ACTINOMYCIN D: AN EFFECT ON RAT LIVER HOMOGENATES UNRELATED TO ITS ACTION ON RNA SYNTHESIS.
Liver homogenates prepared from rats injected with high doses of actinomycin D show a decrease in polyribosome content and in amino acid incorporation. These effects are not observed in rat liver not subjected to homogenization and are independent of the inhibition of RNA synthesis caused by the antibiotic.
D000596:Amino Acids / Q000378:metabolism*; D003609:Dactinomycin; D008099:Liver / Q000166:cytology*; D008660:Metabolism; D008861:Microsomes; D010336:Pathology; D010600:Pharmacology; D012313:RNA; D051381:Rats; D012106:Research; D012270:Ribosomes
D000596:Amino Acids; D003609:Dactinomycin; D012313:RNA
ACTINOMYCIN; AMINO ACID METABOLISM; EXPERIMENTAL LAB STUDY; HOMOGENATES; LIVER CYTOLOGY; METABOLISM; MICROSOMES; PATHOLOGY; PHARMACOLOGY; RATS; RIBOSOMES; RNA