HYDROXYUREA: MECHANISM OF ACTION.
Acetohydroxamic acid has been identified, by paper chromatography, in the blood of three patients with chronic myelogenous leukemia on hydroxyurea therapy. This suggests that the drug is hydrolyzed yielding hyroxylamine, which then cleaves thioesters, in particular acetyl-coenzyme A.
D001774:Blood Chemical Analysis; D002845:Chromatography; D006801:Humans; D006877:Hydroxamic Acids; D006918:Hydroxyurea; D007938:Leukemia; D007951:Leukemia, Myeloid; D014508:Urea; D014556:Urine
D006877:Hydroxamic Acids; C006358:acetohydroxamic acid; D014508:Urea; D006918:Hydroxyurea
BLOOD CHEMICAL ANALYSIS; CHROMATOGRAPHY; HYDROXAMIC ACID; LEUKEMIA, MYELOCYTIC; UREA; URINE