title: Synthesis of 4'-C-ethynyl and 4'-C-cyano purine nucleosides from natural nucleosides and their anti-HIV activity.
abstract: Purine 2'-deoxynucleosides bearing an ethynyl or a cyano group at C-4' of the sugar moiety were synthesized from the corresponding 2'-deoxynucleosides. These compounds exhibited very potent anti-HIV activity, and remained active against drug resistant HIV strains.
authors.affiliation: Biochemicals Division, Yamasa Corporation, Choshi, Chiba, Japan. kogo@yamasa.com
authors.forename: Satoru
authors.initials: S
authors.lastname: Kohgo
authors.forename: Kohei
authors.initials: K
authors.lastname: Yamada
authors.forename: Kenji
authors.initials: K
authors.lastname: Kitano
authors.forename: Shinji
authors.initials: S
authors.lastname: Sakata
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hayakawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Nameki
authors.forename: Eiichi
authors.initials: E
authors.lastname: Kodama
authors.forename: Masao
authors.initials: M
authors.lastname: Matsuoka
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Mitsuya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohrui
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003853:Deoxyribonucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D024882:Drug Resistance, Viral; D006147:Guanine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D006678:HIV / Q000145:classification / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D003853:Deoxyribonucleosides; D011684:Purine Nucleosides; D006147:Guanine