A novel nucleic acid analogue, 3'-amino-2'-deoxy-3',4'-BNA, with an N3'-->P5' phosphoramidate linkage and an S-type conformation.
A novel bridged nucleic acid, 3'-amino-2'-deoxy-3',4'-BNA, having an N3'-->P5' phosphoramidate linkage and an S-type conformation, was successfully synthesized. It showed selective hybridization ability toward ssDNA complements, and high enzymatic stability against snake venom phosphodiesterase.
D000577:Amides / Q000737:chemistry*; D001483:Base Sequence; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000737:chemistry*; D010756:Phosphoric Acids / Q000737:chemistry*
D000577:Amides; D009696:Nucleic Acids; D010756:Phosphoric Acids; C011067:phosphoramidic acid