title: Synthesis of 5-azacytidine nucleosides with rigid sugar moiety as potential antitumor agents.
abstract: The bicyclic 3'-O,5'-C-methylene-linked and 2'-O,5'-C-methylene-linked 5-azacytidine derivatives were readily synthesized from 1,2;5,6-di-O-isopropylidene-D-glucose and evaluated against several cancer cell lines.
authors.affiliation: College of Pharmacy, Seoul National University, Seoul, Korea. mwchun@snu.ac.kr
authors.forename: Moon Woo
authors.initials: MW
authors.lastname: Chun
authors.forename: Myong Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Hea Ok
authors.initials: HO
authors.lastname: Kim
authors.forename: Hee-Doo
authors.initials: HD
authors.lastname: Kim
authors.forename: Joong Hyup
authors.initials: JH
authors.lastname: Kim
authors.forename: Hyung Ryong
authors.initials: HR
authors.lastname: Moon
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001374:Azacitidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D001374:Azacitidine