[Effect of high dosage immunoglobulins on the function of rat hearts in xenoperfusion with human blood].
The application of high-dose immunoglobulins during xenoperfusion of the isolated rat heart resulted in a significantly higher pressure and heart rate. The coronary flow was also elevated as compared to untreated controls. The heart function during xenoperfusion without treatment was reduced to 50% of the baseline values within 11 min. With immunoglobulin treatment the occurrence of this deficit was delayed to 30 min. A concentrate of immunoglobulins was able to reduce the early functional damage of xenoperfused hearts by interfering with complement related graft destruction.
D000017:ABO Blood-Group System / Q000276:immunology; D000818:Animals; D001769:Blood / Q000276:immunology*; D003326:Coronary Circulation / Q000276:immunology*; D006085:Graft Survival / Q000276:immunology; D006339:Heart Rate / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000494:pharmacology*; D007075:Immunoglobulin M / Q000494:pharmacology*; D007136:Immunoglobulins / Q000494:pharmacology*; D010477:Perfusion; D051381:Rats; D017207:Rats, Sprague-Dawley; D014183:Transplantation, Heterologous / Q000276:immunology*; D016277:Ventricular Function, Left / Q000276:immunology*
D000017:ABO Blood-Group System; D007070:Immunoglobulin A; D007075:Immunoglobulin M; D007136:Immunoglobulins; C060166:pentaglobulin