Synthesis of 2'-deuterio and 3'-deuterio cytidine 5'-diphosphate.
2'-2H- and 3'-2H-CDP were synthesized from 5'-MMT-3'-O-TBDMS and 2',5'-O-diTBDMS cytidine derivatives, respectively, by oxidation followed by acidic removal of 5'-protection, reduction with [NaBD(OAc)3] and finally displacement of a tosyl group by pyrophosphate.
Sandbrink
Jessica
J
Division of Organic and Bioorganic Chemistry, MBB Scheele Laboratory, Karolinska Institute, Stockholm, Sweden.
Strömberg
Roger
R
D003565:Cytidine Diphosphate / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D003903:Deuterium; D004578:Electron Spin Resonance Spectroscopy; D007202:Indicators and Reagents; D007553:Isotope Labeling / Q000379:methods
D007202:Indicators and Reagents; D003565:Cytidine Diphosphate; D003903:Deuterium