title: [Dyslipidemia and subclinical hypothyroidism].
abstract: BACKGROUND
  Subclinical hypothyroidism is defined as an increased serum TSH and normal serum FT4 concentration. In subclinical hypothyroidism, thyroid peroxidase and thyroglobulin antibodies are frequently present. Subclinical hypothyroidism may have endogenous or exogenous causes. The prevalence of subclinical hypothyroidism is rather high. The number of patients progressing to overt hypothyroidism may be higher. These patients may be asymptomatic, or have only mild symptoms or a single symptom.
  
  
  METHODS
  We investigated 35 patients with subclinical hypothyroidism in order to establish the type and degree of dyslipidemia and effects of therapy with L-thyroxine (50 micrograms/d) during three months.
  
  
  RESULTS
  Serum cholesterol, LDL-cholesterol and apo B were increased. A significant reduction of serum cholesterol, LDL-cholesterol and apo B concentrations was established during thyroid hormone replacement.
  
  
  CONCLUSIONS
  Only a few studies reported higher LDL and lower HDL-cholesterol values in subclinical hypothyroidism. Much interest was thus aroused to evaluate whether or not subclinical hypothyroidism is associated with hypercholesterolemia. Only patients with serum thyrotropin (TSH) concentration above 10 mU/L had a significant reduction of serum cholesterol concentration during thyroid hormone replacement. Most patients with subclinical hypothyroidism should be treated with thyroxine to prevent progression to overt hypothyroidism. Thyroid hormone replacement therapy may slow the progression of coronary heart disease, because of its beneficial effects on lipids. These findings and especially high rate of progression towards overt hypothyroidism suggest early thyroxine treatment.
authors.affiliation: Klinika za internu medicinu, KBC Dr Dragisa Misović, Dedinje, 11000 Beograd, Heroja Milana Tepića 1.
authors.forename: Zorica
authors.initials: Z
authors.lastname: Caparević
authors.forename: Gradimir
authors.initials: G
authors.lastname: Bojković
authors.forename: Dragos
authors.initials: D
authors.lastname: Stojanović
authors.forename: Vesna
authors.initials: V
authors.lastname: Ilić
mesh_terms: D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications*; D007037:Hypothyroidism / Q000097:blood / Q000150:complications*; D008297:Male; D008875:Middle Aged; D013974:Thyroxine / Q000097:blood
chemical_list: D013974:Thyroxine