title: Identification of an anti-inflammatory principle from the stem bark of Millettia versicolor.
abstract: The dichloromethane-soluble fraction of the methanol extract of the stem bark of Millettia versicolor Welw. (Leguminosae) has been shown to possess anti-inflammatory activity. The chromatographic fractionation and subsequent analysis of the spectroscopic data of this extract led to the isolation and identification of 2-acetyl-7-methoxynaphtho[2,3- b]furan-4,9-quinone (1) along with two known quinones. Pharmacological data demonstrate that compound 1 has relevant anti-inflammatory properties whereas the other two isolated compounds do not.
authors.affiliation: Department of Organic Chemistry, University of Yaounde 1, Yaounde, Cameroon.
authors.forename: Maurice Tagatsing
authors.initials: MT
authors.lastname: Fotsing
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Yankep
authors.forename: Dieudonné
authors.initials: D
authors.lastname: Njamen
authors.forename: Z Tanee
authors.initials: ZT
authors.lastname: Fomum
authors.forename: Barthelemy
authors.initials: B
authors.lastname: Nyasse
authors.forename: B
authors.initials: B
authors.lastname: Bodo
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Recio
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Giner
authors.forename: José-Luis
authors.initials: JL
authors.lastname: Ríos
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D033641:Millettia; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D002351:Carrageenan