title: A new iridoid glycoside with nerve growth factor-potentiating activity, gelsemiol 6'-trans-caffeoyl-1-glucoside, from Verbena littoralis.
abstract: A new iridoid glycoside, gelsemiol 6'-trans-caffeoyl-1-glucoside (1), was isolated from Verbena littoralis, together with four known phenylethanoid glycosides, acteoside (2), 2'-acetylacteoside (3), jionoside (4), and isoverbascoside (5). Their structures were elucidated by spectral data. Compound 1 showed weak enhancement of nerve growth factor (NGF)-mediated neurite outgrowth from PC12D cells.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
authors.forename: Yushan
authors.initials: Y
authors.lastname: Li
authors.forename: Masami
authors.initials: M
authors.lastname: Ishibashi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Satake
authors.forename: Yasukatsu
authors.initials: Y
authors.lastname: Oshima
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohizumi
mesh_terms: D002109:Caffeic Acids / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D004357:Drug Synergism; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D020932:Nerve Growth Factor / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000648:ultrastructure; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D032412:Verbena / Q000737:chemistry*
chemical_list: D002109:Caffeic Acids; D005960:Glucosides; C483340:gelsemiol 6'-trans-caffeoyl-1-glucoside; D020932:Nerve Growth Factor