Fascination with bacteria-triggered cell death: the significance of Fas-mediated apoptosis during bacterial infection in vivo.
Increasing evidence indicates that bacterial pathogens have developed mechanisms to modulate the apoptotic signaling cascade of host cells and thereby cause disease. The Fas death receptor pathway is one of the most extensively investigated apoptotic signaling pathways. In this review we discuss the role of Fas signaling during the interplay between bacterial pathogens and the host in vivo.
Menaker
Rena J
RJ
Research Institute, Rm. 8409, Hospital for Sick Children, 555 University Avenue, Toronto, Ont., Canada M5G 1X8.
Jones
Nicola L
NL
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001424:Bacterial Infections / Q000473:pathology*; D018407:Bacterial Physiological Phenomena; D006801:Humans; D019014:fas Receptor / Q000235:genetics / Q000502:physiology*
D019014:fas Receptor