[Liposome encapsulation of cystostatic drugs and starch microspheres improve tumor targeting in locoregional therapy. An animal experiment study of CC 531 liver tumor].
Systemic adjuvant chemotherapy achieves unsatisfactory results for inoperable liver tumors and metastases. Various clinical studies have shown that locoregional chemotherapy increased the survival rate by a few months. The aim of this study was to investigate tumor targeting of the most frequently used cytostatic 5-fluouracil by modifying systemic and locoregional therapy by liposome encapsulation. The tumor concentration of 5-FU encapsulated in SUV-PEG liposomes increases by a factor of 27 in systemic therapy and a factor of 90 in locoregional therapy. The tumor concentration of 5-FU increases by a factor of 8000, if the blood flow is additionally slowed by starch microspheres (Spherex) during locoregional therapy with liposome-encapsulated 5-FU.
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016503:Drug Delivery Systems / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D005472:Fluorouracil / Q000494:pharmacology*; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial / Q000379:methods*; D008081:Liposomes; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D008279:Magnetic Resonance Imaging; D009368:Neoplasm Transplantation / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013213:Starch; D014407:Tumor Cells, Cultured / Q000473:pathology
D000964:Antimetabolites, Antineoplastic; D008081:Liposomes; C044817:Spherex; D013213:Starch; D005472:Fluorouracil