HEMOGLOBINS A AND F: FORMATION IN THALASSEMIA AND OTHER HEMOLYTIC ANEMIAS.
Rates of synthesis of hemoglobin A by erythroid cells from thalassemic subjects are markedly decreased. Formation of hemoglobin F, however, proceeds at similar rates in cells from subjects with thalassemia and other types of hemolytic anemias. A mechanism is suggested regarding the altered patterns of hemoglobin synthesis under conditions of erythropoietic stimulation in subjects with and without thalassemia.
D000743:Anemia, Hemolytic; D002247:Carbon Isotopes; D004247:DNA; D004920:Erythropoiesis; D005319:Fetal Hemoglobin; D006441:Hemoglobin A; D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; D006651:Histocytochemistry; D006801:Humans; D007532:Isoleucine; D007930:Leucine; D011506:Proteins / Q000378:metabolism*; D012313:RNA; D012156:Reticulocytes; D012270:Ribosomes; D013789:Thalassemia
D002247:Carbon Isotopes; D006454:Hemoglobins; D006455:Hemoglobins, Abnormal; D011506:Proteins; D007532:Isoleucine; D012313:RNA; D004247:DNA; D006441:Hemoglobin A; D005319:Fetal Hemoglobin; D007930:Leucine
CARBON ISOTOPES; DNA; ERYTHROPOIESIS; HEMOGLOBINS, ABNORMAL; HISTOCYTOCHEMISTRY; ISOLEUCINE; LEUCINE; PROTEIN METABOLISM; RIBOSOMES; RNA; THALASSEMIA