title: Detection of anti-Borna Disease Virus (BDV) antibodies from patients with schizophrenia and mood disorders in Japan.
abstract: The relationship between infection with the Borna Disease Virus (BDV) and the clinical symptoms of schizophrenia and mood disorders (DMS-IV) was investigated. Western blotting techniques were used to examine anti-p10-BDV antibodies in serum from 32 patients with schizophrenia and 33 patients with mood disorders in Japan. The results showed that 1 out of 25 controls (4.0%), 7 out of 32 patients with schizophrenia (21.9%) and 9 out of 33 patients with mood disorders (27.3%) were positive for anti-BDV-p10 antibodies. Compared with levels of anti-BDV-p10 antibodies in controls, the production of anti-BDV-p10 antibodies failed to show a statistically significant relationship with schizophrenia but did show a significant relationship with mood disorder. The subgroup of schizophrenia patients with positive syndromes had a non-significantly higher frequency of anti-BDV-p10 antibodies than the subgroup of patients with negative syndromes. Similarly, the production of anti-BDV-p10 antibodies was non-significantly higher among patients with the unipolar subtype of mood disorder than in those with the bipolar subtype.
authors.affiliation: Department of Neurophysiology, Graduate School of Azabu University, 1-71-1 Futinobe, Sagamihara-shi, Kanagawa 229-8501, Japan.
authors.forename: Hayato
authors.initials: H
authors.lastname: Terayama
authors.forename: Yoshii
authors.initials: Y
authors.lastname: Nishino
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kishi
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Ikuta
authors.forename: Masahiro
authors.initials: M
authors.lastname: Itoh
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Iwahashi
mesh_terms: D000293:Adolescent; D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D015153:Blotting, Western; D001891:Borna disease virus / Q000276:immunology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000175:diagnosis / Q000276:immunology*; D012559:Schizophrenia / Q000175:diagnosis / Q000276:immunology*; D014764:Viral Proteins / Q000097:blood / Q000276:immunology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D014764:Viral Proteins; C077347:p40 protein, Borna disease virus