THALIDOMIDE SYNDROME IN MONKEYS.
Pregnant monkeys were treated with thalidomide after implantation but before formation of the fetal limbs. Two fetuses that were recovered from the treated females had congenital abnormalities. The thalidomide syndrome in the monkeys was manifested by amelia, phocomelia, internal hydrocephaly, facial capillary hemangioma, hypogenesis of the metatarsal bones, and anotia.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D010064:Embryo Implantation; D005121:Extremities; D005260:Female; D005333:Fetus; D000882:Haplorhini; D006801:Humans; D008682:Metatarsal Bones; D011247:Pregnancy; D011270:Pregnancy, Animal; D012106:Research; D013577:Syndrome; D013792:Thalidomide; D014116:Toxicology
D013792:Thalidomide
ABNORMALITIES, DRUG-INDUCED; EXPERIMENTAL LAB STUDY; MONKEYS; PREGNANCY; PREGNANCY, ANIMAL; THALIDOMIDE; TOXICOLOGIC REPORT