Autoantigenicity of nucleolar complexes.
Autoantibodies targeting nucleolar autoantigens (ANoA) are most frequently found in sera from patients with systemic sclerosis (SSc, also designated scleroderma) or with SSc overlap syndromes. During the last decade an extensive number of nucleolar components have been identified and this allowed a more detailed analysis of the identity of nucleolar autoantigens. This review intends to give an overview of the molecular composition of the major (families of) autoantigenic nucleolar complexes, to provide some insight into their functions and to summarise the data concerning their autoantigenicity.
Welting
Tim J M
TJ
Department of Biochemistry 161, Nijmegen Centre for Molecular Life Sciences, University of Nijmegen, P.O. Box 9101, NL-6500 HB Nijmegen, The Netherlands.
Raijmakers
Reinout
R
Pruijn
Ger J M
GJ
D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D002466:Cell Nucleolus / Q000276:immunology*; D004722:Endoribonucleases / Q000494:pharmacology; D006801:Humans; D043262:Ribonuclease P / Q000494:pharmacology; D012261:Ribonucleoproteins / Q000737:chemistry
D001324:Autoantigens; D012261:Ribonucleoproteins; D004722:Endoribonucleases; C058330:mitochondrial RNA-processing endoribonuclease; D043262:Ribonuclease P