Detection of the C-C mismatched base pair by small ligands.
We synthesized 2-aminonaphthyridine derivatives that specifically bind to cytosine-cytosine (C-C) mismatch. The binding of ligands was verified by observing an increase of melting temperature for 11-mer duplexes containing a mismatch in the presence of ligands. It was found that the aminonaphthyridine dimer stabilized C-C mismatch more strongly than the monomer.
D020137:Base Pair Mismatch; D001483:Base Sequence; D019281:Dimerization; D008024:Ligands; D009287:Naphthyridines / Q000737:chemistry
D008024:Ligands; D009287:Naphthyridines