[Transfusion of plasma of endotoxin tolerant rats improves survival of hemorrhagic shock in the rat model].
To evaluate the protective effect of endotoxin tolerant plasma after hemorrhagic shock, plasma of endotoxin tolerant animals was used for resuscitation of normal rats. The transfusion of plasma of endotoxin tolerant rats improved the survival rate from 20 to 60 per cent. In the sera of endotoxin tolerant animals a TNF inhibitory activity was detected, which could be transferred by the plasma. This effect may be responsible for the protection to hemorrhagic shock.
D000818:Animals; D004731:Endotoxins / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology*; D007108:Immune Tolerance / Q000276:immunology*; D007116:Immunization, Passive / Q000379:methods*; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D009102:Multiple Organ Failure / Q000276:immunology / Q000401:mortality; D010949:Plasma / Q000276:immunology*; D010951:Plasma Exchange; D051381:Rats; D017207:Rats, Sprague-Dawley; D012771:Shock, Hemorrhagic / Q000276:immunology* / Q000401:mortality; D015996:Survival Rate; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
D004731:Endotoxins; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha