Genetic polymorphisms in the expression and treatment of neuropsychiatric disorders.
Recent advances in molecular genetics have greatly increased the understanding of the pathophysiology of certain neurobehavioral disorders and the core symptoms of these disorders. This paper reviews key concepts important in understanding the genetics of neuropsychiatric disorders, and gives an overview of several different types of genetic disorders, including trinucleotide repeat disorders, and functional polymorphisms of monoamine neurotransmitter systems.
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism; D001692:Biological Transport; D001927:Brain Diseases / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D001523:Mental Disorders / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D011110:Polymorphism, Genetic; D011950:Receptors, Cholinergic / Q000096:biosynthesis / Q000235:genetics; D011954:Receptors, Dopamine / Q000096:biosynthesis / Q000235:genetics; D011985:Receptors, Serotonin / Q000096:biosynthesis / Q000235:genetics; D019680:Trinucleotide Repeat Expansion
D015306:Biogenic Monoamines; D026901:Membrane Transport Proteins; D011950:Receptors, Cholinergic; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin