[Epstein-Barr virus associated central nervous system leiomyosarcoma occurring after renal transplantation: case report and review of the literature].
Central nervous system leiomyosarcomas are extremely rare, however, they became more frequent among immunodeficient patients, either in a patients infected with human immunodeficiency virus (HIV), or after organ transplantation. The data of the literature indicate that the infection by Epstein-Barr virus (EBV) plays a causal role in the development of these tumours but its precise role in the oncogenesis remains unresolved. We report a new case of EBV associated leiomyosarcoma of the left cavernous sinus occurring after renal transplantation. The epidemiological, clinical, pathological and therapeutic characteristics of these tumours are discussed.
Tahri
A
A
Centre des tumeurs, groupe hospitalier Pitié-Salpêtrière, AP-HP, 47-83, boulevard de l'Hôpital, 75651 Paris, cedex 13, France.
Noel
G
G
Figuerella-Branger
D
D
Goncalves
A
A
Feuvret
L
L
Jauffret
E
E
Brun
B
B
Mazeron
J J
JJ
Baillet
F
F
D000328:Adult; D001932:Brain Neoplasms / Q000209:etiology / Q000821:virology*; D002426:Cavernous Sinus / Q000473:pathology; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification / Q000472:pathogenicity*; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects; D007890:Leiomyosarcoma / Q000209:etiology / Q000821:virology*; D008297:Male; D012307:Risk Factors