Microbiological degradation of tetracyclines.
Meyers, Edward (Squibb Institute for Medical Research, New Brunswick, N.J.) and Dorothy A. Smith. Microbiological degradation of tetracyclines. J. Bacteriol. 84:797-802. 1962-The degradation of tetracyclines by an ascomycete, Xylaria digitata, was demonstrated. Washedcell suspensions were capable of degrading tetracycline, 5-hydroxytetracycline, 7-chlortetracycline, 7-chlor-6-demethyltetracycline, 2-acetyl-2-decarboxamido-5-hydroxytetracycline, and 12-alpha-deoxytetracycline. The influence of environmental conditions upon the degradation of tetracycline was investigated. A nonantibacterial, nonfluorescent product was located from the degradation of (14)C 5-hydroxytetracycline. Evidence indicated that neither the A nor D ring of 5-hydroxytetracycline is attacked. Acetone powders, lyophilized powders, and cell-free extracts exhibited a relatively limited substrate specificity compared to the washed cells.
D000900:Anti-Bacterial Agents; D001203:Ascomycota; D002751:Chlortetracycline; D003707:Demeclocycline; D006801:Humans; D010118:Oxytetracycline; D013752:Tetracycline; D013754:Tetracyclines
D000900:Anti-Bacterial Agents; D013754:Tetracyclines; D003707:Demeclocycline; D013752:Tetracycline; D002751:Chlortetracycline; D010118:Oxytetracycline
ASCOMYCETES; CHLORTETRACYCLINE; DEMETHYLCHLORTETRACYCLINE; TETRACYCLINE