title: Introduction to micro-analytical systems: bioanalytical and pharmaceutical applications.
abstract: This review presents a brief overview of recent developments in miniaturization of analytical instruments utilizing microfabrication technology. The concept 'Micro-Total Analysis Systems micro-TAS)', also termed 'Lab-on-a-chip', and the latest progresses in the development of microfabricated separation devices and on-chip detection techniques are discussed. Applications of micro-analytical methods to bioanalytical and pharmaceutical studies are also described, including chemical reactions, assays, and analytical separations of biomolecules in micro-scale.
authors.affiliation: Department of Pharmacy, PO Box 56, FIN-00014 University of Helsinki, Helsinki, Finland. katri.huikko@helsinki.fi
authors.forename: Katri
authors.initials: K
authors.lastname: Huikko
authors.forename: Risto
authors.initials: R
authors.lastname: Kostiainen
authors.forename: Tapio
authors.initials: T
authors.lastname: Kotiaho
mesh_terms: D000818:Animals; D002623:Chemistry Techniques, Analytical; D002626:Chemistry, Pharmaceutical; D002849:Chromatography, Gas / Q000295:instrumentation; D019075:Electrophoresis, Capillary / Q000295:instrumentation; D006801:Humans; D013058:Mass Spectrometry; D008838:Microcomputers; D008967:Molecular Biology; D036103:Nanotechnology; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet