Ribo-, xylo-, and arabino-configured adenine-based nucleoside phosphonates: synthesis of monomers for solid-phase oligonucleotide assembly.
Adenine-based, regioisomeric nucleoside phosphonates with ribo, xylo and arabino configuration were synthesized in the protected form suitable for the phosphotriester-like, solid-phase synthesis of oligonucleotides. Phosphonate moiety was protected by 4-methoxy-1-oxido-2-picolyl group and the furanose hydroxyl by the dimethoxytrityl group.
Páv
Ondrej
O
Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague, Czech Republic.
Budesínský
Milos
M
Rosenberg
Ivan
I
D000227:Adenine Nucleotides / Q000138:chemical synthesis*; D001089:Arabinose; D001483:Base Sequence; D007202:Indicators and Reagents; D015394:Molecular Structure; D009841:Oligonucleotides / Q000138:chemical synthesis*; D063065:Organophosphonates / Q000138:chemical synthesis*; D012266:Ribose; D013329:Structure-Activity Relationship; D014994:Xylose
D000227:Adenine Nucleotides; D007202:Indicators and Reagents; D009841:Oligonucleotides; D063065:Organophosphonates; D012266:Ribose; D014994:Xylose; D001089:Arabinose