LEUKOCYTES AND INTERFERON IN THE HOST RESPONSE TO VIRAL INFECTIONS. I. MOUSE LEUKOCYTES AND LEUKOCYTE-PRODUCED INTERFERON IN VACCINIA VIRUS INFECTION IN VITRO.
1. Investigation of the role of leukocytes in vaccinia virus infection is reported in an in vitro model, in the absence of an immune response. 2. Mouse leukocytes were shown to be capable of inhibiting the progression of vaccinia virus infection in primary mouse embryo fibroblast cultures. The degree of protection varied from slowing of spread of infection to complete control of the infection with eventual elimination of detectable virus and recovery of the culture. 3. Interferon production by leukocytes is thought to be an important factor in the observed protective effect.
D002642:Chick Embryo; D005347:Fibroblasts; D066298:In Vitro Techniques; D007372:Interferons; D007962:Leukocytes; D051379:Mice; D008962:Models, Theoretical; D010587:Phagocytosis; D012106:Research; D046509:Tissue Culture Techniques; D014357:Trypsin; D014616:Vaccinia virus; D014776:Virus Cultivation
D007372:Interferons; D014357:Trypsin
CHICK EMBRYO; EXPERIMENTAL LAB STUDY; FIBROBLASTS; INTERFERON; LEUKOCYTES; MICE; MODELS, THEORETICAL; PHAGOCYTOSIS; TISSUE CULTURE; TRYPSIN; VACCINIA VIRUS; VIRUS CULTIVATION