title: Clethramycin, a new inhibitor of pollen tube growth with antifungal activity from Streptomyces hygroscopicus TP-A0623. II. Physico-chemical properties and structure determination.
abstract: Clethramycin is a novel linear polyene polyketide produced by a plant-associated actinomycete Streptomyces hygroscopicus TP-A0623. It possesses a guanidino and carboxyl residue at each end and an O-sulfate group and a hexaene moiety in the molecule, and its molecular formula is C63H99N3O18S. The structure was determined by analyzing 2D-NMR and FAB-MS data, using 13C-enriched compounds. Clethramycin is structurally similar to linearmycin, an inhibitor of spheroplast regeneration in Candida albicans. Clethramycin shows potent antifungal and pollen tube growth inhibitory activity.
authors.affiliation: Biotechnology Research Center, Toyama Prefectural University, 5180, Kurokawa, Kosugi, Toyama 939-0398, Japan. yas@pu-toyama.ac.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Igarashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Iwashita
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Fujita
authors.forename: Hideo
authors.initials: H
authors.lastname: Naoki
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamakawa
authors.forename: Ryuji
authors.initials: R
authors.lastname: Yoshida
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Furuma
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000494:pharmacology; D035264:Flowers / Q000187:drug effects / Q000254:growth & development; D013463:Sulfuric Acid Esters / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; D013463:Sulfuric Acid Esters; C478490:clethramycin