[Succivil efficacy in endogenous intoxication].
Succivil, a drug based on the blood substitute succinasol and containing 1,4-naphthoquinone, was studied as a means of restoring the living activity of cells occurring under extremal conditions of alcohol, heliotrin, or combined intoxication. A thorough investigation of the role of the free-radical oxidation in the dynamics of cell damage, in combination with histological, morphological, and biochemical data, showed that the aforementioned extremal intoxication factors lead to disorders in the cell energetics and intracell detoxicant system and to more or less manifested changes in the hemodynamic, biochemical, and physiological parameters. Succivil is capable of reanimating the cells damaged by the extremal factors studied.
Shevchenko
L I
LI
Laboratory of Biochemistry and Biotechnology, Institute of Hematology and Hemotransfusion, Usman Nasyr st. 138, Tashkent, 700170 Uzbekistan.
Khazbievich
I S
IS
Ageeva
G R
GR
D000818:Animals; D001547:Benzaldehydes / Q000506:poisoning; D052117:Benzodioxoles; D001802:Blood Substitutes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000431:Ethanol / Q000506:poisoning; D005609:Free Radicals / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D010084:Oxidation-Reduction; D011041:Poisoning / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011817:Rabbits
D001547:Benzaldehydes; D052117:Benzodioxoles; D001802:Blood Substitutes; D005609:Free Radicals; D009285:Naphthoquinones; D000431:Ethanol; C005454:piperonal; C035342:1,4-naphthoquinone