Routine quality control of recycled target [18O]water by capillary electrophoresis and gas chromatography.
Recycling of [(18)O]water for [(18)F]fluoride production can be accomplished with reliable results. We have developed sensitive, robust, and rapid analyses of impurities in [(18)O]water. Anions were quantitated by capillary electrophoresis and organic residuals were quantitated by gas chromatography using methods with excellent reproducibility and linearity. Kryptofix 222 (K-222) was quantitated by a sensitive LC-MS-MS technique. Isotopic composition was determined by GC-MS with satisfactory accuracy and precision. These methods were employed to evaluate recovered [(18)O]water purified by a novel electrolysis method. 2-[(18)F]FDG yields using purified [(18)O]water with very low levels of impurities are indistinguishable from newly purchased [(18)O]water. High (> 300 ppm) carbonate concentration reduces the fluoride trapping efficiency of QMA. The analyses of anions, organics, and isotopic enrichment were applied routinely for quality control of [(18)O]water to predict a satisfactory outcome of 2-[(18)F]FDG production.
D002849:Chromatography, Gas / Q000379:methods*; D003247:Conservation of Natural Resources / Q000379:methods; D004355:Drug Stability; D019075:Electrophoresis, Capillary / Q000379:methods*; D019788:Fluorodeoxyglucose F18 / Q000138:chemical synthesis* / Q000302:isolation & purification* / Q000592:standards; D010103:Oxygen Isotopes / Q000737:chemistry* / Q000302:isolation & purification* / Q000592:standards; D011786:Quality Control; D019275:Radiopharmaceuticals / Q000737:chemistry / Q000302:isolation & purification / Q000592:standards; D014867:Water / Q000032:analysis / Q000737:chemistry* / Q000592:standards; D018508:Water Purification / Q000379:methods* / Q000592:standards
D010103:Oxygen Isotopes; D019275:Radiopharmaceuticals; D014867:Water; D019788:Fluorodeoxyglucose F18