[Effects of ibandronate on the osteopenia process in tail-suspended rats].
Histological and histomorphometric effects of ibandronate on the metaphyseal spongiosis in tibia were studied in tail-suspended rats and their controls in a 30-d experiment. Ten- to twenty-day course of ibandronate at a dose of 6 micrograms/kg of the body mass per diem altered the architectonics of metaphyseal spongiosis and increased materially the total spongiosis volume no matter whether those were suspended rats or controls. Spongiosis growth was a result of a sharp deterioration of resorption and spongy bone remodelling due to ibandronate. The substance also exhibited a strong durable action inferring that it might be used for prevention of osteopenia for lack of loading on the musculoskeletal system.
D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D001851:Bone Diseases, Metabolic / Q000209:etiology / Q000517:prevention & control*; D016723:Bone Remodeling; D001862:Bone Resorption; D003627:Data Interpretation, Statistical; D004164:Diphosphonates / Q000008:administration & dosage / Q000494:pharmacology*; D019417:Hindlimb Suspension; D000077557:Ibandronic Acid; D008297:Male; D051381:Rats; D013950:Thymus Gland / Q000187:drug effects; D013977:Tibia / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D014893:Weightlessness / Q000009:adverse effects*
D004164:Diphosphonates; D000077557:Ibandronic Acid