[Effects of Peristrophe roxburghiana on blood pressure. NO and ET in renal hypertensive rats].
OBJECTIVE
To observe the effects of Peristrophe roxbrughiana (HSX) on blood pressure, NO, No-synthase and ET in the serum and NO in urine in renal hypertensive rats.


METHODS
The 2K1C(2 kidney 1 clap) hypertensive model rats were used and drugs had been given by ig. for 4 weeks. The blood pressure was measured at the end of the each week. At the end of 4th week, the urine was collected and the concentration of NO in the serum or urine, NO-synthease and ET in the serum were measured.


RESULTS
HSX (H or L dosage) by ig. for 1 week can significantly lower the blood pressure, increase the levels of NO and NO-synthase in the serum and NO in the urine, reduce the concentration of ET in the serum. The effects have lasted for 4 weeks.


CONCLUSIONS
HSX played an important role in the renal hypertensive rats.
Zhuang
Xudan
X
Pharmacy College of Jinan University, Guangzhou 510632.
Lü
Junhua
J
Yang
Wenzhong
W
Yang
Meiling
M
D027901:Acanthaceae / Q000737:chemistry*; D000818:Animals; D000959:Antihypertensive Agents / Q000302:isolation & purification / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D016232:Endothelins / Q000097:blood*; D006978:Hypertension, Renovascular / Q000097:blood* / Q000503:physiopathology; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000097:blood; D052250:Nitric Oxide Synthase Type III; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat