title: Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction.
abstract: OBJECTIVE
  To explore the frequency and significance of ApoE gene polymorphisms in Chinese patients with atherosclerotic cerebral infarction (ACI).
  
  
  METHODS
  Polymerase chain reaction and gene sequencing, single nucleotide polymorphisms of ApoE gene were used to analyze 33 cases of patients with ACI and 35 controls.
  
  
  RESULTS
  The frequencies of ApoE gene single nucleotide polymorphisms 465C/G, 462C/G and 451delC in the ACI group were significantly higher than those in the control group (P<0.05). The prevalence of polymorphism 486G/T in the control group was significantly higher than that in the ACI group (P=0.011).
  
  
  CONCLUSIONS
  465C/G,462C/G and 451delC polymorphisms might be associated with ACI.486GT allele might have protective effect on the pathogenesis of ACI.
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, China. lobenyan@263.net
authors.forename: Ben-yan
authors.initials: BY
authors.lastname: Luo
authors.forename: Zhi
authors.initials: Z
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Pan
mesh_terms: D000368:Aged; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods
chemical_list: D001057:Apolipoproteins E