REVERSIBLE COLD BLOCK OF THE SPECIALIZED CARDIAC TISSUES OF THE UNANAESTHETIZED DOG.
The sinoatrial node and the bundle of His in intact, unanesthetized dogs were subjected to local cooling by means of surgically implanted devices. Impulse formation in the sinoatrial node could thus be suppressed at will and the heart rate regulated within a physiological range by an electrode driving the atrium. Reversible blockage of atrioventricular conduction was easily induced on cooling the region of the bundle of His.
D002036:Bundle of His; D004285:Dogs; D004562:Electrocardiography; D004566:Electrodes; D006321:Heart; D006329:Heart Conduction System; D006339:Heart Rate; D007035:Hypothermia; D007036:Hypothermia, Induced; D010827:Physiology; D012106:Research; D012849:Sinoatrial Node
DOGS; ELECTROCARDIOGRAPHY; EXPERIMENTAL LAB STUDY; HEART CONDUCTION SYSTEM; HYPOTHERMIA, INDUCED; PHYSIOLOGY