Positive and negative selection of T cell repertoires during differentiation in allogeneic bone marrow chimeras.
T cells acquire immune functions during expansion and differentiation in the thymus. Mature T cells respond to peptide antigens (Ag) derived from foreign proteins when these peptide Ag are presented on the self major histocompatibility complex (MHC) molecules but not on allo-MHC. This is termed self-MHC restriction. On the other hand, T cells do not induce aggressive responses to self Ag (self-tolerance). Self-MHC restriction and self-tolerance are not genetically determined but acquired a posteriori by positive and negative selection in the thymus in harmony with the functional maturation. Allogeneic bone marrow (BM) chimera systems have been a useful strategy to elucidate mechanisms underlying positive and negative selection. In this communication, the contribution of BM chimera systems to the investigation of the world of T-ology is discussed.
Onoé
Kazunori
K
Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan. kazunori@imm.hokudai.ac.jp
Gotohda
Toshihiko
T
Nishihori
Hiroki
H
Aranami
Toshimasa
T
Iwabuchi
Chikako
C
Iclozan
Cristina
C
Morohashi
Taiki
T
Ogasawara
Kazumasa
K
Good
Robert A
RA
Iwabuchi
Kazuya
K
D000595:Amino Acid Sequence; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology*; D017637:Clonal Deletion / Q000276:immunology; D010856:Columbidae; D045304:Cytochromes c / Q000235:genetics / Q000276:immunology; D005434:Flow Cytometry; D006087:Graft vs Host Reaction / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008212:Lymphocyte Depletion; D008285:Major Histocompatibility Complex / Q000276:immunology; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D018448:Models, Immunological; D010455:Peptides / Q000235:genetics / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000737:chemistry / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology; D018183:Transplantation Chimera / Q000276:immunology*; D014184:Transplantation, Homologous
D000945:Antigens, Differentiation, T-Lymphocyte; D010455:Peptides; D011948:Receptors, Antigen, T-Cell; D045304:Cytochromes c