title: Suppression of exonucleolytic degradation of double-stranded DNA and inhibition of Exonuclease III by PNA.
abstract: Degradation of double-stranded DNA by Exonuclease III in the presence of complementary anti-parallel PNA was studied. It was found for the first time that the PNA suppresses the degradation of dsDNA in a sequence-specific manner as well as inhibits the activity of Exonuclease III in a non-specific way.
authors.affiliation: Division of Organic and Bioorganic Chemistry, MBB, Karolinska Institute, Stockholm, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Slaitas
authors.forename: C
authors.initials: C
authors.lastname: Ander
authors.forename: Z
authors.initials: Z
authors.lastname: Földes-Papp
authors.forename: R
authors.initials: R
authors.lastname: Rigler
authors.forename: E
authors.initials: E
authors.lastname: Yeheskiely
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005090:Exodeoxyribonucleases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D020135:Peptide Nucleic Acids / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D020135:Peptide Nucleic Acids; D004247:DNA; D005090:Exodeoxyribonucleases; C020133:exodeoxyribonuclease III