Benefits of different drug formulations in psychopharmacology.
Adequate dosage forms are essential for achieving successful pharmacotherapy. Innovative dosage forms or delivery systems may direct a drug to its specific site of action, optimize the timing of the drug release, or increase comfort or convenience for the patient. Thus, such innovations may improve efficacy and tolerability and lead to improvements in health-related quality of life. Specialized dosage forms (e.g., depot injections, extended-release formulations) of several psychiatric agents have been extensively used. The latest addition is an orally disintegrating formulation of the antidepressant mirtazapine. This dosage form dissolves rapidly in the mouth and is convenient for the large proportion of patients who have difficulty in swallowing tablets.
Frijlink
Henderik W
HW
Department of Pharmaceutical Technology and Biopharmacy, Groningen University Institute for Drug Exploration, Groningen, The Netherlands. frijlink@farm.rug.nl
D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002626:Chemistry, Pharmaceutical; D002940:Circadian Rhythm; D003550:Cystic Fibrosis / Q000188:drug therapy; D004333:Drug Administration Routes; D016503:Drug Delivery Systems; D006801:Humans; D008803:Mianserin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D000078785:Mirtazapine; D010349:Patient Compliance; D054328:Proton Pump Inhibitors; D017494:Proton Pumps / Q000008:administration & dosage; D011600:Psychopharmacology
D000900:Anti-Bacterial Agents; D054328:Proton Pump Inhibitors; D017494:Proton Pumps; D008803:Mianserin; D000078785:Mirtazapine