title: Indole-2-carboxamides as novel NR2B selective NMDA receptor antagonists.
abstract: A novel series of indole-2-carboxamide derivatives was prepared and identified as NR2B selective NMDA receptor antagonists. The influence of the number and position of OH groups on the indole skeleton as well as the substitution of the piperidine ring on the biological activity of the compounds was studied.
authors.affiliation: Gedeon Richter Ltd., POB 27, H-1475 Budapest 10, Hungary. i.borza@richter.hu
authors.forename: István
authors.initials: I
authors.lastname: Borza
authors.forename: Sándor
authors.initials: S
authors.lastname: Kolok
authors.forename: Anikó
authors.initials: A
authors.lastname: Gere
authors.forename: Eva
authors.initials: E
authors.lastname: Agai-Csongor
authors.forename: Béla
authors.initials: B
authors.lastname: Agai
authors.forename: Gábor
authors.initials: G
authors.lastname: Tárkányi
authors.forename: Csilla
authors.initials: C
authors.lastname: Horváth
authors.forename: Gizella
authors.initials: G
authors.lastname: Barta-Szalai
authors.forename: Eva
authors.initials: E
authors.lastname: Bozó
authors.forename: Csilla
authors.initials: C
authors.lastname: Kiss
authors.forename: Attila
authors.initials: A
authors.lastname: Bielik
authors.forename: József
authors.initials: J
authors.lastname: Nagy
authors.forename: Sándor
authors.initials: S
authors.lastname: Farkas
authors.forename: György
authors.initials: G
authors.lastname: Domány
mesh_terms: D001667:Binding, Competitive / Q000187:drug effects; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D010636:Phenols / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D011869:Radioligand Assay; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
chemical_list: D018691:Excitatory Amino Acid Antagonists; D007211:Indoles; C121001:NR2B NMDA receptor; D010636:Phenols; D010880:Piperidines; D016194:Receptors, N-Methyl-D-Aspartate; C109643:Ro 25-6981