A map of the mouse Cyp3a locus.
The mouse Cyp3a locus on chromosome 5 was analyzed by the use of bacterial artificial chromosomes. Five out of the six known Cyp3a genes, Cyp3a11, Cyp3a13, Cyp3a16, Cyp3a25, Cyp3a41 and Cyp3a44 were found to be linked to each other, however, Cyp3a13, possibly because of a distant position from the main body of the locus was not. In the intergenic regions additional Cyp3a genomic sequences were identified providing evidence for duplication events within the locus. Moreover, a Cyp3a41 duplicated gene, Cyp3a41A, is expressed at significant levels as the corresponding mRNA can be detected in the EST database. In line, therefore, with the higher number of mouse versus human CYP3As, the mouse locus covers a larger chromosomal region and appears to be considerably more complex.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D001483:Base Sequence; D002874:Chromosome Mapping; D022202:Chromosomes, Artificial, Bacterial; D051544:Cytochrome P-450 CYP3A; D017931:DNA Primers; D019143:Evolution, Molecular; D020440:Gene Duplication; D008565:Membrane Proteins; D051379:Mice; D008969:Molecular Sequence Data; D010089:Oxidoreductases, N-Demethylating / Q000235:genetics*; D017422:Sequence Analysis, DNA
D017931:DNA Primers; D008565:Membrane Proteins; D001189:Aryl Hydrocarbon Hydroxylases; C496508:Cyp3a11 protein, mouse; C496509:Cyp3a13 protein, mouse; D051544:Cytochrome P-450 CYP3A; D010089:Oxidoreductases, N-Demethylating