Polymorphisms of heme oxygenase-1 and bilirubin UDP-glucuronosyltransferase genes are not associated with Kawasaki disease susceptibility.
Kawasaki disease (KD) is a systemic vasculitis and occurs among Japanese children at a high incidence. Serum bilirubin and heme oxygenase-1 (HO-1) expression are known to play a significant role in the protection of vascular endothelial cells. Japanese have unique polymorphic distribution patterns of (TA)7 or G71R of the bilirubin UDP-glucuronosyltransferase (B-UGT) gene and of (GT)n repeats of the HO-1 gene. We investigated the relationship of KD susceptibility with these polymorphisms. There were no significant differences in the distribution of allele frequencies and genotypes of these polymorphisms between KD patients and controls. These polymorphisms are not associated with KD susceptibility.
Kanai
Masayo
M
Department of Pediatrics, Yamagata University School of Medicine, Yamagata 990-9585, Japan.
Tanabe
Saori
S
Okada
Masahiko
M
Suzuki
Hiroshi
H
Niki
Takao
T
Katsuura
Michihiko
M
Akiba
Tomoharu
T
Hayasaka
Kiyoshi
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004247:DNA / Q000097:blood / Q000737:chemistry / Q000235:genetics; D004252:DNA Mutational Analysis / Q000379:methods; D018900:Dinucleotide Repeats / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000209:etiology; D005838:Genotype; D014453:Glucuronosyltransferase / Q000235:genetics*; D006419:Heme Oxygenase (Decyclizing) / Q000235:genetics*; D051547:Heme Oxygenase-1; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007223:Infant; D007564:Japan; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D009080:Mucocutaneous Lymph Node Syndrome / Q000201:enzymology / Q000209:etiology* / Q000235:genetics; D020125:Mutation, Missense; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics
D008565:Membrane Proteins; D004247:DNA; C496541:HMOX1 protein, human; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1; D014453:Glucuronosyltransferase