title: N'Dribala (Cochlospermum planchonii) versus chloroquine for treatment of uncomplicated Plasmodium falciparum malaria.
abstract: The aim of this work was to assess the efficacy of oral N'Dribala (tuberous roots decoction of Cochlospermum planchonii Hook) treatment versus chloroquine in non-severe malaria. The study included 85 patients with uncomplicated Plasmodium falciparum infection in Banfora, Burkina Faso. Forty-six patients that received N'Dribala beverage were compared to 21 patients treated with chloroquine. All patients were monitored with clinical examination and a parasitemia control by Giemsa-stained thick films. N'Dribala appeared safe and statistically as efficient as chloroquine for the treatment of uncomplicated Plasmodium falciparum malaria. At day 5 (D5), 57% of chloroquine-treated and 52% of N'Dribala-treated patients were cured with no detectable parasitemia (parasite density (Pd): 0) and more than 90% of whole patients were asymptomatic. N'Dribala is easily available in this country, cheap, without significant side effects and efficient with a clearly demonstrated activity on Plasmodium falciparum blood stages. This study enhances the traditional use of the Cochlospermum planchonii as alternative therapy for treatment of non-severe malaria.
authors.affiliation: Laboratoire d'Immunologie et de Parasitologie EA-MENRT 2413, Faculté de Pharmacie, 15 Avenue Ch. Flahault, F-34060 Montpellier Cedex 2, France. Francoise.Vical@toulouse.inserm.fr
authors.forename: F
authors.initials: F
authors.lastname: Benoit-Vical
authors.forename: A
authors.initials: A
authors.lastname: Valentin
authors.forename: B
authors.initials: B
authors.lastname: Da
authors.forename: Z
authors.initials: Z
authors.lastname: Dakuyo
authors.forename: L
authors.initials: L
authors.lastname: Descamps
authors.forename: M
authors.initials: M
authors.lastname: Mallié
mesh_terms: D000293:Adolescent; D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use*; D031212:Bixaceae; D002648:Child; D002738:Chloroquine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D016488:Medicine, African Traditional; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D018517:Plant Roots
chemical_list: D000962:Antimalarials; D010936:Plant Extracts; D002738:Chloroquine