Tackling an essential problem in functional proteomics of Saccharomyces cerevisiae.
Gene inactivation is the cornerstone of functional genetic analysis, but the analysis of essential genes requires conditional inactivation of the gene product. A new study has adapted a simple method for creating conditional alleles to allow large-scale analysis of essential genes in Saccharomyces cerevisiae and has identified a role in DNA replication for a newly identified protein complex.
D004261:DNA Replication; D005656:Fungal Proteins / Q000235:genetics* / Q000378:metabolism*; D020043:Genes, Essential / Q000235:genetics / Q000502:physiology*; D018816:Genes, cdc / Q000502:physiology; D040901:Proteomics / Q000379:methods*; D012441:Saccharomyces cerevisiae / Q000235:genetics*
D005656:Fungal Proteins