[Factor V Leiden mutation and pregnancy complications].
It has become evident in the past few years, that a large number of obstetric pathologies is actually associated with congenital thrombophilias. The most common disorder is Factor V Leiden. Many authors relate this factor with preeclampsia, intrauterine fetal growth retardation, spontaneous abortion, unexplained cases of still birth, placental abruption, and thromboembolic complications during and after parturition. The article discusses the current publications on this topic. Up till now only venous thromboembolism has been statistically proven to be associated with Factor V Leiden. The relationship between Factor V Leiden and the above obstetric pathologies is to be discussed. For this reason, according to the ACCP Consensus strong recommendations only exist for the prophylaxis and treatment of venous thromboembolism.
D000022:Abortion, Spontaneous / Q000209:etiology; D020016:Activated Protein C Resistance / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D001241:Aspirin / Q000627:therapeutic use; D005165:Factor V / Q000235:genetics*; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005317:Fetal Growth Retardation / Q000209:etiology; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D017354:Point Mutation; D011225:Pre-Eclampsia / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology* / Q000517:prevention & control; D011249:Pregnancy Complications, Cardiovascular / Q000209:etiology / Q000517:prevention & control; D011250:Pregnancy Complications, Hematologic / Q000209:etiology / Q000517:prevention & control; D011644:Puerperal Disorders / Q000209:etiology; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D013923:Thromboembolism / Q000209:etiology / Q000517:prevention & control; D020246:Venous Thrombosis / Q000188:drug therapy / Q000209:etiology
D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; C095381:factor V Leiden; D005165:Factor V; D001241:Aspirin