Synthesis of trans-L/D-2-(tert-butoxycarbonyl-aminomethyl)-4-(thymin-1-yl) pyrrolidin-1-yl acetic acid.
To delineate the binding preferences of stereochemically divergent pyrrolidine PNAs, synthesis of all four diastreomeric monomers of I and the systematic complexation studies of the resultant PNAs with complementary DNA/RNA is essential. We herein report the synthesis of trans-L/D-2-(tert-butoxycarbonyl-aminomethyl)-4-(thymin-1-yl) pyrrolidin-1-yl acetic acids I, their incorporation in PNA oligomers and DNA binding studies will be presented.
Kumar
Vaijayanti A
VA
Division of Organic Chemistry, National Chemical Laboratory, Pune, India. vkumar@dna.ncl.res.in
Meena
D000085:Acetates / Q000138:chemical synthesis*; D001483:Base Sequence; D004247:DNA / Q000737:chemistry; D006860:Hydrogen Bonding; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry; D011759:Pyrrolidines / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013941:Thymine / Q000031:analogs & derivatives* / Q000737:chemistry
D000085:Acetates; D009838:Oligodeoxyribonucleotides; D020135:Peptide Nucleic Acids; D011759:Pyrrolidines; C479431:trans-2-(tert-butoxycarbonyl-aminomethyl)-4-(thymin-1-yl) pyrrolidin-1-yl acetic acid; D004247:DNA; D013941:Thymine