Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z), 11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity.
An asymmetric synthesis of 16-HETE, an endogenous inhibitor of neutrophil activity, was achieved in six steps from R-(-)-glycidyl benzyl ether in 28% overall yield.
Reddy
Y Krishna
YK
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9038, USA.
Reddy
L Manmohan
LM
Capdevila
Jorge H
JH
Falck
J R
JR
D002851:Chromatography, High Pressure Liquid; D006893:Hydroxyeicosatetraenoic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D009504:Neutrophils / Q000187:drug effects*; D013056:Spectrophotometry, Ultraviolet
C410424:16-hydroxy-5,8,11,14-eicosatetraenoic acid; D006893:Hydroxyeicosatetraenoic Acids; D007202:Indicators and Reagents