title: Treatment of spasticity in a spinal cord-injured patient with intrathecal morphine due to intrathecal baclofen tolerance--a case report and review of literature.
abstract: METHODS
  Case report.
  
  
  OBJECTIVE
  To report treatment of spasticity in a spinal cord-injured person with intrathecal morphine after the person developed tolerance to intrathecal baclofen.
  
  
  METHODS
  Spasticity in a 36-year-old man with T6 complete paraplegia was treated with increasing doses of intrathecal baclofen. When he developed tolerance to intrathecal baclofen, he was given continuous infusion of morphine intrathecally.
  
  
  METHODS
  Regional Spinal Injuries Centre, UK.
  
  
  RESULTS
  Spasticity was adequately controlled by intrathecal morphine.
  
  
  CONCLUSIONS
  In spinal cord-injured patients with severe spasticity, who become tolerant to intrathecal baclofen, treatment with intrathecal morphine may be useful.
mesh_terms: D000328:Adult; D001418:Baclofen / Q000008:administration & dosage / Q000627:therapeutic use; D004361:Drug Tolerance; D006801:Humans; D015918:Infusion Pumps, Implantable; D007278:Injections, Spinal; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000627:therapeutic use*; D009125:Muscle Relaxants, Central / Q000008:administration & dosage / Q000627:therapeutic use; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000209:etiology; D009294:Narcotics / Q000008:administration & dosage / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000150:complications* / Q000503:physiopathology
chemical_list: D009125:Muscle Relaxants, Central; D009294:Narcotics; D009020:Morphine; D001418:Baclofen