INHIBITION OF THE GROWTH OF AGENTS OF THE PSITTACOSIS GROUP BY D-CYCLOSERINE AND ITS SPECIFIC REVERSAL BY D-ALANINE.
Moulder, James W. (University of Chicago, Chicago, Ill.), Dorothy L. Novosel, and Julius E. Officer. Inhibition of the growth of agents of the psittacosis group by d-cycloserine and its specific reversal by d-alanine. J. Bacteriol. 85:707-711. 1963.-d-Cycloserine inhibited multiplication of four members of the psittacosis group in chick embryo yolk sac. d-Alanine reversed each inhibition. In infections with the agent of mouse pneumonitis, the most sensitive member of the psittacosis group tested, d-alanine competitively antagonized the growth inhibition produced by d-cycloserine. Of a number of other potential reversing agents, only dl-alanyl-dl-alanine reversed the effect of d-cycloserine on mouse pneumonitis agent. The significance of the susceptibility of the psittacosis group to d-cycloserine is discussed in light of the known mode of action of this antibiotic on bacteria.
D000409:Alanine; D000818:Animals; D002642:Chick Embryo; D002689:Chlamydia; D002691:Chlamydophila psittaci; D003523:Cycloserine; D051379:Mice; D009956:Psittacosis; D046509:Tissue Culture Techniques; D014776:Virus Cultivation
D003523:Cycloserine; D000409:Alanine
ALANINE; CYCLOSERINE; MIYAGAWANELLA; TISSUE CULTURE; VIRUS CULTIVATION