Synthesis of a base-protected alpha-L-LNA guanine nucleoside.
Synthesis of (1R,3R,4S,7R)-7-hydroxy-1-hydroxymethyl-3-(2-N-isobutyroylguanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane (12), a protected alpha-L-LNA guanine nucleoside, has been accomplished using a convergent synthetic strategy starting from 1,2-di-O-acetylfuranose 4.
Gaubert
Gilles
G
Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark.
Wengel
Jesper
J
D006147:Guanine; D007202:Indicators and Reagents; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis* / Q000737:chemistry
D007202:Indicators and Reagents; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; C477371:locked nucleic acid; D006147:Guanine