Extending chemoselective ligation to sugar chemistry: convergent assembly of bioactive neoglycoconjugates.
Glycoproteins and glycolipids play central roles in human health and disease, and their mimetics are primary candidates for drug development. Our understanding of the molecular level of phenomena based on molecular recognition of oligosaccharides by specific receptors has taken tremendous advantage from their chemical synthesis, which provides homogeneous material not attainable from biosynthetic systems. This review summarizes chemoselective approaches for the assembly of neoglycoconjugates. The objective of these methods is to make glycoconjugate synthesis accessible to a broader community, thus accelerating progress in biotechnology.
Peri
Francesco
F
Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy. francesco.peri@unimib.it
D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry*; D005947:Glucose / Q000737:chemistry*; D006017:Glycolipids / Q000138:chemical synthesis / Q000737:chemistry; D006023:Glycoproteins / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data; D013455:Sulfur / Q000737:chemistry
D002241:Carbohydrates; D006017:Glycolipids; D006023:Glycoproteins; D013455:Sulfur; D005947:Glucose