PHENETHYL ALCOHOL SYNERGISM WITH MITOMYCIN C, PORFIROMYCIN, AND STREPTONIGRIN.
Cyanide and phenethyl alcohol greatly enhance the lethal action of mitomycin C, porfiromycin, and streptonigrin on an exponentially growing culture of Escherichia coli. Dinitrophenol similarly enhances the lethal action of mitomycin C and porfiromycin, but only slightly that of streptonigrin. Phenethyl alcohol may be functioning in these experiments as an inhibitor of electron transport.
D000438:Alcohols; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D003486:Cyanides; D004926:Escherichia coli; D016685:Mitomycin; D010600:Pharmacology; D010636:Phenols; D010626:Phenylethyl Alcohol; D011160:Porfiromycin; D012106:Research; D013308:Streptonigrin
D000438:Alcohols; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D003486:Cyanides; D010636:Phenols; D013308:Streptonigrin; D016685:Mitomycin; D011160:Porfiromycin; D010626:Phenylethyl Alcohol
ALCOHOLS; ANTIBIOTICS; ANTINEOPLASTIC AGENTS; CYANIDES; ESCHERICHIA COLI; EXPERIMENTAL LAB STUDY; MITOMYCIN; PHARMACOLOGY; PHENOLS