Anticonvulsant activity of benzylamides of some amino acids and heterocyclic acids.
A series of new potential anticonvulsants have been synthesized. They are N-methyl benzyl-amides of N-methyl Asp and N-methyl Glu (R and S), benzylamides of some heterocyclic acids and their N-oxides and benzylamides of two heteroalicyclic acids. The obtained compounds were evaluated in the Anticonvulsant Screening Project (ASP) of Antiepileptic Drug Development Program (ADDP) of NIH.
Paruszewski
Ryszard
R
Department of Drug Chemistry, Medical University, Warszawa, Poland.
Strupińska
Marzanna
M
Rostafińska-Suchar
Graźyna
G
Stables
James P
JP
D000284:Administration, Oral; D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology*; D000596:Amino Acids / Q000737:chemistry; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D001593:Benzyl Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical; D006571:Heterocyclic Compounds / Q000737:chemistry; D021281:Quantitative Structure-Activity Relationship; D051381:Rats
D000577:Amides; D000596:Amino Acids; D000927:Anticonvulsants; D001593:Benzyl Compounds; D006571:Heterocyclic Compounds