title: [Interventional MR-mammography: manipulator-assisted large core biopsy and interstitial laser therapy of tumors of the female breast]].
abstract: The present study investigated the clinical application of magnetic resonance (MR)-guided breast interventions, such as manipulator-assisted large core breast biopsy (LCBB) inside a 1.5 T whole-body magnet and MR-guided interstitial laser therapy (ILT). Sixteen patients underwent LCBB and 1 additional patient underwent 4 sessions of ILT of a recurrent undifferentiated lymph node metastasis in the axilla using a Nd-YAG laser (1064 nm). Temperature changes of the tumor tissue during ILT were monitored using phase images of a gradient echo sequence (GRE) (TR/TE/FA = 25/12/30). In 5 patients the biopsy findings were histopathologically confirmed after open surgery. In 3 patients, the biopsy missed one tubular and one ductal carcinoma; one invasive carcinoma was underestimated. Eight patients with benign findings are still in the follow-up period. The heating zone during ILT was well delineated on subtracted phase images. No severe adverse events were observed with LCBB or ILT. MR-guided breast biopsies are feasible with the manipulator system inside a whole-body 1.5 Tesla MR scanner. GRE information is suitable for therapy monitoring during ILT within the tumor. Further studies are necessary to evaluate the accuracy of the manipulator system and the efficacy of ILT in the treatment of breast lesions.
authors.affiliation: Institut für Diagnostische und Interventionelle Radiologie, Friedrich-Schiller-Universität Jena. stefan.pfleiderer@med.uni-jena.de
authors.forename: Stefan O
authors.initials: SO
authors.lastname: Pfleiderer
authors.forename: Jürgen R
authors.initials: JR
authors.lastname: Reichenbach
authors.forename: Susanne
authors.initials: S
authors.lastname: Wurdinger
authors.forename: Christiane
authors.initials: C
authors.lastname: Marx
authors.forename: Martin G
authors.initials: MG
authors.lastname: Freesmeyer
authors.forename: Jörg
authors.initials: J
authors.lastname: Vagner
authors.forename: Harald
authors.initials: H
authors.lastname: Fischer
authors.forename: Achim
authors.initials: A
authors.lastname: Schneider
authors.forename: Werner A
authors.initials: WA
authors.lastname: Kaiser
mesh_terms: D000368:Aged; D001706:Biopsy / Q000379:methods*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D006801:Humans; D028022:Low-Level Light Therapy; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008327:Mammography / Q000379:methods*; D008991:Monitoring, Physiologic / Q000379:methods