title: Synthesis and triplex binding properties of oligonucleotides containing a novel nucleobase.
abstract: The thiazolo-indole compound 1 bearing the complementary donor-acceptor-donor sites (dad) was designed for specific recognition of an AT inverted base pair in pyrimidine triple helix motif. It was successfully incorporated into 14-mer oligonucleotide using a serinol unit as sugar derivative. The triple helix hybridization studies were examined by means of thermal denaturation experiments with a 26-mer DNA duplex containing the AT inverted base pair.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS, 91198, Gif sur Yvette, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Lecubin
authors.forename: Michel
authors.initials: M
authors.lastname: Devys
authors.forename: Jean Louis
authors.initials: JL
authors.lastname: Fourrey
authors.forename: Jian-Sheng
authors.initials: JS
authors.lastname: Sun
authors.forename: Rachid
authors.initials: R
authors.lastname: Benhida
mesh_terms: D000225:Adenine; D020029:Base Pairing; D001483:Base Sequence; D001665:Binding Sites; D003855:Deoxyribose / Q000031:analogs & derivatives*; D006860:Hydrogen Bonding; D009693:Nucleic Acid Hybridization; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D013941:Thymine
chemical_list: D009838:Oligodeoxyribonucleotides; D003855:Deoxyribose; D000225:Adenine; D013941:Thymine