title: Conformationally restricted dinucleotides: tandem ring-closing metathesis and hydrogenation approach.
abstract: Cyclic dinucleotides with saturated connections between a nucleobase and the phosphate are synthesised using a tandem ring-closing metathesis (RCM) and hydrogenation protocol and found to be significantly stabilised towards ammonia.
authors.affiliation: Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark.
authors.forename: Philip
authors.initials: P
authors.lastname: Børsting
authors.forename: Poul
authors.initials: P
authors.lastname: Nielsen
mesh_terms: D018900:Dinucleotide Repeats; D007202:Indicators and Reagents; D009690:Nucleic Acid Conformation; D009711:Nucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D007202:Indicators and Reagents; D009711:Nucleotides