Production of age-related DNA strand breakage in brain cells of senescence-accelerated prone (SAMP1) mouse.
Amounts of DNA strand breaks were estimated by the proportion of cells without tails (PCWT) and the average lengths of tail momentum (ALTM) in comet images of tissue cells of senescence-accelerated prone (SAMP1) mouse and senescence-accelerated resistant (SAMR1) mouse. The PCWT and ALTM of brain cells from SAMR1 were unchanged from 4 to 15 months of age. In the case of SAMP1 brain cells, the PCWT decreased and the ALTM increased in an age-related manner from 8 to 15 months of age. In the cases of liver and kidney, the PCWT and the ALTM of both SAMP1 and SAMR1 cells showed constant values from 4 to 15 months of ages.
Hayashi
Masanobu
M
Department of Veterinary Radiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu 069-8501, Japan.
Nishida
Koga
K
Endoh
Daiji
D
Okui
Toyo
T
D000375:Aging / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000166:cytology*; D004249:DNA Damage; D051379:Mice; D008806:Mice, Inbred AKR / Q000502:physiology*