title: Mathematical model of static platelet adhesion on a solid surface.
abstract: The scheme of platelet/surface interaction and a kinetic model of platelet adhesion on a solid surface are suggested. The elaborated approach takes into account the platelet activation by the surface and accumulation of free activated cells in the bulk of the liquid phase. This effect has an especially important role in static experimental conditions. The suggested model explains three types of adhesion kinetic curves, obtained in experiments in vitro: sigmoid curves with or without saturation and an exponential curve with saturation. According to the model, the curve shape is determined by material surface properties, platelet functionality, and experimental conditions of the platelet/surface interaction. The data of static platelet adhesion from platelet rich plasma on glass, siliconized glass, hexadecyltrichlorosilane monolayers, and low-density polyethylene are described mathematically with the proposed model. Numerical parameters are calculated from approximation of experimental data by the model. These parameters allow quantitative characterization of platelet interaction with the material surface.
authors.affiliation: Research Center for Biomaterials, Research Institute of Transplantology and Artificial Organs, 1 Shukinskaya, Moscow 123182, Russia.
authors.forename: Sergei L
authors.initials: SL
authors.lastname: Vasin
authors.forename: Igor A
authors.initials: IA
authors.lastname: Titushkin
authors.forename: Viktor I
authors.initials: VI
authors.lastname: Sevastianov
mesh_terms: D001672:Biocompatible Materials; D001792:Blood Platelets / Q000378:metabolism*; D002448:Cell Adhesion / Q000502:physiology*; D018929:Cell Culture Techniques; D003627:Data Interpretation, Statistical; D005898:Glass; D006801:Humans; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D012821:Silanes
chemical_list: D001672:Biocompatible Materials; D012821:Silanes; C111518:hexadecyltrichlorosilane