title: Chemokines and cytokines: axis and allies in asthma and allergy.
abstract: Allergic asthma can be precipitated by many factors. For the atopic person, fungus, pollen, dust mites, cockroach antigens, and diesel exhaust are all agents that may trigger an allergic attack. Cytokines and chemokines are integral mediators of fungal asthma. From the earliest time points, they recruit and activate the cells required for the clearance of fungus as well as being critical factors involved in the immunopathology of this disease. In the final analysis, it is clear that these mediators can act to the benefit or the detriment of the host.
authors.affiliation: Department of Pathology, University of Michigan Medical School, Medical Science I, Room 5214, 1301 Catherine Road, Ann Arbor, MI 48109-0602, USA. janeschu@umich.edu
authors.forename: Jane M
authors.initials: JM
authors.lastname: Schuh
authors.forename: Kate
authors.initials: K
authors.lastname: Blease
authors.forename: Steven L
authors.initials: SL
authors.lastname: Kunkel
authors.forename: Cory M
authors.initials: CM
authors.lastname: Hogaboam
mesh_terms: D000818:Animals; D001232:Aspergillus fumigatus / Q000378:metabolism; D001249:Asthma / Q000378:metabolism* / Q000382:microbiology; D018925:Chemokines / Q000502:physiology*; D016207:Cytokines / Q000378:metabolism / Q000502:physiology*; D005656:Fungal Proteins / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism* / Q000382:microbiology; D008168:Lung / Q000276:immunology; D008954:Models, Biological; D010587:Phagocytosis; D018418:Th2 Cells / Q000378:metabolism
chemical_list: D018925:Chemokines; D016207:Cytokines; D005656:Fungal Proteins