title: Putative caveolin-binding sites in SARS-CoV proteins.
abstract: OBJECTIVE
  To obtain the information of protein-protein interaction between the SARS-CoV proteins and caveolin-1, identify the possible caveolin-binding sites in SARS-CoV proteins.
  
  
  METHODS
  On the basis of three related caveolin-binding motifs, amino acid motif search was employed to predict the possible caveolin-1 related interaction domains in the SARS-CoV proteins. The molecular modeling and docking simulation methods were used to confirm the interaction between caveolin-1 and SARS-CoV proteins.
  
  
  RESULTS
  Thirty six caveolin-binding motifs in the SARS-CoV proteins have been mapped out using bioinformatics analysis tools. Molecular modeling and simulation have confirmed 8 caveolin-binding sites. These caveolin-binding sites located in replicase 1AB, spike protein, orf3 protein, and M protein, respectively.
  
  
  CONCLUSIONS
  Caveolin-1 may serve as a possible receptor of the SARS-CoV proteins, which may be associated with the SARS-CoV infection, replication, assembly, and budding.
authors.affiliation: School of Public Health, Fudan University, Shanghai 200032, China. qccai@smmu.edu.cn
authors.forename: Quan-Cai
authors.initials: QC
authors.lastname: Cai
authors.forename: Qing-Wu
authors.initials: QW
authors.lastname: Jiang
authors.forename: Gen-Ming
authors.initials: GM
authors.lastname: Zhao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Guo
authors.forename: Guang-Wen
authors.initials: GW
authors.lastname: Cao
authors.forename: Teng
authors.initials: T
authors.lastname: Chen
mesh_terms: D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D001665:Binding Sites; D051242:Caveolin 1; D022461:Caveolins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008562:Membrane Glycoproteins / Q000378:metabolism; D008958:Models, Molecular; D011485:Protein Binding; D045473:Severe acute respiratory syndrome-related coronavirus / Q000737:chemistry*; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins / Q000378:metabolism; D014764:Viral Proteins / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D051242:Caveolin 1; D022461:Caveolins; D008562:Membrane Glycoproteins; D064370:Spike Glycoprotein, Coronavirus; D014759:Viral Envelope Proteins; D014764:Viral Proteins