title: Xpd, a structural bridge and a functional link.
abstract: Xpd, one of nine polypeptide subunits of the general transcription factor TFIIH plays an organizing role in TFIIH assembly. This structural function in protein complex assembly appears to be used by cells in a dynamic way to regulate and co-ordinate the diverse cellular functions of the different sub-complexes in transcription, DNA repair and cell cycle progression.
mesh_terms: D004265:DNA Helicases; D004260:DNA Repair; D004268:DNA-Binding Proteins; D006801:Humans; D046911:Macromolecular Substances; D008938:Mitosis / Q000502:physiology; D009154:Mutation; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism*; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D051758:Transcription Factor TFIIH; D014157:Transcription Factors; D019473:Transcription Factors, TFII / Q000737:chemistry / Q000378:metabolism*; D014158:Transcription, Genetic; D051759:Xeroderma Pigmentosum Group D Protein
chemical_list: D004268:DNA-Binding Proteins; D046911:Macromolecular Substances; D021122:Protein Subunits; D011506:Proteins; D014157:Transcription Factors; D019473:Transcription Factors, TFII; D051758:Transcription Factor TFIIH; D004265:DNA Helicases; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human