title: A new approach for assessing early osteoarthritis in the rat.
abstract: Several animal models have been developed to investigate osteoarthritis and potential disease-modifying therapeutics. However, early disease data from these models are limited by the resolution of current imaging modalities. In this in-vitro study, an optical coherence tomography (OCT) system with an axial resolution of 15 micro m was used to track sequential changes in osteoarthritic rat knees. Osteoarthritis was induced via transection of the medial collateral ligament and an artificial full thickness meniscal tear. Imaging occurred at one, two, and three weeks after surgery. OCT successfully detected early signs of osteoarthritic change, including alteration of the cartilage surface and disruption of the bone-cartilage interface. This study demonstrates that OCT, along with the induction of mechanical injury, provides an excellent model for monitoring the sequential changes of osteoarthritis.
authors.affiliation: Orthopedics Research, Department of Orthopedic Surgery, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA, 02115, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Roberts
authors.forename: S B
authors.initials: SB
authors.lastname: Adams
authors.forename: N A
authors.initials: NA
authors.lastname: Patel
authors.forename: D L
authors.initials: DL
authors.lastname: Stamper
authors.forename: M S
authors.initials: MS
authors.lastname: Westmore
authors.forename: S D
authors.initials: SD
authors.lastname: Martin
authors.forename: J G
authors.initials: JG
authors.lastname: Fujimoto
authors.forename: M E
authors.initials: ME
authors.lastname: Brezinski
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000737:chemistry; D004195:Disease Models, Animal; D008297:Male; D010003:Osteoarthritis / Q000175:diagnosis*; D051381:Rats; D011917:Rats, Inbred Lew; D013997:Time Factors; D014054:Tomography / Q000379:methods*