Regulatory T cells control the development of allergic disease and asthma.
The role of T(H)2 cells in the pathogenesis of allergy and asthma has been well described. However, the immunologic mechanisms that downmodulate and protect against the development of these disorders are poorly characterized. A spectrum of CD4+ T cells, including T(H)1 cells, T(H)3 cells, regulatory T cells, CD25+ T cells, and natural killer T cells might play a critical role in regulating these diseases and are discussed in this review.
D001249:Asthma / Q000209:etiology* / Q000276:immunology; D018797:Cell Cycle Proteins; D006506:Hepatitis A / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000276:immunology; D007108:Immune Tolerance; D047908:Intracellular Signaling Peptides and Proteins; D007694:Killer Cells, Natural / Q000276:immunology; D018448:Models, Immunological; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D014157:Transcription Factors / Q000276:immunology
D018797:Cell Cycle Proteins; D047908:Intracellular Signaling Peptides and Proteins; C509769:TIMELESS protein, human; C509770:Timeless protein, mouse; D014157:Transcription Factors