Acquired prion disease: iatrogenic CJD, variant CJD, kuru.
Human prion diseases can be classified as sporadic, hereditary or acquired. The cause of sporadic Creutzfeldt-Jakob disease (CJD) is unknown, hereditary cases are associated with mutations of the prion protein gene (PRNP) and acquired forms are caused by the transmission of infection from human to human or, as a zoonosis, from cattle to human. Although acquired forms of human prion disease are rare, the transmission of a fatal and untreatable neurological disorder has had major implications for public health and public policy.
Will
Robert G
RG
National CJD Surveillance Unit, Department of Clinical Neuroscience, Western General Hospital, Edinburgh, UK.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000682:Amyloid / Q000235:genetics; D000818:Animals; D002417:Cattle; D002648:Child; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D004032:Diet; D004196:Disease Outbreaks; D004566:Electrodes; D016643:Encephalopathy, Bovine Spongiform / Q000453:epidemiology / Q000635:transmission; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy; D013006:Growth Hormone / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007049:Iatrogenic Disease; D007729:Kuru / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010219:Papua New Guinea / Q000453:epidemiology; D017096:Prion Diseases / Q000453:epidemiology / Q000209:etiology*; D000072002:Prion Proteins; D011328:Prions; D011498:Protein Precursors / Q000235:genetics; D012306:Risk; D013525:Surgical Instruments; D014180:Transplantation; D015047:Zoonoses
D000682:Amyloid; C512656:PRNP protein, human; D000072002:Prion Proteins; D011328:Prions; D011498:Protein Precursors; D013006:Growth Hormone