Content of autoantibodies to bradykinin and beta-amyloid(1-42) as a criterion for biochemical differences between Alzheimer's dementias.
We measured serum content of autoantibodies to beta-amyloid protein Abeta(1-42), its neurotoxic fragment Abeta(25-35), vasopressin, bradykinin, thrombin, antithrombin III, alpha(2)-macroglobulin, and angiotensin II in patients with various forms of Alzheimer's dementias, including presenile and senile dementias of the Alzheimer type. The ratio of antibradykinin and anti-Abeta(1-42) autoantibody contents differed by 39% in these patients. Our results can be used for the development of a new biochemical method for differential diagnostics of dementias of the Alzheimer type.
Myagkova
M A
MA
Department of Biochemical Assays, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka.
Gavrilova
S I
SI
Lermontova
N N
NN
Kalyn
Ya B
YB
Selezneva
N D
ND
Zharikov
G A
GA
Kolykhalov
I V
IV
Abramenko
T V
TV
Serkova
T P
TP
Bachurin
S O
SO
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000276:immunology / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000737:chemistry*; D000990:Antithrombin III / Q000737:chemistry; D001323:Autoantibodies / Q000097:blood*; D001920:Bradykinin / Q000737:chemistry*; D006801:Humans; D008875:Middle Aged; D009498:Neurotoxins / Q000737:chemistry; D010446:Peptide Fragments / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry; D013917:Thrombin / Q000737:chemistry; D014667:Vasopressins / Q000737:chemistry; D000511:alpha-Macroglobulins / Q000737:chemistry
D016229:Amyloid beta-Peptides; D001323:Autoantibodies; D009498:Neurotoxins; D010446:Peptide Fragments; D010455:Peptides; D000511:alpha-Macroglobulins; C075222:amyloid beta-protein (1-42); C074636:amyloid beta-protein (25-35); D014667:Vasopressins; D000990:Antithrombin III; D013917:Thrombin; D001920:Bradykinin