HISTAMINE PROTECTION PRODUCED BY PLANT TUMOUR EXTRACTS. THE ACTIVE PRINCIPLE OF TOMATO PLANTS INFECTED WITH GROWN-GALL.
Guinea-pigs were protected against the lethal effects of a histamine aerosol by intraperitoneal injection of stable extracts of normal tomato plants and of tomato plants infected with crown-gall tumours. The protection was short-lasting. No difference was observed between the activities of extracts of normal and of infected plants. The active principle of the extracts was isolated, and identified as the steroid alkaloid glycoside, tomatine.
D000470:Alkaloids; D000818:Animals; D001686:Biological Phenomena; D006027:Glycosides; D006168:Guinea Pigs; D006632:Histamine; D007274:Injections, Intraperitoneal; D018551:Solanum lycopersicum; D010600:Pharmacology; D010936:Plant Extracts; D010941:Plant Tumors; D010944:Plants; D012106:Research; D014053:Tomatine; D014116:Toxicology
D000470:Alkaloids; D006027:Glycosides; D010936:Plant Extracts; D014053:Tomatine; D006632:Histamine
ALKALOIDS; EXPERIMENTAL LAB STUDY; GLYCOSIDES; GUINEA PIGS; HISTAMINE; PHARMACOLOGY; PLANT TUMORS; TOMATINE; TOXICOLOGIC REPORT