title: Study on interaction of a cationic porphyrin with DNA.
abstract: 5,10,15,20-Tetra(N-methyl-pyridinium-4-yl)-21H,23H-porphyrin has shown to bind to the major groove of AT-rich DNA predominantly through electrostatic interaction between positively charged N-methyl pyridinium moieties of the porphyrin and negatively charged phosphodiester backbone. Solution structure of the complex between the porphyrin and a double-stranded DNA fragment has been inferred from the measurements of the mixing time-dependent intermolecular nuclear Overhauser effects (NOEs).
mesh_terms: D002412:Cations; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011166:Porphyrins / Q000737:chemistry*
chemical_list: D002412:Cations; D011166:Porphyrins; C021096:tetra(4-N-methylpyridyl)porphine; D004247:DNA