title: New way to deliver fluids: endoscopic jet injection into the beagle prostate.
abstract: OBJECTIVE
  Local therapy of the prostate could have a role in the treatment of benign prostatic hyperplasia as well as prostate cancer. Endoscopic jet injection could simplify these treatments. We evaluated the tissue effects of endoscopic jet injection in an animal model.
  
  
  METHODS
  An endoscopic jet injector was developed. In 12 beagle dogs the prostate was injected with single shot and continuous mode jet injection. Macroscopic and histological analysis was performed 0, 2 and 14 days after jet injection.
  
  
  RESULTS
  Jet injection allowed complete penetration of the beagle prostate. The single shot technique resulted in only minimal tissue effects. However, the continuous mode led to major tissue damage, even complete aseptic necrosis, in the injected area.
  
  
  CONCLUSIONS
  A new method for endoscopic application of fluids is described. Depending on the jet injection technique it could be used to apply pharmaceutical agents or plasmids, and/or induce aseptic necrosis.
authors.affiliation: Department of Urology, University of Cologne, Cologne, Germany.
authors.forename: Gerald
authors.initials: G
authors.lastname: Haupt
authors.forename: Angela
authors.initials: A
authors.lastname: Haupt
authors.forename: Klaus-Dieter
authors.initials: KD
authors.lastname: Richter
authors.forename: Theodor
authors.initials: T
authors.lastname: Senge
mesh_terms: D000818:Animals; D001284:Atrophy; D004285:Dogs; D019723:Endoscopes; D006470:Hemorrhage / Q000473:pathology; D007277:Injections, Jet / Q000295:instrumentation*; D007964:Leukocytosis / Q000473:pathology; D008297:Male; D008751:Methylene Blue / Q000008:administration & dosage; D009336:Necrosis; D011467:Prostate / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000473:pathology*; D012007:Rectum / Q000473:pathology; D000267:Tissue Adhesions; D019459:Urothelium / Q000473:pathology
chemical_list: D008751:Methylene Blue