Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction.
OBJECTIVE
To explore the frequency and significance of ApoE gene polymorphisms in Chinese patients with atherosclerotic cerebral infarction (ACI).


METHODS
Polymerase chain reaction and gene sequencing, single nucleotide polymorphisms of ApoE gene were used to analyze 33 cases of patients with ACI and 35 controls.


RESULTS
The frequencies of ApoE gene single nucleotide polymorphisms 465C/G, 462C/G and 451delC in the ACI group were significantly higher than those in the control group (P<0.05). The prevalence of polymorphism 486G/T in the control group was significantly higher than that in the ACI group (P=0.011).


CONCLUSIONS
465C/G,462C/G and 451delC polymorphisms might be associated with ACI.486GT allele might have protective effect on the pathogenesis of ACI.
Luo
Ben-yan
BY
Department of Neurology, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310003, China. lobenyan@263.net
Chen
Zhi
Z
Chen
Feng
F
Li
Xia
X
Pan
Xiao-ping
XP
D000368:Aged; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods
D001057:Apolipoproteins E