Development of the drug release system in hole transfer reaction through DNA.
DNA is known as a good hole carrier, and the application for a molecular wire has been studied. The efficiency of hole transfer was estimated as band intensity of phosphorimagery after electrophoresis in polyacrylamide gel. For the application of long-range hole transport through DNA to gene diagnosis and electrochemical technology, the hole transport without complicated and unwieldy analyzing processes is strongly desired. Herein, we developed novel nucleosides, which release various function units by oxidation. We synthesized novel nucleosides, which were designed based on the chemistry of an efficient hole trapping nucleoside 8-methoxy G.
D004247:DNA / Q000737:chemistry*; D004591:Electrophoresis, Polyacrylamide Gel
D004247:DNA