title: Preparation of 6-thioguanosine phosphoramidite for oligoribonucleotide synthesis.
abstract: 6-Thioguanosine phosphoramidite was prepared, using 2,4-dinitrophenyl as protection group for thio-function, and its stability towards conditions of RNA synthesis was investigated. The results show that the monomer was stable under the conditions of RNA synthesis and suitable for incorporation of thioguanine into oligoribonucleotides.
authors.affiliation: School of Life and Health Sciences, Aston University, Birmingham, England.
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Eric
authors.initials: E
authors.lastname: Lattmann
authors.forename: Qinguo
authors.initials: Q
authors.lastname: Zheng
mesh_terms: D000577:Amides / Q000737:chemistry; D004355:Drug Stability; D006151:Guanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D015394:Molecular Structure; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D010756:Phosphoric Acids / Q000737:chemistry; D013872:Thionucleosides / Q000138:chemical synthesis*
chemical_list: D000577:Amides; D007202:Indicators and Reagents; D009843:Oligoribonucleotides; D010756:Phosphoric Acids; D013872:Thionucleosides; D006151:Guanosine; C011067:phosphoramidic acid; C005783:6-thioguanosine