A big step in the study of small cell lung cancer.
A rationally designed, conditional p53 and Rb allele-based and lung-targeted mouse model of human small cell lung cancer (SCLC) provides the cancer research community with a valid and important new tool to use in translational research against this deadly disease.
Minna
John D
JD
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. john.minna@utsouthwestern.edu
Kurie
Jonathan M
JM
Jacks
Tyler
T
D000483:Alleles; D000818:Animals; D018288:Carcinoma, Small Cell / Q000235:genetics* / Q000473:pathology; D016161:Genes, Retinoblastoma / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D051379:Mice; D023421:Models, Animal; D009154:Mutation; D009362:Neoplasm Metastasis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D016159:Tumor Suppressor Protein p53