[Allogenic small intestine transplantation in the rat model with initial CsA therapy: first detection of Th2-induced immune tolerance].
It is not clear how initial therapy with CsA effects indefinite allograft acceptance after small bowel transplantation in the rat. Our study of post-transplant alterations of immune parameters within donor-type mesenteric lymph nodes suggests CsA-dependent, Th2-mediated induction of graft-specific T-cell tolerance.
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology*; D015536:Down-Regulation; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007421:Intestine, Small / Q000276:immunology / Q000637:transplantation*; D008198:Lymph Nodes / Q000276:immunology; D018655:Lymphocyte Count; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D016176:T-Lymphocyte Subsets / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology*; D014157:Transcription Factors / Q000276:immunology; D023001:Transplantation Tolerance / Q000187:drug effects* / Q000276:immunology; D016042:Transplantation, Heterotopic / Q000276:immunology
D007166:Immunosuppressive Agents; C503773:LF-A1 protein, rat; D014157:Transcription Factors; D016572:Cyclosporine