A non-invasive method for observing hippocampal function.
A non-invasive method for observing the functioning of the hippocampus could be invaluable in understanding the role of hippocampal abnormalities in many brain disorders. Transverse patterning, a hippocampal-dependent memory task, was used in an attempt to study the functioning hippocampus. Subjects performed transverse patterning while whole-head MEG data were collected. The MEG data were analyzed using a spatial-temporal multiple-dipole approach. Controls showed right hippocampal activation. Patients with unilateral hippocampal damage showed activation in undamaged hippocampus. MEG during transverse patterning performance is a promising, non-invasive tool for assessing hippocampal function.
Hanlon
Faith M
FM
New Mexico VA Health Care System, 1501 San Pedro Drive, SE Albuquerque, NM 87108, USA.
Weisend
Michael P
MP
Huang
Mingxiong
M
Lee
Roland R
RR
Moses
Sandra N
SN
Paulson
Kim M
KM
Thoma
Robert J
RJ
Miller
Gregory A
GA
Cañive
Jose M
JM
D000328:Adult; D005260:Female; D006624:Hippocampus / Q000293:injuries / Q000473:pathology / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D009010:Monte Carlo Method; D010775:Photic Stimulation; D012598:Sclerosis; D013702:Temporal Lobe / Q000293:injuries / Q000473:pathology; D014202:Tremor / Q000473:pathology