Omental transposition to the brain as a surgical method for treating Alzheimer's disease.
The purpose of this study was to learn the effect of omental transposition to the brain of patients who exhibited the most serious effects of long-standing Alzheimer's disease. Ten patients who had extremely low Mini Mental-State Examination scores of 2-14 underwent placement of their elongated pedicled omentum onto their left parietal-temporal cerebral cortex. Patients underwent pre- and post-operative MRI and SPECT scans in addition to long-term neurological and neuropsychological testing. All were followed up to one year. In spite of the patients' severe cognitive and functional disability, several of the patients demonstrated subjective and objective improvement, especially in terms of their functional status.
D000203:Activities of Daily Living; D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D001284:Atrophy / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D002540:Cerebral Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology*; D002548:Cerebral Revascularization / Q000379:methods*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009852:Omentum / Q000098:blood supply* / Q000637:transplantation*; D011788:Quality of Life; D020127:Recovery of Function / Q000502:physiology; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome