title: A general synthesis of 1-aryl carbamoyl-2-alkyl-4-aryl substituted semicarbazides as nonbasic factor Xa inhibitors.
abstract: An efficient four-step synthesis of 1-aryl-carbamoyl-2-alkyl-4-aryl-semicarbazides starting from benzophenone hydrazone is described leading to moderately active neutral factor Xa inhibitors.
authors.affiliation: Merck KGaA, Preclinical Pharmaceutical Research, 64271 Darmstadt, Germany. mederski@merck.de
authors.forename: Werner W K R
authors.initials: WW
authors.lastname: Mederski
authors.forename: Martina
authors.initials: M
authors.lastname: Germann
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology*; D065427:Factor Xa Inhibitors; D008968:Molecular Conformation; D012663:Semicarbazides / Q000138:chemical synthesis* / Q000494:pharmacology*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000473:Alkanes; D002219:Carbamates; D065427:Factor Xa Inhibitors; D012663:Semicarbazides; D015842:Serine Proteinase Inhibitors