Association of an A allele for interleukin-10 -627 gene promoter polymorphism with higher susceptibility to endometriosis.
OBJECTIVE
To investigate whether interleukin-10 (IL-10) -627 gene promoter polymorphism could be used as a marker of susceptibility to endometriosis.


METHODS
Women were divided into 2 groups, endometriosis (n = 130) and nonendometriosis (n = 133). Polymorphisms for IL-10 -627 gene promoter were amplified by polymerase chain reaction and detected after restriction enzyme digestion. Genotypes and allelic frequencies in both groups were compared.


RESULTS
Genotype proportions of different IL-10 gene polymorphisms in both groups were not significantly different. Proportions of A homozygote/heterozygote/T homozygote for IL-10 gene polymorphisms in both groups were 50%/40%/10% and 42.1%/38.4%/19.5%. In contrast, allele frequencies for IL-10 gene polymorphism between both groups were significantly different. Alleles A and C for IL-10 gene promoter polymorphism in the groups were 70%/30% and 61.3%/38.7%. A allele was associated with higher susceptibility to endometriosis.


CONCLUSIONS
An association between endometriosis and IL-10 gene promoter polymorphism exists, and the IL-10 -627 A allele is related to a higher susceptibility to endometriosis.
Hsieh
Yao-Yuan
YY
Departments of Obstetrics and Gynecology, of Pediatrics and Medical Genetics and of Family Medicine, China Medical College Hospital, Taichung, Taiwan.
Chang
Chi-Chen
CC
Tsai
Fuu-Jen
FJ
Lin
Cheng-Chieh
CC
Tai
Chin-Tao
CT
Ho
Min
M
D000483:Alleles; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D011110:Polymorphism, Genetic; D017697:Premenopause; D011401:Promoter Regions, Genetic / Q000235:genetics*
D016753:Interleukin-10; D015252:Deoxyribonucleases, Type II Site-Specific; C040158:GTAC-specific type II deoxyribonucleases