PROTEIN SYNTHESIS ENHANCED IN THE LIVER OF RATS FORCE-FED A THREONINE-DEVOID DIET.
There is enhanced incorporation of leucine-C(14) into proteins in cell-free preparations from livers of young rats force-fed a threonine-devoid diet for 3 days. This increased protein synthesis in the liver is related predominantly to enhanced activity of ribosomes. The aggregates of liver ribosomes (ergosonmes or polysomes) as measured in a sucrose gradient indicated a shift from lighter toward heavier ergosomes with a decrease in monomers.
D000596:Amino Acids / Q000378:metabolism*; D002247:Carbon Isotopes; D003677:Deficiency Diseases; D004032:Diet; D007930:Leucine; D008099:Liver / Q000502:physiology*; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism*; D012106:Research; D012270:Ribosomes; D013912:Threonine
D000596:Amino Acids; D002247:Carbon Isotopes; D011506:Proteins; D013912:Threonine; D007930:Leucine
AMINO ACID METABOLISM; CARBON ISOTOPES; DEFICIENCY DISEASES; EXPERIMENTAL LAB STUDY; LEUCINE; LIVER FUNCTION; PROTEIN METABOLISM; RIBOSOMES; THREONINE