Improved synthesis of 2'-amino-LNA.
2'-Amino-LNA phosphoramidite (10) was synthesised by means of a new strategy, which is convergent with the synthesis of 2'-oxy-LNA up until a late stage intermediate (1).
Christensen
Signe M
SM
Cureon A/S, Copenhagen, Denmark. smc@cureon.com
Rosenbohm
Christoph
C
Sørensen
Mads
M
Larsen
Lotte-Emilie
LE
Wengel
Jesper
J
Koch
Troels
T
D000577:Amides; D000588:Amines; D007202:Indicators and Reagents; D008968:Molecular Conformation; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis*; D010756:Phosphoric Acids
D000577:Amides; D000588:Amines; D007202:Indicators and Reagents; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; D010756:Phosphoric Acids; C477371:locked nucleic acid; C011067:phosphoramidic acid