Glucose-6-phosphate dehydrogenase and detoxification of hydrogen peroxide in human erythrocytes.
Human erythrocytes with deficient glucose-6-phosphate dehydrogenase levels are unable to maintain their levels of reduced glutathione in the presence of low-level, steady-state concentrations of hydrogen peroxide. This finding has bearing on the biochemical mechanisms of drug-induced hemolytic anemia.
D004912:Erythrocytes; D005954:Glucosephosphate Dehydrogenase; D005955:Glucosephosphate Dehydrogenase Deficiency; D005978:Glutathione; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood*; D010088:Oxidoreductases / Q000097:blood*
D006861:Hydrogen Peroxide; D010088:Oxidoreductases; D005954:Glucosephosphate Dehydrogenase; D005978:Glutathione
DEHYDROGENASES/blood; ERYTHROCYTES; HYDROGEN PEROXIDE/blood