title: CARRIER MODEL FOR ACTIVE TRANSPORT OF IONS ACROSS A MOSAIC MEMBRANE.
abstract: The central purpose of this paper is to elucidate in a well defined system the meaning of certain phenomena and concepts associated with the active transport of ions. To this end a specific model for a carrier system which actively transports a single ionic species is analyzed and discussed in detail. It is assumed in this model that the carrier-mediated ionic transport occurs in regions of the membrane physically separate from those regions in which free ionic movement takes place,-coupling between the active and passive regions of the membrane occurring through local current flows. The model is seen to display the following characteristics: (a) Starting from identical solutions on the two sides of the membrane, there is produced a redistribution of ions; (b) with identical solutions on the two sides of the membrane there exists a potential difference across the membrane, i.e., the "pump" is electrogenic; (c) the "short circuit" current for symmetrical solutions is equal to the flux of the neutral ion carrier complex; (d) the rate of active transport (and hence of metabolism) is dependent on the ionic concentrations in the surrounding solutions. Throughout the paper comparison is made between features of the model and properties displayed by biological active transport systems, but there is no claim of an identity between the two.
mesh_terms: D001692:Biological Transport; D001693:Biological Transport, Active; D002463:Cell Membrane Permeability; D006863:Hydrogen-Ion Concentration; D007474:Ion Exchange; D007477:Ions; D008566:Membranes; D008962:Models, Theoretical; D010827:Physiology; D012106:Research; D012996:Solutions
chemical_list: D007477:Ions; D012996:Solutions
keywords: CELL MEMBRANE PERMEABILITY; EXPERIMENTAL LAB STUDY; ION EXCHANGE; PHYSIOLOGY