title: Do zopiclone, zolpidem and flunitrazepam have residual effects on simulated task of collision anticipation?
abstract: Few studies have addressed the modifications in visual information processing brought about by taking hypnotic substances. The present experiment with healthy subjects investigated the residual effects of taking a single night-time dose of hypnotics on collision anticipation capacities the next morning. Visual sequences simulated the movement of a driver approaching an intersection where another vehicle was arriving. Ten participants had to estimate, as quickly as possible, whether the other vehicle would arrive before or after them at the intersection. They were tested after having taken a capsule of zolpidem (10 mg), zopiclone (7.5 mg), flunitrazepam (1 mg) or a placebo. The results show no residual effects of the molecules. Only flunitrazepam, a benzodiazepine with a long half-life, appears to cause subjects to focus their attention on an element which, while relevant for the task (a road sign playing the role of a spatial reference), is not used correctly.
mesh_terms: D000063:Accidents, Traffic / Q000523:psychology*; D000328:Adult; D001288:Attention / Q000187:drug effects; D001334:Automobile Driving / Q000523:psychology*; D053961:Azabicyclo Compounds; D005260:Female; D005445:Flunitrazepam / Q000009:adverse effects* / Q000493:pharmacokinetics; D006207:Half-Life; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects* / Q000493:pharmacokinetics; D008297:Male; D010879:Piperazines / Q000009:adverse effects* / Q000493:pharmacokinetics; D011725:Pyridines / Q000009:adverse effects* / Q000493:pharmacokinetics; D013647:Task Performance and Analysis; D013997:Time Factors; D000077334:Zolpidem
chemical_list: D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; D011725:Pyridines; C515050:zopiclone; D005445:Flunitrazepam; D000077334:Zolpidem