title: Oxidative stress is associated with adiposity and insulin resistance in men.
abstract: To investigate the direct relationship of oxidative stress with obesity and insulin resistance in men, we measured the plasma levels of 8-epi-prostaglandin F2alpha (PGF2alpha) in 14 obese and 17 nonobese men and evaluated their relationship with body mass index; body fat weight; visceral, sc, and total fat areas, measured by computed tomography; and glucose infusion rate during a euglycemic hyperinsulinemic clamp study. Obese men had significantly higher plasma concentrations of 8-epi-PGF2alpha than nonobese men (P < 0.05). The plasma levels of 8-epi-PGF2alpha were significantly correlated with body mass index (r = 0.408; P < 0.05), body fat weight (r = 0.467; P < 0.05), visceral (r = 0.387; P < 0.05) and total fat area (r = 0.359; P < 0.05) in all (obese and nonobese) men. There was also a significant correlation between the plasma levels of 8-epi-PGF2alpha and glucose infusion rate in obese men (r = -0.552; P < 0.05) and all men (r = -0.668; P < 0.01). In all subjects, the plasma levels of 8-epi-PGF2alpha were significantly correlated with fasting serum levels of insulin (r = 0.487; P < 0.01). In brief, these findings showed that the circulating levels of 8-epi-PGF2alpha are related to adiposity and insulin resistance in men. Although correlation does not prove causation, the results of this study suggest that obesity is an important factor for enhanced oxidative stress and that this oxidative stress triggers the development of insulin resistance in men.
authors.affiliation: Third Department of Internal Medicine, Mie University School of Medicine, Mie, 514-8507 Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Urakawa
authors.forename: Akira
authors.initials: A
authors.lastname: Katsuki
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Sumida
authors.forename: Esteban C
authors.initials: EC
authors.lastname: Gabazza
authors.forename: Shuichi
authors.initials: S
authors.lastname: Murashima
authors.forename: Kohei
authors.initials: K
authors.lastname: Morioka
authors.forename: Noriko
authors.initials: N
authors.lastname: Maruyama
authors.forename: Nagako
authors.initials: N
authors.lastname: Kitagawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Tanaka
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Hori
authors.forename: Kaname
authors.initials: K
authors.lastname: Nakatani
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yano
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Adachi
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D002784:Cholesterol / Q000097:blood; D015237:Dinoprost / Q000031:analogs & derivatives*; D028441:F2-Isoprostanes / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000097:blood*; D018384:Oxidative Stress
chemical_list: D028441:F2-Isoprostanes; C075750:8-epi-prostaglandin F2alpha; D002784:Cholesterol; D015237:Dinoprost