Risk of laryngeal cancer by occupational chemical exposure in Turkey.
Laryngeal cancer is the second most common cancer among men in Turkey. In this hospital based case-control study, we evaluated laryngeal cancer risks from occupational chemical exposures. We analyzed 940 laryngeal cancer cases and 1519 controls. Occupational history, tobacco, and alcohol use and demographic information were obtained by a questionnaire. The job and industries were classified by special seven-digit codes. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) based on a developed exposure matrix for chemicals, including diesel exhaust, gasoline exhaust, polycyclic aromatic hydrocarbons (PAHs), formaldehyde, and solvents. An excess of laryngeal cancer occurred with diesel exhaust (OR=1.5, 95% CI=1.3-1.9), gasoline exhaust (OR=1.6, 95% CI=1.3-2.0), and PAHs (OR=1.3, 95% CI=1.1-1.6). There was a dose-response relationship for these substances with supraglottic cancers (P<0.000). The PAH association only occurred among those who also had exposure to diesel exhaust.
Elci
Omur Cinar
OC
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA. oae3@cdc.gov
Akpinar-Elci
Muge
M
Blair
Aaron
A
Dosemeci
Mustafa
M
D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects; D000428:Alcohol Drinking; D002274:Carcinogens, Environmental / Q000633:toxicity*; D016022:Case-Control Studies; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects; D007822:Laryngeal Neoplasms / Q000139:chemically induced / Q000453:epidemiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000453:epidemiology*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000145:classification; D009790:Occupations / Q000145:classification; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity; D018570:Risk Assessment / Q000379:methods; D012907:Smoking; D011795:Surveys and Questionnaires; D014421:Turkey / Q000453:epidemiology; D001335:Vehicle Emissions / Q000633:toxicity
D000395:Air Pollutants, Occupational; D002274:Carcinogens, Environmental; D011084:Polycyclic Aromatic Hydrocarbons; D001335:Vehicle Emissions