title: A two-stage approach to primary knee arthroplasty in the infected arthritic knee.
abstract: Fourteen patients with either septic knee arthritis or osteomyelitis of the knee with marked joint destruction were treated by resection arthroplasty with the introduction of an antibiotic cement spacer block, appropriate antibiotic therapy, and subsequent primary total knee arthroplasty. Most patients with septic arthritis had chronic infection. Eight patients had positive cultures preoperatively; the remaining patients had either a culture negative purulent aspiration or diagnostic radiographic studies. All patients underwent reconstruction with primary total knee arthroplasty on an average of 3.1 months after the initial stage procedure. Knee Society scores progressed from 46 preoperatively to 89 postoperatively, with an average range of motion from 3 degrees to 105 degrees. At latest clinical follow-up (average, 4.5 years), no patients had recurrence of infection. These data suggest that this method is successful in treating chronically infected knees with a 2-staged arthroplasty.
authors.affiliation: Booth Bartolozzi Balderston Orthopaedics, Pennsylvania Hospital, Philadelphia 19107, USA.
authors.forename: David G
authors.initials: DG
authors.lastname: Nazarian
authors.forename: Dino
authors.initials: D
authors.lastname: de Jesus
authors.forename: Francis
authors.initials: F
authors.lastname: McGuigan
authors.forename: Robert E
authors.initials: RE
authors.lastname: Booth
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D004927:Escherichia coli Infections / Q000601:surgery; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology; D007720:Knee Prosthesis / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000601:surgery*; D013203:Staphylococcal Infections / Q000601:surgery*; D013290:Streptococcal Infections / Q000601:surgery