Antihyperlipidemic effects of different molecular weight sulfated polysaccharides from Ulva pertusa (Chlorophyta).
Ulvan, a sulfated polysaccharide from Ulva pertusa, was degraded to yield two low molecular weight fractions U1 and U2. The molecular weights of ulvan and its fractions were determined and varied from 151.6 to 28.2 kDa. They were fed to rats on a hypercholesterolemic diet for 21 days to evaluate and compare the antihyperlipidemic actions. Ulvan-based diet significantly lowered the levels of serum total cholesterol (-45.2%, P<0.05) and low density lipoprotein cholesterol (LDL-cholesterol, -54.1%, P<0.05). While U1- and U2-based diets significantly elevated the levels of serum high density lipoprotein cholesterol (HDL-cholesterol, +22.0% for U1, not significant; +61.0% for U2; P<0.05) and reduced triglyceride (TG, -82.4% for U1, -77.7% for U2; P<0.05) in rats as compared to control diet. In addition, consumptions of various ulvans significantly increased fecal bile acid excrement. The results indicated that ulvans with different molecular weights exhibited diverse effects on lipid metabolism. The high molecular weight ulvan was effective in serum total and LDL-cholesterol, whereas low molecular weight fractions were in TG and HDL-cholesterol. The fractions were considered to be more beneficial to hyperlipidemia associated with diabetes over ulvan.
Pengzhan
Yu
Y
Department of Chemistry, Institute of Oceanology of the Chinese Academy of Sciences, Qingdao 266071, PR China.
Ning
Li
L
Xiguang
Liu
L
Gefei
Zhou
Z
Quanbin
Zhang
Z
Pengcheng
Li
L
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005243:Feces / Q000737:chemistry; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008970:Molecular Weight; D009539:Nicotinic Acids / Q000494:pharmacology; D011134:Polysaccharides / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017550:Spectroscopy, Fourier Transform Infrared; D013431:Sulfates / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood; D044445:Ulva / Q000737:chemistry*; D014783:Viscosity; D015430:Weight Gain / Q000187:drug effects
D001647:Bile Acids and Salts; D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D008055:Lipids; D009539:Nicotinic Acids; D011134:Polysaccharides; D013431:Sulfates; D014280:Triglycerides; C005193:Inositol Niacinate