Preparation of 6-thioguanosine phosphoramidite for oligoribonucleotide synthesis.
6-Thioguanosine phosphoramidite was prepared, using 2,4-dinitrophenyl as protection group for thio-function, and its stability towards conditions of RNA synthesis was investigated. The results show that the monomer was stable under the conditions of RNA synthesis and suitable for incorporation of thioguanine into oligoribonucleotides.
Wang
Yang
Y
School of Life and Health Sciences, Aston University, Birmingham, England.
Lattmann
Eric
E
Zheng
Qinguo
Q
D000577:Amides / Q000737:chemistry; D004355:Drug Stability; D006151:Guanosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D015394:Molecular Structure; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D010756:Phosphoric Acids / Q000737:chemistry; D013872:Thionucleosides / Q000138:chemical synthesis*
D000577:Amides; D007202:Indicators and Reagents; D009843:Oligoribonucleotides; D010756:Phosphoric Acids; D013872:Thionucleosides; D006151:Guanosine; C011067:phosphoramidic acid; C005783:6-thioguanosine