title: Computer-aided tissue engineering: overview, scope and challenges.
abstract: Advances in computer-aided technology and its application with biology, engineering and information science to tissue engineering have evolved a new field of computer-aided tissue engineering (CATE). This emerging field encompasses computer-aided design (CAD), image processing, manufacturing and solid free-form fabrication (SFF) for modelling, designing, simulation and manufacturing of biological tissue and organ substitutes. The present Review describes some salient advances in this field, particularly in computer-aided tissue modeling, computer-aided tissue informatics and computer-aided tissue scaffold design and fabrication. Methodologies of development of CATE modelling from high-resolution non-invasive imaging and image-based three-dimensional reconstruction, and various reconstructive techniques for CAD-based tissue modelling generation will be described. The latest development in SFF to tissue engineering and a framework of bio-blueprint modelling for three-dimensional cell and organ printing will also be introduced.
authors.affiliation: Laboratory for Computer-Aided Tissue Engineering, Department of Mechanical Engineering and Mechanics, College of Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA. sunwei@drexel.edu
authors.forename: Wei
authors.initials: W
authors.lastname: Sun
authors.forename: Andrew
authors.initials: A
authors.lastname: Darling
authors.forename: Binil
authors.initials: B
authors.lastname: Starly
authors.forename: Jae
authors.initials: J
authors.lastname: Nam
mesh_terms: D000818:Animals; D001187:Artificial Organs; D001672:Biocompatible Materials / Q000138:chemical synthesis; D001808:Blood Vessels / Q000502:physiology; D017076:Computer-Aided Design; D006801:Humans; D008846:Micromanipulation; D008954:Models, Biological; D023822:Tissue Engineering / Q000379:methods*; D016378:Tissue Transplantation / Q000379:methods*
chemical_list: D001672:Biocompatible Materials