title: THE CHEMOTHERAPY OF CARDIAC ARREST.
abstract: Direct-air ventilation, external cardiac compression, and external defibrillation are established techniques for patients who unexpectedly develop cardiac arrest. The proper use of drugs can increase the incidence of successful resuscitation. Intracardiac adrenaline (epinephrine) acts as a powerful stimulant during cardiac standstill and, in addition, converts fine ventricular fibrillation to a coarser type, more responsive to electrical defibrillation. Routine use of intravenous sodium bicarbonate is recommended to combat the severe metabolic acidosis accompanying cardiac arrest. Lidocaine is particularly useful when ventricular fibrillation or ventricular tachycardia tends to recur. Analeptics are contraindicated, since they invariably increase oxygen requirements of already hypoxic cerebral tissues. The following acrostic is a useful mnemonic for recalling the details of the management of cardiac arrest in their proper order: A (Airway), B (Breathing), C (Circulation), D (Diagnosis of underlying cause), E (Epinephrine), F (Fibrillation), G (Glucose intravenously), pH (Sodium bicarbonate), I (Intensive care).
mesh_terms: D000138:Acidosis; D001145:Arrhythmias, Cardiac; D001639:Bicarbonates; D053840:Brugada Syndrome; D000075224:Cardiac Conduction System Disease; D003422:Critical Care; D004358:Drug Therapy; D004554:Electric Countershock; D004837:Epinephrine; D005947:Glucose; D006323:Heart Arrest; D006329:Heart Conduction System; D006801:Humans; D007362:Intensive Care Units; D008012:Lidocaine; D012151:Resuscitation; D017693:Sodium Bicarbonate; D017180:Tachycardia, Ventricular; D014693:Ventricular Fibrillation
chemical_list: D001639:Bicarbonates; D017693:Sodium Bicarbonate; D008012:Lidocaine; D005947:Glucose; D004837:Epinephrine
keywords: ACIDOSIS; BICARBONATES; DRUG THERAPY; EPINEPHRINE; GLUCOSE; HEART ARREST; INTENSIVE CARE UNITS; LIDOCAINE; VENTRICULAR FIBRILLATION