Self-aggregation behavior of alkylated chitosan and its effect on the release of a hydrophobic drug.
Chitosan (CS) was hydrophobically modified with butyl bromide and dodecyl bromide. The self-aggregation in acetic acid solution was characterized by fluorescence spectroscopy and dynamic light-scattering method. The results indicate that introducing butyl and dodecyl moieties leads to the formation of self-aggregates. Along with the enhancement in the hydrophobicity of chitosan the self-association occurs at a lower concentration, and the mean size of self-aggregates increases. The loading capacity of butylated chitosan (4-CS) and dodecylated chitosan (12-CS) for vitamin B2 are markedly increased compared to that of chitosan, and the release of drug from alkylated chitosans is somewhat hindered due to its increased affinity for hydrophobic carriers.
Liu
Wenguang
W
Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, PR China. wgliu@tju.edu.cn
Sun
Shu Jun
SJ
Zhang
Xin
X
Yao
Kang De
KD
D000478:Alkylation; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry*; D048271:Chitosan; D004337:Drug Carriers / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D010539:Permeability; D011721:Pyrenes; D012256:Riboflavin / Q000737:chemistry* / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
D004337:Drug Carriers; D011721:Pyrenes; D002686:Chitin; D048271:Chitosan; C030984:pyrene; D012256:Riboflavin