Recent progress in the design of selectin inhibitors.
The selectins are a family of cell-adhesion proteins that mediate the early stages of leukocyte recruitment from the blood stream to sites of tissue damage through recognition of the carbohydrate epitope sialyl Lewis(x) (sLe(x)). Current development of small molecule based inhibitors of this process and their clinical potential to address numerous acute and chronic diseases are explored.
Chhabra
Siri Ram
SR
School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Rahim
Aisyah S Abdul
AS
Kellam
Barrie
B
D000818:Animals; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008024:Ligands; D018716:Molecular Mimicry; D019087:Selectins / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology
D002241:Carbohydrates; D008024:Ligands; D019087:Selectins