title: Synthesis of oligonucleotide prodrugs bearing N-acetyl nucleobases.
abstract: N-Acetyl oligonucleotides and their prodrugs were synthesized on photolabile solid support. Tm studies showed a decrease of hydridization for N-acetyl A and G and an increase for N-acetyl C. In cells extract, acetyl groups were hydrolysed.
authors.affiliation: Laboratoire de Chimie Organique Biomoléculaire de Synthèse, Université de Montpellier II, UMR 5625 CNRS-UMII, Montpellier Cedex, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Brès
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
authors.forename: F
authors.initials: F
authors.lastname: Morvan
mesh_terms: D000107:Acetylation; D001483:Base Sequence; D006868:Hydrolysis; D007202:Indicators and Reagents; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D007202:Indicators and Reagents; D009705:Nucleosides; D009841:Oligonucleotides; D011355:Prodrugs