title: [Natural surfactant preparation in complex therapy of acute respiratory distress syndrome in adults following open-heart surgeries].
abstract: The clinical course and outcomes of cases of acute respiratory distress syndrome (ARDS) as evolved after open-heart surgeries under the conditions of traditional treatment and under the conditions of using the exogenous surfactant drug were comparatively analyzed. A reliably improved oxygenation was registered in the 1st group patients (18 subjects), who received surfactant, yet 24 hours later; while the identical improvement was noted in the 2nd group patients (19 subjects) only in 98 hours. The possibility of respiratory support with FiO2 below 45% was ensured in 15 (83.3%) patients of group 1 and in 10 (52.6%) patients of group 2. Thirteen (72.2%) patients in the 1st group and 9 (47.4%) patients in the 2nd group were transferred to independent breathing. The lethality rate in ARDS with the surfactant therapy made up 33.3%, it was 52.6% in traditional treatment.
authors.forename: A E
authors.initials: AE
authors.lastname: Bautin
authors.forename: G G
authors.initials: GG
authors.lastname: Khubulava
authors.forename: V V
authors.initials: VV
authors.lastname: Osovskikh
authors.forename: O A
authors.initials: OA
authors.lastname: Rozenberg
mesh_terms: D000280:Administration, Inhalation; D001999:Bronchoscopy; D006348:Cardiac Surgical Procedures; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D011663:Pulmonary Surfactants / Q000008:administration & dosage / Q000627:therapeutic use*; D012128:Respiratory Distress Syndrome / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D011663:Pulmonary Surfactants