title: Ultrastructural modifications in the mitochondrion of mouse Sertoli cells after inhalation of lead, cadmium or lead-cadmium mixture.
abstract: CD-1 mice inhaled 0.01 M lead acetate, 0.006 M cadmium chloride or Pb-Cd mixture during 1h twice a week during 4 weeks. Testes were processed for transmission electron microscopic analysis. The percentage of damaged mitochondria was related to exposure time and the type of metal inhaled, noticing more damage when the mixture was administered. A dose-time relationship was found. Cadmium chloride caused the most severe mitochondrial alteration compared to lead acetate, whereas the mixture was more aggressive compared with each metal alone. Our results suggest that the changes in Sertoli cell could lead to a transformation process that may interfere with spermatogenesis.
authors.affiliation: Departamento de Biologi;a Celular y Tisular, Facultad de Medicina, Edificio A 3er piso, UNAM, Mexico City, CP 04510, Mexico.
authors.forename: Patricia
authors.initials: P
authors.lastname: Bizarro
authors.forename: Sandra
authors.initials: S
authors.lastname: Acevedo
authors.forename: Geraldine
authors.initials: G
authors.lastname: Niño-Cabrera
authors.forename: Patricia
authors.initials: P
authors.lastname: Mussali-Galante
authors.forename: Francisco
authors.initials: F
authors.lastname: Pasos
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Avila-Costa
authors.forename: Teresa I
authors.initials: TI
authors.lastname: Fortoul
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D002104:Cadmium / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007854:Lead / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D008670:Metals / Q000633:toxicity*; D051379:Mice; D008815:Mice, Inbred Strains; D008928:Mitochondria / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure*; D012708:Sertoli Cells / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure*; D013997:Time Factors
chemical_list: D008670:Metals; D002104:Cadmium; D007854:Lead