title: Procalcitonin and C-reactive protein do not discriminate between febrile reaction to anti-T-lymphocyte antibodies and Gram-negative sepsis.
abstract: Treatment with antibodies against T-lymphocytes usually triggers a febrile response potentially mimicking or masking infection. Procalcitonin (PCT) is considered a sensitive and specific marker of systemic bacterial and fungal infection. It was the aim of this study to investigate the characteristics of PCT and C-reactive protein (CRP) during treatment with polyclonal or monoclonal anti-T-cell antibodies, in order to examine the ability of these parameters to distinguish between systemic bacterial infection and reaction to antibody treatment. Thus, 15 consecutive febrile episodes after T-cell antibody infusion without clinical signs of infection were compared with nine episodes of Gram-negative sepsis. After T-cell antibody infusion PCT and CRP serum levels increased to a similar extent as in Gram-negative sepsis. Therefore, during T-cell antibody treatment neither PCT nor CRP are adequate for differentiating between fever due to infection or to unspecific cytokine release.
authors.affiliation: Division of Paediatric Haematology/Oncology, Karl-Franzens-University, Graz, Austria. hansjuergen.dornbusch@uni-graz.at
authors.forename: H J
authors.initials: HJ
authors.lastname: Dornbusch
authors.forename: V
authors.initials: V
authors.lastname: Strenger
authors.forename: R
authors.initials: R
authors.lastname: Kerbl
authors.forename: H
authors.initials: H
authors.lastname: Lackner
authors.forename: W
authors.initials: W
authors.lastname: Schwinger
authors.forename: P
authors.initials: P
authors.lastname: Sovinz
authors.forename: C
authors.initials: C
authors.lastname: Urban
mesh_terms: D000293:Adolescent; D000906:Antibodies / Q000009:adverse effects* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000175:diagnosis; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D005334:Fever / Q000175:diagnosis / Q000209:etiology*; D006090:Gram-Negative Bacteria; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000628:therapy; D011498:Protein Precursors / Q000097:blood*; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000175:diagnosis*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000906:Antibodies; D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D015740:Calcitonin Gene-Related Peptide