title: Long-term efficacy and compliance of intracorporeal (IC) injection for erectile dysfunction following radical prostatectomy: SHIM (IIEF-5) analysis.
abstract: Baseline and follow-up data from 102 patients using intracorporeal (IC) injection for erectile dysfunction (ED) following RP were retrospectively collected. We compared baseline International Index for Erectile Function (IIEF) questionnaires with the abridged IIEF-5 questionnaires, referred to as the Sexual Health Inventory of Men (SHIM) to determine drug efficacy. The mean presurgery SHIM score was 21.75+/-5.23, which decreased to 4.23+/-3.48 after surgery and increased to 19.46+/-8.78 post-treatment. Overall, 68% (69/102) of patients achieved and maintained erections sufficient for sexual intercourse and 48% (49/102) of patients continued long-term therapy with a mean use of 3.7+/-1.9 y. In all, 52% (53/102) patients discontinued IC therapy. However when excluding patients who switched to oral therapy, had loss of partner or return of normal erections; the compliance to IC injections was 70.6% (71/102). There was no difference in the SHIM analysis between the nerve sparing (NS) and the non-NS or between the types of medications used. IC injections can provide excellent long-term efficacy and compliance in up to 70% of the patients. This study suggests that IC injections are an excellent salvage option in NS patients who fail oral therapy and a first option in patients with non-NS procedures.
authors.affiliation: Glickman Urological Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
authors.forename: R
authors.initials: R
authors.lastname: Raina
authors.forename: M M
authors.initials: MM
authors.lastname: Lakin
authors.forename: M
authors.initials: M
authors.lastname: Thukral
authors.forename: A
authors.initials: A
authors.lastname: Agarwal
authors.forename: S
authors.initials: S
authors.lastname: Ausmundson
authors.forename: D K
authors.initials: DK
authors.lastname: Montague
authors.forename: E
authors.initials: E
authors.lastname: Klein
authors.forename: C D
authors.initials: CD
authors.lastname: Zippe
mesh_terms: D000368:Aged; D000527:Alprostadil / Q000008:administration & dosage*; D000959:Antihypertensive Agents / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D007172:Erectile Dysfunction / Q000188:drug therapy*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000008:administration & dosage; D010349:Patient Compliance; D010413:Penis / Q000294:innervation; D010646:Phentolamine / Q000008:administration & dosage; D011468:Prostatectomy; D012189:Retrospective Studies; D016879:Salvage Therapy; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D000959:Antihypertensive Agents; D014665:Vasodilator Agents; D010208:Papaverine; D000527:Alprostadil; D010646:Phentolamine