Synthesis and DNA binding properties of DNA-PNA chimeras.
A systematic study to evaluate the ability of 5'-DNA-3'-p-(N)-PNA-(C) chimeras to form triple helix structures has been undertaken. Preliminary results carried out on a 16-mer chimera with three PNA monomers at the 3'-end showed the formation of a stable DNA-PNA/DNA/DNA triplex, having similar conformational behaviour to a canonical DNA/DNA/DNA triplex.
Barone
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G
Dipartimento di Chimica, Università degli Studi di Napoli Federico II, Napoli, Italy.
De Napoli
L
L
Di Fabio
G
G
Erra
E
E
Giancola
C
C
Messere
A
A
Montesarchio
D
D
Petraccone
L
L
Piccialli
G
G
D001665:Binding Sites; D002678:Chimera; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry*
D009838:Oligodeoxyribonucleotides; D020135:Peptide Nucleic Acids; D004247:DNA