Thionucleotides as inhibitors of ribonucleotide reductase.
Ribonucleosides and xylonucleosides bearing a disulfide function on the sugar ring were synthesized. Ribonucleosides belonging to the cytidine series were found to efficiently reduce dNTP pools in the human lymphoblastoid CEM/SS cell line.
Roy
B
B
Institut de Biochimie Biophysique Moléculaire et Cellulaire, Université de Paris Sud, UMR CNRS 8619, Orsay, France.
Chambert
S
S
Lepoivre
M
M
Décout
J L
JL
D003562:Cytidine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology; D007202:Indicators and Reagents; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors*; D013873:Thionucleotides / Q000494:pharmacology*; D014994:Xylose
D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D013873:Thionucleotides; D003562:Cytidine; D014994:Xylose; D012264:Ribonucleotide Reductases