title: Inclusion complexation and solubilization of paclitaxel by bridged bis(beta-cyclodextrin)s containing a tetraethylenepentaamino spacer.
abstract: A novel water-soluble paclitaxel complex has been prepared by inclusion complexation with bridged bis(beta-cyclodextrin)s and characterized by means of (1)H NMR, SEM, powder X-ray diffraction patterns, TG-DTA, DSC, FT-IR, and 2D NOESY. The cyclodextrins were able to solubilize paclitaxel to levels as high as 2 mg/mL. Furthermore, the cytotoxicity of the novel complexes was assessed using a K562 leukemia cell line which indicated that drug concentrations of 10 pg/mL elicited an inhibitory effect.
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China. yuliu@public.tpt.tj.cn
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Guo-Song
authors.initials: GS
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Heng-Yi
authors.initials: HY
authors.lastname: Zhang
authors.forename: Dong-Xu
authors.initials: DX
authors.lastname: Cao
authors.forename: Ying-Jin
authors.initials: YJ
authors.lastname: Yuan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D001952:Bridged-Ring Compounds / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D003505:Cyclodextrins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D008958:Models, Molecular; D017239:Paclitaxel / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D003505:Cyclodextrins; D011073:Polyamines; D017239:Paclitaxel