Tunable, monochromatic X-rays: an enabling technology for molecular/cellular imaging and therapy.
Pulsed, tunable, monochromatic X-rays hold great potential as a cellular and molecular probe. These beams can be tuned to the binding energy of orbital electrons in atoms, making them extremely useful in diagnostic k-edge imaging and Auger cascade radiotherapy. Their wide tunability makes them ideal for the performance of various techniques as disparate as protein crystallography and three-dimensional, compressionless, monochromatic mammography. Since only the frequency best suited to the task at hand is used, radiation exposure to patients or animals is exceedingly low when compared to standard X-ray techniques.
Carroll
Frank
F
Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, Tennessee 37235-2675, USA. frank.carroll@vanderbuilt.edu
D000818:Animals; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000532:radiotherapy; D051546:Cyclooxygenase 2; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008565:Membrane Proteins; D051379:Mice; D010024:Osteoporosis / Q000000981:diagnostic imaging; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D014057:Tomography, X-Ray Computed / Q000379:methods*
D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases