[How to obtain complete control of asthma?].
Long acting beta 2-agonists (LABA) and glycocorticosteroids (GCS) are the most effective groups of drugs recommended in the treatment of asthma. They are more effective if administered together. GCS have been used as anti-inflammatory agents while LABA as bronchodilatatory drugs. It has not been fully elucidated whether LABA exert in vivo any anti-inflammatory effect that was demonstrated in vitro. The interaction between these drugs at the biochemical and clinical levels was confirmed many times. The mechanisms of interactions between GCS and LABA are, however, still being discussed. LABA may affect glukocorticosteroid receptor (GR) location through modulation of GR phosphorylation and further may prime GR function within the cell nucleus by modifying GR or GR-associated protein phosphorylation. Glucocoricosteroids may, in turn, regulate beta 2-adrenoceptor (beta 2 AR) function by increasing its expression, acting by restoring the ability of G-protein beta 2 AR coupling and inhibiting beta 2 AR down-regulation, thereby preventing desensitisation associated with long term LABA administration.
Chazan
Ryszarda
R
Katedra i Klinika Chorób Wewnetrznych Pneumonologii i Alergologii Akademii Medycznej w Warszawie.
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D006801:Humans
D000318:Adrenergic beta-Agonists; D000893:Anti-Inflammatory Agents