INDUCTION OF SEVERAL ADAPTIVE ENZYMES BY ACTINOMYCIN D.
Although actinomycin D has been used to prevent protein synthesis in experiments of several hours' duration, its effects on the synthesis of adaptive enzymes which are induced over a period of several days have received less attention. Treatment of young rats with doses of actinomycin D, which permitted survival for a period of 5 days, resulted in marked increases in the activities of four hepatic enzymes known to be induced by cortisol: alanine transaminase, tyrosine transaminase, serine dehydrase, and tryptophan pyrrolase. Actinomycin D also induced responses of two of these enzymes in adrenalectomized rats.
D000315:Adrenalectomy; D000410:Alanine Transaminase; D003609:Dactinomycin; D006836:Hydro-Lyases; D006854:Hydrocortisone; D008099:Liver / Q000201:enzymology*; D008660:Metabolism; D010600:Pharmacology; D051381:Rats; D012106:Research; D012694:Serine; D000637:Transaminases
D003609:Dactinomycin; D012694:Serine; D000637:Transaminases; D000410:Alanine Transaminase; D006836:Hydro-Lyases; D006854:Hydrocortisone
ACTINOMYCIN; ADRENALECTOMY; ALANINE AMINOTRANSFERASE; AMINOTRANSFERASES; EXPERIMENTAL LAB STUDY; HYDRO-LYASES; HYDROCORTISONE; LIVER ENZYMOLOGY; METABOLISM; PHARMACOLOGY; RATS