Prenatal management of gastroschisis: the place of the amnioexchange procedure.
Gastroschisis is a malformation of the anterior abdominal wall that consists of a right paraumbilical defect with bowel loops bathed in the amniotic fluid. The survival rate is now greater than 90% and the prognosis relies mainly on morbidity attributable to bowel dysfunction. Recent research has examined gastrointestinal waste present in amniotic fluid that induces bowel toxicity and an inflammatory process. The amnioexchange procedure (changing the amniotic fluid regularly) involves a new therapeutic approach: reducing bowel injuries in the fetuses. This article shows that there is an inflammatory reaction in human gastroschisis and in the authors' model, and that the clinical and biological data plead for the practice of amnioexchange in human beings. A randomized, controlled study is now needed.
Luton
D
D
Université Paris VII (UFR Lariboisière Saint Louis), France. dominique.luton@rdb.ap-hop-paris.fr
Guibourdenche
J
J
Vuillard
E
E
Bruner
J
J
de Lagausie
P
P
D000653:Amniotic Fluid; D000818:Animals; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000628:therapy*; D020139:Gastroschisis / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D007267:Injections; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012965:Sodium Chloride / Q000008:administration & dosage
D012965:Sodium Chloride