PROCAINE ACTION: ANTAGONISM BY ADENOSINE TRIPHOSPHATE AND OTHER NUCLEOTIDES.
Appropriate concentrations of adenosine tri-, di-, and monophosphate antagonize the depressant action of procaine on isolated nerve. Some calcium ion is required in the external solution in order for these nucleotides to produce their maximum effects. When applied either to normal or sodium deficient nerves, the nucleotides do not increase action-potential amplitude.
D000200:Action Potentials; D000227:Adenine Nucleotides; D000241:Adenosine; D000255:Adenosine Triphosphate; D000818:Animals; D001001:Anura; D002118:Calcium; D009417:Nerve Tissue; D009711:Nucleotides; D010600:Pharmacology; D011343:Procaine; D011898:Ranidae; D012106:Research; D012964:Sodium
D000227:Adenine Nucleotides; D009711:Nucleotides; D011343:Procaine; D000255:Adenosine Triphosphate; D012964:Sodium; D000241:Adenosine; D002118:Calcium
ADENINE NUCLEOTIDES; ADENOSINE TRIPHOSPHATE; CALCIUM; EXPERIMENTAL LAB STUDY; FROGS; NERVE TISSUE; PHARMACOLOGY; PROCAINE