What brings pericytes to tumor vessels?
Paracrine signaling via platelet-derived growth factor B (PDGFB), expressed by endothelial cells, and its receptor PDGFR-beta, expressed by pericytes, plays a central role in blood vessel maturation. A new study (see the related article beginning on page 1142) reveals that it is not just the presence of PDGFB, but how it is presented to pericytes, that determines the quality of the endothelium-pericyte interaction.
Jain
Rakesh K
RK
Edwin L. Steele Laboratory, Department of Radiation Oncology, Boston, Massachusetts 02114, USA. jain@steele.mgh.harvard.edu
Booth
Michael F
MF
D000818:Animals; D002465:Cell Movement; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology; D051379:Mice; D009374:Neoplasms, Experimental / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000209:etiology*; D020286:Pericytes / Q000502:physiology*; D020574:Proto-Oncogene Proteins c-sis / Q000502:physiology*; D020797:Receptor, Platelet-Derived Growth Factor beta / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
D020574:Proto-Oncogene Proteins c-sis; D042461:Vascular Endothelial Growth Factor A; D020797:Receptor, Platelet-Derived Growth Factor beta