title: Analysis on pathogenesis of 50 cases of bladder proliferative lesions.
abstract: In order to study the pathogenesis, clinical and pathological characteristics of proliferative lesions of the bladder, 50 cases of proliferative lesions of the bladder from 150 patients with complaints of frequency, urgency, hematuria and dysuria were subjected to cystoscopic biopsy of the suspicious foci in the bladder. In combination with the symptoms, urine and urodynamics, the relationship of proliferative lesions of the bladder to the inflammation and obstruction of the lower urinary tract was analyzed. Of the 50 cases of proliferative bladder lesions, 44 cases (88%) had lower urinary tract infection and 29 (58%) lower urinary tract obstruction. The patients with lower urinary tract obstruction were all complicated with infection. Three cases were associated with transitional cell carcinoma. Malignant cells were detected in 1 case by urinary cytologic examination. Proliferative lesions of the bladder, especially those without other obvious mucosa changes under cystoscopy, are common histological variants of urothelium in the patients with chronic inflammation and obstruction of the lower urinary tract. Chronic inflammation and obstruction of the lower urinary tract might be the causes for proliferative lesions of the bladder. It is suggested that different treatments should be applied according to the scope and histological type of the proliferative lesions.
authors.affiliation: Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Chen
authors.forename: Ruzhu
authors.initials: R
authors.lastname: Lan
authors.forename: Zhangqun
authors.initials: Z
authors.lastname: Ye
authors.forename: Weimin
authors.initials: W
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D003556:Cystitis / Q000150:complications*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology*; D001743:Urinary Bladder / Q000473:pathology*; D001745:Urinary Bladder Diseases / Q000209:etiology* / Q000473:pathology; D001748:Urinary Bladder Neck Obstruction / Q000150:complications*; D014555:Urination Disorders / Q000150:complications; D014563:Urodynamics / Q000502:physiology