[Characterization of spontaneous transplant tolerance exemplified by orthotopic liver transplantation: significance of Fas ligand induced programmed cell death].
For the first time, this study provides strong evidence that hepatocytes express functional Fas-ligand protein after orthotopic liver transplantation in specific allogeneic strain combinations. Fas-L expression correlates with intra-graft elimination of alloreactive T cells and subsequent tolerance induction. Thus, detection of Fas-L offers the possibility to be used as a marker protein for tolerized liver transplants.
D000818:Animals; D017209:Apoptosis / Q000276:immunology; D053222:Fas Ligand Protein; D015870:Gene Expression / Q000502:physiology; D022781:Hepatocytes / Q000276:immunology; D020287:In Situ Nick-End Labeling; D016031:Liver Transplantation / Q000276:immunology*; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000276:immunology; D023001:Transplantation Tolerance / Q000276:immunology*
D053222:Fas Ligand Protein; C505662:Faslg protein, rat; D008562:Membrane Glycoproteins