title: Synthesis of new pseudonucleosides containing chiral cyclosulfamides as agycone.
abstract: A series of chiral cyclosulfamides have been synthesized in four steps, starting from N-benzoylaminoacids. Regioselective glycosylation of these pseudopyrimidic heterocycles was carried out after deprotection. Best glycosylation results were obtained by preliminary silylation of cyclosulfamides, and their condensation with a tetraacetylribofuranose and pentaacetylglucopyranose is described, which yielded the pseudonucleosides in a beta-anomeric configuration.
authors.affiliation: Laboratoire de Chimie Bioorganique, Université Badji-Mokhtar, BP12 Annaba, Algeria.
authors.forename: Malika
authors.initials: M
authors.lastname: Berredjem
authors.forename: Nour-Eddine
authors.initials: NE
authors.lastname: Aouf
mesh_terms: D006031:Glycosylation; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013440:Sulfides
chemical_list: D007202:Indicators and Reagents; D009705:Nucleosides; D013440:Sulfides