MELAS as an example of a mitochondrial disease.
MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes) is a disease mainly due to a mutation at position 3243 (A --> G) in the leucine tRNA gene in mitochondrial DNA. Symptoms of the disorder are complex and the exact pathogenesis is not understood. A review of the literature on the subject is presented.
Piechota
J
J
Department of Genetics, University of Warsaw, Warszawa, Poland.
Mroczek
K
K
Bartnik
E
E