The Tat protein translocation pathway and its role in microbial physiology.
The Tat (twin arginine translocation) protein transport system functions to export folded protein substrates across the bacterial cytoplasmic membrane and to insert certain integral membrane proteins into that membrane. It is entirely distinct from the Sec pathway. Here, we describe our current knowledge of the molecular features of the Tat transport system. In addition, we discuss the roles that the Tat pathway plays in the bacterial cell, paying particular attention to the involvement of the Tat pathway in the biogenesis of cofactor-containing proteins, in cell wall biosynthesis and in bacterial pathogenicity.
Berks
Ben C
BC
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
Palmer
Tracy
T
Sargent
Frank
F
D000595:Amino Acid Sequence; D001419:Bacteria / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000502:physiology*; D026901:Membrane Transport Proteins / Q000502:physiology*; D008969:Molecular Sequence Data; D017510:Protein Folding; D021381:Protein Transport / Q000502:physiology*
D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; C408585:twin-arginine translocase complex, E coli