A new tiazofurin pronucleotide: synthesis and biological evaluation of cyclosaligenyl-tiazofurin monophosphate.
Synthesis and biological activities of cyclosaligenyl-tiazofurin monophosphate (CycloSal-TRMP), a new tiazofurin pronucleotide, are reported. CycloSal-TRMP proved to be active in vitro against human myelogenous leukemia K562 cell line and as A1 adenosine receptor agonist.
Cappellacci
L
L
Department of Chemical Sciences, University of Camerino, Camerino, MC, Italy.
Barboni
G
G
Franchetti
P
P
Martini
C
C
Jayaram
H N
HN
Grifantini
M
M
D058916:Adenosine A1 Receptor Antagonists; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020014:K562 Cells; D010710:Phosphates / Q000138:chemical synthesis / Q000494:pharmacology; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
D058916:Adenosine A1 Receptor Antagonists; D000970:Antineoplastic Agents; D010710:Phosphates; D011355:Prodrugs; D012254:Ribavirin; C033706:tiazofurin