title: Metoclopramide protection of cholinesterase from paraoxon inhibition.
abstract: This study evaluated the protective effect of the benzamide compound metoclopramide (MCP) against inhibition by paraoxon (POX) as assessed by red blood cell acetylcholinesterase (RBC-AChE) activity. Three groups of 6 rats each were used. All substances were applied ip daily for 5 d, followed by a 2-d rest. The 7-d cycle was repeated 6 times. Group 1 received 100 nM POX, Group 2 received 50 microM MCP. Group 3 received 100 nM POX + 50 microM MCP. Red blood cell acetylcholinesterase measurements were performed at base line and then after each 7-d cycle. Enzyme activities were compared using the Mann-Whitney rank order test. Metoclopramide conferred significant in vivo protection from inhibition of RBC-AChE by POX.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D010261:Paraoxon / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats
chemical_list: D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D000110:Acetylcholinesterase; D008787:Metoclopramide; D010261:Paraoxon