Effect of HIV-1 antiretroviral drugs on cytoadherence and phagocytic clearance of Plasmodium falciparum-parasitised erythrocytes.
In response to the HIV/AIDS pandemic, antiretroviral treatment is currently being implemented in sub-Saharan Africa, where malaria and HIV-1 co-infections are highly prevalent. The effectiveness and tolerability of antiretrovirals in patients with malaria and HIV-1 co-infection have not been investigated. Antiretrovirals decrease CD36 surface concentrations in vivo, which might impair receptor function and affect parasite-host interactions. Thus, we investigated the effects of these drugs on CD36-mediated cytoadherence and non-opsonic phagocytosis of Plasmodium falciparum parasitised erythrocytes in vitro. The protease-inhibitor class of antiretrovirals particularly impairs CD36-mediated cytoadherence and non-opsonic phagocytosis of parasitised erythrocytes by human macrophages. Such treatment might therefore contribute to altered malaria disease outcomes in co-infected patients.
Nathoo
Salima
S
Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University Health Network-Toronto General Hospital and the University of Toronto, ON, Canada.
Serghides
Lena
L
Kain
Kevin C
KC
D017954:Africa South of the Sahara / Q000453:epidemiology; D000818:Animals; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D002448:Cell Adhesion / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D015897:Comorbidity; D004912:Erythrocytes / Q000469:parasitology; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology; D017320:HIV Protease Inhibitors / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D015497:HIV-1; D006790:Host-Parasite Interactions / Q000187:drug effects / Q000276:immunology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis / Q000276:immunology; D016778:Malaria, Falciparum / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology / Q000502:physiology; D010963:Plasmodium falciparum / Q000469:parasitology; D017463:Receptors, Complement 3b / Q000032:analysis / Q000276:immunology
D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D017463:Receptors, Complement 3b; D018799:Intercellular Adhesion Molecule-1