Pyrimido[1,2-b]-1,2,4,5-tetrazin-6-ones as HCMV protease inhibitors: a new class of heterocycles with flavin-like redox properties.
The synthesis and biological activity of pyrimidotetrazin-6-ones against HCMV protease is described. The mechanism of action for these inhibitors is the oxidation of several cysteine residues to generate cross-linked enzyme.
D003587:Cytomegalovirus / Q000201:enzymology*; D010450:Endopeptidases / Q000187:drug effects* / Q000378:metabolism; D005415:Flavins / Q000737:chemistry*; D010084:Oxidation-Reduction; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology*
D005415:Flavins; D011480:Protease Inhibitors; D011743:Pyrimidines; D010450:Endopeptidases