title: Hemolytic anemia after renal transplantation: analysis of case reports.
abstract: Hemolysis after renal transplantation in some cases is clearly related to hemolytic-uremic syndrome (HUS) and usually attributed to cyclosporine (CsA) treatment. Acute hemolysis in other recipients is related to anti-erythrocyte autoantibodies. In most cases these patients have received ABO-compatible, although ABO-nonidentical, organs, mostly from O blood group donors. We report three cases of autoimmune hemolytic anemia after renal transplantation. Two patients (patients: 1 and 2; ABO-compatible, but nonidentical kidneys) suffered acute hemolysis in the third week after transplantation. One patient (patient 3: ABO-identical kidney) suffered a chronic, subclinical course of disease beginning 5 months after transplantation. The clinical picture of this disease was completely different from HUS. The existence of severe anemia (patients 1 and 2), hyperbilirubinemia (particularly high in patient 3), increased serum lactic dehydrogenase levels, and decreased serum haptoglobin in the presence of good graft function suggested an hemolytic anemia. In all patients the direct antiglobulin test was positive. The acute or chronic symptoms of hemolysis disappeared, at 2 and 5 weeks, respectively, after conversion from CsA to tacrolimus. Hemolysis in these patients probably relates to alloantibodies derived from passenger B lymphocytes transplanted with the organs. Because hemolysis has been most frequently related to CsA therapy, it is suggested that B lymphocytes proliferated and produced antibodies because CsA effects to inhibit T-cell function generally spares B-cell activity. It is proposed that a subtype of B cells, which are resistant to CsA, produces anti-A and/or anti-B antibodies. Treatment with tacrolimus appears to be successful, probably due to its alternate, and likely more effective, manner of B-cell suppression.
authors.affiliation: Department of Nephrology, Transplantology, and Internal Medicine, Medical University of Gdańsk, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Debska-Slizień
authors.forename: A
authors.initials: A
authors.lastname: Chamienia
authors.forename: E
authors.initials: E
authors.lastname: Król
authors.forename: Z
authors.initials: Z
authors.lastname: Zdrojewski
authors.forename: I
authors.initials: I
authors.lastname: Pirski
authors.forename: D
authors.initials: D
authors.lastname: Zadrozny
authors.forename: Z
authors.initials: Z
authors.lastname: Sledziński
authors.forename: B
authors.initials: B
authors.lastname: Rutkowski
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D000743:Anemia, Hemolytic / Q000175:diagnosis*; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000150:complications / Q000175:diagnosis; D016030:Kidney Transplantation / Q000009:adverse effects*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications
chemical_list: D000017:ABO Blood-Group System; D007770:L-Lactate Dehydrogenase