title: tincar encodes a novel transmembrane protein expressed in the Tinman-expressing cardioblasts of Drosophila.
abstract: We cloned and characterized the Drosophila gene, tincar (tinc), which encodes a novel protein with eight putative transmembrane domains. The tinc mRNA was expressed specifically in four of the six pairs of cardioblasts in each segment, in a pattern identical to that of tinman (tin), a homeobox gene required for the specification of the dorsal vessel. In the non-Tin-expressing pairs of cardioblasts, tinc transcription seemed to be repressed by Seven-up.
mesh_terms: D000818:Animals; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics; D005801:Genes, Homeobox; D006321:Heart; D008565:Membrane Proteins / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D008565:Membrane Proteins; D012333:RNA, Messenger; D015534:Trans-Activators