title: Methylated hexitol nucleic acids, towards congeners with improved antisense potential.
abstract: In an effort to further improve the hybridisation potential of anhydro-hexitol nucleoside analogues, the 1'-methoxyl and 3'-methoxyl substituents were introduced and evaluated for their antisense potential. In view of the selectivity of pairing with RNA, especially the introduction of a 3'-O-alkyl moiety deserves further study.
authors.affiliation: Laboratory for Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium. arthur.vanaerschot@rega.kuleuven.ac.be
authors.forename: A
authors.initials: A
authors.lastname: Van Aerschot
authors.forename: A
authors.initials: A
authors.lastname: Marchand
authors.forename: G
authors.initials: G
authors.lastname: Schepers
authors.forename: W
authors.initials: W
authors.lastname: Van den Eynde
authors.forename: J
authors.initials: J
authors.lastname: Rozenski
authors.forename: R
authors.initials: R
authors.lastname: Busson
authors.forename: P
authors.initials: P
authors.lastname: Herdewijn
mesh_terms: D000438:Alcohols; D000478:Alkylation; D008745:Methylation; D009696:Nucleic Acids / Q000138:chemical synthesis*; D009705:Nucleosides / Q000138:chemical synthesis
chemical_list: D000438:Alcohols; D009696:Nucleic Acids; D009705:Nucleosides