title: Severe Graves' ophthalmopathy after retrobulbar anesthesia for cataract extraction in a patient with mild stable thyroid eye disease.
abstract: It has been hypothesized that the distinct anatomic localization of the Graves' triad may be partially explained by pressure and trauma. While there are reports of local trauma clearly contributing to the pathogenesis of pretibial myxedema, direct evidence for a similar mechanism in Graves' ophthalmopathy (GO) has been lacking. We describe a 65-year-old male patient with stable mild Graves' ophthalmopathy of 24 years' duration in whom a retrobulbar block was administered prior to cataract removal. Three weeks after the procedure, he complained of rapidly progressive bilateral diplopia. In 6 months, there was moderate exophthalmos, exposure keratitis, almost complete ophthalmoplegia, and decreasing visual acuity requiring surgical decompression. Postdecompression, inflammatory signs and vision improved but there was complete ophthalmoplegia. The eye signs remained unchanged for the next 4 months but there was exacerbation of the disease within a week of receiving radioiodine despite concomitant steroid administration. Orbital irradiation was finally administered with rapid improvement in extraocular eye muscle function. We hypothesize that local inflammatory and immune responses stimulated by trauma and/or pressure in the retrobulbar compartment, triggered the development of severe ophthalmopathy in this patient. Thyroid-stimulating immunoglobulin (TSI) levels remained markedly elevated despite the clinical improvement suggesting that the beneficial effects of radiotherapy in this case were not mediated by suppressing TSI production.
authors.affiliation: Department of Endocrinology, Singapore General Hospital, Singapore.
authors.forename: Daniel Chun-Hang
authors.initials: DC
authors.lastname: Wai
authors.forename: Su-Chin
authors.initials: SC
authors.lastname: Ho
authors.forename: Lay-Leng
authors.initials: LL
authors.lastname: Seah
authors.forename: Kee-Siew
authors.initials: KS
authors.lastname: Fong
authors.forename: Daphne Hsu-Chin
authors.initials: DH
authors.lastname: Khoo
mesh_terms: D000368:Aged; D002387:Cataract Extraction / Q000009:adverse effects*; D005128:Eye Diseases / Q000000981:diagnostic imaging / Q000601:surgery*; D006111:Graves Disease / Q000209:etiology*; D006801:Humans; D008297:Male; D013959:Thyroid Diseases / Q000601:surgery*; D014057:Tomography, X-Ray Computed; D014792:Visual Acuity