Synthesis, immunological activity and theoretical study of new 5-substituted 3-methylisoxazole[5,4-d] 1,2,3-triazin-4-one derivatives.
A new series of 5-substituted 3-methylisoxazole[5,4-d] 1,2,3-triazin-4-one derivatives was prepared and investigated. The immunological activities of the studied compounds were investigated in two murine models of the immune response to sheep erythrocytes (SRBC)--the humoral immune response and delayed type hypersensitivity (DTH). Quantum-chemical calculations were carried out using AM1, a semiempirical method for geometry optimization, estimation of descriptors values and localization of the HOMO and LUMO orbitals.
D000818:Animals; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000276:immunology* / Q000494:pharmacology; D051379:Mice; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D014227:Triazines / Q000138:chemical synthesis* / Q000276:immunology / Q000494:pharmacology
D007555:Isoxazoles; D014227:Triazines