title: An industrial process for synthesizing Lodenosine (FddA).
abstract: Two industrial synthetic approaches to Lodenosine (1, FddA, 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl) adenine) via a purine riboside or a purine 3'-deoxyriboside are described. Several novel applications of deoxygenation and fluorination methods are compared considering reaction yields, economy, safety and environmental concerns.
authors.affiliation: AminoScience Laboratories, Ajinomoto Co., Inc., Kawasaki-ku, Kawasaki, Japan. kunisuke_izawa@ajinomoto.com
authors.forename: Kunisuke
authors.initials: K
authors.lastname: Izawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takamatsu
authors.forename: Satoshi
authors.initials: S
authors.lastname: Katayama
authors.forename: Naoko
authors.initials: N
authors.lastname: Hirose
authors.forename: Shigetaka
authors.initials: S
authors.lastname: Kozai
authors.forename: Tokumi
authors.initials: T
authors.lastname: Maruyama
mesh_terms: D016048:Dideoxyadenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry*; D004345:Drug Industry / Q000379:methods; D007202:Indicators and Reagents; D008968:Molecular Conformation
chemical_list: D007202:Indicators and Reagents; C073072:lodenosine; D016048:Dideoxyadenosine