[Anxiolytic effect of the dehydroepiandrosterone sulfate: mu-opioid mechanism].
Effects of dehydroepiandrosterone sulfate (DHEAS, 30 mg/kg, i/p, 4 and 28 hours after injection) on CBA/Lac male mice with increased level of anxiety resulting from chronic (20-days) social confrontations in two behavioral anxiety-estimated tests, were studied. The anxiolytic effect of DHEAS was discovered within 4 hours after injection in the "partition test" of social interactions and within 28 hours in "plus-maze test". Naltrexone (0.25 mg/kg, for 20 min before DHEAS injection) blocked this effect.
D000374:Aggression / Q000523:psychology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000209:etiology / Q000378:metabolism / Q000523:psychology*; D003163:Competitive Behavior / Q000187:drug effects; D019314:Dehydroepiandrosterone Sulfate / Q000494:pharmacology*; D004291:Dominance-Subordination; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D009271:Naltrexone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012930:Social Dominance; D013315:Stress, Psychological / Q000150:complications* / Q000378:metabolism
D014151:Anti-Anxiety Agents; D009292:Narcotic Antagonists; D017450:Receptors, Opioid, mu; D019314:Dehydroepiandrosterone Sulfate; D009271:Naltrexone