title: Identification of potent and novel small-molecule inhibitors of caspase-3.
abstract: The design and synthesis of a series of novel, reversible, small molecule inhibitors of caspase-3 are described.
authors.affiliation: Sunesis Pharmaceuticals, Inc., 341 Oyster Point Boulevard, South San Francisco, CA 94080, USA. dallen@sunesis.com
authors.forename: Darin A
authors.initials: DA
authors.lastname: Allen
authors.forename: Phuongly
authors.initials: P
authors.lastname: Pham
authors.forename: Ingrid C
authors.initials: IC
authors.lastname: Choong
authors.forename: Bruce
authors.initials: B
authors.lastname: Fahr
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Burdett
authors.forename: Willard
authors.initials: W
authors.lastname: Lew
authors.forename: Warren L
authors.initials: WL
authors.lastname: DeLano
authors.forename: Eric M
authors.initials: EM
authors.lastname: Gordon
authors.forename: Joni W
authors.initials: JW
authors.lastname: Lam
authors.forename: Tom
authors.initials: T
authors.lastname: O'Brien
authors.forename: Dennis
authors.initials: D
authors.lastname: Lee
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D053148:Caspase 3; D061945:Caspase Inhibitors; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007659:Ketones / Q000737:chemistry; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000447:Aldehydes; D061945:Caspase Inhibitors; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D007659:Ketones; D053148:Caspase 3