TETRACYCLINE: EFFECT ON OSTEOGENESIS IN VITRO.
Tetracycline hydrochloride added to cultures of rudiments of embryonic bone in a concentration of 1 microgram per milliliter prevents mineralization of the bones and is found throughout the calcified zones. The inhibition is reversible; upon transfer of a treated culture to a normal medium, mineralization proceeds normally but maldeveloped bones result.
D000818:Animals; D001846:Bone Development; D001842:Bone and Bones; D002113:Calcification, Physiologic; D004626:Embryology; D005453:Fluorescence; D066298:In Vitro Techniques; D051379:Mice; D010012:Osteogenesis; D010600:Pharmacology; D010784:Photomicrography; D012106:Research; D013752:Tetracycline; D014116:Toxicology
D013752:Tetracycline
BONE DEVELOPMENT; CALCIFICATION, PHYSIOLOGIC; EMBRYOLOGY; EXPERIMENTAL LAB STUDY; FLUORESCENCE; MICE; PHARMACOLOGY; PHOTOMICROGRAPHY; TETRACYCLINE; TOXICOLOGIC REPORT