title: New ent-kaurene-type diterpenoids possessing cytotoxicity from the New Zealand liverwort Jungermannia species.
abstract: Two new ent-kaurene-type and a new rearranged ent-kaurene-type diterpenoids possessing cytotoxicity against a human leukemia cell line have been isolated from the New Zealand liverwort Jungermannia species, together with previously known ent-kaurene-type diterpenoids. Their structures were established based on extensive NMR techniques.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Japan.
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Nagashima
authors.forename: Wakana
authors.initials: W
authors.lastname: Kasai
authors.forename: Masuo
authors.initials: M
authors.lastname: Kondoh
authors.forename: Makiko
authors.initials: M
authors.lastname: Fujii
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Watanabe
authors.forename: John Edward
authors.initials: JE
authors.lastname: Braggins
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D035926:Hepatophyta; D006801:Humans; D009520:New Zealand; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity
chemical_list: D004224:Diterpenes; D045786:Diterpenes, Kaurane; D010936:Plant Extracts