title: Space-time relationship in continuously moving table method for large FOV peripheral contrast-enhanced magnetic resonance angiography.
abstract: Data acquisition using a continuously moving table approach is a method capable of generating large field-of-view (FOV) 3D MR angiograms. However, in order to obtain venous contamination-free contrast-enhanced (CE) MR angiograms in the lower limbs, one of the major challenges is to acquire all necessary k-space data during the restricted arterial phase of the contrast agent. Preliminary investigation on the space-time relationship of continuously acquired peripheral angiography is performed in this work. Deterministic and stochastic undersampled hybrid-space (x, k(y), k(z)) acquisitions are simulated for large FOV peripheral runoff studies. Initial results show the possibility of acquiring isotropic large FOV images of the entire peripheral vascular system. An optimal trade-off between the spatial and temporal sampling properties was found that produced a high-spatial resolution peripheral CE-MR angiogram. The deterministic sampling pattern was capable of reconstructing the global structure of the peripheral arterial tree and showed slightly better global quantitative results than stochastic patterns. Optimal stochastic sampling patterns, on the other hand, enhanced small vessels and had more favourable local quantitative results. These simulations demonstrate the complex spatial-temporal relationship when sampling large FOV peripheral runoff studies. They also suggest that more investigation is required to maximize image quality as a function of hybrid-space coverage, acquisition repetition time and sampling pattern parameters.
mesh_terms: D000465:Algorithms; D015901:Angiography, Digital Subtraction / Q000295:instrumentation / Q000379:methods*; D001161:Arteriosclerosis / Q000000981:diagnostic imaging*; D003198:Computer Simulation; D003287:Contrast Media; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000295:instrumentation / Q000379:methods*; D008955:Models, Cardiovascular; D009038:Motion; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014915:Whole-Body Counting / Q000295:instrumentation / Q000379:methods*
chemical_list: D003287:Contrast Media