title: Design and total synthesis of a superior family of epothilone analogues, which eliminate xenograft tumors to a nonrelapsable state.
authors.affiliation: Preclinical Pharmacology Core Facility, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10021, USA.
authors.forename: Ting-Chao
authors.initials: TC
authors.lastname: Chou
authors.forename: Huajin
authors.initials: H
authors.lastname: Dong
authors.forename: Alexey
authors.initials: A
authors.lastname: Rivkin
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yoshimura
authors.forename: Ana E
authors.initials: AE
authors.lastname: Gabarda
authors.forename: Young Shin
authors.initials: YS
authors.lastname: Cho
authors.forename: William P
authors.initials: WP
authors.lastname: Tong
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Danishefsky
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D001835:Body Weight; D004354:Drug Screening Assays, Antitumor; D034261:Epothilones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008956:Models, Chemical; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D017239:Paclitaxel / Q000494:pharmacology / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D034261:Epothilones; D017239:Paclitaxel