The multiple personalities of h-channels.
Concepts regarding the function of the hyperpolarization-activated current (Ih) in shaping the excitability of single cells and neuronal ensembles have been evolving rapidly following the recent cloning of genes that encode the underlying 'h-channels' - the HCN genes. This article reviews new information about the transcriptional regulation of these channels, highlighting novel studies that demonstrate short- and long-term modulation of HCN expression, and linking this modulation to mechanisms of neurological diseases.
Santoro
Bina
B
Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.
Baram
Tallie Z
TZ
D000818:Animals; D054815:Cyclic Nucleotide-Gated Cation Channels; D005786:Gene Expression Regulation; D006801:Humans; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism* / Q000502:physiology; D008564:Membrane Potentials; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism*; D009422:Nervous System Diseases / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D015221:Potassium Channels; D014158:Transcription, Genetic
D054815:Cyclic Nucleotide-Gated Cation Channels; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels; D009419:Nerve Tissue Proteins; D015221:Potassium Channels