Biopreparation of (-)-(1S,3R,4S,6S)-6-hydroxymenthol and (-)-(1S,3R,4S)-1-hydroxymenthol from 1-menthol by Rhizoctonia solani AG-1-IA and IB.
Microbial transformation of 1-menthol (1) by six isolates of soil-borne plant pathogenic fungi Rhizoctonia solani AG-1-IA (Rs24, Joichi-2 and RRG97-1) and AG-1-IB (TR22, R147 and 110.4) as a biocatalyst was investigated. Twenty one days precultivation of Rhizoctonia solani AG-1-IA Rs24 and AG-1-IB 110.4 showed excellent yield (98.5-98.6%) of (-)-(1S,3R,4S,6S)-6-hydroxymenthol (2) and (-)-(1S,3R,4S)-1-hydroxymenthol (3) from 1.
Miyazawa
Mitsuo
M
Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, Kowakae, Higashiosaka-shi, Osaka 577-8502, Japan. miyazawa@apch.kindai.ac.jp
Kawazoe
Hideki
H
Hyakumachi
Mitsuro
M
D000982:Antipruritics / Q000378:metabolism*; D001487:Basidiomycota / Q000201:enzymology*; D001711:Biotransformation; D008610:Menthol / Q000031:analogs & derivatives / Q000737:chemistry* / Q000378:metabolism*
C478836:(-)-(1S,3R,4S)-1-hydroxymenthol; C478835:(-)-(1S,3R,4S,6S)-6-hydroxymenthol; D000982:Antipruritics; D008610:Menthol