THALIDOMIDE: EFFECTS ON EHRLICH ASCITES TUMOR CELLS IN VITRO.
Thalidomide did not inhibit dehydrogenase activity or growth of Ehrlich ascites tumor cells in agar. When mixed with Ehrlich ascites tumor cells in vitro, thalidomide increased the mitotic activity. The effect of the thalidomide was not altered by the addition of nicotinic or folic acid, or by vitamin B(1) or B(6). Oxygen uptake by the tumor cells was not affected by thalidomide.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor; D002455:Cell Division; D005492:Folic Acid; D066298:In Vitro Techniques; D008660:Metabolism; D009525:Niacin; D010088:Oxidoreductases; D010600:Pharmacology; D011736:Pyridoxine; D012106:Research; D012107:Research Design; D013792:Thalidomide; D013831:Thiamine; D046509:Tissue Culture Techniques
D009525:Niacin; D013792:Thalidomide; D005492:Folic Acid; D010088:Oxidoreductases; D011736:Pyridoxine; D013831:Thiamine
CARCINOMA, EHRLICH TUMOR; CELL DIVISION; EXPERIMENTAL LAB STUDY; FOLIC ACID; METABOLISM; NICOTINIC ACID; OXIDOREDUCTASES; PHARMACOLOGY; PYRIDOXINE; THALIDOMIDE; THIAMINE; TISSUE CULTURE