Sparing of folinic acid by thymidine.
Thymidine, which is inactive when added alone to Pediococcus cerevisiae (Leuconostoc citrovorum) 8081, was found to increase its growth in the presence of folinic acid. The addition of thymidine increased both the sensitivity of the folinic acid assay and the total growth yield. The mechanism of the synergistic effect of thymidine is briefly discussed.
D005492:Folic Acid / Q000031:analogs & derivatives; D002955:Leucovorin; D009705:Nucleosides / Q000494:pharmacology*; D009711:Nucleotides / Q000494:pharmacology*; D013936:Thymidine
D009705:Nucleosides; D009711:Nucleotides; D005492:Folic Acid; D002955:Leucovorin; D013936:Thymidine
FOLIC ACID/related compounds; NUCLEOSIDES AND NUCLEOTIDES/pharmacology