title: Scientific basis for the development of biokinetic models for radionuclide-contaminated wounds.
abstract: Radionuclide-contaminated wounds are of radiological concern because the wound provides a portal of entry of the radionuclide to the systemic circulation, and can also be a tissue at risk if sufficient dose is deposited at the wound site. Accordingly, a scientific committee established jointly by the US National Council on Radiation Protection and the International Commission on Radiological Protection has been developing an approach to describing the biokinetics of radionuclides deposited in wounds and calculating dose to the wound site. This paper focuses on the analyses, performed principally using experimental animal data, that have led to the development of a biokinetic model for deposited soluble radionuclides as well as more insoluble forms, such as colloids, particles and fragments. The available data for injected soluble materials have provided a basis for categorising 48 different elements (from Be to Cm and representing all of the chemical groups, except halogens and noble gases) into four distinct retention groups. In general, the data are adequate for developing a mechanistically based biokinetic model, whose application is exemplified for soluble radionuclides.
authors.affiliation: Los Alamos National Laboratory, MS-E546, HSR-12, Los Alamos, NM 87545, USA. rguilmette@lanl.gov
authors.forename: R A
authors.initials: RA
authors.lastname: Guilmette
authors.forename: P W
authors.initials: PW
authors.lastname: Durbin
mesh_terms: D000818:Animals; D003198:Computer Simulation; D007273:Injections, Intramuscular; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D018482:Muscle, Skeletal / Q000293:injuries* / Q000378:metabolism*; D011829:Radiation Dosage; D011868:Radioisotopes / Q000008:administration & dosage / Q000145:classification* / Q000493:pharmacokinetics*; D011874:Radiometry / Q000379:methods*; D018570:Risk Assessment / Q000379:methods; D014950:Wounds, Penetrating / Q000378:metabolism*
chemical_list: D011868:Radioisotopes