Synthetic studies towards a novel, chemical stable, abasic site analogue of DNA.
We synthesized the phosphinate 7 via photoaddition of methanol to the alpha, beta unsaturated deoxyribono lactone as the key step, followed by an Arbusov reaction for the introduction of phosphorous. Precursor 7 serves for the synthesis and incorporation into DNA of a novel chemically stable abasic site analogue that might act as an inhibitor for DNA glycosylases.
Hirtz
Caroline
C
Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.
Leumann
Christian J
CJ
D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D004260:DNA Repair; D003855:Deoxyribose; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis; D010720:Phosphines
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D010720:Phosphines; D003855:Deoxyribose; D004247:DNA