Synthesis of propenamides with anti-malarial activities and 3D-QSAR study.
OBJECTIVE
To establish 3D QSAR model of propenamides with anti-malarial activities.


METHODS
Chemical synthesis combined with comparative molecular field analysis (CoMFA).


RESULTS
Generated QSAR models for activities of inhibiting chloroquine resistive malaria (W2) and chloroquine sensitive malaria (D6).


CONCLUSIONS
The activity of anti-W2 depends mostly on steric interaction and the activity of anti-D6 depends on both steric and electrostatic interaction.
D000178:Acrylamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D008968:Molecular Conformation; D015394:Molecular Structure; D010961:Plasmodium / Q000187:drug effects*; D021281:Quantitative Structure-Activity Relationship
D000178:Acrylamides; D000962:Antimalarials; D002738:Chloroquine