title: Rapid and efficient synthesis of 1H-indol-2-yl-1H-quinolin-2-ones.
abstract: [reaction: see text] A concise and efficient synthesis of the novel indol-2-yl-1H-quinolin-2-one ring system found in the potent and selective KDR kinase inhibitors 1-3 is presented.
authors.affiliation: Department of Process Research, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA.
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Kuethe
authors.forename: Audrey
authors.initials: A
authors.lastname: Wong
authors.forename: Ian W
authors.initials: IW
authors.lastname: Davies