THE EFFECT OF LIPEMIA ON PERIPHERAL BLOOD FLOW.
The effect of lipemia on peripheral blood flow was studied in patients with and without peripheral vascular disease. Blood flow was measured by venous occlusion plethysmography in the calf and/or finger four to six hours after a fatty meal and after intravenous heparin. The abolition of postprandial lipemia by heparin was determined by measuring the plasma lactescence.Heparin resulted in no change in finger flow of either group or in calf flow in the control group. In nine out of 10 patients with occlusive vascular disease of the legs, it resulted in a small but significant increase of calf blood flow. No such alteration was found when heparin was given following a non-fatty meal.In 12 patients with intermittent claudication the clearing of postprandial lipemia by heparin caused prolongation of claudication time, as measured by the appearance of pain on treadmill exercise.It is concluded that, in some cases, postprandial lipemia is associated with a decrease in blood flow in a limb which is already the site of occlusive vascular disease.
D001161:Arteriosclerosis; D035843:Biomedical Research; D001775:Blood Circulation; D001783:Blood Flow Velocity; D002318:Cardiovascular Diseases; D004041:Dietary Fats; D015444:Exercise; D005080:Exercise Test; D005684:Gait; D006439:Hemodynamics; D006801:Humans; D006949:Hyperlipidemias; D007383:Intermittent Claudication; D007866:Leg; D008071:Lipoprotein Lipase; D008297:Male; D010783:Photometry; D010991:Plethysmography; D019518:Postprandial Period
D004041:Dietary Fats; D008071:Lipoprotein Lipase
ARTERIOSCLEROSIS; BLOOD CIRCULATION; BLOOD FLOW VELOCITY; CLINICAL RESEARCH; DIETARY FATS; HYPERLIPEMIA; LIPOPROTEIN LIPASE; PHOTOMETRY; PLETHYSMOGRAPHY