title: Palladium-catalyzed H-D exchange into nucleic acids in deuterium oxide.
abstract: We have developed an efficient and extensive deuterium incorporation method using a heterogeneous Pd/C-D2O-H2 system into the base moiety of nucleic acids. The results presented here provide a deuterium gas-free, totally catalytic and post-synthetic deuterium labeling method in D2O media.
mesh_terms: D002384:Catalysis; D003903:Deuterium / Q000737:chemistry*; D017666:Deuterium Oxide / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D009696:Nucleic Acids / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D009696:Nucleic Acids; D010165:Palladium; D006859:Hydrogen; D003903:Deuterium; D017666:Deuterium Oxide