Bone marrow-derived vascular cells in response to injury.
Intimal hyperplasia is a key lesion for various vascular disorders such as atherosclerosis, postangioplasty restenosis and transplant arteriopathy. It has widely been accepted that intimal smooth muscle cells (SMC) originate from the medial layer in the same artery. However, recent studies suggest that bone marrow can also provide circulating progenitors for vascular SMC. Bone marrow-derived SMC participate in neointimal formation in animal models of allotransplantation, severe mechanical injury and hyperlipidemia-induced atherosclerosis. In human, transplantation arteriopathy also seems to involve circulating SMC, but their role in atherosclerosis and restenosis remains to be elucidated. Mobilization, differentiation and proliferation steps of SMC progenitors will provide promising targets for novel therapeutic approaches against proliferative vascular diseases.
Yokote
Koutaro
K
Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan. kyokote-cib@umin.ac.jp
Take
Ayako
A
Nakaseko
Chiaki
C
Kobayashi
Kazuki
K
Fujimoto
Masaki
M
Kawamura
Harukiyo
H
Maezawa
Yoshiro
Y
Nishimura
Miki
M
Mori
Seijiro
S
Saito
Yasushi
Y
D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology*; D001808:Blood Vessels / Q000166:cytology; D001854:Bone Marrow Cells / Q000502:physiology*; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000293:injuries / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology; D014180:Transplantation; D017539:Tunica Intima / Q000166:cytology; D017540:Tunica Media / Q000166:cytology