title: Short term therapy for uncomplicated urinary tract infection today. Clinical outcome upholds the theories.
abstract: The clinical and bacteriological activity of fosfomycin trometamol (FT) has been compared with several other antibiotics in the treatment of uncomplicated urinary tract infections. A single dose of FT had activity comparable with a 5-day course of trimethoprim in a trial where the causative organism and its sensitivity were unknown. In another trial FT showed better long term eradication compared with a 5-day course of cephalexin and other studies suggested a single dose of FT was comparable with a 7-day course of nitrofurantoin or norfloxacin. There were few important side effects with fosfomycin therapy and it was considered a safe and effective first line treatment in uncomplicated urinary tract infection.
authors.affiliation: Department of Urology, Hopital Pontchaillou, Rue Henri le Guilloux, F-35033, Rennes, France. bernard.lobel@chu-rennes.fr
authors.forename: B
authors.initials: B
authors.lastname: Lobel
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy; D002506:Cephalexin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005260:Female; D005578:Fosfomycin / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008137:Longitudinal Studies; D015201:Meta-Analysis as Topic; D009582:Nitrofurantoin / Q000008:administration & dosage / Q000627:therapeutic use; D009643:Norfloxacin / Q000627:therapeutic use; D016896:Treatment Outcome; D014295:Trimethoprim / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D009582:Nitrofurantoin; D014295:Trimethoprim; D009643:Norfloxacin; D002506:Cephalexin