Downstream of guidance receptors: entering the baroque period of axon guidance signaling.
The Roundabout ("Robo") family of transmembrane proteins are the receptors and mediators of the repellent axon guidance signal Slit. However, the molecular mechanisms by which Robo signaling leads to growth cone or neuron repulsion are still poorly understood. A study by Fan et al. in this issue of Neuron expands the repertoire of Robo pathway components and stimulates a new look at axon guidance signaling in general.
Schmucker
Dietmar
D
Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
D000818:Animals; D001369:Axons / Q000502:physiology*; D006801:Humans; D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D000097905:Roundabout Proteins
D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic; D000097905:Roundabout Proteins