Rifomycin. XIII. Fermentation and production of rifomycin complex.
Rifomycin complex, a mixture of at least five different antibiotic principles, has been produced by submerged fermentation procedures in the laboratory and on pilot plant scale, using a semisynthetic medium. Difficulties were met with, due to the heterogeneity of the antibiotic principles. Mutation work led to the isolation of a strain that produced fractions C and D in greater amounts.
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D005285:Fermentation; D012294:Rifamycins; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D012294:Rifamycins; C023808:rifamycin SV
ANTIBIOTICS/metabolism; STREPTOMYCES/metabolism