[Prognostic value of the pronuclear morphology pattern of zygotes for implantation rate].
BACKGROUND
In ICSI and conventional IVF cycles, the embryos are usually selected for transfer based on evaluation of the cleavage speed and the extent of blastomere fragmentation. Pronuclear stage scoring system has been used in IVF recently as an additional parameter.


OBJECTIVE
The aim of this study was to classify embryos from ICSI cycles according to the pronuclear scoring system and its influence on implantation rate.


METHODS
62 couples suffering from different types of infertility and treated by ICSI were included in our study. For each embryo, the following data were analyzed: pronuclei (PN) morphology, 16-20 hours after ICSI, and embryo morphology, about 40-42 (day 2) and 65-68 (day 3) hours after ICSI. The embryo transfer was performed on the third day after pick-up.


RESULTS
In 55 (88.7%) cases we transferred at least one embryo from the zygotes of 0 or 1 or 2 pattern. The implantation rate was 30.6% (n = 19). In all of these cases the embryos have been derived from zygotes from pattern 0, 1 or 2.


CONCLUSIONS
Pronuclear scoring system of zygotes appears to be a predictor of the implantation potential. Embryos derived from pattern 0, 1 and 2 of zygotes implant at a higher rate (p = 0.05).
Łukaszuk
Krzysztof
K
Zakładu Endokrynologii Ginekologicznej, Instytutu Połoznictwa i Chorób Kobiecych, Akademii Medycznej, Poradni Wspomaganego Rozrodu, Niepubliczny Zakład Opieki Zdrowotnej INVICTA w Gdańsku.
Liss
Joanna
J
Białobrzeska
Dorota
D
Wójcikowski
Czesław
C
D000328:Adult; D001755:Blastocyst / Q000502:physiology* / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D002970:Cleavage Stage, Ovum; D010064:Embryo Implantation; D004624:Embryo Transfer; D004622:Embryo, Mammalian / Q000502:physiology* / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007246:Infertility / Q000628:therapy; D008297:Male; D011237:Predictive Value of Tests; D011247:Pregnancy; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods; D015053:Zygote / Q000502:physiology* / Q000648:ultrastructure*; D017388:Zygote Intrafallopian Transfer / Q000379:methods