Anti-HIV active petrosins from the marine sponge Petrosia similis.
A marine sponge Petrosia similis afforded two compounds which belongs to bis-quinolizidine alkaloids namely, petrosin (1) and petrosin-A (2), respectively. Petrosin (1) and petrosin-A (2) showed anti-HIV inhibition with IC(50) values of 41.3 and 52.9 microm respectively. MAGI cell assays indicated that the compounds inhibited early steps of HIV replication. In extracellular HIV-1 Reverse Transcriptase inhibition assay petrosin and petrosin-A inhibited HIV-1 RT at 10.6 and 14.8 microm. This is the first report of petroisns with anti-HIV activity.
Venkateshwar Goud
Thirumani
T
Natural Products Laboratory, Organic Chemistry Division-I, Indian Institute of Chemical Technology, India.
Srinivasa Reddy
Natala
N
Raghavendra Swamy
Navath
N
Siva Ram
Tejomoortula
T
Venkateswarlu
Yenamandra
Y
D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006367:HeLa Cells; D006801:Humans; D011161:Porifera
D019380:Anti-HIV Agents