title: Loxapine versus olanzapine in the treatment of delirium following traumatic brain injury.
abstract: The use of typical neuroleptics has always been the mainstay of treatment for delirium following traumatic brain injury (TBI). Given the recent application of atypical neuroleptics to various psychiatric conditions formerly treated with typical neuroleptics, one questions whether this new class of drugs is superior to its predecessor in treating delirium post-TBI. We present a case of one patient with TBI-induced delirium where in fact the use of the typical mid-potency neuroleptic, loxapine, appeared to have a better clinical effect over the atypical neuroleptic, olanzapine.
authors.affiliation: University of Alberta Medical School, Edmonton, Alberta, Canada.
authors.forename: Deborah
authors.initials: D
authors.lastname: Krieger
authors.forename: Keith
authors.initials: K
authors.lastname: Hansen
authors.forename: Colleen
authors.initials: C
authors.lastname: McDermott
authors.forename: Roy
authors.initials: R
authors.lastname: Matthews
authors.forename: Rachel
authors.initials: R
authors.lastname: Mitchell
authors.forename: Natasha
authors.initials: N
authors.lastname: Bollegala
authors.forename: Shree
authors.initials: S
authors.lastname: Bhalerao
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines; D001930:Brain Injuries / Q000150:complications*; D003693:Delirium / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008152:Loxapine / Q000627:therapeutic use*; D008297:Male; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000627:therapeutic use*
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D008152:Loxapine; D000077152:Olanzapine