[Liver pathology in patients with primary hemochromatosis--homozygous carriers of C282Y mutation ].
Liver pathology was studied in 3 patients with primary chemochromatosis. In two cases so-called iron free foci with signs of hepatocytes with feature of dysplasia were found. Many siderosomes were found ultrastructurally in the cytoplasma of hepatocytes. Histological markers of virus infection were absent in a patient with positive serum HbsAg and HCV-Ab. Alcohol did not produce typical histological changes. In this case grave liver reticuloendothelial hemosiderosis typical for secondary hemochromatosis and overloading with iron of spleen pulp according to MR imaging were observed.
D005819:Genetic Markers / Q000235:genetics; D006432:Hemochromatosis / Q000235:genetics / Q000473:pathology*; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000473:pathology* / Q000648:ultrastructure; D008279:Magnetic Resonance Imaging; D008565:Membrane Proteins / Q000235:genetics*; D008854:Microscopy, Electron; D008875:Middle Aged; D009154:Mutation
D005819:Genetic Markers; C103673:HFE protein, human; D000071020:Hemochromatosis Protein; D015395:Histocompatibility Antigens Class I; D008565:Membrane Proteins