Justification of glioma biology beyond a cellular basis of interpretation.
Gliomas as neoplasms primarily arising from and constituted by glial cells would appear to implicate cell types that inherently reflect variation of aspects of a putative reparative process. The prominence of an astrocytic type cell of origin would further perhaps constitute a system of malignant transformation based on aberrant progression in cell proliferation and of cell pathology related to aspects on one hand of a gliosis and on the other of an autonomous process of progressiveness. In such terms, perhaps, one might consider the molecular aspects of gliomatous pathogenesis as simply a process of integral aberration of various aspects of astrocytic or glial cell responsiveness outside the normal confines of the normal reparative process and inherently beyond a strict cellular basis of interpretation in pathobiologic terms of such processes as anti-apoptosis and amplification of growth factor receptivity.
D017209:Apoptosis; D005075:Biological Evolution; D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology*; D002455:Cell Division; D018450:Disease Progression; D005109:Extracellular Matrix / Q000378:metabolism; D005306:Fertilization; D005910:Glioma / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D000860:Hypoxia; D008962:Models, Theoretical