title: Active hair bundle movements and the cochlear amplifier.
abstract: The "active process" is a term used to describe amplification and filtering processes that are essential for obtaining the exquisite sensitivity of hearing organs. Understanding the components of the active process is important both for our understanding of the normal physiology of hearing and because perturbations of the cochlear amplifier may lead to such maladies as threshold shifts (both temporary and permanent), tinnitus, sensorineural hearing loss and presbicusis. To date the cochlear amplifier has largely been attributed to outer hair cell electromotility; however, recent evidence suggests, that active properties of the hair bundle may also be important. Most likely both somatic motility and active hair bundle movements contribute to establishing the cochlear active process. This paper reviews recent evidence regarding known active processes in the hair bundle gating compliance, and fast and slow adaptation.
authors.affiliation: Neuroscience Center and Kresge Hearing Labs, Louisiana State Health Sciences Center, New Orleans 70112, USA. aricci@lsuhsc.edu
authors.forename: Anthony
authors.initials: A
authors.lastname: Ricci
mesh_terms: D000161:Acoustic Stimulation; D003051:Cochlea / Q000502:physiology*; D004594:Electrophysiology; D006198:Hair Cells, Auditory / Q000502:physiology*; D006309:Hearing / Q000502:physiology*; D006801:Humans