Impact of genetic analysis on Parkinson's disease research.
Genetic analysis is changing our view of Parkinson's disease: not only is it challenging the long-cherished views about the diagnosis of the disease, it is also starting to suggest a biochemical pathway to disease pathogenesis. These developments are reviewed in the context of three known (synuclein, parkin, and DJ-1) and one suspected (ubiquitin hydrolase) genes for the disease.
D003546:Cysteine Endopeptidases / Q000235:genetics*; D004252:DNA Mutational Analysis; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D009097:Multienzyme Complexes / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D015513:Oncogene Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000175:diagnosis / Q000235:genetics*; D046988:Proteasome Endopeptidase Complex; D000071617:Protein Deglycase DJ-1; D051843:Synucleins; D025801:Ubiquitin / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
D047908:Intracellular Signaling Peptides and Proteins; D009097:Multienzyme Complexes; D009419:Nerve Tissue Proteins; D015513:Oncogene Proteins; D051843:Synucleins; D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex