Involvement of transmitters in pituitary adenylate cyclase-activating polypeptide-induced hyperthermia.
The involvement of transmitters in the hyperthermic effect of centrally administered pituitary adenylate cyclase-activating polypeptide (PACAP-38) was studied. Rats were treated with different receptor antagonists or agonists in doses that per se proved to be ineffective. The following agonists and antagonists were used: haloperidol, phenoxybenzamine, propranolol, atropine, bicuculline, naloxone, apomorphine, bromocriptine and methysergide. Apomorphine and bromocriptine enhanced the elevation of body temperature induced by PACAP-38. The PACAP-38-hyperthermia was antagonized by haloperidol while other receptor blockers used were ineffective. Our results suggest that dopaminergic but not cholinergic, noradrenergic, serotoninergic, GABA-ergic or opioid mediation may be involved in the hyperthermic effect of PACAP-38 in rats.
Pataki
Imre
I
Department of Pathophysiology, Albert Szent-Györgyi Medical and Pharmaceutical Center, University of Szeged, MTA-SZTE Neurohumoral Research Group, Semmelweis u. 1., Pf. 427, H6701 Szeged, Hungary.
Adamik
Agnes
A
Jászberényi
Miklós
M
Mácsai
Mónika
M
Telegdy
Gyula
G
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D001971:Bromocriptine / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009479:Neuropeptides; D018377:Neurotransmitter Agents / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
C495403:Adcyap1 protein, rat; D018492:Dopamine Antagonists; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D001971:Bromocriptine; D006220:Haloperidol; D001058:Apomorphine