title: Effects of vanadyl sulfate on kidney in experimental diabetes.
abstract: The aim of this work was to investigate the biochemical and histological effects of vanadyl sulfate on blood glucose, urea, and creatinine in serum and nonenzymatic glycosylation and glutathione levels in kidney tissue of normal and streptozotocin (65 mg/kg) diabetic rats. Vanadyl sulfate was administered by gavage at a dose of 100 mg/kg. After 60 d of treatment, serum urea, creatinine, and blood glucose levels significantly increased in the diabetic group but not so in the vanadyl sulfate, which showed significantly reduced serum urea and blood glucose levels and a nonsignificant reduction of serum creatinine levels. Nonenzymatic glycosylation was increased and the glutathione level was decreased in the kidney tissue of diabetic rats. Treatment with vanadyl sulfate reversed these effects. Degenerative changes were detected in diabetic animals by electron and light microscopy. Although there are individual differences in diabetic animals given vanadium, some reduction of degenerative changes were observed.
authors.affiliation: Department of Chemistry, Faculty of Engineering, Istanbul University, 34850 Avcilar, Turkey.
authors.forename: Refiye
authors.initials: R
authors.lastname: Yanardag
authors.forename: Sehnaz
authors.initials: S
authors.lastname: Bolkent
authors.forename: Omür
authors.initials: O
authors.lastname: Karabulut-Bulan
authors.forename: Sevim
authors.initials: S
authors.lastname: Tunali
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D005632:Fructose / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006031:Glycosylation / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D014508:Urea / Q000097:blood; D017968:Vanadium Compounds / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D017968:Vanadium Compounds; D005632:Fructose; C034028:vanadyl sulfate; D014508:Urea; D003404:Creatinine; D005978:Glutathione