SYNERGISM BETWEEN SULPHONAMIDE DRUGS AND ANTIBIOTICS OF THE POLYMYXIN GROUP AGAINST PROTEUS SP. IN VITRO.
Interesting synergism in vitro between a recently introduced antibiotic, colistin methane sulphonate, and sulphonamide drugs is described. The observations were extended to polymyxin B sulphate and sulphonamides with essentially similar results. The combinations are bactericidal at therapeutic levels, the ratio of drugs to one another is not critical, and the effect is present over a fairly wide pH range.
D000900:Anti-Bacterial Agents; D003091:Colistin; D066298:In Vitro Techniques; D011113:Polymyxins; D011511:Proteus; D012106:Research; D000077145:Sulfanilamide; D013424:Sulfanilamides; D013449:Sulfonamides
D000900:Anti-Bacterial Agents; D011113:Polymyxins; D013424:Sulfanilamides; D013449:Sulfonamides; D000077145:Sulfanilamide; D003091:Colistin
COLISTIN; EXPERIMENTAL LAB STUDY; POLYMYXIN; PROTEUS; SULFONAMIDES