[Transplantation of cerebral neurons into spinal cord for the treatment of paraplegia].
This report shows the experimental results obtained after microsurgical cotransplantation of fetal cerebral tissue and peripheral nerve tissue into previously injured spinal cord. Between 8 and 12 months after surgery, functional recovery is observed in the grafted animals, associated with an increase in muscle mass in the lower extremities. At this time, donor cerebral tissue is integrated into previously injured spinal cord and results in formation of bundles of nerve fibers that emerge from the area of the transplant and surround the spinal cord beneath the lesion. These findings support the possibility of functional recovery after chronic traumatic paraplegia.
Vaquero Crespo
Jesús
J
D000818:Animals; D016380:Brain Tissue Transplantation; D002908:Chronic Disease; D004195:Disease Models, Animal; D016332:Fetal Tissue Transplantation / Q000379:methods; D005500:Follow-Up Studies; D009417:Nerve Tissue / Q000637:transplantation*; D009474:Neurons / Q000637:transplantation*; D010264:Paraplegia / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D010525:Peripheral Nerves; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function; D013119:Spinal Cord Injuries / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D013997:Time Factors