title: Purine derivatives of 1,2-disubstituted cyclohexane analogues of nucleosides.
abstract: Starting from (+/-)-cis-2-hydroxymethylcyclohexylamine, a series of cyclohexane-derived cis-1,2-disubstituted carbonucleoside analogues with a 6- or 2,6-purine or 8-azapurine base were synthesized. The antiviral and antitumoral in vitro effects of the new compounds were evaluated.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Vigo, Vigo, Pontevedra, Spain. mcteran@uvigo.es
authors.forename: C
authors.initials: C
authors.lastname: Terán
authors.forename: L
authors.initials: L
authors.lastname: Santana
authors.forename: E
authors.initials: E
authors.lastname: Uriarte
authors.forename: D
authors.initials: D
authors.lastname: Viña
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003510:Cyclohexanes; D015195:Drug Design; D006801:Humans; D051379:Mice; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D003510:Cyclohexanes; D011687:Purines