title: A relationship between Matrix metalloproteinase-1 (MMP-1) promoter polymorphism and cervical cancer progression.
abstract: Single nucleotide polymorphism (SNP) of the promoter region of MMP-1 (at -1607 bp) creates Ets binding sites, and correlations between this SNP and cancer susceptibility have been reported for various cancers. In this study, we genotyped the SNP in 23 cervical intraepithelial neoplasias (CIN) and 86 cervical cancer specimens. We found a correlation between promoter polymorphism and MMP-1 expression, and that this SNP was correlated with the clinical stage of cervical cancer. These findings suggested that SNP of MMP-1 promoter might influence the ability in cervical cancer invasion via transcriptional activity of this gene.
authors.affiliation: Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo, 060-0061, Hokkaido, Japan.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Nishioka
authors.forename: Satoru
authors.initials: S
authors.lastname: Sagae
authors.forename: Akira
authors.initials: A
authors.lastname: Nishikawa
authors.forename: Shin ichi
authors.initials: Si
authors.lastname: Ishioka
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kudo
mesh_terms: D001483:Base Sequence; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D020781:Matrix Metalloproteinase 1 / Q000032:analysis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D014407:Tumor Cells, Cultured; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000473:pathology
chemical_list: D020781:Matrix Metalloproteinase 1