New ent-kaurene-type diterpenoids possessing cytotoxicity from the New Zealand liverwort Jungermannia species.
Two new ent-kaurene-type and a new rearranged ent-kaurene-type diterpenoids possessing cytotoxicity against a human leukemia cell line have been isolated from the New Zealand liverwort Jungermannia species, together with previously known ent-kaurene-type diterpenoids. Their structures were established based on extensive NMR techniques.
Nagashima
Fumihiro
F
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Japan.
Kasai
Wakana
W
Kondoh
Masuo
M
Fujii
Makiko
M
Watanabe
Yoshiteru
Y
Braggins
John Edward
JE
Asakawa
Yoshinori
Y
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D035926:Hepatophyta; D006801:Humans; D009520:New Zealand; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity
D004224:Diterpenes; D045786:Diterpenes, Kaurane; D010936:Plant Extracts