Synthesis of retro acyl carrier protein (74-65) fragment on a new glycerol based polystyrene support.
Retro-ACP (74-65) fragment was synthesized on a novel 4% tri-(propylene glycol) glycerolate diacrylate cross-linked polystyrene (PS-TRPGGDA) support. The peptide is grown from the functional site present in the cross-linker, which makes it unique and cost-effective among other styrene based polymer supports. A comparative study with Merrifield resin indicates high yield and purity of the peptide synthesized on the novel support.
Sasikumar
P G
PG
School of Chemical Sciences, Mahatma Gandhi University, Kottayam 686560, India.
Kumar
K S
KS
Pillai
V N Rajasekharan
VN
D000179:Acrylates / Q000737:chemistry; D000213:Acyl Carrier Protein / Q000138:chemical synthesis*; D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D003432:Cross-Linking Reagents / Q000737:chemistry; D005990:Glycerol / Q000737:chemistry; D010446:Peptide Fragments / Q000138:chemical synthesis*; D011137:Polystyrenes / Q000138:chemical synthesis*; D012997:Solvents
D000179:Acrylates; D000213:Acyl Carrier Protein; D003432:Cross-Linking Reagents; C095039:Merrifield resin; D010446:Peptide Fragments; D011137:Polystyrenes; D012997:Solvents; C078985:acyl carrier protein (65-74); D005990:Glycerol