5'-O-fluorosulfonylbenzoyl esters of purine nucleosides as potential inhibitors of NTPase/helicase and polymerase of Flaviviridae viruses.
Synthesis and interactions of guanosine, inosine and ribavirin 5'-fluorosulfonylbenzoyl esters with hepatitis C virus (HCV) and Flaviviruses NTPase/helicase and polymerase are described.
Bretner
M
M
Laboratory of Antimetabolites, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland. mbretner@hotmail.com
Schalinski
S
S
Borowski
P
P
Kulikowski
T
T
D004265:DNA Helicases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018067:Flaviviridae / Q000201:enzymology*; D043583:Nucleoside-Triphosphatase / Q000037:antagonists & inhibitors*; D011684:Purine Nucleosides / Q000494:pharmacology*; D011687:Purines / Q000494:pharmacology
D004791:Enzyme Inhibitors; D011684:Purine Nucleosides; D011687:Purines; D043583:Nucleoside-Triphosphatase; D004265:DNA Helicases