Metabolism of adrenaline after blockade of monoamine oxidase and catechol-O-methyltransferase.
Experiments in cats infused with 5 micromole of dl-adrenaline-2-C(14) showed that blockade of either monoamine oxidase or catechol-O-methyltransferase is largely compensated for by the activity of the intact enzyme system; combined blockade of both enzyme systems results in the formation of a new adrenaline catabolite and in the increased production of acidic, mainly conjugated, catabolites, the identity of which remains to be established.
D000818:Animals; D002394:Catechol O-Methyltransferase; D002415:Cats; D004837:Epinephrine / Q000378:metabolism*; D008995:Monoamine Oxidase; D008996:Monoamine Oxidase Inhibitors; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D014166:Transferases / Q000037:antagonists & inhibitors*
D008996:Monoamine Oxidase Inhibitors; D010088:Oxidoreductases; D008995:Monoamine Oxidase; D014166:Transferases; D002394:Catechol O-Methyltransferase; D004837:Epinephrine
EPINEPHRINE/metabolism; OXIDASES/antagonists; TRANSFERASES/antagonists