[Effect of natural enterosorbents in experimental liver disorders].
The effect of enterosorbents of natural origin, zoosterol and sodium alginate, on the main types of metabolism and the macro- and microelement composition (calcium, magnesium, zinc, copper) of the renal tissues was studied in animals with experimental nephrocalcinosis. Increased complex-forming ability of zoosterol, related to a higher absorption activity of low-molecular-weight fragments of this enterosorbent, favors retention of large molecules in the form of calcium salts in the parenchyma. Sodium alginate favors the elimination of calcium compounds and compensates for calcification of the renal tissue, which allows this this enterosorbent to be used as a crystal-inhibiting complex-forming agent for correcting metabolic dysbalance in cases of nephrocalcinosis.
Gvozdenko
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TA
Laboratory of Medical Problems of Cardiovascular and Elimination Systems, Research Institute of Medical Climatology and Rehabilitation Therapy, Vladivostok, Russia.
Ian'kova
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VI
D000464:Alginates / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002614:Chelating Agents / Q000494:pharmacology*; D003300:Copper / Q000378:metabolism; D016061:Enterosorption; D004872:Ergocalciferols; D020723:Glucuronic Acid / Q000494:pharmacology*; D006603:Hexuronic Acids / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008274:Magnesium / Q000378:metabolism; D008297:Male; D009397:Nephrocalcinosis / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000378:metabolism
D000464:Alginates; D002614:Chelating Agents; D004872:Ergocalciferols; D006603:Hexuronic Acids; D011134:Polysaccharides; C070927:zosterin; D003300:Copper; D020723:Glucuronic Acid; D008274:Magnesium; D015032:Zinc; D002118:Calcium