Priming virulence factors for delivery into the host.
Several medically important Gram-negative bacterial pathogens inject virulence factors into host cells through a type III secretion system and specialized bacterial chaperones are required for their effective delivery. Recent structural work shows that these chaperones maintain virulence factors in a partially non-globular conformation that is primed for unfolding and translocation through the 'injectisome'.
D000818:Animals; D006090:Gram-Negative Bacteria / Q000472:pathogenicity*; D006801:Humans; D018832:Molecular Chaperones / Q000378:metabolism*; D037521:Virulence Factors / Q000378:metabolism*
D018832:Molecular Chaperones; D037521:Virulence Factors