Immunostimulating activity of synthetic bursopeptides.
Biologically active peptides bursopeptide-1 (Tyr-Glu-Glu) and bursopeptide-2 (Trp-Thr-Ala-Glu-Glu-Lys-Gln-Leu) from the bursa of Fabricius were isolated and synthesized. Bursopeptide-1 stimulated expression of B cell differentiation antigens in lymphocyte culture from patients with burns. Bursopeptide-2 produced a variety of effects and stimulated expression of differentiation antigens on T and B cells and natural killer cells. Bursopeptides can modulate the mechanisms of interleukin-2-mediated lymphocyte activation. Bursopeptides stimulated the immune response in mice with cyclophosphamide-induced immunodeficiency, which manifested in increased hemagglutinin and hemolysin titers and increased count of antibody-producing cells in the spleen.
Tsepelev
V L
VL
Department of Pathophysiology, Chita State Medical Academy.
Tsepelev
S L
SL
D000818:Animals; D000941:Antigens / Q000737:chemistry; D001402:B-Lymphocytes / Q000187:drug effects; D002060:Bursa of Fabricius / Q000378:metabolism*; D002454:Cell Differentiation; D002645:Chickens; D003520:Cyclophosphamide / Q000494:pharmacology; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D010455:Peptides / Q000737:chemistry / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects
D000941:Antigens; D010455:Peptides; D003520:Cyclophosphamide