title: T(11;18)(q21;q21) in gastric MALT lymphoma and diffuse large B-cell lymphoma of Chinese patients.
abstract: T(11;18)(q21;q21) occurs at variable frequencies in mucosa-associated lymphoid tissue (MALT) lymphomas of different sites. In gastric MALT lymphoma, it occurs in 30% cases and the translocation positive tumours are frequently at advanced stages and do not respond to Helicobacter pylori eradication. Intriguingly, t(11;18)(q21;q21) has been observed only rarely in mucosal diffuse large B-cell lymphomas (DLBCL), despite that at least a proportion of these tumours are believed to be the result of transformation of an MALT lymphoma. We previously examined t(11;18)(q21;q21) in gastric MALT lymphoma of Chinese in Taiwan and found the translocation in one of the three transformed MALT lymphomas studied. To extend this observation, we have examined t(11;18)(q21;q21) in a large cohort of gastric lymphomas of Chinese in China including 39 MALT lymphomas (12 with high-grade components) and 53 DLBCL by reverse transcription and PCR. Of these cases, RNA samples extracted from 36 MALT lymphomas including 10 cases with high-grade component and 46 DLBCL were adequate for detection of the translocation as judged by control RT-PCR of a house-keeping gene. T(11;18)(q21;q21) was found in 8/36 (22%) MALT lymphomas and 1/46 (2%) DLBCL. None of the MALT lymphoma with high-grade component showed t(11;18)(q21;q21). Our results suggest that t(11;18)(q21;q21) occurs only occasionally in transformed MALT lymphoma.
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; D002352:Carrier Proteins / Q000032:analysis; D002880:Chromosomes, Human, Pair 11; D002887:Chromosomes, Human, Pair 18; D006801:Humans; D016393:Lymphoma, B-Cell / Q000453:epidemiology / Q000235:genetics; D018442:Lymphoma, B-Cell, Marginal Zone / Q000453:epidemiology / Q000235:genetics*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000453:epidemiology / Q000235:genetics*; D017720:Molecular Epidemiology; D015514:Oncogene Proteins, Fusion / Q000032:analysis / Q000235:genetics; D012334:RNA, Neoplasm / Q000032:analysis; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000235:genetics*; D013624:Taiwan / Q000453:epidemiology; D014178:Translocation, Genetic
chemical_list: C415943:API2-MALT1 fusion protein, human; D048868:Adaptor Proteins, Signal Transducing; D000074018:B-Cell CLL-Lymphoma 10 Protein; C118591:BCL10 protein, human; D002352:Carrier Proteins; D015514:Oncogene Proteins, Fusion; D012334:RNA, Neoplasm