title: Acquired factor VIII inhibitor in a non-haemophilic boy.
abstract: We describe the case of a previously healthy 8-year-old non-haemophilic boy who developed a factor VIII inhibitor of unknown origin. The symptoms of this disease were haemorrhages in the muscles of the right thigh, numerous bruises and a large haematoma of the right crus with subsequent tissue necrosis. Activated and non-activated prothrombin complex concentrates were administered in the therapy of the haemorrhages. To eliminate factor VIII inhibitor, the patient was treated first with prednisone, then immunoglobulin G and finally with a combination of prednisone and cycylophosphamide, without any effect. A total spontaneous remission was observed after 15 months from the beginning of the disease.
mesh_terms: D019774:Blood Coagulation Factor Inhibitors / Q000097:blood*; D002648:Child; D005169:Factor VIII / Q000037:antagonists & inhibitors*; D006467:Hemophilia A / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D009135:Muscular Diseases / Q000209:etiology
chemical_list: D019774:Blood Coagulation Factor Inhibitors; D007166:Immunosuppressive Agents; D005169:Factor VIII