1H-NMR study of the quadruplex [d(TGGGT)]4 containing a modified thymine.
A NMR structural study of quadruplex [d(TGGGT)]4 containing a modified thymine is reported. The three dimensional structure of the complex is very similar to those of other parallel stranded quadruplexes. The modified thymines (T*) are able, at least in the minimised structures, to form a tetrad containing extra H-bonds through the hydroxyl groups. Nevertheless, in this new tetrad the modified thymines are slightly open towards the solvent respect to the unmodified T-tetrad.
Petraccone
Luigi
L
Dipartimento di Chimica, Università Federico II di Napoli, Naples, Italy.
Erra
Eva
E
Nasti
Lucia
L
Galeone
Aldo
A
Randazzo
Antonio
A
Esposito
Veronica
V
Mayol
Luciano
L
Barone
Guido
G
Giancola
Concetta
C
D001483:Base Sequence; D006147:Guanine / Q000737:chemistry*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*
D009838:Oligodeoxyribonucleotides; D006147:Guanine