Photochemical ligation of DNA "words" for DNA computing.
The photochemical DNA computing of 5-vinyluracil ((V)U) containing oligodeoxynucleotides (ODNs) tethered multiple "DNA words" is demonstrated. A new MARK and UNMARK operation based on the (V)U mediated reversible DNA photoligation has been developed for multiple-word DNA computing. The utility of this operation for DNA computing is demonstrated by solving a small Satisfiability problem (SAT problem) in which information was encoded in three tandem words.
D019295:Computational Biology; D004247:DNA / Q000737:chemistry*; D010777:Photochemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D004247:DNA