[A study on genetic epidemiology of cerebral infarction].
OBJECTIVE
To explore the genetic model of cerebral infarction and to examine the relationship between cerebral infarction and genetic factor.


METHODS
A matched case-control study including 112 pairs pedigrees was carried out. Using the Li-Mantel-Gart method and the Falconer method to estimate the segregation ratio and the heritability of cerebral infarction.


RESULTS
The prevalence rate of the first-degree and the second-degree relatives in cases was significantly higher than that in controls. The segregation ratio was 0.143 7 (0.113 0 - 0.174 4), significantly lower than 0.25, which showed that cerebral infarction did not possess the characteristics of monogenetic model. The results showed that the heritability of the first-degree and the second-degree relatives were 47.84% and 40.95% higher in male's than in female's.


CONCLUSIONS
Cerebral infarction was a polygenetic disease, and the genetic factors played an important role in the occurrence of cerebral infarction, especially in males.
Shi
Bao-lin
BL
The Public Health Section, Zhangjiakou Medical College, Zhangjiakou 075029, China.
Zhang
Yong
Y
Wu
Yan-hua
YH
Zhang
Jie
J
D000368:Aged; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000453:epidemiology* / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence