Prevention of the onset and progression of collagen-induced arthritis in rats by the potent p38 mitogen-activated protein kinase inhibitor FR167653.
D000818:Animals; D000843:Ankle Joint / Q000000981:diagnostic imaging / Q000378:metabolism; D000970:Antineoplastic Agents / Q000494:pharmacology; D001169:Arthritis, Experimental / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000517:prevention & control*; D001854:Bone Marrow Cells / Q000166:cytology; D016516:CD4-CD8 Ratio; D002352:Carrier Proteins / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D016207:Cytokines / Q000097:blood; D018450:Disease Progression; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D016173:Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D008562:Membrane Glycoproteins / Q000494:pharmacology; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors*; D010010:Osteoclasts / Q000166:cytology; D011720:Pyrazoles / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D053245:RANK Ligand; D011859:Radiography; D051381:Rats; D011917:Rats, Inbred Lew; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D048051:p38 Mitogen-Activated Protein Kinases
D000970:Antineoplastic Agents; D002352:Carrier Proteins; D016207:Cytokines; D004791:Enzyme Inhibitors; C104334:FR 167653; D007166:Immunosuppressive Agents; D008562:Membrane Glycoproteins; D011720:Pyrazoles; D011725:Pyridines; D053245:RANK Ligand; D014409:Tumor Necrosis Factor-alpha; D016173:Macrophage Colony-Stimulating Factor; D020928:Mitogen-Activated Protein Kinases; D048051:p38 Mitogen-Activated Protein Kinases