title: A study on the stereochemical purity of trandolapril and octahydro-1H-indole-2-carboxylic acid by HPLC method.
abstract: HPLC conditions for the identification of stereoisomers and stereochemical purity of the key intermediate in Trandolapril synthesis, octahydro-1H-indole-2-carboxylic acid, and final drug were elaborated. The chemical and stereochemical purity of synthetic Trandolapril was proved to be as high as 99.3-99.8%, on both non chiral and chiral RP-columns.
mesh_terms: D002264:Carboxylic Acids / Q000032:analysis* / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004340:Drug Contamination; D007211:Indoles / Q000032:analysis* / Q000737:chemistry*; D008968:Molecular Conformation
chemical_list: D002264:Carboxylic Acids; D007211:Indoles; C052035:trandolapril; C030374:indole