title: Effects on blood pressure decrease in response to PAF of Impatiens textori MIQ.
abstract: A 35% EtOH extract of flowers of Impatiens textori MIQ. showed an inhibitory effect on blood pressure decrease in response to platelet activating factor (PAF) measured with a blood pressure monitoring system. Bioassay-guided fractionation of the 35% EtOH extract (IT) led to isolation of the flavones apigenin (1) and luteolin (3), which significantly inhibited blood pressure decrease in response to PAF. Their compounds and apigenin 7-glucoside (2), chrysoeriol (4), quercetin (5), quercetin 3-glucoside (6), kaempferol (7), kaempferol 3-glucoside (8) and kaempferol 3-rhamnosyldiglucoside (9) were also isolated from the flowers of I. textori for the first time. This study revealed that the flowers of I. textori might be a possible anti-allergy agent.
authors.affiliation: School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Ueda
authors.forename: Hisae
authors.initials: H
authors.lastname: Oku
authors.forename: Munekazu
authors.initials: M
authors.lastname: Iinuma
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ishiguro
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D035264:Flowers; D029069:Impatiens; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D010972:Platelet Activating Factor