title: A computational study of the urinary excretion rates for 339Pu using new ICRP internal dosimetry models.
abstract: A computational study of the urinary excretion rates for 239Pu has been carried out using a methodology which involved the solution of a complete compartmental model describing the biokinetic behaviour of inhaled plutonium aerosols in the human body. The methodology, after proper validation, was applied to investigate the dependence of urinary excretion rates for 239Pu on the transfer rates given in the complete compartmental model. For this purpose, the default values of the transfer/absorption rates were modified by factors of 2 and 4 and urinary excretion rates were computed on 1, 10, 100, 1000 and 10,000 d post-intake. The percentage variations in the urinary excretion rates as a result of the modified transfer rates were computed for exposures to Type M and S aerosols of 239Pu. These results facilitated the identification of parameters significantly affecting the short-term and long-term urinary excretion rates. In addition, time variations of the predicted ratios of 239Pu activity in daily urine to that in blood (excretion ratios) were studied for the three biokinetic models of plutonium: the ICRP 67 model, the modified ICRP 67 model with the compartment STI to urinary bladder removed and Luciani and Polig's model. All the computational results are presented and discussed in this paper.
authors.affiliation: Internal Dosimetry Division, Bhabha Atomic Research Centre, Mumbai-400 085, India. issingh@apsara.barc.ernet.in
authors.forename: I S
authors.initials: IS
authors.lastname: Singh
authors.forename: R C
authors.initials: RC
authors.lastname: Sharma
authors.forename: M C
authors.initials: MC
authors.lastname: Abani
mesh_terms: D000398:Air Pollution, Radioactive / Q000032:analysis*; D003198:Computer Simulation; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis*; D007391:International Cooperation; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D016273:Occupational Exposure / Q000032:analysis; D011005:Plutonium / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine*; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods* / Q000592:standards*; D012137:Respiratory System / Q000378:metabolism; D012958:Societies, Scientific
chemical_list: D011005:Plutonium