title: A non-invasive method for observing hippocampal function.
abstract: A non-invasive method for observing the functioning of the hippocampus could be invaluable in understanding the role of hippocampal abnormalities in many brain disorders. Transverse patterning, a hippocampal-dependent memory task, was used in an attempt to study the functioning hippocampus. Subjects performed transverse patterning while whole-head MEG data were collected. The MEG data were analyzed using a spatial-temporal multiple-dipole approach. Controls showed right hippocampal activation. Patients with unilateral hippocampal damage showed activation in undamaged hippocampus. MEG during transverse patterning performance is a promising, non-invasive tool for assessing hippocampal function.
authors.affiliation: New Mexico VA Health Care System, 1501 San Pedro Drive, SE Albuquerque, NM 87108, USA.
authors.forename: Faith M
authors.initials: FM
authors.lastname: Hanlon
authors.forename: Michael P
authors.initials: MP
authors.lastname: Weisend
authors.forename: Mingxiong
authors.initials: M
authors.lastname: Huang
authors.forename: Roland R
authors.initials: RR
authors.lastname: Lee
authors.forename: Sandra N
authors.initials: SN
authors.lastname: Moses
authors.forename: Kim M
authors.initials: KM
authors.lastname: Paulson
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Thoma
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Miller
authors.forename: Jose M
authors.initials: JM
authors.lastname: Cañive
mesh_terms: D000328:Adult; D005260:Female; D006624:Hippocampus / Q000293:injuries / Q000473:pathology / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D009010:Monte Carlo Method; D010775:Photic Stimulation; D012598:Sclerosis; D013702:Temporal Lobe / Q000293:injuries / Q000473:pathology; D014202:Tremor / Q000473:pathology