title: Synthesis and antiviral activity assay of novel (E)-3',5'-diamino-5-(2-bromovinyl)-2',3',5'-trideoxyuridine.
abstract: (E)-3',5'-diamino-5-(2-bromovinyl)-2',3',5'-trideoxyuridine (5), the diamino analogue of BVDU (1), was synthesized from BVDU. In contrast with BVDU, compound 5 did not show activity against herpes simplex virus or varicella-zoster virus.
authors.affiliation: Departamento de Química Orgánica e Inorgánica, Facultad de Química, Universidad de Oviedo, Oviedo, Spain.
authors.forename: Iván
authors.initials: I
authors.lastname: Lavandera
authors.forename: Susana
authors.initials: S
authors.lastname: Fernández
authors.forename: Miguel
authors.initials: M
authors.lastname: Ferrero
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Vicente
authors.initials: V
authors.lastname: Gotor
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives* / Q000737:chemistry; D015195:Drug Design; D007202:Indicators and Reagents; D015394:Molecular Structure; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014753:Vinyl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D007202:Indicators and Reagents; D014753:Vinyl Compounds; C052700:3',5'-di-O-acetyl-5-(2-bromovinyl)-2'-deoxyuridine; D001973:Bromodeoxyuridine; D014529:Uridine