Antiviral activity of 2-amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one on poliovirus.
2-Amino-4,4alpha-dihydro-4alpha-7-dimethyl-3H-phenoxazine-3-one (Phx), which was produced by the reaction of bovine hemoglobin with 2-amino-5-methylphenol, inhibited the proliferation of poliovirus in Vero cells between 0.25 microg/ml and 2 microg/ml with maximal antiviral acitivity at 1 microg/ml. These results suggest that Phx may be useful to prevent the proliferation of poliovirus infection.
Iwata
Akiko
A
Division of Cellular and Gene Therapy Products, National Institute of Health Sciences, Tokyo 158-0098, Japan.
Yamaguchi
Teruhide
T
Sato
Kouei
K
Izumi
Ryutaro
R
Tomoda
Akio
A
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D010078:Oxazines / Q000494:pharmacology* / Q000633:toxicity; D017955:Poliovirus / Q000187:drug effects* / Q000254:growth & development; D014709:Vero Cells
C104202:2-amino-4,4alpha-dihydro-4alpha,7-dimethyl-3H-phenoxazine-3-one; D000998:Antiviral Agents; D010078:Oxazines