title: Juvenile-onset Leigh syndrome with an acute polyneuropathy at presentation.
abstract: Subacute necrotizing encephalomyelopathy or Leigh syndrome can be associated with a polyneuropathy. By far, the most commonly encountered neuropathy is a chronic neuropathy with features of demyelination, which can be the presenting manifestation of Leigh syndrome. On rare occasions, the neuropathy encountered can represent a more acute process. We describe a rare case of juvenile-onset Leigh syndrome presenting with an acute polyneuropathy.
mesh_terms: D017668:Age of Onset; D002648:Child; D005260:Female; D006801:Humans; D007888:Leigh Disease / Q000175:diagnosis / Q000503:physiopathology*; D035002:Lower Extremity / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D009431:Neural Conduction; D011115:Polyneuropathies / Q000175:diagnosis / Q000503:physiopathology*; D034941:Upper Extremity / Q000503:physiopathology