Drug resistance due to inbreeding.
Inbred mice susceptible to audiogenic seizures were found to develop resistance to the protective effects of chlorpromazine and its analogs. It is proposed that the use of such inbred mice provides a unique new tool for studying drug mechanism and drug resistance.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D004351:Drug Resistance; D005823:Genetics; D007178:Inbreeding; D051379:Mice; D012640:Seizures; D014149:Tranquilizing Agents / Q000494:pharmacology*
D014149:Tranquilizing Agents; D002746:Chlorpromazine
CHLORPROMAZINE/pharmacology; CONVULSIONS/experimental; GENETICS; TRANQUILIZING AGENTS/pharmacology