2'-Deoxy-2'-C-trifluoromethyl beta-D-ribonucleoside analogues: synthesis and antiviral evaluations.
Hitherto unknown 2'-deoxy-2'-C-trifluoromethyl-beta-D-ribonucleoside derivatives bearing the five naturally occurring nucleic acid bases have been synthesized. The compounds were tested for their activity against HIV, HBV and several RNA viruses, but they did not show significant antiviral effect.
Jeannot
Frédéric
F
Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS, Université Montpellier II, Montpellier, France.
Gosselin
Gilles
G
Mathé
Christophe
C
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006678:HIV / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects; D012328:RNA Viruses / Q000187:drug effects; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology
D000998:Antiviral Agents; D012263:Ribonucleosides