Common human viruses as carcinogen vectors.
Single doses of pairs of viruses and organic carcinogens (in amounts too small in themselves to induce tumors) were administered to male Swiss mice free of polyoma virus. Malignant tumors developed in groups of mice injected with five of the carcinogen-virus pairs. Prior immunization against the virus of a pair prevented tumor formation by that pair. Carcinogen binding by poliovirus 2 was demonstrated in vitro.
D000818:Animals; D002273:Carcinogens; D005822:Genetic Vectors; D006801:Humans; D007114:Immunization; D008297:Male; D051379:Mice; D014780:Viruses
D002273:Carcinogens
CARCINOGENS; VIRUSES