title: Intraperitoneal chemotherapy with mitoxantrone in malignant ascites.
abstract: A retrospective analysis of intraperitoneal mitoxantrone instillation therapy for malignant ascites in advanced breast and gynecologic pelvic cancers was performed to confirm the efficacy and safety of this therapy. Several smaller phase II trials had suggested good palliative effects. In 143 patients (37 breast cancer and 106 gynecologic cancers), 257 instillations were registered. Response in breast cancer was induced in 49% and in 63% with gynecologic cancer. Severe or life-threatening clinical or laboratory side effects related to intraperitoneal mitoxantrone occurred in 2.7% (clinical) or 1.9% (laboratory) of the 257 instillations. Induction of adverse side effect was dose dependent. Intraperitoneal chemotherapy with mitoxantrone for treatment of malignant ascites in breast cancer and gynecologic malignancy is effective and well tolerated. For this treatment 30 mg mitoxantrone in > or = 1000 mL carrier solution (e.g., saline) is recommended. A minimal concentration of at least 10 micrograms/mL should be achieved.
authors.affiliation: Department of Visceral and Oncologic Surgery, Asklepios Paulinen Klinik and Asklepios, Tumor Center Rhein-Main (ATC), Geisenheimer Str. 10, D 65197 Wiesbaden, Germany. k-h.link.@asklepios.com
authors.forename: K H
authors.initials: KH
authors.lastname: Link
authors.forename: M
authors.initials: M
authors.lastname: Roitman
authors.forename: M
authors.initials: M
authors.lastname: Holtappels
authors.forename: I
authors.initials: I
authors.lastname: Runnebaum
authors.forename: H
authors.initials: H
authors.lastname: Urbanzyk
authors.forename: G
authors.initials: G
authors.lastname: Leder
authors.forename: L
authors.initials: L
authors.lastname: Staib
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001201:Ascites / Q000188:drug therapy / Q000473:pathology; D002277:Carcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D004305:Dose-Response Relationship, Drug; D005260:Female; D005858:Germany; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage*; D009367:Neoplasm Staging; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D008942:Mitoxantrone