[The correlation between the electroencephalogram findings and clinical manifestations of Creutzfeldt-Jakob disease].
OBJECTIVE
To investigate the correlation between the EEG findings and the clinical signs of Creutzfeldt-Jakob disease (CJD).


METHODS
Serial standard recording during different stage of disease was conducted among 13 patients with CJD, 10 males and 3 females, with the year of onset of 58.2 (49 approximately 65). The EEG findings were analyzed in combination of the clinical symptoms and signs.


RESULTS
12 of the 13 patients showed typical periodic sharp wave complexes (PSWCs), occurring after the onset of myoclonus and akinetic mutism in 8 patients, both after myoconus and before akinetic mutism in 2 cases, and just at the onset of akinetic mutism before or after the onset of myoclonus respectively in 2 cases. Different EEG features were observed in different stages of disease. Frontal intermittent rhythmic delta activity (FIRDA) and frontal intermittent rhythmic triphasic slow wave, which was replaced by PSWC later, were seen in 4 cases.


CONCLUSIONS
PSWC has a close association with myoclonus and akinetic mutism. The best time of EEG recording is when myoclonus and/or akinetic mutism happen. FIRDA and frontal intermittent rhythmic triphasic slow wave may be hint of the onset of PSWC.
Sun
He-Yang
HY
Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.
Liu
Xiu-Qin
XQ
Huang
Yan
Y
Wang
Ping
P
Cong
Bo
B
D000368:Aged; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged