HIV resistance to nevirapine and other non-nucleoside reverse transcriptase inhibitors.
Nevirapine and other members of the non-nucleoside reverse transcriptase inhibitor (NNRTI) family of anti-HIV-1 drugs are essential components of antiretroviral treatment regimens. Unfortunately, drug resistance has become an important issue with respect to all therapeutic targets in HIV-1. This paper summarizes current knowledge about the mutations in the reverse transcriptase gene of HIV-1 that are responsible for drug resistance and the mechanisms whereby drug resistance develops.
Wainberg
Mark A
MA
McGill University AIDS Centre, Jewish General Hospital, Montreal, Quebec, Canada. mwainb1@po-box.mcgill.ca
D024882:Drug Resistance, Viral / Q000235:genetics; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D009154:Mutation; D019829:Nevirapine / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*
D018894:Reverse Transcriptase Inhibitors; D019829:Nevirapine