[HNPCC-associated stomach carcinomas display aggressive growth in orthotopic transplantation to the SCID mouse].
The accumulation of malignant tumors in a single family, as well as the early onset of the disease, are highly suggestive of a hereditary condition. The evidence of microsatellite instabilities suggest a disease that might be associated with the HNPCC-syndromee. In contrary to the favourable prognosis of colorectal cancer associated with the HNPCC-syndromee we found in our animal model a far more aggressive progression of the disease in patients with HNPCC-associated gastric carcinomas than in patients with sporadic gastric carcinomas. This observation is consistent with the clinical course. Therefore, gastric carcinomas that are associated with the HNPCC-syndromee seem to represent a separate group of HNPCC-associated carcinomas and may even represent another hereditary disease.
D000818:Animals; D002455:Cell Division / Q000235:genetics / Q000502:physiology*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics / Q000473:pathology*; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D051379:Mice; D016513:Mice, SCID; D018895:Microsatellite Repeats / Q000235:genetics; D009362:Neoplasm Metastasis / Q000235:genetics / Q000473:pathology; D009368:Neoplasm Transplantation; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology*; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000235:genetics / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000473:pathology