title: COMET: a proposed mechanism of action to explain the results and concerns about dose.
authors.forename: Steven G
authors.initials: SG
authors.lastname: Coca
authors.forename: Gregory K
authors.initials: GK
authors.lastname: Buller
mesh_terms: D000251:Adenosine Triphosphatases / Q000187:drug effects; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D002227:Carbazoles / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D000077261:Carvedilol; D027682:Cation Transport Proteins; D002986:Clinical Trials as Topic; D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced* / Q000150:complications; D008790:Metoprolol / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D011188:Potassium / Q000097:blood; D011412:Propanolamines / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D027682:Cation Transport Proteins; D011412:Propanolamines; D000077261:Carvedilol; D000251:Adenosine Triphosphatases; C022761:potassium transporting ATPase; D008790:Metoprolol; D011188:Potassium