title: Determination of chromium and selected elements in multimineral and multivitamin preparations and in pharmaceutical raw material.
abstract: The content of elements in pharmaceutical preparations is one of the indispensable factors of the evaluation of their quality. In the present work, the following macro- and microelements Ca, Cr, Cu, Fe, Mg, Mn, Mo, P, Se and Zn were determined in multimineral and multivitamin preparations and in pharmaceutical raw material. Inductively coupled plasma mass spectrometry (ICP-MS) and electrothermal atomic absorption spectrometry (ET AAS) were used throughout the study. The examined samples were dissolved in a high-pressure microwave system using concentrated nitric acid. The effect of the carbon residue in the digest solution on the determination result was eliminated by introducing an equation correcting the ArC+ interference with 52Cr.
authors.affiliation: Department of Pharmaceutical Chemistry, Drug Institute, 30/34 Chełmska Str., 00-725 Warsaw, Poland.
authors.forename: Krystyna
authors.initials: K
authors.lastname: Sołtyk
authors.forename: Anna
authors.initials: A
authors.lastname: Lozak
authors.forename: Peter
authors.initials: P
authors.lastname: Ostapczuk
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Fijałek
mesh_terms: D000880:Anthraquinones / Q000032:analysis; D002118:Calcium / Q000032:analysis; D002214:Capsules / Q000032:analysis; D000460:Chlorophyta / Q000737:chemistry; D002857:Chromium / Q000032:analysis*; D019587:Dietary Supplements / Q000032:analysis*; D007202:Indicators and Reagents; D007501:Iron / Q000032:analysis; D021241:Spectrometry, Mass, Electrospray Ionization; D013054:Spectrophotometry, Atomic; D013607:Tablets / Q000032:analysis; D014815:Vitamins / Q000032:analysis*
chemical_list: D000880:Anthraquinones; D002214:Capsules; D007202:Indicators and Reagents; D013607:Tablets; D014815:Vitamins; D002857:Chromium; C025292:diacerein; D007501:Iron; D002118:Calcium