Diuresis in rats: effects of sympathomimetic and sympathetic blocking agents.
Dopamine and tyramine possess diuretic properties resembling but weaker than those of noradrenaline in the rat. These three amines produce a relatively smaller loss of sodium than does adrenaline. Bretylium shows a diuretic action which is apparently associated with its sympathomimetic properties and which is antagonized by phenoxybenzamine. However, bretylium causes a relatively greater loss of potassium and chloride than do the sympathomimetic amines. A slight antidiuretic action is shown by bretylium after its diuretic effect has subsided and a similar effect is produced by BW 172C58, which has relatively weak sympathomimetic properties. In contrast to these adrenergic neurone blocking agents, phenoxybenzamine and a ganglion blocking agent (pentacynium) show powerful antidiuretic effects. These observations are consistent with the view that the adrenal medulla has an important role in facilitating water diuresis in rats.
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D018663:Adrenergic Agents; D000588:Amines; D000818:Animals; D001949:Bretylium Compounds; D004231:Diuresis; D004232:Diuretics; D004298:Dopamine; D007668:Kidney / Q000494:pharmacology*; D009474:Neurons; D009638:Norepinephrine; D010643:Phenoxybenzamine; D051381:Rats; D013565:Sympatholytics / Q000494:pharmacology*; D013566:Sympathomimetics / Q000494:pharmacology*; D014439:Tyramine
D018663:Adrenergic Agents; D000588:Amines; D001949:Bretylium Compounds; D004232:Diuretics; D013565:Sympatholytics; D013566:Sympathomimetics; D010643:Phenoxybenzamine; C045166:bretylium; D004298:Dopamine; D009638:Norepinephrine; D014439:Tyramine
KIDNEY/pharmacology; SYMPATHOLYTICS/pharmacology; SYMPATHOMIMETICS/pharmacology