ANTAGONISM OF D-CYCLOSERINE INHIBITION OF MYCOBACTERIAL GROWTH BY D-ALANINE.
Zygmunt, Walter A. (Mead Johnson & Co., Evansville, Ind.). Antagonism of d-cycloserine inhibition of mycobacterial growth by d-alanine. J. Bacteriol. 85:1217-1220. 1963.-Reversal of the antimycobacterial activity of d-4-amino-3-isoxazolidinone (d-cycloserine) by alanine in two species of mycobacteria actively growing on chemically defined media was compared. In both instances, d-alanine was the most effective reversal agent. The specificity with which the d isomer reversed the antimycobacterial activity of d-cycloserine was more pronounced than that observed with other species of bacteria. Mycobactin, a growth factor for certain mycobacteria, showed no reversal activity.
D000409:Alanine; D003523:Cycloserine; D009161:Mycobacterium; D012106:Research
D003523:Cycloserine; D000409:Alanine
ALANINE; CYCLOSERINE; EXPERIMENTAL LAB STUDY; MYCOBACTERIUM