17-ketosteroid and 17-hydroxycorticosteroid excretion in patients with duodenal ulceration.
The 24-hour excretion of 17-ketosteroids and 17-hydroxycorticosteroids has been estimated in a series of male duodenal ulcer subjects and compared with that of 56 normal male controls. It has been found that both 17-ketosteroid and 17-hydroxycorticosteroid excretion is less in ulcer subjects than in the control group; these differences are not large but in the case of 17-hydroxycorticosteroids they are statistically significant. For active ulcers (107 men) 17-hydroxycorticosteroid excretion is approximately 78% of normal and 17-ketosteroid excretion 93% of normal; in the quiescent phase (50 men) the differences are rather larger, being respectively 71% and 86% of normal. This reduced excretion persists after operation in both the short term, six months after operation (53 men), and the long term, 10 years and more after gastric resection (39 men).
D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D000305:Adrenal Cortex Hormones; D004381:Duodenal Ulcer; D006801:Humans; D008297:Male
D015065:17-Hydroxycorticosteroids; D015068:17-Ketosteroids; D000305:Adrenal Cortex Hormones
17-KETOSTEROIDS; ADRENAL CORTEX HORMONES; DUODENAL ULCER