SEROTONIN BINDING TO NERVE-ENDING PARTICLES OF THE RAT BRAIN AND ITS INHIBITION BY LYSERGIC ACID DIETHYLAMIDE.
The binding of serotonin to nerve-ending particles and other preparations from rat brain has been examined. By investigating the amount bound as a function of serotonin concentration from 10(-7)M to 1O(-2)M, it was possible to identify three major components having K(assoc) (association constant) values of 2 x 10(6), 5 x 10(4), and 5 x 10(2). The component having the highest binding constant was not present in liver and appeared to be confined to the cortex and midbrain regions. This component is inhibited by d-lysergic acid diethylamide at low concentrations. Solubilization of this binding component has been achieved.
D001921:Brain; D008238:Lysergic Acid Diethylamide; D009411:Nerve Endings; D009448:Neurochemistry; D010600:Pharmacology; D051381:Rats; D012106:Research; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors
D008238:Lysergic Acid Diethylamide; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors
BRAIN; EXPERIMENTAL LAB STUDY; LYSERGIC ACID DIETHYLAMIDE; NERVE ENDINGS; NEUROCHEMISTRY; PHARMACOLOGY; RATS; SEROTONIN; SEROTONIN INHIBITORS