title: Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase.
abstract: Carbocyclic and acyclic nucleosides possessing 2-fluoroadenine, such as 2-fluoronoraristeromycin (6) and 2-fluoro-9-[(2S,3R)-2,3,4-trihydroxy-butyl-1-yl]adenine (8), were synthesized and their inhibitory activities against human and Plasmodium falciparum recombinant SAH hydrolase were investigated.
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry*; D043383:Adenosylhomocysteinase; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006867:Hydrolases / Q000037:antagonists & inhibitors*; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000201:enzymology*; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors
chemical_list: D000962:Antimalarials; D004791:Enzyme Inhibitors; D009705:Nucleosides; D011994:Recombinant Proteins; C038208:2-fluoroadenine; D006867:Hydrolases; D043383:Adenosylhomocysteinase; D000225:Adenine