Moebius sequence and hypogonadotrophic hypogonadism.
A distinct form of Moebius sequence is associated with hypogonadotrophic hypogonadism. There have been five such cases to date. We now add a further case with detailed neurologic, endocrine, and autopsy findings and offer a hypothesis drawing parallels with the already established basis of hypogonadotrophic hypogonadism in the X-linked form of Kallman syndrome.
Jennings
Juliet E
JE
Our Lady's Hospital for Sick Children, National Centre for Medical Genetics, Crumlin, Dublin, Ireland.
Costigan
Colm
C
Reardon
William
W
D003389:Cranial Nerve Diseases / Q000175:diagnosis; D006065:Gonadotropins, Pituitary / Q000172:deficiency*; D006801:Humans; D007006:Hypogonadism / Q000175:diagnosis*; D007223:Infant; D007231:Infant, Newborn; D017436:Kallmann Syndrome / Q000175:diagnosis; D008297:Male; D020331:Mobius Syndrome / Q000175:diagnosis*
D006065:Gonadotropins, Pituitary