Nonbiological conversion of cephalosporin C to a new antibiotic by sodium thiosulfate.
The apparent stimulation of cephalosporin C biosynthesis by sodium thiosulfate is due to a nonbiological conversion of cephalosporin C to a new derivative, cephalosporin C(x). The new compound is more active than cephalosporin C against the assay organism, Escherichia coli W-208. Cephalosporin C(x) retains the properties of ultraviolet absorption and resistance to penicillinase, but migrates more slowly than cephalosporin C in the paper-chromatographic system used.
D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D002511:Cephalosporins; D004926:Escherichia coli; D008715:Methionine; D010405:Penicillinase; D012964:Sodium; D013885:Thiosulfates
D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D002511:Cephalosporins; D013885:Thiosulfates; C025163:cephalosporin C; D012964:Sodium; D008715:Methionine; D010405:Penicillinase; C017717:sodium thiosulfate
ANTIBIOTICS; ESCHERICHIA COLI; METHIONINE; SODIUM; THIOSULFATES