[Comparative choleretic properties of natural xanthone compounds from Gentianopsis barbata].
Comparative data are presented for the choleretic activity of xanthones isolated from Gentianopsis barbata (Froel.) Ma. (Gentianaceae family): a sum of xanthone glycosides (I) and aglycons (II); xanthone aglycons, including decussatin [1-(OH)-3,7,8-(OCH3)3] (III) and gentiacaulein [1,7-(OH)-3,8-(OCH3)2] (IV); and xanthone glycoside gentiabavaroside [1-O-primverosyl-7-(OH)-3,8-(OCH3)2] (V). It was established that (II) is superior to (I) with respect to cholagogic effect and is inferior to (III) and (IV) with respect to cholatostimulant action.
Nikolaev
S M
SM
Laboratory of Experimental Pharmacology, Institute of General and Experimental Biology, Siberian Division, Russian Academy of Sciences, ul. Sakh'yanova 6, Ulan-Ude, 670047 Russia.
Sambueva
Z G
ZG
Tsyrenzhapov
A V
AV
Nikolaeva
G G
GG
Tankhaeva
L M
LM
Glyzin
V I
VI
Dargaeva
T D
TD
D000818:Animals; D001646:Bile / Q000737:chemistry / Q000378:metabolism; D002756:Cholagogues and Choleretics / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D029965:Gentianaceae; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D014966:Xanthenes / Q000737:chemistry / Q000494:pharmacology*
D002756:Cholagogues and Choleretics; D010936:Plant Extracts; D014966:Xanthenes