title: Isosteric phosphonate pyrrolidine-based dinucleoside monophosphate analogues.
abstract: A novel alpha- and beta-configured pyrrolidine nucleoside phosphonates in adenine series were synthesized from trans-4-hydroxy-L-proline as starting material. d(ApA) analogues were also prepared and studied with respect to their hybridization properties with polyU.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague, Czech Republic.
authors.forename: Václav
authors.initials: V
authors.lastname: Vanek
authors.forename: Milos
authors.initials: M
authors.lastname: Budesínský
authors.forename: Ivana
authors.initials: I
authors.lastname: Kavenová
authors.forename: Markéta
authors.initials: M
authors.lastname: Rinnová
authors.forename: Ivan
authors.initials: I
authors.lastname: Rosenberg
mesh_terms: D000241:Adenosine / Q000737:chemistry; D001665:Binding Sites; D015226:Dinucleoside Phosphates / Q000737:chemistry*; D006909:Hydroxyproline; D007202:Indicators and Reagents; D009711:Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis; D063065:Organophosphonates / Q000737:chemistry*; D011072:Poly U / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D015226:Dinucleoside Phosphates; D007202:Indicators and Reagents; D009711:Nucleotides; D009841:Oligonucleotides; D063065:Organophosphonates; D011759:Pyrrolidines; D011072:Poly U; D000241:Adenosine; D006909:Hydroxyproline