No evidence of association between HLA-DRB1 and attention deficit hyperactivity disorder.
OBJECTIVE
There has been a recent resurgence in interest in the role of autoimmunity in childhood neuropsychiatric disorders. Significant association between HLA-DRB1 and attention deficit hyperactivity disorder (ADHD) in a case-control study of 31 subjects has been reported but there have been no other published studies following up these results. We attempted to replicate these findings.


METHODS
In a well-characterized sample of 173 children with ADHD, using a fully automated sequence-specific oligonucleotide method for HLA genotyping, association between ADHD and HLA-DRB1 was tested for using the Transmission Disequilibrium Test and case-control analysis.


RESULTS
Transmission Disequilibrium Test analysis yielded a chi-square of 10.694 with a simulated global P value of 0.1641 for the full sample, and a chi-square value of 11.307 with a simulated global P value of 0.1323 for the complete trios only.


CONCLUSIONS
There was no evidence of association of HLA-DRB1 and ADHD.
Payton
Antony
A
Centre for Integrated Genomic Medical Research, Stopford Building, Manchester University, Manchester, UK.
Turic
Darko
D
Langley
Kate
K
Mills
Sophie
S
Lawson
Deborah C
DC
Van den Bree
Marianne
M
Owen
Michael J
MJ
O'Donovan
Michael C
MC
Ollier
William
W
Worthington
Jane
J
Thapar
Anita
A
D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics* / Q000276:immunology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D015810:Linkage Disequilibrium
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains