title: [Graft versus host disease and cytokines].
abstract: Allogeneic hematopoietic stem cell transplantation(Allo-HSCT) is a standard therapy for hematological malignancies. However, graft versus host disease(GVHD) remains one of the major obstacles for successful Allo-HSCT. The insight into the pathogenesis of GVHD has been profoundly improved by recent advances in our understanding of the immune system and progress of the molecular biology. A primary causes for GVHD are the inappropriate production of cytokines and dysregulation of complex cytokine network occurs in the three sequential steps: conditioning regimen, donor T cell activation and effector mechanisms. This short review discusses the interaction between the cytokines and the cellular effector of GVHD in each step.
mesh_terms: D000938:Antigen-Presenting Cells / Q000276:immunology; D016207:Cytokines / Q000502:physiology*; D006086:Graft vs Host Disease / Q000209:etiology*; D019337:Hematologic Neoplasms / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
chemical_list: D016207:Cytokines