Drug correction of behavioral reactions and metabolic disorders in rats with craniocerebral trauma.
Intraperitoneal injection of bemithyl in a dose of 25 mg/kg for 3 days after craniocerebral injury reduced psychopathological symptoms in rats with different resistance to acute hypoxia, restored the structure of individual behavior, and prevented metabolic disorders in the brain.
Zarubina
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Department of Pharmacology, Military Medical Academy, Ministry of Defense of the Russian Federation, St. Petersburg.
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D001562:Benzimidazoles / Q000494:pharmacology*; D001835:Body Weight; D001921:Brain / Q000187:drug effects; D001930:Brain Injuries / Q000188:drug therapy; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control; D006259:Craniocerebral Trauma / Q000188:drug therapy*; D004195:Disease Models, Animal; D000860:Hypoxia / Q000188:drug therapy; D007274:Injections, Intraperitoneal; D008297:Male; D008659:Metabolic Diseases / Q000517:prevention & control; D018696:Neuroprotective Agents / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D051381:Rats; D013696:Temperature; D013997:Time Factors
D000975:Antioxidants; D001562:Benzimidazoles; D018696:Neuroprotective Agents; C049825:bemethyl; D010889:Piracetam