URIC ACID TRANSPORT SYSTEM: APPARENT ABSENCE IN ERYTHROCYTES OF THE DALMATIAN COACH HOUND.
The Dalmatian coach hound appears to lack a mediated transport system for uric acid, which can be demonstrated in the erythrocytes of other dogs by hypoxanthine inhibition of uric acid uptake. This transport deficiency may be a manifestation of a genetic defect which has different metabolic consequences in the liver, in the kidney, and in other tissues, depending on the direction of their differentiation
D000818:Animals; D001692:Biological Transport; D002247:Carbon Isotopes; D004285:Dogs; D004912:Erythrocytes; D005823:Genetics; D007042:Hypoxanthines; D007159:Immunologic Tests; D017136:Ion Transport; D007668:Kidney; D007684:Kidney Tubules; D008099:Liver; D008659:Metabolic Diseases; D010600:Pharmacology; D012106:Research; D046509:Tissue Culture Techniques; D014527:Uric Acid; D014970:Xanthines
D002247:Carbon Isotopes; D007042:Hypoxanthines; D014970:Xanthines; D014527:Uric Acid
BIOLOGICAL TRANSPORT; CARBON ISOTOPES; DOGS; ERYTHROCYTES; EXPERIMENTAL LAB STUDY; GENETICS; HYPOXANTHINES; KIDNEY TUBULES; LIVER; METABOLIC DISEASES; PHARMACOLOGY; TISSUE CULTURE; URIC ACID; XANTHINES