ABROGATION OF ALLOGENEIC INHIBITION BY CORTISONE.
Tumor cells from homozygous mice grow better upon transplanation to syngeneic mice than to F(1) hybrids between the tumor strain and a foreign strain. The inhibition of cell growth in the hybrids (called allogeneic inhibition), which is detected by tumor transplantation into mice, cotuld be abrogated by treatment of the recipient mice with cortisone acetate. Cortisone also abolished allogeneic inhibition in vitro; abolition was detected by treating tumor cultures with cell extracts containing foreign isoantigens of the H-2 type.
D000818:Animals; D000941:Antigens; D003348:Cortisone; D005823:Genetics; D007519:Isoantigens; D051379:Mice; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000276:immunology*; D010600:Pharmacology; D012106:Research; D012509:Sarcoma; D012513:Sarcoma, Experimental; D046509:Tissue Culture Techniques
D000941:Antigens; D007519:Isoantigens; D003348:Cortisone
ANTIGENS; CORTISONE; EXPERIMENTAL LAB STUDY; GENETICS; ISOANTIGENS; MICE; NEOPLASM IMMUNOLOGY; NEOPLASM TRANSPLANTATION; PHARMACOLOGY; SARCOMA, EXPERIMENTAL; TISSUE CULTURE