Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma.
Expression profiling has demonstrated that transcriptomes of primary malignancies differ from those in normal tissue. It is unknown, however, whether there exist "surrogate" transcriptional markers in peripheral blood mononuclear cells (PBMCs) of patients with solid tumors. We identified transcripts expressed differentially between PBMCs from renal cell carcinoma patients and normal subjects, some of which appear to reflect specific immune responses of circulating cells. We also identified small sets of predictor genes distinguishing PBMCs from renal cell carcinoma patients and normal volunteers with high accuracy. The present findings have important implications for diagnosis and future clinical pharmacogenomic studies of antitumor therapies.
Twine
Natalie C
NC
Discovery Medicine, Wyeth Research, Cambridge, Massachusetts 02140, USA.
Stover
Jennifer A
JA
Marshall
Bonnie
B
Dukart
Gary
G
Hidalgo
Manuel
M
Stadler
Walter
W
Logan
Theodore
T
Dutcher
Janice
J
Hudes
Gary
G
Dorner
Andrew J
AJ
Slonim
Donna K
DK
Trepicchio
William L
WL
Burczynski
Michael E
ME
D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000145:classification / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000235:genetics; D007680:Kidney Neoplasms / Q000097:blood* / Q000145:classification / Q000235:genetics*; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000096:biosynthesis / Q000097:blood / Q000235:genetics; D014158:Transcription, Genetic
D012333:RNA, Messenger