Deoxyribonolactone lesion in DNA: synthesis of fluorinated analogues.
Mono- and difluorinated derivatives of 2-deoxyribonolactone were synthesized using diastereoselective Reformatski reaction as a key step.
Crey
Caroline
C
LEDSS-UMR5616 associé au CNRS, BP53, Université Joseph Fourier, Grenoble, France.
Dumy
Pascal
P
Lhomme
Jean
J
Kotera
Mitsuharu
M
D004247:DNA / Q000737:chemistry*; D004249:DNA Damage; D003855:Deoxyribose / Q000031:analogs & derivatives*; D005461:Fluorine; D007783:Lactones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008957:Models, Genetic
D007783:Lactones; D005461:Fluorine; D003855:Deoxyribose; D004247:DNA