Highly regio- and enantioselective Heck reaction of N-methoxycarbonyl-2-pyrroline with planar chiral diphosphine-oxazoline ferrocenyl ligands.
[reaction: see text] A series of planar chiral diphosphine-oxazoline ferrocene ligands were effectively applied in the asymmetric arylation of N-methoxycarbonyl-2-pyrroline, and up to 99% ee was observed for the product 3. The regioselectivity of this reaction was strongly affected by the different precursors of the palladium species and the polarity of the solvent.
D005296:Ferrous Compounds / Q000737:chemistry*; D008024:Ligands; D000075163:Metallocenes; D010080:Oxazoles / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D010720:Phosphines / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
D005296:Ferrous Compounds; D008024:Ligands; D000075163:Metallocenes; D010080:Oxazoles; D010720:Phosphines; D011758:Pyrroles; C013231:pyrroline; D010165:Palladium; C004998:ferrocene