Synthesis of carbocyclic analogues of thymidine.
A new route towards an enantiomerically pure carbocyclic 2'-deoxyribonucleoside precursor was developed. After coupling with a nucleobase the product is easily accessible for further modifications at the 3'-hydroxy group.
Ludek
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OR
Institute of Organic Chemistry, University of Hamburg, Hamburg, Germany.
Meier
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D003853:Deoxyribonucleosides / Q000737:chemistry*; D006900:Hydroxylation; D009712:Nucleotides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D013936:Thymidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
D003853:Deoxyribonucleosides; D009712:Nucleotides, Cyclic; D018894:Reverse Transcriptase Inhibitors; D013936:Thymidine