Synthesis, physicochemical properties and biological activity of 2,6-disubstituted 7-methylpurines and the 7,9-dialkyl analogues.
The preparation of several derivatives of 2,6-disubstituted-7-methylpurines and the 7,9-dialkyl analogues possessing a potential cytotoxic or cytostatic activity has been described. These compounds were tested for biological activity using a method for the determination of the toxic effects of chemical compounds on the growth of green alga Chlorella vulgaris, Beijerinck 1890. The effective concentration (EC50) was calculated.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002708:Chlorella / Q000187:drug effects; D000460:Chlorophyta / Q000187:drug effects; D011687:Purines / Q000138:chemical synthesis* / Q000494:pharmacology*
D011687:Purines