title: [Relationship between aberrant FHIT transcripts and hepatocellular carcinoma].
abstract: OBJECTIVE
  To study the relationship between aberrant FHIT transcripts and hepatocellular carcinoma (HCC).
  
  
  METHODS
  Reverse transcription-polymerase chain reaction (RT-PCR) and single strand conformational polymorphism (SSCP) assays were used to analyze the transcripts and mutations of FHIT gene in 24 matched tumorous tissues and para-tumorous tissues from patients with HCC and in 4 normal liver tissues.
  
  
  RESULTS
  Aberrant FHIT transcripts were observed in 11 out of 24 (46%) tumorous tissues and in 2 (8%) of the matched para-tumorous tissues.
  
  
  CONCLUSIONS
  FHIT aberrant transcripts may play an important role in the pathogenesis of hepatocellular carcinoma.
authors.affiliation: Center Laboratory, Railway Hospital Affiliated to Tongji University, Shanghai 200072, China.
authors.forename: Yong-chun
authors.initials: YC
authors.lastname: Yu
authors.forename: Fen-yong
authors.initials: FY
authors.lastname: Sun
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.forename: Shao-yi
authors.initials: SY
authors.lastname: Lu
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Teng
mesh_terms: D017766:Acid Anhydride Hydrolases; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D000099170:Bis(5'-adenosyl)triphosphatase