Growth inhibition activity of thioacetal artemisinin derivatives against human umbilical vein endothelial cells.
Thioacetal artemisinin derivatives, in particular, 10alpha-phenylthiodihydroartemisinins (5), 10beta-benzenesulfonyl-9-epi-dihydroartemisinin (9) and 10alpha-mercaptodihydroartemisinin (11), exhibit good growth inhibition activity against HUVEC proliferation at the concentration level of 1 microM.
Oh
Sangtae
S
Department of Chemistry, Yonsei University, Wonju 220-710, South Korea.
Jeong
In Howa
IH
Shin
Woon-Seob
WS
Lee
Seokjoon
S
D000080:Acetals / Q000138:chemical synthesis* / Q000494:pharmacology; D037621:Artemisinins / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D003124:Colorimetry; D042783:Endothelial Cells / Q000187:drug effects*; D005260:Female; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology; D011247:Pregnancy; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013778:Tetrazolium Salts; D013844:Thiazoles; D014471:Umbilical Veins / Q000166:cytology / Q000187:drug effects
D000080:Acetals; D037621:Artemisinins; D007783:Lactones; D012717:Sesquiterpenes; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue; C075875:artemisin