title: The proteasome: a novel therapeutic target in haematopoietic malignancy.
abstract: The proteasome plays a key role in regulating protein degradation in eukaryotic cells. A range of synthetic inhibitors of proteasome activity have been developed which have helped elucidate its role in the cell. These inhibitors have selectively induced apoptosis in malignant cells in vitro suggesting that the proteasome may be a novel therapeutic target. First generation proteasome inhibitors are currently showing promise in phase II/III clinical trials for patients with multiple myeloma.
authors.affiliation: Department of Haemotology, Queen's University of Belfast, UK.
authors.forename: Laura
authors.initials: L
authors.lastname: Magill
authors.forename: Brian
authors.initials: B
authors.lastname: Walker
authors.forename: Alexandra E
authors.initials: AE
authors.lastname: Irvine
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000378:metabolism; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D011480:Protease Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D046988:Proteasome Endopeptidase Complex
chemical_list: D009097:Multienzyme Complexes; D011480:Protease Inhibitors; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex