title: Identification of quorum-sensing-regulated genes of Burkholderia cepacia.
abstract: Quorum sensing is a regulatory mechanism (operating in response to cell density) which in gram-negative bacteria usually involves the production of N-acyl homoserine lactones (HSL). Quorum sensing in Burkholderia cepacia has been associated with the regulation of expression of extracellular proteins and siderophores and also with the regulation of swarming and biofilm formation. In the present study, several quorum-sensing-controlled gene promoters of B. cepacia ATCC 25416 were identified and characterized. A total of 28 putative gene promoters show CepR-C(8)-HSL-dependent expression, suggesting that quorum sensing in B. cepacia is a global regulatory system.
authors.affiliation: Bacteriology Group, International Centre for Genetic Engineering and Biotechnology, 34012 Trieste, Italy. venturi@icgeb.org
authors.forename: Claudio
authors.initials: C
authors.lastname: Aguilar
authors.forename: Arianna
authors.initials: A
authors.lastname: Friscina
authors.forename: Giulia
authors.initials: G
authors.lastname: Devescovi
authors.forename: Milan
authors.initials: M
authors.lastname: Kojic
authors.forename: Vittorio
authors.initials: V
authors.lastname: Venturi
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D016956:Burkholderia cepacia / Q000235:genetics* / Q000378:metabolism; D003001:Cloning, Molecular; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D006714:Homoserine / Q000031:analogs & derivatives* / Q000096:biosynthesis; D007783:Lactones; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; C117246:CepR protein, Burkholderia; D007783:Lactones; C091088:N-octanoylhomoserine lactone; D006714:Homoserine