Sensitivity to analogs of thiamine pyrimidine associated with resistance to amethopterin or purine antagonists.
D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists / Q000494:pharmacology*; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D008727:Methotrexate; D011687:Purines; D011743:Pyrimidines; D013831:Thiamine / Q000031:analogs & derivatives
D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists; D011687:Purines; D011743:Pyrimidines; C030986:pyrimidine; D013831:Thiamine; D008727:Methotrexate
CYTOTOXIC DRUGS; FOLIC ACID ANTAGONISTS/effects; LEUKEMIA/therapy; VITAMIN B1/related compounds