VITAMIN K INDUCED PROTHROMBIN FORMATION: ANTAGONISM BY ACTINOMYCIN D.
Actinomycin D inhibits vitamin K induced formation of prothrombin in chicks deficient in vitamin K. The administration of actinomycin in doses which inhibit prothrombin formation also inhibits synthesis in the liver of RNA from adenosine triphosphate as detected with adenine-8-C1(4). The results are consistent with a genetic action of vitamin K in inducing RNA formation for the synthesis of clotting proteins
D000225:Adenine; D000227:Adenine Nucleotides; D000255:Adenosine Triphosphate; D000818:Animals; D000963:Antimetabolites; D002247:Carbon Isotopes; D003609:Dactinomycin; D008099:Liver; D008660:Metabolism; D009285:Naphthoquinones; D010600:Pharmacology; D011200:Poultry; D011506:Proteins / Q000378:metabolism*; D011516:Prothrombin; D011517:Prothrombin Time; D012313:RNA; D012106:Research; D014812:Vitamin K; D014813:Vitamin K Deficiency
D000227:Adenine Nucleotides; D000963:Antimetabolites; D002247:Carbon Isotopes; D009285:Naphthoquinones; D011506:Proteins; D014812:Vitamin K; D003609:Dactinomycin; D012313:RNA; D000255:Adenosine Triphosphate; D011516:Prothrombin; D000225:Adenine
ACTINOMYCIN; ADENINE; ADENINE NUCLEOTIDES; ADENOSINE TRIPHOSPHATE; ANTIMETABOLITES; CARBON ISOTOPES; EXPERIMENTAL LAB STUDY; LIVER; METABOLISM; NAPHTHOQUINONES; PHARMACOLOGY; POULTRY; PROTEIN METABOLISM; PROTHROMBIN TIME; RNA; VITAMIN K DEFICIENCY