PASSIVE TRANSFER OF TRANSPLANTATION IMMUNITY. IV. TRANSPLANTATION ANTIBODY FROM EXTRACTS OF SENSITIZED LYMPHOID CELLS.
Passive transfer of homograft immunity was successfully achieved by injection of the supernatant obtained from tissue-sensitized lymphoid cells disrupted by sonic vibration. The effective substance destroyed specific skin homografts within 6 days but did not reject non-specific skin grafts in this time. No evidence of transferred antigen or of transfer factor was found when the effective material was passed to irradiated recipients carrying test grafts. By a variety of physiochemical procedures the "soluble substance" behaved like a gamma globulin and was considered to be a transplantation antibody.
D000818:Animals; D000906:Antibodies; D007109:Immunity; D008214:Lymphocytes; D008221:Lymphoid Tissue; D051379:Mice; D012106:Research; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D000906:Antibodies
ANTIBODIES; EXPERIMENTAL LAB STUDY; IMMUNITY; LYMPHOID TISSUE; MICE; SKIN TRANSPLANTATION