Alternative splicing in the nervous system: an emerging source of diversity and regulation.
Alternative splicing is emerging as a major mechanism of functional regulation in the human genome. Previously considered to be an unusual event, it has been detected by many genomics studies in 40%-60% of human genes. Moreover, it appears to be of central importance for neuronal genes and other genes involved in "information processing" functions. In this review, we will summarize alternative splicing's effects on mRNA transcripts, protein products, biological function, and human disease, focusing on genes of neuropsychiatric interest. We will also describe the latest experimental methods and database resources that can help neuroscientists make use of alternative splicing in their own research.
Lee
Christopher J
CJ
Molecular Biology Institute, UCLA Center for Bioinformatics, Center for Genomics and Proteomics, Department of Chemistry and Biochemistry, Boyer Hall, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Irizarry
Kris
K
D017398:Alternative Splicing / Q000235:genetics*; D002490:Central Nervous System / Q000502:physiology*; D019992:Databases as Topic; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D023281:Genomics / Q000379:methods; D006801:Humans; D009474:Neurons / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics; D018079:Receptors, GABA / Q000235:genetics; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics; D015398:Signal Transduction / Q000235:genetics
D012333:RNA, Messenger; D018079:Receptors, GABA; D016194:Receptors, N-Methyl-D-Aspartate