title: Changes in DWI and MRS associated with white matter hyperintensities in elderly subjects.
abstract: OBJECTIVE
  To assess normal-appearing white matter (NAWM) characteristics by magnetic resonance spectroscopy (MRS) and diffusion-weighted imaging (DWI) in elderly subjects.
  
  
  METHODS
  The authors studied 60 volunteers (mean age 72.6 years; SD 4.7; range 64 to 84 years) without signs of neurologic illness. They used DWI and spectroscopic imaging to investigate whether there were changes in the NAWM that related to the presence of white matter hyperintensities (WMH).
  
  
  RESULTS
  The authors found a correlation (p < 0.001) between the apparent diffusion coefficient in the NAWM and the total volume of WMH. The metabolite ratios N-acetylaspartate/creatine and N-acetylaspartate/choline of the NAWM also correlated significantly with total WMH volume. These correlations were independent of age.
  
  
  CONCLUSIONS
  Damage associated with WMH is detectable in NAWM.
authors.affiliation: Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK. m.j.firbank@ncl.ac.uk
authors.forename: M J
authors.initials: MJ
authors.lastname: Firbank
authors.forename: T
authors.initials: T
authors.lastname: Minett
authors.forename: J T
authors.initials: JT
authors.lastname: O'Brien
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000378:metabolism*; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D003430:Cross-Sectional Studies; D004058:Diffusion; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D014867:Water / Q000378:metabolism
chemical_list: D014867:Water; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline