The novel gluconeogenesis inhibitors FR225659 and related compounds that originate from Helicomyces sp. No. 19353. II. Biological profiles.
The novel gluconeogenesis inhibitor FR225659 and four related compounds were isolated from the cultured broth of a fungal strain No. 19353. These compounds inhibited the glucagon-stimulated gluconeogenesis of rat primary hepatocytes and had hypoglycemic effects in two different in vivo models.
Ohtsu
Yoshihiro
Y
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. yoshihiro_ohtsu@po.fujisawa.co.jp
Sasamura
Hiromi
H
Shibata
Toshihiro
T
Nakajima
Hidenori
H
Hino
Motohiro
M
Fujii
Takashi
T
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D005943:Gluconeogenesis / Q000187:drug effects*; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D006943:Hyperglycemia / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D051381:Rats
D007004:Hypoglycemic Agents