title: Stress management: MHC class I and class I-like molecules as reporters of cellular stress.
abstract: The evolutionarily ancient intracellular stress response protects cells from the effects of external and internal forces which perturb cellular metabolism. Members of the major histocompatibility complex (MHC) class I-like superfamily act as cell surface indicators of the intracellular stress response. Cellular immunity employs these indicators as a cue for elimination of damaged, infected, and malignant cells, promoting the health of the individual and the evolutionary success of the species.
authors.affiliation: Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Gleimer
authors.forename: Peter
authors.initials: P
authors.lastname: Parham
mesh_terms: D000818:Animals; D015415:Biomarkers; D018834:Chaperonin 60 / Q000378:metabolism; D019143:Evolution, Molecular; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051379:Mice; D005810:Multigene Family; D011971:Receptors, Immunologic / Q000378:metabolism; D055607:Receptors, Natural Killer Cell; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
chemical_list: D015415:Biomarkers; D018834:Chaperonin 60; D015395:Histocompatibility Antigens Class I; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell