[Differential modulation of CINC, NOSII and ICAM- gene expression in parenchyma and non-parenchyma cells of the liver by G-CSF--possible protective mechanisms of endotoxin-associated hepatotoxicity].
In endotoxin-exposed rat livers, G-CSF caused a reduction of CINC gene transcripts in the nonparenchymal cell fraction, which might be the mechanism for attenuation of microvascular leukocyte adherence and leukocyte-dependent tissue injury, as observed upon G-CSF application in a model of endotoxin-induced hepatotoxicity.
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects / Q000276:immunology; D056486:Chemical and Drug Induced Liver Injury / Q000276:immunology*; D018925:Chemokines / Q000235:genetics*; D019743:Chemokines, CXC; D002630:Chemotactic Factors / Q000235:genetics*; D019610:Cytoprotection / Q000276:immunology*; D004730:Endothelium, Vascular / Q000276:immunology; D019446:Endotoxemia / Q000276:immunology*; D015870:Gene Expression / Q000187:drug effects; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D022781:Hepatocytes / Q000187:drug effects / Q000276:immunology; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology; D008099:Liver / Q000098:blood supply* / Q000276:immunology; D008297:Male; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052247:Nitric Oxide Synthase Type II; D051381:Rats; D017207:Rats, Sprague-Dawley
D018925:Chemokines; D019743:Chemokines, CXC; D002630:Chemotactic Factors; D036341:Intercellular Signaling Peptides and Proteins; D018799:Intercellular Adhesion Molecule-1; D016179:Granulocyte Colony-Stimulating Factor; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II