Asthma symptoms, severity, and drug therapy: a prospective study of effects on 2205 pregnancies.
OBJECTIVE
To prospectively examine in pregnant women whether asthma or asthma therapy influenced preterm delivery, intrauterine grown restriction (IUGR), or birthweight.


METHODS
We enrolled 873 pregnant women with a history of asthma, of whom 778 experienced asthma symptoms or took medication, and 1333 women with no asthma history, including 884 women with neither asthma diagnosis nor symptoms and 449 with symptoms but no diagnosis. Asthma symptoms, medication, and severity were classified according to 2002 Global Initiative for Asthma guidelines.


RESULTS
Preterm delivery was not associated with asthma diagnosis, severity, or symptoms but was associated with use of controller medications, independent of symptoms, specifically oral steroids and theophylline. Gestation was reduced by 2.22 weeks in women using oral steroids daily (P =.001) and 1.11 weeks after theophylline (P =.002). We observed a 24% (5-47%) increased risk for IUGR with each increased symptom step, which increased further in symptomatic women with no asthma diagnosis (31%, 4-65%) compared with women with neither asthma nor symptoms.


CONCLUSIONS
We found no effect of asthma symptoms or severity on preterm delivery but observed increased risks associated with use of oral steroid and theophylline. Intrauterine growth restriction was associated with asthma severity, which possibly reflects a hypoxic fetal effect. Women with asthma symptoms but no diagnosis were at particular risk of undermedication and delivering IUGR infants. These observations support guidelines that advocate active management of pregnant patients with mild or moderate asthma with beta(2) agonists, with oral steroids added only if severity increases. Symptomatic patients without an asthma diagnosis might need to be equally managed.
Bracken
Michael B
MB
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA. michael.bracken@yale.edu
Triche
Elizabeth W
EW
Belanger
Kathleen
K
Saftlas
Audrey
A
Beckett
William S
WS
Leaderer
Brian P
BP
D000328:Adult; D018927:Anti-Asthmatic Agents / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D001249:Asthma / Q000188:drug therapy* / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D001724:Birth Weight; D016022:Case-Control Studies; D003237:Connecticut / Q000453:epidemiology; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D005322:Premature Rupture of Fetal Membranes / Q000209:etiology; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008404:Massachusetts / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy* / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013256:Steroids; D013806:Theophylline / Q000009:adverse effects
D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D013256:Steroids; D013806:Theophylline