Effect of methionine, norleucine, and lysine derivatives on cephalosporin C formation in chemically defined media.
Demain, A. L. (Merck Sharp & Dohme Research Laboratories, Rahway, N.J.), Joanne F. Newkirk, and D. Hendlin. Effect of methionine, norleucine, and lysine derivatives on cephalosporin C formation in chemically defined media. J. Bacteriol. 85: 339-344. 1963.-Chemically defined media were developed for production of cephalosporin C by Cephalosporium sp. In such media, the requirement for methionine can be satisfied by norleucine. Further stimulation of antibiotic production was obtained with the lysine derivatives epsilon-N-acetyl-l-lysine and epsilon-aminocaproic acid but not with lysine itself. Also inactive were alpha-aminoadipic and ketoadipic acids. Other lysine derivatives were found to inhibit cephalosporin C production at 0.01 m. The final medium supported the production of approximately 0.5 g of cephalosporin C per liter of medium.
D000164:Acremonium; D002511:Cephalosporins; D003470:Culture Media; D007930:Leucine; D008239:Lysine / Q000031:analogs & derivatives; D008715:Methionine; D009646:Norleucine
D002511:Cephalosporins; D003470:Culture Media; C025163:cephalosporin C; C016949:N-epsilon-acetyllysine; D009646:Norleucine; D008715:Methionine; D007930:Leucine; D008239:Lysine
CEPHALOSPORIUM; CULTURE MEDIA; LEUCINE; LYSINE; METHIONINE