Interplay of chemotaxis and chemokinesis mechanisms in bacterial dynamics.
Motivated by observations of the dynamics of Myxococcus xanthus, we present a self-interacting random walk model that describes the competition between chemokinesis and chemotaxis. Cells are constrained to move in one dimension, but release a chemical chemoattractant at a steady state. The bacteria sense the chemical that they produce. The probability of direction reversals is modeled as a function of both the absolute level of chemoattractant sensed directly under each cell as well as the gradient sensed across the length of the cell. If the chemical does not degrade or diffuse rapidly, the one-dimensional trajectory depends on the entire past history of the trajectory. We derive the corresponding Fokker-Planck equations, use an iterative mean-field approach that we solve numerically for short times, and perform extensive Monte Carlo simulations of the model. Cell positional distributions and the associated moments are computed in this feedback system. Average drift and mean squared displacements are found. Crossover behaviors among different diffusion regimes are found.
D'Orsogna
Maria R
MR
Department of Physics and Astronomy, University of California, Los Angeles, California 90095-1547, USA.
Suchard
Marc A
MA
Chou
Tom
T
D018407:Bacterial Physiological Phenomena; D055592:Biophysical Phenomena; D001703:Biophysics; D002465:Cell Movement; D018925:Chemokines / Q000378:metabolism; D002630:Chemotactic Factors; D002633:Chemotaxis; D003198:Computer Simulation; D004058:Diffusion; D004926:Escherichia coli / Q000378:metabolism; D008954:Models, Biological; D015233:Models, Statistical; D008962:Models, Theoretical; D009010:Monte Carlo Method; D016941:Myxococcus xanthus / Q000378:metabolism
D018925:Chemokines; D002630:Chemotactic Factors