title: Reducing integrins improves the quality of fly life.
abstract: Integrins are cell surface receptors that mediate adhesion to the extracellular matrix. In this Perspective, we focus on the recent finding that a decrease in the levels of integrins yields fruit flies that retain youthful mobility as they age and display an increased mean life span. We discuss how the reduction of integrin activity might lead to the observed changes.
authors.affiliation: Wellcome Trust/Cancer Research UK Institute and Department of Anatomy, University of Cambridge, Cambridge CB2 1QR, UK. cnt20@mole.bio.cam.ac.uk
authors.forename: Catherine N
authors.initials: CN
authors.lastname: Torgler
authors.forename: Nicholas H
authors.initials: NH
authors.lastname: Brown
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development* / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000378:metabolism* / Q000502:physiology*; D008136:Longevity / Q000235:genetics / Q000502:physiology*; D011788:Quality of Life
chemical_list: D016023:Integrins