Red blood cell antigens responsible for inherited types of polyagglutination.
The three described types on inheritable polyagglutination are related to altered carbohydrate structures in glycoproteins or/and glycolipds on the erythrocyte surface. HEMPAS, a condition causing anemia and other pathological symptoms, is characterized by impaired biosynthesis of N-glycans, mostly those carried by band 3 and band 4.5 erythrocyte membrane proteins. Cad erythrocytes have abnormal glycophorin O-glycans, structurally related to the more common human Sd(a) and murine CT determinants, and accumulate an Sd(a)-like ganglioside. NOR erythrocytes express recently detected abnormal alpha-galactose-terminated glycosphingolipids, which strongly react with G. simplicifolia IB4 isolectin, but do not react with human anti-Galalpha1-3Gal antibodies.
Lisowska
E
E
Department of Immunochemistry, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.
Duk
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M
D000742:Anemia, Dyserythropoietic, Congenital / Q000097:blood / Q000235:genetics / Q000276:immunology; D000941:Antigens / Q000097:blood* / Q000737:chemistry / Q000235:genetics; D001789:Blood Group Antigens / Q000737:chemistry / Q000235:genetics / Q000276:immunology; D002240:Carbohydrate Sequence; D004912:Erythrocytes / Q000276:immunology*; D006384:Hemagglutination / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000097:blood / Q000737:chemistry / Q000276:immunology
D000941:Antigens; D001789:Blood Group Antigens; D009844:Oligosaccharides