RVP-net: online prediction of real valued accessible surface area of proteins from single sequences.
CONCLUSIONS
RVP-net is an online program for the prediction of real valued solvent accessibility. All previous methods of accessible surface area (ASA) predictions classify amino acid residues into exposure states and named them buried or exposed based on different thresholds. Real values in some cases were generated by taking the mid points of these state thresholds. This is the first method, which provides a direct prediction of ASA without making exposure categories and achieves results better than 19% mean absolute error. To facilitate batch processing of several sequences, a standalone version of this tool is also provided.


BACKGROUND
Online predictions are available at http://www.netasa.org/rvp-net/. Standalone version of the program can be obtained from the corresponding author by E-mail request.
D000465:Algorithms; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D001665:Binding Sites; D030562:Databases, Protein; D020407:Internet; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D009862:Online Systems; D011485:Protein Binding; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D020539:Sequence Analysis, Protein / Q000379:methods*; D012984:Software; D012997:Solvents / Q000737:chemistry*; D013499:Surface Properties
D000596:Amino Acids; D046911:Macromolecular Substances; D011506:Proteins; D012997:Solvents