5-Hydroxytryptamine and transmission in sympathetic ganglia.
Rat stellate ganglia were isolated and maintained in a moist chamber in which they were intermittently immersed in physiological saline containing low concentrations of the compound under investigation. 5-Hydroxytryptamine (serotonin) in concentrations as low as 1.3x10(-6) M reduced reversibly the threshold and increased the amplitude of responses to preganglionic stimulation. Certain antagonists of 5-hydroxytryptamine depressed reversibly the postsynaptic responses. Experiments in vivo supported this finding. It is suggested that 5-hydroxytryptamine facilitates transmission in the sympathetic ganglia of rats.
HERTZLER
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D000818:Animals; D005725:Ganglia, Autonomic / Q000494:pharmacology*; D005728:Ganglia, Sympathetic; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*
D012701:Serotonin
GANGLIA, AUTONOMIC/pharmacology; SEROTONIN/pharmacology