The novel gluconeogenesis inhibitors FR225659 and related compounds that originate from Helicomyces sp. No. 19353. I. Taxonomy, fermentation, isolation and physico-chemical properties.
FR225659 and four related compounds are novel gluconeogenesis inhibitors that consist of a novel acyl-group and three abnormal amino acids. They were isolated from the culture broth of Helicomyces sp. No. 19353 and can be purified by absorptive resin and reverse-phase column chromatography. They are potent inhibitors of gluconeogenesis in primary cultured rat hepatocytes and thus may be useful as anti-diabetic agents.
Ohtsu
Yoshihiro
Y
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba, Ibaraki 300-2698, Japan. yoshihiro_ohtsu@po.fujisawa.co.jp
Sasamura
Hiromi
H
Tsurumi
Yasuhisa
Y
Yoshimura
Seiji
S
Takase
Shigehiro
S
Hashimoto
Michizane
M
Shibata
Toshihiro
T
Hino
Motohiro
M
Fujii
Takashi
T
D000818:Animals; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D005658:Fungi; D005943:Gluconeogenesis / Q000187:drug effects*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013329:Structure-Activity Relationship
D007004:Hypoglycemic Agents