title: Synthesis and biological evaluation of beta-D-pentofuranonucleoside derivatives of 2-azidoadenine and 6-azidopurines.
abstract: Beta-D-pentofuranonucleoside derivatives of 2-azidoadenine and 6-azidopurines have been synthesized. The azido-tetrazolo tautomerism observed on such nucleoside analogues has been studied. The compounds were tested for their activity against HIV and HBV but they did not show significant antiviral effect.
authors.affiliation: Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-Université Montpellier II, Montpellier, France. cmathe@univ-montp2.fr
authors.forename: Christophe
authors.initials: C
authors.lastname: Mathé
authors.forename: Thierry
authors.initials: T
authors.lastname: Lioux
authors.forename: Gilles
authors.initials: G
authors.lastname: Gosselin
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001386:Azides / Q000138:chemical synthesis; D006678:HIV / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D011687:Purines / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D019380:Anti-HIV Agents; D000998:Antiviral Agents; D001386:Azides; D007202:Indicators and Reagents; D011687:Purines; D000225:Adenine