title: Effect of Hibiscus rosa sinensis Linn. ethanol flower extract on blood glucose and lipid profile in streptozotocin induced diabetes in rats.
abstract: Blood glucose and total lipid levels were determined in streptozotocin induced diabetic rats after oral administration of an ethanol flower extract of Hibiscus rosa sinensis. A comparable hypoglycemic effect was evidenced from the data obtained after 7 and 21 days of oral administration of the extract and glibenclamide. Maximal diminution in blood glucose (41-46%) and insulin level (14%) was noticed after 21 days. The extract lowered the total cholesterol and serum triglycerides by 22 and 30%, respectively. The increase in HDL-cholesterol was much higher (12%) under the influence of the extract as compared to that of glibenclamide (1%). The hypoglycemic activity of this extract is comparable to that of glibenclamide but is not mediated through insulin release. Other possible mechanisms are discussed.
authors.affiliation: Department of Chemistry, Faculty of Science, Dayalbagh Educational Institute, Dayalbagh, Agra 282-005, India.
authors.forename: Archana
authors.initials: A
authors.lastname: Sachdewa
authors.forename: L D
authors.initials: LD
authors.lastname: Khemani
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D035264:Flowers; D005952:Glucose-6-Phosphatase / Q000097:blood; D005905:Glyburide / Q000494:pharmacology; D031584:Hibiscus; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000819:agonists / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D013311:Streptozocin; D014508:Urea / Q000097:blood
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D010936:Plant Extracts; D013311:Streptozocin; D014508:Urea; D005952:Glucose-6-Phosphatase; D005905:Glyburide