[Metabolism of endogenous aldehydes: participation in oxidative stress-induced lesions and its age aspects].
This review summarizes the data regarding the synthesis and utilization of endogenous aldehydes and mechanisms of their cytotoxic effect. Peroxidation of polyunsaturated fatty acids is the main source of endogenous aldehydes. There are many different aldehydes generated in the cell. The most abundant is 4-hydroxy-2,3-nonenal synthesized from linoleic acid. Aldehydes may react with proteins and nucleic acids and change their functional properties. Aldehyde utilization mainly occurs in reactions catalysed by aldehyde dehydrogenase, aldehyde reductase and glutathione-S-transferase. The major pathway of their catabolism is accompanied with their conjugation with glutathione. Endogenous aldehyde utilization has its tissue- and age-dependent specificity. The status of aldehyde catabolism can modulate free radical alteration effect on the cell. An adequate stimulation of endogenous aldehyde utilization in the situation of enhancement of free radical generation may promote increasing the cell resistance to oxidative stress injury. Senescence is accompanied by a decrease in endogenous aldehyde utilization intensity in tissues. This could be important in the pathogenesis of age-dependent pathology.
Davydov
V V
VV
Institute of Children and Adolescent Health Protection, Ukrainian Academy of Medical Science, 52A, 50 Let VLKSM str., Kharkov, 61153 Ukraine. dav@nord.vostok.net
Bozhkov
A I
AI
D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress
D000447:Aldehydes; D005231:Fatty Acids, Unsaturated; D005609:Free Radicals