Mechanisms of release of ATP from vascular purinergic nerves.
1. The vasoconstrictor response to periarterial nerve electrical stimulation (PNS) and neurotransmission by ATP are discussed and illustrated, using canine isolated and perfused splenic arterial preparations. 2. The conditions for appearance of dominant purinergic constrictor response to PNS are discussed. 3. Modulation of the purinergic vasoconstrictor responses to PNS by several kinds of presynaptic receptor agonists and antagonists is reviewed. 4. Influences of purinergic responses to PNS by guanethidine, reserpine, tetrodotoxin (TTX) or omega-conotoxin GVIA (omegaCTX) are also reviewed. 5. Effects of imipramine and removal of the endothelium are discussed. 6. Evidence is presented for selective inhibition of purinergic responses to PNS by an adequate cold storage of the vessel. 7. The roles of ATP released by PNS in isolated canine splenic arteries are proposed.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D008954:Models, Biological; D009131:Muscle, Smooth, Vascular / Q000294:innervation / Q000378:metabolism*; D009412:Nerve Fibers / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism; D011687:Purines / Q000378:metabolism
D018377:Neurotransmitter Agents; D011687:Purines; D000255:Adenosine Triphosphate; C030985:purine