title: Punctal-canalicular stenosis associated with mitomycin-C for corneal epithelial dysplasia.
abstract: OBJECTIVE
  To report a case of punctal-canalicular stenosis after topical mitomycin C use for corneal dysplasia. To the authors' knowledge, this association has not previously been described.
  
  
  METHODS
  Observational case report.
  
  
  METHODS
  A 62-year-old woman was noted to have a right inferotemporal corneal dysplastic lesion. She received a topical course of mitomycin-C 0.04% four times a day, which subsequently invoked a toxoallergic reaction. One month later, the patient developed right-sided epiphora.
  
  
  RESULTS
  Probing demonstrated complete stenosis of the right lower canaliculus, 5 mm from the punctum.
  
  
  CONCLUSIONS
  Mitomycin-C use may lead to lacrimal apparatus fibrosis and symptomatic epiphora when inciting a toxoallergic reaction.
mesh_terms: D000287:Administration, Topical; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects*; D003316:Corneal Diseases / Q000188:drug therapy*; D005260:Female; D005355:Fibrosis; D006801:Humans; D007767:Lacrimal Duct Obstruction / Q000139:chemically induced* / Q000175:diagnosis; D008875:Middle Aged; D016685:Mitomycin / Q000009:adverse effects*; D009301:Nasolacrimal Duct / Q000187:drug effects* / Q000473:pathology
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin