Computer-aided tissue engineering: application to biomimetic modelling and design of tissue scaffolds.
Computer-aided tissue engineering (CATE) enables many novel approaches in modelling, design and fabrication of complex tissue substitutes with enhanced functionality and improved cell-matrix interactions. Central to CATE is its bio-tissue informatics model that represents tissue biological, biomechanical and biochemical information that serves as a central repository to interface design, simulation and tissue fabrication. The present paper discusses the application of a CATE approach to the biomimetic design of bone tissue scaffold. A general CATE-based process for biomimetic modelling, anatomic reconstruction, computer-assisted-design of tissue scaffold, quantitative-computed-tomography characterization, finite element analysis and freeform extruding deposition for fabrication of scaffold is presented.
Sun
Wei
W
Laboratory for Computer-Aided Tissue Engineering, Department of Mechanical Engineering and Mechanics, College of Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA. sunwei@drexel.edu
Starly
Binil
B
Darling
Andrew
A
Gomez
Connie
C
D001672:Biocompatible Materials / Q000138:chemical synthesis; D001696:Biomechanical Phenomena; D032701:Biomimetics / Q000379:methods; D018786:Bone Substitutes; D017076:Computer-Aided Design; D008567:Membranes, Artificial; D008953:Models, Anatomic; D023822:Tissue Engineering / Q000379:methods*
D001672:Biocompatible Materials; D018786:Bone Substitutes; D008567:Membranes, Artificial