title: New eremophilane sesquiterpenes from Cacalia ainsliaeflora.
abstract: One known eremophilanolide, 3beta-angeloyloxy-8beta,10beta-dihydroxy-6beta-methoxyeremophilenolide (1) and seven new eremophiane sesquiterpenes, 3beta-angeloyloxy-6beta-ethoxy-8beta,10beta-dihydroxyeremophilenolide (2), 3beta,6beta-diangeloyloxy-10alpha-hydroxy-8alpha-methoxyeremophilenolide, 6beta-angeloyloxy-8beta,10beta-dihydroxy-3-oxo-eremophilenolide, 6beta,8beta,10beta-trihydroxy-3-oxo-eremophilenolide, 3beta-angeloyloxy-6beta,10beta-dihydroxy-eremophila-7(11),8(9)-dien-8,12-olide (6), 3beta-angeloyloxy-10beta-hydroxy-6beta-methoxy-eremophila-7(11),8(9)-dien-8,12-olide, 3beta-angeloyloxy-8-oxo-eremophila-6.9-dien-12-oic acid ethyl ester, were isolated from the roots of Cacalia ainsliaeflora. Their structures were elucidated by spectroscopic methods. Compounds 1, 2 and 6 were assayed against both Gram-positive and Gram-negative bacteria. No positive activities were observed.
authors.affiliation: Department of Chemistry, National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, PR China.
authors.forename: Manjun
authors.initials: M
authors.lastname: Mao
authors.forename: Zhongduo
authors.initials: Z
authors.lastname: Yang
authors.forename: Zhongjian
authors.initials: Z
authors.lastname: Jia
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D019659:Asteraceae; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000737:chemistry / Q000494:pharmacology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018517:Plant Roots; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D009281:Naphthalenes; D010936:Plant Extracts; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C018286:eremophilane compounds