title: 11q23-24 loss is associated with chromosomal instability in endometrial cancer.
abstract: A loss of the DNA copy number at chromosomal region 11q23-24 as detected by comparative genomic hybridization (CGH) is a marker of poor prognosis in patients with endometrial cancer. Malignant tumors display genetic instability, which is classified into two types: microsatellite instability (MIN) and chromosomal instability (CIN). In the present study, we examined whether there is a relation between loss of 11q23-24 and genetic instability in endometrial adenocarcinoma. Loss of 11q23-24 was detected in 4 of 70 endometrial cancers by fluorescence in situ hybridization (FISH), and DNA aneuploidy was detected by laser scanning cytometry (LSC) in 14 tumors. All tumors with 11q23-24 loss were aneuploid, and three of them were considered to have CIN. These findings suggest that 11q23-24 contains gene(s) necessary for normal chromosome replication and cell division.
authors.affiliation: Department of Obstetrics and Gynecology, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan. obgyn@yamaguchi-u.ac.jp
authors.forename: Keiko
authors.initials: K
authors.lastname: Kawasaki
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Suehiro
authors.forename: Kenji
authors.initials: K
authors.lastname: Umayahara
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Morioka
authors.forename: Takehisa
authors.initials: T
authors.lastname: Ito
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Saito
authors.forename: Naoki
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: Norihiro
authors.initials: N
authors.lastname: Sugino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kato
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D043171:Chromosomal Instability / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011003:Ploidies
chemical_list: D004273:DNA, Neoplasm