Comparison of glycosyltransferase families using the profile hidden Markov model.
In order to investigate the relationship between glycosyltransferase families and the motif for them, we classified 47 glycosyltransferase families in the CAZy database into four superfamilies, GTS-A, -B, -C, and -D, using a profile Hidden Markov Model method. On the basis of the classification and the similarity between GTS-A and nucleotidylyltransferase family catalyzing the synthesis of nucleotide-sugar, we proposed that ancient oligosaccharide might have been synthesized by the origin of GTS-B whereas the origin of GTS-A might be the gene encoding for synthesis of nucleotide-sugar as the donor and have evolved to glycosyltransferases to catalyze the synthesis of divergent carbohydrates. We also suggested that the divergent evolution of each superfamily in the corresponding subcellular component has increased the complexities of eukaryotic carbohydrate structure.
Kikuchi
Norihiro
N
Glycogene Function Team, Research Center for Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory C-2, 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, Japan.
Kwon
Yeon-Dae
YD
Gotoh
Masanori
M
Narimatsu
Hisashi
H
D000595:Amino Acid Sequence; D002241:Carbohydrates / Q000032:analysis; D006031:Glycosylation; D016695:Glycosyltransferases / Q000032:analysis / Q000145:classification* / Q000378:metabolism; D008390:Markov Chains; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D002241:Carbohydrates; D016695:Glycosyltransferases