[Computer-assisted vaccine design].
With the modern molecular biology techniques, it has been possible to detect, isolate and clone biological macromolecules, which could be used as immunogenes in artificial vaccine constructs. In the post-genomic era, the prospective immunogenic components are searched using bionformatic tools and proteomic technologies. Today it is quite realistic to combine the artificial vaccine constructs from the preselected molecular components. Existing computational methods are able to detect the potential immunogenes in genomic sequences, predict their characteristics and subcellular location. The set of methods is designed to predict the T- and B-epitopes that can be used as components of minimal vaccine constructs. The variety of systems for production and delivery of vaccines are developed and tested. These include transgenic plants, bacterial and viral vectors, DNA molecules etc. Several informational resources provide free access to molecular immunology data and deliver services on prediction of antigenic features. Several artificial vaccines have already been launched, but much more preparations are under preclinical and clinical trials. Computer-aided design of vaccines may significantly decrease time and costs required for their development. Modern bioinformatic technologies are now employed for discovery of more effective and potent vaccine.
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Institute of Biomedical Chemistry, Rus. Acad. Med. Sci., 10, Pogodinskaya str., Moscow, 119121, Russia. boris@ibmh.msk.su
Poroĭkov
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Olenina
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Kolesanova
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Archakov
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D000818:Animals; D003198:Computer Simulation; D015195:Drug Design; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D016678:Genome; D006801:Humans; D020407:Internet; D014614:Vaccines, Synthetic / Q000737:chemistry / Q000235:genetics / Q000276:immunology
D000939:Epitopes; D014614:Vaccines, Synthetic