Anti-platelet aggregation and chemical constituents from the rhizome of Gynura japonica.
A novel quinonoid terpenoid, (-)- alpha-tocospirone, a new chromanone, (-)-gynuraone, as well as three new steroids, (22 E,24 S)-7 alpha-hydroperoxystigmasta-5,22-dien-3 beta-ol, (22 E,24 S)-stigmasta-1,4,22-trien-3-one, and (24 R)-stigmasta-1,4-dien-3-one, together with 15 known components, were isolated from the rhizome of Formosan Gynura japonica. Structures of the new compounds were determined through spectral analyses and chemical evidence. Several of the isolated compounds, caryophyllene oxide, 6-acetyl-2,2-dimethylchroman-4-one, vanillin, 2,6-dimethoxy-1,4-benzoquinone, and benzoic acid exhibited significant anti-platelet aggregation activity in vitro.
Lin
Wei-Yu
WY
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan, Republic of China.
Kuo
Yueh-Hsiung
YH
Chang
Ya-Ling
YL
Teng
Che-Ming
CM
Wang
Eng-Chi
EC
Ishikawa
Tsutomu
T
Chen
Ih-Sheng
IS
D000818:Animals; D008517:Phytotherapy; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011817:Rabbits; D012674:Senecio; D013729:Terpenes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D010938:Plant Oils; D010975:Platelet Aggregation Inhibitors; D013729:Terpenes