title: New roles for astrocytes: regulation of CNS synaptogenesis.
abstract: The notion that astrocytes have a profound influence on the function of synapses between CNS neurons implies that the development of synaptic connections and their glial neighbors are controlled by reciprocally acting signals. Currently, however, synaptogenesis is considered a purely neuronal affair. This article summarizes recent experimental evidence suggesting that this may not be the case. Astrocytes may indeed regulate the formation, maturation and maintenance of synapses. The recent advances caution that synapses cannot develop correctly without astrocytes. Further progress on this issue requires new experimental models to identify signaling pathways and to scrutinize the relevance of glia-synapse interactions in vivo.
authors.affiliation: Max-Planck/CNRS Group, UPR 2356, Centre de Neurochimie, 5 rue Blaise Pascal, F-67084 Strasbourg, France. fw-pfrieger@gmx.de
authors.forename: Michal
authors.initials: M
authors.lastname: Slezak
authors.forename: Frank W
authors.initials: FW
authors.lastname: Pfrieger
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism / Q000502:physiology*; D002450:Cell Communication; D002454:Cell Differentiation; D002490:Central Nervous System / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D009474:Neurons / Q000502:physiology; D013569:Synapses / Q000378:metabolism / Q000502:physiology*