[Antioxidants in malignant neoplasms in humans and animals].
This review is devoted to the role of low molecular weight antioxidants and antioxidant enzymes in cancerogenesis. The data on accumulation of lipid-soluble and water-soluble antioxidants in a number of malignant human and experimental tumors especially in the renal cell carcinoma tissues are analyzed. A possibility is discussed concerning the pro- and anticarcinogenic effects of the abundant tumor content of antioxidants. Implication of antioxidants in tumor resistance to chemotherapeutic drugs and ionizing radiation is discussed.
Nikiforova
N V
NV
Institute of Urology, Ministry of Public Health Care of Russian Federation, 3-d Parkovaya Str. 51, 105425 Moscow, Russia.
Berman
A E
AE
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism*; D017209:Apoptosis; D006801:Humans; D015227:Lipid Peroxidation; D008970:Molecular Weight; D009369:Neoplasms / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology
D000975:Antioxidants