title: Effects of the contrast medium iopromide on renal hemodynamics and oxygen tension in the diabetic rat kidney.
abstract: We investigated the effects of the contrast medium (CM) iopromide on regional renal blood flow and oxygen tension (pO2) in the streptozotocin (STZ)-induced diabetic Wistar Furth rats.
  
  
  RESULTS
  In normoglycemic rats, CM injection induced a transient decrease followed by an increase in renal cortical blood flow (CBF), whereas CBF increased directly in the diabetic animals. Renal outer medullary blood flow (OMBF) increased in controls, while it decreased in the diabetic animals following CM injection. In control rats a marked initial decrease in OM pO2 following injection of CM was observed. In animals diabetic for 4 weeks only a slight decrease was seen, whereas in 9-week diabetic animals a persistent increase was recorded.
  
  
  CONCLUSIONS
  An altered oxygen tension and hemodynamic response to CM was found in diabetic rats. If these disturbances may contribute to the development of renal dysfunction by CM in the diabetic rat kidney remains to be elucidated.
authors.affiliation: Department of Medical Cell Biology, Department of Diagnostic Radiology, Biomedical Center, Box 571, SE-751 23, Uppsala University, Uppsala, Sweden.
authors.forename: Fredrik
authors.initials: F
authors.lastname: Palm
authors.forename: Per-Ola
authors.initials: PO
authors.lastname: Carlsson
authors.forename: Angelica
authors.initials: A
authors.lastname: Fasching
authors.forename: Olof
authors.initials: O
authors.lastname: Hellberg
authors.forename: Anders
authors.initials: A
authors.lastname: Nygren
authors.forename: Peter
authors.initials: P
authors.lastname: Hansell
authors.forename: Per
authors.initials: P
authors.lastname: Liss
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D007472:Iohexol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism* / Q000502:physiology; D008297:Male; D051381:Rats; D011920:Rats, Inbred WF; D013311:Streptozocin
chemical_list: D003287:Contrast Media; D007472:Iohexol; D013311:Streptozocin; C038192:iopromide