PLURIPOTENT STEM CELL FUNCTION OF THE MOUSE MARROW "LYMPHOCYTE".
Bone marrow from normal and polycythemic mice was filtered through glasswool columns to remove cells other than "lymphocytes." For a given number of nucleated cells, filtered marrow was more efficient than the original marrow in repopulating the spleen of an isogenic recipient previously exposed to lethal irradiation. The proliferative capacity of both the filtered and unfiltered marrow suspensions appeared to be a constant function of the number of small and medium "lymphocytes" present and not of any other cell type.
D000818:Animals; D001853:Bone Marrow; D001854:Bone Marrow Cells; D016026:Bone Marrow Transplantation; D004247:DNA; D004912:Erythrocytes; D007456:Iodine Isotopes; D008214:Lymphocytes; D051379:Mice; D009705:Nucleosides; D039904:Pluripotent Stem Cells; D011086:Polycythemia; D011830:Radiation Effects / Q000276:immunology*; D012106:Research; D013154:Spleen; D013936:Thymidine
D007456:Iodine Isotopes; D009705:Nucleosides; D004247:DNA; D013936:Thymidine
BONE MARROW TRANSPLANTATION; DNA; ERYTHROCYTES; EXPERIMENTAL LAB STUDY; IODINE ISOTOPES; LYMPHOCYTES; MICE; NUCLEOSIDES; POLYCYTHEMIA; RADIATION IMMUNOLOGY; SPLEEN; THYMIDINE