Chitin/PLGA blend microspheres as a biodegradable drug delivery system: a new delivery system for protein.
Novel chitin/PLGAs and chitin/PLA based microspheres were developed for the delivery of protein. These biodegradable microspheres were prepared by polymers blending and wet phase-inversion methods. The parameters such as selected non-solvents, temperature of water and ratio of polylactide to polyglycolide were adjusted to improve thermodynamic compatibility of individual polymer (chitin and PLGAs or chitin/PLA), which affects the hydration and degradation properties of the blend microspheres. Triphasic pattern of drug release model is observed from the release of protein from the chitin/PLGAs and chitin/PLA microspheres: the initially fast release (the first phase), the following slow release (the second phase) and the second burst release (the third phase). Formulations of the blends, which are based on the balance among the hydration rate of the chitin phase and degradation of chitin/PLA and PLGA phase, can lead to a controllable release of bovine serum albumin (BSA). In conclusion, such a chitin/PLGA 50/50 microsphere is novel and interesting, and may be used as a protein delivery system.
Mi
Fwu-Long
FL
Division of Applied Chemistry, Department of Applied Science, Chinese Naval Academy, 669 Jiun Shiaw Road, Kaohsiung, Taiwan 813, ROC.
Shyu
Shin-Shing
SS
Lin
Yi-Mei
YM
Wu
Yu-Bey
YB
Peng
Chih-Kang
CK
Tsai
Yi-Hung
YH
D020341:Absorbable Implants; D000327:Adsorption; D002686:Chitin / Q000737:chemistry*; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D008863:Microspheres; D008968:Molecular Conformation; D009038:Motion; D014677:Pharmaceutical Vehicles / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000008:administration & dosage / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000008:administration & dosage* / Q000737:chemistry*; D013499:Surface Properties
D020099:Coated Materials, Biocompatible; D003692:Delayed-Action Preparations; D014677:Pharmaceutical Vehicles; D011108:Polymers; D011506:Proteins; D002686:Chitin; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D012710:Serum Albumin, Bovine; D019344:Lactic Acid