IMMUNOLOGICALLY DETERMINED AND COMPETENT CELLS ARE AFFECTED DIFFERENTIALLY BY ACTINOMYCIN D.
A differential effect of actinomycin D on the capacity of mouse peritoneal fluid cells to form antibody after cell transfer has been found. Actinomycin treatment in vitro during transfer inhibited the delayed response toward a first antigen, administered before transfer, while the competence of cells to respond to a second antigen, given aftertransfer, was not affected.
D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D003609:Dactinomycin; D051379:Mice; D010600:Pharmacology; D011830:Radiation Effects / Q000276:immunology*; D012106:Research; D013154:Spleen; D014116:Toxicology; D014181:Transplantation Immunology
D003609:Dactinomycin
ACTINOMYCIN; ANTIBODY FORMATION; ANTIGEN-ANTIBODY REACTIONS; EXPERIMENTAL LAB STUDY; MICE; PHARMACOLOGY; RADIATION IMMUNOLOGY; TOXICOLOGIC REPORT; TRANSPLANTATION IMMUNOLOGY