title: Uranium gastrointestinal absorption: the f1 factor in humans.
abstract: The present investigation was undertaken by the Department of Health, Canada, to determine the most appropriate value to use for uranium gastrointestinal absorption (f1) in setting the guideline for drinking water. Fifty participants, free from medical problems, were recruited from two communities: a rural area where drinking water, supplied from drilled wells, contained elevated levels of uranium and an urban area where the water supplied by the municipal water system contained < 1 microg l(-1). Uranium intake through food, drinking water and other beverages was monitored using the duplicate diet approach. Intake and excretion were measured by inductively coupled plasma-mass spectrometry (ICP-MS) in samples collected concurrently from the same individuals over a 3 d period. The range of f1 values was between 0.001 and 0.06, with a median of 0.009. These values were independent of gender, age, duration of exposure, daily total uranium intake and allocation of intake between food and water. Consistent with the recommendation of ICRP Publication 69, 78% were below 0.02.
authors.affiliation: Radiation Protection Bureau, Health Canada (Address Locator: 6302 D1), 775 Brookfield Road, Ottawa, K1A 1C1, Canada. Maria_Zamora@hc-sc.gc.ca
authors.forename: M
authors.initials: M
authors.lastname: Limson Zamora
authors.forename: J M
authors.initials: JM
authors.lastname: Zielinski
authors.forename: D
authors.initials: D
authors.lastname: Meyerhof
authors.forename: G
authors.initials: G
authors.lastname: Moodie
authors.forename: R
authors.initials: R
authors.lastname: Falcomer
authors.forename: B
authors.initials: B
authors.lastname: Tracy
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D000367:Age Factors; D000368:Aged; D001822:Body Burden; D002170:Canada; D004064:Digestive System / Q000378:metabolism*; D005243:Feces / Q000737:chemistry*; D005260:Female; D005507:Food Contamination, Radioactive / Q000032:analysis*; D006801:Humans; D007408:Intestinal Absorption / Q000502:physiology; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D008875:Middle Aged; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D012737:Sex Factors; D014501:Uranium / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D014875:Water Pollutants, Radioactive / Q000032:analysis / Q000493:pharmacokinetics* / Q000652:urine*
chemical_list: D014875:Water Pollutants, Radioactive; D014501:Uranium