title: PRESS-based proton single-voxel spectroscopy and spectroscopic imaging with very short echo times using asymmetric RF pulses.
abstract: Modified point-resolved spectroscopy (PRESS) sequences for single voxel spectroscopy (MRS) and spectroscopic imaging (SI) with very short echo time ( T(E)) are described using asymmetric radio-frequency (RF) pulses as well as an optimized design and timing of the PRESS sequence. The proposed sequences were implemented on a standard 4.7 T imaging system yielding a T(E) of 6.0 ms only. Simulations and experimental data measured on phantoms and the rat brain in vivo are presented for MRS and SI showing a high signal-to-noise ratio and hardly any phase distortions caused by J-coupling.
authors.affiliation: Fachbereich 2 (Chemie), Universität Bremen, Leobener Strasse, 28334 Bremen, Germany.
authors.forename: Christian
authors.initials: C
authors.lastname: Geppert
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Dreher
authors.forename: Dieter
authors.initials: D
authors.lastname: Leibfritz
mesh_terms: D000465:Algorithms; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D001931:Brain Mapping / Q000379:methods; D007089:Image Enhancement / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D019047:Phantoms, Imaging; D011846:Radio Waves; D051381:Rats; D012815:Signal Processing, Computer-Assisted