[Comparative analysis of the antioxidant system of mouse liver and blood during exposure to toxins, extracted from drinking water].
A comparative analysis of the antioxidant system of mouse liver and blood was done during one month after a single per os administration of oil solutions of hexane--ether extracts from the drinking water sources with different proportions of benz(o)pyrene and polychlorbiphenyls. The absence of a linear dependence dose-effect on the extract concentration and a change in the scale and direction of interrelations between the parameters examined (the antioxidant activity of lipids, the content of peroxides, and the content of products interacting with 2-thiobarbituric acid) were revealed, indicating a high sensitivity and the absence of normalization of the antioxidant status in animal tissues.
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001564:Benzo(a)pyrene / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D014881:Water Supply / Q000032:analysis*
D000975:Antioxidants; D001564:Benzo(a)pyrene; D011078:Polychlorinated Biphenyls