The role of Rel/NF-kappaB transcription factors in B lymphocyte survival.
Among the transcriptional mediators of the various signal transduction pathways that have been shown to regulate lymphocyte apoptosis, Rel/NF-kappaB transcription factors have emerged as key regulators of B cell survival during their differentiation and in their activation by antigens or mitogens. The aim of this review is to bring together recent findings on Rel/NF-kappaB regulation of B cell survival and to present an integrated model of how these transcription factors control apoptosis in a signal and differentiation-stage specific manner. In addition to providing a contemporary view of Rel/NF-kappaB regulated B cell survival, the model described here is aimed to serve as a paradigm for how Rel/NF-kappaB family members control survival in different cell types during differentiation and in response to the plethora of signals that impinge on this master transcriptional regulatory pathway.
Gerondakis
Steve
S
Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, 3050 Vic., Melbourne, Australia. gerondakis@wehi.edu.au
Strasser
Andreas
A
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*; D002470:Cell Survival; D016328:NF-kappa B / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D015398:Signal Transduction; D051841:Transcription Factor RelB; D014157:Transcription Factors / Q000378:metabolism*
D016328:NF-kappa B; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D051841:Transcription Factor RelB