title: Synthesis and antiviral evaluation of ribavirin congeners containing a hexitol moiety.
abstract: Several ribavirin congeners containing a hexitol moiety were prepared via ring opening of two different epoxides with the methylcarboxylate ester of triazole and further elaboration. Unfortunately, none of the newly synthesized compounds displayed appreciable antiviral activity.
authors.affiliation: Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium. vanaerschot@rega.kuleuven.ac.be
authors.forename: A
authors.initials: A
authors.lastname: Van Aerschot
authors.forename: G
authors.initials: G
authors.lastname: Schepers
authors.forename: R
authors.initials: R
authors.lastname: Busson
authors.forename: J
authors.initials: J
authors.lastname: Neyts
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: P
authors.initials: P
authors.lastname: Herdewijn
mesh_terms: D000438:Alcohols; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D016174:Hepacivirus / Q000187:drug effects*; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D014230:Triazoles
chemical_list: D000438:Alcohols; D000998:Antiviral Agents; D007202:Indicators and Reagents; D014230:Triazoles; D012254:Ribavirin