PARTICLES RESEMBLING PAPOVA VIRUSES IN HUMAN CEREBRAL DEMYELINATING DISEASE.
Degenerated brain tissue obtained from a deceased patient who had progressive multifocal leukoencephalopathy had been fixed in formalin prior to processing for electron microscopy. In ultrathin sections virus-like particles resembling papova virions were frequently observed in glial nuclei. Correlation with light-microscopy findings suggests that demyelination resulted from the cytocidal effect of the virus on oligodendroglia.
D001927:Brain Diseases; D002467:Cell Nucleus; D004267:DNA Viruses; D003711:Demyelinating Diseases; D004583:Electrons; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal; D008853:Microscopy; D008854:Microscopy, Electron; D009457:Neuroglia; D009836:Oligodendroglia; D009858:Oncogenic Viruses; D010336:Pathology; D014777:Virus Diseases; D014780:Viruses
DEMYELINATION; MICROSCOPY, ELECTRON; NEUROGLIA; PAPOVAVIRUS; PATHOLOGY; VIRUS DISEASES