title: Association of proinflammatory molecules with apoptotic markers and survival in critically ill multiple organ dysfunction patients.
abstract: Recent evidence supports the involvement of apoptosis in multiple organ dysfunction (MODS). The authors examined the hypothesis that nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-alpha, and cortisol correlate with Fas and Fas ligand (FasL) expression on peripheral blood mononuclear cells and that Fas and FasL, therefore, mediate their association with MODS severity. Thirty-five critically ill adult MODS patients were followed for up to 14 days and were compared to non-MODS matched controls. Fas, FasL, nitrate, cortisol, and IL-6 were elevated in MODS patients (P < 0.05). Nitrate and cortisol correlated with Fas expression (P < 0.05). All factors studied, except for TNF-alpha, correlated with MODS severity (P < 0.05); however, by multivariate analyses, Fas and FasL were independently associated with severity and survival (P < 0.05). The inflammatory molecules studied may mediate the association of apoptotic constituents with MODS severity and survival only in part.
authors.affiliation: University of Athens, School of Nursing, Papadiamantopoulou 123, Athens 11527, Greece. elipapa@nurs.uoa.gr
authors.forename: Elizabeth D E
authors.initials: ED
authors.lastname: Papathanassoglou
authors.forename: Jan A
authors.initials: JA
authors.lastname: Movnihan
authors.forename: Ourania
authors.initials: O
authors.lastname: Dafni
authors.forename: Christos S
authors.initials: CS
authors.lastname: Mantzoros
authors.forename: Michael H
authors.initials: MH
authors.lastname: Ackerman
mesh_terms: D000328:Adult; D000368:Aged; D017209:Apoptosis / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016638:Critical Illness / Q000401:mortality; D003430:Cross-Sectional Studies; D053222:Fas Ligand Protein; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007249:Inflammation; D018836:Inflammation Mediators / Q000097:blood* / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood* / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000737:chemistry; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood* / Q000276:immunology / Q000401:mortality; D015999:Multivariate Analysis; D009569:Nitric Oxide / Q000097:blood* / Q000276:immunology; D012720:Severity of Illness Index; D015996:Survival Rate; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000276:immunology / Q000401:mortality; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000378:metabolism*; D015854:Up-Regulation; D019014:fas Receptor / Q000032:analysis
chemical_list: D015415:Biomarkers; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D018836:Inflammation Mediators; D015850:Interleukin-6; D008562:Membrane Glycoproteins; D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor; D009569:Nitric Oxide; D006854:Hydrocortisone