Patients with auditory neuropathy/dys-synchrony lack efferent suppression of transient evoked otoacoustic emissions.
Function of the olivocochlear reflex, measured by suppression of transient evoked otoacoustic emissions, is assessed in nine patients with bilateral auditory neuropathy/dys-synchrony and compared to matched control subjects with normal auditory function. TEOAEs were acquired using 65 dB peak sound pressure linear clicks with and without the presence of broad-band noise presented binaurally, ipsilaterally, or contralaterally in a forward masking paradigm. Efferent suppression differed significantly between subject groups (p < .0001). Mean suppression was less than 0.22 dB across all suppressor noise conditions for the auditory neuropathy/dys-synchrony subjects. TEOAE suppression averaged 4.47 (binaural), 2.41 (ipsilateral), and 1.52 (contralateral) dB in the control subjects. Suppression characteristics across the three suppressor conditions were also assessed in one patient with unilateral auditory neuropathy/dys-synchrony. The results suggest that poor efferent responses are related to compromised afferent input to the OCR pathway and support the use of efferent suppression of otoacoustic emissions as a differential measure of auditory function in patients with auditory neuropathy/dys-synchrony.
Hood
Linda J
LJ
Kresge Hearing Research Laboratory, Department of Otorhinolaryngology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA. LHOOD@LSUHSC.EDU
Berlin
Charles I
CI
Bordelon
Jill
J
Rose
Kelly
K
D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D001306:Auditory Pathways / Q000503:physiopathology*; D001309:Auditory Threshold; D002648:Child; D005260:Female; D006311:Hearing Disorders / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous