2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaB.
The aim of this study was to evaluate, using a rat model of balloon angioplasty, whether prostaglandin (PG) J(2) and 2-cyclopenten-1-one are able to reduce restenosis. We found that both PGJ(2) and 2-cyclopenten-1-one, administered by local application on carotid arteries, caused a dose-dependent inhibition of neointimal formation. Furthermore, both agents prevented vascular negative remodeling. The effect of these compounds on restenosis was correlated with an inhibition of nuclear factor-kappaB (NF-kappaB) activation as well as of intercellular adhesion molecule-1 (ICAM-1) protein expression in injured carotid arteries of control animals. Our results show that cyclopentenone PGs and their derivatives reduce restenosis and may have therapeutic relevance for the prevention of human restenosis.
Ianaro
Angela
A
Department of Experimental Pharmacology, University of Naples Federico II, Italy.
Maffia
Pasquale
P
Cuzzocrea
Salvatore
S
Mazzon
Elena
E
Santoro
Maria Gabriella
MG
Di Rosa
Massimo
M
Ialenti
Armando
A
D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D023903:Coronary Restenosis / Q000188:drug therapy* / Q000378:metabolism*; D003517:Cyclopentanes / Q000494:pharmacology / Q000627:therapeutic use*; D024202:Electrophoretic Mobility Shift Assay; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D008297:Male; D016328:NF-kappa B / Q000378:metabolism*; D015230:Prostaglandin D2 / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D017539:Tunica Intima / Q000187:drug effects / Q000473:pathology
D003517:Cyclopentanes; D016328:NF-kappa B; D018799:Intercellular Adhesion Molecule-1; C037112:9-deoxy-delta-9-prostaglandin D2; C013905:cyclopentenone; D015230:Prostaglandin D2