[Cerebrospinal fluid filtration as experimental therapy in therapy refractory psychoses in Borna disease virus seropositive patients. Therapeutic effects, findings].
According to previous investigations, mild Borna disease virus encephalitis may underlie a subgroup of affective or schizophrenic type psychoses. And virus-induced immune pathology may underlie even a larger subgroup of psychoses. We treated BDV seropositive patients suffering from therapy resistant schizophrenic or affective spectrum psychoses by cerebrospinal fluid filtration (CSFF) in an experimental add-on treatment. CSFF was shown previously to be an effective immune modulatory treatment in autoimmune neurological disease, Guillain-Barré syndrome. CSFF appears to be an effective treatment in therapy resistant psychosis also, but only 4 patients were treated yet.
D000914:Antibodies, Viral / Q000134:cerebrospinal fluid*; D001890:Borna Disease / Q000134:cerebrospinal fluid / Q000276:immunology / Q000628:therapy* / Q000821:virology; D001891:Borna disease virus / Q000276:immunology; D002555:Cerebrospinal Fluid / Q000276:immunology / Q000821:virology*; D003131:Combined Modality Therapy; D006801:Humans; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000134:cerebrospinal fluid / Q000276:immunology / Q000628:therapy* / Q000821:virology; D012559:Schizophrenia / Q000134:cerebrospinal fluid / Q000276:immunology / Q000628:therapy* / Q000821:virology; D016060:Sorption Detoxification; D013129:Spinal Puncture; D014462:Ultrafiltration
D000914:Antibodies, Viral