A new model for the human alimentary tract: the work of a Committee 2 task group.
The absorbed doses received from ingested radionuclides are currently calculated using the method outlined in ICRP Publication 30. It has been recognised by the ICRP that some of the assumptions used to calculate absorbed doses should be reviewed. A new physiologically based model has been developed, applicable to intakes of radionuclides in food and liquids by children and adults. All parts of the alimentary tract are included, additional sites for absorption and retention are considered and the morphometric and transit parameter values are reviewed in coordination with the ICRP Reference Man revision. Features of the new model are explained and preliminary dose estimates are presented.
Métivier
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Institut de Radioprotection et de Sûreté Nucléaire, BP 17, 92262 Fontenay-aux-Roses, France. henri.metivier@ipsn.fr
D000280:Administration, Inhalation; D000284:Administration, Oral; D000328:Adult; D026683:Advisory Committees; D001822:Body Burden; D002648:Child; D004064:Digestive System / Q000378:metabolism*; D006801:Humans; D007391:International Cooperation; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology*; D008954:Models, Biological; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D011829:Radiation Dosage; D011848:Radioactive Pollutants / Q000009:adverse effects / Q000032:analysis / Q000493:pharmacokinetics; D011868:Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects / Q000032:analysis / Q000493:pharmacokinetics*; D011874:Radiometry / Q000379:methods*; D018570:Risk Assessment / Q000379:methods*; D012952:Societies; D014018:Tissue Distribution
D011848:Radioactive Pollutants; D011868:Radioisotopes