GALLSTONES PRODUCED EXPERIMENTALLY BY LITHOCHOLIC ACID IN RATS.
Administration of lithocholic acid (1 percent in the diet) consistently produces choledocholithiasis in 8 weeks in rats on an 8-percent protein diet. The gallstones consist predominantly of the calcium salts of free and glycine-conjugated lithocholic and 3alpha,6beta-dihydroxy-5beta-cholanic acids. Conjugation of bile acid with taurine can be enhanced and stone formation can be inhibited by an increase in the dietary protein or by a diet supplemented with taurine.
D001647:Bile Acids and Salts; D004032:Diet; D004044:Dietary Proteins; D042882:Gallstones; D005998:Glycine; D008095:Lithocholic Acid; D008099:Liver; D010600:Pharmacology; D051381:Rats; D012106:Research; D012492:Salts; D013654:Taurine; D014116:Toxicology
D001647:Bile Acids and Salts; D004044:Dietary Proteins; D012492:Salts; D013654:Taurine; D008095:Lithocholic Acid; D005998:Glycine
BILE ACIDS AND SALTS; COMMON BILE DUCT CALCULI; DIETARY PROTEINS; EXPERIMENTAL LAB STUDY; PHARMACOLOGY; RATS; TAURINE; TOXICOLOGIC REPORT