Cell death during lymphocyte development and activation.
The development and homeostasis of the immune system requires an exquisite balance between cell proliferation and cell death. In this review, we discuss several in vivo and in vitro models that have been developed to help understand the importance of apoptosis during B and T cell development and activation.
de Alborán
Ignacio Moreno
IM
Department of Immunology and Oncology, Centro Nacional de Biotecnología/CSIC, UAM Campus de Cantoblanco, E-28049 Madrid, Spain.
Robles
María S
MS
Bras
Alexandra
A
Baena
Esther
E
Martínez-A
Carlos
C
D000818:Animals; D017209:Apoptosis; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D002454:Cell Differentiation; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism