Poisoning by organic phosphorus pesticides potentiated by phenothiazine derivatives.
Repeated administration of the phenothiazine derivatives chlorpromazine and promazine increased the toxicity of a single dose of parathion in male rats. In female rats, a single dose of 5 mg/kg of promazine increased the toxicity of a single dose of parathion, but had no apparent effect on the toxicity of a single dose of Phosdrin. Repeated dosage with chlorpromazine and atropine, or promazine and atropine, after administration of parathion at the same rate, resulted in a slightly higher mortality in female rats than did atropine or no treatment.
D000818:Animals; D014150:Antipsychotic Agents; D002746:Chlorpromazine; D005260:Female; D008297:Male; D010278:Parathion; D010575:Pesticides; D010640:Phenothiazines; D010758:Phosphorus; D011395:Promazine; D051381:Rats
D014150:Antipsychotic Agents; D010575:Pesticides; D010640:Phenothiazines; D010758:Phosphorus; D010278:Parathion; D011395:Promazine; D002746:Chlorpromazine
CHLORPROMAZINE; PARATHION; PESTICIDES; PROMAZINE