Peripheral nerve induces macrophage neurotrophic activities: regulation of neuronal process outgrowth, intracellular signaling and synaptic function.
Rat cortical neurons cultured in conditioned media from human monocyte-derived macrophages (MDM) show increased neuronal protein synthesis, neurite outgrowth, mitogen-activating protein kinase activity, and synaptic function. Neurotrophic properties of human MDM-conditioned media are significantly enhanced by human peripheral nerve and to a more limited extent by CD40 ligand pre-stimulation. Such positive effects of MDM secretions on neuronal function parallel the secretion of brain-derived neurotrophic factor (BDNF). MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration.
D000328:Adult; D000818:Animals; D001917:Brachial Plexus / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D002470:Cell Survival / Q000502:physiology; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000201:enzymology / Q000502:physiology; D017077:Culture Media, Conditioned / Q000378:metabolism / Q000494:pharmacology; D006624:Hippocampus / Q000502:physiology; D006801:Humans; D007424:Intracellular Fluid / Q000201:enzymology / Q000502:physiology*; D020935:MAP Kinase Signaling System / Q000502:physiology; D008262:Macrophage Activation / Q000502:physiology*; D008264:Macrophages / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology; D009414:Nerve Growth Factors / Q000096:biosynthesis* / Q000502:physiology; D016501:Neurites / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000201:enzymology / Q000502:physiology; D010749:Phosphoprotein Phosphatases / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D015290:Second Messenger Systems / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*; D015854:Up-Regulation / Q000502:physiology
D017077:Culture Media, Conditioned; D009414:Nerve Growth Factors; C049301:microtubule-associated protein-2 phosphatase; D010749:Phosphoprotein Phosphatases