title: Anatomy and physiology of chronic pain.
abstract: Although much has been accomplished in the past several decades, treatment of chronic pain remains imperfect. This article presents the anatomy and physiology of the pain system along with the neurobiologic changes that occur in the establishment and maintenance of chronic pain states.
authors.affiliation: Section of Functional and Stereotactic Neurosurgery, S31, Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. rosenoj@ccf.org
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Rosenow
authors.forename: Jaimie M
authors.initials: JM
authors.lastname: Henderson
mesh_terms: D001921:Brain / Q000503:physiopathology; D002908:Chronic Disease; D004525:Efferent Pathways / Q000503:physiopathology; D006801:Humans; D009420:Nervous System / Q000503:physiopathology; D009473:Neuronal Plasticity; D009619:Nociceptors / Q000503:physiopathology; D010146:Pain / Q000503:physiopathology*; D012677:Sensation; D013116:Spinal Cord / Q000503:physiopathology