title: [Enhancing the cytotoxicity of antitumor drugs through electromagnetic pulses].
abstract: We chose Hela cells as research object and studied the cytotoxicity generated by cyclophosphamide, an antitumor drug, after cell electroporation by the use of electromagnetic pulses. Comparison between the electroporation group and the contrast group revealed the greatly enhanced cytotoxicity of the electroporation group, indicating that under some conditions electromagnetic pulses can enhance the cytotoxicity of antitumor drugs. The results of this study provide reliable evidences and a feasible approach for clinical treatment of tumor.
authors.affiliation: Department of Radio Electronics, Sichuan University, Chengdu 610064.
authors.forename: Guo
authors.initials: G
authors.lastname: Yang
authors.forename: Baoyi
authors.initials: B
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Haichuan
authors.initials: H
authors.lastname: Chen
authors.forename: Zishu
authors.initials: Z
authors.lastname: Wang
authors.forename: Kong
authors.initials: K
authors.lastname: Yang
authors.forename: Jingru
authors.initials: J
authors.lastname: Sun
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D002470:Cell Survival / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D055590:Electromagnetic Phenomena; D018274:Electroporation / Q000379:methods*; D006367:HeLa Cells; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D003520:Cyclophosphamide