Labyrinthectomy changes T-type calcium channels in vestibular neurones of the guinea pig.
In the vestibular nuclei of the awake guinea pig, all neurones are spontaneously active. After unilateral labyrinthectomy, this activity virtually disappears on the ipsilateral side, but is completely restored one week later. In a recent study, we observed that the restoration of spontaneous activity was correlated with an increase in pacemaker activity. In the current study, we found that the ratio of medial vestibular nucleus (MVN) neurones endowed with one of the currents known to play a role in pacemaker activity (i.e. low-threshold calcium current; LTCC) increased from 29% in control guinea pigs to 65% in animals labyrinthectomised on the ipsilateral side one week earlier. Yet this change was not correlated with a modification of the ratio of neurones expressing any of the three related protein-channels (alpha1G, alpha1H and alpha1I).
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D020747:Calcium Channels, T-Type / Q000096:biosynthesis* / Q000378:metabolism / Q000502:physiology; D007758:Ear, Inner / Q000502:physiology* / Q000601:surgery*; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D014725:Vestibular Nerve / Q000502:physiology*
D020747:Calcium Channels, T-Type