[Therapeutic effects of 3-dimensional conformal radiotherapy for small hepatocellular cancers and multi-factor analysis of the prognosis].
OBJECTIVE
To evaluate the therapeutic effects of 3-dimensional conformal radiation therapy (3-DCRT) for small hepatocellular carcinoma (HCCs) and to analyze the prognostic factors.


METHODS
Forty-two HCCs patients were treated with 3-DCRT and acute effects and survival rates were observed. Kaplan-Meier method was used for survival analysis, and Cox proportional hazard model adopted in multi-factor analysis.


RESULTS
No evidence of local failure was found in 83.3% of the patients at 3 months after the radiotherapy. The overall 1-, 2-, and 3-year survival rates were 100.00%, 90.48%, 78.57% respectively. Multivariate analysis revealed that the gender, number of tumors, and tumor size were the independent and statistically significant factors affecting the patients' survival (P<0.05).


CONCLUSIONS
3-DCRT is effective and feasible for treating non-operable HCCs, and the gender, number of tumors, and tumor size are the major factors affecting the survival of HCCs patients.
Wu
De-hua
DH
Department of Radiation Oncology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. wudh@fimmu.com
Chen
Long-hua
LH
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D020266:Radiotherapy, Conformal / Q000379:methods*; D015996:Survival Rate