Photodynamic inactivation of infectious nucleic acid.
Tobacco mosaic virus-infectious nucleic acid causes a color shift when combined with acridine orange, methylene blue, and safranine. A high concentration of acridine orange inactivates infectious nucleic acid even in darkness, while a mixture of nucleic acid with a low concentration of the dye must be exposed to visible light prior to inoculation for inactivation to occur.
D004396:Coloring Agents / Q000737:chemistry*; D008027:Light; D009696:Nucleic Acids / Q000737:chemistry*; D014780:Viruses / Q000737:chemistry*
D004396:Coloring Agents; D009696:Nucleic Acids
DYES/chemistry; NUCLEIC ACIDS/chemistry; VIRUSES/chemistry