Commercial-scale synthesis of protected 2'-deoxycytidine and cytidine nucleosides.
Transformation of 2'-deoxyuridine and uridine analogs to protected 2'-deoxycytidine and cytidine analogs has been investigated by two different methods. First, traditional triazolation protocol and second p-nitrophenoxylation method. Our studies conclude that the triazolation method is better and suitable for commercial scale-up.
Divakar
Kikkeri J
KJ
Research and Development, Innovasynth Technologies (India) Limited, (Formerly a Division of Indian Organic Chemicals Limited), Khopoli District, Raigad, Maharashtra, India. divakj@yahoo.com
Sawant
Chitra M
CM
Mulla
Y A
YA
Zemse
Deepak V
DV
Sitabkhan
Sakina M
SM
Ross
Bruce S
BS
Sanghvi
Yogesh S
YS
D003562:Cytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008968:Molecular Conformation; D014230:Triazoles
D007202:Indicators and Reagents; D014230:Triazoles; D003841:Deoxycytidine; D003562:Cytidine