[Blood-activating and anti-inflammatory actions of Polygala fallax].
OBJECTIVE
To observe the blood-activating and anti-inflammatory actions of Polygala fallax Hesml. (PFH) in this paper.


METHODS
A series of experiments were performed to show the blood-activating and anti-inflammatory actions of PFH, including acute blood-stagnation model in rats induced by dextran of high molecular mass, observation on microcirculation in mice, platelet aggregation in vitro in rabbits, acute inflammation in mice induced by xylene or histamine, and PC-DTH.


RESULTS
PFH could remarkably decrease the whole blood relative viscosity. PFH could significantly dilate the micro-artery and micro-vein, increase the opening number of capillary in mice. However, PFH had no obvious effect on platelet aggregation induced by ADP in rabbits. PFH could significantly inhibit the increase of capillary permeability induced by histamine in mice, and decrease the mice ear-swelling induced by xylene. PFH could remarkably inhibit the induction-phase and attack-phase of PC-DTH in mice.


CONCLUSIONS
The results suggested that PFH could improve the hemorrheologic character in blood-stagnation state, invigorate the micro-circulation, and inhibit inflammation process.
Kou
Junping
J
Department of Complex Prescription of Chinese Materia Medica, China Pharmaceutical University, Nanjing 210038.
Ma
Renqiang
R
Zhu
Danni
D
Yan
Yongqing
Y
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D001809:Blood Viscosity / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004487:Edema / Q000473:pathology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D051379:Mice; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D010974:Platelet Aggregation / Q000187:drug effects; D031801:Polygala / Q000737:chemistry; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004365:Drugs, Chinese Herbal