[Association between polymorphisms in the gene coding for glutathione S-transferase P1 and chronic obstructive pulmonary disease].
OBJECTIVE
To investigate the association between polymorphisms in the gene coding for glutathione S-transferase P1 (GSTP1) and susceptibility to chronic obstructive pulmonary disease (COPD) in a Chinese population.


METHODS
This was a pilot study of the molecular epidemiology in patients with COPD. The research design was a case-control study. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to genotype GSTP1 polymorphisms in exon 5 in 100 COPD patients and 100 age and sex matched healthy controls. Logistic regression analysis method was used to calculate the odds ratio (OR) and the 95% confidence interval (CI).


RESULTS
There was no significant difference in GSTP1 polymorphisms adjusted by age, sex, body mass index and smoking between COPD patients and controls.


CONCLUSIONS
The gene polymorphism for GSTP1 was not associated with susceptibility to COPD in the Chinese population.
Xiao
Dan
D
Beijing Chaoyang Hospital-Beijing Institute of Respiratory Medicine, Capital University of Medical Science, Beijing 100020, China.
Wang
Chen
C
Du
Min-jie
MJ
Pang
Bao-sen
BS
Zhang
Hong-yu
HY
Xiao
Bai
B
Liu
Jing-zhong
JZ
Weng
Xin-zhi
XZ
Su
Li
L
Christiani
David C
DC
D000368:Aged; D002874:Chromosome Mapping; D005260:Female; D005838:Genotype; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*
D007527:Isoenzymes; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase