[Effect of physical training on M-cholinergic-blocking activity of blood serum in acute coronary disease].
On 93 longitudinal strips of 31 rats' uterus horns, M-cholinoblocking agent activity in 50-, 100-, 500-, 1000- and 10,000-fold dilution of the blood serum taken from 10 healthy older subjects and 40 patients after an acute coronary incident, was studied, 10 patients being engaged in physical training. Findings suggest presence of an endogenous M-cholinoreceptor blocking agent in the blood with lisophosphatidylcholin as the basic component. An acute coronary incident seems to reduce the efficiency of the M-cholinergic effect on the heart and vessels.
D000109:Acetylcholine / Q000494:pharmacology; D000208:Acute Disease; D000818:Animals; D003327:Coronary Disease / Q000097:blood* / Q000378:metabolism / Q000534:rehabilitation*; D005081:Exercise Therapy; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000097:blood* / Q000494:pharmacology; D051381:Rats; D011976:Receptors, Muscarinic / Q000502:physiology*; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects
D018727:Muscarinic Antagonists; D011976:Receptors, Muscarinic; D000109:Acetylcholine