Lactating females Syrian hamster (Mesocricetus auratus) show protection against experimental Leishmania infantum infection.
The Syrian hamster (Mesocricetus auratus) is the best animal model for human leishmaniosis, an emergent disease that causes 400,000 new cases every year. The main objective of this assay was to prove the relationship between female lactation, which implies hyperprolactinaemia (IFN-gamma, IL-12, IL-2 and TNF-alpha elevated), and leishmaniosis (IFN-gamma, IL-12, IL-2 and TNF-alpha diminished). The results demonstrate the clear implication of lactation in immune response. The infected lactating females did not show any symptoms of sickness, a 24 g mean increase was noticed, throughout the assay they were negative in the indirect diagnosis test (Direct Agglutination Test (DAT)), and in the direct diagnosis tests (N-N-N isolation, tissue impressions).
D000372:Agglutination Tests; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D001835:Body Weight; D001853:Bone Marrow / Q000469:parasitology; D006224:Cricetinae; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007774:Lactation / Q000276:immunology*; D018314:Leishmania infantum / Q000276:immunology*; D007898:Leishmaniasis, Visceral / Q000276:immunology*; D008099:Liver / Q000469:parasitology; D008647:Mesocricetus; D013154:Spleen / Q000469:parasitology
D000913:Antibodies, Protozoan