NOREPINEPHRINE AND 3,4DIHYDROXYPHENETHYLAMINE TURNOVER IN GUINEA PIG BRAIN IN VIVO.
By administering C(14)-la-beled tyrosine or H(3)-labeled 3,4-dihy-droxyphenylalanine to guinea pigs it has been possible to achieve sufficient labeling of the norepinephrine and dopamine in the brain to permit measurement of their turnover rates. The half-life of brain dopamine was about 2.5 hours. The half-life of norepinephrine was about 4 hours, suggesting a rate of synthesis of at least 0.03 to 0.04, microg/g per hr or 2.4 microg/day for the whole guinea pig brain.
D000818:Animals; D001921:Brain; D002247:Carbon Isotopes; D004298:Dopamine; D006168:Guinea Pigs; D008660:Metabolism; D009638:Norepinephrine; D012106:Research; D014316:Tritium; D014443:Tyrosine
D002247:Carbon Isotopes; D014316:Tritium; D014443:Tyrosine; D004298:Dopamine; D009638:Norepinephrine
BRAIN; CARBON ISOTOPES; DOPAMINE; EXPERIMENTAL LAB STUDY; GUINEA PIGS; METABOLISM; NOREPINEPHRINE; TRITIUM; TYROSINE