How to make a relationship last: release sites with different levels of commitment.
Stimulus-induced changes in synaptic strength endure for periods ranging from minutes to days. In this issue of Neuron, Kim et al. show that two distinct types of synaptic change-synaptic vesicle movement into previously empty varicosities and formation of new varicosities-may determine intermediate- versus long-term synaptic facilitation.
Kaczmarek
Leonard K
LK
Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
D000818:Animals; D006801:Humans; D009475:Neurons, Afferent / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*; D013572:Synaptic Vesicles / Q000378:metabolism*