Effects of insulin and adrenalectomy on elevation of serum leptin levels induced by 5-hydroxytryptophan in mice.
We previously reported that a serotonin precursor 5-hydroxytryptophan (5-HTP) increases serum leptin levels in mice. In this study, we studied the effects of insulin and adrenalectomy on hyperleptinemia induced by 5-HTP. Co-administration of insulin significantly increased hyperleptinemia elicited by 5-HTP. 5-HTP itself increased serum insulin levels. Adrenalectomy, which depletes corticosterone, did not abolish hyperleptinemic effects of 5-HTP. These results suggest that insulin may participate in hyperleptinemic effects of 5-HTP and that the involvement of corticosterone in effects of 5-HTP may be probably small.
Yamada
Jun
J
Department of Pharmacology, Kobe Pharmaceutical University, Kobe, Japan. j-yamada@kobepharma-u.ac.jp
Sugimoto
Yumi
Y
Ujikawa
Masanori
M
D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000315:Adrenalectomy / Q000379:methods*; D000818:Animals; D007328:Insulin / Q000097:blood / Q000494:pharmacology*; D020738:Leptin / Q000097:blood*; D008297:Male; D051379:Mice
D007328:Insulin; D020738:Leptin; D006916:5-Hydroxytryptophan