title: The impact of 2-deoxy-2[18F] fluoro-D-glucose whole body positron emission tomography for managing patients with melanoma: the referring physician's perspective.
abstract: OBJECTIVE
  Whole body positron emission tomography (PET) imaging with 2-deoxy-2[18F]fluoro-D-glucose (FDG) has been used successfully to diagnose and stage melanoma. The impact of FDG-PET, however, on patient stage and management from the referring physicians' perspective is unknown.
  
  
  METHODS
  A questionnaire was sent to referring physicians to investigate whether and how PET altered clinical decision in treatment of melanoma patients. Surveys were sent to referring physicians of every melanoma patient who had a PET scan performed at UCLA or the Northern California PET Imaging Center (NCPIC). Data were used to evaluate the impact of FDG-PET on clinical management of melanoma patients based on pre-PET and post-PET staging. Management changes were classified as inter-modality if therapy changed from one modality to another or intra-modality if changes were made within a treatment modality.
  
  
  RESULTS
  Fifty-one questionnaires (response rate of 35%) have been received to date. Referring physicians indicated that whole body FDG-PET changed the clinical stage in 15 out of 51 (29%) patients: 10 (20%) were up-staged and five (10%) were down-staged. The PET findings resulted in inter-modality management changes in 15 out of 51 patients (29%). Intra-modality management change occurred in nine patients (18%).
  
  
  CONCLUSIONS
  From the referring physicians' perspective, FDG-PET has a major impact and results in management changes in 53% of patients with melanoma.
authors.affiliation: Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Clinic/Nuclear Medicine, UCLA School of Medicine, Los Angeles, CA 90095, USA.
authors.forename: Catharina
authors.initials: C
authors.lastname: Wong
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Silverman
authors.forename: Marc
authors.initials: M
authors.lastname: Seltzer
authors.forename: Christiaan
authors.initials: C
authors.lastname: Schiepers
authors.forename: Maryam
authors.initials: M
authors.lastname: Ariannejad
authors.forename: Sanjiv S
authors.initials: SS
authors.lastname: Gambhir
authors.forename: Michael E
authors.initials: ME
authors.lastname: Phelps
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Rao
authors.forename: Peter
authors.initials: P
authors.lastname: Valk
authors.forename: Johannes
authors.initials: J
authors.lastname: Czernin