REOVIRUS HEMAGGLUTINATION: INHIBITION BY N-ACETYL-D-GLUCOSAMINE.
Purified reoviruses types 1, 2, and 3 were specifically inhibited in their hemagglutination of human erythrocytes by 250 micromoles or more of N-acetyl-D-glucosamine but not by over 20 other sugars tested. N-acetyl-D-glucosamine inhibited reovirus hemaglutination by binding to capsid virus; it did not attach to the erythrocytes. It is possible that reovirus hemagglutination involves union between N-acetyl-D-glucosamine on the surface of the red cell and the glycoprotein of the virus coat.
D000117:Acetylglucosamine; D002241:Carbohydrates; D004912:Erythrocytes; D005944:Glucosamine; D006384:Hemagglutination; D006595:Hexosamines; D006801:Humans; D010600:Pharmacology; D012087:Reoviridae; D012106:Research; D014714:Vertebrates; D014780:Viruses
D002241:Carbohydrates; D006595:Hexosamines; D005944:Glucosamine; D000117:Acetylglucosamine
CARBOHYDRATES; EXPERIMENTAL LAB STUDY; HEMAGGLUTINATION; HEXOSAMINES; PHARMACOLOGY; REOVIRUS; VERTEBRATE VIRUSES