CYCLOHEXIMIDE: ASPECTS OF INHIBITION OF PROTEIN SYNTHESIS IN MAMMALIAN CELLS.
Cycloheximide and acetoxy-cycloheximide specifically inhibit protein synthesis in L-cells growing in suspension culture. In extracts of rat liver, the drugs inhibit transfer of amino acid from soluble RNA to polypeptide. Unlike puromycin, these drugs do not accelerate release of nascent polypeptide chains. The drugs have no effect on protein synthesis in extracts of Escherichia coli.
D000596:Amino Acids / Q000378:metabolism*; D000900:Anti-Bacterial Agents; D000963:Antimetabolites; D003513:Cycloheximide; D004926:Escherichia coli; D007739:L Cells; D008110:Liver Extracts; D010455:Peptides; D010600:Pharmacology; D011506:Proteins / Q000378:metabolism*; D011691:Puromycin; D012313:RNA; D012106:Research
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000963:Antimetabolites; D008110:Liver Extracts; D010455:Peptides; D011506:Proteins; D011691:Puromycin; D012313:RNA; D003513:Cycloheximide
AMINO ACID METABOLISM; ANTIBIOTICS; ANTIMETABOLITES; EXPERIMENTAL LAB STUDY; L CELLS; LIVER EXTRACTS; PHARMACOLOGY; PROTEIN METABOLISM; RNA, SOLUBLE