AUDIOGENIC SEIZURES, THE DILITE LOCUS, AND PHENYLALANINE HYDROXYLASE IN DBA/1 MICE.
Reduced audiogenic seizure susceptibility in dilute mice was associated with enhancement of phenylalanine hydroxylase activity, previously reported as low in dilute mice. Though nutritional changes complicate the interpretation, evidence exists for a mutation linked with dilute which modifies susceptibility.
D000818:Animals; D008099:Liver / Q000201:enzymology*; D051379:Mice; D008811:Mice, Inbred DBA; D006899:Mixed Function Oxygenases; D009154:Mutation; D010649:Phenylalanine; D010651:Phenylalanine Hydroxylase; D012106:Research; D012640:Seizures; D013016:Sound
D010649:Phenylalanine; D006899:Mixed Function Oxygenases; D010651:Phenylalanine Hydroxylase
CONVULSIONS; EXPERIMENTAL LAB STUDY; HYDROXYLASES; LIVER ENZYMOLOGY; MICE; MUTATION; PHENYLALANINE; SOUND