[Preparation and biological evaluation of PLA/chitosan composite materials].
Hypersusceptibility test, pyrogen test, cell cultivation, and toxicity examination were applied in the biological evaluation of the poly(lactic acid) (PLA)/chitosan composite materials. The results indicated that all the materials were negative, conforming to the ISO10993-1. The cell could grow well on the surface of the materials. So the PLA/chitosan composite materials have good biocompatibility and can be planted in the body as scaffolds.
Li
Lihua
L
Biomaterials Research Lab, Chemistry Department, Jinan University, Guangzhou 510630.
Ding
Shan
S
Zhou
Changren
C
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000633:toxicity*; D002448:Cell Adhesion / Q000187:drug effects* / Q000502:physiology; D002478:Cells, Cultured; D002686:Chitin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000633:toxicity*; D048271:Chitosan; D005260:Female; D006168:Guinea Pigs; D019344:Lactic Acid / Q000138:chemical synthesis / Q000633:toxicity*; D008297:Male; D008422:Materials Testing; D011091:Polyesters; D011108:Polymers / Q000138:chemical synthesis / Q000633:toxicity*; D011817:Rabbits
D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D002686:Chitin; D019344:Lactic Acid; C033616:poly(lactide); D048271:Chitosan