THE EFFECTS OF ANTIMONY UPTAKE ON THE LOCATION AND PAIRING OF SCHISTOSOMA MANSONI.
The rate of uptake and elimination of antimony by both male and female schistosomes has been measured. It has been confirmed that the female schistosome is more susceptible to antimony therapy than the male since she absorbs more drug. The changes in location of the worms and the separation of the sexes following one or more injections of antimony potassium tartrate have been related to the different rates of uptake and elimination of the drug by the two sexes. The suppressive treatment of schistosomiasis is discussed in the light of these observations.
D000818:Animals; D000871:Anthelmintics; D000965:Antimony; D000966:Antimony Potassium Tartrate; D005260:Female; D008297:Male; D008660:Metabolism; D051379:Mice; D010600:Pharmacology; D012106:Research; D012547:Schistosoma; D012550:Schistosoma mansoni; D012552:Schistosomiasis
D000871:Anthelmintics; D000965:Antimony; D000966:Antimony Potassium Tartrate
ANTHELMINTICS; ANTIMONY; EXPERIMENTAL LAB STUDY; METABOLISM; MICE; PHARMACOLOGY; SCHISTOSOMA; SCHISTOSOMIASIS