A drug-specific leuco-agglutinin in a fatal case of agranulocytosis due to chlorpromazine.
A fatal case of agranulocytosis due to chlorpromazine is reported. Mechanisms other than immunological are generally believed to be responsible for chlorpromazine-induced agranulocytosis. However, the demonstration of a drug-specific leuco-agglutinin in the serum of this patient suggests that an immunological mechanism was responsible for the agranulocytosis.
D000373:Agglutinins; D000380:Agranulocytosis; D000906:Antibodies; D001249:Asthma; D002746:Chlorpromazine; D002747:Chlorpropamide; D004342:Drug Hypersensitivity; D006801:Humans
D000373:Agglutinins; D000906:Antibodies; D002746:Chlorpromazine; D002747:Chlorpropamide
AGRANULOCYTOSIS; ANTIBODIES; ASTHMA; CHLORPROPAMIDE; DRUG ALLERGY