Polycythaemia vera and Christmas disease with slightly prolonged prothrombin time.
A family is reported in which Christmas disease in one member and polycythaemia in another were associated with prolongations of the one-stage prothrombin time of the factor-VII deficiency type. Changes in the prothrombin time were present in the siblings of the case of Christmas disease and in a number of unrelated cases of polycythaemia vera. The use of "mixing procedures" did not reveal any significant mutual correction of the changes in prothrombin time.
D006467:Hemophilia A / Q000235:genetics*; D002836:Hemophilia B; D006801:Humans; D011087:Polycythemia Vera / Q000235:genetics*; D011517:Prothrombin Time
HEMOPHILIA/genetics; POLYCYTHEMIA VERA/genetics