[Changes in individual resistance of cardiovascular and respiratory systems of rats to posthemorrhagic hypoxia after pharmacological impact on brain function].
In experiments on rats it was shown that injection to rats before hemorrhage of analeptic corasol or prior injections during three days of the inhibitory mediator sodium oxybutyrate decrease individual resistance of the respiratory and circulatory systems (arterial blood pressure, cardiac output, organ portal blood flow) to posthemorrhagic hypoxia. Injection to animals before the hemorrhage of GABA-A antagonist picrotoxin significantly raises individual resistance to massive bleeding. Individual resistance to acute hemorrhage correlates with individual sensitivity of cardiovascular and respiratory systems to corasol.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects*; D018682:GABA Agents / Q000494:pharmacology*; D006470:Hemorrhage / Q000150:complications / Q000503:physiopathology*; D002534:Hypoxia, Brain / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012143:Respiratory Physiological Phenomena / Q000187:drug effects*
D018682:GABA Agents