title: The novel gluconeogenesis inhibitors FR225659 and related compounds that originate from Helicomyces sp. No. 19353. II. Biological profiles.
abstract: The novel gluconeogenesis inhibitor FR225659 and four related compounds were isolated from the cultured broth of a fungal strain No. 19353. These compounds inhibited the glucagon-stimulated gluconeogenesis of rat primary hepatocytes and had hypoglycemic effects in two different in vivo models.
authors.affiliation: Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. yoshihiro_ohtsu@po.fujisawa.co.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ohtsu
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sasamura
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Shibata
authors.forename: Hidenori
authors.initials: H
authors.lastname: Nakajima
authors.forename: Motohiro
authors.initials: M
authors.lastname: Hino
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujii
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D005260:Female; D005943:Gluconeogenesis / Q000187:drug effects*; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D006943:Hyperglycemia / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D051381:Rats
chemical_list: D007004:Hypoglycemic Agents