title: Positional cloning of a novel gene influencing asthma from chromosome 2q14.
abstract: Asthma is a common disease in children and young adults. Four separate reports have linked asthma and related phenotypes to an ill-defined interval between 2q14 and 2q32 (refs. 1-4), and two mouse genome screens have linked bronchial hyper-responsiveness to the region homologous to 2q14 (refs. 5,6). We found and replicated association between asthma and the D2S308 microsatellite, 800 kb distal to the IL1 cluster on 2q14. We sequenced the surrounding region and constructed a comprehensive, high-density, single-nucleotide polymorphism (SNP) linkage disequilibrium (LD) map. SNP association was limited to the initial exons of a solitary gene of 3.6 kb (DPP10), which extends over 1 Mb of genomic DNA. DPP10 encodes a homolog of dipeptidyl peptidases (DPPs) that cleave terminal dipeptides from cytokines and chemokines, and it presents a potential new target for asthma therapy.
authors.affiliation: Oxagen, Milton Park, Oxfordshire, UK.
authors.forename: Maxine
authors.initials: M
authors.lastname: Allen
authors.forename: Andrea
authors.initials: A
authors.lastname: Heinzmann
authors.forename: Emiko
authors.initials: E
authors.lastname: Noguchi
authors.forename: Gonçalo
authors.initials: G
authors.lastname: Abecasis
authors.forename: John
authors.initials: J
authors.lastname: Broxholme
authors.forename: Chris P
authors.initials: CP
authors.lastname: Ponting
authors.forename: Sumit
authors.initials: S
authors.lastname: Bhattacharyya
authors.forename: Jon
authors.initials: J
authors.lastname: Tinsley
authors.forename: Youming
authors.initials: Y
authors.lastname: Zhang
authors.forename: Richard
authors.initials: R
authors.lastname: Holt
authors.forename: E Yvonne
authors.initials: EY
authors.lastname: Jones
authors.forename: Nick
authors.initials: N
authors.lastname: Lench
authors.forename: Alisoun
authors.initials: A
authors.lastname: Carey
authors.forename: Helene
authors.initials: H
authors.lastname: Jones
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Dickens
authors.forename: Claire
authors.initials: C
authors.lastname: Dimon
authors.forename: Rosie
authors.initials: R
authors.lastname: Nicholls
authors.forename: Crystal
authors.initials: C
authors.lastname: Baker
authors.forename: Luzheng
authors.initials: L
authors.lastname: Xue
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Townsend
authors.forename: Michael
authors.initials: M
authors.lastname: Kabesch
authors.forename: Stephan K
authors.initials: SK
authors.lastname: Weiland
authors.forename: David
authors.initials: D
authors.lastname: Carr
authors.forename: Erika
authors.initials: E
authors.lastname: von Mutius
authors.forename: Ian M
authors.initials: IM
authors.lastname: Adcock
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Barnes
authors.forename: G Mark
authors.initials: GM
authors.lastname: Lathrop
authors.forename: Mark
authors.initials: M
authors.lastname: Edwards
authors.forename: Miriam F
authors.initials: MF
authors.lastname: Moffatt
authors.forename: William O C M
authors.initials: WO
authors.lastname: Cookson
mesh_terms: D000595:Amino Acid Sequence; D001249:Asthma / Q000235:genetics*; D002889:Chromosomes, Human, Pair 2; D003001:Cloning, Molecular; D005838:Genotype; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics; D017386:Sequence Homology, Amino Acid