DNA gyrase and topoisomerase IV mutations in clinical isolates of Ureaplasma spp. and Mycoplasma hominis resistant to fluoroquinolones.
Twelve clinical isolates of Ureaplasma spp. and one isolate of Mycoplasma hominis were examined for resistance to fluoroquinolones. Previously described mutations at positions 83 and 95 in GyrA (Escherichia coli numbering) and positions 80 and 87 in ParC were found. Unusual alterations were described at positions ParC 123 and 134.
D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution; D027081:DNA Gyrase / Q000235:genetics*; D027101:DNA Topoisomerase IV / Q000235:genetics*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005260:Female; D024841:Fluoroquinolones / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009154:Mutation; D019535:Mycoplasma hominis / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D014509:Ureaplasma / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*
D024841:Fluoroquinolones; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase