Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells.
The classical paradigm for dendritic cell function derives from the study of Langerhans cells, which predominate within skin epidermis. After an encounter with foreign agents, Langerhans cells are thought to migrate to draining lymph nodes, where they initiate T cell priming. Contrary to this, we show here that infection of murine epidermis by herpes simplex virus did not result in the priming of virus-specific cytotoxic T lymphocytes by Langerhans cells. Rather, the priming response required a distinct CD8alpha+ dendritic cell subset. Thus, the traditional view of Langerhans cells in epidermal immunity needs to be revisited to accommodate a requirement for other dendritic cells in this response.
D000818:Animals; D017951:Antigen Presentation; D015703:Antigens, CD / Q000032:analysis; D000956:Antigens, Viral / Q000276:immunology; D016827:CD8 Antigens / Q000032:analysis*; D002469:Cell Separation; D002678:Chimera; D003602:Cytotoxicity, Immunologic; D003713:Dendritic Cells / Q000276:immunology*; D004817:Epidermis / Q000276:immunology*; D006183:H-2 Antigens / Q000032:analysis / Q000276:immunology; D006561:Herpes Simplex / Q000276:immunology*; D018259:Herpesvirus 1, Human / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D007801:Langerhans Cells / Q000276:immunology*; D037181:Lectins, C-Type / Q000032:analysis; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D008822:Mice, Transgenic; D015778:Minor Histocompatibility Antigens; D011956:Receptors, Cell Surface / Q000032:analysis; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000276:immunology
D015703:Antigens, CD; D000956:Antigens, Viral; D016827:CD8 Antigens; C431698:CD8alpha antigen; C093569:DEC-205 receptor; D006183:H-2 Antigens; C032876:H-2Kb protein, mouse; D000949:Histocompatibility Antigens Class II; D037181:Lectins, C-Type; D015778:Minor Histocompatibility Antigens; D011956:Receptors, Cell Surface; D014759:Viral Envelope Proteins; C040495:glycoprotein B, Simplexvirus