The cytokine receptor gp130: faithfully promiscuous.
Diverse cytokines can signal through receptor complexes containing the gp130 subunit. These cytokines, which include interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and CLC (cardiotrophin-like cytokine), are implicated in inflammatory and immune responses, heart development, and fertility. The gp130 receptor-ligand complexes are contrasted with the complex formed by erythropoietin (Epo) and its receptor, EpoR. Also discussed are insights provided by the structural analysis of IL-6, its alpha receptor (IL6Ralpha), and the signal transducer gp130 for understanding receptor-ligand assembly, for predicting the structures of ligand-receptor complexes of the other IL-6-type cytokines, and for rational drug design.
D015703:Antigens, CD / Q000502:physiology*; D050822:Cytokine Receptor gp130; D016207:Cytokines / Q000378:metabolism*; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D015703:Antigens, CD; D016207:Cytokines; C494199:IL6ST protein, human; D008562:Membrane Glycoproteins; D050822:Cytokine Receptor gp130