FETAL DEATH FROM NICOTINAMIDE-DEFICIENT DIET AND ITS PREVENTION BY CHLORPROMAZINE AND IMIPRAMINE.
Feeding a diet deficient in nicotinamide, nicotinic acid, and tryptophan to pregnant rats causes death and resorption of all fetuses. This effect can be prevented by administration of either chlorpromazine or imipramine. Analysis of maternal liver at the time of fetal resorption indicates that the observed effects may be mediated through modification of the concentration of the pyridine nucleotide coenzymes.
D000818:Animals; D001361:Avitaminosis; D002746:Chlorpromazine; D004032:Diet; D005260:Female; D005313:Fetal Death; D005333:Fetus; D007099:Imipramine; D008099:Liver; D009243:NAD; D009525:Niacin; D009536:Niacinamide; D009539:Nicotinic Acids; D010600:Pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D012106:Research; D014364:Tryptophan
D009539:Nicotinic Acids; D009243:NAD; D009536:Niacinamide; D009525:Niacin; D014364:Tryptophan; D007099:Imipramine; D002746:Chlorpromazine
AVITAMINOSIS; CHLORPROMAZINE; EXPERIMENTAL LAB STUDY; FETAL DEATH; IMIPRAMINE; NAD; NICOTINAMIDE; NICOTINIC ACID; PHARMACOLOGY; PREGNANCY; PREGNANCY, ANIMAL; RATS; TRYPTOPHAN