COMPLEMENT: INACTIVATION OF SECOND COMPONENT BY P-HYDROXYMERCURIBENZOATE.
p-Hydroxymercuribenzoate inactivates the second component of complement whether it is in solution or is fixed to a sensitized erythrocyte together with the first and fourth components. Inactivation by the drug is blocked but not reversed by cysteine. Partial purification of the second component of complement is described.
D001565:Benzoates; D002498:Centrifugation; D011232:Chemical Precipitation; D002845:Chromatography; D003165:Complement System Proteins; D003545:Cysteine; D003956:Dialysis; D004492:Edetic Acid; D006902:Hydroxymercuribenzoates; D007202:Indicators and Reagents; D010600:Pharmacology; D006435:Renal Dialysis; D012106:Research; D012996:Solutions; D013438:Sulfhydryl Compounds
D001565:Benzoates; D006902:Hydroxymercuribenzoates; D007202:Indicators and Reagents; D012996:Solutions; D013438:Sulfhydryl Compounds; C030601:4-hydroxymercuribenzoate; D003165:Complement System Proteins; D004492:Edetic Acid; D003545:Cysteine
BENZOATES; CENTRIFUGATION; CHROMATOGRAPHY; COMPLEMENT; CYSTEINE; DIALYSIS; EDTA; EXPERIMENTAL LAB STUDY; INDICATORS AND REAGENTS; PHARMACOLOGY; PRECIPITATION; SOLUTIONS; SULFHYDRYL COMPOUNDS