Nitrogen mustard: diminution of toxicity in axenic mice.
Axenic, or germ-free, mice are more resistant to the delayed lethal effect of nitrogen mustard than normal mice. The resistance is most striking when mustard is administered at pH 2.0. The finding supports the hypothesis that intestinal bacteria play an important role in the systemic toxicity of nitrogen mustard.
D000818:Animals; D005856:Germ-Free Life; D007422:Intestines / Q000382:microbiology*; D008466:Mechlorethamine; D051379:Mice; D009355:Neomycin; D010118:Oxytetracycline; D011113:Polymyxins
D011113:Polymyxins; D008466:Mechlorethamine; D009355:Neomycin; D010118:Oxytetracycline
GERM-FREE LIFE; INTESTINAL MICROORGANISMS; MECHLORETHAMINE; NEOMYCIN; OXYTETRACYCLINE; POLYMYXIN