title: Bioavailability of iron, zinc, folate, and vitamin C in the IRIS multi-micronutrient supplement: effect of combination with a milk-based cornstarch porridge.
abstract: The effect of combining a multi-micronutrient supplement with a milk-based cornstarch porridge on the bioavailability of iron, zinc, folate, and vitamin C was evaluated using the plasma curve response over time (8 hours) in healthy women. Three tests were carried out in a crossover design: S (multi-micronutrient supplement), MS (multi-micronutrient supplement plustest meal), and M (test meal). Relative bioavailability was determined as the percent ratio of the area under the curve (AUC) in MS corrected by M, and AUC in S. Compared to S, AUC in MS was smaller for iron (p < .05), for zinc (p < .01), and for folate (p < .05), but not different for vitamin C. Relative bioavailability was lower (p < .05) than 100% for iron (80%), zinc (70%), and folate (85%). The decrease in bioavailability of these nutrients when the multi-micronutrient supplement is combined with a milk-based cornstarch porridge is small. Therefore, the tested meal is a suitable vehicle for the multi-micronutrient supplement.
authors.affiliation: Laboratório de Bioquímica Nutricional e de Alimentos, Instituto de Química, Universidade Federal in Rio de Janeiro, Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Kamp
authors.forename: Doris
authors.initials: D
authors.lastname: Jandel
authors.forename: Imke
authors.initials: I
authors.lastname: Hoenicke
authors.forename: Klaus
authors.initials: K
authors.lastname: Pietrzk
authors.forename: Rainer
authors.initials: R
authors.lastname: Gross
authors.forename: Nadia M
authors.initials: NM
authors.lastname: Trugo
authors.forename: Carmen M
authors.initials: CM
authors.lastname: Donangelo
mesh_terms: D000328:Adult; D000818:Animals; D019540:Area Under Curve; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D001682:Biological Availability; D018592:Cross-Over Studies; D003611:Dairy Products; D003677:Deficiency Diseases / Q000097:blood / Q000517:prevention & control*; D019587:Dietary Supplements; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D018565:Food-Drug Interactions; D006801:Humans; D007408:Intestinal Absorption; D019266:Iron, Dietary / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D018977:Micronutrients / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008875:Middle Aged; D015032:Zinc / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics
chemical_list: D019266:Iron, Dietary; D018977:Micronutrients; D005492:Folic Acid; D015032:Zinc; D001205:Ascorbic Acid