title: DISTRIBUTIVE PAIRING AND ANEUPLOIDY IN MAN.
abstract: The extrapolation of the "distributive-pairing hypothesis" of meiosis in Drosophila melanogaster females to human gametogenesis is proposed to account for the co-occurrence of rare karyotype abnormalities in human families. A description of the hypothesis is presented with its application to some established cases in the cytogenetic literature.
mesh_terms: D000782:Aneuploidy; D000818:Animals; D002869:Chromosome Aberrations; D003582:Cytogenetics; D004314:Down Syndrome; D004330:Drosophila; D004331:Drosophila melanogaster; D005260:Female; D005826:Genetics, Medical; D006801:Humans; D008297:Male; D008540:Meiosis; D012106:Research
keywords: CHROMOSOME ABNORMALITIES; DROSOPHILA; EXPERIMENTAL LAB STUDY; GENETICS, HUMAN; MONGOLISM