EFFECTS OF AMPHETAMINE ON THE RESPONSES OF THE GUINEA-PIG ISOLATED VAS DEFERENS PREPARATION TO HYPOGASTRIC NERVE STIMULATION.
In concentrations from 1 to 100 mug/ml., amphetamine potentiated responses of the isolated vas deferens preparation of the guinea-pig stimulated via the hypogastric nerve at rates of from 5 to 40 shocks/sec. Potentiation was more pronounced with low than with high stimulus frequencies. A concentration of 500 mug/ml. of amphetamine had a blocking action which was more pronounced at high than at low stimulus frequencies. This effect contrasted with the ganglionic blocking action of hexamethonium which had a greater effect at low than at high stimulus frequencies.
D000661:Amphetamine; D000818:Animals; D017776:Autonomic Pathways; D004558:Electric Stimulation; D004809:Ephedrine; D005730:Ganglionic Blockers; D006168:Guinea Pigs; D006584:Hexamethonium Compounds; D006801:Humans; D008297:Male; D009469:Neuromuscular Junction; D009638:Norepinephrine; D010600:Pharmacology; D012106:Research; D013564:Sympathetic Nervous System; D014439:Tyramine; D014649:Vas Deferens
D005730:Ganglionic Blockers; D006584:Hexamethonium Compounds; D000661:Amphetamine; D004809:Ephedrine; D009638:Norepinephrine; D014439:Tyramine
AMPHETAMINE; ELECTRIC STIMULATION; EPHEDRINE; EXPERIMENTAL LAB STUDY; GUINEA PIGS; HEXAMETHONIUM COMPOUNDS; NEUROMUSCULAR JUNCTION; NOREPINEPHRINE; PHARMACOLOGY; SYMPATHETIC NERVOUS SYSTEM; TYRAMINE; VAS DEFERENS