Synthesis of new homo and heterodimers of 2',3'-dideoxyinosine (ddI) using ester linkages.
A series of new homo and heterodimers of ddI has been synthesized. A glutarate diester spacer was used to covalently couple ddI onto ddI, AZT or d4T.
Ait Mohamed
L
L
Laboratoire de Chimie Bio-Organique, Faculté des Sciences, Semlalia, Marrakech, Morocco.
Taourirte
M
M
Rochdi
A
A
Lazrek
H B
HB
Vasseur
J J
JJ
Engels
J W
JW
Pannecouque
C
C
De Clercq
E
E
D019380:Anti-HIV Agents / Q000737:chemistry; D016049:Didanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D019281:Dimerization; D004952:Esters; D007202:Indicators and Reagents; D008968:Molecular Conformation; D018119:Stavudine / Q000737:chemistry; D015215:Zidovudine / Q000737:chemistry
D019380:Anti-HIV Agents; D004952:Esters; D007202:Indicators and Reagents; D015215:Zidovudine; D018119:Stavudine; D016049:Didanosine