Role of myristoylation in the intracellular targeting of neuronal calcium sensor (NCS) proteins.
The control of the intracellular localization of NCS (neuronal calcium sensor) proteins is of importance for their ability to respond appropriately to differing calcium signals. We examine the localization of three NCS proteins: NCS-1, KChIP-1 (potassium-channel-interacting protein 1) and hippocalcin. Additionally, the [Ca(2+)] dependency of the calcium-induced translocation of hippocalcin is investigated. The implications of the differential targeting of these proteins on calcium signal interpretation are considered.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D051597:Hippocalcin; D006801:Humans; D008954:Models, Biological; D009227:Myristic Acids / Q000378:metabolism*; D009419:Nerve Tissue Proteins; D051580:Neuronal Calcium-Sensor Proteins; D009474:Neurons / Q000378:metabolism*; D009479:Neuropeptides / Q000378:metabolism*; D011485:Protein Binding; D021381:Protein Transport; D015398:Signal Transduction; D013997:Time Factors
D002135:Calcium-Binding Proteins; C496691:HPCA protein, human; D009227:Myristic Acids; D009419:Nerve Tissue Proteins; D051580:Neuronal Calcium-Sensor Proteins; D009479:Neuropeptides; C101464:frequenin calcium sensor proteins; D051597:Hippocalcin; D002118:Calcium