Primary malignant lymphoma of the trigeminal region treated with rapid infusion of high-dose MTX and radiation: case report and review of the literature.
BACKGROUND
Extra-axial primary CNS lymphoma, considered rare, mainly arise in the white matter of the brain. Though the tumor responds well to radiation and chemotherapy, the prognosis of primary CNS lymphoma remains poor. We report a case of primary lymphoma of Meckel's cave mimicking a trigeminal schwannoma radiographically, which achieved complete remission through use of rapid high-dose MTX therapy and radiation therapy.


METHODS
The patient, a 55-year-old Japanese male, presented left trigeminal neuralgia. Magnetic resonance imaging (MRI) revealed a mass lesion in the left side of Meckel's cave, with extension into the cerebellopontine angle and the infratemporal fossa through the foramen ovale, suggesting trigeminal schwannoma. However, the patient suffered radiologically inexplicable progressive cranial nerve palsy, which suggested malignant disease. MRI and CSF disclosed malignant tumor dissemination; biopsy revealed malignant lymphoma. The treatment, composed of the rapid infusion of high-dose MTX and whole brain and spine radiation, resulted in complete remission.


CONCLUSIONS
This case, which included atypical presentation of malignant lymphoma, illustrates the importance of including malignant lymphoma in the differential diagnosis of CP-angle and Meckel's cave tumor. The results also confirmed the usefulness of combined rapid high-dose MTX therapy and radiation.
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D016371:Cranial Irradiation; D003390:Cranial Nerve Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy*; D004334:Drug Administration Schedule; D006801:Humans; D007262:Infusions, Intravenous; D008223:Lymphoma / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage*; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D013131:Spine / Q000528:radiation effects; D016896:Treatment Outcome; D020433:Trigeminal Nerve Diseases / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy*; D014277:Trigeminal Neuralgia / Q000209:etiology*
D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate