Hepatocellular carcinoma associated with precocious puberty and oral contraceptives. A case report.
A 36-year-old woman presented with sudden abdominal pain and vomiting. Computed tomography showed a tumour of the right hepatic lobe with possible signs of acute haemorrhage. Her medical history revealed precocious puberty when she was a 5-year-old and the use of oral contraceptives for 18 years. Bisegmentectomy was performed and histological examination revealed hepatocellular carcinoma. The role of male and female sex hormones in the development of hepatic tumours has been well documented but, to our knowledge, association with precocious puberty has not yet been described.
Mansvelt
B
B
Service de Chirurgie Digestive, Centre Hospitalier Jolimont-Lobbes, B-7100 Haine Saint-Paul, Belgique. baudouin.mansvelt@village.uunet.be
Etienne
P Y
PY
Bertrand
C
C
Henrion
J
J
Gerard
R
R
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D004967:Estrogens / Q000009:adverse effects*; D004997:Ethinyl Estradiol / Q000009:adverse effects*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000209:etiology* / Q000601:surgery; D011629:Puberty, Precocious / Q000150:complications*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D003278:Contraceptives, Oral, Hormonal; D004967:Estrogens; D004997:Ethinyl Estradiol