Oxidation and degradation products of papaverine. Part II[1]: investigations on the photochemical degradation of papaverine solutions.
The structure of the final degradation product formed in papaverine solutions in either water or chloroform was found to be a 2, 3, 9, 10-tetramethoxy-12-oxo-12H-indolo [2, 1-a] isoquinolinylium salt (a dibenzo [b, g] pyrrocolonium derivative). Its formation from papaverine oxidation products that is papaverinol, papaveraldine, and papaverine-N-oxide chloroform solutions under the influence of UV light, was investigated and possible reaction pathways are discussed.
Girreser
Ulrich
U
Department of Pharmaceutical Chemistry, Christian-Albrechts-University, Kiel, Germany. girreser@pharmazie.uni-kiel.de
Hermann
Tadeusz W
TW
Piotrowska
Karolina
K
D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D007211:Indoles / Q000737:chemistry*; D010084:Oxidation-Reduction; D010208:Papaverine / Q000737:chemistry / Q000528:radiation effects*; D010782:Photolysis; D011806:Quinolinium Compounds / Q000737:chemistry*; D012996:Solutions
C480962:2, 3, 9, 10-tetramethoxy-12-oxo-12H-indolo(2, 1-a)isoquinolinylium salt; D007211:Indoles; D011806:Quinolinium Compounds; D012996:Solutions; D010208:Papaverine