title: [Tissue and blood oxygenation in newborns < 1250g and incidence of ROP].
abstract: OBJECTIVE
  The aim of this study was to analyze correlations between the onset and severity of retinopathy and premature birth.
  
  
  METHODS
  In the three groups of 30 newborns < 1250 g we have analyzed blood saturation, tissue oxygenation and blood transfusion. To estimate tissue oxygenation we used following formulas; 1. TVCE = [formula: see text] V-blood volume = 8% of body weight 2. Oxygen availability = (0.54 + 0.005 x gestational age) x Hb (g/dL) Additionally we investigated incidence of BPD, PDA, severe IVH, and sepsis.
  
  
  RESULTS
  We have found statistically significant influence of drops of SaO2 < 85% and lower mean values of SaO2 on development of severe retinopathy. We have not seen any statistical differences in the other parameters of oxygenation between the groups.
  
  
  CONCLUSIONS
  Fluctuation as well as instability of oxygen blood saturation seem to be the most important risk factors of retinopathy. Limitation of early blood transfusions can decrease incidence of ROP. We do not have adequate methods for the estimation of tissue oxygenation which can be used to verify indications for blood transfusion. We should use very restrictive recommendations for blood transfusion in ELBW babies.
authors.affiliation: Kliniki Neonatologii Akademii Medycznej w Warszawie.
authors.forename: M Katarzyna
authors.initials: MK
authors.lastname: Kornacka
authors.forename: Anna
authors.initials: A
authors.lastname: Tupieka
authors.forename: Izabella
authors.initials: I
authors.lastname: Czajka
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Gajewska
authors.forename: Ewa
authors.initials: E
authors.lastname: Gołebiewska
mesh_terms: D001803:Blood Transfusion; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight / Q000097:blood*; D008297:Male; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D012178:Retinopathy of Prematurity / Q000097:blood*; D012307:Risk Factors
chemical_list: D010100:Oxygen