Labeled citrate metabolism in bone fractures and impaired innervation.
Changes in (14)C incorporation into regenerate after bone fracture and impairment of mandibular innervation, and injection of [3-(14)C]cytrate corresponded to the stages of reparative osteogenesis: after 1 week (14)C incorporation in the cellular-fibrous callus surpassed its release, after 2 weeks the rates of (14)C incorporation and release in the chondroid callus become similar, and after 4 weeks the release of the label predominated in the primary bone callus. Denervation reduced (14)C incorporation into regenerate, which impaired bone remodeling. Citrate in the bones is characterized by high metabolic activity.
Petrovich
Yu A
YA
Moscow State Medical Stomatological University.
Podorozhnaya
R P
RP
Kichenko
S M
SM
Dmitriev
I M
IM
D000818:Animals; D001842:Bone and Bones / Q000294:innervation* / Q000378:metabolism*; D002244:Carbon / Q000378:metabolism; D002951:Citrates / Q000378:metabolism*; D005269:Femur / Q000294:innervation / Q000378:metabolism / Q000473:pathology; D050723:Fractures, Bone; D008334:Mandible / Q000294:innervation; D008956:Models, Chemical; D010012:Osteogenesis; D051381:Rats; D013997:Time Factors
D002951:Citrates; D002244:Carbon