[Nitric oxide activity in women with intrauterine growth restriction treated by L-arginine].
OBJECTIVE
The aim of the study was to find correlation between the nitric oxide metabolites such nitrite in healthy pregnant women and in intrauterine growth restriction. The decrease of nitric oxide metabolites production may be linked to endothelial cells deficiency.


METHODS
High risk of destruction of biological function of cells by free radical processes is observed in IUGR. It depends on NO deficiency and lipid peroxidation processes. Concentration of NO metabolites measured in pregnancy can show the correlation between oxidative stress and NO metabolism.


METHODS
The study was undertaken in Medical University in Lodz in 2000-2002. The study group consisted of women with IUGR, the control one of healthy women. The group of IUGR was treated with L-arginine-nitric oxide precursor and acetylsalicylic acid. The nitrite activity was measured by Oxis kit, in Grees reaction and was expressed in mumol/l.


RESULTS
In group of IUGR low concentration of NO metabolites was observed before treatment. After 20 days of treatment the concentration decreased. In the control group the value was higher than IUGR group/significant difference/and after 20 days of observation decreased as well.


CONCLUSIONS
We found the difference between the two groups and the decrease of NO metabolite concentration in the course of pregnancy.
Karowicz-Bilińska
Agata
A
Kliniki Patologii Ciazy Instytutu Ginekologii i Połoznictwa Uniwersytetu Medycznego w Łodzi.
Kowalska-Koprek
Urszula
U
Suzin
Jacek
J
Sieroszewski
Piotr
P
D000328:Adult; D001120:Arginine / Q000008:administration & dosage* / Q000494:pharmacology*; D016022:Case-Control Studies; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005317:Fetal Growth Retardation / Q000097:blood* / Q000188:drug therapy* / Q000517:prevention & control; D006801:Humans; D009569:Nitric Oxide / Q000097:blood*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D011247:Pregnancy; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome
D009569:Nitric Oxide; D001120:Arginine; D019001:Nitric Oxide Synthase