[Effect of coenzyme Q10 on free radical centers in isolated rat myocardium tissue].
The effect of coenzyme Q10 prepared as an oil solution and a water-soluble suspension (the Kudesan preparation) on the resistance of myocardium of Wistar rats to ischemic and reperfusional injuries and the redox state of the components of the cardiac mitochondrial respiratory chain during postischemic reperfusion was studied. Animals received the oil solution of Q10 with food and the Kudesan preparation, with water. It was shown that the drugs, which produce a substantial protective action on the working heart muscle during ischemia and reperfusion, cause a shift of the redox equilibrium between the semireduced forms of ubiquinone and flavine coenzymes to a higher output of ubisemiquinone. With equal doses of the drugs, Kudesan produced a more pronounced effect.
D000818:Animals; D003067:Coenzymes; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology*
D003067:Coenzymes; D005609:Free Radicals; D014451:Ubiquinone; C024989:coenzyme Q10