title: Neuronal ceroid-lipofuscinosis in a Labrador Retriever.
abstract: An 8-year-old Labrador Retriever with an 11-month history of progressive partial seizures and necropsy examination findings characteristic of the lamellar form of canine neuronal ceroid-lipofuscinosis (NCL) is presented. The clinical, light microscopic, and ultrastructural features of this case most closely resemble human adult-onset NCL (Kufs disease). This is the first report of NCL occurring in the Labrador Retriever breed.
authors.affiliation: Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
authors.forename: John H
authors.initials: JH
authors.lastname: Rossmeisl
authors.forename: Robert
authors.initials: R
authors.lastname: Duncan
authors.forename: Jonathan
authors.initials: J
authors.lastname: Fox
authors.forename: Erin S
authors.initials: ES
authors.lastname: Herring
authors.forename: Karen D
authors.initials: KD
authors.lastname: Inzana
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D008297:Male; D009046:Motor Neurons / Q000473:pathology / Q000648:ultrastructure; D009472:Neuronal Ceroid-Lipofuscinoses / Q000473:pathology / Q000662:veterinary*; D010487:Periaqueductal Gray / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology