Chronic effect of tetanus toxin applied locally to the cerebral cortex of the dog.
Tetanus toxin injected into the cortex produces convulsions, neurological disability, and a strychnine-like discharging focus, appearing after a minimal latency of 2 days and lasting more than a month. Such a focus, apparently caused by a blockade of inhibitory synapses, does not demonstrate any major damage in microscopic studies.
D000818:Animals; D000992:Antitoxins / Q000494:pharmacology*; D001826:Body Fluids; D002540:Cerebral Cortex / Q000494:pharmacology*; D004285:Dogs; D012640:Seizures; D013744:Tetanus Toxin; D014118:Toxins, Biological / Q000494:pharmacology*
D000992:Antitoxins; D013744:Tetanus Toxin; D014118:Toxins, Biological
CEREBRAL CORTEX/pharmacology; CONVULSIONS/experimental; TOXINS AND ANTITOXINS/pharmacology