New bioactive diterpene polyesters from Euphorbia decipiens.
A reinvestigation with a modified extraction procedure of Euphorbia decipiens resulted in the isolation and structure elucidation of three new myrsinane-type diterpene esters (1-3). The structures of compounds 1-3 were elucidated by spectroscopic data interpretation. Compound 1 showed inhibitory activity against prolyl endopeptidase (PEP), whereas compound 2 exhibited DNA-damaging activity in a mutant yeast bioassay.
D045247:Chryseobacterium / Q000201:enzymology; D004249:DNA Damage; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028481:Euphorbia / Q000737:chemistry*; D007492:Iran; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D000085822:Prolyl Oligopeptidases; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012697:Serine Endopeptidases / Q000187:drug effects / Q000378:metabolism; D015842:Serine Proteinase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C481735:3,5,15,17-O-tetraacetyl-7-O-benzoylcheiradone; C481736:3,5,15,17-O-tetraacetyl-7-O-nicotinoylcheiradone; C481733:3,5,17-O-triacetyl-7-O-benzoyl-15-hydroxycheiradone; D004224:Diterpenes; D015842:Serine Proteinase Inhibitors; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases