Biosensor profiling of molecular interactions in pharmacology.
Techniques employed to profile the pharmacological properties of a molecule in vitro normally require some type of radio-, enzymatic- or fluorescent-labeling of the ligand and/or the receptor. In contrast, biosensor techniques do not require labeling, and they allow virtually any complex to be screened with minimal assay development. Scientists in both academia and industry are now using biosensors in areas that encompass almost all sectors of drug discovery, diagnostics and the life sciences. Assays have been developed for the analysis of small molecules, proteins, oligonucleotides, bacteriophage, viruses, bacteria and cells. In addition, novel biosensor applications are being developed for the predictive profiling of key pharmacokinetic parameters of a molecule (adsorption, distribution, metabolism, excretion and toxicity).
Cooper
Matthew A
MA
Cambridge Centre for Molecular Recognition, University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, UK. mc221@cam.ac.uk
D000818:Animals; D001692:Biological Transport; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D015195:Drug Design; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D008024:Ligands; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D011485:Protein Binding; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends
D008024:Ligands; D004364:Pharmaceutical Preparations