Myelin oligodendrocyte glycoprotein is expressed in the peripheral nervous system of rodents and primates.
The myelin oligodendrocyte glycoprotein (MOG) is a minor CNS myelin-specific protein that is an important candidate autoantigen in multiple sclerosis. We now report that MOG mRNA transcripts are present in the peripheral nervous system of rodents and primates at levels approximately ten-fold lower than in brain as demonstrated by real time PCR. A major source of this signal are Schwann cells which are also shown to express MOG protein within their cytoplasm in vitro by immunohistochemistry. Expression of MOG by Schwann cells associated with tissue innervation may account for the widespread distribution of low levels of MOG mRNA transcripts, and potentially may provide a source of antigen that can influence the composition and function of the MOG-specific immune repertoire.
Pagany
Maria
M
Department of Neuroimmunology, Max-Planck Institute for Neurobiology, Am Klopferspitz 18a, 82152 Martinsried, Germany. pagany@neuro.mpg.de
Jagodic
Maja
M
Schubart
Anna
A
Pham-Dinh
Danielle
D
Bachelin
Corinne
C
Baron van Evercooren
Anne
A
Lachapelle
François
F
Olsson
Tomas
T
Linington
Christopher
C
D000818:Animals; D001921:Brain / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D007150:Immunohistochemistry; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000096:biosynthesis* / Q000235:genetics; D063308:Myelin-Oligodendrocyte Glycoprotein; D014066:Palatine Tonsil / Q000378:metabolism; D017933:Peripheral Nervous System / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012583:Schwann Cells / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism
C571326:MOG protein, human; C571328:Mog protein, rat; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D012333:RNA, Messenger