A cylindrical model for studying subendocardial ischaemia in the left ventricle.
In this paper a mathematical model of a left ventricle with a cylindrical geometry is presented with the aim of gaining a better understanding of the relationship between subendocardial ischaemia and ST depression. The model is formulated as an infinite cylinder and takes into account the full bidomain nature of cardiac tissue, as well as fibre rotation. A detailed solution method (based on Fourier series, Fourier transforms and a one dimensional finite difference scheme) for the governing equations for electric potential in the tissue and the blood is also presented. The model presented is used to study the effect increasing subendocardial ischaemia has on the epicardial potential distribution as well as the effects of changing the bidomain conductivity values. The epicardial potential distributions obtained with this cylindrical geometry are compared with results obtained using a previously published slab model. Results of the simulations presented show that the morphologies of the epicardial potential distributions are similar between the two geometries, with the main difference being that the cylindrical model predicts slightly higher potentials.
Johnston
Peter R
PR
School of Science, Griffith University, Nathan, 4111, Queensland, Australia. p.johnston@griffith.edu.au
D000200:Action Potentials; D003198:Computer Simulation; D006329:Heart Conduction System; D006352:Heart Ventricles / Q000033:anatomy & histology; D006801:Humans; D008955:Models, Cardiovascular; D017202:Myocardial Ischemia