Autoimmune response in rabbits injected with rat and rabbit liver ribosomes.
Autoimmune hemolytic anemia and leukopenia, circulating autoantibodies for erythrocytes, leukocytes, and ribosomes; pathological changes in liver, spleen, heart, brain, and kidneys were produced in rabbits injected with rat or rabbit liver ribosomes. The hematologic and pathologic changes were reproduced by injection of anti-ribosomal serum into normal rabbits. The autoantibody specificity was related primarily to nucleotides and nucleosides.
M C
MC
DODD
N J
NJ
BIGLEY
V B
VB
GEYER
F W
FW
McCOY
H E
HE
WILSON
D000818:Animals; D001323:Autoantibodies; D015551:Autoimmunity; D004912:Erythrocytes; D007109:Immunity; D008099:Liver / Q000737:chemistry*; D009698:Nucleoproteins / Q000494:pharmacology*; D009711:Nucleotides; D011817:Rabbits; D051381:Rats; D012270:Ribosomes; D013154:Spleen
D001323:Autoantibodies; D009698:Nucleoproteins; D009711:Nucleotides
IMMUNITY; LIVER/chemistry; NUCLEOPROTEINS/pharmacology