Antineoplastic effects of partially HLA-matched irradiated blood mononuclear cells in patients with renal cell carcinoma.
OBJECTIVE
Vaccines, cytokines, and other biologic-based therapies are being developed as antineoplastic agents. Many of these agents are designed to induce an autologous immune response directed against the malignancy. In contrast, hematopoietic stem-cell transplantation is being developed as a form of allogeneic immunotherapy. This study tests the tolerance and antineoplastic activity of sequential infusions of partially HLA-matched allogeneic blood mononuclear cells (obtained from relatives) when administered outside of the context of a hematopoietic stem-cell transplantation. The cells are irradiated to prevent graft-versus-host disease.


METHODS
Fifteen patients with relapsed or refractory malignancies for which no standard therapy was available were enrolled onto a clinical trial designed to assess the tolerability and antineoplastic effects of irradiated partially HLA-matched blood mononuclear cells obtained from relatives.


RESULTS
There was disease regression in three patients with metastatic renal cell carcinoma during treatment. There was disease progression in six patients with metastatic renal cell carcinoma and two patients with metastatic melanoma during treatment. There was no change in disease state in several other patients.


CONCLUSIONS
Irradiated allogeneic blood mononuclear cells administered outside the context of hematopoietic stem-cell transplantation may induce disease responses in patients with relapsed or refractory malignancies. Transfusion of irradiated allogeneic blood mononuclear cells should be developed further as a novel therapeutic antineoplastic approach.
Strair
Roger K
RK
Division of Medical Oncology and Surgical Oncology, Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA. strairrk@umdnj.edu
Schaar
Dale
D
Medina
Daniel
D
Todd
Mary B
MB
Aisner
Joseph
J
DiPaola
Robert S
RS
Manago
Jacqueline
J
Knox
Beth
B
Jenkinson
Amanda
A
Senzon
Rachelle
R
Baker
Christina
C
Liesel
Dudek
D
Ciardella
Marie
M
Kuriyan
Mercy
M
Rubin
Arnold
A
Lattime
Edmund C
EC
D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000628:therapy*; D017690:Cell Transplantation; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007680:Kidney Neoplasms / Q000628:therapy*; D007694:Killer Cells, Natural / Q000276:immunology* / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects
D006680:HLA Antigens