VITAMIN D3: DIRECT ACTION ON THE SMALL INTESTINE OF THE RAT.
Vitamin D(3) placed directly into loops of rat duodenum in vitamin D deficient animals increases markedly the subsequent transport of calcium by slices of the duodenal loop in vitro. Under similar conditions the same dose of vitamin given intravenously or placed in a jejunal loop has little or no effect on the duodenal tissue. Thus the vitamin acts directly on the small intestine without prior activation in another organ.
D000818:Animals; D001692:Biological Transport; D002118:Calcium; D002762:Cholecalciferol; D004386:Duodenum; D007421:Intestine, Small; D008660:Metabolism; D010600:Pharmacology; D051381:Rats; D012106:Research; D014808:Vitamin D Deficiency
D002762:Cholecalciferol; D002118:Calcium
CALCIUM; CHOLECALCIFEROL; EXPERIMENTAL LAB STUDY; INTESTINE, SMALL; METABOLISM; PHARMACOLOGY; RATS