ADENOSYLMETHIONINE ELEVATION IN LEUKEMIC WHITE BLOOD CELLS.
White blood cell preparations from patients with chronic myelocytic leukemia have more S-adenosylmethionine, an important metabolic intermediate, than normal peripheral white cells or thoracic-duct lymphocytes. The previously reported elevation of cyanocobalamine (vitamin B(l2)) in the serum of patients with this disease is corroborated. The possible usefulness of methylation antimetabolites in cancer chemotherapy is suggested.
D000963:Antimetabolites; D001669:Biochemical Phenomena; D001671:Biochemistry; D004358:Drug Therapy; D006801:Humans; D007938:Leukemia; D007951:Leukemia, Myeloid; D007958:Leukocyte Count; D007962:Leukocytes; D008214:Lymphocytes; D008715:Methionine; D009705:Nucleosides; D012436:S-Adenosylmethionine; D014805:Vitamin B 12
D000963:Antimetabolites; D009705:Nucleosides; D012436:S-Adenosylmethionine; D008715:Methionine; D014805:Vitamin B 12
ANTIMETABOLITES; BIOCHEMISTRY; DRUG THERAPY; LEUKEMIA, MYELOCYTIC; LYMPHOCYTES; METHIONINE; NUCLEOSIDES; VITAMIN B 12