title: 4'-C-methyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides revisited.
abstract: In order to evaluate their antiviral properties, a series of 4'-C-methyl-beta-D-ribofuranosyl purine and pyrimidine nucleosides has been prepared. Unfortunately, none of these 4'-branched nucleosides showed any antiviral activity or cytotoxcity when tested against HIV, HBV, and Yellow Fever virus.
authors.affiliation: Laboratoire Coopératif Idenix-CNRS, Université Montpellier II, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Griffon
authors.forename: D
authors.initials: D
authors.lastname: Dukhan
authors.forename: C
authors.initials: C
authors.lastname: Pierra
authors.forename: S
authors.initials: S
authors.lastname: Benzaria
authors.forename: A G
authors.initials: AG
authors.lastname: Loi
authors.forename: P
authors.initials: P
authors.lastname: La Colla
authors.forename: J P
authors.initials: JP
authors.lastname: Sommadossi
authors.forename: G
authors.initials: G
authors.lastname: Gosselin
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis; D015195:Drug Design; D007202:Indicators and Reagents; D008745:Methylation; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D012266:Ribose
chemical_list: D000998:Antiviral Agents; D007202:Indicators and Reagents; D011684:Purine Nucleosides; D011741:Pyrimidine Nucleosides; D012266:Ribose