Effect of potentially probiotic lactobacilli on faecal enzyme activity in minipigs on a high-fat, high-cholesterol diet-a preliminary in vivo trial.
Minipigs were fed a "Western-style", high-cholesterol diet for a baseline period, followed by the diet containing a mixture of three Lactobacillus strains with potential probiotic features, after which a normal pig diet was followed. The faecal enzyme activity for beta-glucuronidase and azoreductase, which are commonly considered as markers for procarcinogenic activity, was significantly reduced during the 5 weeks of "probiotic" supplementation. During the period of Lactobacillus administration, the cell counts for total anaerobes increased, whereas the total number of aerobes showed no change.
Haberer
P
P
Bundesforschungsanstalt für Ernáhrung, Institut für Hygiene und Toxikologie/BFE, Haid-und-Neu-Strasse 9, D-76131 Karlsruhe, Germany.
du Toit
M
M
Dicks
L M T
LM
Ahrens
F
F
Holzapfel
W H
WH
D000818:Animals; D002791:Cholesterol, Dietary / Q000008:administration & dosage* / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D005243:Feces / Q000201:enzymology*; D005966:Glucuronidase / Q000378:metabolism; D007778:Lactobacillus / Q000502:physiology*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D009601:Nitroreductases; D019936:Probiotics; D013552:Swine; D013556:Swine, Miniature / Q000382:microbiology*
D002791:Cholesterol, Dietary; D004041:Dietary Fats; D009247:NADH, NADPH Oxidoreductases; D009601:Nitroreductases; C021106:azoreductase; D005966:Glucuronidase