title: The uterine length in women with Turner syndrome reflects the postmenarcheal daily estrogen dose.
abstract: OBJECTIVE
  To evaluate the effects of estrogen substitution on the uterine development in patients with Turner syndrome.
  
  
  METHODS
  57 women, aged 18.1-41.5 years, were treated with estrogen from puberty induction.
  
  
  RESULTS
  In 21 women (37%), the uterus developed to >65 mm in length. The daily estrogen dose correlated with both uterine length (r = 0.29; p < 0.05) and Tanner breast stage (r = 0.44; p < 0.001). A negative correlation between age at artificial menarche and uterine length was found (r = -0.29; p < 0.05). The endometrium thickness was greater in women with an uterus length >65 mm (p < 0.05). In 50% of the women (18 were evaluated), an adult-shaped uterus developed. Previous growth hormone therapy (n = 32) had no impact on the uterus length.
  
  
  CONCLUSIONS
  The uterine development was suboptimal in most patients. Further investigation is needed to optimize estrogen therapy for uterine development in patients with Turner syndrome.
authors.affiliation: Endocrine Unit, 2nd Department of Paediatrics, 2nd Faculty of Medicine, University Hospital Motol, Prague, Czech Republic. marta.snajderova@lfmotol.cuni.cz
authors.forename: Marta
authors.initials: M
authors.lastname: Snajderova
authors.forename: Tonko
authors.initials: T
authors.lastname: Mardesic
authors.forename: Jan
authors.initials: J
authors.lastname: Lebl
authors.forename: Hedvika
authors.initials: H
authors.lastname: Gerzova
authors.forename: Leos
authors.initials: L
authors.lastname: Teslik
authors.forename: Jirina
authors.initials: J
authors.lastname: Zapletalova
mesh_terms: D000293:Adolescent; D000328:Adult; D001940:Breast / Q000187:drug effects / Q000254:growth & development; D003430:Cross-Sectional Studies; D036861:Delivery, Obstetric; D004305:Dose-Response Relationship, Drug; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008572:Menarche; D011247:Pregnancy; D014424:Turner Syndrome / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000503:physiopathology; D014463:Ultrasonography; D014599:Uterus / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000254:growth & development
chemical_list: D004967:Estrogens