Prospective study of high-dose chemotherapy and autologous peripheral stem cell transplantation in adult patients with advanced desmoplastic small round-cell tumour.
A total of 10 desmoplastic small round-cell tumour patients were treated by high-dose chemotherapy with stem cell support. After high-dose chemotherapy, no complete response conversion was obtained and EWS-WT1 fusion transcript detection was positive in the peripheral blood during follow-up in all patients. High-dose chemotherapy did not seem to change the results in desmoplastic small round-cell tumour.
Bertuzzi
A
A
Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Via Manzoni 56, Rozzano, Milan 20089, Italy.
Castagna
L
L
Quagliuolo
V
V
Ginanni
V
V
Compasso
S
S
Magagnoli
M
M
Balzarotti
M
M
Nozza
A
A
Siracusano
L
L
Timofeeva
I
I
Sarina
B
B
Parra
H Soto
HS
Santoro
A
A
D000008:Abdominal Neoplasms / Q000235:genetics / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D018288:Carcinoma, Small Cell / Q000235:genetics / Q000628:therapy*; D003131:Combined Modality Therapy; D017931:DNA Primers / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000378:metabolism; D036102:Peripheral Blood Stem Cell Transplantation; D011379:Prognosis; D011446:Prospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015996:Survival Rate; D014182:Transplantation, Autologous; D016896:Treatment Outcome
D017931:DNA Primers; C106032:EWS1-WT1 fusion protein, human; D015514:Oncogene Proteins, Fusion