[Synthesis, characterization and in vitro release of poly (succinimide-co-4-aminobutanoic acid) by acid-catalyzed polycondensation of L-aspartic acid and 4-aminobutanoic acid].
For the purpose of increasing the hydrophilicity of poly aspartic acid, a series of polymer of L-aspartic acid and 4-aminobutanoic acid with different ratios (mol/mol) were prepared. The copolymers were characterized by 13CNMR, DSC and x-ray. The confirmed the structures of the polymers. In-vitro tests of release at phosphate buffer saline, enzyme solution of trypsin and papain (37.0 degrees C, pH = 7.4) were carried out. The result indicated that the polymers could be degraded in some degree, and that 4-aminobutanoic acid segments accelerated the degradation rate of the polymers. Skin irritation test and systemic acute toxicity test were carried out, which showed that the polymer was a nontoxic biomedical material.
Liao
Zhiyin
Z
College of Medical Science, Zhejiang University, Hangzhou 310006.
Tang
Guping
G
D000818:Animals; D001224:Aspartic Acid / Q000737:chemistry*; D005260:Female; D006868:Hydrolysis; D008297:Male; D008422:Materials Testing; D051379:Mice; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D011817:Rabbits; D005680:gamma-Aminobutyric Acid / Q000737:chemistry*
D011108:Polymers; D001224:Aspartic Acid; D005680:gamma-Aminobutyric Acid