title: Imiquimod is highly effective for extensive, hyperproliferative condyloma in children.
abstract: We describe a dramatic response to imiquimod of long-lasting, highly proliferative extensive perianal condylomas involving the anal canal in a 19-month-old girl. Her mother was free of condyloma and allegedly had no human papillomavirus (HPV) infection during pregnancy. There was no evidence of sexual abuse. Application of 5% imiquimod cream to the child every other day for 3 weeks resulted in almost complete resolution of the warts, with total clearance within another 2 weeks. The inflammatory reaction was moderate. Since there is still discussion of whether imiquimod may be prescribed for small children, this case of very extensive condyloma provides evidence that the compound is safe and highly effective.
authors.affiliation: Department of Dermatology and Venereology, Warsaw School of Medicine, Warsaw, Poland.
authors.forename: Slawomir
authors.initials: S
authors.lastname: Majewski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Pniewski
authors.forename: Magdalena
authors.initials: M
authors.lastname: Malejczyk
authors.forename: Stefania
authors.initials: S
authors.lastname: Jablonska
mesh_terms: D000287:Administration, Topical; D000634:Aminoquinolines / Q000008:administration & dosage / Q000627:therapeutic use*; D003218:Condylomata Acuminata / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077271:Imiquimod; D007223:Infant
chemical_list: D000634:Aminoquinolines; D000077271:Imiquimod