[Level of interferon-gamma, tumor necrosis factor alpha, and antibodies to them in blood serum from Parkinson disease patients].
Serum levels of interferon-gamma (IF gamma), tumor necrosis factor alpha (TNF alpha) and autoantibodies (a-AT) to these cytokines were investigated in patients with Parkinson's disease (PD). The increased levels of TNF alpha (50%) and IF gamma (35%) were found in PD patients. There was close correlation between the serum level of TNF alpha and the manifestation of neurological symptoms (r = 0.434; p < 0.05), and between levels of IF gamma and the duration of this disease (r = 0.4511, p < 0.05) and patients age as well (r = 0.4358; p < 0.05). There was increased level of a-AT to TNF alpha in PD patients versus healthy controls (130.3 +/- 11.92 and 105.3 +/- 4.62, respectively, p < 0.05). The combined increase of levels of a-AT to TNF alpha and IF gamma (r = 0.91, p < 0.01) close reverse correlation between duration of PD and levels of a-AT to TNF alpha and IF gamma (r = 0.4644 and r = 0.606, respectively, p < 0.01) were also recognised. The data obtained suggest the involvement of TNF alpha and IF gamma into the pathological process during PD, which requires further investigation in this direction.
Gribova
I E
IE
29 Municipal Hospital of Moscow Public Health Department, Gospitalnaya Square, 2, 111020, Moscow.
Gnedenko
B B
BB
Poleshchuk
V V
VV
Morozov
S G
SG
D001324:Autoantigens / Q000097:blood*; D016022:Case-Control Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007371:Interferon-gamma / Q000097:blood* / Q000276:immunology; D010300:Parkinson Disease / Q000097:blood* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000378:metabolism*
D001324:Autoantigens; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma