Susceptibility of certain enzymes of the central nervous system to tetrodotoxin.
The neurotoxic poison from the roe of Fugu, a globe fish living in the waters of Japan, was investigated with reference to its effect on the main oxidation-reduction systems, acetyl-cholinesterase and choline-acetylase in the brain of the guinea-pig.It was found that the poison inhibited the choline-acetylase activity, even in a concentration of 4.4x10(-7). Acetyl-cholinesterase and cytochrome-c-oxidase activities were also inhibited in concentration of 1.3x10(-5) and 0.8x10(-5) respectively.
D000110:Acetylcholinesterase; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002490:Central Nervous System; D002795:Choline O-Acetyltransferase; D002800:Cholinesterase Inhibitors; D004198:Disease Susceptibility; D004950:Esterases; D006168:Guinea Pigs; D007564:Japan; D010084:Oxidation-Reduction; D010088:Oxidoreductases; D011042:Poisons; D013779:Tetrodotoxin
D002800:Cholinesterase Inhibitors; D011042:Poisons; D013779:Tetrodotoxin; D010088:Oxidoreductases; D002795:Choline O-Acetyltransferase; D004950:Esterases; D000110:Acetylcholinesterase
BRAIN/metabolism; CHOLINESTERASE/antagonists; ESTERASES; OXIDASES; POISONS