Glycogen deposition in the liver induced by cortisone: dependence on enzyme synthesis.
The deposition of liver glycogen in starved rats given a single dose of cortisone is inhibited by puromycin and actinomycin. The former agent interferes with induced enzyme formation in general, and the latter with the cortisone-induced rise in liver enzyme levels. The results suggest that the regulatory eJffect of cortisone on carbohydrate metabolism may be brought about -by its action on the cellular concentration of certain enzyme proteins.
D000818:Animals; D050260:Carbohydrate Metabolism; D003348:Cortisone; D003609:Dactinomycin; D008099:Liver; D008112:Liver Glycogen; D011506:Proteins; D011691:Puromycin; D051381:Rats; D000637:Transaminases
D008112:Liver Glycogen; D011506:Proteins; D003609:Dactinomycin; D011691:Puromycin; D000637:Transaminases; D003348:Cortisone
AMINOTRANSFERASES; CORTISONE; LIVER GLYCOGEN