Synthesis and biological evaluation of pyrimidine nucleosides fused with 3',4'-tetrahydrofuran ring.
Pyrimidine nucleosides fused with 3',4'-tetrahydrofuran ring were synthesized, starting from 1,2;5,6-di-O-isopropylidene-D-glucose and assayed for antiviral activities. Thymine analogue 1 and its corresponding 2'-deoxy analogue 3 exhibited high cytotoxicity instead of giving antiviral activities.
Chun
Moon Woo
MW
College of Pharmacy, Seoul National University, Seoul, Korea. mwchun@snu.ac.kr
Kim
Myong Jung
MJ
Kim
Hea Ok
HO
Moon
Hyung Ryong
HR
Kim
Hee-Doo
HD
Kim
Joong Hyup
JH
Jeong
Lak Shin
LS
D005663:Furans; D007202:Indicators and Reagents; D008958:Models, Molecular; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
D005663:Furans; D007202:Indicators and Reagents; D011741:Pyrimidine Nucleosides; C018674:tetrahydrofuran