Higher content of 18:1 trans fatty acids in subcutaneous fat of persons with coronarographically documented atherosclerosis of the coronary arteries.
OBJECTIVE
To identify the total content of trans fatty acid (TFA) isomers and C18:1 trans isomers in subcutaneous fat samples from persons with atherosclerosis of the coronary arteries, as an indicator of dietary exposure.


METHODS
Using capillary gas chromatography, the authors determined total content of TFA isomers and C18:1 trans isomers in the subcutaneous fat of 34 patients with ischemic heart disease who had undergone aortocoronary bypass surgery and in 46 patients with no sign of coronary disease.


RESULTS
On average, the total TFAs in cardiac patients were 2.88 +/- 1.19% of all fatty acids, in noncardiac patients 2.56 +/- 0.89%. However, the difference is not statistically significant. The average concentration of C18:1 trans in cardiac patients (2.31 +/- 1.09%) was statistically significantly higher (p = 0.05) than in the noncardiac group (1.95 +/- 0.77%).


CONCLUSIONS
The results obtained indicate a lower TFA load in comparison with previous studies in other countries. A higher concentration of 18:1 TFAs in the subcutaneous fat of patients with coronary disease might be an impulse to correct the dietary habits of this very high-risk population.
Dlouhý
P
P
Division of Nutrition, 3rd Faculty of Medicine, Charles University, Ruská 87, CZ-100.00 Prague 10, Czech Republic. Pavel.Dlouhy@lf3.cuni.cz
Tvrzická
E
E
Stanková
B
B
Vecka
M
M
Zák
A
A
Straka
Z
Z
Fanta
J
J
Pachl
J
J
Kubisová
D
D
Rambousková
J
J
Bílková
D
D
Andel
M
M
D000273:Adipose Tissue / Q000737:chemistry*; D016022:Case-Control Studies; D002849:Chromatography, Gas; D003324:Coronary Artery Disease / Q000378:metabolism*; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007536:Isomerism; D008297:Male; D008875:Middle Aged; D044242:Trans Fatty Acids / Q000032:analysis*
D004042:Dietary Fats, Unsaturated; D044242:Trans Fatty Acids