The role of antibody, delayed hypersensitivity, and interferon production in recovery of guinea pigs from primary infection with vaccinia virus.
In guinea pigs, methotrexate and x-radiation have been employed to block the development of delayed hypersensitivity and of antibody to vaccinia virus during experimental infection. Animals whose specific responses were blocked by x-radiation and methotrexate recovered from vaccinia virus infection as rapidly as non-treated control animals suggesting that these responses were not essential in recovery of the infected animals. A virus-inhibiting substance with the properties of interferon was present in skin of untreated and methotrexate- and x-radiation-treated animals infected with vaccinia virus.
R M
RM
FRIEDMAN
BARONS
C E
CE
BUCKLER
R I
RI
STEINMULLER
D000818:Animals; D000906:Antibodies; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D007372:Interferons; D012867:Skin; D014615:Vaccinia / Q000276:immunology*; D014616:Vaccinia virus; D014780:Viruses
D000906:Antibodies; D007372:Interferons
ANTIBODIES; VACCINIA/immunology; VIRUSES