ENDOGENOUS PYROGEN RELEASE FROM RABBIT BLOOD CELLS INCUBATED IN VITRO WITH PARAINFLUENZA VIRUS.
Rabbit blood cells incubated in vitro with purified parainfluenza-5 virus (DA strain) released a rapidly acting pyrogen. Spleen and lymph node cells were inactive. The pyrogen resembled in behavior a pyrogen extracted from granulocytic exudates. Similar cells in the blood are believed to be activated by virus in vivo to produce the circulating endogenous pyrogen that mediates virus-induced fever.
D000818:Animals; D001773:Blood Cells; D066298:In Vitro Techniques; D007375:Interleukin-1; D007962:Leukocytes; D008198:Lymph Nodes; D009975:Orthomyxoviridae; D018184:Paramyxoviridae Infections; D011749:Pyrogens; D011817:Rabbits; D012106:Research; D013154:Spleen
D007375:Interleukin-1; D011749:Pyrogens; C008270:leukocyte endogenous mediator
BLOOD CELLS; EXPERIMENTAL LAB STUDY; PARA-INFLUENZA VIRUSES; PYROGENS; RABBITS