Supersensitivity of salivary glands following treatment with bretylium or guanethidine.
The sensitivity of the submaxillary glands to noradrenaline was estimated once a week in cats anaesthetized with hexobarbitone. Daily subcutaneous injections of bretylium or guanethidine were found to produce a supersensitivity of the glands, similar to that caused by extirpation of the superior cervical ganglion.
D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001949:Bretylium Compounds; D002415:Cats; D006145:Guanethidine; D006591:Hexobarbital; D009638:Norepinephrine; D013363:Submandibular Gland / Q000494:pharmacology*; D017783:Superior Cervical Ganglion
D000578:Amidines; D000959:Antihypertensive Agents; D001949:Bretylium Compounds; D006591:Hexobarbital; C045166:bretylium; D009638:Norepinephrine; D006145:Guanethidine
AMIDINES/pharmacology; ANTIHYPERTENSIVE AGENTS/pharmacology; SUBMAXILLARY GLAND/pharmacology