Progenitor endothelial cell involvement in Alzheimer's disease.
There is compelling evidence that endothelial cells of the brain and periphery are dysfunctional in Alzheimer's disease. There is evidence for a fundamental defect in, or abnormal aging of, endothelial progenitor cells in atherosclerosis. The possibility that endothelial cell defects are a primary cause for Alzheimer's disease or other dementias can be researched by molecular and cell biology studies as well as cell trafficking studies using recently demonstrated molecular imaging methods. The evidence for abnormal endothelial function and the methods to explore this hypothesis are presented.
D000544:Alzheimer Disease / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001424:Bacterial Infections / Q000150:complications / Q000276:immunology / Q000503:physiopathology; D002536:Cerebral Arteries / Q000254:growth & development* / Q000473:pathology / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D004660:Encephalitis / Q000139:chemically induced / Q000276:immunology / Q000382:microbiology; D004730:Endothelium, Vascular / Q000254:growth & development* / Q000473:pathology / Q000503:physiopathology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology; D006801:Humans; D012038:Regeneration / Q000502:physiology; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*