title: Use of semipreparative supercritical fluid chromatography to obtain small quantities of the albendazole sulfoxide enantiomers.
abstract: The semipreparative separation of the albendazole sulfoxide enantiomers using chiral supercritical fluid chromatography is presented in this work. For this purpose, a modular SFC chromatograph was adapted to work at semipreparative scale and a Chiralpak AD (250 x 10 mm) column was used. Different injection volumes were evaluated in order to obtain high purities and throughputs. Using the maximum load, it was possible to obtain 37 mg/h of the first eluted enantiomer with a purity of 99.9%, and 36.5 mg/h of the second eluted enantiomer with a purity of 95%.
mesh_terms: D015766:Albendazole / Q000031:analogs & derivatives* / Q000032:analysis*; D025924:Chromatography, Supercritical Fluid / Q000379:methods*; D013237:Stereoisomerism
chemical_list: D015766:Albendazole; C027186:albendazole sulfoxide