Stress management: MHC class I and class I-like molecules as reporters of cellular stress.
The evolutionarily ancient intracellular stress response protects cells from the effects of external and internal forces which perturb cellular metabolism. Members of the major histocompatibility complex (MHC) class I-like superfamily act as cell surface indicators of the intracellular stress response. Cellular immunity employs these indicators as a cue for elimination of damaged, infected, and malignant cells, promoting the health of the individual and the evolutionary success of the species.
Gleimer
Michael
M
Program in Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Parham
Peter
P
D000818:Animals; D015415:Biomarkers; D018834:Chaperonin 60 / Q000378:metabolism; D019143:Evolution, Molecular; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051379:Mice; D005810:Multigene Family; D011971:Receptors, Immunologic / Q000378:metabolism; D055607:Receptors, Natural Killer Cell; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D015415:Biomarkers; D018834:Chaperonin 60; D015395:Histocompatibility Antigens Class I; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell