CARCINOGENIC AROMATIC HYDROCARBONS: SPECIAL VULNERABILITY OF RATS.
Compared with other species, the rat is unusually vulnerable to polynuclear aromatic hydrocarbons. In the rat, relatively small amounts of carcinogenic aromatics (i) profoundly depress incorporation of thymidine in DNA, (ii) greatly induce menadione reductase in liver, and (iii) then kill the rat.
D000818:Animals; D000831:Animals, Newborn; D001551:Benz(a)Anthracenes; D002273:Carcinogens; D004247:DNA; D005954:Glucosephosphate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D007770:L-Lactate Dehydrogenase; D008099:Liver; D015674:Mammary Neoplasms, Animal; D008325:Mammary Neoplasms, Experimental; D008660:Metabolism; D051379:Mice; D009374:Neoplasms, Experimental; D010088:Oxidoreductases; D010600:Pharmacology; D010734:Phosphogluconate Dehydrogenase; D051381:Rats; D012106:Research; D012377:Rodentia; D013045:Species Specificity; D014116:Toxicology; D014812:Vitamin K
D001551:Benz(a)Anthracenes; D002273:Carcinogens; D014812:Vitamin K; D004247:DNA; C030935:benz(a)anthracene; D010088:Oxidoreductases; D007770:L-Lactate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase
ANIMALS, NEWBORN; BENZANTHRACENES; DNA; EXPERIMENTAL LAB STUDY; GLUCOSEPHOSPHATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE; LACTATE DEHYDROGENASE; MAMMARY NEOPLASMS, EXPERIMENTAL; METABOLISM; MICE; NEOPLASMS, EXPERIMENTAL; OXIDOREDUCTASES; PHARMACOLOGY; PHOSPHOGLUCONATE DEHYDROGENASE; RATS; RODENTS; SPECIES SPECIFICITY; TOXICOLOGIC REPORT; VITAMIN K