The interaction of MS and pregnancy: a critical review.
Previous research on the effects of pregnancy on multiple sclerosis (MS) is somewhat flawed, and well-controlled, well-designed studies are needed to validate trial findings. In general, pregnancy appears to have a protective effect on MS course, with fewer, less severe relapses, especially in the third trimester. The exacerbation rate is increased in the first 3 months after delivery, but the overall relapse rate is no different to that observed in non-pregnant MS patients. A woman's past history of relapses may be the best indicator of clinical course during and immediately after pregnancy. Pregnancy does not appear to affect the long-term course of MS.
Dwosh
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Department of Medical Genetics, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, V6T 2B5 Canada.
Guimond
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Duquette
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Sadovnick
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AD
D004967:Estrogens / Q000378:metabolism*; D005260:Female; D006801:Humans; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications
D004967:Estrogens