Excretion of antibiotics in bile.
The excretion of antibiotics in the bile of rats has been studied. Penicillins, including derivatives of 6-aminopenicillanic acid, are rapidly excreted, reabsorbed and re-excreted, in high concentration, whereas streptomycin, neomycin, paramomycin and chloramphenicol reach lower levels in the bile than in the plasma. p-Aminobenzylpenicillin and D(-)-6-(alpha-amino-alpha-phenylacetamido)penicillanic acid, both of which are bactericidal to Salmonellae and other coliforms, produce higher concentrations in the bile than benzylpenicillin (penicillin G). This may be of therapeutic importance.
HARRISON
P M
PM
STEWART
G T
GT
D000667:Ampicillin; D000818:Animals; D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D001646:Bile / Q000378:metabolism*; D001692:Biological Transport; D001826:Body Fluids; D002701:Chloramphenicol; D009355:Neomycin; D010303:Paromomycin; D010397:Penicillanic Acid / Q000031:analogs & derivatives; D010400:Penicillin G; D010406:Penicillins / Q000378:metabolism*; D051381:Rats; D013307:Streptomycin
D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D010406:Penicillins; D010303:Paromomycin; D002701:Chloramphenicol; D000667:Ampicillin; D010397:Penicillanic Acid; D009355:Neomycin; D010400:Penicillin G; C004408:aminopenicillanic acid; D013307:Streptomycin
BILE/metabolism; PENICILLIN/metabolism