[Effects of ocular hypotensive agents on the circadian rhythm in intraocular pressure in rabbits as measured by telemetry].
OBJECTIVE
To establish a telemetry system for measuring intraocular pressure (IOP) in rabbits and to evaluate the effects of topical application of ocular hypotensive agents on the circadian rhythm of IOP.


METHODS
We developed a telemetry system in rabbits housed under a 12-hour light-dark cycle (light and dark phases: 7:00-19:00, 19:00-7:00, respectively). The IOP resulting from a single topical application of ocular hypotensive agents was measured by telemetry during the light phase and the dark phase.


RESULTS
The values measured by the telemetry were positively correlated to the value of the anterior chamber pressure measured by a transducer in range from 5 to 50 mmHg (r = 0.987). A single topical application of timolol maleate (0.5%), dorzolamide hydrochloride (1%), and dipivefrine hydrochloride (0.1%) caused no significant reduction in IOP in the light phase, but they did in the dark phase. A single topical application of bunazosin hydrochloride (0.01% or 0.1%) had significant ocular hypotensive effects in both phases.


CONCLUSIONS
These findings indicate that the different effects of ocular hypotensive agents on circadian rhythms of IOP can be measured by the telemetry. Telemetry may be useful for evaluation of ocular hypotensive agents and the circadian rhythm of IOP.
Akaishi
Takahiro
T
Research and Development Division, Research and Development Center, Santen Pharmaceutical Co., Ltd., Ikoma, Japan.
Shimazaki
Atsushi
A
Matsugi
Takeshi
T
Miyawaki
Nobuaki
N
Hara
Hideaki
H
Kuwayama
Yasuaki
Y
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects*; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D011799:Quinazolines / Q000494:pharmacology*; D011817:Rabbits; D013449:Sulfonamides / Q000494:pharmacology*; D013686:Telemetry; D013876:Thiophenes / Q000494:pharmacology*; D013999:Timolol / Q000494:pharmacology*
D011799:Quinazolines; D013449:Sulfonamides; D013876:Thiophenes; D013999:Timolol; C062765:dorzolamide; C018176:bunazosin