title: Synthesis and antiviral evaluation of 2',3'-dideoxy-2'-fluoro-3'- C-hydroxymethyl-beta-D-arabinofuranosyl pyrimidine nucleosides.
abstract: The synthesis and anti-HBV and anti-HIV activity of a number of 2',3'-dideoxy-2'-fluoro-3'-C-hydroxymethyl-beta-D-arabinofuranosyl pyrimidine nucleosides are reported.
authors.affiliation: Pharmasset Inc., Tucker, Georgia 30084, USA. ahassan@services.pharmasset.com
authors.forename: Abdalla E A
authors.initials: AE
authors.lastname: Hassan
authors.forename: Balakrina S
authors.initials: BS
authors.lastname: Pai
authors.forename: Stefania
authors.initials: S
authors.lastname: Lostia
authors.forename: Lieven
authors.initials: L
authors.lastname: Stuyver
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Otto
authors.forename: Raymond F
authors.initials: RF
authors.lastname: Schinazi
authors.forename: Kyoichi A
authors.initials: KA
authors.lastname: Watanabe
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006678:HIV / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects; D007202:Indicators and Reagents; D008968:Molecular Conformation; D015394:Molecular Structure; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D007202:Indicators and Reagents; D011741:Pyrimidine Nucleosides