Effect of Hibiscus rosa sinensis Linn. ethanol flower extract on blood glucose and lipid profile in streptozotocin induced diabetes in rats.
Blood glucose and total lipid levels were determined in streptozotocin induced diabetic rats after oral administration of an ethanol flower extract of Hibiscus rosa sinensis. A comparable hypoglycemic effect was evidenced from the data obtained after 7 and 21 days of oral administration of the extract and glibenclamide. Maximal diminution in blood glucose (41-46%) and insulin level (14%) was noticed after 21 days. The extract lowered the total cholesterol and serum triglycerides by 22 and 30%, respectively. The increase in HDL-cholesterol was much higher (12%) under the influence of the extract as compared to that of glibenclamide (1%). The hypoglycemic activity of this extract is comparable to that of glibenclamide but is not mediated through insulin release. Other possible mechanisms are discussed.
Sachdewa
Archana
A
Department of Chemistry, Faculty of Science, Dayalbagh Educational Institute, Dayalbagh, Agra 282-005, India.
Khemani
L D
LD
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D035264:Flowers; D005952:Glucose-6-Phosphatase / Q000097:blood; D005905:Glyburide / Q000494:pharmacology; D031584:Hibiscus; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000819:agonists / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D013311:Streptozocin; D014508:Urea / Q000097:blood
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D010936:Plant Extracts; D013311:Streptozocin; D014508:Urea; D005952:Glucose-6-Phosphatase; D005905:Glyburide