Efficient protocol for ring opening of spiroketals using trifluoroacetyl trifluoromethanesulfonate (TFAT).
[reaction: see text] Ring opening of steroidal spiroketals under exceptionally mild conditions is smoothly achieved via reaction with trifluoroacetyl trifluoromethanesulfonate (TFAT). The new spiroketal ring-opening protocol provides omega-trifluoroacetyl vinyl ethers in good yield and avoids difficulties that attended previously employed vigorous reaction conditions.
D007659:Ketones / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry*
D007659:Ketones; D008698:Mesylates; D013141:Spiro Compounds; D013256:Steroids; C012077:trifluoromethanesulfonic acid