title: [Association of deletions of the RET proto-oncogene wtih aggressive course of sporatic C-cell carcinoma].
abstract: A growing number of reports describing the association of certain deletions within exon 11 of the RET proto-oncogene with aggressive courses of medullary thyroid carcinoma, point to a potential prognostic relevance of molecular features in the sporadic tumor, analogous to the hereditary variant.
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics; D020029:Base Pairing / Q000235:genetics; D018276:Carcinoma, Medullary / Q000235:genetics* / Q000473:pathology; D002872:Chromosome Deletion; D003062:Codon; D004252:DNA Mutational Analysis; D005091:Exons; D006801:Humans; D009361:Neoplasm Invasiveness / Q000235:genetics; D018807:Polymorphism, Single-Stranded Conformational; D011379:Prognosis; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D003062:Codon; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases