BIOCHEMICAL STUDIES OF TOXIC AGENTS. THE METABOLISM OF IODOMETHANE.
1. The metabolism of iodomethane has been studied after the administration of the compound to rats by subcutaneous injection. 2. The urinary excretion of S-methylcysteine, methylmercapturic acid, methylthioacetic acid and N-(methylthioacetyl)glycine has been demonstrated by paper chromatography. 3. Methylmercapturic acid and N-(methylthioacetyl)glycine have been isolated from the urine of the dosed animals. 4. The methylthio compounds detected represented about 2% of the iodomethane administered.
D000818:Animals; D002845:Chromatography; D002854:Chromatography, Paper; D003545:Cysteine / Q000031:analogs & derivatives; D005441:Fluids and Secretions; D005998:Glycine; D006847:Hydrocarbons, Iodinated; D007454:Iodides; D008660:Metabolism; D051381:Rats; D012106:Research; D013438:Sulfhydryl Compounds; D014556:Urine
D006847:Hydrocarbons, Iodinated; D007454:Iodides; D013438:Sulfhydryl Compounds; C008425:S-methylcysteine; C014055:methyl iodide; D003545:Cysteine; C017507:mecysteine; D005998:Glycine
CHROMATOGRAPHY; EXCRETION; EXPERIMENTAL LAB STUDY; IODIDES; METABOLISM; RATS; SULFHYDRYL COMPOUNDS; URINE