Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actions.
Chicken ovalbumin upstream promoter-transcription factors (COUP-TFs) are one of the most characterized orphan receptors of the steroid/thyroid hormone receptor superfamily. COUP-TFs play important roles in the regulation of organogenesis, neurogenesis, and cellular differentiation during embryonic development. COUP-TFs were generally considered to be repressors of transcription, however, there are growing evidences that COUP-TFs can function as transcription activators. Here we will review the molecular mechanism of COUP-TFs as repressors and activators. Also, we will review the known biological function of COUP-TFI during development and differentiation.
Park
Joo-In
JI
Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Tsai
Sophia Y
SY
Tsai
Ming-Jer
MJ
D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D051836:COUP Transcription Factors; D002454:Cell Differentiation; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D019281:Dimerization; D006801:Humans; D008957:Models, Genetic; D011987:Receptors, Steroid; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D051836:COUP Transcription Factors; D004268:DNA-Binding Proteins; D011987:Receptors, Steroid; D014157:Transcription Factors; D004247:DNA