title: Novel base-labile protecting groups for 5'-hydroxy function in solid-phase oligonucleotide synthesis.
abstract: The 6-(levulinyloxymethyl)-3-methoxy-2-nitrobenzoyl (LMMoNBz) and 2-(levulinyloxymethyl)-5-methoxy-4-nitrobenzoyl (LMMpNBz) groups were developed as novel base-labile protection for the 5'-hydroxy function in solid-phase oligonucleotide synthesis. A comparative study of the LMMoNBz, LMMpNBz and 2-(levulinyloxymethyl)-5-nitrobenzoyl (LMNBz) protecting groups for oligonucleotide synthesis proved strong feasibility for the LMMoNBz group.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan. kamaikek@ps.toyaku.ac.jp
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kamaike
authors.forename: Takashi
authors.initials: T
authors.lastname: Namiki
authors.forename: Etsuko
authors.initials: E
authors.lastname: Kawashima
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006900:Hydroxylation; D007202:Indicators and Reagents; D015394:Molecular Structure; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013941:Thymine
chemical_list: D007202:Indicators and Reagents; D009841:Oligonucleotides; D013941:Thymine