Specific immunologic unresponsiveness to synthetic polypeptide antigens.
The injection of two synthetic polypeptide antigens into adult rabbits treated with 6-mercaptopurine, or into newborn rabbits, resulted in immunological "unresponsiveness" to subsequent immunizations with these antigens. The "tolerant" animals were shown to be reactive toward the non-related antigen ovalbumin.
D000818:Animals; D000941:Antigens; D007108:Immune Tolerance; D007114:Immunization; D010047:Ovalbumin; D010455:Peptides; D011817:Rabbits; D014614:Vaccines, Synthetic
D000941:Antigens; D010455:Peptides; D014614:Vaccines, Synthetic; D010047:Ovalbumin
ANTIGENS; PEPTIDES