The biological mechanisms of air ion action. II. Negative air ion effects on the concentration and metabolism of 5-hydroxytryptamine in the mammalian respiratory tract.
Negative air ions are shown to decrease 5-hydroxytryptamine concentrations in extirpated strips of rabbit trachea and in the respiratory tracts of living mice. An initial exposure of guinea pigs to (-) air ions causes a transient rise in urinary 5-hydroxyindoleacetic acid excretion which is not observed upon subsequent exposures. These findings are compatible with the hypothesis advanced earlier that (-) air ion effects depend on the ability of (-) ions to accelerate enzymatic oxidation of 5-hydroxytryptamine.
D000818:Animals; D006168:Guinea Pigs; D007477:Ions; D012701:Serotonin / Q000378:metabolism*; D014132:Trachea / Q000378:metabolism*
D007477:Ions; D012701:Serotonin
SEROTONIN/metabolism; TRACHEA/metabolism