Influence of human platelet antigen match on the success of stem cell transplantation after myeloablative conditioning.
Mismatches between donor and recipient for human platelet antigens (HPA) may affect the success of transplantation due to: (a) serving as minor histocompa-tibility antigens and therefore render recipients at risk for graft-versus-host disease (GvHD), (b) inhibition of thrombopoiesis due to platelet antibodies. We therefore evaluated the occurrence of GvHD and need of platelet support by prospective analysis of donor-recipient pairs (n=53) for HPA-1, -2, -3, and -5 allotypes and screening for platelet antibodies prior to transplantation and in weekly intervals until day 100 after transplantation. Neither the incidence of GvHD nor the onset of thrombopoiesis, nor the CCI after platelet transfusions, nor the frequency of platelet transfusions was affected by HPA mismatches. Settings of homozygous donors vs heterozygous recipients or homozygous recipients vs heterozygous donors were not associated with any adverse effects on the outcome of the transplantation. Thus, the HPA-match does not affect the success of transplantation.
Leitner
G C
GC
Clinic for Blood Group Serology and Transfusion Medicine, University of Vienna, Vienna, Austria.
Tanzmann
A
A
Stiegler
G
G
Kalhs
P
P
Greinix
H T
HT
Hoecker
P
P
Panzer
S
S
D000293:Adolescent; D000328:Adult; D016824:Antigens, Human Platelet / Q000276:immunology*; D016026:Bone Marrow Transplantation / Q000401:mortality*; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology / Q000401:mortality; D018380:Hematopoietic Stem Cell Transplantation / Q000401:mortality*; D006801:Humans; D015994:Incidence; D007519:Isoantigens / Q000276:immunology; D008297:Male; D008875:Middle Aged; D019653:Myeloablative Agonists / Q000008:administration & dosage*; D010976:Platelet Count; D017713:Platelet Transfusion; D011446:Prospective Studies; D017701:Reticulocyte Count
D016824:Antigens, Human Platelet; D007519:Isoantigens; D019653:Myeloablative Agonists