title: Sulphonamide-based small molecule VLA-4 antagonists.
abstract: The discovery of a sulphonamide by-product with VLA-4 antagonistic activity led to a series of potent, small molecule VLA-4 antagonists. Synthesis, SAR and in vivo evaluation of the selected compound will be presented.
authors.affiliation: Molecumetics, 2023 120th Avenue N E., Bellevue, WA 98005, USA.
authors.forename: Marcin
authors.initials: M
authors.lastname: Stasiak
authors.forename: Christopher
authors.initials: C
authors.lastname: Mehlin
authors.forename: Erica
authors.initials: E
authors.lastname: Boni
authors.forename: Tomas
authors.initials: T
authors.lastname: Vaisar
authors.forename: Thomas
authors.initials: T
authors.lastname: Little
authors.forename: Hwa-Ok
authors.initials: HO
authors.lastname: Kim
authors.forename: Maher
authors.initials: M
authors.lastname: Qabar
mesh_terms: D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000473:pathology; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects; D004804:Eosinophils / Q000187:drug effects; D005260:Female; D006207:Half-Life; D007202:Indicators and Reagents; D039041:Integrin alpha4beta1 / Q000037:antagonists & inhibitors*; D007962:Leukocytes / Q000187:drug effects; D008252:Macaca fascicularis; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D007202:Indicators and Reagents; D039041:Integrin alpha4beta1; D013449:Sulfonamides; D010047:Ovalbumin