The effect of radiosurgery during management of aggressive meningiomas.
BACKGROUND
Aggressive (atypical or malignant) meningiomas are difficult tumors to manage. We review the local control and survival rates of patients with aggressive meningiomas after multi-modality therapy that included stereotactic radiosurgery (SRS).


METHODS
Thirty patients had SRS for treatment of malignant (n = 12) or atypical (n = 18) meningiomas. There were 17 (57%) males and 13 (43%) females with an average age of 58 years. The mean number of prior surgical resections was two. The median imaging follow-up was 2.3 (0.1-11.4) years; median clinical follow-up was 3.8 (0.25-11.5) years.


RESULTS
After SRS, the overall median time until progression of neurologic signs was 48.0 (+/-6.51) months. Median time to neurologic progression was significantly worse for patients treated late after recurrence versus early after craniotomy. Atypical meningiomas had 5- and 10-year overall actuarial survival rates of 59% (+/-13), while malignant meningiomas had 5- and 10-year overall actuarial survival rates of 59% (+/-16) and 0%. These curves were not significantly different from one another. Atypical meningiomas had a 5-year progression-free survival (PFS) of 83% (+/-7%), while malignant meningiomas had a 5-year PFS of 72% (+/-10) (p = 0.018). On multivariate analysis, early SRS and smaller tumor volumes were associated with better PFS, while younger age was associated with better survival. One patient had an adverse radiation effect after SRS.


CONCLUSIONS
Stereotactic radiosurgery is an important adjuvant management strategy for residual tumors identified early after craniotomy and partial resection. Aggressive use of early boost radiosurgery following craniotomy and radiation therapy is recommended for patients with malignant meningiomas.
D000206:Actuarial Analysis; D000328:Adult; D017024:Chemotherapy, Adjuvant; D003663:Decision Trees; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000145:classification / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy / Q000601:surgery*; D008579:Meningioma / Q000145:classification / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology / Q000532:radiotherapy / Q000601:surgery*; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D016634:Radiosurgery; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome