title: Vitamin D3-dependent pathway regulates TACO gene transcription.
abstract: Recently, gene coding for tryptophan-aspartate containing coat protein (TACO) has been recognized to play a crucial role in the survival of Mycobacterium tuberculosis within human macrophages. Since regulation of TACO gene is still poorly understood, the present study was addressed to explore the role of vitamins (A, C, D, and E) in TACO gene transcription. Such a study revealed that synergistic action of vitamin D(3) and retinoic acid (RA) had inherent ability to down-regulate TACO gene transcription in human macrophages. Based upon these results, we propose that synergistic action of RA+vitamin D may be of importance in the prevention/control of M. tuberculosis infection.
authors.affiliation: Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Paras K
authors.initials: PK
authors.lastname: Anand
authors.forename: Deepak
authors.initials: D
authors.lastname: Kaul
mesh_terms: D002762:Cholecalciferol / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D008264:Macrophages / Q000378:metabolism / Q000382:microbiology; D008840:Microfilament Proteins; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D011110:Polymorphism, Genetic; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics*; D012313:RNA / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000235:genetics; D014158:Transcription, Genetic; D014212:Tretinoin / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism
chemical_list: D008840:Microfilament Proteins; D011506:Proteins; D018167:Receptors, Calcitriol; D014807:Vitamin D; C072061:coronin proteins; D002762:Cholecalciferol; D014212:Tretinoin; D012313:RNA