Synthesis and biological evaluation of beta-D-pentofuranonucleoside derivatives of 2-azidoadenine and 6-azidopurines.
Beta-D-pentofuranonucleoside derivatives of 2-azidoadenine and 6-azidopurines have been synthesized. The azido-tetrazolo tautomerism observed on such nucleoside analogues has been studied. The compounds were tested for their activity against HIV and HBV but they did not show significant antiviral effect.
Mathé
Christophe
C
Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-Université Montpellier II, Montpellier, France. cmathe@univ-montp2.fr
Lioux
Thierry
T
Gosselin
Gilles
G
D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001386:Azides / Q000138:chemical synthesis; D006678:HIV / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D011687:Purines / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
D019380:Anti-HIV Agents; D000998:Antiviral Agents; D001386:Azides; D007202:Indicators and Reagents; D011687:Purines; D000225:Adenine