DNA CONTENTS OF CHROMOSOME PH1 AND CHROMOSOME 21 IN HUMAN CHRONIC GRANULOCYTIC LEUKEMIA.
The Philadelphia chromosome, characteristic of chronic granulocytic leukemia, contained 61+/-1 percent as much DNA as a number 21 (or 22) chromosome from which it is believed to be derived. The remaining 39 percent represents 0.5 percent of a diploid chromosome complement, approximately 2 x 10(7) nucleotide pairs; the method used was not sensitive enough to detect whether it had been translocated to other chromosomes.
D002467:Cell Nucleus; D002875:Chromosomes; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D002891:Chromosomes, Human, Pair 21; D004247:DNA; D004273:DNA, Neoplasm; D005823:Genetics; D006801:Humans; D007938:Leukemia; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive; D007951:Leukemia, Myeloid; D009369:Neoplasms; D010336:Pathology; D010677:Philadelphia Chromosome; D011003:Ploidies; D014178:Translocation, Genetic
D004273:DNA, Neoplasm; D004247:DNA
CELL NUCLEUS; CHROMOSOMES; DNA, NEOPLASM; GENETICS; LEUKEMIA, MYELOCYTIC; PATHOLOGY