title: Refractory adenosine-sensitive congenital His bundle tachycardia: response to calcium-channel blockers.
abstract: The congenital form of His bundle tachycardia is an uncommon pediatric arrhythmia. We report the case of a 7-year-old child with tachycardiomyopathy. The incessant arrhythmia, detected in infancy, was resistant to amiodarone and beta-blockers. During electrophysiologic study, the tachycardia converted to sinus rhythm with intravenous adenosine and diltiazem. Subsequently, the child is maintaining sinus rhythm on oral verapamil. Calcium-channel blockers should be considered for the treatment of this arrhythmia, which is often resistant to multiple antiarrhythmic drugs.
authors.affiliation: Care Hospital, The Institute of Medical Sciences, Nampally, Hyderabad.
authors.forename: K
authors.initials: K
authors.lastname: Sharada
authors.forename: C
authors.initials: C
authors.lastname: Narasimhan
authors.forename: K Nageshwar
authors.initials: KN
authors.lastname: Rao
authors.forename: B
authors.initials: B
authors.lastname: Soma Raju
mesh_terms: D000241:Adenosine / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D002036:Bundle of His / Q000002:abnormalities* / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002648:Child; D004110:Diltiazem / Q000627:therapeutic use; D004351:Drug Resistance / Q000187:drug effects; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008790:Metoprolol / Q000627:therapeutic use; D017180:Tachycardia, Ventricular / Q000175:diagnosis / Q000188:drug therapy*; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers; D004110:Diltiazem; D008790:Metoprolol; D000241:Adenosine