title: VEGF-receptor signal transduction.
abstract: The vascular endothelial growth factor (VEGF) family of ligands and receptors has been the focus of attention in vascular biology for more than a decade. There is now a consensus that the VEGFs are crucial for vascular development and neovascularization in physiological and pathological processes in both embryo and adult. This has facilitated a rapid transition to their use in clinical applications, for example, administration of VEGF ligands to enhance vascularization of ischaemic tissues and, conversely, inhibitors of VEGF-receptor function in anti-angiogenic therapy. More recent data indicate essential roles for the VEGFs in haematopoietic cell function and in lymphangiogenesis.
mesh_terms: D000818:Animals; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D008024:Ligands; D008207:Lymphatic Metastasis / Q000503:physiopathology; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D040262:Receptors, Vascular Endothelial Growth Factor / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction; D013379:Substrate Specificity
chemical_list: D008024:Ligands; D040262:Receptors, Vascular Endothelial Growth Factor