BACTERIOPHAGES THAT LYSE MYCOBACTERIA AND CORYNEBACTERIA, AND SHOW CYTOPATHOGENIC EFFECT ON TISSUE CULTURES OF RENAL CELLS OF CERCOPITHECUS AETHIOPS: A PRELIMINARY COMMUNICATION.
Bacteriophages isolated from sputum and resection specimens of patients suffering from carcinoma of the lung were found to lyse corynebacteria and mycobacteria, and to produce a cytopathogenic effect on certain cells in tissue cultures. From the same and other patients with neoplastic disease, bacteria were isolated and described as coryne-mycobacteria because of bacteriological features they shared with both species. These bacteria, which either were sensitive to mycobacteriophages and corynebacteriophages or were phage-immune lysogenic bacteria, could be induced to produce lytic particles with phagolytic activity on corynebacteria and mycobacteria and a cytopathogenic effect on HeLa cells and on the renal cells of Cercopithecus.
D002282:Adenocarcinoma, Bronchiolo-Alveolar; D000818:Animals; D001433:Bacteriolysis; D001435:Bacteriophages; D055745:Bronchioles; D002277:Carcinoma; D002522:Chlorocebus aethiops; D003352:Corynebacterium; D003588:Cytopathogenic Effect, Viral; D000882:Haplorhini; D006367:HeLa Cells; D006801:Humans; D008175:Lung Neoplasms; D009160:Mycobacteriophages; D009161:Mycobacterium; D012106:Research; D046509:Tissue Culture Techniques
BACTERIOLYSIS; BACTERIOPHAGE; CARCINOMA, BRONCHIOLAR; CORYNEBACTERIUM; CYTOPATHOGENIC EFFECT, VIRAL; EXPERIMENTAL LAB STUDY; LUNG NEOPLASMS; MONKEYS; MYCOBACTERIOPHAGES; MYCOBACTERIUM; TISSUE CULTURE