ON THE USE OF TRITIUM-LABELLED ALBUMIN FOR STUDIES OF INTESTINAL ABSORPTION.
Human serum albumin has been successfully labelled with tritium. It is considerably denatured in the process and has a shorter half life when given intravenously than (131)I-labelled albumin. Nevertheless it is satisfactory for absorption studies, although not for turnover observations. These studies on absorption in control subjects and in patients with intestinal malabsorption indicate that the excreted radioactivity may have been derived from endogenous sources rather than from the results of malabsorption alone.
D035843:Biomedical Research; D001797:Blood Protein Electrophoresis; D002446:Celiac Disease; D002845:Chromatography; D003424:Crohn Disease; D004147:Dioxins; D004739:England; D004751:Enteritis; D005243:Feces; D006801:Humans; D007408:Intestinal Absorption; D007421:Intestine, Small; D007422:Intestines; D008286:Malabsorption Syndromes; D009584:Nitrogen; D010195:Pancreatitis; D011178:Postgastrectomy Syndromes; D012709:Serum Albumin; D012965:Sodium Chloride; D013223:Statistics as Topic; D013514:Surgical Procedures, Operative; D014316:Tritium
D004147:Dioxins; D012709:Serum Albumin; D014316:Tritium; D012965:Sodium Chloride; D009584:Nitrogen
BLOOD PROTEIN ELECTROPHORESIS; CHROMATOGRAPHY; CLINICAL RESEARCH; DIOXINS; ENGLAND; ENTERITIS, REGIONAL; FECES; INTESTINAL ABSORPTION; INTESTINE, SMALL; MALABSORPTION SYNDROMES; NITROGEN; PANCREATITIS; POSTGASTRECTOMY SYNDROMES; SERUM ALBUMIN; SODIUM CHLORIDE; SPRUE; STATISTICS; SURGERY, OPERATIVE; TRITIUM