Design and synthesis of C3-symmetric Lewis(x) antigen.
[structure: see text] C(3)-Symmetric glycoconjugates carrying three equivalent Lewis(X) antigens or beta-lactosides were synthesized from p-nitrophenyl glycosides and trimesic acid via regio- and stereocontrolled glycosylation reactions. An (1)H NMR study has shown that the C(3)-symmetric glycoconjugates soluble in water provide useful probes to investigate the Ca(2+)-dependent Lewis(X)-Lewis(X) association.
Nishida
Yoshihiro
Y
Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa-ku, Nagoya 464-8603, Japan. nishida@mol.nagoya-u.ac.jp
Tsurumi
Tomoaki
T
Sasaki
Kenji
K
Watanabe
Kenta
K
Dohi
Hirofumi
H
Kobayashi
Kazukiyo
K
D002118:Calcium / Q000737:chemistry; D002240:Carbohydrate Sequence; D006031:Glycosylation; D006801:Humans; D016256:Lewis X Antigen / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data
D016256:Lewis X Antigen; D002118:Calcium