Automated preparation of 188Re-labeled radiopharmaceuticals for endovascular radiation therapy.
We have developed an automated system for the preparation of highly concentrated 188Re-perrhenate, diethylenetriamine pentaacetic acid (DTPA) and mercaptoacetyltriglycine (MAG3). The three procedural steps include concentration of 188Re-perrhanerate, chelation and purification and sterilization. The steps are operated by a small micro-controller. The eluted 188Re-perrhenate of 15 GBq/18 ml from 37 GBq 188W/188Re-generator was concentrated to 1.2 ml in 10 +/- 0.5 min with a recovery yield of 95 +/- 1.5%. We obtained the highest radiochemical yield of 95.4 +/- 2.8% and 98.5 +/- 1.2% for 188Re-DTPA and MAG3 at the oil bath temperatures of 95-97 degrees C and 93-97 degrees C, respectively.
Oh
Seung Jun
SJ
Departments of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-2dong, Songpa-gu, Seoul 138-736, South Korea. sjoh@www.amc.seoul.kr
Moon
Dae Hyuk
DH
Lee
Won Woo
WW
Park
Seong-Wook
SW
Hong
Myeong-Ki
MK
Park
Seung-Jung
SJ
Shin
Dong-Ik
DI
Lee
Hee Kyung
HK
D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods; D003199:Computer Systems; D003205:Computing Methodologies; D023903:Coronary Restenosis / Q000517:prevention & control / Q000532:radiotherapy; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification; D006801:Humans; D007553:Isotope Labeling / Q000295:instrumentation* / Q000379:methods; D004369:Pentetic Acid / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification; D011868:Radioisotopes / Q000737:chemistry* / Q000302:isolation & purification; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D012211:Rhenium / Q000737:chemistry* / Q000302:isolation & purification; D012371:Robotics / Q000295:instrumentation* / Q000379:methods; D018511:Systems Integration; D014652:Vascular Diseases / Q000517:prevention & control / Q000532:radiotherapy
D011868:Radioisotopes; D019275:Radiopharmaceuticals; C015428:perrhenate; C096273:N-(mercaptoacetyl)glycine; D012211:Rhenium; D004369:Pentetic Acid; D005998:Glycine