title: Oxygenation in a human tumor xenograft: manipulation through respiratory challenge and antibody-directed infarction.
abstract: We recently demonstrated the use of 19F NMR relaxometry of hexafluorobenzene to monitor regional tumor oxygen tension dynamics in rats. We have now extended the application to human tumors implanted in immunocompromised (SCID) mice. This has allowed us both to investigate dynamic response to respiratory challenge (carbogen) and to probe the mechanisms of a new anti-vascular therapy designed to produce tumor-specific infarction.
authors.affiliation: Department of Radiology, U.T. Southwestern Medical Center, Dallas, TX 75390, USA.
authors.forename: Ralph P
authors.initials: RP
authors.lastname: Mason
authors.forename: Anca
authors.initials: A
authors.lastname: Constantinescu
authors.forename: Sophia
authors.initials: S
authors.lastname: Ran
authors.forename: Philip E
authors.initials: PE
authors.lastname: Thorpe
mesh_terms: D000818:Animals; D005466:Fluorocarbons / Q000378:metabolism; D006689:Hodgkin Disease / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D014183:Transplantation, Heterologous
chemical_list: D005466:Fluorocarbons; C003005:hexafluorobenzene; D010100:Oxygen