title: Oligonucleotides containing an acridine group covalently bonded to the nucleotide flanking the 3'-3' phosphodiester junction for alternate strand triple helix formation.
abstract: Oligonucleotides with a 3'-3' inversion of polarity and containing an acridine group attached to nucleotide base flanking the 3'-3' phosphodiester bon have been synthesized, characterized and used as third strand in alternate triple helix formation. CD melting studies and molecular mechanics calculations have been carried out to investigate these triplex structures.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Napoli, Italy.
authors.forename: Bruno
authors.initials: B
authors.lastname: Catalanotti
authors.forename: Caterina
authors.initials: C
authors.lastname: Fattorusso
authors.forename: Luciano
authors.initials: L
authors.lastname: Mayol
authors.forename: Giorgia
authors.initials: G
authors.lastname: Oliviero
authors.forename: Gennaro
authors.initials: G
authors.lastname: Piccialli
authors.forename: Michela
authors.initials: M
authors.lastname: Varra
mesh_terms: D000166:Acridines; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D010710:Phosphates / Q000737:chemistry*
chemical_list: D000166:Acridines; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D010710:Phosphates