title: Cutaneous metastasis of osteosarcoma.
abstract: Cutaneous metastases of solid tumors have been reported with a frequency that ranges from 0.7% to 4.4% with recent studies reporting 9% and 10%. Osteosarcomas seldom metastasize to the skin. The most frequent metastatic sites are to the lungs, bones, and kidneys. We report 2 cases of osteosarcoma that metastasized to the skin. A 75-year-old patient with known osteosarcoma of the tibia developed cutaneous nodules overlying the site of the primary tumor. A 46-year-old woman with a history of osteosarcoma of the knee developed a nodule on her scalp. Histologic examination of both lesions revealed metastatic osteosarcoma. This is a rare event that, to our knowledge, has previously only been reported 6 times.
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012516:Osteosarcoma / Q000473:pathology / Q000556:secondary*; D012535:Scalp; D012878:Skin Neoplasms / Q000556:secondary*; D013977:Tibia