PRESS-based proton single-voxel spectroscopy and spectroscopic imaging with very short echo times using asymmetric RF pulses.
Modified point-resolved spectroscopy (PRESS) sequences for single voxel spectroscopy (MRS) and spectroscopic imaging (SI) with very short echo time ( T(E)) are described using asymmetric radio-frequency (RF) pulses as well as an optimized design and timing of the PRESS sequence. The proposed sequences were implemented on a standard 4.7 T imaging system yielding a T(E) of 6.0 ms only. Simulations and experimental data measured on phantoms and the rat brain in vivo are presented for MRS and SI showing a high signal-to-noise ratio and hardly any phase distortions caused by J-coupling.
Geppert
Christian
C
Fachbereich 2 (Chemie), Universität Bremen, Leobener Strasse, 28334 Bremen, Germany.
Dreher
Wolfgang
W
Leibfritz
Dieter
D
D000465:Algorithms; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D001931:Brain Mapping / Q000379:methods; D007089:Image Enhancement / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D019047:Phantoms, Imaging; D011846:Radio Waves; D051381:Rats; D012815:Signal Processing, Computer-Assisted