TREMORINE: ITS EFFECT ON AMINES OF THE CENTRAL  NERVOUS SYSTEM.
The administration of tremogenidine doses of Tremorine, 1,4-dipyrrolidino-2 butyne, is followed by a significant decrease in the concentration of norepinephrine in the brain stem of three common laboratory species. The change in the concentration proceeds at a rate which coincides with the occurrence of the tremor in each of these species. In the rat, the change in norepinephrine is followed by a progressive increase in the concentration of 5-hydroxytryptamine in the brain stem. Bilateral adrenalectomy in the rat enhances the Tremorine-induced changes in the concentration of norepinephrine and antagonizes the increase in the concentration of S-hydroxytryptamine.
D000588:Amines; D000818:Animals; D001933:Brain Stem; D006571:Heterocyclic Compounds; D009638:Norepinephrine; D010600:Pharmacology; D051381:Rats; D012106:Research; D012701:Serotonin; D014202:Tremor; D014203:Tremorine
D000588:Amines; D006571:Heterocyclic Compounds; D012701:Serotonin; D014203:Tremorine; D009638:Norepinephrine
BRAIN STEM; EXPERIMENTAL LAB STUDY; HETEROCYCLIC COMPOUNDS; NOREPINEPHRINE; PHARMACOLOGY; SEROTONIN; TREMOR