[What is the function of neutrophilic granulocytes in microcirculatory disorders in free tissue transfer?].
In a free flap model capillary perfusion in the downstream tissue, i.e. the flap is significantly decreased after one hour of ischemia. This decrease occurs even though circulating PMN's have been depleted and are not available to mediate this phenomenon. It is suggested that PMN's do not mediate the mechanism responsible for reduced capillary perfusion and possible microvascular failure.
D000818:Animals; D007511:Ischemia / Q000276:immunology / Q000503:physiopathology; D008297:Male; D008833:Microcirculation / Q000503:physiopathology; D008866:Microsurgery; D009504:Neutrophils / Q000276:immunology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000502:physiology; D013524:Surgical Flaps / Q000098:blood supply*