title: DIHYDROSTREPTOMYCIN, VITAMIN K2-COUPLED TETRAZOLIUM REDUCTION, AND OXIDATIVE PHOSPHORYLATION IN ESCHERICHIA COLI.
abstract: Bragg, P. D. (University of British Columbia, Vancouver, B.C., Canada). Dihydrostreptomycin, vitamin K(2)-coupled tetrazolium reduction, and oxidative phosphorylation in Escherichia coli. J. Bacteriol. 88:1019-1023. 1964.-Dihydrostreptomycin inhibited the vitamin K(2)-coupled pyruvate-triphenyltetrazolium (TTC) reductase system in extracts from antibiotic-sensitive cells, but stimulated this reaction with extracts from a dependent mutant. The effects of nucleotides, phosphate, and uncoupling agents on the vitamin K(2)-TTC system are consistent with the linkage of reduction of the dye through intermediates of oxidative phosphorylation.
mesh_terms: D000900:Anti-Bacterial Agents; D002170:Canada; D004096:Dihydrostreptomycin Sulfate; D004791:Enzyme Inhibitors; D004926:Escherichia coli; D008660:Metabolism; D009711:Nucleotides; D010085:Oxidative Phosphorylation; D010088:Oxidoreductases; D010600:Pharmacology; D011773:Pyruvates; D012106:Research; D012176:Retinoids; D013778:Tetrazolium Salts; D014812:Vitamin K; D024482:Vitamin K 2
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D009711:Nucleotides; D011773:Pyruvates; D012176:Retinoids; D013778:Tetrazolium Salts; D024482:Vitamin K 2; D014812:Vitamin K; C009591:triphenyltetrazolium; D010088:Oxidoreductases; D004096:Dihydrostreptomycin Sulfate
keywords: DIHYDROSTREPTOMYCIN; ENZYME INHIBITORS; ESCHERICHIA COLI; EXPERIMENTAL LAB STUDY; METABOLISM; NUCLEOTIDES; OXIDATIVE PHOSPHORYLATION; OXIDOREDUCTASES; PHARMACOLOGY; TETRAZOLIUM SALTS; VITAMIN K