title: Heart rate variability in patients with rheumatoid arthritis.
abstract: Heart rate variability (HRV) is a useful tool for the detection of sympathetic-parasympathetic balance in the autonomic nervous system. Autonomic nervous system involvement in patients with rheumatoid arthritis (RA) has rarely been studied and has shown conflicting results. Our purpose was to determine if HRV showed changes in patients with RA in comparison with the normal population. Short-term analysis of HRV was performed for time-domain frequency in 42 patients with RA and 44 matched controls. In this analysis, patients displayed lower standard deviation of the mean than healthy subjects ( P<0.0001). Patients tended to display higher pNN50 and root-mean-square of successive difference values than did healthy subjects, but these differences were not statistically significant (P >0.05). In frequency domain analysis, the spectral measures of HRV showed reduced high-frequency (HF) values and an higher low-frequency (LF) values; as a result, the ratio between low and high frequencies (LF/HF), representative of sympathovagal modulation, was significantly increased (P=0.001, P=0.012, and P=0.003, respectively). Our data suggest an increase in sympathetic control of the heart rate in patients with RA. This increased sympathetic activity could play a key role in the development of ventricular tachyarrhythmias in RA and may be related to the higher incidence of sudden death in this disorder.
authors.affiliation: Department of Cardiology, Pamukkale University School of Medicine, Denizli, Turkey. harunevrengul@hotmail.com
authors.forename: Harun
authors.initials: H
authors.lastname: Evrengül
authors.forename: Dursun
authors.initials: D
authors.lastname: Dursunoglu
authors.forename: Veli
authors.initials: V
authors.lastname: Cobankara
authors.forename: Bülent
authors.initials: B
authors.lastname: Polat
authors.forename: Deniz
authors.initials: D
authors.lastname: Seleci
authors.forename: Sibel
authors.initials: S
authors.lastname: Kabukçu
authors.forename: Asuman
authors.initials: A
authors.lastname: Kaftan
authors.forename: Ender
authors.initials: E
authors.lastname: Semiz
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kilic
mesh_terms: D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000503:physiopathology; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000503:physiopathology; D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010275:Parasympathetic Nervous System / Q000503:physiopathology