title: Hypercalciuria in osteogenesis imperfecta type I.
abstract: BACKGROUND
  In Osteogenesis Imperfecta severity of disease and reduced physical activity have been considered the main factors contributing to hypercalciuria; however, its pathogenesis in Osteogenesis Imperfecta Type I, in which mobility is normal, is still unclear.
  
  
  METHODS
  We describe a patient with Osteogenesis Imperfecta Type I and hypercalciuria, in whom measurement of calcium intake, plasma 1 - 25(OH) (2) Vitamin D, fasting calciuria and tubular proteinuria led us to exclude an absorptive or renal component in the pathogenesis of hypercalciuria.
  
  
  CONCLUSIONS
  We believe that hypercalciuria is determined by bone disease in Osteogenesis Imperfecta Type I. This condition should be added to the causes of normocalcemic hypercalciuria in children and the mildest forms should be differentiated from Idiopathic Hypercalciuria.
authors.affiliation: Department of Pediatrics, University of Parma School of Medicine, Parma, Italy. anitason@unipr.it
authors.forename: A
authors.initials: A
authors.lastname: Ammenti
authors.forename: M
authors.initials: M
authors.lastname: Nitsch
mesh_terms: D000367:Age Factors; D000469:Alkaline Phosphatase / Q000097:blood; D002118:Calcium / Q000097:blood / Q000652:urine*; D002675:Child, Preschool; D005215:Fasting; D006801:Humans; D008297:Male; D010013:Osteogenesis Imperfecta / Q000145:classification / Q000150:complications* / Q000175:diagnosis / Q000652:urine; D011507:Proteinuria / Q000175:diagnosis
chemical_list: D000469:Alkaline Phosphatase; D002118:Calcium