title: A closer view of tissue engineering in China: the experience of tissue construction in immunocompetent animals.
abstract: Tissue engineering started in late 1980s and is now well established and progressing rapidly in Western developed countries. However, the development of tissue-engineering research in China remains relatively unknown to the international society of tissue engineering. Although involved in all areas of tissue-engineering research, including the creation of new scaffold materials, in vitro studies of seed cells, application of growth factors, and modification of seed cells and scaffold materials, China has put special emphasis on tissue construction in large mammalian animals in order to establish a solid scientific basis for clinical application of engineered tissues. To provide a closer view of tissue-engineering research in China, this article reviews our experience in tissue construction and tissue repair using immunocompetent animals such as sheep, pig, and dog as well as hen and rabbit. The engineered tissues include bone, cartilage, tendon, skin, blood vessels, cornea, and peripheral nerves.
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology; D018786:Bone Substitutes; D002356:Cartilage / Q000502:physiology; D002681:China; D007121:Immunocompetence / Q000276:immunology / Q000502:physiology; D012756:Sheep; D013234:Stem Cells / Q000502:physiology; D023822:Tissue Engineering
chemical_list: D018786:Bone Substitutes