A third mode of integrin antagonism.
Through the biochemical dissection of conformational changes, Shimaoka et al. (this issue of Immunity) have delineated a novel role for the I-like domain in the allosteric regulation of LFA-1 function and signaling. This work advances our understanding of LFA-1 antagonism and reveals new avenues for approaching LFA-1, and potentially other I-domain containing integrins, as drug targets.
D000495:Allosteric Site / Q000502:physiology; D000818:Animals; D016023:Integrins / Q000037:antagonists & inhibitors*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000378:metabolism*; D051379:Mice; D015398:Signal Transduction / Q000502:physiology*
D016023:Integrins; D016169:Lymphocyte Function-Associated Antigen-1