Protection of rats against adjuvant arthritis by bacterial lipoplysaccharides.
Lipopolysaccharides from both gram-negative and gram-positive bacteria in incomplete adjuvant caused rats to become resistant to mycobacterial (complete) adjuvant arthritis. Lipopolysaccharides h protected rats when they were administered in adjuvant did not protect when administered in saline. Mycobacterial wax D in saline was protective, while in adjuvant it produced arthritis. The degree of stimulation of a common tissue reaction may determine whether the result is protection or disease.
D000818:Animals; D001168:Arthritis; D001169:Arthritis, Experimental; D001419:Bacteria / Q000737:chemistry*; D006094:Gram-Positive Bacteria; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051381:Rats
D008070:Lipopolysaccharides
ARTHRITIS/experimental; BACTERIA/chemistry; LIPOPOLYSACCHARIDES/pharmacology