Synthesis of new chiral monodentate phosphite ligands and their use in catalytic asymmetric hydrogenation.
[reaction: see text] New monodentate phosphite ligands have been developed from axially chiral biphenols, which show excellent enantioselectivity in the Rh(I)-catalyzed hydrogenation of dimethyl itaconate. The new chiral ligand system is suitable to create libraries and possesses fine-tuning capability.
Hua
Zihao
Z
Department of Chemistry, State University of New York at Stony Brook, Stony Brook, New York 11794-3400, USA.
Vassar
Victor C
VC
Ojima
Iwao
I
D002384:Catalysis; D006865:Hydrogenation; D008024:Ligands; D008956:Models, Chemical; D015394:Molecular Structure; D017905:Phosphites / Q000138:chemical synthesis* / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism
D008024:Ligands; D017905:Phosphites; D012238:Rhodium