title: Microwave-assisted polymer-supported combinatorial synthesis.
abstract: Lead identification and optimization is always a challenge to the medicinal chemists in drug discovery. Numbers of simple to complex and smaller to bigger organic compounds are prepared to meet the screening purpose of biological targets. Conventional solution phase synthetic methodologies are lacking the speed to run along with the need of medicinally interesting compounds due to their long reaction time, tedious work-up and purification problems. Alternatively opted polymer-supported synthesis of combinatorial libraries has been emerged as a promising tool in generating large numbers of structurally diverse molecules in a manner rapid and parallel. Microwave-assisted solid/liquid phase combinatorial synthetic techniques have been proved efficient in reducing the reaction time from days & hours to minutes & seconds and more promisingly to produce improved yields with high purities. This review briefs about the theory behind microwave chemical technology and glimpses of recent advancements in its application on polymer supported combinatorial synthesis.
authors.affiliation: Laboratory of Combinatorial Drug Discovery, Department of Chemistry, National Dong Hwa University, Shou-Feng, Hualien 974, Taiwan.
authors.forename: K M K
authors.initials: KM
authors.lastname: Swamy
authors.forename: Wen-Ben
authors.initials: WB
authors.lastname: Yeh
authors.forename: Mei-Jung
authors.initials: MJ
authors.lastname: Lin
authors.forename: Chung-Ming
authors.initials: CM
authors.lastname: Sun
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D006361:Heating; D008872:Microwaves; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
chemical_list: D011108:Polymers; D012997:Solvents