Values of fasting glucose levels, glucose tolerance tests, and glucose-insulin ratios as predictors of glucose tolerance.
OBJECTIVE
To examine the ability to use parameters obtainable from an oral glucose tolerance test to predict insulin action as determined under hyperinsulinemic, hyperglycemic conditions.


METHODS
Prospective clinical investigation.


METHODS
University medical center clinical research unit.


METHODS
Healthy male volunteers.


METHODS
Oral glucose tolerance test and hyperglycemic (+125 mg/dL) clamp studies.


METHODS
Glucose and insulin (I) levels, rate of glucose uptake (M) under hyperglycemic conditions, and M/I ratios.


RESULTS
Among individuals with normal glucose tolerance, as assessed by an oral glucose tolerance test, the fasting insulin level is the glucose tolerance test parameter that correlates best with insulin action during a hyperglycemic clamp.


CONCLUSIONS
Measurement of fasting serum insulin levels in conjunction with an oral glucose tolerance test improves the ability to assess insulin action. Such combinations may improve the ability to diagnose insulin-resistant states.
Diamond
Michael P
MP
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University/Detroit Medical Center, Hutzel Hospital, Detroit, Michigan 48201, USA. mdiamond@med.wayne.edu
Chauhan
Subodhsingh
S
Kruger
Michael
M
Subramanian
Marappa
M
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D005215:Fasting / Q000097:blood*; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D006946:Hyperinsulinism / Q000097:blood*; D007328:Insulin / Q000097:blood*; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012016:Reference Values
D001786:Blood Glucose; D007328:Insulin