title: An approach to assessment of endocrine disruption in the National Children's Study.
abstract: In this article we consider the importance of assessing endocrine disruption in a large new cohort that has been proposed, the National Children's Study (NCS). We briefly review evidence that endocrine disruption is a potentially important hypothesis for human studies and weigh the need to assess endocrine disruption in the NCS. We note the salient features of earlier, similar cohort studies that serve as reference points for the design of the NCS. Finally, we discuss features of the NCS that would allow or enhance assessment of endocrine disruption, even if endocrine disruption were not a primary hypothesis motivating the study. At this time, the evidence supporting endocrine disruption in humans with background-level exposures is not strong. Thus, a compelling rationale for the NCS will probably need to be based on core hypotheses that focus on other issues. Nonetheless, if properly designed, the NCS could serve as an excellent resource for investigating future hypotheses regarding endocrine disruption.
authors.affiliation: Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina 27709, USA. longnecker@niehs.nih.gov
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Longnecker
authors.forename: David C
authors.initials: DC
authors.lastname: Bellinger
authors.forename: David
authors.initials: D
authors.lastname: Crews
authors.forename: Brenda
authors.initials: B
authors.lastname: Eskenazi
authors.forename: Ellen K
authors.initials: EK
authors.lastname: Silbergeld
authors.forename: Tracey J
authors.initials: TJ
authors.lastname: Woodruff
authors.forename: Ezra S
authors.initials: ES
authors.lastname: Susser
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D015331:Cohort Studies; D004703:Endocrine System / Q000187:drug effects*; D004785:Environmental Pollutants / Q000633:toxicity*; D016021:Epidemiologic Studies; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012107:Research Design
chemical_list: D004785:Environmental Pollutants