title: Non-linear, non-invasive method for seizure anticipation in focal epilepsy.
abstract: In this paper we discuss an approach, using methods of non-linear time series analysis applied to scalp electrode recordings, which is able to distinguish between epochs temporally distant from and just prior to, the onset of a seizure in patients with temporal lobe epilepsy. The method involves a comparison of recordings taken from electrodes adjacent to and remote from the site of ictal onset. In particular, we define a non-linear quantity which we call 'marginal predictability'. This quantity is computed using data from remote and from adjacent electrodes. We find that the difference between the marginal predictabilities computed for the remote and adjacent electrodes decreases several tens of minutes prior to seizure onset, compared to its value interictally.
authors.affiliation: Department of Physics, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Dingzhou
authors.initials: D
authors.lastname: Li
authors.forename: Weiping
authors.initials: W
authors.lastname: Zhou
authors.forename: Ivo
authors.initials: I
authors.lastname: Drury
authors.forename: Robert
authors.initials: R
authors.lastname: Savit
mesh_terms: D000293:Adolescent; D000328:Adult; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D017711:Nonlinear Dynamics; D011237:Predictive Value of Tests; D012640:Seizures / Q000175:diagnosis* / Q000517:prevention & control; D013223:Statistics as Topic / Q000379:methods*