title: Conjugation of poor inhibitors with surface binding groups: a strategy to improve inhibition.
abstract: Conjugation of surface binding groups with inhibitors for carbonic anhydrase leads to the conversion of weak inhibitors to strong inhibitors.
mesh_terms: D001667:Binding, Competitive; D002257:Carbonic Anhydrase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D002256:Carbonic Anhydrases / Q000378:metabolism; D002384:Catalysis; D006639:Histidine / Q000737:chemistry*; D007700:Kinetics; D019216:Metals, Heavy / Q000737:chemistry / Q000378:metabolism; D008956:Models, Chemical; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D019216:Metals, Heavy; D009942:Organometallic Compounds; D013449:Sulfonamides; D006639:Histidine; D002256:Carbonic Anhydrases