title: Asymmetric sulfur ylide mediated aziridination: application in the synthesis of the side chain of taxol.
abstract: [reaction: see text] Sulfur ylide methodology has been used to construct the Taxol side chain with a high degree of enantioselectivity via a trans-aziridine followed by stereospecific rearrangement of the trans-benzoylaziridine into a trans-oxazoline.
authors.affiliation: School of Chemistry, Cantock's Close, University of Bristol, Bristol BS8 1TS, UK. v.aggarwal@bristol.ac.uk
authors.forename: Varinder K
authors.initials: VK
authors.lastname: Aggarwal
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Vasse
mesh_terms: D001388:Aziridines / Q000737:chemistry*; D008956:Models, Chemical; D017239:Paclitaxel / Q000138:chemical synthesis*; D013457:Sulfur Compounds / Q000737:chemistry*
chemical_list: D001388:Aziridines; D013457:Sulfur Compounds; D017239:Paclitaxel