title: Tackling an essential problem in functional proteomics of Saccharomyces cerevisiae.
abstract: Gene inactivation is the cornerstone of functional genetic analysis, but the analysis of essential genes requires conditional inactivation of the gene product. A new study has adapted a simple method for creating conditional alleles to allow large-scale analysis of essential genes in Saccharomyces cerevisiae and has identified a role in DNA replication for a newly identified protein complex.
mesh_terms: D004261:DNA Replication; D005656:Fungal Proteins / Q000235:genetics* / Q000378:metabolism*; D020043:Genes, Essential / Q000235:genetics / Q000502:physiology*; D018816:Genes, cdc / Q000502:physiology; D040901:Proteomics / Q000379:methods*; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D005656:Fungal Proteins