Metabolic deficiencies in protozoa induced by thalidomide.
Thalidomide inhibits growth of some protozoa. This inhibition was counteracted by nicotinic acid, nicotinamide, nicotinamide adenine dinucleotide, and vitamin K(1). The mechanism of toxicity may be an interference of cellular oxidation. A protozoan test system is useful for studying the potential "side actions" of drugs in higher animals and man.
D000818:Animals; D005055:Euglena; D056890:Eukaryota; D006801:Humans; D007448:Invertebrates; D008297:Male; D009536:Niacinamide; D013768:Tetrahymena; D013792:Thalidomide
D009536:Niacinamide; D013792:Thalidomide
EUGLENA; MASTIGOPHORA; TETRAHYMENA; THALIDOMIDE