Early-phase neutrophilia in cigarette smoke-induced acute eosinophilic pneumonia.
Although cigarette smoking is a recognized cause of acute eosinophilic pneumonia (AEP), and an increase in eosinophils in the lung is a common occurrence in AEP, early-phase neutrophilia in AEP is not well understood. We describe three cases of cigarette smoke (menthol type)-induced AEP with neutrophilia in the lungs or blood. Increased in-vitro production of the neutrophil chemoattractant interleukin (IL)-8 by human bronchial epithelial cells (HBECs) was correlated with neutrophilia. We suggest that IL-8 released from HBECs is involved in neutrophilia in the lung in AEP, and is newly recognized as an important factor in the early phase of AEP development.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001706:Biopsy / Q000379:methods; D001980:Bronchi / Q000166:cytology; D018929:Cell Culture Techniques; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000276:immunology; D007964:Leukocytosis / Q000209:etiology* / Q000276:immunology; D008168:Lung / Q000276:immunology / Q000473:pathology*; D008297:Male; D009504:Neutrophils; D011657:Pulmonary Eosinophilia / Q000209:etiology* / Q000276:immunology; D020545:Respiratory Mucosa / Q000276:immunology; D012906:Smoke; D012907:Smoking / Q000009:adverse effects*; D014026:Nicotiana
D016209:Interleukin-8; D012906:Smoke