title: Thiersindoles A-C: new indole diterpenoids from Penicillium thiersii.
abstract: Three new 3-substituted indole diterpenoids (thiersindoles A-C; 1-3) have been isolated from organic extracts of a new Penicillium species (P. thiersii). Their structures, including absolute stereochemistry, were determined by analysis of NMR data and application of Mosher's method. Thiersindoles A-C are biogenetically related to the aflavinines, although the [6,6,5] tricyclic diterpenoid skeleton in compounds 1 and 2 is unprecedented in any of the known members of this class.
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D007211:Indoles / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D004224:Diterpenes; D007211:Indoles; C481741:thiersindole A; C481744:thiersindole B; C481742:thiersindole C