Synthesis and antiviral evaluation of beta-D- and beta-L-pentofuranonucleoside derivatives bearing 5-trifluoromethylcytosine as the base.
Beta-D- and beta-L-pentofuranonucleoside derivatives bearing 5-trifluoromethylcytosine as the base have been synthesized. The compounds were tested for their activity against HIV and HBV, but they did not show significant antiviral effect.
Marchand
Arnaud
A
Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS, Université Montpellier II, Place Eugene Bataillon, Montpellier, France.
Mathé
Christophe
C
Gosselin
Gilles
G
D044503:5-Methylcytosine; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D009904:Optical Rotation; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000998:Antiviral Agents; D007202:Indicators and Reagents; D012263:Ribonucleosides; D044503:5-Methylcytosine