title: A convenient synthesis of the beraprost intermediate: a useful method for introducing a C3 unit at the benzyl position.
abstract: [reaction: see text] The Heck reaction is a more efficient and reliable method than previous ones for introducing a C3 unit at the benzyl position for the synthesis of Beraprost. Especially, trialkylated long-chain amines such as (n-C(8)H(17))(3)N and (n-C(12)H(25))(3)N resulted in good yields. This development will be used for the industrial synthesis of Beraprost.
mesh_terms: D001593:Benzyl Compounds / Q000737:chemistry*; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001593:Benzyl Compounds; C048081:beraprost; D011464:Epoprostenol