title: Synthesis and antiviral evaluation of beta-D- and beta-L-pentofuranonucleoside derivatives bearing 5-trifluoromethylcytosine as the base.
abstract: Beta-D- and beta-L-pentofuranonucleoside derivatives bearing 5-trifluoromethylcytosine as the base have been synthesized. The compounds were tested for their activity against HIV and HBV, but they did not show significant antiviral effect.
authors.affiliation: Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS, Université Montpellier II, Place Eugene Bataillon, Montpellier, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Marchand
authors.forename: Christophe
authors.initials: C
authors.lastname: Mathé
authors.forename: Gilles
authors.initials: G
authors.lastname: Gosselin
mesh_terms: D044503:5-Methylcytosine; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D009904:Optical Rotation; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D007202:Indicators and Reagents; D012263:Ribonucleosides; D044503:5-Methylcytosine