title: Urinary modified nucleosides as tumor markers.
abstract: Extracts of urinary nucleosides have been sequentially purified and examined by mass spectrometric analysis. Seventeen modified nucleosides have been unequivocally identified and a further five provisionally identified. While several nucleosides were found only in a small number of extracts, the occurrence and levels of others were found to correlate with the tumour type and stage.
authors.affiliation: Biochemistry Group, School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea, UK.
authors.forename: E
authors.initials: E
authors.lastname: Dudley
authors.forename: F
authors.initials: F
authors.lastname: Lemiere
authors.forename: W
authors.initials: W
authors.lastname: Van Dongen
authors.forename: E
authors.initials: E
authors.lastname: Esmans
authors.forename: A M M
authors.initials: AM
authors.lastname: El-Sharkawi
authors.forename: D E
authors.initials: DE
authors.lastname: Games
authors.forename: A G
authors.initials: AG
authors.lastname: Brenton
authors.forename: R P
authors.initials: RP
authors.lastname: Newton
mesh_terms: D014408:Biomarkers, Tumor / Q000737:chemistry / Q000302:isolation & purification / Q000652:urine*; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D013058:Mass Spectrometry; D009367:Neoplasm Staging; D009369:Neoplasms / Q000473:pathology / Q000652:urine; D009705:Nucleosides / Q000737:chemistry / Q000302:isolation & purification / Q000652:urine*
chemical_list: D014408:Biomarkers, Tumor; D009705:Nucleosides