title: Ascorbic acid is a requirement for the morphogenesis of the human filarial parasite Brugia malayi.
abstract: The nematode parasites Wuchereria bancrofti, Brugia malayi, and B. timori cause a disease in humans known as lymphatic filariasis, which afflicts approximately 120 million people worldwide. The parasites enter the human host from the mosquito either as L3 or as infective larvae and subsequently differentiate through 2 molts. In this article, we show that B. malayi depends on an exogenous source of vitamin C to complete the L3 to L4 molt, a critical morphogenic step in its life cycle. Brugia malayi apparently belongs to a small group of living organisms that depend on an exogenous source of vitamin C. This group includes only primates (including man) and guinea pigs among mammals.
authors.affiliation: Department of Pathology, UConn Health Center, Farmington, Connecticut 06030-3105, USA. rajan@neuron.uchc.edu
authors.forename: T V
authors.initials: TV
authors.lastname: Rajan
authors.forename: Natalia
authors.initials: N
authors.lastname: Paciorkowski
authors.forename: Ivo
authors.initials: I
authors.lastname: Kalajzic
authors.forename: Carol
authors.initials: C
authors.lastname: McGuiness
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D001205:Ascorbic Acid / Q000378:metabolism* / Q000494:pharmacology; D017178:Brugia malayi / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D006801:Humans; D007814:Larva / Q000187:drug effects / Q000254:growth & development; D018978:Molting / Q000187:drug effects / Q000502:physiology; D009024:Morphogenesis / Q000187:drug effects / Q000502:physiology
chemical_list: D000975:Antioxidants; D001205:Ascorbic Acid