What we have learned about prokaryotes from structural genomics.
Five years ago systematic determination and theoretical analysis of all protein structures encoded in model prokaryotic organisms was proposed as a powerful way to obtain new insights into protein function and the variety of protein folds. What has been the pay-off from studying structures in genomic context? Have we learned anything new about protein structure? Can we now predict protein function better? In this contribution, I summarize the status of large-scale structure determination projects on prokaryotes and provide an overview of the main results obtained from experimental and theoretical studies in this dynamic research field.
D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics; D019143:Evolution, Molecular; D023281:Genomics / Q000379:methods*; D016366:Open Reading Frames / Q000235:genetics; D011387:Prokaryotic Cells / Q000378:metabolism*; D017510:Protein Folding; D017434:Protein Structure, Tertiary / Q000235:genetics
D001426:Bacterial Proteins