Tetracyclines for treating multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia.
OBJECTIVE
To report the use of tetracyclines for the treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP).


METHODS
Observational case series.


METHODS
. The Presley Regional Trauma Center located within the Regional Medical Center, Memphis, Tennessee, USA.


METHODS
Seven critically ill trauma patients with VAP caused by A. baumannii isolates that were resistant to all antibiotics tested except for doxycycline or minocycline.


METHODS
Patients were treated with IV doxycycline or minocycline for an average of 13.5 (range 9-20) days.


RESULTS
Doxycycline or minocycline was successful in six of seven patients.


CONCLUSIONS
Doxycycline or minocycline may be effective for treating multidrug-resistant A. baumannii VAP.
Wood
G Christopher
GC
Department of Clinical Pharmacy, The University of Tennessee College of Pharmacy, 26 South Dunlap, Memphis, Tennessee 38163, USA. cwood@utmem.edu
Hanes
Scott D
SD
Boucher
Bradley A
BA
Croce
Martin A
MA
Fabian
Timothy C
TC
D018806:APACHE; D000151:Acinetobacter Infections / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D040981:Acinetobacter baumannii; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D003422:Critical Care / Q000379:methods; D016638:Critical Illness; D003428:Cross Infection / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D004318:Doxycycline / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D017053:Infection Control / Q000379:methods; D007262:Infusions, Intravenous; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use*; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D012121:Respiration, Artificial / Q000009:adverse effects*; D012189:Retrospective Studies; D013714:Tennessee / Q000453:epidemiology; D014193:Trauma Centers; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D008911:Minocycline; D004318:Doxycycline