Mixturs of quaternary ammonium compounds and long-chain fatty acids as antifungal agents.
The influence of undecylenic acid on the fungistatic effect of phenoxyethyldimethyldodecylammonium bromide (Domiphen bromide) against Trichophyton mentagrophytes was investigated. The unsaturated fatty acid was found to enhance the fungistatic activity of Domiphen bromide against this organism. The ratio of concentrations of these agents has a marked influence on the results of in vitro tests for antifungal action resulting in a completely different effect than heretofore noted in combination experiments against bacteria. The enhancing phenomenon is not particular to T. mentagrophytes, it was observed also with Candida albicans.
D064751:Ammonium Compounds; D000891:Anti-Infective Agents, Local; D000935:Antifungal Agents; D001419:Bacteria; D002176:Candida albicans; D003879:Dermatologic Agents; D005227:Fatty Acids / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated; D005658:Fungi / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D014249:Trichophyton
D064751:Ammonium Compounds; D000891:Anti-Infective Agents, Local; D000935:Antifungal Agents; D003879:Dermatologic Agents; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D000644:Quaternary Ammonium Compounds; C007556:domiphen
ANTISEPTICS, QUATERNARY AMMONIUM/pharmacology; FATTY ACIDS/pharmacology; FUNGI/pharmacology