Non-inhibition of acetylcholinesterase by cycloSal nucleotides.
An acetylcholinesterase (AChE) assay based on the Rappaport method was established to investigate the behaviour of several cycloSal nucleotides against AChE from electrophorus electricus and human sources (purified enzymes). AChE is a physiologically essential enzyme as it catalyzes the hydrolysis of the neurotransmitter acetylcholine. No inhibition was observed in any of the cases.
Ducho
C
C
Institute of Organic Chemistry, University of Hamburg, Hamburg, Germany.
Balzarini
J
J
Meier
C
C
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D004593:Electrophorus; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D009711:Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; D009711:Nucleotides; D000110:Acetylcholinesterase