A critical examination of current HIV therapies.
This review critically examines the current methods of eliminating and preventing human immunodeficiency virus (HIV) infection. It illustrates both the experimental and practical limitations that each approach faces, and how they may be overcome. An overview of the HIV, including its structure and life cycle is presented. Subsequently, the two main methods of post-infection treatment, drug and gene therapy are outlined. The development of HIV vaccination is discussed with an analysis of conventional vaccination techniques leading into the novel approaches. The final option examined describes the potential for a combined vaccination regimen. Finally, the question of why these approaches have met with little success is addressed. This includes practical research limitations, as well as an examination of the qualities of HIV that make it so elusive.
Semple
J W
JW
Biology Department, University of Waterloo, ON, Canada. jwsemple@sciborg.uwaterloo.ca