title: Fas (CD95/Apo-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology.
abstract: Members of the tumor necrosis factor (TNF) superfamily are crucially involved in the regulation of T cell activation, homeostasis and cytotoxicity. In particular, Fas ligand (FasL), expressed by activated T lymphocytes, induces cell-mediated cytotoxicity and may also be responsible for apoptotic suicide. Tight regulation of this death-inducing ligand is a prerequisite for proper immune defense and homeostasis. In this review, we will discuss various aspects of FasL regulation in cell-mediated cytotoxicity, immune homeostasis and the immunopathology of diseases.
authors.affiliation: Division of Immunopathology, Institute of Pathology, University of Bern, Murtenstrasse 31, P.O. Box 62, 3010 Bern, Switzerland. tbrunner@pathology.unibe.ch
authors.forename: Thomas
authors.initials: T
authors.lastname: Brunner
authors.forename: Christoph
authors.initials: C
authors.lastname: Wasem
authors.forename: Ralph
authors.initials: R
authors.lastname: Torgler
authors.forename: Igor
authors.initials: I
authors.lastname: Cima
authors.forename: Sabine
authors.initials: S
authors.lastname: Jakob
authors.forename: Nadia
authors.initials: N
authors.lastname: Corazza
mesh_terms: D000818:Animals; D003602:Cytotoxicity, Immunologic; D053222:Fas Ligand Protein; D006706:Homeostasis; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D014158:Transcription, Genetic / Q000235:genetics
chemical_list: C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins