Antigenicity of polypeptides: immunological unresponsiveness to copolymers of gamma-amino acids.
Immunological tolerance toward three synthetic random copolymers of the alpha-amino acids, glutamic, lysine, alanine, and tyrosine, was produced by a single injection of the polymers into newborn rabbits. The tolerant state could be extended by an additional intravenous injection of antigen. Repeated injections of the polymer in adjuvant mixture could "break" the tolerant state.
D000276:Adjuvants, Immunologic; D000409:Alanine; D000596:Amino Acids; D000818:Animals; D000941:Antigens; D005720:Gamma Rays; D005971:Glutamates; D008239:Lysine; D010455:Peptides; D011108:Polymers; D011233:Precipitin Tests; D011817:Rabbits; D014443:Tyrosine
D000276:Adjuvants, Immunologic; D000596:Amino Acids; D000941:Antigens; D005971:Glutamates; D010455:Peptides; D011108:Polymers; D014443:Tyrosine; D008239:Lysine; D000409:Alanine
ANTIGENS; GLUTAMATES