Olefinic peptide nucleic acid (OPA).
The olefinic peptide nucleic acid analogues (OPA) monomers containing the bases thymine and adenine were synthesised in 11 steps. Fully modified oligomers containing these units were prepared and their pairing properties assessed by means of UV-melting experiments.
Gautschi
Daniel
D
Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.
Leumann
Christian J
CJ
D000225:Adenine; D000475:Alkenes; D020029:Base Pairing; D001483:Base Sequence; D013058:Mass Spectrometry; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D013941:Thymine
D000475:Alkenes; D009838:Oligodeoxyribonucleotides; D020135:Peptide Nucleic Acids; D000225:Adenine; D013941:Thymine