title: Nuclease stability of LNA oligonucleotides and LNA-DNA chimeras.
abstract: The stabilizing properties of LNA and alpha-L-LNA oligonucleotides against endo- and 3'-exonucleases have been evaluated.
authors.affiliation: Cureon A/S, Copenhagen, Denmark.
authors.forename: Miriam
authors.initials: M
authors.lastname: Frieden
authors.forename: Henrik F
authors.initials: HF
authors.lastname: Hansen
authors.forename: Troels
authors.initials: T
authors.lastname: Koch
mesh_terms: D004247:DNA / Q000737:chemistry*; D004355:Drug Stability; D004722:Endoribonucleases / Q000378:metabolism; D005092:Exonucleases / Q000378:metabolism*; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense / Q000737:chemistry*; D043264:Phosphodiesterase I; D013379:Substrate Specificity
chemical_list: D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; C477371:locked nucleic acid; C027903:oligo (dT); D004247:DNA; D004722:Endoribonucleases; D005092:Exonucleases; C022650:spleen exonuclease; D043264:Phosphodiesterase I; C470790:phosphodiesterase I, snake venom