End-stage kidney at the onset of nephrotic syndrome in a 4-year-old girl.
A previously healthy Japanese girl aged 4 years suddenly developed idiopathic nephrotic syndrome (INS) associated with acute renal failure (ARF). Despite prompt initiation of hemodialysis and prednisolone treatment, her ARF did not recover. A percutaneous renal biopsy performed within a month from the onset of INS revealed lesions of end-stage kidney, which is unusual for the acute stage of INS. Although the etiology of her ARF remains speculative, an acute exacerbation of an underlying chronic disease, such as non-nephrotic focal segmental glomerulosclerosis might be the cause.
Nakahata
Tohru
T
Department of Pediatrics, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan.
Tanaka
Hiroshi
H
Tsuruga
Kazushi
K
Shimada
Jun
J
Tsugawa
Koji
K
Suzuki
Koichi
K
Onodera
Norio
N
Ito
Etsuro
E
D058186:Acute Kidney Injury / Q000150:complications* / Q000175:diagnosis; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D011239:Prednisolone