title: Macrophages in inflammatory bowel disease.
abstract: Blood monocytes which differentiate into tissue macrophages, are unique in that they can not only initiate immune responses but can also be effector cells which contribute to the resolution of these responses. There is no single activation phenotype, and macrophages can be induced to differentiate into cells that either exacerbate or inhibit acute inflammation. Similarly, these cells can promote, deviate or suppress adaptive immune responses. This review focuses on the mechanisms that have been implicated in the recruitment, activation and differentiation of inflammatory monocytes/macrophages in chronic inflammatory bowel diseases, i.e. ulcerative colitis and Crohn's disease. These mechanisms might provide attractive targets for novel therapies.
authors.affiliation: Gastroenterology and Hepatology Division, Department of Medicine, Malmö University Hospital, Lund University, S-20502 Malmö, Sweden. olof.grip@medforsk.mas.lu.se
authors.forename: Olof
authors.initials: O
authors.lastname: Grip
authors.forename: Sabina
authors.initials: S
authors.lastname: Janciauskiene
authors.forename: Stefan
authors.initials: S
authors.lastname: Lindgren
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000473:pathology*; D008262:Macrophage Activation / Q000502:physiology; D008264:Macrophages / Q000473:pathology*; D009000:Monocytes / Q000473:pathology