Pancreatic endocrine and exocrine function and salivary gland function in autoimmune pancreatitis before and after steroid therapy.
BACKGROUND
Autoimmune pancreatitis (AIP) is a distinct clinical entity in which an autoimmune mechanism may be involved in pathogenesis.


OBJECTIVE
To investigate salivary gland function in addition to pancreatic endocrine and exocrine function in patients with AIP, and to determine changes occurring after steroid therapy.


METHODS
Fasting serum glucose levels, oral glucose tolerance tests or glycosylated hemoglobin values were examined in 19 patients with AIP. N-benzoyl-L-tyrosyl-p-aminobenzoic acid excretion test, sialochemistry and parotid gland scintigraphy were performed in 8 patients.


RESULTS
Eight patients had evidence of DM. Steroid therapy subsequently improved insulin secretion and glycemic control in 3 of 5 patients treated. Pancreatic exocrine function was reduced in 88% of patients. Impaired pancreatic exocrine function improved after steroid therapy in 3 of 6 patients treated. The 3 patients also showed treatment-related improvement in endocrine function. Concentration of beta2-microglobulin in saliva was significantly raised in patients with AIP compared with controls (P < 0.05). Ratio of cumulative peak count to injected radionuclide and washout ratio in parotid scintigraphy in patients with AIP was significantly lower than those of controls (P < 0.01). Salivary gland dysfunction improved after steroid therapy in all 5 patients treated.


CONCLUSIONS
Pancreatic endocrine and exocrine and salivary gland function were frequently impaired in patients with AIP, and steroid therapy was occasionally effective for these dysfunctions.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*; D001786:Blood Glucose / Q000032:analysis; D048909:Diabetes Complications; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects / Q000503:physiopathology*; D010195:Pancreatitis / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*; D010306:Parotid Gland / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology; D011877:Radionuclide Imaging; D012469:Salivary Glands / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology*; D013256:Steroids / Q000494:pharmacology / Q000627:therapeutic use*; D001613:beta 2-Microglobulin / Q000032:analysis
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D013256:Steroids; D001613:beta 2-Microglobulin