title: Structure elucidation of Sch 538415, a novel acyl carrier protein synthase inhibitor from a microorganism.
abstract: A novel acyl carrier protein synthase inhibitor, Sch 538415 (1), was isolated from an unidentified bacterial microbe. Structure elucidation of 1 was accomplished based on analysis of spectroscopic data including UV, MS and 2D-NMR spectra. Compound 1 exhibited inhibitory activity in the acyl carrier protein synthase (AcpS) assay with an IC(50) value of 4.19 microM and showed antibacterial activity against Staphylococcus aureus in the agar diffusion assay.
authors.affiliation: Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. min.chu@spcorp.com
authors.forename: Min
authors.initials: M
authors.lastname: Chu
authors.forename: Ronald
authors.initials: R
authors.lastname: Mierzwa
authors.forename: Ling
authors.initials: L
authors.lastname: Xu
authors.forename: Shu-Wei
authors.initials: SW
authors.lastname: Yang
authors.forename: Ling
authors.initials: L
authors.lastname: He
authors.forename: Mahesh
authors.initials: M
authors.lastname: Patel
authors.forename: Jill
authors.initials: J
authors.lastname: Stafford
authors.forename: David
authors.initials: D
authors.lastname: Macinga
authors.forename: Todd
authors.initials: T
authors.lastname: Black
authors.forename: Tze-Ming
authors.initials: TM
authors.lastname: Chan
authors.forename: Vincent
authors.initials: V
authors.lastname: Gullo
mesh_terms: D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D001419:Bacteria / Q000737:chemistry; D002853:Chromatography, Liquid; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008970:Molecular Weight; D011500:Protein Synthesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011809:Quinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D017855:Transferases (Other Substituted Phosphate Groups) / Q000037:antagonists & inhibitors*
chemical_list: D001372:Aza Compounds; D011500:Protein Synthesis Inhibitors; D011809:Quinones; C486843:Sch 538415; D017855:Transferases (Other Substituted Phosphate Groups); C021364:holo-(acyl-carrier-protein) synthase