Structure and physicochemical properties of diastereomeric isomers of ApA.
Heterochiral ApAs (ALpAD and ADpAL) together with homochiral D-(ApA) and L-(ApA) were synthesized and their helical structures were investigated by using spectroscopic techniques. The results indicate that the chirality of the 3'-end residue is the primary determinant for the helical sense of adenylyl-(3'-5')-adenosine (ApA).
D002942:Circular Dichroism; D015226:Dinucleoside Phosphates / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D015226:Dinucleoside Phosphates; C006412:adenylyl-(3'-5')-adenosine