title: An analysis of a puncture wound case with medical intervention.
abstract: A worker noted a small wound to his thumb when leaving a work site that was undergoing decontamination because of past operations with plutonium (Pu) and americium (Am). Direct surveys of the wound site confirmed the presence of contamination. The chelating agent Ca-DTPA was administered via a nebuliser within an hour after discovery of the wound. External measurements were made of the wound site and wound dressings; 24-h urinary excretion data were collected periodically and the Pu and Am urine content was determined. Zn-DTPA was administered on three occasions. The ICRP Pu systemic model was modified to consider the enhanced urinary excretion following administration of the chelating agents. The analysis indicated that the wound resulted in an initial deposition of 400 Bq 238Pu, 2240 Bq (239/240)Pu and 1060 Bq 241Am. About 70% of the initial wound activity was removed by surgical procedures and less than 1% of the wound activity was removed by chelation therapy. This paper compares the observed urinary excretion data with that indicated by a simulation of the kinetics of the transfer from the wound site and the kinetics of the chelating agent and Pu.
authors.affiliation: Nuclear Engineering Dept., University of Tennessee, Knoxville, TN 37996, USA.
authors.forename: B R
authors.initials: BR
authors.lastname: Bailey
authors.forename: K F
authors.initials: KF
authors.lastname: Eckerman
authors.forename: L W
authors.initials: LW
authors.lastname: Townsend
mesh_terms: D000280:Administration, Inhalation; D000287:Administration, Topical; D000576:Americium / Q000032:analysis / Q000493:pharmacokinetics* / Q000652:urine; D002614:Chelating Agents / Q000627:therapeutic use; D015913:Chelation Therapy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D004369:Pentetic Acid / Q000627:therapeutic use*; D011005:Plutonium / Q000032:analysis / Q000493:pharmacokinetics* / Q000652:urine; D011832:Radiation Injuries / Q000139:chemically induced / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D013933:Thumb / Q000293:injuries / Q000601:surgery; D014915:Whole-Body Counting; D014950:Wounds, Penetrating / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism* / Q000601:surgery
chemical_list: D002614:Chelating Agents; D011005:Plutonium; D004369:Pentetic Acid; D000576:Americium