Design and synthesis of A3 adenosine receptor ligands, 2'-fluoro analogues of Cl-IB-MECA.
Synthesis of 2'-deoxy-2'-fluoro-N6-substituted adenosines as bioisosteres of Cl-IB-MECA and their binding affinities to A3 adenosine receptor are described.
Kim
Hea Ok
HO
Division of Chemistry and Molecular Engineering, Seoul National University, Seoul, South Korea.
Park
Jae Gyu
JG
Moon
Hyung Ryong
HR
Gunaga
Prashantha
P
Lim
Moo Hong
MH
Chun
Moon Woo
MW
Jacobson
Kenneth A
KA
Kim
Hee-Doo
HD
Jeong
Lak Shin
LS
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D000818:Animals; D001921:Brain / Q000378:metabolism; D015195:Drug Design; D005459:Fluorides; D006801:Humans; D008024:Ligands; D051381:Rats; D043684:Receptor, Adenosine A3 / Q000378:metabolism*
D008024:Ligands; D043684:Receptor, Adenosine A3; D000241:Adenosine; D005459:Fluorides; C090034:2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide