[Effect of phensuccinal on lipid metabolism, lipid peroxidation, and antioxidant system activity in rabbits with dithiazone-induced diabetes].
A three-month administration of phensuccinal improved glucose homeostasis, decreased the levels of total cholesterol, triglycerides, fatty acids, and low-density lipoproteins in the blood serum, and reduced the lipid peroxidation rate as compared to the untreated diabetic control. In addition, phensuccinal increased the content of the antiatherogenic high-density lipoprotein fraction and the related paraoxonase enzyme activity. The preventive effect of phensuccinal with respect to diabetic dyslipidemia development, together with the antioxidant action, show this compound to be a promising therapeutic means of preventing and/or reducing macrovascular complications in diabetic patients.
Gorbenko
N I
NI
Laboratory of Pathophysiology and Medical Genetics, Institute of Endocrine Pathology Problems, ul. Artema 10, 61002 Kharkov, Ukraine.
Poltorak
V V
VV
Gladkikh
A I
AI
Ivanova
O V
OV
D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000139:chemically induced / Q000378:metabolism*; D004230:Dithizone; D015227:Lipid Peroxidation / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008297:Male; D011817:Rabbits
D000447:Aldehydes; D000975:Antioxidants; D008055:Lipids; C419904:fensuccinal; D004230:Dithizone