Synthesis of dinucleoside boranophosphates by a boranophosphotriester approach.
Dinucleoside boranophosphates including four kinds of nucleobases were synthesized by a boranophosphotriester method in good yields. In the present boranophosphotriester method, side-reactions at the nucleobases, which caused by a borane reagent, were completely avoided.
Wada
Takeshi
T
Department of Integrated Biosciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan. wada@k.u.tokyo.ac.jp
Shimizu
Mamoru
M
Oka
Natsuhisa
N
Saigo
Kazuhiko
K
D001896:Boron Compounds; D007202:Indicators and Reagents; D009705:Nucleosides / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis
D001896:Boron Compounds; D007202:Indicators and Reagents; D009705:Nucleosides; D009838:Oligodeoxyribonucleotides; D016376:Oligonucleotides, Antisense; C028270:dinucleoside dimers