title: Features of skin-coincubated macrophages that promote recovery from spinal cord injury.
abstract: Uncontrolled inflammation is considered to exacerbate the neuronal loss that follows spinal cord trauma. However, controlled inflammation response appears to be beneficial. Skin-coincubated macrophages injected into contused spinal cord of rats resulted in improved motor recovery and reduced spinal cyst formation. The macrophages express elevated levels of cell-surface molecules CD80, CD86, CD54 and MHC-II, markers characteristic of antigen presenting cells (APCs). Additionally, skin-coincubation elevates secretion of interleukin-1 beta (IL-1 beta) and Brain-Derived Neurotrophic Factor (BDNF), and reduces secretion of tumor necrosis factor alpha (TNF-alpha). We propose that macrophages activated by skin-coincubation bolster neuroprotective immune activity in the spinal cord, making the environment less cytotoxic and less hostile to axonal regeneration.
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism / Q000637:transplantation; D001522:Behavior, Animal; D016207:Cytokines / Q000378:metabolism; D015552:Injections, Intralesional; D008262:Macrophage Activation / Q000276:immunology; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism / Q000637:transplantation; D008297:Male; D009043:Motor Activity / Q000276:immunology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000276:immunology*; D013119:Spinal Cord Injuries / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*
chemical_list: D016207:Cytokines