title: [Bovine serum albumin (BSA) antibodies in children with recently diagnosed type 1 diabetes with breast feeding and milk exposition].
abstract: BACKGROUND
  Environmental and genetic factors (viruses, toxins and diet) are involved in the aetiology of type 1 diabetes. Among the dietary factors, the role of breast feeding and exposure to cow's milk proteins deserve special attention.
  
  
  OBJECTIVE
  To determine the anti-BSA-IgG levels in type 1 diabetic children and to analyse the possible association with breast feeding duration, exposure to cow's milk and beta pancreatic auto-antibodies.
  
  
  METHODS
  Blood samples were collected from 161 diabetic children and 144 controls to measure anti-BSA-IgG level, GAD65, IA-2 and ICA autoantibodies. All children answered a questionnaire about dietary habits during infancy.
  
  
  RESULTS
  anti-BSA-IgG was positive (using a cut off point of 25.6 ng/ml) in 98% of diabetic children and 0% of the control population. The length of breast feeding or early exposure to cow's milk did not influence the concentration of anti-BSA-IgG. Positive BSA titers did not increase the beta pancreatic reactivity (ICA+, GAD+, IA2+).
  
  
  CONCLUSIONS
  Our data confirm the high frequency of anti-BSA-IgG among diabetic children. However, a specific role in the immunological process of type 1 diabetes cannot be attributed to this protein.
authors.affiliation: Programa de Epidemiología Genética, Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile.
authors.forename: Amaya
authors.initials: A
authors.lastname: Oyarzún
authors.forename: J Luis
authors.initials: JL
authors.lastname: Santos
authors.forename: Elena
authors.initials: E
authors.lastname: Carrasco
authors.forename: Cecilia
authors.initials: C
authors.lastname: Albala
authors.forename: Alfonso
authors.initials: A
authors.lastname: Salinas
authors.forename: Francisco
authors.initials: F
authors.lastname: Pérez
mesh_terms: D000293:Adolescent; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D001942:Breast Feeding; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000302:isolation & purification*; D008297:Male; D008892:Milk; D012710:Serum Albumin, Bovine / Q000276:immunology*; D013997:Time Factors
chemical_list: D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D007074:Immunoglobulin G; C048844:anti-IgG; D012710:Serum Albumin, Bovine