Effects of bacterial endotoxin on rabbit platelets. I. Platelet aggregation and release of platelet factors in vitro.
Incubation of platelet-rich rabbit plasma with E. coli endotoxin at 37 degrees C results in platelet aggregation and transfer of platelet 5-hydroxytryptamine to plasma. Release of 5HT is influenced by dose of endotoxin, type of anticoagulant, and temperature of incubation. A heat-labile plasma factor is necessary for the platelet-endotoxin interaction. Additional studies have shown that incubation of endotoxin with platelet-rich rabbit plasma also results in release of platelet phospholipid and bactericidins active against B. subtilis.
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D000818:Animals; D000992:Antitoxins; D001792:Blood Platelets; D004731:Endotoxins; D004926:Escherichia coli; D006801:Humans; D066298:In Vitro Techniques; D010949:Plasma; D010974:Platelet Aggregation; D011817:Rabbits; D012701:Serotonin; D014118:Toxins, Biological
D000992:Antitoxins; D004731:Endotoxins; D014118:Toxins, Biological; D012701:Serotonin
BLOOD PLATELETS; ESCHERICHIA COLI; TOXINS AND ANTITOXINS