Immunologic cross-reactions among mammalian acute phase proteins.
Crystalline rabbit Cx-reactive protein has been compared immunologically with the analogous crystalline C-reactive protein of man. Immunologic cross-reactivity has been demonstrated between the acute phase proteins of man, rabbit, and monkey. Double-diffusion reactions in agar and passive cutaneous anaphylaxis reactions in vivo both indicate that these acute phase proteins are antigenically closely similar but not identical. Guinea pigs with delayed hypersensitivity to C-reactive protein exhibit delayed skin reactions when tested with Cx-reactive protein and vice versa.
D000209:Acute-Phase Proteins; D000818:Animals; D000932:Antiemetics / Q000628:therapy*; D000941:Antigens; D001798:Blood Proteins; D002097:C-Reactive Protein; D003429:Cross Reactions; D006168:Guinea Pigs; D006801:Humans; D006968:Hypersensitivity, Delayed; D008297:Male; D010323:Passive Cutaneous Anaphylaxis; D011817:Rabbits; D012867:Skin
D000209:Acute-Phase Proteins; D000932:Antiemetics; D000941:Antigens; D001798:Blood Proteins; D002097:C-Reactive Protein
ANTIEMETICS/therapy; BLOOD PROTEINS