title: [A study on genetic epidemiology of cerebral infarction].
abstract: OBJECTIVE
  To explore the genetic model of cerebral infarction and to examine the relationship between cerebral infarction and genetic factor.
  
  
  METHODS
  A matched case-control study including 112 pairs pedigrees was carried out. Using the Li-Mantel-Gart method and the Falconer method to estimate the segregation ratio and the heritability of cerebral infarction.
  
  
  RESULTS
  The prevalence rate of the first-degree and the second-degree relatives in cases was significantly higher than that in controls. The segregation ratio was 0.143 7 (0.113 0 - 0.174 4), significantly lower than 0.25, which showed that cerebral infarction did not possess the characteristics of monogenetic model. The results showed that the heritability of the first-degree and the second-degree relatives were 47.84% and 40.95% higher in male's than in female's.
  
  
  CONCLUSIONS
  Cerebral infarction was a polygenetic disease, and the genetic factors played an important role in the occurrence of cerebral infarction, especially in males.
authors.affiliation: The Public Health Section, Zhangjiakou Medical College, Zhangjiakou 075029, China.
authors.forename: Bao-lin
authors.initials: BL
authors.lastname: Shi
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yan-hua
authors.initials: YH
authors.lastname: Wu
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000453:epidemiology* / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence