title: Mesial temporal lobe epilepsy: a pathological replay of developmental mechanisms?
abstract: Focal epilepsies of the mesial temporal lobe are often associated with a hippocampal sclerosis. Changes in Cl homeostasis and GABAergic signalling in downstream regions, may contribute to the human pathology. A review of changes in cellular and synaptic function and connectivity after de-afferentation suggests this epileptic syndrome may involve a pathological replay of developmental mechanisms.
mesh_terms: D000818:Animals; D001921:Brain / Q000196:embryology*; D002712:Chlorides / Q000378:metabolism; D004569:Electroencephalography; D004827:Epilepsy / Q000473:pathology*; D004833:Epilepsy, Temporal Lobe / Q000196:embryology* / Q000473:pathology*; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D012598:Sclerosis / Q000473:pathology; D015398:Signal Transduction; D013569:Synapses / Q000378:metabolism; D013702:Temporal Lobe / Q000473:pathology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D002712:Chlorides; D005680:gamma-Aminobutyric Acid