title: QSAR of chemical polarizability and nerve toxicity. 2.
abstract: Polarizability is a property of molecules that has long been of interest to scientists from a variety of viewpoints. However, in the area of the QSAR of chemical-biological interactions, it has received little attention. Recently we have shown that one can use the simple summation of the valence electrons (H = 1, C = 4, O = 6, etc.) in a molecule as a measure of its polarizability. We have found this parameter to correlate nerve toxicity of a wide variety of chemicals acting on nerves of frogs, rabbits, cockroaches, and humans.
mesh_terms: D000818:Animals; D001001:Anura; D001463:Barbiturates / Q000737:chemistry / Q000633:toxicity; D003058:Cockroaches; D005260:Female; D006801:Humans; D051379:Mice; D008956:Models, Chemical; D009420:Nervous System / Q000187:drug effects*; D009498:Neurotoxins / Q000737:chemistry* / Q000633:toxicity*; D021281:Quantitative Structure-Activity Relationship; D011817:Rabbits
chemical_list: D001463:Barbiturates; D009498:Neurotoxins