Towards a circular bis-peptide nucleic acid.
En route to a circular bis-PNA molecule, we have synthesized and characterized the DNA binding of several "clamp"-type bis-PNAs. In order to incorporate charge into a circular PNA, a new linker based on the achiral 2-aminoethylglycine has been used.
Hudson
R H E
RH
Department of Chemistry, The University of Western Ontario, London, Ontario, Canada. rhhudson@uwo.ca
Tse
J
J
D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000737:chemistry; D007202:Indicators and Reagents; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D020135:Peptide Nucleic Acids; D010456:Peptides, Cyclic; D004247:DNA