Spontaneous rupture of a first-trimester gravid uterus in a woman exposed to diethylstilbestrol in utero. A case report.
BACKGROUND
Poor reproductive outcome was well documented in several studies of women exposed to diethylstilbestrol in utero. Spontaneous rupture of an unscarred uterus is rare and very uncommon in the first trimester of pregnancy.


METHODS
Spontaneous rupture of the uterus was diagnosed in a 28-year-old nullipara who developed acute abdominal pain at 12 weeks' gestation. She was known to have been exposed to diethylstilbestrol in utero. Laparotomy revealed the rupture in the anterior fundal area of the uterus. Both tubes were normal.


CONCLUSIONS
Several spontaneous ruptures have been described, but this is the first case of first-trimester spontaneous rupture of an unscarred uterus in a diethylstilbestrol-exposed woman.
Porcu
Géraldine
G
Department of Obstetrics and Gynecology, Hôpitaux de Marseille, Marseille, France. geraldine.porcu@mail.ap-hm.fr
Courbière
Blandine
B
Sakr
Rita
R
Carcopino
Xavier
X
Gamerre
Marc
M
D000328:Adult; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011297:Prenatal Exposure Delayed Effects; D014597:Uterine Rupture / Q000209:etiology* / Q000601:surgery
D004054:Diethylstilbestrol