Rabs, Rips, FIPs, and endocytic membrane traffic.
Rab GTPases, proteins belonging to the Ras-like small GTP-binding protein superfamily, have emerged as master regulators of cellular membrane transport. Rab11 GTPase, a member of the Rab protein family, plays a role in regulating various cellular functions, including plasma membrane recycling, phagocytosis, and cytokinesis. Rab11 acts by forming mutually exclusive complexes with Rab11-family binding proteins, known as FIPs. Rab11-FIP complexes serve a role of "targeting complexes" by recruiting various membrane traffic factors to cellular membranes. Recent studies have identified several Rab11-FIP complex-binding proteins that regulate distinct membrane traffic pathways.
Prekeris
Rytis
R
Department of Cellular and Structural Biology, School of Medicine, University of Colorado Health Sciences Center, 4200 E. Ninth Ave., Room 4520, B-111, Denver, CO 80262, USA. Rytis.Prekeris@uchsc.edu
D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D004705:Endocytosis; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D024101:Mitochondrial Proteins; D008969:Molecular Sequence Data; D021381:Protein Transport; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; C485422:RAB11FIP5 protein, human; C463963:RAB11FIP2 protein, human; D020691:rab GTP-Binding Proteins