lunatic fringe regulates Delta-Notch induction of hypochord in zebrafish.
Cells that occupy the midline of vertebrate embryos arise from a common population of precursors. Several lines of evidence indicate that Delta-Notch signaling regulates specification of midline precursors for different fates. We show that zebrafish midline precursors transiently express lunatic fringe, which encodes a glycosyltransferase that modifies Notch activity in response to its ligands, and that lunatic fringe function is required for Delta-Notch-mediated induction of hypochord cells at the lateral borders of the midline precursor domain.
D000818:Animals; D019521:Body Patterning; D003001:Cloning, Molecular; D005775:Gastrula; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects*; D016695:Glycosyltransferases / Q000235:genetics / Q000378:metabolism*; D017403:In Situ Hybridization; D047908:Intracellular Signaling Peptides and Proteins; D008024:Ligands; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D009672:Notochord / Q000502:physiology*; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D051880:Receptors, Notch; D015398:Signal Transduction; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics*; D029961:Zebrafish Proteins / Q000502:physiology
D047908:Intracellular Signaling Peptides and Proteins; D008024:Ligands; D008565:Membrane Proteins; D016376:Oligonucleotides, Antisense; D051880:Receptors, Notch; D029961:Zebrafish Proteins; C064045:delta protein; D016695:Glycosyltransferases; C498390:lfng protein, zebrafish