Landau-Kleffner syndrome responsive to levetiracetam.
A 5-year-old girl with Landau-Kleffner syndrome is discussed. The child began having seizures at age 4 associated with language deterioration despite anticonvulsant therapy. With levetiracetam monotherapy to a dose of 60 mg/kg/day and discontinuation of carbamazepine and valproic acid, her language has improved and seizures are controlled. Levetiracetam should be considered as therapy for Landau-Kleffner syndrome.
Kossoff
Eric H
EH
Department of Neurology, The Johns Hopkins Hospital, Jefferson 128, 600 North Wolfe Street, Baltimore, MD 21287-1000, USA. ekossoff@jhmi.edu
Boatman
Dana
D
Freeman
John M
JM
D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002675:Child, Preschool; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D018887:Landau-Kleffner Syndrome / Q000188:drug therapy* / Q000523:psychology; D007807:Language Tests; D000077287:Levetiracetam; D008570:Memory, Short-Term / Q000187:drug effects; D010889:Piracetam / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D014635:Valproic Acid / Q000009:adverse effects / Q000627:therapeutic use
D000927:Anticonvulsants; D000077287:Levetiracetam; D014635:Valproic Acid; D010889:Piracetam