title: Diagnostic usefulness of carotid pulse tracing in patients with hypertrophic obstructive cardiomyopathy due to midventricular obstruction: a comparison with idiopathic hypertrophic subaortic stenosis.
abstract: OBJECTIVE
  Of the hypertrophic obstructive cardiomyopathies, midventricular obstruction (MVO) often has been overlooked. In this study, hemodynamic parameters in patients with MVO were compared with patients with idiopathic hypertrophic subaortic stenosis (IHSS), following which the specific markers for diagnosis of MVO were examined.
  
  
  METHODS
  Twenty healthy control subjects (mean [+/- SD] age, 54 +/- 8 years), 20 patients with MVO (mean age, 54 +/- 13 years), and 12 patients with IHSS (mean age, 58 +/- 12 years) participated in this study. Hemodynamic parameters associated with carotid pulse tracing (CPT) and echocardiography were examined.
  
  
  RESULTS
  Left ventricular ejection time (LVET) and left ventricular pressure gradient (LVPG) were greater in patients with IHSS than in patients with MVO (p < 0.0001 for both). However, left ventricular dimensions and interventricular septal thickness did not vary between patients with MVO and those with IHSS. As specific markers for the diagnosis of patients with MVO, two specific CPT patterns, the "spike-and-dip pattern" and the "spike-and-half-dome pattern," were identified, but no specific markers were observed echocardiographically. Among patients with MVO, both LVPG and LVET were greater in patients with the spike-and-half-dome pattern than in patients with the spike-and-dip pattern (113 +/- 34 vs 57 +/- 17 mm Hg, respectively [p < 0.0001]; 318 +/- 19 vs 281 +/- 27 ms, respectively [p = 0.0033]), but echocardiographic parameters revealed no significant differences between the two types of MVOs. The pattern of continuous-wave Doppler recordings of the left ventricle in patients with the spike-and-half-dome pattern was identical to that of patients with IHSS, but that of patients with the spike-and-dip pattern exhibited concavity from the onset of systole to the point of maximal velocity.
  
  
  CONCLUSIONS
  Two specific patterns for the diagnosis of patients with MVO were identified by CPT. These patterns may be strongly related to differences in ejection dynamics.
authors.affiliation: Second Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan. mhamada@m.ehime-u.ac.jp
authors.forename: Mareomi
authors.initials: M
authors.lastname: Hamada
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shigematsu
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Ohshima
authors.forename: Jun
authors.initials: J
authors.lastname: Suzuki
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Ogimoto
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ohtsuka
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hara
mesh_terms: D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis*; D002339:Carotid Arteries; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D011674:Pulse; D014694:Ventricular Outflow Obstruction / Q000150:complications* / Q000175:diagnosis*