Actions of bretylium and guanethidine on the uptake and release of [3H]-noradrenaline.
The effect of bretylium and guanethidine has been studied on the uptake and the spontaneous and reserpine-induced release of [(3)H]-noradrenaline in the rat heart and in the splenic nerve endings of the cat. Bretylium and guanethidine inhibited the uptake by the heart of circulating [(3)H]-noradrenaline. Bretylium blocked spontaneous and reserpine-induced release of [(3)H]-noradrenaline, while guanethidine caused release and partially antagonized the reserpine-induced release. Both compounds produced a transient liberation of [(3)H]-noradrenaline from splenic nerves, but blocked the release of the [(3)H]-catechol amine following stimulation of the splenic nerve.
D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001949:Bretylium Compounds; D002395:Catecholamines; D002415:Cats; D006145:Guanethidine; D006321:Heart / Q000494:pharmacology*; D009638:Norepinephrine; D051381:Rats; D012110:Reserpine; D013154:Spleen / Q000494:pharmacology*
D000578:Amidines; D000959:Antihypertensive Agents; D001949:Bretylium Compounds; D002395:Catecholamines; D012110:Reserpine; C045166:bretylium; D009638:Norepinephrine; D006145:Guanethidine
AMIDINES/pharmacology; ANTIHYPERTENSIVE AGENTS/pharmacology; HEART/pharmacology; SPLEEN/pharmacology