Plasmodium falciparum multiplicity correlates with anaemia in symptomatic malaria.
In 366 Ghanaian children with symptomatic Plasmodium falciparum malaria, low haemoglobin levels and severe anaemia were associated with a high multiplicity of infection (MOI) and with distinct merozoite surface protein alleles. High MOI not only reflects premunition but may also contribute to anaemia in symptomatic malaria.
D000483:Alleles; D000740:Anemia / Q000469:parasitology*; D000818:Animals; D002675:Child, Preschool; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007223:Infant; D016778:Malaria, Falciparum / Q000097:blood / Q000469:parasitology*; D008297:Male; D010963:Plasmodium falciparum / Q000235:genetics / Q000302:isolation & purification; D015800:Protozoan Proteins / Q000032:analysis; D012044:Regression Analysis
D006454:Hemoglobins; D015800:Protozoan Proteins