title: Betaxolol attenuates retinal ischemia/reperfusion damage in the rat.
abstract: This study was performed to elucidate the protection afforded by post-treatment with Betoptic (0.25% betaxolol) against neuronal cell damage after ischemia/reperfusion insult in rats. Betaxolol was applied topically after the start of reperfusion and its effect was evaluated by morphometry and choline acetyltransferase immunoreactivity of retinas at 7 days after reperfusion. In non-treated eyes, the thickness of the inner plexiform layer decreased markedly after a reperfusion period of both 3 and 7 days. However, when eyes were treated with betaxolol after ischemia/reperfusion injury, both the reduction of the inner plexiform layer thickness and the retinal choline acetyltransferase immunoreactivity were significantly attenuated. These findings suggest that betaxolol is an efficient neuroprotective agent and prevents the retinal cell damage induced by ischemic injury in rats.
authors.affiliation: Department of Anatomy and Neurobiology, Health Science Institute, Gyeongsang National University, Chinju, South Korea.
authors.forename: Eun Woo
authors.initials: EW
authors.lastname: Cheon
authors.forename: Chang Hwan
authors.initials: CH
authors.lastname: Park
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Kang
authors.forename: Gyeong Jae
authors.initials: GJ
authors.lastname: Cho
authors.forename: Ji Myong
authors.initials: JM
authors.lastname: Yoo
authors.forename: Joon Kyung
authors.initials: JK
authors.lastname: Song
authors.forename: Wan Sung
authors.initials: WS
authors.lastname: Choi
mesh_terms: D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D015784:Betaxolol / Q000008:administration & dosage / Q000627:therapeutic use*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D007150:Immunohistochemistry; D007429:Intraocular Pressure / Q000187:drug effects / Q000502:physiology; D008297:Male; D018696:Neuroprotective Agents; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy* / Q000473:pathology; D012160:Retina / Q000201:enzymology / Q000473:pathology*; D012162:Retinal Degeneration / Q000473:pathology / Q000517:prevention & control
chemical_list: D000319:Adrenergic beta-Antagonists; D018696:Neuroprotective Agents; D002795:Choline O-Acetyltransferase; D015784:Betaxolol