title: Color Doppler sonography with contrast in the differentiation of ovarian tumors.
abstract: The objective of this study was to differentiate benign ovarian tumors from malignant ones before surgery using color and pulsed Doppler sonography, and to compare results obtained before and after use of contrast medium, thereby verifying whether contrast results in an improvement in the diagnostic sensitivity.
  
  
  METHODS
  Sixty two women (mean age 49.9 years) with ovarian tumors were studied, 45 with benign and 17 with malignant tumors. All women underwent a transvaginal color Doppler ultrasonographic exam. A study of the arterial vascular flow was made in all tumor areas, as well as an impedance evaluation of arterial vascular flow using the resistance index.
  
  
  RESULTS
  Localization of the vessels in the tumor revealed a greater proportion of malignant tumors with detectable internal vascular flows (64%) than benign tumors with such flows (22%). There was a considerable overlap of these findings. The use of contrast identified a greater number of vessels with confirmation in the totality of tumors, but did not improve the Doppler capacity in tumoral differentiation. Malignant tumors presented lower values of resistance index than the benign ones, whether or not contrast was used. The cutoff value for resistance index that better maximized the Doppler sensitivity and specificity was 0.55. Through this value, an increase of the sensitivity after contrast use was obtained, varying from 47% to 82%, while specificity remained statistically unchanged.
  
  
  CONCLUSIONS
  Although the injection of a microbubble agent improved the sensitivity of the method detecting vascularization of tumors, a positive finding for vascularization by this method was not clinically useful in the differentiation of benign and malignant ovarian tumors.
authors.affiliation: Division of Gynecologic Oncology, Department of Gynecology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo, São Paulo/SP, Brazil.
authors.forename: Eduardo Cardoso
authors.initials: EC
authors.lastname: Blanco
authors.forename: Ayrton Roberto
authors.initials: AR
authors.lastname: Pastore
authors.forename: Angela Maggio da
authors.initials: AM
authors.lastname: Fonseca
authors.forename: Filomena Marino
authors.initials: FM
authors.lastname: Carvalho
authors.forename: Jesus Paula
authors.initials: JP
authors.lastname: Carvalho
authors.forename: José Aristodemo
authors.initials: JA
authors.lastname: Pinotti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000601:surgery; D012039:Regional Blood Flow; D012680:Sensitivity and Specificity; D018615:Ultrasonography, Doppler, Color / Q000379:methods*; D018617:Ultrasonography, Doppler, Pulsed / Q000379:methods
chemical_list: D003287:Contrast Media