Radioprotection by mitotic inhibitors and mercaptoethylamine.
In the mouse, chemical interference with cellular proliferation alters the radiosensitivity of the bone marrow, and this results in protection from otherwise lethal x-irradiation. When intestinal damage is minimized by appropriate timing and dosage, many mitotic inhibitors increase radioresistance and enhance the protective effects of mercaptoethylamine.
D000818:Animals; D001853:Bone Marrow; D002455:Cell Division / Q000494:pharmacology*; D003543:Cysteamine; D008624:Mercaptoethylamines / Q000494:pharmacology*; D051379:Mice; D011835:Radiation Protection; D014965:X-Rays
D008624:Mercaptoethylamines; D003543:Cysteamine
CELL DIVISION/pharmacology; MERCAPTOETHYLAMINES/pharmacology; RADIATION PROTECTION/experimental