STRUCTURAL DIFFERENCES BETWEEN 2 TYPES OF "HEAVY CHAIN" DISEASE PROTEINS AND MYELOMA GLOBULINS OF CORRESPONDING TYPES.
Structural differences between two antigenic types (designated C and Z) of gamma-globulins, both of low molecular weight, produced in " Heavy chain" disease are revealed by their relative susceptibilities to enzymatic degradation by papain and the nature of the cleavage products. Corresponding structural differences exist between the respective type C and type Z myeloma gamma(2)-globulins. These structural differences are tentatively assigned to the H-chains, and more specifically to the portion of the H-chain contained in the fast-moving (F) fragment of papain-treated gamma(2)-globulins.
D001669:Biochemical Phenomena; D001671:Biochemistry; D001796:Blood Protein Disorders; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D009101:Multiple Myeloma; D010206:Papain; D012106:Research; D005719:gamma-Globulins
D005719:gamma-Globulins; D010206:Papain
BIOCHEMISTRY; BLOOD PROTEIN DISORDERS; EXPERIMENTAL LAB STUDY; GAMMA GLOBULIN; GEL DIFFUSION TESTS; IMMUNOELECTROPHORESIS; MULTIPLE MYELOMA; PAPAIN