Chemokines--their role in immunotherapy for intraocular inflammation.
Chemotactic cytokines are responsible for leukocyte migration and the immunopathogenesis of various inflammatory lesions. Together with other types of cytokines, chemokines play a major role in inducing/regulating inflammation and various immune responses. By targeting chemokines, immunotherapies could become another option for treating patients with uveitis. Indeed, a variety of chemokine-based therapies have been tested for their possible application for various pathological diseases, including intraocular inflammation. An example of chemokine-based therapy is anti-tumor necrosis factor (TNF)-alpha therapy, a very successful treatment. Chemokine- and cytokine-based therapies, therefore, appear to be a promising choice for the treatment of intraocular inflammation.
Kawashima
Hidetoshi
H
Department of Ophthalmology, University of Tokyo, Hongoln, Japan. hidemeali.thy@umin.ac.jp
D000818:Animals; D018925:Chemokines / Q000145:classification / Q000502:physiology / Q000627:therapeutic use*; D009877:Endophthalmitis / Q000188:drug therapy*; D006801:Humans; D007167:Immunotherapy; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
D018925:Chemokines; D014409:Tumor Necrosis Factor-alpha