title: Postoperative hypoxia is a contributory factor to cognitive impairment after cardiac surgery.
abstract: OBJECTIVE
  Cognitive dysfunction and postoperative hypoxia are common sequelae of coronary artery bypass grafting, but there has been no study to determine whether there is any relationship between them.
  
  
  METHODS
  Arterial blood gas measurements were performed before surgical intervention and on the second and fifth postoperative day, and neuropsychological assessments were performed before surgical intervention and 5 days and 3 months postoperatively by using a battery of 10 psychometric tests in 175 patients undergoing coronary artery bypass grafting. An estimate of overall performance on the battery at each assessment point was provided by a simple aggregate cognitive index score calculated from the mean z scores of 4 normally distributed test variables. Multiple regression analysis was performed by using the cognitive index score at day 5 as the dependent variable, with age, sex, duration of the operation, presence or absence of cardiopulmonary bypass, preoperative cognitive index score, and arterial oxygenation and percentage of saturation at day 5 as independent variables.
  
  
  RESULTS
  The mean cognitive index score decreased significantly in 115 (66%) patients who agreed to neuropsychological test battery assessment on the fifth postoperative day but improved significantly beyond baseline at 3 months. Mean arterial oxygen tension and percentage of saturation decreased significantly 2 days after the operation and, although improving over the following 3 days, remained decreased at day 5. Decreased cognitive index scores at day 5 strongly predicted cognitive impairment at 3 months (r = 0.36). The only significant independent predictors of the day 5 cognitive index score in the multiple regression analysis were preoperative cognitive index score and arterial oxygenation tension at day 5 (r = 0.24, P <.03).
  
  
  CONCLUSIONS
  We report a significant correlation between postoperative cognitive dysfunction and hypoxia 5 days after coronary artery bypass grafting. This finding might have therapeutic implications because early postoperative cognitive dysfunction influences long-term impairment.
authors.affiliation: Oxford Heart Centre, John Radcliffe Hospital, Oxford, United Kingdom.
authors.forename: S M
authors.initials: SM
authors.lastname: Browne
authors.forename: P W
authors.initials: PW
authors.lastname: Halligan
authors.forename: D T
authors.initials: DT
authors.lastname: Wade
authors.forename: D P
authors.initials: DP
authors.lastname: Taggart
mesh_terms: D003072:Cognition Disorders / Q000209:etiology*; D001026:Coronary Artery Bypass; D006801:Humans; D000860:Hypoxia / Q000150:complications*; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D011183:Postoperative Complications; D011594:Psychometrics; D012044:Regression Analysis
chemical_list: D010100:Oxygen