Influence of felbamate on the antinociceptive action of morphine, metamizol and indomethacin in mice.
The influence of felbamate (200 mg/kg or 50 mg/kg) on antinociceptive effect of morphine (10 mg/kg), metamizol (500 mg/kg) and indomethacin (10 mg/kg or 1.4 mg/kg) was investigated in a mouse model using the hot-plate test. All drugs were injected intraperitoneally. Felbamate was administered to mice 30 min before applying the analgesic drugs. Measurement of nociception was performed within 2 h after felbamate administration. The research studies were further conducted with a multiple (10 days) drug dosage. Felbamate in the dose of 200 mg/kg significantly increases the analgesic effect of morphine and weakens the effect of metamizol and indomethacin. Multiple administration of felbamate does not affect the activity of morphine and metamizol, but decreases analgesic effect of indomethacin.
Pakulska
Wanda
W
Department of Pharmacodynamics, Medical University of Łódź, 1 Muszyńskiego Str., 90-151 Łódź, Poland. wpakulska@pharm.am.lodz.pl
Wejman
Irena
I
Czarnecka
Elzbieta
E
D000700:Analgesics / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D004177:Dipyrone / Q000494:pharmacology*; D004357:Drug Synergism; D000078328:Felbamate; D007213:Indomethacin / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects; D048448:Phenylcarbamates; D011409:Propylene Glycols / Q000008:administration & dosage / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects
D000700:Analgesics; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D018696:Neuroprotective Agents; D048448:Phenylcarbamates; D011409:Propylene Glycols; D004177:Dipyrone; D009020:Morphine; D000078328:Felbamate; D007213:Indomethacin