title: Macrophage-derived IL-18 targeting for the treatment of Crohn's disease.
abstract: Crohn's disease is an inflammatory bowel disease associated with several changes in the immune system, including an increased number of infiltrating macrophages. These macrophages release a variety of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha, macrophage infiltrating factor (MIF), interleukin (IL)-6, IL-12 and IL-18, which are critically involved in the onset and the development of Crohn's disease. We here focus on the role of macrophages, especially macrophage-derived IL-18 in both patients with Crohn's disease and a murine model of Crohn's disease.
authors.affiliation: Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. taka.gast@tmd.ac.jp
authors.forename: Takanori
authors.initials: T
authors.lastname: Kanai
authors.forename: Koji
authors.initials: K
authors.lastname: Uraushihara
authors.forename: Teruji
authors.initials: T
authors.lastname: Totsuka
authors.forename: Akira
authors.initials: A
authors.lastname: Okazawa
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Hibi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Oshima
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Miyata
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Nakamura
authors.forename: Mamoru
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D003424:Crohn Disease / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D006801:Humans; D000922:Immunotoxins / Q000494:pharmacology; D020382:Interleukin-18 / Q000502:physiology*; D008264:Macrophages / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000187:drug effects / Q000502:physiology; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology; D051193:Toll-Like Receptors
chemical_list: D000911:Antibodies, Monoclonal; D000922:Immunotoxins; D020382:Interleukin-18; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors