title: SEROLOGICAL ANALYSES OF CELLULAR SLIME-MOLD DEVELOPMENT. I. CHANGES IN ANTIGENIC ACTIVITY DURING CELL AGGREATION.
abstract: Sonneborn, D. R. (Brandeis University, Waltham, Mass.), M. Sussman, and L. Levine. Serological analysis of cellular slime-mold development. I. Changes in antigenic activity during cell aggregation. J. Bacteriol. 87:1321-1329. 1964.-During aggregation in Dictyostelium discoideum, the concentration of a single antigenic determinant increased markedly, starting from very low or undetectable levels. Subsequently, the determinant appeared to segregate preferentially into the stalks of terminal fruiting bodies. Sera containing the antibody specific for this determinant inhibited the aggregation of D. discoideum without disturbing cell viability. The properties of the antigen during fractionation are consistent with the supposition that it may be a protein associated with the cell membrane. The ability or inability of three species to coaggregate with D. discoideum was correlated with the presence or absence of the antigenic determinant in aggregates of these species.
mesh_terms: D000941:Antigens; D002462:Cell Membrane; D016837:Dictyosteliida; D000939:Epitopes; D005658:Fungi; D007106:Immune Sera; D010600:Pharmacology; D011506:Proteins; D012106:Research
chemical_list: D000941:Antigens; D000939:Epitopes; D007106:Immune Sera; D011506:Proteins
keywords: ANTIGENS; CELL MEMBRANE; EXPERIMENTAL LAB STUDY; FUNGI; IMMUNE SERUMS; PHARMACOLOGY