title: Effects of alpha-pinene odor in different concentrations on stress-induced hyperthermia in rats.
abstract: Stress-induced hyperthermia is observed in animals exposed to stressful conditions. In our previous study, plant-derived fragrances such as green odor and alpha-pinene were shown to suppress this stress response in rats. In the present study, we examined the concentration-dependence of the alpha-pinene effects on stress-induced hyperthermia. Male rats carrying telemetry transmitters were transferred individually to a new cage containing bedding that had been sprayed with 0.3, 0.03, and 0.003% concentrations of alpha-pinene or control solvent. Following transfer to the novel environment, the body temperature increased significantly, and this response was clearly suppressed when the cage was scattered with 0.03% alpha-pinene only. These results suggest that the effect of alpha-pinene on stress-induced hyperthermia can be observed only at a certain concentration.
authors.affiliation: Laboratory of Veterinary Ethology, The University of Tokyo, Japan.
authors.forename: Hitomi
authors.initials: H
authors.lastname: Akutsu
authors.forename: Takefumi
authors.initials: T
authors.lastname: Kikusui
authors.forename: Yukari
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Mori
mesh_terms: D000818:Animals; D000081008:Bicyclic Monoterpenes; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000209:etiology / Q000662:veterinary*; D006799:Housing, Animal; D008297:Male; D039821:Monoterpenes / Q000494:pharmacology*; D009812:Odorants; D051381:Rats; D012376:Rodent Diseases / Q000503:physiopathology*; D012997:Solvents; D013315:Stress, Psychological / Q000503:physiopathology*
chemical_list: D000081008:Bicyclic Monoterpenes; D039821:Monoterpenes; D012997:Solvents; C005451:alpha-pinene