title: A novel PNA-monomer for recognition of thymine in triple-helix structures.
abstract: To expand the triplex recognition repertoire of Nucleic Acids, novel nucleobases that recognize thymine in a T-A base pair are still required. A novel conformationally constrained PNA-monomer (II) capable of binding T in a triplex motif was designed and synthesized in 7 steps starting from commercially available dimethyl 2-oxoglutarate.
authors.affiliation: Department of Chemistry, University of Copenhagen, Copenhagen O, Denmark. ago@kiku.edu
authors.forename: Anne Goldbech
authors.initials: AG
authors.lastname: Olsen
authors.forename: Otto
authors.initials: O
authors.lastname: Dahl
authors.forename: Peter E
authors.initials: PE
authors.lastname: Nielsen
mesh_terms: D020029:Base Pairing; D001665:Binding Sites; D009690:Nucleic Acid Conformation; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis*; D013941:Thymine
chemical_list: D020135:Peptide Nucleic Acids; D013941:Thymine