Synthesis and in vitro analysis of atrial natriuretic peptide-albumin conjugates.
Atrial natriuretic peptide (ANP) is a clinically useful anti-hypertensive hormone. Maleimide derivatives of ANP have been synthesized and conjugated to cysteine-34 of human serum albumin. The conjugates were analyzed to assess their stability, receptor binding affinity and ability to stimulate guanylyl-cyclase activity in rat lung fibroblasts.
D000418:Albumins / Q000138:chemical synthesis / Q000737:chemistry*; D000595:Amino Acid Sequence; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D008969:Molecular Sequence Data; D051381:Rats
D000418:Albumins; D009320:Atrial Natriuretic Factor