GLYCOPROTEIN BIOSYNTHESIS IN HUMAN RETICULOCYTES: A LESION IN THALASSEMIA.
The rate of incorporation of glucosamine into the glycoprotein of reticulocyte stroma is greatly increased in thalassemia. This increase suggests a major enzymic disorder in the buildup of cellular membrane and reconciles the accumulation of material showing a positive reaction with periodic acid Schiff reagent with the clinical picture of oligocythemia and microcytosis.
D050260:Carbohydrate Metabolism; D002462:Cell Membrane; D006023:Glycoproteins; D006801:Humans; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism*; D012156:Reticulocytes; D013789:Thalassemia
D006023:Glycoproteins; D011506:Proteins
CARBOHYDRATE METABOLISM; CELL MEMBRANE; GLYCOPROTEINS; PROTEIN METABOLISM; RETICULOCYTES; THALASSEMIA