Structural characterization of LNA and alpha-L-LNA hybridized to RNA.
LNA and alpha-L-LNA are promising candidates for the development of efficient oligonucleotide-based therapeutic agents. Here, we present a short overview of the structural results we have obtained for LNA:RNA and alpha-L-LNA:RNA hybrids. Specifically, we have shown that LNA acts as an A-type mimic, while alpha-L-LNA acts as a B-type mimic when built into oligonucleotides.
Petersen
Michael
M
Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark. mip@chem.sdu.dk
Nielsen
Jakob T
JT
Bondensgaard
Kent
K
Wengel
Jesper
J
Jacobsen
Jens Peter
JP
D009682:Magnetic Resonance Spectroscopy; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; C477371:locked nucleic acid; D012313:RNA