title: Molecular recognition of quadruplex DNA by quinacridine derivatives.
abstract: The interaction of monomeric and dimeric quinacridines with quadruplex DNA has been investigated using a variety of biophysical methods. Both series of compounds were shown to exhibit a high affinity for the G4 conformation with two equivalent binding sites. As shown from the SPR and dialysis experiments the macrocyclic dimer appears more selective than its monomeric counterpart.
authors.affiliation: LCIM, Collège de France, Paris, France. mp.teulade-fichou@college-de-france.fr
authors.forename: M P
authors.initials: MP
authors.lastname: Teulade-Fichou
authors.forename: C
authors.initials: C
authors.lastname: Hounsou
authors.forename: L
authors.initials: L
authors.lastname: Guittat
authors.forename: J L
authors.initials: JL
authors.lastname: Mergny
authors.forename: P
authors.initials: P
authors.lastname: Alberti
authors.forename: C
authors.initials: C
authors.lastname: Carrasco
authors.forename: C
authors.initials: C
authors.lastname: Bailly
authors.forename: J M
authors.initials: JM
authors.lastname: Lehn
authors.forename: W D
authors.initials: WD
authors.lastname: Wilson
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D011796:Quinacrine
chemical_list: D009838:Oligodeoxyribonucleotides; D004247:DNA; D011796:Quinacrine