Lack of conversion in vivo of delta 4 androstenedione-3, 17 to a more active androgen by passage through the liver.
D000728:Androgens / Q000378:metabolism*; D000735:Androstenedione; D006801:Humans; D008099:Liver / Q000378:metabolism*
D000728:Androgens; D000735:Androstenedione
ANDROGENS/metabolism; LIVER/metabolism