MYELOMATOSIS WITH XANTHOMATOSIS MULTIFORME.
A 45-year-old man developed, apparently simultaneously, two rare conditions, xanthomatosis (with hypercholesterolemia) and myelomatosis. His blood contained very high levels of cholesterol, the major part of which was present in a markedly elevated beta-lipoprotein fraction. Studies carried out over a period of six years, utilizing electrophoresis, ultracentrifugation, determinations of chemical composition and incorporation with C(14)-labelled glutamic acid and acetate, indicated a direct association between the two conditions, the myeloma lipoprotein apparently being produced by the abnormal plasma cells in the bone marrow. There were definite indications that the low density S(f) 0-12 lipoproteins were primarily involved.
D001774:Blood Chemical Analysis; D001797:Blood Protein Electrophoresis; D001856:Bone Marrow Examination; D002784:Cholesterol; D004586:Electrophoresis; D005598:Fractures, Spontaneous; D006801:Humans; D006937:Hypercholesterolemia; D008074:Lipoproteins; D008077:Lipoproteins, LDL; D008297:Male; D009101:Multiple Myeloma; D010950:Plasma Cells; D011859:Radiography; D014461:Ultracentrifugation; D014973:Xanthomatosis
D008074:Lipoproteins; D008077:Lipoproteins, LDL; D002784:Cholesterol
BLOOD CHEMICAL ANALYSIS; BLOOD PROTEIN ELECTROPHORESIS; BONE MARROW EXAMINATION; FRACTURES, SPONTANEOUS; HYPERCHOLESTEREMIA; LIPOPROTEINS; MULTIPLE MYELOMA; RADIOGRAPHY; XANTHOMATOSIS