[Morphofunctional organization of pancreatic secretory activity (a new paradigm)].
This is a review of physiological, morphological and clinical studies of pancreas secretion with the emphasis placed on pancreatic enzymes. It was established that different parts of the duodenal mucous coat have different chemosensory thresholds to the stimulators and inhibitors of pancreatic secretion. Secretory regions of the pancreas having a modular organization are also functionally different. The module is a set of pancreatic acinar and ductal cells (a secretory component), a system of ducts with their valve structures and a microdepository of secretion (a transport component) with control mechanisms specific for the module. Pancreatic secretion is a result of stimulation and inhibition of specialized secretory and transport modules.
Korot'ko
G F
GF
Russian Center of Functional Surgical Gastroenterology, Ministry of Health, Russian Federation, Krasnodar.
Voskanian
S E
SE
D000818:Animals; D001692:Biological Transport; D004386:Duodenum / Q000033:anatomy & histology / Q000502:physiology; D006801:Humans; D007413:Intestinal Mucosa / Q000033:anatomy & histology / Q000166:cytology; D010179:Pancreas / Q000033:anatomy & histology* / Q000201:enzymology / Q000378:metabolism*; D010183:Pancreatic Ducts / Q000166:cytology / Q000378:metabolism