title: Corneal thickness measurements and frequency doubling technology perimetry abnormalities in ocular hypertensive eyes.
abstract: OBJECTIVE
  It has been suggested that some patients currently diagnosed with ocular hypertension (OHT) may have thicker than average corneas that result in an overestimation of their true intraocular pressure. Consequently, patients with OHT with greater corneal thickness may be at a lower risk for functional glaucomatous damage, including visual field loss measured with frequency doubling technology (FDT) perimetry. The purpose of this study was to evaluate the frequency of FDT perimetry deficits in patients with OHT and to correlate these findings with central corneal thickness (CCT) measurements.
  
  
  METHODS
  Observational case control study.
  
  
  METHODS
  Sixty-five patients with OHT with normal optic discs and normal standard achromatic automated perimetry (SAP) visual fields and 52 normal control subjects.
  
  
  METHODS
  All participants underwent SAP, FDT perimetry, and CCT measurements using ultrasound pachymetry.
  
  
  METHODS
  CCT measurements in patients with OHT with abnormal repeatable FDT test results were compared with CCT measurements in patients with OHT with normal FDT results. In addition, CCT measurements in patients with OHT were compared with CCT measurements in normal control subjects.
  
  
  RESULTS
  Fourteen of 65 patients with OHT (21.5%) demonstrated repeatable FDT abnormalities. The mean CCT of patients with OHT with abnormal FDT results was significantly lower than the mean CCT of patients with OHT with normal FDT results (542+/-35 microm versus 575+/-35 microm; P = 0.003). The mean CCT in the normal control group was 556+/-36 microm. The mean CCT in patients with OHT with normal FDT results was significantly higher than in normal subjects (P = 0.008). No statistically significant difference was found between mean CCT in normal subjects and in patients with OHT with abnormal FDT results (P = 0.18).
  
  
  CONCLUSIONS
  Patients currently diagnosed with OHT, but with visual field loss detected by FDT perimetry, had significantly lower CCT measurements than patients with OHT with normal FDT results. These findings suggest that patients with OHT with thinner corneas are more likely to develop early glaucomatous functional damage and that CCT measurements should be taken into account when assessing risk for the development of glaucoma among OHT subjects.
authors.affiliation: Hamilton Glaucoma Center and Visual Function Laboratory, Department of Ophthalmology, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0946, USA.
authors.forename: Felipe A
authors.initials: FA
authors.lastname: Medeiros
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Sample
authors.forename: Robert N
authors.initials: RN
authors.lastname: Weinreb
mesh_terms: D016022:Case-Control Studies; D003315:Cornea / Q000473:pathology*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis*; D012307:Risk Factors; D014786:Vision Disorders / Q000175:diagnosis*; D058609:Visual Field Tests / Q000379:methods; D014794:Visual Fields