title: Comparative study of flavonoids in experimental models of inflammation.
abstract: The anti-inflammatory activities of flavonols (quercetin, rutin and morin) and flavanones (hesperetin and hesperidin) were investigated in animal models of acute and chronic inflammation. Rutin was only effective in the chronic process, principally in adjuvant arthritis. On neurogenic inflammation induced by xylene, only the flavanones were effective; besides, these compounds were the most effective on subchronic process. The most important compound in reducing paw oedema induced by carrageenan was quercetin.
authors.affiliation: Cátedra de Farmacología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700 San Luis, Argentina. arotelli@unsl.edu.ar
authors.forename: Alejandra Ester
authors.initials: AE
authors.lastname: Rotelli
authors.forename: Teresita
authors.initials: T
authors.lastname: Guardia
authors.forename: Américo Osvaldo
authors.initials: AO
authors.lastname: Juárez
authors.forename: Nadir Ernesto
authors.initials: NE
authors.lastname: de la Rocha
authors.forename: Lilian Eugenia
authors.initials: LE
authors.lastname: Pelzer
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000517:prevention & control; D002351:Carrageenan; D004195:Disease Models, Animal; D004423:Ear / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005419:Flavonoids / Q000737:chemistry / Q000627:therapeutic use*; D006569:Hesperidin / Q000737:chemistry / Q000627:therapeutic use; D006614:Hindlimb / Q000473:pathology; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D015394:Molecular Structure; D011794:Quercetin / Q000737:chemistry / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012431:Rutin / Q000737:chemistry / Q000627:therapeutic use; D014992:Xylenes; D047309:Flavones
chemical_list: D002351:Carrageenan; D005419:Flavonoids; D006569:Hesperidin; D011794:Quercetin; D012431:Rutin; D014992:Xylenes; C008548:morin; D047309:Flavones; C013015:hesperetin