title: [Papules on the dorsal interphalangeal joints and an unspecific immunostimulating agent].
abstract: We report the case of an 8-year-old girl with skin eruptions on both hands that were thought to be of viral origin and, therefore, had been treated with an unspecific immunostimulating agent, containing large amounts of inosine. Under this therapy, which is - despite contrasting knowledge - still thought to be harmless and without serious side effects in the opinion of many physicians and especially medical laymen, the girl's condition worsened rapidly. Diagnosis of juvenile dermatomyositis was made. Because inosine is able to enhance T-cell proliferation and reverse immunosuppression in vitro, both mechanisms may have aggravated the disease course in our patient, once the autoimmune process of dermatomyositis has been initiated.
authors.affiliation: Reinstorfweg 10a, 21107 Hamburg. GMLackmann@t-online.de
authors.forename: G M
authors.initials: GM
authors.lastname: Lackmann
authors.forename: J
authors.initials: J
authors.lastname: Ndagijimana
authors.forename: T
authors.initials: T
authors.lastname: Niehues
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D015551:Autoimmunity; D002648:Child; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003882:Dermatomyositis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D005260:Female; D006229:Hand Dermatoses / Q000188:drug therapy*; D006801:Humans; D007288:Inosine / Q000008:administration & dosage / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents; D007288:Inosine; D011239:Prednisolone