title: Values of fasting glucose levels, glucose tolerance tests, and glucose-insulin ratios as predictors of glucose tolerance.
abstract: OBJECTIVE
  To examine the ability to use parameters obtainable from an oral glucose tolerance test to predict insulin action as determined under hyperinsulinemic, hyperglycemic conditions.
  
  
  METHODS
  Prospective clinical investigation.
  
  
  METHODS
  University medical center clinical research unit.
  
  
  METHODS
  Healthy male volunteers.
  
  
  METHODS
  Oral glucose tolerance test and hyperglycemic (+125 mg/dL) clamp studies.
  
  
  METHODS
  Glucose and insulin (I) levels, rate of glucose uptake (M) under hyperglycemic conditions, and M/I ratios.
  
  
  RESULTS
  Among individuals with normal glucose tolerance, as assessed by an oral glucose tolerance test, the fasting insulin level is the glucose tolerance test parameter that correlates best with insulin action during a hyperglycemic clamp.
  
  
  CONCLUSIONS
  Measurement of fasting serum insulin levels in conjunction with an oral glucose tolerance test improves the ability to assess insulin action. Such combinations may improve the ability to diagnose insulin-resistant states.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University/Detroit Medical Center, Hutzel Hospital, Detroit, Michigan 48201, USA. mdiamond@med.wayne.edu
authors.forename: Michael P
authors.initials: MP
authors.lastname: Diamond
authors.forename: Subodhsingh
authors.initials: S
authors.lastname: Chauhan
authors.forename: Michael
authors.initials: M
authors.lastname: Kruger
authors.forename: Marappa
authors.initials: M
authors.lastname: Subramanian
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D005215:Fasting / Q000097:blood*; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D006946:Hyperinsulinism / Q000097:blood*; D007328:Insulin / Q000097:blood*; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D007328:Insulin