Possible correlation between abilities of a variety of polyamines to increase activator protein-1 DNA binding and to inhibit [3H]spermidine transport in nuclear fractions of murine brain.
The addition of a number of natural and synthetic polyamines significantly increased activator protein (AP1) DNA binding in nuclear extracts of murine whole brain, which occurred in a manner positively correlated with their potencies to inhibit temperature-dependent transport of [3H]spermidine in brain nuclear fractions. These results suggest that polyamines may affect gene transcription by AP1 complex after incorporation into the nucleus in rodent brain.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D008297:Male; D051379:Mice; D011073:Polyamines / Q000378:metabolism* / Q000494:pharmacology; D013095:Spermidine / Q000378:metabolism*; D018808:Transcription Factor AP-1 / Q000187:drug effects / Q000378:metabolism*; D014316:Tritium
D011073:Polyamines; D018808:Transcription Factor AP-1; D014316:Tritium; D004247:DNA; D013095:Spermidine