Intravenous nutrition. A clinical evaluation of a 50 per cent dextrose in water solution, containing 1 mg. of hydrocortisone per 100 ml.
A 50 per cent dextrose in water solution, containing 1 mg. of hydrocortisone per 100 ml., was used successfully in 70 patients for intravenous nutritional maintenance and repletion. There were no adverse systemic effects during or following 216 infusions. The only undesirable local reaction was the rare occurrence of pain in the arm when the concentrated solutions were given too rapidly. Glycosuria was minimal if the infusion rate did not exceed 0.85 gm. of glucose per kilogram of body weight per hour, particularly if 50 units of insulin were added to each 550 ml. bottle of 50 per cent dextrose. In patients without significantly elevated serum potassium content, 30 mEq. of potassium chloride, acetate or phosphate was added to each bottle to prevent hypokalemia.Preliminary observations suggest that this new solution may be given safely intravenously, without need for cutdowns or plastic catheters, if the needle is carefully inserted and well immobilized in the arm vein and the duration of the infusion is not too prolonged. Further studies on the effect of such high caloric supplementation plus protein hydrolysates in parenteral nutritional repletion and maintenance are indicated.
D000137:Acid-Base Imbalance; D005947:Glucose; D006801:Humans; D006854:Hydrocortisone / Q000628:therapy*; D007263:Infusions, Parenteral; D007328:Insulin; D010710:Phosphates; D012996:Solutions; D014882:Water-Electrolyte Balance / Q000494:pharmacology*; D014883:Water-Electrolyte Imbalance
D007328:Insulin; D010710:Phosphates; D012996:Solutions; D005947:Glucose; D006854:Hydrocortisone
GLUCOSE; HYDROCORTISONE/therapy; INFUSIONS, PARENTERAL; WATER-ELECTROLYTE BALANCE/pharmacology