Parkinson's syndrome, depression and imipramine. A preliminary report.
Patients with Parkinson's syndrome whose major symptoms are akinesis, rigidity, inertia, depression, irritability and failure of adaptation rather than tremor appear to benefit in a global way from therapy with imipramine. Patients without much over-all functional impairment do not show this improvement. The hypothesis is offered that motivation to move and ability to move are perhaps neurologically as well as psychologically related functions.
D003863:Depression / Q000628:therapy*; D003866:Depressive Disorder; D006801:Humans; D007099:Imipramine; D007508:Irritable Mood; D009042:Motivation; D009127:Muscle Rigidity; D010300:Parkinson Disease / Q000150:complications*; D011600:Psychopharmacology
D007099:Imipramine
DEPRESSION/therapy; PARALYSIS AGITANS/complications; PSYCHOPHARMACOLOGY