Enzymatic formation of psychotomimetic metabolites from normally occurring compounds.
An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine , mescaline, and dopamine.
D000818:Animals; D004298:Dopamine; D006213:Hallucinogens / Q000378:metabolism*; D007211:Indoles / Q000378:metabolism*; D004130:N,N-Dimethyltryptamine; D011817:Rabbits; D012701:Serotonin / Q000378:metabolism*; D014363:Tryptamines
D006213:Hallucinogens; D007211:Indoles; D014363:Tryptamines; D012701:Serotonin; C030820:tryptamine; D004298:Dopamine; D004130:N,N-Dimethyltryptamine
HALLUCINOGENS/metabolism; INDOLES/metabolism; SEROTONIN/metabolism