Ac'septin' a signal: kinase regulation by septins.
Budding yeast monitor shape and the assembly of cytoskeletal structures and convey this information to regulators of cell division, but the molecular mechanisms responsible for monitoring and interpreting spatial information about the cytoskeleton remain poorly understood. A paper in the September issue of Molecular Cell shows that direct binding of components of the septin cytoskeleton may relieve autoinhibition of a conserved checkpoint kinase, creating a simple molecular device for sensing septin cytoskeleton organization.
Moffat
Jason
J
Department of Medical Genetics and Microbiology, University of Toronto, 1 Kings College Circle, Toronto, Ontario M5S 1A8, Canada.
Andrews
Brenda
B
D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000502:physiology*; D008954:Models, Biological; D010770:Phosphotransferases / Q000378:metabolism*; D004718:Saccharomycetales / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D018797:Cell Cycle Proteins; D010770:Phosphotransferases; D019204:GTP-Binding Proteins