Urinary modified nucleosides as tumor markers.
Extracts of urinary nucleosides have been sequentially purified and examined by mass spectrometric analysis. Seventeen modified nucleosides have been unequivocally identified and a further five provisionally identified. While several nucleosides were found only in a small number of extracts, the occurrence and levels of others were found to correlate with the tumour type and stage.
Dudley
E
E
Biochemistry Group, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea, UK.
Lemiere
F
F
Van Dongen
W
W
Esmans
E
E
El-Sharkawi
A M M
AM
Games
D E
DE
Brenton
A G
AG
Newton
R P
RP
D014408:Biomarkers, Tumor / Q000737:chemistry / Q000302:isolation & purification / Q000652:urine*; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D013058:Mass Spectrometry; D009367:Neoplasm Staging; D009369:Neoplasms / Q000473:pathology / Q000652:urine; D009705:Nucleosides / Q000737:chemistry / Q000302:isolation & purification / Q000652:urine*
D014408:Biomarkers, Tumor; D009705:Nucleosides