[Experimental progestogenic activity of novel derivatives of 17alpha-hydroxyprogesterone].
Experiments on infantile female rabbits showed that new 17a-hydroxyprogesterone derivatives (AMOL phenyl propionate, AMOL isopropyl ester) possess a pronounced gestagenic activity. In particular, AMOL isopropyl ester is capable of maintaining pregnancy in ovariectomized animals (Corner-Allen assay).
Korkhov
V V
VV
Laboratory of Pharmacology, Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, Mendeleevskaya Liniya 3, St. Petersburg, 199034 Russia.
Lesik
E A
EA
Petrosian
M A
MA
Ivanov
A P
AP
Tapil'skasia
N I
NI
D019326:17-alpha-Hydroxyprogesterone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D004394:Dydrogesterone / Q000494:pharmacology; D004952:Esters; D005260:Female; D010052:Ovariectomy; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D045167:Progesterone Congeners / Q000494:pharmacology*; D011817:Rabbits
C479060:17alpha-acetoxy-3beta-isopropyloxy-6-methylpregna-4,6-dien-20-one; C479059:17alpha-acetoxy-3beta-phenylpropionyloxy-6-methylpregna-4,6-dien-20-one; D004952:Esters; D045167:Progesterone Congeners; D019326:17-alpha-Hydroxyprogesterone; D004394:Dydrogesterone