title: Retinal involvement in dementia with Lewy bodies: a clue to hallucinations?
abstract: Visual hallucinations are a core feature of dementia with Lewy bodies. Their pathophysiology is not well understood, because neither clinical nor histological data have shown their basic mechanisms. Here, we report the presence of pale inclusions in the outer plexiform layer of the retina in a patient with dementia with Lewy bodies. These inclusions are related to cytoskeletal disorganization of the cones at ultrastructural level and modifications of the immunohistochemical pattern of distribution of synucleins in the retina. These modifications may participate in the visual impairment in dementia with Lewy bodies.
authors.affiliation: Department of Neuropathology, R. Salengro Hospital, CHRU, Lille Cedex, France. ca-maurage@chru-lille.fr
authors.forename: Claude-Alain
authors.initials: CA
authors.lastname: Maurage
authors.forename: Marie-Magdeleine
authors.initials: MM
authors.lastname: Ruchoux
authors.forename: Rob
authors.initials: R
authors.lastname: de Vos
authors.forename: Andrei
authors.initials: A
authors.lastname: Surguchov
authors.forename: Alain
authors.initials: A
authors.lastname: Destee
mesh_terms: D001921:Brain / Q000378:metabolism / Q000473:pathology; D005260:Female; D006212:Hallucinations / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D020961:Lewy Body Disease / Q000150:complications* / Q000473:pathology; D008854:Microscopy, Electron / Q000295:instrumentation / Q000379:methods; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism; D016874:Neurofibrillary Tangles; D019600:Neuropil Threads; D012160:Retina / Q000473:pathology* / Q000648:ultrastructure; D051843:Synucleins; D014795:Visual Pathways / Q000378:metabolism / Q000473:pathology
chemical_list: D009419:Nerve Tissue Proteins; D051843:Synucleins