title: Alpha-hydroxybenzylphosphonate modified oligonucleotides: synthesis, properties, and a novel route via monomer building blocks.
abstract: In general, alpha-hydroxybenzylphosphonate modified 2'-deoxyadenosine-thymidine dimer building blocks 1, 2 are utilized for the incorporation into alpha-hydroxybenzylphosphonate pro-oligonucleotides. For a universal application of our pro-oligonucleotide concept on biologically relevant oligonucleotides a route for the synthesis of modified monomer building blocks 3 was developed and is presented herein.
authors.affiliation: Institute of Organic Chemistry, University of Hamburg, Hamburg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Hohlfeld
authors.forename: Chris
authors.initials: C
authors.lastname: Meier
mesh_terms: D007202:Indicators and Reagents; D008968:Molecular Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis*; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis / Q000737:chemistry; D063065:Organophosphonates / Q000737:chemistry*
chemical_list: D007202:Indicators and Reagents; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; D063065:Organophosphonates