Synthesis and biological evaluation of a series of new cyclohexenyl nucleosides.
A series of cyclohexenyl nucleosides (1-8) were successfully prepared with moderate yield and their cytotoxicity and antiviral activity were investigated. Among the eight new compounds, only the diaminopurine analogue 8 showed pronounced activity against HSV-1, HSV-2.
Gu
Ping
P
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.
Morral
Jordi
J
Wang
Jing
J
Rozenski
Jef
J
Busson
Roger
R
Van Aerschot
Arthur
A
De Clercq
Erik
E
Herdewijn
Piet
P
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003510:Cyclohexanes; D003587:Cytomegalovirus / Q000187:drug effects; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D014645:Herpesvirus 3, Human / Q000187:drug effects; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000998:Antiviral Agents; D003510:Cyclohexanes; D003603:Cytotoxins; D009705:Nucleosides