Efficacy and durability of nevirapine in antiretroviral-experienced patients.
The non-nucleoside reverse transcriptase inhibitor (NNRTI) nevirapine (NVP) has been used as a component of salvage therapy for patients who have experienced virologic failure while taking nucleosides and protease inhibitors (PIs). In spite of broad cross-resistance within the NNRTI class, NVP may also play a role in salvage therapy for patients who have experienced failure while taking NNRTIs Another role for NVP in treatment-experienced patients is in so-called "PI switch" strategies, in which NVP is substituted for a PI within a virologically successful combination regimen. This paper reviews the clinical data that support the use of NVP in salvage regimens and PI switch strategies.
Harris
Marianne
M
B. C Centre for Excellence in HIV/AIDS and the Canadian HIV Trials Network, St Paul's Hospital, Providence Health Care, University of British Columbia, 1081 Burrard Street, Vancouver, V6Z 1Y6, Canada. mharris@hivnet.ubc.ca
D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D019829:Nevirapine / Q000627:therapeutic use*; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D016879:Salvage Therapy
D018894:Reverse Transcriptase Inhibitors; D019829:Nevirapine