Hyperoxic condition prevents bacterial translocation and elevation of plasma microorganism components during hemorrhagic shock.
To evaluate the influence of hyperoxic conditions on bacterial translocation (BT) and microorganism components during hemorrhagic shock, rats were divided into a group breathing 100% oxygen and a group breathing room air. The groups were then subjected to hemorrhagic shock. Systemic blood and mesenteric lymph nodes were cultured for BT, and systemic plasma concentrations of microorganism components were measured by the silkworm larvae plasma (SLP) test and the endotoxin test. Hyperoxic conditions prevented both BT and plasma SLP-reactive substance (peptidoglycan and beta-glucan) elevation during hemorrhagic shock. Our findings suggest that hyperoxic treatment might improve host conditions during hemorrhagic shock.
Endo
Yoshihiro
Y
Department of Surgery, Shiga University of Medical Science, Otsu-shi Shiga, Japan.
Shimizu
Tomoharu
T
Mori
Tsuyoshi
T
Tabata
Takahisa
T
Hanasawa
Kazuyoshi
K
Tsuchiya
Masakazu
M
Tani
Tohru
T
D000818:Animals; D016470:Bacteremia / Q000517:prevention & control*; D018988:Bacterial Translocation / Q000502:physiology*; D001784:Blood Gas Analysis; D004731:Endotoxins / Q000097:blood; D005936:Glucans / Q000378:metabolism; D018496:Hyperoxia / Q000382:microbiology*; D008198:Lymph Nodes / Q000382:microbiology; D010457:Peptidoglycan / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012771:Shock, Hemorrhagic / Q000382:microbiology*; D047071:beta-Glucans
D004731:Endotoxins; D005936:Glucans; D010457:Peptidoglycan; D047071:beta-Glucans; C064197:beta-1,6-glucan