title: Antimicrobial potentiality of a new non-antibiotic: the cardiovascular drug oxyfedrine hydrochloride.
abstract: Ten cardiovascular drugs, having diverse pharmacological action, were screened for possible antimicrobial property against known eight sensitive bacteria, belonging to Gram positive and Gram negative types. Although five drugs failed to show antimicrobial activity and three had moderate antimicrobial action, oxyfedrine HCl and dobutamine were seen to possess pronounced antimicrobial property. Oxyfedrine was further tested in vitro against 471 strains of bacteria from two Gram positive and fourteen Gram negative genera. The minimum inhibitory concentration (MIC) of oxyfedrine was determined by agar dilution method, which ranged from 50-200 microg/ml in most of the strains, while some strains were inhibited at even lower concentrations. In animal experiments, this compound was capable of offering significant protection to Swiss strain of white mice, challenged with 50 median lethal dose (MLD) of a virulent strain of Salmonella typhimurium at concentrations of 15, 30 and 60 microg/mouse. The in vivo results were highly significant according to chi-square test.
authors.affiliation: Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India.
authors.forename: Kaushiki
authors.initials: K
authors.lastname: Mazumdar
authors.forename: Kumkum
authors.initials: K
authors.lastname: Ganguly
authors.forename: K Asok
authors.initials: KA
authors.lastname: Kumar
authors.forename: N K
authors.initials: NK
authors.lastname: Dutta
authors.forename: A N
authors.initials: AN
authors.lastname: Chakrabarty
authors.forename: Sujata G
authors.initials: SG
authors.lastname: Dastidar
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D010099:Oxyfedrine / Q000494:pharmacology*; D012481:Salmonella Infections, Animal / Q000188:drug therapy; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D002316:Cardiotonic Agents; D002317:Cardiovascular Agents; D010099:Oxyfedrine