Fas (CD95/Apo-1) ligand regulation in T cell homeostasis, cell-mediated cytotoxicity and immune pathology.
Members of the tumor necrosis factor (TNF) superfamily are crucially involved in the regulation of T cell activation, homeostasis and cytotoxicity. In particular, Fas ligand (FasL), expressed by activated T lymphocytes, induces cell-mediated cytotoxicity and may also be responsible for apoptotic suicide. Tight regulation of this death-inducing ligand is a prerequisite for proper immune defense and homeostasis. In this review, we will discuss various aspects of FasL regulation in cell-mediated cytotoxicity, immune homeostasis and the immunopathology of diseases.
Brunner
Thomas
T
Division of Immunopathology, Institute of Pathology, University of Bern, Murtenstrasse 31, P.O. Box 62, 3010 Bern, Switzerland. tbrunner@pathology.unibe.ch
Wasem
Christoph
C
Torgler
Ralph
R
Cima
Igor
I
Jakob
Sabine
S
Corazza
Nadia
N
D000818:Animals; D003602:Cytotoxicity, Immunologic; D053222:Fas Ligand Protein; D006706:Homeostasis; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D014158:Transcription, Genetic / Q000235:genetics
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins