title: Design and synthesis of C3-symmetric Lewis(x) antigen.
abstract: [structure: see text] C(3)-Symmetric glycoconjugates carrying three equivalent Lewis(X) antigens or beta-lactosides were synthesized from p-nitrophenyl glycosides and trimesic acid via regio- and stereocontrolled glycosylation reactions. An (1)H NMR study has shown that the C(3)-symmetric glycoconjugates soluble in water provide useful probes to investigate the Ca(2+)-dependent Lewis(X)-Lewis(X) association.
authors.affiliation: Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan. nishida@mol.nagoya-u.ac.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nishida
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Tsurumi
authors.forename: Kenji
authors.initials: K
authors.lastname: Sasaki
authors.forename: Kenta
authors.initials: K
authors.lastname: Watanabe
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Dohi
authors.forename: Kazukiyo
authors.initials: K
authors.lastname: Kobayashi
mesh_terms: D002118:Calcium / Q000737:chemistry; D002240:Carbohydrate Sequence; D006031:Glycosylation; D006801:Humans; D016256:Lewis X Antigen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data
chemical_list: D016256:Lewis X Antigen; D002118:Calcium