Hypothalamic control of feeding and self-stimulation.
Hypothalamic sites which control feeding exert a corresponding control over lateral hypothalamic self-stimulation. This was demonstrated in rats bearing four, intrahypothalamic electrode-cannulas for electrical stimulation or chemical injection. Self-stimulation of the lateral hypothalamus was inhibited by ventromedial excitation or by excessive feeding. Both self-stimulation and feeding were accelerated (disinhibited) by ventromedial ablation or anesthetization. Thus food acts via the ventromedial hypothalamus to inhibit not only feeding, but also lateral hypothalamic self-stimulation.
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HOEBEL
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TEITELBAUM
D000818:Animals; D001519:Behavior; D004558:Electric Stimulation; D005502:Food; D007031:Hypothalamus / Q000502:physiology*; D051381:Rats
BEHAVIOR; HYPOTHALAMUS/physiology