title: [Research development of hydroxyapatite-based composites used as hard tissue replacement].
abstract: Hydroxyapatite has been considered as the most promising materials for hard tissue replacements, due to its similar chemical composition and crystallographic structure to that of bone mineral. But the brittleness is one of the most serious obstacles for its wider applications as load-bearing implants. Therefore, various HA composites get much attention. In the present paper, HA composites were introduced according to the kind of reinforcement. Although bioactive ceramics, bioactive glass or glass-ceramic, bio-inactive ceramics, polymers and metals all have been used to fabricate HA composites, no one can well satisfy the requirements for hard tissue replacement. The vital problem of the existing HA composites is that the biological properties cannot match with the mechanical properties well.
authors.affiliation: Department of Orthopaedics, Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011.
authors.forename: Congqin
authors.initials: C
authors.lastname: Ning
authors.forename: Kerong
authors.initials: K
authors.lastname: Dai
mesh_terms: D000537:Aluminum Oxide / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry* / Q000145:classification; D018786:Bone Substitutes; D002516:Ceramics / Q000737:chemistry; D015921:Dental Implants; D017886:Durapatite / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D015921:Dental Implants; D011108:Polymers; C023506:Glass ceramics; D017886:Durapatite; D000537:Aluminum Oxide