title: Contraindicated antiretroviral drug combinations.
abstract: The proper implementation of combination antiretroviral treatment regimens is fundamental to successful therapeutic outcomes for patients with HIV/AIDS. Unfortunately, some patients are still being prescribed contraindicated antiretroviral regimens that include: 1. stavudine plus zidovudine; 2. Invirase plus two nucleoside analog reverse transcriptase inhibitors (NRTIS); 3. zalcitabine plus didanosine; 4. zalcitabine plus stavudine; and, 5. zalcitabine plus lamivudine. Inappropriate regimens such as these either have limited effectiveness or potential severe toxicity.
authors.affiliation: Division of Service Systems, HIV/AIDS Bureau, Health Resources and Services Administration, U.S. Public Health Service, Rockville, Maryland, USA.
authors.forename: Abe
authors.initials: A
authors.lastname: Macher
authors.forename: David
authors.initials: D
authors.lastname: Thomas
authors.forename: Sindy M
authors.initials: SM
authors.lastname: Paul
mesh_terms: D044966:Anti-Retroviral Agents / Q000008:administration & dosage; D000075202:Contraindications; D016049:Didanosine / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage; D019258:Saquinavir / Q000008:administration & dosage; D018119:Stavudine / Q000008:administration & dosage; D016047:Zalcitabine / Q000008:administration & dosage
chemical_list: D044966:Anti-Retroviral Agents; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine; D016047:Zalcitabine; D018119:Stavudine; D016049:Didanosine; D019258:Saquinavir