Synthesis of oligosaccharides on soluble high-molecular-weight branched polymers in combination with purification by nanofiltration.
[structure: see text] An efficient approach for polymer-supported oligosaccharide synthesis is described whereby branched and high-molecular-weight PEG derivatives are used in combination with purification by nanofiltration. This methodology was applied to the preparation of a tetraglucoside and the tumor-associated antigen Le(x).
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000737:chemistry / Q000302:isolation & purification; D005374:Filtration / Q000379:methods; D007983:Lewis Blood Group Antigens / Q000737:chemistry; D008970:Molecular Weight; D036103:Nanotechnology / Q000379:methods; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility
D015295:Antigens, Tumor-Associated, Carbohydrate; D007983:Lewis Blood Group Antigens; D009844:Oligosaccharides; D011092:Polyethylene Glycols