title: LINCOMYCIN: A NEW ANTIBIOTIC ACTIVE AGAINST STAPHYLOCOCCI AND OTHER GRAM-POSITIVE COCCI: CLINICAL AND LABORATORY STUDIES.
abstract: Preliminary results suggest that the antibiotic lincomycin (a product of Streptomyces lincolnensis var. lincolnensis) possesses certain valuable properties which include good in vitro activity against many strains of hospital staphylococci resistant to many other antibiotics. During a study of this agent, a selected series of severe staphylococcal infections due to resistant organisms were treated with lincomycin, with encouraging responses. Favourable results were also noted in seven cases of osteomyelitis. Lincomycin may be administered by the oral or parenteral routes to adults and infants and satisfactory serum blood levels obtained. So far as the authors' limited experience enables them to conclude, and at the dose range tested, this antibiotic promises to be one of low toxicity.
mesh_terms: D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D001432:Bacteriology; D035843:Biomedical Research; D002170:Canada; D002701:Chloramphenicol; D004351:Drug Resistance; D004352:Drug Resistance, Microbial; D004358:Drug Therapy; D004917:Erythromycin; D005853:Geriatrics; D006095:Gram-Positive Cocci; D006801:Humans; D007223:Infant; D008034:Lincomycin; D008712:Methicillin; D009675:Novobiocin; D010019:Osteomyelitis; D010406:Penicillins; D012106:Research; D013203:Staphylococcal Infections; D013210:Staphylococcus; D013307:Streptomycin; D013752:Tetracycline; D014116:Toxicology
chemical_list: D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D010406:Penicillins; D009675:Novobiocin; D004917:Erythromycin; D002701:Chloramphenicol; D008034:Lincomycin; D013752:Tetracycline; D008712:Methicillin; D013307:Streptomycin
keywords: ANTIBIOTICS; BACTERIOLOGY; CANADA; CHLORAMPHENICOL; CLINICAL RESEARCH; DRUG RESISTANCE, MICROBIAL; DRUG THERAPY; ERYTHROMYCIN; EXPERIMENTAL LAB STUDY; GERIATRICS; INFANT; LINCOMYCIN; METHICILLIN; NOVOBIOCIN; OSTEOMYELITIS; PENICILLIN; STAPHYLOCOCCAL INFECTIONS; STREPTOMYCIN; TETRACYCLINE; TOXICOLOGIC REPORT