Oxyntomodulin suppresses appetite and reduces food intake in humans.
Oxyntomodulin (OXM) is released from the gut postprandially, in proportion to energy intake, and circulating levels of OXM are elevated in several conditions associated with anorexia. Central injection of OXM reduces food intake and weight gain in rodents, suggesting that OXM signals food ingestion to hypothalamic appetite-regulating circuits. We investigated the effect of iv OXM (3.0 pmol/kg.min) on appetite and food intake in 13 healthy subjects (body mass index, 22.5 +/- 0.9 kg/m(2)) in a randomized, double-blind, placebo-controlled, cross-over study. Infusion of OXM significantly reduced ad libitum energy intake at a buffet meal (mean decrease, 19.3 +/- 5.6%; P < 0.01) and caused a significant reduction in scores for hunger. In addition, cumulative 12-h energy intake was significantly reduced by infusion of OXM (mean decrease, 11.3 +/- 6.2%; P < 0.05). OXM did not cause nausea or affect food palatability. Preprandial levels of the appetite-stimulatory hormone, ghrelin, were significantly suppressed by OXM (mean reduction, 44 +/- 10% of postprandial decrease; P < 0.0001). Elevated levels of endogenous OXM associated with disorders of the gastrointestinal tract may contribute to anorexia.
Cohen
Mark A
MA
Department of Metabolic Medicine, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom W12 0NN. s.bloom@imperial.ac.uk
Ellis
Sandra M
SM
Le Roux
Carel W
CW
Batterham
Rachel L
RL
Park
Adrian
A
Patterson
Michael
M
Frost
Gary S
GS
Ghatei
Mohammad A
MA
Bloom
Stephen R
SR
D000328:Adult; D001066:Appetite / Q000187:drug effects*; D001067:Appetite Depressants / Q000008:administration & dosage* / Q000493:pharmacokinetics; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects; D005260:Female; D054439:Ghrelin; D004763:Glucagon-Like Peptides / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D006728:Hormones / Q000097:blood; D006801:Humans; D008297:Male; D053772:Oxyntomodulin; D036361:Peptide Hormones / Q000097:blood
D001067:Appetite Depressants; D054439:Ghrelin; D006728:Hormones; D053772:Oxyntomodulin; D036361:Peptide Hormones; D004763:Glucagon-Like Peptides