Transient up-regulation of retinal EphA3 and EphA5, but not ephrin-A2, coincides with re-establishment of a topographic map during optic nerve regeneration in goldfish.
Eph tyrosine kinase receptors and their ligands, the ephrins, play a key role in the establishment of retinotectal topography during development. Tectal up-regulation of ephrin-A2 in goldfish, coincident with the reestablishment of a retinotectal map, suggests a similar role during optic nerve regeneration. Here we report a complementary study of EphA3, EphA5 and ephrin-A2 expression in the retina. EphA3 and EphA5 are transiently up-regulated as ascending naso-temporal gradients, whereas ephrin-A2 remains uniform. The expression profiles differ from those in developing chick and mouse, suggesting that different combinations of retinal Eph receptors and ligands can generate topographic guidance information.
King
Carolyn E
CE
Neurobiology Laboratory, Department of Zoology, The University of Western Australia, 6907, Western, Nedlands, Australia. ceking@cyllene.uwa.edu.au
Wallace
Amy
A
Rodger
Jennifer
J
Bartlett
Carole
C
Beazley
Lyn D
LD
Dunlop
Sarah A
SA
D025042:Amacrine Cells / Q000378:metabolism; D000818:Animals; D036383:Ephrin-A2 / Q000096:biosynthesis; D036384:Ephrin-A3 / Q000378:metabolism; D036386:Ephrin-A5 / Q000378:metabolism; D036342:Ephrins / Q000378:metabolism*; D006054:Goldfish / Q000502:physiology*; D009409:Nerve Crush; D009416:Nerve Regeneration / Q000502:physiology*; D009900:Optic Nerve / Q000473:pathology / Q000502:physiology*; D020221:Optic Nerve Injuries / Q000473:pathology / Q000503:physiopathology; D012160:Retina / Q000378:metabolism*; D012165:Retinal Ganglion Cells / Q000378:metabolism; D013997:Time Factors; D015854:Up-Regulation
D036383:Ephrin-A2; D036384:Ephrin-A3; D036386:Ephrin-A5; D036342:Ephrins