Actions of certain amines on cerebral cortical neurones.
A number of derivatives of tryptamine and phenethylamine, and certain other compounds, were tested on neurones in the cerebral cortex of cats by iontophoretic release from micro-pipettes. The characteristic action of many of these compounds was a depression of the neuronal discharge initiated by synaptic activity or by the application of L-glutamate; imidazolylacetic acid, dopamine, ephedrine and ergometrine were particularly effective. Catechol amines, hydroxytryptamines and imidazolylacetic acid had a relatively quick and rapidly reversible action, not unlike that of gamma-aminobutyric acid, whereas ephedrine and derivatives of lysergic acid diethylamide caused a slower and more prolonged depression of the amplitude of spikes, rather like atropine. Several compounds, including 5-hydroxytryptamine, adrenaline and ergometrine, could also excite the same neurone when larger amounts were applied. A few substances, such as dopa and methylergometrine, had a predominantly excitant action.
D000588:Amines; D000818:Animals; D002415:Cats; D002540:Cerebral Cortex; D004298:Dopamine; D004837:Epinephrine; D018698:Glutamic Acid; D008238:Lysergic Acid Diethylamide; D009474:Neurons; D012701:Serotonin; D012704:Serous Membrane; D014363:Tryptamines; D005680:gamma-Aminobutyric Acid
D000588:Amines; D014363:Tryptamines; D012701:Serotonin; D018698:Glutamic Acid; C030820:tryptamine; D005680:gamma-Aminobutyric Acid; D008238:Lysergic Acid Diethylamide; D004298:Dopamine; D004837:Epinephrine
CEREBRAL CORTEX; DOPAMINE; EPINEPHRINE; LYSERGIC ACID DIETHYLAMIDE; NEURONS; SEROUS MEMBRANE