Histiocytic lesions involving the bone marrow.
Histiocytic lesions involving the bone marrow include a number of reactive and neoplastic disorders. This article discusses the morphologic, immunophenotypic, and genotypic features of a variety of diseases associated with histiocytes and/or monocytes. Lysosomal storage disorders and hemophagocytic syndromes are often first diagnosed by bone marrow examination. Granulomas involving the bone marrow may also be the first indication of a systemic disorder. Apart from acute and chronic monocytic leukemias, the bone marrow is rarely involved by malignant histiocytic disorders, of which Langerhans cell histiocytosis is the most common.
Chang
Karen L
KL
Department of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA. kchang@coh.org
Gaal
Karl K
KK
Huang
Qin
Q
Weiss
Lawrence M
LM
D001853:Bone Marrow / Q000473:pathology*; D005838:Genotype; D006644:Histiocytes / Q000473:pathology*; D015614:Histiocytosis / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D006801:Humans; D016130:Immunophenotyping