Imidazolethyl-phosphoramidate alpha-oligonucleotides.
Alpha-ODNs conjugated to imidazole groups via phosphoramidate internucleosidic linkages were synthesized. The presence of the imidazolethyl-phosphoramidate linkage improved the affinity of alpha-ODNs for their nucleic acid targets.
Michel
T
T
Laboratoire de Chimie Organique Biomoléculaire de Synthèse, Université de Montpellier II, UMR 5625 CNRS-UMII, Montpellier, France.
Mouls
L
L
Debart
F
F
Vasseur
J J
JJ
D000577:Amides; D001483:Base Sequence; D001665:Binding Sites; D007093:Imidazoles; D009693:Nucleic Acid Hybridization; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D010756:Phosphoric Acids
D000577:Amides; D007093:Imidazoles; D009838:Oligodeoxyribonucleotides; D010756:Phosphoric Acids; C011067:phosphoramidic acid