[Mini-transplant from a matched unrelated donor].
It is also important to establish a method to use alternative donors in mini-transplant settings. However, there are some problems, such as difficulty in performing donor-lymphocyte infusion(DLI) from an unrelated donor. In most countries including Japan, bone marrow is mostly used as a source of stem cells in unrelated transplant. This may cause another problem in engraftment. In addition, graft rejection and GVHD may also be a problem because of the difference in minor antigens. Despite these problems, early experience including our own has shown that mini-transplant from an unrelated donor is a feasible procedure and further development is expected.
D006084:Graft Rejection / Q000209:etiology; D006086:Graft vs Host Disease / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation; D006648:Histocompatibility; D006801:Humans; D015778:Minor Histocompatibility Antigens; D014019:Tissue Donors
D015778:Minor Histocompatibility Antigens