Synthesis and biological evaluation of thymine nucleosides fused with 3',4'-tetrahydrofuran ring.
The pyrimidine nucleosides fused with 3',4'-tetrahydrofuran ring were successfully synthesized, starting from 1,2;5,6-di-O-isopropylidene-D-glucose and assayed for antiviral activities against HIV-1, HIV-2, EMCV, Cox. B3 and VSV. Thymine analogue (5) and its corresponding 2'-deoxy analogue (6) exhibited high cytotoxicity instead of giving antiviral activities.
D002460:Cell Line; D005663:Furans / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D013941:Thymine / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014780:Viruses / Q000187:drug effects
D005663:Furans; C018674:tetrahydrofuran; D013941:Thymine