State-related thalamic changes during antipsychotic treatment in schizophrenia: preliminary observations.
Thalamic volumes and psychotic symptoms were assessed during psychotic exacerbation and during antipsychotic drug treatment. Reduction of psychotic symptoms (SAPS) during four weeks of treatment was highly correlated with volumetric expansion as measured by magnetic resonance imaging in both left and right thalamus [r(s)=0.75 and r(s)=0.82, respectively (both P<0.04)].
Strungas
Sasa
S
Department of Psychiatry and Behavioral Science, University of Louisville School of Medicine, MedCenter One, Suite 340, 501 West Broadway, Louisville, KY 40202, USA.
Christensen
James D
JD
Holcomb
Jennifer M
JM
Garver
David L
DL
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016571:Neural Networks, Computer; D011569:Psychiatric Status Rating Scales; D015203:Reproducibility of Results; D018967:Risperidone / Q000009:adverse effects / Q000627:therapeutic use*; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D013223:Statistics as Topic; D013788:Thalamus / Q000187:drug effects* / Q000473:pathology
D014150:Antipsychotic Agents; D018967:Risperidone