Identification of an anti-inflammatory principle from the stem bark of Millettia versicolor.
The dichloromethane-soluble fraction of the methanol extract of the stem bark of Millettia versicolor Welw. (Leguminosae) has been shown to possess anti-inflammatory activity. The chromatographic fractionation and subsequent analysis of the spectroscopic data of this extract led to the isolation and identification of 2-acetyl-7-methoxynaphtho[2,3- b]furan-4,9-quinone (1) along with two known quinones. Pharmacological data demonstrate that compound 1 has relevant anti-inflammatory properties whereas the other two isolated compounds do not.
Fotsing
Maurice Tagatsing
MT
Department of Organic Chemistry, University of Yaounde 1, Yaounde, Cameroon.
Yankep
Emmanuel
E
Njamen
Dieudonné
D
Fomum
Z Tanee
ZT
Nyasse
Barthelemy
B
Bodo
B
B
Recio
M Carmen
MC
Giner
Rosa M
RM
Ríos
José-Luis
JL
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D033641:Millettia; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D002351:Carrageenan