title: [Infective endocarditis with a huge mitral vegetation related to atopic dermatitis and high serum level of infection-related antiphospholipid antibody: a case report].
abstract: A 24-year-old woman with atopic dermatitis was admitted to our hospital with fever. Echocardiography showed a huge vegetation attached to the posterior mitral commissure without mitral valve dysfunction. Blood culture identified methicillin-sensitive Staphylococcus aureus. The serum level of antiphospholipid antibody was elevated. A splenic infarction occurred on the second hospital day. Surgery to resect the residual mobile vegetation was performed uneventfully on the 6th hospital day. The postoperative course was uneventful, and the patient was discharged after 4 weeks of antibiotic therapy. Preservation of the mitral valve is rare in the face of virulent Staphylococcus infection and the presence of a huge mobile vegetation. These findings were apparently related to the high serum level of infection-related antiphospholipid antibody and atopic dermatitis.
authors.affiliation: St' Luke's International Hospital, Heart Center, Tokyo.
authors.forename: Masahide
authors.initials: M
authors.lastname: Harada
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Nishi
authors.forename: Shinjiro
authors.initials: S
authors.lastname: Tamura
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Iba
authors.forename: Kohei
authors.initials: K
authors.lastname: Abe
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Yanbe
authors.forename: Takehide
authors.initials: T
authors.lastname: Akimoto
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Takao
authors.forename: Sunao
authors.initials: S
authors.lastname: Watanabe
authors.forename: Noriaki
authors.initials: N
authors.lastname: Hayashida
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Koyanagi
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D003876:Dermatitis, Atopic / Q000150:complications* / Q000276:immunology; D004452:Echocardiography; D017548:Echocardiography, Transesophageal; D004697:Endocarditis, Bacterial / Q000209:etiology*; D005260:Female; D006801:Humans; D016106:Methicillin Resistance; D008943:Mitral Valve / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000209:etiology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification
chemical_list: D017152:Antibodies, Antiphospholipid