title: Association of HLA class I alleles with psoriasis vulgaris in southeastern Chinese Hans.
abstract: BACKGROUND
  Predisposing genetic factors in psoriasis include associations with human leukocyte antigen (HLA). Accumulative evidence has shown that certain HLA at class I locus, especially HLA-Cw6, are associated closely with psoriasis.
  
  
  OBJECTIVE
  To evaluate the association of HLA class I alleles with susceptibility to psoriasis in the southeastern Chinese Han population.
  
  
  METHODS
  We performed genotype for HLA-A, -B and -C loci in 166 patients with psoriasis vulgaris by means of polymerase chain reaction with sequence-specific primers technique. The distribution of HLA allelic frequencies was further analyzed according to age of onset, i.e. under 35-y and beyond 35-y groups. These data were compared with the healthy controls of 204 unrelated Hans.
  
  
  RESULTS
  The frequencies of HLA-A*26 (24.7% vs. 13.1%, OR=2.36, Pc<0.01), -B*13 (27.2% vs. 14.8%, OR=2.34, Pc<0.01), -B*27 (12.2% vs. 4.0%, OR=3.49, Pc<0.01) and -Cw*0602 (17.9% vs. 5.3%, OR=4.20, Pc<0.001) were significantly increased in psoriasis patients, whereas HLA-Cw*0304 frequency (4.9% vs. 13.4%, OR=0.32, Pc<0.01) was highly decreased, when compared to the controls. HLA-A*26-B*27-Cw*0602 was identified as a high-risk haplotype of HLA class I in developing psoriasis in the test. HLA-Cw*0602 was found to be strongly associated with the early-onset psoriasis (age of onset <35 y).
  
  
  CONCLUSIONS
  This study demonstrated the positive associations of HLA class I markers with psoriasis vulgaris, of which HLA-Cw*0602 was the strongest susceptibility determinant for development of early-onset psoriasis, in the southeastern Chinese Han population.
authors.affiliation: Institute of Dermatology, Anhui Medical University, No. 69 Meishan Road, Hefei, Anhui 230032, PR China. ayzxj@mail.hf.ah.cn
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Zhang
authors.forename: An-Ping
authors.initials: AP
authors.lastname: Zhang
authors.forename: Sen
authors.initials: S
authors.lastname: Yang
authors.forename: Min
authors.initials: M
authors.lastname: Gao
authors.forename: Sheng-Cai
authors.initials: SC
authors.lastname: Wei
authors.forename: Ping-Ping
authors.initials: PP
authors.lastname: He
authors.forename: Hong-Yan
authors.initials: HY
authors.lastname: Wang
authors.forename: Ying-Xue
authors.initials: YX
authors.lastname: Song
authors.forename: Yong
authors.initials: Y
authors.lastname: Cui
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D017668:Age of Onset; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D015395:Histocompatibility Antigens Class I