[Preparation of acyclovir liposome and study on its stability].
OBJECTIVE
To prepare acyclovir liposome for improvement the entrapment efficiency and stability.


METHODS
Acyclovir liposome was prepared by the reverse evaporating method. Surfactants such as sodium deoxycholate and oleic acid were added to optimize the conditions and technology of preparing acyclovir liposome. The entrapment efficiency and particle size of the acyclovir liposome were determined. The liposome stability was proved by centrifugal acceleration experiment.


RESULTS
The particle size of the acyclovir liposome was 219.8 nm with the polydispersity index of 0.158. The entrapment efficiency reached 65%. The liposome was stable.


CONCLUSIONS
The results suggest that the conditions and technology are stable and practical to prepare the liposome with high entrapment efficient and stability.
D000212:Acyclovir / Q000008:administration & dosage*; D000998:Antiviral Agents / Q000008:administration & dosage*; D004337:Drug Carriers; D004355:Drug Stability; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D013678:Technology, Pharmaceutical / Q000379:methods*
D000998:Antiviral Agents; D004337:Drug Carriers; D008081:Liposomes; D000212:Acyclovir