Studies on brain biogenic amines in methanolic extract of Cuscuta reflexa Roxb. and Corchorus olitorius Linn. seed treated mice.
The methanolic extract of both Cuscuta reflexa stem and Corchorus olitorius seed showed marked protection against convulsion induced by chemoconvulsive agents in mice. The catecholamines contained were significantly increased in the processed extract treated mice. The amount of GABA, which is most likely to be involved in seizure activity, was increased significantly in mice brain after a six week treatment. Results of the present study revealed that both the processed extracts showed a significant anticonvulsive property by altering the level of catecholamines and brain amino acids in mice.
Gupta
Malaya
M
Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700 032, India.
Mazumder
Upal Kanti
UK
Pal
Dilipkumar
D
Bhattacharya
Shiladitya
S
Chakrabarty
Sumit
S
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001679:Biogenic Amines / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism; D003292:Convulsants; D032381:Corchorus / Q000737:chemistry*; D034182:Cuscuta / Q000737:chemistry*; D008297:Male; D051379:Mice; D018377:Neurotransmitter Agents / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012701:Serotonin / Q000378:metabolism; D013331:Strychnine
D000927:Anticonvulsants; D001679:Biogenic Amines; D002395:Catecholamines; D003292:Convulsants; D018377:Neurotransmitter Agents; D010936:Plant Extracts; D012701:Serotonin; D013331:Strychnine