title: Total cystectomies in the surgical treatment of rectal cancer with prior chemoradiation: analysis of postoperative morbidity and survival.
abstract: OBJECTIVE
  Curative surgery for rectal cancer seldom requires urinary tract resections. The study investigated morbidity and survival following resection of rectum with total cystectomy following chemoradiation for primary rectal cancer.
  
  
  METHODS
  19 consecutive patients with primary nonresectable rectal cancer undergoing preoperative chemoradiation and operated on by a multidisciplinary team of surgeons.
  
  
  RESULTS
  Morbidity was moderately low, and only five cases required surgical reintervention. No postoperative deaths were observed. Long-term survival in this group of patients compares well with the survival of patients with primarily nonresectable rectal cancer without the involvement of urinary bladder.
  
  
  CONCLUSIONS
  Extended pelvic exenteration due to rectal cancer is relatively safe and in selected patients offers long-term survival and a chance of a cure. Involvement of the urinary bladder does not adversely affect outcome of rectal cancer treatment.
authors.affiliation: Department of Colorectal Cancer, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, ul. W.K. Roentgena 5, 02-781 Warsaw, Poland.
authors.forename: Janusz
authors.initials: J
authors.lastname: Oledzki
authors.forename: Maciej
authors.initials: M
authors.lastname: Chwaliński
authors.forename: Wojciech
authors.initials: W
authors.lastname: Rogowski
authors.forename: Rafał
authors.initials: R
authors.lastname: Sopyło
authors.forename: Marek P
authors.initials: MP
authors.lastname: Nowacki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D003131:Combined Modality Therapy / Q000379:methods; D015653:Cystectomy / Q000379:methods*; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011183:Postoperative Complications; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D016019:Survival Analysis; D015996:Survival Rate; D014547:Urinary Diversion / Q000379:methods
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil