Distribution of anxiogenic-induced c-Fos in the forebrain regions of developing rats.
An anxiogenic or a pharmacological stressor, N-methyl-beta-carboline-3-carboxamide (FG-7142), (20 mg/kg, intraperitoneally injected) induced a dense nuclear c-Fos-like immunoreactivity in the pyriform cortex, cingulate and retrosplenial cortex, layers II-VI of the neocortex, lateral habenula, lateral septum, paraventricular nucleus of the thalamus, striatum, central and medial nucleus of the amygdala, but a sparse c-Fos immunostaining in the hippocampus and layer I of the neocortex in the forebrain of 56-day-old rats. Among these regions, the 8-day-old rats expressed much fewer c-Fos-positive cells in the neocortex, lateral habenula, lateral septum and medial nucleus of the amygdala than the young adult rats following the FG-7142 injection. These differences in the regional distribution of a neuronal activity marker, c-Fos, could reflect the postnatal development of neuronal populations or neuron circuits involved in stress and/or emotional response in the forebrain.
Kurumaji
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A
Section of Psychiatry and Behavioral Sciences, Tokyo Medical and Dental University Graduate School, Tokyo, Japan.
Umino
A
A
Tanami
M
M
Ito
A
A
Asakawa
M
M
Nishikawa
T
T
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001007:Anxiety / Q000378:metabolism; D002243:Carbolines / Q000494:pharmacology*; D018756:GABA Antagonists / Q000494:pharmacology*; D007150:Immunohistochemistry; D008297:Male; D016548:Prosencephalon / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D016760:Proto-Oncogene Proteins c-fos / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000378:metabolism
D002243:Carbolines; D018756:GABA Antagonists; D016760:Proto-Oncogene Proteins c-fos; C035874:FG 7142