title: Conjugates of oligo(2'-O-methylribonucleotides) with minor groove binders as new sequence-specific agents recognizing both grooves of double-stranded DNA.
abstract: Design, synthesis and physico-chemical studies of new pyrimidine oligo(2'-O-methylribonucleotide) conjugates with one or two oligo(pyrrolecarboxamide) minor groove binders (MGB) are described.
authors.affiliation: Novosibirsk Institute of Bioorganic Chemistry SB RAS, Novosibirsk, Russia. dasha@ngs.ru
authors.forename: D
authors.initials: D
authors.lastname: Novopashina
authors.forename: A
authors.initials: A
authors.lastname: Sinyakov
authors.forename: V
authors.initials: V
authors.lastname: Ryabinin
authors.forename: A
authors.initials: A
authors.lastname: Venyaminova
authors.forename: A
authors.initials: A
authors.lastname: Boutorine
mesh_terms: D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D007202:Indicators and Reagents; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D009843:Oligoribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D011743:Pyrimidines
chemical_list: D007202:Indicators and Reagents; D009843:Oligoribonucleotides; D011743:Pyrimidines; D004247:DNA