title: Gene therapy. Therapeutic approaches and implications.
abstract: The present article is an overview of gene therapy with an emphasis on different approaches and its implications in the clinic. Genetic interventions have been applied to the diagnosis of and therapy for an array of human diseases. The initial concept of gene therapy was focused on the treatment of genetic diseases. Subsequently, the field of gene therapy has been expanded, with a major focus on cancer. Although the results of early gene therapy-based clinical trials have been encouraging, there is a need for gene delivery vectors that feature reduced immunogenicity and improved targeting ability. The results of phases I/II clinical trials have suggested the important role of gene therapy as a versatile and powerful treatment tool, especially for human cancers. One reasonable expectation is that performing gene therapy at an earlier stage in the disease process or for minimal residual disease may be more advantageous.
authors.affiliation: Introgen Therapeutics, Inc., Houston, TX 77030, USA.
authors.forename: A
authors.initials: A
authors.lastname: Mhashilkar
authors.forename: S
authors.initials: S
authors.lastname: Chada
authors.forename: J A
authors.initials: JA
authors.lastname: Roth
authors.forename: R
authors.initials: R
authors.lastname: Ramesh