title: Performance evaluation of the Abbott Cell-Dyn 1800 automated hematology analyzer.
abstract: The Cell-Dyn 1800 is a new automated hematology analyzer that provides an 18-parameter blood count and operates at a throughput of 60 specimens per hour. (Clinical significance has not been established for plateletcrit and platelet distribution width; therefore these parameters are not reportable in the United States.) The instrument is smaller than its predecessor and offers a variety of enhanced features, including increased patient data storage, availability of a bar code reader, and a cyanide-free reagent system. Our study comprehensively assessed the analytical characteristics of the instrument in a variety of areas. When applicable the requirements of appropriate NCCLS guideline documents were followed. Instrument background and carryover were shown to be consistent with the performance specification. Accuracy was demonstrated by linearity studies and by comparison of results from the automated blood count parameters of the Cell-Dyn 1700 and from the manual differential method. The instrument-generated results and morphology flags were found to be effective in screening for abnormalities demonstrated by manual morphological assessment. Precision of the Cell-Dyn 1800 instrument was studied over the short term (with fresh blood) as well as the long term with stabilized quality control material. In either case, the instrument exhibited satisfactory performance. The blood count parameters showed acceptable stability during storage experiments, although in the case of mean platelet volume, the Cell-Dyn 1800 results increased during the first 6 hours of storage, reflecting the morphological changes expected of platelets from EDTA-anticoagulated specimens.
authors.affiliation: Abbott Diagnostics Division, Santa Clara, California 95054, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Kendall
authors.forename: Ellen
authors.initials: E
authors.lastname: Benoit
authors.forename: Jean
authors.initials: J
authors.lastname: Bogiages
authors.forename: Richard
authors.initials: R
authors.lastname: Bordenkircher
authors.forename: Kim
authors.initials: K
authors.lastname: Caple
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Chen
authors.forename: Tony
authors.initials: T
authors.lastname: Cheng
authors.forename: Tina
authors.initials: T
authors.lastname: Hoshino
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Kelley
authors.forename: Ngoc
authors.initials: N
authors.lastname: Ngo
authors.forename: Thomas
authors.initials: T
authors.lastname: Schisano
authors.forename: Philip
authors.initials: P
authors.lastname: Stevenson
authors.forename: Caroline
authors.initials: C
authors.lastname: Tsou
authors.forename: J P
authors.initials: JP
authors.lastname: Yang
mesh_terms: D001772:Blood Cell Count / Q000295:instrumentation; D048429:Cell Size; D001330:Electronic Data Processing; D004909:Erythrocyte Indices; D006403:Hematologic Tests / Q000295:instrumentation* / Q000592:standards; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D016247:Information Storage and Retrieval; D016014:Linear Models; D015203:Reproducibility of Results
chemical_list: D006454:Hemoglobins