Optimization of antiviral prodrug properties using combinatorial methods.
Some diacid biodegradable synthesis of aziduthymidine (AZT) were synthesized and applied to production of about 60 different derivatives.
Berezovskaya
Yulia V
YV
Department of Biotechnology, Moscow Lomonosov State Academy of Fine Chemical Technology, Moscow, Russia. julia_ber@rambler.ru
Chudinov
Mikhail V
MV
Yurkevich
Alexander M
AM
D000998:Antiviral Agents / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D007202:Indicators and Reagents; D011355:Prodrugs / Q000138:chemical synthesis*; D015215:Zidovudine / Q000031:analogs & derivatives / Q000138:chemical synthesis
D000998:Antiviral Agents; D007202:Indicators and Reagents; D011355:Prodrugs; D015215:Zidovudine