Studies on the effect of triton (WR-1339) on guinea pig tissues. III. Tuberculin hypersensitivity and in vitro cytolysis of leucocytes by tuberculin.
The administration of triton WR-1339 (300 mg./kg. subcutaneously) to tuberculin-sensitive guinea pigs 2 hours before the intradermal injection of PPD depresses slightly their skin sensitivity to tuberculin and essentially obliterates the lytic effect of tuberculin on their circulating leucocytes. When leucocytes from tuberculin-sensitive guinea pigs are exposed to triton in vitro at a concentration level attainable in vivo the cells are partially protected against lysis by PPD.
D000818:Animals; D003902:Detergents / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007271:Injections, Intradermal; D007962:Leukocytes; D004364:Pharmaceutical Preparations; D011092:Polyethylene Glycols; D014373:Tuberculin / Q000494:pharmacology*; D014374:Tuberculin Test / Q000187:drug effects*
D003902:Detergents; D004364:Pharmaceutical Preparations; D014373:Tuberculin; D011092:Polyethylene Glycols; C016811:tyloxapol
DETERGENTS/effects; LEUKOCYTES; TUBERCULIN REACTION/effect of drugs on; TUBERCULIN/effects