title: Successful intrauterine treatment of cystic hygroma colli using OK-432. A case report.
abstract: A 36-year-old multiparous woman was referred at 25 weeks of gestation with suspected cystic hygroma. Ultrasonographic examination demonstrated large multiple cysts around the fetal neck. We treated them by injection of OK-432 at 29 and 32 weeks of gestation. The cysts decreased in size after the intrauterine treatment. A female baby was delivered at 38 weeks of gestation. She was healthy, and there was only a small swelling of the skin in the nuchal area at birth. One month later, the slight swelling of the skin had completely disappeared. Intrauterine injection of OK-432 was a safe and effective therapy for fetal cystic hygroma.
authors.affiliation: Department of Perinatology, National Cardiovascular Center, Osaka, Japan.
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Chiba
mesh_terms: D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D015552:Injections, Intralesional; D018191:Lymphangioma, Cystic / Q000000981:diagnostic imaging / Q000188:drug therapy*; D010844:Picibanil / Q000008:administration & dosage* / Q000627:therapeutic use; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods; D016216:Ultrasonography, Prenatal / Q000379:methods*
chemical_list: D010844:Picibanil