Synthesis and biological evaluation of halo-neplanocin A as novel mechanism-based inhibitors of S-adenosylhomocysteine hydrolase.
Halogenated analogues of neplanocin A were synthesized from the key intermediate 1, among which fluoro-neplanocin A was found to be novel mechanism-based irreversible inhibitor of S-Adenosylhomocysteine hydrolase.
Jeong
Lak Shin
LS
College of Pharmacy, Ewha Womans University, Seoul, Korea. lakjeong@ewha.ac.kr
Moon
Hyung Ryong
HR
Park
Jae Gyu
JG
Shin
Dae Hong
DH
Choi
Won Jun
WJ
Lee
Kang Man
KM
Kim
Hea Ok
HO
Chun
Moon Woo
MW
Kim
Hee-Doo
HD
Kim
Joong Hyup
JH
D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D043383:Adenosylhomocysteinase / Q000009:adverse effects*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007700:Kinetics; D008958:Models, Molecular; D008968:Molecular Conformation
D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; C031096:neplanocin A; D043383:Adenosylhomocysteinase; D000241:Adenosine