Pathologic aspects of AIDS malignancies.
Since the emergence of the HIV pandemic, a close association between HIV infection and the development of a selected group of cancers has been acknowledged. The introduction of highly active antiretroviral therapy, however, has had a dramatic impact on the incidences of several AIDS-defining malignancies. This suggests the possibility of a direct and indirect role of HIV in HIV-related tumor genesis. The aim of this paper is to review the pathology of AIDS-related malignancies, taking into account the pathogenetic mechanisms and their potential for improving the treatment of these tumors.
Bellan
C
C
Department of Human Pathology and Oncology, University of Siena, Siena, Italy.
De Falco
G
G
Lazzi
S
S
Leoncini
L
L
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000235:genetics; D005260:Female; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000235:genetics; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics; D012514:Sarcoma, Kaposi / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000235:genetics