Factor VIII: structure, function and analysis.
Factor VIII is an important blood coagulation protein whose genetic deficiency leads to the serious bleeding disorder, classic haemophilia (haemophilia A). Here we review the structure, function and analysis of this protein for diagnostic and therapeutic applications. Because factor VIII is tightly associated with von Willebrand factor some recent work on the latter is also considered so as to clarify the relationship between them.
Manning
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F
School of Biological Sciences, Dublin City University, Republic of Ireland.
O Fágáin
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C
O'Kennedy
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R