title: Anti-HIV active petrosins from the marine sponge Petrosia similis.
abstract: A marine sponge Petrosia similis afforded two compounds which belongs to bis-quinolizidine alkaloids namely, petrosin (1) and petrosin-A (2), respectively. Petrosin (1) and petrosin-A (2) showed anti-HIV inhibition with IC(50) values of 41.3 and 52.9 microm respectively. MAGI cell assays indicated that the compounds inhibited early steps of HIV replication. In extracellular HIV-1 Reverse Transcriptase inhibition assay petrosin and petrosin-A inhibited HIV-1 RT at 10.6 and 14.8 microm. This is the first report of petroisns with anti-HIV activity.
authors.affiliation: Natural Products Laboratory, Organic Chemistry Division-I, Indian Institute of Chemical Technology, India.
authors.forename: Thirumani
authors.initials: T
authors.lastname: Venkateshwar Goud
authors.forename: Natala
authors.initials: N
authors.lastname: Srinivasa Reddy
authors.forename: Navath
authors.initials: N
authors.lastname: Raghavendra Swamy
authors.forename: Tejomoortula
authors.initials: T
authors.lastname: Siva Ram
authors.forename: Yenamandra
authors.initials: Y
authors.lastname: Venkateswarlu
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006367:HeLa Cells; D006801:Humans; D011161:Porifera
chemical_list: D019380:Anti-HIV Agents