The steroid-responsive hiccup reflex arc: competitive binding to the corticosteroid-receptor?
Hiccups occurring secondary to high-doses of corticosteroids are a well-recognized problem in the field of neurosurgery. Numerous reports of oral, intravenous and intraarticular corticosteroids inducing hiccups exist in the literature. To date, there is only one case of anabolic steroids inducing hiccups. We now present a case of a patient who underwent a suboccipital craniotomy for resection of a cerebellar pontine angle meningioma. Postoperatively the patient was on high doses of Decadron and Oxandrin, an anabolic-anticatabolic agent used to combat the deleterious effects of corticosteroids. The patient suffered intractable hiccups postoperative day one, resistant to Thorazine. Oxandrin was discontinued to assess the possibility of a anabolic steroid-induced singultus. The hiccups resolved within 24 hours. This report validates the previous report on anabolic steroids inducing hiccups and exemplifies the ability for steroids as a class, due to there backbone structural homology, to induce function even as competitive inhibitors.
Dickerman
Rob D
RD
Department of Neurosurgery, North Shore University Hospital, New Hyde Park, NY, USA. drrdd@yahoo.com
Overby
Chris
C
Eisenberg
Mark
M
Hollis
Peter
P
Levine
Mitchell
M
D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D045930:Anabolic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001667:Binding, Competitive / Q000187:drug effects; D002528:Cerebellar Neoplasms / Q000601:surgery; D002530:Cerebellopontine Angle / Q000473:pathology; D004487:Edema / Q000150:complications / Q000188:drug therapy; D006606:Hiccup / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008579:Meningioma / Q000601:surgery; D010074:Oxandrolone / Q000009:adverse effects* / Q000627:therapeutic use; D011183:Postoperative Complications / Q000188:drug therapy; D011987:Receptors, Steroid / Q000187:drug effects*; D013256:Steroids / Q000009:adverse effects* / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D045930:Anabolic Agents; D011987:Receptors, Steroid; D013256:Steroids; D010074:Oxandrolone