PYRUVATE METABOLISM AND CONTROL: FACTORS AFFECTING PYRUVIC CARBOXYLASE ACTIVITY.
Pyruvic carboxylase activated by acetyl coenzyme A is highly active in the mitochondria of rodent liver, and its activity is increased in fasting and alloxan diabetes. In conjunction with acyl carboxylase activated by di- and tricarboxylic acid, it forms a reciprocating control network. Analog models of similar networks tend to correct for perturbations, stabilizing the overall system.
D000818:Animals; D002245:Carbon Dioxide; D002247:Carbon Isotopes; D003065:Coenzyme A; D003921:Diabetes Mellitus, Experimental; D001330:Electronic Data Processing; D005215:Fasting; D007328:Insulin; D049528:Insulin, Long-Acting; D008025:Ligases; D008099:Liver / Q000166:cytology* / Q000201:enzymology*; D051379:Mice; D008928:Mitochondria; D011479:Protamines; D011773:Pyruvates; D019289:Pyruvic Acid; D051381:Rats; D012106:Research; D014116:Toxicology
D002247:Carbon Isotopes; D007328:Insulin; D049528:Insulin, Long-Acting; D011479:Protamines; D011773:Pyruvates; C065206:protamine zinc; D002245:Carbon Dioxide; D019289:Pyruvic Acid; D008025:Ligases; D003065:Coenzyme A
ALLOXAN DIABETES; AUTOMATIC DATA PROCESSING; CARBON DIOXIDE; CARBON ISOTOPES; COENZYME A; EXPERIMENTAL LAB STUDY; FASTING; INSULIN, PROTAMINE ZINC; LIGASES; LIVER CYTOLOGY; LIVER ENZYMOLOGY; MICE; MITOCHONDRIA; PYRUVATES; RATS; TOXICOLOGIC REPORT