Preliminary evaluation of CNS effects of 6-O-substituted chelidonine derivatives.
Eleven new derivatives of chelidonine I, obtained by functionalization of the alkaloid hydroxyl group, have been tested for CNS activity in mice exhibiting statistically significant effects.
D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D053119:Benzophenanthridines; D001600:Berberine Alkaloids; D002490:Central Nervous System / Q000187:drug effects* / Q000502:physiology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008297:Male; D051379:Mice; D010617:Phenanthridines
D000470:Alkaloids; D053119:Benzophenanthridines; D001600:Berberine Alkaloids; D010617:Phenanthridines; C062047:chelidonine