title: Insecticidal compounds against Drosophila melanogaster from Cornus officinalis Sieb. et Zucc.
abstract: Dimethyl malate (1) and 5-hydroxymethyl furfural (2) were isolated as insecticidal compounds by bioassay-guided fractionation from MeOH extract of the fruits of Cornus officinalis Sieb. et Zucc. Insecticidal activity against larvae of D. melanogaster was demonstrated: 1 and 2 gave the LC50 value of 6.15 and 11.8 micromol/mL of diet concentration, respectively. Acute toxicity against adults of D. melanogaster, 1 and 2 had the insecticidal activity, with the LD50 value of 21.5 and 34.0 microg/adult.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Engineering, Kinki University, 3-4-1, Kowakae, Higashiosaka-shi, Osaka 577-8502, Japan. miyazawa@apch.kindai.ac.jp
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Miyazawa
authors.forename: Jun
authors.initials: J
authors.lastname: Anzai
authors.forename: Jun
authors.initials: J
authors.lastname: Fujioka
authors.forename: Yukio
authors.initials: Y
authors.lastname: Isikawa
mesh_terms: D000818:Animals; D001681:Biological Assay; D029768:Cornus / Q000737:chemistry*; D004331:Drosophila melanogaster; D005662:Furaldehyde / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000633:toxicity*; D008298:Maleates / Q000302:isolation & purification / Q000633:toxicity*; D010936:Plant Extracts / Q000633:toxicity; D018675:Toxicity Tests
chemical_list: D008298:Maleates; D010936:Plant Extracts; C008046:5-hydroxymethylfurfural; D005662:Furaldehyde; C004780:dimethyl maleate