[Significance of alpha 2,6-specific sialyltransferase ST6N and alpha 2,3-specific sialyltransferase ST3N in stomach carcinoma].
The objective of this prospective study was to investigate the role of sialytransferase activities in patients with gastric cancer. In patients with gastric cancer we observed a significant correlation between sialyltransferase ST6N levels and survival after a median follow up of one year. High ST6N levels in the tumor and the surrounding normal mucosa were associated with poor prognosis. The results of this pilot study encourage further evaluation of sialyltransferase in patients with gastric cancer.
D001706:Biopsy; D005743:Gastrectomy; D005753:Gastric Mucosa / Q000201:enzymology / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D011379:Prognosis; D011446:Prospective Studies; D012799:Sialyltransferases / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D015996:Survival Rate; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase; D000094663:beta-Galactoside alpha-2,3-Sialyltransferase
D012799:Sialyltransferases; D000094802:beta-D-Galactoside alpha 2-6-Sialyltransferase; D000094663:beta-Galactoside alpha-2,3-Sialyltransferase; C000722087:ST3GAL1 protein, human