DRUG-INDUCED CHANGES IN THE LIVER ENDOPLASMIC RETICULUM: ASSOCIATION WITH DRUG-METABOLIZING ENZYMES.
The cellular changes which lead to the increase of drug-metabolizing enzymes following drug administration are explained by correlating new biochemical data with previously reported electron microscopic and pharmacologic observations. Repeated administration of phenobarbital and several other drugs results in a quantitative increase of the smooth endoplasmic reticulum of the liver cell. The marked increase in drug-metabolizing enzymes is found to occur in this enlarged smooth membrane fraction of the endoplasmic reticulum.
D000251:Adenosine Triphosphatases; D000818:Animals; D003580:Cytochromes; D004721:Endoplasmic Reticulum; D008099:Liver / Q000166:cytology* / Q000201:enzymology*; D008620:Meprobamate; D008854:Microscopy, Electron; D009699:N-Glycosyl Hydrolases; D009552:Nikethamide; D009584:Nitrogen; D009966:Orphenadrine; D010600:Pharmacology; D010634:Phenobarbital; D010653:Phenylbutazone; D010744:Phosphoric Monoester Hydrolases; D010758:Phosphorus; D014044:Tolbutamide
D003580:Cytochromes; D010758:Phosphorus; D009552:Nikethamide; D014044:Tolbutamide; D008620:Meprobamate; D009966:Orphenadrine; D010744:Phosphoric Monoester Hydrolases; D009699:N-Glycosyl Hydrolases; D000251:Adenosine Triphosphatases; D010653:Phenylbutazone; D009584:Nitrogen; D010634:Phenobarbital
ADENOSINE TRIPHOSPHATASE; CYTOCHROMES; LIVER CYTOLOGY; LIVER ENZYMOLOGY; MEPROBAMATE; NIKETHAMIDE; NITROGEN; NUCLEOSIDASES; ORPHENADRINE; PHARMACOLOGY; PHENOBARBITAL; PHENYLBUTAZONE; PHOSPHATASES; PHOSPHORUS; TOLBUTAMIDE