Animal models of ocular allergy.
OBJECTIVE
This review focuses on reports on animal models of ocular allergy published within the past year. A number of animal models are currently being used to clarify the pathophysiology of ocular allergy and to improve the therapeutic interventions for this disease.


RESULTS
Published literature examined the role of cytokines and other effector molecules which drive the immunopathology of ocular allergies in several animal models. Animal models were also used to compare the safety and efficacy of currently available drugs, and were utilized in initial trials of novel therapeutic agents. Novel therapeutic options being studied include DNA immunizations and recombinant peptides that block enzymes involved in the inflammatory processes.


CONCLUSIONS
Several animal models are currently being used in the study of ocular allergy. These include different strains within the mouse, rat, guinea pig, rabbit and dog species. Continuing investigations are needed to elucidate the complex molecular and cellular processes involved in the pathogenesis of ocular allergies. A better understanding of the interplay of effector cells, cytokines, adhesion molecules and a number of other inflammatory mediators will broaden our knowledge of the pathophysiology of ocular allergy and allow improved therapeutic options for this disease.
D000818:Animals; D004285:Dogs; D005128:Eye Diseases / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology; D006168:Guinea Pigs; D006801:Humans; D006967:Hypersensitivity / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D051379:Mice; D023421:Models, Animal; D011817:Rabbits; D051381:Rats