[Severe trauma leads to damaged signal transduction with inhibited secretion of cytokines].
The reduced secretion if IL-1 beta after severe injury seems to be due to disturbances in signal transduction pathways. Protein-tyrosine kinases are necessary for endotoxin-induced secretion of IL-1 beta, while protein kinase C antagonizes this effect.
D016207:Cytokines / Q000097:blood*; D004926:Escherichia coli / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000097:blood*; D008070:Lipopolysaccharides / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D009104:Multiple Trauma / Q000276:immunology*; D011493:Protein Kinase C / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D016207:Cytokines; D007375:Interleukin-1; D008070:Lipopolysaccharides; D011505:Protein-Tyrosine Kinases; D011493:Protein Kinase C