title: Elimination of ventilator dead space during synchronized ventilation in premature infants.
abstract: BACKGROUND
  Mainstream airflow sensors used in neonatal ventilators to synchronize mechanical breaths with spontaneous inspiration and measure ventilation increase dead space and may impair carbon dioxide (CO(2)) elimination.
  
  
  OBJECTIVE
  To evaluate a technique consisting of a continuous gas leakage at the endotracheal tube (ETT) adapter to wash out the airflow sensor for synchronization and ventilation monitoring without CO(2) rebreathing in preterm infants.
  
  
  METHODS
  Minute ventilation (V'(E)) by respiratory inductance plethysmography, end-inspiratory and end-expiratory CO(2) by side-stream microcapnography, and transcutaneous CO(2) tension (TcPCO(2)) were measured in 10 infants (body weight, 835+/-244 g; gestational age, 26+/-2 weeks; age, 19+/-9 days; weight, 856+/-206 g; ventilator rate, 21+/-6 beats/min; PIP, 16+/-1 centimeters of water (cmH(2)O); PEEP, 4.2+/-0.4 cmH(2)O; fraction of inspired oxygen (FIo(2)), 0.26+/-0.6). The measurements were made during four 30-minute periods in random order: IMV (without airflow sensor), IMV+Sensor, SIMV (with airflow sensor), and SIMV+Leak (ETT adapter continuous leakage).
  
  
  RESULTS
  Airflow sensor presence during SIMV and IMV+Sensor periods resulted in higher end-inspiratory and end-expiratory CO(2), Tcpco(2), and spontaneous V'(E) compared with IMV. These effects were not observed during SIMV+Leak.
  
  
  CONCLUSIONS
  The significant physiologic effects of airflow sensor dead space during synchronized ventilation in preterm infants can be effectively prevented by the ETT adapter continuous leakage technique.
mesh_terms: D001784:Blood Gas Analysis; D019296:Capnography; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007385:Intermittent Positive-Pressure Ventilation / Q000009:adverse effects / Q000379:methods*; D007442:Intubation, Intratracheal / Q000009:adverse effects / Q000379:methods*; D008171:Lung Diseases / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control*; D010993:Plethysmography, Whole Body; D012120:Respiration Disorders / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D012126:Respiratory Dead Space / Q000502:physiology*; D012720:Severity of Illness Index; D012122:Ventilators, Mechanical / Q000009:adverse effects*