TRYPTAMINE OXIDATION BY EXTRACTS OF PEA SEEDLINGS: EFFECT OF GROWTH RETARDANT BETA-HYDROXYETHYLHYDRAZINE.
beta-Hydroxyethylhydrazine forces flowering of pineapple plants, possibly by reducing auxin concentration. A specific and sensitive assay showed that beta-hydroxyethylhydrazine (3.3 x 10(-7)M) inhibits noncompetitively and almost completely the oxidation of tryptamine to indoleacetaldehyde by extracts of pea-seedling (Pisum sativum L. var. Alaska). The relative rate of oxidation of putrescine to Delta(1)-pyrroline compared to that of tryptamine by these extracts and the inhibition of both reactions by beta-hydroxyethylhydrazine suggest that diamine oxidase is inhibited. beta-Hydroxyethylhydrazine is a potent inhibitor in vivo of animal diamine oxidase.
D000413:Alaska; D006631:Amine Oxidase (Copper-Containing); D000818:Animals; D004791:Enzyme Inhibitors; D006834:Hydrazines; D007211:Indoles; D010084:Oxidation-Reduction; D018532:Pisum sativum; D010600:Pharmacology; D010944:Plants; D011700:Putrescine; D011758:Pyrroles; D012106:Research; D036226:Seedlings; D014363:Tryptamines
D004791:Enzyme Inhibitors; D006834:Hydrazines; D007211:Indoles; D011758:Pyrroles; D014363:Tryptamines; C001655:indole-3-acetaldehyde; C025565:delta(1)-pyrroline; C030820:tryptamine; C037834:2-hydroxyethylhydrazine; D006631:Amine Oxidase (Copper-Containing); D011700:Putrescine
ENZYME INHIBITORS; EXPERIMENTAL LAB STUDY; HISTAMINASE; HYDRAZINES; INDOLES; PHARMACOLOGY; PLANTS; TRYPTAMINES