Relationship between redox behavior of brain cytochrome oxidase and neurological prognosis.
Currently, no on-line method of assessing cerebral oxygenation is sufficiently accurate to be clinically helpful. In an attempt to find a good predictor of postoperative cerebral outcome, we retrospectively studied the relationship between the redox behavior of cytochrome oxidase (cyt. ox.) during an operation and the neurological prognosis in 83 patients who underwent thoracic aortic surgery. Our data revealed three patterns of change in the redox behavior of cyt. ox. during the operation; the actual pattern exhibited by a given patient showed a highly significant correlation with the neurological prognosis (p < 0.0001). We conclude that the redox behavior of cyt. ox. during an operation is likely to be a good predictor of postoperative cerebral outcome, which implies that brain tissue oxygen sufficiency can be evaluated by near-infrared measurement of cytochrome oxidase (except for that in local regions far from the monitoring site).
Kakihana
Yasuyuki
Y
Division of Intensive Care Medicine, Kagoshima University Hospital, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.
Kuniyoshi
Tamotsu
T
Isowaki
Sumikazu
S
Tobo
Kazumi
K
Nagata
Etsuro
E
Okayama
Naoko
N
Kitahara
Kouichirou
K
Moriyama
Takahiro
T
Omae
Takeshi
T
Kawakami
Masayuki
M
Kanmura
Yuichi
Y
Tamura
Mamoru
M
D000368:Aged; D001921:Brain / Q000201:enzymology* / Q000378:metabolism / Q000503:physiopathology; D001026:Coronary Artery Bypass; D003576:Electron Transport Complex IV / Q000378:metabolism*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D011379:Prognosis; D019265:Spectroscopy, Near-Infrared
D006454:Hemoglobins; D003576:Electron Transport Complex IV; D010100:Oxygen