title: Preventing noise induced otoacoustic emission loss by increasing magnesium (Mg2+) intake in guinea-pigs.
abstract: This study aimed to explore the effects of increased Mg2+ intake on the activity of the outer hair cells as manifested in Click and Distortion Evoked Otoacoustic Emissions (CEOAEs; DPOAEs) in 25 animals. Thirteen animals were fed with high Mg2+ intake (39 mmol Mg2+/l in drinking water) and 12 without the Mg2+ additive. The OAE amplitudes and frequency ranges as well as the DPOAE thresholds were affected significantly less by noise exposure in the animals fed Mg2+-enriched water. Following the exposure, the auditory recovery was faster in the high than the low Mg2+ animals (controls). In addition, a relationship was found between the Mg2+ level and the emission loss. The post-exposure measures may result from the effect of Mg2+ on cochlear metabolic processes and vascular microcirculation. The results demonstrate that pre-existing low Mg2+ levels will exacerbate noise induced hearing loss (NIHL), and increased Mg2+ intake provides a significant biological cochlear protective effect.
authors.affiliation: Department of Communication Disorders, Haifa University, Petach Tikva, Israel. attiasj@netvision.net.il
authors.forename: Joseph
authors.initials: J
authors.lastname: Attias
authors.forename: Ian
authors.initials: I
authors.lastname: Bresloff
authors.forename: Heidemarie
authors.initials: H
authors.lastname: Haupt
authors.forename: Fred
authors.initials: F
authors.lastname: Scheibe
authors.forename: Hartmut
authors.initials: H
authors.lastname: Ising
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D034381:Hearing Loss / Q000503:physiopathology / Q000517:prevention & control*; D008274:Magnesium / Q000097:blood / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D008297:Male; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects*; D010498:Perilymph / Q000378:metabolism
chemical_list: D008274:Magnesium