Effects of proteins from hen egg yolk on human platelet aggregation and blood coagulation.
We studied the effect on both platelet aggregation and blood coagulation, known to be major risk factors in thrombogenesis, of proteins from hen egg yolk (EP). EP potently inhibited collagen-induced human platelet aggregation in a dose-dependent manner. Furthermore, EP has a synergistic effect on the inhibition of human platelet aggregation with both molsidomine, an inhibitor of cGMP-specific phosphodiesterase, and theophylline, an inhibitor of cAMP-specific phosphodiesterase. These results indicate that the active mode of EP might be involved in elevation of the levels of both cGMP and cAMP. Prothrombin time and activated partial thromboplastin time were potently prolonged by EP. These data suggest that EP prolongs the time interval between the conversion of fibrinogen to fibrin. Accordingly, these findings demonstrate that EP might have antithrombotic effects by inhibiting platelet aggregation and fibrin formation.
Cho
Hyun-Jeong
HJ
Department of Biomedical Laboratory Science, College of Biomedical Science and Engineering, Inje University, Korea.
Ham
Hye-Seon
HS
Lee
Dong-Seok
DS
Park
Hwa-Jin
HJ
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology*; D002645:Chickens; D004527:Egg Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D005260:Female; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology*
D004527:Egg Proteins