SUBCLASSES OF HUMAN GAMMA-2-GLOBULIN BASED ON DIFFERENCES IN THE HEAVY POLYPEPTIDE CHAINS.
Three subclasses of human gamma(2)-globulin (IgG) molecules were detected in normal human serum with antiserums prepared in monkeys. These subclasses, designated gamma(2a)-, gamma(2b)-, and gamma(2c)-globulins, have antibody activity. The distinguishing antigenic characteristics of each subclass were associated with the heavy polypeptide chains and the F (fast) fragments resulting from treatment of gamma(2)-globulins with papain.
D000941:Antigens; D006801:Humans; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D009101:Multiple Myeloma; D010455:Peptides; D011233:Precipitin Tests; D012106:Research; D005719:gamma-Globulins
D000941:Antigens; D010455:Peptides; D005719:gamma-Globulins
ANTIGENS; EXPERIMENTAL LAB STUDY; GAMMA GLOBULIN; GEL DIFFUSION TESTS; IMMUNOELECTROPHORESIS; PEPTIDES; PRECIPITIN TESTS