title: Alkylation of manganese(II) tetraphenylporphyrin by a synthetic antimalarial trioxane.
abstract: The synthesis and the antimalarial activity of a new kind of polycyclic 1,2,4-trioxanes are reported. The alkylation of the heme model MnIITPP by the biologically active (IC 50 = 320 nmol L-1) hemiperketal 2 is presented.
authors.affiliation: UMR 8076 BioCIS, Faculté de Pharmacie, rue J.-B. Clément, F-92296 Châtenay-Malabry, France.
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Berrien
authors.forename: Olivier
authors.initials: O
authors.lastname: Provot
authors.forename: Joëlle
authors.initials: J
authors.lastname: Mayrargue
authors.forename: Michel
authors.initials: M
authors.lastname: Coquillay
authors.forename: Liliane
authors.initials: L
authors.lastname: Cicéron
authors.forename: Frédérick
authors.initials: F
authors.lastname: Gay
authors.forename: Martin
authors.initials: M
authors.lastname: Danis
authors.forename: Anne
authors.initials: A
authors.lastname: Robert
authors.forename: Bernard
authors.initials: B
authors.lastname: Meunier
mesh_terms: D000478:Alkylation; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D018360:Crystallography, X-Ray; D006418:Heme / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008665:Metalloporphyrins / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects / Q000235:genetics
chemical_list: D000962:Antimalarials; D006571:Heterocyclic Compounds; D008665:Metalloporphyrins; C478042:manganese(II) tetraphenylporphyrin; D006418:Heme; D002738:Chloroquine