title: THE ANALGESIC PROPERTIES OF SUB-ANAESTHETIC DOSES OF ANAESTHETICS IN THE MOUSE.
abstract: Trichlorethylene in a sub-anaesthetic concentration (0.5% v/v in oxygen) has an analgesic effect on mice, which develops slowly and reaches a maximum roughly equivalent to that produced by 5 mg/kg of methadone hydrochloride given by intraperitoneal injection. Ethyl chloride causes analgesia in sub-anaesthetic concentrations (3%) but is much less potent than trichlorethylene. Halothane (0.75%) produces slight but definite analgesia. Cyclopropane and diethyl ether have no appreciable analgesic effect. Concentrations of nitrous oxide (up to 90%) in oxygen lack any observable analgesic action on the mouse. Trichlorethylene is considerably potentiated by nitrous oxide, its anaesthetic rather than its analgesic action being affected. Nitrous oxide (40%) potentiates the analgesic rather than the anaesthetic action of halothane (0.75%). However, increasing the concentration of nitrous oxide to 60% causes the anaesthetic action of halothane to predominate.
mesh_terms: D000698:Analgesia; D000700:Analgesics; D000758:Anesthesia; D000769:Anesthesia, Inhalation; D000777:Anesthetics; D000818:Animals; D003521:Cyclopropanes; D004594:Electrophysiology; D004986:Ether; D004987:Ethers; D005018:Ethyl Chloride; D006221:Halothane; D008691:Methadone; D051379:Mice; D009609:Nitrous Oxide; D059408:Pain Management; D010600:Pharmacology; D012106:Research; D014241:Trichloroethylene
chemical_list: D000700:Analgesics; D000777:Anesthetics; D003521:Cyclopropanes; D004987:Ethers; D004986:Ether; D014241:Trichloroethylene; D005018:Ethyl Chloride; C030797:cyclopropane; D009609:Nitrous Oxide; D008691:Methadone; D006221:Halothane
keywords: ANALGESIA; ANESTHESIA, INHALATION; CYCLOPROPANE; ELECTROPHYSIOLOGY; ETHYL CHLORIDE; ETHYL ETHER; EXPERIMENTAL LAB STUDY; HALOTHANE; METHADONE; MICE; NITROUS OXIDE; PHARMACOLOGY; TRICHLOROETHYLENE