Action of 1,1,dichloro-2-p-chlorophenyl-2-o-chlorophenylethane on dog adrenal cortex.
A single intravenous injection of op'DDD (1,1,dichloro-2-p-chlorophenyl-2-o-chlorophenylethane) has an acute effect on the adrenal cortex of the dog. Within 2 hours after intravenous injection of the drug, there is a decrease in the in vitro response of the adrenal cortex to stimulation by adrenocorticotrophic hormone and an inhibition of glucose-6-phosphate dehydrogenase activity. The inhibition of glucose-6-phosphate dehydrogenase activity might explain the effect of op'DDD on corticosteroid production.
D000302:Adrenal Cortex / Q000494:pharmacology*; D000305:Adrenal Cortex Hormones; D000324:Adrenocorticotropic Hormone; D000818:Animals; D003634:DDT / Q000031:analogs & derivatives; D004285:Dogs; D005954:Glucosephosphate Dehydrogenase; D010084:Oxidation-Reduction
D000305:Adrenal Cortex Hormones; D000324:Adrenocorticotropic Hormone; D003634:DDT; D005954:Glucosephosphate Dehydrogenase
ADRENAL CORTEX/pharmacology; DDT/related compounds