title: Characterization of experimental equine glanders.
abstract: Considerable advances in understanding of the disease caused by Burkholderia mallei have been made employing a combination of tools including genetic techniques and animal infection models. The development of small animal models has allowed us to assess the role of a number of putative virulence determinants in the pathogenesis of disease due to B. mallei. Due to the difficulties in performing active immunization studies in small animals, and due to the fact that the horse is the target mammalian species for glanders, we have initiated experimental studies on glanders in horses. Intratracheal deposition of B. mallei produced clinical glanders with organisms being recovered from tissues of infected horses. The model should prove to be of considerable value in our ongoing studies on the pathogenesis and vaccine development for glanders.
authors.affiliation: National Centre for Foreign Animal Disease, 1015 Arlington St., Suite T2300, Winnipeg, Man., Canada R3E 3M4.
authors.forename: Jose
authors.initials: J
authors.lastname: Lopez
authors.forename: John
authors.initials: J
authors.lastname: Copps
authors.forename: Catherine
authors.initials: C
authors.lastname: Wilhelmsen
authors.forename: Richard
authors.initials: R
authors.lastname: Moore
authors.forename: Julie
authors.initials: J
authors.lastname: Kubay
authors.forename: Marcel
authors.initials: M
authors.lastname: St-Jacques
authors.forename: Stacey
authors.initials: S
authors.lastname: Halayko
authors.forename: Christiaan
authors.initials: C
authors.lastname: Kranendonk
authors.forename: Shannon
authors.initials: S
authors.lastname: Toback
authors.forename: David
authors.initials: D
authors.lastname: DeShazer
authors.forename: David L
authors.initials: DL
authors.lastname: Fritz
authors.forename: Marina
authors.initials: M
authors.lastname: Tom
authors.forename: Donald E
authors.initials: DE
authors.lastname: Woods
mesh_terms: D000818:Animals; D019117:Burkholderia / Q000302:isolation & purification*; D018562:Disease Transmission, Infectious / Q000662:veterinary; D005896:Glanders / Q000453:epidemiology / Q000382:microbiology*; D006734:Horse Diseases / Q000382:microbiology*; D006736:Horses