title: [Acute renal failure caused by VIP-secreting tumor].
abstract: A 74-year-old woman had secretory diarrhea, severe metabolic acidosis, hypokalemia, hypovolemia, and acute renal failure caused by a pancreatic vasoactive intestinal polypeptide (VIP)-secreting tumor. Vipoma is a rare neuroendocrine tumor. Morbidity and mortality are related to long-standing dehydration and electrolyte and acid-base disturbance resulting in acute renal failure. Diagnosis requires the documentation of large volumes of secretory diarrhea, elevated VIP plasma levels, and the localization of the VIP-secreting tumor. Metastases are present in 50% of patients at the time of diagnosis. Treatment includes correction of volume, electrolyte, and metabolic abnormalities; CVVH during ARF; pharmacotherapy to decrease gastrointestinal secretion; and surgical resection of the vipoma.
authors.affiliation: U.O. di Nefrologia ed Emodialisi, Azienda Ospedaliera Carlo Poma, Mantova, Italy. dialisi@ospedale.mantova.it
authors.forename: D
authors.initials: D
authors.lastname: Lambertini
authors.forename: E
authors.initials: E
authors.lastname: Bottini
authors.forename: E
authors.initials: E
authors.lastname: Talassi
authors.forename: R
authors.initials: R
authors.lastname: Tarchini
authors.forename: L
authors.initials: L
authors.lastname: Gaetti
authors.forename: A
authors.initials: A
authors.lastname: Bellomi
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000368:Aged; D005260:Female; D006801:Humans; D010190:Pancreatic Neoplasms / Q000150:complications*; D003969:Vipoma / Q000150:complications*