Pancreatic resection for metastatic renal cell carcinoma: presentation, treatment, and outcome.
BACKGROUND
The diverse natural history of renal cell carcinoma (RCC) includes metastases to the pancreas, a very unusual site for distant spread of other cancers. Considering the relatively indolent behavior of some cases of metastatic RCC, pancreatic resection is offered to select patients.


METHODS
We reviewed the records of patients at three affiliated university hospital centers who had prior nephrectomy for RCC and subsequent pancreatic resection of metastases.


RESULTS
Fourteen patients--9 women and 5 men with a median age of 63.8 years--underwent a total of 15 pancreatic resections for metastatic RCC. Nine (64%) had solitary metastases. The median interval from nephrectomy to diagnosis of pancreatic metastases was 83 months. The median size of metastases was 4.6 cm. There was one perioperative death. Pancreatic recurrence occurred in five patients (36%), and one patient underwent repeat resection. At a median follow-up of 32 months, seven patients (50%) are alive without evidence of disease, and four patients (28%) are alive with recurrent disease.


CONCLUSIONS
Resection of pancreatic metastases from RCC is associated with long-term survival and should be considered for patients in whom complete resection is possible.
Law
Calvin H L
CH
Sunnybrook & Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
Wei
Alice C
AC
Hanna
Sherif S
SS
Al-Zahrani
Mohamed
M
Taylor
Bryce R
BR
Greig
Paul D
PD
Langer
Bernard
B
Gallinger
Steven
S
D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000556:secondary* / Q000601:surgery*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000556:secondary* / Q000601:surgery*; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome