title: Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma.
abstract: Expression profiling has demonstrated that transcriptomes of primary malignancies differ from those in normal tissue. It is unknown, however, whether there exist "surrogate" transcriptional markers in peripheral blood mononuclear cells (PBMCs) of patients with solid tumors. We identified transcripts expressed differentially between PBMCs from renal cell carcinoma patients and normal subjects, some of which appear to reflect specific immune responses of circulating cells. We also identified small sets of predictor genes distinguishing PBMCs from renal cell carcinoma patients and normal volunteers with high accuracy. The present findings have important implications for diagnosis and future clinical pharmacogenomic studies of antitumor therapies.
authors.affiliation: Discovery Medicine, Wyeth Research, Cambridge, Massachusetts 02140, USA.
authors.forename: Natalie C
authors.initials: NC
authors.lastname: Twine
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Stover
authors.forename: Bonnie
authors.initials: B
authors.lastname: Marshall
authors.forename: Gary
authors.initials: G
authors.lastname: Dukart
authors.forename: Manuel
authors.initials: M
authors.lastname: Hidalgo
authors.forename: Walter
authors.initials: W
authors.lastname: Stadler
authors.forename: Theodore
authors.initials: T
authors.lastname: Logan
authors.forename: Janice
authors.initials: J
authors.lastname: Dutcher
authors.forename: Gary
authors.initials: G
authors.lastname: Hudes
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Dorner
authors.forename: Donna K
authors.initials: DK
authors.lastname: Slonim
authors.forename: William L
authors.initials: WL
authors.lastname: Trepicchio
authors.forename: Michael E
authors.initials: ME
authors.lastname: Burczynski
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000145:classification / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000235:genetics; D007680:Kidney Neoplasms / Q000097:blood* / Q000145:classification / Q000235:genetics*; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000096:biosynthesis / Q000097:blood / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger