Left-right asymmetry: nodal cilia make and catch a wave.
Asymmetric fluid flow in the mouse node initiates the development of left-right asymmetry. This flow is generated by motile cilia and is detected by immotile mechanosensory cilia, activating an asymmetric calcium spike.
Yost
H Joseph
HJ
Huntsman Cancer Institute Center for Children, University of Utah, 2000 Circle of Hope, Salt Lake City, Utah 84112, USA. joseph.yost@hci.utah.edu
D000818:Animals; D019521:Body Patterning; D002923:Cilia / Q000502:physiology*; D045604:Extracellular Fluid / Q000502:physiology; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D008954:Models, Biological; D015398:Signal Transduction