Toward transition metal-catalyzed carbonylation of methanol without HI as copromoter: catalytic exocyclic carbonylation of cycloimino esters.
[reaction: see text] Initial studies of a rare exocyclic C-O bond carbonylation are reported. Under the catalysis of Co(2)(CO)(8) in the absence of HI as the copromoter, cycloimino esters are carbonylated to afford N-acyllactams in high yields under relatively mild conditions (100-160 degrees C and 200-1000 psi). The reaction is interesting because it opens up the possibility of carbonylation of alcohols in the absence of HI.
Xu
Hongyu
H
Department of Chemistry, Lehigh University, 6 East Packer Avenue, Bethlehem, Pennsylvania 18015, USA.
Jia
Li
L