title: Overexpression of X-linked inhibitor of apoptosis in human hepatocellular carcinoma.
abstract: The X-linked inhibitor of apoptosis (XIAP) is a member of a novel family of inhibitors of apoptosis. Since suppression of apoptosis is fundamentally important for carcinogenesis and tumor growth, we investigated the expression and function of XIAP in human hepatocellular carcinomas (HCCs). XIAP was expressed constitutively in HCC cell lines. Fourteen out of 20 (70%) HCC tissues demonstrated moderate or strong cytoplasmic staining for XIAP, whereas non-tumor parts showed negative or weak staining for XIAP by immunohistochemistry. In addition, XIAP expression was inversely correlated with apoptosis, but not with proliferation in HCC tissues. These results indicated that XIAP is a principal inhibitor of apoptosis overexpressed in human HCCs and that XIAP may be a potential target for gene therapy of human HCCs.
authors.affiliation: First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514-8507, Japan. katsuyas@clin.medic.mie-u.ac.jp
authors.forename: Katsuya
authors.initials: K
authors.lastname: Shiraki
authors.forename: Kazushi
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamanaka
authors.forename: Yumi
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Saitou
authors.forename: Keiichi
authors.initials: K
authors.lastname: Ito
authors.forename: Norihiko
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Takenari
authors.initials: T
authors.lastname: Yamanaka
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Fujikawa
authors.forename: Kazumoto
authors.initials: K
authors.lastname: Murata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakano
mesh_terms: D017209:Apoptosis; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D002455:Cell Division; D045744:Cell Line, Tumor; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D011506:Proteins / Q000378:metabolism*; D051636:X-Linked Inhibitor of Apoptosis Protein
chemical_list: D011506:Proteins; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human