[The modulating role of essential and non-essential amino acids in organotypic tissue culture in rats of different ages].
The effect of amino acids L-lysin, L-asparagin, L-arginin, L-glutamate was investigated in organotypic tissue culture of spleen, liver and brain cortex of rats at different age. The amino acids in concentration 0.05 ng/ml are active inducing a less intensive growth zone, as compared to control, in 1-day and in older rats--an intensive growth zone, as compared to control in 21-day rats. The data obtained suggest a modulating role of amino acids in the tissues at different stages of maturation.
D000375:Aging / Q000502:physiology*; D000596:Amino Acids / Q000494:pharmacology*; D000601:Amino Acids, Essential / Q000494:pharmacology; D000818:Animals; D001120:Arginine / Q000494:pharmacology; D001216:Asparagine / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D003470:Culture Media; D018698:Glutamic Acid / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology; D008239:Lysine / Q000494:pharmacology; D009924:Organ Culture Techniques; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects* / Q000254:growth & development / Q000502:physiology
D000596:Amino Acids; D000601:Amino Acids, Essential; D003470:Culture Media; D018698:Glutamic Acid; D001216:Asparagine; D001120:Arginine; D008239:Lysine