Pharmacogenomics in colorectal cancer.
The goal in administering chemotherapeutics is to develop the ability to predict the outcome of therapy in terms of response and toxicity. Technology has been developed to allow tumor profiling with the measurement of protein expression and gene expression levels of markers and even genetic polymorphisms that may predict response to particular chemotherapeutics. The chemotherapeutics for which particular markers have been shown to predict outcome include the fluoropyrimidines and platinums. The next step is to develop clinical trials that will prospectively assess the benefits of profiling a patient's particular tumor, which should translate into an improvement in response and toxicity.
Lenz
Heinz Josef
HJ
Division of Oncology, University of Southern California/Norris Comprehensive Cancer Center, USC Keck School of Medicine, Los Angeles, CA 90033, USA.
D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology*; D002945:Cisplatin / Q000494:pharmacology; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D004265:DNA Helicases; D004260:DNA Repair; D004268:DNA-Binding Proteins; D042943:Dihydrouracil Dehydrogenase (NADP); D066246:ErbB Receptors / Q000235:genetics / Q000502:physiology; D005472:Fluorouracil / Q000494:pharmacology*; D005544:Forecasting; D015972:Gene Expression Regulation, Neoplastic; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000235:genetics / Q000494:pharmacology; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000494:pharmacology; D010088:Oxidoreductases / Q000235:genetics / Q000494:pharmacology; D010597:Pharmacogenetics; D011506:Proteins / Q000235:genetics / Q000494:pharmacology; D013940:Thymidylate Synthase / Q000096:biosynthesis / Q000235:genetics* / Q000494:pharmacology; D014157:Transcription Factors; D051759:Xeroderma Pigmentosum Group D Protein
D000964:Antimetabolites, Antineoplastic; D004268:DNA-Binding Proteins; D007527:Isoenzymes; D011506:Proteins; D014157:Transcription Factors; D010088:Oxidoreductases; D042943:Dihydrouracil Dehydrogenase (NADP); D013940:Thymidylate Synthase; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D066246:ErbB Receptors; D004265:DNA Helicases; D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human; D002945:Cisplatin; D005472:Fluorouracil