title: A PRESTO-SENSE sequence with alternating partial-Fourier encoding for rapid susceptibility-weighted 3D MRI time series.
abstract: A 3D sequence for dynamic susceptibility imaging is proposed which combines echo-shifting principles (such as PRESTO), sensitivity encoding (SENSE), and partial-Fourier acquisition. The method uses a moderate SENSE factor of 2 and takes advantage of an alternating partial k-space acquisition in the "slow" phase encode direction allowing an iterative reconstruction using high-resolution phase estimates. Offering an isotropic spatial resolution of 4 x 4 x 4 mm(3), the novel sequence covers the whole brain including parts of the cerebellum in 0.5 sec. Its temporal signal stability is comparable to that of a full-Fourier, full-FOV EPI sequence having the same dynamic scan time but much less brain coverage. Initial functional MRI experiments showed consistent activation in the motor cortex with an average signal change slightly less than that of EPI.
authors.affiliation: Imagerie Moléculaire et Fonctionelle: de la Physiologie à la Thérapie, ERT CNRS/Université Victor Segalen Bordeaux 2, Bordeaux, France.
authors.forename: Markus
authors.initials: M
authors.lastname: Klarhöfer
authors.forename: Bixente
authors.initials: B
authors.lastname: Dilharreguy
authors.forename: Peter
authors.initials: P
authors.lastname: van Gelderen
authors.forename: Chrit T W
authors.initials: CT
authors.lastname: Moonen
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology*; D005583:Fourier Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D013997:Time Factors