title: [The remyelination phenomenon in multiple sclerosis].
abstract: Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system. Available treatments (immuno-modulators, immuno-suppressants) limit central nervous system inflammation and are only partially effective. Remyelination of naked axons becomes insufficient in most cases as the disease progresses. The reason for this repair deficit are many, including oligodendroglial, axonal and environmental factors. Understanding why remyelination fails is crucial for devising effective methods by which to enhance it.
authors.affiliation: Fédération de Neurologie et INSERM U-495, Groupe Hospitalier Pitié-Salpêtrière-47-83, Boulevard de l'Hôpital-75651 Paris.
authors.forename: Catherine
authors.initials: C
authors.lastname: Lubetzki
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000502:physiology; D001369:Axons / Q000648:ultrastructure; D004195:Disease Models, Animal; D006133:Growth Substances / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D008264:Macrophages / Q000502:physiology; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000503:physiopathology*; D009186:Myelin Sheath / Q000502:physiology*; D009836:Oligodendroglia / Q000502:physiology
chemical_list: D006133:Growth Substances