title: Fetoplacental vascular tone is modified by magnesium sulfate in the preeclamptic ex vivo human placental cotyledon.
abstract: OBJECTIVE
  The purpose of this study was to evaluate fetoplacental vascular tone and response to a vasoconstrictor in placentas of preeclamptic and normotensive pregnancies with and without the presence of magnesium sulfate.
  
  
  METHODS
  Two cotyledons from each placenta were selected from preeclamptic (n=8) and normotensive (n=7) pregnancies. In one cotyledon from each pair, the maternal circuit was perfused with magnesium sulfate. The fetal arteries were injected sequentially with angiotensin II (10(-10)mol and 10(-11.5) mol). Perfusion pressures and response to angiotensin II were compared, with regard to preeclampsia and exposure to magnesium sulfate.
  
  
  RESULTS
  Perfusion pressure was higher in preeclamptic placentas, compared with normotensive placentas (30.4 mm Hg vs 24.4 mm Hg, P=.02). There was a decrease in perfusion pressure with exposure to magnesium sulfate in preeclamptic placentas (22.5 mm Hg, P<.01), but not in normotensive placentas. Fetoplacental vascular response to angiotensin II was not affected by preeclampsia or magnesium sulfate.
  
  
  CONCLUSIONS
  In placentas from preeclamptic pregnancies there is increased fetoplacental perfusion pressure, which decreases with exposure to sulfate.
authors.affiliation: Division of Maternal-Fetal Medicine, Madigan Army Medical Center, Tacoma, Wash., USA. cmkovac123@aol.com
authors.forename: Christine M
authors.initials: CM
authors.lastname: Kovac
authors.forename: Bobby C
authors.initials: BC
authors.lastname: Howard
authors.forename: Brian T
authors.initials: BT
authors.lastname: Pierce
authors.forename: Nathan J
authors.initials: NJ
authors.lastname: Hoeldtke
authors.forename: Byron C
authors.initials: BC
authors.lastname: Calhoun
authors.forename: Peter G
authors.initials: PG
authors.lastname: Napolitano
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology; D001158:Arteries / Q000187:drug effects / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000098:blood supply*; D006801:Humans; D008278:Magnesium Sulfate / Q000494:pharmacology*; D010477:Perfusion; D010920:Placenta / Q000098:blood supply*; D011225:Pre-Eclampsia / Q000503:physiopathology*; D011247:Pregnancy
chemical_list: D000804:Angiotensin II; D008278:Magnesium Sulfate