Discrepancy between [18F]fluorodeoxyglucose and 11C-methionine positron emission tomography findings in Sturge-Weber syndrome--case report.
Cerebral blood flow and metabolism were evaluated in an adult with symptomatic intractable epilepsy and Sturge-Weber syndrome (SWS) manifesting as angiomas in the left cerebral hemisphere. 99mTc-ethylcysteinate dimer single photon emission computed tomography detected reduced blood flow in the entire left cerebral hemisphere, and [18F]fluorodeoxyglucose positron emission tomography (PET) showed decreased glucose metabolism in the left cerebral hemisphere. These findings indicated hypofunction of the left cerebral hemisphere, which caused the right hemiparesis. 11C-methionine (11C-Met) PET revealed high 11C-Met accumulation in the angiomas in the left cerebral hemisphere. Immunostaining for glial fibrillary acidic protein showed positive reaction in the lesions. Gliosis is a likely mechanism for the 11C-Met accumulation, which is possibly associated with progressive calcification in the angiomas and retarded growth of patients with SWS occurring over many years.
Ichinose
Tsutomu
T
Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.
Tsuyuguchi
Naohiro
N
Morino
Michiharu
M
Sunada
Ichiro
I
Ohata
Kenji
K
Takami
Toshihiro
T
Shimonishi
Yoshihiro
Y
Kawabe
Joji
J
Shiomi
Susumu
S
Hara
Mitsuhiro
M
D000328:Adult; D002250:Carbon Radioisotopes; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008715:Methionine; D019275:Radiopharmaceuticals; D013341:Sturge-Weber Syndrome / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed
D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D008715:Methionine