title: Switching cyclosporine blood concentration monitoring from C0 to C2 in children late after liver transplantation.
abstract: BACKGROUND
  Measurement of cyclospoprine (CsA) blood levels at 2 hours after oral administration (C(2)) has been proposed as a better measurement of trough level (C(0)) due to reduced intrapatient variability, acute rejection rate and renal toxicity. The aim of the present study was to assess whether there was any advantage to conversion from C(0) to C(2) CsA blood level monitoring in children late after liver transplantation. We reviewed the data from 44 children more than 1 year after liver transplantation. We measured the daily dose of CsA and the C(0) level before switching versus the daily dose and C(2) level at 6 months after conversion, in addition to the alanine aminotransferase (ALT) activity, creatinine blood concentration, and episodes of acute rejection.
  
  
  RESULTS
  Conversion from C(0) to C(2) monitoring was not associated with a significant change in mean daily dose of CsA, mean concentration of creatinine, ALT activity or occurrence of rejection episodes.
  
  
  CONCLUSIONS
  Switching from C(0) to C(2) monitoring did not seem to proffer any benefits for children late after liver transplantation.
authors.affiliation: Department of Pediatric Surgery and Organ Transplantation, The Children's Memorial Health Institute, Warsaw, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Teisseyre
authors.forename: M
authors.initials: M
authors.lastname: Markiewicz
authors.forename: T
authors.initials: T
authors.lastname: Drewniak
authors.forename: P
authors.initials: P
authors.lastname: Kalicinski
authors.forename: A
authors.initials: A
authors.lastname: Kaminski
authors.forename: H
authors.initials: H
authors.lastname: Ismail
authors.forename: M
authors.initials: M
authors.lastname: Szymczak
authors.forename: M
authors.initials: M
authors.lastname: Teisseyre
authors.forename: P
authors.initials: P
authors.lastname: Nachulewicz
mesh_terms: D000284:Administration, Oral; D002648:Child; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000008:administration & dosage / Q000097:blood*; D016903:Drug Monitoring / Q000379:methods; D006084:Graft Rejection / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000097:blood*; D016031:Liver Transplantation / Q000276:immunology*; D011184:Postoperative Period; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003404:Creatinine