title: An XML message broker framework for exchange and integration of microarray data.
abstract: BACKGROUND
  Microarrays are an important research tool for the advancement of basic biological sciences. However this technology has yet to be integrated with clinical decision making. We have implemented an information framework based on the Microarray Gene Expression Markup Language (MAGE-ML) specification. We are using this framework to develop a test-bed integrated database application to identify genomic and imaging markers for diagnosis of breast cancer.
  
  
  RESULTS
  We developed extensible software architecture for retrieving data from different microarray databases using MAGE-ML and for combining microarray data with breast cancer image analysis and clinical data for correlation studies. The framework we developed will provide the necessary data integration to move microarray research from basic biological sciences to clinical applications.
  
  
  BACKGROUND
  Open source software will be available from SourceForge (http://sourceforge.net/projects/microsoap/).
mesh_terms: D003628:Database Management Systems; D030541:Databases, Genetic; D019146:Hypermedia; D016247:Information Storage and Retrieval / Q000379:methods*; D020407:Internet; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012984:Software; D012985:Software Design; D018511:Systems Integration; D014584:User-Computer Interface