title: [Mitoxanthrone in the therapy of multiple sclerosis].
abstract: The recent publication of the MIMS study (Mitoxantrone in multiple sclerosis), approval by local health authorities, and the recommendation by the MS Therapy Consensus Group (MSTCG) support the use of mitoxantrone in patients with active multiple sclerosis. This review provides an outline of relevant preclinical and clinical studies, discusses relevant side effects of the compound, and compares its use with other therapeutic approaches to this crippling disorder.
authors.affiliation: Neurologische Klinik, Heinrich-Heine-Universität Düsseldorf.
authors.forename: B C
authors.initials: BC
authors.lastname: Kieseier
authors.forename: R
authors.initials: R
authors.lastname: Gold
authors.forename: H-P
authors.initials: HP
authors.lastname: Hartung
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D017277:Drug Approval; D006801:Humans; D008942:Mitoxantrone / Q000009:adverse effects / Q000627:therapeutic use*; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000188:drug therapy*; D009460:Neurologic Examination / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D008942:Mitoxantrone