title: Tumor oximetry: comparison of 19F MR EPI and electrodes.
abstract: We recently described a novel approach to measuring regional tumor oxygen tension. This approach is based on 19F pulse burst saturation recovery NMR echo planar imaging relaxometry of hexafluorobenzene or "FREDOM" (Fluorocarbon Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping). We have now compared oxygen tension measurements using FREDOM with a traditional polarographic method (the Eppendorf Histograph) in a group of size matched Dunning prostate rat tumors R3327-AT1. We also compare MR and electrode approaches to monitoring dynamic changes with respect to interventions and demonstrate extension of the MR technique to rat breast tumors.
authors.affiliation: U.T. Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Ralph P
authors.initials: RP
authors.lastname: Mason
authors.forename: Sandeep
authors.initials: S
authors.lastname: Hunjan
authors.forename: Anca
authors.initials: A
authors.lastname: Constantinescu
authors.forename: Yulin
authors.initials: Y
authors.lastname: Song
authors.forename: Dawen
authors.initials: D
authors.lastname: Zhao
authors.forename: Eric W
authors.initials: EW
authors.lastname: Hahn
authors.forename: Peter P
authors.initials: PP
authors.lastname: Antich
authors.forename: Peter
authors.initials: P
authors.lastname: Peschke
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism*; D000818:Animals; D004566:Electrodes; D005461:Fluorine; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010092:Oximetry / Q000295:instrumentation / Q000379:methods*; D011471:Prostatic Neoplasms / Q000378:metabolism*; D051381:Rats
chemical_list: D005461:Fluorine