Birt-Hogg-Dubé syndrome: two patients with neural tissue tumors.
We present 2 unrelated patients found to have tumors of neural tissue origin, a neurothekeoma and a meningioma, who were additionally diagnosed with the syndrome of Birt-Hogg-Dubé (BHDS). We are unaware of previous BHDS patients with neural tissue tumors. In light of recent linkage analysis studies delineating the genetic susceptibility locus for BHDS, we speculate about a possible association between BHDS and neural tissue tumors.
D000328:Adult; D006223:Hamartoma Syndrome, Multiple / Q000235:genetics*; D006801:Humans; D008579:Meningioma / Q000235:genetics*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D018321:Neurothekeoma / Q000235:genetics*; D009669:Nose Neoplasms / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics*