title: Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-adenosylhomocysteine hydrolase.
abstract: Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
authors.forename: Hyung Ryong
authors.initials: HR
authors.lastname: Moon
authors.forename: Jae Gyu
authors.initials: JG
authors.lastname: Park
authors.forename: Dae Hong
authors.initials: DH
authors.lastname: Shin
authors.forename: Won Jun
authors.initials: WJ
authors.lastname: Choi
authors.forename: Kang Man
authors.initials: KM
authors.lastname: Lee
authors.forename: Hea Ok
authors.initials: HO
authors.lastname: Kim
authors.forename: Moon Woo
authors.initials: MW
authors.lastname: Chun
authors.forename: Hee-Doo
authors.initials: HD
authors.lastname: Kim
authors.forename: Joong Hyup
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D043383:Adenosylhomocysteinase / Q000009:adverse effects*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007700:Kinetics; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; C031096:neplanocin A; D043383:Adenosylhomocysteinase; D000241:Adenosine