The use of triisopropylsilyl-oxymethyl (TOM) in the synthesis of anti-telomerase 2-5A antisense compound RBI 011.
The 2-5A antisense compound RBI 011 targeting telomerase RNA was synthesized using the triisopropylsilyl-oxymethyl (TOM) group for the 3'-hydroxyl protection of 2',5'-linked RNA.
Cramer
Hagen
H
Ridgeway Biosystems Inc., Cleveland, Ohio, USA.
Rhea
Rachele
R
Okicki
Jim
J
Yirava
Karen
K
Silverman
Robert
R
D015088:2',5'-Oligoadenylate Synthetase / Q000037:antagonists & inhibitors; D002678:Chimera; D004247:DNA / Q000737:chemistry; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides / Q000138:chemical synthesis*; D010766:Phosphorylation; D016372:RNA, Antisense / Q000138:chemical synthesis*; D012091:Repetitive Sequences, Nucleic Acid; D019098:Telomerase / Q000037:antagonists & inhibitors / Q000235:genetics*
D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; C479443:RBI 011; D016372:RNA, Antisense; D004247:DNA; D019098:Telomerase; D015088:2',5'-Oligoadenylate Synthetase