Site of action of chlorpromazine and mephenesin in experimental tetanus.
The anti-tetanus activities of chlorpromazine and mephenesin have been determined quantitatively in intact, spinal and decerebrate rabbits with local tetanus. The activity of chlorpromazine in the spinal animal differed from that in the intact and decerebrate animal and depended on the level of brain-stem section. Mephenesin was equally effective in all preparations and probably suppressed tetanus by blocking transmission in motor pathways in the spinal cord.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D008615:Mephenesin / Q000494:pharmacology*; D011817:Rabbits; D013116:Spinal Cord; D013742:Tetanus; D013745:Tetanus Toxoid
D013745:Tetanus Toxoid; D008615:Mephenesin; D002746:Chlorpromazine
CHLORPROMAZINE/pharmacology; MEPHENESIN/pharmacology; TETANUS/experimental