Clethramycin, a new inhibitor of pollen tube growth with antifungal activity from Streptomyces hygroscopicus TP-A0623. II. Physico-chemical properties and structure determination.
Clethramycin is a novel linear polyene polyketide produced by a plant-associated actinomycete Streptomyces hygroscopicus TP-A0623. It possesses a guanidino and carboxyl residue at each end and an O-sulfate group and a hexaene moiety in the molecule, and its molecular formula is C63H99N3O18S. The structure was determined by analyzing 2D-NMR and FAB-MS data, using 13C-enriched compounds. Clethramycin is structurally similar to linearmycin, an inhibitor of spheroplast regeneration in Candida albicans. Clethramycin shows potent antifungal and pollen tube growth inhibitory activity.
Igarashi
Yasuhiro
Y
Biotechnology Research Center, Toyama Prefectural University, 5180, Kurokawa, Kosugi, Toyama 939-0398, Japan. yas@pu-toyama.ac.jp
Iwashita
Takashi
T
Fujita
Tsuyoshi
T
Naoki
Hideo
H
Yamakawa
Takashi
T
Yoshida
Ryuji
R
Furuma
Tamotsu
T
D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000494:pharmacology; D035264:Flowers / Q000187:drug effects / Q000254:growth & development; D013463:Sulfuric Acid Esters / Q000737:chemistry / Q000494:pharmacology
D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; D013463:Sulfuric Acid Esters; C478490:clethramycin