Grb10 adapter protein as regulator of insulin-like growth factor receptor signaling.
Grb10 is a member of a superfamily of adapter proteins that includes Grb10, 7, 14, and a protein of Caenorhabditis elegans called Mig10. Grb10 proteins are binding partners for several trans-membrane tyrosine-kinase receptors, including the insulin-like growth factor receptor (IGF-IR) and the insulin receptor (IR). Many recent reports have suggested a very important role of Grb10 in regulating IGF-IR signaling. In this review, we will focus on the role of Grb10 in IGF-I-induced mitogenesis and we will discuss the recent findings that show the involvement of Grb10 in the regulation of ligand-induced ubiquitination, internalization, and stability of the IGF-IR.
Morrione
Andrea
A
Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Andrea.Morrione@mail.tju.edu
D000818:Animals; D051383:GRB10 Adaptor Protein; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D011506:Proteins / Q000378:metabolism*; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D006133:Growth Substances; D011506:Proteins; D051383:GRB10 Adaptor Protein; D007334:Insulin-Like Growth Factor I; D017526:Receptor, IGF Type 1