Therapeutic efficiency of dimephosphone and xydiphone in experimental pulse therapy with prednisolone.
Experiments on rats showed that pulse therapy with prednisolone (100 mg/kg intraperitoneally for 3 days) stimulated urinary excretion of hydroxyproline, increased the content of inorganic phosphorus, promoted the increase in the content of dienic conjugates and catalase activity, and decreased serum levels of MDA and ceruloplasmin. Ten-day treatment with dimephosphone (208 mg/kg) or xydiphone (45 mg/kg) after pulse therapy with prednisolone normalized urinary excretion of hydroxyproline and reduced the levels of dienic conjugates. Dimephosphone did not change, while xydiphone normalized the level of MDA decreased by prednisolone.
Valeeva
I Kh
IKh
Central Research Laboratory and Department of Pharmacology, Kazan State Medical University.
Ziganshina
L E
LE
Burnashova
Z A
ZA
Ziganshin
A U
AU
D000284:Administration, Oral; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D012968:Etidronic Acid / Q000494:pharmacology*; D005260:Female; D005938:Glucocorticoids / Q000378:metabolism / Q000494:pharmacology; D006909:Hydroxyproline / Q000378:metabolism / Q000652:urine; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010710:Phosphates; D010758:Phosphorus / Q000097:blood; D011239:Prednisolone / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D035703:Therapies, Investigational; D013997:Time Factors
D005938:Glucocorticoids; D009943:Organophosphorus Compounds; D010710:Phosphates; C049638:dimephosphon; D010758:Phosphorus; D008315:Malondialdehyde; D011239:Prednisolone; D002374:Catalase; D002570:Ceruloplasmin; D012968:Etidronic Acid; D006909:Hydroxyproline; D002118:Calcium