title: Progressive myoclonus in a child with a deep cerebellar mass.
abstract: Myoclonus is often associated with pathology of the cerebellum. However, the site of neurons responsible for the generation of myoclonus in cerebellar disease is not known. The authors report a young child with myoclonus associated with a ganglioglioma in the region of the deep cerebellar white matter and cerebellar nuclei. They hypothesize that abnormal paroxysmal discharge of neurons in the cerebellar nuclei can generate myoclonus.
mesh_terms: D002524:Cerebellar Ataxia / Q000209:etiology; D002528:Cerebellar Neoplasms / Q000150:complications* / Q000601:surgery; D002529:Cerebellar Nuclei / Q000503:physiopathology; D018450:Disease Progression; D004401:Dysarthria / Q000209:etiology; D018303:Ganglioglioma / Q000150:complications* / Q000601:surgery; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009207:Myoclonus / Q000209:etiology* / Q000503:physiopathology; D011183:Postoperative Complications