Regulation of [Ca2+]c oscillations by plasma membrane Ca2+ fluxes: a role for natriuretic peptides.
We have investigated the effects of natriuretic peptides on oscillations in [Ca(2+)](c) (cytosolic free Ca(2+) concentration) in two different cell types: freshly isolated rat hepatocytes and the ECV304 cell line. Our data, from both cell types, suggest that natriuretic peptides modulate the frequency of [Ca(2+)](c) oscillations through alterations in plasma membrane Ca(2+) fluxes. Here, we review evidence for a role for plasma membrane Ca(2+) fluxes in the control of the frequency of [Ca(2+)](c) oscillations. We describe a hypothetical mechanism through which this might be achieved. We propose a physiological role for regulated control of Ca(2+) efflux in modulating [Ca(2+)](c) oscillations.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D002478:Cells, Cultured; D003600:Cytosol / Q000378:metabolism; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D045265:Natriuretic Peptides / Q000737:chemistry*; D009991:Oscillometry; D051381:Rats; D015398:Signal Transduction
D045265:Natriuretic Peptides; D002118:Calcium