title: Familial spontaneous pneumothorax in three generations and its HLA.
abstract: We experienced a case of familial spontaneous pneumothorax in three generations. Six of 13 family members had episodes of spontaneous pneumothorax. It is well established that there are some diseases associated with human leukocyte antigen (HLA). We performed HLA phenotyping for HLA of A, B and C. In our study, we detected the HLA haplotype A2, B61 in three of 4 who had episodes of spontaneous pneumothorax. The HLA haplotype A2, B70 were also detected in three of 4 who had episodes. This suggests that familial spontaneous pneumothorax might have hereditary factors.
authors.affiliation: Department of Surgery, Suma Red Cross Hospital, Kobe, Hyogo, Japan.
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Yamada
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Takeda
authors.forename: Satoru
authors.initials: S
authors.lastname: Hayashi
authors.forename: Kazuta
authors.initials: K
authors.lastname: Shimizu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011030:Pneumothorax / Q000235:genetics*
chemical_list: D006680:HLA Antigens