title: COMET: a proposed mechanism of action to explain the results and concerns about dose.
authors.forename: Ake
authors.initials: A
authors.lastname: Hjalmarson
authors.forename: Finn
authors.initials: F
authors.lastname: Waagstein
mesh_terms: D018674:Adrenergic Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology* / Q000627:therapeutic use*; D002227:Carbazoles / Q000494:pharmacology* / Q000627:therapeutic use*; D000077261:Carvedilol; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006333:Heart Failure / Q000188:drug therapy*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008790:Metoprolol / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use*; D011412:Propanolamines / Q000494:pharmacology* / Q000627:therapeutic use*; D012107:Research Design / Q000592:standards; D016896:Treatment Outcome
chemical_list: D018674:Adrenergic Antagonists; D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; D008790:Metoprolol