Bi- and tricyclic nucleoside derivatives restricted in S-type conformations and obtained by RCM-reactions.
Ring-closing metathesis (RCM) is applied as a new and powerful technology in the construction of nucleoside analogues that are conformationally restricted in S-type conformations due to additional 3',4'- and/or 3',5'-linkages.
Albaek
Nanna
N
Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark.
Ravn
Jacob
J
Freitag
Morten
M
Thomasen
Helena
H
Christensen
Nanna K
NK
Petersen
Michael
M
Nielsen
Poul
P
D002625:Chemistry, Organic / Q000379:methods; D008958:Models, Molecular; D008968:Molecular Conformation; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry*
D009705:Nucleosides