title: Accumulation of gliotoxin, a cytotoxic mycotoxin from Aspergillus fumigatus, in blue mussel (Mytilus edulis).
abstract: A strain of Aspergillus fumigatus has been isolated from sediments of a mussel bed. When cultured in hyper saline conditions (with sea-water), it produces a cytotoxic and immunosuppressive toxin, gliotoxin, which is excreted in an exudate. In order to know if this toxin could represent a risk for shellfish consumers, an experiment of bioaccumulation of gliotoxin in mussel has been carried out. After 6 days of contamination, toxin was accumulated in the meat of the mussels, at a level up to 2.9 microg/mg of extract weight, with a mode of contamination different to the classical digestive process described for a majority of marine toxins, but similar to the contamination mode of domoic acid.
authors.affiliation: Faculté de Pharmacie, Groupe Substances Marines à Activité Biologique, Université de Nantes, ISOMer, BP 53508, Nantes 01 44035, France.
authors.forename: Olivier
authors.initials: O
authors.lastname: Grovel
authors.forename: Yves François
authors.initials: YF
authors.lastname: Pouchus
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Verbist
mesh_terms: D000818:Animals; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D049872:Bivalvia / Q000737:chemistry / Q000378:metabolism*; D004781:Environmental Exposure / Q000032:analysis*; D004784:Environmental Monitoring; D005506:Food Contamination; D019015:Geologic Sediments / Q000382:microbiology; D005912:Gliotoxin / Q000032:analysis / Q000378:metabolism / Q000493:pharmacokinetics*; D008387:Marine Toxins / Q000032:analysis / Q000493:pharmacokinetics*; D017747:Seafood; D012623:Seawater; D014873:Water Pollutants / Q000032:analysis*
chemical_list: D008387:Marine Toxins; D014873:Water Pollutants; D005912:Gliotoxin