Highly enantioselective catalytic phenylation of ketones with a constrained geometry titanium catalyst.
[reaction: see text] The catalytic asymmetric addition of phenyl groups from diphenylzinc to ketones is reported. The catalyst, generated from a dihydroxy bis(sulfonamide) ligand and titanium tetraisopropoxide, gives good to excellent enantioselectivities with a range of substrates.
D001713:Biphenyl Compounds / Q000737:chemistry; D002384:Catalysis; D007202:Indicators and Reagents; D007659:Ketones / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature; D014025:Titanium / Q000737:chemistry*
D001713:Biphenyl Compounds; D007202:Indicators and Reagents; D007659:Ketones; D012997:Solvents; D014025:Titanium