Efficient synthesis of 8-thiosubstituted guanine derivatives as potential tools for biochemical and biological studies.
A method for the selective introduction of the N2-(dimethylamino)methylene group into 8-thio-9-(2-hydroxyethoxymethyl)guanine (1) has been developed. The effect of the N2-amidine protection on the S-alkylation of 1 was studied.
Ikaunieks
Martins
M
Latvian Institute of Organic Synthesis, Riga, Latvia. ikaunieks@osi.lv
Madre
Marina
M
D000478:Alkylation; D001671:Biochemistry / Q000379:methods; D015195:Drug Design; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D013438:Sulfhydryl Compounds
D013438:Sulfhydryl Compounds; D006147:Guanine