title: Tuberculosis in a child presenting as asymptomatic oropharyngeal and laryngeal lesions.
abstract: We describe an 11-year-old boy who had several, asymptomatic, erythematous papules in the oropharynx and larynx with recent onset, two cervical lymphadenopathies, and a painless, erythematous plaque on the right wrist with a 2.5-year history of slow growth. Histologic examination of the mucocutaneous lesions revealed a submucous infiltrate of lymphocytes and Langhans giant cells in the papules and granulomatous dermatitis in the plaque. The cervical lymph node was biopsied and on the surgical scar, an erythematous, nodular lesion developed. A biopsy specimen of this lesion showed tuberculoid granulomas with prominent caseation necrosis, and culture was positive for Mycobacterium tuberculosis. The Mantoux test was strongly positive with a vesicular response. A diagnosis of mucocutaneous lupus vulgaris and scrofuloderma secondary to cervical tuberculous lymphadenitis was made. Two months after initiation of antituberculosis therapy there was a complete resolution of mucous lesions and healing with atrophic scars on the neck and wrist. This is a rare presentation in the literature and reminds clinicians that tuberculosis should be kept in mind in the differential diagnosis of oral cavity lesions.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Hospital S. João, Porto, Portugal. smagina@mail.med.up.pt
authors.forename: S
authors.initials: S
authors.lastname: Magina
authors.forename: C
authors.initials: C
authors.lastname: Lisboa
authors.forename: C
authors.initials: C
authors.lastname: Resende
authors.forename: F
authors.initials: F
authors.lastname: Azevedo
authors.forename: F
authors.initials: F
authors.lastname: Amado
authors.forename: V
authors.initials: V
authors.lastname: Cardoso
authors.forename: F
authors.initials: F
authors.lastname: Almeida
authors.forename: J
authors.initials: J
authors.lastname: Mesquita-Guimarães
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D002648:Child; D003937:Diagnosis, Differential; D006801:Humans; D007830:Larynx; D008177:Lupus Vulgaris / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D009960:Oropharynx; D014382:Tuberculosis, Cutaneous / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents