WATERY DIARRHOEA AND AN ISLET CELL TUMOUR.
It is suggested that there are two hormonal syndromes associated with noninsulin-secreting islet cell tumours and this case is an example of the non-gastrin-secreting type with watery diarrhoea and hypokalaemia. The patient had histamine-fast achlorhydria and a normal gastric biopsy and no gastrin was recovered from the tumour tissue. The watery diarrhoea was isosmotic with plasma and was increased by an intravenous saline load. There was a dramatic response to steroids.
D000126:Achlorhydria; D007516:Adenoma, Islet Cell; D000450:Aldosterone; D003348:Cortisone; D003907:Dexamethasone; D003967:Diarrhea; D005243:Feces; D005755:Gastrins; D006801:Humans; D006996:Hypocalcemia; D007008:Hypokalemia; D009369:Neoplasms / Q000628:therapy*; D010190:Pancreatic Neoplasms; D011188:Potassium; D011241:Prednisone; D012964:Sodium; D013514:Surgical Procedures, Operative; D014556:Urine; D014882:Water-Electrolyte Balance; D015043:Zollinger-Ellison Syndrome
D005755:Gastrins; D000450:Aldosterone; D003907:Dexamethasone; D012964:Sodium; D011188:Potassium; D003348:Cortisone; D011241:Prednisone
ACHLORHYDRIA; ALDOSTERONE; CORTISONE; DEXAMETHASONE; DIARRHEA; FECES; HYPOCALCEMIA; ISLET CELL TUMOR; NEOPLASM THERAPY; PANCREATIC NEOPLASMS; POTASSIUM; PREDNISONE; SODIUM; SURGERY, OPERATIVE; URINE; WATER-ELECTROLYTE BALANCE; ZOLLINGER-ELLISON SYNDROME