title: Exercise-induced human coronary collateral function: quantitative assessment during acute coronary occlusions.
abstract: In 50 patients undergoing percutaneous transluminal coronary angioplasty because of chronic angina pectoris, a collateral flow index (CFI) was determined at the start and the end of two 1-min coronary occlusions, randomly accompanied by a resting state or a 3-min dynamic handgrip exercise (DHE). CFI expressing collateral flow relative to normal antegrade flow was determined by simultaneous coronary occlusive pressure, mean aortic pressure and central venous pressure measurements. When comparing CFI without and with DHE at the start as well as at the end of balloon occlusions, a significant increase was observed with DHE (overall p < 0.0001); start: 0.18 +/- 0.12 vs. 0.22 +/- 0.13, respectively (p = 0.01); end of occlusion: 0.21 +/- 0.14 vs. 0.25 +/- 0.14, respectively (p = 0.007).
authors.affiliation: Swiss Cardiovascular Center Bern, University Hospital, CH-3010 Bern, Switzerland.
authors.forename: Tilmann
authors.initials: T
authors.lastname: Pohl
authors.forename: Kerstin
authors.initials: K
authors.lastname: Wustmann
authors.forename: Stephan
authors.initials: S
authors.lastname: Zbinden
authors.forename: Stephan
authors.initials: S
authors.lastname: Windecker
authors.forename: Haresh
authors.initials: H
authors.lastname: Mehta
authors.forename: Bernhard
authors.initials: B
authors.lastname: Meier
authors.forename: Christian
authors.initials: C
authors.lastname: Seiler
mesh_terms: D000208:Acute Disease; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D002496:Central Venous Pressure / Q000187:drug effects / Q000502:physiology; D003097:Collateral Circulation / Q000187:drug effects / Q000502:physiology*; D003326:Coronary Circulation / Q000187:drug effects / Q000502:physiology*; D003327:Coronary Disease / Q000503:physiopathology / Q000628:therapy; D003331:Coronary Vessels / Q000187:drug effects / Q000503:physiopathology* / Q000601:surgery; D004562:Electrocardiography; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013223:Statistics as Topic; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists