title: Complete genome sequence and phylogenetic analysis of hepatitis B virus (HBV) isolates from patients with chronic HBV infection in Korea.
abstract: Although there is a report of high rate of hepatitis B virus (HBV) infection in South Korea, only a few entire genome sequences of HBV isolates from Korea have been reported. To obtain the complete nucleotide sequence of the Korean HBV, viral DNA was extracted from sera of Korean patients with chronic HBV infection who have not been exposed to any antiviral treatment. Complete genomic sequences were determined on three Korean HBV isolates. The entire genomic length of Korean HBV isolates, designated as KUHB84, KUHB81, and KUHB95, was 3,215 base pairs. No deletions and insertions were observed. Core promoter mutations (T1762/A1764) were detected in two isolates, KUHB84 and KUHB95. Phylogenetic analysis based on the entire genomic sequences showed that the Korean HBV isolates were genotype C and related closely to the Japanese HBV.
authors.affiliation: Department of Microbiology, College of Medicine, Korea University, Seoul, Korea.
authors.forename: Zagaa
authors.initials: Z
authors.lastname: Odgerel
authors.forename: Kyung Bo
authors.initials: KB
authors.lastname: Nho
authors.forename: Ju Young
authors.initials: JY
authors.lastname: Moon
authors.forename: Sun Ho
authors.initials: SH
authors.lastname: Kee
authors.forename: Kwang Sook
authors.initials: KS
authors.lastname: Park
authors.forename: Ki-Joon
authors.initials: KJ
authors.lastname: Song
authors.forename: Luck Ju
authors.initials: LJ
authors.lastname: Baek
authors.forename: Jong Eun
authors.initials: JE
authors.lastname: Yeon
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Byun
authors.forename: Chang Hong
authors.initials: CH
authors.lastname: Lee
authors.forename: Jin-Won
authors.initials: JW
authors.lastname: Song
mesh_terms: D019943:Amino Acid Substitution; D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D016679:Genome, Viral; D006515:Hepatitis B virus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D019694:Hepatitis B, Chronic / Q000821:virology*; D006801:Humans; D007723:Korea; D008969:Molecular Sequence Data; D009154:Mutation; D010802:Phylogeny; D011401:Promoter Regions, Genetic; D014764:Viral Proteins / Q000235:genetics
chemical_list: D004279:DNA, Viral; D014764:Viral Proteins