title: Tertiary amines promoted synthesis of symmetrical 1,3-disubstituted ureas.
abstract: Symmetrical 1,3-disubstituted ureas and cyclic ureas have been synthesized from corresponding isocyanates and diisocyanates by a new versatile, simple and quick method in the presence of tertiary amines at room temperature. The method under investigation has several advantages over the existing techniques, as it is simple to carry out; does not require complicated equipment; work-up is simple, as it does not use expensive chemicals. Moreover, the yields are almost quantitative. It has a potential for commercial applications in pharmaceutical chemistry.
authors.affiliation: PCSIR Laboratories Complex, Off University Road, Karachi-75280, Pakistan.
authors.forename: Syed M Abdul
authors.initials: SM
authors.lastname: Hai
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Perveen
authors.forename: Rashid A
authors.initials: RA
authors.lastname: Khan
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Khanb
authors.forename: Nighat
authors.initials: N
authors.lastname: Afza
mesh_terms: D004345:Drug Industry; D017953:Isocyanates / Q000737:chemistry*; D013696:Temperature; D014508:Urea / Q000031:analogs & derivatives / Q000138:chemical synthesis*
chemical_list: D017953:Isocyanates; D014508:Urea