Sensory neurons from mice lacking the Brn-3b POU family transcription factor are resistant to death-inducing stimuli both in vitro and in vivo.
The critical role for programmed cell death in the normal development of the nervous system and the abnormal cell death that occurs in human neurodegenerative diseases renders it of vital importance to identify factors that enhance or reduce the levels of cell death in specific neuronal cells in the nervous system. We show that the Brn-3b transcription factor is essential for normal cell death responses in the peripheral nervous system and that in its absence neurons are resistant to a variety of death-inducing stimuli both in vitro and in vivo.
Ensor
Elizabeth
E
Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.
Mathews
Karen
K
Payne Smith
Martin D
MD
Latchman
David S
DS
D000818:Animals; D000831:Animals, Newborn; D019208:Brain-Derived Neurotrophic Factor / Q000494:pharmacology; D002166:Camptothecin / Q000494:pharmacology; D002352:Carrier Proteins / Q000378:metabolism; D002452:Cell Count; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D016373:DNA, Antisense / Q000494:pharmacology; D004268:DNA-Binding Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D004347:Drug Interactions; D004351:Drug Resistance; D004791:Enzyme Inhibitors / Q000494:pharmacology; D017950:Ganglia, Sensory / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D006579:Heterozygote; D006801:Humans; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D008562:Membrane Glycoproteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D020932:Nerve Growth Factor / Q000494:pharmacology; D009475:Neurons, Afferent / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases; D020917:Receptor, trkA; D020812:Receptor, trkC / Q000378:metabolism; D020426:Sciatic Neuropathy / Q000378:metabolism; D019311:Staurosporine / Q000494:pharmacology; D013997:Time Factors; D050819:Transcription Factor Brn-3A; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D020813:Receptor, trkB
D019208:Brain-Derived Neurotrophic Factor; D002166:Camptothecin; D002352:Carrier Proteins; D016373:DNA, Antisense; D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D020932:Nerve Growth Factor; D011505:Protein-Tyrosine Kinases; D020917:Receptor, trkA; D020812:Receptor, trkC; D019311:Staurosporine; D050819:Transcription Factor Brn-3A; D014157:Transcription Factors; C494188:POU4F1 protein, human; C064371:Ntrk2 protein, mouse; D020813:Receptor, trkB