title: Pancreatic resection for metastatic renal cell carcinoma: presentation, treatment, and outcome.
abstract: BACKGROUND
  The diverse natural history of renal cell carcinoma (RCC) includes metastases to the pancreas, a very unusual site for distant spread of other cancers. Considering the relatively indolent behavior of some cases of metastatic RCC, pancreatic resection is offered to select patients.
  
  
  METHODS
  We reviewed the records of patients at three affiliated university hospital centers who had prior nephrectomy for RCC and subsequent pancreatic resection of metastases.
  
  
  RESULTS
  Fourteen patients--9 women and 5 men with a median age of 63.8 years--underwent a total of 15 pancreatic resections for metastatic RCC. Nine (64%) had solitary metastases. The median interval from nephrectomy to diagnosis of pancreatic metastases was 83 months. The median size of metastases was 4.6 cm. There was one perioperative death. Pancreatic recurrence occurred in five patients (36%), and one patient underwent repeat resection. At a median follow-up of 32 months, seven patients (50%) are alive without evidence of disease, and four patients (28%) are alive with recurrent disease.
  
  
  CONCLUSIONS
  Resection of pancreatic metastases from RCC is associated with long-term survival and should be considered for patients in whom complete resection is possible.
authors.affiliation: Sunnybrook & Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Calvin H L
authors.initials: CH
authors.lastname: Law
authors.forename: Alice C
authors.initials: AC
authors.lastname: Wei
authors.forename: Sherif S
authors.initials: SS
authors.lastname: Hanna
authors.forename: Mohamed
authors.initials: M
authors.lastname: Al-Zahrani
authors.forename: Bryce R
authors.initials: BR
authors.lastname: Taylor
authors.forename: Paul D
authors.initials: PD
authors.lastname: Greig
authors.forename: Bernard
authors.initials: B
authors.lastname: Langer
authors.forename: Steven
authors.initials: S
authors.lastname: Gallinger
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000556:secondary* / Q000601:surgery*; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome