Sphingosine-1-phosphate signaling in endothelial activation.
The signaling and functions of the Endothelial Differentiation Gene (EDG) family of G protein-coupled receptors have been extensively elucidated. All the members of EDG family were shown to be receptors for lysosphingolipids or lysophospholipids. EDG-1, the prototype of EDG family receptors, is a high affinity receptor for serum-borne bioactive lipid, Sphingosine-1-phosphate (S1P). S1P, secreted by thrombotic platelets, has been shown to regulate a variety of cellular responses, including survival, cytoskeletal remodeling, chemotaxis etc, via the activation of cell surface EDG receptors. Recently, a novel function of S1P in modulating angiogenic response has been demonstrated. This review will focus on S1P/ EDG-1 signaling in endothelial activation, in particular in the S1P-mediated adherens junctions assembly and chemotaxis in endothelial cells.
Ozaki
Harunobu
H
Center for Vascular Biology, Department of Physiology, University of Connecticut Health Center, Farmington, CT 06030, USA.
Hla
Timothy
T
Lee
Menq-Jer
MJ
D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D017874:Immediate-Early Proteins / Q000502:physiology; D008246:Lysophospholipids; D018919:Neovascularization, Physiologic / Q000502:physiology; D015539:Platelet Activation / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D049312:Receptors, Lysophospholipid; D015398:Signal Transduction / Q000502:physiology*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000502:physiology*
D017874:Immediate-Early Proteins; D008246:Lysophospholipids; D043562:Receptors, G-Protein-Coupled; D049312:Receptors, Lysophospholipid; C060506:sphingosine 1-phosphate; D013110:Sphingosine