Prognostic factors and risk-based therapy in pediatric acute myeloid leukemia.
Acute myelocytic leukemia (AML) is a heterogeneous disease that accounts for nearly a quarter of the pediatric leukemias. Despite near myeloablative therapy, half of patients relapse and die from their disease. Identification of patients at high risk of relapse early in the course of treatment may allow for treatment modification to improve their outcome. In addition, patients at lower risk of relapse may benefit from treatment de-escalation, sparing them adverse side effects. This review describes prognostic factors that play a major role in the outcome of children with AML and their potential use for treatment stratification in pediatric AML trials.
Meshinchi
Soheil
S
Fred Hutchinson Cancer Center, Seattle, WA, USA.
Smith
Franklin O
FO
Arceci
Robert J
RJ
D000208:Acute Disease; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D006648:Histocompatibility; D006801:Humans; D007951:Leukemia, Myeloid / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D011379:Prognosis; D012307:Risk Factors; D033581:Stem Cell Transplantation
D000970:Antineoplastic Agents