The effects of ante- and postnatal hypoxia on the central nervous system and their correction with peptide hormones.
Ante- and postnatal hypoxia significantly worsened the postnatal development of animals. The posthypoxic behavioral model included hyperactivity and decreased learning ability, these being typical manifestations of attention deficit disorder. A peptide constellation prevented and significantly improved posthypoxic postnatal development and eliminated the majority of negative behavioral changes.
Maslova
M V
MV
Faculty of Biology, M. V. Lomonosov Moscow State University, Vorob'ev Heights, 119890 Moscow, Russia.
Maklakova
A S
AS
Sokolova
N A
NA
Ashmarin
I P
IP
Goncharenko
E N
EN
Krushinskaya
Ya V
YV
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism*; D004359:Drug Therapy, Combination; D004723:Endorphins / Q000008:administration & dosage / Q000378:metabolism; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000196:embryology* / Q000378:metabolism* / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000378:metabolism*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000378:metabolism
D004723:Endorphins; D018696:Neuroprotective Agents; D010446:Peptide Fragments; D013973:Thyrotropin-Releasing Hormone; C041128:beta-casomorphin 7; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone