title: Synthesis and DNA binding properties of DNA-PNA chimeras.
abstract: A systematic study to evaluate the ability of 5'-DNA-3'-p-(N)-PNA-(C) chimeras to form triple helix structures has been undertaken. Preliminary results carried out on a 16-mer chimera with three PNA monomers at the 3'-end showed the formation of a stable DNA-PNA/DNA/DNA triplex, having similar conformational behaviour to a canonical DNA/DNA/DNA triplex.
authors.affiliation: Dipartimento di Chimica, Università degli Studi di Napoli Federico II, Napoli, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Barone
authors.forename: L
authors.initials: L
authors.lastname: De Napoli
authors.forename: G
authors.initials: G
authors.lastname: Di Fabio
authors.forename: E
authors.initials: E
authors.lastname: Erra
authors.forename: C
authors.initials: C
authors.lastname: Giancola
authors.forename: A
authors.initials: A
authors.lastname: Messere
authors.forename: D
authors.initials: D
authors.lastname: Montesarchio
authors.forename: L
authors.initials: L
authors.lastname: Petraccone
authors.forename: G
authors.initials: G
authors.lastname: Piccialli
mesh_terms: D001665:Binding Sites; D002678:Chimera; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000737:chemistry*
chemical_list: D009838:Oligodeoxyribonucleotides; D020135:Peptide Nucleic Acids; D004247:DNA