title: Sequential exposure of Aspergillus fumigatus to itraconazole and caspofungin: evidence of enhanced in vitro activity.
abstract: We investigated the in vitro activity of sequential itraconazole and caspofungin against 10 isolates of Aspergillus fumigatus. Previous exposure of A. fumigatus to itraconazole resulted in dose-dependent enhanced effects of caspofungin and vice versa. Our finding suggests a preferential role for azole-caspofungin sequential combinations and merits further in vivo investigation.
authors.affiliation: Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA. dkontoyi@mdanderson.org
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Kontoyiannis
authors.forename: Russell E
authors.initials: RE
authors.lastname: Lewis
authors.forename: Michail S
authors.initials: MS
authors.lastname: Lionakis
authors.forename: Nathaniel D
authors.initials: ND
authors.lastname: Albert
authors.forename: Gregory S
authors.initials: GS
authors.lastname: May
authors.forename: Issam I
authors.initials: II
authors.lastname: Raad
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects*; D000077336:Caspofungin; D004334:Drug Administration Schedule; D004347:Drug Interactions; D054714:Echinocandins; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology*; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests / Q000379:methods; D010455:Peptides / Q000494:pharmacology*; D010456:Peptides, Cyclic
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010455:Peptides; D010456:Peptides, Cyclic; D017964:Itraconazole; D000077336:Caspofungin