A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice.
Psoriasis is a skin disease with epidermal keratinocyte hyperproliferation and altered differentiation. To identify novel psoriasis-related genes, we investigated differentially expressed genes between normal and psoriatic skin. We identified a novel acyl CoA:diacylglycerol acyltransferase 2 (DGAT2) gene, which was decreased in human psoriatic skin. DGAT2 mRNA was expressed in sebaceous glands of normal human skin. DGAT2 protein was detected on endoplasmic reticulum. DGAT2 catalyzes the final step in the production of triglycerides and the accumulation of triglycerides in the tissues is considered to be related to insulin resistance. Therefore, we also investigated the expression of the DGAT2 gene in diabetic mice. DGAT2 mRNA was increased in the adipose, small intestine, and skeletal muscle in diabetic mice.
Wakimoto
Koji
K
Discovery Research Laboratory, Advanced Medical Research Department, Tanabe Seiyaku Co., Ltd, 3-16-89 Kashima, Yodogawa-ku, Osaka 532-8505, Japan. wakimoto@tanabe.co.jp
Chiba
Hiroaki
H
Michibata
Hideo
H
Seishima
Mariko
M
Kawasaki
Satoshi
S
Okubo
Kousaku
K
Mitsui
Hiroshi
H
Torii
Hideshi
H
Imai
Yuji
Y
D000217:Acyltransferases / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D015152:Blotting, Northern; D003920:Diabetes Mellitus / Q000378:metabolism*; D051048:Diacylglycerol O-Acyltransferase; D015536:Down-Regulation; D005786:Gene Expression Regulation; D006367:HeLa Cells; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D011565:Psoriasis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D012627:Sebaceous Glands / Q000473:pathology; D012867:Skin / Q000378:metabolism* / Q000473:pathology
D000217:Acyltransferases; C494885:DGAT2 protein, human; C494882:Dgat1 protein, mouse; D051048:Diacylglycerol O-Acyltransferase