title: Ganglioside GM1 mimics: lipophilic substituents improve affinity for cholera toxin.
abstract: Ganglioside GM1 mimics including (R)-2-hydroxy-3-cyclohexylpropionic acid or (R)-2-hydroxy-3-phenylpropionic acid as replacements for NeuAc are stronger cholera toxin binders than the parent ligand 2, which includes (R)-2-hydroxy-propionic acid.
authors.affiliation: Dipartimento di Chimica Organica e Industriale, Universita' di Milano, via Venezian 21, 20133 Milan, Italy.
authors.forename: Daniela
authors.initials: D
authors.lastname: Arosio
authors.forename: Sergio
authors.initials: S
authors.lastname: Baretti
authors.forename: Stefania
authors.initials: S
authors.lastname: Cattaldo
authors.forename: Donatella
authors.initials: D
authors.lastname: Potenza
authors.forename: Anna
authors.initials: A
authors.lastname: Bernardi
mesh_terms: D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002772:Cholera Toxin / Q000737:chemistry*; D005677:G(M1) Ganglioside / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D018716:Molecular Mimicry; D008969:Molecular Sequence Data
chemical_list: D005677:G(M1) Ganglioside; D002772:Cholera Toxin