Isolation from rat brain of a metabolic product, desmethylimipramine, that mediates the antidepressant activity of imipramine (Tofranil).
GILLETTE
J R
JR
DINGELL
J V
JV
SULSER
F
F
KUNTZMAN
R
R
BRODIE
B B
BB
D000818:Animals; D000928:Antidepressive Agents; D001921:Brain / Q000378:metabolism*; D003891:Desipramine; D007099:Imipramine / Q000494:pharmacology*; D009448:Neurochemistry; D051381:Rats
D000928:Antidepressive Agents; D007099:Imipramine; D003891:Desipramine
BRAIN/metabolism; IMIPRAMINE/pharmacology