title: The use of triisopropylsilyl-oxymethyl (TOM) in the synthesis of anti-telomerase 2-5A antisense compound RBI 011.
abstract: The 2-5A antisense compound RBI 011 targeting telomerase RNA was synthesized using the triisopropylsilyl-oxymethyl (TOM) group for the 3'-hydroxyl protection of 2',5'-linked RNA.
authors.affiliation: Ridgeway Biosystems Inc., Cleveland, Ohio, USA.
authors.forename: Hagen
authors.initials: H
authors.lastname: Cramer
authors.forename: Rachele
authors.initials: R
authors.lastname: Rhea
authors.forename: Jim
authors.initials: J
authors.lastname: Okicki
authors.forename: Karen
authors.initials: K
authors.lastname: Yirava
authors.forename: Robert
authors.initials: R
authors.lastname: Silverman
mesh_terms: D015088:2',5'-Oligoadenylate Synthetase / Q000037:antagonists & inhibitors; D002678:Chimera; D004247:DNA / Q000737:chemistry; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides / Q000138:chemical synthesis*; D010766:Phosphorylation; D016372:RNA, Antisense / Q000138:chemical synthesis*; D012091:Repetitive Sequences, Nucleic Acid; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000235:genetics*
chemical_list: D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; C479443:RBI 011; D016372:RNA, Antisense; D004247:DNA; D019098:Telomerase; D015088:2',5'-Oligoadenylate Synthetase