Structural and functional genomics and evolutionary relationships in the cluster of genes encoding murine 2',5'-oligoadenylate synthetases.
2',5'-Oligoadenylate synthetases (2',5'-OASs) are interferon-inducible enzymes. Some of these proteins play an important role in cellular physiology, in particular, in the innate defense mechanisms against RNA virus infections. In the present publication we report the complete genomic structure of the cluster of genes encoding mouse 2',5'-OAS, with all its transcription units, their predicted functions, and their evolutionary relationships. We found that mouse Oas2/Oas3 genes have a genomic structure similar to that of human OAS2/OAS3, while the mouse equivalent of human OAS1 is composed of eight (Oas1a to Oas1h) tandemly arranged transcription units. For all these eight genes a specific inducible promoter controls transcription. The possible functions of this family of proteins are discussed.
Mashimo
Tomoji
T
Unité de Génétique des Mammifères, Institut Pasteur, 75724 Paris Cedex 15, France.
Glaser
Philippe
P
Lucas
Marianne
M
Simon-Chazottes
Dominique
D
Ceccaldi
Pierre Emmanuel
PE
Montagutelli
Xavier
X
Desprès
Philippe
P
Guénet
Jean Louis
JL
D015088:2',5'-Oligoadenylate Synthetase / Q000737:chemistry* / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D019143:Evolution, Molecular; D015870:Gene Expression; D008040:Genetic Linkage; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D005810:Multigene Family; D010802:Phylogeny; D020161:Physical Chromosome Mapping; D020033:Protein Isoforms; D016415:Sequence Alignment; D014158:Transcription, Genetic
D020033:Protein Isoforms; D015088:2',5'-Oligoadenylate Synthetase