title: SATE (aryl) phosphotriester series. II. Stability studies and physicochemical parameters.
abstract: The stability of phosphotriester derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) bearing a S-pivaloyl-2-thioethyl (tBuSATE) group and various aryl residues derived from L-tyrosine was evaluated in biological media. The results demonstrate that such compounds give rise to intracellular delivery of the parent mononucleotide through esterase and phosphodiesterase hydrolytic steps, successively.
authors.affiliation: Université Montpellier II, UMR 5625 CNRS, Montpellier, France.
authors.forename: G
authors.initials: G
authors.lastname: Coussot
authors.forename: I
authors.initials: I
authors.lastname: Lefebvre
authors.forename: D
authors.initials: D
authors.lastname: Dimalta
authors.forename: S
authors.initials: S
authors.lastname: Peyrottes
authors.forename: A
authors.initials: A
authors.lastname: Pompon
authors.forename: G
authors.initials: G
authors.lastname: Gosselin
authors.forename: C
authors.initials: C
authors.lastname: Périgaud
mesh_terms: D002460:Cell Line; D054306:Dideoxynucleotides; D004355:Drug Stability; D006678:HIV / Q000187:drug effects*; D006801:Humans; D007202:Indicators and Reagents; D013937:Thymidine Kinase / Q000172:deficiency; D013942:Thymine Nucleotides / Q000493:pharmacokinetics; D014443:Tyrosine / Q000031:analogs & derivatives; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D054306:Dideoxynucleotides; D007202:Indicators and Reagents; D013942:Thymine Nucleotides; C057287:3'-azido-3'-deoxythymidine 5'phosphate; D014443:Tyrosine; D015215:Zidovudine; D013937:Thymidine Kinase