title: Dedifferentiated malignant myoepithelioma of the parotid gland.
abstract: Dedifferentiated salivary gland tumor is a rare, recently recognized tumor type. A case of dedifferentiated malignant myoepithelioma in a 59-year-old man who presented with a painful mass in the left preauricular region is reported. Histologically, two distinct neoplastic cell populations were observed in the same tumor mass. The first population was composed of solid nests of polygonal eosinophilic or glycogen-rich clear cells showing neoplastic myoepithelial immunocytological features, such as positivity for cytokeratins, vimentin, S-100 protein (S-100), alpha-smooth muscle actin (SMA) and glial fibrillary acidic protein (GFAP). A multinodular growth pattern, necrosis and occasional mitotic figures suggested malignancy. This population was diagnosed as low-grade malignant myoepithelioma. The second population infiltrated diffusely into the parotid gland and facial nerves. It consisted of polygonal or short spindle cells with obvious pleomorphism and atypical mitoses. The tumor cells were positive for vimentin and cytokeratins, and showed an accumulation of p53 and cyclin D1. S-100 protein, SMA and GFAP were negative. This population was regarded as undifferentiated carcinoma. A final diagnosis of dedifferentiated malignant myoepithelioma was made. This seems to be the first published case of dedifferentiation in malignant myoepithelioma. Because any tumor type can undergo dedifferentiation with accumulation of additional genetic changes, complete sampling should be the standard approach to all salivary gland tumors in order to avoid missing a dedifferentiation component.
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009208:Myoepithelioma / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D009363:Neoplasm Proteins / Q000032:analysis; D009364:Neoplasm Recurrence, Local; D010306:Parotid Gland / Q000473:pathology* / Q000601:surgery; D010307:Parotid Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins