Social and psychosocial influences on inflammatory markers and vascular function in civil servants (the Whitehall II study).
Social position and psychosocial factors are associated with coronary disease, but the underlying pathophysiologic mechanisms remain unclear. In a sample of 283 nonsmokers, we found that social position was inversely associated with interleukin-6 and C-reactive protein and that participants with mild depression had impaired endothelial function.
Hemingway
Harry
H
International Centre for Health and Society, Department of Epidemiology and Public Health, University College London Medical School, London, United Kingdom. h.hemingway@public-health.ucl.ac.uk
Shipley
Martin
M
Mullen
Michael J
MJ
Kumari
Meena
M
Brunner
Eric
E
Taylor
Mia
M
Donald
Ann E
AE
Deanfield
John E
JE
Marmot
Michael
M
D001786:Blood Glucose / Q000032:analysis; D001824:Body Constitution; D002097:C-Reactive Protein / Q000032:analysis*; D003327:Coronary Disease / Q000453:epidemiology* / Q000523:psychology; D003863:Depression / Q000150:complications; D004651:Employment; D005215:Fasting; D005260:Female; D006801:Humans; D007328:Insulin / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D012923:Social Class; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000032:analysis; D006113:United Kingdom / Q000453:epidemiology
D001786:Blood Glucose; D007328:Insulin; D015850:Interleukin-6; D014280:Triglycerides; D002097:C-Reactive Protein