title: GENETIC REGULATORY MECHANISMS AT THE POPULATION LEVEL IN MAN.
abstract: The distribution of the Rhesus and ABO blood groups, thalassemia, and glucose-6-phosphate dehydrogenase deficiency in Europe and in Jewish populations argues for a regulatory mechanism at the population level which adjusts gene frequencies so that the overall genetic load is not excessive, since gene frequencies giving a high genetic load at one locus are often associated with those giving low genetic loads at other loci.
mesh_terms: D000017:ABO Blood-Group System; D005006:Ethnicity; D005060:Europe; D005787:Gene Frequency; D005826:Genetics, Medical; D005828:Genetics, Population; D005955:Glucosephosphate Dehydrogenase Deficiency; D005958:Glucosephosphates; D006801:Humans; D008297:Male; D011153:Population; D012204:Rh-Hr Blood-Group System; D013789:Thalassemia
chemical_list: D000017:ABO Blood-Group System; D005958:Glucosephosphates; D012204:Rh-Hr Blood-Group System
keywords: ABO FACTORS; GENETICS, HUMAN; GENETICS, POPULATION; GLUCOSEPHOSPHATE DEHY- DROGENASE DEFICIENCY; POPULATION; RH FACTORS; THALASSEMIA