[Evaluation of the local neurotoxicity of lidocaine following epidural administration].
The morphological and histoenzymological changes in spinal neuron and in the spinal ganglia of outbred dogs were analyzed in the epidural administration of 2% solution of lydocaine. The results showed a lack of pathological or structural-and-metabolic changes in the nervous tissue. The morpho-functional reshaping occurring in the spinal cord cells and in the spinal ganglia was in line with that when the 0.9% solution of sodium chloride was in use. The registered changes ranging within the physiological deviations' limits witnessed to a functional reaction of the studied nervous-tissue structures to epidural drugs' injections.
Tomson
V V
VV
Volchkov
V A
VA
Boĭkova
N V
NV
Strashnov
V I
VI
Zaĭtsev
A A
AA
D000779:Anesthetics, Local / Q000633:toxicity*; D000818:Animals; D004285:Dogs; D005727:Ganglia, Spinal / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D007268:Injections, Epidural; D008012:Lidocaine / Q000633:toxicity*; D008854:Microscopy, Electron; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D010084:Oxidation-Reduction; D013116:Spinal Cord / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure
D000779:Anesthetics, Local; D008012:Lidocaine