Role of nitric oxide and lipid peroxidation in pathophysiological mechanisms of audiogenic seizures in GEP Rats and DBA/2 mice.
We evaluated the role of nitric oxide and lipid peroxidation in the pathophysiological mechanisms of seizures in genetically epilepsy prone (GEP) rats and DBA/2 mice with genetically determined audiogenic epilepsy. In rats and mice acoustic stimulation led to locomotor activation followed by clonic-tonic seizures. The contents of nitric oxide and lipid peroxidation products at the peak of seizures markedly surpassed the control level.
Bashkatova
V G
VG
Laboratory of Neurochemical Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow. vata@rinet.ru
Mikoyan
V D
VD
Malikova
L A
LA
Raevskii
K S
KS
D000818:Animals; D004195:Disease Models, Animal; D020195:Epilepsy, Reflex / Q000235:genetics / Q000503:physiopathology*; D005971:Glutamates / Q000378:metabolism; D015227:Lipid Peroxidation; D051379:Mice; D008811:Mice, Inbred DBA; D008962:Models, Theoretical; D009569:Nitric Oxide / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures
D005971:Glutamates; D009569:Nitric Oxide