title: Prospective study of high-dose chemotherapy and autologous peripheral stem cell transplantation in adult patients with advanced desmoplastic small round-cell tumour.
abstract: A total of 10 desmoplastic small round-cell tumour patients were treated by high-dose chemotherapy with stem cell support. After high-dose chemotherapy, no complete response conversion was obtained and EWS-WT1 fusion transcript detection was positive in the peripheral blood during follow-up in all patients. High-dose chemotherapy did not seem to change the results in desmoplastic small round-cell tumour.
authors.affiliation: Department of Medical Oncology and Hematology, Istituto Clinico Humanitas, Via Manzoni 56, Rozzano, Milan 20089, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bertuzzi
authors.forename: L
authors.initials: L
authors.lastname: Castagna
authors.forename: V
authors.initials: V
authors.lastname: Quagliuolo
authors.forename: V
authors.initials: V
authors.lastname: Ginanni
authors.forename: S
authors.initials: S
authors.lastname: Compasso
authors.forename: M
authors.initials: M
authors.lastname: Magagnoli
authors.forename: M
authors.initials: M
authors.lastname: Balzarotti
authors.forename: A
authors.initials: A
authors.lastname: Nozza
authors.forename: L
authors.initials: L
authors.lastname: Siracusano
authors.forename: I
authors.initials: I
authors.lastname: Timofeeva
authors.forename: B
authors.initials: B
authors.lastname: Sarina
authors.forename: H Soto
authors.initials: HS
authors.lastname: Parra
authors.forename: A
authors.initials: A
authors.lastname: Santoro
mesh_terms: D000008:Abdominal Neoplasms / Q000235:genetics / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D018288:Carcinoma, Small Cell / Q000235:genetics / Q000628:therapy*; D003131:Combined Modality Therapy; D017931:DNA Primers / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000378:metabolism; D036102:Peripheral Blood Stem Cell Transplantation; D011379:Prognosis; D011446:Prospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015996:Survival Rate; D014182:Transplantation, Autologous; D016896:Treatment Outcome
chemical_list: D017931:DNA Primers; C106032:EWS1-WT1 fusion protein, human; D015514:Oncogene Proteins, Fusion