Experiment to determine if a proguanil-resistant strain of P. falciparum would respond to large doses of pyrimethamine.
D016778:Malaria, Falciparum; D010963:Plasmodium falciparum / Q000187:drug effects*; D002727:Proguanil; D011739:Pyrimethamine; D011743:Pyrimidines / Q000494:pharmacology*
D011743:Pyrimidines; D002727:Proguanil; D011739:Pyrimethamine
CHLOROGUANIDE/resistance and sensitivity; PLASMODIUM FALCIPARUM/effect of drugs on; PYRIMIDINES/effects