[The distribution of angiotensin converting enzyme gene I/D polymorphism and its relationship with essential hypertension].
OBJECTIVE
To observe the distribution character of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in Chinese population and its relationship with essential hypertension.


METHODS
Polymerase chain reaction (PCR) technique was used to detect the angiotensin converting enzyme gene I/D polymorphism in 2966 subjects of Kailuan Coal Mine, and further restriction analysis was performed.


RESULTS
The frequencies of ACE II, ID, DD genotypes in total study population were 41.5%, 38.4%, 20.1%, respectively. The DD genotypes in hypertensive group and that in control group were 18.9% and 21.0%, respectively. There was no significant difference between hypertensive group and control group (P>0.05). The same result was seen after stratification by age and gender in each group, respectively(P>0.05). The DD genotype and D allele showed a tendency to decrease with the increase of age (P<0.001).


CONCLUSIONS
The above results suggested that essential hypertension was not associated with ACE I/D polymorphism. The distributions of ACE genotype and allele varied with age, and the subjects with the character of DD genotype were at higher risk of early death.
Zhang
Qi
Q
Department of Cardiology, Affiliated Kailuan Hospital, North China Coal Medical College, Tangshan, Hebei, 063000 PR China. vitaminc@sina.com
Shen
Zhi-xia
ZX
Li
Hong-fen
HF
Cheng
Ai-bin
AB
Hou
Qiu-xia
QX
Wu
Shou-ling
SL
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012737:Sex Factors
D007703:Peptidyl-Dipeptidase A