A survey on uncertainty in bioassay measurements carried out within the OMINEX project.
One of the topics covered by the OMINEX (Optimisation of Monitoring for Internal Exposure) project was to look at the bioassay measurements performed in the European laboratories. Questionnaires on bioassay measurements by alpha spectrometry or inductively coupled plasma-mass spectrometry (ICP-MS) were sent to European laboratories. The main objective was to collect information on analytical procedures and on the uncertainties associated with bioassay results. Alpha spectrometry is the technique most often used for the determination of alpha emitters, such as actinides in biological samples. ICP-MS is not used much as yet for routine measurements of actinides in biological samples, but is very sensitive for measurements of long-lived radionuclides. The different parameters influencing the uncertainties on the results and the minimum detectable amount have been investigated. Optimum conditions for achieving low result uncertainties and high sensitivity are given for alpha spectrometry and ICP-MS.
Hurtgen
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SCK-CEN, Low Level Radioactivity Department, Boeretang 200, B-2400 Mol, Belgium. churtgen@sckcen.be
Cossonnet
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D000512:Alpha Particles; D003625:Data Collection; D005062:European Union; D005243:Feces / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods* / Q000706:statistics & numerical data; D011829:Radiation Dosage; D011868:Radioisotopes / Q000032:analysis*; D011874:Radiometry / Q000379:methods* / Q000706:statistics & numerical data*; D015203:Reproducibility of Results; D018401:Sample Size; D012680:Sensitivity and Specificity; D016482:Urinalysis / Q000379:methods* / Q000706:statistics & numerical data
D011868:Radioisotopes