Facilitation and disruption of memory for the passive avoidance task in the day-old chick using dopamine D1 receptor compounds.
This series of studies provides a behavioural account of dopamine D1-receptor-dependent facilitation and disruption of memory for the single-trial passive avoidance task in the day-old chick. The D1 antagonist, SCH23390, induced memory disruption in a dose-dependent manner from 60 min after training with a strong (100% methyl anthranilate) aversant experience. The D1 agonist, SKF38393, was found to facilitate memory in chicks given a weak (20% vol/vol methyl anthranilate) training experience. The D2 antagonist, sulpiride, and the D2 agonist, quinpirole, showed no memory effects. The research indicates an important role for dopamine D1-dependent mechanisms in memory formation in the chick.
Hale
M W
MW
School of Psychological Science, La Trobe University, Bundoora, Australia 3086.
Crowe
S F
SF
D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology*; D000367:Age Factors; D000818:Animals; D001070:Appetitive Behavior / Q000187:drug effects*; D001245:Association Learning / Q000187:drug effects*; D001362:Avoidance Learning / Q000187:drug effects*; D001552:Benzazepines / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D002645:Chickens; D004193:Discrimination Learning / Q000187:drug effects; D018491:Dopamine Agonists / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007279:Injections, Subcutaneous; D008570:Memory, Short-Term / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D019257:Quinpirole / Q000494:pharmacology; D017447:Receptors, Dopamine D1 / Q000187:drug effects*; D017448:Receptors, Dopamine D2 / Q000187:drug effects; D012153:Retention, Psychology / Q000187:drug effects; D013469:Sulpiride / Q000494:pharmacology; D013649:Taste / Q000187:drug effects
D001552:Benzazepines; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D019257:Quinpirole; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D013469:Sulpiride