title: Synthesis of oligonucleotide building blocks of 2'-deoxyguanosine bearing a C8-arylamine modification.
abstract: C8-Arylamine-dG adducts were synthesized by palladium-catalyzed cross-coupling reactions. The corresponding 5'-O-DMTr-3'-O-phosphoramidite-C8-arylamine-dG adducts were synthesized as potential building blocks for the automated synthesis of site-specifically modified oligonucleotides.
authors.affiliation: Institute of Organic Chemistry, University of Hamburg, Hamburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Gräsl
authors.forename: C
authors.initials: C
authors.lastname: Meier
mesh_terms: D002273:Carcinogens / Q000737:chemistry; D018360:Crystallography, X-Ray; D003849:Deoxyguanosine / Q000031:analogs & derivatives*; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D009841:Oligonucleotides / Q000138:chemical synthesis*; D010165:Palladium
chemical_list: D002273:Carcinogens; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D010165:Palladium; D003849:Deoxyguanosine