title: A new physiological phenomenon of mammalian body for organ and tissue neo-regeneration in vivo: adult stem cell technology in the perspective of literature.
abstract: A new phenomenon by which adult developed mammalian and human body, can neo-regenerate its own tissue/organ in vivo, is recognized as "Desired Metaplasia". Reserve stem cells present in the tissues of adult developed body, are responsible for repair and replacement of lost tissues and cells during life, is plasia. Chronic tissue damage, due to long-standing causative factor, is taken care of and protected by forming resistant tissues, is metaplasia. Both these changes take place at the anatomical abode of the tissues. When stem cells of one tissue are colonized with another tissue/organ system, away from its anatomical abode, the neo-organo-histogenesis takes place by a phenomenon of desired metaplasia. This being new is critically, analytically and scientifically studied and discussed with reference to the available literature. An attempt has been made to establish the scientific account of the phenomenon. The laws of nature and embryology, as well as the basic philosophy responsible for neo-regeneration of tissues and organs in vivo, are discussed. In conclusion, the mammalian and human bodies can neo-regenerate their tissues and organs in vivo by desired metaplasia, provided certain criteria of embryological organogenesis are strictly observed.
authors.affiliation: Department of Surgery, ITS Center for Dental Studies & Research, Regenerative Surgery, Indian Council of Medical Research, Maulana Azad Medical College and associated Lok Nayak Hospital, New Delhi 110 002, India. matapurkar@hotmail.com
authors.forename: B G
authors.initials: BG
authors.lastname: Matapurkar
mesh_terms: D000328:Adult; D006801:Humans; D012038:Regeneration; D013234:Stem Cells / Q000166:cytology*