Fluorinated peptide nucleic acid.
The fluorinated olefinic peptide nucleic acid analogue (F-OPA) monomer containing the base thymine was synthesised in 13 steps. PNAs containing this unit were prepared and their pairing properties assessed by means of UV-melting experiments.
Hollenstein
Marcel
M
Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland. hollenstein@ioc.unibe.ch
Gautschi
Daniel
D
Leumann
Christian J
CJ
D001483:Base Sequence; D005461:Fluorine; D007202:Indicators and Reagents; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D020135:Peptide Nucleic Acids; D005461:Fluorine