Neuromuscular blockade by streptomycin and dihydrostreptomycin.
Both streptomycin and dihydrostreptomycin in large doses produced neuromuscular blockade in different types of skeletal nerve-muscle preparations. Streptomycin had a quicker, more marked and a longer-lasting action than dihydrostreptomycin. Neostigmine reversed a partial block of streptomycin, but a complete neuromuscular block remained unaffected. Calcium ions antagonized the neuromuscular block of streptomycin rapidly but incompletely.
D004096:Dihydrostreptomycin Sulfate; D006801:Humans; D009388:Neostigmine; D019148:Neuromuscular Blockade; D009469:Neuromuscular Junction / Q000494:pharmacology*; D013307:Streptomycin / Q000031:analogs & derivatives / Q000494:pharmacology*
D009388:Neostigmine; D004096:Dihydrostreptomycin Sulfate; D013307:Streptomycin
MYONEURAL JUNCTION/pharmacology; STREPTOMYCIN/pharmacology; STREPTOMYCIN/related compounds