title: PROTEIN STRUCTURE RELATIONSHIPS REVEALED BY MUTATIONAL ANALYSIS.
abstract: Studies of tryptophan synthetase A-protein mutants have shown a structural relationship between the positions of amino acid changes associated with forward mutations and second-site reverse mutations.
mesh_terms: D000596:Amino Acids; D001426:Bacterial Proteins; D055598:Chemical Phenomena; D002621:Chemistry; D004926:Escherichia coli; D008025:Ligases; D009154:Mutation; D011506:Proteins; D012106:Research
chemical_list: D000596:Amino Acids; D001426:Bacterial Proteins; D011506:Proteins; D008025:Ligases
keywords: AMINO ACIDS; BACTERIAL PROTEINS; CHEMISTRY; ESCHERICHIA COLI; EXPERIMENTAL LAB STUDY; LIGASES; MUTATION