title: The incidence, predictors, and outcomes of early reinfarction after primary angioplasty for acute myocardial infarction.
abstract: OBJECTIVE
  We sought to identify the incidence, predictors, and clinical consequences of one-month reinfarction (RE-MI) in patients undergoing primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI).
  
  
  BACKGROUND
  One-month reinfarction after AMI significantly increases long-term mortality; however, little is known about the incidence and predictors of RE-MI in patients undergoing primary angioplasty.
  
  
  METHODS
  We analyzed data from 3,646 patients who underwent primary PCI in the Primary Angioplasty in Acute Myocardial Infarction (PAMI) studies. We studied the incidence, correlates, and clinical outcomes of 30-day RE-MI.
  
  
  RESULTS
  Reinfarction within one month of index hospitalization occurred in 77 (2.1%) of patients. In multivariate analysis, admission Killip class >1 (odds ratio [OR] 2.02, 95% confidence interval [CI] 1.09 to 3.76), left ventricular ejection fraction <50% (OR 2.49, 95% CI 1.30 to 4.74), final coronary stenosis >30% (OR 2.57, 95% CI 1.28 to 5.15), and presence of coronary dissection (OR 2.40, 95% CI 1.36 to 4.24) and thrombus (OR 2.36, 95% CI 1.23 to 4.53) on the final angiogram were independent correlates of RE-MI. One-month reinfarction was independently associated with death (OR 7.14, 95% CI 3.28 to 15.5) and ischemic target vessel revascularization (I-TVR) (OR 15.0, 95% CI 8.68 to 26.0) at six months.
  
  
  CONCLUSIONS
  We conclude that, although early RE-MI is uncommon in patients treated by primary PCI, it is a significant independent predictor of death and I-TVR at six months. Admission Killip class >1 and left ventricular systolic dysfunction were associated with higher incidence of RE-MI. Our results suggest that optimal revascularization during primary PCI may decrease RE-MI rates.
authors.affiliation: Cardiology Division, William Beaumont Hospital, Royal Oak, Michigan, USA.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Kernis
authors.forename: Kishore J
authors.initials: KJ
authors.lastname: Harjai
authors.forename: Gregg W
authors.initials: GW
authors.lastname: Stone
authors.forename: Lorelei L
authors.initials: LL
authors.lastname: Grines
authors.forename: Judith A
authors.initials: JA
authors.lastname: Boura
authors.forename: Michael W
authors.initials: MW
authors.lastname: Yerkey
authors.forename: William
authors.initials: W
authors.lastname: O'Neill
authors.forename: Cindy L
authors.initials: CL
authors.lastname: Grines
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000209:etiology / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D009519:New York City / Q000453:epidemiology; D016017:Odds Ratio; D011379:Prognosis; D012008:Recurrence; D012307:Risk Factors; D012720:Severity of Illness Index; D016019:Survival Analysis; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left