title: New styryl sulfones as anticancer agents.
abstract: New styryl sulfone compounds have been synthesized and evaluated for their anti-proliferative activity. Among the compounds synthesized, one compound (7k) has shown 51% tumor growth inhibition in mice implanted with HT-29 human carcinoma at 400 mg kg(-1) orally.
authors.affiliation: Discovery Chemistry, Discovery Research, Dr. Reddy's Laboratories, Bollaram Road, 500 050, Hyderabad, India. sarmavm@dreddys.com
authors.forename: Manohar Sharma
authors.initials: MS
authors.lastname: Vedula
authors.forename: Aravind Babu
authors.initials: AB
authors.lastname: Pulipaka
authors.forename: Chandrasekhar
authors.initials: C
authors.lastname: Venna
authors.forename: Vamsee Krishna
authors.initials: VK
authors.lastname: Chintakunta
authors.forename: Sreenu
authors.initials: S
authors.lastname: Jinnapally
authors.forename: Venkata Adiseshu
authors.initials: VA
authors.lastname: Kattuboina
authors.forename: Ravi Krishna
authors.initials: RK
authors.lastname: Vallakati
authors.forename: Vishnu
authors.initials: V
authors.lastname: Basetti
authors.forename: Venkateswarlu
authors.initials: V
authors.lastname: Akella
authors.forename: Sriram
authors.initials: S
authors.lastname: Rajgopal
authors.forename: Ajaya Kumar
authors.initials: AK
authors.lastname: Reka
authors.forename: Sravan Kumar
authors.initials: SK
authors.lastname: Teepireddy
authors.forename: Prem Kumar
authors.initials: PK
authors.lastname: Mamnoor
authors.forename: Ramanujam
authors.initials: R
authors.lastname: Rajagopalan
authors.forename: Gopalakrishnan
authors.initials: G
authors.lastname: Bulusu
authors.forename: Akash
authors.initials: A
authors.lastname: Khandelwal
authors.forename: Vijay V
authors.initials: VV
authors.lastname: Upreti
authors.forename: Srinivas Rao
authors.initials: SR
authors.lastname: Mamidi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D019073:HT29 Cells; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D015394:Molecular Structure; D013450:Sulfones / Q000138:chemical synthesis / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D013450:Sulfones