Synthesis of oligonucleoside phosphorodithioates by the H-phosphonothioate method using bis(2,6-dimethylphenyl)phosphorochloridate as a coupling agent.
The phosphorodithioate octamer [(TpS2)7T] was efficiently synthesized using bis(2,6-dimethylphenyl)phosphorochloridate as a coupling agent by the H-phosphonothioate method, which performed the sulfurization with elemental sulfur after completion of oligonucleoside H-phosphonothioate assembly, as the standard H-phosphonate method.
D002851:Chromatography, High Pressure Liquid; D009705:Nucleosides / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry
D009705:Nucleosides; D009943:Organophosphorus Compounds; D013455:Sulfur