A study of possible mediators of inflammatory reactions in the mouse foot.
A number of compounds have been studied for their ability to antagonize the inflammatory reaction produced by injections of formaldehyde and 5-hydroxytryptamine in the mouse foot. An attempt has been made to elucidate the ways in which certain hydroxybenzoates, pyrazolones, sympathomimetic amines, flavone and flavanone glycosides, local anaesthetics, antihistamines and anti-5-hydroxytryptamine substances produce their anti-inflammatory effect.
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D018926:Anti-Allergic Agents; D001565:Benzoates / Q000494:pharmacology*; D047309:Flavones / Q000494:pharmacology*; D005557:Formaldehyde / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007249:Inflammation; D051379:Mice; D012701:Serotonin / Q000494:pharmacology*; D013566:Sympathomimetics / Q000494:pharmacology*
D000779:Anesthetics, Local; D018926:Anti-Allergic Agents; D001565:Benzoates; D047309:Flavones; D006571:Heterocyclic Compounds; D006634:Histamine H1 Antagonists; D013566:Sympathomimetics; D005557:Formaldehyde; D012701:Serotonin; C043562:flavone
ANESTHETICS, LOCAL/pharmacology; ANTIHISTAMINICS/pharmacology; BENZOATES/pharmacology; FLAVONES/pharmacology; FORMALDEHYDE/pharmacology; HETEROCYCLIC COMPOUNDS/pharmacology; INFLAMMATION/experimental; SEROTONIN/pharmacology; SYMPATHOMIMETICS/pharmacology