ADAPTIVE ENZYME SYNTHESIS: ITS INHIBITION AS A POSSIBLE ANALOGUE OF IMMUOLOGICAL TOLERANCE.
Substrate induction of tryptophan pyrrolase in the liver of rats is inhibited by prior treatment of very young rats with tryptophan. This inhibition seems analogous to immunological tolerance, which can be produced by prior treatment with the antigen. The findings prowide support for an analogy between mechanisms of adaptive enzyme synthesis and those involved in adaptive immunity.
D004361:Drug Tolerance; D004791:Enzyme Inhibitors; D007108:Immune Tolerance; D007109:Immunity; D008099:Liver; D008660:Metabolism; D010105:Oxygenases; D051381:Rats; D012106:Research; D014364:Tryptophan; D014366:Tryptophan Oxygenase
D004791:Enzyme Inhibitors; D014364:Tryptophan; D010105:Oxygenases; D014366:Tryptophan Oxygenase
ENZYME INHIBITORS; EXPERIMENTAL LAB STUDY; IMMUNE TOLERANCE; IMMUNITY; METABOLISM; OXYGENASES; RATS; TRYPTOPHAN; TRYPTOPHAN OXYGENASE