title: In vitro immunomodulating influence of methisoprinol on the head kidney phagocyte and lymphocyte activity after suppression induced by VHSV in rainbow trout (Oncorhynchus mykiss).
abstract: The aim of this study was to evaluate the in vitro influence of methisoprinol on head kidney phagocyte and lymphocyte activity after suppression induced by VHSV. The VHSV statistically significantly decreased the respiratory burst activity of head kidney phagocytes and the proliferative response of lymphocytes stimulated by ConA. The results of our study showed that methisoprinol at a concentration of 100 microl/ml modulated and restored the phagocyte and lymphocyte activity suppressed by VHSV.
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D005393:Fish Diseases / Q000276:immunology* / Q000821:virology; D007542:Inosine Pranobex / Q000008:administration & dosage / Q000494:pharmacology*; D007668:Kidney / Q000166:cytology / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D029141:Novirhabdovirus / Q000472:pathogenicity; D017686:Oncorhynchus mykiss; D010587:Phagocytosis / Q000187:drug effects; D018353:Rhabdoviridae Infections / Q000276:immunology / Q000662:veterinary*
chemical_list: D000276:Adjuvants, Immunologic; D007542:Inosine Pranobex