alpha-globin gene deletion and point mutation analysis among in Iranian patients with microcytic hypochromic anemia.
We tested 67 Iranian individuals, presenting with low mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) levels, normal hemoglobin electrophoresis and iron status, for the presence of twelve common alpha-thalassemia gene deletions and point mutations. Five different mutations (-alpha(3.7), -alpha(4.2), --MED, -(alpha)20.5, Hb Constant Spring) were identified in a total of 43 cases
Garshasbi
Masoud
M
Oberkanins
Christian
C
Law
Hai Yang
HY
Neishabury
Maryam
M
Kariminejad
Roxana
R
Najmabadi
Hossein
H
D000747:Anemia, Hypochromic / Q000235:genetics*; D004252:DNA Mutational Analysis / Q000379:methods*; D017353:Gene Deletion; D005914:Globins / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007492:Iran; D017354:Point Mutation / Q000235:genetics*
D005914:Globins