title: The effects of anxiogenic stress on glucocorticoid sensitivity, glucose tolerance, and alloxan resistance in rats.
abstract: Four sessions of immobilization stress induced anxiogenic behavioral disorders in rats, which were accompanied by decreases in glucocorticoid sensitivity, increases in MAO-B activity in brain tissue, increases in tolerance to glucose loading, and decreases in resistance to acute hypoxia. Alloxan diabetes was accompanied by a decrease in behavioral activity of rats in the open field test, with an increase in cerebral MAO-B activity. Preceding anxiogenic stress increased the extent of the alloxan-induced increase in cerebral MAO-B activity and the accompanying abnormalities in the rats' behavior, and also potentiated the hyperglycemic effect of alloxan.
authors.affiliation: Department of General, Bioorganic Chemistry and Biochemistry ,Chelyabinsk State Medical Academy.
authors.forename: I A
authors.initials: IA
authors.lastname: Volchegorskii
authors.forename: V E
authors.initials: VE
authors.lastname: Tseilikman
authors.forename: S A
authors.initials: SA
authors.lastname: Ship
authors.forename: N V
authors.initials: NV
authors.lastname: Bubnov
authors.forename: A I
authors.initials: AI
authors.lastname: Sinitskii
mesh_terms: D000496:Alloxan / Q000494:pharmacology; D000818:Animals; D001007:Anxiety / Q000503:physiopathology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D005938:Glucocorticoids / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism; D008995:Monoamine Oxidase / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*
chemical_list: D005938:Glucocorticoids; D000496:Alloxan; D008995:Monoamine Oxidase; D005947:Glucose