Cytotoxic granule-mediated apoptosis: unraveling the complex mechanism.
The molecular details of cytotoxic granule-mediated apoptosis have been gleaned from the study of the effects of isolated granzymes and perforin on target cells. Recent evidence indicates that the physiological apoptosis-inducing form is a multi-component macro-complex consisting of cationic granule proteins non-covalently linked to the chondroitin-sulfate proteoglycan, serglycin.
D000818:Animals; D017209:Apoptosis; D011508:Chondroitin Sulfate Proteoglycans / Q000378:metabolism / Q000502:physiology; D003594:Cytoplasmic Granules / Q000378:metabolism* / Q000502:physiology; D003602:Cytotoxicity, Immunologic; D005089:Exocytosis; D053804:Granzymes; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism / Q000502:physiology; D018448:Models, Immunological; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D011509:Proteoglycans / Q000502:physiology; D012697:Serine Endopeptidases / Q000502:physiology; D015398:Signal Transduction; D013602:T-Lymphocytes, Cytotoxic / Q000378:metabolism; D033921:Vesicular Transport Proteins
D011508:Chondroitin Sulfate Proteoglycans; D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D011509:Proteoglycans; D033921:Vesicular Transport Proteins; C075430:serglycin; D054353:Perforin; C509213:GZMB protein, human; D053804:Granzymes; D012697:Serine Endopeptidases