[New aspects of anti-inflammatory potential of AT III: reduction of reperfusion injury after warm liver ischemia].
Hepatic microcirculation after warm hepatic ischemia in rats can be significantly enhanced by Antithrombin III. The number of sinusoidal stickers as a tool for characterizing the leukocyte-endothelial cell interaction was significantly reduced. The peak of serum transaminases as an indicator of hepatocellular damage was significantly decreased after the AT III application. It has to be concluded that AT III application before Pringle maneuver might significantly reduce the reperfusion damage after liver resection.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000990:Antithrombin III / Q000494:pharmacology*; D008099:Liver / Q000098:blood supply*; D008111:Liver Function Tests; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000503:physiopathology; D009926:Organ Preservation; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000503:physiopathology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000990:Antithrombin III