Possible involvement of apoptotic death of myocytes in left ventricular remodeling after myocardial infarction.
Pathophysiological roles of apoptosis in post-infarction left ventricular (LV) remodeling have not been well characterized. This study showed that TUNEL- or cleaved caspase-3-positive myocytes were identified late after ligation of the left coronary artery in rats, suggesting that apoptotic myocyte death contributed to the morphological change associated with LV remodeling.
Saitoh
Tadashi
T
Laboratory of Biomedical Control, Research Institute for Electronic Science, Hokkaido University, Sapporo, 060-0812 Japan.
Nakajima
Takayuki
T
Kawahara
Koichi
K
D000818:Animals; D017209:Apoptosis; D001158:Arteries; D053148:Caspase 3; D020169:Caspases / Q000737:chemistry / Q000378:metabolism; D003331:Coronary Vessels; D020287:In Situ Nick-End Labeling; D008026:Ligation; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology*; D032383:Myocytes, Cardiac; D009336:Necrosis; D051381:Rats; D017208:Rats, Wistar; D020257:Ventricular Remodeling
C505410:Casp3 protein, rat; D053148:Caspase 3; D020169:Caspases