In through the out door: nuclear localization of the regulators of G protein signaling.
The regulators of G protein signaling (RGS) are an extraordinary class of diverse multifunctional signaling proteins best known for their potent capacity to down-regulate the activity of Galpha subunits at the plasma membrane. In certain circumstances, some RGS proteins undergo translocation to the nucleus or plasma membrane from the cytoplasm. Translocation demonstrates a potentially dynamic alternative mechanism for Galpha subunit or effector regulation. The nuclear localization of the regulators of G protein signaling proteins further suggests these proteins possess even greater functional heterogeneity than that envisioned previously, as regulators of transcription and cell cycle control.
Burchett
Scott A
SA
National Institutes of Health, National Institute of Child Health and Human Development, Laboratory of Neural Connectivity, Bethesda, Maryland 20892, USA. burchets@mail.nih.gov
D021581:Active Transport, Cell Nucleus / Q000502:physiology; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism*; D010766:Phosphorylation; D020710:RGS Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D020710:RGS Proteins