title: [Comparative choleretic properties of natural xanthone compounds from Gentianopsis barbata].
abstract: Comparative data are presented for the choleretic activity of xanthones isolated from Gentianopsis barbata (Froel.) Ma. (Gentianaceae family): a sum of xanthone glycosides (I) and aglycons (II); xanthone aglycons, including decussatin [1-(OH)-3,7,8-(OCH3)3] (III) and gentiacaulein [1,7-(OH)-3,8-(OCH3)2] (IV); and xanthone glycoside gentiabavaroside [1-O-primverosyl-7-(OH)-3,8-(OCH3)2] (V). It was established that (II) is superior to (I) with respect to cholagogic effect and is inferior to (III) and (IV) with respect to cholatostimulant action.
authors.affiliation: Laboratory of Experimental Pharmacology, Institute of General and Experimental Biology, Siberian Division, Russian Academy of Sciences, ul. Sakh'yanova 6, Ulan-Ude, 670047 Russia.
authors.forename: S M
authors.initials: SM
authors.lastname: Nikolaev
authors.forename: Z G
authors.initials: ZG
authors.lastname: Sambueva
authors.forename: A V
authors.initials: AV
authors.lastname: Tsyrenzhapov
authors.forename: G G
authors.initials: GG
authors.lastname: Nikolaeva
authors.forename: L M
authors.initials: LM
authors.lastname: Tankhaeva
authors.forename: V I
authors.initials: VI
authors.lastname: Glyzin
authors.forename: T D
authors.initials: TD
authors.lastname: Dargaeva
mesh_terms: D000818:Animals; D001646:Bile / Q000737:chemistry / Q000378:metabolism; D002756:Cholagogues and Choleretics / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D029965:Gentianaceae; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D014966:Xanthenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D002756:Cholagogues and Choleretics; D010936:Plant Extracts; D014966:Xanthenes