Influenza B pneumonia with Staphylococcus aureus superinfection associated with parvovirus B19 and concomitant agranulocytosis.
An 11-year-old patient with anamnestic fever for 3 days and signs of upper respiratory tract infection underwent fulminant Staphylococcus aureus pneumonia with concomitant agranulocytosis. From autopsia influenza B virus and parvovirus B19 were detected by nucleic acid amplification technique (NAT). Specific IgG but no IgM points to preexisting parvovirus B19 infection. Whether in this case agranulocytosis can be interpreted as early manifestation of reactivated parvovirus B19 infection is under discussion. Therefore, parvovirus B19 could have provoked a foudroyant course of influenza B pneumonia which was superinfected with S. aureus.
Krell
S
S
Institute of Medical Microbiology, Medical Faculty, Otto von Guericke University Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany. krell@gee.ladr.de
Adams
I
I
Arnold
U
U
Kalinski
T
T
Aumann
V
V
König
W
W
König
B
B
D000380:Agranulocytosis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D001344:Autopsy; D002648:Child; D003131:Combined Modality Therapy; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D009981:Influenza B virus / Q000302:isolation & purification*; D008168:Lung / Q000473:pathology; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications / Q000175:diagnosis*; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D011024:Pneumonia, Viral / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D012131:Respiratory Insufficiency / Q000175:diagnosis / Q000209:etiology; D012720:Severity of Illness Index; D015163:Superinfection / Q000150:complications / Q000382:microbiology* / Q000628:therapy