Cryptococcal meningitis in AIDS.
A study was carried out to determine the incidence of Cryptococcus species in AIDS patients and their susceptibility pattern to the different antifungal drugs used for therapy. PCR as a rapid diagnostic tool for cryptococcal meningitis was evaluated. All the isolates were senstive to the three antifungal drugs tested indicating that the development of drug resistance is not a major problem in the treatment of cryptococcosis. All the culture positive specimens were positive by PCR which can be evolved into a very useful, rapid diagnostic tool to detect cryptococci in clinical specimens.
D017088:AIDS-Related Opportunistic Infections / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D003455:Cryptococcus neoformans / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D016919:Meningitis, Cryptococcal / Q000134:cerebrospinal fluid* / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D008826:Microbial Sensitivity Tests / Q000379:methods; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D016896:Treatment Outcome
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole