CITRATE CLEAVAGE ENZYME IN LIVERS OF OBESE AND NONOBESE MICE.
The specific activity of the citrate cleavage enzyme is 3.3 times greater in livers of obese mice than in livers of their nonobese litter mates. The difference persists during starvation. The specific activity of the acetate activating enzyme is approximately the same in the livers of both types of animals. It is proposed that a high activity of citrate cleavage enzyme is one of the factors responsible for obesity.
D001275:ATP Citrate (pro-S)-Lyase; D000085:Acetates; D000227:Adenine Nucleotides; D000255:Adenosine Triphosphate; D000818:Animals; D050260:Carbohydrate Metabolism; D002247:Carbon Isotopes; D002951:Citrates; D003065:Coenzyme A; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology*; D051379:Mice; D008928:Mitochondria; D009765:Obesity; D012106:Research; D013217:Starvation
D000085:Acetates; D000227:Adenine Nucleotides; D002247:Carbon Isotopes; D002951:Citrates; D000255:Adenosine Triphosphate; D001275:ATP Citrate (pro-S)-Lyase; D003065:Coenzyme A
ACETATES; ADENINE NUCLEOTIDES; ADENOSINE TRIPHOSPHATE; CARBOHYDRATE METABOLISM; CARBON ISOTOPES; CITRATES; COENZYME A; EXPERIMENTAL LAB STUDY; LIPID METABOLISM; LIVER ENZYMOLOGY; MICE; MITOCHONDRIA; OBESITY; STARVATION