Gilbert's syndrome as a predisposing factor for idiopathic cholelithiasis in children.
The frequency of the (TA)7/(TA)7 promoter genotype of UDP-glucuronosyltransferase gene (UGT1A1) was significantly higher (p<0.05) in a group of 30 children with cholelithiasis than in a control group of 40 healthy children, indicating that this genotype might be an underlying factor for gallstone initiation in otherwise healthy children.
Kitsiou-Tzeli
Sofia
S
Kanavakis
Emmanuel
E
Tzetis
Maria
M
Kavazarakis
Emmanuel
E
Galla
Angeliki
A
Tsezou
Aspasia
A
D002648:Child; D002769:Cholelithiasis / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D005838:Genotype; D005878:Gilbert Disease / Q000201:enzymology / Q000235:genetics*; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D017720:Molecular Epidemiology; D013577:Syndrome; D000099148:UGT1A1 Enzyme
D014453:Glucuronosyltransferase; D000099148:UGT1A1 Enzyme