THERAPEUTIC ANTIVIRAL ACTION OF 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE IN HERPES SIMPLEX KERATITIS.
5-Trifluoromethyl-2'-deoxyuridine (F(3)TDR) has potent therapeutic antiviral activity in herpes simplex infection of the rabbit cornea with strains of herpes virus both sensitive and resistant to 5-iodo-2'-deoxyuridine, and in corneal infection with vaccinia. 5-Trifluoromethyl uracil is not therapeutically active in herpetic keratitis.
D000818:Animals; D000998:Antiviral Agents; D003315:Cornea; D003320:Corneal Ulcer; D007065:Idoxuridine / Q000031:analogs & derivatives; D007634:Keratitis; D007635:Keratitis, Dendritic; D016849:Keratitis, Herpetic; D010600:Pharmacology; D011817:Rabbits; D012106:Research; D014271:Trifluridine; D014456:Ulcer; D014615:Vaccinia; D014616:Vaccinia virus
D000998:Antiviral Agents; C029954:5'-deoxy-5'-iodouridine; D007065:Idoxuridine; D014271:Trifluridine
ANTIVIRAL AGENTS; CORNEA; CORNEAL ULCER; EXPERIMENTAL LAB STUDY; IDOXURIDINE; KERATITIS, DENDRITIC; PHARMACOLOGY; RABBITS; ULCER; VACCINIA