Cortisol levels in the human perilymph after intravenous administration of prednisolone.
Cortisone is used in various inner ear disorders such as sudden hearing loss. However, it is not known if the doses of prednisolone employed in therapy increase the cortisol level in the inner ear. To evaluate the level of cortisol within the perilymph after intravenous administration of 125 and 250 mg of prednisolone, serum and perilymph samples of 29 consecutive patients with clinical otosclerosis subjected to stapedectomy were collected. Cortisol levels were determined by RIA. The perilymphatic cortisol level was significantly increased in the group with 250 mg of prednisolone while the perilymphatic cortisol levels were not significantly different between the control group and the patients treated with 125 mg. Although the therapeutic dose of prednisolone is not known, we conclude that the application of 250 mg has a greater impact on the inner ear than 125 mg.
Niedermeyer
Hans P
HP
Department of Otorhinolaryngology, Head and Neck Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
Zahneisen
Georg
G
Luppa
Peter
P
Busch
Raymonde
R
Arnold
Wolfgang
W
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010040:Otosclerosis / Q000188:drug therapy* / Q000601:surgery; D010498:Perilymph / Q000737:chemistry* / Q000187:drug effects; D011239:Prednisolone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011446:Prospective Studies; D012044:Regression Analysis; D013201:Stapes Surgery / Q000379:methods
D000893:Anti-Inflammatory Agents; D011239:Prednisolone; D006854:Hydrocortisone