Useful enantioselective bicyclization reactions using an N-protonated chiral oxazaborolidine as catalyst.
[reaction: see text] Nine examples are reported of enantioselective [4 + 2] cycloaddition reactions of achiral, acyclic substrates to form chiral bicyclo[4.3.0]nonane or bicyclo[4.4.0]decane derivatives.
Zhou
Gang
G
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Hu
Qi-Ying
QY
Corey
E J
EJ