Antihistaminase activity of serpentine.
Serpentine, an alkaloid of Rauwolfia serpentina, specifically potentiates histamine responses of guinea-pig ileum, uterus, and tracheal chain. It also inhibits histaminase in vitro. Its antihistaminase activity is equivalent to that of aminoguanidine.
D000470:Alkaloids; D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors*; D006146:Guanidines; D006168:Guinea Pigs; D006632:Histamine; D007082:Ileum; D011926:Rauwolfia / Q000494:pharmacology*; D014132:Trachea
D000470:Alkaloids; D006146:Guanidines; D006632:Histamine; D006631:Amine Oxidase (Copper-Containing); C004479:pimagedine
HISTAMINASE/antagonists; RAUWOLFIA/pharmacology