Dual function of C-type lectin-like receptors in the immune system.
Carbohydrate-binding C-type lectin and lectin-like receptors play an important role in the immune system. The large family can be subdivided into subtypes according to their structural similarities and functional differences. The selectins are of major importance in mediating cell adhesion and migration, and the mannose receptor subfamily is specialised in the binding and uptake of pathogens. Recent advances show that some of the type II C-type lectin-like receptors, such as DC-SIGN, can function both as an adhesion receptor and as a phagocytic pathogen-recognition receptor, similar to the Toll-like receptors. Although major differences in the cytoplasmic domains of these receptors might predict their function, recent findings show that differences in glycosylation of ligands can dramatically alter C-type lectin-like receptor usage.
D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000378:metabolism; D002450:Cell Communication; D003713:Dendritic Cells / Q000276:immunology; D019281:Dimerization; D004705:Endocytosis / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000378:metabolism*; D037181:Lectins, C-Type / Q000276:immunology / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000276:immunology; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D011956:Receptors, Cell Surface / Q000276:immunology / Q000378:metabolism; D011973:Receptors, LDL / Q000378:metabolism; D011975:Receptors, Mitogen / Q000378:metabolism*; D051131:Receptors, Oxidized LDL; D051127:Scavenger Receptors, Class E; D019087:Selectins / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology; D051193:Toll-Like Receptors; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011973:Receptors, LDL; D011975:Receptors, Mitogen; D051131:Receptors, Oxidized LDL; D051127:Scavenger Receptors, Class E; D019087:Selectins; D051193:Toll-Like Receptors; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C483616:ICAM3 protein, human; C495137:OLR1 protein, human