SKIN TUMORIGENESIS BY 7,12-DIMETHYLBENZ(A)ANTHRACENE: INHIBITION BY ACTINOMYCIN D.
Topical application of actinomycin D during a short period of time immediately before and after a single application of 7, 12-dimethyl-benz (a)anthracene markedly inhibits subsequent tumor formation. The results indicate that the initial events of carcinogenesis are dependent on DNA-dependent RNA synthesis.
D000818:Animals; D000873:Anthracenes; D000970:Antineoplastic Agents; D001551:Benz(a)Anthracenes; D063646:Carcinogenesis; D002273:Carcinogens; D003609:Dactinomycin; D051379:Mice; D009374:Neoplasms, Experimental; D010600:Pharmacology; D012106:Research; D012878:Skin Neoplasms; D014116:Toxicology
D000873:Anthracenes; D000970:Antineoplastic Agents; D001551:Benz(a)Anthracenes; D002273:Carcinogens; D003609:Dactinomycin; C030935:benz(a)anthracene; C034020:anthracene
ACTINOMYCIN; ANTINEOPLASTIC AGENTS; BENZANTHRACENES; CARCINOGENS; EXPERIMENTAL LAB STUDY; MICE; PHARMACOLOGY; SKIN NEOPLASMS; TOXICOLOGIC REPORT