Results of liver transplantation according to indications for orthotopic liver transplantation.
OBJECTIVE
This study assessed the results of liver transplantation in patients with a variety of different indications.


METHODS
From 1989 to April 2003, 209 orthotopic liver transplantations (OLTx) were performed on 196 patients, including 178 cases. The diagnoses were: PBC (n = 34); PSC (n = 13); elective postinflammatory cirrhosis in the course of hepatitis C (n = 29); hepatitis B (n = 16); postalcoholic cirrhosis (n = 23), autoimmune cirrhosis (n = 11); Wilson's disease (n = 6); cirrhosis of unknown etiology (n = 10); secondary biliary cirrhosis (n = 5); Budd-Chiari syndrome (n = 6); and benign liver neoplasms (n = 7).


RESULTS
The 3-year survival rate in the group of patients transplanted electively was 74.1%. In other groups it was: PBC, 91.4%; PSC, 69.2%; hepatitis C, 69.6%; hepatitis B, 55.5%; postalcoholic cirrhosis, 80%; autoimmune cirrhosis, 81.8%; Wilson's disease, 57.1%; secondary biliary cirrhosis, 40%; Budd-Chiari syndrome, 66.6%; hemochromatosis, 100%; benign neoplasms of the liver, 87.5%; and liver cysts, 100%.


CONCLUSIONS
Results of liver transplantation were closely related to the urgency of the procedure. Better results were achieved in patients operated upon routinely compared with in those operated upon emergently (74.1% vs 50%). The best results of liver transplantation were achieved in patients transplanted on a routine basis with a diagnosis of PBC (91.4%), autoimmunologic cirrhosis (81.1%), postalcoholic cirrhosis (80%), or hemochoromatosis (100%). Patients with liver insufficiency due to hepatitis B and Wilson's disease have an increased risk of graft destruction, and the rate of survival in these patients is significantly lower than in other patients.
Nyckowski
P
P
Department of General, Transplantation, and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
Dudek
K
K
Skwarek
A
A
Zieniewicz
K
K
Pawlak
J
J
Patkowski
W
W
Michałowicz
B
B
Alsharabi
A
A
Wróblewski
T
T
Leowska
E
E
Paczkowska
A
A
Ołdakowska-Jedynak
U
U
Paczek
L
L
Krawczyk
M
M
D005260:Female; D006084:Graft Rejection / Q000188:drug therapy / Q000453:epidemiology; D049669:History, 16th Century; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008107:Liver Diseases / Q000145:classification / Q000601:surgery*; D016031:Liver Transplantation / Q000401:mortality / Q000706:statistics & numerical data*; D008297:Male; D018579:Patient Selection; D012189:Retrospective Studies; D012720:Severity of Illness Index; D015996:Survival Rate; D013997:Time Factors
D007166:Immunosuppressive Agents