A plaque method for rubella virus assay.
A method has been described in which suitable dilutions of rubella virus will induce the formation, in a monolayer of green monkey kidney cells, of islets of infected cells which were protected from the effects of Echo 11 challenge virus. The number of islets or "negative" plaques was proportional to the dilution of rubella virus inoculated on to the monolayer. Using this method, it was observed that bentonite adsorption increased the plaque assay values of rubella virus pools. This suggested that rubella virus interference may be mediated by an interferon-like principle.
D000818:Animals; D001681:Biological Assay; D002522:Chlorocebus aethiops; D029822:Enterovirus B, Human; D007372:Interferons; D012409:Rubella; D012412:Rubella virus; D014780:Viruses
D007372:Interferons
ANIMAL VIRUSES; RUBELLA