cis-1,4-diaminocyclohexane-Pt(II) and -(IV) adducts with DNA bases and nucleosides.
A series of new platinum(II) and platinum(IV) adducts of type [P(II)(cis-1,4-DACH)LCl]NO(3,) where cis-1,4-DACH=cis-1,4-diaminocyclohexane, and L=9-ethylguanine, 1-methylcytosine, adenine, adenosine, cytosine, cytidine, guanine, and [Pt(IV)(cis-1,4-DACH)Ltrans-(X)(2)Cl]NO(3), (where Y=hydroxo or acetato), were synthesized and characterized by elemental analysis, infrared spectroscopy, and 1H and 195Pt nuclear magnetic resonance spectroscopy.
D003514:Cyclohexylamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D018736:DNA Adducts / Q000737:chemistry* / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry / Q000378:metabolism*; D010984:Platinum / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D003514:Cyclohexylamines; D018736:DNA Adducts; D009705:Nucleosides; C088969:1,4-diaminocyclohexane; D010984:Platinum