[Comparative histomorphometric studies of shin bones of male and female rats following tail suspension].
In a 30-d experiment with tail-suspension of male and female rats histomorphometric studies were performed to compare impacts of deficient weight loading on the tibial spongy tissue. The 30-d suspension was found to slow down the body and adrenal mass gain irrespective of sex; however, this effect was more pronounced in male rats suggesting a greater stress to males as compared to females. Also, suspension caused tibial osteopenia in either of sexes. Decreases in the tibial spongy mass in suspended male and female rats were similar to control. At the same time, inhibition of the longitudinal bone growth attested by diminished height of the cartilaginous growth plate was more noticeable in males as compared with females. We attribute this observation to the reduction in testosterone production and a more violent stress reaction.
D000311:Adrenal Glands / Q000254:growth & development; D000818:Animals; D001851:Bone Diseases, Metabolic / Q000209:etiology* / Q000473:pathology; D005260:Female; D019417:Hindlimb Suspension; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D013312:Stress, Physiological / Q000150:complications; D013739:Testosterone / Q000378:metabolism; D013950:Thymus Gland / Q000254:growth & development; D013977:Tibia / Q000254:growth & development / Q000473:pathology*; D013997:Time Factors; D014893:Weightlessness / Q000009:adverse effects*
D013739:Testosterone