Infection and venous thrombosis.
Chlamydia pneumoniae infection has been linked to atherosclerosis, but a possible relationship with venous thromboembolism (VTE) had not been sought. We determined circulating anti-C. pneumoniae antibody levels in patients with VTE. Fifty-four percent of the cases and 15.9% of the controls had specific IgG titers of at least 256 (p<0.0001). The crude odds ratio for VTE was 6.2 (95% CI, 3.8-10.1), and rose to 7.7 (4.5-13.2) after excluding subjects carrying the factor V Arg 506 Gln or factor II G 20210 A mutations. Other studies did not confirm such an association or found a lower odds ratio. This association remains to be confirmed in other case-control or prospective studies.
D000907:Antibodies, Bacterial / Q000097:blood; D023521:Chlamydophila Infections / Q000453:epidemiology*; D016993:Chlamydophila pneumoniae / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D011655:Pulmonary Embolism / Q000453:epidemiology / Q000382:microbiology; D016036:Seroepidemiologic Studies; D020246:Venous Thrombosis / Q000453:epidemiology* / Q000382:microbiology*
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G