Photochemistry of bromouracil containing Z-DNA.
To investigate the mechanism underlying the photoreaction of bromouracil in DNA, a detailed analysis of photoirradiated 5'-d(CGCG(Br)UGCG)-3'/5'-d(C(8MeO)GCAC(m)GCG)-3' was undertaken. We found that rG- and 2-aminoimidazolone-containing octanucleotides are formed efficiently in Z-form DNA. These results suggest that interstrand electron transfer initiates the photoreaction of bromouracil in Z-DNA.
D001483:Base Sequence; D001976:Bromouracil / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D010777:Photochemistry
D001976:Bromouracil; D004247:DNA