TREATMENT OF HYPERTENSION. AN EVALUATION OF  ALPHA-METHYLDOPA.
In a study utilizing an alternating double blind technique 15 patients were given alphamethyldopa in divided doses of 1 gram daily alone and in combination with a benzothiadiazine diuretic. The average blood pressure of patients receiving the drug alone was 157/90 mm of mercury, against the placebo control of 195/109 mm. The average blood pressure of patients receiving the drug in combination with a benzothiadiazine diuretic was 164/98 mm; in the control with placebo plus benzothiadiazine diuretic, it was 169/104 mm. Alpha-methyldopa appeared to be effective in reducing blood pressure in patients with benign essential hypertension.
D000959:Antihypertensive Agents; D001581:Benzothiadiazines; D001794:Blood Pressure; D004311:Double-Blind Method; D000075222:Essential Hypertension; D006801:Humans; D006973:Hypertension; D007022:Hypotension; D008750:Methyldopa; D010919:Placebos; D049993:Sodium Chloride Symporter Inhibitors
D000959:Antihypertensive Agents; D001581:Benzothiadiazines; D010919:Placebos; D049993:Sodium Chloride Symporter Inhibitors; D008750:Methyldopa
ANTIHYPERTENSIVE AGENTS; BENZOTHIADIAZINES; HYPERTENSION; METHYLDOPA; PLACEBOS