[Isolation of Penicillium DIERCKX 1901--a producer of diketopiperazine alkaloids rokefortin and 3,12-dihydrokefortin--from permafrost].
Secondary metabolites of the three strains of Penicillium aurantiogriseum, isolated from permafrost sediments, were identified. It was found that these fungi synthesized diketopiperazine alkaloids roquefortine and 3,12-dihydroroquefortine. The strain VKM FW-766 synthesized alkaloids in in the course of certain growth-related processes. When the strain was grown on a mineral medium, time courses of roquefortine and 3,12-dihydroroquefortine concentrations were characterized by biphasic curves.
Kozlovskiĭ
A G
AG
Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, Pushchino, Moscow Oblast, 142290 Russia. Kozlovski@ibpm.serpukhov.su
Zhelifonova
V P
VP
Adanin
V M
VM
Antipova
T V
TV
Szerskaia
S M
SM
Ivanushkina
N E
NE
Grafe
U
U
D000470:Alkaloids / Q000096:biosynthesis*; D010407:Penicillium / Q000378:metabolism*
D000470:Alkaloids