RADIATION-INDUCED MOUSE LEUKEMIA: CONSISTENT OCCURRENCE OF AN EXTRA AND A MARKER CHROMOSOME.
Granulocytic leukemia, induced in the primary mouse by x-irradiation, was serially transmitted to RF/Up mice. An extra chromosome, as well as a morphologicaly unusual chromosome, was found in the bone marrow cells of all the leukemic mice that had been injected previously either with leukemic spleen cells or with cell-free ultracentrifugates. This suggests that the changes in the chromosomes are caused by a virus.
D000818:Animals; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D002875:Chromosomes; D007938:Leukemia; D007953:Leukemia, Radiation-Induced; D051379:Mice; D012106:Research; D013154:Spleen; D014965:X-Rays
CHROMOSOME ABNORMALITIES; EXPERIMENTAL LAB STUDY; LEUKEMIA, RADIATION-INDUCED; MICE