[Herpes simplex keratitis after ophthalmic surgery].
OBJECTIVE
We report 6 cases of herpes simplex keratitis after ophthalmic surgery, in eyes without clinical history of herpes simplex keratitis.


METHODS
These cases comprised 6 patients examined at our hospital between April 1992 and November 2001. Past operations were keratoplasty in 5 eyes and cataract surgery in 1 eye. Clinical findings and predisposing factors were evaluated retrospectively. The period between herpetic epithelial keratitis onset and ophthalmic surgery ranged from 1.5 to 79 months. Predisposing factors included corticosteroid therapy and operative wound. The herpetic epithelial lesions were dendritic ulcers in 2 eyes, geographic ulcer in 1 eye, and atypical epithelial lesions in 3 eyes; in all cases, herpes simplex virus (HSV)-DNA was detected by polymerase chain reaction (PCR) in tear fluid. All herpetic epithelial lesions healed with oral and topical acyclovir.


CONCLUSIONS
When corticosteroids are used following ophthalmic surgery, physicians should be alert to the possibility of herpetic epithelial keratitis, even in patients with no clinical history of herpes simplex keratitis. PCR detection in tear fluid is helpful in diagnosing this disease.
Miyajima
Seiya
S
Department of Ophthalmology, Kyoto Prefectural University of Medicine, 456 Kajii-cho, Kawaramachi, Kamigyo-ku, Kyoto 602-0841, Japan.
Sano
Yoichiro
Y
Sotozono
Chie
C
Yokoi
Norihiko
N
Ishino
Yutaka
Y
Kinoshita
Shigeru
S
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016849:Keratitis, Herpetic / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D011183:Postoperative Complications; D012189:Retrospective Studies; D013530:Surgical Wound Infection