title: The hemodynamic effects of acute myocardial ischemia and reperfusion in Clawn miniature pigs.
abstract: Acute myocardial ischemia was induced by occluding the LAD in Clawn miniature pigs. Eight pigs (group 1) were subjected to 6 h ischemia and nine pigs (group 2) were subjected to 20 min ischemia, followed by reperfusion for 340 min. Three animals of the group 1 died due to ventricular fibrillation after occlusion and in group 2, four animals died due to the arrhythmia after reperfusion. Though the ischemic area of group 2 (15.6% of the ventricle) was narrower than that of group 1 (21.7%), the survival rate was lower. We supposed that ischemia-reperfusion injuries were strongly connected with the hemodynamics of group 2. Clawn miniature pigs are useful experimental animals for myocardial ischemic researches.
authors.affiliation: Division of Laboratory Animal Science, Research Center for Life Science Resources, Kagoshima University, Sakuragaoka 8-35-1, Kagoshima 890-8520, Japan.
authors.forename: Ryozo
authors.initials: R
authors.lastname: Kamimura
authors.forename: Naoki
authors.initials: N
authors.lastname: Miura
authors.forename: Syusaku
authors.initials: S
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D006439:Hemodynamics / Q000502:physiology*; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology*; D013556:Swine, Miniature / Q000502:physiology*