title: Hypertonic saline for cerebral edema.
abstract: Raised intracranial pressure (ICP) is a major contributor to the mortality of many conditions encountered in a neurologic intensive care unit. Achieving a sustained reduction in ICP in patients with intracranial hypertension remains a challenge. Treatment with hyperosmolar agents is one of the few options that are available, and mannitol is currently the most commonly used agent. However, hypertonic saline solutions have recently emerged as a potentially safer and more efficacious alternative to mannitol.
authors.affiliation: Department of Neurology, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
authors.forename: Alexandros L
authors.initials: AL
authors.lastname: Georgiadis
authors.forename: José I
authors.initials: JI
authors.lastname: Suarez
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001929:Brain Edema / Q000188:drug therapy* / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000188:drug therapy; D006801:Humans; D006955:Hypernatremia / Q000139:chemically induced / Q000150:complications; D007427:Intracranial Pressure; D009422:Nervous System Diseases / Q000139:chemically induced; D012462:Saline Solution, Hypertonic / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D012462:Saline Solution, Hypertonic