IMMUNOLOGICAL AND BIOCHEMICAL STUDIES ON SERUM HAPTOGLOBIN.
Antibody to purified type 1-1 human serum haptoglobin was obtained in rabbits. Using this antiserum it was demonstrated that the antigenic determinants of the haptoglobin molecule reside in both alpha- and beta-chains. No immunological difference between the normal alpha(1F)- and alpha(1S)-chains of haptoglobin could be detected. A number of healthy individuals whose haptoglobin pattern appeared normal by starch gel electrophoresis were shown to possess a haptoglobin which could be distinguished immunologically from the common haptoglobin types. These immunological atypical haptoglobins have been observed in individuals of types 1-1, 2-1, and 2-2. Combined immunological and chemical studies of purified haptoglobin have enabled the construction of a tentative model for the structure of human type 1-1 haptoglobin.
D000818:Animals; D001797:Blood Protein Electrophoresis; D055598:Chemical Phenomena; D002621:Chemistry; D000882:Haplorhini; D006242:Haptoglobins; D015186:Hominidae; D006801:Humans; D007106:Immune Sera; D007122:Immunoelectrophoresis; D010455:Peptides; D011817:Rabbits; D012106:Research
D006242:Haptoglobins; D007106:Immune Sera; D010455:Peptides
APES; BLOOD PROTEIN ELECTROPHORESIS; CHEMISTRY; EXPERIMENTAL LAB STUDY; HAPTOGLOBINS; IMMUNOELECTROPHORESIS; MONKEYS; PEPTIDES; RABBITS