title: The chemistry and biochemistry of Spiraea japonica complex.
abstract: The characteristic components of Spiraea japonica complex, which consists of seven varieties, are the hetisine- and atisine-type diterpene alkaloids, and the atisane-type diterpenes. From this complex, 20 hetisines, 37 atisines and 7 diterpenes were isolated during 1964-2001, including the observations of the isomerization of spiraea diterpene alkaloids having the oxazolidine ring and the interconversion of the oxazolidine rings, the configuration of the oxygen substitution at C-15 of the atisine-type alkaloids, and the interconversion relationship between the two main subtypes of the hetisine-type alkaloids. The chemotaxonomy based on structures of the reported diterpene alkaloids were suggested. The studies on the anti-inflammation, anti-platelet aggregation and neuroprotective bioactivities of the alkaloids from S. japonica var. acuta were reviewed as well.
authors.affiliation: The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kuming Institute of Botany, Chinese Academy of Sciences, Heilongtan, Kunming, Yunnan 650204, China. haoxj@mail.kib.ac.cn
authors.forename: Xiaojiang
authors.initials: X
authors.lastname: Hao
authors.forename: Yuemao
authors.initials: Y
authors.lastname: Shen
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Hongping
authors.initials: H
authors.lastname: He
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology; D031992:Spiraea / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D018696:Neuroprotective Agents; D010975:Platelet Aggregation Inhibitors