GENETIC TRANSFER OF STREPTOMYCIN AND AMINOPROPANOLSTREPTOMYCIN RESISTANCE.
von Graevenitz, Alexander (Yale University, New Haven, Conn.). Genetic transfer of streptomycin and aminopropanolstreptomycin resistance. J. Bacteriol. 88:960-964. 1964.-Transduction and conjugation experiments with Staphylococcus aureus and Escherichia coli suggest that resistance to streptomycin (S) and aminopropanolstreptomycin (A) is due to the same mutation arising in a single step at the locus str. The high occurrence of S(r)A(s) cells (1 to 3%) in an S(r)A(r) population was noted. From genetic crosses of S(r)A(s) with S(s)A(s) cells, it can be concluded that there is a suppressor locus su-A adjacent to, but separable by recombination from, the str locus. It modifies the genotype S(r)A(r) to the phenotype S(r)A(s).
D000900:Anti-Bacterial Agents; D001435:Bacteriophages; D003090:Coliphages; D004352:Drug Resistance, Microbial; D004926:Escherichia coli; D009154:Mutation; D012106:Research; D013210:Staphylococcus; D013211:Staphylococcus aureus; D013307:Streptomycin
D000900:Anti-Bacterial Agents; D013307:Streptomycin
ANTIBIOTICS; BACTERIOPHAGE; COLIPHAGES; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; EXPERIMENTAL LAB STUDY; MUTATION; STAPHYLOCOCCUS; STREPTOMYCIN