title: Intracellular Ca2+ release and ischemic axon injury: the Trojan horse is back.
abstract: Ischemic injury of cells in the central nervous system is typically set in motion by influx of extracellular Ca(2+). In this issue of Neuron, Stys and colleagues propose that ischemic injury in spinal cord axons is partly the result of ryanodine receptor-mediated release of Ca(2+) from the endoplasmic reticulum (ER), a site of intracellular Ca(2+) storage.
authors.affiliation: Department of Neurology, University of Washington Medical School, Seattle, WA 98195, USA.
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Ransom
authors.forename: Angus M
authors.initials: AM
authors.lastname: Brown
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D015687:Cell Hypoxia / Q000502:physiology; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism*
chemical_list: D002118:Calcium