Inflammatory cytokine production predominates in early Lyme disease in patients with erythema migrans.
In a study of cytokine production ex vivo by Borrelia burgdorferi-stimulated peripheral blood mononuclear cells from 27 patients with culture-positive erythema migrans, production of inflammatory cytokines predominated, particularly gamma interferon and, to a lesser degree, tumor necrosis factor alpha. In contrast, with the exception of interleukin-13, anti-inflammatory cytokine production was negligible. Thus, B. burgdorferi antigens in early Lyme disease often induce a strong inflammatory response.
D000942:Antigens, Bacterial / Q000008:administration & dosage; D000954:Antigens, Surface / Q000008:administration & dosage / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000008:administration & dosage / Q000276:immunology; D001428:Bacterial Vaccines; D025065:Borrelia burgdorferi / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis*; D015787:Erythema Chronicum Migrans / Q000276:immunology*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D018836:Inflammation Mediators / Q000378:metabolism*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008074:Lipoproteins; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology
D000942:Antigens, Bacterial; D000954:Antigens, Surface; D001425:Bacterial Outer Membrane Proteins; D001428:Bacterial Vaccines; D016207:Cytokines; D018836:Inflammation Mediators; D008074:Lipoproteins; C072045:OspA protein; C079616:OspC protein