title: IMMUNIZATION AGAINST BRUCELLA INFECTION. 10. THE RELATIVE IMMUNOGENICITY OF BRUCELLA ABORTUS STRAIN 19-BA  AND BRUCELLA MELITENSIS STRAIN REV I IN CYNOMOLGUS PHILIPPINENSIS.
abstract: Continuing previous studies, the authors investigated the immunogenicity of low doses of Brucella melitensis strain Rev I in Cynomolgus monkeys challenged by the respiratory route and compared the efficacy of Rev I vaccine with that of vaccine from Br. abortus strain 19-BA.Challenge with the virulent Br. melitensis strain 6015 indicated that 19-BA vaccine was considerably more effective when administered intracutaneously than subcutaneously, whereas with Rev I vaccine the difference was slight, but Rev I conferred immunity in much lower doses. It was found that a dose as low as 260 cells of Rev I led to a high degree of immunity, although there was a very pronounced delay in the bacteriological response. The authors conclude that the results obtained justify trials of the safety of Rev I vaccine for man in the low dosage effective for cynomolgi.
mesh_terms: D000818:Animals; D001769:Blood; D001831:Body Temperature; D002002:Brucella; D002004:Brucella Vaccine; D002003:Brucella abortus; D017347:Brucella melitensis; D002006:Brucellosis; D000882:Haplorhini; D006384:Hemagglutination; D012106:Research; D014611:Vaccination
chemical_list: D002004:Brucella Vaccine
keywords: BLOOD; BODY TEMPERATURE; BRUCELLA; BRUCELLA ABORTUS; BRUCELLA VACCINE; BRUCELLOSIS; EXPERIMENTAL LAB STUDY; HEMAGGLUTINATION; MONKEYS; VACCINATION