Spinal MRI of vincristine neuropathy mimicking Guillain-Barré syndrome.
A 4.3-year-old girl with acute leukaemia, who was being treated with chemotherapy (including vincristine), developed paraplegia. Spinal MRI showed diffusely enhancing nerve roots on contrast-enhanced images. Spinal fluid analysis showed a normal protein level. Vincristine neuropathy mimicking Guillain-Barré syndrome is thought to be the cause of the MRI abnormalities.
D000971:Antineoplastic Combined Chemotherapy Protocols; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D020275:Guillain-Barre Syndrome / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D010264:Paraplegia / Q000139:chemically induced* / Q000175:diagnosis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D013126:Spinal Nerve Roots / Q000473:pathology; D013131:Spine / Q000473:pathology*; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects*
D014750:Vincristine