MK-801 attenuates cocaine induction of c-fos and preprodynorphin mRNA levels in Fischer rats.
This study shows that single (15 mg/kg) or binge (3x15 mg/kg) cocaine administration increases c-fos mRNA levels, but only binge cocaine administration increases preprodynorphin mRNA levels in the caudate/putamen of Fischer rats. This increase in both c-fos and preprodynorphin mRNA levels is attenuated by the noncompetitive NMDA antagonist MK-801 (0.25 mg/kg), suggesting a preferential role for NMDA receptor co-activation in cellular events leading to cocaine-induced behaviors.
Jenab
Shirzad
S
Department of Psychology, Hunter College of City University of New York, 695 Park Ave, New York, NY 10021, USA. sjenab@hunter.cuny.edu
Festa
Eugene D
ED
Russo
Scott J
SJ
Wu
Hui Bing K
HB
Inturrisi
Charles E
CE
Quinones-Jenab
Vanya
V
D000779:Anesthetics, Local / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D003042:Cocaine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004334:Drug Administration Schedule / Q000662:veterinary; D004347:Drug Interactions; D004399:Dynorphins / Q000096:biosynthesis* / Q000235:genetics; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects*; D008297:Male; D011498:Protein Precursors / Q000096:biosynthesis* / Q000235:genetics; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344
D000779:Anesthetics, Local; D018691:Excitatory Amino Acid Antagonists; D011498:Protein Precursors; D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; C036448:pre-prodynorphin; D016291:Dizocilpine Maleate; D004399:Dynorphins; D003042:Cocaine