Role for ganglionic norepinephrine in sympathetic synaptic transmission.
Transmission of nerve impulses in superior cervical sympathetic ganglia of cats and rabbits is markedly enhanced after reserpine-induced depletion of ganglionic norepinephrine. Transmission is also enhanced by administration of adrenergic blocking agents. In contrast, reserpine-induced release of ganglionic norepinephrine in animals pretreated with a monoamine oxidase inhibitor results in a pronounced depression of ganglionic transmission, which lasts until the ganglionic norepinephrine disappears. These results support the concept that norepinephrine in ganglia modulates the action of acetylcholine.
D000109:Acetylcholine; D000200:Action Potentials; D000818:Animals; D002415:Cats; D005724:Ganglia; D005725:Ganglia, Autonomic / Q000502:physiology*; D009638:Norepinephrine / Q000037:antagonists & inhibitors*; D011817:Rabbits; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission
D000109:Acetylcholine; D009638:Norepinephrine
GANGLIA, AUTONOMIC/physiology; NOREPINEPHRINE/antagonists; SYNAPSES/physiology