title: Association of newer diastolic function parameters with age in healthy subjects: a population-based study.
abstract: OBJECTIVE
  We sought to determine if newer Doppler diastolic function parameters are associated with age and to define age-stratified reference ranges for these parameters in a population-based setting.
  
  
  BACKGROUND
  Although newer Doppler parameters aid in the evaluation of diastolic function and filling pressures, age-specific reference ranges are poorly described.
  
  
  METHODS
  Randomly selected residents of Olmsted County, Minn, age >/= 45 years were studied (n = 2042) prospectively. Those without a history of cardiovascular disease or abnormal 2-dimensional echocardiograms were selected. Measured parameters included the transmitral early (E) and late (A) filling velocities at rest and with Valsalva, A duration, pulmonary venous atrial reversal duration, lateral and septal early diastolic mitral annular velocities, E/lateral early diastolic mitral annular velocity, E/septal early diastolic mitral annular velocity, and the index of left ventricular myocardial performance.
  
  
  RESULTS
  A total of 1012 subjects met the inclusion criteria. Both A duration (r = 0.18, P <.001) and pulmonary venous atrial reversal duration (r = 0.28, P <.001) were longer in older subjects, whereas their difference showed a marginal correlation with age (r = 0.07, P =.036). The E/A ratio at peak Valsalva correlated with age (r = -0.54, P <.001) whereas the change in E/A with Valsalva (corrected for E-A fusion) showed a marginal correlation with age (r = 0.08, P =.032). Both E/lateral early diastolic mitral annular velocity (r = 0.39, P <.001) and E/septal early diastolic mitral annular velocity (r = 0.27, P <.001) increased with age. Left ventricular myocardial performance showed a marginal correlation with age (r = 0.08, P =.014). Age specific reference ranges (median, 5th and 95th percentiles) for all parameters are provided.
  
  
  CONCLUSIONS
  All newer Doppler diastolic function parameters showed a variable but significant correlation with age. Age-specific reference values will aid in the interpretation of diastolic function parameters.
authors.affiliation: Department of Health Science Research, Mayo Clinic and Foundation, Rochester, Minnesota, USA.
authors.forename: Vijaya K
authors.initials: VK
authors.lastname: Munagala
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Jacobsen
authors.forename: Douglas W
authors.initials: DW
authors.lastname: Mahoney
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Rodeheffer
authors.forename: Kent R
authors.initials: KR
authors.lastname: Bailey
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Redfield
mesh_terms: D000367:Age Factors; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D003430:Cross-Sectional Studies; D003971:Diastole / Q000502:physiology; D015150:Echocardiography, Doppler; D005240:Feasibility Studies; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D008910:Minnesota; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000502:physiology; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012016:Reference Values; D012737:Sex Factors; D013223:Statistics as Topic; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology; D014636:Valsalva Maneuver; D016276:Ventricular Function; D016277:Ventricular Function, Left / Q000502:physiology*