Lysis of brucellae by the combined action of glycine and a lysozyme-like agent from rabbit monocytes.
Ralston, Doris J. (University of California, Berkeley), B. S. Baer, and S. S. Elberg. Lysis of brucellae by the combined action of glycine and a lysozyme-like agent from rabbit monocytes. J. Bacteriol. 82:342-353. 1961.-An acid-extractable lytic material was obtained from rabbit monocytes. It acts on a substrate in the walls of brucellae and has properties similar to egg-white lysozyme. Brucella melitensis strain Rev Is is completely resistant to this agent and also to crystalline lysozyme, but when the cells are exposed to sufficient amounts of glycine, the surface is rendered susceptible to these lytic agents. Rough type Rev Is cells are more susceptible than smooth, and the virulent B. melitensis strain 6015 is most resistant.
D000818:Animals; D000891:Anti-Infective Agents, Local; D001433:Bacteriolysis; D002002:Brucella / Q000494:pharmacology*; D016923:Cell Death; D005998:Glycine / Q000494:pharmacology*; D007962:Leukocytes / Q000737:chemistry*; D009000:Monocytes; D009113:Muramidase; D011817:Rabbits
D000891:Anti-Infective Agents, Local; D009113:Muramidase; D005998:Glycine
BACTERIOLYSIS; BRUCELLA/pharmacology; GLYCINE/pharmacology; LEUKOCYTES/chemistry