Structure of colloidal bismuth subcitrate (CBS) in dilute HCl: unique assembly of bismuth citrate dinuclear units ([Bi(cit)(2)Bi](2-)).
Colloidal bismuth subcitrate (CBS, De-Nol) has been used for several decades for the treatment of gastric and duodenal ulcers, and Helicobacter pylori infection together with antibiotics. The solubility of CBS in water is found to be dramatically affected by pH, from >70 mg/mL at pH 7 to only about 1 mg/mL at pH 3. CBS was crystallized in dilute HCl at pH 3, and unique assembly of three basic bismuth citrate dimeric units ([Bi(cit)2Bi]2-) leads to the formation of two-dimensional sheets and 3D polymer.
Li
Wei
W
Department of Chemistry, University of Hong Kong, Pokfulam Road, Hong Kong, PR China.
Jin
Lan
L
Zhu
Nianyong
N
Hou
Xuemei
X
Deng
Feng
F
Sun
Hongzhe
H
D000890:Anti-Infective Agents / Q000737:chemistry; D000897:Anti-Ulcer Agents / Q000737:chemistry; D018360:Crystallography, X-Ray; D019281:Dimerization; D006851:Hydrochloric Acid / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry*
D000890:Anti-Infective Agents; D000897:Anti-Ulcer Agents; D009942:Organometallic Compounds; C002791:bismuth tripotassium dicitrate; D006851:Hydrochloric Acid