Development of an ophthalmic formulation containing ciprofloxacin-hydroxypropyl-b-cyclodextrin complex.
Ophthalmic formulations of ciprofloxacin were formulated using inclusion complexes of ciprofloxacin HCl (CFLX HCl) and hydroxypropyl-beta-cyclodextrin (HP-beta-CD). The complexes were prepared by the method of freeze drying and evaluated by phase solubility studies, differential scanning calorimetry, powder X-ray diffractiometry, fourier transform infrared spectroscopy and scanning electron microscopy. The ophthalmic solutions formulated using the complexed drug exhibited better stability, biological activity and ocular tolerance in comparison to another ophthalmic solution formulated using uncomplexed drug and also in comparison to a marketed preparation.
Nijhawan
R
R
Department of Pharmaceutics, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, India.
Agarwal
S P
SP
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000737:chemistry; D003505:Cyclodextrins; D004337:Drug Carriers; D004355:Drug Stability; D008855:Microscopy, Electron, Scanning; D009883:Ophthalmic Solutions; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins
D000890:Anti-Infective Agents; D003505:Cyclodextrins; D004337:Drug Carriers; D009883:Ophthalmic Solutions; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002939:Ciprofloxacin