CONTROL OF ENZYME ACTIVITY IN GROWING BACTERIAL CELLS BY CONCERTED FEEDBACK INHIBITION.
Amino acids of the aspartic acid family are synthesized in bacteria through a multistep branched pathway. In the photosynthetic bacterium Rhodopseudomonas capsulatus, the enzyme that catalyzes the first step is specifically inhibited by a combination of two end-product amino acids. Evidence is presented for operation of this kind of "concerted" feedback control as a regulatory device in growing cells.
D000429:Alcohol Oxidoreductases; D000596:Amino Acids / Q000378:metabolism*; D001224:Aspartic Acid; D004798:Enzymes; D005246:Feedback; D008239:Lysine; D008715:Methionine; D010770:Phosphotransferases; D012106:Research; D012241:Rhodopseudomonas; D013912:Threonine
D000596:Amino Acids; D004798:Enzymes; D013912:Threonine; D001224:Aspartic Acid; D008715:Methionine; D000429:Alcohol Oxidoreductases; D010770:Phosphotransferases; D008239:Lysine
ALCOHOL OXIDOREDUCTASES; AMINO ACID METABOLISM; ENZYMES; EXPERIMENTAL LAB STUDY; FEEDBACK; LYSINE; METHIONINE; PHOSPHOTRANSFERASES; RHODOPSEUDOMONAS; THREONINE