title: Synthesis of carbocyclic analogues of MECA and NECA 1,2-disubstituted as potential adenosine receptor agonists.
abstract: A new class of 1,2-disubstituted carbocyclic nucleosides of MECA and NECA analogues was synthesized in good yield starting from (+/-) 6-azabicyclo[3.2.0]heptan-7-one.
authors.affiliation: Departamento de Química Orgánica, Universidad de Vigo, Pontevedra, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Besada
authors.forename: M J
authors.initials: MJ
authors.lastname: González-Moa
authors.forename: C
authors.initials: C
authors.lastname: Terán
authors.forename: M
authors.initials: M
authors.lastname: Teijeira
authors.forename: L
authors.initials: L
authors.lastname: Santana
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D019830:Adenosine-5'-(N-ethylcarboxamide) / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D058906:Purinergic P1 Receptor Agonists; D011687:Purines / Q000138:chemical synthesis
chemical_list: D007202:Indicators and Reagents; D058906:Purinergic P1 Receptor Agonists; D011687:Purines; C046756:5'-N-methylcarboxamideadenosine; D019830:Adenosine-5'-(N-ethylcarboxamide); D000241:Adenosine