title: Stereotactic radiofrequency ablation for sessile hypothalamic hamartoma with an image fusion technique.
abstract: BACKGROUND
  Radiosurgery has been advocated as a primary treatment for hypothalamic hamartoma (HH), but it has a risk of damaging the surrounding structures and does not have an immediate effect for refractory epilepsy, endocrinological and mental disorders.
  
  
  METHODS
  We report on a 13-year-old boy with a large and sessile HH who presented with intractable seizures, precocious puberty and aggressiveness. Stereotactic radiofrequency ablation (SRA) combined with an image fusion technique was performed to make a maximum ablative lesion within the HH via multiple trajectories.
  
  
  RESULTS
  After surgery, we observed rapid cessation of the gelastic seizures and aggressiveness. The ophthalmological function did not get worse, and the hypothalamopituitary function improved.
  
  
  CONCLUSIONS
  SRA in combination with an image fusion technique is a viable alternative treatment for HH, because it provides precise preoperative simulation and immediate improvement of symptoms can be obtained.
authors.affiliation: Department of Neurosurgery, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: A
authors.initials: A
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Saitoh
authors.forename: H
authors.initials: H
authors.lastname: Ninomiya
authors.forename: K
authors.initials: K
authors.lastname: Imai
authors.forename: R I
authors.initials: RI
authors.lastname: Sakakibara
authors.forename: M
authors.initials: M
authors.lastname: Maruno
authors.forename: H
authors.initials: H
authors.lastname: Kishima
authors.forename: K
authors.initials: K
authors.lastname: Yoshimura
authors.forename: H
authors.initials: H
authors.lastname: Hasegawa
authors.forename: T
authors.initials: T
authors.lastname: Yoshimine
mesh_terms: D000293:Adolescent; D017115:Catheter Ablation / Q000379:methods*; D002560:Cerebrovascular Circulation / Q000502:physiology; D006222:Hamartoma / Q000150:complications* / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications* / Q000503:physiopathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D016634:Radiosurgery / Q000379:methods*; D012640:Seizures / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed