ESTRONE INHIBITION OF CHOLESTEROL BIOSYNTHESIS AT THE MEVALONIC ACID STAGE.
Studies on the synthesis of cholesterol with cell-free homogenates of liver from rats treated with graded doses of estrone show that, at doses of estrone which cause a reduction in blood cholesterol, there is an accompanying inhibition of cholesterol biosynthesis. Furthermore, this inhibition appears to occur at the stage of cholesterol biosynthesis at which mevalonate is decarboxylated.
D001669:Biochemical Phenomena; D001671:Biochemistry; D002247:Carbon Isotopes; D002784:Cholesterol / Q000097:blood*; D004970:Estrone; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology*; D008798:Mevalonic Acid; D011874:Radiometry; D051381:Rats; D012106:Research; D013261:Sterols; D014116:Toxicology
D002247:Carbon Isotopes; D013261:Sterols; D004970:Estrone; D002784:Cholesterol; D008798:Mevalonic Acid
BIOCHEMISTRY; BLOOD CHOLESTEROL; CARBON ISOTOPES; CHOLESTEROL; ESTRONE; EXPERIMENTAL LAB STUDY; LIPID METABOLISM; LIVER ENZYMOLOGY; MEVALONIC ACID; RADIOMETRY; RATS; STEROLS; TOXICOLOGIC REPORT