Pergolide mesylate form II.
A new polymorph of pergolide mesylate or 8beta-[(methylsulfanyl)methyl]-6-propylergoline methanesulfonate, C(19)H(27)N(2)S(+).CH(3)SO(3)(-), is reported. Pergolide mesylate form II crystallizes in the trigonal system, which is unique for ergot derivatives. Although the hydrogen-bond system in form II differs completely from that in form I, the conformation of the pergolide moiety in various related structures is very similar.
Jegorov
Alexandr
A
IVAX Pharmaceuticals sro, Research Unit, Branisovská 31, 370 05 Ceské Budejovice, Czech Republic. alexandr_jegorov@ivax-cz.com
Horák
Zdenek
Z
Cejka
Jan
J
Kratochvíl
Bohumil
B
Císarová
Ivana
I
D000978:Antiparkinson Agents / Q000737:chemistry; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D010479:Pergolide / Q000737:chemistry*
D000978:Antiparkinson Agents; D010479:Pergolide