[Flu vaccination in patients with acute coronary syndromes: treatment benefit in prespecified subgroups].
BACKGROUND
The first prospective clinical Flu Vaccination in Acute Coronary Syndromes (FLUVACS) Trial has provided some evidence that flu vaccination together with standard therapy may be useful during the winter season to reduce the risk of death and major cardiac events in patients with acute myocardial infarction.


METHODS
Information available in the FLUVACS database was analyzed to evaluate the efficacy of flu vaccination in different subgroups. Logistic regression was used to identify features related with better therapeutic results.


RESULTS
Flu vaccination was effective in reducing the incidence of the composite endpoint (death, nonfatal myocardial reinfarction or recurrent angina prompting urgent revascularization) in most subgroups at 6 months after inclusion. The regression model showed a greater benefit of flu vaccination in patients with no ST-segment elevation or older than 65 years, nonsmokers and patients with a TIMI risk score higher than 6.


CONCLUSIONS
Our data suggest that vaccination for secondary prevention of flu during the acute phase of myocardial infarction may be effective in a broad range of patients with acute coronary artery disease, regardless of their initial clinical risk.
León de la Fuente
Ricardo
R
Instituto de Cardiología y Cirugía Cardiovascular, Fundación Favaloro, Buenos Aires, Argentina.
Gurfinkel
Enrique P
EP
Toledo
Diego
D
Mautner
Branco
B
D000208:Acute Disease; D000368:Aged; D003327:Coronary Disease / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007252:Influenza Vaccines / Q000627:therapeutic use*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D013577:Syndrome
D007252:Influenza Vaccines