Synthesis of halogenated 9-(dihydroxycyclopent-4'-enyl) adenines and their inhibitory activities against S-adenosylhomocysteine hydrolase.
Novel halovinyl analogues of neplanocin A without 4'-hydroxymethyl group were easily synthesized starting from D-ribose via cyclopentenone 5 as a key intermediate and their inhibitory activity against SAH hydrolase was assayed.
Jeong
Lak Shin
LS
College of Pharmacy, Ewha Womans University, Seoul, South Korea. lakjeong@ewha.ac.kr
Park
Jae Gyu
JG
Choi
Won Jun
WJ
Moon
Hyung Ryong
HR
Lee
Kang Man
KM
Kim
Hea Ok
HO
Kim
Hee-Doo
HD
Chun
Moon Woo
MW
Park
Hea-Young
HY
Kim
Kilhyoun
K
Sheen
Yhun Y
YY
D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000241:Adenosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D043383:Adenosylhomocysteinase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; C031096:neplanocin A; D043383:Adenosylhomocysteinase; D000225:Adenine; D000241:Adenosine