Indium-mediated tandem radical addition-cyclization-trap reactions in aqueous media.
[reaction: see text] Tandem carbon-carbon bond-forming reactions were studied by using indium as a single-electron-transfer radical initiator. The radical addition-cyclization-trap reaction of a substrate having a vinyl sulfonamide group and an olefin moiety proceeded smoothly in aqueous media. The radical addition-cyclization reaction of hydrazone gave the functionalized cyclic products.
Ueda
Masafumi
M
Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan.
Miyabe
Hideto
H
Nishimura
Azusa
A
Miyata
Okiko
O
Takemoto
Yoshiji
Y
Naito
Takeaki
T