[Polymorphism of c-Ha-ras 3'VNTR in hydatidiform mole and its relationship with the development of postmolar tumor].
OBJECTIVE
To study the polymorphism of c-Ha-ras 3' variable number of tandem repeat (VNTR) and its relationship with development of postmolar tumor.


METHODS
The cases of hydatidiform mole (HM) were retrospectively analyzed by amplified fragment length polymorphism-polyacrylamide gel electrophoresis. The DNA origin of HM was determined by comparison with the parents' DNA amplified results.


RESULTS
Among the samples from 15 cases, DNA from only paternal origin was found in 2 cases. DNA from both parents was in 13 cases, and of these 13 cases, 2 were found to be had balanced DNA origin, 11 had more DNA form paternal origin than DNA from maternal origin.


CONCLUSIONS
The HM which has DNA from both parents origin and predominantly from paternal origin developed to postmolar tumor more frequently.
Wang
Fang
F
Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, 524001 PR China. wangfangkx@163.com
Kang
Xu
X
Chen
Bi
B
Pang
Jiang-ling
JL
Li
Ying-yong
YY
D024509:3' Flanking Region / Q000235:genetics; D004252:DNA Mutational Analysis / Q000379:methods; D004273:DNA, Neoplasm / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D011905:Genes, ras / Q000235:genetics*; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics*; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics*; D021141:Nucleic Acid Amplification Techniques; D011110:Polymorphism, Genetic; D011247:Pregnancy; D012189:Retrospective Studies; D014594:Uterine Neoplasms / Q000235:genetics*
D004273:DNA, Neoplasm