Back to (non)-basics: recent developments in neutral and charge-balanced glycosidase inhibitors.
Certain glycosidase inhibitors possess potent antiviral, antitumour and antidiabetic properties. Glyconic acid lactones, the earliest glycosidase inhibitors identified, have planar anomeric carbons that mimic the transition state of glycoside hydrolysis. Other classes include lactams, glycals, epoxides, halides and sulfonium ions, the latter based on the natural product salacinol from an antidiabetic herb.
Houston
Todd A
TA
School of Science, Griffith University, Nathan, QLD 4111, Australia. T.Houston@griffith.edu.au
Blanchfield
Joanne T
JT
D000818:Animals; D002241:Carbohydrates / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D006801:Humans; D006868:Hydrolysis; D018716:Molecular Mimicry
D002241:Carbohydrates; D004791:Enzyme Inhibitors; D006026:Glycoside Hydrolases