Immune complex associated complications in the subacute phase of meningococcal disease: incidence and literature review.
OBJECTIVE
To determine the incidence of immune complex associated complications (IAC) after severe meningococcal disease (SMD) in a group of Dutch children admitted to a paediatric intensive care unit (PICU).


METHODS
Retrospective chart analysis and follow up of 130 survivors of SMD admitted to PICU. Signs of IAC, inflammatory parameters, and temperature profile were reviewed.


RESULTS
Of 130 children with SMD, 20 (15.3%) showed one or more of the three manifestations of IAC: 18 (13.8%) developed arthritis (effusion, with or without erythema/arthralgia), 11 (8.4%) vasculitis, and five (3.8%) pleuritis. Eighteen of 20 (90%) patients with IAC had a secondary rise in temperature; in patients with no IAC this was 48 of 110 (43.6%). IAC was associated with leucocytosis in 82.3% versus 47.7% in patients without IAC, and with increased CRP in 86.6% versus 47.2% in patients without IAC. Leucocytes on admission were significantly lower in patients who would later develop IAC (mean 8.6 versus 13.8x10(9)/l).


CONCLUSIONS
IAC is a common complication of SMD, mainly occurring 4-10 days after systemic disease. IAC presents clinically as arthritis or vasculitis, mostly accompanied by secondary fever and raised inflammatory parameters.
D000293:Adolescent; D016918:Arthritis, Reactive / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000150:complications; D006801:Humans; D007105:Immune Complex Diseases / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D015994:Incidence; D007223:Infant; D007902:Length of Stay; D007964:Leukocytosis / Q000150:complications; D008297:Male; D008589:Meningococcal Infections / Q000150:complications* / Q000276:immunology; D009426:Netherlands / Q000453:epidemiology; D010998:Pleurisy / Q000276:immunology; D012189:Retrospective Studies; D014657:Vasculitis / Q000276:immunology