Healthy ranges of serum alanine aminotransferase levels in Iranian blood donors.
OBJECTIVE
The healthy ranges for serum alanine aminotransferase (ALT) levels are less well studied. The aim of this study was to define the upper limit of normal (ULN) for serum ALT levels, and to assess factors associated with serum ALT activity in apparently healthy blood donors.


METHODS
A total of 1,939 blood donors were included. ALT measurements were performed for all cases using the same laboratory method. Healthy ranges for ALT levels were computed from the population at the lowest risk for liver disease. Univariate and multivariate analyses were performed to evaluate associations between clinical factors and ALT levels.


RESULTS
Serum ALT activity was independently associated with body mass index (BMI) and male gender, but not associated with age. Association of ALT with BMI was more prominent in males than in females. Upper limit of normal for non-overweight women (BMI of less than 25) was 34 U/L, and for non-overweight men was 40 U/L.


CONCLUSIONS
Serum ALT is strongly associated with sex and BMI. The normal range of ALT should be defined for male and female separately.
Mohamadnejad
Mehdi
M
Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Pourshams
Akram
A
Malekzadeh
Reza
R
Mohamadkhani
Ashraf
A
Rajabiani
Afsaneh
A
Asgari
Ali Ali
AA
Alimohamadi
Seyed Meysam
SM
Razjooyan
Hadi
H
Mamar-Abadi
Mansooreh
M
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000410:Alanine Transaminase / Q000032:analysis / Q000097:blood*; D001782:Blood Donors; D015992:Body Mass Index; D002624:Chemistry, Clinical / Q000592:standards* / Q000706:statistics & numerical data; D002648:Child; D005260:Female; D006801:Humans; D007492:Iran; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D017678:Sex Distribution
D000410:Alanine Transaminase