Fishing for novel angiogenic therapies.
The zebrafish has recently emerged as an important model for the study of vascular embryogenesis. Its genetic accessibility, external development, and optically clear embryo are just a few of the features that set the zebrafish apart as a particularly well-suited model for studying vascular development. However, there is little precedent for its use as a tool for the experimental study of therapeutic angiogenesis. Here, we review the use of the zebrafish for studying vascular development and patterning, and discuss how the zebrafish might be used more directly as a model for developing and testing effective therapeutic angiogenesis approaches.
Kidd
Kameha R
KR
Laboratory of Molecular Genetics, NICHD, NIH, Building 6B, Room 309, 6 Center Drive, Bethesda, MD 20892, USA.
Weinstein
Brant M
BM
D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000818:Animals; D001808:Blood Vessels / Q000196:embryology; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D023421:Models, Animal; D015027:Zebrafish / Q000033:anatomy & histology / Q000502:physiology
D043925:Angiogenesis Inducing Agents