title: Methods for evaluating the duration of action of once-daily antihypertensive therapy.
abstract: There are several methods available to determine the duration of action of an antihypertensive drug. Traditional approaches involve measurements of blood pressure (BP) at the end of the dosing interval (trough). Ambulatory BP monitoring can be used to obtain additional information on the time course and magnitude of the decrease in BP over a standard dosing interval. Use of the 'missed dose' technique makes it possible to demonstrate persistent reductions in BP beyond 24 h for drugs given on a once-daily basis.
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D018660:Blood Pressure Monitoring, Ambulatory; D004334:Drug Administration Schedule; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D008722:Methods; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents