The formation of an isoprenaline-like substance from adrenaline.
Intravenous injections of adrenaline, but not those of noradrenaline, caused the appearance of a substance which resembled isoprenaline in R(F) value and pharmacological activity in blood withdrawn from the lower abdominal aortae of chloralosed cats rested after acute adrenalectomy and induction of lasting block in autonomic ganglia with hexamethonium. The formation of the isoprenaline-like compound was prevented by pretreatment with pyrogallol but not by pretreatment with reserpine, cocaine, phentolamine, dibenamine, harmaline, or iproniazid. The liver proved a main site of the origin of this isoprenaline-like substance.
D000818:Animals; D002415:Cats; D003042:Cocaine; D004837:Epinephrine / Q000378:metabolism*; D018738:Hexamethonium; D007490:Iproniazid; D007545:Isoproterenol; D008099:Liver; D009638:Norepinephrine; D012110:Reserpine
D018738:Hexamethonium; D012110:Reserpine; D007490:Iproniazid; D003042:Cocaine; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine
EPINEPHRINE/metabolism