Novel modes of capillary electrophoresis for the determination of endocrine disrupting chemicals.
The synthesis and usage of a wide range of organic chemicals has increased dramatically over the last five decades. These compounds sometimes termed endocrine disrupting chemicals include agricultural pesticides, industrial solvents, dyes, plasticisers, detergents and heat exchangers. Concerns have been raised about the potential adverse effects of these compounds on humans and wildlife species. Our objectives are to develop a method to identify, using novel capillary electrophoretic techniques, the endocrine disrupting compounds that are reported to be present in environmental samples. The CE modes, capillary zone electrophoresis, micellar electrokinetic chromatography (MEKC), cyclodextrin-modified MEKC (CD-MEKC) and electroosmotic flow-suppressed CD-MEKC were investigated for the determination of a range of endocrine disrupting chemical compounds. This paper shows some initial results obtained.
Regan
Fiona
F
School of Chemical Sciences, Dublin City University, Glasnevin, Dublin 9, Ireland. fiona.regan@dcu.ie
Moran
Anne
A
Fogarty
Barbara
B
Dempsey
Eithne
E
D002021:Buffers; D002138:Calibration; D019075:Electrophoresis, Capillary / Q000379:methods*; D004702:Endocrine Glands / Q000187:drug effects*; D004785:Environmental Pollutants / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D010636:Phenols / Q000494:pharmacology
D002021:Buffers; D004785:Environmental Pollutants; D004967:Estrogens; D010636:Phenols