In vitro influence of ciprofloxacin on selected functions of rainbow trout (Oncorhynchus mykiss) leucocytes.
The in vitro influence of ciprofloxacin on the metabolic activity of phagocytes and the proliferative response of lymphocytes on the specific mitogens in rainbow trout were assessed. It was found that the cell ability to produce reactive oxygen species remained unchanged. Suppressive effects of ciprofloxacin on lymphocyte reactivity at relatively low concentrations were noted. T cells were more sensitive to the toxic action of the drug than B cells.
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007962:Leukocytes / Q000187:drug effects*; D017686:Oncorhynchus mykiss / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects
D000890:Anti-Infective Agents; D002939:Ciprofloxacin