Inhibition of vertebrate telomerases by the triphosphate derivatives of some biologically active nucleosides.
In order to clarify the effect of the base moiety of nucleotide analogs on telomerase inhibition, triphosphate derivatives of biologically active nucleosides, 3'-azido-3'-deoxythymidine (AZT), 2'-deoxy-2'-fluoroarafuranosylthymine (FaraT), acycloguanosine (ACG) and their guanine or thymine counterparts (AZdG, FaraG and ACT, respectively) were investigated. In all of the present cases, guanine derivatives showed more potent inhibition than their thymine counterparts.
Yamaguchi
Toyofumi
T
Department of Biological Sciences, Teikyo University of Science and Technology, Uenohara, Yamanashi, Japan.
Takahashi
Hazuki
H
Jinmei
Hiroshi
H
Takayama
Yuko
Y
Saneyoshi
Mineo
M
D000818:Animals; D003854:Deoxyribonucleotides / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006147:Guanine / Q000031:analogs & derivatives; D006367:HeLa Cells; D006801:Humans; D007700:Kinetics; D009711:Nucleotides / Q000494:pharmacology*; D019098:Telomerase / Q000037:antagonists & inhibitors*; D013941:Thymine / Q000031:analogs & derivatives; D014714:Vertebrates
D003854:Deoxyribonucleotides; D004791:Enzyme Inhibitors; D009711:Nucleotides; D006147:Guanine; D019098:Telomerase; D013941:Thymine