title: Prognostic factors in the management outcome of carcinoma of the larynx in Lagos.
abstract: This is a retrospective analysis on the prognostic factors in the management outcome of clinically and histologically diagnosed carcinoma of larynx seen in Lagos University Teaching Hospital between 1996-1999. Various prognostic factors have been documented as determinants on the probable outcome of carcinoma of the larynx, such as duration of symptoms, smoking, medical status of the patient, degree of differentiation, size and site of tumour and presence of cervical lymph node. Thirty-six patients between 1996-1999 were reviewed, with a male to female ratio of 11:1, and peak age group of occurrence in 50-59 years, majority (86.12%) of which were non-smokers who presented in varied degrees of airway obstruction necessitating pre-treatment tracheostomy in 70% of the patients with more than 50% presenting within 3-6 months of onset of initial symptom. The tumours were staged clinically and histology revealed well differentiated T3 glottic tumour without any clinically palpable neck node in more than 50% of the patients which should predict a better outcome. But the interplay of many prognostic variables like pre-treatment tracheostomy and its attendant complications, supposed biological aggressive tumour in a non-smoker, coupled with treatment biased by patients, high costs of treatment, logistics and poor follow up compliance, resulted in poor outcome of our management.
authors.affiliation: Otorhinolaryngology Unit, Department of Surgery, College of Medicine, University of Lagos, P.M.B. 12003, Lagos, Nigeria.
authors.forename: O A
authors.initials: OA
authors.lastname: Somefun
authors.forename: C C
authors.initials: CC
authors.lastname: Nwawolo
authors.forename: P A
authors.initials: PA
authors.lastname: Okeowo
authors.forename: S B
authors.initials: SB
authors.lastname: Alabi
authors.forename: F B
authors.initials: FB
authors.lastname: Abdul-Kareem
authors.forename: A A
authors.initials: AA
authors.lastname: Banjo
authors.forename: S O
authors.initials: SO
authors.lastname: Elesha
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome