COMET: a proposed mechanism of action to explain the results and concerns about dose.
Wikstrand
J
J
Fagerberg
B
B
Goldstein
S
S
Kjekshus
J
J
Wedel
H
H
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008790:Metoprolol / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists; D008790:Metoprolol