Ephective endocytosis.
Two important new reports identify endocytosis of EphB-ephrinB complexes as a mechanism for switching between cell-cell adhesion and repulsion following plasma membrane contact. Together with the previously described shedding of ephrinA following EphA engagement, these findings resolve the paradox of how an adhesive receptor-ligand interaction generates a repulsive cellular response.
Halford
Michael M
MM
Center for Developmental Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA.
Chumley
Michael J
MJ
Henkemeyer
Mark
M
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D004705:Endocytosis / Q000502:physiology*; D036387:Ephrin-B1 / Q000502:physiology*; D036081:Receptors, Eph Family / Q000502:physiology*
D036387:Ephrin-B1; D036081:Receptors, Eph Family