Is there an evolutionary relationship between WARP (von Willebrand factor A-domain-related protein) and the FACIT and FACIT-like collagens?
We suggest that there is an evolutionary relationship between von Willebrand factor A-domain-related protein (WARP), and the fibril-associated collagen with interrupted triple helix (FACIT) and FACIT-like subfamilies of collagens. Data from a comparison of amino acid sequences, domain organisation and chromosomal location are consistent with the hypothesis that WARP and these collagens share a common collagen ancestor. In support of this is the observation that the WARP 3' coding region is GC-rich suggesting that this may represent the remnant of a triple helix protein domain which WARP has 'lost' during evolution.
Fitzgerald
Jamie
J
Murdoch Childrens Research Institute, University of Melbourne, Royal Children's Hospital, Parkville, Vic. 3052, Australia. fitzgerj@cryptic.rch.unimelb.edu.au
Bateman
John F
JF
D000818:Animals; D002874:Chromosome Mapping; D019143:Evolution, Molecular; D016326:Extracellular Matrix Proteins / Q000737:chemistry* / Q000235:genetics*; D024021:Fibril-Associated Collagens / Q000737:chemistry* / Q000235:genetics*; D006801:Humans; D051379:Mice; D008957:Models, Genetic; D005810:Multigene Family; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid
D016326:Extracellular Matrix Proteins; D024021:Fibril-Associated Collagens; C460760:VWA1 protein, human; C460761:WARP protein, mouse