EVOLUTION OF A CATABOLIC PATHWAY IN BACTERIA.
Genetic derepression of ribitol dehydrogenase in a mutant of Aerobacter aerogenes, strain 1033, enabled it to grow on xylitol, a substrate of the enzyme, but not its inducer. A derivative strain with an improved rate of growth on xylitol was obtained from the first mutant. The faster growth rate was made possible by the production of an altered ribitol dehydrogenase, as demonstrated by an increase in its activity on xylitol relative to ribitol and by its decreased heat stability.
D000429:Alcohol Oxidoreductases; D000438:Alcohols; D001419:Bacteria; D005075:Biological Evolution; D021902:Enterobacter aerogenes; D005823:Genetics; D008660:Metabolism; D009154:Mutation; D010770:Phosphotransferases; D012106:Research; D014993:Xylitol
D000438:Alcohols; D000429:Alcohol Oxidoreductases; D010770:Phosphotransferases; D014993:Xylitol
AEROBACTER AEROGENES; ALCOHOL OXIDOREDUCTASES; ALCOHOLS; EXPERIMENTAL LAB STUDY; GENETICS; METABOLISM; XYLITOL