title: Increase in error threshold for quasispecies by heterogeneous replication accuracy.
abstract: In this paper we investigate the error threshold for quasispecies with heterogeneous replication accuracy. We show that the coexistence of error-free and error-prone polymerases can greatly increase the error threshold without a catastrophic loss of genetic information. We also show that the error threshold is influenced by the number of replicores. Our research suggests that quasispecies with heterogeneous replication accuracy can reduce the genetic cost of selective evolution while still producing a variety of mutants.
authors.affiliation: White-Bird Institute, 1-14-9 Hanabatake, Tsukuba, Ibaraki 300-3261, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Aoki
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Furusawa
mesh_terms: D004247:DNA / Q000737:chemistry*; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D016680:Genome, Bacterial; D008957:Models, Genetic; D015233:Models, Statistical; D009154:Mutation; D013045:Species Specificity
chemical_list: D004247:DNA; D004259:DNA-Directed DNA Polymerase