Phosphate prodrugs of isophosphoramide mustard.
Dibenzylphosphorobenzyl and phosphorobenzyl analogues of isophosphoramide mustard, an active metabolite of ifosfamide were synthesized. Phosphorobenzyl analogue posseses stronger cytotoxic activity than isophosphoroamide mustard against the cells of several cancer cell lines suggesting the possibility of the use of this compound in Gene-Directed Enzyme-Prodrug Therapy (GDEPT).
D004353:Drug Evaluation, Preclinical; D006801:Humans; D010710:Phosphates / Q000737:chemistry / Q000633:toxicity*; D010752:Phosphoramide Mustards / Q000737:chemistry / Q000633:toxicity*; D011355:Prodrugs / Q000737:chemistry / Q000633:toxicity*; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism
D010710:Phosphates; D010752:Phosphoramide Mustards; D011355:Prodrugs; C027061:isophosphamide mustard