Effects of bacterial endotoxin on rabbit platelets. II. Enhancement of platelet factor 3 activity in vitro and in vivo.
Incubation of rabbit platelet-rich plasma with bacterial endotoxin results in activation of platelet factor 3, a precursor of blood thromboplastin. This platelet-endotoxin interaction is dose- and temperature-dependent, and is similar to the effects of antigen-antibody union in the presence of platelets. Injection of endotoxin intravenously is associated with a transient increase in platelet factor 3. Since platelet factor 3 can be demonstrated in platelet-poor plasma as well as platelet-rich plasma after endotoxin injection, it seems likely that an actual transfer of factor 3 from platelets to plasma occurs and that this activity is then rapidly inactivated or cleared from the blood stream.
D000818:Animals; D001779:Blood Coagulation Factors; D001792:Blood Platelets; D004731:Endotoxins; D066298:In Vitro Techniques; D010977:Platelet Factor 3; D011817:Rabbits; D013925:Thromboplastin
D001779:Blood Coagulation Factors; D004731:Endotoxins; D010977:Platelet Factor 3; D013925:Thromboplastin
BLOOD COAGULATION FACTORS; BLOOD PLATELETS; ENDOTOXINS