Mg2+ homeostasis: the Mg2+nificent TRPM chanzymes.
TRPM6 and TRPM7 are distinct from all other ion channels in that they are composed of linked channel and protein kinase domains. Recent studies demonstrate that these 'chanzymes' are essential for Mg(2+) homeostasis, which is critical for human health and cell viability.
Montell
Craig
C
Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. cmontell@jhmi.edu
D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism*; D011487:Protein Conformation; D011494:Protein Kinases / Q000378:metabolism*; D050053:TRPM Cation Channels
D007473:Ion Channels; D050053:TRPM Cation Channels; C459082:TRPM6 protein, human; D011494:Protein Kinases; D008274:Magnesium