Optimizing long-term cardiac management after major vascular surgery: Role of beta-blocker therapy, clinical characteristics, and dobutamine stress echocardiography to optimize long-term cardiac management after major vascular surgery.
BACKGROUND
Survivors of major vascular surgery are at increased risk of late cardiac complications.


OBJECTIVE
To examine the cardioprotective effect of beta-blockers.


METHODS
A follow-up study was conducted in 1286 patients who survived surgery for at least 30 days. Patients were screened for cardiac risk factors and dobutamine stress echocardiography (DSE) results; 1034 patients (80%) underwent preoperative DSE, and 370 (29%) received beta-blockers. The main outcome measure was late cardiac death or myocardial infarction.


RESULTS
Seventy-four patients (5.8%) had late cardiac events. Cardiac event rates in patients with 0, 1 to 2, and 3 or more risk factors were 1.6%, 4.7%, and 19.2%, respectively. In patients without risk factors, beta-blockers were associated with improved event-free survival (2.8% vs 0%), and DSE had no additional prognostic value. In patients with 1 to 2 risk factors, the presence of ischemia during DSE increased cardiac events from 3.9% to 9.8%. However, if patients with ischemia were treated with beta-blockers, the risk decreased to 7.2%. In patients with 3 or more risk factors, DSE and beta-blockers stratified patients into intermediate- and high-risk groups. In patients without ischemia, beta-blockers reduced the cardiac event rate from 15.1% to 9.5%, whereas the cardioprotective effect was limited in patients with 3 or more risk factors and positive DSE findings.


CONCLUSIONS
Long-term beta-blocker use is associated with a reduction in the cardiac event rate, except for patients with 3 or more risk factors and positive findings on DSE.
Kertai
Miklos D
MD
Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Boersma
Eric
E
Bax
Jeroen J
JJ
Thomson
Ian R
IR
Cramer
Maarten J
MJ
van de Ven
Louis L M
LL
Scheffer
Michaël G
MG
Trocino
Giuseppe
G
Vigna
Carlo
C
Baars
Hubert F
HF
van Urk
Hero
H
Roelandt
Jos R T C
JR
Poldermans
Don
D
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000368:Aged; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000453:epidemiology / Q000628:therapy*; D025401:Echocardiography, Stress; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D011184:Postoperative Period; D012307:Risk Factors; D014652:Vascular Diseases / Q000453:epidemiology; D014656:Vascular Surgical Procedures
D000319:Adrenergic beta-Antagonists