title: [Association between polymorphisms in the gene coding for glutathione S-transferase P1 and chronic obstructive pulmonary disease].
abstract: OBJECTIVE
  To investigate the association between polymorphisms in the gene coding for glutathione S-transferase P1 (GSTP1) and susceptibility to chronic obstructive pulmonary disease (COPD) in a Chinese population.
  
  
  METHODS
  This was a pilot study of the molecular epidemiology in patients with COPD. The research design was a case-control study. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) were performed to genotype GSTP1 polymorphisms in exon 5 in 100 COPD patients and 100 age and sex matched healthy controls. Logistic regression analysis method was used to calculate the odds ratio (OR) and the 95% confidence interval (CI).
  
  
  RESULTS
  There was no significant difference in GSTP1 polymorphisms adjusted by age, sex, body mass index and smoking between COPD patients and controls.
  
  
  CONCLUSIONS
  The gene polymorphism for GSTP1 was not associated with susceptibility to COPD in the Chinese population.
authors.affiliation: Beijing Chaoyang Hospital-Beijing Institute of Respiratory Medicine, Capital University of Medical Science, Beijing 100020, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Xiao
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.forename: Min-jie
authors.initials: MJ
authors.lastname: Du
authors.forename: Bao-sen
authors.initials: BS
authors.lastname: Pang
authors.forename: Hong-yu
authors.initials: HY
authors.lastname: Zhang
authors.forename: Bai
authors.initials: B
authors.lastname: Xiao
authors.forename: Jing-zhong
authors.initials: JZ
authors.lastname: Liu
authors.forename: Xin-zhi
authors.initials: XZ
authors.lastname: Weng
authors.forename: Li
authors.initials: L
authors.lastname: Su
authors.forename: David C
authors.initials: DC
authors.lastname: Christiani
mesh_terms: D000368:Aged; D002874:Chromosome Mapping; D005260:Female; D005838:Genotype; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics*
chemical_list: D007527:Isoenzymes; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase