title: [The new agent G-1724: synthesis and test on murine models of trichuriasis and trichinosis].
abstract: To search for new antihelminthics, the new compound N-[3-chloro-4-[(1-ethyl-2-benzimidazolyl) thio]phenyl]-2-hydroxy-3,5-dibromobenzamide (the agent G-1724) was synthesized and tested by using the models of trichocephaliasis (Trichocephalus muris) and trichinosis (Trichinella spiralis). The tests demonstrated that this agent had an nematocidal effect (71-78%).
authors.forename: N A
authors.initials: NA
authors.lastname: Dobrovinskaia
authors.forename: S N
authors.initials: SN
authors.lastname: Trusov
authors.forename: L V
authors.initials: LV
authors.lastname: Fedianina
authors.forename: N L
authors.initials: NL
authors.lastname: Veretennikova
authors.forename: D P
authors.initials: DP
authors.lastname: Sevbo
authors.forename: F S
authors.initials: FS
authors.lastname: Mikhaĭlitsyn
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000969:Antinematodal Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000627:therapeutic use*; D001549:Benzamides / Q000008:administration & dosage / Q000138:chemical synthesis / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000138:chemical synthesis / Q000627:therapeutic use*; D004195:Disease Models, Animal; D051379:Mice; D017160:Trichinella spiralis; D014235:Trichinellosis / Q000188:drug therapy* / Q000469:parasitology; D014257:Trichuriasis / Q000188:drug therapy* / Q000469:parasitology; D014258:Trichuris
chemical_list: D000969:Antinematodal Agents; D001549:Benzamides; D001562:Benzimidazoles; C480821:N-(3-chloro-4-((1-ethyl-2-benzimidazolyl)thio)phenyl)-2-hydroxy-3,5-dibromobenzamide