INHIBITION OF ADHESIVENESS AND AGGREGATION OF DISSOCIATED CELLS BY INHIBITORS OF PROTEIN AND RNA SYNTHESIS.
Mutual adhesiveness and aggregation of dissociated embryonic retina cells in suspension cultures are suppressed rapidly and reversibly by puromycin, an inhibitor of RNA-dependent protein synthesis; and at a slower rate, irreversibly, by actinomycin D, an inhibitor of RNA formation. The results imply that biosynthetic processes are involved in the mechanism of reattachment of these cells.
D000268:Adhesiveness; D000900:Anti-Bacterial Agents; D003585:Cell Biology; D002642:Chick Embryo; D003609:Dactinomycin; D010600:Pharmacology; D011506:Proteins / Q000378:metabolism*; D011691:Puromycin; D012313:RNA; D012106:Research; D012160:Retina
D000900:Anti-Bacterial Agents; D011506:Proteins; D003609:Dactinomycin; D011691:Puromycin; D012313:RNA
ACTINOMYCIN; ANTIBIOTICS; CHICK EMBRYO; CYTOLOGY; EXPERIMENTAL LAB STUDY; PHARMACOLOGY; PROTEIN METABOLISM; PUROMYCIN; RETINA; RNA