Effects of sevoflurane compared with those of isoflurane on arterial oxygenation and hemodynamics during one-lung ventilation.
OBJECTIVE
This study was designed to compare the effects of sevoflurane and isoflurane on Pao(2) and hemodynamic variables during one-lung ventilation (OLV) in surgical patients.


METHODS
Twelve patients undergoing an esophageal procedure with thoracotomy for which a long period of OLV was required were studied using a randomized crossover design. Group 1 received 1.2% isoflurane from the induction of anesthesia until 30 min after starting OLV, and then received 1.7% sevoflurane during the remaining period. In group 2, the order of the anesthetics was reversed. All experimental procedures were performed in the left lateral decubitus position with the chest opened. Arterial and mixed venous blood gases and cardiac outputs were analyzed immediately before OLV, during OLV, and after resumption of two-lung ventilation (TLV).


RESULTS
OLV produced lower PaO(2) and higher venous admixture (Q(s)/Q(t)) values than TLV. However, there was no significant difference between sevoflurane and isoflurane in PaO(2) or Q(s)/Q(t) during OLV. Other hemodynamic variables except for PVO(2) showed no significant differences between the anesthetics.


CONCLUSIONS
The effects of sevoflurane on PaO(2) and the hemodynamic variables were similar to those of isoflurane during TLV and OLV in the lateral decubitus position.
Saito
M
M
Department of Anesthesiology, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Cho
S
S
Morooka
H
H
Hasuo
H
H
Shibata
O
O
Sumikawa
K
K