title: QSAR study on antibacterial activity of sulphonamides and derived Mannich bases.
abstract: The paper describes synthesis and comparative study on antibacterial activities of sulphonamides and Mannich bases derived from them. The compounds were screened for their antibacterial activity against various gram-positive and gram-negative bacteria and were analyzed statistically. The results have shown that the compounds are quiet active against pathogens under study and were nontoxic.
authors.affiliation: School of Chemical Sciences, Devi Ahilya Vishwavidyalaya, Takshila campus, Khandwa Road, Indore (M.P.), India. spjoshi11@rediffmail.com
authors.forename: Sheela
authors.initials: S
authors.lastname: Joshi
authors.forename: Navita
authors.initials: N
authors.lastname: Khosla
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004121:Dimethyl Sulfoxide; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008352:Mannich Bases / Q000737:chemistry*; D051379:Mice; D008826:Microbial Sensitivity Tests; D021281:Quantitative Structure-Activity Relationship; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000900:Anti-Bacterial Agents; D008352:Mannich Bases; D012997:Solvents; D013449:Sulfonamides; D004121:Dimethyl Sulfoxide