title: The developmental pattern of c-fos expression in the rat thalamus following open-field stress stimulation.
abstract: The thalamic nuclei with their defined set of input-output connections are the primary channel for information flow to the cerebral cortex. Several data suggest that neurons of that area are involved in the response to various aversive stimulations. However the pattern of activation seems to depend on the stress model as well as the stage of maturation. In the present study we would like to check which nuclei of the thalamus show expression of c-fos in the response to the "open field test", and how this response pattern changes during the maturation process. 30 rats of age ranged from P0 to P120 (P-postnatal day) were studied. The experimental group was exposed to the "open field test" for 10 minutes. After perfusion and fixation, brains were cut and stained for c-fos with immunohistochemical method. Our results showed that during development the pattern of c-fos activity in the thalamic nuclei after stress stimulation undergoes significant changes. Distinct c-fos expression was observed in the paraventricular nucleus, intergeniculate leaflet and ventral lateral geniculate nucleus. These findings suggest that these nuclei may play a direct role in the stress reaction involved in the response to the "open field test".
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats / Q000254:growth & development* / Q000378:metabolism*; D017208:Rats, Wistar / Q000254:growth & development / Q000378:metabolism; D013312:Stress, Physiological; D013788:Thalamus / Q000254:growth & development* / Q000378:metabolism*
chemical_list: D016760:Proto-Oncogene Proteins c-fos