Transformation of the host-selective toxin destruxin B by wild crucifers: probing a detoxification pathway.
The destruxin B detoxification pathway present in Sinapis alba is also present in three unrelated species, Camelina sativa, Capsella bursa-pastoris, and Eruca sativa, suggesting a conservation of this pathway across crucifers. The chemical structure of a destruxin B metabolite, (6'-O-malonyl)hydroxydestruxin B beta-D-glucopyranoside, was also establised. Considering that Camelina sativa and Capsella bursa-pastoris detoxify destruxin B and produce the phytoalexins camalexins, these wild crucifers appear to represent unique and perhaps useful sources of blackleg resistance in strategic plant breeding.
Pedras
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MS
Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK, Canada S7N 5C9. soledade.pedras@usask.ca
Montaut
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Zaharia
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Ward
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D001711:Biotransformation; D019607:Brassicaceae / Q000378:metabolism*; D002250:Carbon Radioisotopes; D047630:Depsipeptides; D005960:Glucosides / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification; D006031:Glycosylation; D006900:Hydroxylation; D015394:Molecular Structure; D009183:Mycotoxins / Q000378:metabolism*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000378:metabolism*; D010936:Plant Extracts / Q000032:analysis / Q000737:chemistry / Q000378:metabolism; D018515:Plant Leaves / Q000737:chemistry / Q000378:metabolism; D012717:Sesquiterpenes; D013729:Terpenes; D013997:Time Factors; D000094162:Phytoalexins
D002250:Carbon Radioisotopes; D047630:Depsipeptides; D005960:Glucosides; D009183:Mycotoxins; D010456:Peptides, Cyclic; D010936:Plant Extracts; D012717:Sesquiterpenes; D013729:Terpenes; C040424:destruxin B; D000094162:Phytoalexins