RNAi on the apoptosis TRAIL: the mammalian cell genetic screen comes of age.
Presented in a paper in the September issue of Molecular Cell, Aza-Blanc et al. used an RNA interference-based genetic screen to identify genes that modulate sensitivity to the apoptosis-inducing ligand TRAIL. The age of mammalian cell genetic screens has begun.
Tewari
Muneesh
M
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Vidal
Marc
M
D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D034622:RNA Interference / Q000502:physiology*; D053221:TNF-Related Apoptosis-Inducing Ligand; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
D051017:Apoptosis Regulatory Proteins; D008562:Membrane Glycoproteins; D053221:TNF-Related Apoptosis-Inducing Ligand; C505653:TNFSF10 protein, human; D014409:Tumor Necrosis Factor-alpha