Relationship between glutathione S-transferase P1 polymorphism and bronchial asthma and atopic dermatitis.
We determined the prevalence of GSTP1-Ile105 and GSTP1-Val105 alleles in patients with bronchial asthma and atopic dermatitis and healthy children of 2 groups (randomized and nonatopic control). The GSTP1-Ile105/Val105 genotype determines the resistance to atopic dermatitis (odds ratio=0.51; 95% confidence interval: 0.28-0.92; p=0.023). However, both homozygotes are at high risk of developing atopic dermatitis (near-significant differences).
Safronova
O G
OG
Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. drugsmet@.cyber.ma.nsc.ru
Vavilin
V A
VA
Lyapunova
A A
AA
Makarova
S I
SI
Lyakhovich
V V
VV
Kaznacheeva
L F
LF
Manankin
N A
NA
Batychko
O A
OA
Gavalov
S M
SM
D000483:Alleles; D001249:Asthma / Q000235:genetics*; D002648:Child; D003876:Dermatitis, Atopic / Q000235:genetics*; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D007532:Isoleucine / Q000737:chemistry; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012306:Risk; D012426:Russia; D014633:Valine / Q000737:chemistry; D015262:Xenobiotics / Q000494:pharmacology
D015262:Xenobiotics; D007532:Isoleucine; D005982:Glutathione Transferase; D014633:Valine