Immunomodulatory activity of the dimerized lysozyme KLP-602 after earlier suppression by atrazine in carp (Cyprinus carpio L.).
The purpose of this study was to determine the possibility of modulation of the cellular immune response with the dimer of lysozyme KLP-602 in fish after suppression induced by atrazine. In the in vivo studies fish were intoxicated with atrazine at a dose of 1/4 LD50, then after 48 hours the dimer of lysozyme KLP-602 was administerd at a dose of 0.02 mg/kg of body weight. After 2, 3, 5, 7 and 10 days after intoxication cells from the blood and pronephros of carp were isolated. In the study we determined the metabolic activity of phagocyte cells and the proliferative ability of T and B lymphocytes. This study showed that administration of the dimer of lysozyme KLP-602 stimulated and corrected the handicapped immunity.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001280:Atrazine; D002347:Carps / Q000276:immunology*; D007107:Immune System / Q000187:drug effects*; D007111:Immunity, Cellular; D009113:Muramidase / Q000008:administration & dosage / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects
D000276:Adjuvants, Immunologic; D009113:Muramidase; D001280:Atrazine