title: Insect peptide hormones: a selective review of their physiology and potential application for pest control.
abstract: Our knowledge on primary structure, synthesis, release, receptor binding, structure-activity relationships, mode of action and degradation of, mainly, neuropeptides from insects has increased dramatically during the last 10 years or so. Here, five case studies are presented, which deal selectively with effects on: reproduction (trypsin modulating oostatic factor in mosquito); energy metabolism, locomotion and the immune system (adipokinetic hormones); water and ion balance, and feeding behaviour (diuretic hormones, kinins, sulfakinins); sex attraction (pheromone biosynthesis activating neuropeptide); and growth and development, and muscle activity (allatostatins). The literature is reviewed in the context of how the knowledge on neuropeptides has been and can be used for the design of novel, safe and selective compounds to control pest insects in the foreseeable future.
authors.affiliation: Zoology Department, University of Cape Town, Rondebosch, South Africa. ggade@botzoo.uct.ac.za
authors.forename: Gerd
authors.initials: G
authors.lastname: Gäde
authors.forename: Graham J
authors.initials: GJ
authors.lastname: Goldsworthy
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D007300:Insect Control / Q000379:methods; D007301:Insect Hormones / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D007313:Insecta / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000235:genetics* / Q000378:metabolism* / Q000494:pharmacology; D012098:Reproduction / Q000187:drug effects
chemical_list: D007301:Insect Hormones; D009479:Neuropeptides