title: [Effect of latanoprost on diurnal variations of intraocular pressure in normal-tension glaucoma].
abstract: OBJECTIVE
  To study the effect of instillation of latanoprost on the diurnal variation in the intraocular pressure(IOP), blood pressure, and pulse rate in patients with normal-tension glaucoma(NTG).
  
  
  METHODS
  The diurnal variation in the IOP was determined in 23 eyes in 23 NTG patients after a washout period of 4 weeks or longer. The diurnal variation in IOP was then remeasured after latanoprost monotherapy of 8 weeks or longer. The IOP was measured by the Goldmann applanation tonometer at 10:00, 13:00, 16:00, 19:00, 22:00, 01:00, 03:00, 07:00, and 10:00 before and after treatment, and the IOP at each time point, mean diurnal IOP, maximum IOP, minimum IOP, and range of variation in IOP were compared before and after treatment. The blood pressure and pulse rate before and after treatment were also measured and compared.
  
  
  RESULTS
  The IOP decreased significantly at all time points. The treatment caused significant decreases in the mean diurnal IOP, maximum IOP, minimum IOP, and range of variation in IOP. There were no differences in the blood pressure and pulse rate before and after treatment.
  
  
  CONCLUSIONS
  Latanoprost significantly decreases the IOP throughout the day in NTG patients, and has no effects on the blood pressure and pulse rate. It is therefore useful in the treatment of NTG.
authors.affiliation: Department of Ophthalmology, Tokyo Metropolitan Police Hospital, 2-10-41 Fujimi, Chiyoda-ku, Tokyo 102-0071, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakamoto
authors.forename: Noriko
authors.initials: N
authors.lastname: Yasuda
authors.forename: Mami
authors.initials: M
authors.lastname: Nanno
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Kinohira
authors.forename: Keiko
authors.initials: K
authors.lastname: Murai
authors.forename: Takumi
authors.initials: T
authors.lastname: Fukuda
mesh_terms: D002940:Circadian Rhythm / Q000187:drug effects*; D005260:Female; D005901:Glaucoma / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use*
chemical_list: D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost