Experimental hyperkalaemia in rabbits: effects of salbutamol and norepinephrine treatments on blood biochemistry and electrocardiography.
The effects of salbutamol and norepinephrine on the electrocardiogram (ECG), serum potassium level and enzyme activities were studied in rabbits with hyperkalaemia; norepinephrine and salbutamol may be therapeutically useful. For induction of hyperkalaemia, 300 mM KCl solution was used and then isotonic saline solution containing 6 microg salbutamol and 3.9 microg norepinephrine per ml were administered. Norepinephrine and salbutamol decreased the serum potassium from 7.36 +/- 0.26 and 7.21 +/- 0.31 mmol/L to 5.62 +/- 0.27 and 4.35 +/- 0.33 mmol/L, respectively, and caused the ECG changes (flatness of P wave, widening of QRS complex and bradycardia) to return to the control conditions (time 0). Norepinephrine, but not salbutamol, decreased the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) to the control levels. These results suggest that monitoring of the enzyme activities might be useful as it yields indexes suitable for evaluating the therapeutic approach with norepinephrine in hyperkalaemia.
D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage* / Q000494:pharmacology; D000318:Adrenergic beta-Agonists / Q000008:administration & dosage* / Q000494:pharmacology; D000410:Alanine Transaminase / Q000097:blood / Q000187:drug effects; D000420:Albuterol / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood / Q000187:drug effects; D001774:Blood Chemical Analysis / Q000662:veterinary; D004562:Electrocardiography / Q000187:drug effects / Q000662:veterinary; D005260:Female; D006947:Hyperkalemia / Q000188:drug therapy / Q000662:veterinary*; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000187:drug effects; D009638:Norepinephrine / Q000008:administration & dosage* / Q000494:pharmacology; D011188:Potassium / Q000097:blood*; D011817:Rabbits
D000316:Adrenergic alpha-Agonists; D000318:Adrenergic beta-Agonists; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000420:Albuterol; D011188:Potassium; D009638:Norepinephrine