Some neurochemical aspects of the depressant action of gamma-butyrolactone on the central nervous system.
gamma-Butyrolactone, a depressant drug of the central nervous system, has been investigated for its ability to alter brain levels of 5-hydroxytryptamine, gamma-aminobutyric acid and acetylcholine in mice and rats; of these three compounds, only acetylcholine was changed in amount. Levels of acetylcholine in the cerebral cortex were increased by gamma-butyrolactone with a time-course which closely followed the depressed state of the animal. Indirect evidence has been presented to show that in the mid-brain and brain stem the change in acetylcholine level induced by gamma-butyrolactone is sharply localized in an area of the mesencephalon that contains the corpora quadrigemina.
D015107:4-Butyrolactone; D000109:Acetylcholine; D000596:Amino Acids / Q000652:urine*; D000818:Animals; D001921:Brain; D002490:Central Nervous System; D006993:Hypnotics and Sedatives; D007783:Lactones; D051379:Mice; D051381:Rats; D012701:Serotonin; D005680:gamma-Aminobutyric Acid
D000596:Amino Acids; D006993:Hypnotics and Sedatives; D007783:Lactones; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine; D015107:4-Butyrolactone
ACETYLCHOLINE; AMINO ACIDURIA; BRAIN; HYPNOTICS AND SEDATIVES; LACTONES; SEROTONIN