title: Highly enantioselective conjugate addition of diethylzinc to acyclic enones with fine-tunable phosphite-pyridine ligands.
abstract: A new series of fine-tunable phosphite-pyridine (P,N) ligands derived from (S)-2-amino-2'-hydroxy-6,6'-dimethyl-1,1'-biphenyl and (S)-2-amino-2'-hydroxy-4,4',6,6'-tetramethyl-1,1'-biphenyl was employed in Cu(I)-catalyzed conjugate addition of diethylzinc to acyclic enones. Excellent enantioselectivities (up to 98% ee) and highly catalytic activities were achieved for a variety of acyclic enones.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, People's Republic of China.
authors.forename: Huihui
authors.initials: H
authors.lastname: Wan
authors.forename: Yuanchun
authors.initials: Y
authors.lastname: Hu
authors.forename: Yuxue
authors.initials: Y
authors.lastname: Liang
authors.forename: Shuang
authors.initials: S
authors.lastname: Gao
authors.forename: Junwei
authors.initials: J
authors.lastname: Wang
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Zheng
authors.forename: Xinquan
authors.initials: X
authors.lastname: Hu