Intraocular lens with reversibly adjustable optical power: pilot study of concept and safety.
OBJECTIVE
To evaluate whether it is technically feasible and safe to implant and adjust an intraocular lens (IOL) with reversibly adjustable refractive power designed to correct residual postoperative refractive error.


METHODS
Animal study facility, Klinikum Mannheim, University of Heidelberg, Heidelberg, Germany.


METHODS
An Acri.Tec AR-1 posterior chamber IOL (PC IOL) was implanted in pig cadaver eyes and in rabbit eyes after the crystalline lens was removed by phacoemulsification. The IOL was manipulated to change the refractive power. The outcome measures were the stability of the IOL during implantation, IOL positioning and rotation, the ability to move the adjustment device after the IOL had been implanted for several weeks, clinical signs of inflammation, and changes in the histopathologic appearance of the eye.


RESULTS
Implantation and adjustment of refractive power were possible. The eyes healed normally. There was no difference between eyes with the AR-1 PC IOL and eyes with a control IOL in inflammatory reaction, corneal transparency, or histopathologic appearance.


CONCLUSIONS
The AR-1 PC IOL was easy to implant and well tolerated in rabbit eyes. Surgical adjustment of the adjusting element was performed with little effort several weeks after implantation of the IOL.
Jahn
Claus E
CE
Augenpraxisklinik Dr. Jahn, Kempten, Germany. praxisdrjahn@t-online.de
Jahn
Marianne A
MA
Kreiner
Christine F
CF
Serester
Alexander
A
Fromberg
Ingeborg
I
Jacobi
Susan
S
Deutschmann
Siegfried
S
Schäffer
Ekkehard H
EH
Kamppeter
Bernd A
BA
D000818:Animals; D004867:Equipment Design; D066298:In Vitro Techniques; D007498:Iris / Q000473:pathology; D019654:Lens Implantation, Intraocular / Q000295:instrumentation; D007910:Lenses, Intraocular / Q000009:adverse effects; D055095:Optics and Photonics; D010865:Pilot Projects; D011817:Rabbits; D012449:Safety; D013552:Swine