HOMOGRAFT TARGET CELLS: SPECIFIC DESTRUCTION IN VITRO BY CONTACT INTERACTION WITH IMMUNE MACROPHAGES.
Specific adherence and mutual immunologic destruction occurred after contact in vitro of immune peritoneal macrophages from C57BI/6K mice with homograft target cells from A/Jax mice. Cell destruction apparently resulted from a nonphagocytic mechanism involving cell contact rather than humoral antibody. Cell destruction was determined by a plaque technique with either immunecells or target cells as monolayers.
D064591:Allografts; D000818:Animals; D000906:Antibodies; D005347:Fibroblasts; D066298:In Vitro Techniques; D007739:L Cells; D008264:Macrophages; D051379:Mice; D008815:Mice, Inbred Strains; D009369:Neoplasms; D010537:Peritoneum; D012106:Research; D012509:Sarcoma; D012513:Sarcoma, Experimental; D046509:Tissue Culture Techniques; D014180:Transplantation; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000906:Antibodies
EXPERIMENTAL LAB STUDY; FIBROBLASTS; L CELLS; MACROPHAGES; MICE; PERITONEUM; SARCOMA, EXPERIMENTAL; TISSUE CULTURE; TRANSPLANTATION; TRANSPLANTATION IMMUNOLOGY