[Evaluation of a new method for diagnosing the origin of urinary bleeding by the morphological characteristics of urinary red blood cells].
In this study, we attempted to develop a new method for diagnosing the origin of urinary bleeding by the morphological characteristics of urinary red blood cells (RBC). Seventy-five samples were divided into five types by individual features using phase-contrast microscopy. It was revealed that the ratios of type III, namely acanthocytes, and IV, namely donut-shaped RBC, were significantly higher in patients with glomerular bleeding than those with non-glomerular bleeding. Acanthocytes seemed to be specific to glomerular bleeding, but some urinary samples from patients with glomerular bleeding did not show acanthocytes. Therefore, we suggest that the detection of a combination of acanthocytes and donut-shaped RBC in a urine sample is useful for the diagnosis of glomerular bleeding.
D000050:Acanthocytes / Q000473:pathology*; D015415:Biomarkers / Q000652:urine; D003937:Diagnosis, Differential; D004913:Erythrocytes, Abnormal / Q000473:pathology*; D005260:Female; D006417:Hematuria / Q000652:urine*; D006470:Hemorrhage / Q000175:diagnosis* / Q000652:urine; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis* / Q000652:urine; D007678:Kidney Glomerulus; D008297:Male
D015415:Biomarkers