title: The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinomas and EBV-negative ones.
abstract: The relationship between the degree of lymphocytic infiltration into the tumor and the prognosis has not been completely evaluated between Epstein-Barr virus (EBV)-positive and -negative gastric carcinoma (GC). Although the average numbers and the grades of the infiltrating CD8+T cells, natural killer cells, dendritic cells, Ki67-positive cells were significantly greater in EBV-positive GCs than in -negative GCs, there was no significant survival improvement in EBV-positive group. These findings suggest that the infiltration of lymphocytes in the EBV-positive GC does not necessarily meant better prognosis and that the EBV status is not a significant prognostic factor in the patients with gastric cancer.
authors.affiliation: Department of Surgical Oncology and Digestive Surgery, Kagoshima University, 8-35-1 Sakuragaoka, 890-8520, Kagoshima, Japan. ykijima@m3.kufm.kagoshima-u.ac.jp
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kijima
authors.forename: Sumiya
authors.initials: S
authors.lastname: Ishigami
authors.forename: Shuichi
authors.initials: S
authors.lastname: Hokita
authors.forename: Chihaya
authors.initials: C
authors.lastname: Koriyama
authors.forename: Suminori
authors.initials: S
authors.lastname: Akiba
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Eizuru
authors.forename: Takashi
authors.initials: T
authors.lastname: Aikou
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D016246:Lymphocytes, Tumor-Infiltrating; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012367:RNA, Viral / Q000032:analysis; D013274:Stomach Neoplasms / Q000821:virology*
chemical_list: C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral