title: Diversification and evolution of L-myo-inositol 1-phosphate synthase.
abstract: L-myo-Inositol 1-phosphate synthase (MIPS, EC 5.5.1.4), the key enzyme in the inositol and phosphoinositide biosynthetic pathway, is present throughout evolutionarily diverse organisms and is considered an ancient protein/gene. Analysis by multiple sequence alignment, phylogenetic tree generation and comparison of newly determined crystal structures provides new insight into the origin and evolutionary relationships among the various MIPS proteins/genes. The evolution of the MIPS protein/gene among the prokaryotes seems more diverse and complex than amongst the eukaryotes. However, conservation of a 'core catalytic structure' among the MIPS proteins implies an essential function of the enzyme in cellular metabolism throughout the biological kingdom.
authors.affiliation: Plant Molecular and Cellular Genetics, Bose Institute (Centenary Building), Kolkata, India. lahiri@bic.boseinst.ernet.in
authors.forename: Arun Lahiri
authors.initials: AL
authors.lastname: Majumder
authors.forename: Anirban
authors.initials: A
authors.lastname: Chatterjee
authors.forename: Krishnarup
authors.initials: K
authors.lastname: Ghosh Dastidar
authors.forename: Manoj
authors.initials: M
authors.lastname: Majee
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D018360:Crystallography, X-Ray; D019143:Evolution, Molecular; D006801:Humans; D008969:Molecular Sequence Data; D007296:Myo-Inositol-1-Phosphate Synthase / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D010802:Phylogeny; D013329:Structure-Activity Relationship
chemical_list: D007296:Myo-Inositol-1-Phosphate Synthase