title: Apoptosis in male germ cells in response to cyclin A1-deficiency and cell cycle arrest.
abstract: Male mice homozygous for a mutated allele of the cyclin A1 gene (Ccna1) are sterile due to a block in cell cycle progression before the first meiotic division. Meiosis arrest in Ccna1(-/-) spermatocytes is associated with desynapsis abnormalities, lowered MPF activity, and apoptosis as evidenced by TUNEL-positive staining. With time, adult testicular tubules exhibit severe degeneration: some tubules in the older animals are almost devoid of germ cells at various stages of spermatogenesis. The mechanisms by which the cells sense the cell cycle arrest and the regulation of the decision to undergo cell death are under investigation.
authors.affiliation: Department of Genetics & Development, Institute of Human Nutrition, Center for Reproductive Sciences, College of Physicians & Surgeons, Columbia University, 630 West 168th Street, New York, NY 10032, USA.
authors.forename: Glicella
authors.initials: G
authors.lastname: Salazar
authors.forename: Dong
authors.initials: D
authors.lastname: Liu
authors.forename: Ching
authors.initials: C
authors.lastname: Liao
authors.forename: Leah
authors.initials: L
authors.lastname: Batkiewicz
authors.forename: Rachel
authors.initials: R
authors.lastname: Arbing
authors.forename: Sanny S W
authors.initials: SS
authors.lastname: Chung
authors.forename: Karen
authors.initials: K
authors.lastname: Lele
authors.forename: Debra J
authors.initials: DJ
authors.lastname: Wolgemuth
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology; D019925:Cyclin A / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D056750:Cyclin A1; D005854:Germ Cells / Q000473:pathology*; D008297:Male; D000090204:Mesothelin; D051379:Mice; D016296:Mutagenesis; D013091:Spermatogenesis / Q000502:physiology
chemical_list: C503747:Ccna1 protein, mouse; D019925:Cyclin A; D056750:Cyclin A1; C000715528:Msln protein, mouse; D000090204:Mesothelin