title: [Enzymatic activity and therapeutic action of pepsin K in chronic gastritis with secretory failure].
abstract: Pepsin K (chicken pepsin) in the test for hemoglobin proteolysis is 1.7 times superior to abomin (porcine pepsin) in the medium pH 2 and 44 times more potent in the medium pH 3. Even in pH 4 chicken pepsin retains its enzymatic activity while porcine pepsin in pH 4 looses its activity. These biochemical findings show that pepsin K is more effective in the treatment of enzymatic insufficiency of the stomach. Intake of 1-3 pepsin K tablets after meal for 4 weeks by 82 patients having chronic gastritis with secretory insufficiency was effective in 75% of patients.
authors.forename: V V
authors.initials: VV
authors.lastname: Kharitonin
authors.forename: G T
authors.initials: GT
authors.lastname: Chernenko
authors.forename: E A
authors.initials: EA
authors.lastname: Sdobnova
authors.forename: A G
authors.initials: AG
authors.lastname: Khliabich
mesh_terms: D000818:Animals; D002908:Chronic Disease; D005260:Female; D005756:Gastritis / Q000188:drug therapy* / Q000201:enzymology*; D005765:Gastrointestinal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D051379:Mice; D008875:Middle Aged; D010434:Pepsin A / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits; D051381:Rats; D016896:Treatment Outcome
chemical_list: D005765:Gastrointestinal Agents; D010434:Pepsin A