title: Triplex formation involving 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) with 1-isoquinolone base analogue: efficient and selective recognition of C:G interruption.
abstract: For the effective recognition of C x G interruption in homopurine-homopyrimidine duplex DNA, we examined triplex-forming ability and sequence-selectivity of a triplex-forming oligonucleotide (TFO) involving of 2'-O, 4'-C-methylene bridged nucleic acid with 1-isoquinolone base analogue. We found that the modified TFO formed stable triplex with high binding affinity and sequence-selectivity.
authors.affiliation: Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Shinjuku-ku, Tokyo, Japan. htorigoe@ch.kagu.tus.ac.jp
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Torigoe
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hari
authors.forename: Satoshi
authors.initials: S
authors.lastname: Obika
authors.forename: Takeshi
authors.initials: T
authors.lastname: Imanishi
mesh_terms: D020029:Base Pairing; D003596:Cytosine; D004247:DNA / Q000737:chemistry*; D006147:Guanine; D006838:Hydrocarbons; D006860:Hydrogen Bonding; D007546:Isoquinolines; D008697:Methane / Q000031:analogs & derivatives*; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*
chemical_list: D006838:Hydrocarbons; D007546:Isoquinolines; D009838:Oligodeoxyribonucleotides; C030011:carbene; D006147:Guanine; D003596:Cytosine; D004247:DNA; C039109:isoquinoline; D008697:Methane