Practical synthesis of D-cyclopent-2-enone, the key intermediate of carbocyclic nucleosides.
An efficient and practical method for the synthesis of (4R,5R)-4,5-O-isopropylidene-cyclopent-2-enone was developed from D-ribose by using a ring-closing metathesis reaction.
Jin
Y H
YH
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, Georgia 30602-2352, USA.
Chu
C K
CK
D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D008958:Models, Molecular; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
C479169:(4R,5R)-4,5-O-isopropylidene-cyclopent-2-enone; D003517:Cyclopentanes; D007202:Indicators and Reagents; D009705:Nucleosides