Cell motility: deaf Drosophila keep the beat.
Intraflagellar transport is involved in the assembly of cilia and eukaryotic flagella. Two recent studies have shown that defects in intraflagellar transport prevent assembly of sensory cilia in Drosophila, leaving the fly deaf and uncoordinated. Surprisingly, the mutant sperm flagella have normal structure and motility.
Witman
George B
GB
Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA. George.Witman@umassmed.edu
D000818:Animals; D001693:Biological Transport, Active; D002465:Cell Movement / Q000502:physiology*; D002696:Chlamydomonas / Q000502:physiology; D002923:Cilia / Q000378:metabolism* / Q000502:physiology; D004330:Drosophila / Q000166:cytology / Q000502:physiology*; D005407:Flagella / Q000378:metabolism* / Q000502:physiology; D008297:Male; D009475:Neurons, Afferent / Q000166:cytology; D010940:Plant Proteins; D015800:Protozoan Proteins / Q000378:metabolism; D013094:Spermatozoa / Q000502:physiology*
C416363:IFT88 protein, Chlamydomonas; D010940:Plant Proteins; D015800:Protozoan Proteins