PERIPHERAL NEUROPATHY FOLLOWING CHLOROQUINE THERAPY.
Four patients were observed who developed similar episodes of peripheral neuropathy following prolonged treatment with chloroquine phosphate. This previously unreported toxic reaction consisted of bilateral loss of knee and ankle reflexes and weakness of the quadriceps muscles. Gradual return to normal followed withdrawal of the chloroquine. Other toxic reactions to the drug are reviewed.
D001168:Arthritis; D001172:Arthritis, Rheumatoid; D002738:Chloroquine / Q000031:analogs & derivatives; D005853:Geriatrics; D010523:Peripheral Nervous System Diseases; D014116:Toxicology
C023676:chloroquine diphosphate; D002738:Chloroquine
ARTHRITIS, RHEUMATOID; CHLOROQUINE; GERIATRICS; PERIPHERAL NERVE DISEASES; TOXICOLOGIC REPORT