Functional proteomics of receptor-Ck in the developmental stages of human atherosclerotic arterial wall.
BACKGROUND
The study was undertaken to understand the relationship between the functional proteomics of receptor-Ck and developmental stages of human atherosclerotic aortic wall.


RESULTS
Gene expression study of 25 aortas was undertaken and the results revealed a gradual increase in receptor-Ck gene expression paralleled by the regulatory response of its effector genes coding for sterol response element-binding protein, p27, cyclin D, interleukin-6 and CD40 from a normal to atherosclerotic arterial wall (viz. fatty streak and fibrofatty/fibrous plaque).


CONCLUSIONS
Based upon this and our earlier studies, we propose that cholesterol-specific receptor-Ck-dependent gene regulation may be of crucial importance in atherogenesis.
Kaul
D
D
Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh.
Kaur
R
R
Baba
I
I
Singh
D
D
D001011:Aorta / Q000503:physiopathology; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics; D003324:Coronary Artery Disease / Q000235:genetics / Q000503:physiopathology*; D056741:Cyclin D; D016213:Cyclins / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000235:genetics / Q000502:physiology; D006801:Humans; D007194:India; D015850:Interleukin-6 / Q000235:genetics; D008840:Microfilament Proteins / Q000235:genetics; D008875:Middle Aged; D009124:Muscle Proteins; D040901:Proteomics; D018110:Receptors, Lipoprotein / Q000235:genetics / Q000502:physiology*; D051780:Sterol Regulatory Element Binding Protein 1; D048008:TNF Receptor-Associated Factor 3; D014157:Transcription Factors; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
D022762:CCAAT-Enhancer-Binding Proteins; D002352:Carrier Proteins; D056741:Cyclin D; D016213:Cyclins; D004268:DNA-Binding Proteins; D015850:Interleukin-6; D008840:Microfilament Proteins; D009124:Muscle Proteins; D018110:Receptors, Lipoprotein; C497387:SREBF1 protein, human; D051780:Sterol Regulatory Element Binding Protein 1; D048008:TNF Receptor-Associated Factor 3; C090656:TRAF3 protein, human; C058992:Tagln protein, mouse; D014157:Transcription Factors; D047988:Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; C113493:receptor-Ck