Inhibiting effect of tobacco smoke on some crystalline enzymes.
Tobacco smoke absorbed in phosphate buffer at neutral pH inhibits irreversibly the enzymes rabbit muscle glyceraldehyde-3-phosphate dehydrogenase and yeast alcohol dehydrogenase, whereas lactic dehydrogenase and glutamic dehydrogenase are not inhibited. A transient inhibition of beef liver catalase occurs. Indirect evidence suggests that the observed enzyme inhibition is caused by peroxides present in the smoke.
D000818:Animals; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D006863:Hydrogen-Ion Concentration; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D011817:Rabbits; D012906:Smoke; D014026:Nicotiana
D012906:Smoke; D010088:Oxidoreductases; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases
DEHYDROGENASES/antagonists; TOBACCO