title: Cell death during lymphocyte development and activation.
abstract: The development and homeostasis of the immune system requires an exquisite balance between cell proliferation and cell death. In this review, we discuss several in vivo and in vitro models that have been developed to help understand the importance of apoptosis during B and T cell development and activation.
authors.affiliation: Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, UAM Campus de Cantoblanco, E-28049 Madrid, Spain.
authors.forename: Ignacio Moreno
authors.initials: IM
authors.lastname: de Alborán
authors.forename: María S
authors.initials: MS
authors.lastname: Robles
authors.forename: Alexandra
authors.initials: A
authors.lastname: Bras
authors.forename: Esther
authors.initials: E
authors.lastname: Baena
authors.forename: Carlos
authors.initials: C
authors.lastname: Martínez-A
mesh_terms: D000818:Animals; D017209:Apoptosis; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D002454:Cell Differentiation; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism