Bispecific antibodies for polyclonal T-cell engagement.
Single-chain bispecific antibodies are emerging as an extremely powerful and promising class of polyclonal T-cell-engaging proteins with hitherto unknown properties. Such bispecific antibodies have the potential to bypass most T-cell escape mechanisms selected in tumor cells during their development into solid tumors and metastases. With cytotoxic T-cells, bispecific antibodies can recruit the most potent effector cells for tumor cell elimination. Studying the mechanism of action of newly developed single-chain bispecific antibodies could provide insight into the shortcomings of bispecific antibodies that have been studied previously.
D000818:Animals; D018033:Antibodies, Bispecific / Q000008:administration & dosage / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use*; D002999:Clone Cells; D006801:Humans; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*
D018033:Antibodies, Bispecific