FUNCTIONAL STUDIES OF CULTURED BRAIN TISSUES AS RELATED TO "DEMYELINATIVE DISORDERS".
The serums from animals with experimental allergic encephalomyelitis and humans with multiple sclerosis produce, in addition to demyelination, rapid, reversible alterations in complex, evoked bioelectric (synaptic) responses of cultured cerebral cortex and spinal cord tissues of the mouse. The active factors are dependent on complement and are not present in serums from normal animals and humans.
D000818:Animals; D000831:Animals, Newborn; D001769:Blood; D001921:Brain / Q000502:physiology*; D002540:Cerebral Cortex; D003165:Complement System Proteins; D003711:Demyelinating Diseases; D004558:Electric Stimulation; D004594:Electrophysiology; D004679:Encephalomyelitis; D004681:Encephalomyelitis, Autoimmune, Experimental; D006801:Humans; D006967:Hypersensitivity; D007159:Immunologic Tests; D051379:Mice; D009103:Multiple Sclerosis; D010600:Pharmacology; D012106:Research; D013116:Spinal Cord; D046509:Tissue Culture Techniques
D003165:Complement System Proteins
ANIMALS, NEWBORN; BLOOD; BRAIN ELECTROPHYSIOLOGY; CEREBRAL CORTEX; COMPLEMENT; DEMYELINATION; ELECTRIC STIMULATION; ENCEPHALOMYELITIS; ENCEPHALOMYELITIS, ALLERGIC; EXPERIMENTAL LAB STUDY; HYPERSENSITIVITY; MICE; MULTIPLE SCLEROSIS; PHARMACOLOGY; SPINAL CORD; TISSUE CULTURE