The aging spine: new technologies and therapeutics for the osteoporotic spine.
Osteoporosis results in low-energy fractures of the spine. The load necessary to cause a vertebral fracture is determined by the characteristics related to the vertebral body structure, mineral content, and quality of bone. Radiographic techniques centered on dual X-ray absorptiometry (DXA) permit a determination of bone mass and fracture risk. Current medical therapies principally using bisphosphonate and pulsatile PTH profoundly decrease the risk of fracture (50+%). Fall prevention strategies can further decrease the possibility of fracture. A comprehensive approach to osteoporosis can favorably alter the disease.
Lane
Joseph M
JM
Metabolic Bone Disease Service, Hospital for Special Surgery, New York, New York, USA. lanej@hss.edu
Gardner
Michael J
MJ
Lin
Julie T
JT
van der Meulen
Marjolein C
MC
Myers
Elizabeth
E
D015502:Absorptiometry, Photon; D000058:Accidental Falls; D000368:Aged; D000375:Aging / Q000473:pathology*; D001696:Biomechanical Phenomena; D002116:Calcitonin / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use; D006801:Humans; D010024:Osteoporosis / Q000150:complications* / Q000188:drug therapy; D010281:Parathyroid Hormone; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use; D016103:Spinal Fractures / Q000000981:diagnostic imaging / Q000209:etiology* / Q000517:prevention & control
D004164:Diphosphonates; D010281:Parathyroid Hormone; D020845:Selective Estrogen Receptor Modulators; D002116:Calcitonin