X-rays affect the incorporation of 5-iododeoxyuridine into deoxyribonucleic acid.
When labeled with iodine-131, 5-iododeoxyuridine, an analogue of thymidine, is useful in estimating the effect of x-radiation on deoxyribonucleic acid metabolism. Although this compound is readily incorporated into deoxyribonucleic acid in the absence of ionizing radiation, we find that whole-body exposure to as little as 10 r will significantly inhibit its incorporation.
D001669:Biochemical Phenomena; D004247:DNA / Q000378:metabolism*; D007065:Idoxuridine; D009705:Nucleosides / Q000378:metabolism*; D009711:Nucleotides / Q000378:metabolism*; D011830:Radiation Effects; D011839:Radiation, Ionizing; D011868:Radioisotopes; D014965:X-Rays
D009705:Nucleosides; D009711:Nucleotides; D011868:Radioisotopes; D004247:DNA; D007065:Idoxuridine
DESOXYRIBONUCLEIC ACID/metabolism; NUCLEOSIDES AND NUCLEOTIDES/metabolism; RADIATION EFFECTS/experimental