The concept of hemoglobin equivalency of perfluorochemical emulsions.
Perfluorochemical (PFC) emulsions have been in development as intravenous oxygen carriers for a number of years and many publications have dealt with their oxygen transport characteristics in both experimental models and in clinical trials. Though it has been stressed on numerous occasions that PFCs deliver oxygen to the tissues in very different ways to those by which Hemoglobin (Hb) releases oxygen (O2), no serious attempts have been made to correlate the oxygen delivery capacity of PFCs to those of Hb. This paper presents theoretical ways in which this can be done and demonstrates that a 2.7 g/kg dose of PFC is approximately equivalent to 4 g/dL [Hb]. Clinical trial planning is discussed.
Faithfull
N Simon
NS
Alliance Pharmaceutical Corp., San Diego, California, USA.
D002986:Clinical Trials as Topic; D005466:Fluorocarbons / Q000378:metabolism / Q000494:pharmacology*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D010100:Oxygen / Q000378:metabolism*
D005466:Fluorocarbons; D006454:Hemoglobins; D010100:Oxygen