Receptor "cross talk" in innate immunity.
Toll-like receptors (TLRs) recognize microbial molecular signatures and can initiate innate immune responses against invading pathogens. A new study (see the related article beginning on page 1234) reports how TLR2 expression by endothelia is locally upregulated by the action of activated polymorphonuclear neutrophils via an unprecedented mechanism involving cell-cell interaction and NAD(P)H oxidase. The report reveals yet another way in which the primordial innate immune system is remarkably complex.
Latz
Eicke
E
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Golenbock
Douglas T
DT
D000818:Animals; D008562:Membrane Glycoproteins / Q000502:physiology*; D051379:Mice; D019255:NADPH Oxidases / Q000502:physiology*; D009504:Neutrophils / Q000201:enzymology* / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology*; D051195:Toll-Like Receptor 2; D051193:Toll-Like Receptors
D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051195:Toll-Like Receptor 2; D051193:Toll-Like Receptors; D019255:NADPH Oxidases