ALKYLATION OF SYNTHETIC POLYNUCLEOTIDES.
The synthetic polynucleotides may be used as models for the effects of alkylating agents on nucleic acid. Alkylation of polyadenylic acid with methyl methanesulfonate yields a polymer methylated in the one-position of adenine. This alteration in structure produces marked changes in physical properties and decreases the capacity to code for polylysine synthesis.
D000477:Alkylating Agents; D000478:Alkylation; D000970:Antineoplastic Agents; D055598:Chemical Phenomena; D002621:Chemistry; D009696:Nucleic Acids; D010455:Peptides; D011119:Polynucleotides; D011506:Proteins / Q000378:metabolism*; D012106:Research; D013057:Spectrum Analysis
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D009696:Nucleic Acids; D010455:Peptides; D011119:Polynucleotides; D011506:Proteins
ALKYLATING AGENTS; ALKYLATION; ANTINEOPLASTIC AGENTS; CHEMISTRY; EXPERIMENTAL LAB STUDY; PEPTIDES; POLYNUCLEOTIDES; PROTEIN METABOLISM; SPECTRUM ANALYSIS