[Selective bradykinin B1 receptor block in ischemia/reperfusion of the rat pancreas].
The selective bradykinin B1-receptor-antagonist CP-0298 reduces ischemia/reperfusion induced enhanced leukocyte adherence in postcapillary venules of the pancreas, but has no influence on the microvascular perfusion failure. The postischemic enzyme release will effectively attenuated by the antagonist. Wether the activation of the B1-receptor under pathophysiological conditions exerts protective effects to maintain the integrity of the pancreas, has to be evaluated in further experiments.
D000208:Acute Disease; D000818:Animals; D065168:Bradykinin Receptor Antagonists; D008833:Microcirculation / Q000187:drug effects / Q000503:physiopathology; D008856:Microscopy, Fluorescence; D010179:Pancreas / Q000098:blood supply*; D010195:Pancreatitis / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D043783:Receptor, Bradykinin B1; D018002:Receptors, Bradykinin / Q000502:physiology; D015427:Reperfusion Injury / Q000503:physiopathology*
D065168:Bradykinin Receptor Antagonists; D043783:Receptor, Bradykinin B1; D018002:Receptors, Bradykinin