title: Internal dose assessment in radiation accidents.
abstract: Although numerous models have been developed for occupational and medical internal dosimetry, they may not be applicable to an accident situation. Published dose coefficients relate effective dose to intake, but if acute deterministic effects are possible, effective dose is not a useful parameter. Consequently, dose rates to the organs of interest need to be computed from first principles. Standard bioassay methods may be used to assess body contents, but, again, the standard models for bioassay interpretation may not be applicable because of the circumstances of the accident and the prompt initiation of decorporation therapy. Examples of modifications to the standard methodologies include adjustment of biological half-times under therapy, such as in the Goiania accident, and the same effect, complicated by continued input from contaminated wounds, in the Hanford 241Am accident.
authors.affiliation: Oak Ridge Institute for Science and Education, PO Box 117, MS 23, Oak Ridge, TN 37831, USA. tooheyr@orau.gov
authors.forename: R E
authors.initials: RE
authors.lastname: Toohey
mesh_terms: D000576:Americium / Q000493:pharmacokinetics* / Q000633:toxicity; D001822:Body Burden; D001938:Brazil; D002588:Cesium Radioisotopes / Q000493:pharmacokinetics* / Q000633:toxicity; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D009657:North Carolina; D016273:Occupational Exposure / Q000032:analysis*; D009928:Organ Specificity; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism*; D018788:Radioactive Hazard Release; D011874:Radiometry / Q000379:methods*
chemical_list: D002588:Cesium Radioisotopes; D000576:Americium