BRADYKININ: VASCULAR RELAXANT, CARDIAC STIMULANT.
Bradykinin infusion causes an increase in cardiac output in rats whether the autonomic nervous system is blocked or not. After autonomic blockade, bradykinin causes a lesser decrease in the total peripheral resistance but a greater increase in cardiac output, resulting in an elevation of arterial pressure. The increase in cardiac output is caused by a small increase in heart rate and a substantial increase in stroke volume. The fact that these increases are observed after autonomic blockade suggests that bradykinin increases cardiac output by direct stimulation of the heart.
D001340:Autonomic Nerve Block; D001794:Blood Pressure; D001920:Bradykinin; D002302:Cardiac Output; D002316:Cardiotonic Agents; D006321:Heart; D006339:Heart Rate; D006439:Hemodynamics; D007263:Infusions, Parenteral; D010425:Pentolinium Tartrate; D051381:Rats; D012106:Research; D013318:Stroke Volume; D014655:Vascular Resistance
D002316:Cardiotonic Agents; D010425:Pentolinium Tartrate; D001920:Bradykinin
AUTONOMIC NERVE BLOCK; BRADYKININ; EXPERIMENTAL LAB STUDY; HEART; INFUSIONS, PARENTERAL; PENTOLINIUM TARTRATE; RATS