title: Left atrial thrombus formation on a CardioSeal Septal Occlusion device in a patient with elevated factor VIII: resolution with medical therapy.
abstract: We describe a case of thrombus formation on the left atrial disc of a CardioSeal Septal Occlusion device 14 days after transcatheter closure of a patent foramen ovale in a patient with a history of multiple cryptogenic strokes. Work-up to rule out the presence of a hypercoagulable state prior to device closure demonstrated an elevated factor VIII level. Medical therapy with heparin and aspirin was initiated, with subsequent clot resolution.
authors.affiliation: Division of Pediatric Cardiology, University of Louisville, Louisville, Kentucky 40202-3830, USA. mitch.recto@louisville.edu
authors.forename: Michael R
authors.initials: MR
authors.lastname: Recto
authors.forename: Walter
authors.initials: W
authors.lastname: Sobczyk
authors.forename: Terence
authors.initials: T
authors.lastname: Hadley
authors.forename: Thomas
authors.initials: T
authors.lastname: Yeh
mesh_terms: D001241:Aspirin / Q000627:therapeutic use*; D001778:Blood Coagulation Disorders / Q000150:complications*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D017548:Echocardiography, Transesophageal; D004864:Equipment and Supplies / Q000009:adverse effects*; D005169:Factor VIII; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006344:Heart Septal Defects, Atrial / Q000150:complications / Q000601:surgery*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents; D005169:Factor VIII; D006493:Heparin; D001241:Aspirin