Presacral multiple cellular schwannomas.
METHODS
Case report. The authors documented a patient presenting with multiple cellular schwannomas along the sciatic nerve. The patient had no stigmas of neurofibromatosis. Thirteen tumors were resected via both anterior and posterior approaches.


OBJECTIVE
To point out that presacral cellular schwannoma can display multiple occurrences.


BACKGROUND
Cellular schwannoma, which is a well-recognized variant of benign schwannoma, is often misdiagnosed as sarcoma. The tumor is usually a solitary lesion.


METHODS
Medical history, physical findings, imaging features, and histologic findings were reviewed in a case of multiple cellular schwannomas in the presacral regions.


RESULTS
A 39-year-old woman without any evidence of neurofibromatosis underwent removal of presacral multiple tumors along the sacral nerve root. Nineteen years after the surgery, the tumors recurred with multiple fashion. Thirteen tumors were resected via both anterior and posterior approaches. Immunohistochemical analysis of S-100 protein and Ki-67 were beneficial with respect to differentiation of cellular schwannoma from malignant peripheral nerve sheath tumor.


CONCLUSIONS
The present case illustrated that multiple cellular schwannomas can develop in nonneurofibromatosis patients.
Ogose
Akira
A
Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Course for Biological Functions and Medical Control, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan. aogose@med.niigata-u.ac.jp
Hotta
Tetsuo
T
Hatano
Hiroshi
H
Kawashima
Hiroyuki
H
Umezu
Hajime
H
Higuchi
Takeshi
T
Endo
Naoto
N
D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008279:Magnetic Resonance Imaging; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D009442:Neurilemmoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D009418:S100 Proteins / Q000032:analysis; D012447:Sacrum; D013125:Spinal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome; D014746:Vimentin / Q000032:analysis
D019394:Ki-67 Antigen; D009418:S100 Proteins; D014746:Vimentin