TUMOR-PROMOTING ACTIVITY OF EXTRACTS OF UNBURNED TOBACCO.
Both an aqueous Balpha(OH)(2) extract and an acetone-benzene extract of unburned cigarette tobacco produced skin tumors when painted on mice previously treated with 125 microg of7,12-dimethylbenz[a]anthracene. The extract from as little as 0.5 cigarette per day was effective. The data are of interest in connection with epidemiological evidence that tobacco chewing is a cause of oral cancer. The data also suggest that tumor-promoting agents in cigarette smokemay have their source in the unburned tobacco
D000818:Animals; D001464:Barium; D001551:Benz(a)Anthracenes; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic; D006878:Hydroxides; D051379:Mice; D009062:Mouth Neoplasms; D009369:Neoplasms; D009374:Neoplasms, Experimental; D010212:Papilloma; D010600:Pharmacology; D012106:Research; D012878:Skin Neoplasms; D014020:Tissue Extracts; D014026:Nicotiana
D001551:Benz(a)Anthracenes; D002273:Carcinogens; D006878:Hydroxides; D014020:Tissue Extracts; D001464:Barium; C030935:benz(a)anthracene
BARIUM; BENZANTHRACENES; CARCINOGENS; EXPERIMENTAL LAB STUDY; HYDROXIDES; MICE; MOUTH NEOPLASMS; NEOPLASMS, EXPERIMENTAL; PAPILLOMA; PHARMACOLOGY; SKIN NEOPLASMS; TISSUE EXTRACTS; TOBACCO