title: Geraniol-derived 1,2,4-trioxanes with potent in-vivo antimalarial activity.
abstract: Geraniol, an abundantly available naturally occurring allylic alcohol, has been used as a starting material to prepare a series of 6-[alpha-(3'-aryl-3'-hydroxypropyl)vinyl]-1,2,4-trioxanes. Some of these novel trioxanes have shown very promising antimalarial activity against multi-drug resistant Plasmodium yoelii in mice by both intramuscular (im) and oral routes.
mesh_terms: D000080462:Acyclic Monoterpenes; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology; D051379:Mice; D010967:Plasmodium yoelii / Q000187:drug effects; D013729:Terpenes / Q000737:chemistry*
chemical_list: D000080462:Acyclic Monoterpenes; D000962:Antimalarials; D013729:Terpenes; C007836:geraniol