[Genetic polymorphism and risk of diseases induced by chemicals].
The response of the individuals to xenobiotics is various due to the genetic polymorphism, that is, most likely, the determinant factor of the susceptibility of the individuals to xenobiotics. Therefore, the risk of diseases taking cancers as an example is different in population. In this paper, progresses of genetic polymorphism of toxicant-metabolizing enzyme genes and DNA repair genes and, their effects on individuals' risk to diseases were briefly reviewed.
Zhang
Zhongbin
Z
School of Public Health, Fudan University, Shanghai 200032, China.
Xia
Zhaolin
Z
D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic; D015262:Xenobiotics / Q000378:metabolism / Q000633:toxicity*
D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase