Calcium signalling: the ups and downs of protein kinase C.
Oscillations in intracellular calcium levels control a plethora of physiological processes, but how they are decoded by a cell remains unclear. In a recent study, advances in FRET technology have been used to describe how calcium oscillations are decoded through phase-locked oscillations in substrate phosphorylation catalysed by protein kinase C.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D031541:Fluorescence Resonance Energy Transfer; D006801:Humans; D010766:Phosphorylation; D011493:Protein Kinase C / Q000378:metabolism*
D011493:Protein Kinase C; D002118:Calcium