A study of potential histidine decarboxylase inhibitors.
A series of compounds has been examined for ability to inhibit histidine decarboxylase. Histidine analogues having substituents in the imidazole ring showed a wide variation in potency, but these were all much less active than alpha-methyldopa [beta-(3,4-dihydroxyphenyl)-alpha-methylalanine], the most potent known inhibitor of histidine decarboxylase. Some tentative conclusions are drawn regarding the relationship between chemical structure and inhibitory activity.
D000621:Aminoisobutyric Acids; D006639:Histidine; D006640:Histidine Decarboxylase; D007093:Imidazoles / Q000494:pharmacology*; D008190:Lyases / Q000037:antagonists & inhibitors*; D008750:Methyldopa
D000621:Aminoisobutyric Acids; D007093:Imidazoles; C100049:2-aminoisobutyric acid; D006639:Histidine; D008750:Methyldopa; C029899:imidazole; D008190:Lyases; D006640:Histidine Decarboxylase
DESMOLASES/antagonists; IMIDAZOLES/pharmacology