[Deep brain stimulation of the Vim nucleus of the thalamus in the treatment of parkinsonian tremor].
Deep brain stimulation (DBS) of the ventral intermediate thalamic nucleus (Vim) has been recently introduced by Benabid and his colleagues as a new surgical procedure in the treatment of tremor-dominant Parkinson's disease (PD). The advantage of DBS Vim over lesioning (thalamotomy) is its reversibility and adjustability with the same clinical effect, but without the need to make a destructive thalamic lesion. In this procedure high-frequency stimulation is employed to simulate a thalamic lesion using an implanted electrode connected to a subcutaneously placed neuropacemaker. Four patients with tremor-dominant PD were included in the study. There were 3 men and one women. Three stimulators were implanted in the left and one in the right cerebral hemisphere. The patients were evaluated using clinical scales, before and up to 24 months after surgery. Adverse effects associated with chronic Vim stimulation were mild and reversible. Chronic thalamic stimulation is effective for drug-resistance parkinsonian tremor suppression, with few adverse side-effects. The method results in a significant improvement of function.
Zabek
Mirosław
M
Kliniki Neurochirurgii CMKP, Wojewódzkiego Szpitala Bródnowskiego w Warszawie.
Sobstyl
Michał
M
Koziara
Henryk
H
D004599:Electric Stimulation Therapy / Q000295:instrumentation*; D005260:Female; D005684:Gait; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000175:diagnosis; D010300:Parkinson Disease / Q000628:therapy*; D012720:Severity of Illness Index; D013788:Thalamus / Q000502:physiology*; D020651:Ventral Thalamic Nuclei / Q000502:physiology*