Antimicrobial potentiality of a new non-antibiotic: the cardiovascular drug oxyfedrine hydrochloride.
Ten cardiovascular drugs, having diverse pharmacological action, were screened for possible antimicrobial property against known eight sensitive bacteria, belonging to Gram positive and Gram negative types. Although five drugs failed to show antimicrobial activity and three had moderate antimicrobial action, oxyfedrine HCl and dobutamine were seen to possess pronounced antimicrobial property. Oxyfedrine was further tested in vitro against 471 strains of bacteria from two Gram positive and fourteen Gram negative genera. The minimum inhibitory concentration (MIC) of oxyfedrine was determined by agar dilution method, which ranged from 50-200 microg/ml in most of the strains, while some strains were inhibited at even lower concentrations. In animal experiments, this compound was capable of offering significant protection to Swiss strain of white mice, challenged with 50 median lethal dose (MLD) of a virulent strain of Salmonella typhimurium at concentrations of 15, 30 and 60 microg/mouse. The in vivo results were highly significant according to chi-square test.
Mazumdar
Kaushiki
K
Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India.
Ganguly
Kumkum
K
Kumar
K Asok
KA
Dutta
N K
NK
Chakrabarty
A N
AN
Dastidar
Sujata G
SG
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002316:Cardiotonic Agents / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D010099:Oxyfedrine / Q000494:pharmacology*; D012481:Salmonella Infections, Animal / Q000188:drug therapy; D012486:Salmonella typhimurium / Q000187:drug effects
D000900:Anti-Bacterial Agents; D002316:Cardiotonic Agents; D002317:Cardiovascular Agents; D010099:Oxyfedrine