A new technetium-99m labeled isonitrile complex 99mTc-TMCHI as a potential blood pool imaging agent.
A new isonitrile ligand 3,3,5-trimethyl cyclohexylisonitrile (TMCHI) and its copper salt [Cu(TMCHI)4BF4] were synthesized and characterized by IR and elemental analysis. 99mTc-TMCHI is prepared by direct labeling method with high RCP. In vitro protein binding in albumin, blood retention and biodistribution of 99mTc-TMCHI in mice indicated that it is mainly accumulated and maintained in blood with a high protein binding rate and low washout rate. The target/non-target ratios in mice are excellent and suggest its use as a cardiac blood pool agent.
Zhang
X Zh
XZh
Department of Chemistry, Beijing Normal University, Beijing 100875, People's Republic of China.
Wang
X B
XB
Zhou
J M
JM
D000818:Animals; D015637:Gated Blood-Pool Imaging / Q000295:instrumentation / Q000379:methods*; D006321:Heart / Q000000981:diagnostic imaging*; D007553:Isotope Labeling / Q000379:methods*; D008657:Metabolic Clearance Rate; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D009570:Nitriles / Q000097:blood / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics*; D009928:Organ Specificity; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics*; D019275:Radiopharmaceuticals / Q000097:blood / Q000138:chemical synthesis / Q000493:pharmacokinetics; D014018:Tissue Distribution
C480799:99m technetium-3,3,5-trimethyl cyclohexylisonitrile; D009570:Nitriles; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals