title: THE IMMUNOGLOBULINS OF MICE. II. TWO SUBCLASSES OF MOUSE 7S  GAMMA-2-GLOBULINS: GAMMA-2A- AND GAMMA-2B-GLOBULINS.
abstract: Two subclasses of mouse 7S gamma(2)-globulins are identified, and are designated gamma(2a)- and gamma(2b)-globulins. They are distinguished from 7S gamma(1)-globulins, gamma(1A) (beta(2A))-globulins, and gamma(1M)-globulins of mouse serum. Antibody activity was detected among the gamma(2a)-globulins and gamma(2b)-globulins of hyperimmune mouse serum. gamma(2a)- and gamma(2b)-myeloma proteins were identified. The genetically determined isoantigen, Iga-1, was present on gamma(2a)-myeloma proteins, but not on gamma(2b)-myeloma proteins. These findings indicate a complexity among the 7S gamma(2)-globulins which must be taken into account in structural, functional, and genetic studies of immunoglobulins.
mesh_terms: D000818:Animals; D000937:Antigen-Antibody Reactions; D000941:Antigens; D007122:Immunoelectrophoresis; D007074:Immunoglobulin G; D051379:Mice; D009101:Multiple Myeloma; D009363:Neoplasm Proteins; D011233:Precipitin Tests; D012106:Research; D014461:Ultracentrifugation; D005719:gamma-Globulins
chemical_list: D000941:Antigens; D007074:Immunoglobulin G; D009363:Neoplasm Proteins; D005719:gamma-Globulins
keywords: ANTIGEN-ANTIBODY REACTIONS; ANTIGENS; EXPERIMENTAL LAB STUDY; GAMMA GLOBULIN; GAMMA GLOBULIN, 7S; IMMUNOELECTROPHORESIS; MICE; MULTIPLE MYELOMA; NEOPLASM PROTEINS; PRECIPITIN TESTS; ULTRACENTRIFUGATION