Association of HLA class I alleles with psoriasis vulgaris in southeastern Chinese Hans.
BACKGROUND
Predisposing genetic factors in psoriasis include associations with human leukocyte antigen (HLA). Accumulative evidence has shown that certain HLA at class I locus, especially HLA-Cw6, are associated closely with psoriasis.


OBJECTIVE
To evaluate the association of HLA class I alleles with susceptibility to psoriasis in the southeastern Chinese Han population.


METHODS
We performed genotype for HLA-A, -B and -C loci in 166 patients with psoriasis vulgaris by means of polymerase chain reaction with sequence-specific primers technique. The distribution of HLA allelic frequencies was further analyzed according to age of onset, i.e. under 35-y and beyond 35-y groups. These data were compared with the healthy controls of 204 unrelated Hans.


RESULTS
The frequencies of HLA-A*26 (24.7% vs. 13.1%, OR=2.36, Pc<0.01), -B*13 (27.2% vs. 14.8%, OR=2.34, Pc<0.01), -B*27 (12.2% vs. 4.0%, OR=3.49, Pc<0.01) and -Cw*0602 (17.9% vs. 5.3%, OR=4.20, Pc<0.001) were significantly increased in psoriasis patients, whereas HLA-Cw*0304 frequency (4.9% vs. 13.4%, OR=0.32, Pc<0.01) was highly decreased, when compared to the controls. HLA-A*26-B*27-Cw*0602 was identified as a high-risk haplotype of HLA class I in developing psoriasis in the test. HLA-Cw*0602 was found to be strongly associated with the early-onset psoriasis (age of onset <35 y).


CONCLUSIONS
This study demonstrated the positive associations of HLA class I markers with psoriasis vulgaris, of which HLA-Cw*0602 was the strongest susceptibility determinant for development of early-onset psoriasis, in the southeastern Chinese Han population.
Zhang
Xue-Jun
XJ
Institute of Dermatology, Anhui Medical University, No. 69 Meishan Road, Hefei, Anhui 230032, PR China. ayzxj@mail.hf.ah.cn
Zhang
An-Ping
AP
Yang
Sen
S
Gao
Min
M
Wei
Sheng-Cai
SC
He
Ping-Ping
PP
Wang
Hong-Yan
HY
Song
Ying-Xue
YX
Cui
Yong
Y
Chen
Jian-Jun
JJ
D000328:Adult; D017668:Age of Onset; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D015395:Histocompatibility Antigens Class I