title: Molecular recognition of anions through hydrogen bonding stabilization of anion-ionophore adducts: a novel trifluoroacetophenone-based binding motif.
abstract: [reaction: see text] A novel trifluoroacetophenone-based binding motif has been developed that recognizes anions such as carboxylates through reversible formation of anion-ionophore adducts that are stabilized by intramolecular H-bonding. The intramolecular H-bonding resulted in more than 10-fold enhancement in the binding affinity and an enthalpy gain (DeltaH degrees ) of 3.0 kcal/mol for the binding of an acetate ion when compared to the case without the intramolecular H-bonding.
authors.affiliation: Department of Chemistry and Center for Integrated Molecular Systems, Division of Molecular and Life Science, Pohang University of Science and Technology, San 31 Hyoja-dong, Pohang 790-784, Republic of Korea.
authors.forename: Young Kook
authors.initials: YK
authors.lastname: Kim
authors.forename: Yun-Ho
authors.initials: YH
authors.lastname: Lee
authors.forename: Hyang-Yeol
authors.initials: HY
authors.lastname: Lee
authors.forename: Mi Kyoung
authors.initials: MK
authors.lastname: Kim
authors.forename: Geun Sig
authors.initials: GS
authors.lastname: Cha
authors.forename: Kyo Han
authors.initials: KH
authors.lastname: Ahn