title: CADAVER RENAL HOMOTRANSPLANTS: INITIAL EXPERIENCES.
abstract: Four renal homotransplants were carried out between cadaver donors and four recipients, all of whom were in terminal chronic renal failure. Immune suppression was attempted with azathioprine (Imuran), actinomycin C and prednisone; no radiation was used, nor were the recipient's kidneys, spleen or thymus removed. One patient died with disseminated histoplasmosis at two weeks; another with irreversible homograft rejection at 30 days; a third patient died of septicemia after 9(1/2) weeks with stable renal function. The fourth patient, whose transplant had been ischemic for 190 minutes and had not functioned for 2(1/2) weeks thereafter, eventually achieved good function which remained unchanged to 7(1/2) months. Changes in urinary enzyme excretion and in the I(131) renogram and meralluride scan were of value in assessing homograft rejection.
mesh_terms: D001379:Azathioprine; D002102:Cadaver; D003609:Dactinomycin / Q000031:analogs & derivatives; D004798:Enzymes; D006660:Histoplasmosis; D006801:Humans; D007093:Imidazoles; D007166:Immunosuppressive Agents; D007456:Iodine Isotopes; D007668:Kidney; D007676:Kidney Failure, Chronic; D016030:Kidney Transplantation; D010336:Pathology; D011241:Prednisone; D011868:Radioisotopes; D011877:Radionuclide Imaging; D018805:Sepsis; D013154:Spleen; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
chemical_list: D004798:Enzymes; D007093:Imidazoles; D007166:Immunosuppressive Agents; D007456:Iodine Isotopes; D011868:Radioisotopes; C030013:cactinomycin; D003609:Dactinomycin; D001379:Azathioprine; D011241:Prednisone
keywords: ACTINOMYCIN; AZATHIOPRINE; CADAVER; ENZYMES; HISTOPLASMOSIS; IMIDAZOLES; IMMUNOSUPPRESSIVE AGENTS; IODINE ISOTOPES; KIDNEY TRANSPLANTATION; PATHOLOGY; PREDNISONE; RADIOISOTOPE SCANNING; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION, HOMOLOGOUS