Is the target for thalamic deep brain stimulation the same as for thalamotomy?
Deep brain stimulation (DBS) has virtually replaced thalamotomy for the treatment of essential tremor. It is thought that the site for DBS is the same as the optimal lesion site; however, this match has not been investigated previously. We sought to determine whether the location of thalamic DBS matched the site at which thalamotomy would be performed. Eleven patients who had detailed microelectrode recording and stimulation for placement of DBS electrodes and subsequent successful tremor control were analysed. An experienced surgeon, blinded to outcome and final electrode position, selected the ideal thalamotomy site based on the reconstructed maps obtained intraoperatively. When the site of long-term clinically used DBS and theoretical thalamotomy location was calculated in three-dimensional space and compared for each of the x, y, and z axes in stereotactic space, there was no significant difference in the mediolateral location of DBS and theoretical lesion site. There was also no difference between the theoretical lesion site and the placement of the tip of the electrode; however, the active electrodes used for chronic stimulation were significantly more anterior (P = 0.005) and dorsal (P = 0.034) to the ideal thalamotomy target. This mismatch may reflect the compromise required between adverse and beneficial effects with chronic stimulation, but it also suggests different mechanisms of effect of DBS and thalamotomy.
Kiss
Zelma H T
ZH
Department of Clinical Neurosciences, University of Calgary, Foothills Hospital Calgary Health Region, Calgary, Alberta, Canada. zkiss@ucalgary.ca
Wilkinson
Marshall
M
Krcek
Jerry
J
Suchowersky
Oksana
O
Hu
Bin
B
Murphy
William F
WF
Hobson
Doug
D
Tasker
Ron R
RR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001931:Brain Mapping; D016022:Case-Control Studies; D004558:Electric Stimulation / Q000379:methods*; D004567:Electrodes, Implanted; D020329:Essential Tremor / Q000628:therapy*; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011597:Psychomotor Performance; D011612:Psychosurgery / Q000379:methods*; D013238:Stereotaxic Techniques; D013788:Thalamus / Q000033:anatomy & histology / Q000528:radiation effects* / Q000601:surgery*; D016896:Treatment Outcome