Cystein proteinase inhibitor stefin A as an indicator of efficiency of tumor treatment in mice.
The concentration of stefin A (cystatin A in mice) was measured in animals with experimental tumors (LS lymphosarcoma, HA-1-hepatoma, and Lewis lung carcinoma) during effective antitumor therapy. In mice with these tumors serum concentrations of stefin A increased, while the concentration of cystatin C (extracellular cystein proteinase inhibitor) decreased. The concentration of stefin A in tumor tissue in Lewis lung carcinoma was higher than in LS lymphosarcoma and HA-1-hepatoma ascitic cells, which can be explained by the degree of their malignancy. The content of stefin A in tumor tissue was similar to that in the liver and spleen of tumor-bearing animals, while its concentration in the liver and spleen of tumor-bearing animals was lower than in intact mice. The level of stefin A is an important marker of malignancy and an indicator of the efficiency of antitumor therapy.
Korolenko
T A
TA
Institute of Physiology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. T.A.Korolenko@iph.ma.nsc.ru
Poteryaeva
O N
ON
Falameeva
O V
OV
Levina
O A
OA
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002277:Carcinoma / Q000188:drug therapy; D006528:Carcinoma, Hepatocellular / Q000378:metabolism; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy; D055312:Cystatin A; D055316:Cystatin C; D015891:Cystatins / Q000096:biosynthesis* / Q000097:blood; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000188:drug therapy*; D013154:Spleen / Q000378:metabolism; D013997:Time Factors
D000970:Antineoplastic Agents; C525031:Cst3 protein, mouse; C501463:Csta1 protein, mouse; D055312:Cystatin A; D055316:Cystatin C; D015891:Cystatins; D015853:Cysteine Proteinase Inhibitors