Adiabatic pumping mechanism for ion motive ATPases.
An ion motive ATPase is a membrane protein that pumps ions across the membrane at the expense of the chemical energy of adenosine triphosphate (ATP) hydrolysis. Here we describe how an external electric field, by inducing transitions between several protein configurations, can also power this pump. The underlying mechanism may be very similar to that of a recently constructed adiabatic electron pump [Science 283, 1905 (1999)]].
Astumian
R Dean
RD
University of Maine, Orono, Maine 04469-5709, USA. astumian@maine.edu
D000251:Adenosine Triphosphatases / Q000737:chemistry* / Q000378:metabolism*; D001693:Biological Transport, Active; D016623:Ion Pumps / Q000737:chemistry* / Q000378:metabolism*; D008956:Models, Chemical; D011487:Protein Conformation; D013816:Thermodynamics
D016623:Ion Pumps; D000251:Adenosine Triphosphatases