Myoblasts fuse when loner meets ARF6.
Studies of myoblast fusion in Drosophila have revealed numerous signaling and structural proteins that regulate this critical event in muscle development. A paper by Chen et al. published in the September 19 issue of Cell adds ARF6, a GTPase, and one of its guanine nucleotide exchange factors to this set of players.
Donaldson
Julie G
JG
Laboratory of Cell Biology, NHLBI, NIH, Building 50, Room 2503, Bethesda, MD 20892, USA.
D000089982:ADP-Ribosylation Factor 6; D020727:ADP-Ribosylation Factors / Q000502:physiology*; D000818:Animals; D002459:Cell Fusion; D004330:Drosophila; D009132:Muscles / Q000166:cytology*; D032446:Myoblasts / Q000502:physiology*; D015398:Signal Transduction
D000089982:ADP-Ribosylation Factor 6; D020727:ADP-Ribosylation Factors