Brain-derived neurotrophic factor shows a protective effect and improves recovery of the ERG b-wave response in light-damage.
We investigated the neuroprotective effects of brain-derived neurotrophic factor (BDNF) and its influence on the functional recovery of the retina following light-induced retinal damage by electroretinogram (ERG). Rats were exposed to constant fluorescent light for 2, 5, 7, or 14 days, then returned to a cyclic light environment for 14 days. The result indicated that BDNF had few effects on the a-wave amplitude, but there was a statistically significant difference in the b-wave amplitudes between BDNF-treated and control eyes from day 0-14 of the recovery period following 2 days of light exposure (p < 0.05). Our findings suggest that BDNF not only protects the retinal neuronal function but also enhances the recovery from retinal light damage.
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000008:administration & dosage / Q000494:pharmacology*; D004333:Drug Administration Routes; D004596:Electroretinography / Q000187:drug effects*; D008027:Light / Q000009:adverse effects*; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function / Q000187:drug effects*; D012160:Retina / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D016896:Treatment Outcome
D019208:Brain-Derived Neurotrophic Factor; D018696:Neuroprotective Agents