title: Subungual melanoma with osteocartilaginous differentiation.
abstract: Osteocartilaginous metaplasia is known to occur rarely in melanomas, particularly in subungual melanomas. We present a case of a calcified subungual soft tissue tumour in which biopsy of the lesion showed malignant round and spindle-shaped tumour cells, many of which were associated with the formation of cartilage and osteoid-like material. Subsequent resection showed clear histological evidence of a subungual melanoma. Tumour cells expressed S100, melan-A and neurone-specific enolase but were negative for HMB45. Diagnostic radiological and histological features and the nature of the osteocartilaginous differentiation within this lesion is discussed.
authors.affiliation: Nuffield Department of Orthopaedic Surgery, University of Oxford, Nuffield Orthopaedic Centre, Oxford, OX3 7LD, UK.
authors.forename: H
authors.initials: H
authors.lastname: Giele
authors.forename: K
authors.initials: K
authors.lastname: Hollowood
authors.forename: C L M H
authors.initials: CL
authors.lastname: Gibbons
authors.forename: D J
authors.initials: DJ
authors.lastname: Wilson
authors.forename: N A
authors.initials: NA
authors.lastname: Athanasou
mesh_terms: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D001706:Biopsy; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology; D002356:Cartilage / Q000000981:diagnostic imaging / Q000473:pathology; D003937:Diagnosis, Differential; D005385:Fingers / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D058965:MART-1 Antigen; D008279:Magnetic Resonance Imaging; D008297:Male; D008545:Melanoma / Q000175:diagnosis*; D058950:Melanoma-Specific Antigens; D008875:Middle Aged; D009363:Neoplasm Proteins; D015831:Osteochondroma / Q000175:diagnosis* / Q000473:pathology; D012516:Osteosarcoma / Q000175:diagnosis / Q000473:pathology; D010751:Phosphopyruvate Hydratase; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D058965:MART-1 Antigen; C548667:MLANA protein, human; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D010751:Phosphopyruvate Hydratase