title: Therapeutic and reproductive cloning--implications and recommendations.
abstract: The announcement of Dolly's birth took the world by storm, mainly because what was thought impossible has become possible. Optimism that new approaches in agriculture and medicine abound, as much as fear and imagination leading to Frankenstein-like scenarios. Scientifically, cloning refers to replicating an animal with the same nuclear genetic material; whilst it may refer to embryos as the source material, the current storm refers to differentiated ("somatic") cells. Cloning technology is useful in the following areas: agriculture, to produce animals of superior or specific qualities; endangered animals, to increase genetic diversity through widening the gene pool; understanding fundamental questions in developmental embryology, through the use of laboratory animals; and in human therapy, to produce cells and possibly tissues for repair and regeneration. In the first 2 instances, it is reproductive cloning. In the last instance, it is therapeutic cloning, as no individuals are "produced". Human reproductive cloning is not allowed by all governments that have deliberated on it, and therapeutic cloning is allowed by some under certain circumstances. As therapeutic cloning has great potential in cures of many diseases, it should be allowed but with safeguards to prevent abuse and reproductive cloning in the human.
authors.affiliation: Department of Obstetrics & Gynaecology, Faculty of Medicine, National University of Singapore, Lower Kent Ridge Road, Singapore 119074.
authors.forename: S C
authors.initials: SC
authors.lastname: Ng
authors.forename: Y
authors.initials: Y
authors.lastname: Ng
authors.forename: S L
authors.initials: SL
authors.lastname: Liow
authors.forename: N
authors.initials: N
authors.lastname: Chen
mesh_terms: D000818:Animals; D019976:Cloning, Organism / Q000941:ethics / Q000331:legislation & jurisprudence* / Q000592:standards*; D006801:Humans