[Oxygen-dependent metabolism of neutrophils and monocytes in patients with unstable angina pectoris and its correction with preductal].
Spectrophotometric NBT-test and luminol-dependent chemiluminescence were used to study oxygen-dependent metabolism of neutrophils and monocytes; antioxidant defense was evaluated by activity of superoxide dismutase measured by spectrophotomety and peroxide chemiluminescence of blood plasma; heparin and trimetasidine (preductal) effects on the above metabolism were studied in 39 patients with unstable angina pectoris. All the patients were found to have a significant rise in functional activity of neutrophils and monocytes by NBT-test and insignificant one by chemiluminescence, unchanged activity of serum superoxide dismutase, reduced total antioxidant potential of blood serum, moderate elevation of circulating immune complexes in high parameters of NBT-test. The latter points to a mild activation of leukocytes through FcR or CR and suggests the presence of another activator of membrane NADP.H-oxidase in unstable angina. Use of heparin in unstable angina activated oxygen-dependent metabolism of neutrophils and monocytes in the absence of reduction in the degree and extent of ischemic myocardial damage. This reduction was observed in the treatment of unstable angina with preductal. This effect is due to suppression, primarily, of NADP.H- and NAD.H-oxidase of leukocytes. It also demonstrates antioxidant properties of this drug.
D000789:Angina, Unstable / Q000097:blood* / Q000188:drug therapy; D005343:Fibrinolytic Agents / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D014292:Trimetazidine / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000627:therapeutic use
D005343:Fibrinolytic Agents; D014665:Vasodilator Agents; D006493:Heparin; D014292:Trimetazidine; D010100:Oxygen