Comparison of acute hemodynamic effects of aerosolized and intravenous iloprost in secondary pulmonary hypertension in children with congenital heart disease.
Both aerosolized and intravenous infusion of iloprost caused a significant decrease in mean pulmonary artery pressure and pulmonary vascular resistance. Although intravenous infusion caused a large decrease in mean systemic arterial pressure, this was only slightly affected by aerosolized iloprost. Aerosolized iloprost caused a significant decrease in the pulmonary-to-systemic vascular resistance ratio; however, intravenous infusion did not cause a prominent decrease in this ratio.
Hallioglu
Olgu
O
Department of Pediatrics, Section of Pediatric Cardiology, Hacettepe University, Ankara, Turkey.
Dilber
Embiya
E
Celiker
Alpay
A
D000280:Administration, Inhalation; D000293:Adolescent; D000336:Aerosols; D002648:Child; D002675:Child, Preschool; D006330:Heart Defects, Congenital / Q000150:complications; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D007022:Hypotension / Q000139:chemically induced; D016285:Iloprost / Q000008:administration & dosage* / Q000009:adverse effects; D007223:Infant; D007262:Infusions, Intravenous; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects
D000336:Aerosols; D014665:Vasodilator Agents; D016285:Iloprost