Contradictory functions of the sulfatide in the blood coagulation system.
It has long been controversial whether sulfatide stimulates blood coagulation or inhibits blood coagulation. In this paper, I demonstrated not only anticoagulant activity but also coagulant activity of sulfatide in vivo by using experimental animal models and presented the possibility that sulfatide may function contradictorily under physiological and/or pathological conditions. For instance, I presented possible involvement of sulfatide in thrombotic diseases associated with cancers.
Kyogashima
M
M
Seikagaku Corporation Tokyo Research Institute, 1253, Tateno 3-chome Higashiyamato-shi, Tokyo 207-0021, Japan. kyogashi@to.seikagaku.co.jp
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology*; D003029:Coagulants / Q000494:pharmacology; D005174:Factor XII / Q000037:antagonists & inhibitors; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D009369:Neoplasms / Q000097:blood / Q000150:complications; D051381:Rats; D013433:Sulfoglycosphingolipids / Q000097:blood* / Q000494:pharmacology; D013927:Thrombosis / Q000097:blood / Q000209:etiology
D000925:Anticoagulants; D003029:Coagulants; D013433:Sulfoglycosphingolipids; D005174:Factor XII