Effects of folic acid on the phenylalanine tolerance test in phenylketonuria.
Phenylalanine tolerance tests were performed on four untreated children with phenylketonuria, aged 8 to 12 years, before and after 14 days of folic acid administration (70 mg./day). No significant changes were noted in the phenylalanine tolerance tests or in the general condition of the patients. This study was carried out because of recent findings that a folic acid derivative is a co-factor in the conversion of phenylalanine to tyrosine.
D000963:Antimetabolites; D002648:Child; D004361:Drug Tolerance; D005492:Folic Acid; D006801:Humans; D007108:Immune Tolerance; D010649:Phenylalanine; D010661:Phenylketonurias; D014443:Tyrosine
D000963:Antimetabolites; D014443:Tyrosine; D010649:Phenylalanine; D005492:Folic Acid
FOLIC ACID; PHENYLKETONURIA