EFFECT OF 6-MERCAPTOPURINE (6-MP) ON DIFFERENT CLASSES OF ANTIBODY.
In the primary response of mice and rabbits immunized with foreign red cells, 6-MP administration prolonged the formation of 19S antibody. 7S antibody formation was delayed and reduced in these animals. Animals treated with 6-MP during primary response exhibited a preferential 19S response when challenged in the anamnestic response. Animals immunized with small doses of antigen and treated with 6-MP only during the secondary response, reversed the usual antibody pattern and responded with preferential 19S antibody formation.
D000818:Animals; D000906:Antibodies; D000917:Antibody Formation; D000941:Antigens; D002845:Chromatography; D004912:Erythrocytes; D007114:Immunization; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015122:Mercaptopurine; D051379:Mice; D010600:Pharmacology; D011817:Rabbits; D012106:Research; D014461:Ultracentrifugation; D005719:gamma-Globulins
D000906:Antibodies; D000941:Antigens; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005719:gamma-Globulins; D015122:Mercaptopurine
ANTIBODIES; ANTIBODY FORMATION; ANTIGENS; CHROMATOGRAPHY; EXPERIMENTAL LAB STUDY; GAMMA GLOBULIN, 19S; GAMMA GLOBULIN, 7S; MERCAPTOPURINE; MICE; PHARMACOLOGY; RABBITS; ULTRACENTRIFUGATION