title: Transdetermination in Drosophila imaginal discs: a model for understanding pluripotency and selector gene maintenance.
abstract: Drosophila imaginal disc cells have the ability to undergo transdetermination, a process whereby determined disc cells change fate to that of another disc identity. For example, leg disc cells can transdetermine to develop as wing cells. Such events can occur after mechanical disc fragmentation and subsequent regeneration. A subset of transdetermination events can be induced in situ by misexpression of the signaling gene wingless. Both fragmentation and wingless induce transdetermination by altering the expression of selector genes, which drive disc-specific developmental programs. An important future goal is to address how signaling pathways interact with chromatin structure to regulate and maintain the proper expression of selector genes.
authors.affiliation: Institute of Neuroscience, 1254 University of Oregon, Eugene, Oregon 97403-1254, USA. maves@uoneuro.uoregon.edu
authors.forename: Lisa
authors.initials: L
authors.lastname: Maves
authors.forename: Gerold
authors.initials: G
authors.lastname: Schubiger
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002843:Chromatin / Q000502:physiology; D042002:Chromatin Assembly and Disassembly / Q000502:physiology; D004330:Drosophila / Q000235:genetics / Q000254:growth & development* / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D051155:Wnt1 Protein
chemical_list: D002843:Chromatin; D029721:Drosophila Proteins; D011518:Proto-Oncogene Proteins; D051155:Wnt1 Protein; C074622:wg protein, Drosophila