THE FATE OF DNA-CONTAINING PARTICLES PHAGOCYTIZED BY MAMMALIAN CELLS.
Particulate DNA protein coacervates were digested immediately after being phagocytized by L strain fibroblasts in suspension culture. Enlargement of the phagocytotic vacuoles occurred simultaneously with a loss of the electron opacity of the phagocytized particles. Cytochemical reactions positive for non-specific esterase, acid phosphatase, and nucleoside phosphatase in the phagocytotic vacuoles provided additional evidence for the probability of complete hydrolysis of the phagocytized nucleoprotein.
D000135:Acid Phosphatase; D000227:Adenine Nucleotides; D000251:Adenosine Triphosphatases; D000255:Adenosine Triphosphate; D000818:Animals; D004247:DNA; D004063:Digestion; D004583:Electrons; D004950:Esterases; D008853:Microscopy; D008854:Microscopy, Electron; D009698:Nucleoproteins; D010587:Phagocytosis; D010744:Phosphoric Monoester Hydrolases; D012106:Research; D012107:Research Design; D012270:Ribosomes; D046509:Tissue Culture Techniques
D000227:Adenine Nucleotides; D009698:Nucleoproteins; D000255:Adenosine Triphosphate; D004247:DNA; D004950:Esterases; D000135:Acid Phosphatase; D010744:Phosphoric Monoester Hydrolases; D000251:Adenosine Triphosphatases
ACID PHOSPHATASE; ADENINE NUCLEOTIDES; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; DIGESTION; DNA; ESTERASES; EXPERIMENTAL LAB STUDY; MICROSCOPY, ELECTRON; NUCLEOPROTEINS; PHAGOCYTOSIS; PHOSPHATASES; RIBOSOMES; TISSUE CULTURE