title: Immunohistochemical analysis of protein gene product 9.5, a ubiquitin carboxyl-terminal hydrolase, during placental and embryonic development in the mouse.
abstract: Protein gene product 9.5 (PGP9.5) is expressed at high level in the neural and neuroendocrine systems. We investigated the localization and degree of expression of PGP9.5 in the developing mouse placenta and embryo at 6.5, 10.5 and 14 days of gestation using an immunohistochemical technique. At 6.5 days of gestation PGP9.5 was detected at various levels in decidual and primary trophoblast giant cells in the placenta, and in embryonic ectodermal cells in the embryo. At 10.5 and 14 days of gestation PGP9.5 was expressed at moderate to strong levels in neurons in the embryo, but rarely in the placenta. These findings suggest that the protein may play a significant role in implantation and placental development, and differentiation of embryonic ectoderm.
authors.affiliation: Department of Veterinary Pathology, Nippon Veterinary and Animal Science University, 1-7-1, Kyounan-cho, Musashino, Tokyo 180-8602, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sekiguchi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tanaka
authors.forename: Jungkee
authors.initials: J
authors.lastname: Kwon
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ishii
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kyuwa
authors.forename: Keiji
authors.initials: K
authors.lastname: Wada
authors.forename: Shinichirou
authors.initials: S
authors.lastname: Nakamura
authors.forename: Kimimasa
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D004475:Ectoderm / Q000201:enzymology; D005260:Female; D007150:Immunohistochemistry; D051379:Mice / Q000196:embryology*; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D013869:Thiolester Hydrolases / Q000032:analysis*; D043222:Ubiquitin Thiolesterase
chemical_list: D013869:Thiolester Hydrolases; D043222:Ubiquitin Thiolesterase