title: Efficacy of oral vaccine against bacterial coldwater disease in ayu Plecoglossus altivelis.
abstract: The development of a practical vaccination method against bacterial coldwater disease (BCWD) in ayu Plecoglossus altivelis and the efficacy of oral administration of formalin-killed cells (FKCs) of Flavobacterium psychrophilum was investigated. The FKC was administrated at a dose of 0.1-0.2 g kg(-1) body weight to juvenile ayu (0.5 g body weight) every day for 2 wk or on 5 days over 2 wk. Experimental immersion challenge at 3 and 7 wk after vaccination showed significantly higher survival rates than the controls. The results show the effectiveness of oral vaccination against BCWD in ayu.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005393:Fish Diseases / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D005417:Flavobacterium / Q000276:immunology* / Q000472:pathogenicity; D016905:Gram-Negative Bacterial Infections / Q000276:immunology / Q000517:prevention & control* / Q000662:veterinary*; D036441:Osmeriformes / Q000276:immunology* / Q000382:microbiology; D014611:Vaccination / Q000662:veterinary*; D014612:Vaccines / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D014612:Vaccines