title: Imidazolethyl-phosphoramidate alpha-oligonucleotides.
abstract: Alpha-ODNs conjugated to imidazole groups via phosphoramidate internucleosidic linkages were synthesized. The presence of the imidazolethyl-phosphoramidate linkage improved the affinity of alpha-ODNs for their nucleic acid targets.
authors.affiliation: Laboratoire de Chimie Organique Biomoléculaire de Synthèse, Université de Montpellier II, UMR 5625 CNRS-UMII, Montpellier, France.
authors.forename: T
authors.initials: T
authors.lastname: Michel
authors.forename: L
authors.initials: L
authors.lastname: Mouls
authors.forename: F
authors.initials: F
authors.lastname: Debart
authors.forename: J J
authors.initials: JJ
authors.lastname: Vasseur
mesh_terms: D000577:Amides; D001483:Base Sequence; D001665:Binding Sites; D007093:Imidazoles; D009693:Nucleic Acid Hybridization; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D010756:Phosphoric Acids
chemical_list: D000577:Amides; D007093:Imidazoles; D009838:Oligodeoxyribonucleotides; D010756:Phosphoric Acids; C011067:phosphoramidic acid