title: Atrophic dermatofibrosarcoma protuberans: case report, review, and proposed molecular mechanisms.
abstract: We report a case of atrophic dermatofibrosarcoma protuberans, an uncommon clinical variant. We discuss molecular and genetic mechanisms of dermatofibrosarcoma protuberans tumorigenesis, review the literature on atrophic dermatofibrosarcoma protuberans, and pose a molecular mechanism for the atrophic variant's phenotype. We also describe using Mohs micrographic excision with CD34 immunostains on the frozen sections to definitively treat the tumor.
mesh_terms: D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D001284:Atrophy; D018223:Dermatofibrosarcoma / Q000235:genetics* / Q000378:metabolism / Q000601:surgery; D005629:Frozen Sections; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D015580:Mohs Surgery; D012878:Skin Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000601:surgery
chemical_list: D018952:Antigens, CD34