4'-C-methyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides revisited.
In order to evaluate their antiviral properties, a series of 4'-C-methyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides has been prepared. Unfortunately, none of these 4'-branched nucleosides showed any antiviral activity or cytotoxcity when tested against HIV, HBV, and Yellow Fever virus.
Griffon
J F
JF
Laboratoire Coopératif Idenix-CNRS, Université Montpellier II, France.
Dukhan
D
D
Pierra
C
C
Benzaria
S
S
Loi
A G
AG
La Colla
P
P
Sommadossi
J P
JP
Gosselin
G
G
D000998:Antiviral Agents / Q000138:chemical synthesis; D015195:Drug Design; D007202:Indicators and Reagents; D008745:Methylation; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D012266:Ribose
D000998:Antiviral Agents; D007202:Indicators and Reagents; D011684:Purine Nucleosides; D011741:Pyrimidine Nucleosides; D012266:Ribose