Ginseng increases intestinal elimination of albendazole sulfoxide in the rat.
Herbal products show potential drug interactions, some of them with adverse effects. The main aim of this work was to study the effect of Panax ginseng on the intestinal elimination of the benzimidazole derivative albendazole sulfoxide (ABZSO). An upper small intestine segment was isolated and perfused in situ with saline, while ABZSO solution (10 mg/kg i.v.) was administered intravenously. Blood samples and intestinal secretion were collected over 60 min and analysed by HPLC. The intestinal clearance of ABZSO was 0.106+/-0.010 ml/min. Systemic co-administration of ginseng (10 mg/kg i.v.) increased significantly (P<0.05) the clearance of ABZSO (0.132+/-0.005 ml/min). The increase in ABZSO elimination could be the result of the effect of ginseng on metabolic pathways. These results highlight the interactions between herbal products (sometimes dietary constituents) and drugs such as benzimidazoles, since ginseng modifies the luminal clearance of this anthelminthic drug and could potentially interfere with drugs that undergo the same intestinal processes.
Merino
Gracia
G
Department of Physiology, University of Leon, 24071, Leon, Spain.
Molina
Antonio J
AJ
García
José L
JL
Pulido
Mivis M
MM
Prieto
Julio G
JG
Alvarez
Ana I
AI
D015766:Albendazole / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics*; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D004359:Drug Therapy, Combination; D041743:Herb-Drug Interactions; D007275:Injections, Intravenous; D007408:Intestinal Absorption / Q000187:drug effects* / Q000502:physiology; D007583:Jejunum / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects / Q000502:physiology; D005894:Panax / Q000737:chemistry; D010477:Perfusion; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000871:Anthelmintics; D010936:Plant Extracts; D015766:Albendazole; C027186:albendazole sulfoxide