Introduction to micro-analytical systems: bioanalytical and pharmaceutical applications.
This review presents a brief overview of recent developments in miniaturization of analytical instruments utilizing microfabrication technology. The concept 'Micro-Total Analysis Systems micro-TAS)', also termed 'Lab-on-a-chip', and the latest progresses in the development of microfabricated separation devices and on-chip detection techniques are discussed. Applications of micro-analytical methods to bioanalytical and pharmaceutical studies are also described, including chemical reactions, assays, and analytical separations of biomolecules in micro-scale.
Huikko
Katri
K
Department of Pharmacy, PO Box 56, FIN-00014 University of Helsinki, Helsinki, Finland. katri.huikko@helsinki.fi
Kostiainen
Risto
R
Kotiaho
Tapio
T
D000818:Animals; D002623:Chemistry Techniques, Analytical; D002626:Chemistry, Pharmaceutical; D002849:Chromatography, Gas / Q000295:instrumentation; D019075:Electrophoresis, Capillary / Q000295:instrumentation; D006801:Humans; D013058:Mass Spectrometry; D008838:Microcomputers; D008967:Molecular Biology; D036103:Nanotechnology; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet