title: Pharmacokinetic study of ellagic acid in rat after oral administration of pomegranate leaf extract.
abstract: Quantification of ellagic acid, the principal bioactive component of pomegranate leaf extract, in rats plasma following oral administration of pomegranate leaf extract was achieved by using a high-performance liquid chromatographic method. The calibration curve for ellagic acid was linear (r2=0.9998) ver the concentration range 0.026-1.3 microg/ml. The intra- and inter-day assays of ellagic acid from rat plasma were less than 6.52% at concentration range from 26 to 1300 ng/ml and good overall recoveries (94.5-102.4%) were found on same concentrations. The concentration-time profile was fitted with an open two-compartment system with lag time and its max concentration of ellagic acid in plasma was 213 ng/ml only 0.55 h after oral administration extract 0.8 g/kg. The pharmacokinetic profile indicates that ellagic acid has poor absorption and rapid elimination after oral administration pomegranate leaf extract, and part of it was absorbed from stomach.
authors.affiliation: Institute of Medicinal Plant, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100094, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Lei
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Xing
authors.forename: Lan
authors.initials: L
authors.lastname: Xiang
authors.forename: Yu-Nan
authors.initials: YN
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Lu-Jun
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Du
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004610:Ellagic Acid / Q000097:blood / Q000493:pharmacokinetics*; D029561:Lythraceae / Q000737:chemistry*; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D004610:Ellagic Acid