METABOLISM OF IODINE-131--LABELED THYROXINE-BINDING PREALBUMIN IN MAN.
The metabolism of (131)I-labeled thyroxine-binding prealbumin was studied in four normal subjects and in five hospitalized patients with nonthyroidal disease. The average half-time of total-body thyroxine-binding prealbumin, calculated on the basis of a two-compartmental model, was 1.90 daysin normal subjects. Increased fractional degradation or diminished synthesis, or both, contributed to the depression of thyroxine-binding prealbumin in the serum of patients with nonthyroidal disorders.
D006801:Humans; D007159:Immunologic Tests; D007455:Iodine; D008297:Male; D011228:Prealbumin; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D011868:Radioisotopes; D012709:Serum Albumin; D012711:Serum Albumin, Radio-Iodinated; D013974:Thyroxine; D013975:Thyroxine-Binding Proteins
D011228:Prealbumin; D011506:Proteins; D011868:Radioisotopes; D012709:Serum Albumin; D012711:Serum Albumin, Radio-Iodinated; D013975:Thyroxine-Binding Proteins; D007455:Iodine; D013974:Thyroxine
PROTEIN BINDING; PROTEIN METABOLISM; SERUM ALBUMIN, RADIO-IODINATED; THYROXINE