[Significantly increased concentrations of the angiogenic growth factor bFGF in malignant soft tissue tumors].
Soft tissue sarcomas of the extremities contribute to only 0.9% of all neoplasms. Even in experienced hand radical surgical resection is followed by a recurrency rate of 7 to 35%. The reasons for this high percentage are not yet clear. Since a angiogenesis is a key factor in tumor growth we have investigated concentrations of the angiogenic peptides bFGF, TGF-beta 1, TGF-beta 2 and VEGF in systemic and tumor venous blood of 50 soft tissue sarcoma patients undergoing radical surgical tumor-resection. Systemic blood was obtained preoperatively, during surgery, 1 hour, 1 day and 1 week after surgery. 10cc of venous blood was collected from tumor veins during surgery. Levels of cytokines were measured by Sandwich-ELISA. Preoperative and intraoperative levels were significantly elevated compared to values postoperative. Concentrations of bFGF determined in tumor blood were significantly higher than serum levels but lower than controls obtained from large soft tissue wounds. VEGF and TGF were not elevated.
D016228:Endothelial Growth Factors / Q000097:blood; D016222:Fibroblast Growth Factor 2 / Q000097:blood*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood; D008222:Lymphokines / Q000097:blood; D009389:Neovascularization, Pathologic / Q000097:blood* / Q000473:pathology; D012016:Reference Values; D012509:Sarcoma / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D016212:Transforming Growth Factor beta / Q000097:blood; D053773:Transforming Growth Factor beta1; D053781:Transforming Growth Factor beta2; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D036341:Intercellular Signaling Peptides and Proteins; D008222:Lymphokines; C508960:TGFB1 protein, human; C509041:TGFB2 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D053781:Transforming Growth Factor beta2; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D016222:Fibroblast Growth Factor 2