Evaluation of the antiviral and antimicrobial activities of triterpenes isolated from Euphorbia segetalis.
A phytochemical reinvestigation of the whole plant of Euphorbia segetalis yielded five tetracyclic triterpenes: 3beta-hydroxy-cycloart-25-en-24-one (1), cycloart-25-ene-3beta,24-diol (2), cycloart-23-ene-3beta,25-diol (3), lanosta-7,9(11),24-trien-3beta-ol (4) and lanosta-7,9(11),24(31)-trien-3beta-ol (5). beta-acetoxy-cycloart-25-en-24-one (1a) and glutinol (6), lupenone (7), dammaranodienol (9), cycloartenol acetate (10), 24-methylenecycloartanol acetate (11) and beta-sitosterol (12), isolated previously, were evaluated for their antiviral activities against Herpes simplex virus (HSV) and African swine fever virus (ASFV). Lupenone exhibited strong viral plaque inhibitory effect against HSV-1 and HSV-2. The in vitro antifungal and antibacterial activities of la, cycloart-23-ene-3beta,25-diol, 3-acetate (3a) and 6-12 were also investigated.
Madureira
A M
AM
Faculdade de Farmácia de Lisboa, CECF, Av. das Forças Armadas, 1600-083 Lisboa, Portugal.
Ascenso
J R
JR
Valdeira
L
L
Duarte
A
A
Frade
J P
JP
Freitas
G
G
Ferreira
M J U
MJ
D000358:African Swine Fever Virus / Q000187:drug effects; D028481:Euphorbia / Q000737:chemistry*; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology*
D014315:Triterpenes