title: A functional genetic variation of the 5-HT2a receptor affects human memory.
abstract: Human memory capacity is highly variable across individuals and is influenced by both genetic and environmental factors. A roughly 50% heritability estimate indicates that naturally occurring genetic variations have an important impact on this cognitive ability. Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant.
authors.affiliation: Division of Psychiatry Research, University of Zürich, Lenggstr. 31, 8029 Zürich, Switzerland. quervain@bli.unizh.ch
authors.forename: Dominique J-F
authors.initials: DJ
authors.lastname: de Quervain
authors.forename: Katharina
authors.initials: K
authors.lastname: Henke
authors.forename: Amanda
authors.initials: A
authors.lastname: Aerni
authors.forename: Daniel
authors.initials: D
authors.lastname: Coluccia
authors.forename: M Axel
authors.initials: MA
authors.lastname: Wollmer
authors.forename: Christoph
authors.initials: C
authors.lastname: Hock
authors.forename: Roger M
authors.initials: RM
authors.lastname: Nitsch
authors.forename: Andreas
authors.initials: A
authors.lastname: Papassotiropoulos
mesh_terms: D016022:Case-Control Studies; D014644:Genetic Variation; D005838:Genotype; D006639:Histidine / Q000235:genetics; D008568:Memory / Q000502:physiology*; D009154:Mutation; D011110:Polymorphism, Genetic; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics / Q000502:physiology*; D014443:Tyrosine / Q000235:genetics; D014706:Verbal Learning
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D014443:Tyrosine; D006639:Histidine