Properties of guinea pig 7S antibodies. II. Identification of antibodies involved in passive cutaneous and systemic anaphylaxis.
Guinea pig 7Sgamma(1) antibodies were demonstrated to mediate passive systemic or cutaneous anaphylaxis; guinea pig 7Sgamma(2) antibodies were unable to mediate these reactions. Gamma-2 antibodies specifically inhibited passive cutaneous anaphylactic reactions provoked by gamma-1 antibodies by competing for antigen. However, gamma-2 antibodies were unable to inhibit passive cutaneous sensitization of guinea pigs by a heterologous antibody system. Guinea pig 7Sgamma(2) antibodies appear to lack receptors for fixation to guinea pig tissues and do not compete with sensitizing antibody for receptor sites.
D000707:Anaphylaxis; D000818:Animals; D000906:Antibodies; D000941:Antigens; D006168:Guinea Pigs; D010323:Passive Cutaneous Anaphylaxis; D005719:gamma-Globulins
D000906:Antibodies; D000941:Antigens; D005719:gamma-Globulins
ANAPHYLAXIS; ANTIBODIES; GAMMA GLOBULIN