Design, synthesis, and anticancer activity of phosphonic acid diphosphate derivative of adenine-containing butenolide and its water-soluble derivatives of paclitaxel with high antitumor activity.
D015107:4-Butyrolactone / Q000031:analogs & derivatives; D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000187:drug effects; D011756:Diphosphates / Q000737:chemistry; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry; D006801:Humans; D008870:Microtubules / Q000187:drug effects; D063065:Organophosphonates / Q000737:chemistry; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D011355:Prodrugs / Q000138:chemical synthesis / Q000494:pharmacology; D012262:Ribonucleoside Diphosphate Reductase / Q000037:antagonists & inhibitors; D012995:Solubility; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D011756:Diphosphates; D005663:Furans; D063065:Organophosphonates; D011355:Prodrugs; C004511:butenolide; D012262:Ribonucleoside Diphosphate Reductase; D000225:Adenine; D015107:4-Butyrolactone; D017239:Paclitaxel