title: STUDIES ON THE MECHANISM OF DESTRUCTION OF THE TOXIC ACTION OF WHEAT GLUTEN IN COELIAC DISEASE BY CRUDE PAPAIN.
abstract: The toxic action of wheat gluten on two patients was eliminated after predigestion of gluten by crude papain. This change is thought to be due to an enzyme which liberates ammonia from gluten. It is not thought that this particular mechanism operates in the normal intestinal cell but it is envisaged that one of the peptide bonds of the coeliac active constituent (possibly a N-glutaminyl peptide) is normally split by a specific intestinal peptidase which is defective in coeliac patients.
mesh_terms: D000596:Amino Acids; D000641:Ammonia; D001835:Body Weight; D002446:Celiac Disease; D002648:Child; D004063:Digestion; D005243:Feces; D005983:Glutens; D006801:Humans; D007223:Infant; D010206:Papain; D010447:Peptide Hydrolases; D010455:Peptides; D011760:Pyrrolidinones; D014116:Toxicology; D014908:Triticum
chemical_list: D000596:Amino Acids; D010455:Peptides; D011760:Pyrrolidinones; D000641:Ammonia; D005983:Glutens; D010447:Peptide Hydrolases; D010206:Papain
keywords: AMINO ACIDS; AMMONIA; BODY WEIGHT; CELIAC DISEASE; CHILD; DIGESTION; FECES; GLUTEN; INFANT; PAPAIN; PEPTIDE HYDROLASES; PEPTIDES; PYRROLIDINONES; TOXICOLOGIC REPORT; WHEAT