title: Two secondary malignancies after radiotherapy for seminoma: case report and review of the literature.
abstract: We report a case of a 50-year-old man with two synchronous second malignancies 25 years after orchiectomy and adjuvant radiotherapy for seminoma. An annual health examination revealed an elevated prostate-specific antigen level. A biopsy was performed revealing Gleason score 9 adenocarcinoma of the prostate. Computed tomography of the abdomen revealed a 2-cm solid mass in the right kidney consistent with renal cell carcinoma. Both of these lesions were within the nonstandard radiation field for seminoma with which this patient was treated. Second malignancies, including prostate cancer, are a very uncommon occurrence but an important consideration in long-term survivors of seminoma treated with radiotherapy.
authors.affiliation: Department of Radiation Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Hughes
authors.forename: Alice
authors.initials: A
authors.lastname: Wang
authors.forename: Theodore L
authors.initials: TL
authors.lastname: DeWeese
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology*; D002292:Carcinoma, Renal Cell / Q000209:etiology*; D003131:Combined Modality Therapy; D006801:Humans; D007680:Kidney Neoplasms / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000209:etiology*; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000209:etiology*; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects*; D012306:Risk; D018239:Seminoma / Q000532:radiotherapy* / Q000601:surgery; D017741:Survivors; D013736:Testicular Neoplasms / Q000532:radiotherapy* / Q000601:surgery