Repression of ornithine transcarbamylase protein formation by arginine.
Arginine-repressed cells of Escherichia coli W do not form a protein immunologically related to ornithine transcarbamylase. This was determined by lack of cross-reactivity of repressed cell extracts with rabbit antisera prepared against purified ornithine transcarbamylase. The results indicate that arginine acts by blocking the synthesis of the entire enzyme-protein.
D001120:Arginine / Q000494:pharmacology*; D004926:Escherichia coli / Q000378:metabolism*; D009952:Ornithine; D009954:Ornithine Carbamoyltransferase; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism*; D014166:Transferases / Q000378:metabolism*
D011506:Proteins; D001120:Arginine; D009952:Ornithine; D014166:Transferases; D009954:Ornithine Carbamoyltransferase
ARGININE/pharmacology; ESCHERICHIA COLI/metabolism; PROTEINS/metabolism; TRANSFERASES/metabolism