title: Vaccination against poliomyelitis in Poland with types 1 and 3 attenuated viruses of Koprowski. 1. Virological studies of the vaccine strains and serological studies of the vaccinated population.
abstract: Mass vaccination of the juvenile population with live poliovirus vaccine was carried out in Poland in 1959 and 1960. In all, some 7 239 000 children 6 months to 14 years old were given type 1 (CHAT) virus, and nearly 6 818 500 children of the same age-group received type 3 (W-Fox) virus.A serological conversion rate (from <1:4 to >/=1:4) of 91.7% was achieved with type 1 and of 91.0% with type 3-a satisfactory demonstration of the immunogenicity of the strains used. Although type 2 virus was not administered, seroconversion with this type occurred in 65.4%. This may have been caused by antigenic elements common to the three poliovirus types, and previous vaccination with Salk vaccine may also have been a contributory factor.The authors conclude that the mass vaccination described in this paper has created a highly immune population in Poland.
mesh_terms: D000293:Adolescent; D002648:Child; D006801:Humans; D032541:Mass Vaccination; D011044:Poland; D011051:Poliomyelitis / Q000276:immunology*; D017955:Poliovirus; D011054:Poliovirus Vaccine, Inactivated; D014611:Vaccination
chemical_list: D011054:Poliovirus Vaccine, Inactivated
keywords: POLIOMYELITIS/immunology; VACCINATION