Increased genome instability in aging yeast.
In the September 26 issue of Science, McMurray and Gottschling (2003) report that aged yeast cells display high rates of loss of heterozygosity. Furthermore, they show that this reflects an impaired ability to correctly detect and repair DNA double-strand breaks. These results provide insights into how aging can engender genomic instability in eukaryotic cells.
Gravel
Serge
S
The Wellcome Trust/Cancer Research, UK.
Jackson
Stephen P
SP
D016922:Cellular Senescence / Q000502:physiology*; D004249:DNA Damage; D004260:DNA Repair; D016678:Genome; D016681:Genome, Fungal; D019656:Loss of Heterozygosity; D012441:Saccharomyces cerevisiae / Q000235:genetics*