title: Quantification of ovarian power Doppler signal with three-dimensional ultrasonography to predict response during in vitro fertilization.
abstract: OBJECTIVE
  To evaluate whether power Doppler predicts ovarian response to gonadotrophin stimulation during in vitro fertilization (IVF).
  
  
  METHODS
  Forty-five women were divided into low-reserve (n = 12) and normal-reserve (n = 33) ovarian groups, according to antral follicle count. Transvaginal three-dimensional power Doppler ultrasonographic examinations were performed after pituitary downregulation and after gonadotrophin stimulation. The antral follicle count, ovarian volume, vascularization index, flow index, vascularization flow index, and mean gray value were measured and related to the number of oocytes retrieved and the pregnancy rate.
  
  
  RESULTS
  The number of oocytes retrieved correlated with the antral follicle count (R =.458, P =.004) and ovarian volume (R =.388, P <.016) but not with vascularization index, flow index, vascularization flow index, or mean gray value after pituitary suppression. There was an increase in vascularization index (P <.017), flow index (P <.001), and vascularization flow index (P <.007) during gonadotrophin stimulation in the normal-ovary group but not in the low-ovarian-reserve group.
  
  
  CONCLUSIONS
  According to our results, quantification of power Doppler signal in the ovaries after pituitary suppression does not provide any additional information to predict the subsequent response to gonadotrophin stimulation during IVF. The increase in ovarian power Doppler signal during gonadotrophin stimulation is related to the antral follicle count observed after pituitary suppression.
authors.affiliation: Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland. ijarvela@cc.oulu.fi
authors.forename: Ilkka Y
authors.initials: IY
authors.lastname: Järvelä
authors.forename: Povilas
authors.initials: P
authors.lastname: Sladkevicius
authors.forename: Simon
authors.initials: S
authors.lastname: Kelly
authors.forename: Kamal
authors.initials: K
authors.lastname: Ojha
authors.forename: Stuart
authors.initials: S
authors.lastname: Campbell
authors.forename: Geeta
authors.initials: G
authors.lastname: Nargund
mesh_terms: D000328:Adult; D019560:Echocardiography, Three-Dimensional / Q000592:standards*; D005260:Female; D006062:Gonadotropins / Q000494:pharmacology*; D006801:Humans; D010050:Ovarian Function Tests; D010053:Ovary / Q000000981:diagnostic imaging* / Q000187:drug effects*; D010062:Ovulation Induction; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D016216:Ultrasonography, Prenatal / Q000592:standards*
chemical_list: D006062:Gonadotropins