[The impact of plant-sterol supplemented diet on the LDL and oxidized-LDL levels in young men].
As evidenced by clinical trials, sterols and stanols may reduce LDL-cholesterol more potently than the restriction in the dietary intake of saturated fatty acids and cholesterol. So far, in Poland no clinical trials on the preventive applications of plant sterol margarines were conducted. Therefore, the objective of our study was to confirm their utility in primary prevention of cardiovascular disorders in young, healthy men who habitually consume butter. The present study was conducted on 42 healthy men (24.5 +/- 6 yr)--priests students living throughout the study in a boarding house and 4 weeks consumed during the study the same amounts (portions) of all diet elements, and the only difference were the two compared fats used in the study. 31 men consumed daily 15 g of extra butter (30 g/d), and 31 men consumed twice daily 15 g of margarine (30 g/d) with the addition of plant sterol esters amounting to 8 g/100 g of the product. Total cholesterol reduction by 7% (p < 0.001), and above all the LDL reduction by as much as over 11% (p < 0.001) confirm the beneficial effect of sterols on lipid parameters. The first time we observed reduction of oxidized LDL (oxy-LDL) by as much as 21% (p < 0.001) after consumption of margarine with plant sterol. This results suggest that sterols have pleiotropic effects, similar to statins. Our proposal of this results is that sterol have anti-inflammatory effect, probability by reduction of oxysterols from food. Of note is the fact that dietary sterol intake did not cause any changes in the HDL fraction level. Also the observed reduction in the atherogenic index (LDL-C/HDL-C) by over 11% (p < 0.001). On the other hand, the disadvantageous effect of butter-containing diet on blood serum lipids, with a trend towards their increase, was confirmed in the present study. The results obtained indicate a potent hypolipaemic activity of dietary sterol intake in normocholesterolemics young men, and probably that is the one of the important methods of prevention heart disease.
Kozłowska-Wojciechowska
Małgorzata
M
Zakład Upowszechniania Wiedzy o Zywności i Zywieniu Instytutu Zywności i Zywienia w Warszawie.
Milo
Barbara
B
Makarewicz-Wujec
Magdalena
M
Chełstowski
Kornel
K
Naruszewicz
Marek
M
D000328:Adult; D015992:Body Mass Index; D019587:Dietary Supplements; D004797:Enzyme-Linked Immunosorbent Assay; D005227:Fatty Acids / Q000008:administration & dosage*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008383:Margarine; D018514:Plant Structures
D005227:Fatty Acids; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D008383:Margarine