title: FLUORIDE: ITS EFFECTS ON 2 PARAMETERS OF BONE GROWTH IN ORGAN CULTURE.
abstract: Bones of the forepaws of young rats were subjected to varying concentrations of fluoride ions in organ culture. The formation of DNA and protein synthesis were evaluated by measurements of the uptake of tritiated thymidine and C(14)-labeled proline. Fluoride concentrations as high as 10 to 20 parts per million had no demonstrable effect in vitro on these basic parameters of skeletal growth
mesh_terms: D001345:Autoradiography; D001846:Bone Development; D001842:Bone and Bones; D002247:Carbon Isotopes; D002455:Cell Division; D004247:DNA; D004838:Epiphyses; D005459:Fluorides; D008663:Metacarpus; D009924:Organ Culture Techniques; D010600:Pharmacology; D010710:Phosphates; D011392:Proline; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D012106:Research; D013936:Thymidine; D046509:Tissue Culture Techniques; D014316:Tritium
chemical_list: D002247:Carbon Isotopes; D010710:Phosphates; D011506:Proteins; D014316:Tritium; C012980:fluorophosphate; D004247:DNA; D011392:Proline; D005459:Fluorides; D013936:Thymidine
keywords: BONE AND BONES; CARBON ISOTOPES; CELL DIVISION; DNA; EPIPHYSES; EXPERIMENTAL LAB STUDY; FLUORIDES; METACARPUS; PHARMACOLOGY; PROLINE; PROTEIN METABOLISM; RADIOAUTOGRAPHY; RATS; THYMIDINE; TISSUE CULTURE; TRITIUM