Does treatment with clean intermittent catheterization in boys with posterior urethral valves affect bladder and renal function?
OBJECTIVE
In boys with resected posterior urethral valves (PUV) deterioration of renal function is seen during childhood and adolescence, which may partly be caused by bladder dysfunction. We present data on renal and bladder function initially and at followup of boys with PUV in whom the bladder dysfunction has been treated since infancy.


METHODS
The study included 35 boys with PUV. Bladder regimen, including early toilet training from the age of 1.5 years and detrusor relaxant drugs for the treatment of incontinence from ages 4 to 6 years, was introduced to all patients. A total of 19 boys were started on clean intermittent catheterization (CIC) at a median age of 8 months due to pronounced bladder dysfunction with poor emptying, unsafe pressure levels, high grade reflux and renal impairment.


RESULTS
No serious complications of CIC have been seen during followup. Of the 19 boys 2 stopped performing CIC due to noncompliance of the parents at 1 and 3 years, respectively. Initial renal function, measured as median glomerular filtration rate (GFR) in percent of expected for age, was 60% in the CIC group and 90% in the nonCIC group. At followup at a median age of 8 years the CIC group (n = 14, 3 transplanted boys excluded) had an increase in median differential GFR (difference between followup and initial GFR) of 7% (p <0.01), which was similar increase to that of the nonCIC group. In the 2 boys who stopped performing CIC renal function deteriorated with a median differential GFR of -24%. In the CIC group detrusor instability decreased. Poor compliance was seen in 6 of the 19 boys initially and only one remained poorly compliant. In 1 of the boys who stopped performing catheterization a low compliant bladder developed. In all of the other cases bladder capacity increased more than expected for age.


CONCLUSIONS
The results suggest that treatment of bladder dysfunction in boys with PUV can counteract the deterioration in renal function seen during childhood but the number of patients in our study is limited.
D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007674:Kidney Diseases / Q000503:physiopathology / Q000628:therapy*; D007677:Kidney Function Tests; D008297:Male; D012189:Retrospective Studies; D014524:Urethral Obstruction / Q000151:congenital* / Q000628:therapy; D001743:Urinary Bladder / Q000502:physiology; D014546:Urinary Catheterization; D014549:Urinary Incontinence / Q000503:physiopathology / Q000628:therapy*; D014555:Urination Disorders / Q000503:physiopathology / Q000628:therapy*; D014563:Urodynamics / Q000502:physiology; D014567:Urography; D014718:Vesico-Ureteral Reflux / Q000503:physiopathology / Q000628:therapy*