The P2Y nucleotide receptors in the human genome.
Since the first identification of P2Y receptor sequences in 1993, it has quickly become apparent that this family of the G-protein coupled receptors is very diverse. Members of this receptor family are activated extra-cellularly by a wide variety of adenosine and uridine nucleotides including sugar-nucleotides. The recent decipherment of the Human Genome has enabled us to search for new, yet undiscovered P2Y receptor subtypes. In this article we examine the relationships of six orphan G-protein coupled receptor (GPCR) sequences which show considerable sequence homology to various P2Y receptors. The clustering at a few chromosomal loci of P2Y receptor genes and their related orphan genes further suggests that particular P2Y subsets were derived from the same ancestral gene during evolution.
Simon
J
J
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK. js10041@cam.ac.uk
Barnard
E A
EA
D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D003001:Cloning, Molecular; D000242:Cyclic AMP / Q000378:metabolism; D019143:Evolution, Molecular; D019204:GTP-Binding Proteins / Q000235:genetics; D015894:Genome, Human; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D018048:Receptors, Purinergic P2 / Q000737:chemistry / Q000235:genetics*; D017386:Sequence Homology, Amino Acid
D043562:Receptors, G-Protein-Coupled; D018048:Receptors, Purinergic P2; D000242:Cyclic AMP; D019204:GTP-Binding Proteins