Detection of ligands from a dynamic combinatorial library by X-ray crystallography.
Congreve
Miles S
MS
Astex Technology, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, UK. m.congreve@astex-technology.com
Davis
Deborah J
DJ
Devine
Lindsay
L
Granata
Cesare
C
O'Reilly
Marc
M
Wyatt
Paul G
PG
Jhoti
Harren
H
D001681:Biological Assay; D042846:CDC2-CDC28 Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D018360:Crystallography, X-Ray; D051357:Cyclin-Dependent Kinase 2; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
D008024:Ligands; D042846:CDC2-CDC28 Kinases; D051357:Cyclin-Dependent Kinase 2