Circadian rhythm in the in vitro response of mouse adrenal to adrenocorticotropic hormone.
Adrenal corticosterone production resulting from adrenocorticotropic hormone (ACTH) stimulation in vitro depends upon the time of gland removal. This rhythm in adrenal reactivity to ACTH is out of phase with the corticosterone rhythm in serum of the mice used as donors of adrenals. The responsiveness of the gland to exogenous ACTH is highest when serum corticosterone levels are lowest.
D000305:Adrenal Cortex Hormones / Q000502:physiology*; D000311:Adrenal Glands; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D002940:Circadian Rhythm; D003345:Corticosterone; D066298:In Vitro Techniques; D051379:Mice; D010507:Periodicity
D000305:Adrenal Cortex Hormones; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone
ADRENAL CORTEX HORMONES/physiology; CORTICOTROPIN/pharmacology; PERIODICITY