A rat model for the energetic regulation of gonadotropin secretion: role of the glucose-sensing mechanism in the brain.
Energy availability has been considered to regulate gonadal activity by modulating the release of gonadotropin-releasing hormone (GnRH)/luteinizing hormone (LH) at various reproductive phases, such as lactation and puberty in domestic as well as wild animals. Experimental models with rats and sheep have demonstrated that fasting or glucoprivation suppresses pulsatile LH release. From those experiments, the information on energy deficiency is considered to be detected by specific central sensors and conveyed to the hypothalamus to regulate LH release as well as food intake. Noradrenergic neurons, originating in the medulla oblongata and projecting to the hypothalamic paraventricular nucleus (PVN), is reported to be one of the pathways mediating the response of LH release to energy deficiency. The other component is considered to be an energy-sensing mechanism in the brain. Glucose or other oxidizable fuels may function as a metabolic signal to regulate LH release. Previous studies suggest the presence of a glucose-sensing mechanism in the rat hindbrain. From our previous results in the rat, the ependymocytes lining the wall of the cerebroventricle could possibly serve as a glucose sensor to regulate GnRH/LH release. Greater understanding of the nature of the energy-sensing mechanism in the brain will contribute to the nutritional manipulation of reproductive performance in domestic animals in various conditions.
Kinoshita
M
M
Laboratory of Animal Reproduction, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan.
Moriyama
R
R
Tsukamura
H
H
Maeda
K-I
KI
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000502:physiology*; D004734:Energy Metabolism; D005941:Glucokinase / Q000032:analysis; D005947:Glucose / Q000378:metabolism*; D006062:Gonadotropins / Q000378:metabolism*; D007515:Islets of Langerhans / Q000502:physiology; D008526:Medulla Oblongata / Q000166:cytology / Q000502:physiology; D023421:Models, Animal; D051381:Rats; D015398:Signal Transduction
D006062:Gonadotropins; D005941:Glucokinase; D005947:Glucose