title: Stereotactic biopsies of focal brainstem lesions.
abstract: BACKGROUND
  Stereotactic biopsies of the brainstem (SBB) are a selected group of stereotactic operations owing to the lower incidence of brainstem lesions requiring biopsy, the greater complexity, and the higher risks of these procedures. Usually, the lower the lesion in the brainstem, the greater the risks involved. The approach of the different target locations by distinct routes, transcerebral and transcerebellar, is still a matter of debate. Moreover, pure medullary lesions are seldom biopsied, whereas diffuse brainstem lesions, typical of children's brainstem gliomas and rather frequent in most published series, depend less and less on the histopathological confirmation for treatment. In this study, the authors present their own experience on SBB aiming to discuss mainly their indications, approach routes choice, and procedure techniques.
  
  
  METHODS
  The authors reviewed a series of 30 SBB (27 adults and 3 children) out of 450 stereotactic biopsies of the central nervous system performed for the last 10 years. All cases but one presented as focal brainstem masses, 19 mainly in the pons and 10 in the midbrain. Eleven lesions (10 in the midbrain and one midbrain-pontine) were approached by a transfrontal route. All the others were approached by a suboccipital transcerebellar route.
  
  
  RESULTS
  Twenty-six (87%) out of the 28 cases (93%) where a positive histopathological result was obtained had a specific diagnosis: 18 tumors (14 astrocytomas, 2 primary brain lymphomas, 1 oligodendroglioma, and 1 ganglioglioma), 2 toxoplasmosis, 2 sarcoidosis, 1 aspergillus abscess, 1 vasculitis, 1 acute inflammatory demyelinating disease, and 1 progressive multifocal leucoencephalopathy. Four nontumoral lesions arose in patients with AIDS. Morbidity was restricted to 2 cases consisting of transient cranial nerve deficits.
  
  
  CONCLUSIONS
  Stereotactic biopsies are specially useful for the diagnosis of focal brainstem lesions. Midbrain and midline lesions should be approached through the cerebrum, whereas most of the pontine lesions through the cerebellum. Overall, this procedure should be performed with "functional-like" precision and require some technical refinements to reach maximal accuracy with minimal morbidity.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods*; D001927:Brain Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000601:surgery*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000601:surgery; D001933:Brain Stem / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013238:Stereotaxic Techniques; D014057:Tomography, X-Ray Computed