title: A case of hypereosinophilic cardiomyopathy: additional value of the myocardial contrast agent SonoVue for the differential diagnosis of a cardiac mass.
abstract: We describe the case of a 37-year-old male referred because of hypereosinophilia associated with dyspnea. Transthoracic harmonic echocardiography showed an extensive myocardial infiltration and highlighted an intraventricular "in plus" image, whose characteristics were compatible with a diagnosis of intracardiac thrombus. The use of the myocardial contrast agent SonoVue (1 ml in bolus i.v. and 4 ml at an infusion velocity of 2 ml/min) allowed us to immediately identify, during left ventricular chamber opacification, the exact endocardial border of the left ventricular cavity and, later (when the residual SonoVue was evident only at the level of the myocardial walls), the true characteristics of the "in plus" image. This approach revealed the infiltration of the myocardial tissue and of both papillary muscles and chordae tendinae. The use of the myocardial contrast agent SonoVue may be, therefore, useful to distinguish the origin of "in plus" images often evident at echocardiography in the hypereosinophilic syndrome.
authors.affiliation: Division of Cardioangiology-ICCU, Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy.
authors.forename: Arcangelo
authors.initials: A
authors.lastname: D'Errico
authors.forename: Maurizio
authors.initials: M
authors.lastname: Galderisi
authors.forename: Giuditta
authors.initials: G
authors.lastname: Pollio
authors.forename: Lucio
authors.initials: L
authors.lastname: Catalano
authors.forename: Bruno
authors.initials: B
authors.lastname: Rotoli
authors.forename: Oreste
authors.initials: O
authors.lastname: de Divitiis
mesh_terms: D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging*; D003287:Contrast Media; D003937:Diagnosis, Differential; D015150:Echocardiography, Doppler / Q000379:methods; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000000981:diagnostic imaging*; D008297:Male; D010743:Phospholipids; D013459:Sulfur Hexafluoride; D013927:Thrombosis / Q000000981:diagnostic imaging
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride