title: Hepatic veno-occlusive disease: pathogenesis, diagnosis and treatment.
abstract: Hepatic veno-occlusive disease (VOD) is one of the most serious complications following hematopoietic stem cell transplantation (SCT) and is associated with a very high mortality in its severe form. This review outlines the pathogenesis and clinical features of VOD, with an emphasis on endothelial cell injury and risk factors. The current status and future directions of research for both prophylaxis and treatment are also discussed.
authors.affiliation: Division of Hematology Oncology, Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Martha
authors.initials: M
authors.lastname: Wadleigh
authors.forename: Vincent
authors.initials: V
authors.lastname: Ho
authors.forename: Parisa
authors.initials: P
authors.lastname: Momtaz
authors.forename: Paul
authors.initials: P
authors.lastname: Richardson
mesh_terms: D004730:Endothelium, Vascular / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006504:Hepatic Veno-Occlusive Disease / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D012307:Risk Factors