A preliminary pathological study on human allotransplantation.
OBJECTIVE
To observe the survival of hand allograft under the state of immunosuppression and the pathological changes of rejection in the recovery process.


METHODS
The biopsies of the skin, nerve, muscle, tendon and bone tissue of hand allografts during different stages from 1 day to 7 months after operation were observed using routine histological technique.


RESULTS
No significant changes due to rejection in skin, nerve, muscle and bone tissue were observed. But different degrees of weak rejective changes were found on the wall of blood vessels; in the muscle and nerve the reactions were markedly stronger than those found in skin tissues.


CONCLUSIONS
The rejection in deep tissues should be monitored in controlling the rejection of hand allograft.
D000328:Adult; D001706:Biopsy; D006084:Graft Rejection / Q000473:pathology*; D063987:Hand Transplantation; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D012867:Skin / Q000276:immunology / Q000473:pathology*; D014184:Transplantation, Homologous