Effect of transmural pressure on constrictor reactions of caudal artery in hypotensive and hypertensive rats.
Clipping of the abdominal aorta distally to the renal arteries produces a persistent decrease in blood pressure in hindquarter vessels by 35-40%. On week 6-7 postoperation, the reactions of the caudal artery perfused in vitro under constant pressure to norepinephrine were studied. At transmural pressure of 150 mm Hg, the vascular responses in hypotensive rats were reduced compared to those in normotensive control. By contrast, the responses of hypertensive vessels were more pronounced at 75 mm Hg even after deendothelization.
Vlasova
M A
MA
Laboratory of Cybernetics, A. V. Vishnevskii Institute of Surgery, Moscow, Russia. mariya-@mail.ru
Borovik
A S
AS
Timin
E N
EN
Tarasova
O S
OS
Rodionov
I M
IM
D000818:Animals; D001158:Arteries / Q000473:pathology*; D001794:Blood Pressure; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004727:Endothelium / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology; D006973:Hypertension / Q000473:pathology; D007022:Hypotension / Q000473:pathology; D009638:Norepinephrine / Q000378:metabolism / Q000494:pharmacology; D010477:Perfusion; D011312:Pressure; D051381:Rats; D017208:Rats, Wistar
D009638:Norepinephrine