Myo-inositol in the biosynthesis of streptomycin by Streptomyces griseus.
When myo-inositol is present in a growing culture of Streptomyces griseus the yield of streptomycin is increased, and the amount of carbon-14-from uniformly labeled glucose-incorporated into the streptidine and streptobiosamine moieties of streptomycin is lowered by 41 percent and 21.7 percent, respectively. These results present strong indirect evidence for the participation of myo-inositol or its metabolic products in streptidine biosynthesis.
D002250:Carbon Radioisotopes; D005947:Glucose; D006146:Guanidines; D006595:Hexosamines; D007294:Inositol / Q000494:pharmacology*; D013302:Streptomyces / Q000378:metabolism*; D013305:Streptomyces griseus; D013307:Streptomycin / Q000378:metabolism*
D002250:Carbon Radioisotopes; D006146:Guanidines; D006595:Hexosamines; D007294:Inositol; C005733:streptidine; D005947:Glucose; D013307:Streptomycin
INOSITOL/pharmacology; STREPTOMYCES/metabolism; STREPTOMYCIN/metabolism