title: Role of oxygen free radicals in patients with acute pancreatitis.
abstract: OBJECTIVE
  The generation of oxygen free radicals has been implicated in the pathogenesis of experimental pancreatitis. The aim of this study was to determine the role of oxygen free radicals in patients with acute pancreatitis.
  
  
  METHODS
  The plasma levels of C-reactive protein (CRP), lipid peroxide (LPO), myeloperoxidase (MPO) and superoxide dismutase (SOD) were measured in 13 patients with acute pancreatitis and 14 healthy volunteers.
  
  
  RESULTS
  Among the patients with acute pancreatitis, there were higher plasma levels of LPO and MPO and lower SOD activity in patients with severe pancreatitis than in those with mild pancreatitis. However, there was no significant difference in the serum marker of oxidative stress no matter what the etiology was. The LPO level was especially correlated with the concentration of serum CRP and CT severity index.
  
  
  CONCLUSIONS
  The oxygen free radicals may be closely associated with inflammatory process and the severity of acute pancreatitis. Especially, the concentration of plasma LPO is a meaningful index for determining the severity of the disease.
authors.affiliation: Department of Internal Medicine, Institute of Gastroenterology, College of Medicine, Yonsei University, Seoul, 120-752 Korea.
authors.forename: Byung Kyu
authors.initials: BK
authors.lastname: Park
authors.forename: Jae Bock
authors.initials: JB
authors.lastname: Chung
authors.forename: Jin Heon
authors.initials: JH
authors.lastname: Lee
authors.forename: Jeong Hun
authors.initials: JH
authors.lastname: Suh
authors.forename: Seung Woo
authors.initials: SW
authors.lastname: Park
authors.forename: Si Young
authors.initials: SY
authors.lastname: Song
authors.forename: Hyeyoung
authors.initials: H
authors.lastname: Kim
authors.forename: Kyung Hwan
authors.initials: KH
authors.lastname: Kim
authors.forename: Jin Kyung
authors.initials: JK
authors.lastname: Kang
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010195:Pancreatitis / Q000209:etiology / Q000378:metabolism*; D009195:Peroxidase / Q000097:blood; D011237:Predictive Value of Tests; D011379:Prognosis; D017382:Reactive Oxygen Species / Q000378:metabolism; D012720:Severity of Illness Index; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D008054:Lipid Peroxides; D017382:Reactive Oxygen Species; D009195:Peroxidase; D013482:Superoxide Dismutase