title: PROTON TUNNELING IN RADIATION-INDUCED MUTATION.
abstract: The equilibrium proton distribution and tunneling rate in the N-H. . . N hydrogen bond of the guanine-cytosine base pair have been calculated quantum mechanically for the ground state, a charge-transfer excited state, and positive and negative ionic states. These results are consistent with the idea that tautomeric rearrangement can be a cause of radiation induced mutation or carcinogenesis.
mesh_terms: D020029:Base Pairing; D003596:Cytosine; D004247:DNA; D005815:Genetic Code; D006147:Guanine; D006860:Hydrogen Bonding; D009154:Mutation; D009705:Nucleosides; D011522:Protons; D011831:Radiation Genetics; D012106:Research
chemical_list: D009705:Nucleosides; D011522:Protons; D006147:Guanine; D003596:Cytosine; D004247:DNA
keywords: CYTOSINE; DNA; EXPERIMENTAL LAB STUDY; GENETIC CODE; MUTATION; NUCLEOSIDES; RADIATION GENETICS