title: A randomised comparison of side effects and patient inconvenience of two vaginal progesterone formulations used for luteal support in in vitro fertilisation cycles.
abstract: OBJECTIVE
  To compare side effects and patient inconvenience of two vaginal progesterone (P) formulations for luteal support in in vitro fertilisation cycles.
  
  
  METHODS
  Sixty infertile patients at risk of developing ovarian hyperstimulation syndrome were randomised to receive either Cyclogest vaginal suppositories 400mg twice daily or Crinone 8% vaginal gel once daily for 14 days as the luteal support. On Day 6 and Day 16 after embryo transfer, they rated side effects and patient inconvenience into four grades: none, mild, moderate and severe by completing a questionnaire.
  
  
  RESULTS
  Perineal irritation was reported by about 20% of patients in each group. Significantly more patients using Cyclogest suppositories graded inconvenience of administration, leaking out and interference with coitus as moderate or severe.
  
  
  CONCLUSIONS
  There was no difference in perineal irritation after Cyclogest suppositories or Crinone 8% gel although significantly more patients found inconvenience of administration, leaking out and interference with coitus after Cyclogest.
authors.affiliation: Department of Obstetrics and Gynaecology, The University of Hong Kong, 6/F, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong Special Administrative Region, Hong Kong, PR China. nghye@hkucc.hku.hk
authors.forename: Ernest H Y
authors.initials: EH
authors.lastname: Ng
authors.forename: Benyu
authors.initials: B
authors.lastname: Miao
authors.forename: Wai
authors.initials: W
authors.lastname: Cheung
authors.forename: Pak-Chung
authors.initials: PC
authors.lastname: Ho
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D003075:Coitus; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007509:Irritants / Q000009:adverse effects; D008183:Luteal Phase / Q000187:drug effects*; D009325:Nausea / Q000139:chemically induced; D010502:Perineum; D011374:Progesterone / Q000008:administration & dosage* / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: C400424:Crinone; D007509:Irritants; D011374:Progesterone