title: Inhibitory phenolic amides on lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells from Beta vulgaris var. cicla seeds.
abstract: Four phenolic compounds were isolated from Beta vulgaris L. var. cicla L. (Chenopodiaceae). These isolated compounds were identified as N-cis-feruloyl 3-O-methyldopamine (1), N-cis-feruloyl tyramine (2), N-trans-feruloyl 3-O-methyldopamine (3), N-trans-feruloyl tyramine (4), respectively, by spectroscopic analysis. The phenolic amides 1-4 exhibited modest inhibitory activity on LPS-activated nitric oxide production dose-dependently in RAW 264.7 cells.
mesh_terms: D000577:Amides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D027461:Beta vulgaris; D002460:Cell Line / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008070:Lipopolysaccharides; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis*; D010636:Phenols / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012639:Seeds
chemical_list: D000577:Amides; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; D010636:Phenols; D010936:Plant Extracts; D009569:Nitric Oxide