title: [Cerebral atrophy in multiple sclerosis patients treated periodically with boluses of methylprednisolone].
abstract: BACKGROUND
  In the last years advances in the treatment of the remittant and secondary progressive forms of the multiple sclerosis (MS) have taken place. In the primary progressive forms (PP) the side effects of potentially useful drugs prevent their use; in some studies an improvement of the evolution with the intravenous administration of periodic pulses of methylprednisolone (MP) has been observed.
  
  
  OBJECTIVE
  To evaluate if periodic pulses of intravenous MP injected every 4-6 weeks increase the degree of cerebral atrophy of the patients with PP MS.
  
  
  METHODS
  We studied 11 patients with PP MS treated during 33 months with periodic pulses of intravenous MP. The degree of cerebral atrophy was evaluated in axial cuts of 10 mm of studies of magnetic resonance with the indices of Evans, bicaudate, bifrontal, frontal spears and bithalamic. The statistical evaluation of the results was made applying the test of Wilcoxon-Mann-Whitney.
  
  
  RESULTS
  There are not statistically significant differences in the degree of cerebral atrophy with any of the used indices.
  
  
  CONCLUSIONS
  Periodic pulses of intravenous MP do not accelerate the cerebral atrophy in patients with progressive forms of multiple sclerosis.
authors.affiliation: Sección de Neurología, Hospital Povisa, Vigo, España. patopatonrl@mixmail.com
authors.forename: A
authors.initials: A
authors.lastname: Pato-Pato
authors.forename: J M
authors.initials: JM
authors.lastname: Prieto
authors.forename: M
authors.initials: M
authors.lastname: Lema
authors.forename: D
authors.initials: D
authors.lastname: Dapena-Bolaño
authors.forename: J
authors.initials: J
authors.lastname: Abella-Corral
authors.forename: J M
authors.initials: JM
authors.lastname: Pumar
mesh_terms: D000328:Adult; D001284:Atrophy; D002540:Cerebral Cortex / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D020528:Multiple Sclerosis, Chronic Progressive / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D008775:Methylprednisolone