[Mechanism of quercetin as an antidiarrheal agent].
OBJECTIVE
To investigate the antidiarrheal mechanism of quercetin extracted from Psidium guajava L.


METHODS
The effects of quercetin on the contractility of guinea pig ileum in vitro and on the peristaltic motion of mouse small intestine in vivo were observed, and the peak value of contractility and peristaltic distance recorded. The inhibitory effect of quercetin on the permeability of the abdominal capillaries was also observed.


RESULTS
Quercetin inhibited the contraction of guinea pig ileum in vitro and the peristaltic motion of mouse small intestine, and reduced the permeability of abdominal capillaries.


CONCLUSIONS
Quercetin can inhibit the intestinal movement and reduce capillary permeability in the abdominal cavity, which may be the antidiarrheal mechanism of Psidium guajava L extract.
Zhang
Wen-ju
WJ
Department of Traditional Chinese Medicine, First Military Medical University, Guangzhou 510515, China. zhangwj91@sohu.com
Chen
Bao-tian
BT
Wang
Cai-yun
CY
Zhu
Quan-hong
QH
Mo
Zhi-xian
ZX
D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D011794:Quercetin / Q000494:pharmacology*
D000930:Antidiarrheals; D001285:Atropine; D011794:Quercetin