Treatment of polymorphic light eruption.
Polymorphic light eruption (PLE) is a highly prevalent photosensitivity disorder, estimated to affect 11-21% people in temperate countries. Typically, PLE appears as a recurrent pruritic eruption comprising papules and/or vesicles and/or plaques, which occurs on photo-exposed skin sites following sun exposure, and which heals without scarring. Commoner in females, the aetiology is uncertain, although there is evidence of an immune basis. We perform a review of the prophylaxis and treatment of this condition. While sun protection, corticosteroids and desensitization phototherapy are the mainstays of management, a range of anti-inflammatory and immunomodulatory agents are reported.
Ling
Tsui C
TC
Photobiology Unit, Dermatology Centre, University of Manchester, Hope Hospital, Manchester, UK.
Gibbs
Neil K
NK
Rhodes
Lesley E
LE
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D010778:Photochemotherapy; D010787:Photosensitivity Disorders / Q000517:prevention & control / Q000628:therapy*; D010789:Phototherapy; D011322:Primary Prevention; D013472:Sunlight / Q000009:adverse effects*; D013473:Sunscreening Agents / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D013473:Sunscreening Agents