Synthesis of oligonucleotide prodrugs bearing N-acetyl nucleobases.
N-Acetyl oligonucleotides and their prodrugs were synthesized on photolabile solid support. Tm studies showed a decrease of hydridization for N-acetyl A and G and an increase for N-acetyl C. In cells extract, acetyl groups were hydrolysed.
Brès
J C
JC
Laboratoire de Chimie Organique Biomoléculaire de Synthèse, Université de Montpellier II, UMR 5625 CNRS-UMII, Montpellier Cedex, France.
Imbach
J L
JL
Morvan
F
F
D000107:Acetylation; D001483:Base Sequence; D006868:Hydrolysis; D007202:Indicators and Reagents; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D007202:Indicators and Reagents; D009705:Nucleosides; D009841:Oligonucleotides; D011355:Prodrugs