Comparison study of oxygen-induced MRI-signal changes and pO2 changes in murine tumors.
The purpose of this study was to compare the results from oxygen-induced MR-signal intensity changes with polarographic pO2 measurements in tumors. Balb-c mice with an intramuscular transplanted osteosarcoma were examined. To study the response of tumors to changes in oxygen supply, hyperoxia was induced by breathing pure oxygen for a short period. The examination of each animal started with T2* weighted MRI followed by the pO2 measurements (Eppendorf Histograph). During oxygen inhalation in all tumors, when the hypoxic tumor fraction drops, both areas of significant MR-signal intensity increase and decrease were observed in each animal.
Weissfloch
Lothar
L
Dept. of Radiation Oncology, Klinikum rechts der Isar, TU Munich, Germany.
Peller
Michael
M
Weber
Juergen
J
Feldmann
Hans-Juergen
HJ
Senekowitsch-Schmidtke
Reingart
R
Tempel
Karlheinz
K
Coderre
Jeffrey A
JA
Molls
Michael
M
Reiser
Michael
M
D000818:Animals; D008279:Magnetic Resonance Imaging; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism*; D012516:Osteosarcoma / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*
D010100:Oxygen