title: Ether-induced retrograde amnesia for one-trial conditioning in mice.
abstract: Mice were tested in a situation permitting them to step readily from a small, restrictive platform to a larger one. Conditioned avoidance was established by a single training trial when animals received a shock by stepping from one platform to another. At various intervals after the single punishing shock, subjects were anesthetized with diethyl ether. Interference with retention, tested 1 day later, was shown for intervals up to 24 minutes, at which time ether no longer appeared to influence the subsequent response.
mesh_terms: D000647:Amnesia; D000648:Amnesia, Retrograde; D000818:Animals; D001362:Avoidance Learning; D004986:Ether / Q000494:pharmacology*; D007858:Learning; D008297:Male; D051379:Mice
chemical_list: D004986:Ether
keywords: AMNESIA/experimental; ETHER, ETHYL/pharmacology; LEARNING