Rapid and efficient synthesis of 1H-indol-2-yl-1H-quinolin-2-ones.
[reaction: see text] A concise and efficient synthesis of the novel indol-2-yl-1H-quinolin-2-one ring system found in the potent and selective KDR kinase inhibitors 1-3 is presented.
Kuethe
Jeffrey T
JT
Department of Process Research, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA.
Wong
Audrey
A
Davies
Ian W
IW