title: Autopsy verifies demyelination and lack of vascular damage in partially reversible radiation myelopathy.
abstract: METHODS
  Case report of recovering radiation myelopathy.
  
  
  OBJECTIVE
  To present autopsy and functional imaging findings on a unique case of slowly recovering radiation myelopathy with the aim of the clarification of the underlying mechanism.
  
  
  METHODS
  The cervical spinal cord and the distal part of the medulla oblongata of a 36-year-old thyroid cancer patient had been incorrectly irradiated with a total dose of 61 Gy and a fraction size of 3.4 Gy (J Neurol Sci 1999; 163:39-43), resulting in incomplete cervical transection with a 5-month latency period following the termination of radiotherapy. This was followed by a 9.5-year spontaneous improvement until her demise, during which the check-ups were supplemented by positron emission tomography (PET) investigations; these indicated increased [18F]deoxyglucose and [15O]butanol uptakes, but a diminished [11C]methionine accumulation by the irradiated spinal cord segment.
  
  
  RESULTS
  Autopsy revealed demyelination (with axonal loss) and neuronal damage in the cervical spinal cord and the distal part of the medulla oblongata. In the same region, only minimal vascular injury (thickening of some of the capillary walls) was detected, but not cell proliferation or chronic inflammation. Bilateral, secondary pyramidal tract degeneration caudal to the irradiated segment was observed. The PET and autopsy findings, although separated by 2 years, are consistent.
  
  
  CONCLUSIONS
  The pathological state of the spinal cord revealed by the autopsy is concordant with the incomplete cervical transection, implying that the functional recovery is supported by a process that probably differs from the restoration of the mechanism destroyed by the radiotherapy. For the restoration of the function, we suggest an altered conduction mechanism of the action potential, involving an increased number of sodium channels along the demyelinated segments of the injured axons, which is fully congruent with the PET findings.
mesh_terms: D000328:Adult; D001344:Autopsy; D001808:Blood Vessels / Q000528:radiation effects*; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging / Q000528:radiation effects; D003711:Demyelinating Diseases / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D017809:Fatal Outcome; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D008526:Medulla Oblongata / Q000000981:diagnostic imaging / Q000473:pathology / Q000528:radiation effects; D008581:Meningitis / Q000150:complications; D008715:Methionine / Q000493:pharmacokinetics; D009410:Nerve Degeneration / Q000209:etiology / Q000473:pathology; D009474:Neurons / Q000473:pathology; D010104:Oxygen Radioisotopes / Q000493:pharmacokinetics; D010264:Paraplegia / Q000209:etiology; D011832:Radiation Injuries / Q000150:complications; D011859:Radiography; D011878:Radiotherapy / Q000009:adverse effects*; D013116:Spinal Cord / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D013118:Spinal Cord Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D013964:Thyroid Neoplasms / Q000532:radiotherapy; D014055:Tomography, Emission-Computed
chemical_list: D010104:Oxygen Radioisotopes; D019788:Fluorodeoxyglucose F18; D008715:Methionine