title: [Cholestatic icterus during parenteral nutrition and the therapeutic effect of enteral feeding--case report].
abstract: An acute operation was made on a 56-year woman for inflammatory perforation of colon. A series of repeated operations followed due to relapsing iatrogenic intestinal fistula and peritonitis. From the day 70 the patient was treated at the Intensive Metabolic Care Unit of the Gerontological and Metabolic Clinic of Faculty Hospital in Hradec Králové. Having cured the septic shock the authors prepared the patient to a reconstruction operation on alimentary tract by administering parenteral nutrition, treating the wounds and by motion rehabilitation. From day 150 on the patient was treated with low doses of enteral nutrition into the segment of intestine between the fistulas, in connection with the subsequent decrease of two-month lasting hyperbilirubinemia of 200-260 mumol/l. A successful reconstruction of the alimentary tract was performed on the day 205 of the treatment with the time lapse of 146 days after the last surgical intervention. A three-fold anastomosis on small intestine and a resection of the fistula on the transversal colon was made. The post-operation fistula was healed-up conservatively, while the parenteral nutrition continued, as verified on day 246 by enteroclysis. The paper draws attention to the importance of conservative metabolic care in the therapy of dishiscences of intestinal anastomoses not treated by acute surgery in time. A favourable additive effect of enteral nutrition on the persisting cholestasis during parenteral nutrition is discussed.
mesh_terms: D002779:Cholestasis / Q000209:etiology* / Q000628:therapy; D004750:Enteral Nutrition; D005260:Female; D006801:Humans; D007412:Intestinal Fistula / Q000209:etiology / Q000628:therapy; D007416:Intestinal Perforation / Q000601:surgery; D007565:Jaundice / Q000209:etiology; D008875:Middle Aged; D010288:Parenteral Nutrition / Q000009:adverse effects*; D010538:Peritonitis / Q000209:etiology / Q000628:therapy; D011183:Postoperative Complications; D013529:Surgical Wound Dehiscence