title: Fatty acid metabolism in neonatal chickens (Gallus domesticus) treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3,3',4,4',5-pentachlorobiphenyl (PCB-126) in ovo.
abstract: Treatment of chickens as pre-incubation embryos with TCDD or PCB-126 altered fatty acid concentrations in their plasma 21 days later, compared with their oil vehicles (sunflower and corn oils, respectively). TCDD increased the concentrations of total fatty acids, lipid classes (phospholipids and cholesterol ester), fatty acid families (saturated, n-7 and n-6), and many specific fatty acids. The only fatty acid concentrations decreased by TCDD treatment were those of cholesterol ester fatty acids 20:3n3 and 24:6n3 and overall plasma 24:6n3. In contrast, PCB-126 treatment decreased total phospholipid, saturated and plasmogen fatty acid concentrations with generally decreasing trends in specific fatty acid concentrations. However, both TCDD and PCB-126 treatments increased total 22:1n9 and decreased 24:6n3 concentrations compared with their respective vehicles. The potential relationship between those fatty acid concentrations altered by toxicant treatment and alterations in brain symmetry was then examined using correlation analysis. Several fatty acid concentrations were significantly correlated with differences in brain morphology between the right and left hemispheres and these potential associations were different between toxicant and vehicle.
authors.affiliation: Center for Health and the Environment, University of California, Davis, CA 95616, USA. Beckye_Stanton@fws.gov
authors.forename: Beckye
authors.initials: B
authors.lastname: Stanton
authors.forename: Jamie
authors.initials: J
authors.lastname: DeWitt
authors.forename: Diane
authors.initials: D
authors.lastname: Henshel
authors.forename: Steven
authors.initials: S
authors.lastname: Watkins
authors.forename: Bill
authors.initials: B
authors.lastname: Lasley
mesh_terms: D000014:Abnormalities, Drug-Induced; D000818:Animals; D001921:Brain / Q000002:abnormalities / Q000187:drug effects; D002642:Chick Embryo; D002645:Chickens / Q000378:metabolism*; D005314:Embryonic and Fetal Development / Q000187:drug effects / Q000502:physiology; D004965:Estrogen Antagonists / Q000633:toxicity*; D005227:Fatty Acids / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D013723:Teratogens / Q000633:toxicity*
chemical_list: D004965:Estrogen Antagonists; D005227:Fatty Acids; D000072317:Polychlorinated Dibenzodioxins; D013723:Teratogens; D011078:Polychlorinated Biphenyls; C023035:3,4,5,3',4'-pentachlorobiphenyl