title: Treatment of ulcerative colitis patients by long-term administration of germinated barley foodstuff: multi-center open trial.
abstract: Germinated barley foodstuff (GBF), which mainly consists of dietary fiber and glutamine-rich protein, is a prebiotic for ulcerative colitis (UC). In our previous study, we carried out a clinical trial of GBF with mildly to moderately active UC patients and showed that GBF treatment was able to attenuate the symptoms of UC in a relatively short-term. The aim of this study was to investigate the efficacy of long-term administration of GBF in the treatment of UC in a multi-center open trial. Twenty-one patients with mildly to moderately active UC received 20-30 g of GBF for 24 weeks in an open-label protocol while baseline treatments (5-amino-salicyrate compounds and/or steroids) were continued. The response to the GBF treatment was evaluated using a clinical scoring and after 24 weeks of observation, the GBF group showed a significant decrease in clinical activity index (especially, the degree of visible blood in stools and the presence of nocturnal diarrhea) compared with the control group (p<0.05). No side effects related to GBF were observed. In conclusion, GBF can reduce the clinical activity of UC over long-term as well as short-term administration. Nutraceutical GBF therapy may have a place in long-term management of UC, but controlled studies are needed to demonstrate its efficacy in the treatment of this disorder.
authors.affiliation: Nutrient Food & Feed Division, Kirin Brewery Co. Ltd., Tokyo 104-8288, Japan. kanauchio@kirin.co.jp
authors.forename: Osamu
authors.initials: O
authors.lastname: Kanauchi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Mitsuyama
authors.forename: Terasu
authors.initials: T
authors.lastname: Homma
authors.forename: Kazuya
authors.initials: K
authors.lastname: Takahama
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Fujiyama
authors.forename: Akira
authors.initials: A
authors.lastname: Andoh
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Araki
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Suga
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Hibi
authors.forename: Makoto
authors.initials: M
authors.lastname: Naganuma
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Asakura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakano
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimoyama
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hida
authors.forename: Ken
authors.initials: K
authors.lastname: Haruma
authors.forename: Hideki
authors.initials: H
authors.lastname: Koga
authors.forename: Michio
authors.initials: M
authors.lastname: Sata
authors.forename: Nobuo
authors.initials: N
authors.lastname: Tomiyasu
authors.forename: Atsushi
authors.initials: A
authors.lastname: Toyonaga
authors.forename: Masanobu
authors.initials: M
authors.lastname: Fukuda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kojima
authors.forename: Tadao
authors.initials: T
authors.lastname: Bamba
mesh_terms: D000328:Adult; D003085:Colic / Q000139:chemically induced; D003093:Colitis, Ulcerative / Q000178:diet therapy* / Q000473:pathology; D020685:Colonoscopes; D003967:Diarrhea / Q000139:chemically induced; D004043:Dietary Fiber / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005243:Feces; D001467:Hordeum / Q000737:chemistry; D006801:Humans; D008517:Phytotherapy; D028321:Plant Preparations / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D004043:Dietary Fiber; D028321:Plant Preparations