Effect of chlorpromazine, reserpine, benactyzine and phenobarbitone on the release of corticotrophin in the rat.
A single injection into the rat of chlorpromazine, reserpine, benactyzine or phenobarbitone stimulates the release of corticotrophin. This effect is not seen after the drugs have been injected daily for 5 days, nor when the rats are hypophysectomized or pretreated with hydrocortisone. The stimulant effect of ether on corticotrophin release is not modified by pretreatment with a single injection, nor to any great extent after 5 daily injections of these drugs.
D000324:Adrenocorticotropic Hormone; D000818:Animals; D001205:Ascorbic Acid; D001535:Benactyzine; D000697:Central Nervous System Stimulants; D002746:Chlorpromazine; D006854:Hydrocortisone; D010634:Phenobarbital; D051381:Rats; D012110:Reserpine
D000697:Central Nervous System Stimulants; D001535:Benactyzine; D012110:Reserpine; D000324:Adrenocorticotropic Hormone; D001205:Ascorbic Acid; D002746:Chlorpromazine; D006854:Hydrocortisone; D010634:Phenobarbital
ASCORBIC ACID; BENACTYZINE; CHLORPROMAZINE; CORTICOTROPIN; PHENOBARBITAL; RESERPINE