title: Prenatal exposure to alcohol alters the light response in postnatal circadian rhythm.
abstract: We studied the effect of prenatal exposure to alcohol on later circadian rhythm in the rat. In the normal light-dark cycle, an 8-h phase advance brought forward the deep body temperature rhythm in control rats, although it had a smaller effect in prenatally ethanol-exposed rats. In long constant darkness, the phase response of the deep body temperature rhythm to a light pulse at the early subjective night was less marked in ethanol-exposed rats in comparison to controls. These results indicate that prenatal exposure to alcohol has a long-lasting effect on the light responsiveness of the deep body temperature circadian rhythm.
mesh_terms: D000818:Animals; D001831:Body Temperature; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000187:drug effects*; D003624:Darkness; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D008027:Light; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol