title: Discrepancy between [18F]fluorodeoxyglucose and 11C-methionine positron emission tomography findings in Sturge-Weber syndrome--case report.
abstract: Cerebral blood flow and metabolism were evaluated in an adult with symptomatic intractable epilepsy and Sturge-Weber syndrome (SWS) manifesting as angiomas in the left cerebral hemisphere. 99mTc-ethylcysteinate dimer single photon emission computed tomography detected reduced blood flow in the entire left cerebral hemisphere, and [18F]fluorodeoxyglucose positron emission tomography (PET) showed decreased glucose metabolism in the left cerebral hemisphere. These findings indicated hypofunction of the left cerebral hemisphere, which caused the right hemiparesis. 11C-methionine (11C-Met) PET revealed high 11C-Met accumulation in the angiomas in the left cerebral hemisphere. Immunostaining for glial fibrillary acidic protein showed positive reaction in the lesions. Gliosis is a likely mechanism for the 11C-Met accumulation, which is possibly associated with progressive calcification in the angiomas and retarded growth of patients with SWS occurring over many years.
authors.affiliation: Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Ichinose
authors.forename: Naohiro
authors.initials: N
authors.lastname: Tsuyuguchi
authors.forename: Michiharu
authors.initials: M
authors.lastname: Morino
authors.forename: Ichiro
authors.initials: I
authors.lastname: Sunada
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohata
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Takami
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Shimonishi
authors.forename: Joji
authors.initials: J
authors.lastname: Kawabe
authors.forename: Susumu
authors.initials: S
authors.lastname: Shiomi
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Hara
mesh_terms: D000328:Adult; D002250:Carbon Radioisotopes; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008715:Methionine; D019275:Radiopharmaceuticals; D013341:Sturge-Weber Syndrome / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed
chemical_list: D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D008715:Methionine