PRACTICAL HUMAN GROWTH HORMONE. PREPARATION AND CLINICAL USE.
Human growth hormone was prepared from acetone-dried pituitary powder by hot glacial acetic acid extraction and subsequent precipitation by sodium chloride and cold acetone. The yield was 13 per cent and the preparation was called practical growth hormone in recognition of its complement of corticotropin. Treatment of two dwarfs with practical growth hormone in aqueous solution, 1 or 2 mg intramuscularly on alternate days, accelerated the growth rate and there were no physical signs or laboratory indications of adrenal stimulation or other adverse effects. The preparation is recommended for its safety, simplicity and relatively good yield.
D000293:Adolescent; D000324:Adrenocorticotropic Hormone; D001774:Blood Chemical Analysis; D055598:Chemical Phenomena; D002621:Chemistry; D004392:Dwarfism; D004393:Dwarfism, Pituitary; D004586:Electrophoresis; D013006:Growth Hormone; D019382:Human Growth Hormone; D006801:Humans; D010336:Pathology; D010900:Pituitary Diseases; D012965:Sodium Chloride
D019382:Human Growth Hormone; D012965:Sodium Chloride; D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone
ADOLESCENCE; BLOOD CHEMICAL ANALYSIS; CHEMISTRY; DWARFISM, PITUITARY; ELECTROPHORESIS; PATHOLOGY; SOMATOTROPIN