[The new possibilities to control allergic inflammatory processes].
The development of immune or allergic reactions is involved in the induction of inflammation. The apoptotic elimination of responsible cells prevents or diminishes inflammation. In 2002 S. Brenner, J. Sulston and R. Horovitz were awarded the Nobel Prize for the discovery and description of the mechanisms and role of the preset cell death, which already in 1972 was called apoptosis by J. Kerr. Apoptosis plays an important role in growth and development and also maturation processes of the immune system. It is precisely regulated by appropriate genes. Autoreactive T cells are eliminated in the thymus by apoptosis. The depletion of regulatory T cells by deviated reactions of apoptosis may be responsible for the induction of autoimmunity of allergy in view of absence of peripheral tolerance or impairment of regulatory CD4+ and CD25+ function. Induced or directed apoptosis of certain cells may be a useful adjunct to the therapy of allergic diseases.
Tchórzewski
Henryk
H
Zakład Immunologii Klinicznej Instytutu Centrum Zdrowia Matki Polki oraz Zakład Patofizjologii i Immunologii Uniwersytetu Medycznego w Łodzi.
D017209:Apoptosis / Q000502:physiology; D015704:CD4 Antigens / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000503:physiopathology; D007249:Inflammation / Q000276:immunology* / Q000503:physiopathology; D015375:Receptors, Interleukin-2 / Q000276:immunology
D015704:CD4 Antigens; D015375:Receptors, Interleukin-2