Do disorders of movement cause movement disorders and dementia?
Neurons require long-distance microtubule-based transport systems to ferry vital cellular cargoes and signals between cell bodies and axonal or dendritic terminals. Considerable progress has been made on developing a molecular understanding of these processes and how they are integrated into normal neuronal functions. Recent work also suggests that these transport systems may fail early in the pathogenesis of a number of neurodegenerative diseases.
Goldstein
Lawrence S B
LS
Howard Hughes Medical Institute, Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA. lgoldstein@ucsd.edu
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D003704:Dementia / Q000150:complications* / Q000378:metabolism* / Q000523:psychology; D006801:Humans; D009069:Movement Disorders / Q000150:complications* / Q000378:metabolism* / Q000523:psychology; D015398:Signal Transduction / Q000502:physiology