title: Risk factors of stroke mortality: a 40-year follow-up of the Corfu cohort from the Seven-Countries Study.
abstract: The present work evaluates several risk factors for stroke mortality based on a 40-year follow-up of the Corfu cohort from the Seven-Countries Study. The population studied in this analysis consisted of 529 rural men (49.7 +/- 5.7 years old) enrolled at 1961. The death rate at the end of follow-up was 87.1% (i.e. 461 deaths out of 529 participants). Of 529 cardiovascular-disease-free men at entry, 74 (14%) died because of hemorrhagic or thrombotic stroke. Age (HR=1.11/year, p<0.001), pulse pressure (HR=1.16/5 mm Hg, p<0.001), total serum cholesterol levels (HR=0.81/10 mg/dl, p<0.01) and presence of physical activity (HR=0.59, p<0.05), showed a statistically significant association with fatal stroke events. In conclusion, age, pulse pressure levels, physical activity (protective) and total serum cholesterol levels (protective) were significantly related with 40-year stroke mortality.
authors.affiliation: Cardiology Department, School of Medicine, University of Athens, Athens, Greece. d.b.panagiotakos@usa.net
authors.forename: Demosthenes B
authors.initials: DB
authors.lastname: Panagiotakos
authors.forename: Christina
authors.initials: C
authors.lastname: Chrysohoou
authors.forename: Christos
authors.initials: C
authors.lastname: Pitsavos
authors.forename: Alessandro
authors.initials: A
authors.lastname: Menotti
authors.forename: Anastasios
authors.initials: A
authors.lastname: Dontas
authors.forename: John
authors.initials: J
authors.lastname: Skoumas
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Stefanadis
authors.forename: Pavlos
authors.initials: P
authors.lastname: Toutouzas
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D006115:Greece / Q000453:epidemiology; D006801:Humans; D007391:International Cooperation; D007558:Italy / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D012307:Risk Factors; D020521:Stroke / Q000209:etiology* / Q000401:mortality*; D015996:Survival Rate; D013997:Time Factors; D014481:United States; D015022:Yugoslavia / Q000453:epidemiology