Effects of some guanidine derivatives on neuromuscular and ganglionic transmission.
The anticurare activity of some guanidine derivatives has been studied using the fowl sciatic nerve-gastrocnemius muscle preparation and the cat sciatic nerve-gastrocnemius and tibialis anterior muscle preparations. Among the compounds tested, and in decreasing order of potency, were NN-dimethylguanidine, N-methylguanidine, guanidine and N-aminoguanidine which antagonized or prevented tubocurarine or gallamine triethiodide-induced paralysis. None of the derivatives antagonized the effects of suxamethonium or decamethonium. NN-Dimethylguanidine, N-methylguanidine and guanidine antagonized or prevented the curare-like effects of magnesium without altering the activity of hemicholinium. At high doses NN-dimethylguanidine induced a decamethonium-like spastic paralysis in the fowl sciatic nerve-gastrocnemius muscle preparation. NN-Diethylguanidine, however, induced a tubocurarine-like flaccid paralysis. The derivatives possessing anticurare activity were also studied using the cat superior cervical ganglion-nictitating membrane preparation to check their possible effects against ganglionic blocking agents. Only guanidine antagonized or prevented the effects of hexamethonium, pentolinium and mecamylamine; it had no effect on the actions of pempidine and chlorisondamine. NN-Diethylguanidine was the only compound in the series to show a ganglionic blocking action.
D000818:Animals; D000959:Antihypertensive Agents; D002415:Cats; D002714:Chlorisondamine; D003650:Decamethonium Compounds; D005703:Gallamine Triethiodide; D005730:Ganglionic Blockers; D019791:Guanidine; D006146:Guanidines; D006584:Hexamethonium Compounds; D008464:Mecamylamine; D009469:Neuromuscular Junction; D009541:Nictitating Membrane; D010393:Pempidine; D010425:Pentolinium Tartrate; D013390:Succinylcholine; D014403:Tubocurarine
D000959:Antihypertensive Agents; D003650:Decamethonium Compounds; D005730:Ganglionic Blockers; D006146:Guanidines; D006584:Hexamethonium Compounds; D008464:Mecamylamine; D010425:Pentolinium Tartrate; C033019:decamethonium; D013390:Succinylcholine; D002714:Chlorisondamine; D019791:Guanidine; D010393:Pempidine; D005703:Gallamine Triethiodide; D014403:Tubocurarine
CHLORISONDAMINE; DECAMETHONIUM COMPOUNDS; GALLAMINE TRIETHIODIDE; GUANIDINES; HEXAMETHONIUM COMPOUNDS; MECAMYLAMINE; MYONEURAL JUNCTION; NICTITATING MEMBRANE; PEMPIDINE; PENTOLINIUM TARTRATE; SUCCINYLCHOLINE; TUBOCURARINE