LIGHT AND ELECTRON MICROSCOPIC STUDIES OF "MYOGRANULES" IN A CHILD WITH HYPOTONIA AND MUSCLE WEAKNESS.
Examination by light and electron microscopy of more than 100 muscle biopsies revealed one very unusual case. A 4-year-old boy with non-progressive muscle weakness and hypotonia was found to have small particles, termed "myogranules", in many muscle fibres from two gastrocnemius biopsies. Paraffin sections and thin sections of plastic-embedded muscle showed that the rod-shaped myogranules measured between 0.1 and 5 microns in length, and were usually orientated in the long axis of the fibre. Normal cross-striations could not be seen in areas occupied by myogranules, although adjacent parts of the same fibre were normal. Electron micrographs showed myofilaments running through the myogranules and a periodicity similar to sections of recrystallized muscle protein paramyosin. It is possible that this child has a disturbance of muscle proteins.
D008841:Actin Cytoskeleton; D001706:Biopsy; D002648:Child; D004583:Electrons; D006801:Humans; D008297:Male; D008853:Microscopy; D008854:Microscopy, Electron; D009123:Muscle Hypotonia; D009124:Muscle Proteins; D018908:Muscle Weakness; D018482:Muscle, Skeletal; D009132:Muscles; D009135:Muscular Diseases; D009210:Myofibrils; D010291:Paresis; D014335:Tropomyosin
D009124:Muscle Proteins; D014335:Tropomyosin
BIOPSY; CHILD; MICROSCOPY, ELECTRON; MUSCULAR DISEASES