title: Synthesis of 2'-spiro ribo- and arabinonucleosides.
abstract: Four conformationally restricted bicyclic 2'-spiro nucleosides were synthesised and incorporated into oligonucleotides. These spiro nucleotides induced decreased duplex thermostabilities.
authors.affiliation: Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark.
authors.forename: B Ravindra
authors.initials: BR
authors.lastname: Babu
authors.forename: Lise
authors.initials: L
authors.lastname: Keinicke
authors.forename: Jesper
authors.initials: J
authors.lastname: Wengel
mesh_terms: D001087:Arabinonucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D008968:Molecular Conformation; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D012313:RNA / Q000737:chemistry; D013141:Spiro Compounds; D013816:Thermodynamics
chemical_list: D001087:Arabinonucleosides; D009838:Oligodeoxyribonucleotides; D013141:Spiro Compounds; D012313:RNA; D004247:DNA