title: STREPTOMYCINOID ANTIBIOTICS: SYNERGISM BY PUROMYCIN.
abstract: Puromycin synergizes the lethal action of streptomycin and related antibiotics. This is interpreted to mean that puromycin action uncovers a sensitive site (or sites) on the 30S ribosome. The streptomycinoid antibiotics can then associate more readily with the ribosome and inhibit further synthesis of valid protein.
mesh_terms: D000900:Anti-Bacterial Agents; D002701:Chloramphenicol; D004926:Escherichia coli; D007612:Kanamycin; D009355:Neomycin; D010303:Paromomycin; D010600:Pharmacology; D011691:Puromycin; D012106:Research; D012270:Ribosomes; D013307:Streptomycin; D014756:Viomycin
chemical_list: D000900:Anti-Bacterial Agents; D011691:Puromycin; D007612:Kanamycin; D010303:Paromomycin; D002701:Chloramphenicol; D009355:Neomycin; D013307:Streptomycin; D014756:Viomycin
keywords: ANTIBIOTICS; CHLORAMPHENICOL; ESCHERICHIA COLI; EXPERIMENTAL LAB STUDY; KANAMYCIN; NEOMYCIN; PAROMOMYCIN; PHARMACOLOGY; PUROMYCIN; RIBOSOMES; STREPTOMYCIN; VIOMYCIN