Anti-tumor activities of decursinol angelate and decursin from Angelica gigas.
The in vivo anti-tumor activities of decursinol angelate (1) and decursin (2) isolated from the roots of Angelica gigas were investigated. These two compounds, when administered consecutively for 9 days at 50 and 100 mg/kg i.p. in mice, caused a significant increase in the life span and a significant decrease in the tumor weight and volume of mice inoculated with Sarcoma-180 tumor cells. These results suggest that decursinol angelate (1) and decursin (2) from A. gigas have anti-tumor activities.
Lee
Sanghyun
S
Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul 110-460, Korea.
Lee
Yeon Sil
YS
Jung
Sang Hoon
SH
Shin
Kuk Hyun
KH
Kim
Bak-Kwang
BK
Kang
Sam Sik
SS
D029969:Angelica / Q000737:chemistry*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002087:Butyrates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000637:transplantation; D005472:Fluorouracil / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D007723:Korea; D008297:Male; D008518:Medicine, East Asian Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D009368:Neoplasm Transplantation / Q000473:pathology; D009369:Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry; D012510:Sarcoma 180 / Q000188:drug therapy / Q000473:pathology; D015996:Survival Rate
D000972:Antineoplastic Agents, Phytogenic; D001578:Benzopyrans; D002087:Butyrates; D010936:Plant Extracts; C101278:decursin; D005472:Fluorouracil