The occurrence of 11-oxotetrodotoxin, a rare tetrodotoxin analogue, in the brachycephalidae frog Brachycephalus ephippium.
11-oxoTTX is an analogue 4-5 times more toxic than TTX itself, been rare even in marine animals. Two ions at m/z 320 and 336 corresponding to TTX and 11-oxoTTX (M+H(+)), respectively, were detected in the Brachycephalidae frog Brachycephalus ephippium extracts. The fragment ion pattern of 11-oxoTTX is similar to that TTX, although its possible to verify some specific fragments.
Pires
Osmindo R
OR
Laboratório de Toxinologia, Departamento de Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade de Braslia, Brasília DF 70910-900, Brazil. osmindo@unb.br
Sebben
Antonio
A
Schwartz
Elisabeth Ferroni
EF
Bloch
Carlos
C
Morales
Rodrigo A V
RA
Schwartz
Carlos A
CA
D000664:Amphibian Venoms / Q000737:chemistry*; D000818:Animals; D001001:Anura / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D015394:Molecular Structure; D012015:Reference Standards; D012867:Skin / Q000737:chemistry; D013779:Tetrodotoxin / Q000031:analogs & derivatives* / Q000032:analysis* / Q000737:chemistry / Q000633:toxicity; D014020:Tissue Extracts / Q000737:chemistry*
D000664:Amphibian Venoms; D014020:Tissue Extracts; C104261:11-oxotetrodotoxin; D013779:Tetrodotoxin