TRANSPLANTATION OF RAT BONE MARROW IN IRRADIATED MICE: EFFECT OF EXPOSURE RATE.
Mice were irradiated at several different exposure rates so that they received a total of 900 roentgens over the whole body. Within 2 hours they were injected with rat bone marrow. The success of the transplantation depended upon the rate at which the animals had been irradiated: the higher the rate, the greater the success of the grafts. Failure of grafts in mice subjected to low exposure-rates was associated with antibody formation. The data indicate existence of an immune mechanism which is dependent on the radiation exposure-rate.
D000818:Animals; D000906:Antibodies; D000917:Antibody Formation; D001853:Bone Marrow; D016026:Bone Marrow Transplantation; D004912:Erythrocytes; D051379:Mice; D011830:Radiation Effects; D051381:Rats; D012106:Research; D013154:Spleen; D014181:Transplantation Immunology; D014183:Transplantation, Heterologous
D000906:Antibodies
ANTIBODIES; BONE MARROW TRANSPLANTATION; ERYTHROCYTES; EXPERIMENTAL LAB STUDY; MICE; RADIATION EFFECTS; RATS; SPLEEN; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION, HETEROLOGOUS