title: SEROLOGICAL RESPONSES OF MAN TO TYPHOID VACCINES.
abstract: Study of the serological responses in man to typhoid vaccines tested in several WHO-sponsored controlled field trials in British Guiana, Poland and Yugoslavia has not indicated any correlation between the level of Vi and O antibodies elicited and the effectiveness of the vaccines. Instead, the more effective vaccines have elicited significantly greater H-antibody responses; but a variety of factors suggests that it may in fact not be the antibody that confers immunity to the disease. The phagocytic test does not appear promising as a technique for determining the effectiveness of a typhoid vaccine, but passive protection of the chick-embryo may warrant further investigation.
mesh_terms: D000906:Antibodies; D006172:Guyana; D006384:Hemagglutination; D006801:Humans; D008297:Male; D011044:Poland; D012485:Salmonella typhi; D012760:Shigella; D013223:Statistics as Topic; D014435:Typhoid Fever; D014436:Typhoid-Paratyphoid Vaccines; D014611:Vaccination; D015022:Yugoslavia
chemical_list: D000906:Antibodies; D014436:Typhoid-Paratyphoid Vaccines
keywords: BRITISH GUIANA; HEMAGGLUTINATION; POLAND; SALMONELLA TYPHOSA; SHIGELLA; STATISTICS; TYPHOID; VACCINATION; YUGOSLAVIA