Design of synthetic peptides for diagnostics.
Due to the advantageous properties of synthetic molecules compared to biological ones biological molecules in diagnostic tests are replaced increasingly by synthetic ones, usually synthetic peptides or related molecules. The replacement of biological antigens by synthetic peptides is most advanced at present, as well as the use of site-specific antibodies induced with synthetic peptides. Moreover recent results indicate that synthetic molecules may also replace antibodies. Ultimately this will lead to diagnostic assays built of synthetic molecules only.
Meloen
R H
RH
Pepscan Systems, P.O. Box 2098, 8203 AB Lelystad, The Netherlands. r.h.meloen@pepscan.nl
Puijk
W C
WC
Langeveld
J P M
JP
Langedijk
J P M
JP
Timmerman
P
P
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D015195:Drug Design; D018604:Epitope Mapping / Q000379:methods; D018985:Epitopes, B-Lymphocyte / Q000737:chemistry; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007150:Immunohistochemistry; D007159:Immunologic Tests / Q000379:methods; D018716:Molecular Mimicry; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D040081:Protein Array Analysis / Q000379:methods; D017434:Protein Structure, Tertiary; D020539:Sequence Analysis, Protein
D000911:Antibodies, Monoclonal; D018985:Epitopes, B-Lymphocyte; D007106:Immune Sera; D019151:Peptide Library; D010455:Peptides