title: Comprehensive step-by-step engineering of an (R)-hydroxynitrile lyase for large-scale asymmetric synthesis.
authors.affiliation: Institut für Biotechnologie, Technische Universität Graz, Petersgasse 12, 8010 Graz, Austria. glieder@glieder.com
authors.forename: Anton
authors.initials: A
authors.lastname: Glieder
authors.forename: Roland
authors.initials: R
authors.lastname: Weis
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Skranc
authors.forename: Peter
authors.initials: P
authors.lastname: Poechlauer
authors.forename: Ingrid
authors.initials: I
authors.lastname: Dreveny
authors.forename: Sandra
authors.initials: S
authors.lastname: Majer
authors.forename: Marcel
authors.initials: M
authors.lastname: Wubbolts
authors.forename: Helmut
authors.initials: H
authors.lastname: Schwab
authors.forename: Karl
authors.initials: K
authors.lastname: Gruber
mesh_terms: D000097:Acetonitriles / Q000737:chemistry; D002713:Chlorine / Q000737:chemistry; D006031:Glycosylation; D006836:Hydro-Lyases / Q000138:chemical synthesis*; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D009570:Nitriles / Q000138:chemical synthesis; D010843:Pichia; D012441:Saccharomyces cerevisiae
chemical_list: D000097:Acetonitriles; D009570:Nitriles; C430593:cyanohydrin; D002713:Chlorine; C045516:mandelonitrile; D006836:Hydro-Lyases; C048831:nitrile hydratase