title: The synthesis and applications of 5-aminolevulinic acid (ALA) derivatives in photodynamic therapy and photodiagnosis.
abstract: A route has been developed to high-purity precursors, viz., ALA esters, to be used in photodiagnosis and photodynamic therapy. Hexyl, butyl and methyl 5-aminolevulinates are similar to the ALA acid in chemical stability and efficacy in producing the appropriate photosensitizer PpIX. Tests carried out on animal models showed the method based on the esters to be the more selective.
authors.affiliation: Industrial Chemistry Research Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Dabrowski
authors.forename: Mirosław
authors.initials: M
authors.lastname: Kwaśny
authors.forename: Jarosław
authors.initials: J
authors.lastname: Kamiński
authors.forename: Maria
authors.initials: M
authors.lastname: Bełdowicz
authors.forename: Lidia
authors.initials: L
authors.lastname: Lewicka
authors.forename: Bozena
authors.initials: B
authors.lastname: Obukowicz
authors.forename: Miron
authors.initials: M
authors.lastname: Kaliszewski
authors.forename: Ewa
authors.initials: E
authors.lastname: Pirozyńska
mesh_terms: D000622:Aminolevulinic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D004355:Drug Stability; D005453:Fluorescence; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D051379:Mice; D008807:Mice, Inbred BALB C; D009214:Myoma / Q000473:pathology / Q000628:therapy; D009368:Neoplasm Transplantation; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D007202:Indicators and Reagents; D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid