title: Delayed and bilateral changes of GAP-43/B-50 phosphorylation after circling training during a critical period in rat striatum.
abstract: During the critical period of activity-dependent plasticity in rat striatum (30-37 days after birth) physiological circling behavior induces delayed modifications in GAP-43/B-50 phosphorylation by PKC. Postexercise, ipsi- and contralateral striatum to the circling direction show a similar temporal pattern of GAP-43/B-50 phosphorylation, with an initial decrease followed by a subsequent increase. However, there is a lag between initiation of the phosphorylation response in this asymmetrical task which does not occur when animals are subjected to exercise under conditions of symmetrical motor activity.
authors.affiliation: Laboratorio de Biología Celular, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, 4th Piso, Pabellón II, Ciudad Universitaria (C1428EHA), Buenos Aires, Argentina. azcuipon@bg.fcen.uba.ar
authors.forename: Julio M
authors.initials: JM
authors.lastname: Azcurra
authors.forename: Mariano
authors.initials: M
authors.lastname: Soiza-Reilly
authors.forename: Mariana
authors.initials: M
authors.lastname: Fossati
authors.forename: Gustavo Ch
authors.initials: GCh
authors.lastname: Paratcha
mesh_terms: D000818:Animals; D007839:Functional Laterality / Q000502:physiology; D019922:GAP-43 Protein / Q000378:metabolism*; D007858:Learning / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D017072:Neostriatum / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D010766:Phosphorylation; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000502:physiology
chemical_list: D019922:GAP-43 Protein