Vitamin D3-dependent pathway regulates TACO gene transcription.
Recently, gene coding for tryptophan-aspartate containing coat protein (TACO) has been recognized to play a crucial role in the survival of Mycobacterium tuberculosis within human macrophages. Since regulation of TACO gene is still poorly understood, the present study was addressed to explore the role of vitamins (A, C, D, and E) in TACO gene transcription. Such a study revealed that synergistic action of vitamin D(3) and retinoic acid (RA) had inherent ability to down-regulate TACO gene transcription in human macrophages. Based upon these results, we propose that synergistic action of RA+vitamin D may be of importance in the prevention/control of M. tuberculosis infection.
Anand
Paras K
PK
Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Kaul
Deepak
D
D002762:Cholecalciferol / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008264:Macrophages / Q000378:metabolism / Q000382:microbiology; D008840:Microfilament Proteins; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D011110:Polymorphism, Genetic; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics*; D012313:RNA / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000235:genetics; D014158:Transcription, Genetic; D014212:Tretinoin / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism
D008840:Microfilament Proteins; D011506:Proteins; D018167:Receptors, Calcitriol; D014807:Vitamin D; C072061:coronin proteins; D002762:Cholecalciferol; D014212:Tretinoin; D012313:RNA