THE SIGNIFICANCE OF REGIONAL LUMPH NODE METASTASES IN BREAST CARCINOMA.
The significance traditionally attached to regional lymph node metastases has been questioned following a retrospective review of 922 patients with early breast cancer.Conservative surgical removal of axillary lymph node metastases and conservative irradiation of internal mammary lymph node metastases did not prejudice the five- and 10-year survival rates of patients so treated.Axillary lymph node recurrences had an ominous prognosis and occurred more commonly in the conservatively treated patients, yet survival rates were the same as those following radical mastectomy. Many axillary lymph node recurrences occurred more than five years after primary therapy, or with or after other evidence of reactivation of the breast cancer.It is suggested that breast cancer patients do not do poorly because they have regional lymph node metastases, but rather they have these metastases when they do poorly.
D001365:Axilla; D001706:Biopsy; D001943:Breast Neoplasms; D002277:Carcinoma; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D008408:Mastectomy; D015409:Mastectomy, Radical; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate
BREAST NEOPLASMS; LYMPH NODE EXCISION; LYMPHATIC METASTASIS; MASTECTOMY; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS