title: COMET: a proposed mechanism of action to explain the results and concerns about dose.
authors.forename: J
authors.initials: J
authors.lastname: Wikstrand
authors.forename: B
authors.initials: B
authors.lastname: Fagerberg
authors.forename: S
authors.initials: S
authors.lastname: Goldstein
authors.forename: J
authors.initials: J
authors.lastname: Kjekshus
authors.forename: H
authors.initials: H
authors.lastname: Wedel
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008790:Metoprolol / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D008790:Metoprolol