QSAR study on antibacterial activity of sulphonamides and derived Mannich bases.
The paper describes synthesis and comparative study on antibacterial activities of sulphonamides and Mannich bases derived from them. The compounds were screened for their antibacterial activity against various gram-positive and gram-negative bacteria and were analyzed statistically. The results have shown that the compounds are quiet active against pathogens under study and were nontoxic.
Joshi
Sheela
S
School of Chemical Sciences, Devi Ahilya Vishwavidyalaya, Takshila campus, Khandwa Road, Indore (M.P.), India. spjoshi11@rediffmail.com
Khosla
Navita
N
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004121:Dimethyl Sulfoxide; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008352:Mannich Bases / Q000737:chemistry*; D051379:Mice; D008826:Microbial Sensitivity Tests; D021281:Quantitative Structure-Activity Relationship; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity
D000900:Anti-Bacterial Agents; D008352:Mannich Bases; D012997:Solvents; D013449:Sulfonamides; D004121:Dimethyl Sulfoxide