CONVULSANT DRUG ACTION ON NEURONALLY ISOLATED CEREBRAL CORTEX.
After topical application of thiosemicarbazide, semicarbazide, or isoniazid to the surface of an isolated region of cortex, convulsive responses to electrical stimulation appeared only after a finite number of normal responses had been elicited, and disappeared again if stimulation was interrupted for about 10 minutes. With any of the other convulsant drugs tested, development of the convulsive pattern was independent of whether or not the cortex was stimulated. The two groups of drugs evidently have dijferent modes of action.
D002415:Cats; D000697:Central Nervous System Stimulants; D002540:Cerebral Cortex; D003292:Convulsants; D007538:Isoniazid; D010600:Pharmacology; D012106:Research; D013331:Strychnine; D013882:Thiosemicarbazones
D000697:Central Nervous System Stimulants; D003292:Convulsants; D013882:Thiosemicarbazones; D013331:Strychnine; D007538:Isoniazid
ANALEPTICS; CATS; CEREBRAL CORTEX; EXPERIMENTAL LAB STUDY; ISONIAZID; PHARMACOLOGY; STRYCHNINE; THIOSEMICARBAZONES