Infants born to mothers with severe acute respiratory syndrome.
Severe acute respiratory syndrome (SARS) is a newly discovered infectious disease caused by a novel coronavirus. During the community outbreak in Hong Kong, 5 liveborn infants were born to pregnant women with SARS. A systematic search for perinatal transmission of the SARS-associated coronavirus, including serial reverse transcriptase-polymerase chain reaction assays, viral cultures, and paired serologic titers, failed to detect the virus in any of the infants. In addition, none of the infants developed clinical, radiologic, hematologic, or biochemical evidence suggestive of SARS. One preterm infant developed jejunal perforation and another developed necrotizing enterocolitis with ileal perforation shortly after birth. This case series is the first report to describe the clinical course of the first cohort of liveborn infants born to pregnant women with SARS.
Shek
Chi C
CC
Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Lai Chi Kok, New Territories, Hong Kong.
Ng
Pak C
PC
Fung
Genevieve P G
GP
Cheng
Frankie W T
FW
Chan
Paul K S
PK
Peiris
Malik J S
MJ
Lee
Kim H
KH
Wong
Shell F
SF
Cheung
Hon M
HM
Li
Albert M
AM
Hon
Ellis K L
EK
Yeung
Chung K
CK
Chow
Chun B
CB
Tam
John S
JS
Chiu
Man C
MC
Fok
Tai F
TF
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use; D002585:Cesarean Section; D015331:Cohort Studies; D004196:Disease Outbreaks; D020345:Enterocolitis, Necrotizing / Q000209:etiology; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D007077:Ileal Diseases / Q000209:etiology; D007231:Infant, Newborn; D007234:Infant, Premature; D018445:Infectious Disease Transmission, Vertical; D007416:Intestinal Perforation / Q000209:etiology; D007579:Jejunal Diseases / Q000209:etiology; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects / Q000627:therapeutic use; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology*; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications; D012254:Ribavirin / Q000009:adverse effects / Q000627:therapeutic use; D045473:Severe acute respiratory syndrome-related coronavirus / Q000302:isolation & purification; D045169:Severe Acute Respiratory Syndrome / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission*
D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D012254:Ribavirin; D008775:Methylprednisolone