Design and synthesis of A3 adenosine receptor ligands, 3'-fluoro analogues of Cl-IB-MECA.
Synthesis of 3'-deoxy-3'-fluoro-N6-substituted adenosines as bioisosteres of Cl-IB-MECA and their binding affinities to A3 adenosine receptor are described.
Kim
Hea Ok
HO
Division of Chemistry and Molecular Engineering, Seoul National University, Seoul, South Korea.
Lim
Moo Hong
MH
Park
Jae Gyu
JG
Moon
Hyung Ryong
HR
Jacobson
Kenneth A
KA
Kim
Hee-Doo
HD
Chun
Moon Woo
MW
Jeong
Lak Shin
LS
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D000818:Animals; D001921:Brain / Q000378:metabolism; D015195:Drug Design; D005459:Fluorides; D006801:Humans; D007202:Indicators and Reagents; D008024:Ligands; D015394:Molecular Structure; D011869:Radioligand Assay; D051381:Rats; D043684:Receptor, Adenosine A3 / Q000378:metabolism*
D007202:Indicators and Reagents; D008024:Ligands; D043684:Receptor, Adenosine A3; D000241:Adenosine; D005459:Fluorides; C090034:2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide