title: Unprecedented intermolecular transamidation reaction of N-carbamoylmethyl-N'-tosylguanidines.
abstract: [reaction: see text] N-Carbamoylmethyl-N'-tosyl guanidine 2 reacts easily with primary alkylamines to afford substituted carboxamides 3. The reaction proceeds via a five-membered-ring intermediate 5, which could be isolated, and features a rare example of an intermolecular transamidation reaction under mild conditions.
authors.affiliation: Departamento de Química Orgánica, Universidad de Valencia, Avda. Vicent Andres Estelles s/n, 46100 Burjassot, Valencia, Spain.
authors.forename: Jamal
authors.initials: J
authors.lastname: Lasri
authors.forename: M Eugenia
authors.initials: ME
authors.lastname: González-Rosende
authors.forename: José
authors.initials: J
authors.lastname: Sepúlveda-Arques