CHOLESTEROL BIOSYNTHESIS: MEVALONATE SYNTHESIS INHIBITED BY BILE SALTS.
Certain bile salts inhibit biosynthesis of mevalonate from acetate-2-C(14) in normal rat liver homogenates. The physiological control of cholesterol biosynthesis is discussed.
D000085:Acetates; D001647:Bile Acids and Salts; D002784:Cholesterol; D008099:Liver / Q000201:enzymology* / Q000502:physiology*; D008660:Metabolism; D008798:Mevalonic Acid; D010088:Oxidoreductases; D010600:Pharmacology; D051381:Rats; D012106:Research; D012492:Salts; D012995:Solubility
D000085:Acetates; D001647:Bile Acids and Salts; D012492:Salts; D002784:Cholesterol; D010088:Oxidoreductases; D008798:Mevalonic Acid
BILE ACIDS AND SALTS; CHOLESTEROL; EXPERIMENTAL LAB STUDY; LIVER ENZYMOLOGY; LIVER FUNCTION; METABOLISM; MEVALONIC ACID; OXIDOREDUCTASES; PHARMACOLOGY; RATS; SOLUBILITY