11q23-24 loss is associated with chromosomal instability in endometrial cancer.
A loss of the DNA copy number at chromosomal region 11q23-24 as detected by comparative genomic hybridization (CGH) is a marker of poor prognosis in patients with endometrial cancer. Malignant tumors display genetic instability, which is classified into two types: microsatellite instability (MIN) and chromosomal instability (CIN). In the present study, we examined whether there is a relation between loss of 11q23-24 and genetic instability in endometrial adenocarcinoma. Loss of 11q23-24 was detected in 4 of 70 endometrial cancers by fluorescence in situ hybridization (FISH), and DNA aneuploidy was detected by laser scanning cytometry (LSC) in 14 tumors. All tumors with 11q23-24 loss were aneuploid, and three of them were considered to have CIN. These findings suggest that 11q23-24 contains gene(s) necessary for normal chromosome replication and cell division.
Kawasaki
Keiko
K
Department of Obstetrics and Gynecology, Yamaguchi University School of Medicine, Ube, Yamaguchi 755-8505, Japan. obgyn@yamaguchi-u.ac.jp
Suehiro
Yutaka
Y
Umayahara
Kenji
K
Morioka
Hitoshi
H
Ito
Takehisa
T
Saito
Toshiaki
T
Tsukamoto
Naoki
N
Sugino
Norihiro
N
Kato
Hiroshi
H
Sasaki
Kohsuke
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000782:Aneuploidy; D043171:Chromosomal Instability / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D016889:Endometrial Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D011003:Ploidies
D004273:DNA, Neoplasm