title: Early head cooling in newborn piglets is neuroprotective even in the absence of profound systemic hypothermia.
abstract: BACKGROUND
  Selective head cooling in the newborn infant has been proposed as a neuroprotective treatment with a lower level of systemic adverse effect than that of systemic hypothermia. However, the efficacy is not confirmed as well as that of systemic hypothermia. In order to analyze the safety and efficacy of selective head cooling, 25 newborn piglets were randomly selected for either normothermic or hypothermic treatment.
  
  
  METHODS
  Global hypoxic insult was induced by lowering the oxygen concentration to the maximal level to maintain the background electroencephalogram (EEG) voltage under 7 microV for 45 min. The core temperature of normothermic piglets was maintained between 38.5 degrees C and 39 degrees C, while prophylactic cooling was applied to the hypothermic piglets at the same time of the insult. Very mild systemic hypothermia by 1 degrees C was induced in addition to selective head cooling with 10 degrees C coolant temperature. Animals were killed for histopathological examination seven hours after the end of the insult.
  
  
  RESULTS
  Two normothermic piglets died while all hypothermic piglets survived. Neuropathological findings were significantly severer in the normothermic group than in the hypothermic group. Intracranial pressure was significantly lower, and EEG recovery was significantly better in the hypothermic piglets. There was no significant difference in the lowest oxygen concentration, degrees of acidosis, blood lactate, and blood pressure between the groups, although heart rate was significantly lower in the hypothermic group.
  
  
  CONCLUSIONS
  We have demonstrated that early head cooling was effective in preventing some of the earliest brain damage due to hypoxic insult even in the absence of profound systemic hypothermia.
authors.affiliation: Division of Neonatology, Perinatal Center, Nagano Children's Hospital, Toyoshina, Nagano, Japan. o.iwata@orbix.uk.net
authors.forename: Osuke
authors.initials: O
authors.lastname: Iwata
authors.forename: Sachiko
authors.initials: S
authors.lastname: Iwata
authors.forename: Masanori
authors.initials: M
authors.lastname: Tamura
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Nakamura
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Sugiura
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Ogiso
authors.forename: Sachio
authors.initials: S
authors.lastname: Takashima
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001794:Blood Pressure; D005260:Female; D006168:Guinea Pigs; D006339:Heart Rate; D007036:Hypothermia, Induced; D002534:Hypoxia, Brain / Q000517:prevention & control*; D008297:Male