[Changes in adaptation-compensatory processes in the course of acute ischemic stroke (clinico-biochemical comparisons)].
OBJECTIVE
To study changes in some components of stress-realizing system (SRS) and stress-limiting system (SLS) characterizing compensatory mechanisms in acute disturbance of cerebral circulation (ADCC).


METHODS
The activities of SRS and SLS were assessed in 94 patients by changes in the concentrations of glutamate, aspartate, acid phosphatase for SRS and gamma-aminobutyric acid (GABA) for SLS, respectively.


RESULTS
After analysis of clinicobiochemical correlations the following clinical phases were singled out: subcompensation, moderate decompensation, severe decompensation and terminal. The phase conversion depended on quantitative changes of SRS and SLS activity. This enabled characterization of severity in certain time periods. Imbalance was revealed between SRS and SLS because of hyperactivation or hypoactivation of one of the above systems.


CONCLUSIONS
Imbalance between SRS and SLS converts stress-syndrome from nonspecific link of adaptation into a nonspecific link of the disease pathogenesis.
Matsko
M A
MA
Ivanova
N E
NE
D000135:Acid Phosphatase / Q000097:blood / Q000378:metabolism; D000208:Acute Disease; D000222:Adaptation, Physiological; D018846:Excitatory Amino Acids / Q000134:cerebrospinal fluid / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000134:cerebrospinal fluid / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D012720:Severity of Illness Index; D020521:Stroke / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism / Q000503:physiopathology*; D013385:Succinate Dehydrogenase / Q000097:blood / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000097:blood / Q000378:metabolism
D018846:Excitatory Amino Acids; D005680:gamma-Aminobutyric Acid; D013385:Succinate Dehydrogenase; D000135:Acid Phosphatase; D009638:Norepinephrine