A novel PNA-monomer for recognition of thymine in triple-helix structures.
To expand the triplex recognition repertoire of Nucleic Acids, novel nucleobases that recognize thymine in a T-A base pair are still required. A novel conformationally constrained PNA-monomer (II) capable of binding T in a triplex motif was designed and synthesized in 7 steps starting from commercially available dimethyl 2-oxoglutarate.
Olsen
Anne Goldbech
AG
Department of Chemistry, University of Copenhagen, Copenhagen O, Denmark. ago@kiku.edu
Dahl
Otto
O
Nielsen
Peter E
PE
D020029:Base Pairing; D001665:Binding Sites; D009690:Nucleic Acid Conformation; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis*; D013941:Thymine
D020135:Peptide Nucleic Acids; D013941:Thymine