DNA-templated metal catalysis.
Hydrolysis of an ester substrate by a CuII complex catalyst, both attached to oligo-peptide nucleic acids (PNA), is accelerated up to 485-fold in the presence of a complementary DNA template. The approach combines the sequence selectivity of DNA-templated reactions with signal amplification by multiple turnover and the versatility of metal catalysis.
Brunner
Jens
J
Anorganisch-Chemisches Institut, Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg, Germany.
Mokhir
Andriy
A
Kraemer
Roland
R
D002384:Catalysis; D002413:Cations, Divalent / Q000737:chemistry; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D007700:Kinetics; D009942:Organometallic Compounds / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000737:chemistry
D002413:Cations, Divalent; D009942:Organometallic Compounds; D020135:Peptide Nucleic Acids; D003300:Copper; D004247:DNA