title: CHRD, a novel domain in the BMP inhibitor chordin, is also found in microbial proteins.
abstract: CHRD (after SWISSPROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. Database searches have revealed several microbial homologues to this domain. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made.
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics*; D019485:Bone Morphogenetic Proteins / Q000037:antagonists & inhibitors; D006023:Glycoproteins / Q000737:chemistry* / Q000235:genetics* / Q000494:pharmacology; D036341:Intercellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D001426:Bacterial Proteins; D019485:Bone Morphogenetic Proteins; D006023:Glycoproteins; D036341:Intercellular Signaling Peptides and Proteins; C054234:chordin