Development of CD30+ lymphoproliferative disease in mice lacking interferon regulatory factor-1.
Human lymphomas continue to represent a major challenge in oncology, and in particular occur at very high frequencies in AIDS patients. We report here the development of a CD30+ lymphoproliferative disease in mice lacking the proapoptotic transcription factor, interferon regulatory factor-1. These mice most closely represent a model of human anaplastic large-cell lymphoma (ALCL). This mouse model of lymphoma will likely be useful in understanding the development of ALCL and in understanding the development of other closely related CD30+ forms of lymphoma, such as CD30+ Hodgkin's disease and CD30+ cutaneous T-cell lymphoma. This mouse model will also be useful in testing therapies for different forms of CD30+ lymphoma, in particular anti-CD30-based therapies.
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics*; D007150:Immunohistochemistry; D050856:Interferon Regulatory Factor-1; D017730:Ki-1 Antigen / Q000378:metabolism*; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D008206:Lymphatic Diseases / Q000378:metabolism / Q000473:pathology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D008232:Lymphoproliferative Disorders / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D010750:Phosphoproteins / Q000235:genetics*; D016160:Retinoblastoma Protein / Q000235:genetics; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics
D004268:DNA-Binding Proteins; D050856:Interferon Regulatory Factor-1; C494258:Irf1 protein, mouse; D017730:Ki-1 Antigen; D010750:Phosphoproteins; D016160:Retinoblastoma Protein; D014157:Transcription Factors