[Endotoxin inhibits apoptosis of neutrophilic granulocytes via tyrosine phosphorylation].
The activation of tyrosine phosphorylation plays a pivotal role for endotoxin induced inhibition of PMN-apoptosis. Modulation of tyrosine phosphorylation with specific inhibitors attenuates endotoxin induced prolongation of PMN-lifespan.
D017209:Apoptosis / Q000276:immunology*; D019446:Endotoxemia / Q000276:immunology*; D004789:Enzyme Activation / Q000502:physiology; D004926:Escherichia coli / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D012772:Shock, Septic / Q000276:immunology*
D008070:Lipopolysaccharides; D011505:Protein-Tyrosine Kinases