title: [Clinical observation of the treatment of 654-2 injection and "ganxian tui huang recipe" on liver cirrhosis with intractable jaundice].
abstract: OBJECTIVE
  To observe the effect of 654-2 injection and "GanXian Tui Huang Recipe" on hepatic fibrosis with intractable jaundice.
  
  
  METHODS
  60 patients were treated for 3 months and randomly divided into control group and experiment group. The experiment group was treated with 654-2 injection and "Gan Xian Tui Huang Recipe" and the control group was treated with routine treatment. All the patients have high level of Nitrogen monoxide(NO), hyaluronic acid(HA > 400 ng/ml) and hepatic fibrosis with intractable jaundice.
  
  
  RESULTS
  In experiment group, the serum total bilirubin(TB), globulin(GLB), HA and NO were significantly decreased to normal level; 40% of portal veins were narrowed, 50% of them were not changed; 30% of spleen were thinned, 40% of them were fixed. 1 year later, 20 patients were stable and 2 patients were recurrent in 22 patients of the experiment group; in 24 patients of the control group, 7 patients were stable, 10 patients had hypersplenia, 2 patients occurred hepatocarcinoma and 5 patients were recurrent.
  
  
  CONCLUSIONS
  Effect of 654-2 injection and "Gan Xian Tui Huang Recipe" on hepatic fibrosis with intractable jaundice is significant.
authors.affiliation: Third Hospitasl Affiliated Sun Yat-Sen University, Guangzhou 510630.
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Yang
authors.forename: Kangshou
authors.initials: K
authors.lastname: Guo
authors.forename: Weisheng
authors.initials: W
authors.lastname: Shen
authors.forename: Yongwei
authors.initials: Y
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Dai
mesh_terms: D000328:Adult; D000368:Aged; D004338:Drug Combinations; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007565:Jaundice / Q000188:drug therapy* / Q000209:etiology; D008103:Liver Cirrhosis / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry; D012991:Solanaceous Alkaloids / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D012991:Solanaceous Alkaloids; C003922:anisodamine