Copper interaction on the long-term potentiation.
The role of copper on the CA1 piramidal neurons and their sinaptic connections to the Schaffer's collateral was investigated using the field excitatory post-sinaptic potential (fEPSP). The same fEPSP was used to study copper effects on Long-term potentiation (LTP). We have found that copper 10 microM has an inhibitory action on the fEPSP. Similar effects were demonstrated with 10 microM of GABA. Moreover, copper showed a strong inhibitory action on the consolidated LTP. However, copper washout left a significant and persistent excitatory response. In our opinion, copper shows a dual sinaptic effect depending on the sinaptic experience.
D000818:Animals; D003300:Copper / Q000494:pharmacology*; D019327:Copper Sulfate / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions / Q000502:physiology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D006527:Hepatolenticular Degeneration / Q000378:metabolism / Q000503:physiopathology; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000503:physiopathology; D009924:Organ Culture Techniques; D017729:Presynaptic Terminals / Q000378:metabolism*; D017966:Pyramidal Cells / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism / Q000494:pharmacology
D005680:gamma-Aminobutyric Acid; D003300:Copper; D019327:Copper Sulfate