title: The bold legacy of Emil Fischer.
abstract: A century has passed since Emil Fischer won the Nobel Prize in chemistry. From his first synthesis of glycyl-glycine in 1901 he has been a luminary to peptide chemists over the past 100 years. In this paper, a brief summary of some of the major accomplishments in peptide chemistry will be covered followed by a description of several of our own endeavours in peptide chemistry which arose from the discoveries of the giants of our field. We will include the development of a novel activating agent (DEPBT), the synthesis of a novel building block, alpha-methyl-D-cysteine, its incorporation into biologically active opioids, and conclude with the synthesis of dendritic collagen mimetics.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0343, USA. mgoodman@ucsd.edu
authors.forename: Murray
authors.initials: M
authors.lastname: Goodman
authors.forename: Weibo
authors.initials: W
authors.lastname: Cai
authors.forename: Nicole D
authors.initials: ND
authors.lastname: Smith
mesh_terms: D003094:Collagen / Q000737:chemistry; D049673:History, 20th Century; D049674:History, 21st Century; D018716:Molecular Mimicry; D015394:Molecular Structure; D009613:Nobel Prize; D018847:Opioid Peptides / Q000737:chemistry; D010755:Organophosphates / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000266:history*; D014227:Triazines / Q000737:chemistry
chemical_list: C410327:3-(diethoxyphosphoryloxy)-1,2,3-benzotriazin-4(3H)-one; D018847:Opioid Peptides; D010755:Organophosphates; D010455:Peptides; D014227:Triazines; D003094:Collagen