[Augmentation of cholinergic activity of the neostriatum alters established type of motor behaviour in animals].
Bilateral microinjections of carbacholine into dorsolateral portion of the caudate nucleus head reduced a phasic component, augmented a tonic component of instrumental response, inhibited interstimuluv raisings, normalised posture, and calmed down the dogs under study. They also improved differentiation of meaningful signals. Microinjections of scopolamine into the striatum induced opposite effects. Bilateral injections provided a longer lasting effect on both motor and sensory components of instrumental responses.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D018679:Cholinergic Agonists / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000494:pharmacology; D004285:Dogs; D004558:Electric Stimulation; D008845:Microinjections; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D017072:Neostriatum / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000378:metabolism / Q000502:physiology*
D018679:Cholinergic Agonists; D018680:Cholinergic Antagonists; D011950:Receptors, Cholinergic
Usilenie aktivnosti kholinergicheskoĭ sistemy neostriatuma izmeniaet slozhivshiĭsia tip dvigatel'nogo povedeniia zhivotnykh.