A new biological method for the assay of depolarizing substances using the isolated semispinalis muscle of the chick.
The isolated semispinalis cervicis muscle of a 3 to 10 days old chick has been found to provide a very useful assay method for depolarizing substances. There are three main advantages of this preparation over that of the rectus abdominis of the frog: (a) quick relaxation without any artificial stretching of the muscle, (b) greater sensitivity to depolarizing drugs, and (c) no falling off in sensitivity for at least 2 hr.
D000818:Animals; D002645:Chickens; D005081:Exercise Therapy; D006293:Health Promotion; D006801:Humans; D009132:Muscles / Q000494:pharmacology*; D009334:Neck Muscles; D064170:Paraspinal Muscles; D017568:Rectus Abdominis; D012063:Relaxation; D013131:Spine
MUSCLES/pharmacology