Synthetic oxytocin as an antagonist of experimental cardiac anoxic changes in rabbits.
Synthetic oxytocin (Syntocinon) can be shown to reduce or abolish ST-T changes induced experimentally by hypoxaemia alone, by hypoxaemia and ergometrine, by vasopressin, and by a new procedure involving injection of small doses of picrotoxin into the lateral cerebral ventricle. Ventricular fibrillation induced by picrotoxin can also be reversed by oxytocin. These effects suggest a probable metabolic action of oxytocin against cardiac anoxic changes, and its possible therapeutic usefulness as an antagonist of myocardial ischaemia. It is speculated that this might be a physiological action of the hormone.
D000818:Animals; D001127:Arginine Vasopressin; D004562:Electrocardiography / Q000494:pharmacology*; D004874:Ergonovine; D000860:Hypoxia; D017202:Myocardial Ischemia; D010120:Oxytocics / Q000494:pharmacology*; D010121:Oxytocin; D011817:Rabbits; D014667:Vasopressins
D010120:Oxytocics; D014667:Vasopressins; D001127:Arginine Vasopressin; D010121:Oxytocin; D004874:Ergonovine
ANOXIA/experimental; ELECTROCARDIOGRAPHY/pharmacology; OXYTOCICS/pharmacology