title: Self-aggregation behavior of alkylated chitosan and its effect on the release of a hydrophobic drug.
abstract: Chitosan (CS) was hydrophobically modified with butyl bromide and dodecyl bromide. The self-aggregation in acetic acid solution was characterized by fluorescence spectroscopy and dynamic light-scattering method. The results indicate that introducing butyl and dodecyl moieties leads to the formation of self-aggregates. Along with the enhancement in the hydrophobicity of chitosan the self-association occurs at a lower concentration, and the mean size of self-aggregates increases. The loading capacity of butylated chitosan (4-CS) and dodecylated chitosan (12-CS) for vitamin B2 are markedly increased compared to that of chitosan, and the release of drug from alkylated chitosans is somewhat hindered due to its increased affinity for hydrophobic carriers.
authors.affiliation: Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072, PR China. wgliu@tju.edu.cn
authors.forename: Wenguang
authors.initials: W
authors.lastname: Liu
authors.forename: Shu Jun
authors.initials: SJ
authors.lastname: Sun
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Kang De
authors.initials: KD
authors.lastname: Yao
mesh_terms: D000478:Alkylation; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry*; D048271:Chitosan; D004337:Drug Carriers / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D010539:Permeability; D011721:Pyrenes; D012256:Riboflavin / Q000737:chemistry* / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
chemical_list: D004337:Drug Carriers; D011721:Pyrenes; D002686:Chitin; D048271:Chitosan; C030984:pyrene; D012256:Riboflavin