title: Polycystic ovaries, precocious puberty and acquired hypothyroidism: The Van Wyk and Grumbach syndrome.
abstract: Long-standing acquired hypothyroidism can rarely be associated with precocious puberty and polycystic ovaries. The authors report such a case, which responded to the simple replacement of thyroid hormone. It is important to look for hypothyroidism in girls with ovarian masses and precocious puberty to avoid surgery on the ovaries.
authors.affiliation: Department of Pediatric Surgery, Kasturba Medical College, Manipal, Karnataka, India.
authors.forename: Anindya
authors.initials: A
authors.lastname: Chattopadhyay
authors.forename: Vijaya
authors.initials: V
authors.lastname: Kumar
authors.forename: Mohan
authors.initials: M
authors.lastname: Marulaiah
mesh_terms: D002648:Child; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000188:drug therapy; D011629:Puberty, Precocious / Q000150:complications* / Q000188:drug therapy; D013577:Syndrome; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D013974:Thyroxine