title: [Calculated antibiotic therapy in gastroenterologic infections].
abstract: In gastroenterologic infections a calculated antibiotic therapy is not only determined by the suspected variety of bacterials usually associated with given symptoms but also by considerations of their potential side effects, pharmaokinetics and penetration as well as an assessment of the immune status of the patient. As some antibiotic combinations show synergistic activity whereas others are antagonistic or result in accumulated toxicity, this manuscript presents the antimicrobial profile of clinically important antibiotics including their side effects, kinetics, penetration and possible combinations. From these data recommendations for a rational and calculated antibiotic therapy of gastrointestinal infections are developed taking the guidelines of the respective scientific societies into consideration.
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005767:Gastrointestinal Diseases / Q000188:drug therapy* / Q000382:microbiology*; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008712:Methicillin / Q000494:pharmacology; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D012307:Risk Factors; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D008712:Methicillin