title: High-grade dysplasia in sporadic fundic gland polyps: a case report and review of the literature.
abstract: We present a case of fundic gland polyps (FGPs) containing high-grade dysplasia in a 68-year-old man. High-grade dysplasia, and even gastric adenocarcinoma, associated with FGPs have been described in patients with familial adenomatous polyposis (FAP) and attenuated familial adenomatous polyposis (AFAP) but never in non-FAP patients. Two colonoscopies in the past six years virtually rule out FAP and AFAP in our patient. Dysplasia in FGPs from non-FAP patients is extremely rare, and until now only cases of low-grade dysplasia have been described. The literature on dysplasia in FGPs is reviewed briefly. Additional immunohistochemical investigations in this case showed nuclear staining of beta-catenin, increased proliferation and apoptosis in the dysplastic areas of the FGPs. Our case suggests that the malignant potential of FGPs is not limited to FAP-associated FGPs.
authors.affiliation: Department of Gastroenterology and Hepatology, University Hospital Groningen, Groningen, the Netherlands.
authors.forename: Mathilde
authors.initials: M
authors.lastname: Jalving
authors.forename: Jan J
authors.initials: JJ
authors.lastname: Koornstra
authors.forename: Jan M
authors.initials: JM
authors.lastname: Götz
authors.forename: Laurens A
authors.initials: LA
authors.lastname: van der Waaij
authors.forename: Steven
authors.initials: S
authors.lastname: de Jong
authors.forename: Nynke
authors.initials: N
authors.lastname: Zwart
authors.forename: Arend
authors.initials: A
authors.lastname: Karrenbeld
authors.forename: Jan H
authors.initials: JH
authors.lastname: Kleibeuker
mesh_terms: D000368:Aged; D017209:Apoptosis; D002278:Carcinoma in Situ / Q000150:complications / Q000473:pathology*; D002467:Cell Nucleus / Q000737:chemistry; D003598:Cytoskeletal Proteins / Q000032:analysis; D005748:Gastric Fundus; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D011127:Polyps / Q000150:complications / Q000473:pathology*; D013274:Stomach Neoplasms / Q000150:complications / Q000473:pathology*; D015534:Trans-Activators / Q000032:analysis; D051176:beta Catenin
chemical_list: C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D015534:Trans-Activators; D051176:beta Catenin