[Postnatal physiological development of rats after acute prenatal hypoxia].
The aim of study was to investigate the physiological development of the brain and behaviour in rats subjected to prenatal hypoxia on the 13.5th day of embryogenesis. We have found that such rats manifested a delayed physiological development and a change in nervous tissue of the sensorimotor cortex, as well a disturbed formation of motor responses during the first month of postnatal ontogenesis. During maturation these modifications were in part compensated, however we observed a decrease of the rats' ability to learn new forepaw movements. The destruction of the brain tissue and the modification of neurons composition in the sensorimotor cortex correlated with changes of behaviour at different stages of ontogenesis. Thus, changes of the conditions under which an organism develops during embryogenesis, predetermine a disturbance in ontogenesis and the learning ability.
D000208:Acute Disease; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000502:physiology; D003216:Conditioning, Operant / Q000502:physiology*; D004195:Disease Models, Animal; D005260:Female; D005311:Fetal Hypoxia / Q000503:physiopathology*; D008854:Microscopy, Electron; D009043:Motor Activity / Q000502:physiology*; D009044:Motor Cortex / Q000503:physiopathology* / Q000648:ultrastructure; D009474:Neurons / Q000648:ultrastructure; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013003:Somatosensory Cortex / Q000503:physiopathology* / Q000648:ultrastructure