title: Effects of postoperative administration of ketoprofen or carprofen on short- and long-term results of femoral head and neck excision in dogs.
abstract: OBJECTIVE
  To determine whether postoperative administration of ketoprofen or carprofen had any effects on short- or long-term results of femoral head and neck excision (FHNE) in dogs.
  
  
  METHODS
  Prospective randomized controlled trial.
  
  
  METHODS
  40 client-owned, large-breed dogs undergoing FHNE and 15 healthy large-breed dogs used as controls for hip joint angle measurements and force plate analyses.
  
  
  METHODS
  Dogs undergoing FHNE were treated with ketoprofen, carprofen, or a placebo for 21 days after surgery. Hip joint abduction and extension angles were measured at the end of surgery and 120 days later. Lameness scores were assigned, and force plate analyses were performed on days 3, 15, and 120.
  
  
  RESULTS
  There were no significant differences among treatment groups in regard to hip joint angles or lameness scores. Force plate analysis revealed that dogs in all 3 treatment groups bore consistently less weight on the operated limb than did control dogs for the duration of the study. Dogs receiving ketoprofen had greater peak propulsive force at a walk on day 3 and greater peak vertical force at a walk on day 15 than did dogs receiving the placebo. Treatment of an acute condition and preservation of the lesser trochanter, but not postoperative analgesic administration, were positively associated with ground reaction forces on day 120. Owners of 12 of 31 dogs indicated that the dog's gait worsened for a few days after discontinuation of analgesic administration.
  
  
  CONCLUSIONS
  Administration of ketoprofen or carprofen after surgery was not associated with long-term results of FHNE, probably because of the impact of other factors. Because some owners noticed worsening of the lameness following cessation of analgesic administration in the present study, it is possible that longer administration would have improved long-term results.
authors.affiliation: Département de Sciences Cliniques, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada J2S 7C6.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Grisneaux
authors.forename: Jacques
authors.initials: J
authors.lastname: Dupuis
authors.forename: Philippe
authors.initials: P
authors.lastname: Pibarot
authors.forename: Norbert H
authors.initials: NH
authors.lastname: Bonneau
authors.forename: Benoît
authors.initials: B
authors.lastname: Charette
authors.forename: Diane
authors.initials: D
authors.lastname: Blais
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D002227:Carbazoles / Q000008:administration & dosage*; D004283:Dog Diseases / Q000188:drug therapy* / Q000601:surgery; D004285:Dogs; D004311:Double-Blind Method; D005270:Femur Head / Q000601:surgery; D005271:Femur Head Necrosis / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary; D005272:Femur Neck / Q000601:surgery; D005684:Gait / Q000187:drug effects; D006614:Hindlimb / Q000601:surgery; D006619:Hip Dysplasia, Canine / Q000188:drug therapy / Q000601:surgery; D007660:Ketoprofen / Q000008:administration & dosage*; D007794:Lameness, Animal / Q000188:drug therapy; D010149:Postoperative Pain / Q000188:drug therapy / Q000662:veterinary*; D011184:Postoperative Period; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D016474:Weight-Bearing
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D007660:Ketoprofen; C007005:carprofen