title: Abnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study.
abstract: Diffusion tensor imaging (DTI) can non-invasively examine the molecular diffusion of water in vivo and directly reflects the anatomical integrity of neural fibers in white matter. Fractional anisotropy (FA) can be calculated from DTI data, and utilized to evaluate white matter integrity. DTI was performed on 30 patients with schizophrenia and 19 healthy controls, and their FA values were subsequently measured in multiple brain regions. Statistical analyses revealed that FA values were decreased in the anterior cingulum of schizophrenia subjects. There were no significant differences between patients and controls in any other regions. This study supports the hypothesis that schizophrenia is associated with abnormal white matter integrity of the anterior cingulum.
authors.affiliation: Department of Radiology, 11 South Xizhimen St, People's Hospital, Peking University, Beijing 100044, China.
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Sun
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Liwei
authors.initials: L
authors.lastname: Cui
authors.forename: Janis
authors.initials: J
authors.lastname: Breeze
authors.forename: Xiangke
authors.initials: X
authors.lastname: Du
authors.forename: Xilin
authors.initials: X
authors.lastname: Wang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Cong
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.forename: Nan
authors.initials: N
authors.lastname: Hong
authors.forename: Dai
authors.initials: D
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D016022:Case-Control Studies; D004058:Diffusion; D001330:Electronic Data Processing; D005260:Female; D006179:Gyrus Cinguli / Q000002:abnormalities* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D012559:Schizophrenia / Q000473:pathology / Q000503:physiopathology*