title: Identification of epilepsy-related genes by gene expression profiling in the hippocampus of genetically epileptic rat.
abstract: Ihara epileptic rat (IER) is an animal model of temporal lobe epilepsy (TLE) with genetically programmed microdysgenesis in the hippocampal formation. The neuronal microdysgenesis is thought to be a cause for recurrent spontaneous seizures. To identify differentially expressed genes in the hippocampus of IER in comparison to control Wistar rat, we performed serial analysis of gene expression (SAGE). As many as 21 differentially expressed genes were identified.
authors.affiliation: Department of Biochemistry II, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-0042, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Arai
authors.forename: Shigeru
authors.initials: S
authors.lastname: Amano
authors.forename: Akihide
authors.initials: A
authors.lastname: Ryo
authors.forename: Akiyuki
authors.initials: A
authors.lastname: Hada
authors.forename: Toru
authors.initials: T
authors.lastname: Wakatsuki
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shuda
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kondoh
authors.forename: Mikio
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D016172:DNA Fingerprinting; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000235:genetics; D004833:Epilepsy, Temporal Lobe / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling / Q000379:methods; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006624:Hippocampus / Q000002:abnormalities / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics; D009421:Nervous System Malformations / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D051381:Rats; D011922:Rats, Mutant Strains; D015854:Up-Regulation / Q000235:genetics
chemical_list: D009419:Nerve Tissue Proteins; D012333:RNA, Messenger