title: [Does surgical approach have an effect on the development of local infection? Animal experiment comparison of conventional open vs. minimally invasive bone plate osteosynthesis (MIPO)].
abstract: With a standardised model we investigated the influence of two different surgical approaches to the rabbit tibia for plate osteosynthesis on resistance to local infection after postoperative inoculation of graduated concentrations of staphylococcus aureus at the implant. The infection rate for the minimally invasive plate osteosynthesis with insertion of the implant in closed, soft tissue tunneling technique was 25% (3/12 animals; ID50 = 6.2 x 10(6) CFU) and for the conventional open approach 38% (5/13 animals; ID50 = 2 x 10(6) CFU). This difference is statistically not significant (with P < 0.05).
mesh_terms: D000818:Animals; D001860:Bone Plates; D015169:Colony Count, Microbial; D005593:Fracture Fixation, Internal / Q000379:methods*; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D010043:Outcome and Process Assessment, Health Care; D011817:Rabbits; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000254:growth & development*; D013530:Surgical Wound Infection / Q000382:microbiology*; D013977:Tibia / Q000382:microbiology / Q000601:surgery