Defining control: regulation of dendritic cell activation and immune homeostasis by SOCS1.
SOCS1 is a key regulator of cytokine signaling and is important for maintaining balance in the immune system. In addition to roles in T, NKT, and macrophage cell function, a new study indicates that SOCS1 modulates dendritic cell activation and may help prevent autoimmunity.
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology*; D007107:Immune System / Q000378:metabolism*; D051379:Mice; D012097:Repressor Proteins; D015398:Signal Transduction / Q000502:physiology; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins
D002352:Carrier Proteins; D016207:Cytokines; D012097:Repressor Proteins; C491590:Socs1 protein, mouse; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins