Five new mouse susceptibility to colon cancer loci, Scc11-Scc15.
Although several genes causing familial cancer syndromes have been identified, susceptibility to sporadic cancer remains unsolved. Animal experiments have demonstrated a large number of quantitative trait loci affecting cancer susceptibility. Previously, we described in mouse strain CcS-19/Dem five susceptibility to colon cancer (Scc) loci, Scc1-Scc5 controlling tumor numbers. In the present study, we performed an independent identical mouse cross using a distinct carcinogen, azoxymethane, to induce colon tumors. We confirmed all five originally described Scc loci and detected five additional new Scc loci; Scc11-Scc15. All these loci were detected in two-way interactions.
Ruivenkamp
Claudia A L
CA
Division of Molecular Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, The Netherlands.
Csikós
Tamás
T
Klous
Anita M
AM
van Wezel
Tom
T
Demant
Peter
P
D000818:Animals; D003110:Colonic Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D051379:Mice