ACETYLCHOLINE-LIKE ACTIVITY IN SCIATIC NERVE.
Extracts of sciatic nerve exhibit acetylcholine-like activity that is only partly attributable to acetylcholine. The extracts show relatively greater activity on the rectus abdominis muscle of the frog than on the ileum of the guinea pig. To prevent the action of the extract on the frog rectus abdominis muscle, a greater concentration of d-tubocurarine is required than is necessary to prevent the action of known acetylcholine.
D034861:Abdominal Wall; D000109:Acetylcholine; D000818:Animals; D001001:Anura; D001285:Atropine; D002498:Centrifugation; D002845:Chromatography; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists; D007082:Ileum; D008238:Lysergic Acid Diethylamide; D009132:Muscles; D011817:Rabbits; D012106:Research; D012584:Sciatic Nerve; D012701:Serotonin; D014403:Tubocurarine
D006634:Histamine H1 Antagonists; D012701:Serotonin; D001285:Atropine; D008238:Lysergic Acid Diethylamide; D000109:Acetylcholine; D014403:Tubocurarine
ABDOMINAL WALL; ACETYLCHOLINE; ANTIHISTAMINICS; ATROPINE; CENTRIFUGATION; CHROMATOGRAPHY; EXPERIMENTAL LAB STUDY; FROGS; GUINEA PIGS; ILEUM; LYSERGIC ACID DIETHYLAMIDE; MUSCLES; RABBITS; SCIATIC NERVE; SEROTONIN; TUBOCURARINE