Comparison of porous and non-porous teflon membranes plus a xenograft in the treatment of vertical osseous defects: a clinical reentry study.
BACKGROUND
The primary aim of this 9-month randomized, controlled, blinded, clinical reentry study was to compare the regenerative effects of a nonporous polytetrafluoroethylene (NP) periodontal membrane to a porous expanded polytetrafluoroethylene (P) periodontal membrane in the treatment of vertical osseous defects.


METHODS
Twenty-four patients, 11 males and 13 females, age 24 to 74 (mean 50.5 +/- 13.1) provided one site with an intraosseous defect > or = 4 mm and were divided equally and randomly into two groups. Following debridement both groups were grafted with a bovine-derived xenograft coated with a synthetic cell-binding peptide; then the test group received an NP membrane and the control group received a P membrane. All defects were reentered after 9 months. Measurements were performed by a masked examiner.


RESULTS
There were no statistically significant differences (P>0.05) between NP and P groups for any open or closed probing measurement at any time. Similar open initial defect depth for the NP group and P groups (4.8 versus 5.0 mm) demonstrated identical 9-month defect fill of 2.8 mm (57%) for both groups. A difference in crestal resorption for the NP compared to the P group (0.4 versus 0.8 mm) accounted for the difference in mean percent defect resolution, which was 67% for NP compared to 72% for the P group. Overall, nine (75%) of the NP group defects and eight (67%) of the P group defects showed more than 50% defect fill.


CONCLUSIONS
Treatment of vertical osseous defects with nonporous or porous polytetrafluoroethylene membranes in combination with a xenograft resulted in statistically significant improvement in open and closed probing measurements, with no significant difference between treatment groups.
D000328:Adult; D000368:Aged; D016301:Alveolar Bone Loss / Q000601:surgery*; D000818:Animals; D001857:Bone Matrix / Q000637:transplantation*; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000494:pharmacology; D016025:Bone Transplantation / Q000379:methods; D002417:Cattle; D017886:Durapatite; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D019647:Oral Surgical Procedures / Q000379:methods*; D010512:Periodontal Index; D011138:Polytetrafluoroethylene; D016062:Porosity
D018786:Bone Substitutes; D008567:Membranes, Artificial; C403137:PepGen P-15; D011138:Polytetrafluoroethylene; D017886:Durapatite