Pheophorbide A-methyl ester, Acyl-CoA: cholesterol acyltransferase inhibitor from Diospyros kaki.
In the course of our search for Acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from natural sources, a new type of ACAT inhibitor was isolated from a methanol extract of Diospyros kaki. On the basis of spectral and structural evidence, the compound was identified as pheophorbide A-methyl ester. Pheophorbide A-methyl ester inhibited ACAT activity in a dose dependent manner with an IC50 value of 1.85 microg/mL.
Rho
Mun-Chual
MC
Laboratory of Lipid Metabolism, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea.
Chung
Mi Yeon
MY
Song
Hye Young
HY
Kwon
Oh Eok
OE
Lee
Seung Woong
SW
Baek
Jin Ah
JA
Jeune
Kyung Hee
KH
Kim
Koanhoi
K
Lee
Hyun Sun
HS
Kim
Young Kook
YK
D000214:Acyl Coenzyme A / Q000737:chemistry* / Q000302:isolation & purification / Q000493:pharmacokinetics; D000818:Animals; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000302:isolation & purification / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D029788:Diospyros / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal; D008401:Gas Chromatography-Mass Spectrometry; D007723:Korea; D000432:Methanol; D008738:Methyl Ethers; D008862:Microsomes, Liver / Q000201:enzymology; D015394:Molecular Structure; D010936:Plant Extracts / Q000493:pharmacokinetics* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors* / Q000302:isolation & purification* / Q000493:pharmacokinetics
D000214:Acyl Coenzyme A; D004365:Drugs, Chinese Herbal; D008738:Methyl Ethers; D010936:Plant Extracts; D002734:Chlorophyll; D002785:Sterol O-Acyltransferase; C032623:pheophorbide a; D000432:Methanol