Thiated analogues of 2',3'-dideoxy-3'-fluorothymidine and their phosphorylated and phosphonylated derivatives: synthesis, interaction with HIV reverse transcriptase, and in vitro anti-HIV activity.
Miazga
A
A
Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland. jagoda@poczta.ibb.waw.pl
Felczak
K
K
Bretner
M
M
Siwecka
M A
MA
Piasek
A
A
Kulikowski
T
T
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D015224:Dideoxynucleosides; D006678:HIV / Q000187:drug effects*; D015658:HIV Infections / Q000097:blood; D006801:Humans; D015394:Molecular Structure; D063065:Organophosphonates; D010766:Phosphorylation; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D063065:Organophosphonates; D018894:Reverse Transcriptase Inhibitors; D013438:Sulfhydryl Compounds; C002854:alovudine