Equilibration of isoagglutinins of human group O serum.
Cross-reactive antibodies are shown to be responsibile for the difference in final levels of agglutination reached after dissociation of a centrifuged group O serum-erythrocyte mixture as compared with duplicate mixtures allowed toaggregate freely. This difference is seen only with certain group O sera, it is independent of complement, and it may be eliminated by absorption of the serum with A or B erythrocytes. The phenomenon is most likely the result of steric inhibition of smaller, cross-reactive antibodies in the aggregative system.
D000906:Antibodies; D001789:Blood Group Antigens; D003429:Cross Reactions; D004912:Erythrocytes; D006801:Humans
D000906:Antibodies; D001789:Blood Group Antigens
ANTIBODIES; BLOOD GROUPS