Mechanism of action of oral antidiabetic drugs.
The fall in blood sugar with carbutamide (BZ55) 24 hr. after the maintenance dose of insulin (28.1%+/-2.9 s.e) in rabbits made severely diabetic with alloxan was significantly different from the change in the blood sugar with the same drug given 72 hr. (6.8%+/-2.0) or distilled water given 24 hr. (7.7%+/-1.3) respectively after the last dose of insulin. It is postulated that the drug acts by liberating bound insulin in the plasma.
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose; D002271:Carbutamide / Q000494:pharmacology*; D003920:Diabetes Mellitus; D006801:Humans; D007004:Hypoglycemic Agents; D007328:Insulin; D011817:Rabbits
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D000496:Alloxan; D002271:Carbutamide
CARBUTAMIDE/pharmacology