Conjugates of oligo(2'-O-methylribonucleotides) with minor groove binders as new sequence-specific agents recognizing both grooves of double-stranded DNA.
Design, synthesis and physico-chemical studies of new pyrimidine oligo(2'-O-methylribonucleotide) conjugates with one or two oligo(pyrrolecarboxamide) minor groove binders (MGB) are described.
Novopashina
D
D
Novosibirsk Institute of Bioorganic Chemistry SB RAS, Novosibirsk, Russia. dasha@ngs.ru
Sinyakov
A
A
Ryabinin
V
V
Venyaminova
A
A
Boutorine
A
A
D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D007202:Indicators and Reagents; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D011743:Pyrimidines
D007202:Indicators and Reagents; D009843:Oligoribonucleotides; D011743:Pyrimidines; D004247:DNA