title: Presacral multiple cellular schwannomas.
abstract: METHODS
  Case report. The authors documented a patient presenting with multiple cellular schwannomas along the sciatic nerve. The patient had no stigmas of neurofibromatosis. Thirteen tumors were resected via both anterior and posterior approaches.
  
  
  OBJECTIVE
  To point out that presacral cellular schwannoma can display multiple occurrences.
  
  
  BACKGROUND
  Cellular schwannoma, which is a well-recognized variant of benign schwannoma, is often misdiagnosed as sarcoma. The tumor is usually a solitary lesion.
  
  
  METHODS
  Medical history, physical findings, imaging features, and histologic findings were reviewed in a case of multiple cellular schwannomas in the presacral regions.
  
  
  RESULTS
  A 39-year-old woman without any evidence of neurofibromatosis underwent removal of presacral multiple tumors along the sacral nerve root. Nineteen years after the surgery, the tumors recurred with multiple fashion. Thirteen tumors were resected via both anterior and posterior approaches. Immunohistochemical analysis of S-100 protein and Ki-67 were beneficial with respect to differentiation of cellular schwannoma from malignant peripheral nerve sheath tumor.
  
  
  CONCLUSIONS
  The present case illustrated that multiple cellular schwannomas can develop in nonneurofibromatosis patients.
authors.affiliation: Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Course for Biological Functions and Medical Control, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan. aogose@med.niigata-u.ac.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Ogose
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Hotta
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hatano
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawashima
authors.forename: Hajime
authors.initials: H
authors.lastname: Umezu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Higuchi
authors.forename: Naoto
authors.initials: N
authors.lastname: Endo
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008279:Magnetic Resonance Imaging; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D009442:Neurilemmoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009418:S100 Proteins / Q000032:analysis; D012447:Sacrum; D013125:Spinal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome; D014746:Vimentin / Q000032:analysis
chemical_list: D019394:Ki-67 Antigen; D009418:S100 Proteins; D014746:Vimentin