Nuclease stability of LNA oligonucleotides and LNA-DNA chimeras.
The stabilizing properties of LNA and alpha-L-LNA oligonucleotides against endo- and 3'-exonucleases have been evaluated.
Frieden
Miriam
M
Cureon A/S, Copenhagen, Denmark.
Hansen
Henrik F
HF
Koch
Troels
T
D004247:DNA / Q000737:chemistry*; D004355:Drug Stability; D004722:Endoribonucleases / Q000378:metabolism; D005092:Exonucleases / Q000378:metabolism*; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense / Q000737:chemistry*; D043264:Phosphodiesterase I; D013379:Substrate Specificity
D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; C477371:locked nucleic acid; C027903:oligo (dT); D004247:DNA; D004722:Endoribonucleases; D005092:Exonucleases; C022650:spleen exonuclease; D043264:Phosphodiesterase I; C470790:phosphodiesterase I, snake venom