Activity of human beta-defensin 3 alone or combined with other antimicrobial agents against oral bacteria.
The in vitro activities of human beta-defensin 3 (hBD-3) alone or combined with lysozyme, metronidazole, amoxicillin, and chlorhexidine were investigated with the oral bacteria Streptococcus mutans, Streptococcus sanguinis, Streptococcus sobrinus, Lactobacillus acidophilus, Actinobacillus actinomycetemcomitans, and Porphyromonas gingivalis. hBD-3 showed bactericidal activity against all of the bacterial species tested. The bactericidal effect was enhanced when the peptide was used in combination with the antimicrobial agents mentioned above.
D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects; D000890:Anti-Infective Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004338:Drug Combinations; D006801:Humans; D007779:Lactobacillus acidophilus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000187:drug effects; D016986:Streptococcus sobrinus / Q000187:drug effects; D023083:beta-Defensins / Q000494:pharmacology*
D000890:Anti-Infective Agents; C422950:DEFB103A protein, human; D004338:Drug Combinations; D023083:beta-Defensins