title: A novel and convenient method for the synthesis of free 5'-thiol modified oligonucleotides.
abstract: The synthesis of free 5'-thiol-modified oligonucleotides using a 4,4',4''-trimethoxytrityl (TMTr)-protected linker and standard Poly-Pak purification has been described.
authors.affiliation: Nucleic Acids Laboratory, Department of Medicinal Chemistry, University of Szeged, Szeged, Hungary. kupi@ovrisc.mdche.u-szeged.hu
authors.forename: Z
authors.initials: Z
authors.lastname: Kupihár
authors.forename: G
authors.initials: G
authors.lastname: Kovács
authors.forename: Z
authors.initials: Z
authors.lastname: Kele
authors.forename: Z
authors.initials: Z
authors.lastname: Darula
authors.forename: L
authors.initials: L
authors.lastname: Kovács
mesh_terms: D001483:Base Sequence; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013438:Sulfhydryl Compounds
chemical_list: D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D013438:Sulfhydryl Compounds