Deaza- and deoxyadenosine derivatives: synthesis and inhibition of animal viruses as human infection models.
N6-Cycloalkyl-2',3'-dideoxyadenosine derivatives and (2-chloro)-N6-cycloheptyl-3-deazaadenosine have been synthesized and tested, along with other (deaza)purine (deoxy)nucleosides from our chemical library, as inhibitors of virus replication against Bovine Herpes Virus 1 (BHV-1) and sheep Maedi/Visna Virus (MVV). Most compounds demonstrated good antireplicative activity against MVV, showing also low cell toxicity.
Vittori
Sauro
S
Dipartimento di Scienze Chimiche, Università di Camerino, Camerino, Italy. sauro.vittori@unicam.it
Salvatori
Daniela
D
Volpini
Rosaria
R
Vincenzetti
Silvia
S
Vita
Alberto
A
Taffi
Sara
S
Costanzi
Stefano
S
Lambertucci
Catia
C
Cristalli
Gloria
G
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects; D003839:Deoxyadenosines / Q000138:chemical synthesis* / Q000494:pharmacology*; D004195:Disease Models, Animal; D007242:Herpesvirus 1, Bovine / Q000187:drug effects; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D012756:Sheep; D014372:Tubercidin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D014777:Virus Diseases / Q000188:drug therapy*; D014779:Virus Replication / Q000187:drug effects*; D014790:Visna-maedi virus / Q000187:drug effects
D000998:Antiviral Agents; D003839:Deoxyadenosines; D014372:Tubercidin