[Acute renal failure caused by VIP-secreting tumor].
A 74-year-old woman had secretory diarrhea, severe metabolic acidosis, hypokalemia, hypovolemia, and acute renal failure caused by a pancreatic vasoactive intestinal polypeptide (VIP)-secreting tumor. Vipoma is a rare neuroendocrine tumor. Morbidity and mortality are related to long-standing dehydration and electrolyte and acid-base disturbance resulting in acute renal failure. Diagnosis requires the documentation of large volumes of secretory diarrhea, elevated VIP plasma levels, and the localization of the VIP-secreting tumor. Metastases are present in 50% of patients at the time of diagnosis. Treatment includes correction of volume, electrolyte, and metabolic abnormalities; CVVH during ARF; pharmacotherapy to decrease gastrointestinal secretion; and surgical resection of the vipoma.
Lambertini
D
D
U.O. di Nefrologia ed Emodialisi, Azienda Ospedaliera Carlo Poma, Mantova, Italy. dialisi@ospedale.mantova.it
Bottini
E
E
Talassi
E
E
Tarchini
R
R
Gaetti
L
L
Bellomi
A
A
D058186:Acute Kidney Injury / Q000209:etiology*; D000368:Aged; D005260:Female; D006801:Humans; D010190:Pancreatic Neoplasms / Q000150:complications*; D003969:Vipoma / Q000150:complications*