title: P(i-BuNCH2CH2)3N: an efficient ligand for the direct alpha-arylation of nitriles with aryl bromides.
abstract: A new catalyst system for the synthesis of alpha-aryl-substituted nitriles is reported. The bicyclic triaminophosphine P(i-BuNCH(2)CH(2))(3)N (1b) serves as an efficient and versatile ligand for the palladium-catalyzed direct alpha-arylation of nitriles with aryl bromides. Using ligand 1b, ethyl cyanoacetate and primary as well as secondary nitriles are efficiently coupled with a wide variety of aryl bromides possessing electron-rich, electron-poor, electron-neutral, and sterically hindered groups.
authors.affiliation: Department of Chemistry, Gilman Hall, Iowa State University, Ames, Iowa 50011, USA.
authors.forename: Jingsong
authors.initials: J
authors.lastname: You
authors.forename: John G
authors.initials: JG
authors.lastname: Verkade