3D QSAR studies for the beta-tubulin binding site of microtubule-stabilizing anticancer agents (MSAAs): a pseudoreceptor model for taxanes based on the experimental structure of tubulin.
The antimitotic agent paclitaxel continues to play an important role in the cancer chemotherapy. However, its inefficacy on certain resistant cells and toxic side effects have led to the search of new taxanes with improved biological activity. By means of a pseudoreceptor modeling approach, we have developed a binding site model for a series of taxanes. It is the first 3D QSAR model derived from the experimentally determined tubulin structure obtained by electron crystallography studies. The model is able to correlate quantitatively the structural properties of the studied compounds with their biological data.
D000970:Antineoplastic Agents / Q000737:chemistry*; D001665:Binding Sites; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D021281:Quantitative Structure-Activity Relationship; D043823:Taxoids / Q000737:chemistry*; D013816:Thermodynamics; D014404:Tubulin / Q000737:chemistry*
D000970:Antineoplastic Agents; D008024:Ligands; D043823:Taxoids; D014404:Tubulin