Pre and post treatment mucociliary function in allergic rhinitis in three different treatment modalities.
Allergic rhinitis causes an impairment of the mucociliary function in the nose. It is hoped that treatment of perennial allergic rhinitis would be able to revert mucociliary function to normal. This study aims to compare pre and post treatment mucociliary transport time in 3 different treatment modalities. Ninety-two newly diagnosed patients with allergic rhinitis were randomised into 3 groups and started on different treatment regimes. At the end of 8 weeks, the group treated with only intranasal beclomethasone showed some, though not significant, improvement in the mucociliary function. There were no changes in the mucociliary function in the other two groups treated with beclomethasone and loratidine or loratidine alone.
Lee
L M
LM
Department of Surgery, (Otorhinolaryngology), Faculty of Medicine, Universiti Putra Malaysia, Asrama Jururawat, Jalan Masjid, Hospital Kuala Lumpur, Jalan Pahang, 53000 Kuala Lumpur.
Gendeh
B S
BS
D000281:Administration, Intranasal; D000284:Administration, Oral; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001507:Beclomethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D039563:Histamine H1 Antagonists, Non-Sedating / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D017336:Loratadine / Q000008:administration & dosage / Q000627:therapeutic use*; D009079:Mucociliary Clearance / Q000187:drug effects* / Q000502:physiology*; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000503:physiopathology*; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D039563:Histamine H1 Antagonists, Non-Sedating; D017336:Loratadine; D001507:Beclomethasone