Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt.
D000256:Adenoviridae / Q000235:genetics; D000469:Alkaline Phosphatase / Q000737:chemistry; D000818:Animals; D015153:Blotting, Western; D001835:Body Weight; D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000737:chemistry; D002155:Calsequestrin / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D004452:Echocardiography; D004594:Electrophysiology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D016257:Fura-2 / Q000494:pharmacology; D006352:Heart Ventricles / Q000473:pathology*; D006984:Hypertrophy; D020128:Inhibitory Concentration 50; D007700:Kinetics; D008245:Lysophospholipase / Q000737:chemistry; D051379:Mice; D008822:Mice, Transgenic; D032342:Muscle Cells / Q000378:metabolism; D009929:Organ Size; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins / Q000737:chemistry* / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012433:Ryanodine / Q000494:pharmacology; D019837:Ryanodine Receptor Calcium Release Channel / Q000737:chemistry; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D019284:Thapsigargin / Q000737:chemistry / Q000494:pharmacology; D013997:Time Factors; D014162:Transfection; D019076:Transgenes; D015854:Up-Regulation
D002155:Calsequestrin; D004791:Enzyme Inhibitors; D011518:Proto-Oncogene Proteins; D019837:Ryanodine Receptor Calcium Release Channel; D012433:Ryanodine; D019284:Thapsigargin; C494920:Akt1 protein, rat; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D008245:Lysophospholipase; D000469:Alkaline Phosphatase; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D000252:Calcium-Transporting ATPases; D002118:Calcium; D016257:Fura-2