title: MUTAGENICITY OF A MONOFUNCTIONAL ALKYLATING AGENT DERIVATIVE OF ACRIDINE IN NEUROSPORA.
abstract: Purple adenine (ad-3) mutants induced in Neurospora crassa by 2-methoxy-6-chloro-9-(3-[ethyl-2-chloroethyl] aminopropylamino) acridine dihydrochloride (ICR-170) result from intragenic alterations. They are further characterized by low frequencies of leakiness, allelic complementation, and nonpolarized complementation patterns. These characteristics distinguish them from ad-3 mutants induced by x-rays, nitrous acid, and 2-aminopurine.
mesh_terms: D000166:Acridines; D000225:Adenine; D000477:Alkylating Agents; D000483:Alleles; D000609:Aminoacridines; D055598:Chemical Phenomena; D002621:Chemistry; D009153:Mutagens; D009154:Mutation; D009491:Neurospora; D009492:Neurospora crassa; D009588:Nitrogen Mustard Compounds; D010600:Pharmacology; D012106:Research
chemical_list: D000166:Acridines; D000477:Alkylating Agents; D000609:Aminoacridines; D009153:Mutagens; D009588:Nitrogen Mustard Compounds; C091910:acridine mustard; D000225:Adenine
keywords: ACRIDINES; ALKYLATING AGENTS; CHEMISTRY; EXPERIMENTAL LAB STUDY; MUTATION; NEUROSPORA; NITROGEN MUSTARD COMPOUNDS; PHARMACOLOGY