Budding and tubulation in highly oblate vesicles by anchored amphiphilic molecules.
We studied local budding and tubulation induced in highly oblate lipid vesicles by the anchoring of either polymers having a hydrophilic backbone and grafted hydrophobic anchor groups, or by oleoyl-coenzyme A, an amphiphilic molecule important in lipid metabolism. The dynamics of bud formation, shrinkage, and readsorption is consistent with an induced spontaneous curvature coupled with local amphiphile diffusion on the membrane. We report a novel metastable state prior to bud readsorption.
Tsafrir
Ilan
I
Department of Physics of Complex Systems, The Weizmann Institute of Science, Rehovot 76100, Israel.
Caspi
Yaron
Y
Guedeau-Boudeville
Marie-Alice
MA
Arzi
Tamar
T
Stavans
Joel
J
D022162:Cytoplasmic Vesicles / Q000737:chemistry / Q000378:metabolism; D008081:Liposomes / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry*
D008081:Liposomes; D010713:Phosphatidylcholines; C027891:1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine