HEMOGLOBIN POLYMORPHISM: ITS RELATION TO SICKLING OF ERYTHROCYTES IN WHITE-TAILED DEER.
Hemoglobins with different electrophoretic mobilities are associated with bizarre shapes seen during ordinary light microscopy of erythrocytes from the white-tailed deer, Odocoileus virginianus; nonsickling is contingent upon a specific hemoglobin. Sickling in vitro, which isproduced to a maximum degree in the presence of oxygen and elevated pH, is not associated with hematological abnormalities or disease despite marked differences in physical characteristics of sickled and nonsickled cells.
D000740:Anemia; D000755:Anemia, Sickle Cell; D000818:Animals; D001188:Artiodactyla; D001797:Blood Protein Electrophoresis; D003670:Deer; D004578:Electron Spin Resonance Spectroscopy; D004912:Erythrocytes; D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010100:Oxygen; D011110:Polymorphism, Genetic; D012106:Research
D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; D010100:Oxygen
ANEMIA, SICKLE CELL; ARTIODACTYLA; BLOOD PROTEIN ELECTROPHORESIS; EXPERIMENTAL LAB STUDY; HEMOGLOBINS, ABNORMAL; HYDROGEN-ION CONCENTRATION; OXYGEN