Gamma-radiation dose-rate effects on DNA damage and toxicity in bacterial cells.
In order to investigate the relationship between radiation dose-rate and bacterial DNA damage as well as general cellular toxicity, two recombinant Escherichia coli strains, DPD2794 and GC2 were used. Following gamma-ray irradiation, these bioluminescent bacteria showed quantitative stress responses in terms of DNA damage and general toxicity depending on the dose rates of energy deposition, i.e. dose-rate of radiation. In addition, an inverse relationship was found, at lower dose rates between 0.5 and 1 Gy/h and a parabolic relationship at dose rates between 0.5 and 2.6 Gy/h.
D017209:Apoptosis / Q000528:radiation effects*; D004249:DNA Damage; D004269:DNA, Bacterial / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004926:Escherichia coli / Q000145:classification / Q000235:genetics / Q000254:growth & development* / Q000528:radiation effects*; D005720:Gamma Rays; D011829:Radiation Dosage; D013045:Species Specificity
D004269:DNA, Bacterial