The uterine length in women with Turner syndrome reflects the postmenarcheal daily estrogen dose.
OBJECTIVE
To evaluate the effects of estrogen substitution on the uterine development in patients with Turner syndrome.


METHODS
57 women, aged 18.1-41.5 years, were treated with estrogen from puberty induction.


RESULTS
In 21 women (37%), the uterus developed to >65 mm in length. The daily estrogen dose correlated with both uterine length (r = 0.29; p < 0.05) and Tanner breast stage (r = 0.44; p < 0.001). A negative correlation between age at artificial menarche and uterine length was found (r = -0.29; p < 0.05). The endometrium thickness was greater in women with an uterus length >65 mm (p < 0.05). In 50% of the women (18 were evaluated), an adult-shaped uterus developed. Previous growth hormone therapy (n = 32) had no impact on the uterus length.


CONCLUSIONS
The uterine development was suboptimal in most patients. Further investigation is needed to optimize estrogen therapy for uterine development in patients with Turner syndrome.
Snajderova
Marta
M
Endocrine Unit, 2nd Department of Paediatrics, 2nd Faculty of Medicine, University Hospital Motol, Prague, Czech Republic. marta.snajderova@lfmotol.cuni.cz
Mardesic
Tonko
T
Lebl
Jan
J
Gerzova
Hedvika
H
Teslik
Leos
L
Zapletalova
Jirina
J
D000293:Adolescent; D000328:Adult; D001940:Breast / Q000187:drug effects / Q000254:growth & development; D003430:Cross-Sectional Studies; D036861:Delivery, Obstetric; D004305:Dose-Response Relationship, Drug; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008572:Menarche; D011247:Pregnancy; D014424:Turner Syndrome / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000503:physiopathology; D014463:Ultrasonography; D014599:Uterus / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000254:growth & development
D004967:Estrogens