title: Classical chemotherapy: mechanisms, toxicities and the therapeutic window.
abstract: Chemotherapy can be best used by understanding the principles of pharmacology, tumor biology, cellular kinetics and drug resistance. Here we try to focus on the major classes of chemotherapeutic drugs, their mechanisms of action, toxicities; and the therapeutic window.
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007700:Kinetics; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents