title: The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens.
abstract: Photorhabdus luminescens is a symbiont of nematodes and a broad-spectrum insect pathogen. The complete genome sequence of strain TT01 is 5,688,987 base pairs (bp) long and contains 4,839 predicted protein-coding genes. Strikingly, it encodes a large number of adhesins, toxins, hemolysins, proteases and lipases, and contains a wide array of antibiotic synthesizing genes. These proteins are likely to play a role in the elimination of competitors, host colonization, invasion and bioconversion of the insect cadaver, making P. luminescens a promising model for the study of symbiosis and host-pathogen interactions. Comparison with the genomes of related bacteria reveals the acquisition of virulence factors by extensive horizontal transfer and provides clues about the evolution of an insect pathogen. Moreover, newly identified insecticidal proteins may be effective alternatives for the control of insect pests.
authors.affiliation: Laboratoire de Génomique des Microorganismes Pathogènes, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris Cedex 15, France.
authors.forename: Eric
authors.initials: E
authors.lastname: Duchaud
authors.forename: Christophe
authors.initials: C
authors.lastname: Rusniok
authors.forename: Lionel
authors.initials: L
authors.lastname: Frangeul
authors.forename: Carmen
authors.initials: C
authors.lastname: Buchrieser
authors.forename: Alain
authors.initials: A
authors.lastname: Givaudan
authors.forename: Séad
authors.initials: S
authors.lastname: Taourit
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Bocs
authors.forename: Caroline
authors.initials: C
authors.lastname: Boursaux-Eude
authors.forename: Michael
authors.initials: M
authors.lastname: Chandler
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Charles
authors.forename: Elie
authors.initials: E
authors.lastname: Dassa
authors.forename: Richard
authors.initials: R
authors.lastname: Derose
authors.forename: Sylviane
authors.initials: S
authors.lastname: Derzelle
authors.forename: Georges
authors.initials: G
authors.lastname: Freyssinet
authors.forename: Sophie
authors.initials: S
authors.lastname: Gaudriault
authors.forename: Claudine
authors.initials: C
authors.lastname: Médigue
authors.forename: Anne
authors.initials: A
authors.lastname: Lanois
authors.forename: Kerrie
authors.initials: K
authors.lastname: Powell
authors.forename: Patricia
authors.initials: P
authors.lastname: Siguier
authors.forename: Rachel
authors.initials: R
authors.lastname: Vincent
authors.forename: Vincent
authors.initials: V
authors.lastname: Wingate
authors.forename: Mohamed
authors.initials: M
authors.lastname: Zouine
authors.forename: Philippe
authors.initials: P
authors.lastname: Glaser
authors.forename: Noël
authors.initials: N
authors.lastname: Boemare
authors.forename: Antoine
authors.initials: A
authors.lastname: Danchin
authors.forename: Frank
authors.initials: F
authors.lastname: Kunst
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001427:Bacterial Toxins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D020637:Photorhabdus / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D020543:Proteome / Q000737:chemistry* / Q000378:metabolism*; D017172:Rhabditoidea / Q000382:microbiology; D016415:Sequence Alignment / Q000379:methods; D020539:Sequence Analysis, Protein / Q000379:methods*; D017386:Sequence Homology, Amino Acid; D013559:Symbiosis / Q000235:genetics
chemical_list: D001427:Bacterial Toxins; D020543:Proteome