title: Application of support vector machines for T-cell epitopes prediction.
abstract: BACKGROUND
  The T-cell receptor, a major histocompatibility complex (MHC) molecule, and a bound antigenic peptide, play major roles in the process of antigen-specific T-cell activation. T-cell recognition was long considered exquisitely specific. Recent data also indicate that it is highly flexible, and one receptor may recognize thousands of different peptides. Deciphering the patterns of peptides that elicit a MHC restricted T-cell response is critical for vaccine development.
  
  
  RESULTS
  For the first time we develop a support vector machine (SVM) for T-cell epitope prediction with an MHC type I restricted T-cell clone. Using cross-validation, we demonstrate that SVMs can be trained on relatively small data sets to provide prediction more accurate than those based on previously published methods or on MHC binding.
  
  
  BACKGROUND
  Data for 203 synthesized peptides is available at http://linus.nci.nih.gov/Data/LAU203_Peptide.pdf
authors.affiliation: Biometric Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Yingdong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Clemencia
authors.initials: C
authors.lastname: Pinilla
authors.forename: Danila
authors.initials: D
authors.lastname: Valmori
authors.forename: Roland
authors.initials: R
authors.lastname: Martin
authors.forename: Richard
authors.initials: R
authors.lastname: Simon
mesh_terms: D000465:Algorithms; D000936:Antigen-Antibody Complex / Q000737:chemistry* / Q000378:metabolism*; D001185:Artificial Intelligence; D016000:Cluster Analysis; D030562:Databases, Protein; D018984:Epitopes, T-Lymphocyte / Q000737:chemistry* / Q000378:metabolism*; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000378:metabolism; D016571:Neural Networks, Computer; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020539:Sequence Analysis, Protein / Q000379:methods*; D013329:Structure-Activity Relationship
chemical_list: D000936:Antigen-Antibody Complex; D018984:Epitopes, T-Lymphocyte; D015395:Histocompatibility Antigens Class I