title: A novel series of histone deacetylase inhibitors incorporating hetero aromatic ring systems as connection units.
abstract: A series of structurally novel HDAC inhibitors, in which a hetero aromatic ring connects the spacer with the hydrophobic group, has been designed and synthesized. These new inhibitors are very potent in in vitro enzymatic assays and display antiproliferation activity against two human cancer cell lines.
authors.affiliation: Cancer Research, Abbott Laboratories, Department R47J, Building AP10, 100 Abbott Park Road, Abbott Park, IL 60031, USA. yujia.dai@abbott.com
authors.forename: Yujia
authors.initials: Y
authors.lastname: Dai
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.forename: Michael L
authors.initials: ML
authors.lastname: Curtin
authors.forename: Junling
authors.initials: J
authors.lastname: Li
authors.forename: Lori J
authors.initials: LJ
authors.lastname: Pease
authors.forename: Jun
authors.initials: J
authors.lastname: Guo
authors.forename: Patrick A
authors.initials: PA
authors.lastname: Marcotte
authors.forename: Keith B
authors.initials: KB
authors.lastname: Glaser
authors.forename: Steven K
authors.initials: SK
authors.lastname: Davidsen
authors.forename: Michael R
authors.initials: MR
authors.lastname: Michaelides
mesh_terms: D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D056572:Histone Deacetylase Inhibitors; D006801:Humans; D006877:Hydroxamic Acids / Q000037:antagonists & inhibitors / Q000494:pharmacology; D007202:Indicators and Reagents; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D006877:Hydroxamic Acids; D007202:Indicators and Reagents