Synthesis and biological activity of 2-aminopurine methylenecyclopropane analogues of nucleosides.
Synthesis and biological activity of 7- and 9-isomers (Z+E) of methylenecyclopropane analogues of 2-aminopurine nucleosides is described. The (S,Z)-9-isomer is a substrate for xanthine oxidase.
Wang
Ruifang
R
Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, USA.
Chen
Xinchao
X
Drach
John C
JC
Kern
Earl R
ER
Zemlicka
Jiri
J
D015075:2-Aminopurine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry; D003521:Cyclopropanes; D007202:Indicators and Reagents; D007536:Isomerism; D013379:Substrate Specificity; D014969:Xanthine Oxidase / Q000378:metabolism
D000998:Antiviral Agents; D003521:Cyclopropanes; D007202:Indicators and Reagents; D015075:2-Aminopurine; D014969:Xanthine Oxidase