title: Prophylactic laser treatment in early age-related maculopathy: an 8-year follow-up in a randomized pilot study shows a reduced incidence of exudative complications.
abstract: OBJECTIVE
  To study the effect of mild laser treatment on the incidence of exudative complications in patients with soft drusen maculopathy in a longterm perspective.
  
  
  METHODS
  In a prospective study, 38 patients with early age-related maculopathy and good visual acuity (VA) were randomized either to laser treatment using an argon green laser or to observation. At 8 years, 29 patients remained in the study, 16 in the control group and 13 in the treatment group.
  
  
  RESULTS
  During follow-up, mean VA decreased significantly in both groups, to 0.53 in the treatment group (p < 0.05) and to 0.25 in the control group (p < 0.001). At 8 years, 9/16 in the control group showed exudative complications, whereas only 2/13 in the treatment group developed such changes (p < 0.03).
  
  
  CONCLUSIONS
  In this randomized pilot study, mild laser treatment of soft drusen maculopathy significantly reduced the rate of exudative complications in a longterm perspective. As the study is small, the results should be viewed with caution.
mesh_terms: D000368:Aged; D002829:Choroid / Q000098:blood supply; D005122:Exudates and Transudates; D005128:Eye Diseases / Q000517:prevention & control*; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy; D008268:Macular Degeneration / Q000150:complications / Q000503:physiopathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000209:etiology; D010865:Pilot Projects; D011315:Preventive Medicine / Q000379:methods*; D012163:Retinal Detachment / Q000209:etiology; D014792:Visual Acuity