Increased levels of folic acid reductase as a mechanism of resistance to amethopterin in leukemic cells.
D000818:Animals; D001669:Biochemical Phenomena; D004798:Enzymes / Q000737:chemistry*; D005493:Folic Acid Antagonists / Q000494:pharmacology*; D007942:Leukemia, Experimental; D008727:Methotrexate; D013762:Tetrahydrofolate Dehydrogenase
D004798:Enzymes; D005493:Folic Acid Antagonists; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate
ENZYMES/chemistry; FOLIC ACID ANTAGONISTS/pharmacology; LEUKEMIA/experimental