title: [Influence of folic acid in primary prevention of neural tube defects].
abstract: OBJECTIVE
  The aim of the study was to analyze the incidence of neural tube defects in Lublin Province between 1990 and 2000 after application of primary prevention with folic acid.
  
  
  METHODS
  A total of 293,039 newborns were analyzed.
  
  
  RESULTS
  Neural tube defects were diagnosed in 53 newborns.
  
  
  CONCLUSIONS
  Reduction of frequency of meningocele was shown after application of primary prevention with folic acid in 1998. Meningoceles were most frequent in 1992 (1.32/1000) and in 1998 frequency of these defects was reduced and in 2000 was down to 0.62/1000 births.
authors.affiliation: Kliniki Połoznictwa i Patologii Ciazy AM w Lublinie.
authors.forename: Henryka
authors.initials: H
authors.lastname: Sawulicka-Oleszczuk
authors.forename: Marzena
authors.initials: M
authors.lastname: Kostuch
mesh_terms: D005260:Female; D005492:Folic Acid / Q000008:administration & dosage*; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D009436:Neural Tube Defects / Q000453:epidemiology / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D011044:Poland / Q000453:epidemiology; D011322:Primary Prevention / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D018696:Neuroprotective Agents; D005492:Folic Acid