title: Environmental tobacco smoke, carcinogenesis, and angiogenesis: a double whammy?
abstract: In this issue of Cancer Cell, Zhu and coworkers demonstrate that environmental tobacco smoke (ETS) results in tumor angiogenesis, and provide evidence that the responsible factor in ETS is nicotine. While a weak carcinogen, nicotine promotes carcinogenesis by a number of different mechanisms. The authors' findings provide further evidence of the harmful effects of ETS and indicate the desirability of reducing exposure to it.
authors.affiliation: Hamon Center for Therapeutic Oncology Research and Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75390, USA. adi.gazdar@utsouthwestern.edu
authors.forename: Adi F
authors.initials: AF
authors.lastname: Gazdar
mesh_terms: D002273:Carcinogens / Q000633:toxicity*; D004781:Environmental Exposure; D006801:Humans; D009389:Neovascularization, Pathologic / Q000209:etiology*; D009538:Nicotine / Q000633:toxicity*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D002273:Carcinogens; D014028:Tobacco Smoke Pollution; D009538:Nicotine