INHIBITION OF SYNTHESIS OF THE CELL WALL OF STAPHYLOCOCCUS AUREUS BY CEPHALOTHIN.
Cephalothin, 7-(thiophene-2-acetamido)-cephalosporanic acid, suppresses synthesis of the cell of Staphylococcus aureus. Exposure to this agent led to a reduction in the degree of incorporation of carbon-14-lysine into the mucopeptide of the cell wall material and to an accumulation of N-acetyl glucosamine in the cell. The intensity of the lesions was comparable to that produced by penicillin.
D000900:Anti-Bacterial Agents; D002250:Carbon Radioisotopes; D003585:Cell Biology; D002473:Cell Wall; D002512:Cephalothin; D008660:Metabolism; D010406:Penicillins; D012106:Research; D013210:Staphylococcus; D013211:Staphylococcus aureus
D000900:Anti-Bacterial Agents; D002250:Carbon Radioisotopes; D010406:Penicillins; D002512:Cephalothin
ANTIBIOTICS; CEPHALOTHIN; CYTOLOGY; EXPERIMENTAL LAB STUDY; METABOLISM; STAPHYLOCOCCUS