Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase.
Synthesis of a new asymmetric bisquaternary reactivator of tabun-inhibited acetylcholinesterase-1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide is described. Reactivation potency of this oxime is compared to the currently used reactivators-pralidoxime, obidoxime and H-oxime HI-6.
D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D004793:Enzyme Reactivators / Q000138:chemical synthesis*; D007700:Kinetics; D010755:Organophosphates / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D004793:Enzyme Reactivators; D010755:Organophosphates; C009374:tabun