THE CONTROL OF PRECANCEROUS CONDITIONS OF THE COLON AND RECTUM.
The early diagnosis and treatment of precancerous lesions is an important means of control of intestinal cancer. The precancerous tendency is relatively slight with solitary colo-rectal polyps, ulcerative colitis and bilharzial infestation, but it is exceptionally severe in familial colonic polyposis.For more than 30 years, research into the inheritance and treatment of familial polyposis has been continued at St. Mark's Hospital, London, England, and more than 90 families have been investigated and family pedigrees prepared. These now include 1050 "members", of whom 343 have had either polyposis or intestinal cancer, or both, the number with cancer being 243. One hundred and one of these 343 patients have been operated on at St. Mark's, 61 undergoing colectomy and ileorectal anastomosis.Cancer control is achieved by keeping under supervision all members of a family who have already developed polyposis or who may do so later.
D000236:Adenoma; D011125:Adenomatous Polyposis Coli; D000328:Adult; D000714:Anastomosis, Surgical; D003082:Colectomy; D003093:Colitis, Ulcerative; D003110:Colonic Neoplasms; D004739:England; D005826:Genetics, Medical; D006801:Humans; D008131:London; D009369:Neoplasms / Q000209:etiology*; D010212:Papilloma; D011127:Polyps; D011230:Precancerous Conditions; D012004:Rectal Neoplasms; D012007:Rectum; D012552:Schistosomiasis
ADENOMA; COLITIS, ULCERATIVE; COLONIC NEOPLASMS; GENETICS, HUMAN; NEOPLASM ETIOLOGY; PAPILLOMA; POLYPS; RECTAL NEOPLASMS; SCHISTOSOMIASIS