Histones accelerate the cyclic 1,N2-propanoguanine adduct-formation of DNA by the primary metabolite of alcohol and carcinogenic crotonaldehyde.
Chemical modification of 2'-deoxyguanosine and DNA by excessive acetaldehyde and crotonaldehyde were significantly accelerated by the presence of histones, which are nuclear proteins very rich in the basic amino acids such as L-arginine and L-lysine, resulting in the smooth and selective formation of the corresponding cyclic 1,N(2)-propanoguanine adducts under physiological conditions. Thus, histones have a very close connection with the genotoxic and carcinogenic effects of these aldehydes.
D000438:Alcohols / Q000633:toxicity*; D000447:Aldehydes / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D004247:DNA / Q000187:drug effects*; D018736:DNA Adducts / Q000096:biosynthesis / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*
D000438:Alcohols; D000447:Aldehydes; D002273:Carcinogens; D018736:DNA Adducts; D006657:Histones; D004247:DNA; C012796:2-butenal