Epinastine inhibits eosinophil chemotaxis and adhesion molecules in atopic dermatitis.
OBJECTIVE
To investigate the effects of epinastine on eosinophil chemotaxis and changes in eosinophil adhesion molecules induced by epinastine and three other antiallergic agents, using eosinophils of atopic dermatitis (AD) patients.


RESULTS
Epinastine reduced eosinophil chemotaxis toward eotaxin when the eosinophils had been prestimulated with interleukin (IL)-5, but given alone it did not alter eosinophil chemotaxis toward IL-5. CD11b expression was inhibited when peripheral blood was prestimulated with IL-5, but eosinophil adhesion molecule expression was not altered.


CONCLUSIONS
Epinastine suppresses allergic inflammation not only through its strong antihistamine and antimediator effects, but also by inhibiting eosinophilic chemotaxis and the expression of adhesion molecules involved in chemotaxis, especially CD11b.
Matsukura
M
M
Department of Dermatology, Kinki University School of Medicine, Osaka, Japan. matsukura@syd.odn.ne.jp
Yajima
A
A
Yamazaki
F
F
Yudate
T
T
Yamada
H
H
Tezuka
T
T
D000328:Adult; D015703:Antigens, CD / Q000096:biosynthesis; D001562:Benzimidazoles / Q000494:pharmacology; D039481:CD11b Antigen / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000037:antagonists & inhibitors*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003876:Dermatitis, Atopic / Q000473:pathology*; D003984:Dibenzazepines / Q000494:pharmacology*; D004804:Eosinophils / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D015848:Interleukin-5 / Q000494:pharmacology; D007665:Ketotifen / Q000494:pharmacology; D008297:Male; D010793:Phthalazines / Q000494:pharmacology
D015703:Antigens, CD; D001562:Benzimidazoles; D039481:CD11b Antigen; D015815:Cell Adhesion Molecules; D003984:Dibenzazepines; D006634:Histamine H1 Antagonists; D007093:Imidazoles; D015848:Interleukin-5; D010793:Phthalazines; C043345:emedastine; C053090:epinastine; D007665:Ketotifen; C020976:azelastine