title: Seroreactivity against Saccharomyces cerevisiae in patients with Crohn's disease and celiac disease.
abstract: OBJECTIVE
  To explore whether there was anti-Saccharomyces cerevisiae antibodies (ASCA) positivity in our patients with biopsy-confirmed celiac disease.
  
  
  METHODS
  A cohort of patients with inflammatory bowel diseases (42 patients with Crohn's disease and 10 patients with ulcerative colitis) and gluten sensitive enteropathy (16 patients) from Debrecen, Hungary were enrolled in the study. The diagnosis was made using the formally accepted criteria. Perinuclear antineutrophil cytoplasmic antibodies (pANCA) and anti-Saccharomyces cerevisiae antibodies (ASCA), antiendomysium antibodies (EMA), antigliadin antibodies (AGA) and anti human tissue transglutaminase antibodies (tTGA) were investigated.
  
  
  RESULTS
  The results showed that ASCA positivity occurred not only in Crohn's disease but also in Celiac disease and in these cases both the IgG and IgA type antibodies were proved.
  
  
  CONCLUSIONS
  It is conceivable that ASCA positivity correlates with the (auto-) immune inflammation of small intestines and it is a specific marker of Crohn's disease.
authors.affiliation: 3rd Dept. of Medicine, University of Debrecen, Moricz Zs. Krt.22. 4004 Debrecen, Hungary. barta@iiibel.dote.hu
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Barta
authors.forename: István
authors.initials: I
authors.lastname: Csípõ
authors.forename: Gábor G
authors.initials: GG
authors.lastname: Szabó
authors.forename: Gyula
authors.initials: G
authors.lastname: Szegedi
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D000908:Antibodies, Fungal / Q000097:blood*; D002446:Celiac Disease / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology*; D015331:Cohort Studies; D003424:Crohn Disease / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology*; D005260:Female; D005903:Gliadin / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D012441:Saccharomyces cerevisiae / Q000276:immunology*; D016036:Seroepidemiologic Studies
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D000908:Antibodies, Fungal; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin