title: Therapeutic efficiency of dimephosphone and xydiphone in experimental pulse therapy with prednisolone.
abstract: Experiments on rats showed that pulse therapy with prednisolone (100 mg/kg intraperitoneally for 3 days) stimulated urinary excretion of hydroxyproline, increased the content of inorganic phosphorus, promoted the increase in the content of dienic conjugates and catalase activity, and decreased serum levels of MDA and ceruloplasmin. Ten-day treatment with dimephosphone (208 mg/kg) or xydiphone (45 mg/kg) after pulse therapy with prednisolone normalized urinary excretion of hydroxyproline and reduced the levels of dienic conjugates. Dimephosphone did not change, while xydiphone normalized the level of MDA decreased by prednisolone.
authors.affiliation: Central Research Laboratory and Department of Pharmacology, Kazan State Medical University.
authors.forename: I Kh
authors.initials: IKh
authors.lastname: Valeeva
authors.forename: L E
authors.initials: LE
authors.lastname: Ziganshina
authors.forename: Z A
authors.initials: ZA
authors.lastname: Burnashova
authors.forename: A U
authors.initials: AU
authors.lastname: Ziganshin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D012968:Etidronic Acid / Q000494:pharmacology*; D005260:Female; D005938:Glucocorticoids / Q000378:metabolism / Q000494:pharmacology; D006909:Hydroxyproline / Q000378:metabolism / Q000652:urine; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010710:Phosphates; D010758:Phosphorus / Q000097:blood; D011239:Prednisolone / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D035703:Therapies, Investigational; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D009943:Organophosphorus Compounds; D010710:Phosphates; C049638:dimephosphon; D010758:Phosphorus; D008315:Malondialdehyde; D011239:Prednisolone; D002374:Catalase; D002570:Ceruloplasmin; D012968:Etidronic Acid; D006909:Hydroxyproline; D002118:Calcium