Tumor pO2 assessments in human xenograft tumors measured by EPR oximetry: location of paramagnetic materials.
Radioantibody immunotherapy (RAIT) is a promising treatment modality but the effectiveness of this targeted low dose radiation varies from tumor to tumor. Since RAIT is an oxygen dependent treatment, baseline pO2 or growth-induced changes in the microenvironment may alter treatment response. In this pilot work we monitored tumor pO2 in untreated human xenograft tumors growing s.c. in nude mice. These data will be used to plan a study of the relationship between the effectiveness of RAIT and tumor pO2. Growth or treatment-induced changes in the microenvironment may alter the tumor pO2 and thus affect the response to therapy but may also affect location and microenvironment of the particulate oxygen sensor. We monitored tumor pO2 during growth and also examined the tumor histological structure overall and in the region of the paramagnetic material in the tumor at the time of necropsy.
O'Hara
Julia A
JA
Department of Diagnostic Radiology, Dartmouth Medical School, Hanover, NH, USA.
Blumenthal
Rosalyn D
RD
Grinberg
Oleg Y
OY
Grinberg
Stalina
S
Wilmot
Carmen
C
Goldenberg
David M
DM
Swartz
Harold M
HM
D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000378:metabolism*; D010092:Oximetry / Q000379:methods*; D010100:Oxygen / Q000378:metabolism*
D010100:Oxygen