1,2-dithiolan-3-ones and derivatives structurally related to leinamycin. Synthesis and biological evaluation.
Leinamycin, an antitumor antibiotic isolated from Streptomyces sp., shows a 1,2-dithiolan-3-one 1-oxide heterocycle that appears to be involved in the biological activity. Several derivatives related to 1,2-dithiolan-3-one 1-oxide have been prepared and their activity as antineoplastic agents have been investigated. The synthesized compounds did not display a significative antitumor or cytotoxic activity in vitro.
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007769:Lactams; D018942:Macrolides / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000494:pharmacology; D013844:Thiazoles / Q000737:chemistry*; D013871:Thiones / Q000737:chemistry*
D000970:Antineoplastic Agents; D006574:Heterocyclic Compounds, 2-Ring; D007769:Lactams; D018942:Macrolides; D013438:Sulfhydryl Compounds; D013844:Thiazoles; D013871:Thiones; C059000:leinamycin