Drug hypersensitivity syndrome to carbamazepine and human herpes virus 6 infection: case report and literature review.
We describe a patient with a drug-induced hypersensitivity syndrome to carbamazepine and a concomitant active infection with human herpes virus 6 (HHV-6). The potential role of HHV-6 regarding the drug-induced hypersensitivity syndrome is discussed and the main clinical features of this potentially fatal adverse drug reaction are highlighted.
Zeller
A
A
Outpatient Dept. of Internal Medicine, University Hospital Basel, Switzerland.
Schaub
N
N
Steffen
I
I
Battegay
E
E
Hirsch
H H
HH
Bircher
A J
AJ
D000328:Adult; D001483:Base Sequence; D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D018570:Risk Assessment; D019349:Roseolovirus Infections / Q000150:complications / Q000175:diagnosis*; D012640:Seizures / Q000175:diagnosis / Q000188:drug therapy
D002220:Carbamazepine