title: Assessment of global and regional left ventricular diastolic function in hypertensive heart disease using automated border detection techniques.
abstract: Acoustic quantification (AQ) and color kinesis (CK) are techniques that involve automated detection and tracking of endocardial borders. These methods are useful for the evaluation of global and regional left ventricular (LV) systolic function and more recently have been applied to evaluating LV diastolic performance. Assessment of diastolic dysfunction in hypertensive heart disease is a relevant clinical issue in which these techniques have proven useful. The diastolic portion of left atrium and LV AQ area waveforms are frequently abnormal in patients with left ventricular hypertrophy (LVH). Left ventricular AQ curves consistently demonstrate reduced rapid filling fraction (RFF) and peak rapid filling rate (PRFR), elevated atrial filling fraction (AFF), peak atrial filling rate (PAFR), and reductions in the ratio PRFR/PAFR. Acoustic quantification complements traditional Doppler echocardiographic evaluation of global diastolic function. Many patients with significant LVH and normal Doppler diastolic parameters can be identified as having diastolic dysfunction with AQ. In addition, CK has allowed the evaluation of regional diastolic performance in hypertensive patients. Regional filling curves obtained from CK have demonstrated that endocardial diastolic motion is commonly delayed and heterogeneous in patients with LVH.
authors.affiliation: Noninvasive Cardiac Imaging Laboratories, Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA. kspencer@medicine.bsd.uchicago.edu
authors.forename: Kirk T
authors.initials: KT
authors.lastname: Spencer
authors.forename: Roberto M
authors.initials: RM
authors.lastname: Lang
authors.forename: James N
authors.initials: JN
authors.lastname: Kirkpatrick
authors.forename: Victor
authors.initials: V
authors.lastname: Mor-Avi
mesh_terms: D003971:Diastole; D004452:Echocardiography / Q000379:methods*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology; D012815:Signal Processing, Computer-Assisted; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology