title: Relationship between glutathione S-transferase P1 polymorphism and bronchial asthma and atopic dermatitis.
abstract: We determined the prevalence of GSTP1-Ile105 and GSTP1-Val105 alleles in patients with bronchial asthma and atopic dermatitis and healthy children of 2 groups (randomized and nonatopic control). The GSTP1-Ile105/Val105 genotype determines the resistance to atopic dermatitis (odds ratio=0.51; 95% confidence interval: 0.28-0.92; p=0.023). However, both homozygotes are at high risk of developing atopic dermatitis (near-significant differences).
authors.affiliation: Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. drugsmet@.cyber.ma.nsc.ru
authors.forename: O G
authors.initials: OG
authors.lastname: Safronova
authors.forename: V A
authors.initials: VA
authors.lastname: Vavilin
authors.forename: A A
authors.initials: AA
authors.lastname: Lyapunova
authors.forename: S I
authors.initials: SI
authors.lastname: Makarova
authors.forename: V V
authors.initials: VV
authors.lastname: Lyakhovich
authors.forename: L F
authors.initials: LF
authors.lastname: Kaznacheeva
authors.forename: N A
authors.initials: NA
authors.lastname: Manankin
authors.forename: O A
authors.initials: OA
authors.lastname: Batychko
authors.forename: S M
authors.initials: SM
authors.lastname: Gavalov
mesh_terms: D000483:Alleles; D001249:Asthma / Q000235:genetics*; D002648:Child; D003876:Dermatitis, Atopic / Q000235:genetics*; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D007532:Isoleucine / Q000737:chemistry; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012306:Risk; D012426:Russia; D014633:Valine / Q000737:chemistry; D015262:Xenobiotics / Q000494:pharmacology
chemical_list: D015262:Xenobiotics; D007532:Isoleucine; D005982:Glutathione Transferase; D014633:Valine