title: Churg-Strauss syndrome with myocarditis manifesting as acute myocardial infarction with cardiogenic shock: case report and review of the literature.
abstract: A patient with a two-year history of worsening asthma presented with chest pain and shortness of breath. She developed cardiogenic shock. Analysis of blood chemistry detected increased troponin I concentration. Her electrocardiographic changes were consistent with a diagnosis of anteroseptal myocardial infarction. However, angiography showed normal coronary arteries. Left ventriculography showed severe mitral regurgitation and global hypokinesis. Peripheral eosinophilia was detected. Subsequent endomyocardial biopsy showed myocarditis with prominent eosinophil and plasma cell components. Churg-Strauss syndrome was diagnosed based on her history of asthma, evidence of peripheral eosinophilia and results of endomycardial biopsy. Treatment with a high dose of corticosteroids was initiated. As symptoms of heart failure improved - without recurrence of cardiac and respiratory symptoms - the dose of corticosteroids was gradually reduced. Eight months after her original presentation, she developed urticarial lesions on her abdomen and legs, with muscle soreness but no other associated symptoms. She was treated with a combination of prednisone and dapsone. After the diagnosis of Churg-Strauss syndrome, the patient remained symptom free with a normal ejection fraction for 15 months while taking prednisone.
authors.affiliation: miriamshanks@yahoo.com
authors.forename: Miriam
authors.initials: M
authors.lastname: Shanks
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Ignaszewski
authors.forename: Sammy Y
authors.initials: SY
authors.lastname: Chan
authors.forename: Michael F
authors.initials: MF
authors.lastname: Allard
mesh_terms: D000893:Anti-Inflammatory Agents; D001249:Asthma / Q000188:drug therapy / Q000453:epidemiology; D015267:Churg-Strauss Syndrome / Q000150:complications* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology*; D009205:Myocarditis / Q000453:epidemiology* / Q000209:etiology*; D011241:Prednisone / Q000627:therapeutic use; D012770:Shock, Cardiogenic / Q000209:etiology*
chemical_list: D000893:Anti-Inflammatory Agents; D011241:Prednisone