Enzymatic activities associated with clotting of fibrinogen by staphylocoagulase and coagulase-reacting factor and their inhibition by disopropylfluophosphate.
Drummond, Margaret C. (Emory University, Atlanta, Ga.) and Morris Tager. Enzymatic activities associated with clotting of fibrinogen by staphylocoagulase and coagulase-reacting factor and their inhibition by diisopropylfluorophosphate. J. Bacteriol. 83:975-980. 1962.-The chemical mechanism of fibrinogen clotting by staphylocoagulase and its plasma factor (CRF) involves a preliminary stage of proteolysis, analogous to that found in thrombin-catalyzed fibrinogen clotting. Coagulase-CRF also exhibits N-alpha-toluene-p-sulfonyl-l-arginine methyl esterase activity in addition to its fibrinogen-clotting and proteolytic activities. These enzymatic activities have been further studied by their responses to certain enzyme inhibitors, and from the standpoint of their possible interrelationships.
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TAGER
D001120:Arginine; D001777:Blood Coagulation; D003030:Coagulase; D004798:Enzymes; D005340:Fibrinogen; D005459:Fluorides / Q000494:pharmacology*; D010710:Phosphates / Q000494:pharmacology*; D013210:Staphylococcus / Q000378:metabolism*; D013917:Thrombin
D003030:Coagulase; D004798:Enzymes; D010710:Phosphates; D005340:Fibrinogen; D001120:Arginine; D013917:Thrombin; D005459:Fluorides
ENZYMES; FIBRINOGEN; FLUORIDES/pharmacology; PHOSPHATES/pharmacology; STAPHYLOCOCCUS/metabolism