title: [Biological assessment of a new synthetic macromolecular resin class of comfort denture adhesive].
abstract: This article devotes itself to evaluating the biocompatibility of synthetic macromolecular resin class of Comfort denture adhesive, which was developed by the present authors. Acute toxicity, haemolysis, cytotoxicity, sensitization and oral mucous stimulation were tested with standard method (ISO7406-1997 and YY0268-1995). The results showed that no toxic effect was observed with in vivo tests and no cytotoxic effect was observed with in vitro MTT assay. Haemolysis rate of the material (2.95%) indicated good hemaocompatibility. No local mucous membrane irritation reaction was noted after the relevant tests. The developed Comfort denture adhesive exhibited good biocompatiblility.
authors.affiliation: Department of Prosthodontics, School of Stomatology, Sun Yat-sen University, Guangzhou 510055. zhaokirk@163.com
authors.forename: Ke
authors.initials: K
authors.lastname: Zhao
authors.forename: Man
authors.initials: M
authors.lastname: Wang
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Cheng
authors.forename: Qun
authors.initials: Q
authors.lastname: Xiao
authors.forename: Zhian
authors.initials: Z
authors.lastname: Li
authors.forename: Hanting
authors.initials: H
authors.lastname: Cheng
mesh_terms: D000269:Adhesives / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D003781:Denture Retention; D003824:Denture, Complete; D006801:Humans; D008422:Materials Testing; D009061:Mouth Mucosa / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D051381:Rats; D012117:Resins, Synthetic / Q000494:pharmacology*
chemical_list: D000269:Adhesives; D012117:Resins, Synthetic