Sepsis and the dendritic cell.
Sepsis is a syndrome of significant morbidity and mortality. Unlike the advances made in other diseases processes, improvements in outcome from sepsis, severe sepsis, and septic shock have been modest. Current research has altered our understanding of sepsis pathogenesis such that present models and definitions are still evolving. One relatively novel cell type, the dendritic cell, is the subject of much current investigation in sepsis. Although our present understanding of dendritic cell biology is incomplete, growing evidence supports the importance of this antigen-presenting cell in the normal and maladaptive responses to microbial invasion and tissue injury. A better understanding of this cell's basic biology as well as its potential as a therapeutic target will undoubtedly play increasing roles in the development of new strategies for the treatment of the septic patient.
Efron
Philip
P
Department of Surgery, University of Florida College of Medicine, Gainesville 32610, USA.
Moldawer
Lyle L
LL
D000818:Animals; D015703:Antigens, CD / Q000502:physiology; D000954:Antigens, Surface / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D018925:Chemokines / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology / Q000382:microbiology / Q000502:physiology*; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D007109:Immunity / Q000502:physiology; D018448:Models, Immunological; D019707:Receptors, Chemokine / Q000502:physiology; D018805:Sepsis / Q000276:immunology* / Q000503:physiopathology; D018746:Systemic Inflammatory Response Syndrome / Q000503:physiopathology / Q000628:therapy
D015703:Antigens, CD; D000954:Antigens, Surface; D018925:Chemokines; D019707:Receptors, Chemokine