title: [Thrombophilia as a risk factor for central retinal vein occlusion].
abstract: Central retinal vein occlusion is associated with systemic conditions, such as arterial hypertension, diabetes, hypercholesterolemia, but also with certain hypercoagulability states (thrombophilia). Growing evidence indicates, that the presence of antiphospholipid antibodies and elevated plasma homocysteine levels predispose to central retinal vein occlusion. In younger patients, factor V Leiden (Arg506Gln) could increase the risk of this disease. Other probable causes of thrombophilia related to retinal vein occlusion include increased levels of plasminogen activator inhibitor 1 and lipoprotein (a), which impair fibrinolysis.
authors.affiliation: II Katedry Chorób Wewnetrznych Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
authors.forename: Anetta
authors.initials: A
authors.lastname: Undas
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kubicka-Trzaska
mesh_terms: D017152:Antibodies, Antiphospholipid / Q000097:blood; D048909:Diabetes Complications; D005165:Factor V / Q000032:analysis; D006710:Homocysteine / Q000097:blood; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D006973:Hypertension / Q000150:complications; D017270:Lipoprotein(a) / Q000097:blood; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D012170:Retinal Vein Occlusion / Q000209:etiology*; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis*
chemical_list: D017152:Antibodies, Antiphospholipid; D017270:Lipoprotein(a); D017395:Plasminogen Activator Inhibitor 1; C095381:factor V Leiden; D006710:Homocysteine; D005165:Factor V