The effect of acridine moiety for binding and reaction of Cu(II)[1 ,4,7-triazacyclononane] with DNA.
The orientation and the dynamic behavior of Cu(II) complex of 1,4,7-triazacyclononane ([9]aneN3) and its acridine conjugate on B-form DNA fiber have been investigated by EPR spectroscopy. It has been shown that a Cu([9]aneN3)2+ binds to DNA with two different binding modes at room temperature; one species is rapidly moving and the other is immobilized randomly on the DNA. An introduction of acridine to 1,4,7-triazacyclononane fixed the orientation of all the Cu(II) complex with the g// axis perpendicular to DNA fiber axis, indicating that the tetragonal coordination plane is almost parallel to the DNA double helical axis.
D000166:Acridines / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D009942:Organometallic Compounds / Q000737:chemistry*
D000166:Acridines; D009942:Organometallic Compounds; C478251:diaqua(1,4,7-triazacyclononane)copper(II); D004247:DNA