Angiopoietin-2 polymorphism in women with idiopathic recurrent miscarriage.
OBJECTIVE
To investigate the relationship between idiopathic recurrent miscarriage and a polymorphism of the gene encoding for angiopoietin-2 (ANGPT2), an autochthonous modulator of angiogenesis during pregnancy.


METHODS
Prospective case control study.


METHODS
Academic research institution.


METHODS
One hundred thirty-one women with a history of three or more consecutive pregnancy losses before 20 weeks' gestation, and 125 healthy, postmenopausal controls with at least two live births and no history of pregnancy loss.


METHODS
Peripheral venous puncture.


METHODS
Polymerase chain reaction and restriction fragment length polymorphism analysis were performed to identify the different ANGPT2 alleles.


RESULTS
No association between mutant (mt) allele and the occurrence of idiopathic recurrent miscarriage was found. Between women with primary and secondary idiopathic recurrent miscarriage, no statistically significant differences with respect to allele frequencies were observed.


CONCLUSIONS
This is the first report on the ANGPT2 gene polymorphism in women with idiopathic recurrent miscarriage, demonstrating that the investigated polymorphism is not associated with idiopathic recurrent miscarriage in a white population.
Pietrowski
Detlef
D
Department of Gynecology and Obstetrics, University of Freiburg School of Medicine, Freiburg, Germany. pietrowski@frk.ukl.uni-freiburg.de
Tempfer
Clemens
C
Bettendorf
Hertha
H
Bürkle
Bernd
B
Nagele
Fritz
F
Unfried
Gertrud
G
Keck
Christoph
C
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D000483:Alleles; D042702:Angiopoietin-2 / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D011446:Prospective Studies
D042702:Angiopoietin-2