title: Synthesis, stability, and biological evaluation of 1,3-dihydrobenzo[c]furan analogue of d4T and its SATE pronucleotide.
abstract: The anti-HIV activity and stability studies of 1,3-dihydrobenzo[c]furan analogue of d4T are reported. The corresponding mononucleoside phosphotriester derivative bearing a S-pivaloyl-2-thioethyl (tBuSATE) group, as biolabile phosphate protection, is also studied.
authors.affiliation: Laboratoire des Glucides, Université de Picardie-Jules Verne, Amiens, France. christophe.len@sc.u-picardie.fr
authors.forename: Christophe
authors.initials: C
authors.lastname: Len
authors.forename: Abdelmajid
authors.initials: A
authors.lastname: Selouane
authors.forename: Denis
authors.initials: D
authors.lastname: Postel
authors.forename: Pierre
authors.initials: P
authors.lastname: Villa
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Aubertin
authors.forename: David
authors.initials: D
authors.lastname: Egron
authors.forename: Gilles
authors.initials: G
authors.lastname: Gosselin
authors.forename: Christian
authors.initials: C
authors.lastname: Périgaud
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001572:Benzofurans; D002460:Cell Line; D004355:Drug Stability; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology*; D006207:Half-Life; D006801:Humans; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018119:Stavudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013237:Stereoisomerism; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D001572:Benzofurans; D011355:Prodrugs; D018119:Stavudine