Mast cell-IgE-and mast cell-structural cell interactions in allergic airway disease.
Allergic diseases like atopic rhinitis, bronchial asthma, and urticaria are prevalent and on the rise. Mast cells are known to play a central role in the immediate phase reaction of allergic diseases through the IgE-mediated release of a variety of chemical mediators like histamine, leukotrienes, and prostaglandins. On the other hand, T lymphocytes, basophils and eosinophils are thought to be responsible in inducing the late phase response. Yet, recent studies show that the mast cell cannot be simplistically assigned a role in the immediate phase allergic response, and that this cell plays a crucial role in ongoing allergic inflammation, including the development of hyper-responsiveness. In the present article, the author will try to discuss the integrated roles of mast cells in IgE-mediated allergic inflammation with specific emphasis on the roles of mast cell-IgE networking and mast cell-structural cell interactions in the late phase allergic response and chronic allergic inflammation.
Pawankar
Ruby
R
Department of Otolaryngology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. susan@nms.ac.jp
Yamagishi
Shigeo
S
Takizawa
Ryuta
R
Yagi
Toshiaki
T
D001249:Asthma / Q000473:pathology; D015815:Cell Adhesion Molecules; D016207:Cytokines / Q000502:physiology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000473:pathology*; D007073:Immunoglobulin E / Q000502:physiology*; D008407:Mast Cells / Q000276:immunology* / Q000473:pathology*; D006255:Rhinitis, Allergic, Seasonal / Q000473:pathology
D015815:Cell Adhesion Molecules; D016207:Cytokines; D007073:Immunoglobulin E