title: Previous cytomegalovirus infection and restenosis after aggressive angioplasty with provisional stenting.
abstract: The aim of this study was to determine the impact of previous with cytomegalovirus (CMV) on restenosis after aggressive angioplasty with provisional stenting.
  
  
  METHODS
  We prospectively studied 78 consecutive patients scheduled for 6-month follow-up coronary angiography as part of the SIPS study. Anti-CMV IgG and IgM antibodies were measured on admission.
  
  
  RESULTS
  Anti-CMV IgG positive and anti-CMV IgG negative patients had similar minimal lumen diameter (MLD) in the target vessel before (0.68 +/- 0.49 mm vs 0.71 +/- 0.52 mm, P = 0.84) and directly after the intervention (2.50 +/- 0.60 mm vs 2.57 +/- 0.52 mm, P = 0.58). After 6 months, however, the MLD was significantly smaller in CMV-positive as compared to CMV-negative patients (1.57 +/- 0.82 mm vs 2.00 +/- 0.83 mm, P < 0.03). Net lumen gain at 6 months was significantly lower in CMV-positive patients (0.89 +/- 0.79 mm vs 1.30 +/- 0.87 mm, P < 0.04) and the rate of clinically relevant restenosis was significantly higher (31% vs 7%, P < 0.02). In a multivariate logistic regression model, CMV seropositivity was an independent predictor of restenosis (odds ratio 5.7 (95% CI 1.2-30.3, P = 0.04).
  
  
  CONCLUSIONS
  Six months after aggressive coronary angioplasty with provisional stenting, patients with prior CMV infection had a smaller MLD and a higher restenosis rate. CMV seropositivity was a strong independent predictor of restenosis.
authors.affiliation: Herz-Zentrum Bad Krozingen, Germany. chmueller@uhbs.ch
authors.forename: Christian
authors.initials: C
authors.lastname: Mueller
authors.forename: John McB
authors.initials: JM
authors.lastname: Hodgson
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Bestehorn
authors.forename: Martin
authors.initials: M
authors.lastname: Brutsche
authors.forename: Andrè P
authors.initials: AP
authors.lastname: Perruchoud
authors.forename: Stephan
authors.initials: S
authors.lastname: Marsch
authors.forename: Helmut
authors.initials: H
authors.lastname: Roskamm
authors.forename: Heinz J
authors.initials: HJ
authors.lastname: Buettner
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D023903:Coronary Restenosis / Q000209:etiology*; D023921:Coronary Stenosis / Q000628:therapy*; D003586:Cytomegalovirus Infections / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015607:Stents