Gating kinetics of potassium channel in rat dorsal root ganglion neurons analyzed with fractal model.
The kinetics of ion channels have been widely modeled as a Markov process. In these models it is assumed that the channel protein has a small number of discrete conformational states and kinetic rate constants connecting these states are constant. To study the gating kinetics of voltage-dependent K(+) channel in rat dorsal root ganglion neurons, K(+) channel current were recorded using cell-attached patch-clamp technique. The K(+) channel characteristic of kinetics were found to be statistically self-similar at different time scales as predicted by the fractal model. The fractal dimension D for the closed times and for the open times depend on the pipette potential. For the open and closed times of kinetic setpoint, it was found dependent on the applied pipette potential, which indicated that the ion channel gating kinetics had nonlinear kinetic properties. Thus, the open and closed durations, which had the voltage dependence of the gating of this ion channel, were well described by the fractal model.
Lan
Tong-Han
TH
Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China. ltham@163.com
Liu
Xiang-Ming
XM
Yuan
Hui-Jun
HJ
Lin
Jia-Rui
JR
D000818:Animals; D004594:Electrophysiology; D017709:Fractals; D005727:Ganglia, Spinal / Q000166:cytology* / Q000378:metabolism*; D015640:Ion Channel Gating; D007700:Kinetics; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism*; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D015221:Potassium Channels