title: Improved bactericidal activity of silver-loaded zirconium phosphate in the presence of Cl- by combining with hydroxyapatite.
abstract: Silver-loaded zirconium phosphate (AgZ) was combined with hydroxyapatite (HA) to prepare an antibacterial composite (AgZ/HA) with improved activity in the presence of Cl-. When Escherichia coli cells were deactivated in 154 mM NaCl, the bacterial survival ratio at 90 min for AgZ/HA was 3.9 x 10(-4) compared to 1.2 x 10(-1) for AgZ itself. Because the bactericidal activity of AgZ/HA decreased with increasing phosphate ion up to 10 mM, cell adsorption onto the combined HA moiety probably compensated for the Cl- -induced deterioration in the activity of the silver-based bactericide.
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002713:Chlorine / Q000737:chemistry / Q000494:pharmacology*; D004357:Drug Synergism; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000254:growth & development*; D012834:Silver / Q000737:chemistry / Q000494:pharmacology*; D013242:Sterilization / Q000379:methods; D015040:Zirconium / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; C027006:zirconium phosphate; D012834:Silver; D002713:Chlorine; D017886:Durapatite; D015040:Zirconium