The cleavage of the triphosphate bridge of a model for the 5'-cap mRNA promoted by dinuclear bicyclic complexes with metal ions.
Dinuclear bicyclic complexes, which have two active centers, can significantly promote the hydrolysis of the triphosphate bridge in ApppA, a 5'-cap model compound.
Wang
Qi
Q
Department of Chemistry, University of Turku, Turku, Finland. qiwang@utu.fi
Mikkola
Satu
S
Lönnberg
Harri
H
D001643:Bridged Bicyclo Compounds; D002413:Cations, Divalent; D003300:Copper; D015226:Dinucleoside Phosphates / Q000737:chemistry*; D006868:Hydrolysis; D007700:Kinetics; D012315:RNA Caps / Q000737:chemistry* / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic
D001643:Bridged Bicyclo Compounds; D002413:Cations, Divalent; D015226:Dinucleoside Phosphates; D012315:RNA Caps; D012333:RNA, Messenger; C011440:diadenosine triphosphate; D003300:Copper