Insulin-induced iron loading in the rat brown adipose tissue: histochemical and electron-microscopic study.
In the present study we have reported an iron-loading in the rat brown adipose tissue (BAT) after 3-day treatment with insulin (4 IU/kg). Light microscopy showed numerous iron-positive cells (Perls' stain) mainly macrophages and brown adipocytes, while electron-microscopic examination revealed lipofuscin granules and phagosomes as iron-containing components. These results clearly indicate that iron participates in damaging of brown adipocytes.
D002001:Adipose Tissue, Brown / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D000818:Animals; D007328:Insulin / Q000494:pharmacology*; D007501:Iron / Q000378:metabolism*; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D017208:Rats, Wistar
D007328:Insulin; D007501:Iron