Selectin and selectin ligand binding: a bittersweet attraction.
Inhibition of leukocyte migration into target organs has long been an attractive, though challenging, basis for anti-inflammatory strategies. However, to date, the manipulation of leukocyte rolling along blood vessels has not yielded successful new therapies. An important study may now open new avenues in this exciting field of anti-inflammatory therapies by introducing a putative inhibitor of poly-N-acetyllactosamine biosynthesis that affects selectin ligand activity and shows efficacy in a rodent skin inflammation model.
Zollner
Thomas M
TM
Corporate Research Business Area Dermatology, Schering AG, Muellerstrasse 178, D-13342 Berlin, Germany. Thomas.Zollner@Schering.de
Asadullah
Khusru
K
D000117:Acetylglucosamine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D002465:Cell Movement; D003877:Dermatitis, Contact / Q000276:immunology / Q000517:prevention & control*; D019040:E-Selectin / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology; D008562:Membrane Glycoproteins / Q000378:metabolism*; D051379:Mice; D009844:Oligosaccharides / Q000096:biosynthesis; D000080506:Sialyl Lewis X Antigen; D012867:Skin / Q000276:immunology*; D013601:T-Lymphocytes / Q000502:physiology*
D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; C063419:CTAGE1 protein, human; D019040:E-Selectin; D008562:Membrane Glycoproteins; D009844:Oligosaccharides; C084882:P-selectin ligand protein; D000080506:Sialyl Lewis X Antigen; C089178:2-acetamido-1,3,6-tri-O-acetyl-4-deoxy-4-fluoroglucopyranose; D000117:Acetylglucosamine