IPROVERATRIL: EXPERIMENTAL DATA ON CORONARY DILATATION AND ANTIARRHYTHMIC ACTION.
Various cardiovascular effects of a new synthetic coronary vasodilator, alpha-isopropyl-alpha [(N-methyl - N - homoveratryl)-gamma-amino-propyl]-3, 4-dimethoxyphenylacetonitrile HCI (D365, Iproveratril or Isoptin) have been studied. In isolated perfused rabbit hearts the drug exerts a potent coronary vasodilator action, but can depress myocardial contractions and A-V conduction. In anesthetized cats it produces varying degrees of hypotension with bradycardia, and antagonizes ST-T changes induced by ouabain. It can also protect against chloroform-adrenaline and ouabain ventricular fibrillation. On isolated papillary muscle preparations it can lead to adrenergic blockade. It is concluded that in addition to its coronary dilator action, the drug exerts ;quinidine-like' antiarrythmic effects, and appears to deserve further study.
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001001:Anura; D001794:Blood Pressure; D001919:Bradycardia; D002415:Cats; D002725:Chloroform; D003331:Coronary Vessels; D004106:Dilatation; D004562:Electrocardiography; D004837:Epinephrine; D006321:Heart; D006339:Heart Rate; D007022:Hypotension; D010042:Ouabain; D010600:Pharmacology; D011802:Quinidine; D011817:Rabbits; D012106:Research; D013328:Strophanthins; D014116:Toxicology; D014665:Vasodilator Agents; D014693:Ventricular Fibrillation; D014700:Verapamil
D000889:Anti-Arrhythmia Agents; D013328:Strophanthins; D014665:Vasodilator Agents; D010042:Ouabain; D002725:Chloroform; D014700:Verapamil; D011802:Quinidine; D004837:Epinephrine
BLOOD PRESSURE; BRADYCARDIA; CATS; CHLOROFORM; CORONARY VESSELS; ELECTROCARDIOGRAPHY; EPINEPHRINE; EXPERIMENTAL LAB STUDY; FROGS; HEART; HYPOTENSION; IPROVERATRIL; MYOCARDIAL DEPRESSANTS; OUABAIN; PHARMACOLOGY; RABBITS; STROPHANTHIN; TOXICOLOGIC REPORT; VASODILATOR AGENTS