The synthesis of SO-3, a conopeptide with high analgesic activity derived from Conus striatus.
The synthesis and characterization of the conopeptide, SO-3, originally derived from Conus striatus is reported. It contains 25 amino acid residues and three disulfide bridges and manifests 72% sequence identity with MVIIA, an N-type Ca2+ channel inhibitor of high analgesic activity. We evaluated SO-3 in several mouse models of pain. The results indicate that SO-3 is a potent, nonaddictive, analgesic agent.
D000595:Amino Acid Sequence; D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020916:Conotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006054:Goldfish; D051379:Mice; D023421:Models, Animal; D008969:Molecular Sequence Data; D010146:Pain; D010455:Peptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017510:Protein Folding; D051381:Rats; D012908:Snails / Q000737:chemistry*
D000700:Analgesics; D002121:Calcium Channel Blockers; D020916:Conotoxins; D010455:Peptides; C482173:SO-3 conopeptide, Conus striatus