title: Impact of interstitial lung disease on surgical morbidity and mortality for lung cancer: analyses of short-term and long-term outcomes.
abstract: BACKGROUND
  This study investigated postoperative morbidity, mortality, and the long-term survival for patients with lung cancer who have interstitial lung diseases.
  
  
  METHODS
  A retrospective chart review of 931 patients with lung cancer who underwent pulmonary resection at Chiba University Hospital between 1990 and 2000 was undertaken. Interstitial lung disease was defined by medical history, physical examination, and abnormalities compatible with bilateral lung fibrosis on chest computed tomography or high-resolution computed tomography (36 patients: 3.9%, interstitial lung diseases group). The remaining 895 patients (96.1%) were categorized as non-interstitial lung disease group.
  
  
  RESULTS
  The incidence of postoperative pneumonia and acute or exacerbation of interstitial pneumonia was higher in the interstitial lung disease group (all P <.05). Thirty-day mortality was statistically equivalent between the interstitial lung disease and the non-interstitial lung disease groups (P =.30). The 5-year overall survivals were 62.5% (non-interstitial lung disease) and 35.6% (interstitial lung disease). Respiratory failure was the second main cause of death after the recurrence of primary cancer in the interstitial lung disease group. The risk factors for long-term mortality were interstitial lung diseases, advanced pathologic stage, male sex, high age, and positive smoking history (all P <.05).
  
  
  CONCLUSIONS
  Interstitial lung disease was a risk factor for developing postoperative morbidity and mortality and poor long-term survival due to the occurrence of respiratory failure.
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Chiyo
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sekine
authors.forename: Takekazu
authors.initials: T
authors.lastname: Iwata
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tatsumi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yasufuku
authors.forename: Akira
authors.initials: A
authors.lastname: Iyoda
authors.forename: Mizuto
authors.initials: M
authors.lastname: Otsuji
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Yoshida
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Shibuya
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Iizasa
authors.forename: Yukio
authors.initials: Y
authors.lastname: Saitoh
authors.forename: Takehiko
authors.initials: T
authors.lastname: Fujisawa
mesh_terms: D000367:Age Factors; D000368:Aged; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000209:etiology; D008175:Lung Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011014:Pneumonia / Q000209:etiology; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects