The COP9 signalosome: an alternative lid for the 26S proteasome?
Two groups have recently reported ubiquitin-deconjugating activities associated with the COP9 signalosome (CSN). Together with a previously identified deneddylation activity, CSN now appears to possess biochemical activities towards the cullin-containing ubiquitin ligases (e.g. deneddylation) and ubiquitinated protein substrates in the proteasome-mediated degradation processes (e.g. deubiquitination). Here, we discuss how these findings support a central role for CSN in ubiquitination of substrate proteins and their proteolysis
D017360:Arabidopsis / Q000378:metabolism; D000075686:COP9 Signalosome Complex; D044842:Cullin Proteins / Q000378:metabolism; D006801:Humans; D046912:Multiprotein Complexes; D010447:Peptide Hydrolases / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D011506:Proteins / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism
D044842:Cullin Proteins; D046912:Multiprotein Complexes; D011506:Proteins; D025801:Ubiquitin; D010447:Peptide Hydrolases; D000075686:COP9 Signalosome Complex; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease