[Antithrombotic and thrombolytic effectiveness of rhirudin in mcrovessels].
Using the thrombosis model of the hairless mouse ear, we demonstrate that intravenous application of hirudin significantly delays thrombus formation and increases the rate of vessel recanalization, thus, supporting its use in clinical microvascular surgery.
D000818:Animals; D004431:Ear, External / Q000098:blood supply*; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006629:Hirudins / Q000494:pharmacology*; D051379:Mice; D008812:Mice, Hairless; D008833:Microcirculation / Q000187:drug effects* / Q000503:physiopathology; D011994:Recombinant Proteins / Q000494:pharmacology; D013927:Thrombosis / Q000503:physiopathology*; D016896:Treatment Outcome
D005343:Fibrinolytic Agents; D006629:Hirudins; D011994:Recombinant Proteins