[The difficulty of obtaining immunologic responses in mucosae. Use of coadjuvants].
The search of immunogenicity represents a real problem to be solved with the new techniques to vaccines design. Despite of numerous initiatives to increase the immune response at mucosal sites, there are few substances available to exert an adequate immunogenicity in mucosal compartments. On this hand the research on mucosal adjuvants has arise interest. Mechanism of both: immunogenicity and adjuvanticity, were reviewed putting emphasis mainly in two mucosal adjuvants, cholera toxin and the protoxin Cry1Ac from Bacillus thuringiensis.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001413:Bacillus thuringiensis / Q000276:immunology; D000083722:Bacillus thuringiensis Toxins; D001426:Bacterial Proteins / Q000008:administration & dosage / Q000276:immunology* / Q000494:pharmacology; D001427:Bacterial Toxins; D002772:Cholera Toxin / Q000008:administration & dosage / Q000276:immunology* / Q000494:pharmacology; D004731:Endotoxins / Q000008:administration & dosage / Q000276:immunology* / Q000494:pharmacology; D006460:Hemolysin Proteins; D006801:Humans; D018928:Immunity, Mucosal / Q000187:drug effects*; D008322:Mammals / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D014611:Vaccination / Q000379:methods
D000276:Adjuvants, Immunologic; D000083722:Bacillus thuringiensis Toxins; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D004731:Endotoxins; D006460:Hemolysin Proteins; C030956:insecticidal crystal protein, Bacillus Thuringiensis; D002772:Cholera Toxin