THE REPOLARIZATION PHASE OF THE CARDIAC VENTRICULAR ACTION POTENTIAL: A TIME-DEPENDENT SYSTEM OF MEMBRANE CONDUCTANCES.
A system for the generation of the repolarization phase of the ventricular action potential is described. The system is based on time-dependent changes in membrane conductance to sodium and potassium ions. However, the changes in conductance during an action potential retain a degree of voltage dependence through the initial conditions which depend on previous depolarizations of the membrane. The equations describing the system were solved with an analog computer and various action potential forms are reproduced. The effects of hyperpolarizing and depolarizing current applied during an action potential are investigated. The changes in shape of an action potential after a change in the rate of stimulation show partial agreement with previous experimental findings. The applicability of time-dependent and voltage-dependent systems for the generation of the repolarization phase of the ventricular action potential is discussed.
D000200:Action Potentials; D004594:Electrophysiology; D006321:Heart; D006352:Heart Ventricles; D007474:Ion Exchange; D007477:Ions; D018408:Patch-Clamp Techniques; D010827:Physiology; D011188:Potassium; D012964:Sodium
D007477:Ions; D012964:Sodium; D011188:Potassium
ELECTROPHYSIOLOGY; HEART; ION EXCHANGE; IONS; PHYSIOLOGY; POTASSIUM; SODIUM