title: Early functional recovery and the fate of the diffusion/perfusion mismatch in patients with proximal middle cerebral artery occlusion.
abstract: BACKGROUND
  The relationship between early neurological recovery, time to recanalization and the salvage of hypoperfused, but not diffusion-restricted tissue was investigated.
  
  
  METHODS
  In 17 patients with acute middle cerebral artery occlusion, a multiparametric stroke MRI protocol was performed < 6 h after symptom onset, as well as at day 2 and 7. Recanalization was monitored with transcranial Doppler or with conventional angiography (during local thrombolysis). Functional improvement was defined as a change of > or = 4 points on the National Institutes of Health Stroke Scale score.
  
  
  RESULTS
  In patients with functional improvement, 78% (median, range 66-95%) of the acute mean transit time (MTT) lesion escaped infarction compared with 28% (median, range -13 to 78%) in patients without neurological improvement (p < 0.01). Similarly, the percentage of tissue with a time-to-peak (TTP) delay of > or = 2 s not progressing to infarction was 80 and 4% in the groups with and without improvement, respectively (p < 0.01). Neurological improvement was more frequent in patients with early (< or = 3 h after presentation) recanalization, due to the salvage of larger areas of initially hypoperfused tissue.
  
  
  CONCLUSIONS
  The salvage of hypoperfused tissue is a major factor influencing early neurological improvement.
authors.affiliation: Department of Neurology, J.W. Goethe University Frankfurt am Main, Germany.
authors.forename: Oliver C
authors.initials: OC
authors.lastname: Singer
authors.forename: Richard
authors.initials: R
authors.lastname: Du Mesnil De Rochemont
authors.forename: Christian
authors.initials: C
authors.lastname: Foerch
authors.forename: Astrid
authors.initials: A
authors.lastname: Stengel
authors.forename: Matthias
authors.initials: M
authors.lastname: Sitzer
authors.forename: Heiner
authors.initials: H
authors.lastname: Lanfermann
authors.forename: Tobias
authors.initials: T
authors.lastname: Neumann-Haefelin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002560:Cerebrovascular Circulation / Q000502:physiology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000175:diagnosis* / Q000503:physiopathology* / Q000628:therapy; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D020127:Recovery of Function / Q000502:physiology; D015912:Thrombolytic Therapy; D013997:Time Factors