Increased thirst and vasopressin secretion after myocardial infarction in rats.
Impaired regulation of salt and water balance in left ventricular dysfunction and heart failure can lead to pulmonary and peripheral edema and hyponatremia. Previous studies of disordered water regulation in heart failure have used models of low cardiac output with normal cardiac function (e.g., inferior vena cava ligation). We investigated thirst and vasopressin (AVP) secretion in a rat myocardial infarction model of chronic left ventricular dysfunction/heart failure in response to a 24-h water deprivation period. Thirst (implied from water drunk), hematocrit, plasma renin activity, and plasma AVP concentrations increased with water deprivation vs. ad libitum water access. Thirst and plasma AVP concentrations were significantly positively correlated with infarct size after 24-h water deprivation but not under ad libitum water access conditions. The mechanism by which this occurs is unclear but could involve increased osmoreceptor sensitivity, altered stimulation of baroreceptors, the renin-angiotensin system, or altered central neural control.
De Smet
H R
HR
Dept. of Medicine, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia.
Menadue
M F
MF
Oliver
J R
JR
Phillips
P A
PA
D000818:Animals; D001835:Body Weight; D004195:Disease Models, Animal; D006333:Heart Failure / Q000097:blood / Q000473:pathology / Q000503:physiopathology; D009203:Myocardial Infarction / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D013894:Thirst / Q000502:physiology*; D014667:Vasopressins / Q000097:blood / Q000378:metabolism*; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000473:pathology / Q000503:physiopathology; D014868:Water Deprivation / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000502:physiology
D014667:Vasopressins