[Prognostic value of molecular biologogy and immunologic parameters in human pancreatic carcinoma].
In the present study we investigated the prognostic relevance of molecular and immunological changes in pancreatic carcinoma. 82 tissue specimens of adenocarcinoma of the pancreas were stained immunohistochemically with following factors: p53, p21WAF1, Cyklin D, EGF, EGF-R, cERB-B2, CD95, BCL-2 and Cathepsin D. We further determined the serum levels of sCD44, sCD44v6, neopterin and IL-2R. Except Cyclin D none of the immunohistochemically determined factors had prognostic significance. Interestingly all of the immunological serum parameters were of high prognostic significance. These data demonstrate the prognostic relevance of immunological parameters in human adenocarcinoma of the pancreas and could raise the possibility of an early immunological intervention in pancreatic cancer.
D000230:Adenocarcinoma / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D001323:Autoantibodies / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D056741:Cyclin D; D016213:Cyclins / Q000097:blood / Q000235:genetics*; D004797:Enzyme-Linked Immunosorbent Assay; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D018960:Hyaluronan Receptors / Q000097:blood; D019798:Neopterin / Q000097:blood; D010179:Pancreas / Q000473:pathology; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D011379:Prognosis; D015375:Receptors, Interleukin-2 / Q000097:blood; D012016:Reference Values; D016159:Tumor Suppressor Protein p53 / Q000276:immunology
D001323:Autoantibodies; D014408:Biomarkers, Tumor; C112697:CD44v6 antigen; D056741:Cyclin D; D016213:Cyclins; D006023:Glycoproteins; D018960:Hyaluronan Receptors; D015375:Receptors, Interleukin-2; D016159:Tumor Suppressor Protein p53; D019798:Neopterin