gamma-Butyrobetaine as a specific antagonist for carnitine in the development of the early chick embryo.
The effect of gamma-butyrobetaine alone and with the addition of carnitine on the development of the early excised chick embryo has been studied. gamma-Butyrobetaine in appropriate amounts exerts an inhibitory effect which can be relieved or annulled by the inclusion of appropriate amounts of carnitine. This has been interpreted as a metabolite-antimetabolite relationship, in which the normal metabolite, carnitine, is antagonized by the structurally closely related gamma-butyrobetaine, and is regarded as evidence of an important role of carnitine in the metabolism of the developing chick embryo.
D001622:Betaine / Q000031:analogs & derivatives; D002331:Carnitine; D002794:Choline / Q000031:analogs & derivatives; D004622:Embryo, Mammalian / Q000187:drug effects*; D004625:Embryo, Nonmammalian / Q000187:drug effects*; D006801:Humans; D014803:Vitamin B Complex / Q000494:pharmacology*
D014803:Vitamin B Complex; D001622:Betaine; C002889:gamma-butyrobetaine; D002794:Choline; D002331:Carnitine
CHOLINE/related compounds; EMBRYO/effect of drugs on; VITAMIN B COMPLEX/effects