PROTEIN SYNTHESIS INHIBITION: MECHANISM FOR THE PRODUCTION OF IMPAIRED FAT ABSORPTION.
Treatment of rats with puromycin and acetoxycycloheximide results in a defect in intestinal lipid transport. Under these conditions rats given corn oil accumulate triglyceride within the intestinal cells and fail to develop the normal postprandial hyperlipemia. The observed interference in lipid transport appears to be a consequence of impaired chylomicron formation.
D001692:Biological Transport; D002247:Carbon Isotopes; D002914:Chylomicrons; D004583:Electrons; D005989:Glycerides; D007408:Intestinal Absorption; D050356:Lipid Metabolism; D008853:Microscopy; D008854:Microscopy, Electron; D019308:Palmitic Acid; D010600:Pharmacology; D011506:Proteins / Q000378:metabolism*; D011691:Puromycin; D051381:Rats; D012106:Research; D014280:Triglycerides
D002247:Carbon Isotopes; D002914:Chylomicrons; D005989:Glycerides; D011506:Proteins; D014280:Triglycerides; D019308:Palmitic Acid; D011691:Puromycin
CARBON ISOTOPES; CHYLOMICRONS; EXPERIMENTAL LAB STUDY; GLYCERIDES; INTESTINAL ABSORPTION; LIPID METABOLISM; MICROSCOPY, ELECTRON; PALMITIC ACID; PHARMACOLOGY; PROTEIN METABOLISM; PUROMYCIN; RATS