A COMPARISON OF THE BIOLOGICAL ACTIVITIES OF FOUR PROSTAGLANDINS.
The biological activities of prostaglandins E(1), E(2), E(3) and F(1alpha) have been compared. Prostaglandins E(1), E(2), E(3) were qualitatively similar; E(1) and E(2) were about equiactive, but E(3) was less active on all preparations. Prostaglandin F(1alpha) was a less potent vasodilator than E(1) on the cat gastrocnemius muscle blood flow and skin blood flow and a less potent depressor drug on rabbit blood pressure. On the rabbit isolated jejunum F(1alpha) was twice as active as E(1) but on the guinea-pig isolated ileum E(1) was about forty times more active than F(1alpha). One qualitative difference between these prostaglandins was observed; on the rabbit fallopian tube in vivo prostaglandins of the E series decreased both the tone and the peristalsis of the tube whereas prostaglandin F(1alpha) increased tubal tone.
D000818:Animals; D001688:Biological Products; D001794:Blood Pressure; D002415:Cats; D006224:Cricetinae; D005187:Fallopian Tubes; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007082:Ileum; D007583:Jejunum; D007793:Lagomorpha; D009130:Muscle, Smooth; D010600:Pharmacology; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D011817:Rabbits; D051381:Rats; D012106:Research
D001688:Biological Products; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F
BIOLOGICAL PRODUCTS; CATS; EXPERIMENTAL LAB STUDY; GUINEA PIGS; HAMSTERS; PHARMACOLOGY; PROSTAGLANDINS; RABBITS; RATS