title: Oral misoprostol for premature rupture of membranes at term.
abstract: OBJECTIVE
  The study was undertaken to compare the efficacy, safety, and maternal satisfaction of oral misoprostol and intravenous oxytocin for labor induction in women with premature rupture of membranes at term.
  
  
  METHODS
  One hundred five women were stratified by parity and randomly assigned to oral misoprostol 75 microg every 4 hours as needed to establish labor or to intravenous oxytocin.
  
  
  RESULTS
  The induction to vaginal delivery time with oral misoprostol was 737 (+/-426) minutes compared with 573 (+/-318) minutes with oxytocin (P=.04). The incidence of hyperstimulation was lower in the misoprostol group (6.0% vs 27.1%, P=.005). Women were more likely to be very satisfied with their care in the misoprostol group (86.0% vs 63.4%, P=.02).
  
  
  CONCLUSIONS
  In women at term with premature rupture of membranes, oral misoprostol resulted in a longer induction to vaginal delivery interval but increased maternal satisfaction and less hyperstimulation compared with intravenous oxytocin. Further research is needed to assess uncommon neonatal and maternal outcomes.
authors.affiliation: Department of Obstetrics and Gynecology, Memorial University of Newfoundland, St. John's, Canada. hcc.cranj@hccsj.nf.ca
authors.forename: Joan M G
authors.initials: JM
authors.lastname: Crane
authors.forename: Tina
authors.initials: T
authors.lastname: Delaney
authors.forename: Donna
authors.initials: D
authors.lastname: Hutchens
mesh_terms: D000328:Adult; D005260:Female; D005322:Premature Rupture of Fetal Membranes; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D016015:Logistic Models; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects; D010120:Oxytocics / Q000008:administration & dosage*; D010121:Oxytocin / Q000008:administration & dosage; D017060:Patient Satisfaction; D011247:Pregnancy; D013997:Time Factors
chemical_list: D010120:Oxytocics; D016595:Misoprostol; D010121:Oxytocin