Modified release bi-layered tablet of melatonin using beta-cyclodextrin.
A modified release bi-layered tablet of melatonin incorporating a fast release fraction consisting of melatonin-beta-cyclodextrin inclusion complex and a slow release fraction containing melatonin in HPMC K15M and Carbopol 971 P matrices was prepared. The formulation developed showed an initial burst followed by a near zero order release pattern for a period of 8 h. The drug content, physical characteristics and the release profile were unaffected after 3 months of an accelerated stability study at 40 degrees C and 75% relative humidity.
Kumar
A
A
Department of Pharmaceutics, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, India.
Agarwal
S P
SP
Khanna
R
R
D000180:Acrylic Resins; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D003505:Cyclodextrins / Q000737:chemistry*; D003692:Delayed-Action Preparations; D004355:Drug Stability; D005079:Excipients; D007700:Kinetics; D007785:Lactose / Q000031:analogs & derivatives*; D008550:Melatonin / Q000008:administration & dosage* / Q000737:chemistry; D008747:Methylcellulose / Q000031:analogs & derivatives*; D008855:Microscopy, Electron, Scanning; D010078:Oxazines; D011145:Polyvinyls; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets; D047392:beta-Cyclodextrins
D000180:Acrylic Resins; D000975:Antioxidants; D003505:Cyclodextrins; D003692:Delayed-Action Preparations; D005079:Excipients; D010078:Oxazines; D011145:Polyvinyls; D013607:Tablets; D047392:beta-Cyclodextrins; C006912:carboxypolymethylene; D008747:Methylcellulose; C071191:MK 458; D007785:Lactose; D008550:Melatonin; C031215:betadex