DISSOCIATION OF HOMOGRAFT RESPONSE TO ALLOGENEIC VERSUS XENOGENEIC SKIN GRAFTS IN IRRADIATED MICE.
Lethally x-irradiated (C3H x DBA/2)F(1) mice were protected with syngeneic (isogenic) bone marrow and/ or prior treatment with urethan and skin grafted at various times after irradiation. The ability to reject a first-set xenogeneic (heterologous) skin graft with normal vigor returned within 92 days; the first-set response to allogeneic (homologous) grafts was still impaired 350 days after irradiation.
D064591:Allografts; D000818:Animals; D001853:Bone Marrow; D016026:Bone Marrow Transplantation; D051379:Mice; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D011832:Radiation Injuries; D011833:Radiation Injuries, Experimental; D012106:Research; D016038:Skin Transplantation; D014184:Transplantation, Homologous; D014520:Urethane
D014520:Urethane
BONE MARROW TRANSPLANTATION; EXPERIMENTAL LAB STUDY; MICE; RADIATION INJURY, EXPERIMENTAL; SKIN TRANSPLANTATION; URETHANE