title: Renal medullary carcinoma: case report and review of the literature.
abstract: Renal medullary carcinoma is a recently recognized epithelial malignant tumor arising in the renal parenchyma. The tumor is almost exclusive to young black patients with the sickle cell trait. Most patients present with metastatic disease and have a poor prognosis. An Hispanic woman with renal medullary carcinoma who initially responded to chemotherapy with methotrexate, vinblastine, doxorubicin, and cisplatin and survived for 12 months is presented. The clinical, histologic, and radiologic features of this tumor are described, and chemotherapeutic regimens used in this disease are detailed. Treatment modalities have proved largely unsuccessful in the setting of advanced disease. Given the shared demographic, clinical, and radiographic features of these patients, awareness and early diagnosis may prove essential in improving survival.
authors.affiliation: Division of Medical Oncology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
authors.forename: Wanda G
authors.initials: WG
authors.lastname: Noguera-Irizarry
authors.forename: Hanina
authors.initials: H
authors.lastname: Hibshoosh
authors.forename: Kyriakos P
authors.initials: KP
authors.lastname: Papadopoulos
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D018276:Carcinoma, Medullary / Q000175:diagnosis / Q000188:drug therapy* / Q000208:ethnology; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000188:drug therapy* / Q000208:ethnology; D008727:Methotrexate / Q000008:administration & dosage; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D014747:Vinblastine; D004317:Doxorubicin; D002945:Cisplatin; D008727:Methotrexate