title: Sjögren's disease.
abstract: In summary, Sjögren's syndrome is a chronic autoimmune disorder characterized by lymphocytic infiltration of the exocrine glands, particularly the salivary and lacrimal glands. The sicca complex of xerophthalmia and xerostomia are the hallmark features of Sjögren's symptomatology. In addition to these hallmark symptoms of oral and ocular dryness, one third of patients with Sjögren's syndrome present with extraglandular manifestations. Many osf these extraglandular manifestations, as well as the sicca symptoms, have otolaryngologic relevance. Because patients with Sjögren's syndrome may present with vague or nonspecific head and neck complaints, ranging from oral dryness to hoarseness to hearing loss, an otolaryngologist's high index of suspicion for this disorder may prevent delay in diagnosis, allow appropriate diagnostic evaluation, and optimize therapeutic intervention.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Boston University School of Medicine, 88 East Newton Street, Boston, MA 02118, USA.
authors.forename: Elizabeth J
authors.initials: EJ
authors.lastname: Mahoney
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Spiegel
mesh_terms: D004066:Digestive System Diseases / Q000209:etiology; D006801:Humans; D007818:Laryngeal Diseases / Q000209:etiology; D008232:Lymphoproliferative Disorders / Q000209:etiology; D010038:Otorhinolaryngologic Diseases / Q000209:etiology*; D012859:Sjogren's Syndrome / Q000150:complications* / Q000175:diagnosis / Q000628:therapy