[Effect of pingchuan mixture on eosinophil cation protein and interleukin-5 in experimental guinea pigs with asthma].
OBJECTIVE
To observe the effect of Pingchuan Mixture (PCM) on plasma eosinophil cation protein (ECP), interleukin-5 in bronchial alveolar lavage fluid (BALF) and inflammatory cell count in experimental guinea pigs with asthma.


METHODS
The eosinophil, neutrophil, lymphocyte count were conducted by conventional method, IL-5 was detected by ELISA and ECP determined by RIA.


RESULTS
Levels of eosinophil, neutrophil, lymphocyte, ECP and IL-5 after treatment were significantly lower than those before treatment, the difference between groups treated respectively by PCM, aminophylline, dexamethasone and Dingchuan Zhike Tablet was insignificant.


CONCLUSIONS
PCM could treat asthma by reducing the inflammatory cell count, ECP and IL-5.
D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000378:metabolism*; D006168:Guinea Pigs; D015848:Interleukin-5 / Q000378:metabolism*; D010047:Ovalbumin; D012260:Ribonucleases / Q000378:metabolism*
D001798:Blood Proteins; D004365:Drugs, Chinese Herbal; D047091:Eosinophil Granule Proteins; D015848:Interleukin-5; D010047:Ovalbumin; D012260:Ribonucleases