title: Adiponectin as a novel determinant of bone mineral density and visceral fat.
abstract: Growing evidence suggests that positive associations between fat mass (FM) and bone mineral density (BMD) are mediated by not only biomechanical but also biochemical factors. Adiponectin is a novel adipocyte-derived hormone that regulates energy homeostasis and has anti-inflammatory and anti-atherogenic effects. Unlike other adipokines such as leptin, adiponectin levels decrease in obesity and type 2 diabetes. The purpose of our study was to investigate associations of serum adiponectin with BMD (DXA and QCT), FM (DXA and QCT), and serum leptin and soluble leptin receptor levels in 38 women and 42 men (age 39-81, BMI 17-55, 86% with type 2 diabetes). After adjusting for age, gender, race, smoking, and diabetes status, serum adiponectin was inversely associated with areal BMD (r = -0.20 to -0.3, all P < 0.01), volumetric BMD (r = -0.35 to -0.44, all P < 0.01), and visceral fat volume (r = -0.30, P < 0.01). These associations remained significant after adjusting for whole body fat mass. The associations of adiponectin with subcutaneous fat volume, whole body FM, and serum leptin level were not significant (all P > 0.1). These data suggest that adiponectin may play a role in the protective effects of visceral fat on BMD.
authors.affiliation: Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. llenchik@wfubmc.edu
authors.forename: L
authors.initials: L
authors.lastname: Lenchik
authors.forename: T C
authors.initials: TC
authors.lastname: Register
authors.forename: F C
authors.initials: FC
authors.lastname: Hsu
authors.forename: K
authors.initials: K
authors.lastname: Lohman
authors.forename: B J
authors.initials: BJ
authors.lastname: Nicklas
authors.forename: B I
authors.initials: BI
authors.lastname: Freedman
authors.forename: C D
authors.initials: CD
authors.lastname: Langefeld
authors.forename: J J
authors.initials: JJ
authors.lastname: Carr
authors.forename: D W
authors.initials: DW
authors.lastname: Bowden
mesh_terms: D052242:Adiponectin; D000273:Adipose Tissue / Q000033:anatomy & histology* / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density / Q000502:physiology*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D010024:Osteoporosis / Q000517:prevention & control; D011506:Proteins / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000097:blood; D054411:Receptors, Leptin
chemical_list: D052242:Adiponectin; D036341:Intercellular Signaling Peptides and Proteins; D020738:Leptin; D011506:Proteins; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin