FIBROGEN PRECIPITATION BY STREPTOCOCCAL M PROTEIN. II. RENAL LESIONS INDUCED BY INTRAVENOUS INJECTION OF M PROTEIN INTO MICE AND RATS.
Intravenous injection of Type 1 streptococcal M protein into mice and rats produced lesions confined to renal glomeruli. Thrombi of eosinophilic amorphous material, seen to occlude glomerular capillaries, were shown to contain M protein and fibrinogen. Gradual regression of the morphological lesions was observed during the 3 weeks following injection. Initial abnormal proteinuria and azotemia returned to control levels by the end of the 1st week; a second rise in urinary protein excretion and urea retention was demonstrated in some rats coincident with appearance of anti-M antibodies. The mechanism of renal localization of streptococcal M protein by means of a complex with fibrinogen was suggested, which may comprise an initial phase in the pathogenesis of acute poststreptococcal glomerulonephritis.
D000818:Animals; D000906:Antibodies; D000888:Antibodies, Anti-Idiotypic; D000937:Antigen-Antibody Reactions; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D005340:Fibrinogen; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis; D007275:Injections, Intravenous; D007668:Kidney; D007678:Kidney Glomerulus; D051379:Mice; D009194:Myeloma Proteins; D010336:Pathology; D011507:Proteinuria; D051381:Rats; D012106:Research; D013291:Streptococcus; D013927:Thrombosis; D014116:Toxicology
D000906:Antibodies; D000888:Antibodies, Anti-Idiotypic; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D009194:Myeloma Proteins; C085016:multiple myeloma M-proteins; C014689:streptococcal M protein; D005340:Fibrinogen
ANTIGEN-ANTIBODY REACTIONS; BACTERIAL PROTEINS; EXPERIMENTAL LAB STUDY; FIBRINOGEN; FLUORESCENT ANTIBODY TECHNIC; GLOMERULONEPHRITIS; MICE; PATHOLOGY; RATS; STREPTOCOCCUS; THROMBOSIS; TOXICOLOGIC REPORT