New styryl sulfones as anticancer agents.
New styryl sulfone compounds have been synthesized and evaluated for their anti-proliferative activity. Among the compounds synthesized, one compound (7k) has shown 51% tumor growth inhibition in mice implanted with HT-29 human carcinoma at 400 mg kg(-1) orally.
Vedula
Manohar Sharma
MS
Discovery Chemistry, Discovery Research, Dr. Reddy's Laboratories, Bollaram Road, 500 050, Hyderabad, India. sarmavm@dreddys.com
Pulipaka
Aravind Babu
AB
Venna
Chandrasekhar
C
Chintakunta
Vamsee Krishna
VK
Jinnapally
Sreenu
S
Kattuboina
Venkata Adiseshu
VA
Vallakati
Ravi Krishna
RK
Basetti
Vishnu
V
Akella
Venkateswarlu
V
Rajgopal
Sriram
S
Reka
Ajaya Kumar
AK
Teepireddy
Sravan Kumar
SK
Mamnoor
Prem Kumar
PK
Rajagopalan
Ramanujam
R
Bulusu
Gopalakrishnan
G
Khandelwal
Akash
A
Upreti
Vijay V
VV
Mamidi
Srinivas Rao
SR
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D019073:HT29 Cells; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D015394:Molecular Structure; D013450:Sulfones / Q000138:chemical synthesis / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays
D000970:Antineoplastic Agents; D013450:Sulfones