title: Bidirectional ventricular tachycardia and channelopathy.
abstract: Based on similarity of electrocardiographic features, bidirectional ventricular tachycardia has been considered a variant of long QT syndrome. Genes causing long QT syndrome were used as candidate genes in 4 patients with bidirectional ventricular tachycardia. In 2 patients, we identified a common low penetrance HERG allele (R1047L) with an intermediate biophysical phenotype.
authors.affiliation: Bumgrad Hospital, Bangkok, Thailand.
authors.forename: Preecha
authors.initials: P
authors.lastname: Laohakunakorn
authors.forename: D Woodrow
authors.initials: DW
authors.lastname: Benson
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.forename: Dan M
authors.initials: DM
authors.lastname: Roden
authors.forename: John D
authors.initials: JD
authors.lastname: Kugler
mesh_terms: D000293:Adolescent; D000483:Alleles; D027682:Cation Transport Proteins; D002675:Child, Preschool; D004268:DNA-Binding Proteins; D000072237:ERG1 Potassium Channel; D022062:Electrophysiologic Techniques, Cardiac; D051638:Ether-A-Go-Go Potassium Channels; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000235:genetics*; D008297:Male; D010641:Phenotype; D015221:Potassium Channels / Q000235:genetics*; D024642:Potassium Channels, Voltage-Gated; D015222:Sodium Channels / Q000235:genetics; D017180:Tachycardia, Ventricular / Q000235:genetics*; D015534:Trans-Activators; D000071230:Transcriptional Regulator ERG
chemical_list: D027682:Cation Transport Proteins; D004268:DNA-Binding Proteins; C072312:ERG protein, human; D000072237:ERG1 Potassium Channel; D051638:Ether-A-Go-Go Potassium Channels; C000606913:KCNH2 protein, human; C092509:KCNH6 protein, human; D015221:Potassium Channels; D024642:Potassium Channels, Voltage-Gated; D015222:Sodium Channels; D015534:Trans-Activators; D000071230:Transcriptional Regulator ERG