PRURITUS AND JAUNDICE.
The records of 147 patients who had pruritus and jaundice (11% of a series of 1262 patients with jaundice) were reviewed in an effort to delineate more clearly the etiology of jaundice associated with pruritus.Fifty-two had obstructive jaundice caused by neoplasm, 51 had obstructive jaundice not caused by neoplasm, 42 had pruritus associated with hepatogenous jaundice, and two had jaundice and pruritus associated with a lymphoma.Pruritus occurred in 17% of all patients with non-neoplastic obstructive jaundice and in 45% of patients with neoplastic obstructive jaundice. Hepatogenous jaundice was the cause of pruritus in almost one-third of the patients in this series-occurring in 20% of patients with infectious hepatitis and in 7% of patients with cirrhosis.This large series confirms the clinical impression that pruritus occurs most often in association with extrahepatic biliary obstruction, and as well re-emphasizes the common association of pruritus with hepatogenous jaundice.
D001650:Bile Duct Neoplasms; D002769:Cholelithiasis; D003933:Diagnosis; D005706:Gallbladder Neoplasms; D006505:Hepatitis; D006506:Hepatitis A; D006801:Humans; D007565:Jaundice; D041781:Jaundice, Obstructive; D008103:Liver Cirrhosis; D008113:Liver Neoplasms; D010190:Pancreatic Neoplasms; D011537:Pruritus
BILE DUCT NEOPLASMS; CHOLELITHIASIS; DIAGNOSIS; GALLBLADDER NEOPLASMS; HEPATITIS; JAUNDICE; JAUNDICE, OBSTRUCTIVE; LIVER CIRRHOSIS; PANCREATIC NEOPLASMS; PRURITUS