Self-assembled multivalent vancomycin on cell surfaces against vancomycin-resistant enterococci (VRE).
A vancomycin (Van) derivative self-assembles in a phosphate buffer as a divalent Van and on cell surfaces as a multivalent Van, which offers potent activity against VRE.
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001667:Binding, Competitive; D019281:Dimerization; D016983:Enterococcus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D014640:Vancomycin