title: [Genetic polymorphism of 8 STR loci on short arm of chromosome 3].
abstract: OBJECTIVE
  To get the genotype and allele frequency distributions of 8 short tandem repeat (STR) loci on chromosome 3p (D3S1297, D3S1489, D3S1266, D3S1568, D3S1289, D3S1300, D3S1285 and D3S3681) in Chinese Han population in Hunan area.
  
  
  METHODS
  Blood samples were collected from the random Han individuals in Hunan and the whole genomic DNA was extracted. STR loci were amplified by multiplex-PCR technique and genotyped by ABI 377 sequencer.
  
  
  RESULTS
  Ninety-one alleles were detected, with frequencies ranging from 0.002 to 0.431, and these alleles constituted 312 genotypes. All the 8 loci met Hardy-Weinberg equilibrium. The statistical analysis of 8 STR loci showed the heterozygosity (H) >or= 0.729, the discrimination power (DP) >or= 0.725, the probabilities of paternity exclusion (PPE) >or= 0.596, and the polymorphic information content (PIC >or= 0.682). The result indicated that there was a significant difference between Han ethnic group and the white and the black.
  
  
  CONCLUSIONS
  These results could serve as valuable data to enrich the Chinese genetic database and play an important role in Chinese population genetic and forensic medical application.
authors.affiliation: Cancer Research Institute, Xiangya Medical School, Central South University, Changsha, Hunan, 410078 PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
authors.forename: Zhao-yang
authors.initials: ZY
authors.lastname: Zeng
authors.forename: Fang
authors.initials: F
authors.lastname: Xiong
authors.forename: Shou-rong
authors.initials: SR
authors.lastname: Shen
authors.forename: Xiao-ling
authors.initials: XL
authors.lastname: Li
authors.forename: Wei-fang
authors.initials: WF
authors.lastname: Li
authors.forename: Rong
authors.initials: R
authors.lastname: Wang
authors.forename: Song-qing
authors.initials: SQ
authors.lastname: Fan
authors.forename: Yi-xin
authors.initials: YX
authors.lastname: Yang
authors.forename: Hou-de
authors.initials: HD
authors.lastname: Zhou
authors.forename: Ming
authors.initials: M
authors.lastname: Zhou
authors.forename: Gui-yuan
authors.initials: GY
authors.lastname: Li
mesh_terms: D000328:Adult; D000483:Alleles; D002681:China; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic