Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels.
Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.
D000293:Adolescent; D002878:Chromosomes, Human, Pair 1; D002896:Chromosomes, Human, Pair 6; D008040:Genetic Linkage; D006801:Humans; D008074:Lipoproteins / Q000235:genetics*; D040641:Quantitative Trait Loci; D014427:Twins / Q000235:genetics*; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
D008074:Lipoproteins