[Updates in osteogenesis imperfecta].
Osteogenesis Imperfecta, a heterogenous group of inherited disorders, is characterized by both bone fragility and low bone mass. Since the Sillence classification of the disease, significant progress has been made in understanding the molecular, histological and genetical pathogenesis of the disease, and it led to expanded nosology. The multidisciplinary approach including rehabilitation, medications and surgery, may significantly improve the quality of life and prolong life expectancy.
Zeitlin
Leonid
L
Departments of Pediatric Orthopaedics, Dana Children's Hospital, Israel.
Wientroub
Shlomo
S
Blumberg
Nehemia
N
D006801:Humans; D008017:Life Expectancy; D010013:Osteogenesis Imperfecta / Q000145:classification* / Q000401:mortality / Q000534:rehabilitation / Q000628:therapy*; D010348:Patient Care Team; D011788:Quality of Life