Oligonucleotide duplex stabilization by end-linked terpyridine x Cu(II) complexes.
As a part of our recent studies of RNA cleavage using antisense oligonucleotide-metal complex(es) conjugates, we prepared self-complementary 2'-O-methyloligonucleotides with a terpyridine x Cu(II) complex, which was attached to the sugar portion of the 5'-end or 3'-end. The thermal stabilities of the formed duplexes, as compared with those of the unmodified 2'-O-methyl duplexes, revealed that both the 5'- and 3'-complexes greatly enhanced the duplex stability.
D001483:Base Sequence; D003300:Copper / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
D009841:Oligonucleotides; D011725:Pyridines; D003300:Copper; C023666:pyridine