SEROTONIN DEFICIENCY IN INFANCY AS ONE CAUSE OF A MENTAL DEFECT IN PHENYLKETONURIA.
Serotonin deficiency induced in newborn mice and maintained to adulthoodresulted in reduced ability to learn a maze. The serotonin deficiency was produced by overloading with phenylalanine plus tyrosine (to cause phenylketonuria), by feeding of reserpine, and by feeding of chlorpro mazine from birth to maturity.
D000818:Animals; D000831:Animals, Newborn; D001519:Behavior; D002395:Catecholamines; D002746:Chlorpromazine / Q000633:toxicity*; D005823:Genetics; D007858:Learning; D008659:Metabolic Diseases; D008660:Metabolism; D051379:Mice; D010649:Phenylalanine; D010661:Phenylketonurias; D010667:Phenylpyruvic Acids; D012106:Research; D012110:Reserpine / Q000633:toxicity*; D012701:Serotonin; D014116:Toxicology; D014443:Tyrosine
D002395:Catecholamines; D010667:Phenylpyruvic Acids; D012701:Serotonin; D014443:Tyrosine; D010649:Phenylalanine; D012110:Reserpine; D002746:Chlorpromazine; C031606:phenylpyruvic acid
ANIMALS, NEWBORN; BEHAVIOR; CATECHOLAMINES; CHLORPROMAZINE TOXICOLOGY; EXPERIMENTAL LAB STUDY; GENETICS; LEARNING; METABOLIC DISEASES; METABOLISM; MICE; PHENYLALANINE; PHENYLKETONURIA; PHENYLPYRUVIC ACID; RESERPINE TOXICOLOGY; SEROTONIN; TOXICOLOGIC REPORT; TYROSINE