Identification and expression of Ima, a novel Ral-interacting Drosophila protein.
We report the identification of Ima, a novel Drosophila MAGUK-like protein, which contains two WW and four PDZ protein interaction domains and interacts with the small GTPase dRal in the yeast two-hybrid system and pull-down assays. The gene is expressed in distinct spatiotemporal patterns throughout embryonic development. Overexpression of Ima interferes with normal Drosophila development, indicating that the gene functions in a tissue specific manner.
D000818:Animals; D004330:Drosophila / Q000235:genetics; D029721:Drosophila Proteins / Q000378:metabolism; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D020798:Two-Hybrid System Techniques; D020725:ral GTP-Binding Proteins
D029721:Drosophila Proteins; D020725:ral GTP-Binding Proteins