title: Synthesis and antitumor activity of N-sulfonyl derivatives of nucleobases and sulfonamido nucleoside derivatives.
abstract: The introduction of sulfonamido group on the C-2 position of pyrimidine nucleosides was achieved by ring opening of 2,2'- and 2,3'-anhydronucleosides. N-sulfonyl derivatives of nucleobases and sulfonamido derivatives of nucleosides were assayed for in vitro antitumor activity.
authors.affiliation: Ruder Bosković Institute, Zagreb, Croatia. bzinic@rudjer.irb.hr
authors.forename: B
authors.initials: B
authors.lastname: Zinić
authors.forename: I
authors.initials: I
authors.lastname: Krizmanić
authors.forename: Lj
authors.initials: Lj
authors.lastname: Glavas-Obrovac
authors.forename: I
authors.initials: I
authors.lastname: Karner
authors.forename: M
authors.initials: M
authors.lastname: Zinić
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D005472:Fluorouracil / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007700:Kinetics; D015394:Molecular Structure; D009705:Nucleosides / Q000494:pharmacology*; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D009705:Nucleosides; D011684:Purine Nucleosides; D011741:Pyrimidine Nucleosides; D013449:Sulfonamides; D005472:Fluorouracil