Inhibitory effect of thiopentone on the pyruvic dehydrogenase in brain. Reversibility of action by thiamine pyrophosphate and lipoic acid.
FAHMY
A R
AR
IBRAHIM
H H
HH
TALAAT
M
M
D001921:Brain / Q000378:metabolism*; D006801:Humans; D009448:Neurochemistry; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D011773:Pyruvates / Q000378:metabolism*; D013835:Thiamine Pyrophosphate / Q000494:pharmacology*; D008063:Thioctic Acid / Q000494:pharmacology*; D013874:Thiopental / Q000494:pharmacology*
D011773:Pyruvates; D008063:Thioctic Acid; D010088:Oxidoreductases; D013874:Thiopental; D013835:Thiamine Pyrophosphate
BRAIN/metabolism; COCARBOXYLASE/pharmacology; DEHYDROGENASES/antagonists; LIPOIC ACID/pharmacology; PYRUVATES/metabolism; THIOPENTAL/pharmacology