Biosynthesis of cephalosporin C.
The superiority of d-methionine over l-methionine for stimulation of cephalosporin C synthesis in a crude medium was confirmed. The optimal level of dl-methionine was 0.5%. Methionine stimulates growth slightly but this is not thought to be the cause of the marked stimulation of antibiotic synthesis. Of a large number of sulfur compounds tested, only dl-methionine-dl-sulfoxide and S-methyl-l-cysteine showed considerable methionine-replacing activity. Lysine and alpha-aminoadipic acid were inactive.
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D015074:2-Aminoadipic Acid; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002511:Cephalosporins; D003545:Cysteine / Q000031:analogs & derivatives; D008239:Lysine; D008715:Methionine
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D015074:2-Aminoadipic Acid; C025163:cephalosporin C; D008715:Methionine; D008239:Lysine; D003545:Cysteine; C017507:mecysteine
ANTIBIOTICS/metabolism