Antioxidant properties of captopril in vitro.
This paper reports on the effect of captopril on the stability of unsaturated fatty acids in the evening primrose oil. The experiment was performed for captopril at concentrations of 0.05%, 0.1% and 0.2% in the samples of evening primrose oil at temperatures of 20 degrees, 40 degrees and 60 degrees C. The determination was performed on the 10th day of incubation. The results were compared to those obtained for analogous samples with octyl gallate, an antioxidant commonly used in oil systems, taken at the same concentrations and at the same temperatures. The changes in concentrations of the substances studied with time were monitored by gas chromatography. The results have shown captopril to be a stronger antioxidant than octyl gallate at all concentrations and temperatures used.
Radomska
Anna
A
Department of Pharmaceutical Technology, Faculty of Pharmacy, K. Marcinkowski University of Medical Sciences, 6 Grunwaldzka Str., 60-780 Poznań, Poland.
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry*; D000975:Antioxidants / Q000737:chemistry*; D002216:Captopril / Q000737:chemistry*; D002849:Chromatography, Gas; D004952:Esters / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry; D005228:Fatty Acids, Essential / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D008041:Linoleic Acids; D031665:Oenothera biennis; D010938:Plant Oils; D017965:gamma-Linolenic Acid
D000806:Angiotensin-Converting Enzyme Inhibitors; D000975:Antioxidants; D004952:Esters; D005227:Fatty Acids; D005228:Fatty Acids, Essential; D005609:Free Radicals; D008041:Linoleic Acids; D010938:Plant Oils; C016627:octyl gallate; C028498:evening primrose oil; D005707:Gallic Acid; D017965:gamma-Linolenic Acid; D002216:Captopril