A model for cGMP signal transduction in Dictyostelium in perspective of 25 years of cGMP research.
The chemoattactant mediated cGMP response of Dictyostelium cells was discovered about twenty-five years ago. Shortly thereafter, guanylyl cyclases, cGMP-phosphodiesterases and cGMP-binding proteins were detected already in lysates, but the encoding genes were discovered only very recently. The deduced proteins appear to be very different from proteins with the same function in metazoa. In this review we discuss these new findings in perspective of the previously obtained biochemical and functional data on cGMP in Dictyostelium.
Bosgraaf
Leonard
L
Department of Biochemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Van Haastert
Peter J M
PJ
D000818:Animals; D003001:Cloning, Molecular / Q000379:methods; D006152:Cyclic GMP / Q000378:metabolism*; D004023:Dictyostelium / Q000235:genetics / Q000502:physiology*; D006162:Guanylate Cyclase / Q000235:genetics / Q000378:metabolism; D007700:Kinetics; D008954:Models, Biological; D009218:Myosins / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000235:genetics / Q000378:metabolism; D010766:Phosphorylation; D015398:Signal Transduction / Q000502:physiology*
D010727:Phosphoric Diester Hydrolases; D009218:Myosins; D006162:Guanylate Cyclase; D006152:Cyclic GMP