[Use of indocyanine green for photodynamic therapy of choroidal melanoma--preliminary report].
OBJECTIVE
To evaluate the usefulness of indocyanine green (ICG) in the photodynamic therapy (iPDT) of choroidal melanoma.


METHODS
Thirty eight patients with choroidal melanoma were treated with iPDT. Tumor thickness ranged from 2.6 to 4.1 mm in ultrasonography. Before iPDT Ruthenium-106 plaques were used in 18 cases, in 6 cases with additional transpupillary thermotherapy ("sandwich method"), and Iodine-125 plaques in 3 cases. In 11 eyes the iPDT was the only performed treatment. Therapy was performed with 810 nm diode laser after intravenous injection of 25 mg solution of indocyanine green. Six months after iPDT ophthalmological examination was performed with ultrasonography and ICGA images evaluation.


RESULTS
The baseline ICG study showed pathological intrinsic vasculature in all examined cases. Six months after iPDT changes in microcirculation, as well as significant decrease of tumors thickness in ultrasonography (mean 38%), were detected in all cases. Complete regression of intrinsic vessels was demonstrated by ICGA in 26 cases, and partial regression of pathological vascularization was found in 12 patients.


CONCLUSIONS
Our preliminary study suggests, that ICG mediated iPDT can be a new and promising way, to treat choroidal melanoma.
Kubicka-Trzaska
Agnieszka
A
Katedry i Kliniki Okulistyki Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
Starzycka
Maria
M
Romanowska-Dixon
Bozena
B
Morawski
Krzysztof
K
D000328:Adult; D000368:Aged; D002829:Choroid / Q000098:blood supply / Q000000981:diagnostic imaging; D002830:Choroid Neoplasms / Q000098:blood supply / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D007208:Indocyanine Green / Q000627:therapeutic use*; D008297:Male; D008545:Melanoma / Q000098:blood supply / Q000175:diagnosis / Q000188:drug therapy*; D008833:Microcirculation; D008875:Middle Aged; D010778:Photochemotherapy / Q000379:methods*; D016896:Treatment Outcome; D014463:Ultrasonography
D007208:Indocyanine Green