Aurora A and mitotic commitment.
A remarkable study published in this issue of Cell reveals a key role of Aurora A protein kinase in G2/M progression. To achieve this role, Aurora A acts in conjunction with the LIM protein Ajuba, which functions as an activating factor.
D000818:Animals; D064096:Aurora Kinase A; D064127:Aurora Kinases; D018797:Cell Cycle Proteins; D016195:G2 Phase; D018398:Homeodomain Proteins / Q000502:physiology*; D006801:Humans; D060588:LIM Domain Proteins; D008938:Mitosis; D011485:Protein Binding; D011494:Protein Kinases / Q000378:metabolism / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases; D014981:Xenopus; D029867:Xenopus Proteins
C485608:AJUBA protein, human; C119385:Ajuba protein, rat; D018797:Cell Cycle Proteins; D018398:Homeodomain Proteins; D060588:LIM Domain Proteins; D029867:Xenopus Proteins; D011494:Protein Kinases; C112134:AURKA protein, Xenopus; C576920:Aurka protein, rat; D064096:Aurora Kinase A; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases