Synthesis and properties of oligonucleotides containing C-2 and/or C-5 substituted arabinofuranosyluracils.
The oligodeoxyribonucleotides (ODN) containing C-2 and/or C-5 substituted arabinofuranosyluracils were synthesized by a post-synthetic modification method. The duplex stability of the ODN bearing isocytosine derivative with DNA was lower than that of the normal ODN/DNA duplex but the ODN bearing C5-substituted uracil derivative was similar to the normal ODN/DNA duplex.
D001086:Arabinofuranosyluracil / Q000737:chemistry*; D001483:Base Sequence; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D009841:Oligonucleotides; D001086:Arabinofuranosyluracil