SATE (aryl) phosphotriester series. II. Stability studies and physicochemical parameters.
The stability of phosphotriester derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) bearing a S-pivaloyl-2-thioethyl (tBuSATE) group and various aryl residues derived from L-tyrosine was evaluated in biological media. The results demonstrate that such compounds give rise to intracellular delivery of the parent mononucleotide through esterase and phosphodiesterase hydrolytic steps, successively.
Coussot
G
G
Université Montpellier II, UMR 5625 CNRS, Montpellier, France.
Lefebvre
I
I
Dimalta
D
D
Peyrottes
S
S
Pompon
A
A
Gosselin
G
G
Périgaud
C
C
D002460:Cell Line; D054306:Dideoxynucleotides; D004355:Drug Stability; D006678:HIV / Q000187:drug effects*; D006801:Humans; D007202:Indicators and Reagents; D013937:Thymidine Kinase / Q000172:deficiency; D013942:Thymine Nucleotides / Q000493:pharmacokinetics; D014443:Tyrosine / Q000031:analogs & derivatives; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000493:pharmacokinetics
D054306:Dideoxynucleotides; D007202:Indicators and Reagents; D013942:Thymine Nucleotides; C057287:3'-azido-3'-deoxythymidine 5'phosphate; D014443:Tyrosine; D015215:Zidovudine; D013937:Thymidine Kinase