title: Xenotransplantation of embryonic precursors of human myogenesis for the correction of dystrophinopathy in mice with hereditary muscular dystrophy.
abstract: Human embryonic myogenic precursors were transplanted into muscles of mdx mice with hereditary dystrophin-deficient muscular dystrophy. Transplantation induced the synthesis of human dystrophin. The number of dystrophin-positive fibers progressively decreased, however, some of them were preserved even 5 months after transplantation. Our results indicate that xenogeneic transplantation of embryonic myogenic precursors compensates the genetic defect in dystrophin-deficient mice.
authors.affiliation: Russian State Medical University, Moscow.
authors.forename: V N
authors.initials: VN
authors.lastname: Yarygin
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
authors.forename: V F
authors.initials: VF
authors.lastname: Sitnikov
authors.forename: M A
authors.initials: MA
authors.lastname: Stenina
authors.forename: A B
authors.initials: AB
authors.lastname: Kuznetsov
authors.forename: R A
authors.initials: RA
authors.lastname: Poltavtseva
authors.forename: L I
authors.initials: LI
authors.lastname: Krivov
authors.forename: D A
authors.initials: DA
authors.lastname: Voevodin
authors.forename: V I
authors.initials: VI
authors.lastname: Savchuk
authors.forename: A V
authors.initials: AV
authors.lastname: Revishchin
authors.forename: L I
authors.initials: LI
authors.lastname: Korochkin
authors.forename: M A
authors.initials: MA
authors.lastname: Aleksandrova
mesh_terms: D000818:Animals; D017690:Cell Transplantation; D004247:DNA / Q000378:metabolism; D004195:Disease Models, Animal; D016189:Dystrophin / Q000235:genetics / Q000378:metabolism; D004622:Embryo, Mammalian / Q000166:cytology*; D005091:Exons; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D018101:Mice, Inbred mdx; D009132:Muscles / Q000166:cytology*; D009136:Muscular Dystrophies / Q000235:genetics / Q000473:pathology*; D009137:Muscular Dystrophy, Animal / Q000235:genetics / Q000473:pathology*; D009154:Mutation; D016133:Polymerase Chain Reaction; D013997:Time Factors; D014183:Transplantation, Heterologous
chemical_list: D016189:Dystrophin; D004247:DNA