The effects of anxiogenic stress on glucocorticoid sensitivity, glucose tolerance, and alloxan resistance in rats.
Four sessions of immobilization stress induced anxiogenic behavioral disorders in rats, which were accompanied by decreases in glucocorticoid sensitivity, increases in MAO-B activity in brain tissue, increases in tolerance to glucose loading, and decreases in resistance to acute hypoxia. Alloxan diabetes was accompanied by a decrease in behavioral activity of rats in the open field test, with an increase in cerebral MAO-B activity. Preceding anxiogenic stress increased the extent of the alloxan-induced increase in cerebral MAO-B activity and the accompanying abnormalities in the rats' behavior, and also potentiated the hyperglycemic effect of alloxan.
Volchegorskii
I A
IA
Department of General, Bioorganic Chemistry and Biochemistry ,Chelyabinsk State Medical Academy.
Tseilikman
V E
VE
Ship
S A
SA
Bubnov
N V
NV
Sinitskii
A I
AI
D000496:Alloxan / Q000494:pharmacology; D000818:Animals; D001007:Anxiety / Q000503:physiopathology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D005938:Glucocorticoids / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism; D008995:Monoamine Oxidase / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*
D005938:Glucocorticoids; D000496:Alloxan; D008995:Monoamine Oxidase; D005947:Glucose