title: Escherichia coli bind to urinary bladder epithelium through nonspecific sialic acid mediated adherence.
abstract: The first step in the bacterial colonization and infection of uropathogenic Escherichia coli is adherence to uroepithelium. Over 80% of all urinary tract infections are caused by E. coli. Uropathogenic E. coli express several adherence factors including type 1 and P fimbriae, which mediate attachment to the uroepithelium through specific binding to different glycoconjugate receptors. We showed that P and type 1 fimbriae are not the sole adhesins on uropathogenic E. coli and sialic acid also mediates nonspecific bacterial adherence of uropathogenic E. coli and urinary bladder epithelium.
authors.affiliation: Division of Infectious Diseases and Clinical Microbiology, Department of Medicine, School of Medicine, Adnan Menderes University, 09100 Aydin, Turkey. serhansakarya@yahoo.com
authors.forename: Serhan
authors.initials: S
authors.lastname: Sakarya
authors.forename: Gunay Tuncer
authors.initials: GT
authors.lastname: Ertem
authors.forename: Serkan
authors.initials: S
authors.lastname: Oncu
authors.forename: Izzet
authors.initials: I
authors.lastname: Kocak
authors.forename: Nural
authors.initials: N
authors.lastname: Erol
authors.forename: Selcan
authors.initials: S
authors.lastname: Oncu
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects / Q000502:physiology*; D002460:Cell Line; D004848:Epithelium / Q000382:microbiology; D004926:Escherichia coli / Q000472:pathogenicity* / Q000502:physiology*; D004927:Escherichia coli Infections / Q000209:etiology; D010861:Fimbriae, Bacterial / Q000502:physiology; D006384:Hemagglutination; D051379:Mice; D019158:N-Acetylneuraminic Acid / Q000502:physiology; D009439:Neuraminidase / Q000494:pharmacology; D001743:Urinary Bladder / Q000382:microbiology*; D014552:Urinary Tract Infections / Q000209:etiology; D014774:Virulence / Q000502:physiology
chemical_list: D009439:Neuraminidase; D019158:N-Acetylneuraminic Acid