A chemical genomics approach to understanding drug action.
The complete collection of yeast deletion strains represents a unique, living biological computer for understanding gene function. The molecular 'barcodes' present in each of the deletion strains allow a quantitative ranking of the importance of any gene under any experimental condition of choice. In this article, some of the recent results generated from experiments that exploit the yeast deletion collection to understand mechanisms of drug action are discussed.
Giaever
Guri
G
Stanford Genome Technology Center, 855 California Avenue, Palo Alto, CA 94304, USA. ggiaever@stanford.edu
D004353:Drug Evaluation, Preclinical; D023281:Genomics; D010600:Pharmacology / Q000639:trends*