Total chemical synthesis of enzymes.
The total synthesis, at will, of a wide variety of protein and enzyme molecules is made feasible by modem chemical ligation methods. As Emil Fischer intuitively understood, synthetic access to the enzyme molecule enables the power of chemical science to be applied to elucidating the molecular basis of catalytic function in unprecedented detail.
Kent
Stephen
S
Institute for Biophysical Dynamics, Department of Chemistry, The University of Chicago, IL 60637, USA. skent@uchicago.edu
D000595:Amino Acid Sequence; D004798:Enzymes / Q000138:chemical synthesis* / Q000266:history*; D005544:Forecasting; D054501:Group II Phospholipases A2; D016333:HIV Protease / Q000138:chemical synthesis; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010741:Phospholipases A / Q000138:chemical synthesis; D011487:Protein Conformation; D017510:Protein Folding; D017434:Protein Structure, Tertiary
D004798:Enzymes; D010741:Phospholipases A; D054501:Group II Phospholipases A2; D016333:HIV Protease