title: Salivary duct carcinoma of submandibular gland with trigeminal nerve invasion to intracranium.
abstract: Salivary duct carcinoma is a rare and invasive malignant tumour with rapid distant metastasis and dismal prognosis. Clinically, perineural invasion of the salivary duct carcinoma is commonly noted. Here, we present a case of salivary duct carcinoma of submandibular gland origin with perineural invasion of the trigeminal nerve proximal to the intracranium, that was well demonstrated by a magnetic resonance image (MRI) and was consistent with the clinical presentation. This case received radical resection and radiotherapy with inclusion of the skull base within the field. There was no tumour recurrence and distant metastasis 24 months post-operatively.
authors.affiliation: Department of Otolaryngology, Chang Gung University, Chang Gung Memorial Hospital in Kaohsiung, Taiwan.
authors.forename: Chia-Hug
authors.initials: CH
authors.lastname: Li
authors.forename: Chih-Ying
authors.initials: CY
authors.lastname: Su
authors.forename: Chih-Yen
authors.initials: CY
authors.lastname: Chien
authors.forename: Chung-Feng
authors.initials: CF
authors.lastname: Hwang
authors.forename: Hsiu-Yu
authors.initials: HY
authors.lastname: Huang
mesh_terms: D044584:Carcinoma, Ductal / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D019291:Skull Base; D013365:Submandibular Gland Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy; D014057:Tomography, X-Ray Computed; D014276:Trigeminal Nerve / Q000000981:diagnostic imaging / Q000473:pathology*