The use of virologically compromised organs in liver transplantation.
The present organ donor crisis has led to accepted use of organs from donors infected with hepatitis C virus (HCV) and hepatitis B virus (HBV). Although capable of transmitting disease, these grafts offer opportunities to expand the donor pool for certain populations. Anti-HBc positive grafts can be used if care is taken to provide prophylaxis. Good quality grafts from HCV+ donors may be used in recipients who are themselves HCV+ with good outcomes.
D006085:Graft Survival / Q000276:immunology; D016174:Hepacivirus / Q000254:growth & development*; D006515:Hepatitis B virus / Q000254:growth & development*; D019694:Hepatitis B, Chronic / Q000635:transmission / Q000821:virology*; D019698:Hepatitis C, Chronic / Q000635:transmission / Q000821:virology*; D006801:Humans; D016031:Liver Transplantation; D012008:Recurrence; D016019:Survival Analysis