The comparison of the prognosis between Epstein-Barr virus (EBV)-positive gastric carcinomas and EBV-negative ones.
The relationship between the degree of lymphocytic infiltration into the tumor and the prognosis has not been completely evaluated between Epstein-Barr virus (EBV)-positive and -negative gastric carcinoma (GC). Although the average numbers and the grades of the infiltrating CD8+T cells, natural killer cells, dendritic cells, Ki67-positive cells were significantly greater in EBV-positive GCs than in -negative GCs, there was no significant survival improvement in EBV-positive group. These findings suggest that the infiltration of lymphocytes in the EBV-positive GC does not necessarily meant better prognosis and that the EBV status is not a significant prognostic factor in the patients with gastric cancer.
Kijima
Yuko
Y
Department of Surgical Oncology and Digestive Surgery, Kagoshima University, 8-35-1 Sakuragaoka, 890-8520, Kagoshima, Japan. ykijima@m3.kufm.kagoshima-u.ac.jp
Ishigami
Sumiya
S
Hokita
Shuichi
S
Koriyama
Chihaya
C
Akiba
Suminori
S
Eizuru
Yoshito
Y
Aikou
Takashi
T
D000368:Aged; D002277:Carcinoma / Q000821:virology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D016246:Lymphocytes, Tumor-Infiltrating; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012367:RNA, Viral / Q000032:analysis; D013274:Stomach Neoplasms / Q000821:virology*
C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral