title: Angiopoietin-2 polymorphism in women with idiopathic recurrent miscarriage.
abstract: OBJECTIVE
  To investigate the relationship between idiopathic recurrent miscarriage and a polymorphism of the gene encoding for angiopoietin-2 (ANGPT2), an autochthonous modulator of angiogenesis during pregnancy.
  
  
  METHODS
  Prospective case control study.
  
  
  METHODS
  Academic research institution.
  
  
  METHODS
  One hundred thirty-one women with a history of three or more consecutive pregnancy losses before 20 weeks' gestation, and 125 healthy, postmenopausal controls with at least two live births and no history of pregnancy loss.
  
  
  METHODS
  Peripheral venous puncture.
  
  
  METHODS
  Polymerase chain reaction and restriction fragment length polymorphism analysis were performed to identify the different ANGPT2 alleles.
  
  
  RESULTS
  No association between mutant (mt) allele and the occurrence of idiopathic recurrent miscarriage was found. Between women with primary and secondary idiopathic recurrent miscarriage, no statistically significant differences with respect to allele frequencies were observed.
  
  
  CONCLUSIONS
  This is the first report on the ANGPT2 gene polymorphism in women with idiopathic recurrent miscarriage, demonstrating that the investigated polymorphism is not associated with idiopathic recurrent miscarriage in a white population.
authors.affiliation: Department of Gynecology and Obstetrics, University of Freiburg School of Medicine, Freiburg, Germany. pietrowski@frk.ukl.uni-freiburg.de
authors.forename: Detlef
authors.initials: D
authors.lastname: Pietrowski
authors.forename: Clemens
authors.initials: C
authors.lastname: Tempfer
authors.forename: Hertha
authors.initials: H
authors.lastname: Bettendorf
authors.forename: Bernd
authors.initials: B
authors.lastname: Bürkle
authors.forename: Fritz
authors.initials: F
authors.lastname: Nagele
authors.forename: Gertrud
authors.initials: G
authors.lastname: Unfried
authors.forename: Christoph
authors.initials: C
authors.lastname: Keck
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D000483:Alleles; D042702:Angiopoietin-2 / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D042702:Angiopoietin-2