title: Mononucleoside SATE glucosyl phosphorothiolates as a new series of pronucleotides.
abstract: The synthesis and the study of two phosphorothiolate derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) bearing a S-pivaloyl-2-thioethyl (tBuSATE) group and glucosyl residues associated to the phosphorus atom by a 2-oxyethyl link, are reported. These derivatives could be considered as prototypes of a new series of nucleotide prodrugs (pronucleotides).
authors.affiliation: Université Montpellier II, UMR 5625 CNRS, Montpellier, France.
authors.forename: A
authors.initials: A
authors.lastname: Jochum
authors.forename: N
authors.initials: N
authors.lastname: Schlienger
authors.forename: G
authors.initials: G
authors.lastname: Gosselin
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
authors.forename: A M
authors.initials: AM
authors.lastname: Aubertin
authors.forename: C
authors.initials: C
authors.lastname: Périgaud
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry; D015215:Zidovudine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D011355:Prodrugs; D015215:Zidovudine