title: Inhibition of gene expression by peptide nucleic acids in cultured cells.
abstract: We have tested in cultured cells the capacity of antisense and antigene PNAs to inhibit, in a sequence specific manner, the expression of oncogenes in leukaemia and pancreatic carcinoma cells. The results observed appeared promising and suggest that PNA may play in the future an important role in targeting disease-related genes.
authors.affiliation: Department of Biochemical Sciences and Technologies, Udine, Italy.
authors.forename: Susanna
authors.initials: S
authors.lastname: Cogoi
authors.forename: Valentina
authors.initials: V
authors.lastname: Rapozzi
authors.forename: Luigi E
authors.initials: LE
authors.lastname: Xodo
mesh_terms: D000818:Animals; D001483:Base Sequence; D001692:Biological Transport; D002460:Cell Line; D003062:Codon / Q000235:genetics; D005786:Gene Expression Regulation / Q000187:drug effects*; D011905:Genes, ras / Q000187:drug effects; D006801:Humans; D020319:Oligodeoxyribonucleotides, Antisense / Q000493:pharmacokinetics / Q000494:pharmacology; D020135:Peptide Nucleic Acids / Q000493:pharmacokinetics / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014407:Tumor Cells, Cultured
chemical_list: D003062:Codon; D020319:Oligodeoxyribonucleotides, Antisense; D020135:Peptide Nucleic Acids; D012333:RNA, Messenger