The regulation and consequences of immune-mediated cell death in atheromatous diseases.
Atheromatous diseases are lipid and cell-rich vascular disorders that include coronary artery disease (CAD), transplant vascular disease (TVD), and restenosis. Considering the inflammatory nature of these diseases, cytotoxic immune mechanisms such as the FasL and granzyme/perforin pathways most likely play important roles in the development and remodeling of many lesions. Furthermore, although the contributions of immune responses to each disease vary, the correspondent localization of certain mediators and effectors suggests that they may contribute to a spectrum of atheromatous diseases. In this review, the contribution of immune cell-mediated cell death in the onset and pathogenesis of CAD and TVD is examined.
Choy
Jonathan C
JC
UBC McDonald Research Laboratories/The iCAPTUR4E Centre, Department of Pathology and Laboratory Medicine, St. Paul's Hospital/ Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada.
Podor
Thomas J
TJ
Yanagawa
Bobby
B
Lai
John C K
JC
Granville
David J
DJ
Walker
David C
DC
McManus
Bruce M
BM
D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology*; D016923:Cell Death / Q000276:immunology*; D003331:Coronary Vessels / Q000473:pathology; D006801:Humans; D014652:Vascular Diseases / Q000473:pathology