title: The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteins.
abstract: BACKGROUND
  Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding.
  
  
  RESULTS
  The TROVE module--Telomerase, Ro and Vault module--is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. This novel module, consisting of one or more domains, may be involved in binding the RNA components of the three RNPs, which are telomerase RNA, Y RNA and vault RNA. A second conserved region in these proteins is shown to be a member of the vWA domain family. The vWA domain in TEP1 is closely related to the previously recognised vWA domain in VPARP a second component of the vault particle. This vWA domain may mediate interactions between these vault components or bind as yet unidentified components of the RNPs.
  
  
  CONCLUSIONS
  This work suggests that a number of ribonucleoprotein components use a common RNA-binding module. The TROVE module is also found in bacterial ribonucleoproteins suggesting an ancient origin for these ribonucleoproteins.
authors.affiliation: The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK. agb@sanger.ac.uk
authors.forename: Alex
authors.initials: A
authors.lastname: Bateman
authors.forename: Valerie
authors.initials: V
authors.lastname: Kickhoefer
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D001324:Autoantigens / Q000737:chemistry*; D001426:Bacterial Proteins / Q000737:chemistry; D002352:Carrier Proteins / Q000737:chemistry; D003013:Clostridium / Q000201:enzymology; D000458:Cyanobacteria / Q000737:chemistry; D003589:Cytophaga / Q000201:enzymology; D034301:Deinococcus / Q000737:chemistry; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D015800:Protozoan Proteins / Q000737:chemistry; D011551:Pseudomonas fluorescens / Q000737:chemistry; D020733:RNA, Small Cytoplasmic; D016601:RNA-Binding Proteins / Q000737:chemistry; D012261:Ribonucleoproteins / Q000737:chemistry*; D012486:Salmonella typhimurium / Q000201:enzymology; D013302:Streptomyces / Q000201:enzymology; D019098:Telomerase / Q000737:chemistry*; D016615:Telomere / Q000201:enzymology; D013768:Tetrahymena / Q000201:enzymology / Q000235:genetics; D020394:Vault Ribonucleoprotein Particles / Q000737:chemistry*; D000099207:SS-A Antigen
chemical_list: D001324:Autoantigens; D001426:Bacterial Proteins; D002352:Carrier Proteins; D015800:Protozoan Proteins; D020733:RNA, Small Cytoplasmic; D016601:RNA-Binding Proteins; D012261:Ribonucleoproteins; D019098:Telomerase; D020394:Vault Ribonucleoprotein Particles; C116006:RO60 protein, human; D000099207:SS-A Antigen; C492050:Ssa2 protein, mouse; C104342:TEP1 protein, human; C498415:Tep1 protein, mouse; C498417:telomerase p80 protein, Tetrahymena