title: A new approach for syntheses of 2',3'-dideoxy-2',3'-dehydronucleosides using 2,2-difluoro-1,3-dimethylimidazolidine (DFI) as a dehydrating reagent.
abstract: We found that 2,2-difluoro-1,3-dimethylimidazolidine (DFI) is useful for not only fluorination but also dehydrating reactions. This dehydrating ability of DFI was applied to the syntheses of dihydrofurans (2) that are possible starting materials for various anticancer or antiviral drugs.
authors.affiliation: Catalysis Science Laboratory, Mitsui Chemicals Inc., Sodegaura-shi, Chiba, Japan. hideki.umetani@mitsui-chem.co.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Umetani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sonoda
authors.forename: Hironori
authors.initials: H
authors.lastname: Komatsu
mesh_terms: D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives*; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D015224:Dideoxynucleosides / Q000138:chemical synthesis*; D015195:Drug Design; D007093:Imidazoles; D007202:Indicators and Reagents
chemical_list: D000970:Antineoplastic Agents; D015224:Dideoxynucleosides; D007093:Imidazoles; D007202:Indicators and Reagents; D000620:Aminoimidazole Carboxamide; C031340:imidazolecarboxamide