Impact of feeding ethanolic extracts of Achyranthes aspera Linn. on reproductive functions in male rats.
Feeding 50% ethanolic extract of A. aspera to male rats resulted in reduced sperm counts, weight of epididymis, serum level of testosterone and testicular activity of 3beta-hydroxysteroid dehydrogenase, while motility of the sperm and activity of the HMG CoA reductase were not affected. Cholesterol level in the testis, incorporation of labelled acetate into cholesterol, 17-ketosteroids in urine and hepatic and fecal bile acids were increased. The results suggest that ethanolic extract of A. aspera caused reproductive toxicity in male rats and the action may be by suppressing the synthesis of androgen.
D015068:17-Ketosteroids / Q000378:metabolism / Q000652:urine; D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D029044:Achyranthes; D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004032:Diet; D004822:Epididymis / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D007248:Infertility, Male; D008099:Liver / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012669:Seminal Vesicles / Q000737:chemistry / Q000187:drug effects*; D012997:Solvents / Q000494:pharmacology; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects*; D013737:Testis / Q000737:chemistry / Q000187:drug effects* / Q000201:enzymology; D013739:Testosterone / Q000097:blood
D015068:17-Ketosteroids; D010936:Plant Extracts; D012997:Solvents; D000431:Ethanol; D013739:Testosterone; D002784:Cholesterol; D015096:3-Hydroxysteroid Dehydrogenases; D006903:Hydroxymethylglutaryl CoA Reductases