title: Cluster C personality disorder and recovery from major depression: 24-month prospective follow-up.
abstract: We investigated whether Cluster C personality disorder (CPD) is associated with recovery from depression. Changes in symptom scales in 30 patients with MD and CPD were compared with changes in 60 patients with MD alone over a 24-month follow-up period. Recovery of patients with MD and comorbid CPD was inferior to recovery of those with MD alone based on the Hamilton and Beck Depression Inventory (BDI) scales, and the SCL-90 total score. Only 18% of those with MD alone but 47% of those with CPD and MD met the criteria for major depression at the end of the 24-month follow-up. Multiple logistic regression analyses revealed an independent association between the lack of recovery (BDI score > 9 at 24 months) and the presence of CPD (OR 4.9, 95% CI 1.5-16.0). Moreover, the presence of CPD associated with the presence of major depression at 24 months (OR 4.2, 95% CI 1.4-12.2). The presence of CPD hinders the alleviation of depressive symptoms in major depression.
authors.affiliation: Department of Psychiatry, Kuopio University Hospital, Kuopio, Finland. heimo.viinamaki@kuh.fi
authors.forename: Heimo
authors.initials: H
authors.lastname: Viinamäki
authors.forename: Antti
authors.initials: A
authors.lastname: Tanskanen
authors.forename: Heli
authors.initials: H
authors.lastname: Koivumaa-Honkanen
authors.forename: Kaisa
authors.initials: K
authors.lastname: Haatainen
authors.forename: Kirsi
authors.initials: K
authors.lastname: Honkalampi
authors.forename: Risto
authors.initials: R
authors.lastname: Antikainen
authors.forename: Jukka
authors.initials: J
authors.lastname: Hintikka
mesh_terms: D000328:Adult; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010554:Personality Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D011446:Prospective Studies; D020127:Recovery of Function; D011795:Surveys and Questionnaires