Onycholysis with the appearance of a "sunset" secondary to capecitabine.
Capecitabine is an antineoplastic agent that is currently the only effective treatment for patients with advanced or metastatic breast cancer in whom anthracycline or taxoid treatment has failed. Dermatologic side effects have included hand-foot syndrome and one case of onycholysis. We report a case of onycholysis with appearance of a "sunset" induced by capecitabine.
Maino
Kimberly L
KL
Division of Clinical Research, National Naval Medical Center, 8901 Wisconsin Ave, Bethesda, MD 20899, USA. drmaino@aol.com
Norwood
Christopher
C
Stashower
Mitchell E
ME
D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D000069287:Capecitabine; D003841:Deoxycytidine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D004890:Erythema / Q000139:chemically induced; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced*; D009260:Nail Diseases / Q000139:chemically induced*
D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil