title: [Study on the effect of NaFeEDTA on preventing lead poisoning in rats and its impact on zinc, copper].
abstract: In order to explore the effect of sodium iron ethylenediaminetetraacetate (NaFeEDTA) on preventing rats from lead poisoning and reducing the lead toxicity, and at the same time to explore its impact on zinc and copper, sixty Wistar rats were randomly divided into six groups including blank control group, model control group, positive control group and three different level NaFeEDTA (high, middle and low) groups. With the exception of the blank control group, which only received double distilled water treatment throughout the experiment, all the other rats were continuously treated with lead solution. At the same time, with the exception of the blank and model control groups, the other four groups were treated with acidi dimercaptosuccinici (DMSA), high, middle and low level NaFeEDTA solutions respectively. At the end of the study, several indicators were determined. The results showed that the hemoglobin levels in the three different level NaFeEDTA groups were significantly higher than those of the other four groups and at the same time the lead levels in blood and organs were lower than those of model group significantly. There were significant reverse correlations between iron supplement and the lead levels in liver, kidney and tibia among the three different level NaFeEDTA groups, and the correlation coefficients were -0.4432, -0.6134 and -0.3878 respectively. There were no significant differences in zinc levels and copper levels between the three level NaFeEDTA groups and the negative control group except the brain zinc levels in the middle and high level NaFeEDTA groups were lower and the kidney copper level in the low level NaFeEDTA group was higher than those of the model control group. It is concluded that the NaFeEDTA can effectively improve hemoglobin level, prevent rats from lead poisoning and reduce the lead toxicity. At the same time, NaFeEDTA does not have significant influence on zinc and copper levels in rats.
authors.affiliation: Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Junquan
authors.initials: J
authors.lastname: Gao
authors.forename: Jingling
authors.initials: J
authors.lastname: Zhao
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D003300:Copper / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004492:Edetic Acid / Q000494:pharmacology*; D005290:Ferric Compounds / Q000494:pharmacology*; D006454:Hemoglobins / Q000187:drug effects; D007855:Lead Poisoning / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000378:metabolism*
chemical_list: D005290:Ferric Compounds; D006454:Hemoglobins; D003300:Copper; D004492:Edetic Acid; D015032:Zinc; C019179:Fe(III)-EDTA