Pyrrolidine PNA-DNA chimeric oligonucleotides with extended backbone.
Cis-D-2-hydroxy-4-thymin-1-yl-pyrrolidine propionic acid unit is used to make PNA-DNA dimer block that is incorporated in DNA sequences at selected positions. Since the amide linkage is shorter than phosphodiester linkage, insertion of an extra atom in the backbone with amide linkage seems to be better accommodated for internucleotide distance-complementarity.
Kumar
Vaijayanti A
VA
Division of Organic Chemistry, National Chemical Laboratory, Pune, India. vkumar@dna.ncl.res.in
Meena
D001483:Base Sequence; D001665:Binding Sites; D002678:Chimera; D004247:DNA / Q000737:chemistry*; D006860:Hydrogen Bonding; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D011759:Pyrrolidines; D013941:Thymine / Q000031:analogs & derivatives*
D009838:Oligodeoxyribonucleotides; D020135:Peptide Nucleic Acids; D011759:Pyrrolidines; D004247:DNA; D013941:Thymine