Interdependence of the contractile ring and spindle midzone in cleavage plane maintenance.
How segregation of the chromosomes is coordinated with the ensuing cell cleavage to complete the cell cycle is not well understood. A recent study of cytokinesis in fission yeast by Pardo and Nurse suggests that the contractile ring is required for assembly of the post-mitotic microtubule array (PAA). In turn, the PAA is required to maintain the contractile ring at the cleavage plane, as well as to keep the nuclei separated at the poles of the cleaving cell. These functions may be particularly important for a cell cycle checkpoint ensuring that if cytokinesis is delayed, septation will occur between the two daughter nuclei.
D000199:Actins / Q000378:metabolism; D000818:Animals; D002455:Cell Division / Q000502:physiology*; D002875:Chromosomes / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism; D012568:Schizosaccharomyces / Q000166:cytology / Q000378:metabolism; D008941:Spindle Apparatus / Q000378:metabolism*
D000199:Actins