[Sildenafil as a substitute for subcutaneous prostacyclin in pulmonary hypertension].
Subcutaneous prostacyclin (treprostinil) is an effective short-term treatment for pulmonary hypertension. The most frequently described adverse effect-pain in the area of injection-rarely requires that treatment be withdrawn. Sildenafil is a selective fosfodiesterase-5 inhibitor with pulmonary vasodilating effects. We describe the use of sildenafil as a substitute for treprostinil in a patient with pulmonary hypertension associated with lupus erythematosus. Treatment with treprostinil was discontinued due to uncontrollable abdominal pain.
Cea-Calvo
L
L
Unidad de Hipertensión Pulmonar, Insuficiencia Cardíaca y Trasplante Cardíaco. Servicio de Cardiología. Hospital Universitario 12 de Octubre. Madrid. España. med022585@saludalia.com
Escribano Subías
P
P
Tello de Menesses
R
R
Gómez Sánchez
M A
MA
Delgado Jiménez
J F
JF
Sáenz de la Calzada
C
C
D015746:Abdominal Pain / Q000139:chemically induced; D000328:Adult; D011464:Epoprostenol / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D014665:Vasodilator Agents / Q000009:adverse effects / Q000627:therapeutic use*
D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate; D011464:Epoprostenol; C427248:treprostinil