Improvements in the biokinetic model for strontium with allowance for age and gender differences in bone mineral metabolism.
An age- and gender-dependent biokinetic model for strontium was developed based on the study of a population living along the Techa River exposed to effluents from the Mayak Production Association (MPA). To estimate the parameters of a new model (Techa biokinetic model, TBM) many data sets have been assembled: our whole-body counter data on long-term retention of 90Sr in humans, data from studies during the period of global fallout, data resulting from deliberate injection of strontium radionuclides and non-radiological data regarding bone formation and resorption, mineral content of the body, etc. The model was developed using the basic structure of the ICRP biokinetic model for strontium, but new age- and gender-specific parameters were derived. This paper discusses the approaches applied to develop the new model.
Shagina
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NB
Urals Research Center for Radiation Medicine, Medgorodok, 454076, Chelyabinsk, Russia. nata@urcrm.chel.su
Tolstykh
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EI
Degteva
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MO
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001822:Body Burden; D001842:Bone and Bones / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D008954:Models, Biological; D011786:Quality Control; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods* / Q000592:standards; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012737:Sex Factors; D013324:Strontium / Q000032:analysis* / Q000493:pharmacokinetics*; D014875:Water Pollutants, Radioactive / Q000032:analysis / Q000493:pharmacokinetics*
D014875:Water Pollutants, Radioactive; D013324:Strontium