Postpartum hemolytic uremic syndrome in a 17-year-old Filipina primigravid.
A 17-year-old Filipina primigravid developed acute renal failure secondary to hemolytic uremic syndrome (HUS) after undergoing emergency cesarean section for severe pre-eclampsia and abruptio placenta. She underwent hemodialysis with concurrent infusions of fresh-frozen plasma and packed red cells for 5 weeks. Renal biopsy revealed findings consistent with HUS with glomerular crescents. She received three doses of pulse methylprednisolone followed by oral prednisone. Renal function improved 5 weeks after the onset of HUS. The pathogenesis, differential diagnosis, and treatment options of postpartum HUS are discussed.
Anacleto
Francisco E
FE
Section of Pediatric Nephrology, Department of Pediatrics, Philippine General Hospital Medical Center, Manila, Philippines 1000. junclets@mailcity.com
Cifra
Christina L
CL
Elises
Joel S
JS
D000037:Abruptio Placentae / Q000601:surgery; D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002585:Cesarean Section; D017707:Erythrocyte Transfusion; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007668:Kidney / Q000473:pathology; D008775:Methylprednisolone / Q000627:therapeutic use; D010949:Plasma; D049590:Postpartum Period; D011225:Pre-Eclampsia / Q000601:surgery; D011241:Prednisone / Q000627:therapeutic use; D011247:Pregnancy; D006435:Renal Dialysis
D000893:Anti-Inflammatory Agents; D011241:Prednisone; D008775:Methylprednisolone