[Anti-ischemic properties of the novel antioxidant enoxifol].
The antiischemic properties of the new antioxidant drug enoxifol, representing a derivative of N9-imidazo[1,2-a]benzimidazole, was studied in rats on the models of a double-vessel occlusion of common carotid arteries under normal conditions and on the background of irradiation. In addition, we studied the effect of enoxifol on the rehabilitation of experimental animals in the early reperfusion period after total brain ischemia.
Spasov
A A
AA
Department of Pharmacology, Institute of Pharmacology, Volgograd State Medical Academy, pl. Pavshikh Bortsov 1a, Volgograd, 400066 Russia.
Kosolapov
V A
VA
Ostrovskiĭ
O V
OV
Drozd
V V
VV
Vereshchagin
V K
VK
Sen'chukov
I D
ID
Anisimova
V A
VA
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001157:Arterial Occlusive Diseases / Q000150:complications; D001522:Behavior, Animal / Q000187:drug effects; D001562:Benzimidazoles / Q000494:pharmacology* / Q000627:therapeutic use; D002545:Brain Ischemia / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D002340:Carotid Artery Diseases / Q000150:complications; D003071:Cognition / Q000187:drug effects; D011832:Radiation Injuries / Q000150:complications; D051381:Rats; D015996:Survival Rate
D000975:Antioxidants; D001562:Benzimidazoles; C000589732:enoxifol