[Guinea pig model of basilar artery thrombosis induced by ferric chloride].
OBJECTIVE
The present work was undertaken to establish an animal model of basilar arterial thrombosis.


METHODS
The bilateral carotid arterial of guinea pigs were ligated and 40% ferric chloride solution was applied to basilar artery topically. The blood flow of cochlea(CBF) was measured continuously with laser doppler flow-meter. The mean arterial pressure (MABP) was recorded simultaneously. The data was analysed by t-test.


RESULTS
After the administration of 40% FeCl3 to basilar artery, The CBF began decrease significantly from 5 to 10 min, and declined more great along with the prolongation of FeCl3 effect. The CBF reached to (64.5 +/- 4.2)% of the base level at 50 min after FeCl3 exposure. A total average decrease of CBF was (81.3 +/- 12.0)% of the base level throughout the experiment period. The MABP had no significant change.


CONCLUSIONS
The topical application of 40% FeCl3 solution can offer an ideal model of basilar artery thrombosis.
D000818:Animals; D001488:Basilar Artery; D002712:Chlorides; D003051:Cochlea / Q000098:blood supply; D004195:Disease Models, Animal; D005290:Ferric Compounds; D006168:Guinea Pigs; D020767:Intracranial Thrombosis / Q000139:chemically induced; D008297:Male; D008833:Microcirculation
D002712:Chlorides; D005290:Ferric Compounds; C024555:ferric chloride