Oligoclonal immunoglobulins in cerebrospinal fluid during varicella zoster virus (VZV) vasculopathy are directed against VZV.
Limited analyses of cerebrospinal fluid from patients with central nervous system infections have shown that the oligoclonal IgG is antibody directed against the agent that causes disease. Using a new method involving binding of IgG to beads coated with lysates prepared from candidate infectious antigens, we showed that the oligoclonal IgG in cerebrospinal fluid of a patient with chronic varicella zoster virus vasculopathy is directed against the causative virus. This approach holds promise in identifying and purifying the relevant oligoclonal IgGs in inflammatory central nervous system diseases of unknown cause.
Burgoon
Mark P
MP
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA. mark.burgoon@uchsc.edu
Hammack
Barbara N
BN
Owens
Gregory P
GP
Maybach
Amy L
AL
Eikelenboom
M Judith
MJ
Gilden
Donald H
DH
D000368:Aged; D002494:Central Nervous System Infections / Q000134:cerebrospinal fluid / Q000276:immunology / Q000821:virology; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006562:Herpes Zoster / Q000276:immunology*; D014645:Herpesvirus 3, Human / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D007136:Immunoglobulins / Q000134:cerebrospinal fluid*; D008297:Male; D043025:Oligoclonal Bands; D013344:Subacute Sclerosing Panencephalitis / Q000134:cerebrospinal fluid / Q000276:immunology; D014652:Vascular Diseases / Q000134:cerebrospinal fluid / Q000276:immunology / Q000821:virology
D007136:Immunoglobulins; D043025:Oligoclonal Bands