Effects of 5-hydroxytryptamine on the dorsal muscle of the leech (Hirudo medicinalis).
5-Hydroxytryptamine has an inhibiting effect on the leech muscle. It reduces the contractions produced by acetylcholine or nicotine and accelerates the relaxation of the muscle when these substances are washed out. This acceleration of relaxation allows a more rapid assay of acetylcholine in this preparation.
D000109:Acetylcholine; D000818:Animals; D064131:Back Muscles; D047709:Hirudo medicinalis; D007865:Leeches; D009132:Muscles / Q000494:pharmacology*; D009538:Nicotine; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin; D009538:Nicotine; D000109:Acetylcholine
MUSCLES/pharmacology; SEROTONIN/pharmacology