title: Preparation of 3-acetoacetylaminobenzo[b]furan derivatives with cysteinyl leukotriene receptor 2 antagonistic activity.
abstract: Novel 3-acetoacetylaminobenzo[b]furan derivatives with a modified triene system at the 3-position were prepared through acylation of the 3-aminobenzo[b]furans with 5-methylisoxazole-4-carboxylic acid chloride followed by basic cleavage of the isoxazole ring and several of these compounds showed moderate cysteinyl leukotriene receptor 2 antagonistic activity.
authors.affiliation: School of Pharmaceutical Sciences, Mukogawa-Women's University, 11-68 Koshien Kyuban-cho, Nishinomiya 663-8179, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Tsuji
authors.forename: Kumiko
authors.initials: K
authors.lastname: Ando
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kunitomo
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yamashita
authors.forename: Shunsaku
authors.initials: S
authors.lastname: Ohta
authors.forename: Shigekatsu
authors.initials: S
authors.lastname: Kohno
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Ohishi
mesh_terms: D001249:Asthma / Q000188:drug therapy; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D002625:Chemistry, Organic / Q000379:methods*; D018360:Crystallography, X-Ray; D006801:Humans; D020024:Leukotriene Antagonists; D008565:Membrane Proteins; D008956:Models, Chemical; D008958:Models, Molecular; D018077:Receptors, Leukotriene
chemical_list: D001572:Benzofurans; D020024:Leukotriene Antagonists; D008565:Membrane Proteins; D018077:Receptors, Leukotriene; C412375:cysteinyl leukotriene receptor 2; C105430:benzofuran