SYNTHESIS OF RNA IN VITRO STIMULATED IN DIPTERAN SALIVARY GLANDS BY 1,1,3-TRICYANO-2-AMINO-1-PROPENE.
1,1,3-Tricyano-2-amino-1-propene stimulates by more than one order of magnitude the incorporation in vitro of uridine into the RNA of dipteran salivary glands. The inhibition by actinomycin D is blocked. Higher doses cause a complete inhibition from which a proportion of the glands recover rapidly upon withdrawal of the substance.
D000475:Alkenes; D000818:Animals; D013956:Antithyroid Agents; D001345:Autoradiography; D003486:Cyanides; D003609:Dactinomycin; D004175:Diptera; D066298:In Vitro Techniques; D008660:Metabolism; D009570:Nitriles; D009705:Nucleosides; D012313:RNA; D012106:Research; D012469:Salivary Glands; D014316:Tritium; D014529:Uridine
D000475:Alkenes; D013956:Antithyroid Agents; D003486:Cyanides; D009570:Nitriles; D009705:Nucleosides; D014316:Tritium; D003609:Dactinomycin; D012313:RNA; C013658:propylene; C025201:Malononitrile dimer; D014529:Uridine
ACTINOMYCIN; CYANIDES; DIPTERA; EXPERIMENTAL LAB STUDY; METABOLISM; NUCLEOSIDES; RADIOAUTOGRAPHY; RNA; SALIVARY GLANDS; THYROID ANTAGONISTS; TRITIUM