Effects of chronia excess salt ingestion. Evidence that genetic factors play an important role in susceptibility to experimental hypertension.
Using the genetic technique of selective inbreeding, it has been possible to quickly develop two statistically separable populations from one unselected strain of Sprague-Dawley rats. One of these is very sensitive, the other very resistant, to the development of experimental hypertension from a high salt diet. It was suggested that similar genetic factors operate in man.
D000818:Animals; D004032:Diet; D004198:Disease Susceptibility; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012965:Sodium Chloride / Q000633:toxicity*
D012965:Sodium Chloride
HYPERTENSION/etiology; SODIUM CHLORIDE/toxicology