DNA repair by bacterial AlkB proteins.
The Escherichia coli AlkB protein is an iron- and 2-oxoglutarate-dependent oxygenase, repairing 1-methyladenine and 3-methylcytosine lesions in DNA. AlkB homologues are present in a number of bacterial species, and some bacteria have two different AlkB proteins. AlkB also repairs lesions in RNA, and the biological significance of RNA repair is discussed.
Falnes
Pål Ø
PØ
Centre for Molecular Biology and Neuroscience and Institute of Medical Microbiology, University of Oslo, Rikshospitalet, 0027 Oslo, Norway. pal.falnes@labmed.uio.no
Rognes
Torbjørn
T
D000225:Adenine / Q000031:analogs & derivatives* / Q000378:metabolism; D000478:Alkylation; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D003596:Cytosine / Q000031:analogs & derivatives* / Q000378:metabolism; D004260:DNA Repair; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D010105:Oxygenases / Q000235:genetics / Q000378:metabolism*; D010802:Phylogeny; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; C036386:3-methylcytosine; C008407:1-methyladenine; D003596:Cytosine; D006899:Mixed Function Oxygenases; D010105:Oxygenases; C433124:iron(II) oxygenase; C466427:AlkB protein, E coli; D000225:Adenine