In vitro interaction of flucytosine with conventional and new antifungals against Cryptococcus neoformans clinical isolates.
Combinations of flucytosine with conventional and new antifungals were evaluated in vitro against 30 clinical isolates of Cryptococcus neoformans. Synergy determined by checkerboard analysis was observed with combinations of fluconazole, itraconazole, voriconazole, amphotericin B, and caspofungin with flucytosine against 77, 60, 80, 77, and 67% of the isolates, respectively. Antagonism was never observed. Killing curves showed indifferent interactions between triazoles and flucytosine and synergy between amphotericin B and flucytosine.
D000935:Antifungal Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D003455:Cryptococcus neoformans / Q000187:drug effects*; D004347:Drug Interactions; D004357:Drug Synergism; D005437:Flucytosine / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data
D000935:Antifungal Agents; D005437:Flucytosine