title: A big step in the study of small cell lung cancer.
abstract: A rationally designed, conditional p53 and Rb allele-based and lung-targeted mouse model of human small cell lung cancer (SCLC) provides the cancer research community with a valid and important new tool to use in translational research against this deadly disease.
authors.affiliation: Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. john.minna@utsouthwestern.edu
authors.forename: John D
authors.initials: JD
authors.lastname: Minna
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Kurie
authors.forename: Tyler
authors.initials: T
authors.lastname: Jacks
mesh_terms: D000483:Alleles; D000818:Animals; D018288:Carcinoma, Small Cell / Q000235:genetics* / Q000473:pathology; D016161:Genes, Retinoblastoma / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D051379:Mice; D023421:Models, Animal; D009154:Mutation; D009362:Neoplasm Metastasis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D016159:Tumor Suppressor Protein p53