Perspectives for the industrial enzymatic production of glycosides.
Glycosides are of commercial interest for industry in general and specifically for the pharmaceutical and food industry. Currently chemical preparation of glycosides will not meet EC food regulations, and therefore chemical preparation of glycosides is not applicable in the food industry. Thus, enzyme-catalyzed reactions are a good alternative. However, until now the low yields obtained by enzymatic methods prevent the production of glycosides on a commercial scale. Therefore, high yields should be established by a combination of optimum reaction conditions and continuous removal of the product. Unfortunately, a bioreactor for the commercial scale production of glycosides is not available. The aim of this article is to discuss the literature with respect to enzymatic production of glycosides and the design of an industrially viable bioreactor system.
de Roode
B Mattheus
BM
Department of Agrotechnology and Food Sciences, Food and Bioprocess Engineering Group, Wageningen University, Bomenweg 2, 6703 HD Wageningen, The Netherlands.
Franssen
Maurice C R
MC
van der Padt
Albert
A
Boom
Remko M
RM
D019149:Bioreactors; D002241:Carbohydrates / Q000737:chemistry*; D002617:Chemical Industry / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D004798:Enzymes / Q000737:chemistry* / Q000145:classification; D004800:Enzymes, Immobilized / Q000737:chemistry; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry; D006031:Glycosylation
D002241:Carbohydrates; D004798:Enzymes; D004800:Enzymes, Immobilized; D006027:Glycosides