Cortical changes in cholecystokinin mRNA are related to spontaneous pain behaviors following excitotoxic spinal cord injury in the rat.
Cholecystokinin (CCK) in the CNS antagonizes the opioid system and has been implicated post-spinal cord injury (SCI) pain. The current study found that excitotoxic SCI alters levels of CCK mRNA levels in the cortex, diencepahlon, and mesencephalon of rats. Animals that developed pain post-SCI had significantly higher levels than animals that did not develop pain. Upregulation of CCK mRNA in the cortex may be related to post-SCI pain in rats.
Brewer
Kori L
KL
Department of Emergency Medicine, The Brody School of Medicine at East Carolina University, Division of Research, Physician's Quadrangle, Building M, Greenville NC 27858, USA. brewerk@mail.ecu.edu
McMillan
David
D
Nolan
Todd
T
Shum
Kerry
K
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D002540:Cerebral Cortex / Q000378:metabolism*; D002766:Cholecystokinin / Q000235:genetics*; D004027:Diencephalon / Q000378:metabolism; D004195:Disease Models, Animal; D004525:Efferent Pathways / Q000378:metabolism / Q000503:physiopathology; D006120:Grooming / Q000502:physiology; D006179:Gyrus Cinguli / Q000378:metabolism / Q000503:physiopathology; D008636:Mesencephalon / Q000378:metabolism; D009473:Neuronal Plasticity / Q000235:genetics; D009474:Neurons / Q000378:metabolism; D018847:Opioid Peptides / Q000037:antagonists & inhibitors / Q000378:metabolism; D010146:Pain / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D013119:Spinal Cord Injuries / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D015854:Up-Regulation / Q000235:genetics*
D018847:Opioid Peptides; D012333:RNA, Messenger; D002766:Cholecystokinin