title: Synthesis and biological evaluation of pyrimidine nucleosides fused with 3',4'-tetrahydrofuran ring.
abstract: Pyrimidine nucleosides fused with 3',4'-tetrahydrofuran ring were synthesized, starting from 1,2;5,6-di-O-isopropylidene-D-glucose and assayed for antiviral activities. Thymine analogue 1 and its corresponding 2'-deoxy analogue 3 exhibited high cytotoxicity instead of giving antiviral activities.
authors.affiliation: College of Pharmacy, Seoul National University, Seoul, Korea. mwchun@snu.ac.kr
authors.forename: Moon Woo
authors.initials: MW
authors.lastname: Chun
authors.forename: Myong Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Hea Ok
authors.initials: HO
authors.lastname: Kim
authors.forename: Hyung Ryong
authors.initials: HR
authors.lastname: Moon
authors.forename: Hee-Doo
authors.initials: HD
authors.lastname: Kim
authors.forename: Joong Hyup
authors.initials: JH
authors.lastname: Kim
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
mesh_terms: D005663:Furans; D007202:Indicators and Reagents; D008958:Models, Molecular; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005663:Furans; D007202:Indicators and Reagents; D011741:Pyrimidine Nucleosides; C018674:tetrahydrofuran