title: Hypothalamic digoxin, hemispheric chemical dominance, and interstitial lung disease.
abstract: The isoprenoid pathway produces three key metabolites--endogenous digoxin, dolichol, and ubiquinone. This was assessed in patients with idiopathic pulmonary fibrosis and in individuals of differing hemispheric dominance to find out the role of hemispheric dominance in the pathogenesis of idiopathic pulmonary fibrosis. All 15 cases of interstitial lung disease were right-handed/left hemispheric dominant by the dichotic listening test. The isoprenoidal metabolites--digoxin, dolichol, and ubiquinone, RBC membrane Na(+)-K+ ATPase activity, serum magnesium, tyrosine/tryptophan catabolic patterns, free radical metabolism, glycoconjugate metabolism, and RBC membrane composition--were assessed in idiopathic pulmonary fibrosis as well as in individuals with differing hemispheric dominance. In patients with idiopathic pulmonary fibrosis there was elevated digoxin synthesis, increased dolichol and glycoconjugate levels, and low ubiquinone and elevated free radical levels. There was also an increase in tryptophan catabolites and a reduction in tyrosine catabolites. There was an increase in cholesterol phospholipid ratio and a reduction in glycoconjugate level of RBC membrane in patients with idiopathic pulmonary fibrosis. Isoprenoid pathway dysfunction con tributes to the pathogenesis of idiopathic pulmonary fibrosis. The biochemical patterns obtained in interstitial lung disease are similar to those obtained in left-handed/right hemispheric chemically dominant individuals by the dichotic listening test. However, all the patients with interstitial lung disease were right-handed/left hemispheric dominant by the dichotic listening test. Hemispheric chemical dominance has no correlation with handedness or the dichotic listening test. Interstitial lung disease occurs in right hemispheric chemically dominant individuals and is a reflection of altered brain function.
authors.affiliation: Department of Neurology, Medical College Hospital, Trivandrum, Kerala, India.
authors.forename: Ravi Kumar
authors.initials: RK
authors.lastname: Kurup
authors.forename: Parameswara Achutha
authors.initials: PA
authors.lastname: Kurup
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D001923:Brain Chemistry; D002298:Cardenolides; D016022:Case-Control Studies; D004007:Dichotic Listening Tests; D004077:Digoxin / Q000097:blood / Q000378:metabolism*; D004286:Dolichols / Q000378:metabolism; D004292:Dominance, Cerebral; D005609:Free Radicals / Q000378:metabolism; D006001:Glycoconjugates / Q000378:metabolism; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism; D007031:Hypothalamus / Q000737:chemistry / Q000378:metabolism*; D007545:Isoproterenol / Q000378:metabolism; D008171:Lung Diseases / Q000145:classification / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000378:metabolism; D012503:Saponins / Q000097:blood; D014451:Ubiquinone / Q000378:metabolism
chemical_list: D002298:Cardenolides; D004286:Dolichols; D005609:Free Radicals; D006001:Glycoconjugates; D018377:Neurotransmitter Agents; D012503:Saponins; C034504:digoxin-like factors; D014451:Ubiquinone; D004077:Digoxin; D006903:Hydroxymethylglutaryl CoA Reductases; D000251:Adenosine Triphosphatases; D008274:Magnesium; D007545:Isoproterenol