Bicyclic nucleoside inhibitors of varicella-zoster virus: 5'-chloro and 3'-chloro derivatives.
We have recently discovered bicyclic furopyrimidines as potent and selective inhibitors of VZV. In order to investigate the structural requirements for antiviral activity we have succesfully synthesised some 3'-chloro and 5'-chloro derivatives. The compounds have been tested against VZV and CMV, but displayed no significant in vitro activity.
Luoni
G
G
Welsh School of Pharmacy, Cardiff University, Cardiff, UK. luonig@cf.ac.uk
McGuigan
C
C
Andrei
G
G
Snoeck
R
R
De Clercq
E
E
Balzarini
J
J
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects; D015195:Drug Design; D005459:Fluorides; D014645:Herpesvirus 3, Human / Q000187:drug effects*; D008958:Models, Molecular; D015394:Molecular Structure; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014994:Xylose
D000998:Antiviral Agents; D001643:Bridged Bicyclo Compounds; D011741:Pyrimidine Nucleosides; D014994:Xylose; D005459:Fluorides