Comparison of absorption after inhalation and instillation of uranium octoxide.
Values for the absorption parameters were compared after inhalation or intratracheal instillation of 1.5 microm mass median aerodynamic diameter (MMAD) 233U3O8 particles into the lungs of HMT strain rats. The two sets of parameter values were similar, as were the calculated dose coefficients and predicted biokinetics for workers. Hence the inhalation and instillation techniques can probably both be used to generate values of the absorption parameters for U3O8.
Pellow
P G D
PG
National Radiological Protection Board, Chilton, Didcot, Oxon OX11 0RQ, UK. peter.pellow@nrpb.org
Hodgson
S A
SA
Hodgson
A
A
Rance
E
E
Ellender
M
M
Guilmette
R A
RA
Stradling
G N
GN
D000042:Absorption; D000280:Administration, Inhalation; D000396:Air Pollutants, Radioactive / Q000493:pharmacokinetics / Q000652:urine; D000818:Animals; D003198:Computer Simulation; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis; D007275:Injections, Intravenous; D008168:Lung / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D010087:Oxides / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000652:urine; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D051381:Rats; D017974:Uranium Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000652:urine
D000396:Air Pollutants, Radioactive; D010087:Oxides; D017974:Uranium Compounds; C054287:uranium octoxide