title: 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaB.
abstract: The aim of this study was to evaluate, using a rat model of balloon angioplasty, whether prostaglandin (PG) J(2) and 2-cyclopenten-1-one are able to reduce restenosis. We found that both PGJ(2) and 2-cyclopenten-1-one, administered by local application on carotid arteries, caused a dose-dependent inhibition of neointimal formation. Furthermore, both agents prevented vascular negative remodeling. The effect of these compounds on restenosis was correlated with an inhibition of nuclear factor-kappaB (NF-kappaB) activation as well as of intercellular adhesion molecule-1 (ICAM-1) protein expression in injured carotid arteries of control animals. Our results show that cyclopentenone PGs and their derivatives reduce restenosis and may have therapeutic relevance for the prevention of human restenosis.
authors.affiliation: Department of Experimental Pharmacology, University of Naples Federico II, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Ianaro
authors.forename: Pasquale
authors.initials: P
authors.lastname: Maffia
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cuzzocrea
authors.forename: Elena
authors.initials: E
authors.lastname: Mazzon
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Santoro
authors.forename: Massimo
authors.initials: M
authors.lastname: Di Rosa
authors.forename: Armando
authors.initials: A
authors.lastname: Ialenti
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D023903:Coronary Restenosis / Q000188:drug therapy* / Q000378:metabolism*; D003517:Cyclopentanes / Q000494:pharmacology / Q000627:therapeutic use*; D024202:Electrophoretic Mobility Shift Assay; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008297:Male; D016328:NF-kappa B / Q000378:metabolism*; D015230:Prostaglandin D2 / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D017539:Tunica Intima / Q000187:drug effects / Q000473:pathology
chemical_list: D003517:Cyclopentanes; D016328:NF-kappa B; D018799:Intercellular Adhesion Molecule-1; C037112:9-deoxy-delta-9-prostaglandin D2; C013905:cyclopentenone; D015230:Prostaglandin D2