title: Dosimetry of radioiodine for embryo and fetus.
abstract: This paper discusses the biokinetic and dosimetric models adopted in ICRP Publication 88 for the evaluation of fetal doses resulting from maternal intakes of radioiodine. The biokinetic model is used to simulate the behaviour of iodine in both the mother and the fetus. Such simulations provide the basis for the estimation of the dose to the embryo and determine the distribution of maternal iodine at the beginning of the fetal period. The model considers iodine to accumulate in the fetal thyroid from the 11th week. The dose to the fetus delivered following birth is evaluated with the biokinetic and dosimetric models described in ICRP Publication 67. Although a substantial fraction of the emitted energy of electrons and photons is less than 10 keV, conventionally assumed to be non-penetrating radiation, these emissions can escape the small fetal thyroid. Absorbed fractions for both self-dose and crossfire were evaluated for the requirements of radioiodine dosimetry in ICRP Publication 88.
authors.affiliation: Radiation Protection Institute, Melnikova 53, Kiev-050, Ukraine. vberkov@visti.com
authors.forename: V
authors.initials: V
authors.lastname: Berkovski
authors.forename: K F
authors.initials: KF
authors.lastname: Eckerman
authors.forename: A W
authors.initials: AW
authors.lastname: Phipps
authors.forename: D
authors.initials: D
authors.lastname: Nosske
mesh_terms: D000284:Administration, Oral; D003198:Computer Simulation; D005260:Female; D005865:Gestational Age; D006801:Humans; D007457:Iodine Radioisotopes / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D008954:Models, Biological; D011247:Pregnancy; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods* / Q000592:standards; D018570:Risk Assessment / Q000379:methods; D013961:Thyroid Gland / Q000196:embryology* / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D007457:Iodine Radioisotopes