The evaluation of lipid peroxidation and acute effect of octreotide on lipid peroxidation in patients with active acromegaly.
BACKGROUND
Although lipid peroxidation has been suggested to play a role in the etiology of many diseases, there is no report about its role in acromegaly in the literature. In the present study, we analyzed the basal levels of lipid peroxides (LPO) in newly diagnosed acromegalic patients, and to evaluate whether octreotide (OCT) has any effect on lipid peroxidation in these patients.


METHODS
Plasma lipid peroxide levels before and after acute OCT administration were measured in 12 newly diagnosed acromegalic patients. Blood samples were drawn at basal and 4, 8, and 24 h after octreotide injection (100 microg s.c.). Plasma concentrations of lipid peroxides were estimated from measurement of thiobarbituric acid reactive substance (TBARS), using 1,1,3,3-tetra-ethoxypropane as a standard.


RESULTS
This study shows that acromegalic patients have significantly higher basal plasma lipid peroxides levels compared to hours after OCT injection (p<0.001). Although a significant decrease was observed after 8 and 24 h in comparison to basal level (p<0.001), the lipid peroxide levels tended to increase at 24 h though still low when compared to basal level.


CONCLUSIONS
Acromegalic patients have high basal lipid peroxide levels, which was significantly decreased after OCT administration.
D000172:Acromegaly / Q000188:drug therapy / Q000378:metabolism*; D000328:Adult; D016022:Case-Control Studies; D005069:Evaluation Studies as Topic; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D013997:Time Factors
D008054:Lipid Peroxides; D017392:Thiobarbituric Acid Reactive Substances; D005978:Glutathione; D015282:Octreotide