Alpha-LNA (alpha-D-configured locked nucleic acid).
Two pyrimidine alpha-LNA nucleoside monomers have been synthesised and incorporated into alpha-configured oligonucleotides. A fully modified mixed alpha-LNA sequence displays unprecedented parallel stranded hybridisation with complementary RNA and a remarkable selectivity for RNA over DNA. Modelling shows alpha-LNA:RNA to form an extended duplex with a very broad major groove.
Christensen
Nanna K
NK
Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark.
Petersen
Michael
M
Vester
Birte
B
Nielsen
Poul
P
D001483:Base Sequence; D004247:DNA / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense / Q000737:chemistry*; D011743:Pyrimidines; D012313:RNA / Q000737:chemistry*
D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; D011743:Pyrimidines; C477371:locked nucleic acid; D012313:RNA; D004247:DNA