[Platelets and arterial thrombosis].
The pathological mechanisms involved in arterial thrombus formation are similar to the mechanisms involved in physiological hemostasis. Arterial thrombosis is initiated following lesion of the vessel wall, either through rupture of an atherosclerotic plaque containing lipids, adhesive proteins and tissue factor or after angioplasty exposing the thrombogenic subendothelial matrix. Platelets play a major role in arterial thrombus formation through ADP secretion and thrombin generation on their activated surface. Arterial thrombosis is a frequent complication of atherosclerotic lesions and leads to acute ischemic events. These events are therapeutic emergencies which require administration of antithrombotic drugs inhibiting platelet functions and thrombin.
Cazenave
Jean-Pierre
JP
Etablissement Français du Sang-Alsace, INSERM U.311, BP 36, 10 rue Spielmann-67065 Strasbourg.
Gachet
Christian
C
Lanza
François
F
Wiesel
Marie-Louise
ML
D000244:Adenosine Diphosphate / Q000378:metabolism; D000800:Angioplasty, Balloon / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001157:Arterial Occlusive Diseases / Q000188:drug therapy* / Q000209:etiology*; D001161:Arteriosclerosis / Q000150:complications; D001241:Aspirin / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology*; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D013917:Thrombin / Q000096:biosynthesis; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology
D000900:Anti-Bacterial Agents; D005343:Fibrinolytic Agents; D010975:Platelet Aggregation Inhibitors; D000244:Adenosine Diphosphate; D013917:Thrombin; D001241:Aspirin