A TERATOGENIC EFFECT OF A SULPHONAMIDE IN EXPERIMENTAL ANIMALS.
Sulphamoprine, when given in the diet at levels from 0.025% upwards to pregnant rats and mice, produced abnormalities of eruption of the incisor teeth and of the skull of the offspring. Rabbits are not susceptible to this teratogenic action.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D000830:Animals, Laboratory; D005260:Female; D006801:Humans; D007793:Lagomorpha; D051379:Mice; D010600:Pharmacology; D011247:Pregnancy; D011270:Pregnancy, Animal; D011817:Rabbits; D051381:Rats; D012106:Research; D012886:Skull; D013045:Species Specificity; D013449:Sulfonamides; D064793:Teratogenesis; D013723:Teratogens; D014071:Tooth Abnormalities; D014116:Toxicology
D013449:Sulfonamides; D013723:Teratogens
ABNORMALITIES, DRUG-INDUCED; EXPERIMENTAL LAB STUDY; MICE; PHARMACOLOGY; PREGNANCY; PREGNANCY, ANIMAL; RABBITS; RATS; SKULL; SPECIES SPECIFICITY; SULFONAMIDES; TOOTH ABNORMALITIES; TOXICOLOGIC REPORT