Urinary excretion of amines in phenylketonuria and mongolism.
Children with phenylketonuria excrete considerably less serotonin and tryptamine and somewhat less normetanephrine and p-tyramine than normal children. The excretion of these amines was not decreased in mongolism. Even during monoamine oxidase blockade, o-tyramine could not be detected in the urine of phenylketonurics. These findings are discussed in relation to the mental defect of phenylketonuria.
D000588:Amines / Q000652:urine*; D002648:Child; D004314:Down Syndrome / Q000652:urine*; D006801:Humans; D010661:Phenylketonurias / Q000652:urine*; D012701:Serotonin; D014363:Tryptamines
D000588:Amines; D014363:Tryptamines; D012701:Serotonin; C030820:tryptamine
AMINES/urine; MONGOLISM/urine; PHENYLPYRUVIC OLIGOPHRENIA/urine