Hematologic abnormalities in severe neonatal necrotizing enterocolitis: 25 years later.
Necrotizing enterocolitis (NEC), the most common surgical emergency in newborns, remains a therapeutic challenge for clinicians. The hematological manifestations associated with NEC were first described 25 years ago. This review discusses current knowledge of the pathophysiology involved in disturbances in megakaryocytopoiesis, coagulation, leukopoiesis, and erythropoiesis that accompany the clinical entity NEC. The discussion includes current understanding of and potential strategies for treating the hematopoietic disturbances that occur secondary to NEC.
Kling
Pamela J
PJ
Department of Pediatrics, University of Wisconsin, 6 Center Meriter Hospital, 202 South Park Street, Madison, WI 53715, USA.
Hutter
John J
JJ
D020345:Enterocolitis, Necrotizing / Q000150:complications*; D006402:Hematologic Diseases / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn