Intracellular Ca2+ release and ischemic axon injury: the Trojan horse is back.
Ischemic injury of cells in the central nervous system is typically set in motion by influx of extracellular Ca(2+). In this issue of Neuron, Stys and colleagues propose that ischemic injury in spinal cord axons is partly the result of ryanodine receptor-mediated release of Ca(2+) from the endoplasmic reticulum (ER), a site of intracellular Ca(2+) storage.
Ransom
Bruce R
BR
Department of Neurology, University of Washington Medical School, Seattle, WA 98195, USA.
Brown
Angus M
AM
D000818:Animals; D001369:Axons / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D015687:Cell Hypoxia / Q000502:physiology; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism*
D002118:Calcium