Studies on the biosynthesis of streptomycin.
Myo-inositol, especially in combination with arginine, enhances streptomycin production. Compounds which show structural relationship with myo-inositol are ineffective.Myo-inositol decreases the incorporation of C(14)-glucose into streptomycin, particularly into streptidine. This effect suggests that myo-inositol is a precursor of the streptidine ring. Methionine stimulates antibiotic production in a synthetic medium but proves to be unfavorable in a complex medium. The gamma- and delta-isomers of hexachlorocyclohexane inhibit streptomycin formation. The formation of streptomycin by washed mycelium was studied. Essentially the same results were here obtained as with growing cultures.
D000900:Anti-Bacterial Agents; D005947:Glucose; D006146:Guanidines; D006595:Hexosamines; D007294:Inositol; D012106:Research; D013307:Streptomycin / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D006146:Guanidines; D006595:Hexosamines; D007294:Inositol; C005733:streptidine; D005947:Glucose; D013307:Streptomycin
STREPTOMYCIN/metabolism