title: Hydrating effects of a corticoid oil formulation and its vehicle on human skin.
abstract: Factors in the treatment of atopic dermatitis include restoring skin moisture and reducing inflammation. This study evaluated a corticoid oil formulation and its components with respect to their skin hydration potential. Ten healthy Caucasians were enrolled. Five test sites on the left and right forearm of each subject were tested: one site served as a normal skin control (without treatment), whereas four were wetted by spraying distilled water (approximately 0.1 ml) over a 3-cm2 skin surface area, and spraying was repeated every 5 min for a total of three applications. Five minutes after the final application, 0.2 ml of the corticoid oil formulation, moisturizing vehicle, and plain peanut oil were applied to each pre-designated site (3 cm2); one site was kept as a blank control (water saturation only). Thirty minutes later, test sites were gently wiped with paper tissues, and visual scoring, transepidermal water loss (TEWL), and capacitance were recorded and repeated at 2 and 3 h. The corticoid oil formulation, plain peanut oil, and moisturizing vehicle significantly increased skin hydration 30 min after each single application, with no statistically significant difference among the treatments at any point. The corticoid oil formulation and plain peanut oil slightly but not significantly elevated TEWL 30 min after application. The results support intuitive dermatologic judgment of advising patients to apply moisturizing medicaments after bathing.
authors.affiliation: Department of Dermatology, University of California, School of Medicine, San Francisco, Calif. 94143-0989, USA.
authors.forename: H
authors.initials: H
authors.lastname: Zhai
authors.forename: R G
authors.initials: RG
authors.lastname: Ramirez
authors.forename: H I
authors.initials: HI
authors.lastname: Maibach
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D000328:Adult; D001698:Biomedical Engineering; D002626:Chemistry, Pharmaceutical; D025802:Electric Capacitance; D004890:Erythema / Q000139:chemically induced; D005260:Female; D006801:Humans; D006813:Humidity; D008297:Male; D008875:Middle Aged; D009821:Oils / Q000008:administration & dosage / Q000493:pharmacokinetics; D014677:Pharmaceutical Vehicles; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D014870:Water Loss, Insensible / Q000187:drug effects*
chemical_list: D000305:Adrenal Cortex Hormones; D009821:Oils; D014677:Pharmaceutical Vehicles