The apolipoprotein CIII T2854G variants are associated with postprandial triacylglycerol concentrations in normolipidemic Korean men.
This study investigated associations between the apolipoprotein (apo) CIII polymorphism and triacylglycerol (TAG) concentrations in fasting and postprandial plasma. Polymerase chain reaction followed by a restriction fragment length genotyping was conducted to assess the allele frequency of the apo CIII T2854G variants in healthy and normolipidemic Korean men ( n=262). Waist circumference, body mass index (kilograms per meter squared), fasting plasma concentrations of TAG, total cholesterol, high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), glucose, and insulin were compared across the genotypes. Compared to TT homozygotes and TG heterozygotes, GG homozygotes had 22% higher fasting TAG concentrations, respectively ( p<0.05). A subgroup of 60 subjects (TT homozygotes=20, TG heterozygotes=22, GG homozygotes= 18) were further invited to participate in a high-fat meal test to assess postprandial TAG concentrations. During the high-fat meal test, the GG homozygotes had 21% higher TAG area under the curve (AUC) than the TT homozygotes ( p<0.05) and 22% higher TAG AUC than the TG heterozygotes ( p<0.05). In conclusion, this is the first study to show that the apo CIII T2854G variants are associated with elevated postprandial TAG concentrations in the study population of Korean men.
D000328:Adult; D000483:Alleles; D053305:Apolipoprotein C-III; D001056:Apolipoproteins C / Q000235:genetics*; D001786:Blood Glucose / Q000032:analysis; D005215:Fasting; D005787:Gene Frequency; D005796:Genes; D006801:Humans; D007328:Insulin / Q000097:blood; D007723:Korea; D008055:Lipids / Q000097:blood; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D019518:Postprandial Period; D014280:Triglycerides / Q000097:blood*
D053305:Apolipoprotein C-III; D001056:Apolipoproteins C; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D014280:Triglycerides