title: 1H-NMR study of the quadruplex [d(TGGGT)]4 containing a modified thymine.
abstract: A NMR structural study of quadruplex [d(TGGGT)]4 containing a modified thymine is reported. The three dimensional structure of the complex is very similar to those of other parallel stranded quadruplexes. The modified thymines (T*) are able, at least in the minimised structures, to form a tetrad containing extra H-bonds through the hydroxyl groups. Nevertheless, in this new tetrad the modified thymines are slightly open towards the solvent respect to the unmodified T-tetrad.
authors.affiliation: Dipartimento di Chimica, Università Federico II di Napoli, Naples, Italy.
authors.forename: Luigi
authors.initials: L
authors.lastname: Petraccone
authors.forename: Eva
authors.initials: E
authors.lastname: Erra
authors.forename: Lucia
authors.initials: L
authors.lastname: Nasti
authors.forename: Aldo
authors.initials: A
authors.lastname: Galeone
authors.forename: Antonio
authors.initials: A
authors.lastname: Randazzo
authors.forename: Veronica
authors.initials: V
authors.lastname: Esposito
authors.forename: Luciano
authors.initials: L
authors.lastname: Mayol
authors.forename: Guido
authors.initials: G
authors.lastname: Barone
authors.forename: Concetta
authors.initials: C
authors.lastname: Giancola
mesh_terms: D001483:Base Sequence; D006147:Guanine / Q000737:chemistry*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D009838:Oligodeoxyribonucleotides; D006147:Guanine