Rifomycin. XIV. Production of rifomycin B.
The production of a fraction of the rifomycin complex (rifomycin B) by Streptomyces mediterranei has been described. Both qualitative and quantitative aspects of the fermentation are determined by suitable agitation-aeration parameters. In addition to conventional nutrient ingredients, the presence of some of the barbituric acid derivatives was found to be essential for rifomycin B production. An attempt was made to explain the mode of action of these compounds.
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D005285:Fermentation; D012294:Rifamycins; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D012294:Rifamycins; C033974:rifamycin B; C023808:rifamycin SV
ANTIBIOTICS/metabolism; STREPTOMYCES/metabolism