2-pyrrolidinone moiety is not critical for the cognition-enhancing activity of piracetam-like drugs.
Following the indications of previous work, 2-pyrrolidinone moiety of piracetam and piracetam-like compounds has been opened to the corresponding amide derivatives. As found previously in the case of 1,4-diazabicyclo[4.3.0]nonan-9-one compounds, the cognition-enhancing activity of 2-pyrrolidinone compounds is maintained in most cases, suggesting that this moiety is not crucial for activity.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D015195:Drug Design; D051379:Mice; D018697:Nootropic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010889:Piracetam / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011760:Pyrrolidinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D018697:Nootropic Agents; D011760:Pyrrolidinones; C028537:2-pyrrolidone; D010889:Piracetam