title: Synthesis of propenamides with anti-malarial activities and 3D-QSAR study.
abstract: OBJECTIVE
  To establish 3D QSAR model of propenamides with anti-malarial activities.
  
  
  METHODS
  Chemical synthesis combined with comparative molecular field analysis (CoMFA).
  
  
  RESULTS
  Generated QSAR models for activities of inhibiting chloroquine resistive malaria (W2) and chloroquine sensitive malaria (D6).
  
  
  CONCLUSIONS
  The activity of anti-W2 depends mostly on steric interaction and the activity of anti-D6 depends on both steric and electrostatic interaction.
mesh_terms: D000178:Acrylamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002738:Chloroquine / Q000494:pharmacology; D004351:Drug Resistance; D008968:Molecular Conformation; D015394:Molecular Structure; D010961:Plasmodium / Q000187:drug effects*; D021281:Quantitative Structure-Activity Relationship
chemical_list: D000178:Acrylamides; D000962:Antimalarials; D002738:Chloroquine