Urinary excretion of endothelin-1 in children with absorptive idiopathic hypercalciuria.
Urinary excretion of endothelin-1 (ET-1) and plasma ET-1 were measured in 21 children with absorptive idiopathic hypercalciuria (AIH) and 22 controls. The absorptive type of idiopathic hypercalciuria was determined by a calcium loading test. Daily urinary excretion of ET-1 and urinary ET-1/creatinine ratio were significantly increased ( P=0.005 and P=0.007, respectively) in patients with AIH (9274+/-6444 pg/24 h and 14.04+/-9.52 pg/mg, respectively) compared with controls (4699+/-2120 pg/24 h and 7.36+/-4.71 pg/mg, respectively). Plasma ET-1 levels were significantly lower in patients with AIH (0.84+/-0.64 pg/ml) than in controls (1.54+/-0.54 pg/ml, P=0.0001). In conclusion, patients with AIH had increased urinary ET-1 excretion and decreased plasma ET-1 levels. This is most likely due to the decreased reabsorption of ET-1 in the renal tubule and increased renal production.
Nicolaidou
Polyxeni
P
First Pediatric Department, Athens University Medical School, "Aghia Sophia" Children's Hospital, Athens, Greece. anpapado@med.uoa.gr
Georgouli
Helen
H
Getsi
Vasiliki
V
Tsapra
Helen
H
Psychou
Fotini
F
Matsinos
Yiannis G
YG
Zeis
Petros M
PM
Gourgiotis
Dimitris
D
D002118:Calcium / Q000652:urine*; D016022:Case-Control Studies; D002648:Child; D003404:Creatinine / Q000652:urine; D019332:Endothelin-1 / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D009318:Natriuresis; D009994:Osmolar Concentration
D019332:Endothelin-1; D003404:Creatinine; D002118:Calcium