[Risk factors for amoxicillin-clavulanate-resistant Escherichia coli in ICU patients].
OBJECTIVE
To determine risk factors of infections with amoxicillin-clavulanate-resistant Escherichia coli in ICU patients.


METHODS
Prospective, consecutive sample survey study.


METHODS
A consecutive series of 133 patients from whom culture results were positive for E. coli during their ICU stay.


METHODS
Risk factors analysed included demographics, comorbid conditions, and antimicrobial drug exposure. Univariate and multivariate analysis were performed.


RESULTS
Multivariate logistic regression analysis identified only one significant independent factor associated with the emergence of amoxicillin-clavulanate-resistant E. coli: prior use of amoxicillin (odds ratio: 5.45).


CONCLUSIONS
Clinicians should avoid administering amoxicillin-clavulanate as empiric therapy for possible E. coli infection in patients that have recently been treated with amoxicillin.
Mohammedi
I
I
Service de réanimation chirurgicale, hôpital Edouard-Herriot, université Claude-Bernard, Lyon, France. ismael.mohammedi@chu-lyon.fr
Denis
A
A
Duperret
S
S
Chapuis
F
F
Ploin
D
D
Petit
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000627:therapeutic use; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use*; D000704:Analysis of Variance; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D024881:Drug Resistance, Bacterial; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D004927:Escherichia coli Infections / Q000150:complications / Q000453:epidemiology* / Q000382:microbiology*; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010406:Penicillins / Q000627:therapeutic use; D012307:Risk Factors
D010406:Penicillins; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin