title: RESPONSE OF VOLTA CHILDREN TO LIVE ATTENUATED MEASLES VIRUS VACCINE.
abstract: Experience so far with the Enders B-level Edmonston strain of live attenuated measles vaccine has been principally with children in the USA in whom natural measles carries a low mortality. Measles is associated with an appreciably higher mortality rate in developing countries; in Upper Volta, climate, nutritional status, degree of parasitic infestation and concurrent infections may contribute to this. The present report summarizes a pilot study in Ouagadougou, Upper Volta, designed to obtain information on the response of Volta children to Enders vaccine and to determine the feasibility of using this vaccine on a large scale.The observations indicate that Volta children, despite the hazards of natural measles, respond in essentially the same manner to live vaccine given alone or with gamma-globulin as do children in other areas. The febrile reactions which characterize infection with the attenuated measles virus were of insufficient importance to warrant the concurrent use of gamma-globulin in a forthcoming mass measles vaccination campaign in Upper Volta.
mesh_terms: D000349:Africa; D000350:Africa, Central; D000740:Anemia; D002050:Burkina Faso; D002648:Child; D003141:Communicable Diseases; D006801:Humans; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D008288:Malaria; D032541:Mass Vaccination; D008457:Measles; D008458:Measles Vaccine; D008459:Measles virus; D010865:Pilot Projects; D013223:Statistics as Topic; D014611:Vaccination; D014612:Vaccines; D005719:gamma-Globulins
chemical_list: D008458:Measles Vaccine; D014612:Vaccines; D005719:gamma-Globulins
keywords: AFRICA, CENTRAL; ANEMIA; CHILD; GAMMA GLOBULIN; INFANT; INFANT NUTRITION; MALARIA; MEASLES; MEASLES VACCINE; STATISTICS; VACCINATION