title: Primary congenital hypothyroidism, newborn thyroid function, and environmental perchlorate exposure among residents of a Southern California community.
abstract: The objectives of this study were to evaluate whether there were higher rates of primary congenital hypothyroidism (PCH) or elevated concentrations of thyroid-stimulating hormone (TSH) in a community where perchlorate was detected in groundwater wells. The adjusted PCH prevalence ratio and 95% confidence interval (CI) comparing the study community to San Bernardino and Riverside counties combined was 0.45 (95% CI=0.06-1.64). The odds ratios for elevated TSH concentration were 1.24 (95% CI=0.89-1.68) among all newborns screened and 0.69 (95% CI=0.27-1.45) for newborns whose age at screening was 18 hours or greater. Age of the newborn at time of screening was the most important predictor of the TSH level. These findings suggest that residence in a community with potential perchlorate exposure has not impacted PCH rates or newborn thyroid function.
authors.affiliation: Exponent, Inc, 149 Commonwealth Drive, Menlo Park, CA 94025, USA. mkelsh@exponent.com
authors.forename: Michael A
authors.initials: MA
authors.lastname: Kelsh
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Buffler
authors.forename: Jorge J
authors.initials: JJ
authors.lastname: Daaboul
authors.forename: George W
authors.initials: GW
authors.lastname: Rutherford
authors.forename: Edmund C
authors.initials: EC
authors.lastname: Lau
authors.forename: Julie C
authors.initials: JC
authors.lastname: Barnard
authors.forename: Alex K
authors.initials: AK
authors.lastname: Exuzides
authors.forename: Amy K
authors.initials: AK
authors.lastname: Madl
authors.forename: Lynn G
authors.initials: LG
authors.lastname: Palmer
authors.forename: Fred W
authors.initials: FW
authors.lastname: Lorey
mesh_terms: D002140:California / Q000453:epidemiology; D003409:Congenital Hypothyroidism; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000453:epidemiology*; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D015997:Neonatal Screening; D010472:Perchlorates / Q000633:toxicity*; D017670:Sodium Compounds / Q000633:toxicity*; D013972:Thyrotropin / Q000097:blood; D014874:Water Pollutants, Chemical / Q000009:adverse effects* / Q000032:analysis; D014877:Water Pollution, Chemical / Q000009:adverse effects* / Q000032:analysis; D014881:Water Supply / Q000032:analysis*
chemical_list: D010472:Perchlorates; D017670:Sodium Compounds; D014874:Water Pollutants, Chemical; D013972:Thyrotropin; C031068:sodium perchlorate