Hormone-based therapies in MS.
It is well established in multiple sclerosis (MS) that the frequency of relapses decreases in late pregnancy, but increases in the post-partum period. This protective effect is probably due to hormonal and immune response changes induced by pregnancy. Oestrogens may be responsible, at least in part, for this protective effect. The potential use of oestrogens as therapy for MS is discussed.
Voskuhl
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UCLA Multiple Sclerosis Program, Department of Neurology, University of California-Los Angeles, 710 Westwood Plaza, A145, Los Angeles, CA 90095, USA. rvoskuhl@ucla.edu
D000284:Administration, Oral; D004967:Estrogens / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D004967:Estrogens