Matrix metalloproteinases: a review of their structure and role in acute coronary syndrome.
OBJECTIVE
To summarize the structure, function, and regulation of matrix metalloproteinases (MMPs) and to review the literature to date on their potential role in the pathogenesis of acute coronary syndromes.


METHODS
A recursive strategy starting with a Medline Search for primary articles in the last decade, followed by identification of additional articles of interest among the cited literature in the primary articles, followed by identification of additional articles of interest cited in the secondary articles.


RESULTS
MMPs play a central role in many fundamental processes in human health and disease. In vitro evidence suggests that MMP activity may facilitate atherosclerosis, plaque destabilization, and platelet aggregation. Limited evidence from clinical studies supports a role of MMPs in the development of acute coronary syndromes.


CONCLUSIONS
MMP activity likely contributes to the development of acute coronary syndromes and may be an important therapeutic target for future drug development.
Jones
Charles B
CB
Department of Internal Medicine/Cardiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
Sane
David C
DC
Herrington
David M
DM
D000208:Acute Disease; D000818:Animals; D003327:Coronary Disease / Q000201:enzymology*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000737:chemistry* / Q000502:physiology*; D010974:Platelet Aggregation / Q000502:physiology; D013329:Structure-Activity Relationship
D020782:Matrix Metalloproteinases