title: INHIBITION OF SYMPATHOMIMETIC EFFECTS ON THE HEART.
abstract: The adrenaline beta-receptor blocking drug, pronethalol, and the sympathomimetic amines, (-)-ephedrine, (-)-amphetamine, dexamphetamine, (-)-Psi-ephedrine and tyramine, inhibited the sympathomimetic effects of butyrylcholine and tyramine on the guinea-pig isolated atrium. Being reversible and noncompetitive, this antagonism was unspecific and not due to blockade of adrenaline receptors, although pronethalol inhibited the effect of noradrenaline competitively.
mesh_terms: D000661:Amphetamine; D000818:Animals; D003913:Dextroamphetamine; D004809:Ephedrine; D004837:Epinephrine; D004983:Ethanolamines; D006168:Guinea Pigs; D006321:Heart; D009638:Norepinephrine; D010600:Pharmacology; D012106:Research; D011984:Sensory Receptor Cells; D013565:Sympatholytics; D013566:Sympathomimetics; D014439:Tyramine
chemical_list: D004983:Ethanolamines; D013565:Sympatholytics; D013566:Sympathomimetics; D000661:Amphetamine; D004809:Ephedrine; D003913:Dextroamphetamine; D009638:Norepinephrine; D014439:Tyramine; C084832:pronethalol; D004837:Epinephrine
keywords: AMPHETAMINE; DEXTRO AMPHETAMINE; EPHEDRINE; EXPERIMENTAL LAB STUDY; GUINEA PIGS; HEART; NOREPINEPHRINE; PHARMACOLOGY; PRONETHALOL; RECEPTORS, NEURAL; SYMPATHOLYTICS; SYMPATHOMIMETICS; TYRAMINE