Octreotide in control of multiple liver metastases from gastrinoma.
The somatostatin analogue octreotide was effective in controlling systemic effects related to multiple liver metastases from a gastrinoma. A 61-year-old man underwent distal gastrectomy for gastrinoma in the duodenum, because a curative resection was not feasible due to metastases found in paraaortic lymph nodes during operation. Multiple liver metastases, associated with an increase in serum gastrin concentration, were found by magnetic resonance imaging 16 months after the operation. Although chemotherapy with dimethyltrizenoimidazole carboxamide was not effective, subcutaneous administration of octreotide was effective in controlling the growth of the liver metastases and in stabilizing serum gastrin. The patient now receives subcutaneous injections of octreotide, at 200 microg a day, twice a week, as an outpatient.
Saijo
Fumito
F
Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
Naito
Hiroo
H
Funayama
Yuji
Y
Fukushima
Kouhei
K
Shibata
Chikashi
C
Hashimoto
Akihiko
A
Kitayama
Taku
T
Nagao
Munenori
M
Matsuno
Seiki
S
Sasaki
Iwao
I
D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D015408:Gastrinoma / Q000188:drug therapy* / Q000556:secondary; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000473:pathology*; D015043:Zollinger-Ellison Syndrome / Q000150:complications
D018931:Antineoplastic Agents, Hormonal; D015282:Octreotide