Sarcoma 180 inhibition by combinations of 6-thioguanine and uracil mustard.
Combinations of 6-thioguanine and uracil mustard produced greater inhibition of the growth of sarcoma 180 than that equivalent to the sum of the inhibitory effects caused by the optimum levels of the individual drugs. This potentiation was accomplished without marked weight loss by the host. Some possible biochemical mechanisms responsible for the drug synergy are discussed.
D000818:Animals; D000970:Antineoplastic Agents; D015122:Mercaptopurine; D012510:Sarcoma 180; D013866:Thioguanine; D014498:Uracil; D014499:Uracil Mustard
D000970:Antineoplastic Agents; D014498:Uracil; D015122:Mercaptopurine; D013866:Thioguanine; D014499:Uracil Mustard
ANTINEOPLASTIC AGENTS; MERCAPTOPURINE; SARCOMA 180, CROCKER; URACIL