[Therapeutic safety of antimycotics in the treatment of systemic fungal infections].
The authors summarize the most important data of antimycotics used in the praxis. The indications of these drugs as well as the absorption, the antimycotic mechanism, the side-effects and drug-interactions of antifungal agents are discussed. The pathomechanism of amphotericin B, flucytosine, fluconasole, ketoconasole, itraconasole and the possibilities of their clinical administrations, further their side-effects and interactions are demonstrated in details. The most beneficial characteristics and more important interactions of these drugs are shown in tables for easier application in the everyday therapy.
Fehér
János
J
Semmelweis Egyetem, Altalános Orvostudományi Kar, II. Belklinika, Budapest. feher@bel2.sote.hu
Lengyel
Gabriella
G
D000666:Amphotericin B / Q000009:adverse effects; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004347:Drug Interactions; D015725:Fluconazole / Q000009:adverse effects; D005437:Flucytosine / Q000009:adverse effects; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects; D007654:Ketoconazole / Q000009:adverse effects; D008099:Liver / Q000187:drug effects; D009181:Mycoses / Q000188:drug therapy*
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine; D007654:Ketoconazole