title: Tetracyclines for treating multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia.
abstract: OBJECTIVE
  To report the use of tetracyclines for the treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP).
  
  
  METHODS
  Observational case series.
  
  
  METHODS
  . The Presley Regional Trauma Center located within the Regional Medical Center, Memphis, Tennessee, USA.
  
  
  METHODS
  Seven critically ill trauma patients with VAP caused by A. baumannii isolates that were resistant to all antibiotics tested except for doxycycline or minocycline.
  
  
  METHODS
  Patients were treated with IV doxycycline or minocycline for an average of 13.5 (range 9-20) days.
  
  
  RESULTS
  Doxycycline or minocycline was successful in six of seven patients.
  
  
  CONCLUSIONS
  Doxycycline or minocycline may be effective for treating multidrug-resistant A. baumannii VAP.
authors.affiliation: Department of Clinical Pharmacy, The University of Tennessee College of Pharmacy, 26 South Dunlap, Memphis, Tennessee 38163, USA. cwood@utmem.edu
authors.forename: G Christopher
authors.initials: GC
authors.lastname: Wood
authors.forename: Scott D
authors.initials: SD
authors.lastname: Hanes
authors.forename: Bradley A
authors.initials: BA
authors.lastname: Boucher
authors.forename: Martin A
authors.initials: MA
authors.lastname: Croce
authors.forename: Timothy C
authors.initials: TC
authors.lastname: Fabian
mesh_terms: D018806:APACHE; D000151:Acinetobacter Infections / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D040981:Acinetobacter baumannii; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D003422:Critical Care / Q000379:methods; D016638:Critical Illness; D003428:Cross Infection / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D004318:Doxycycline / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D017053:Infection Control / Q000379:methods; D007262:Infusions, Intravenous; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D008911:Minocycline / Q000627:therapeutic use*; D018410:Pneumonia, Bacterial / Q000188:drug therapy / Q000209:etiology / Q000401:mortality; D012121:Respiration, Artificial / Q000009:adverse effects*; D012189:Retrospective Studies; D013714:Tennessee / Q000453:epidemiology; D014193:Trauma Centers; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D008911:Minocycline; D004318:Doxycycline