[Microbial transformation of sinenxan A, a rich constituent in callus cultures of Taxus].
OBJECTIVE
To study the microbial transformation of sinenxan A.


METHODS
Choose two strains of Fungi (Mucor spinosus AS 3.3450 and Cunninghamella echinulata AS 3.3400) and a strain of bacterium (Proteus vulgaris AS 1.1208) to transform the substrate.


RESULTS
Three products were obtained and identified as 10-deacetylsinenxan A1, 6 alpha-hydroxy-10-deacetylsinenxan A2 and 9 alpha-hydroxy-10-deacetylsinenxan A3 respectively.


CONCLUSIONS
Sinenxan A is facile to be transformed by microorganisms, the 10-acetyl group of which is an active group.
D000085:Acetates / Q000302:isolation & purification / Q000378:metabolism; D001711:Biotransformation; D046508:Culture Techniques; D020093:Cunninghamella / Q000378:metabolism; D004224:Diterpenes / Q000302:isolation & purification / Q000378:metabolism; D009089:Mucor / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry; D011514:Proteus vulgaris / Q000378:metabolism; D020946:Taxus / Q000737:chemistry*
D000085:Acetates; D004224:Diterpenes; C484850:sinenxan A