Stannylation approach to the synthesis of 2'- and 3'-substituted analogues of 2',3'-didehydro-2',3'-dideoxynucleosides.
Three methods are described for the introduction of a tributylstannyl group to the sp2-carbon of 2',3'-didehydro-2',3'-dideoxy nucleosides (d44Ns). The resulting stannylated products serve as versatile intermediates for the synthesis of d4Ns having various types of carbon-substituent.
Kumamoto
Hiroki
H
School of Pharmaceutical Sciences, Showa University, Shinagawa-ku, Tokyo, Japan.
Onuma
Sayoko
S
Tanaka
Hiromichi
H
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D015195:Drug Design; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D014220:Trialkyltin Compounds
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D007202:Indicators and Reagents; D014220:Trialkyltin Compounds; C011559:tributyltin