Myeloid marker expression on antiviral CD8+ T cells following an acute virus infection.
CD11b, CD11c, and F4/80 are normally used to define dendritic cell and/or macrophage populations. In this study, the expression of all three markers was observed on CD8(+) T cells following infection of mice with several distinct viruses. Using lymphocytic choriomeningitis virus as a model virus, it was found that relatively more CD11b(+)CD8(+) and CD11c(+)CD8(+) T cells were present in the periphery than in primary lymphoid organs; in contrast, the F4/80(+)CD8(+) T cell population was more prevalent in the spleen. All three myeloid markers were detected on virus-specific CTL. The expression of CD11b and CD11c on CD8(+) T cells correlated with their level of CTL activity, whereas the F4/80(+)CD8(+) T cell population increased after the peak of the CTL response but did not have higher CTL activity. These data suggest that there is a differential induction of CD11b, CD11c, and F4/80 on virus-specific CD8(+) T cells following an acute virus infection.
D000208:Acute Disease; D000818:Animals; D000943:Antigens, Differentiation / Q000032:analysis*; D039481:CD11b Antigen / Q000032:analysis*; D039521:CD11c Antigen / Q000032:analysis*; D018414:CD8-Positive T-Lymphocytes / Q000737:chemistry*; D005260:Female; D008216:Lymphocytic Choriomeningitis / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013602:T-Lymphocytes, Cytotoxic / Q000737:chemistry
D000943:Antigens, Differentiation; D039481:CD11b Antigen; D039521:CD11c Antigen; C036763:monocyte-macrophage differentiation antigen