Transfer of 14C to prenatal and neonatal rats from their mothers exposed to 14C compounds by ingestion.
The transfer of 14C through placenta or milk was investigated and the radiation dose to fetal and newborn rats was estimated. Female rats at different gestational stages or after delivery were exposed to 14C in the form of sodium bicarbonate, thymidine and lysine by a single ingestion. Radioactivity in maternal tissues and conceptuses (placenta, fetal membrane and fetus) and in the newborn was determined at various times after ingestion. After exposure to these 14C compounds, there was no significant difference between the 14C concentration in the fetus and that in the maternal tissues, suggesting that the placenta has no effect in preventing or accelerating the placental transfer of 14C. The concentration and content of 14C in the fetus and newborn were, however, dependent on the chemical form of 14C and on the prenatal or neonatal stage at the time of ingestion. The result of the dose estimation showed that 14C-lysine gave significantly higher prenatal and neonatal doses than 14C-sodium bicarbonate or 14C-thymidine.
Takeda
H
H
National Institute of Radiological Sciences, Anagawa 4-9-1, Inage-ku, Chiba-shi, 263 Japan. h-takeda@nirs.go.jp
Fuma
S
S
Miyamoto
K
K
Kuroda
N
N
Inaba
J
J
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D002250:Carbon Radioisotopes / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D005260:Female; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D007774:Lactation / Q000502:physiology; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D008657:Metabolic Clearance Rate; D008895:Milk, Human / Q000378:metabolism*; D009928:Organ Specificity; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar
D002250:Carbon Radioisotopes