title: Olefinic peptide nucleic acid (OPA).
abstract: The olefinic peptide nucleic acid analogues (OPA) monomers containing the bases thymine and adenine were synthesised in 11 steps. Fully modified oligomers containing these units were prepared and their pairing properties assessed by means of UV-melting experiments.
authors.affiliation: Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Gautschi
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Leumann
mesh_terms: D000225:Adenine; D000475:Alkenes; D020029:Base Pairing; D001483:Base Sequence; D013058:Mass Spectrometry; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D013941:Thymine
chemical_list: D000475:Alkenes; D009838:Oligodeoxyribonucleotides; D020135:Peptide Nucleic Acids; D000225:Adenine; D013941:Thymine