Bacterial RNase P as a potential target for novel anti-infectives.
The diversity of higher-order structure in ribonucleoprotein (RNP) complexes makes them amenable to small-molecule modulation of their biological function. This review will discuss why bacterial RNase P, a simple yet essential ubiquitous and highly conserved RNP enzyme, represents an excellent target for the discovery and development of novel antimicrobials.
D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D021122:Protein Subunits / Q000378:metabolism; D012329:RNA, Bacterial / Q000378:metabolism*; D043262:Ribonuclease P / Q000037:antagonists & inhibitors*; D013379:Substrate Specificity
D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D021122:Protein Subunits; D012329:RNA, Bacterial; D043262:Ribonuclease P