[Preclinical prognosis of pyracetam and picamilon safety based on acute toxicity data].
A comparative acute toxicity test of the nootropic drugs piracetam and picamilon was performed on rats. The study was based on the principles of integral evaluation of the drug effect upon the functional and behavioral state of animals. It was found that the conventional therapeutic index does not coincide with the actual therapeutic activity range. Piracetam and picamilon, while exhibiting significantly different toxicity, are characterized by approximately equal ranges of the therapeutic activity.
Bugaeva
L I
LI
Institute of Pharmacology, Volgograd State Medical Academy, pl. Pavshikh Bortsov 1a, Volgograd, 400066 Russia.
Spasov
A A
AA
Verovskiĭ
V E
VE
Iezhitsa
I N
IN
D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D018697:Nootropic Agents / Q000633:toxicity*; D010889:Piracetam / Q000633:toxicity*; D051381:Rats; D023382:Toxicity Tests, Acute; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000633:toxicity*
D018697:Nootropic Agents; C044905:nicotinoyl-GABA; D005680:gamma-Aminobutyric Acid; D010889:Piracetam