LYSIS OF BACTERIAL PROTOPLASTS AND SPHEROPLASTS BY STAPHYLOCOCCAL ALPHA-TOXIN AND STREPTOLYSIN S.
Bernheimer, Alan W. (New York University School of Medicine, New York, N.Y.), and Lois L. Schwartz. Lysis of bacterial protoplasts and spheroplasts by staphylococcal alpha-toxin and streptolysin S. J. Bacteriol. 89:1387-1392. 1965.-Protoplasts of Bacillus megaterium, Sarcina lutea, and Streptococcus pyogenes, and spheroplasts of Escherichia coli were lysed by staphylococcal alpha-toxin, whereas spheroplasts of Vibrio metschnikovii and V. comma were not. In the spectrum of its lytic action, streptolysin S qualitatively resembled staphylococcal alpha-toxin except for failure to lyse S. pyogenes protoplasts. In contrast to the two foregoing agents, streptolysin O did not lyse protoplasts and spheroplasts. The observations are interpreted in relation to similarities and differences in lipid composition of bacterial and mammalian cell membranes.
D000818:Animals; D000992:Antitoxins; D001410:Bacillus megaterium; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D001433:Bacteriolysis; D002463:Cell Membrane Permeability; D004926:Escherichia coli; D006460:Hemolysin Proteins; D009113:Muramidase; D010406:Penicillins; D010600:Pharmacology; D011523:Protoplasts; D012106:Research; D012505:Sarcina; D013104:Spheroplasts; D013210:Staphylococcus; D013297:Streptococcus pyogenes; D013301:Streptolysins; D014118:Toxins, Biological; D014733:Vibrio
D000992:Antitoxins; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D006460:Hemolysin Proteins; D010406:Penicillins; D013301:Streptolysins; D014118:Toxins, Biological; C021091:staphylococcal alpha-toxin; C025964:streptolysin O; C026050:streptolysin S; D009113:Muramidase
BACILLUS MEGATERIUM; BACTERIOLYSIS; CELL MEMBRANE PERMEABILITY; ESCHERICHIA COLI; EXPERIMENTAL LAB STUDY; MURAMIDASE; PENICILLIN; PHARMACOLOGY; PROTOPLASTS; SARCINA; STAPHYLOCOCCUS; STREPTOCOCCUS PYOGENES; STREPTOLYSIN; TOXINS AND ANTITOXINS; VIBRIO