title: Strain-derived canalicular fluid flow regulates osteoclast activity in a remodelling osteon--a proposal.
abstract: The concept of bone remodelling by basic multicellular units is well established, but how the resorbing osteoclasts find their way through the pre-existing bone matrix remains unexplained. The alignment of secondary osteons along the dominant loading direction suggests that remodelling is guided by mechanical strain. This means that adaptation (Wolff's Law) takes place throughout life at each remodelling cycle. We propose that alignment during remodelling occurs as a result of different canalicular flow patterns around cutting cone and reversal zone during loading. Low canalicular flow around the tip of the cutting cone is proposed to reduce NO production by local osteocytes thereby causing their apoptosis. In turn, osteocyte apoptosis could be the mechanism that attracts osteoclasts, leading to further excavation of bone in the direction of loading. At the transition between cutting cone and reversal zone, however, enhanced canalicular flow will stimulate osteocytes to increase NO production, which induces osteoclast retraction and detachment from the bone surface. Together, this leads to a treadmill of attaching and detaching osteoclasts in the tip and the periphery of the cutting cone, respectively, and the digging of a tunnel in the direction of loading.
mesh_terms: D001696:Biomechanical Phenomena; D001857:Bone Matrix; D016723:Bone Remodeling / Q000502:physiology*; D045604:Extracellular Fluid / Q000502:physiology*; D006253:Haversian System / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D010010:Osteoclasts / Q000502:physiology*; D012212:Rheology; D016138:Walking / Q000502:physiology*; D016474:Weight-Bearing