title: Current and future directions in the treatment of metastatic malignant melanoma.
abstract: Recently treatment strategies in advanced malignant melanoma have significantly changed. Due to high response rates (e.g. more than 50% for the Dartmouth-regimen), combination chemotherapy has been the standard therapy in several oncological and dermatooncological centers in the USA and Europe. For the last three years different prospective randomized phase III trials failed to achieve similar results. There was no benefit in overall survival and in response duration in comparison to single agent chemotherapy. Currently, randomized clinical trials seem to be the best approach for the clinical treatment of metastatic melanoma. In this review several novel strategies against malignant melanoma are discussed with focus on the role of single agent chemotherapy and biochemotherapy.
authors.affiliation: Department of Dermatology and Allergology, RWTH Aachen, Aachen, Germany.
authors.forename: J M
authors.initials: JM
authors.lastname: Baron
authors.forename: R
authors.initials: R
authors.lastname: Heise
authors.forename: H F
authors.initials: HF
authors.lastname: Merk
authors.forename: F
authors.initials: F
authors.lastname: Abuzahra
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000556:secondary / Q000628:therapy; D003131:Combined Modality Therapy; D006801:Humans; D008545:Melanoma / Q000473:pathology* / Q000628:therapy*; D009362:Neoplasm Metastasis / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents