CLINICAL STUDIES OF NEUROPATHY DUE TO MACROGLOBULINEMIA (WALDENSTROEM'S SYNDROME).
A case of severe neuropathy due to macro-globulinemia is reported with clinical, biochemical and electrophysiological studies. The clinical picture was that of a severe, symmetrical polyneuropathy of a sensory-motor type with increased protein in the CSF. Sedimentation rate was increased and a sharp rise was found in the globulin fractions on plasma electrophoresis. Immuno-assays of CSF showed increases of albumin, transferrin and gamma globulin. Blood chromosome studies were normal. EMG showed neuromuscular atrophy. Nerve conduction times were prolonged. These studies are compatible with a neuropathy of an allergic or metabolic nature. Macro-globulinemia of Waldenström should be considered in the differential diagnosis of obscure neuropathies.
D001774:Blood Chemical Analysis; D002556:Cerebrospinal Fluid Proteins; D004032:Diet; D004586:Electrophoresis; D005492:Folic Acid; D006801:Humans; D009069:Movement Disorders; D009133:Muscular Atrophy; D009431:Neural Conduction; D009461:Neurologic Manifestations; D010523:Peripheral Nervous System Diseases; D013577:Syndrome; D014665:Vasodilator Agents; D014803:Vitamin B Complex; D008258:Waldenstrom Macroglobulinemia; D005719:gamma-Globulins
D002556:Cerebrospinal Fluid Proteins; D014665:Vasodilator Agents; D005719:gamma-Globulins; D014803:Vitamin B Complex; D005492:Folic Acid
BLOOD CHEMICAL ANALYSIS; CEREBROSPINAL FLUID PROTEINS; DIET; MACROGLOBULINEMIA; MOVEMENT DISORDERS; MUSCULAR ATROPHY; NEUROLOGIC MANIFESTATIONS; VASODILATOR AGENTS; VITAMIN B COMPLEX