An enantioselective synthesis of the C(33)-C(37) fragment of Amphotericin B.
An enantioselective synthesis of the C(33)-C(37) tripropionate fragment of Amphotericin B has been developed in only 6 steps.
Karisalmi
Kaisa
K
Laboratory of Organic Chemistry, Helsinki University of Technology, Kemistilntie 1, PO Box 6100, Fin-02015 HUT Espoo, Finland.
Rissanen
Kari
K
Koskinen
Ari M P
AM
D000666:Amphotericin B / Q000138:chemical synthesis* / Q000737:chemistry*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D004952:Esters; D008024:Ligands; D008956:Models, Chemical; D008958:Models, Molecular; D013237:Stereoisomerism; D013302:Streptomyces / Q000378:metabolism
D000935:Antifungal Agents; D004952:Esters; D008024:Ligands; D000666:Amphotericin B