Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators.
D000818:Animals; D000831:Animals, Newborn; D002531:Cerebellum / Q000187:drug effects / Q000502:physiology; D018118:Chloride Channels / Q000037:antagonists & inhibitors* / Q000378:metabolism; D003517:Cyclopentanes / Q000494:pharmacology; D004224:Diterpenes; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004347:Drug Interactions; D004553:Electric Conductivity; D005663:Furans / Q000494:pharmacology; D020441:Ginkgo biloba; D046934:Ginkgolides; D005998:Glycine / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D018408:Patch-Clamp Techniques / Q000379:methods; D010936:Plant Extracts / Q000737:chemistry / Q000145:classification / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000494:pharmacology; D011714:Pyrans / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology; D000096983:Ginkgo Extract
D018118:Chloride Channels; D003517:Cyclopentanes; D004224:Diterpenes; D005663:Furans; D046934:Ginkgolides; D005998:Glycine; D007783:Lactones; D010936:Plant Extracts; D010972:Platelet Activating Factor; D011714:Pyrans; D005680:gamma-Aminobutyric Acid; C427345:4-hydroxy-4-tert-butyl-2,3,5,6-tetrahydrothiopyran-1-oxide; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract; C045856:ginkgolide B; C073710:bilobalide