Reproducibility of plasma insulin kinetics during intraperitoneal insulin treatment by programmable pumps.
OBJECTIVE
To study the reproducibility of plasma insulin kinetics during intraperitoneal (IP) insulin therapy using an implanted programmable pump in patients with type 1, insulin dependent, diabetes mellitus (IDDM).


METHODS
In a group of ten type 1 IDDM patients beginning chronic IP insulin treatment with an implanted pump, plasma free insulin profiles were determined from 12: 00 am to 12: 30 pm on two separate test days, one month apart. Anti-insulin antibody (AIA) levels were measured on each test day.


RESULTS
From test day 1 to test day 2, no difference was observed in morning fasting free insulin levels (m +/- SD): 9.7 +/- 5.4 mU/L versus 9.8 +/- 5.3 mU/L, insulin peak values: 19.1 +/- 17 mU/L versus 20.8 +/- 9.9 mU/L, time to peak: 40 +/- 15 versus 42.8 +/- 16 minutes or post-bolus area under the plasma free insulin curve (AUC): 40.7 +/- 29 mU/L.h versus 45.5 +/- 29 mU/L.h. The intrapatient coefficient of variation was 14.4 +/- 13% for insulin peaks and 16.9 +/- 9.2% for post-bolus AUC. A significant increase in AIA levels (m +/- SD) was observed from 16.5 +/- 18% on test day 1 to 28.1 +/- 28% on test day 2.


CONCLUSIONS
The reproducibility of plasma free insulin profiles is highly satisfactory during insulin delivery by the IP route using an implanted device.
Schaepelynck Bélicar
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Service de Nutrition-Endocrinologie-Maladies Métaboliques, Hôpital Timone Adultes, Marseille, France. pauline.schaepelynck@mail.ap-hm.fr
Vague
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P
Lassmann-Vague
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V
D000328:Adult; D017668:Age of Onset; D019540:Area Under Curve; D015992:Body Mass Index; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D007330:Insulin Antibodies / Q000097:blood; D007332:Insulin Infusion Systems; D011863:Radioimmunoassay; D015203:Reproducibility of Results
D007328:Insulin; D007330:Insulin Antibodies