Synthesis of carbocyclic analogues of MECA and NECA 1,2-disubstituted as potential adenosine receptor agonists.
A new class of 1,2-disubstituted carbocyclic nucleosides of MECA and NECA analogues was synthesized in good yield starting from (+/-) 6-azabicyclo[3.2.0]heptan-7-one.
Besada
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Departamento de Química Orgánica, Universidad de Vigo, Pontevedra, Spain.
González-Moa
M J
MJ
Terán
C
C
Teijeira
M
M
Santana
L
L
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D019830:Adenosine-5'-(N-ethylcarboxamide) / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D058906:Purinergic P1 Receptor Agonists; D011687:Purines / Q000138:chemical synthesis
D007202:Indicators and Reagents; D058906:Purinergic P1 Receptor Agonists; D011687:Purines; C046756:5'-N-methylcarboxamideadenosine; D019830:Adenosine-5'-(N-ethylcarboxamide); D000241:Adenosine