title: Octreotide in control of multiple liver metastases from gastrinoma.
abstract: The somatostatin analogue octreotide was effective in controlling systemic effects related to multiple liver metastases from a gastrinoma. A 61-year-old man underwent distal gastrectomy for gastrinoma in the duodenum, because a curative resection was not feasible due to metastases found in paraaortic lymph nodes during operation. Multiple liver metastases, associated with an increase in serum gastrin concentration, were found by magnetic resonance imaging 16 months after the operation. Although chemotherapy with dimethyltrizenoimidazole carboxamide was not effective, subcutaneous administration of octreotide was effective in controlling the growth of the liver metastases and in stabilizing serum gastrin. The patient now receives subcutaneous injections of octreotide, at 200 microg a day, twice a week, as an outpatient.
authors.affiliation: Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
authors.forename: Fumito
authors.initials: F
authors.lastname: Saijo
authors.forename: Hiroo
authors.initials: H
authors.lastname: Naito
authors.forename: Yuji
authors.initials: Y
authors.lastname: Funayama
authors.forename: Kouhei
authors.initials: K
authors.lastname: Fukushima
authors.forename: Chikashi
authors.initials: C
authors.lastname: Shibata
authors.forename: Akihiko
authors.initials: A
authors.lastname: Hashimoto
authors.forename: Taku
authors.initials: T
authors.lastname: Kitayama
authors.forename: Munenori
authors.initials: M
authors.lastname: Nagao
authors.forename: Seiki
authors.initials: S
authors.lastname: Matsuno
authors.forename: Iwao
authors.initials: I
authors.lastname: Sasaki
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D015408:Gastrinoma / Q000188:drug therapy* / Q000556:secondary; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000473:pathology*; D015043:Zollinger-Ellison Syndrome / Q000150:complications
chemical_list: D018931:Antineoplastic Agents, Hormonal; D015282:Octreotide