title: Design, synthesis, and in vitro evaluation of APIO analogue of neplanocin A.
abstract: A novel apio analogue of neplanocin A was efficiently synthesized from D-ribose via stereoselective aldol-retroaldol reaction for introducing hydroxymethyl group and RCM reaction for synthesizing carbocycle, and its inhibitory activity against SAH hydrolase was assayed.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seoul, South Korea.
authors.forename: Hyung Ryong
authors.initials: HR
authors.lastname: Moon
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Kwon
authors.forename: Jeong Ah
authors.initials: JA
authors.lastname: Lee
authors.forename: Byul Nae
authors.initials: BN
authors.lastname: Yoo
authors.forename: Hea Ok
authors.initials: HO
authors.lastname: Kim
authors.forename: Moon Woo
authors.initials: MW
authors.lastname: Chun
authors.forename: Hee-Doo
authors.initials: HD
authors.lastname: Kim
authors.forename: Joong Hyup
authors.initials: JH
authors.lastname: Kim
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D043383:Adenosylhomocysteinase / Q000037:antagonists & inhibitors*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; C031096:neplanocin A; D043383:Adenosylhomocysteinase; D000241:Adenosine