title: Dynamics of cell surface molecules during T cell recognition.
abstract: Recognition of foreign antigens by T lymphocytes is a very important component of vertebrate immunity-vital to the clearance of pathogenic organisms and particular viruses and necessary, indirectly, for the production of high affinity antibodies. T cell recognition is mediated by the systematic scanning of cell surfaces by T cells, which collectively express many antigen receptors. When the appropriate antigenic peptide bound to a molecule of the major histocompatibility complex is found-even in minute quantities-a series of elaborate cell-surface molecule and internal rearrangements take place. The sequence of events and the development of techniques required to observe these events have significantly enhanced our understanding of T cell recognition and may find application in other systems of transient cell:cell interactions as well.
authors.affiliation: Howard Hughes Medical Institute and the Department of Microbiology and Immunology, Stanford University, Stanford, California 94305-5323, USA. mdavis@cmgm.stanford.edu
authors.forename: Mark M
authors.initials: MM
authors.lastname: Davis
authors.forename: Michelle
authors.initials: M
authors.lastname: Krogsgaard
authors.forename: Johannes B
authors.initials: JB
authors.lastname: Huppa
authors.forename: Cenk
authors.initials: C
authors.lastname: Sumen
authors.forename: Marco A
authors.initials: MA
authors.lastname: Purbhoo
authors.forename: Darrell J
authors.initials: DJ
authors.lastname: Irvine
authors.forename: Lawren C
authors.initials: LC
authors.lastname: Wu
authors.forename: Lauren
authors.initials: L
authors.lastname: Ehrlich
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000276:immunology; D008958:Models, Molecular; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
chemical_list: D011948:Receptors, Antigen, T-Cell