[Specific immunotherapy for respiratory allergies. A modern treatment].
AN EFFICIENT AETIOLOGICAL TREATMENT: Specific immunotherapy or allergen vaccination currently constitutes the only aetiological treatment for allergic respiratory diseases and is more effective in children than in adults. Since its introduction in 1911, it has been much disparaged in spite of its effectiveness demonstrated in double blind placebo controlled studies, for the treatment of both allergic rhinoconjunctivitis and stable and controlled asthma.


RESULTS
Its mechanism of action varies depending on the type of allergen (venoms or pneumallergenes) and its administration route (subcutaneous or local) and recent studies indicate that the prevalent mechanism proceeds from a modification of the T cell response by an immunological deviation (stimulation of the Th0/Th1 lymphocytes) or T lymphocyte anergy (reduction in Th0/Th2) or both at same time. The IL-10, immunosuppressive cytokine secreted by the third population of T-Tr1 lymphocytes, would have an important role.


CONCLUSIONS
The indications for specific immunotherapy have been specified in international consensuses, and its practical administration must respect preconditions and a certain number of rules. Improvement in quality of allergenic extracts by standardization, better knowledge of its mechanism of action and the availability of local administration routes reinforce its place in the global therapeutic strategy for the management of respiratory allergies. A greater use of the sublingual route, together with biological and clinical research will allow the widening of its indications.
Ndiaye
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M
Service des maladies respiratoires, exploration des allergies, Inserm U454-IFR3, Hôpital Arnaud de Villeneuve, CHU de Montpellier.
Dhivert-Donnadieu
H
H
Demoly
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P
D000485:Allergens / Q000008:administration & dosage* / Q000276:immunology; D003888:Desensitization, Immunologic / Q000379:methods*; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D011785:Quality Assurance, Health Care; D012130:Respiratory Hypersensitivity / Q000188:drug therapy* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D016896:Treatment Outcome
D000485:Allergens; D000939:Epitopes; D016753:Interleukin-10