IMMUNOLOGICAL TOLERANCE INDUCED IN ANIMALS PREVIOUSLY SENSITIZED TO SIMPLE CHEMICAL COMPOUNDS.
Adult guinea pigs develop a delayed hypersensitivity to intradermally injected neoarsphenamine. If the animals are treated intravenously with high doses of this compound before sensitization, a specific and permanent immunological tolerance develops. Permanent tolerance is also obtained in previously sensitized animals when an intravenous injection of neoarsphenamine isfollowed 6 hours later by an intradermal one. When, however, the interval between the two injections is extended to 7 or 14 days, no tolerance is observed.
D000818:Animals; D000937:Antigen-Antibody Reactions; D001153:Arsphenamine / Q000031:analogs & derivatives; D003872:Dermatitis; D003877:Dermatitis, Contact; D004361:Drug Tolerance; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D007108:Immune Tolerance; D012106:Research; D014116:Toxicology
D001153:Arsphenamine; C073331:neoarsphenamine
ANTIGEN-ANTIBODY REACTIONS; DERMATITIS, CONTACT; DRUG TOLERANCE; EXPERIMENTAL LAB STUDY; GUINEA PIGS; NEOARSPHENAMINE; TOXICOLOGIC REPORT