OBSERVATIONS ON THE ANTIHYPERTENSIVE AND SEDATIVE EFFECTS OF MEBUTAMATE, MEPROBAMATE AND RESERPINE.
Mebutamate, a propanediol derivative, has recently been introduced as an antihypertensive agent. In a double-blind, controlled study of 33 patients, the antihypertensive effect of mebutamate was not found to differ significantly from that of a placebo.The psychosedative properties of mebutamate did not differ from those of meprobamate. Reserpine, when given orally, lowered blood pressure and its antihypertensive activity was independent of its sedative properties.
D014151:Anti-Anxiety Agents; D000959:Antihypertensive Agents; D014150:Antipsychotic Agents; D001795:Blood Pressure Determination; D002219:Carbamates; D004311:Double-Blind Method; D006801:Humans; D006852:Hydrochlorothiazide; D006993:Hypnotics and Sedatives; D008620:Meprobamate; D010919:Placebos; D012110:Reserpine; D014116:Toxicology
D014151:Anti-Anxiety Agents; D000959:Antihypertensive Agents; D014150:Antipsychotic Agents; D002219:Carbamates; D006993:Hypnotics and Sedatives; D010919:Placebos; D006852:Hydrochlorothiazide; D012110:Reserpine; D008620:Meprobamate
ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE DETERMINATION; HYDROCHLOROTHIAZIDE; HYPNOTICS AND SEDATIVES; MEBUTAMATE; MEPROBAMATE; PLACEBOS; RESERPINE; TOXICOLOGIC REPORT