A SOLUBLE PRECIPITATING ANTIGEN (HCA) FROM HOG CHOLERA VIRUS PROPAGATED IN TISSUE CULTURE. II. INCIDENCE OF HCA-ANTIBODIES IN SERA OF HOG CHOLERA-IMMUNE AND NONIMMUNE SWINE.
Some conditions are presented under which swine develop antibodies for a soluble hog cholera viral antigen (HCA). Precipitating antibodies for HCA were present in all of the immune and hyperimmune anti-hog cholera sera tested. Antibodies for HCA could not be detected in the sera from a large number of swine after vaccination with inactivated hog cholera virus. Many of these same swine did produce HCA-antibodies following challenge with virulent virus. The incidence of these antibodies was significantly higher 3 weeks to one month after challenge than at 10 days. About one-fourth of a smaller group of swine developed HCA-antibodies after vaccination with modified active hog cholera virus vaccine. Exposure to active hog cholera virus appears prerequisite for swine to develop HCA-antibodies.
D000818:Animals; D000906:Antibodies; D000914:Antibodies, Viral; D000917:Antibody Formation; D000956:Antigens, Viral; D006691:Classical Swine Fever; D006692:Classical Swine Fever Virus; D007106:Immune Sera; D007159:Immunologic Tests; D015994:Incidence; D012098:Reproduction; D012106:Research; D013552:Swine; D046509:Tissue Culture Techniques; D014611:Vaccination; D014612:Vaccines; D014765:Viral Vaccines
D000906:Antibodies; D000914:Antibodies, Viral; D000956:Antigens, Viral; D007106:Immune Sera; D014612:Vaccines; D014765:Viral Vaccines
ANTIBODY FORMATION; EXPERIMENTAL LAB STUDY; HOG CHOLERA; IMMUNE SERUMS; SWINE; TISSUE CULTURE; VIRAL VACCINES