Towards a DNA-like duplex without hydrogen bonds.
The inverse quadrupolar moments of the phenyl and pentafluorophenyl residues in the base pair P-F5 promotes strong intramolecular stacking interactions in DNA duplexes. The more natural base pairs are replaced by this novel pair the higher the thermodynamic stability of the resulting duplex if they are arranged in an alternating fashion.
Mathis
Gérald
G
Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland. gerald.mathis@ioc.unibe.ch
Schütz
Rolf
R
Hunziker
Jürg
J
D002151:Calorimetry; D004247:DNA / Q000737:chemistry*; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D013816:Thermodynamics
D009838:Oligodeoxyribonucleotides; D004247:DNA