Short-term dynamics of coherence between respiratory movements, heart rate, and arterial pressure fluctuations in severe acute brain disorders.
In our previous study, healthy volunteers showed considerable short-term dynamics and patterns of the coherence of high time resolution between respiratory movements (RESP), heart rate fluctuations (HRF), and arterial blood pressure fluctuations (BPF). These are physiological indicators of autonomic short-term coordination mediated mainly by the brainstem which could be impaired in severe brain disorders. We hypothesized a direct or indirect impairment of these functions by these disorders and examined these patterns in 16 patients suffering from severe brain disorders. We calculated partial and ordinary coherence sequences and found almost the same patterns of coherence sequences as in healthy volunteers, but a distinctly reduced frequency of pattern incidence in patients (2.8+/-1.5/10 min/patient and 9.5+/-2.8/10 min/subject, P<0.05). Furthermore, there is a significantly smaller frequency of HRF-related patterns in patients with poor outcome, compared with those in patients with good outcome (1.8+/-0.8/10 min/patient and 4.5+/-2.7/10 min/patient, P<0.05). We conclude that severe brain disorders reduce physiological short-term dynamics of autonomic coordination patterns in the mean values of patients, but not in every patient.
Zwiener
U
U
Institut für Pathophysiologie, Klinikum der Friedrich-Schiller-Universität, Nonnenplan 2, D-07740 Jena, Germany. uzwi@mti-n.uni-jena.de
Schelenz
Ch
Ch
Bramer
S
S
Hoyer
D
D
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001341:Autonomic Nervous System / Q000503:physiopathology; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D001927:Brain Diseases / Q000503:physiopathology*; D001930:Brain Injuries / Q000503:physiopathology; D003627:Data Interpretation, Statistical; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D002534:Hypoxia, Brain / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration; D012143:Respiratory Physiological Phenomena / Q000187:drug effects; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology; D013997:Time Factors; D016896:Treatment Outcome
D006993:Hypnotics and Sedatives