title: The AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with accumulation of immature CD11bHi dendritic cells.
abstract: CD4C/human immunodeficiency virus (HIV) transgenic mice develop an AIDS-like disease. We used this model to study the effects of HIV-1 on dendritic cells (DC). We found a progressive decrease in total DC numbers in the lymph nodes, with a significant accumulation of CD11b(Hi) DC. In the thymus, the recovery of transgenic CD8alpha(+) DC had a tendency to be lower. Spleen DC were augmented in the marginal zone. Transgenic DC showed a decreased capacity to present antigen in vitro, consistent with their reduced major histocompatibility complex class II expression and impaired maturation profile. The accumulation of immature DC may contribute to disease and may reflect an adaptive advantage for the virus by favoring its replication and preventing the generation of fully functional antiviral responses.
authors.affiliation: Laboratory of Molecular Biology, Clinical Research Institute of Montréal, Montréal, Québec H2W 1R7, Canada. jolicop@ircm.qc.ca
authors.forename: Johanne
authors.initials: J
authors.lastname: Poudrier
authors.forename: Xiaoduan
authors.initials: X
authors.lastname: Weng
authors.forename: Denis G
authors.initials: DG
authors.lastname: Kay
authors.forename: Zaher
authors.initials: Z
authors.lastname: Hanna
authors.forename: Paul
authors.initials: P
authors.lastname: Jolicoeur
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D001854:Bone Marrow Cells / Q000276:immunology; D039481:CD11b Antigen / Q000032:analysis*; D015704:CD4 Antigens / Q000235:genetics / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology* / Q000821:virology; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D013154:Spleen / Q000166:cytology / Q000276:immunology; D019076:Transgenes
chemical_list: D039481:CD11b Antigen; D015704:CD4 Antigens