[Effect of factors on plasma haloperidol concentration/dose ratio].
It has been known that the serum concentration of antipsychotics is varied according to individual case. There are several factors that may affect the plasma levels of antipsychotics; e.g., antipsychotic dose, body weight, interaction with other drugs, enzyme activity in the human liver, age and smoking. The enzyme cytochrome P450 2D6 (CYP2D6) is an important factor affecting the plasma levels of antipsychotics, because CYP2D6 is involved in the metabolism of these drugs. In this paper, we review the effect of several factors on plasma haloperidol concentration.
D000375:Aging / Q000502:physiology; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000097:blood*; D001835:Body Weight; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006220:Haloperidol / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D011110:Polymorphism, Genetic; D012907:Smoking / Q000009:adverse effects
D014150:Antipsychotic Agents; D019389:Cytochrome P-450 CYP2D6; D006220:Haloperidol