Triplication (/alphaalphaalpha anti3.7) or deletion (-alpha3.7/) association in Argentinian beta-thalassemic carriers.
Prevalence of alpha gene triplication or deletion in beta-thalassemia carriers was studied in 109 unrelated individuals in Rosario, Argentina. In different populations -alpha(3.7) allele presents a higher prevalence than alphaalphaalpha(anti3.7); thus, alpha-thalassemia associated with beta-thalassemia is more frequently observed. Nevertheless, this event was detected in only one case (0.9%), while the association with alpha triplication was present in two subjects (1.8%).
D000328:Adult; D000483:Alleles; D001118:Argentina / Q000453:epidemiology; D001772:Blood Cell Count; D002648:Child; D005260:Female; D017353:Gene Deletion; D020440:Gene Duplication; D005914:Globins / Q000235:genetics*; D006454:Hemoglobins / Q000378:metabolism; D006579:Heterozygote; D006801:Humans; D007223:Infant; D008297:Male; D015995:Prevalence; D017085:alpha-Thalassemia / Q000097:blood / Q000453:epidemiology / Q000235:genetics*
D006454:Hemoglobins; D005914:Globins