title: AMPA glutamate receptors and neuropathic pain.
abstract: Glutamate receptors are implicated in many actions in the central nervous system, as an excitatory amino acid, and one of the more relevant is its role in excitotoxicity. Apart from this, it also has a role as pro-nociceptive agent, so that antagonizing its actions could be of interest for developing new analgesic agents. Furthermore, between the analgesics agents, it is of outstanding interest the fact that there is no specific therapy against the neuropathic pain, and glutamate receptor subunits have elicited as new potential targets for this disturbance.
authors.affiliation: Neuropharma S. A. Avda. de la Industria 52, 28760 Tres Cantos, Spain.
authors.forename: Susana
authors.initials: S
authors.lastname: Morales-Alcelay
authors.forename: Laura
authors.initials: L
authors.lastname: Rubio
authors.forename: Ana
authors.initials: A
authors.lastname: Martinez
mesh_terms: D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D018698:Glutamic Acid / Q000502:physiology; D006801:Humans; D010146:Pain / Q000188:drug therapy* / Q000503:physiopathology; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy* / Q000503:physiopathology; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors / Q000187:drug effects* / Q000502:physiology
chemical_list: D000700:Analgesics; D018691:Excitatory Amino Acid Antagonists; D018091:Receptors, AMPA; D018698:Glutamic Acid