Peptide-treated stent graft for the treatment of saphenous vein graft lesions: first clinical results.
Percutaneous interventions of degenerated saphenous vein grafts (SVG) are associated with high rates of distal embolic events and in-stent restenosis. A novel ePTFE-covered stent graft has been developed to improve outcomes for these difficult lesions. The stent graft has been treated with a 15-amino acid, cell adhesion peptide (P-15) to promote endothelialization on the inner surface post-implantation. Patients with de novo lesions in SVGs were treated with a peptide-coated ePTFE stent graft. Follow-up data was collected at 30 days, 3 and 6 months. An angiographic core lab analyzed an angiographic follow-up at 6 months.


RESULTS
Procedural success was achieved in all cases. No device-related major adverse cardiac events occurred in-hospital, at 30 days, or at 3 months, despite the lack of distal protection. Six-month restenosis rates were 21%, and were comparable to similar devices.


CONCLUSIONS
The peptide-treated stent graft appears to be a safe and effective treatment for SVG lesions, and has the potential to reduce complications without the use of adjunct distal protection in this patient population.
Hamm
Christian W
CW
Kerckhoff Heart Center, Bad Nauheim, Germany. Christian.Hamm.@kerckhoff.med.uni-giessen.de
Schäachinger
Volker
V
Münzel
Thomas
T
Maikowski
Christian
C
Bonzel
Tassilo
T
Köster
Ralf
R
Rau
Matthias
M
Zeiher
Andreas M
AM
D000368:Aged; D001807:Blood Vessel Prosthesis; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use*; D003094:Collagen / Q000627:therapeutic use*; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006083:Graft Occlusion, Vascular / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000627:therapeutic use*; D011138:Polytetrafluoroethylene / Q000627:therapeutic use*; D011446:Prospective Studies; D012501:Saphenous Vein / Q000473:pathology* / Q000637:transplantation; D015607:Stents; D014656:Vascular Surgical Procedures / Q000295:instrumentation*
D020099:Coated Materials, Biocompatible; D010446:Peptide Fragments; C407062:cell-binding peptide P-15; D011138:Polytetrafluoroethylene; D003094:Collagen