Total synthesis and absolute configuration of otteliones A and B, novel and potent antitumor agents from a freshwater plant.
[reaction: see text] The first enantioselective total synthesis of otteliones A and B, biologically important and structurally novel natural products, has been successfully achieved. This total synthesis fully confirms the absolute configuration of these natural products.
Araki
Hiroshi
H
Department of Electronic Chemistry, Tokyo Institute of Technology, Nagatsuta, Yokohama 226-8502, Japan.
Inoue
Munenori
M
Katoh
Tadashi
T
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D003512:Cyclohexanones / Q000138:chemical synthesis*; D031321:Hydrocharitaceae / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D013237:Stereoisomerism
D000972:Antineoplastic Agents, Phytogenic; D003512:Cyclohexanones; C468748:ottelione A; C468747:ottelione B