A new approach for syntheses of 2',3'-dideoxy-2',3'-dehydronucleosides using 2,2-difluoro-1,3-dimethylimidazolidine (DFI) as a dehydrating reagent.
We found that 2,2-difluoro-1,3-dimethylimidazolidine (DFI) is useful for not only fluorination but also dehydrating reactions. This dehydrating ability of DFI was applied to the syntheses of dihydrofurans (2) that are possible starting materials for various anticancer or antiviral drugs.
Umetani
Hideki
H
Catalysis Science Laboratory, Mitsui Chemicals Inc., Sodegaura-shi, Chiba, Japan. hideki.umetani@mitsui-chem.co.jp
Sonoda
Hiroshi
H
Komatsu
Hironori
H
D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives*; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D015224:Dideoxynucleosides / Q000138:chemical synthesis*; D015195:Drug Design; D007093:Imidazoles; D007202:Indicators and Reagents
D000970:Antineoplastic Agents; D015224:Dideoxynucleosides; D007093:Imidazoles; D007202:Indicators and Reagents; D000620:Aminoimidazole Carboxamide; C031340:imidazolecarboxamide