title: Studies on the blood lipids and lipoproteins in thalassaemia and sickle cell anaemia.
abstract: In Cooley's anaemia the serum lipid fraction, determined by chemical analysis, was found to be decreased. The lipoprotein distribution by paper electrophoresis showed a characteristic pattern with abnormally low alpha(1) fraction and high concentrations of the beta fractions. There is no relationship between age and serum lipoprotein distribution. A correlation was found between the electrophoretic pattern, liver function tests, and the E/C index. Similar changes but of lesser degree were found in sickle cell anaemia. Liver damage is thought to be the probable cause of the reduced alpha(1) fraction.
mesh_terms: D000755:Anemia, Sickle Cell / Q000097:blood*; D004900:Erythroblasts; D004913:Erythrocytes, Abnormal; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D017086:beta-Thalassemia / Q000097:blood*
chemical_list: D008055:Lipids; D008074:Lipoproteins
keywords: ANEMIA, ERYTHROBLASTIC/blood; ANEMIA, SICKLE CELL/blood; LIPIDS/blood; LIPOPROTEINS/blood