[Fatty acid composition of brain hemispheres of spontaneously hypertensive rats suckled by female Wistar rats].
Total lipid fatty acid composition was investigated in brain hemispheres of male Spontaneously Hypertensive Rats (SHR), compared with normotensive Wistar Kyoto rats (WKY) used as controls. Both strains were suckled by adoptive Wistar mothers, and then fed a standard diet after weaning. No difference was observed between the two hemispheres of WKY killed either at 10 or 30 days. In SHR killed at 10 days, the two hemispheres showed differences, SHR left hemispheres exhibiting greater fatty acid composition changes than those of WKY, phenomenon that toned down at 30 days. Hence, SHR pups showed a different total lipid fatty acid composition of their brain hemispheres when compared with their WKY controls, though the two strains received the same diet. Genetically programmed hypertension might be, directly or not, involved in these changes.
Savelli
Jean-Luc
JL
Faculté des sciences et techniques, université de Corse, Corté, France.
Narce
Michel
M
Fustier
Véronique
V
Poisson
Jean-Pierre
JP
D000375:Aging; D000818:Animals; D000833:Animals, Suckling; D001921:Brain / Q000254:growth & development; D001923:Brain Chemistry; D005227:Fatty Acids / Q000032:analysis*; D005260:Female; D051381:Rats; D011918:Rats, Inbred SHR / Q000502:physiology*; D011921:Rats, Inbred WKY; D017208:Rats, Wistar
D005227:Fatty Acids