[Reduction of local and systemic complications of acute pancreatitis by monoclonal antibody to ICAM-1].
The prognosis of acute necrotizing pancreatitis is dependent on systemic complications. The endothelial adhesion molecule ICAM-1 mediates both leukocyte adhesion and migration. Expression of ICAM-1 was investigated at various time points in mild and severe necrotizing pancreatitis in the pancreas, lungs and intestine. A possible therapeutic effect of monoclonal antibodies against ICAM-1 was evaluated in severe necrotizing disease. The expression of ICAM-1 preceded the fulminant leukocyte Infiltration of the organs. In contrast to mild pancreatitis, ICAM-1 expression was increased at an earlier time point and systemically in severe necrotizing disease. Treatment with antibodies against ICAM-1 improved microcirculation and reduced local and systemic organ damage in severe pancreatitis.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects / Q000276:immunology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology*; D007422:Intestines / Q000276:immunology / Q000473:pathology; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D007964:Leukocytosis / Q000276:immunology; D008168:Lung / Q000276:immunology / Q000473:pathology; D008297:Male; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications* / Q000276:immunology* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley
D000911:Antibodies, Monoclonal; D018799:Intercellular Adhesion Molecule-1