title: Non-inhibition of acetylcholinesterase by cycloSal nucleotides.
abstract: An acetylcholinesterase (AChE) assay based on the Rappaport method was established to investigate the behaviour of several cycloSal nucleotides against AChE from electrophorus electricus and human sources (purified enzymes). AChE is a physiologically essential enzyme as it catalyzes the hydrolysis of the neurotransmitter acetylcholine. No inhibition was observed in any of the cases.
authors.affiliation: Institute of Organic Chemistry, University of Hamburg, Hamburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Ducho
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
authors.forename: C
authors.initials: C
authors.lastname: Meier
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D004593:Electrophorus; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009711:Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; D009711:Nucleotides; D000110:Acetylcholinesterase