title: Downstream processing of proteins.
abstract: This review focuses on the recovery of proteins from fermented starting materials, covering developments that have appeared in the literature since 1979. The major subjects discussed include cell disruption and extraction, solid/liquid separations, chromatography, separations in solution, and finishing operations. While advances have occurred in every area, the greatest diversity of innovation has taken place in the fields of chromatography and tangential-flow filtration.
authors.affiliation: Genentech, Inc., South San Francisco, California 94080, USA.
authors.forename: T
authors.initials: T
authors.lastname: Becker
authors.forename: J R
authors.initials: JR
authors.lastname: Ogez
authors.forename: S E
authors.initials: SE
authors.lastname: Builder