title: Effect of whole body gamma radiation on hepatic LDH activity, lactate, pyruvate concentration and rate of oxygen consumption in Bufo melanostictus.
abstract: Whole body Co60 gamma radiation induced changes in lactic dehydrogenase (LDH) activity, pyruvate, lactate content and rate of oxygen (O2) consumption in a tropical hibernating anuran (Bufo melanostictus). In 3.5 and 7 Gy treated groups, a significant increase in LDH activity and lactate/pyruvate ratio was observed, whereas a significant decrease in O2 consumption rate was observed in treated animals on post-irradiation day (PID) 1, 5 and 10. Increase in LDH activity was observed on PID-1 in both the treated groups, reached to a peak on PID-5 in 7 Gy treated group and then declined on PID-10.
mesh_terms: D000818:Animals; D002025:Bufonidae; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays / Q000009:adverse effects; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D019344:Lactic Acid / Q000378:metabolism*; D008099:Liver / Q000201:enzymology* / Q000528:radiation effects*; D010101:Oxygen Consumption / Q000528:radiation effects*; D019289:Pyruvic Acid / Q000378:metabolism*; D014916:Whole-Body Irradiation
chemical_list: D019344:Lactic Acid; D019289:Pyruvic Acid; D007770:L-Lactate Dehydrogenase