Anti-oxidant activities of fucosterol from the marine algae Pelvetia siliquosa.
The anti-oxidant activities of fucosterol isolated from the marine algae Pelvetia siliquosa were investigated. Fucosterol exhibited a significant decrease in serum transaminase activities elevated by hepatic damage induced by CCl4-intoxication in rats. Fucosterol inhibited the sGOT and sGPT activities by 25.57 and 63.16%, respectively. Fucosterol showed the increase in the anti-oxidant enzymes such as hepatic cytosolic superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-px) activities by 33.89, 21.56 and 39.24%, respectively, in CCl4-intoxicated rats. These results suggest that fucosterol possess not only the anti-oxidant, but also the hepatoprotective activities in rats.
Lee
Sanghyun
S
Natural Products Research Institute, Seoul National University, Seoul 110-460, Korea.
Lee
Yeon Sil
YS
Jung
Sang Hoon
SH
Kang
Sam Sik
SS
Shin
Kuk Hyun
KH
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002251:Carbon Tetrachloride / Q000008:administration & dosage / Q000009:adverse effects; D002252:Carbon Tetrachloride Poisoning / Q000175:diagnosis; D002374:Catalase / Q000096:biosynthesis / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000473:pathology; D004796:Clinical Enzyme Tests; D004334:Drug Administration Schedule; D056890:Eukaryota / Q000737:chemistry*; D005979:Glutathione Peroxidase / Q000096:biosynthesis / Q000494:pharmacology; D006586:Hexanes; D007274:Injections, Intraperitoneal; D007723:Korea; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000302:isolation & purification / Q000493:pharmacokinetics; D011292:Premedication; D051381:Rats; D017207:Rats, Sprague-Dawley; D012838:Silymarin / Q000008:administration & dosage / Q000493:pharmacokinetics; D013265:Stigmasterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000096:biosynthesis / Q000494:pharmacology; D000637:Transaminases / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000187:drug effects
D000975:Antioxidants; D006586:Hexanes; D010936:Plant Extracts; D012838:Silymarin; C015896:fucosterol; D013265:Stigmasterol; D002251:Carbon Tetrachloride; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000637:Transaminases