title: Specific localization and timing in neuronal signal transduction mediated by protein-lipid interactions.
abstract: A large number of signaling proteins translocate from the cytosol to the plasma membrane in response to receptor and electrical stimuli. The site of translocation to the plasma membrane and the "on" and "off" rates of the translocation process are critical for defining the specificity of the signaling response. In addition to targeting mechanisms based on protein-protein interactions, signaling proteins have evolved a large repertoire of covalent lipid modifications and lipid binding protein modules that regulate reversible membrane association. The time constants of these membrane interactions range from milliseconds to several hours. Here we discuss how diversity in lipid-based membrane anchoring and targeting motifs contributes to plasticity in neuronal signaling by providing local and regional control mechanisms as well as a means to transduce and integrate signals over a broad range of different time scales.
authors.affiliation: Department of Molecular Pharmacology, School of Medicine, Stanford University, 318 Campus Drive, Clark Center W200, Stanford, CA 94305, USA.
authors.forename: Marc
authors.initials: M
authors.lastname: Fivaz
authors.forename: Tobias
authors.initials: T
authors.lastname: Meyer
mesh_terms: D000595:Amino Acid Sequence / Q000502:physiology; D000818:Animals; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000235:genetics; D008969:Molecular Sequence Data; D009474:Neurons / Q000378:metabolism*; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013997:Time Factors
chemical_list: D008055:Lipids; D011506:Proteins