title: Inhibitory effect of trans-N-p-coumaroyl tryamine from the twigs of Celtis chinensis on the acetylcholinesterase.
abstract: The methanolic extract of the twigs of Celtis chinensis was found to show inhibitory activity on acetylcholinesterase (AChE), an enzyme that plays a role in the metabolic hydrolysis of ACh. Bioassay-guided fractionation of the methanolic extract resulted in the isolation of N-p-coumaroyl tyramine, as an inhibitor on AChE. This compound inhibited AChE activity in a dose-dependent manner, and the IC50 value of trans-N-p-coumaroyl tyramine was 34.5 microg/mL (122 microM).
authors.affiliation: College of Pharmacy, Woosuk University, Samrye 565-701, Korea. dkkim@woosuk.ac.kr
authors.forename: Dae Keun
authors.initials: DK
authors.lastname: Kim
authors.forename: Kieseung
authors.initials: K
authors.lastname: Lee
mesh_terms: D000109:Acetylcholine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D005591:Chemical Fractionation / Q000379:methods; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005544:Forecasting; D005625:Frontal Lobe / Q000166:cytology / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008518:Medicine, East Asian Traditional; D000432:Methanol; D051379:Mice; D008813:Mice, Inbred ICR; D024301:Plant Bark / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D010946:Plants, Medicinal; D014439:Tyramine / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology*; D034401:Ulmaceae
chemical_list: D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; C487400:trans-N-p-coumaroyl tyramine; D000109:Acetylcholine; D014439:Tyramine; D000432:Methanol