STIMULANT EFFECTS OF A SULFONAMIDE PREPARATION, SULFAPHENAZOLE, ON THE CENTRAL NERVOUS SYSTEM IN RATS.
Sulfaphenazole (Orisul), which had been reported to cause a convulsant syndrome in young European children, lowered the electroshock threshold in rats when administered in the form of tablets or suspension. This effect was not obtained with a sample of sulfaphenazole pure drug or with several other long-acting oral sulfonamide preparations, but was obtained with a mixture of impurities which had been found in the same lot of Orisul that had reportedly caused the convulsant syndrome. A change in the method of manufacture now provides a product which is free from these impurities.
D002490:Central Nervous System; D002491:Central Nervous System Agents; D000697:Central Nervous System Stimulants; D003292:Convulsants; D010600:Pharmacology; D051381:Rats; D012106:Research; D013426:Sulfaphenazole; D013449:Sulfonamides
D002491:Central Nervous System Agents; D000697:Central Nervous System Stimulants; D003292:Convulsants; D013449:Sulfonamides; D013426:Sulfaphenazole
CENTRAL NERVOUS SYSTEM; EXPERIMENTAL LAB STUDY; PHARMACOLOGY; RATS; SULFAPHENAZOLE; SULFONAMIDES