The significance of Howell-Jolly bodies and giant metamyelocytes in marrow smears.
Howell-Jolly bodies in erythroid precursors can be found in the marrow in a variety of diseases. More than 1% in the later erythroblasts is rarely found except in vitamin B(12) or folic acid deficiency states.Giant metamyelocytes are probably always the result of vitamin B(12) or folic acid deficiency. A distinction is drawn between the deficiency of, and therapeutic need for, vitamin B(12) and folic acid.
D001853:Bone Marrow; D002467:Cell Nucleus; D004908:Erythrocyte Inclusions; D005492:Folic Acid; D005494:Folic Acid Deficiency; D042381:Granulocyte Precursor Cells; D006403:Hematologic Tests; D006801:Humans; D014805:Vitamin B 12; D014806:Vitamin B 12 Deficiency; D014803:Vitamin B Complex
D014803:Vitamin B Complex; D005492:Folic Acid; D014805:Vitamin B 12
BONE MARROW; CELL NUCLEUS; FOLIC ACID/deficiency; VITAMIN B 12 DEFICIENCY