Gonadotoxic effects of antitumor preparations.
Here we review the results of experimental and clinical observations concerning the gonadotoxic effect of antitumor chemotherapy. Previous experiments showed that antiblastic preparations with various mechanisms of cytostatic action produce damage to the sex glands that differs in the severity, stage of manifestation, and period of reparative regeneration. These differences are related to different sensitivity of epitheliocytes in the testes and structural and functional elements in the ovaries. Morphological changes in the gonads are accompanied by dysfunction of the reproductive system. We compared damages to the reproductive system and its individual components produced by various antitumor preparations. The offspring was examined after cytostatic treatment of one of the parent animals.
Gol'dberg
E D
ED
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Borovskaya
T G
TG
D000818:Animals; D000831:Animals, Newborn; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000633:toxicity*; D005260:Female; D006801:Humans; D008297:Male; D018811:Maternal Exposure; D010053:Ovary / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D018812:Paternal Exposure; D013737:Testis / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology
D000970:Antineoplastic Agents