High prevalence of MMTV-like env gene sequences in gestational breast cancer.
Gestational breast cancer (BC) is generally associated with rapid growth and increased mortality. Because the presence of MMTV-like sequences in BC has been associated with laminin receptor expression, a marker of poor prognosis, gestational BCs were analyzed for MMTV env gene-like sequences to explore whether MMTV-like sequences were also associated with its adverse outcome. Whereas 30-38% of sporadic BC have the sequences, in gestational BC the prevalence is 62%. We suggest that hormonal response elements present in the MMTV-like LTR may play a role in promoting cell growth, as they do in the mouse system.
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics / Q000821:virology*; D044584:Carcinoma, Ductal / Q000235:genetics / Q000821:virology*; D004273:DNA, Neoplasm; D005260:Female; D015752:Genes, env / Q000235:genetics*; D006728:Hormones / Q000494:pharmacology; D006801:Humans; D007774:Lactation; D008324:Mammary Tumor Virus, Mouse / Q000235:genetics*; D051379:Mice; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011247:Pregnancy; D011379:Prognosis; D020218:Response Elements; D020079:Terminal Repeat Sequences / Q000235:genetics
D004273:DNA, Neoplasm; D006728:Hormones