Effects of alpha-pinene odor in different concentrations on stress-induced hyperthermia in rats.
Stress-induced hyperthermia is observed in animals exposed to stressful conditions. In our previous study, plant-derived fragrances such as green odor and alpha-pinene were shown to suppress this stress response in rats. In the present study, we examined the concentration-dependence of the alpha-pinene effects on stress-induced hyperthermia. Male rats carrying telemetry transmitters were transferred individually to a new cage containing bedding that had been sprayed with 0.3, 0.03, and 0.003% concentrations of alpha-pinene or control solvent. Following transfer to the novel environment, the body temperature increased significantly, and this response was clearly suppressed when the cage was scattered with 0.03% alpha-pinene only. These results suggest that the effect of alpha-pinene on stress-induced hyperthermia can be observed only at a certain concentration.
Akutsu
Hitomi
H
Laboratory of Veterinary Ethology, The University of Tokyo, Japan.
Kikusui
Takefumi
T
Takeuchi
Yukari
Y
Mori
Yuji
Y
D000818:Animals; D000081008:Bicyclic Monoterpenes; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000209:etiology / Q000662:veterinary*; D006799:Housing, Animal; D008297:Male; D039821:Monoterpenes / Q000494:pharmacology*; D009812:Odorants; D051381:Rats; D012376:Rodent Diseases / Q000503:physiopathology*; D012997:Solvents; D013315:Stress, Psychological / Q000503:physiopathology*
D000081008:Bicyclic Monoterpenes; D039821:Monoterpenes; D012997:Solvents; C005451:alpha-pinene