Identification of epilepsy-related genes by gene expression profiling in the hippocampus of genetically epileptic rat.
Ihara epileptic rat (IER) is an animal model of temporal lobe epilepsy (TLE) with genetically programmed microdysgenesis in the hippocampal formation. The neuronal microdysgenesis is thought to be a cause for recurrent spontaneous seizures. To identify differentially expressed genes in the hippocampus of IER in comparison to control Wistar rat, we performed serial analysis of gene expression (SAGE). As many as 21 differentially expressed genes were identified.
Arai
Masaaki
M
Department of Biochemistry II, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-0042, Japan.
Amano
Shigeru
S
Ryo
Akihide
A
Hada
Akiyuki
A
Wakatsuki
Toru
T
Shuda
Masahiro
M
Kondoh
Nobuo
N
Yamamoto
Mikio
M
D000818:Animals; D016172:DNA Fingerprinting; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000235:genetics; D004833:Epilepsy, Temporal Lobe / Q000235:genetics* / Q000378:metabolism; D020869:Gene Expression Profiling / Q000379:methods; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006624:Hippocampus / Q000002:abnormalities / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics; D009421:Nervous System Malformations / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D051381:Rats; D011922:Rats, Mutant Strains; D015854:Up-Regulation / Q000235:genetics
D009419:Nerve Tissue Proteins; D012333:RNA, Messenger