Specific inhibition of RHo(D) antibody by sialic acids.
Agglutination of Rh(O)(D) erythrocytes by specific antiserum was inhibited by crude and crystalline N-acetylneuraminic acid, less inhibited by its glycoyl derivative, and weakly inhibited by its degradation product, N-acetyl-mannosamine, and by D-mannose. A brain ganglioside containing neuraminic acid and a Pseudomonas polysaccharide were even more inhibitory. Inhibition was specific for anti-D sera.
D000906:Antibodies; D007518:Isoantibodies; D008358:Mannose; D019158:N-Acetylneuraminic Acid; D009438:Neuraminic Acids / Q000494:pharmacology*; D018029:Rho(D) Immune Globulin; D012794:Sialic Acids
D000906:Antibodies; D007518:Isoantibodies; D009438:Neuraminic Acids; C061961:RHO(D) antibody; D018029:Rho(D) Immune Globulin; D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid; D008358:Mannose
ANTIBODIES; NEURAMINIC ACIDS/pharmacology