Tumor oximetry: comparison of 19F MR EPI and electrodes.
We recently described a novel approach to measuring regional tumor oxygen tension. This approach is based on 19F pulse burst saturation recovery NMR echo planar imaging relaxometry of hexafluorobenzene or "FREDOM" (Fluorocarbon Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping). We have now compared oxygen tension measurements using FREDOM with a traditional polarographic method (the Eppendorf Histograph) in a group of size matched Dunning prostate rat tumors R3327-AT1. We also compare MR and electrode approaches to monitoring dynamic changes with respect to interventions and demonstrate extension of the MR technique to rat breast tumors.
Mason
Ralph P
RP
U.T. Southwestern Medical Center, Dallas, TX 75390, USA.
Hunjan
Sandeep
S
Constantinescu
Anca
A
Song
Yulin
Y
Zhao
Dawen
D
Hahn
Eric W
EW
Antich
Peter P
PP
Peschke
Peter
P
D000230:Adenocarcinoma / Q000378:metabolism*; D000818:Animals; D004566:Electrodes; D005461:Fluorine; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010092:Oximetry / Q000295:instrumentation / Q000379:methods*; D011471:Prostatic Neoplasms / Q000378:metabolism*; D051381:Rats
D005461:Fluorine