title: VIRULENCE-LINKED COLONIAL AND MORPHOLOGICAL VARIATION IN LEPTOSPIRA.
abstract: Faine, S. (University of Sydney, Sydney, Australia), and J. van der Hoeden. Virulence-linked colonial and morphological variation in Leptospira. J. Bacteriol. 88:1493-1496. 1964.-Large-colony typical hooked Leptospira icterohaemorrhagiae was virulent for hamsters and guinea pigs. On cultivation, it was gradually replaced by a serologically identical small-colony avirulent straight mutant. The hooked virulent form was selected in vivo.
mesh_terms: D000818:Animals; D001315:Australia; D006224:Cricetinae; D006168:Guinea Pigs; D007919:Leptospira; D041383:Leptospira interrogans serovar icterohaemorrhagiae; D007922:Leptospirosis; D009154:Mutation; D012106:Research; D014774:Virulence
keywords: EXPERIMENTAL LAB STUDY; GUINEA PIGS; HAMSTERS; LEPTOSPIRA ICTEROHAEMORRHAGIAE; LEPTOSPIROSIS; MUTATION; VIRULENCE