Dinucleoside polyphosphate NAD analogs as potential NMN adenylyltransferase inhibitors. Synthesis and biological evaluation.
Two dinucleoside polyphosphate NAD analogs, P1-(adenosine-5')-P3-(nicotinamide riboside-5')triphosphate (Np3A, 1) and P1-(adenosine-5')-P4-(nicotinamide riboside-5')tetraphosphate (Np4A, 2), were synthesized and tested as inhibitors of both microbial and human recombinant NMN adenylyltransferase. Compounds 1 and 2 proved to be selective inhibitors of microbial enzymes.
Franchetti
P
P
Department of Chemical Sciences, University of Camerino, Camerino, Italy. palmarisa.franchetti@unicam.it
Cappellacci
L
L
Pasqualini
M
M
Grifantini
M
M
Lorenzi
T
T
Raffaelli
N
N
Magni
G
G
D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009243:NAD / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009612:Nicotinamide-Nucleotide Adenylyltransferase / Q000037:antagonists & inhibitors*; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors
D004791:Enzyme Inhibitors; D011994:Recombinant Proteins; D009243:NAD; D009612:Nicotinamide-Nucleotide Adenylyltransferase