[Altered cerebral excitability and spreading depression. Causes for the comorbidity of epilepsy and migraine?].
Increased co-occurrence and common clinical aspects of epilepsy and migraine lead to the question of a common pathophysiological model of the diseases. Shared genetic risk factors as an explanation for comorbidity could not be proven. Clinical studies underline the unspecific association of migraine and epilepsy. Comorbidity is based on spreading depression as an expression of altered brain state with neuronal hyperexcitability. In comorbid conditions, therapy with valproate, gabapentin, or topiramate may be effective.
Leniger
T
T
Klinik und Poliklinik für Neurologie, Universitätsklinik Essen. tobias.leniger@uni-essen.de
Diener
H C
HC
Hufnagel
A
A
D000927:Anticonvulsants / Q000627:therapeutic use; D001143:Arousal / Q000187:drug effects / Q000502:physiology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D015897:Comorbidity; D013181:Cortical Spreading Depression / Q000187:drug effects / Q000502:physiology*; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics / Q000503:physiopathology; D012307:Risk Factors
D000927:Anticonvulsants