[Oxaceprol reduced leukocyte adhesion and extravasation and preserves perfusion of tissue after ischemia/reperfusion].
The present data indicate that treatment with Oxaceprol results in a significant protection of the microvasculature against I/R injury. The infusion of Oxaceprol during reperfusion leads to a significant reduction in the post-ischemic leukocyte adherence and extravasation as well as an improvement of the nutritive perfusion of the skin muscle. Thus, Oxaceprol treatment would appear to be a promising therapy for the reduction of I/R injury.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects* / Q000276:immunology; D002448:Cell Adhesion / Q000187:drug effects* / Q000276:immunology; D006224:Cricetinae; D006909:Hydroxyproline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects* / Q000276:immunology; D008647:Mesocricetus; D008833:Microcirculation / Q000187:drug effects / Q000276:immunology; D008856:Microscopy, Fluorescence; D018482:Muscle, Skeletal / Q000098:blood supply*; D015427:Reperfusion Injury / Q000276:immunology*; D012884:Skin Window Technique
D000894:Anti-Inflammatory Agents, Non-Steroidal; C012393:oxaceprol; D006909:Hydroxyproline