title: [Prevention of severe reactions after iodinated contrast media injection: review of the literature].
abstract: One of the goal of a premedication before contrast agent injection is to decrease their adverse effects. However, no randomized study was published to date on the value of a systematic premedication for the prevention of immediate severe reactions. A knowledge of pathophysiological mechanisms and patients at risk seems to be essential. The allergic mechanism is probably one of the etiologic diagnosis, but this hypothesis needs to be confirmed by a multicenter prospective study. A patient who has had previous allergic reaction with contrast agent should undergo intradermal tests so as to identify and eliminate the culprit contrast medium in order to avoid any subsequent allergic accidents. Indeed, measurement of specific IgEs has not been validated for contrast media. The test dose should be discarded because it is a false security. The eventuality of adverse effects of the drugs used for premedication should not be underestimated.
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003287:Contrast Media / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D019317:Evidence-Based Medicine; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D007275:Injections, Intravenous; D007428:Intradermal Tests / Q000592:standards; D017613:Iodine Compounds / Q000009:adverse effects*; D011292:Premedication / Q000379:methods* / Q000592:standards; D011871:Radiology / Q000379:methods / Q000592:standards; D015203:Reproducibility of Results; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D003287:Contrast Media; D006634:Histamine H1 Antagonists; D017613:Iodine Compounds
vernacular_title: Prévention des réactions sévères après injection de produits de contraste iodés: revue de la littérature.