Sentinel lymph nodes in gynaecological malignancies: frontline between TNM and clinical staging systems?
Numerous investigations have recently proved the importance of sentinel lymph node detection in various malignant tumours. It is widely accepted that this procedure is to be recommended only in patients with early stage tumours. The lymph node status and prognosis are closely related. Appropriate staging is essential in the management of malignant tumours and should be individualised. In many cases, the nodal status does not correlate with the clinical stage of the disease. In this survey, we consider some of the most common gynaecological malignancies and the type of staging most appropriate to them. Differences between these staging systems, and controversies concerning them, are related to the concept of sentinel lymph node investigation. The authors believe that sentinel node sampling is in fact a beneficial method in both early and advanced stage disease for determination of the tumour status and individualisation of surgical interventions.
D016889:Endometrial Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D005833:Genital Neoplasms, Female / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007391:International Cooperation; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging / Q000379:methods* / Q000592:standards*; D017410:Practice Guidelines as Topic / Q000592:standards; D011877:Radionuclide Imaging; D012015:Reference Standards; D021701:Sentinel Lymph Node Biopsy / Q000379:methods* / Q000592:standards*; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D014625:Vaginal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D014846:Vulvar Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology