title: Validation of a probabilistic model of dietary exposure to selected pesticides in Dutch infants.
abstract: A probabilistic model for dietary exposure to pesticides was validated. For this, we evaluated the agreement of dietary exposure to six pesticides as estimated with the model with exposures measured in duplicate diet samples (='real intake') and those calculated with the point estimate. To calculate the exposure with the model and point estimate, consumption data of the duplicate diet survey and pesticide residue measurements from Dutch monitoring programmes in 2000 and 2001 were used. The model was considered validated when the outcome was both higher than the real intake and lower than the point estimate. Results showed that exposures estimated with the model were closer to the real intake than those of the point estimate, and that the model outcome was lower than the point estimate. Furthermore, it was shown that the probabilistic approach can address the exposure to a pesticide via the consumption of different food products, while the point estimate only estimates the exposure through the consumption of one product. The model validated is a valuable asset when estimating the dietary exposure to pesticides in both the authorization of new pesticides and the evaluation of exposures using monitoring data.
authors.affiliation: RIKILT-Institute of Food Safety, Wageningen University and Research Centre, The Netherlands. polly.boon@wur.nl
authors.forename: P E
authors.initials: PE
authors.lastname: Boon
authors.forename: H
authors.initials: H
authors.lastname: van der Voet
authors.forename: J D
authors.initials: JD
authors.lastname: van Klaveren
mesh_terms: D004032:Diet; D005504:Food Analysis; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D007223:Infant; D015233:Models, Statistical; D009426:Netherlands; D010573:Pesticide Residues / Q000032:analysis*; D015203:Reproducibility of Results
chemical_list: D010573:Pesticide Residues