title: A transcriptional pause synchronizes translation with transcription in the tryptophanase operon leader region.
abstract: Regulation of transcription of the tryptophanase operon requires that translation of its leader peptide coding region, tnaC, be coupled with its transcription. We show in vitro that a transcription pause site exists at the end of the tnaC coding region and that translation of tnaC releases the paused transcription complex, coupling transcription with translation.
authors.affiliation: Department of Biological Sciences, Stanford University, Stanford, California 94305-5020, USA.
authors.forename: Feng
authors.initials: F
authors.lastname: Gong
authors.forename: Charles
authors.initials: C
authors.lastname: Yanofsky
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics; D001483:Base Sequence; D029968:Escherichia coli Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D009876:Operon; D014176:Protein Biosynthesis; D014158:Transcription, Genetic; D014368:Tryptophanase / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; C081473:tnaC protein, E coli; D014368:Tryptophanase