Impact of interstitial lung disease on surgical morbidity and mortality for lung cancer: analyses of short-term and long-term outcomes.
BACKGROUND
This study investigated postoperative morbidity, mortality, and the long-term survival for patients with lung cancer who have interstitial lung diseases.


METHODS
A retrospective chart review of 931 patients with lung cancer who underwent pulmonary resection at Chiba University Hospital between 1990 and 2000 was undertaken. Interstitial lung disease was defined by medical history, physical examination, and abnormalities compatible with bilateral lung fibrosis on chest computed tomography or high-resolution computed tomography (36 patients: 3.9%, interstitial lung diseases group). The remaining 895 patients (96.1%) were categorized as non-interstitial lung disease group.


RESULTS
The incidence of postoperative pneumonia and acute or exacerbation of interstitial pneumonia was higher in the interstitial lung disease group (all P <.05). Thirty-day mortality was statistically equivalent between the interstitial lung disease and the non-interstitial lung disease groups (P =.30). The 5-year overall survivals were 62.5% (non-interstitial lung disease) and 35.6% (interstitial lung disease). Respiratory failure was the second main cause of death after the recurrence of primary cancer in the interstitial lung disease group. The risk factors for long-term mortality were interstitial lung diseases, advanced pathologic stage, male sex, high age, and positive smoking history (all P <.05).


CONCLUSIONS
Interstitial lung disease was a risk factor for developing postoperative morbidity and mortality and poor long-term survival due to the occurrence of respiratory failure.
Chiyo
Masako
M
Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.
Sekine
Yasuo
Y
Iwata
Takekazu
T
Tatsumi
Koichiro
K
Yasufuku
Kazuhiro
K
Iyoda
Akira
A
Otsuji
Mizuto
M
Yoshida
Shigetoshi
S
Shibuya
Kiyoshi
K
Iizasa
Toshihiko
T
Saitoh
Yukio
Y
Fujisawa
Takehiko
T
D000367:Age Factors; D000368:Aged; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000209:etiology; D008175:Lung Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011014:Pneumonia / Q000209:etiology; D011183:Postoperative Complications; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects