title: Screening for hemoglobin disorders in Thai pregnant women by England and Frazer's calculation method.
abstract: OBJECTIVE
  Our objective was to perform a preliminary study screening for hemoglobin disorders among Thai pregnant women using England and Frazer's calculation method.
  
  
  METHODS
  One hundred and thirty-five pregnant women who receive antenatal laboratory check-up from the Out-Patient Division, King Chulalongkorn Memorial Hospital.
  
  
  METHODS
  Endocrine disruptor testing and assessment (EDTA) blood specimens from each patient were analyzed by two methods in order to screen for inherited hemoglobin disorders. Hemoglobin and genotype analysis was set as the confirmation method. Blood indices investigation performed by automated hematology analyzer was set for England and Frazer's calculation method as the screening method.
  
  
  RESULTS
  The sensitivity and specificity of the method using England and Frazer's calculation were 92.3 and 100%. False positive and false negative results were 0% and 7.7%.
  
  
  CONCLUSIONS
  England and Frazer's calculation method can be an alternative method that can help screen for hemoglobin E disorders in pregnant women.
mesh_terms: D003362:Cost-Benefit Analysis; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D017048:Health Care Costs; D006446:Hemoglobin E; D006453:Hemoglobinopathies / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008403:Mass Screening / Q000191:economics / Q000379:methods* / Q000592:standards; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: D006446:Hemoglobin E