[Effects of ulinastatin on interleukin-8 during one-lung ventilation in surgery].
OBJECTIVE
Ulinastatin is a kind of broad- spectrum hydrolase inhibitors purified from urine of healthy males.There was no data showing whether ulinastatin could affect alveolar inflammatory reactions.This study was designed to investigate the changes of pulmonary alveolar interleukin-8 during one lung ventilation (OLV) in surgery and the effects of ulinastatin on alveolar IL-8.


METHODS
Sixty patients,ASA II- III,who underwent lobectomy, were randomly divided into two groups [30 patients in each group,surgery group(II) and control group (I)].Patients in surgery group were treated with ulinastatin 5,000 u/kg preoperatively. Alveolar IL-8 was harvested by bronchoalveolar lavage at 0, 1, and 2 hours after one lung ventilation and at the end of surgery. The changes of concentration of IL-8 in bronchoalveolar lavage fluid were analyzed statistically.


RESULTS
(1)Alveolar interleukin 8 was significantly higher at 2 hours after OLV [(160.85+/-46.58)ng/L] than before OLV [(128.26+/-35.35)ng/L] in control group. The results indicated that OLV and/or the stimulation of surgery could induce the pulmonary inflammatory reaction. (2)The concentrations of alveolar IL-8 at 2 hours [(140.32+/-41.25)ng/L] after OLV and at the end of surgery [ (156.74+/-43.58) ng/L] were significantly lower in surgery group than those in control group [(160.85+/-46.58)ng/L and (172.41+/-52.60)ng/L] respectively(P< 0.05).


CONCLUSIONS
Ulinastatin could alleviate the pulmonary alveolar inflammatory reactions in OLV.
Li
Wei
W
Department of Anesthesiology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, PR China. liweigzcn@263.net
Wang
Jian
J
Jiang
Yan-Bo
YB
Xu
Mei-Xi
MX
D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D005260:Female; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D016209:Interleukin-8 / Q000032:analysis*; D008175:Lung Neoplasms / Q000276:immunology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial / Q000379:methods*
D006023:Glycoproteins; D016209:Interleukin-8; C028665:urinastatin