A role for the ubiquitin-26S-proteasome pathway in gibberellin signaling.
The gibberellin (GA) signaling pathway, like auxin and jasmonate signaling, uses the ubiquitin-proteasome pathway to control expression through protein degradation. A conserved F-box protein of an SCF E3 ubiquitin ligase is a positive regulator of GA signaling in Arabidopsis and rice. GA apparently stimulates stem elongation by causing this SCF complex to regulate negatively a family of negative regulators of GA response (the DELLA family of putative transcription factors). The DELLA family members AtRGA or (Repressor of ga1-3) and OsSLR1 (SLENDER RICE1) proteins both appear to be subject to GA-induced proteolysis. The need to have the F-box genes AtSLY1 and OsGID2 for this proteolysis suggests that GA causes proteolysis of AtRGA/OsSLR1 via the SCF(AtSLY1/OsGID2) ubiquitin ligase.
Itoh
Hironori
H
Bioscience and Biotechnology Center, Nagoya University, Chikusa, Nagoya 464-8601, Japan.
Matsuoka
Makoto
M
Steber
Camille M
CM
D000595:Amino Acid Sequence; D005875:Gibberellins / Q000378:metabolism*; D008969:Molecular Sequence Data; D010447:Peptide Hydrolases / Q000378:metabolism*; D010944:Plants / Q000235:genetics / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism*
D005875:Gibberellins; D014157:Transcription Factors; D025801:Ubiquitin; D010447:Peptide Hydrolases; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease