title: Human skeletal muscle energy metabolism: when a physiological model promotes the search for new technologies.
abstract: The idea that muscle function and, in fact, the function of all living tissues may be described by physical laws appeared in the second half of the 19th century. During this period, Helmoltz (Uber die Erhaltung der Kraft, 1847) showed that the principle of energy conservation may be applied to living systems. In the field of exercise physiology, this idea has been subsequently developed by Rodolfo Margaria's (1901-1983) School and the mathematical formalization of the theory has succeeded in the bioenergetic model. During the last 20 years methodical and critical study of the bioenergetic model has been carried out by Paolo Cerretelli, one of the most important heirs of Rodolfo Margaria's School. Original results and technological developments have been generated by his activity and many young scientists have been educated in this approach. The present paper wants to present the modern history of the bioenergetic model and is dedicated to Paolo Cerretelli on the occasion of his seventieth birthday.
authors.affiliation: Dept of Radiology, Département de Physiologie, Centre Médical Universitaire, rue Michel Servet 1, 1211 Genève 4, Geneva, Switzerland. Tiziano.Binzoni@medecine.unige.ch
authors.forename: Tiziano
authors.initials: T
authors.lastname: Binzoni
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D006358:Hot Temperature; D006801:Humans; D006859:Hydrogen / Q000737:chemistry; D019344:Lactic Acid / Q000378:metabolism; D017078:Laser-Doppler Flowmetry; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000098:blood supply / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus / Q000737:chemistry; D012129:Respiratory Function Tests / Q000379:methods*; D019265:Spectroscopy, Near-Infrared; D013696:Temperature
chemical_list: D010725:Phosphocreatine; D010758:Phosphorus; D019344:Lactic Acid; D006859:Hydrogen; D000255:Adenosine Triphosphate; D010100:Oxygen