title: Hypoxic oxygen fluctuations produce less severe retinopathy than hyperoxic fluctuations in a rat model of retinopathy of prematurity.
abstract: The aim of this study was to investigate whether the mean around which arterial oxygen fluctuations take place was important in a unique animal model of oxygen-induced retinopathy. Retinopathy of prematurity (ROP) is associated with fluctuating arterial oxygen. A recent retrospective study suggested that management of high-risk preterm infants at lower oxygen saturations was associated with less severe ROP. Rat pups were raised in a variable oxygen environment around a high (24%), normal (21%) or low (17%) mean inspired oxygen for 14 d. Rat pups raised in the high (24%) mean variable oxygen environment had more retarded retinal vascular development than did rats raised in an environment that fluctuated around 21% mean oxygen. In contrast, rats raised in a lower mean (17%) but still variable oxygen environment had no discernible retinal differences from controls raised in constant room air. Rats raised in a relatively hypoxic but variable oxygen environment develop less severe retinal vascular abnormalities than those raised in variable oxygen around higher oxygen means.
authors.affiliation: Child Life and Health, Reproductive and Developmental Sciences, University of Edinburgh, Edingurgh, United Kingdom. jmccolm@email.unc.edu
authors.forename: Janet R
authors.initials: JR
authors.lastname: McColm
authors.forename: Steve
authors.initials: S
authors.lastname: Cunningham
authors.forename: Jean
authors.initials: J
authors.lastname: Wade
authors.forename: Kofi
authors.initials: K
authors.lastname: Sedowofia
authors.forename: Balazs
authors.initials: B
authors.lastname: Gellen
authors.forename: Tarun
authors.initials: T
authors.lastname: Sharma
authors.forename: Neil
authors.initials: N
authors.lastname: McIntosh
authors.forename: Brian W
authors.initials: BW
authors.lastname: Fleck
mesh_terms: D000818:Animals; D001835:Body Weight; D002196:Capillaries / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D018496:Hyperoxia / Q000150:complications* / Q000378:metabolism* / Q000473:pathology; D000860:Hypoxia / Q000150:complications* / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D007231:Infant, Newborn; D037102:Lectins; D051381:Rats; D012160:Retina / Q000378:metabolism / Q000473:pathology; D012171:Retinal Vessels / Q000473:pathology; D012178:Retinopathy of Prematurity / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D012720:Severity of Illness Index
chemical_list: D037102:Lectins