[Significance of allopeptide-induced expression of Fas ligand (FasL) in parenchyma of allogenic heart transplants as the cause of donor-specific tolerance induction].
This study proves the tolerogenicity of polymorphic allopeptides. Combined administration of peptides derived from the alpha 1 (intrathymal) and the alpha 2 (intraperitoneal) helical region of the donor RT1.A(a) molecule induced specific tolerance in a rat model of cardiac allotransplantation. The underlying tolerance mechanism was mediated by selective depletion of alloreactive T cells within the thymus and Fas-L-induced apoptosis within the graft.
D000818:Animals; D053222:Fas Ligand Protein; D006084:Graft Rejection / Q000276:immunology* / Q000473:pathology; D006085:Graft Survival / Q000276:immunology*; D016027:Heart Transplantation / Q000276:immunology* / Q000473:pathology; D006649:Histocompatibility Antigens / Q000276:immunology / Q000494:pharmacology*; D007108:Immune Tolerance / Q000276:immunology*; D007124:Immunoenzyme Techniques; D008562:Membrane Glycoproteins / Q000378:metabolism*; D009206:Myocardium / Q000276:immunology / Q000473:pathology; D010455:Peptides / Q000276:immunology / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D014184:Transplantation, Homologous
D053222:Fas Ligand Protein; C505662:Faslg protein, rat; D006649:Histocompatibility Antigens; D008562:Membrane Glycoproteins; D010455:Peptides; C038353:histocompatibility antigens RT, rat