title: [Heparin resistance during cardiopulmonary bypass].
abstract: A 74-year-old man was scheduled for coronary artery bypass graft surgery with cardiopulmonary bypass. After intravenous heparin (200 U.kg-1), the activated clotting time (ACT) increased from 124 to 436 sec. However, it decreased to 128 sec immediately after cardiopulmonary bypass. The bypass was discontinued because the addition of heparin (200 U.kg-1) proved heparin resistance. The coronary artery bypass procedure was completed uneventfully without cardiopulmonary bypass. Several recent articles have reported that heparin resistance was corrected with antithrombin III concentrates, fresh frozen plasma, or argatroban. In this case, these drugs could not be used because the mechanism of heparin resistance remains uncertain. Thus, the off-pump technique is useful for unknown heparin resistance.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Jichi Medical School, Tochigi 329-0498.
authors.forename: Ryoko
authors.initials: R
authors.lastname: Maeda
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Fukuda
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nakaigawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hiruta
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hirabayashi
authors.forename: Norimasa
authors.initials: N
authors.lastname: Seo
mesh_terms: D000368:Aged; D000758:Anesthesia; D000925:Anticoagulants / Q000008:administration & dosage; D020152:Antithrombin III Deficiency; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D023921:Coronary Stenosis / Q000601:surgery; D004351:Drug Resistance; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D008297:Male; D014914:Whole Blood Coagulation Time
chemical_list: D000925:Anticoagulants; D006493:Heparin