Beta-adrenergic receptor polymorphisms in patients with elevated factor VIII levels with venous thrombosis.
Beta-blockers significantly reduce elevated factor VIII (FVIII) levels in patients with venous thromboembolism (VTE). To determine whether beta-adrenergic receptors are important in the aetiology of high FVIII levels, we investigated four coding polymorphisms of the beta1- and beta2-receptor genes in 64 patients with high FVIII and VTE and 100 healthy controls. Genotypic and allelic frequencies were not significantly different between the patient and control groups. However, a significant dosage effect of the beta2 E27 allele on plasma FVIII coagulant activity levels was observed in normal group O individuals.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D001777:Blood Coagulation / Q000235:genetics; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005169:Factor VIII / Q000032:analysis*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011655:Pulmonary Embolism / Q000097:blood / Q000235:genetics; D011943:Receptors, Adrenergic, beta / Q000235:genetics*; D020246:Venous Thrombosis / Q000097:blood / Q000235:genetics*
D011943:Receptors, Adrenergic, beta; D005169:Factor VIII