title: Comparison of three outpatient regimens in the management of nausea and vomiting in pregnancy.
abstract: OBJECTIVE
  This study compares pyridoxine-metoclopramide combination therapy to prochlorperazine and promethazine monotherapies in the outpatient treatment of nausea and vomiting in pregnancy.
  
  
  METHODS
  In total, 174 first trimester, singleton pregnancies were evaluated for nausea and vomiting. Patients were prospectively randomized into three treatment groups: pyridoxine-metoclopramide, prochlorperazine, or promethazine. Prior to, and on the third day, patients recorded their subjective responses to the given treatment and their number of emesis episodes. The three treatment groups were compared for therapy response.
  
  
  RESULTS
  There were no differences in the number of emesis episodes prior to treatment. Both subjective and objective responses to treatment differed among the three groups when comparing the combination therapy to the monotherapies (p<0.05).
  
  
  CONCLUSIONS
  Combination therapy with pyridoxine and metoclopramide appears to be superior to either monotherapy in the treatment of nausea and vomiting in pregnancy.
authors.affiliation: Tufts University School of Medicine, Boston, MA, USA.
authors.forename: Fadi A
authors.initials: FA
authors.lastname: Bsat
authors.forename: Despina E
authors.initials: DE
authors.lastname: Hoffman
authors.forename: David E
authors.initials: DE
authors.lastname: Seubert
mesh_terms: D000328:Adult; D000932:Antiemetics / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000188:drug therapy; D008787:Metoclopramide / Q000008:administration & dosage*; D009325:Nausea / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011346:Prochlorperazine / Q000008:administration & dosage*; D011398:Promethazine / Q000008:administration & dosage*; D011446:Prospective Studies; D011736:Pyridoxine / Q000008:administration & dosage*; D016896:Treatment Outcome; D014839:Vomiting / Q000188:drug therapy*
chemical_list: D000932:Antiemetics; D011398:Promethazine; D011736:Pyridoxine; D008787:Metoclopramide; D011346:Prochlorperazine