Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas.
Five coumarins, isoimperatorin (1), pabulenol (2), isooxypeucedanin (3), oxypeucedanin hydrate (4) and osthol (5) were isolated from the MeOH extract of Angelica genuflexa in the course of searching for anti-platelet and anti-coagulant components from plants. Pabulenol (2) was isolated from A. genuflexa for the first time. The five compounds isolated from A. genuflexa, together with decursinol angelate (6), decursin (7) and nodakenin (8) from A. gigas were evaluated for their effects on platelet aggregation and blood coagulation. Compounds 2, 5, 6 and 7 were observed to be either equally effective or 2-4 times more inhibitory than ASA in both arachidonic acid and U46619 (TXA2 mimetic) induced platelet aggregations.
Lee
Yong Yook
YY
Natural Products Research Institute, Seoul National University, Seoul 110-460, Korea.
Lee
Sanghyun
S
Jin
Jing Ling
JL
Yun-Choi
Hye Sook
HS
D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid / Q000494:pharmacology; D029969:Angelica / Q000737:chemistry*; D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects; D002087:Butyrates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D011564:Furocoumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029001:Herbal Medicine; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D007723:Korea; D008297:Male; D008518:Medicine, East Asian Traditional; D000432:Methanol; D009391:Nephelometry and Turbidimetry / Q000379:methods; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D001578:Benzopyrans; D002087:Butyrates; D003374:Coumarins; D011564:Furocoumarins; D005960:Glucosides; D006575:Heterocyclic Compounds, 3-Ring; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; C055542:isoimperatorin; C487397:pabulenol; D016718:Arachidonic Acid; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D003094:Collagen; C101278:decursin; D001241:Aspirin; C031535:oxypeucadanin; C471579:nodakenin; C046627:osthol; C487398:isooxypeucedanin; D000432:Methanol