title: New benzylidenethiazolidinediones as antibacterial agents.
abstract: A novel benzylidenethiazolidinedione has been discovered with antimicrobial activity. Here, we present the results of a structure-activity study on this compound with respect to its antimicrobial activity.
authors.affiliation: Medicinal Chemistry Department, Microbial, Musculoskeletal and Proliferative Diseases, GlaxoSmithKline Pharmaceuticals, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. dirk_a_heerding@sbphrd.com
authors.forename: Dirk A
authors.initials: DA
authors.lastname: Heerding
authors.forename: Lisa T
authors.initials: LT
authors.lastname: Christmann
authors.forename: Tammy J
authors.initials: TJ
authors.lastname: Clark
authors.forename: David J
authors.initials: DJ
authors.lastname: Holmes
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Rittenhouse
authors.forename: Dennis T
authors.initials: DT
authors.lastname: Takata
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Venslavsky
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013329:Structure-Activity Relationship; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D001593:Benzyl Compounds; D007202:Indicators and Reagents; D045162:Thiazolidinediones