PRELIMINARY REPORT ON AN IRON-SORBITOL-CITRIC ACID COMPLEX (JECTOFER), A NEW INTRAMUSCULAR IRON PREPARATION.
One hundred and twenty-eight patients with iron deficiency anemia were treated with a new intramuscular iron preparation, iron-sorbitol-citric acid. One group of 10 patients received a total of 1000 mg. each of elemental iron intramuscularly. All obtained a rise in hemoglobin of over 2.1 g. %, an elevation of serum iron, and a reticulocyte response over 6%. A second larger group of subjects consisted of 113 prenatal and five gynecologic patients; these received an average total dose of 1050 mg. and 1020 mg., respectively, and the average increase in hemoglobin ranged from 1.6 g. % to 2.5 g. %.None of the patients developed significant side effects after injection or permanent staining at the site of injection. Three patients experienced a transient ache at the injection site, and three developed local urticaria-like reactions lasting 24 hours.This new preparation appears to be a safe and clinically effective therapeutic agent in situations in which parenteral iron is indicated.
D000740:Anemia; D000747:Anemia, Hypochromic; D018798:Anemia, Iron-Deficiency; D002951:Citrates; D019343:Citric Acid; D004338:Drug Combinations; D004358:Drug Therapy; D005290:Ferric Compounds; D006454:Hemoglobins; D006801:Humans; D007273:Injections, Intramuscular; D007501:Iron; D013012:Sorbitol; D014116:Toxicology
D002951:Citrates; D004338:Drug Combinations; D005290:Ferric Compounds; D006454:Hemoglobins; C008170:citric acid, iron, sorbitol drug combination; D019343:Citric Acid; D013012:Sorbitol; D007501:Iron
ANEMIA, HYPOCHROMIC; CITRATES; DRUG THERAPY; INJECTIONS, INTRAMUSCULAR; IRON; SORBITOL; TOXICOLOGIC REPORT