Targeting apoptosis in acute tubular injury.
Recent research has shown that apoptosis and its regulatory mechanisms contribute to cell number regulation in acute renal failure. Acute tubular necrosis is the most frequent form of parenchymal acute renal failure. The main causes are ischemia-reperfusion, sepsis and nephrotoxic drugs. Exogenous factors such as nephrotoxic drugs and bacterial products, and endogenous factors such as lethal cytokines promote tubular cell apoptosis. Such diverse stimuli engage intracellular death pathways that in some cases are stimulus-specific. We now review the role of apoptosis in acute renal failure, the potential molecular targets of therapeutic intervention, the therapeutic weapons to modulate the activity of these targets and the few examples of therapeutic intervention on apoptosis.
Ortiz
Alberto
A
Nefrología, Fundación Jiménez Díaz, IRSIN y Universidad Autónoma de Madrid, Av Reyes Católicos 2, Madrid 28040, Spain. aortiz@fjd.es
Justo
Pilar
P
Sanz
Ana
A
Lorz
Corina
C
Egido
Jesús
J
D000208:Acute Disease; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D007684:Kidney Tubules / Q000293:injuries* / Q000473:pathology