title: Piericidins C5 and C6: new 4-pyridinol compounds produced by Streptomyces sp. and Nocardioides sp.
abstract: Piericidins C5 (1) and C6 (2), two new members of the piericidin family, were isolated from a Streptomyces sp. and a Nocardioides sp., together with known piericidins C1 (3), C2 (4), C3 (5), C4 (6), D1 (7), and A3 (8). The structures were determined on the basis of their spectroscopic data. Both new compounds inhibited cell division of fertilized starfish (Asterina pectinifera) eggs at the minimum inhibitory concentration of 0.09 microg/mL.
authors.affiliation: Instrument Center for Chemical Analysis, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan.
authors.forename: Natsuki K
authors.initials: NK
authors.lastname: Kubota
authors.forename: Emi
authors.initials: E
authors.lastname: Ohta
authors.forename: Shinji
authors.initials: S
authors.lastname: Ohta
authors.forename: Fumito
authors.initials: F
authors.lastname: Koizumi
authors.forename: Makoto
authors.initials: M
authors.lastname: Suzuki
authors.forename: Michio
authors.initials: M
authors.lastname: Ichimura
authors.forename: Susumu
authors.initials: S
authors.lastname: Ikegami
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D009618:Nocardiaceae / Q000378:metabolism*; D011725:Pyridines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D011728:Pyridones; D013215:Starfish / Q000737:chemistry / Q000187:drug effects; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D011725:Pyridines; D011728:Pyridones; C487579:piericidin C5; C487580:piericidin C6; C534143:4-pyridone