ABNORMAL IMMUNE MECHANISM IN ALLOGENEIC RADIATION CHIMERAS.
Mice were subjected to x-rays (950 roentgens) and injected with isogeneic (isologous) or allogeneic (homnologous) bone marrow. Six to 8 months later these chimeras were injected with Salmonella typhi flagellar antigen, and the formation of antibodies resistant and sensitive to destruction by treatment in vitro with 2-mercaptoethanol was determined. The allogeneic chimeras showed almost normal amounts of serumn antibody after a third injection of antigen but a relative defect in their ability to synthesize antibody resistant to 2-mercaptoethanol. Apparently control of antibody formation becomes abnormal in the presence of the immunologic tolerance existing between the host and the foreign hematopoietic graft.
D000818:Animals; D000906:Antibodies; D000917:Antibody Formation; D000941:Antigens; D001853:Bone Marrow; D016026:Bone Marrow Transplantation; D002678:Chimera; D007108:Immune Tolerance; D008623:Mercaptoethanol; D051379:Mice; D010600:Pharmacology; D011828:Radiation Chimera; D011831:Radiation Genetics; D012106:Research; D012485:Salmonella typhi; D013438:Sulfhydryl Compounds; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D000906:Antibodies; D000941:Antigens; D013438:Sulfhydryl Compounds; D008623:Mercaptoethanol
ANTIBODY FORMATION; ANTIGENS; BONE MARROW TRANSPLANTATION; EXPERIMENTAL LAB STUDY; IMMUNE TOLERANCE; MERCAPTOETHANOL; MICE; PHARMACOLOGY; RADIATION GENETICS; SALMONELLA TYPHOSA; SULFHYDRYL COMPOUNDS; TRANSPLANTATION IMMUNOLOGY; TRANSPLANTATION, HOMOLOGOUS