title: MODERN ASPECTS OF THE TREATMENT OF HEMOPHILIA. III.
abstract: In a previous article modifications were proposed in the preparation of the so-called two-donor fibrinogen, used in the treatment of patients suffering from hemophilia A. Only the freshly prepared product could be used, as lyophilization by the usual method caused varying, and at times considerable, losses in Factor VIII activity.In the present communication a method is described for lyophilization of the product by which the advantageous properties of the modified two-donor fibrinogen can be retained for a longer period. Factor VIII activity of this dried product was found to be nearly unchanged after storage for several months.
mesh_terms: D003029:Coagulants; D005169:Factor VIII; D005340:Fibrinogen; D005612:Freeze Drying; D006467:Hemophilia A; D006490:Hemostatics; D006801:Humans
chemical_list: D003029:Coagulants; D006490:Hemostatics; D005169:Factor VIII; D005340:Fibrinogen
keywords: FIBRINOGEN; FREEZE DRYING; HEMOPHILIA