Rapid development of drug-resistant mutants of poliovirus.
Guanidine hydrochloride is a potent inhibitor of poliovirus synthesis in cell culture. However, the viral progeny which do grow in the presence of guani-dine may become approximately 10,000 times more resistant to the drug. The phenomenon of drug resistance poses yet another problem in the search for a satisfactory viral chemotherapeutic agent.
D000578:Amidines / Q000494:pharmacology*; D011051:Poliomyelitis; D017955:Poliovirus / Q000494:pharmacology*
D000578:Amidines
AMIDINES/pharmacology; POLIOMYELITIS VIRUSES/pharmacology