Synthesis and insulin-sensitizing activity of a novel kind of benzopyran derivative.
A series of benzopyran derivatives was synthesized and their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Compounds 6 and 11 exhibited more potent insulin-sensitizing activity than rosiglitazone.
D041721:3T3-L1 Cells; D000818:Animals; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology*; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D001578:Benzopyrans; D003374:Coumarins; D007004:Hypoglycemic Agents; D010080:Oxazoles; C523632:methyl 7-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)coumarin-7-carboxylate