title: Characteristic fragmentation behavior of phosphoamino acid conjugates with 3'-azido-3'-deoxythymidine by electrospray ionization tandem mass spectrometry.
abstract: The conjugates of phosphoamino acids with 3'-azido-3'-deoxythymidine were synthesized and their structures were determined by various spectral methods. In positive and negative ion electrospray mass spectrometry (ESI-MS), the fragmentation pathways were investigated in conjunction with tandem mass spectrometry (MS/MS). The results showed that there were very different characteristic fragment ions in the positive ion MS/MS spectra and the negative ion MS/MS spectra.
authors.affiliation: The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xiao
authors.forename: Yong
authors.initials: Y
authors.lastname: Ju
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Cui
mesh_terms: D015394:Molecular Structure; D019606:Phosphoamino Acids / Q000032:analysis* / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D015215:Zidovudine / Q000737:chemistry*
chemical_list: D019606:Phosphoamino Acids; D015215:Zidovudine