title: Periradicular radiographic assessment in diabetic and control individuals.
abstract: OBJECTIVE
  The purpose of this study was to investigate the prevalence of radiographic periradicular radiolucencies in endodontically treated and untreated teeth in patients with and without diabetes.
  
  
  METHODS
  The records of 30 subjects with diabetes and 23 control subjects attending the Endodontic Graduate Clinic at the University of Florida, Gainesville, were reviewed. The number of teeth with root canal treatments with and without periradicular radiolucencies and the number of teeth without endodontic treatment but with periradicular lesions were recorded.
  
  
  RESULTS
  There were no main effects of sex, diabetes diagnosis, or age (the covariate) on the 3 outcomes of interest- nonsurgical endodontic treatment (NSE) with lesions, NSE without lesions, and no NSE with lesions. However, there were significant interactions between sex and diabetes diagnosis for both of the endodontic outcomes, NSE with lesions (F = 4.292; P <.05) and NSE without lesions (F = 4.241; P <.05). This meant that men with type 2 diabetes who had endodontic treatments were more likely to have residual lesions after treatment.
  
  
  CONCLUSIONS
  Type 2 diabetes is associated with an increased risk of ill response by the periradicular tissues to odontogenic pathogens.
authors.affiliation: Department of Endodontics, College of Dentistry, University of Florida, Gainesville 32610-0436, USA. lbritto@dental.ufl.edu
authors.forename: Leandro R
authors.initials: LR
authors.lastname: Britto
authors.forename: Joseph
authors.initials: J
authors.lastname: Katz
authors.forename: Marcio
authors.initials: M
authors.lastname: Guelmann
authors.forename: Marc
authors.initials: M
authors.lastname: Heft
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016022:Case-Control Studies; D019232:Dental Restoration Failure; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010485:Periapical Periodontitis / Q000000981:diagnostic imaging / Q000209:etiology*; D011859:Radiography; D012390:Root Canal Therapy / Q000009:adverse effects*; D012737:Sex Factors