title: [Autoimmune hepatitis and anti-Ro antibodies. Is there a link?].
abstract: Antinuclear antibodies (ANA) are considered to be markers of autoimmune disease. Several specific reactivities of ANA are known, among them the Ro (SS-a) complex. Although the presence of anti-Ro antibodies is widely known in systemic connective tissue diseases such as lupus erythematous or Sjögren's syndrome, few studies have attempted to link this finding with autoimmune hepatitis (AIH). We present a case of acute AIH in a 55-year-old woman who tested positive for anti-Ro 60 kD antibodies. The Ro (SS-A) antigen is a complex ribonucleoprotein whose structure is still the subject of debate. Two fractions, of 50 and 60 kD, have been identified. A review of the literature revealed frequencies of 21-34% for anti-Ro 52 kD and of 9-13-6% for anti-Ro 60 kD in AIH. Although no relationship has been demonstrated between this complex and the etiopathogenic mechanisms or clinical patterns of AIH, we propose that multicenter investigations with large series should be performed before the possible involvement of anti-Ro antibodies in these diseases is definitively ruled out.
authors.affiliation: Unidad de Aparato Digestivo. Servicio de Medicina Interna. Hospital Francesc de Borja. Gandia. Valencia. España. devesa_fra@gva.es
authors.forename: F
authors.initials: F
authors.lastname: Devesa I Jordà
authors.forename: J
authors.initials: J
authors.lastname: Ferrando Ginestar
authors.forename: M
authors.initials: M
authors.lastname: Bustamante Balén
authors.forename: J
authors.initials: J
authors.lastname: Ortuño Cortés
authors.forename: A
authors.initials: A
authors.lastname: Borghol Hariri
authors.forename: J A
authors.initials: JA
authors.lastname: Ramos Níguez
authors.forename: A
authors.initials: A
authors.lastname: Jiménez Sánchez
authors.forename: S
authors.initials: S
authors.lastname: Mery Rams
authors.forename: S
authors.initials: S
authors.lastname: Rull Segura
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood*; D001324:Autoantigens; D005260:Female; D019693:Hepatitis, Autoimmune / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins / Q000276:immunology; D000099207:SS-A Antigen
chemical_list: D000974:Antibodies, Antinuclear; D001324:Autoantigens; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human; C035356:SS-A antibodies