title: [Therapeutic safety of antimycotics in the treatment of systemic fungal infections].
abstract: The authors summarize the most important data of antimycotics used in the praxis. The indications of these drugs as well as the absorption, the antimycotic mechanism, the side-effects and drug-interactions of antifungal agents are discussed. The pathomechanism of amphotericin B, flucytosine, fluconasole, ketoconasole, itraconasole and the possibilities of their clinical administrations, further their side-effects and interactions are demonstrated in details. The most beneficial characteristics and more important interactions of these drugs are shown in tables for easier application in the everyday therapy.
authors.affiliation: Semmelweis Egyetem, Altalános Orvostudományi Kar, II. Belklinika, Budapest. feher@bel2.sote.hu
authors.forename: János
authors.initials: J
authors.lastname: Fehér
authors.forename: Gabriella
authors.initials: G
authors.lastname: Lengyel
mesh_terms: D000666:Amphotericin B / Q000009:adverse effects; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004347:Drug Interactions; D015725:Fluconazole / Q000009:adverse effects; D005437:Flucytosine / Q000009:adverse effects; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects; D007654:Ketoconazole / Q000009:adverse effects; D008099:Liver / Q000187:drug effects; D009181:Mycoses / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine; D007654:Ketoconazole