title: SOME BIOCHEMICAL CHANGES IN THE GUINEA PIG DURING INFECTION WITH COXIELLA BURNETII.
abstract: Paretsky, D. (University of Kansas, Lawrence), C. M. Downs, and C. W. Salmon. Some biochemical changes in the guinea pig during infection with Coxiella burnetii. J. Bacteriol. 88:137-142. 1964.-Guinea pigs infected with Coxiella burnetii, the rickettsial agent of Q fever, were studied for 11 days postinfection. Maximal changes in liver lipids, liver phosphorylase, and uridine diphosphate glucose (UDPG)-glycogen glucosyl-transferase activities occurred 3 to 4 days post-infection. In this period, total liver lipids increased from 1.26 to 5.46 mg/mg of N, with the largest increment in the glyceride fraction. Liver glycogen virtually disappeared by the second day, with no chemically detectable restoration until the eleventh day. A pattern of altered phosphorylase and UDPG-glycogen transglucosylase activities was observed, with maximal phosphorylase and minimal glucosyltransferase activities at the third and fourth days. Histochemical observations confirmed chemical analyses for lipids and glycogen.
mesh_terms: D000818:Animals; D050260:Carbohydrate Metabolism; D002784:Cholesterol; D016997:Coxiella burnetii; D005964:Glucosyltransferases; D005989:Glycerides; D006003:Glycogen; D006168:Guinea Pigs; D008025:Ligases; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology*; D008112:Liver Glycogen; D010743:Phospholipids; D010770:Phosphotransferases; D011778:Q Fever; D012106:Research
chemical_list: D005989:Glycerides; D008112:Liver Glycogen; D010743:Phospholipids; D006003:Glycogen; D002784:Cholesterol; D005964:Glucosyltransferases; D010770:Phosphotransferases; D008025:Ligases
keywords: CARBOHYDRATE METABOLISM; CHOLESTEROL; EXPERIMENTAL LAB STUDY; GLUCOSYLTRANSFERASES; GLYCERIDES; GLYCOGEN; GUINEA PIGS; LIGASES; LIPID METABOLISM; LIVER; LIVER ENZYMOLOGY; LIVER GLYCOGEN; PHOSPHOLIPIDS; PHOSPHOTRANSFERASES; Q FEVER