GAMMA GLOBULIN TURNOVER IN RABBITS BEFORE AND DURING HYPERIMMUNIZATION.
The turnover of (131)I-labeled gamma globulin has been determined in rabbits before and during (8 weeks later) hyperimmunization with pneumococcic vaccine, which increased the gamma globulin concentration 5 to 10 times. Before immunization fractional turnover rate was an average of 36 per cent of the plasma pool per day, and the rate of catabolism was 133 mg/kg/day. During hyperimmunization fractional turnover rate was an average of 37 per cent per day, and the rate of catabolism was 1160 mg/kg/day. The observation that the fractional turnover rate is independent of the concentration suggests that the rate of breakdown should have the characteristic of a first order process.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens; D007114:Immunization; D007456:Iodine Isotopes; D008660:Metabolism; D011817:Rabbits; D012106:Research; D013296:Streptococcus pneumoniae; D014612:Vaccines; D005719:gamma-Globulins
D000941:Antigens; D007456:Iodine Isotopes; D014612:Vaccines; D005719:gamma-Globulins
ANTIBODY FORMATION; ANTIGENS; DIPLOCOCCUS PNEUMONIAE; EXPERIMENTAL LAB STUDY; GAMMA GLOBULIN; IODINE ISOTOPES; METABOLISM; RABBITS