title: Bone mineral density of the spine and femur in early postmenopausal Turkish women with endemic skeletal fluorosis.
abstract: The aim of this prospective, comparative study was to investigate the bone mineral density (BMD) changes in a group of early postmenopausal Turkish women with endemic skeletal fluorosis and to study effects of endemic fluorosis on BMD. Bone mineral density of L2-L4 vertebra, femur neck, femur trochanter, and Ward's triangle were measured in 45 female patients with endemic skeletal fluorosis and 41 age-matched controls by dual X-ray absorbtiometry (DXA). The BMD of L2-L4 vertebra and Ward's triangle were higher in the endemic fluorosis group than in the control group (P < 0.001). Patients with endemic fluorosis had higher femur neck and femur trochanter BMDs than did controls (P < 0.01 and P < 0.05, respectively). There was a positive correlation between serum fluoride content and BMD at the spine (r = 0.345, P = 0.001), femoral neck (r = 0.274, P = 0.011), Ward's triangle (r = 0.295, P = 0.006), and trochanter (r = 0.217, P = 0.045). In conclusion, higher bone mineral density levels were seen in early postmenopausal women with endemic skeletal fluorosis. BMD measurement is a tool in the diagnosis and management of this preventable crippling disease.
authors.affiliation: Department of Nuclear Medicine, Süleyman Demirel University, School of Medicine, Isparta, Turkey. mustiyildiz01@ixir.com
authors.forename: M
authors.initials: M
authors.lastname: Yildiz
authors.forename: M
authors.initials: M
authors.lastname: Akdoğan
authors.forename: N
authors.initials: N
authors.lastname: Tamer
authors.forename: B
authors.initials: B
authors.lastname: Oral
mesh_terms: D015502:Absorptiometry, Photon; D015519:Bone Density; D001847:Bone Diseases / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D019353:Endemic Diseases; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000378:metabolism*; D005458:Fluoride Poisoning / Q000097:blood* / Q000150:complications / Q000473:pathology; D005459:Fluorides / Q000097:blood; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000378:metabolism*; D008875:Middle Aged; D017698:Postmenopause / Q000502:physiology*; D011446:Prospective Studies; D014421:Turkey; D014881:Water Supply
chemical_list: D005459:Fluorides