title: fMRI for monitoring dynamic changes in tissue oxygenation/blood flow: potential applications for tumor response to carbogen treatment.
abstract: The ability to differentiate between well-oxygenated and poorly-oxygenated tumors may play an important role in selecting an optimal therapeutic regime for tumor treatment of the individual patient. We present preliminary results in the development of a dynamic functional MRI method for mapping tissue oxygenation and blood flow distribution in humans simultaneously. We applied interleaved Blood Oxygenation Level Dependent (BOLD) and Flow-sensitive Alternating Inversion Recovery (FAIR) sequences to detect signals as a subject is inspiring gases of varying oxygen concentration. The method allows quantitation of the spatial distribution and time course of the important physiological functions that are easily registered with high resolution anatomic MR images. It may be used to critically evaluate the efficacy of varying durations of carbogen breathing in tumor patients, and allow a quantitative evaluation of the roles of carbogen and other radiosensitizers as potential adjuncts to radiotherapy and drug therapies.
authors.affiliation: Department of Radiology, Biomedical Engineering, University of Rochester, Rochester, NY, USA.
authors.forename: Jianhui
authors.initials: J
authors.lastname: Zhong
authors.forename: W C
authors.initials: WC
authors.lastname: Kwok
authors.forename: Paul
authors.initials: P
authors.lastname: Okunieff
mesh_terms: D002245:Carbon Dioxide / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism* / Q000627:therapeutic use*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D012039:Regional Blood Flow
chemical_list: D011838:Radiation-Sensitizing Agents; D002245:Carbon Dioxide; C011700:carbogen; D010100:Oxygen