[Mini-transplantation from cord blood].
Feasibility of reduced-intensity stem cell transplantation(RIST) has been demonstrated from an HLA-identical sibling, but using unrelated umbilical cord blood(RICBT) has not been fully investigated. To evaluate the engraftment of RICBT, we investigated 11 patients who underwent CBT following fludarabine, melphalan and low-dose TBI regimens and used cyclosporine. Both 100% donor chimerism and neutrophil engraftment were achieved a median of 27 days and 19 days. Three of evaluable eight patients developed grade II-IV acute GVHD and one of the four developed chronic GVHD. Five died of RRT within 100 days. The estimated 1-year OS was 34%. Donor chimerism and neutrophil engraftment were achieved smoothly and rapidly, but RRT was high. However, further verification of feasibility of RICBT is necessary.
D002066:Busulfan; D003520:Cyclophosphamide; D005312:Fetal Blood / Q000637:transplantation*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D008558:Melphalan; D018183:Transplantation Chimera; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D014740:Vidarabine / Q000031:analogs & derivatives*; D014916:Whole-Body Irradiation
D003520:Cyclophosphamide; D014740:Vidarabine; D002066:Busulfan; C024352:fludarabine; D008558:Melphalan