Geraniol, the putative anthelmintic principle of Cymbopogon martinii.
The essential oil of Cymbopogon martinii (palmrosa) and one of its main constituents geraniol were tested for anthelmintic activity (in vitro) employing the nematode, Caenorhabditis elegans. Both the substances showed potent anthelmintic activity. The ED50 of geraniol was found to be 66.7 mcg/mL, suggesting geraniol as the putative anthelmintic principle of palmrosa oil.
D000080462:Acyclic Monoterpenes; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001547:Benzaldehydes / Q000494:pharmacology; D017173:Caenorhabditis elegans / Q000187:drug effects*; D031743:Cymbopogon; D006801:Humans; D007978:Levamisole / Q000494:pharmacology; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013729:Terpenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000080462:Acyclic Monoterpenes; D000871:Anthelmintics; D001547:Benzaldehydes; D010938:Plant Oils; D013729:Terpenes; D007978:Levamisole; C024896:4-anisaldehyde; C007836:geraniol