title: Lithium dose prediction based on 24 hours single dose levels: a prospective evaluation.
abstract: The authors present the results of the utilization of a pharmacokinetic prediction test for lithium posology. Based on a single point (plasma lithium determination 24 h after a single dose) such a test aims to adapt the posology as soon as the second day of treatment rather than after one week as clinicians must wait for a steady state to be achieved. Built on the previous work of Perry, the test targeted the plasma lithium level at 0.8 +/- 0.1 mmol l(-1). Thirty-one patients took part in the study. There were two drop-out cases and the results were available for 29 patients: among them, 51% had their plasma level in the targeted zone. Although there was no control group, the prediction test often allowed us to use a higher dose than the usual fixed dose whose amount is limited by the risk of overdosing for the slower metabolizers.
authors.affiliation: Département de Psychiatrie, Clinique de Psychiatrie Adulte-Programme Dépression, Hôpitaux Universitaires de Genève, Domaine de Belle-Idée, 16-18, bd Saint-Georges, CH-1205 Geneva, Switzerland. Nicola.Gervasoni@hcuge.ch
authors.forename: N
authors.initials: N
authors.lastname: Gervasoni
authors.forename: M-P
authors.initials: MP
authors.lastname: Zona-Favre
authors.forename: Ch
authors.initials: Ch
authors.lastname: Osiek
authors.forename: L
authors.initials: L
authors.lastname: Roth
authors.forename: G
authors.initials: G
authors.lastname: Bondolfi
authors.forename: G
authors.initials: G
authors.lastname: Bertschy
mesh_terms: D000328:Adult; D000465:Algorithms; D000928:Antidepressive Agents / Q000009:adverse effects / Q000097:blood* / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007700:Kinetics; D016651:Lithium Carbonate / Q000009:adverse effects / Q000097:blood* / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000188:drug therapy* / Q000378:metabolism; D010352:Patient Dropouts; D011446:Prospective Studies; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced
chemical_list: D000928:Antidepressive Agents; D016651:Lithium Carbonate