title: Observations of rat ovarian-splenic consecutive transplants.
abstract: We examined the results after implantation of ovarian follicles by various modes in a total of 82 cases. One or five ovarian follicles were implanted into spleens in castrated female rats. In 20 cases among these, each five follicles were implanted into native and transplanted spleens after spleen transplantation (double implantation of the ovary). Through consecutive spleen transplantation, we observed the results beyond the rat's life span for a limited period. In many cases, we found a more aggressive form of malignant tumor, i.e., dysgerminoma. We present the results and discuss the modes of implantations and possible pathogenetic mechanisms of tumor formation.
authors.affiliation: San Diego Microsurgical Institute, San Diego, California 92103, USA.
authors.forename: I C
authors.initials: IC
authors.lastname: Hong
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: C H
authors.initials: CH
authors.lastname: Yoo
authors.forename: S
authors.initials: S
authors.lastname: Nam
authors.forename: S
authors.initials: S
authors.lastname: Bai
authors.forename: K
authors.initials: K
authors.lastname: Kim
authors.forename: C D
authors.initials: CD
authors.lastname: Pivetti
authors.forename: S T
authors.initials: ST
authors.lastname: Niewiadomski
authors.forename: P
authors.initials: P
authors.lastname: Wolf
authors.forename: R F
authors.initials: RF
authors.lastname: Gittes
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D004407:Dysgerminoma / Q000503:physiopathology*; D005260:Female; D023421:Models, Animal; D016377:Organ Transplantation / Q000379:methods; D006080:Ovarian Follicle / Q000503:physiopathology / Q000637:transplantation*; D010051:Ovarian Neoplasms / Q000503:physiopathology*; D010052:Ovariectomy; D051381:Rats; D011917:Rats, Inbred Lew; D012086:Reoperation; D013154:Spleen / Q000637:transplantation*