title: Host range of chlamydiaphages phiCPAR39 and Chp3.
abstract: The host range of phiCPAR39 is limited to four Chlamydophila species: C. abortus, C. caviae, C. pecorum, and C. pneumoniae. Chp3 (a newly discovered bacteriophage isolated from C. pecorum) shares three of these hosts (C. abortus, C. caviae, and C. pecorum) but can additionally infect Chlamydophila felis. The ability to support replication was directly correlated with the binding properties of the respective bacteriophages with their host species. Binding studies also show that phiCPAR39 and Chp3 use different host receptors to infect the same host cells: cell binding is sensitive to proteinase K treatment, confirming that the chlamydiaphage receptors are proteinaceous in nature.
authors.affiliation: Molecular Microbiology and Infection, University Medical School, Southampton General Hospital, Southampton, SO16 6YD, United Kingdom.
authors.forename: J S
authors.initials: JS
authors.lastname: Everson
authors.forename: S A
authors.initials: SA
authors.lastname: Garner
authors.forename: P R
authors.initials: PR
authors.lastname: Lambden
authors.forename: B A
authors.initials: BA
authors.lastname: Fane
authors.forename: I N
authors.initials: IN
authors.lastname: Clarke
mesh_terms: D001435:Bacteriophages / Q000302:isolation & purification / Q000502:physiology*; D023501:Chlamydophila / Q000821:virology*; D019286:Endopeptidase K / Q000494:pharmacology; D011991:Receptors, Virus / Q000187:drug effects; D013045:Species Specificity; D014779:Virus Replication
chemical_list: D011991:Receptors, Virus; D019286:Endopeptidase K