neurotoxic effects in the posterior cingulate cortex of mouse brain, which indicates that increased BDNF production neither protects nor exacerbates neurotoxic effects of NMDA receptor antagonists.
Väisänen
Jussi
J
A.I. Virtanen Institute, University of Kuopio, Kuopio, Finland.
Saarelainen
Tommi
T
Koponen
Eija
E
Castrén
Eero
E
D000818:Animals; D001345:Autoradiography; D001522:Behavior, Animal / Q000187:drug effects; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D006179:Gyrus Cinguli / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism; D017403:In Situ Hybridization; D051379:Mice; D008822:Mice, Transgenic; D009043:Motor Activity / Q000187:drug effects; D016376:Oligonucleotides, Antisense / Q000378:metabolism; D010759:Phosphorus Isotopes; D020033:Protein Isoforms / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D020813:Receptor, trkB / Q000235:genetics / Q000378:metabolism*
D018691:Excitatory Amino Acid Antagonists; D018840:HSP70 Heat-Shock Proteins; D016376:Oligonucleotides, Antisense; D010759:Phosphorus Isotopes; D020033:Protein Isoforms; D012333:RNA, Messenger; D016291:Dizocilpine Maleate; D020813:Receptor, trkB