AP-2 makes room for rivals.
Clathrin and the adaptor protein complex (AP-2) constitute the major coat components of clathrin-coated vesicles. In the September issues of the Journal of Cell Biology and the Journal of Biological Chemistry, three reports reveal that AP-2, while essential for internalization of transferrin, is not essential for internalization of EGF. These novel data suggest the intriguing possibility that the major role of AP-2 is in cargo recruitment, and not in assembly of functionally active clathrin-coated pits.
Sever
Sanja
S
Department of Medicine, Harvard Medical School and Program in Membrane Biology, Renal Unit, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.
D033962:Adaptor Protein Complex 2 / Q000235:genetics / Q000502:physiology*; D000818:Animals; D002966:Clathrin / Q000502:physiology; D018699:Coated Vesicles / Q000502:physiology; D004705:Endocytosis / Q000502:physiology; D034741:RNA, Small Interfering
D033962:Adaptor Protein Complex 2; D002966:Clathrin; D034741:RNA, Small Interfering