IMMUNOLOGIC TOLERANCE IN THYMECTOMIZED, IRRADIATED RATS GRAFTED WITH THYMUS FROM TOLERANT DONORS.
Lewis rats, thymectomized at 5 weeks of age and irradiated at 8 weeks, received grafts of adult thymus and marrow, one or both grafts being derived from donors tolerant to bovine gamma-globulin. Challenge 3 or 6 weeks after grafting showed that delayed sensitization could not be induced in animals which received a tolerant thymus or tolerant thymus and marrow, though sensitization to a heterologous antigen (chicken ovalbumin) occurred normally. Arthus reactivity was regained slowly in animals receiving normal thymus and marrow and, to an equal extent, in those receiving grafts from tolerant donors.
D000707:Anaphylaxis; D000818:Animals; D000917:Antibody Formation; D001183:Arthus Reaction; D001853:Bone Marrow; D016026:Bone Marrow Transplantation; D007108:Immune Tolerance; D010047:Ovalbumin; D011830:Radiation Effects / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D012106:Research; D012882:Skin Tests; D013934:Thymectomy; D013950:Thymus Gland; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D010047:Ovalbumin
ANAPHYLAXIS; ANTIBODY FORMATION; ARTHUS PHENOMENON; BONE MARROW TRANSPLANTATION; EXPERIMENTAL LAB STUDY; IMMUNE TOLERANCE; OVALBUMIN; RADIATION IMMUNOLOGY; SKIN TESTS; THYMECTOMY; THYMUS GLAND; TRANSPLANTATION, HOMOLOGOUS