Myrsinoic acid E, an anti-inflammatory compound from Myrsine seguinii.
The methanolic extract of Myrsine seguinii yielded the novel anti-inflammatory compound, myrsinoic acid E (1), whose structure was elucidated to be 3,5-digeranyl-4-hydroxy benzoic acid. We synthesized 1- and its 3,5-diprenyl (2) and 3,5-difarnesyl analogues (3). Compounds 1-3 suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation of mouse ears by 59%, 14%, and 69% at a dose of 1.4 micromol.
Makabe
Hidefumi
H
Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University, Kami-ina, Nagano, Japan. makabeh@gipmc.shinshu-u.ac.jp
Miyazaki
Shintaro
S
Kamo
Tsunashi
T
Hirota
Mitsuru
M
D000475:Alkenes / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology*; D001565:Benzoates / Q000737:chemistry / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D051379:Mice; D010226:Parabens / Q000737:chemistry* / Q000494:pharmacology*; D029623:Primulaceae / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
D000475:Alkenes; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001565:Benzoates; D010226:Parabens; D013729:Terpenes; C486871:myrsinoic acid E; D013755:Tetradecanoylphorbol Acetate