Identification of potent and novel small-molecule inhibitors of caspase-3.
The design and synthesis of a series of novel, reversible, small molecule inhibitors of caspase-3 are described.
Allen
Darin A
DA
Sunesis Pharmaceuticals, Inc., 341 Oyster Point Boulevard, South San Francisco, CA 94080, USA. dallen@sunesis.com
Pham
Phuongly
P
Choong
Ingrid C
IC
Fahr
Bruce
B
Burdett
Matthew T
MT
Lew
Willard
W
DeLano
Warren L
WL
Gordon
Eric M
EM
Lam
Joni W
JW
O'Brien
Tom
T
Lee
Dennis
D
D000447:Aldehydes / Q000737:chemistry; D053148:Caspase 3; D061945:Caspase Inhibitors; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007659:Ketones / Q000737:chemistry; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000447:Aldehydes; D061945:Caspase Inhibitors; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D007659:Ketones; D053148:Caspase 3