Protease chymotrypsin mediates the endothelial expression of P- and E-selectin, but not ICAM and VCAM, induced by placental trophoblasts from pre-eclamptic pregnancies.
D015815:Cell Adhesion Molecules / Q000096:biosynthesis; D002478:Cells, Cultured; D002918:Chymotrypsin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003609:Dactinomycin / Q000494:pharmacology; D019040:E-Selectin / Q000096:biosynthesis*; D042783:Endothelial Cells / Q000378:metabolism*; D005260:Female; D006801:Humans; D016328:NF-kappa B / Q000737:chemistry / Q000378:metabolism; D019007:P-Selectin / Q000096:biosynthesis*; D010920:Placenta / Q000166:cytology / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D011225:Pre-Eclampsia / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology; D013917:Thrombin / Q000037:antagonists & inhibitors; D014327:Trophoblasts / Q000502:physiology*; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis; D000511:alpha-Macroglobulins / Q000494:pharmacology
D015815:Cell Adhesion Molecules; D019040:E-Selectin; D016328:NF-kappa B; D019007:P-Selectin; D011500:Protein Synthesis Inhibitors; D012333:RNA, Messenger; D015842:Serine Proteinase Inhibitors; D019010:Vascular Cell Adhesion Molecule-1; D000511:alpha-Macroglobulins; D003609:Dactinomycin; D002918:Chymotrypsin; D013917:Thrombin