title: Structure and functions of tumor necrosis factor-alpha converting enzyme.
abstract: Tumor necrosis factor-alpha converting enzyme (TACE) is the first described and best characterized secretase. In this review the structure and the possible roles for TACE are summarized. The substrate specificity and the regulation of TACE activity as well as redundancy and possible cooperations of distinct secretases are also discussed.
mesh_terms: D051722:ADAM Proteins; D000072198:ADAM17 Protein; D000818:Animals; D004789:Enzyme Activation / Q000502:physiology; D008666:Metalloendopeptidases / Q000235:genetics / Q000378:metabolism*; D045726:Metalloproteases / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D017433:Protein Structure, Secondary / Q000235:genetics / Q000502:physiology; D013379:Substrate Specificity / Q000502:physiology
chemical_list: D045726:Metalloproteases; D051722:ADAM Proteins; D008666:Metalloendopeptidases; D000072198:ADAM17 Protein; C000606463:Adam17 protein, mouse