title: Duration of untreated psychosis and outcome of schizophrenia: delay in intensive psychosocial treatment versus delay in treatment with antipsychotic medication.
abstract: Duration of untreated psychosis (DUP), defined as delay in treatment with antipsychotic medication, was found to be associated with an unfavorable course of schizophrenia. Delay in intensive psychosocial treatment (DIPT) may also be related to outcome. We examined the relationship of DUP and DIPT with several outcome domains 6 years after onset in a cohort of 88 consecutively admitted patients with early-onset schizophrenia and related disorders. Patients and their parents completed an inventory concerning DUP, DIPT, and various aspects of outcome. Psychotic relapse during the first year after hospitalization was assessed with a chart review. Both DUP and DIPT were found to be associated with negative symptoms at outcome; mode of onset was not. DUP was associated with mild psychotic relapse. DIPT was associated with months of rehospitalization. There was no relation between DUP or DIPT and other aspects of outcome. When we controlled for age at onset, gender, and duration of treated first psychotic episode, only DIPT was associated with negative symptoms at outcome. DIPT may be a more important predictor of negative symptoms at outcome than is delay in starting antipsychotic medication alone.
authors.affiliation: Adolescent Clinic, Academic Medical Center, University of Amsterdam, Department of Psychiatry, Amsterdam, The Netherlands. l.dehaan@amc.uva.nl
authors.forename: Lieuwe
authors.initials: L
authors.lastname: de Haan
authors.forename: Don H
authors.initials: DH
authors.lastname: Linszen
authors.forename: Marie E
authors.initials: ME
authors.lastname: Lenior
authors.forename: Evelyne Doderlein
authors.initials: ED
authors.lastname: de Win
authors.forename: Rob
authors.initials: R
authors.lastname: Gorsira
mesh_terms: D000328:Adult; D017668:Age of Onset; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D015331:Cohort Studies; D004334:Drug Administration Schedule; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D012008:Recurrence; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D012737:Sex Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents