AMINO ACIDS: INCORPORATION INTO ALPHA- AND BETA-CHAINS OF HEMOGLOBIN BY NORMAL AND THALASSEMIC RETICULOCYTES.
After incubation of reticulocytes with radioactive amino acid, the specific activity of the beta-chain of globin from the blood of patients with thalassemia was consistently lower than that of the alpha-chain. In subjects without this disorder, the specific activity of the beta-chain was always equal to or higher than that of the alpha-chain.
D000596:Amino Acids; D000755:Anemia, Sickle Cell; D002247:Carbon Isotopes; D005914:Globins; D006454:Hemoglobins; D006801:Humans; D007930:Leucine; D007938:Leukemia; D011506:Proteins / Q000378:metabolism*; D012106:Research; D012156:Reticulocytes; D013789:Thalassemia; D014633:Valine
D000596:Amino Acids; D002247:Carbon Isotopes; D006454:Hemoglobins; D011506:Proteins; D005914:Globins; D007930:Leucine; D014633:Valine
ANEMIA, SICKLE CELL; CARBON ISOTOPES; EXPERIMENTAL LAB STUDY; HEMOGLOBIN; LEUCINE; LEUKEMIA; PROTEIN METABOLISM; RETICULOCYTES; THALASSEMIA; VALINE