title: [Effect of pneumoperitoneum on hemodynamics and intestinal integrity in endotoxinemia: CO2 versus helium].
abstract: In a study in pigs pathophysiological effects of a pneumoperitoneum (PP) established during endotoxemia (2 micrograms/kg b.w./hr) were investigated. In this situation a PP with carbon dioxide (CO2) or helium induces a deterioration of systemic hemodynamics or acid-base-stability. Some of these effects threaten vital stability. PP with either gas causes a mucosal acidosis of the small bowel within the meaning of an impairment of intestinal oxygen supply. A CO2-PP adversely affects the intestinal energy metabolism and leads to significantly increased endotoxin levels in contrast to helium after desufflation of the abdominal cavity. Data of this study at least demand for a careful monitoring, if laparoscopy is performed in septic and critically ill patients.
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002245:Carbon Dioxide / Q000494:pharmacology*; D019446:Endotoxemia / Q000503:physiopathology*; D004734:Energy Metabolism / Q000502:physiology; D006371:Helium / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology*; D007413:Intestinal Mucosa / Q000503:physiopathology; D010101:Oxygen Consumption / Q000502:physiology; D010537:Peritoneum / Q000503:physiopathology; D011028:Pneumoperitoneum, Artificial / Q000379:methods*; D013552:Swine; D018746:Systemic Inflammatory Response Syndrome / Q000503:physiopathology*
chemical_list: D002245:Carbon Dioxide; D006371:Helium