[Modification of immune response after polytrauma and cardiopulmonary bypass by hematopoietic growth factors].
Cardiac surgery and polytrauma result in an impaired immune response as it can be demonstrated by a reduced endotoxin-stimulated TNF alpha production of whole blood cultures ex vivo. The immune-stimulating hematopoetic growth factor GM-CSF is in vitro capable to antagonize the suppressed immune function after trauma and cardiac surgery and, therefore, GM-CSF represents a potential therapeutic for immune suppressed states.
D002315:Cardiopulmonary Bypass; D004797:Enzyme-Linked Immunosorbent Assay; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D006331:Heart Diseases / Q000276:immunology / Q000601:surgery*; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D066298:In Vitro Techniques; D015850:Interleukin-6 / Q000097:blood*; D008070:Lipopolysaccharides / Q000276:immunology*; D009104:Multiple Trauma / Q000276:immunology*; D011994:Recombinant Proteins; D012475:Salmonella / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D015850:Interleukin-6; D008070:Lipopolysaccharides; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D016178:Granulocyte-Macrophage Colony-Stimulating Factor