title: Correlation between the Banff 97 classification of renal allograft biopsies and clinical outcome.
abstract: The 1997 fourth Banff meeting revised the consensus for describing transplant biopsies. We have conducted a retrospective analysis of biopsies correlated between the Banff 97 classification and clinical outcome. The patients ( n=149), who had a total of 404 biopsy-proven rejections, were assessed and the biopsies taken from these patients were re-examined and classified according to the Banff 97 classification. Morphological changes in the glomeruli (g), interstitium (i), tubules(t), and arterial vessels (v) were scored. Severity of acute rejection was statistically associated with unresponsiveness to anti-rejection treatment ( P<0.0001) and predicted an increased risk of graft failure ( P<0.05). Each quantitative criterion (g, i, t, and v) was also statistically associated with unresponsiveness to anti-rejection treatment. Mean serum creatinine levels were significantly higher in the groups graded Banff 97 type I-III after 1 and 2 years of follow-up. The Banff 97 classification correlated with reversibility of rejection episodes and long-term graft survival.
authors.affiliation: Department of Urology, Gunma University School of Medicine, Maebashi City, Gunma, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Tanaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kyo
authors.forename: Yukito
authors.initials: Y
authors.lastname: Kokado
authors.forename: Shiro
authors.initials: S
authors.lastname: Takahara
authors.forename: Motoaki
authors.initials: M
authors.lastname: Hatori
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Suzuki
authors.forename: Masaru
authors.initials: M
authors.lastname: Hasumi
authors.forename: Kiyohide
authors.initials: K
authors.lastname: Toki
authors.forename: Naotsugu
authors.initials: N
authors.lastname: Ichimaru
authors.forename: Koji
authors.initials: K
authors.lastname: Yazawa
authors.forename: Toru
authors.initials: T
authors.lastname: Hanafusa
authors.forename: Yukiomi
authors.initials: Y
authors.lastname: Namba
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Oka
authors.forename: Toshiki
authors.initials: T
authors.lastname: Moriyama
authors.forename: Enyu
authors.initials: E
authors.lastname: Imai
authors.forename: Akihiko
authors.initials: A
authors.lastname: Okuyama
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Yamanaka
mesh_terms: D001706:Biopsy; D006084:Graft Rejection / Q000453:epidemiology / Q000473:pathology; D006085:Graft Survival / Q000502:physiology; D006650:Histocompatibility Testing; D006801:Humans; D007564:Japan; D016030:Kidney Transplantation / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D016019:Survival Analysis; D014184:Transplantation, Homologous / Q000473:pathology*; D017211:Treatment Failure; D016896:Treatment Outcome