ACTINOMYCIN D EFFECTS IN FROG EMBRYOS: EVIDENCE FOR SEQUENTIAL SYNTHESIS  OF DNA-DEPENDENT RNA.
Early gastrulae of Rana pipiens exposed to actinomycin D for 2 days were then cultured in saline. The resulting larvae were immotile; histological examination revealed impaired development of axial nerve and muscle tissues, but normal differentiation of sensory, pronephric, heart, and digestive tissues; this suggests sequential synthesis of the different tissue-specific molecules of DNA-dependent RNA.
D000818:Animals; D001001:Anura; D002454:Cell Differentiation; D003470:Culture Media; D004247:DNA; D003609:Dactinomycin; D004622:Embryo, Mammalian; D004625:Embryo, Nonmammalian; D008660:Metabolism; D012313:RNA; D011898:Ranidae; D012106:Research; D012965:Sodium Chloride; D046509:Tissue Culture Techniques
D003470:Culture Media; D003609:Dactinomycin; D012965:Sodium Chloride; D012313:RNA; D004247:DNA
ACTINOMYCIN; CULTURE MEDIA; DNA; EMBRYO; EXPERIMENTAL LAB STUDY; FROGS; METABOLISM; RNA; SODIUM CHLORIDE; TISSUE CULTURE