title: Synthesis of novel C2 and C2-C8 linked pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide hybrids as DNA-binding agents.
abstract: Synthesis of C2 and C2-C8 linked pyrrolobenzodiazepine-naphthalimide hybrids have been prepared that exhibit significant DNA-binding affinity and cytotoxicity.
mesh_terms: D001569:Benzodiazepines / Q000737:chemistry* / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D007094:Imides / Q000737:chemistry* / Q000378:metabolism; D009281:Naphthalenes / Q000737:chemistry* / Q000378:metabolism; D011758:Pyrroles / Q000737:chemistry* / Q000378:metabolism
chemical_list: D007094:Imides; D009281:Naphthalenes; D011758:Pyrroles; C438462:pyrrolo(2,1-c)(1,4)benzodiazepine; D001569:Benzodiazepines; D004247:DNA