SEROTONIN: SYNTHESIS AND RELEASE FROM THE MYENTERIC PLEXUS OF THE MOUSE INTESTINE.
After injection of its radioactive precursor, 5-hydroxytryptophan, radioactive serotonin was biosynthesized and bound in the myenteric plexus of the mouse intestine. Addition of nonradioactive serotonin to preparations in vitro caused a net release of radioactive serotonin from the plexus. This release appeared to result from activity in the intramural nervous system of the intestine. A neurotransmitter role between sensory and motor neurons in the peristaltic reflex pathway is suggested as a working hypothesis to explain the action of serotonin.
D006916:5-Hydroxytryptophan; D000818:Animals; D002247:Carbon Isotopes; D002845:Chromatography; D005769:Gastrointestinal Motility; D007422:Intestines; D008660:Metabolism; D051379:Mice; D009197:Myenteric Plexus; D018377:Neurotransmitter Agents; D010827:Physiology; D012106:Research; D012701:Serotonin; D014316:Tritium
D002247:Carbon Isotopes; D018377:Neurotransmitter Agents; D014316:Tritium; D012701:Serotonin; D006916:5-Hydroxytryptophan
CARBON ISOTOPES; CHROMATOGRAPHY; EXPERIMENTAL LAB STUDY; GASTROINTESTINAL MOTILITY; HYDROXYTRYPTOPHAN; METABOLISM; MICE; MYENTERIC PLEXUS; PHYSIOLOGY; SEROTONIN; TRITIUM