No association between two polymorphisms at the 5HT2A gene and bipolar affective puerperal psychosis.
OBJECTIVE
To examine whether variation at two common polymorphisms, T102C and -1438AG, of the serotonin 2A gene (5HT2A) are involved in the puerperal triggering mechanism of bipolar affective puerperal psychosis.


METHODS
A total of 242 parous women diagnosed with bipolar disorder were genotyped for the two polymorphisms. Of these, 165 women had experienced a manic or psychotic episode, according to DSM-IV criteria, within 6 weeks of childbirth (the puerperal psychosis group). The comparison group comprised of 77 parous women who had not experienced psychiatric disturbance following childbirth.


RESULTS
No significant differences between genotype or allelic frequencies were found between the two groups for either polymorphism.


CONCLUSIONS
The results indicate that variation at two common polymorphisms of the 5HT2A gene does not appear to play a major role in the development of bipolar affective puerperal psychosis.
Robertson
E
E
Department of Psychiatry, Division of Neuroscience, Queen Elizabeth Psychiatric Hospital, University of Birmingham, Edgbaston, Birmingham, UK.
Jones
I
I
Middle
F
F
Moray
J
J
Craddock
N
N
D000328:Adult; D000483:Alleles; D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D011644:Puerperal Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012016:Reference Values; D012307:Risk Factors
D044402:Receptor, Serotonin, 5-HT2A