title: Two fatal cases involving concurrent use of methamphetamine and morphine.
abstract: We report on two cases of simultaneous administration of methamphetamine (MAP) and morphine (MOR) with hyperthermia. The blood levels of MAP and MOR were toxic and putatively lethal, respectively, although hyperthermia is a known cause of intoxication due to MAP rather than MOR. In Japan, MAP is the most predominant cause of drug intoxication. The presented cases suggest that MOR may exert synergistic effect on hyperthermia due to the MAP intoxication, together with experimental findings.
authors.affiliation: Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan. kuemura@m.u-tokyo.ac.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Uemura
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Sorimachi
authors.forename: Mikio
authors.initials: M
authors.lastname: Yashiki
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Yoshida
mesh_terms: D000328:Adult; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000506:poisoning*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008694:Methamphetamine / Q000506:poisoning*; D009020:Morphine / Q000008:administration & dosage / Q000506:poisoning*; D009294:Narcotics / Q000008:administration & dosage / Q000506:poisoning*
chemical_list: D000697:Central Nervous System Stimulants; D009294:Narcotics; D008694:Methamphetamine; D009020:Morphine