title: [Clinical importance of the CagA and VacA proteins and of the host factores in the development of peptic ulcer in patients infected by Helicobacter pylori].
abstract: OBJECTIVE
  Demonstrate the role of the virulence factors of Helicobacter pylori, the sex, and tobacco and alcohol use in the development of peptic ulcer in patients infected by H. pylori.
  
  
  METHODS
  One hundred and seventy-four patient with dyspepsia were studied after they went consecutively for gastroscopy. The diagnosis of infection by H. pylori was carried out by culture and/or histology. Through western-blot the presence of specific anti-H. pylori antibodies was determined. The tobacco and alcohol use data were collected.
  
  
  RESULTS
  One hundred and twenty-five patients (32 with ulceration, 12 with duodenitis and 81 with functional dyspepsia) showed H. pylori infection with anti-bacterium IgG antibodies. The detection of the proteins CagA and VacA, male sex and heavy consumption of alcohol and tobacco were associated with the finding of peptic ulcer. In the multivariate analysis only anti-CagA antibodies (OR: 4.1; 95% CI: 1.1-15.3; p = 0.036), anti-VacA (OR: 3.9; 95% CI: 1.4-10.8; p = 0.009) and male sex (OR: 3.1; 95% CI: 1.2-8.3; p = 0.02) were associated with the ulcerative disease.
  
  
  CONCLUSIONS
  The proteins CagA and VacA, and the male sex, contribute independent risk factors for peptic ulcer in patients infected by H. pylori.
authors.affiliation: Servicio de Enfermedades Infecciosas. Hospital Carlos III. Madrid. Spain. carlostororueda@hotmail.com
authors.forename: C
authors.initials: C
authors.lastname: Toro Rueda
authors.forename: J
authors.initials: J
authors.lastname: García-Samaniego
authors.forename: I
authors.initials: I
authors.lastname: Casado Fariñas
authors.forename: M
authors.initials: M
authors.lastname: Rubio Alonso
authors.forename: M
authors.initials: M
authors.lastname: Baquero Mochales
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000453:epidemiology; D000942:Antigens, Bacterial / Q000235:genetics / Q000276:immunology*; D001426:Bacterial Proteins / Q000235:genetics / Q000276:immunology*; D005260:Female; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000175:diagnosis / Q000235:genetics / Q000382:microbiology*; D012907:Smoking / Q000453:epidemiology; D011795:Surveys and Questionnaires
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D007074:Immunoglobulin G; C074689:VacA protein, Helicobacter pylori; C080866:cagA protein, Helicobacter pylori