POLYDACTYLISM IN THE OFFSPRING OF MICE INJECTED WITH 5-BROMODEOXYURIDINE.
The intraperitoneal injection of multiple doses of 5-bromodeoxyuridine (BUDR) into pregnant mice produced abnormalities limited to the hind limbs of the offspring. This effect is probably a result of a metabolic lesion. When injected into newborn mice, BUDR did not increase the incidence of tumors.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D001774:Blood Chemical Analysis; D001973:Bromodeoxyuridine; D005190:Family; D005260:Female; D005472:Fluorouracil; D005528:Foot; D005534:Foot Diseases; D006801:Humans; D051379:Mice; D009705:Nucleosides; D017689:Polydactyly; D011247:Pregnancy; D011270:Pregnancy, Animal; D012106:Research; D014116:Toxicology
D009705:Nucleosides; D001973:Bromodeoxyuridine; D005472:Fluorouracil
ABNORMALITIES, DRUG-INDUCED; BLOOD CHEMICAL ANALYSIS; BROMODEOXYURIDINE; EXPERIMENTAL LAB STUDY; FLUOROURACIL; FOOT; FOOT DISEASES; MICE; NUCLEOSIDES; PREGNANCY; PREGNANCY, ANIMAL; TOXICOLOGIC REPORT