Synthesis and antiviral evaluation of ribavirin congeners containing a hexitol moiety.
Several ribavirin congeners containing a hexitol moiety were prepared via ring opening of two different epoxides with the methylcarboxylate ester of triazole and further elaboration. Unfortunately, none of the newly synthesized compounds displayed appreciable antiviral activity.
Van Aerschot
A
A
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium. vanaerschot@rega.kuleuven.ac.be
Schepers
G
G
Busson
R
R
Neyts
J
J
De Clercq
E
E
Herdewijn
P
P
D000438:Alcohols; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D016174:Hepacivirus / Q000187:drug effects*; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D014230:Triazoles
D000438:Alcohols; D000998:Antiviral Agents; D007202:Indicators and Reagents; D014230:Triazoles; D012254:Ribavirin