title: Loss of an MDR transporter in compact stalks of maize br2 and sorghum dw3 mutants.
abstract: Agriculturally advantageous reduction in plant height is usually achieved by blocking the action or production of gibberellins. Here, we describe a different dwarfing mechanism found in maize brachytic2 (br2) mutants characterized by compact lower stalk internodes. The height reduction in these plants results from the loss of a P-glycoprotein that modulates polar auxin transport in the maize stalk. The sorghum ortholog of br2 is dwarf3 (dw3), an unstable mutant of long-standing commercial interest and concern. A direct duplication within the dw3 gene is responsible for its mutant nature and also for its instability, because it facilitates unequal crossing-over at the locus.
authors.affiliation: Pioneer Hi-Bred International, 7250 Northwest 62nd Avenue, Johnston, IA 50131, USA.
authors.forename: Dilbag S
authors.initials: DS
authors.lastname: Multani
authors.forename: Steven P
authors.initials: SP
authors.lastname: Briggs
authors.forename: Mark A
authors.initials: MA
authors.lastname: Chamberlin
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Blakeslee
authors.forename: Angus S
authors.initials: AS
authors.lastname: Murphy
authors.forename: Gurmukh S
authors.initials: GS
authors.lastname: Johal
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D001692:Biological Transport; D003001:Cloning, Molecular; D003434:Crossing Over, Genetic; D020440:Gene Duplication; D017343:Genes, Plant; D005808:Genes, Recessive; D007210:Indoleacetic Acids / Q000378:metabolism*; D008027:Light; D008969:Molecular Sequence Data; D009154:Mutation; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D018547:Plant Stems / Q000166:cytology / Q000378:metabolism; D006109:Poaceae / Q000166:cytology / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D011995:Recombination, Genetic; D003313:Zea mays / Q000166:cytology / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*
chemical_list: D018435:ATP Binding Cassette Transporter, Subfamily B; D007210:Indoleacetic Acids; D010940:Plant Proteins; C030737:indoleacetic acid