Tumor escape from immune response: mechanisms and targets of activity.
Immune system plays an important role in control of tumor progression. Effective antitumor immune response depends on close interaction of several elements of immune system. They include antigen-presenting cells, different subsets of T cells, B cells and NK cells. However, tumor cells developed a number of mechanisms to escape recognition and elimination by immune system. In this review we will discuss these mechanisms and address possible approaches to correct them.
Gabrilovich
Dmitry
D
H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA. dgabril@moffitt.usf.edu
Pisarev
Vladimir
V
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D000938:Antigen-Presenting Cells / Q000166:cytology / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D007157:Immunologic Surveillance; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology; D022423:Myeloid Cells / Q000166:cytology / Q000276:immunology; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology; D019139:Tumor Escape / Q000276:immunology*