Prostanoid-induced modulation of neuropeptide Y and noradrenaline release from the rat mesenteric bed.
1. A variety of prostanoids were examined for their ability to alter the periarterial nerve stimulation-induced release of noradrenaline (NA) and neuropeptide Y immunoreactive compounds (NPY-ir) from the perfused mesenteric arterial bed of the rat. 2. Periarterial nerve stimulation (16 Hz) increased the overflow of NA, NPY-ir and perfusion pressure. 3. The prostacyclin (PGI2) analogues, carbaPGI2 and cicaprost both produced a concentration-dependent attenuation of the nerve stimulation-induced increase in NA, NPY-ir overflow and perfusion pressure. 4. The prostaglandin (PG) analogue PGE2 attenuated the evoked increase in NPY-ir overflow as well as a modest decrease in NA. 5. PGE1, sulprostone and iloprost attenuated the nerve stimulation-induced increase in NA overflow but not NPY-ir. 6. Neither PGF2alpha nor the thromboxane A2 analogue U46619 altered the evoked increase in NA or NPY-ir overflow. 7. The results support the view that sympathetic co-transmitter release can be differentially modulated by paracrine/autocrine mediators at sympathetic neuroeffector junctions.
D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / Q000008:administration & dosage; D000527:Alprostadil / Q000494:pharmacology; D000818:Animals; D015237:Dinoprost / Q000008:administration & dosage / Q000031:analogs & derivatives; D015232:Dinoprostone / Q000031:analogs & derivatives* / Q000494:pharmacology; D004558:Electric Stimulation / Q000379:methods; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000494:pharmacology; D016285:Iloprost / Q000494:pharmacology; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects / Q000294:innervation / Q000378:metabolism*; D009478:Neuropeptide Y / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D009638:Norepinephrine / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D010477:Perfusion / Q000379:methods; D011453:Prostaglandins / Q000494:pharmacology*; D011863:Radioimmunoassay / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley
D009478:Neuropeptide Y; D011453:Prostaglandins; C075750:8-epi-prostaglandin F2alpha; C016767:sulprostone; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D015237:Dinoprost; D011464:Epoprostenol; D000527:Alprostadil; D016285:Iloprost; D015232:Dinoprostone; C043867:cicaprost; D009638:Norepinephrine