title: [Discovery of Chlamydia trachomatis in the throat during diagnosis of secondary syphilis in an HIV+ patient].
abstract: BACKGROUND
  Chlamydia trachomatis (CT) pharyngitis has rarely been described in the literature. Studies in the last decade have shown a prevalence of less than 5%, with more women than men infected in the pharynx. Among homosexual men, only one study, conducted more than 5 years ago, detected the presence of CT in the throat (in one patient out of 13 tested).
  
  
  METHODS
  A 33 year-old homosexual man consulted for cutaneous lesions on the palms and the chest. Infected by HIV, he was taking antiretroviral therapy but no antibiotic prophylaxis. He admitted practising unprotected (insertive and receptive) fellatio with unknown partners. The lesions were those of secondary syphilis but the location of the chancre remained unknown. An enlarged screening for sexually transmitted infections detected the presence, through molecular amplification, of CT in the throat without further localisation (urethra, anus). After intramuscular injection of Extencillin and an 8-day-regimen of cycline, CT was no longer detected in the throat. The course of HIV infection did not appear modified by this infectious episode.
  
  
  CONCLUSIONS
  According to a review of the literature, the 4 most recent studies have not revealed CT in the throat of homosexuals although the bacteria was detected in the urethra of 3 to 4% of them. Chlamydia trachomatis is more frequently detected in the genital tract rather than the pharynx of women also screened in various localisations. These results must be tempered by the participant recruitment methods, diagnostic methods used, sample size and history of recent antibiotherapy. The pharyngeal mucosa might be less receptive to CT than the urethral mucosa. Association of CT pharyngitis with syphilis or its occurrence during HIV infection are not documented. The molecular amplification technique detects CT in the throat with sensitivity and specificity. A one-week regimen of cycline can cure this pharyngitis. Cost-effectiveness of screening for pharyngeal CT has not yet been assessed in persons 'at risk'.
authors.affiliation: Centre clinique et biologique des MST, Paris.
authors.forename: François
authors.initials: F
authors.lastname: Deniaud
authors.forename: Catherine
authors.initials: C
authors.lastname: Scieux
authors.forename: Edith
authors.initials: E
authors.lastname: Spindler
authors.forename: Michel
authors.initials: M
authors.lastname: Janier
mesh_terms: D000328:Adult; D002692:Chlamydia trachomatis / Q000302:isolation & purification*; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D008297:Male; D010614:Pharynx / Q000382:microbiology*; D013587:Syphilis / Q000150:complications / Q000175:diagnosis*