title: Pediatric invasive pneumococcal disease in a teaching hospital in Bangkok.
abstract: BACKGROUND
  Increased problems with drug-resistant Streptococcus pneumoniae (SP) and the dearth of epidemiologic and clinical information on invasive pneumococcal disease in children in Asia formed the basis for this study.
  
  
  METHODS
  A periodic retrospective review of the records of 0-15-year-old patients was conducted at a teaching hospital in Bangkok, during 1971-2000.
  
  
  RESULTS
  Infections with penicillin-non-susceptible SP (PNSSP) strains rapidly increased after they first appeared in 1988, and they accounted for 71% (29/41) of the total cases during 1996-2000. Of 137 patients, 74% were <60 months old, and 66% had an underlying condition. Infections included: bacteremia without focus 51; pneumonia 38; meningitis 35; peritonitis 13; and bone/joint infection 2. Two patients had two foci of infection. Eight of 10 episodes in patients with AIDS were bacteremic pneumonia. Median ages (range) in months for patients with and without an underlying condition were 24 (1-174) and 10 (0-160); and for the patients without an underlying condition they were: pneumonia 23 (4-156); bacteremia without focus 12 (0-160); and meningitis 7 (2-156). Case-fatality rates were 18% and 2% for patients with and without an underlying condition. The study also examined factors associated with PNSSP infection and death. During 1991-2000, 74% (43/58) of the total cases occurred from November to April, which are dry months.
  
  
  CONCLUSIONS
  This study population contained a high proportion with both an underlying condition and infection with PNSSP, and a moderately low proportion with bacteremia without focus. The disease was two to three times more common in dry months than in rainy months.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Sayomporn
authors.initials: S
authors.lastname: Sirinavin
authors.forename: Malai
authors.initials: M
authors.lastname: Vorachit
authors.forename: Ammarin
authors.initials: A
authors.lastname: Thakkinstian
authors.forename: Sirichai
authors.initials: S
authors.lastname: Hongsanguensri
authors.forename: Panida
authors.initials: P
authors.lastname: Wittayawongsruji
mesh_terms: D000293:Adolescent; D017677:Age Distribution; D016470:Bacteremia; D002648:Child; D002675:Child, Preschool; D006784:Hospitals, Teaching; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010372:Pediatrics; D010403:Penicillin Resistance; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D012189:Retrospective Studies; D012621:Seasons; D013296:Streptococcus pneumoniae / Q000302:isolation & purification