Dosimetry for radiocolloid therapy of cystic craniopharyngiomas.
The dosimetry for radiocolloid therapy of cystic craniopharyngiomas is investigated. Analytical calculations based on the Loevinger and the Berger formulas for electrons and photons, respectively, are compared with Monte Carlo simulations. The role of the material of which the colloid introduced inside the craniopharyngioma is made of as well as that forming the cyst wall is analyzed. It is found that the analytical approaches provide a very good description of the simulated data in the conditions where they can be applied (i.e., in the case of a uniform and infinite homogeneous medium). However, the consideration of the different materials and interfaces produces a strong reduction of the dose delivered to the cyst wall in relation to that predicted by the Loevinger and the Berger formulas.
Rojas
E Leticia
EL
Departamento de Física Moderna, Universidad de Granada, E-18071 Granada, Spain.
Al-Dweri
Feras M O
FM
Lallena
Antonio M
AM
Bodineau
Coral
C
Galán
Pedro
P
D001610:Beta Particles / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000503:physiopathology / Q000532:radiotherapy; D002473:Cell Wall; D020863:Central Nervous System Cysts / Q000503:physiopathology / Q000532:radiotherapy*; D003102:Colloids / Q000032:analysis / Q000627:therapeutic use; D003198:Computer Simulation; D003397:Craniopharyngioma / Q000503:physiopathology / Q000532:radiotherapy*; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D009010:Monte Carlo Method; D010761:Phosphorus Radioisotopes / Q000032:analysis / Q000627:therapeutic use; D010911:Pituitary Neoplasms / Q000503:physiopathology / Q000532:radiotherapy*; D011868:Radioisotopes / Q000032:analysis / Q000627:therapeutic use; D011874:Radiometry / Q000379:methods*; D019275:Radiopharmaceuticals / Q000032:analysis* / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012062:Relative Biological Effectiveness; D015203:Reproducibility of Results; D012211:Rhenium / Q000032:analysis / Q000627:therapeutic use; D012680:Sensitivity and Specificity
D003102:Colloids; D010761:Phosphorus Radioisotopes; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012211:Rhenium