[Enhancing the cytotoxicity of antitumor drugs through electromagnetic pulses].
We chose Hela cells as research object and studied the cytotoxicity generated by cyclophosphamide, an antitumor drug, after cell electroporation by the use of electromagnetic pulses. Comparison between the electroporation group and the contrast group revealed the greatly enhanced cytotoxicity of the electroporation group, indicating that under some conditions electromagnetic pulses can enhance the cytotoxicity of antitumor drugs. The results of this study provide reliable evidences and a feasible approach for clinical treatment of tumor.
Yang
Guo
G
Department of Radio Electronics, Sichuan University, Chengdu 610064.
Wang
Baoyi
B
Zhang
Hong
H
Chen
Haichuan
H
Wang
Zishu
Z
Yang
Kong
K
Sun
Jingru
J
D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D002470:Cell Survival / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D055590:Electromagnetic Phenomena; D018274:Electroporation / Q000379:methods*; D006367:HeLa Cells; D006801:Humans
D000970:Antineoplastic Agents; D003520:Cyclophosphamide