ATROPHY OF SKELETAL MUSCLE IN CHICK EMBRYOS TREATED WITH BOTULINUM TOXIN.
Botulinum toxin was given in large intravenous doses to 7- and 12- day chick embryos. Atrophy of skeletal muscle resulted without significant atrophy of other organs. The histological appearance of muscle was consistent with denervation. The results suggest that neural acetylcholine release may play a significant role in "trophic transmission" from nerve to muscle.
D000014:Abnormalities, Drug-Induced; D000109:Acetylcholine; D000992:Antitoxins; D001905:Botulinum Toxins; D002642:Chick Embryo; D003014:Clostridium botulinum; D007592:Joint Diseases; D018482:Muscle, Skeletal; D009132:Muscles; D009133:Muscular Atrophy; D009469:Neuromuscular Junction; D010336:Pathology; D012106:Research; D014116:Toxicology; D014118:Toxins, Biological
D000992:Antitoxins; D014118:Toxins, Biological; D001905:Botulinum Toxins; D000109:Acetylcholine
ABNORMALITIES, DRUG-INDUCED; ACETYLCHOLINE; CHICK EMBRYO; CLOSTRIDIUM BOTULINUM; EXPERIMENTAL LAB STUDY; JOINT DISEASES; MUSCLES; MUSCULAR ATROPHY; NEUROMUSCULAR JUNCTION; PATHOLOGY; TOXICOLOGIC REPORT; TOXINS AND ANTITOXINS