title: [Study on gamma-synuclein gene in patients with idiopathic Parkinson's disease].
abstract: OBJECTIVE
  To evaluate the relationship between idiopathic Parkinson's disease (PD) and two polymorphisms (C243G and A377T) of the gamma-synuclein gene in a Chinese Han population of Shanghai area.
  
  
  METHODS
  Polymorphic genotyping was performed with PCR-RPLP technique. Association analysis was carried out in 145 unrelated idiopathic PD patients and 184 age-matched healthy controls.
  
  
  RESULTS
  The authors failed to detect any distributional difference of the C243G and A377T polymorphisms of the gamma-synuclein gene between PD cases and control subjects, nor did they find any association.
  
  
  CONCLUSIONS
  These data do not support that gamma-synuclein gene C243G and A377T polymorphisms are involved in idiopathic PD onset in the Han population of Shanghai area.
authors.affiliation: Department of Neurology, Changhai Hospital, the Second Military Medical University, Shanghai, 200433 P R China. jjsulcg@yahoo.com
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Su
authors.forename: Hui-jun
authors.initials: HJ
authors.lastname: Xie
authors.forename: Wu-wei
authors.initials: WW
authors.lastname: Zhao
authors.forename: Hai-xiong
authors.initials: HX
authors.lastname: Han
authors.forename: Tong
authors.initials: T
authors.lastname: Gao
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.forename: Guo-mei
authors.initials: GM
authors.lastname: Tang
authors.forename: Da-ming
authors.initials: DM
authors.lastname: Ren
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D051843:Synucleins; D051845:gamma-Synuclein
chemical_list: D009419:Nerve Tissue Proteins; D051843:Synucleins; D051845:gamma-Synuclein