[Late-onset Wilsońs disease].
A 58-year old male with a past history of psychiatric disorders was studied for a persistent serum transaminase increase. Low serum ceruloplasmin level (lower than 3 mg/dL), increased urinary copper excretion, and increased liver tissue copper concentration (1050 mcg/g dry weight) confirmed the diagnosis of Wilsońs disease. Slit lamp examination did not show Kayser-Fleischer rings. D-penicilamin therapy was followed by serum transaminase normalization. Similar late-onset cases of Wilsońs disease are exceptional, but confirm the clinical heterogeneity of the disease.
D002614:Chelating Agents / Q000627:therapeutic use*; D003300:Copper / Q000097:blood / Q000652:urine; D006527:Hepatolenticular Degeneration / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
D002614:Chelating Agents; D003300:Copper; D010396:Penicillamine