Immunochemical determination of xenobiotics with endocrine disrupting effects.
This paper is a review with more than 100 references discussing the immunochemical methods reported in the literature for the most important man-made chemicals with suspected endocrine disrupting activity. Details regarding immunizing hapten design, antibody production, and the features (limit of detection, dynamic range, specificity) of the most important immunochemical methods developed (ELISA, FIIA, immunosorbents, immunosensors, etc.) are presented for important environmental pollutants such as bisphenol A, phthalates, alkylphenol polyethoxylates, alkylphenols, polychlorinated biphenyl compounds, and dioxins. Availability of commercial reagents and methods is reported.
Estévez-Alberola
M-C
MC
Department of Biological Organic Chemistry, IIQAB-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain.
Marco
M-P
MP
D000818:Animals; D002846:Chromatography, Affinity / Q000379:methods; D004702:Endocrine Glands / Q000187:drug effects*; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D015262:Xenobiotics / Q000032:analysis* / Q000633:toxicity
D015262:Xenobiotics