THE RESPIRATORY ACTION OF DICHLORPHENAMIDE.
The action of dichlorphenamide has been investigated in three healthy subjects. After this drug had been given, ventilation increased while alveolar and oxygenated mixed venous Pco(2) both fell. The magnitude of these changes was closely related to the degree of acidosis produced by the drug. The effect of intravenous acetazolamide, tested in one subject, was qualitatively similar to that of orally administered dichlorphenamide. Respiratory responses to carbon dioxide were studied in two of the subjects and in one of them the metabolic acidosis was sufficient to account for the short-term effect of dichlorphenamide on respiration.
D000086:Acetazolamide; D000138:Acidosis; D035843:Biomedical Research; D001784:Blood Gas Analysis; D002245:Carbon Dioxide; D002257:Carbonic Anhydrase Inhibitors; D019069:Cell Respiration; D004005:Dichlorphenamide; D006801:Humans; D010600:Pharmacology; D012119:Respiration; D012131:Respiratory Insufficiency; D014116:Toxicology
D002257:Carbonic Anhydrase Inhibitors; D002245:Carbon Dioxide; D000086:Acetazolamide; D004005:Dichlorphenamide
ACETAZOLAMIDE; ACIDOSIS; BLOOD GAS ANALYSIS; CARBON DIOXIDE; CARBONIC ANHYDRASE INHIBITORS; CLINICAL RESEARCH; DICHLORPHENAMIDE; PHARMACOLOGY; RESPIRATION; RESPIRATORY INSUFFICIENCY; TOXICOLOGIC REPORT