A general synthesis of 1-aryl carbamoyl-2-alkyl-4-aryl substituted semicarbazides as nonbasic factor Xa inhibitors.
An efficient four-step synthesis of 1-aryl-carbamoyl-2-alkyl-4-aryl-semicarbazides starting from benzophenone hydrazone is described leading to moderately active neutral factor Xa inhibitors.
Mederski
Werner W K R
WW
Merck KGaA, Preclinical Pharmaceutical Research, 64271 Darmstadt, Germany. mederski@merck.de
Germann
Martina
M
D000473:Alkanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology*; D065427:Factor Xa Inhibitors; D008968:Molecular Conformation; D012663:Semicarbazides / Q000138:chemical synthesis* / Q000494:pharmacology*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000473:Alkanes; D002219:Carbamates; D065427:Factor Xa Inhibitors; D012663:Semicarbazides; D015842:Serine Proteinase Inhibitors