title: Synthetic studies towards a novel, chemical stable, abasic site analogue of DNA.
abstract: We synthesized the phosphinate 7 via photoaddition of methanol to the alpha, beta unsaturated deoxyribono lactone as the key step, followed by an Arbusov reaction for the introduction of phosphorous. Precursor 7 serves for the synthesis and incorporation into DNA of a novel chemically stable abasic site analogue that might act as an inhibitor for DNA glycosylases.
authors.affiliation: Department of Chemistry and Biochemistry, University of Bern, Bern, Switzerland.
authors.forename: Caroline
authors.initials: C
authors.lastname: Hirtz
authors.forename: Christian J
authors.initials: CJ
authors.lastname: Leumann
mesh_terms: D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D004260:DNA Repair; D003855:Deoxyribose; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis; D010720:Phosphines
chemical_list: D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D010720:Phosphines; D003855:Deoxyribose; D004247:DNA