title: [Adenylate cyclase system of the striatum in rats: regulatory properties and effect of gangliosides].
abstract: Gpp[NH]p, forskolin, and NaF were found to activate the activity of adenylate cyclase in vitro in the membrane fraction of the striatum. Gangliosides decreased the level of basal activity of the striatal adenylate cyclase. Gangliosides were shown to modulate the activity of the enzyme through changes in its catalytic properties.
mesh_terms: D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000262:Adenylyl Cyclases / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D005576:Colforsin / Q000494:pharmacology; D005677:G(M1) Ganglioside / Q000494:pharmacology; D019204:GTP-Binding Proteins / Q000378:metabolism; D005732:Gangliosides / Q000502:physiology*; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology; D008297:Male; D017072:Neostriatum / Q000187:drug effects / Q000201:enzymology* / Q000502:physiology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012969:Sodium Fluoride / Q000494:pharmacology
chemical_list: D005732:Gangliosides; D010726:Phosphodiesterase Inhibitors; D005576:Colforsin; D006165:Guanylyl Imidodiphosphate; D005677:G(M1) Ganglioside; D012969:Sodium Fluoride; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases; D015056:1-Methyl-3-isobutylxanthine
vernacular_title: Adenilattsiklaznaia sistema striatuma krys: reguliatornye svoĭstva i vliianie gangliozidov.