Protein surface recognition by rational design: nanomolar ligands for potassium channels.
The rational design and development of four-fold symmetrical ligands for potassium channels is described.
Gradl
Stefan N
SN
Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, Berkeley, California 94720-1460, USA. trauner@cchem.berkeley.edu
Felix
John P
JP
Isacoff
Ehud Y
EY
Garcia
Maria L
ML
Trauner
Dirk
D
D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D001667:Binding, Competitive; D007700:Kinetics; D008024:Ligands; D008969:Molecular Sequence Data; D011166:Porphyrins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D026902:Potassium Channel Blockers / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D015221:Potassium Channels / Q000737:chemistry* / Q000378:metabolism; D051637:Shaker Superfamily of Potassium Channels; D013499:Surface Properties; D014981:Xenopus
D001426:Bacterial Proteins; D008024:Ligands; D011166:Porphyrins; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D051637:Shaker Superfamily of Potassium Channels; C107790:prokaryotic potassium channel