title: 5'-O-fluorosulfonylbenzoyl esters of purine nucleosides as potential inhibitors of NTPase/helicase and polymerase of Flaviviridae viruses.
abstract: Synthesis and interactions of guanosine, inosine and ribavirin 5'-fluorosulfonylbenzoyl esters with hepatitis C virus (HCV) and Flaviviruses NTPase/helicase and polymerase are described.
authors.affiliation: Laboratory of Antimetabolites, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warszawa, Poland. mbretner@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Bretner
authors.forename: S
authors.initials: S
authors.lastname: Schalinski
authors.forename: P
authors.initials: P
authors.lastname: Borowski
authors.forename: T
authors.initials: T
authors.lastname: Kulikowski
mesh_terms: D004265:DNA Helicases / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018067:Flaviviridae / Q000201:enzymology*; D043583:Nucleoside-Triphosphatase / Q000037:antagonists & inhibitors*; D011684:Purine Nucleosides / Q000494:pharmacology*; D011687:Purines / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D011684:Purine Nucleosides; D011687:Purines; D043583:Nucleoside-Triphosphatase; D004265:DNA Helicases