Fasting acylation-stimulating protein is predictive of postprandial triglyceride clearance.
Postprandial plasma triglyceride (ppTG) and NEFA clearance were stratified by plasma acylation-stimulating protein (ASP) and gender to determine the contribution of fasting ASP in a normal population (70 men; 71 women). In the highest ASP tertile only, ASP decreased over 8 h (90 +/- 9.7 nM to 70 +/- 5.9 nM, P<0.05 males; 61.9 +/- 4.0 nM to 45.6 +/- 6.2 nM, P<0.01 females). Fasting ASP correlated positively with ppTG response. ppTG (P<0.0001, 2-way ANOVA, both genders) and NEFA levels progressively increased from lowest to highest ASP tertile, with the greatest differences in males. By stepwise multiple regression, the best prediction of ppTG was: (fasting ASP + apolipoprotein B + insulin + TG; r=0.806) for men and (fasting ASP + total cholesterol; r=0.574) for women. Leptin, body mass index, and other fasting variables did not improve the prediction. Thus, in men and women, ASP significantly predicted ppTG and NEFA clearance and, based on lower ASP, women may be more ASP sensitive than men. Plasma ASP may be useful as a fasting variable that will provide additional information regarding ppTG and NEFA clearance.
Cianflone
Katherine
K
Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Royal Victoria Hospital, 687 Pine Avenue, West Montreal, Quebec H3A 1A1, Canada. katherine.cianflone@mcgill.ca
Zakarian
Robert
R
Couillard
Charles
C
Delplanque
Bernadette
B
Despres
Jean-Pierre
JP
Sniderman
Allan
A
D001798:Blood Proteins / Q000378:metabolism*; D015926:Complement C3a / Q000031:analogs & derivatives*; D005215:Fasting / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D019518:Postprandial Period / Q000502:physiology*; D012727:Sex Characteristics; D014280:Triglycerides / Q000097:blood*
D001798:Blood Proteins; D014280:Triglycerides; C044541:complement C3a, des-Arg-(77)-; D015926:Complement C3a