title: Intraoperative ultrasonography guidance is accurate and efficient according to results in 100 breast cancer patients.
abstract: BACKGROUND
  The frequency of nonpalpable breast cancer has doubled in the last 10 years. Surgical use of high quality portable ultrasound units has made it possible to evaluate the time-saving method of intraoperative ultrasonography localization.
  
  
  METHODS
  Ultrasonography localization in the operating room immediately prior to definitive surgery was performed by the surgeon. All tissue underwent specimen mammography and ink orientation. The presence of negative margins, the closest margins, the need for reexcision, and the cosmetic result were examined for each patient.
  
  
  RESULTS
  Ultrasonography correctly localized all breast cancers at surgery (100% sensitivity). Negative margins for invasive carcinoma were found in 90% of patients. Negative margins were at least 10 mm in 27%, at least 5 mm in 62%, and at least 1 mm in 90%. Positive margins were due to the presence of noncalcified ductal carcinoma in-situ (4 of 10) or multifocal invasive disease (6 of 10) noted at final histology. Reexcisions were performed in 9% of patients.
  
  
  CONCLUSIONS
  Surgical use of intraoperative ultrasonography for localization of breast cancer is accurate and efficient. Ultrasonography localization is easier on the patient, is time and cost efficient, and convenient to schedule. Surgeons should embrace this new skill and utilize this tool whenever a nonpalpable breast cancer can be seen with ultrasonography.
authors.affiliation: Department of Surgery, University of Washington, Seattle, WA, USA. breastcare@aol.com
authors.forename: Cary S
authors.initials: CS
authors.lastname: Kaufman
authors.forename: Leslie
authors.initials: L
authors.lastname: Jacobson
authors.forename: Barbara
authors.initials: B
authors.lastname: Bachman
authors.forename: Lauren B
authors.initials: LB
authors.lastname: Kaufman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000000981:diagnostic imaging / Q000601:surgery; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008875:Middle Aged; D016217:Ultrasonography, Mammary