title: Halophilols A and B, two new stilbenes from Iris halophila.
abstract: A new monomeric stilbene, halophilol A (1), and a new tetrastilbene, halophilol B (2), along with three known oligostilbenes were isolated from the seeds of Iris halophila. Their structures were established on the basis of the spectral data. The oligostilbene skeleton is encountered for the first time in the Iridaceae family. Bioactivity tests showed that 1 had moderate cytotoxicity against KB and HMEC cell lines (IC50 = 17.28 microM, 22.47 microM respectively), while 2 was inactive.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, PR China.
authors.forename: Yong-Qiang
authors.initials: YQ
authors.lastname: Wang
authors.forename: Jun-Jie
authors.initials: JJ
authors.lastname: Tan
authors.forename: Chang-Heng
authors.initials: CH
authors.lastname: Tan
authors.forename: Shan-Hao
authors.initials: SH
authors.lastname: Jiang
authors.forename: Da-Yuan
authors.initials: DY
authors.lastname: Zhu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D031323:Iris Plant; D008517:Phytotherapy; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013267:Stilbenes