title: Safety and immunogenicity of DNA/modified vaccinia virus ankara malaria vaccination in African adults.
abstract: The present study is an investigation of the safety and immunogenicity of DNA and modified vaccinia virus Ankara (MVA) candidate vaccines, each encoding the malaria DNA sequence multiple epitope-thrombospondin related adhesion protein (ME-TRAP), against Plasmodium falciparum. DNA ME-TRAP and MVA ME-TRAP are safe and immunogenic for effector and memory T cell induction. MVA ME-TRAP, with or without prior DNA ME-TRAP immunization, was more immunogenic and more cross-reactive in malaria-exposed individuals than in malaria-naive individuals, a finding suggesting that recombinant MVA vaccines are particularly promising for the development of a malaria vaccine for exposed populations. Both CD4(+) and CD8(+) T cells were induced by these vaccines.
authors.affiliation: Medical Research Council Laboratories, Banjul, The Gambia.
authors.forename: Vasee S
authors.initials: VS
authors.lastname: Moorthy
authors.forename: Margaret
authors.initials: M
authors.lastname: Pinder
authors.forename: William H H
authors.initials: WH
authors.lastname: Reece
authors.forename: Kate
authors.initials: K
authors.lastname: Watkins
authors.forename: Sowsan
authors.initials: S
authors.lastname: Atabani
authors.forename: Carolyn
authors.initials: C
authors.lastname: Hannan
authors.forename: Kalifa
authors.initials: K
authors.lastname: Bojang
authors.forename: Keith P W J
authors.initials: KP
authors.lastname: McAdam
authors.forename: Joerg
authors.initials: J
authors.lastname: Schneider
authors.forename: Sarah
authors.initials: S
authors.lastname: Gilbert
authors.forename: Adrian V S
authors.initials: AV
authors.lastname: Hill
mesh_terms: D000328:Adult; D000349:Africa; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007115:Immunization Schedule; D008213:Lymphocyte Activation; D017780:Malaria Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*; D016778:Malaria, Falciparum / Q000276:immunology / Q000517:prevention & control; D010963:Plasmodium falciparum / Q000276:immunology; D015800:Protozoan Proteins / Q000235:genetics / Q000276:immunology; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*; D014616:Vaccinia virus / Q000235:genetics*
chemical_list: D017780:Malaria Vaccines; D015800:Protozoan Proteins; D019444:Vaccines, DNA; C069428:thrombospondin-related adhesive protein, protozoan