title: Severe encephalopathy caused by intraparenchymal methotrexate instillation due to the design of the catheter.
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy; D002404:Catheterization / Q000009:adverse effects; D002675:Child, Preschool; D004868:Equipment Failure; D006801:Humans; D007276:Injections, Intraventricular / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008297:Male; D008527:Medulloblastoma / Q000175:diagnosis / Q000188:drug therapy; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use; D020258:Neurotoxicity Syndromes / Q000175:diagnosis / Q000209:etiology*; D011322:Primary Prevention / Q000379:methods; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D008727:Methotrexate