Is intracytoplasmic sperm injection safe?
OBJECTIVE
To review the pregnancy and birth outcomes of patients undergoing intracytoplasmic sperm injection (ICSI).


METHODS
Selective review of the literature.


METHODS
Couples undergoing either conventional IVF or ICSI and their resulting offspring.


METHODS
None.


METHODS
None.


METHODS
None.


RESULTS
These observational studies are unfortunately inherently biased. Regardless, the information and experiences from these large centers cannot be ignored. These experiences reveal that birth weight may be decreased by an amount that is generally not clinically relevant. Chromosomal and genetic abnormalities are increased probably only as a direct corollary to the underlying parental risk. Congenital malformations reveal no clustering of any single specific abnormality. Developmental assessment is available for up to 2 years, and no major delays have been identified in either motor or mental function.


CONCLUSIONS
Intracytoplasmic sperm injection appears to be a safe alternative for couples who otherwise would be unable to achieve pregnancy. The inherent risks associated with these genetically "at risk" couples mandate thorough evaluation and counseling before undertaking ICSI.
Retzloff
Matthew G
MG
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Hornstein
Mark D
MD
D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000706:statistics & numerical data; D000013:Congenital Abnormalities / Q000453:epidemiology; D002658:Developmental Disabilities / Q000453:epidemiology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects*