New way to deliver fluids: endoscopic jet injection into the beagle prostate.
OBJECTIVE
Local therapy of the prostate could have a role in the treatment of benign prostatic hyperplasia as well as prostate cancer. Endoscopic jet injection could simplify these treatments. We evaluated the tissue effects of endoscopic jet injection in an animal model.


METHODS
An endoscopic jet injector was developed. In 12 beagle dogs the prostate was injected with single shot and continuous mode jet injection. Macroscopic and histological analysis was performed 0, 2 and 14 days after jet injection.


RESULTS
Jet injection allowed complete penetration of the beagle prostate. The single shot technique resulted in only minimal tissue effects. However, the continuous mode led to major tissue damage, even complete aseptic necrosis, in the injected area.


CONCLUSIONS
A new method for endoscopic application of fluids is described. Depending on the jet injection technique it could be used to apply pharmaceutical agents or plasmids, and/or induce aseptic necrosis.
Haupt
Gerald
G
Department of Urology, University of Cologne, Cologne, Germany.
Haupt
Angela
A
Richter
Klaus-Dieter
KD
Senge
Theodor
T
D000818:Animals; D001284:Atrophy; D004285:Dogs; D019723:Endoscopes; D006470:Hemorrhage / Q000473:pathology; D007277:Injections, Jet / Q000295:instrumentation*; D007964:Leukocytosis / Q000473:pathology; D008297:Male; D008751:Methylene Blue / Q000008:administration & dosage; D009336:Necrosis; D011467:Prostate / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000473:pathology*; D012007:Rectum / Q000473:pathology; D000267:Tissue Adhesions; D019459:Urothelium / Q000473:pathology
D008751:Methylene Blue