Stevens-Johnson syndrome/toxic epidermal necrolysis in a patient receiving concurrent radiation and gemcitabine.
A patient with stage IV malignant melanoma treated with daily radiotherapy and low-dose (100 mg/m2) daily gemcitabine developed a blistering skin eruption, fever and neutropenia consistent with overlap Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). The diagnosis was confirmed by skin biopsy of an affected area. The case history is described, and the literature relating to the development of SJS/TEN in association with chemotherapy and radiotherapy administration is reviewed. This report describes a serious potential complication of concurrent gemcitabine and radiotherapy.
D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008545:Melanoma / Q000188:drug therapy / Q000532:radiotherapy*; D008875:Middle Aged; D011859:Radiography; D012878:Skin Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced* / Q000209:etiology*; D000093542:Gemcitabine
D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000093542:Gemcitabine