Tricin from a malagasy connaraceous plant with potent antihistaminic activity.
The bioassay-guided separation of a Malagasy plant, Agelaea pentagyna, led to the isolation of a flavonoid, tricin (1), with potent inhibitory activity toward exocytosis from antigen-stimulated rat leukemia basophils (RBL-2H3). The structure-activity relationships among structurally related natural and synthetic flavonoids are also discussed.
D000818:Animals; D001491:Basophils / Q000187:drug effects; D031961:Connaraceae / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006634:Histamine H1 Antagonists / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007938:Leukemia; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D013329:Structure-Activity Relationship
D005419:Flavonoids; D006634:Histamine H1 Antagonists; C017769:tricin