Decarboxylase inhibitors affect convulsion thresholds to hexafluorodiethyl ether.
Alpha-methyl dihydroxyphenylalanine (alpha-MeDOPA) and alpha-methyl meta-tyrosine (alpha-MMT) do not lower significantly the convulsion thresholds to hexafluorodiethyl ether in the mouse, whereas reserpine and tetrabenazine produce marked lowering of these thresholds. Other workers have shown that alpha-MeDOPA and alpha-MMT decrease brain norepinephrine concentrations much more than brain 5-hydroxytryptamine concentrations, while reserpine and tetrabenazine decrease the brain level of these two amines in a parallel fashion. Thus, the fact that alpha-MeDOPA and alpha-MMT, even in very large doses, do not lower convulsion thresholds and in some cases raise them suggests that the decline in 5-hydroxytryptamine may be implicated in the lowering of convulsion thresholds produced by reserpine and other, similar agents.
D000588:Amines; D000818:Animals; D001921:Brain; D002262:Carboxy-Lyases; D004295:Dihydroxyphenylalanine; D004986:Ether / Q000031:analogs & derivatives; D008190:Lyases / Q000494:pharmacology*; D001523:Mental Disorders; D051379:Mice; D009638:Norepinephrine; D012640:Seizures; D012701:Serotonin
D000588:Amines; D004986:Ether; D012701:Serotonin; D004295:Dihydroxyphenylalanine; D008190:Lyases; D002262:Carboxy-Lyases; D009638:Norepinephrine
DESMOLASES/pharmacology; ETHER, ETHYL/related compounds