Inhibition of O-methyltransferase by catechol and sensitization to epinephrine.
Catechol at equimolecular concentration inhibits the inactivation of adrenaline by O-methyltransferase in vitro about 50 percent. The inhibition is probably responsible for the sensitization of smooth muscles to epinephrine by various ortho di- or triphenols.
D002396:Catechols / Q000494:pharmacology*; D004837:Epinephrine / Q000502:physiology*; D006801:Humans; D007858:Learning; D008780:Methyltransferases; D014166:Transferases
D002396:Catechols; D014166:Transferases; D008780:Methyltransferases; C034221:catechol; D004837:Epinephrine
EPINEPHRINE/physiology; PYROCATECHOL/effects; TRANSFERASES