Model of reversible cerebral ischemia in a monkey model.
We have developed a model of reversible cerebral ischemia in a high-level nonhuman primate. By using endovascular techniques, the posterior cerebral artery is permanently occluded with coils, and the ipsilateral middle cerebral artery is temporarily occluded with a balloon. The balloon can be deflated and/or removed to reestablish flow at precise time intervals. Functional imaging of the brain can be performed during occlusion and reperfusion, since the balloon can be deflated or removed in a scanner.
Jungreis
Charles A
CA
Department of Radiology, University of Pittsburgh Medical Center, PA 15213, USA.
Nemoto
Edwin
E
Boada
Fernando
F
Horowitz
Michael B
MB
D000818:Animals; D002545:Brain Ischemia / Q000175:diagnosis / Q000628:therapy; D002533:Cerebral Angiography; D004195:Disease Models, Animal; D008254:Macaca nemestrina