title: Neurological protection provided by candesartan: reviewing the latest study results.
abstract: Arterial hypertension is closely correlated with the occurrence of stroke and also with the loss of cognitive function and dementia. The results of several trials, including Syst-Eur, PROGRESS, and the preliminary findings from SCOPE open the way to the possible prevention of dementia by antihypertensive treatment. In this respect, candesartan seems to be a promising drug as it has been shown to have neuroprotective effects in animal models of cerebral ischaemia and can prevent non-fatal strokes in elderly subjects with arterial hypertension.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D047228:Angiotensin II Type 1 Receptor Blockers; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D001713:Biphenyl Compounds; D003704:Dementia / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D020521:Stroke / Q000209:etiology / Q000517:prevention & control*; D013777:Tetrazoles / Q000627:therapeutic use*
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D018696:Neuroprotective Agents; D013777:Tetrazoles; C081643:candesartan