TRANSPLANTATION IMMUNITY OF GESTATIONAL ORIGIN IN INFANT RATS.
Comparison of the survival times of homografts of BN skin on 3-day-old Lewis rats born of mothers of the same isogenic strain with those of BN grafts on infant Lewis hosts that had developed in an F(1) (Lewis x BN) hybrid, gave no evidence of maternally induced tolerance as a result of development in an antigenically alien environment. On the contrary, the significantly shorter median survival time of the grafts on the hybrid-derived Lewis group suggests that sensitization had occurred as a consequence of natural exposure during gestation to small numbers of maternal cells.
D000818:Animals; D000831:Animals, Newborn; D000941:Antigens; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D012106:Research; D012867:Skin; D016038:Skin Transplantation; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000941:Antigens
ANIMALS, NEWBORN; EXPERIMENTAL LAB STUDY; IMMUNE TOLERANCE; MATERNAL-FETAL EXCHANGE; PREGNANCY; PREGNANCY, ANIMAL; RATS; SKIN TRANSPLANTATION; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION, HOMOLOGOUS