Two case studies of highly insoluble plutonium inhalation with implications for bioassay.
Two well characterised Pu inhalation cases show some remarkable similarities between substantially different types of Pu oxide. The circumstances of exposure, therapy, bioassay data, chemical solubility studies and dosimetry associated with these cases suggest that highly insoluble Pu may be more common than previously thought, and can pose significant challenges to bioassay programmes.
Carbaugh
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EH
Pacific Northwest National Laboratory, PO Box 999, MSIN P7-01, Richland, WA 99352, USA. gene.carbaugh@pnl.gov
La Bone
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TR
D000396:Air Pollutants, Radioactive / Q000032:analysis / Q000652:urine; D000576:Americium / Q000032:analysis* / Q000493:pharmacokinetics* / Q000652:urine; D001822:Body Burden; D001842:Bone and Bones / Q000378:metabolism; D003198:Computer Simulation; D005243:Feces / Q000737:chemistry; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis*; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D016273:Occupational Exposure / Q000032:analysis*; D009928:Organ Specificity; D010087:Oxides / Q000032:analysis / Q000145:classification / Q000493:pharmacokinetics / Q000652:urine; D011005:Plutonium / Q000032:analysis* / Q000145:classification / Q000493:pharmacokinetics* / Q000652:urine; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D013909:Thorax / Q000378:metabolism
D000396:Air Pollutants, Radioactive; D010087:Oxides; C034018:americium oxide; D011005:Plutonium; D000576:Americium