The evolution of a resistant pathogen--the case of MRSA.
Recent advances in molecular epidemiological methods have elucidated the evolutionary pathways by which modern methicillin-resistant Staphylococcus aureus have evolved. Only five major lineages of hospital methicillin-resistant Staphylococcus aureus exist, but these are globally distributed and evolving resistance to even the newest antibiotics.
Enright
Mark C
MC
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK. m.c.enright@bath.ac.uk
D000818:Animals; D017714:Community-Acquired Infections / Q000188:drug therapy / Q000382:microbiology; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology; D019143:Evolution, Molecular; D006801:Humans; D016106:Methicillin Resistance / Q000235:genetics*; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics*; D020713:Vancomycin Resistance / Q000235:genetics