title: [Clinical observation of the efficacy of navelbine combined with ifosfamide and cisplatin in the treatment of advanced breast cancer].
abstract: OBJECTIVE
  To observe the efficacy of navelbine combined with ifosfamide and cisplatin in the treatment of advanced breast cancer.
  
  
  METHODS
  Forty cases of pathologically confirmed stages III-IV breast cancer were treated with combined chemotherapy including intravenously infused navelbine (25 mg/m2, days 1 and 8), ifosfamide (1.3 g/m2, days 1 to 5) and cisplatin (20 mg/m2, days 1-5), administered in cycles of 21 days. The therapeutic effect was assessed after at least two cycles were completed.
  
  
  RESULTS
  Complete remission was achieved in 6 cases and partial remission in 16, with an overall responding rate of 55%. The main toxicity was bone marrow suppression manifested by grades III-IV leukopenia occurring at a rate of 40%.
  
  
  CONCLUSIONS
  Navelbine in combination with ifosfamide and cisplatin is effective and safe in the treatment of advanced breast cancer.
authors.affiliation: Department of Oncology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
authors.forename: Hang
authors.initials: H
authors.lastname: Zheng
authors.forename: Rong-cheng
authors.initials: RC
authors.lastname: Luo
authors.forename: Chang-xuan
authors.initials: CX
authors.lastname: You
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008875:Middle Aged; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000077235:Vinorelbine
chemical_list: D014747:Vinblastine; D002945:Cisplatin; D000077235:Vinorelbine; D007069:Ifosfamide