Minipig negative slow wave demonstrates target/nontarget differences in P300 paradigm.
The negative slow wave (NSW) is a late component of the event-related potential (ERP) in man modulated like the P300 by the stimulus, the task, and the response demand. Aiming at the development of a minipig model of schizophrenia, we investigated scalp ERPs in an auditory P300 paradigm in six Göttingen minipigs. Before training, we observed no difference between target and nontarget NSW. After training, target NSW amplitude was increased 50% compared to nontarget. A P350 was recognized, but the finding of a lack of target/nontarget difference is not conclusive.
Arnfred
Sidse Marie
SM
Department of Psychiatry, H:S Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark. s.arnfred@tdcadsl.dk
Lind
Nanna Marie
NM
Moustgaard
Anette
A
Hansen
Axel Kornerup
AK
Gjedde
Albert
A
D000161:Acoustic Stimulation; D000818:Animals; D004193:Discrimination Learning / Q000502:physiology; D004192:Discrimination, Psychological / Q000502:physiology; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology; D008297:Male; D013552:Swine; D013556:Swine, Miniature