title: Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus.
abstract: The aim of the present study was to investigate the association of serum adiponectin concentration with regional adiposity and insulin resistance in subjects with type 2 diabetes mellitus. A total of 73 Japanese men with type 2 diabetes (aged 59 +/- 11 years and body mass index [BMI] 23.8 +/- 3.0 kg/m(2), mean +/- SD) were studied. Fasting serum adiponectin and leptin concentrations were determined by radioimmunoassay. Regional adiposity was measured by abdominal computed tomography (CT) at the umbilical level, and insulin resistance was estimated by homeostasis model assessment (HOMA-R). Univariate regression analysis showed that serum adiponectin levels were negatively correlated with subcutaneous and visceral fat areas. With multivariate regression analysis, visceral fat area was a predominant determinant of serum adiponectin levels. In contrast, subcutaneous fat area was strongly associated with serum leptin concentrations. Among subcutaneous and visceral fat areas, BMI, and serum leptin levels, both subcutaneous and visceral fat areas were independently associated with HOMA-R. In another model incorporating serum adiponectin levels, serum adiponectin levels were selected as an independent determinant of HOMA-R instead of visceral fat area. In conclusion, hypoadiponectinemia was associated with visceral fat accumulation rather than subcutaneous fat depot in Japanese men with type 2 diabetes mellitus. Both subcutaneous and visceral fat accumulation contribute to insulin resistance in these subjects, and the contribution of visceral fat may be mediated, in part, by hypoadiponectinemia.
authors.affiliation: Division of Endocrinology and Metabolism, Jichi Medical School, Tochigi, Japan.
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Yatagai
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Nagasaka
authors.forename: Ataru
authors.initials: A
authors.lastname: Taniguchi
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Fukushima
authors.forename: Tomoatsu
authors.initials: T
authors.lastname: Nakamura
authors.forename: Akira
authors.initials: A
authors.lastname: Kuroe
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Nakai
authors.forename: Shun
authors.initials: S
authors.lastname: Ishibashi
mesh_terms: D052242:Adiponectin; D000273:Adipose Tissue; D000368:Aged; D044466:Asian People; D001823:Body Composition; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D006706:Homeostasis; D006801:Humans; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins; D007564:Japan / Q000208:ethnology; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011506:Proteins / Q000378:metabolism*; D011863:Radioimmunoassay; D014781:Viscera
chemical_list: D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D011506:Proteins