Oligomerization aiming at phosphonate analogues of oligoadenylates.
This work deals with isopolar, phosphonate-based nucleotide analogues containing a bridging P-C bond instead of the ester P-O linkage. Specifically, starting from activated derivatives 1, 2, and 3, a simple process for preparation of mixtures of short oligomers and their analyses were elaborated.
Pressová
Martina
M
Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague, Czech Republic.
Liboska
Radek
R
Budesínský
Milos
M
Králíková
Sárka
S
Kavenová
Ivana
I
Rosenberg
Ivan
I
D000227:Adenine Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D007202:Indicators and Reagents; D015394:Molecular Structure; D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D063065:Organophosphonates; D016047:Zalcitabine
D000227:Adenine Nucleotides; D007202:Indicators and Reagents; D009843:Oligoribonucleotides; D063065:Organophosphonates; C023505:2',5'-oligoadenylate; D016047:Zalcitabine