Enantioselective Michael reaction of malonates to nitroolefins catalyzed by bifunctional organocatalysts.
Michael reaction of malonates to nitroolefins with chiral bifunctional organocatalysts, bearing both a thiourea and tertiary amino group, afforded Michael adducts with high yields and enantioselectivities (up to 95%, up to 93% ee).
Okino
Tomotaka
T
Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
Hoashi
Yasutaka
Y
Takemoto
Yoshiji
Y