Human gallbladder bile: noninvasive investigation in vivo with single-voxel 1H MR spectroscopy.
Proton (hydrogen 1) magnetic resonance (MR) spectroscopy was used to study model and porcine bile in vitro. The method was subsequently developed to facilitate the acquisition of in vivo 1H MR spectra from the gallbladder bile of 10 human volunteers. Signals attributable to phosphotidylcholine and conjugated bile acid protons were observed in eight of the 10 volunteers. Phosphotidylcholine concentrations were estimated, and five values (mean = 35.8 mmol/L, SD = 9.8) were within the expected range of levels in human bile. Findings in this preliminary investigation indicate that human gallbladder bile can be qualitatively and quantitatively studied noninvasively with 1H MR spectroscopy.
Prescot
Andrew P
AP
Cancer Research UK Clinical Magnetic Resonance Research Group, Institute of Cancer Research, Surrey, England, UK.
Collins
David J
DJ
Leach
Martin O
MO
Dzik-Jurasz
Andrzej S K
AS
D000328:Adult; D000818:Animals; D001646:Bile / Q000737:chemistry*; D005704:Gallbladder / Q000737:chemistry*; D006801:Humans; D008055:Lipids / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008744:Methylamines / Q000032:analysis; D008875:Middle Aged; D013552:Swine
D008055:Lipids; D008744:Methylamines