title: Synthesis and hypnotic-sedative activities of N-substituted uracil on mice.
abstract: N3-Phenacyl-N1-substituted uracils 3a-q were synthesized by introduction of substituents at the N1-position of N3-phenacyluracil 2, and their hypnotic and sedative activities were evaluated. Pharmacological activities of these N3-phenacyl-N1-substituted uracils were examined using hypnotic activity and synergistic effects with pentobarbital or diazepam for the hypnotic and sedative activities.
mesh_terms: D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D004357:Drug Synergism; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D010424:Pentobarbital / Q000494:pharmacology; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D006993:Hypnotics and Sedatives; D014498:Uracil; D010424:Pentobarbital; D003975:Diazepam