title: METHOXYFLURANE ANESTHESIA IN PEDIATRICS: A CLINICAL REPORT.
abstract: Methoxyflurane has been used for general anesthesia at The Montreal Children's Hospital since its clinical introduction in 1960, and has been administered to more than 5000 patients undergoing most types of pediatric operations. From a study of the records of more than one-half of these patients, a clinical impression of its usefulness has been obtained.When vapourized in a standard ether apparatus it appears to have the same high degree of safety as ethyl ether. It differs from ether in that it is non-explosive, less noxious and less irritating upon inhalation, depresses ventilation more and produces little postoperative vomiting.While the present trend is to employ more labile or less potent inhalation anesthetics, this development is not completed in children and methoxyflurane is a good modern substitute for ether, if pulmonary ventilation is supported when this is indicated.
mesh_terms: D000759:Adjuvants, Anesthesia; D000293:Adolescent; D000758:Anesthesia / Q000009:adverse effects*; D000768:Anesthesia, General; D000769:Anesthesia, Inhalation; D000776:Anesthesiology; D018685:Anesthetics, Inhalation; D002648:Child; D004986:Ether; D004987:Ethers; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008733:Methoxyflurane; D009609:Nitrous Oxide; D010372:Pediatrics; D012119:Respiration; D014116:Toxicology
chemical_list: D000759:Adjuvants, Anesthesia; D018685:Anesthetics, Inhalation; D004987:Ethers; D004986:Ether; D008733:Methoxyflurane; D009609:Nitrous Oxide
keywords: ADOLESCENCE; ANESTHESIA ADJUVANTS; ANESTHESIA COMPLICATIONS; ANESTHESIA, INHALATION; CHILD; ETHYL ETHER; INFANT; INFANT, NEWBORN; METHOXYFLURANE; NITROUS OXIDE; TOXICOLOGIC REPORT