title: Polydimethylsiloxane versus polytetrafluoroethylene for vocal fold medialization: histologic evaluation in a rabbit model.
abstract: The objective is to study the tissue reaction of the paralyzed vocal cord in response to the injection of particulate plastics in a rabbit model. Forty-five New Zealand rabbits with surgical vocal-fold paralysis were used in the study. Histologic reactions of the larynx and the regional lymph nodes were analyzed by a single blinded pathologist at 6 weeks and 6 months after a vocal-cord injection of Teflon or of silicone elastomer. Macroscopic studies of the liver, lungs, spleen, kidney, and brain were performed. The histological study showed a greater proportion of chronic granulomatous inflammation in animals injected with silicone than in those injected with Teflon. The immunohistochemical study showed a higher degree of phagocytosis of Teflon particles than of the silicone particles. The silicone group presented a more severe fibrous reaction than the Teflon group, but the difference was not significant. No migration particles were found. It is concluded that silicone, having a greater viscosity than Teflon because of the size of its particles, induces more fibrosis and a larger proportion of foreign giant cells in the host. Due to this histological reaction, silicone particles present greater anchorage and stability.
authors.affiliation: Department of Otorhinolaryngology, Hospital Clínic of Barcelona, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Caballero
authors.forename: Manuel
authors.initials: M
authors.lastname: Bernal-Sprekelsen
authors.forename: Carlos
authors.initials: C
authors.lastname: Calvo
authors.forename: Xavier
authors.initials: X
authors.lastname: Farrè
authors.forename: Lorenc
authors.initials: L
authors.lastname: Quintó
authors.forename: Lucia
authors.initials: L
authors.lastname: Alòs
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism; D004129:Dimethylpolysiloxanes / Q000378:metabolism*; D005548:Foreign-Body Migration; D005549:Foreign-Body Reaction; D008422:Materials Testing; D011138:Polytetrafluoroethylene / Q000378:metabolism*; D011446:Prospective Studies; D019736:Prostheses and Implants; D019919:Prosthesis Implantation; D011817:Rabbits; D012826:Silicone Elastomers / Q000378:metabolism; D014826:Vocal Cord Paralysis / Q000628:therapy*; D014827:Vocal Cords / Q000166:cytology / Q000294:innervation / Q000378:metabolism / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D012826:Silicone Elastomers; D011138:Polytetrafluoroethylene