AFFINITY AND PHOSPHORYLATION CONSTANTS FOR THE INHIBITION OF ESTERASES BY ORGANOPHOSPHATES.
Equations based on the assumption of a reversible first step in the reaction between organophosphate inhibitors and esterases are proposed for the bimolecular rate constant which now includes an affinity constant and a phosphorylation constant. The treatment applies when the inhibition reaction follows first-order kinetics.
D055598:Chemical Phenomena; D002621:Chemistry; D002802:Cholinesterases; D004791:Enzyme Inhibitors; D004950:Esterases; D007531:Isoflurophate; D007700:Kinetics; D062025:Organophosphate Poisoning; D010755:Organophosphates; D010758:Phosphorus; D010766:Phosphorylation; D011042:Poisons; D012106:Research
D004791:Enzyme Inhibitors; D010755:Organophosphates; D011042:Poisons; D007531:Isoflurophate; D010758:Phosphorus; D004950:Esterases; D002802:Cholinesterases
CHEMISTRY; CHOLINESTERASE; ENZYME INHIBITORS; ESTERASES; EXPERIMENTAL LAB STUDY; ISOFLUROPHATE; PHOSPHORUS POISONS, ORGANIC