title: Hypolipidemic and hypocholesterolemic effect of argan oil (Argania spinosa L.) in Meriones shawi rats.
abstract: The potential health benefits of various dietary oils in relation to cardiovascular disease and cancer are recently receiving considerable attention. The main proposal of this study is to investigate the effect of dietary argan oil, obtained from seeds of Argania spinosa L. (Sapotaceae) endemic from Morocco, on serum lipids composition. Hyperlipidemia was induced by high calorie and cholesterol (HCC) diet administration in 16 rats (Meriones shawi, a rodent of the Gerbillideae family). Eight rats were treated with argan oil (1ml/100g weight) daily by oral route during 7 weeks (treated group). Control animals were also fed with HCC diet for 7 weeks. After 7-week treatment with argan oil, blood lipoproteins were significantly reduced. Total cholesterol decreased with 36.67% (P<0.01), low density lipoprotein (LDL)-cholesterol in 67.70% (P<0.001), triglycerides in 30.67% (P<0.05) and body weight in 12.7% (P<0.05). High density lipoprotein (HDL)-cholesterol concentration remained unaltered. These results indicate the beneficial effect of argan oil in the treatment of the hyperlipidemia and hypercholesterolemia. This effect will be related with the polyunsaturated fatty acids and other constituents of studied oil.
authors.affiliation: School of Pharmacy and Medicine, UFR (Natural Product), University of Pharmacy, Rabat, Morocco.
authors.forename: H
authors.initials: H
authors.lastname: Berrougui
authors.forename: A
authors.initials: A
authors.lastname: Ettaib
authors.forename: M D
authors.initials: MD
authors.lastname: Herrera Gonzalez
authors.forename: M
authors.initials: M
authors.lastname: Alvarez de Sotomayor
authors.forename: N
authors.initials: N
authors.lastname: Bennani-Kabchi
authors.forename: M
authors.initials: M
authors.lastname: Hmamouchi
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D005849:Gerbillinae; D006949:Hyperlipidemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D009018:Morocco; D008517:Phytotherapy; D010938:Plant Oils / Q000627:therapeutic use*; D029632:Sapotaceae; D012639:Seeds
chemical_list: D000924:Anticholesteremic Agents; D000960:Hypolipidemic Agents; D008055:Lipids; D010938:Plant Oils