Skin rash and splinter hemorrhages from ganciclovir.
Ganciclovir is a nucleotide-analogue similar to acyclovir, which has an in vitro activity against herpes simplex type 1, herpes simplex type 2 and varicella zoster virus. Numerous studies suggest that ganciclovir has clinical efficacy against cytomegalovirus disease, as well as an in vivo antiviral effect, and that this agent reduces morbidity of serious cytomegalovirus infections in immunocompromised patients. Generalised cutaneous rash associated with ganciclovir therapy has rarely been reported in literature.
Lorenzi
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Department of Dermatology, University of Bologna, Via Massarenti, Bologna, Italy.
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Iorizzo
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Tosti
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D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy*; D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects*; D003586:Cytomegalovirus Infections / Q000188:drug therapy*; D005076:Exanthema / Q000139:chemically induced*; D017809:Fatal Outcome; D005260:Female; D015774:Ganciclovir / Q000009:adverse effects*; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans
D000998:Antiviral Agents; D015774:Ganciclovir