title: Cell biology. An age of instability.
abstract: It is well established that as we age our cancer risk increases dramatically. As Sinclair explains in his Perspective, the link between cancer and aging is now solidified by new work in budding yeast (McMurray and Gottschling). As yeast cells age there is a marked increase in their genetic instability (a hallmark of cancer), which is independent of the mechanism that determines their life-span.
mesh_terms: D000375:Aging; D000818:Animals; D002455:Cell Division; D016922:Cellular Senescence; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D004271:DNA, Fungal / Q000378:metabolism / Q000502:physiology; D004275:DNA, Ribosomal / Q000378:metabolism; D005800:Genes, Fungal; D020459:Genes, rRNA; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000502:physiology*
chemical_list: D004271:DNA, Fungal; D004275:DNA, Ribosomal