Churg-strauss syndrome with cholecystitis and renal involvement.
A patient with bronchial asthma developed cholecystitis. Laboratory investigations revealed marked eosinophilia (6,615/mm3), an elevated anti-neutrophil cytoplasmic antibody level and renal dysfunction (blood urea nitrogen 14 mg/dl, creatinine 1.4 mg/dl). Following cholecystectomy, histopathological examination revealed a marked inflammatory cell infiltrate composed mainly of eosinophils with evidence of invasion of the wall of the gall bladder and granuloma formation of arterioles. A diagnosis of Churg-Strauss syndrome was made and she was treated with 60 mg of prednisolone per day. A renal biopsy was performed one year later in view of persistent renal dysfunction. Pathological analysis revealed a pauci-immune glomerulonephritis with interstitial changes but no crescent formation.
D002764:Cholecystitis / Q000150:complications* / Q000601:surgery; D015267:Churg-Strauss Syndrome / Q000150:complications / Q000276:immunology*; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008875:Middle Aged