Unsaturated amino acids. V. Microbiological properties of some halogenated olefinic amino acids.
Shapira, Jacob (Department of Chemistry, Florida State University, Tallahassee) and Karl Dittmer. Unsaturated amino acids. V. Microbiological properties of some halogenated olefinic amino acids. J. Bacteriol. 82:640-647. 1961.-It has been shown previously that several amino acid analogues containing unsaturated linkages were inhibitors of the growth of Escherichia coli and Saccharomyces cerevisiae. This paper reports the results obtained when a series of unsaturated halogen-containing amino acids was examined. The cis isomer of omega-chloroallylglycine showed the greatest toxicity yet found in this series of unsaturated amino acids toward E. coli, whereas the trans-isomer was usually far less toxic. The major effect of cis-omega-chloroallylglycine in E. coli appeared to be to extend the lag phase before the normal rate of growth began. A wide variety of amino acids was capable of partially or completely preventing the toxicity of low levels of these compounds. At higher levels, relatively few amino acids (primarily valine, leucine, and glutamic acid) were effective. In E. coli, cis-omega-chloroallylglycine showed an unusual [Formula: see text] relationship with both glutamic acid and valine over a wide range in concentration.
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D000596:Amino Acids / Q000494:pharmacology*; D004926:Escherichia coli / Q000494:pharmacology*; D005431:Florida; D007536:Isomerism; D007930:Leucine; D014633:Valine; D015003:Yeasts / Q000494:pharmacology*
D000596:Amino Acids; D007930:Leucine; D014633:Valine
AMINO ACIDS/pharmacology; ESCHERICHIA COLI/pharmacology; YEASTS/pharmacology