Neurological protection provided by candesartan: reviewing the latest study results.
Arterial hypertension is closely correlated with the occurrence of stroke and also with the loss of cognitive function and dementia. The results of several trials, including Syst-Eur, PROGRESS, and the preliminary findings from SCOPE open the way to the possible prevention of dementia by antihypertensive treatment. In this respect, candesartan seems to be a promising drug as it has been shown to have neuroprotective effects in animal models of cerebral ischaemia and can prevent non-fatal strokes in elderly subjects with arterial hypertension.
D000368:Aged; D000369:Aged, 80 and over; D047228:Angiotensin II Type 1 Receptor Blockers; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D001713:Biphenyl Compounds; D003704:Dementia / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D020521:Stroke / Q000209:etiology / Q000517:prevention & control*; D013777:Tetrazoles / Q000627:therapeutic use*
D047228:Angiotensin II Type 1 Receptor Blockers; D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D018696:Neuroprotective Agents; D013777:Tetrazoles; C081643:candesartan