The optimizing action of the synthetic peptide Selank on a conditioned active avoidance reflex in rats.
The actions of the synthetic heptapeptide preparation Selank on learning and memory processes in rats with initially low levels of learning ability were compared with those in normal rats, using a method based on acquisition of a conditioned active avoidance reflex, with repeated administration of peptide 15 min before the start of training sessions for four days. The effects of Selank (300 microg/kg) were compared with the effects of the nootrope piracetam (400 mg/kg). These experiments showed that Selank significantly activated the learning process in rats with initially poor learning ability, with effects apparent after first dose on training day 1. The effect progressively increased on repeated administration of Selank: the total number of correct solutions increased and the number of errors decreased (p < 0.05). The maximum optimizing activity of Selank on learning in normal rats was seen on day 3 of repeated administration and training, i.e., after formation of the initial consolidation phase. The dynamic features of the development of the activating action of Selank and piracetam were described. Comparison of the results obtained here with data on the anti-anxiety actions of Selank suggested potential for its use in optimizing mnestic functions in conditions of elevated emotional tension.
Kozlovskii
I I
II
Science Research Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
Danchev
N D
ND
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects*; D004924:Escape Reaction / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D018697:Nootropic Agents / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D010889:Piracetam / Q000494:pharmacology; D011214:Practice, Psychological; D051381:Rats; D017208:Rats, Wistar
D018697:Nootropic Agents; D009842:Oligopeptides; C100827:TP 7; D010889:Piracetam