Betaxolol attenuates retinal ischemia/reperfusion damage in the rat.
This study was performed to elucidate the protection afforded by post-treatment with Betoptic (0.25% betaxolol) against neuronal cell damage after ischemia/reperfusion insult in rats. Betaxolol was applied topically after the start of reperfusion and its effect was evaluated by morphometry and choline acetyltransferase immunoreactivity of retinas at 7 days after reperfusion. In non-treated eyes, the thickness of the inner plexiform layer decreased markedly after a reperfusion period of both 3 and 7 days. However, when eyes were treated with betaxolol after ischemia/reperfusion injury, both the reduction of the inner plexiform layer thickness and the retinal choline acetyltransferase immunoreactivity were significantly attenuated. These findings suggest that betaxolol is an efficient neuroprotective agent and prevents the retinal cell damage induced by ischemic injury in rats.
Cheon
Eun Woo
EW
Department of Anatomy and Neurobiology, Health Science Institute, Gyeongsang National University, Chinju, South Korea.
Park
Chang Hwan
CH
Kang
Sang Soo
SS
Cho
Gyeong Jae
GJ
Yoo
Ji Myong
JM
Song
Joon Kyung
JK
Choi
Wan Sung
WS
D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D015784:Betaxolol / Q000008:administration & dosage / Q000627:therapeutic use*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D007150:Immunohistochemistry; D007429:Intraocular Pressure / Q000187:drug effects / Q000502:physiology; D008297:Male; D018696:Neuroprotective Agents; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000473:pathology; D012160:Retina / Q000201:enzymology / Q000473:pathology*; D012162:Retinal Degeneration / Q000473:pathology / Q000517:prevention & control
D000319:Adrenergic beta-Antagonists; D018696:Neuroprotective Agents; D002795:Choline O-Acetyltransferase; D015784:Betaxolol