title: Using high spectral and spatial resolution bold MRI to choose the optimal oxygenating treatment for individual cancer patients.
abstract: We evaluate whether high spectral and spatial resolution (HiSS) BOLD MRI can correctly rank the effects of three tumor-oxygenating treatments on radiosensitivity in BA1112 rhabdomyosarcomas (n = 5). Significant decreases in spectral linewidth predict that treatment with carbogen gas combined with a perfluorocarbon emulsion will increase radiosensitivity more than either treatment alone, which agrees with the known effects of these treatments on hypoxic fraction. High-resolution maps show that tumor response to each treatment is spatially heterogeneous, and that there is a paradoxical response to the treatments in 7-12% of tumor pixels. Because HiSS MRI emphasizes changes in necrotic and/or hemorrhagic regions, it is more sensitive to oxygenation changes compared to conventional MRI. These results demonstrate that HiSS MRI is a practical, noninvasive method that could be used to choose the treatment that maximizes the size and extent of increases in tumor oxygenation for individual patients.
authors.affiliation: Department of Radiology, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Hania A
authors.initials: HA
authors.lastname: al-Hallaq
authors.forename: Marta A
authors.initials: MA
authors.lastname: Zamora
authors.forename: Brian L
authors.initials: BL
authors.lastname: Fish
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Halpern
authors.forename: John E
authors.initials: JE
authors.lastname: Moulder
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Karczmar
mesh_terms: D000818:Animals; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009368:Neoplasm Transplantation; D010100:Oxygen / Q000008:administration & dosage*; D051381:Rats; D012208:Rhabdomyosarcoma / Q000628:therapy*
chemical_list: D010100:Oxygen