title: [Effect of electric stimulation on denervated skeletal muscle atrophy].
abstract: OBJECTIVE
  To study the influence of the electric stimulation of denervated muscle atrophy.
  
  
  METHODS
  Sixteen SD rats were made the model of denervated skeletal muscle in two lower limbs by cutting off the sciatic nerve and femoral nerve. The right gastrocnemius muscle was stimulated with JNR-II nerve & muscle recovery instrument by skin as the experimental side and the left was not treated as the control side. The muscle histology, ultrastructure, fibrillation potential amplitude, Na(+)-K(+)-ATPase and Ca(2+)-ATPase activities were observed 2 weeks and 4 weeks after operation.
  
  
  RESULTS
  Electric stimulation could protect mitochondria and sarcoplasmic reticulum from the degeneration. The reduction rates of muscle cell diameter and cross section in the experimental side were slower significantly than those in control side. There was no influence on fibrillation potential amplitude in the both sides after electric stimulation. The reduction rates of Na(+)-K(+)-ATPase activity in the experimental side were slower 15.59% and 27.38% respectively than those in the control side. The reduction rates of Ca(2+)-ATPase activity in the experimental side were slower 4.83% and 21.64% respectively than those in the control side.
  
  
  CONCLUSIONS
  The electric stimulation can protect muscle histology, electrophysiology and enzymic histochemistry of denervated skeletal muscle from the degeneration. The electric stimulation is an effective method to prevent and treat muscle atrophy.
authors.affiliation: Department of Orthopedics, Sixth People's Hospital, Affilicated Shanghai Jiao Tong University, Shanghai, P. R. China 200233.
authors.forename: Jian-guang
authors.initials: JG
authors.lastname: Xu
authors.forename: Yong-quan
authors.initials: YQ
authors.lastname: Tu
authors.forename: Yu-dong
authors.initials: YD
authors.lastname: Gu
mesh_terms: D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D004558:Electric Stimulation; D004594:Electrophysiology; D005260:Female; D005267:Femoral Nerve / Q000601:surgery; D008297:Male; D009121:Muscle Denervation; D018482:Muscle, Skeletal / Q000098:blood supply / Q000294:innervation / Q000503:physiopathology*; D009133:Muscular Atrophy / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D012584:Sciatic Nerve / Q000601:surgery; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase