IN VITRO AND IN VIVO LABORATORY EVALUATION OF CEPHALOGLYCIN AND CEPHALORIDINE.
Two new antibiotics, structurally related to cephalothin, have been given the generic names cephaloglycin and cephaloridine. Cephaloglycin is the dipolar ion of 7-(d-alpha-aminophenylacetamido)-cephalosporanic acid. Cephaloridine is 7-[alpha-(2-thiophene)acetamido]-3-(1-pyridylmethyl)-3-cephem-4-carboxylic acid betaine. These new compounds were evaluated simultaneously. The broad spectrum of activity observed in vitro and in vivo with both antibiotics, the good oral absorption obtained with cephaloglycin, and the stability of cephaloridine are emphasized. The data suggest that both antibiotics merit clinical trial in humans.
D000421:Alcaligenes; D000900:Anti-Bacterial Agents; D001412:Bacillus subtilis; D001774:Blood Chemical Analysis; D002507:Cephaloglycin; D002509:Cephaloridine; D002512:Cephalothin; D055598:Chemical Phenomena; D002621:Chemistry; D002845:Chromatography; D003017:Clostridium tetani; D003353:Corynebacterium diphtheriae; D004351:Drug Resistance; D004352:Drug Resistance, Microbial; D004754:Enterobacter; D004755:Enterobacteriaceae; D004926:Escherichia coli; D006190:Haemophilus; D066298:In Vitro Techniques; D007709:Klebsiella; D051379:Mice; D009344:Neisseria gonorrhoeae; D009345:Neisseria meningitidis; D010600:Pharmacology; D011511:Proteus; D011549:Pseudomonas; D011550:Pseudomonas aeruginosa; D012106:Research; D012475:Salmonella; D012760:Shigella; D013210:Staphylococcus; D013291:Streptococcus; D013296:Streptococcus pneumoniae; D014116:Toxicology
D000900:Anti-Bacterial Agents; D002509:Cephaloridine; D002507:Cephaloglycin; D002512:Cephalothin
AEROBACTER; ALCALIGENES; ANTIBIOTICS; BACILLUS SUBTILIS; BLOOD CHEMICAL ANALYSIS; CEPHALOTHIN; CHEMISTRY; CHROMATOGRAPHY; CLOSTRIDIUM TETANI; CORYNEBACTERIUM DIPHTHERIAE; DIPLOCOCCUS PNEUMONIAE; DRUG RESISTANCE, MICROBIAL; ESCHERICHIA COLI; EXPERIMENTAL LAB STUDY; HAEMOPHILUS; KLEBSIELLA; MICE; NEISSERIA GONORRHOEAE; NEISSERIA MENINGITIDIS; PARACOLOBACTRUM; PHARMACOLOGY; PROTEUS; PSEUDOMONAS; SALMONELLA; SHIGELLA; STAPHYLOCOCCUS; STREPTOCOCCUS; TOXICOLOGIC REPORT