Definition of loss of virological response in trials of antiretroviral drugs.
Definition of the time of loss of virological response is important when designing a viral load endpoint for trials of antiretroviral drugs. We assessed whether, in patients who achieved a viral load below 50 copies/ml, two consecutive values above 50 copies/ml was really indicative of loss of response. It was common for the viral load to return to below 50 copies/ml with no change in regimen, suggesting that a higher threshold for defining the loss of response is required.
Staszewski
Schlomo
S
Goethe Universitat, Frankfurt, Germany.
Sabin
Caroline
C
Dauer
Brenda
B
Lepri
Alessandro Cozzi
AC
Phillips
Andrew
A
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D016896:Treatment Outcome; D019562:Viral Load
D019380:Anti-HIV Agents