Neurodevelopmental follow-up of children of women infected with varicella during pregnancy: a prospective study.
BACKGROUND
The fetal varicella syndrome is associated with abnormal central nervous system development, which in many cases is associated with mental retardation. However, the incidence of neurobehavioral deficits in asymptomatic structurally normal children whose mothers had clinically diagnosed varicella-zoster virus infection is unknown.


METHODS
Neurobehavioral outcome was evaluated in 84 children born to women infected with varicella during pregnancy and 40 children born to women who were not infected with varicella during pregnancy. Children were 3 to 15 years of age at the time of testing. Clinical features of the fetal varicella syndrome were present in only 1 of the 84 children in the varicella group. These sample sizes provide statistical power of 0.80 (alpha = 0.05) to detect group differences of 0.54 sd (the equivalent of 8.1 IQ points).


RESULTS
No differences were found in the test performance of the two groups. In addition, within the varicella sample, no meaningful differences were found relative to infection-related hyperthermia or the timing of infection.


CONCLUSIONS
As a group, the children born to women infected with varicella-zoster virus during pregnancy and who do not have structural features characteristic of the fetal varicella syndrome are not neurodevelopmentally different from unexposed, uninfected control children.
D000293:Adolescent; D000704:Analysis of Variance; D016022:Case-Control Studies; D002644:Chickenpox / Q000175:diagnosis / Q000635:transmission*; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology; D002658:Developmental Disabilities / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D018445:Infectious Disease Transmission, Vertical; D015999:Multivariate Analysis; D009422:Nervous System Diseases / Q000453:epidemiology* / Q000209:etiology; D009483:Neuropsychological Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis*; D011336:Probability; D011446:Prospective Studies; D018570:Risk Assessment