A new type of cysteine proteinase inhibitor--the salarin gene from Atlantic salmon (Salmo salar L.) and Arctic charr (Salvelinus alpinus).
Salarin is a 43 kDa glycoprotein which is found so far only in salmonid fish species. It is a strong inhibitor of cysteine proteinases. Here we characterised the salarin gene from Atlantic salmon and cDNA from Arctic charr. The salarin gene has 13 exons and 1026 bp long coding sequence. The translated amino acid sequence has four similar domains. The sequence resembles the proregion of cathepsins, known to inhibit cysteine proteinases. Salarin can be a new type of cysteine proteinase inhibitor.
D000595:Amino Acid Sequence; D000818:Animals; D003546:Cysteine Endopeptidases / Q000378:metabolism; D015853:Cysteine Proteinase Inhibitors / Q000235:genetics* / Q000494:pharmacology; D018076:DNA, Complementary / Q000235:genetics; D029941:Fish Proteins; D006023:Glycoproteins / Q000235:genetics* / Q000494:pharmacology; D008969:Molecular Sequence Data; D020317:Salmo salar / Q000235:genetics*; D014337:Trout / Q000235:genetics*
D015853:Cysteine Proteinase Inhibitors; D018076:DNA, Complementary; D029941:Fish Proteins; D006023:Glycoproteins; C403188:salarin protein, Salmo salar; D003546:Cysteine Endopeptidases