The secret life of histones.
Recent evidence reveals an unexpected role for the linker histone H1.2 in DNA damage-induced apoptosis. DNA double strand breaks induce translocation of nuclear H1.2 to the cytoplasm, where it promotes release of cytochrome c from mitochondria by activating the Bcl-2 family protein, Bak.
D021581:Active Transport, Cell Nucleus / Q000235:genetics; D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D002467:Cell Nucleus / Q000235:genetics*; D003574:Cytochrome c Group / Q000378:metabolism; D004249:DNA Damage / Q000235:genetics*; D005057:Eukaryotic Cells / Q000378:metabolism*; D006657:Histones / Q000235:genetics*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D050998:bcl-2 Homologous Antagonist-Killer Protein
C494772:BAK1 protein, human; D003574:Cytochrome c Group; D006657:Histones; D008565:Membrane Proteins; D050998:bcl-2 Homologous Antagonist-Killer Protein