Optimization of an ATP-binding ribonucleopeptide receptor.
We describe here a new strategy for the selection and evolution of functional RNA-peptide complexes. An ATP-binding ribonucleopeptide was obtained by means of a structure-based design of ribonucleopeptide domain and by in vitro selection of the RNA subunit of the ribonucleopeptide. Approaches to optimize the ligand-binding selectivity of ribonucleopeptide will be discussed.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D001483:Base Sequence; D009841:Oligonucleotides; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000378:metabolism*
D009841:Oligonucleotides; D011956:Receptors, Cell Surface; D012261:Ribonucleoproteins; D000255:Adenosine Triphosphate