title: TEMPERATURE DEPENDENCE OF ANESTHESIA IN GOLDFISH.
abstract: The anesthetizing concentrations in water of diethyl ether, chloroform, halothane (CF(3)CClBrH), and methaxyflurane (CHCl(2)CF(2)OCH(3)) have been determined for temperature-acclimated goldfish (Carassius auratus) at 5 degrees to 30 degrees C. At 20 degrees C, the concentrations that anesthetize 50 percent of the fish are 2160, 167, 76.4, and 57.0 mg/ liter, respectively; the corresponding partial pressures are 13.0, 3.36, 4.12, and 0.67 mm-Hg. The anesthetizing partial pressures increase with body temperature, with enthalpies of 8.6, 13.2, 12.5, and 12.3 kcal/ mole, respectively.
mesh_terms: D000758:Anesthesia; D000777:Anesthetics; D000818:Animals; D002725:Chloroform; D004986:Ether; D004987:Ethers; D005399:Fishes; D006054:Goldfish; D006221:Halothane; D008733:Methoxyflurane; D010313:Partial Pressure; D010600:Pharmacology; D012106:Research; D013696:Temperature; D014867:Water
chemical_list: D000777:Anesthetics; D004987:Ethers; D014867:Water; D004986:Ether; D008733:Methoxyflurane; D002725:Chloroform; D006221:Halothane
keywords: ANESTHETICS; CHLOROFORM; ETHYL ETHER; EXPERIMENTAL LAB STUDY; FISHES; HALOTHANE; METHOXYFLURANE; PARTIAL PRESSURE; PHARMACOLOGY; TEMPERATURE