GAMMA-GLOBULIN AFFINITY FOR NORMAL HUMAN TISSUE OF THE CENTRAL NERVOUS SYSTEM.
Immunofluorescent staining of the serum and cerebrospinal fluid of patients with and without neurological disease demonstrates an affinity of the gamma-globulin fraction for glial cells and myelin sheaths in normal human nervous tissue. This affinity appears to be specific for the 7S gamma-globulin fraction and is not seen with the other major protein fractions of serum and cerebrospinal fluid or with the fluorescein conjugated antisera alone.
D000690:Amyotrophic Lateral Sclerosis; D001932:Brain Neoplasms; D002490:Central Nervous System; D002555:Cerebrospinal Fluid; D002561:Cerebrovascular Disorders; D003711:Demyelinating Diseases; D006801:Humans; D007074:Immunoglobulin G; D009103:Multiple Sclerosis; D009186:Myelin Sheath; D009422:Nervous System Diseases; D009457:Neuroglia; D020734:Parkinsonian Disorders; D005719:gamma-Globulins
D007074:Immunoglobulin G; D005719:gamma-Globulins
AMYOTROPHIC LATERAL SCLEROSIS; BRAIN NEOPLASMS; CEREBROSPINAL FLUID; CEREBROVASCULAR DISORDERS; DEMYELINATION; GAMMA GLOBULIN; MULTIPLE SCLEROSIS; MYELIN SHEATH; NEUROGLIA; PARKINSONISM