Osteoclastogenesis inhibitory factor/osteoprotegerin in synovial fluid from patients with temporomandibular disorders.
The goal of this study was to measure the activities of osteoclastogenesis inhibitory factor/osteoprotegerin (OCIF/OPG), interleukin-1beta (IL-1beta), and tumour necrosis factor-alpha (TNF-alpha) in synovial fluid from 24 patients with internal derangement and 26 with osteoarthritis of the temporomandibular joint (TMJ). Five asymptomatic healthy volunteers were studied as control. Concentrations of OCIF/OPG, IL-1beta, and TNF-alpha were determined by enzyme-linked immunosorbent assay. The mean OCIF/OPG concentration in the patients with osteoarthritis (71 pg/ml) was significantly lower than those in the patients with internal derangement (160 pg/ml, P< 0.05) and the healthy volunteers (196 pg/ml, P< 0.01). In contrast, the IL-1beta and TNF-alpha concentrations were similar in all three groups. These results suggest that OCIF/OPG is associated with the pathogenesis of osteoarthritis of the TMJ. Perhaps, decreased OCIF/OPG concentrations promote osteoclastic activity and induce osteoarthritis of the TMJ.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis; D004204:Joint Dislocations / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism; D053244:Osteoprotegerin; D018160:Receptors, Cytoplasmic and Nuclear / Q000032:analysis*; D018124:Receptors, Tumor Necrosis Factor / Q000032:analysis*; D013582:Synovial Fluid / Q000737:chemistry*; D013705:Temporomandibular Joint Disorders / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D006023:Glycoproteins; D007375:Interleukin-1; D053244:Osteoprotegerin; D018160:Receptors, Cytoplasmic and Nuclear; D018124:Receptors, Tumor Necrosis Factor; C506030:TNFRSF11B protein, human; D014409:Tumor Necrosis Factor-alpha