Effects of the contrast medium iopromide on renal hemodynamics and oxygen tension in the diabetic rat kidney.
We investigated the effects of the contrast medium (CM) iopromide on regional renal blood flow and oxygen tension (pO2) in the streptozotocin (STZ)-induced diabetic Wistar Furth rats.


RESULTS
In normoglycemic rats, CM injection induced a transient decrease followed by an increase in renal cortical blood flow (CBF), whereas CBF increased directly in the diabetic animals. Renal outer medullary blood flow (OMBF) increased in controls, while it decreased in the diabetic animals following CM injection. In control rats a marked initial decrease in OM pO2 following injection of CM was observed. In animals diabetic for 4 weeks only a slight decrease was seen, whereas in 9-week diabetic animals a persistent increase was recorded.


CONCLUSIONS
An altered oxygen tension and hemodynamic response to CM was found in diabetic rats. If these disturbances may contribute to the development of renal dysfunction by CM in the diabetic rat kidney remains to be elucidated.
Palm
Fredrik
F
Department of Medical Cell Biology, Department of Diagnostic Radiology, Biomedical Center, Box 571, SE-751 23, Uppsala University, Uppsala, Sweden.
Carlsson
Per-Ola
PO
Fasching
Angelica
A
Hellberg
Olof
O
Nygren
Anders
A
Hansell
Peter
P
Liss
Per
P
D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D007472:Iohexol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism* / Q000502:physiology; D008297:Male; D051381:Rats; D011920:Rats, Inbred WF; D013311:Streptozocin
D003287:Contrast Media; D007472:Iohexol; D013311:Streptozocin; C038192:iopromide