Similarly between receptors responsible for the production of analgesia and lenticular opacity.
Evidence is presented that the receptors responsible for the mediation of analgesia by morphine-like drugs are similar to those which are involved in the production of a reversible lenticular opacity. The activity of a number of compounds in mice on the lens was closely correlated with analgesic potency in this species. Stereospecificity for isomers with D configuration was demonstrated for both effects. Nalorphine only antagonized the lenticular opacity activity of those drugs the analgesic action of which it abolished.
D000698:Analgesia; D000700:Analgesics; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D058633:Antipyretics; D007908:Lens, Crystalline / Q000494:pharmacology*; D007909:Lenses; D051379:Mice; D009020:Morphine; D009269:Nalorphine; D059408:Pain Management
D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D058633:Antipyretics; D009020:Morphine; D009269:Nalorphine
ANALGESICS AND ANTIPYRETICS/pharmacology; LENS, CRYSTALLINE/pharmacology