Medicine. PPARs as therapeutic targets: reverse cardiology?
Formation of the atherosclerotic lesions that lead to myocardial infarction is determined in part by inflammatory responses such as the production of lipid-laden macrophages. In his Perspective, Plutzky highlights the parts played by PPAR nuclear receptors, especially PPAR-delta (Lee et al.), in the modulation of inflammatory responses and hence atherosclerosis.
Plutzky
Jorge
J
Department of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. jplutzky@rics.bwh.harvard.edu
D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D016207:Cytokines / Q000235:genetics; D004268:DNA-Binding Proteins / Q000378:metabolism; D005487:Foam Cells / Q000502:physiology; D005786:Gene Expression Regulation; D007249:Inflammation / Q000209:etiology*; D008024:Ligands; D008071:Lipoprotein Lipase / Q000378:metabolism; D000071518:Liver X Receptors; D008264:Macrophages / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000378:metabolism; D051379:Mice; D057093:Orphan Nuclear Receptors; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051560:Proto-Oncogene Proteins c-bcl-6; D011956:Receptors, Cell Surface / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism*; D051193:Toll-Like Receptors; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D016207:Cytokines; D004268:DNA-Binding Proteins; D008024:Ligands; D000071518:Liver X Receptors; D008562:Membrane Glycoproteins; D057093:Orphan Nuclear Receptors; D011518:Proto-Oncogene Proteins; D051560:Proto-Oncogene Proteins c-bcl-6; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D051193:Toll-Like Receptors; D014157:Transcription Factors; D008071:Lipoprotein Lipase