Severe hemolysis due to passenger lymphocyte syndrome after hematopoietic stem cell transplantation from an HLA-matched related donor.
A 61-year-old white man (group A, Rh-positive) was allotransplanted for acute myelogenous leukemia from his HLA-matched related sister (group O, Rh-positive) in 2 separate infusions. Three days after the second graft infusion, the patient's front blood type converted to O Rh-positive, with a negative direct antiglobulin test and elevated anti-A1 titer. Severe hemolysis developed, and the patient expired 14 days posttransplantation.
Reed
Maria
M
Ohio State University Medical Center, Division of Transfusion Medicine, Columbus 43210-1228, USA.
Yearsley
Martha
M
Krugh
Dave
D
Kennedy
Melanie S
MS
D001402:B-Lymphocytes / Q000276:immunology; D006086:Graft vs Host Disease / Q000175:diagnosis* / Q000209:etiology* / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006461:Hemolysis / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007518:Isoantibodies / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D014019:Tissue Donors
D007518:Isoantibodies