title: Reactivity models of 1-N-vinyluracil and synthesis of a new class of potential antiviral agents by the use of 1,3-dipolar cycloaddition reactions.
abstract: By the use of a convergent approach based on 1,3-dipolar cycloaddition reactions between N-protected formylnitrones generated in situ and 1-N-vinyluracil, a new class of 4'-aza-analogues of 2',3'-dideoxynucleosides is synthesized. Competitive reaction for the endocyclic bond of uracil also brings to a new isoxazolidine derivative fused with the pyrimidine nucleus.
authors.affiliation: Dipartimento di Chimica, Università della Calabria, Arcavacata di Rende, (CS), Italy. eveline.colacino@mailcity.com
authors.forename: E
authors.initials: E
authors.lastname: Colacino
authors.forename: G
authors.initials: G
authors.lastname: De Luca
authors.forename: A
authors.initials: A
authors.lastname: Liguori
authors.forename: A
authors.initials: A
authors.lastname: Napoli
authors.forename: C
authors.initials: C
authors.lastname: Siciliano
authors.forename: G
authors.initials: G
authors.lastname: Sindona
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis*; D002625:Chemistry, Organic / Q000379:methods; D015195:Drug Design; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D014753:Vinyl Compounds / Q000138:chemical synthesis
chemical_list: D000998:Antiviral Agents; D007202:Indicators and Reagents; D014753:Vinyl Compounds; D014498:Uracil