Short term therapy for uncomplicated urinary tract infection today. Clinical outcome upholds the theories.
The clinical and bacteriological activity of fosfomycin trometamol (FT) has been compared with several other antibiotics in the treatment of uncomplicated urinary tract infections. A single dose of FT had activity comparable with a 5-day course of trimethoprim in a trial where the causative organism and its sensitivity were unknown. In another trial FT showed better long term eradication compared with a 5-day course of cephalexin and other studies suggested a single dose of FT was comparable with a 7-day course of nitrofurantoin or norfloxacin. There were few important side effects with fosfomycin therapy and it was considered a safe and effective first line treatment in uncomplicated urinary tract infection.
Lobel
B
B
Department of Urology, Hopital Pontchaillou, Rue Henri le Guilloux, F-35033, Rennes, France. bernard.lobel@chu-rennes.fr
D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy; D002506:Cephalexin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005260:Female; D005578:Fosfomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008137:Longitudinal Studies; D015201:Meta-Analysis as Topic; D009582:Nitrofurantoin / Q000008:administration & dosage / Q000627:therapeutic use; D009643:Norfloxacin / Q000627:therapeutic use; D016896:Treatment Outcome; D014295:Trimethoprim / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D009582:Nitrofurantoin; D014295:Trimethoprim; D009643:Norfloxacin; D002506:Cephalexin