SPORICIDAL ACTIVITY OF ALKALINE ALCOHOLIC SATURATED DIALDEHYDE SOLUTIONS.
During a search for a sporicidal agent to equal or surpass formaldehyde in activity, a group of saturated dialdehydes ranging from two to six carbons was discovered. These dialdehydes exerted a surprisingly high degree of activity in isopropanol buffered with a carbonate or bicarbonate. Without the proper buffer, practically no activity was observed. A solution of 1% glutaraldehyde, 0.3% NaHCO(3), and 70% isopropanol sterilized stainless-steel penicylinders contaminated with standardized numbers of four spore types in a shorter time than did commercially available 8% formaldehyde solution. Both glyoxal and glutaraldehyde in isopropanol destroyed spores in a relatively short time. Care was taken to eliminate bacteriostasis. Various tests were performed to evaluate accurately experimental and formaldehyde solutions.
D000438:Alcohols; D000447:Aldehydes; D005557:Formaldehyde; D005976:Glutaral; D006037:Glyoxal; D008829:Microbiology; D012106:Research; D012996:Solutions; D013171:Spores, Bacterial; D013193:Stainless Steel; D013242:Sterilization
D000438:Alcohols; D000447:Aldehydes; D012996:Solutions; D013193:Stainless Steel; D005557:Formaldehyde; D006037:Glyoxal; D005976:Glutaral
ALCOHOLS; ALDEHYDES; EXPERIMENTAL LAB STUDY; MICROBIOLOGY