title: [Drug treatment of sleep disorders in the elderly].
abstract: Changes in the pattern of sleep, e.g. more frequent nocturnal awakenings, are normal in the elderly. There is also a greater incidence of medical and psychiatric sleep disorders (depression, dementia). Initially, a thorough diagnostic assessment should be performed in order to identify disorders which can be treated specifically. For the symptomatic drug treatment of insomnias, the specific metabolic and pharmacokinetic, as well as possible interactions, should be considered. The new benzodiazepine receptor agonists (zopiclone, zolpidem and zaleplone), with their favourable risk-benefit profile, can be considered as first-choice treatments in elderly patients; in general, they should be preferred to the classical benzodiazepines. When a longer treatment is necessary, certain (non-anticholinergic) antidepressants and neuroleptics can be considered (the latter especially in cases of abnormal nocturnal behaviour). Herbal drugs and other hypnotically active compounds play a secondary role. Drug treatment of insomnia should always be carried out in the context of a general treatment plan which also includes non-pharmacological elements. In elderly patients, "chronotherapeutic" methods, which accentuate the sleep-wake rhythm, are of crucial importance.
authors.affiliation: Schlafmedizinisches Zentrum, Klinik und Poliklinik für Psychiatrie und Psychotherapie, Technische Universität, München, Germany. mhwiegand@lrz.tum.de
authors.forename: M H
authors.initials: MH
authors.lastname: Wiegand
mesh_terms: D000081:Acetamides / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D053961:Azabicyclo Compounds; D001569:Benzodiazepines / Q000627:therapeutic use; D019454:Chronotherapy / Q000379:methods*; D003131:Combined Modality Therapy; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008517:Phytotherapy / Q000379:methods; D010879:Piperazines / Q000627:therapeutic use; D010818:Practice Patterns, Physicians'; D011725:Pyridines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D007319:Sleep Initiation and Maintenance Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000628:therapy; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000628:therapy; D000077334:Zolpidem
chemical_list: D000081:Acetamides; D000928:Antidepressive Agents; D014150:Antipsychotic Agents; D053961:Azabicyclo Compounds; D006993:Hypnotics and Sedatives; D010879:Piperazines; D011725:Pyridines; D011743:Pyrimidines; C515050:zopiclone; D001569:Benzodiazepines; D000077334:Zolpidem; C085665:zaleplon