A CONTROLLED TRIAL OF LIVER-VIRUS VACCINE AGAINST MEASLES IN CHILE.
In view of the high mortality from measles in Chile, it was decided to undertake a double-blind, controlled trial of the Enders Edmonston B strain of live measles vaccine in that country as part of a WHO-sponsored programme to obtain information on reactions to that vaccine strain and on the antibody response elicited in children.Between July and December 1962, some 530 children 8 months to 3 years old received inoculations of vaccine, with or without gamma-globulin, or were given a placebo injection. The reactions were generally of moderate intensity and were not appreciably reduced in either frequency or intensity by gamma-globulin. Serological conversion was achieved in about 90% of the vaccinated.On the basis of this experience, it was decided to institute a large-scale immunization in Chile with the same vaccine; the campaign began in May 1963.
D002648:Child; D002677:Chile; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D007390:International Agencies; D008099:Liver; D008457:Measles; D008458:Measles Vaccine; D013223:Statistics as Topic; D014611:Vaccination; D005719:gamma-Globulins
D008458:Measles Vaccine; D005719:gamma-Globulins
CHILD; CHILE; GAMMA GLOBULIN; INFANT; INTERNATIONAL AGENCIES; MEASLES; MEASLES VACCINE; STATISTICS; VACCINATION