[Comparative evaluation of effects of p-tyrosol and Rhodiola rosea extract on bone marrow cells in vivo].
The effects of p-tyrosol and Rhodiola rosea extract on the hemopoietic system were compared on a model of subacute lead intoxication. No significant differences between the activity of two preparations were revealed by the study of plasma membrane blebbing, apoptosis, and necrosis processes in bone marrow. At the same time, p-tyrosol exhibited a more pronounced effect upon lipid peroxidation and offered significant protection against lead intoxication.
Pashkevich
I A
IA
Department of Animal Anatomy and Physiology, Krasnoyarsk State Medical Agricultural University, pr. Mira 88, Krasnoyarsk, 660049 Russia.
Uspenskaia
Iu A
IuA
Nefedova
V V
VV
Egorova
A B
AB
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D009336:Necrosis; D009942:Organometallic Compounds / Q000633:toxicity; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D029771:Rhodiola / Q000737:chemistry*
D009942:Organometallic Compounds; D010936:Plant Extracts; C011867:4-hydroxyphenylethanol; D010626:Phenylethyl Alcohol; C008261:lead acetate