title: Studies on infection and immunity in experimental typhoid fever. III. Effect of prophylactic immunization.
abstract: A study was made of the efficacy of various antityphoid immunizing agents in immunizing chimpanzees against typhoid fever produced by feeding viable S. typhosa. It was found that both acetone-killed and heat-killed, phenol-preserved typhoid vaccines were effective in protecting against infection induced with either homologous or heterologous strains of typhoid bacilli. Purified O antigen induced no discernible protection, but some immunity was afforded by the administration of purified Vi antigen.
mesh_terms: D000818:Animals; D000941:Antigens; D006801:Humans; D007109:Immunity; D007114:Immunization; D019081:O Antigens; D002679:Pan troglodytes; D012485:Salmonella typhi; D014435:Typhoid Fever / Q000276:immunology*; D014436:Typhoid-Paratyphoid Vaccines; D014611:Vaccination
chemical_list: D000941:Antigens; D019081:O Antigens; D014436:Typhoid-Paratyphoid Vaccines
keywords: TYPHOID/immunology