[Cardiac effects of fenibut in development of experimental chronic renal insufficiency].
The effect of fenibut on the mechanical activity of myocardium was studied in vitro and in vivo in rats with experimental chronic renal insufficiency (CRI) in a regime of physiologically alternating load simulating the intact heart function. The administration of fenibut (10 mg/kg) in rats after nephrectomy prevents the development of myocardial hyperfunction (characteristic of the animals with CRI in stage 1). In in vitro experiments on isolated myocardium fenibut also decreased the myocardial hyperfunction and reduced contractility to a control level, which was accompanied by accelerated relaxation in all finite systolic lengths.
Smirnov
A V
AV
St. Petersburg State Medical University, ul. L. Tolstogo 17, St. Petersburg, 197089 Russia.
Barabanova
T A
TA
Penchul
N A
NA
D000818:Animals; D066298:In Vitro Techniques; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
D005680:gamma-Aminobutyric Acid; C008842:4-amino-3-phenylbutyric acid