title: Pancreatic fine needle aspiration. A comparison of computed tomographic and endoscopic ultrasonographic guidance.
abstract: OBJECTIVE
  To compare the sensitivity and specificity of pancreatic fine needle aspiration (FNA) with computed tomography (CT) and endoscopic ultrasound (EUS) guidance.
  
  
  METHODS
  A 6-year retrospective review included 137 pancreatic FNAs (CT 51, magnetic resonance imaging 2 or EUS 84). Clinical or histologic follow-up was available for 110 patients.
  
  
  RESULTS
  Positive (POS), suspicious (SUS), atypical, negative and unsatisfactory (UNSAT) results represented 25.5%, 7.3%, 7.3%, 40.1% and 19.1% of reported diagnoses, respectively. In detecting malignancy, the sensitivities of POS/SUS results were 71% and 42% for CT and EUS, respectively, with negative predictive value (NPV) of 41% and 45%. Also, 35% of UNSAT results were found to have malignancy. However, EUS was used on more difficult lesions, including 82% of small, cystic ones and 75% of small, solid ones.
  
  
  CONCLUSIONS
  Although the apparent performance of percutaneous CT-guided biopsies surpasses that of EUS, this is due to the choice of endoscopy for more difficult lesions. The specificity and negative predictive value of EUS and CT are similar.
authors.affiliation: Departments of Pathology, Brigham & Women's Hospital and Beth Israel-Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Qian
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Hecht
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis; D018282:Cystadenocarcinoma, Mucinous / Q000175:diagnosis; D004701:Endocrine Gland Neoplasms / Q000175:diagnosis; D019160:Endosonography / Q000379:methods*; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*