ELECTROPHORESIS STUDY OF EXTRACTS OF SUBMAXILLARY SALIVARY GLANDS FROM NATURALLY RABID DOGS.
Rabies virus in submaxillary salivary glands from naturally infected dogs was investigated by a paper electrophoresis technique, and the virus activity was quantitated by intracerebral titration in mice. Extracts from these salivary glands were found to contain (a) 10(4) to 10(6) mouse ICLD (50) units of wild rabies seed and (b) a protein complex that migrated electrophoretically in the albumin band and more conspicuously in the beta and gamma bands of normal horse serum. The protein complex was interpreted to comprise aggregates of neutralizing antirabies antibody.
D000818:Animals; D004283:Dog Diseases; D004285:Dogs; D004586:Electrophoresis; D006736:Horses; D007120:Immunochemistry; D007122:Immunoelectrophoresis; D051379:Mice; D009500:Neutralization Tests; D011818:Rabies; D011819:Rabies Vaccines; D011820:Rabies virus; D012469:Salivary Glands; D013363:Submandibular Gland
D011819:Rabies Vaccines
DOG DISEASES; HORSES; IMMUNOCHEMISTRY; IMMUNOELECTROPHORESIS; MICE; NEUTRALIZATION TESTS; RABIES; RABIES VIRUS; SALIVARY GLANDS; SUBMANDIBULAR GLAND