One-pot synthesis of an AZT boranophosphate conjugated with tyrosine: a potential prodrug candidate.
A one-pot synthesis of P-tyrosinyl(P-O)-5'-P-AZT boranophosphate 7 via a phosphoramidite method is described. The P-boranophosphate diastereomers were separated by RP-HPLC, and their structures were confirmed by NMR and MS.
Li
Ping
P
Department of Chemistry, Paul M. Gross Chemical Laboratory, Duke University, Durham, North Carolina 27708-0346, USA.
Shaw
Barbara Ramsay
BR
D019380:Anti-HIV Agents / Q000138:chemical synthesis; D001880:Boranes; D007202:Indicators and Reagents; D010710:Phosphates; D011355:Prodrugs / Q000138:chemical synthesis*; D014443:Tyrosine; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
D019380:Anti-HIV Agents; D001880:Boranes; D007202:Indicators and Reagents; D010710:Phosphates; D011355:Prodrugs; D014443:Tyrosine; D015215:Zidovudine