PLASMA VOLUME EXPANSION BY RAPID INFUSION OF A LOW MOLECULAR WEIGHT DEXTRAN.
Large infusions of a 10% solution of dextran of molecular weight 40,000 were given to dogs during 3 min using a specially designed apparatus. The initial expansion of plasma volume was about twice the volume of solution injected. Plasma volume then fell rapidly (with a half life of about 2 hr), more rapidly than the fall in dextran concentration (half-life of about 4.5 hr). Fluctuations in plasma volume and protein concentration were repeatedly observed during the return towards normal values. At 5 to 6 hr renal excretion accounted for 40% of the infused dextran, about 20% was intravascular and the remaining 40% was presumably extravascular. No dextran was found in the cerebrospinal fluid.
D000818:Animals; D001798:Blood Proteins; D001810:Blood Volume; D003911:Dextrans; D004285:Dogs; D006207:Half-Life; D006400:Hematocrit; D007263:Infusions, Parenteral; D008970:Molecular Weight; D010600:Pharmacology; D010952:Plasma Substitutes; D010953:Plasma Volume; D012106:Research; D012996:Solutions
D001798:Blood Proteins; D003911:Dextrans; D010952:Plasma Substitutes; D012996:Solutions
BLOOD PROTEINS; BLOOD VOLUME; DEXTRAN; DOGS; EXPERIMENTAL LAB STUDY; HEMATOCRIT; PHARMACOLOGY