No evidence for association between the polymorphism in the 3' untranslated region of interleukin-12B and human susceptibility to tuberculosis.
Interleukin (IL)-12 plays a pivotal role in cell-mediated immunity to Mycobacterium tuberculosis infection. We tested the association between a biallelic single-nucleotide polymorphism in the 3' untranslated region (UTR) of IL-12B and human susceptibility to tuberculosis (TB), in a population-based case-control study of adult patients with TB from 2 ethnicities, African American and white, and in a family-based transmission/disequilibrium study of 60 informative families with at least 1 pediatric patient with TB and 1 heterozygous parent. Our results suggest that IL-12B 3' UTR has no effect or has a negligible effect on human susceptibility to TB.
Ma
Xin
X
Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.
Reich
Robert A
RA
Gonzalez
Omar
O
Pan
Xi
X
Fothergill
Amanda K
AK
Starke
Jeffery R
JR
Teeter
Larry D
LD
Musser
James M
JM
Graviss
Edward A
EA
D020413:3' Untranslated Regions / Q000235:genetics*; D000328:Adult; D044383:Black People; D016022:Case-Control Studies; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics*; D053762:Interleukin-12 Subunit p40; D015810:Linkage Disequilibrium; D008297:Male; D009169:Mycobacterium tuberculosis; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D014397:Tuberculosis, Pulmonary / Q000208:ethnology / Q000235:genetics*; D044465:White People; D001741:Black or African American
D020413:3' Untranslated Regions; C500879:IL12B protein, human; D053762:Interleukin-12 Subunit p40; D018664:Interleukin-12