A convenient method for the synthesis of 2-(beta-D-glycopyranosylthio) pyridines.
Treatment of piperidinium salts of dihydropyridinethiolates 3 with glycosyl bromides 4 in dry acetone provides a convenient and high yielding synthesis of 1,4-dihydro-3-cyanopyridine thioglycosides 5. The structures of 5 were confirmed by oxidation as well as by 1H NMR and 13C NMR spectral analysis.
Attia
Adel M E
AM
Department of Chemistry, Faculty of Education, University of Tanta (Kafr El-Sheikh Branch), Tanta, Egypt. adelmattia@hotmail.com
El-Shehawy
Ashraf A
AA
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002460:Cell Line; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013865:Thioglycosides / Q000138:chemical synthesis* / Q000737:chemistry
D019380:Anti-HIV Agents; D004095:Dihydropyridines; D013865:Thioglycosides