Some effects of corticosteroids on the metabolism of histamine and 5-hydroxytryptamine in the rat.
Daily intramuscular injections of cortisone, prednisolone, triamcinolone, fludrocortisone and 2-methylfludrocortisone reduced the histidine decarboxylase activity of the rat liver, but increased the enzyme activity of the pyloric stomach. Injections of histamine liberators or exposure to cold produced similar changes. After adrenalectomy, the histidine decarboxylase activities of the liver and pyloric stomach were unaltered, but the histaminase activity of the ileum was reduced. The 5-hydroxytryptophan decarboxylase activities of rat liver and kidney were not altered by treatment with corticosteroids.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000315:Adrenalectomy; D000818:Animals; D001142:Aromatic-L-Amino-Acid Decarboxylases; D002317:Cardiovascular Agents; D003348:Cortisone; D003879:Dermatologic Agents; D005438:Fludrocortisone; D005938:Glucocorticoids; D006632:Histamine / Q000378:metabolism*; D007082:Ileum; D007668:Kidney; D008099:Liver; D011239:Prednisolone; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D014221:Triamcinolone
D000305:Adrenal Cortex Hormones; D002317:Cardiovascular Agents; D003879:Dermatologic Agents; D005938:Glucocorticoids; D014221:Triamcinolone; D012701:Serotonin; D006632:Histamine; D011239:Prednisolone; D001142:Aromatic-L-Amino-Acid Decarboxylases; D005438:Fludrocortisone; D003348:Cortisone
ADRENAL CORTEX HORMONES/pharmacology; HISTAMINE/metabolism; SEROTONIN/metabolism