Toxicity of blood clotting factors.
Pure bovine thrombin was separated from autoprothrombin C, and the lethal intravenous dose for mice weighing 25 g was 0.4 ml of a solution containing 50 units of thrombin per milliliter. Autoprothrombin C was not toxic alone, but with crude cephalin it was fatal. The clotting time of human plasma was only slightly accelerated by autoprothrombin C alone; the clotting time was as short as 5 seconds with a combination of autoprothrombin C and cephalin.
D000818:Animals; D001777:Blood Coagulation; D001779:Blood Coagulation Factors; D002417:Cattle; D006801:Humans; D051379:Mice; D011516:Prothrombin / Q000633:toxicity*; D013917:Thrombin / Q000633:toxicity*
D001779:Blood Coagulation Factors; D011516:Prothrombin; D013917:Thrombin
PROTHROMBIN/toxicology; THROMBIN/toxicology