PATHOGENESIS OF INFLAMMATION. II. IN VIVO OBSERVATIONS OF THE INFLAMMATORY EFFECTS OF ACTIVATED HAGEMAN FACTOR AND BRADYKININ.
Activated Hageman factor, when injected into the rabbit ear chamber, produces a delayed and prolonged inflammatory response characterized by prominent sticking and emigration of leucocytes. In contrast, preformed bradykinin evokes an immediate and more transient response in which leucocytic emigration occurs less frequently. It is concluded that either Hageman factor produces its inflammatory effects by mechanisms other than kinin release, or bradykinin released endogenously has effects quite different from those resulting from a single injection of the exogenous material.
D000818:Animals; D001713:Biphenyl Compounds; D001779:Blood Coagulation Factors; D001920:Bradykinin; D002199:Capillary Permeability; D005174:Factor XII; D007249:Inflammation; D007962:Leukocytes; D010600:Pharmacology; D010827:Physiology; D011817:Rabbits; D012106:Research
D001713:Biphenyl Compounds; D001779:Blood Coagulation Factors; D005174:Factor XII; D001920:Bradykinin
BIPHENYL COMPOUNDS; BLOOD COAGULATION FACTORS; BRADYKININ; CAPILLARY PERMEABILITY; EXPERIMENTAL LAB STUDY; FACTOR XII; INFLAMMATION; LEUKOCYTES; PHARMACOLOGY; PHYSIOLOGY; RABBITS