[Chemokine--possible new options for the treatment of multiple sclerosis].
Accumulation and activation of mononuclear cells (lymphocytes and monocytes) in the CNS is one of the crucial steps in the pathogenesis of multiple sclerosis (MS). Chemokines and their receptors govern physiological and pathological leukocyte trafficking and may also be pertinent in hematogenous leukocyte infiltration of the CNS. Due to broad pharmacological interest in the chemokine system, peptide antagonists and small molecular antagonists are now available for clinical therapeutic trials. For the treatment of MS in particular, the chemokine receptors CCR1, CCR2, CCR5, and CXCR3 are possible targets in a chemokine-based therapeutic approach. In this review, we summarize current knowledge of the roles of chemokines and chemokine receptors in the pathogenesis of MS. Furthermore, options for possible therapeutic intervention through the chemokine system are outlined. Clinical studies in MS patients applying this knowledge are expected soon.
Trebst
C
C
Neurologische Klinik, Medizinische Hochschule Hannover. trebst.corinna@mh-hannover.de
Ransohoff
R M
RM
Windhagen
A
A
Stangel
M
M
D000818:Animals; D018925:Chemokines / Q000037:antagonists & inhibitors* / Q000502:physiology; D006801:Humans; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000276:immunology; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors* / Q000502:physiology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D018925:Chemokines; D019707:Receptors, Chemokine