[Effect of buspirone on aggressive and anxiety behavior of male mice with various aggressive experience].
The effect of the 5-HT1A receptor agonist buspirone on the aggressive and anxious behavior of C57BL/6J male mice with different experience of aggression was studied. In the group of animals with short-time (3 days) winner experience, buspirone (1 mg/kg, i.p.) produced an anxiogenic effect (manifested in the plus-maze test) and reduced the level of aggression (agonist confrontation test). No such effects were observed in the group of animals with a long-time (20 days) aggression experience. It is suggested that the antiaggressive effect of buspirone in the former case is related to the anxiogenic action, while a long experience of aggression reduced the pharmacological sensitivity of 5-HT1A receptors to buspirone in the latter case.
Bondar'
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Department of Neurogenetics of Social Behavior, Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, pr. akad. Lavrent'eva, 10, Novosibirsk, 630090 Russia.
Kudriavtseva
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NN
D000374:Aggression; D000818:Animals; D001007:Anxiety / Q000523:psychology*; D002065:Buspirone / Q000494:pharmacology*; D003220:Conflict, Psychological; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D044282:Receptor, Serotonin, 5-HT1A / Q000187:drug effects*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D017366:Serotonin Receptor Agonists; D044282:Receptor, Serotonin, 5-HT1A; D002065:Buspirone