The effect of hexamethonium on the carotid chemoreceptor response to nicotine and cyanide.
The literature concerning the effects of ganglionic blocking agents on the chemoreceptors is reviewed. Hexamethonium blocks the respiratory response to intracarotid injections of small doses of nicotine in dogs anaesthetized with chloralose, but it does not block the response to sodium cyanide.
D000818:Animals; D002344:Carotid Body / Q000494:pharmacology*; D002628:Chemoreceptor Cells; D003486:Cyanides / Q000494:pharmacology*; D004285:Dogs; D018738:Hexamethonium; D006584:Hexamethonium Compounds / Q000494:pharmacology*; D009538:Nicotine / Q000494:pharmacology*
D003486:Cyanides; D006584:Hexamethonium Compounds; D018738:Hexamethonium; D009538:Nicotine
CAROTID BODY/pharmacology; CYANIDES/pharmacology; HEXAMETHONIUM COMPOUNDS/pharmacology; NICOTINE/pharmacology