Synthesis of beta-substituted cationic porphyrins and their interactions with DNA.
The beta-substituted cationic porphyrins (7, 8 and 10) have been synthesized and their interactions with plasmid DNA investigated. We found that substituents at the beta-position of porphyrins (7 and 8) have apparently affected their interactions with DNA compared with non-beta-substituted porphyrins (10).
Chen
Bo
B
College of Chemistry and Molecular Sciences, Wuhan University, Hubei Wuhan 430072, P.R. China.
Qin
Wen
W
Wang
Ping
P
Tian
Tian
T
Ma
Hongjuan
H
Cao
Xiaoping
X
Wu
Xiaojun
X
Zhou
Xiang
X
Zhang
Xiao-Lian
XL
Liu
Fang
F
Zheng
Fang
F
Li
Xia
X
D000042:Absorption; D002412:Cations; D004247:DNA / Q000187:drug effects*; D004249:DNA Damage; D004587:Electrophoresis, Agar Gel; D010777:Photochemistry; D010957:Plasmids / Q000187:drug effects; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D002412:Cations; D011166:Porphyrins; D004247:DNA