Cellular vacuolation and mitochondrial cytochrome c release are independent outcomes of Helicobacter pylori vacuolating cytotoxin activity that are each dependent on membrane channel formation.
D000838:Anions; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D045304:Cytochromes c / Q000378:metabolism*; D003603:Cytotoxins / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D049452:Green Fluorescent Proteins; D006367:HeLa Cells; D016480:Helicobacter pylori / Q000378:metabolism*; D006801:Humans; D008164:Luminescent Proteins / Q000378:metabolism; D018942:Macrolides / Q000494:pharmacology; D008856:Microscopy, Fluorescence; D008928:Mitochondria / Q000378:metabolism* / Q000382:microbiology; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D013997:Time Factors; D014617:Vacuoles / Q000378:metabolism
D000838:Anions; D001426:Bacterial Proteins; D003603:Cytotoxins; D008164:Luminescent Proteins; D018942:Macrolides; D011993:Recombinant Fusion Proteins; C074689:VacA protein, Helicobacter pylori; D049452:Green Fluorescent Proteins; C040929:bafilomycin A1; D045304:Cytochromes c