The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens.
Photorhabdus luminescens is a symbiont of nematodes and a broad-spectrum insect pathogen. The complete genome sequence of strain TT01 is 5,688,987 base pairs (bp) long and contains 4,839 predicted protein-coding genes. Strikingly, it encodes a large number of adhesins, toxins, hemolysins, proteases and lipases, and contains a wide array of antibiotic synthesizing genes. These proteins are likely to play a role in the elimination of competitors, host colonization, invasion and bioconversion of the insect cadaver, making P. luminescens a promising model for the study of symbiosis and host-pathogen interactions. Comparison with the genomes of related bacteria reveals the acquisition of virulence factors by extensive horizontal transfer and provides clues about the evolution of an insect pathogen. Moreover, newly identified insecticidal proteins may be effective alternatives for the control of insect pests.
Duchaud
Eric
E
Laboratoire de Génomique des Microorganismes Pathogènes, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris Cedex 15, France.
Rusniok
Christophe
C
Frangeul
Lionel
L
Buchrieser
Carmen
C
Givaudan
Alain
A
Taourit
Séad
S
Bocs
Stéphanie
S
Boursaux-Eude
Caroline
C
Chandler
Michael
M
Charles
Jean-François
JF
Dassa
Elie
E
Derose
Richard
R
Derzelle
Sylviane
S
Freyssinet
Georges
G
Gaudriault
Sophie
S
Médigue
Claudine
C
Lanois
Anne
A
Powell
Kerrie
K
Siguier
Patricia
P
Vincent
Rachel
R
Wingate
Vincent
V
Zouine
Mohamed
M
Glaser
Philippe
P
Boemare
Noël
N
Danchin
Antoine
A
Kunst
Frank
F
D000595:Amino Acid Sequence; D000818:Animals; D001427:Bacterial Toxins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D020637:Photorhabdus / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D020543:Proteome / Q000737:chemistry* / Q000378:metabolism*; D017172:Rhabditoidea / Q000382:microbiology; D016415:Sequence Alignment / Q000379:methods; D020539:Sequence Analysis, Protein / Q000379:methods*; D017386:Sequence Homology, Amino Acid; D013559:Symbiosis / Q000235:genetics
D001427:Bacterial Toxins; D020543:Proteome