On-line clearance: a useful tool for monitoring the effectiveness of the reuse procedure.
Reprocessing of a dialyzer for repeated use in the same patient is widely practiced. The dialyzer fiber bundle volume (FBV) is monitored as an indicator of the dialyzer's suitability for continued use, with standards for reprocessed dialyzers requiring a FBV of greater than 80% of a new dialyzer to be maintained. We have used on-line measurement of clearance of sodium (OLC module, Fresenius Medical Care, Walnut Creek, CA) to assess small molecule clearance changes during and between treatments for a group of 29 chronic hemodialysis patients who reused high flux polysulfone dialyzers (F80, Fresenius Medical Care, Lexington, MA) reprocessed using citric acid and heat (95 degrees C). Data pertaining to the initial, 5th, 10th, and 15th uses were analyzed and showed that, within a single dialysis session, there was a trend for the clearance to reduce throughout the treatment (p < 0.001). Overall, there was also a trend for clearances to decline with increasing number of reuses (p < 0.008). Changes in FBV occurred, but such changes remained within the guidelines suggested by standards. It is concluded that on-line clearance measurements provide a simple noninvasive method to monitor dialyzer performance over each use and between uses.
Rahmati
Margaret A
MA
Division of Nephrology, Beth Israel Medical Center, New York, New York, USA.
Rahmati
Shahriar
S
Hoenich
Nicholas
N
Ronco
Claudio
C
Kaysen
George A
GA
Levin
Robert
R
Levin
Nathan W
NW
D000368:Aged; D001783:Blood Flow Velocity; D017743:Equipment Reuse; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D006435:Renal Dialysis / Q000379:methods*; D012964:Sodium / Q000378:metabolism
D012964:Sodium