Clinical outcome of fetuses with sonographic diagnosis of isolated micrognathia.
OBJECTIVE
To describe the clinical outcome of fetuses with the prenatal sonographic diagnosis of isolated micrognathia.


METHODS
A retrospective review of fetuses and infants with the prenatal diagnosis of isolated micrognathia for April 1990 to August 2001 was undertaken. Isolated micrognathia was considered if no other anatomic, growth, or amniotic fluid abnormalities were detected by a detailed ultrasound examination. Sources of outcome data included maternal and neonatal medical records, prenatal genetics records, and karyotype results.


RESULTS
Fifty-eight fetuses with the diagnosis of micrognathia were identified. Fifteen fetuses (26%) had isolated micrognathia by prenatal sonogram. After neonatal examination, 14 of 15 were found to have at least one additional abnormality. Eleven had a cleft of the soft and/or hard palate. Seven (54%) of 13 live-born neonates had mild to severe airway obstruction that required intervention. Four (31%) of 13 experienced feeding difficulties of varying duration. Follow-up data were available for 1 to 10 years. Eight (62%) of 13 children are reported to be doing well. Five (38%) of 13 children are reported to have mild to severe developmental delay.


CONCLUSIONS
If micrognathia is the only sonographic finding identified, physicians and families should be prepared for possible respiratory difficulty at delivery, the presence of a cleft palate, and/or developmental delay.
Vettraino
Ivana M
IM
Department of Obstetrics and Gynecology, William Beaumont Hospital, Royal Oak, Michigan 48073, USA. ivettraino@beaumonthospitals.com
Lee
Wesley
W
Bronsteen
Richard A
RA
Harper
Cheryl E
CE
Aughton
David
D
Comstock
Christine H
CH
D000328:Adult; D002971:Cleft Lip / Q000000981:diagnostic imaging / Q000453:epidemiology; D002972:Cleft Palate / Q000000981:diagnostic imaging / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008499:Medical Records; D008824:Michigan / Q000453:epidemiology; D008844:Micrognathism / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012127:Respiratory Distress Syndrome, Newborn; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal