Multiple opportunistic AIDS-associated disorders strictly related to immunodeficiency levels, in a girl with congenital HIV infection.
A 16-year-old girl with vertical HIV disease treated since birth suffered from six different AIDS-defining disorders until now. Even during the highly active antiretroviral therapy, multiple AIDS-related opportunistic infections may complicate the course of long-term congenital HIV disease, showing a strict relationship with immunological deterioration, which occurs shortly after virologic failure, due to an extensive genotypic resistance to all available antiretroviral compounds.
D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000276:immunology; D000293:Adolescent; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D002180:Candidiasis, Oral / Q000150:complications; D017726:Cytomegalovirus Retinitis / Q000150:complications; D024882:Drug Resistance, Viral; D005260:Female; D005759:Gastroenteritis / Q000150:complications; D015658:HIV Infections / Q000150:complications / Q000151:congenital* / Q000276:immunology; D006562:Herpes Zoster / Q000150:complications; D006801:Humans; D011020:Pneumonia, Pneumocystis / Q000150:complications; D012480:Salmonella Infections / Q000150:complications; D018805:Sepsis / Q000150:complications; D016781:Toxoplasmosis, Cerebral / Q000150:complications