title: Multiple actions of systemic artemin in experimental neuropathy.
abstract: The clinical management of neuropathic pain is particularly challenging. Current therapies for neuropathic pain modulate nerve impulse propagation or synaptic transmission; these therapies are of limited benefit and have undesirable side effects. Injuries to peripheral nerves result in a host of pathophysiological changes associated with the sustained expression of abnormal pain. Here we show that systemic, intermittent administration of artemin produces dose- and time-related reversal of nerve injury-induced pain behavior, together with partial to complete normalization of multiple morphological and neurochemical features of the injury state. These effects of artemin were sustained for at least 28 days. Higher doses of artemin than those completely reversing experimental neuropathic pain did not elicit sensory or motor abnormalities. Our results indicate that the behavioral symptoms of neuropathic pain states can be treated successfully, and that partial to complete reversal of associated morphological and neurochemical changes is achievable with artemin.
authors.affiliation: Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA.
authors.forename: Luis R
authors.initials: LR
authors.lastname: Gardell
authors.forename: Ruizhong
authors.initials: R
authors.lastname: Wang
authors.forename: Chris
authors.initials: C
authors.lastname: Ehrenfels
authors.forename: Michael H
authors.initials: MH
authors.lastname: Ossipov
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Rossomando
authors.forename: Stephan
authors.initials: S
authors.lastname: Miller
authors.forename: Carolyn
authors.initials: C
authors.lastname: Buckley
authors.forename: Amber K
authors.initials: AK
authors.lastname: Cai
authors.forename: Albert
authors.initials: A
authors.lastname: Tse
authors.forename: Susan F
authors.initials: SF
authors.lastname: Foley
authors.forename: BangJian
authors.initials: B
authors.lastname: Gong
authors.forename: Lee
authors.initials: L
authors.lastname: Walus
authors.forename: Paul
authors.initials: P
authors.lastname: Carmillo
authors.forename: Dane
authors.initials: D
authors.lastname: Worley
authors.forename: Carol
authors.initials: C
authors.lastname: Huang
authors.forename: Thomas
authors.initials: T
authors.lastname: Engber
authors.forename: Blake
authors.initials: B
authors.lastname: Pepinsky
authors.forename: Richard L
authors.initials: RL
authors.lastname: Cate
authors.forename: Todd W
authors.initials: TW
authors.lastname: Vanderah
authors.forename: Josephine
authors.initials: J
authors.lastname: Lai
authors.forename: Dinah W Y
authors.initials: DW
authors.lastname: Sah
authors.forename: Frank
authors.initials: F
authors.lastname: Porreca
mesh_terms: D000818:Animals; D015415:Biomarkers; D015740:Calcitonin Gene-Related Peptide / Q000187:drug effects; D004399:Dynorphins / Q000187:drug effects; D008297:Male; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy*; D051381:Rats; D013127:Spinal Nerves / Q000187:drug effects / Q000293:injuries*
chemical_list: C490887:Artn protein, rat; D015415:Biomarkers; D009419:Nerve Tissue Proteins; D004399:Dynorphins; D015740:Calcitonin Gene-Related Peptide