title: Synthesis and biological activity of 2-aminopurine methylenecyclopropane analogues of nucleosides.
abstract: Synthesis and biological activity of 7- and 9-isomers (Z+E) of methylenecyclopropane analogues of 2-aminopurine nucleosides is described. The (S,Z)-9-isomer is a substrate for xanthine oxidase.
authors.affiliation: Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, USA.
authors.forename: Ruifang
authors.initials: R
authors.lastname: Wang
authors.forename: Xinchao
authors.initials: X
authors.lastname: Chen
authors.forename: John C
authors.initials: JC
authors.lastname: Drach
authors.forename: Earl R
authors.initials: ER
authors.lastname: Kern
authors.forename: Jiri
authors.initials: J
authors.lastname: Zemlicka
mesh_terms: D015075:2-Aminopurine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry; D003521:Cyclopropanes; D007202:Indicators and Reagents; D007536:Isomerism; D013379:Substrate Specificity; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D003521:Cyclopropanes; D007202:Indicators and Reagents; D015075:2-Aminopurine; D014969:Xanthine Oxidase