Synthesis and antiviral activity assay of novel (E)-3',5'-diamino-5-(2-bromovinyl)-2',3',5'-trideoxyuridine.
(E)-3',5'-diamino-5-(2-bromovinyl)-2',3',5'-trideoxyuridine (5), the diamino analogue of BVDU (1), was synthesized from BVDU. In contrast with BVDU, compound 5 did not show activity against herpes simplex virus or varicella-zoster virus.
Lavandera
Iván
I
Departamento de Química Orgánica e Inorgánica, Facultad de Química, Universidad de Oviedo, Oviedo, Spain.
Fernández
Susana
S
Ferrero
Miguel
M
De Clercq
Erik
E
Gotor
Vicente
V
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives* / Q000737:chemistry; D015195:Drug Design; D007202:Indicators and Reagents; D015394:Molecular Structure; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014753:Vinyl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000998:Antiviral Agents; D007202:Indicators and Reagents; D014753:Vinyl Compounds; C052700:3',5'-di-O-acetyl-5-(2-bromovinyl)-2'-deoxyuridine; D001973:Bromodeoxyuridine; D014529:Uridine