Pharmacologic features of proton pump inhibitors and their potential relevance to clinical practice.
In conclusion, PPIs differ slightly in their PK and PD properties and in their propensity to interact with other medications. Inhibition of acid secretion is a function of proton pump inhibition, and PPIs work in a similar fashion to achieve this goal. PK/PD principles can be used to optimize PPI therapy when considering issues related to administration, such as timing of drug delivery relative to the number of active pumps and the drug's AUC.
Welage
Lynda S
LS
Department of Clinical Sciences, University of Michigan, College of Pharmacy, Department of Pharmacy Services, Michigan University Medical Center, Ann Arbor, MI, USA. lswelage@umich.edu
D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000494:pharmacology*; D004347:Drug Interactions; D005744:Gastric Acid / Q000378:metabolism*; D005767:Gastrointestinal Diseases / Q000188:drug therapy*; D006801:Humans; D015394:Molecular Structure; D054328:Proton Pump Inhibitors
D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors