EFFECT OF MANGANESE ON CALCIFICATION OF BONE.
1. Young mice were maintained on a basal diet composed of meat, which is poor in both manganese and calcium. 2. The addition of small amounts (2.5-5.0mg./kg. of meat) of manganese improved weight gain and calcification of bone and decreased incorporation of injected radiocalcium into bone. 3. Prolonged treatment with larger amounts (10.0-25.0mg./kg. of meat) of manganese depressed growth, induced defective calcification of bone and increased incorporation of radiocalcium into bone.
D000818:Animals; D001835:Body Weight; D001842:Bone and Bones; D002113:Calcification, Physiologic; D002114:Calcinosis; D002118:Calcium / Q000378:metabolism*; D004032:Diet; D005269:Femur; D008345:Manganese; D008460:Meat; D051379:Mice; D010600:Pharmacology; D012106:Research
D008345:Manganese; D002118:Calcium
BODY WEIGHT; CALCIFICATION, PHYSIOLOGIC; CALCIUM METABOLISM; DIET; EXPERIMENTAL LAB STUDY; FEMUR; MANGANESE; MEAT; MICE; PHARMACOLOGY