Inhibition of brain glutamic acid decarboxylase by phenylalanine, valine, and leucine derivatives: a suggestion concerning the etiology of the neurological defect in phenylketonuria and branched-chain ketonuria.
D000596:Amino Acids / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D005968:Glutamate Decarboxylase; D006801:Humans; D008607:Intellectual Disability / Q000209:etiology*; D007662:Ketosis; D007930:Leucine; D008190:Lyases / Q000037:antagonists & inhibitors*; D008375:Maple Syrup Urine Disease; D008659:Metabolic Diseases / Q000209:etiology*; D010649:Phenylalanine; D010661:Phenylketonurias / Q000209:etiology*; D014633:Valine
D000596:Amino Acids; D010649:Phenylalanine; D008190:Lyases; D005968:Glutamate Decarboxylase; D007930:Leucine; D014633:Valine
AMINO ACIDS/pharmacology; BRAIN/metabolism; DESMOLASES/antagonists; MENTAL DEFICIENCY/etiology; METABOLIC DISEASES/etiology; PHENYLPYRUVIC OLIGOPHRENIA/etiology