Intestinal transport of selenium-75 selenomethionine.
When measured simultaneously, selenium-75 selenomethionine accumulated identically with sulfur-35 methionine across everted hamster intestinal sacs in the presence of carrier methionine. The apparent K(m) for L-methionine transport was 0.8 x 10(-3) M, as calculated from the beta emissions of S(35)-methionine or the gamma emissions of Se(75)-selenomethionine. Absorption of Se(75)-selenomethionine from the gastrointestinal tract of man also occurred, with peak blood levels being reached in about 3 hours. Because of the 122-day half-life of selenium-75 and its multiple gamma emissions, Se(75)-selenomethionine may serve as a tool in evaluating amino-acid absorption.
D000596:Amino Acids; D000818:Animals; D001669:Biochemical Phenomena; D001692:Biological Transport; D006224:Cricetinae; D006207:Half-Life; D006801:Humans; D007421:Intestine, Small / Q000502:physiology*; D007422:Intestines; D008297:Male; D008715:Methionine / Q000378:metabolism*; D011868:Radioisotopes; D012643:Selenium / Q000378:metabolism*; D018036:Selenium Compounds; D012645:Selenomethionine
D000596:Amino Acids; D011868:Radioisotopes; D018036:Selenium Compounds; D012645:Selenomethionine; D008715:Methionine; D012643:Selenium
INTESTINE, SMALL/physiology; METHIONINE/metabolism; SELENIUM/metabolism