NICOTONIC ACID BIOSYNTHESIS: CONTROL BY AN ENZYME THAT COMPETES WITH A SPONTANEOUS REACTION.
Extracts of livers from diabetic rats contain normal amounts of the enzymes needed to convert 3-hydroxyanthranilic acid to nicotinic acid nucleotide. The decreased capacity of diabetic animals to synthesize nicotinic acid is therefore attributed to increased amounts of picolinic carboxylase, which competes for a common intermediate with the spontaneous reaction in which quinolinic acid is formed as a precursor of nicotinic acid. These studies were facilitated by the synthesis of 3-hydroxyanthranilic acid labeled with carbon-14 in positions 3 and 6
D000255:Adenosine Triphosphate; D000818:Animals; D002245:Carbon Dioxide; D002247:Carbon Isotopes; D002250:Carbon Radioisotopes; D002262:Carboxy-Lyases; D003921:Diabetes Mellitus, Experimental; D011756:Diphosphates; D008099:Liver / Q000201:enzymology*; D008110:Liver Extracts; D008365:Manometry; D008660:Metabolism; D009525:Niacin; D009539:Nicotinic Acids; D010088:Oxidoreductases; D010600:Pharmacology; D011725:Pyridines; D051381:Rats; D012106:Research; D062367:ortho-Aminobenzoates
D002247:Carbon Isotopes; D002250:Carbon Radioisotopes; D011756:Diphosphates; D008110:Liver Extracts; D009539:Nicotinic Acids; D011725:Pyridines; D062367:ortho-Aminobenzoates; C031385:anthranilic acid; D002245:Carbon Dioxide; D009525:Niacin; D000255:Adenosine Triphosphate; D010088:Oxidoreductases; D002262:Carboxy-Lyases
ADENOSINE TRIPHOSPHATE; ALLOXAN DIABETES; ANTHRANILIC ACID; CARBON DIOXIDE; CARBON ISOTOPES; CARBOXY-LYASES; EXPERIMENTAL LAB STUDY; LIVER ENZYMOLOGY; LIVER EXTRACTS; MANOMETRY; METABOLISM; NICOTINIC ACID; OXIDOREDUCTASES; PHARMACOLOGY; PYRIDINES; PYROPHOSPHATES; RATS