title: Isolated cardiomegaly in the second trimester as an early sign of fetal hydrops due to intracranial arteriovenous malformation.
abstract: We report the case of a 27-year-old pregnant woman in whom isolated mild fetal cardiomegaly, diagnosed prenatally on sonographic examination at 22 weeks' menstrual age, was the first sign of development of an arteriovenous malformation of the vein of Galen. The arteriovenous malformation was visualized on sonographic examination at 29 weeks' menstrual age; prenatal MRI at 32 weeks confirmed the diagnosis. At 34 weeks' menstrual age, repeat sonographic examination demonstrated polyhydramnios, cardiomegaly, and generalized hydrops with ascites and pleural effusion. After vaginal delivery, the male neonate died of respiratory distress. We present the findings of prenatal gray-scale, color Doppler, and power Doppler sonography; MRI; and postmortem examination.
authors.affiliation: Department of Obstetrics, Charité, Campus Virchow, Klinikum Berlin, Augustenburger Platz 1, D-13353 Berlin, Germany.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Henrich
authors.forename: Ilka
authors.initials: I
authors.lastname: Fuchs
authors.forename: Christoph
authors.initials: C
authors.lastname: Bührer
authors.forename: Frank K H
authors.initials: FK
authors.lastname: van Landeghem
authors.forename: Matthias
authors.initials: M
authors.lastname: Albig
authors.forename: Brigitte
authors.initials: B
authors.lastname: Stoever
authors.forename: Joachim W
authors.initials: JW
authors.lastname: Dudenhausen
mesh_terms: D006332:Cardiomegaly / Q000000981:diagnostic imaging* / Q000209:etiology; D004453:Echoencephalography; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging*; D006801:Humans; D015160:Hydrops Fetalis / Q000000981:diagnostic imaging* / Q000209:etiology; D002538:Intracranial Arteriovenous Malformations / Q000150:complications / Q000000981:diagnostic imaging*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D016216:Ultrasonography, Prenatal