title: Synthesis of halogenated 9-(dihydroxycyclopent-4'-enyl) adenines and their inhibitory activities against S-adenosylhomocysteine hydrolase.
abstract: Novel halovinyl analogues of neplanocin A without 4'-hydroxymethyl group were easily synthesized starting from D-ribose via cyclopentenone 5 as a key intermediate and their inhibitory activity against SAH hydrolase was assayed.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seoul, South Korea. lakjeong@ewha.ac.kr
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
authors.forename: Jae Gyu
authors.initials: JG
authors.lastname: Park
authors.forename: Won Jun
authors.initials: WJ
authors.lastname: Choi
authors.forename: Hyung Ryong
authors.initials: HR
authors.lastname: Moon
authors.forename: Kang Man
authors.initials: KM
authors.lastname: Lee
authors.forename: Hea Ok
authors.initials: HO
authors.lastname: Kim
authors.forename: Hee-Doo
authors.initials: HD
authors.lastname: Kim
authors.forename: Moon Woo
authors.initials: MW
authors.lastname: Chun
authors.forename: Hea-Young
authors.initials: HY
authors.lastname: Park
authors.forename: Kilhyoun
authors.initials: K
authors.lastname: Kim
authors.forename: Yhun Y
authors.initials: YY
authors.lastname: Sheen
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000241:Adenosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D043383:Adenosylhomocysteinase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; C031096:neplanocin A; D043383:Adenosylhomocysteinase; D000225:Adenine; D000241:Adenosine