title: [Quantitative analysis of contrast enhanced MRI of the inferior alveolar nerve in inflammatory changes of the mandible].
abstract: OBJECTIVE
  To evaluate the role of contrast enhanced MRI in quantifying signal changes of the inferior alveolar nerve following inflammatory changes of the mandible.
  
  
  METHODS
  30 patients with inflammatory changes of the mandible underwent MRI of the face. Both sides of the mandible, the affected as well as the unaffected healthy side were evaluated retrospectively. Regions of interest were placed at 5 defined places on both sides to assess signal intensity before and after intravenous application of paramagnetic contrast agent. The results of the measurements were compared between the healthy and the affected side (t-test, p < 0.05) and correlated with clinical findings (t-test, p < 0.05).
  
  
  RESULTS
  All patients with hypesthesia of the inferior alveolar nerve in areas of the lips or chin (n = 4) showed a marked increase in signal intensity from 35 % to 83 % distal to the inflammatory process. Patients without sensitivity disorders showed less increase in signal intensity with a maximum of 51 % distal to the inflammatory process. In nearly all patients no contrast enhancement was observed distal to the first molar on the unaffected side.
  
  
  CONCLUSIONS
  Quantitative analysis of contrast enhanced MRI of the neurovascular bundle is able to show pathologic mandibular lesions. In case of inflammatory changes of the mandible the neurovascular bundle is able to show pathologic mandibular lesions. In case of inflammatory changes of the mandible, the neurovascular bundle shows a significant increase in signal intensity distal to the lesion compared to the unaffected healthy side of the mandible.
authors.affiliation: Abteilung Radiologie Bundeswehrkrankenhaus Ulm. A1.Gottschalk@T-Online.de
authors.forename: A
authors.initials: A
authors.lastname: Gottschalk
authors.forename: S
authors.initials: S
authors.lastname: Gerber
authors.forename: T
authors.initials: T
authors.lastname: Solbach
authors.forename: L
authors.initials: L
authors.lastname: Anders
authors.forename: W
authors.initials: W
authors.lastname: Bähren
authors.forename: B
authors.initials: B
authors.lastname: Kress
mesh_terms: D000293:Adolescent; D000328:Adult; D002680:Chin / Q000294:innervation; D003389:Cranial Nerve Diseases / Q000175:diagnosis*; D005260:Female; D006801:Humans; D006987:Hypesthesia / Q000175:diagnosis / Q000209:etiology; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008046:Lip / Q000294:innervation; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008334:Mandible / Q000294:innervation / Q000473:pathology; D008336:Mandibular Diseases / Q000175:diagnosis*; D008340:Mandibular Nerve / Q000473:pathology*; D008875:Middle Aged; D008963:Molar / Q000294:innervation; D010508:Periodontal Abscess / Q000175:diagnosis; D010518:Periodontitis / Q000175:diagnosis; D011671:Pulpitis / Q000175:diagnosis; D012016:Reference Values; D015203:Reproducibility of Results