Effects of nicorine, nornicotine and allylnornicotine on the diuretic response to water in rats.
The LD50 in mice for nicotine, (-)-nornicotine and allylnornicotine given intraperitoneally was respectively 10 mg/kg, 18.8 mg/kg and 93.3 mg/kg. Whilst nicotine inhibited the renal response in rats to water, (-)-nornicotine and allylnornicotine were without effect. Nicotine antidiuresis was not antagonized by (-)-nornicotine or by allylnornicotine.
D000818:Animals; D004231:Diuresis; D004232:Diuretics; D051379:Mice; D009538:Nicotine / Q000031:analogs & derivatives; D051381:Rats; D014867:Water
D004232:Diuretics; D014867:Water; D009538:Nicotine; C005311:nornicotine
DIURESIS/experimental