A selective biomimetic tweezer for noradrenaline.
The new highly preorganized tweezer molecule 1 binds noradrenaline in polar solvents with unprecedented specificity. It uses a biomimetic recognition pattern and rejects almost all other neurotransmitters. LB experiments on a film balance reflect the same selectivity if 1 is incorporated into a stearic acid monolayer.
D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D007700:Kinetics; D009638:Norepinephrine / Q000737:chemistry*; D063065:Organophosphonates / Q000737:chemistry; D010619:Phenazines / Q000138:chemical synthesis / Q000737:chemistry; D011943:Receptors, Adrenergic, beta / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D000480:Alkynes; D001713:Biphenyl Compounds; D063065:Organophosphonates; D010619:Phenazines; D011943:Receptors, Adrenergic, beta; D009638:Norepinephrine