title: Synthesis and studies of modified oligonucleotides-directed triple helix formation at the purine-pyrimidine interrupted site.
abstract: Triple helix formation is still restricted to oligopurine-oligopyrimidine double stranded DNA target. Herein we focus on our progress achieved in nucleobase and oligonucleotide modifications area to address the chemical challenge to circumvent the recognition of a purine-pyrimidine base pair interruption in an oligopyrimidine-oligopurine DNA sequence.
authors.affiliation: Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, Universitè des Sciences, Rabat, Morocco.
authors.forename: Mohamed
authors.initials: M
authors.lastname: Jazouli
authors.forename: Dominique
authors.initials: D
authors.lastname: Guianvarc'h
authors.forename: Khalid
authors.initials: K
authors.lastname: Bougrin
authors.forename: Mohamed
authors.initials: M
authors.lastname: Soufiaoui
authors.forename: Pierre
authors.initials: P
authors.lastname: Vierling
authors.forename: Rachid
authors.initials: R
authors.lastname: Benhida
mesh_terms: D020029:Base Pairing; D001483:Base Sequence; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D011687:Purines; D011743:Pyrimidines; D013329:Structure-Activity Relationship; D013816:Thermodynamics
chemical_list: D009838:Oligodeoxyribonucleotides; D011687:Purines; D011743:Pyrimidines