title: Effect of conversion from cyclosporine A to mizoribine on transplant arteriosclerosis in rat aortic allograft models.
abstract: Recent studies suggested that conversion from cyclosporine A (CsA) to antimetabolic agents protects allograft vasculopathy. However, the mechanism of this beneficial effect by the conversion therapy is not fully understood. In the present study, we investigated the effects of conversion from CsA to antimetabolic agent mizoribine (MZR) on the formation of transplant arteriosclerosis in rat aortic allografts. Conversion from CsA to MZR significantly prevented intimal hyperplasia and perivascular inflammatory cell infiltration at 28 days after aortic transplantation. These findings suggest that conversion therapy from CsA to antimetabolic agents might have therapeutic potential in transplant patients with chronic vascular rejection.
authors.affiliation: Division of Organ Replacement Research, Center for Molecular Medicine, Jichi Medical School, Minamikawachi-machi, Tochigi, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shimizu
authors.forename: Masafumi
authors.initials: M
authors.lastname: Takahashi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takeda
authors.forename: Kazunori
authors.initials: K
authors.lastname: Tahara
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Inoue
authors.forename: Yoji
authors.initials: Y
authors.lastname: Hakamata
authors.forename: Takashi
authors.initials: T
authors.lastname: Kaneko
authors.forename: Izumi
authors.initials: I
authors.lastname: Takeyoshi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Morishita
authors.forename: Eiji
authors.initials: E
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000276:immunology / Q000637:transplantation*; D001161:Arteriosclerosis / Q000276:immunology*; D016572:Cyclosporine / Q000494:pharmacology*; D006965:Hyperplasia / Q000276:immunology / Q000517:prevention & control; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D023421:Models, Animal; D051381:Rats; D011917:Rats, Inbred Lew; D012263:Ribonucleosides / Q000494:pharmacology*; D014181:Transplantation Immunology / Q000187:drug effects / Q000276:immunology; D017539:Tunica Intima / Q000187:drug effects / Q000473:pathology*
chemical_list: D007166:Immunosuppressive Agents; D012263:Ribonucleosides; C010052:mizoribine; D016572:Cyclosporine