title: Solid-phase synthesis of C-terminal modified peptides.
abstract: Solid-phase synthesis of biomolecules, of which peptides are the principal example, is well established. However, synthetic peptides containing modifications at the carboxy termini are often desired because of their potential therapeutic properties. As a result, there is a necessity for effective solid-phase strategies for the preparation of peptides with C-terminal end groups other than the usual carboxylic acid and carboxamide functionalities. The present article primarily reviews literature reports on methods for solid-phase synthesis of C-terminal modified peptides. In addition, general information about biological activities and/or synthetic applications of each individual class of peptide is also provided.
mesh_terms: D000438:Alcohols / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D000577:Amides / Q000737:chemistry; D000813:Anilides / Q000737:chemistry; D002625:Chemistry, Organic; D003374:Coumarins / Q000737:chemistry; D006834:Hydrazines / Q000737:chemistry; D006877:Hydroxamic Acids / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D008956:Models, Chemical; D055601:Organic Chemistry Phenomena; D010452:Peptide Biosynthesis; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D017434:Protein Structure, Tertiary
chemical_list: D000438:Alcohols; D000447:Aldehydes; D000577:Amides; D000813:Anilides; D003374:Coumarins; D006834:Hydrazines; D006877:Hydroxamic Acids; D007659:Ketones; D010455:Peptides; C030123:coumarin