Plasma lipid and lipoprotein concentrations in pregnancy induced hypertension.
OBJECTIVE
Aim of this study was to evaluate implication of pregnancy induced hypertension on maternal plasma lipid, lipoprotein, apolipoprotein concentrations and lipid peroxidation products by a comparison of normal pregnancy vs. preeclampsia.


METHODS
Thirty-four women with preeclampsia and 32 healthy pregnant women (controls) in the third trimester were recruited for this study.


RESULTS
In the preeclamptic group plasma total triglyceride, low density lipoprotein cholesterol (LDL-C), malondialdehyde (MDA) and apolipoprotein B (apo-B) were significantly increased, while plasma high density lipoprotein cholesterol (HDL-C) was significantly decreased compared to that of control group. There was no significant difference in total cholesterol and apolipoprotein A1 (apo-A1) concentrations.


CONCLUSIONS
Our findings suggest that preeclampsia share some metabolic characteristics with coronary artery disease such as dislipidemia and increased lipid peroxidation. However lipoprotein concentrations may be better biochemical markers of dislipidemia in the preeclamptic state than the corresponding apolipoproteins.
Cekmen
Mustafa Baki
MB
Kocaeli University, Medical Faculty, Department of Biochemistry, Kocaeli, Turkey. mustafacekmen@hotmail.com
Erbagci
Ayse Binnur
AB
Balat
Ayse
A
Duman
Can
C
Maral
Hale
H
Ergen
Kivanc
K
Ozden
Meltem
M
Balat
Ozcan
O
Kuskay
Sevinc
S
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy
D008055:Lipids; D008074:Lipoproteins; D008315:Malondialdehyde