Rheumatoid fibroblast-like synoviocytes overexpress the chemokine stromal cell-derived factor 1 (CXCL12), which supports distinct patterns and rates of CD4+ and CD8+ T cell migration within synovial tissue.
D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002465:Cell Movement / Q000187:drug effects / Q000276:immunology*; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000235:genetics / Q000378:metabolism*; D005347:Fibroblasts / Q000276:immunology / Q000378:metabolism; D015870:Gene Expression / Q000276:immunology; D006801:Humans; D037342:Pertussis Toxin / Q000494:pharmacology; D019718:Receptors, CXCR4 / Q000378:metabolism; D017154:Stromal Cells / Q000276:immunology / Q000378:metabolism; D013583:Synovial Membrane / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D019010:Vascular Cell Adhesion Molecule-1 / Q000235:genetics / Q000378:metabolism
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D019718:Receptors, CXCR4; D019010:Vascular Cell Adhesion Molecule-1; D037342:Pertussis Toxin