title: Randomized, double-blind study of pramipexole with placebo and bromocriptine in advanced Parkinson's disease.
abstract: We compared the efficacy and safety of pramipexole (PPX) with placebo in the treatment of advanced Parkinson's disease (PD) as an adjunct to levodopa. A bromocriptine (BR) group was included to enable determination of the noninferiority of PPX relative to BR as the standard treatment.
authors.affiliation: Department of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan. y_Mizuno@med.juntendo.ac.jp
authors.forename: Yoshikuni
authors.initials: Y
authors.lastname: Mizuno
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yanagisawa
authors.forename: Sadako
authors.initials: S
authors.lastname: Kuno
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Kazuko
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Origasa
authors.forename: Hisayuki
authors.initials: H
authors.lastname: Kowa
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D052160:Benzothiazoles; D001971:Bromocriptine / Q000627:therapeutic use*; D003710:Demography; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*; D000077487:Pramipexole; D011446:Prospective Studies; D011788:Quality of Life; D013844:Thiazoles / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000978:Antiparkinson Agents; D052160:Benzothiazoles; D013844:Thiazoles; D001971:Bromocriptine; D000077487:Pramipexole