title: Genetic interaction between a maternal factor and the zygotic genome controls the intestine length in PRM/Alf mice.
abstract: Postoperative management of small and large bowel resections would be helped by use of intestinotrophic molecules. Here, we present a mouse inbred strain called PRM/Alf that is characterized by a selective intestinal lengthening. We show that PRM/Alf intestine is one-third longer compared with other inbred strains. The phenotype is acquired mostly during the postnatal period, before weaning. Its genetic determinism is polygenic, and involves a strong maternal effect. Cross-fostering experiments revealed that the dam's genotype acts synergistically with the offspring's genotype to confer the longest intestine. Moreover, genes in the offspring have a direct effect on intestine length. Possible involvement of milk growth factors and identification of candidate genes are discussed.
authors.affiliation: UMR 955 INRA-ENVA de Génétique Moléculaire et Cellulaire, Ecole Nationale Vétérinaire d'Alfort, 94704 Maisons-Alfort cedex, France.
authors.forename: Geneviève
authors.initials: G
authors.lastname: Aubin-Houzelstein
authors.forename: Nelly R
authors.initials: NR
authors.lastname: Da Silva
authors.forename: Sylvain
authors.initials: S
authors.lastname: Bellier
authors.forename: Pierrick
authors.initials: P
authors.lastname: Salaün
authors.forename: Xavier
authors.initials: X
authors.lastname: Montagutelli
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Panthier
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000378:metabolism*; D001835:Body Weight; D005111:Extrachromosomal Inheritance; D005260:Female; D016678:Genome; D005838:Genotype; D007422:Intestines / Q000033:anatomy & histology* / Q000254:growth & development; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008892:Milk / Q000737:chemistry; D009035:Mothers; D020412:Multifactorial Inheritance; D010641:Phenotype; D012727:Sex Characteristics; D015053:Zygote / Q000378:metabolism*
chemical_list: D001685:Biological Factors