title: Intraocular lens with reversibly adjustable optical power: pilot study of concept and safety.
abstract: OBJECTIVE
  To evaluate whether it is technically feasible and safe to implant and adjust an intraocular lens (IOL) with reversibly adjustable refractive power designed to correct residual postoperative refractive error.
  
  
  METHODS
  Animal study facility, Klinikum Mannheim, University of Heidelberg, Heidelberg, Germany.
  
  
  METHODS
  An Acri.Tec AR-1 posterior chamber IOL (PC IOL) was implanted in pig cadaver eyes and in rabbit eyes after the crystalline lens was removed by phacoemulsification. The IOL was manipulated to change the refractive power. The outcome measures were the stability of the IOL during implantation, IOL positioning and rotation, the ability to move the adjustment device after the IOL had been implanted for several weeks, clinical signs of inflammation, and changes in the histopathologic appearance of the eye.
  
  
  RESULTS
  Implantation and adjustment of refractive power were possible. The eyes healed normally. There was no difference between eyes with the AR-1 PC IOL and eyes with a control IOL in inflammatory reaction, corneal transparency, or histopathologic appearance.
  
  
  CONCLUSIONS
  The AR-1 PC IOL was easy to implant and well tolerated in rabbit eyes. Surgical adjustment of the adjusting element was performed with little effort several weeks after implantation of the IOL.
authors.affiliation: Augenpraxisklinik Dr. Jahn, Kempten, Germany. praxisdrjahn@t-online.de
authors.forename: Claus E
authors.initials: CE
authors.lastname: Jahn
authors.forename: Marianne A
authors.initials: MA
authors.lastname: Jahn
authors.forename: Christine F
authors.initials: CF
authors.lastname: Kreiner
authors.forename: Alexander
authors.initials: A
authors.lastname: Serester
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Fromberg
authors.forename: Susan
authors.initials: S
authors.lastname: Jacobi
authors.forename: Siegfried
authors.initials: S
authors.lastname: Deutschmann
authors.forename: Ekkehard H
authors.initials: EH
authors.lastname: Schäffer
authors.forename: Bernd A
authors.initials: BA
authors.lastname: Kamppeter
mesh_terms: D000818:Animals; D004867:Equipment Design; D066298:In Vitro Techniques; D007498:Iris / Q000473:pathology; D019654:Lens Implantation, Intraocular / Q000295:instrumentation; D007910:Lenses, Intraocular / Q000009:adverse effects; D055095:Optics and Photonics; D010865:Pilot Projects; D011817:Rabbits; D012449:Safety; D013552:Swine