title: Safety of a modified-live combination vaccine against respiratory and reproductive diseases in pregnant cows.
abstract: A combination vaccine (Bovi-Shield FP4 + L5, Pfizer Animal Health) containing modified-live virus (MLV) components against bovine herpesvirus-1 (BHV-1), bovine viral diarrhea virus BVDV), parainfluenza virus-3 (PI3), bovine respiratory syncytial virus (BRSV), and inactivated cultures of Leptospira canicola, grippotyphosa, hardjo, icterohaemorrhagiae, and pomona was evaluated for safety in pregnant beef and dairy animals. Heifers vaccinated prebreeding with the minimum immunizing dose (lowest antigen level initiating immunizing effects) of the vaccine's MLV BHV-1 or BVDV components and during pregnancy (approximately 200 days of gestation) with vaccine containing 10x doses of the same BHV-1 and BVDV components delivered live, healthy calves that were determined to be serologically negative (titer less than 1:2) for neutralizing antibodies to BHV-1 and BVDV prior to nursing. Additionally, in three field safety studies, previously vaccinated cows and heifers that received a field dose (vaccine containing antigen levels required for commercial sale of the MLV combination vaccine during either the first, second, or third trimester of pregnancy had abortion rates similar to those of pregnant cows and heifers vaccinated during the same stage of pregnancy with sterile water diluent.
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D001908:Diarrhea Viruses, Bovine Viral / Q000276:immunology; D005260:Female; D007242:Herpesvirus 1, Bovine / Q000276:immunology; D007273:Injections, Intramuscular / Q000662:veterinary; D010224:Parainfluenza Virus 3, Human / Q000276:immunology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control / Q000662:veterinary*; D011264:Pregnancy Trimesters; D011270:Pregnancy, Animal / Q000276:immunology; D012136:Respiratory Syncytial Viruses / Q000276:immunology; D014611:Vaccination / Q000662:veterinary; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000009:adverse effects*; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D017778:Vaccines, Combined; D014765:Viral Vaccines