Incidence of major congenital malformations in a region of Bosnia and Herzegovina allegedly polluted with depleted uranium.
OBJECTIVE
To determine the prevalence of major congenital malformations in West Herzegovina, a part of Bosnia and Herzegovina, immediately and five years after 1991-1995 military activities, which allegedly included the use of weapons with depleted uranium.


METHODS
The study included all live-born and stillborn neonates and excluded all aborted fetuses in two one-year cohorts (1995 and 2000) of neonates in the Maternity Ward of the Mostar University Hospital. Malformations were recorded according to the recommendations of the EUROCAT protocol.


RESULTS
Major malformations were found in 40 (2.16%) out of 1,853 neonates in 1995 (95% confidence interval [CI], 1.49-2.82%) and in 33 (2.26%) out of 1,463 neonates five years later (95% CI, 1.50-3.01%), ie, at comparable prevalence. In both cohorts, anomalies of the musculoskeletal system were the most common, followed by anomalies of the digestive system (in 1995) and the cardiovascular system (in 2000). The prevalence of malformations and the organ systems involved were essentially comparable with those in other populations not affected by military activities.


CONCLUSIONS
Despite alleged environmental pollution in some regions of the former Yugoslavia, which was attributed to military activities and the presence of depleted uranium (the "Balkan syndrome"), there was no significant postwar increase in the prevalence of congenital malformations.
D017522:Bosnia and Herzegovina / Q000453:epidemiology; D015331:Cohort Studies; D000013:Congenital Abnormalities / Q000145:classification / Q000453:epidemiology* / Q000209:etiology; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D005313:Fetal Death; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008137:Longitudinal Studies; D009689:Nuclear Warfare; D011247:Pregnancy; D011256:Pregnancy Outcome; D011848:Radioactive Pollutants / Q000633:toxicity*; D014501:Uranium / Q000633:toxicity*
D011848:Radioactive Pollutants; D014501:Uranium