New lipophilic derivatives of AZT and d4T 5'-phosphonates.
5'-Aminocarbonylphosphonyl and aminocarbonylmethylphosphonyl diesters of AZT and d4T were synthesized as potential anti-HIV agents.
Shirokova
Elena A
EA
Engelhardt Institute of Molecular Biology Russian Academy of Sciences, Moscow, Russia. aak@imb.ac.ru
Jasko
Maxim V
MV
Khandazhinskaya
Anastasiya L
AL
Yanvarev
Dmitry V
DV
Skoblov
Yury S
YS
Pronayeva
Tatyana R
TR
Fedyuk
Nina V
NV
Pokrovsky
Andrey G
AG
Kukhanova
Marina K
MK
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D004355:Drug Stability; D015497:HIV-1 / Q000187:drug effects*; D006207:Half-Life; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D063065:Organophosphonates; D018119:Stavudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D019380:Anti-HIV Agents; D063065:Organophosphonates; D015215:Zidovudine; D018119:Stavudine