Neuronal ceroid-lipofuscinosis in a Labrador Retriever.
An 8-year-old Labrador Retriever with an 11-month history of progressive partial seizures and necropsy examination findings characteristic of the lamellar form of canine neuronal ceroid-lipofuscinosis (NCL) is presented. The clinical, light microscopic, and ultrastructural features of this case most closely resemble human adult-onset NCL (Kufs disease). This is the first report of NCL occurring in the Labrador Retriever breed.
Rossmeisl
John H
JH
Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Duncan
Robert
R
Fox
Jonathan
J
Herring
Erin S
ES
Inzana
Karen D
KD
D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D008297:Male; D009046:Motor Neurons / Q000473:pathology / Q000648:ultrastructure; D009472:Neuronal Ceroid-Lipofuscinoses / Q000473:pathology / Q000662:veterinary*; D010487:Periaqueductal Gray / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology