title: Stationary phase mutagenesis: mechanisms that accelerate adaptation of microbial populations under environmental stress.
abstract: Microorganisms are exposed to constantly changing environmental conditions. In a growth-restricting environment (e.g. during starvation), mutants arise that are able to take over the population by a process known as stationary phase mutation. Genetic adaptation of a microbial population under environmental stress involves mechanisms that lead to an elevated mutation rate. Under stressful conditions, DNA synthesis may become more erroneous because of the induction of error-prone DNA polymerases, resulting in a situation in which DNA repair systems are unable to cope with increasing amounts of DNA lesions. Transposition may also increase genetic variation. One may ask whether the rate of mutation under stressful conditions is elevated as a result of malfunctioning of systems responsible for accuracy or are there specific mechanisms that regulate the rate of mutations under stress. Evidence for the presence of mutagenic pathways that have probably been evolved to control the mutation rate in a cell will be discussed.
mesh_terms: D000220:Adaptation, Biological; D001419:Bacteria / Q000235:genetics*; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000378:metabolism; D005075:Biological Evolution; D004260:DNA Repair; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D004777:Environment; D016296:Mutagenesis
chemical_list: D001426:Bacterial Proteins; D004259:DNA-Directed DNA Polymerase