Synthesis of 5-azacytidine nucleosides with rigid sugar moiety as potential antitumor agents.
The bicyclic 3'-O,5'-C-methylene-linked and 2'-O,5'-C-methylene-linked 5-azacytidine derivatives were readily synthesized from 1,2;5,6-di-O-isopropylidene-D-glucose and evaluated against several cancer cell lines.
Chun
Moon Woo
MW
College of Pharmacy, Seoul National University, Seoul, Korea. mwchun@snu.ac.kr
Kim
Myong Jung
MJ
Kim
Hea Ok
HO
Kim
Hee-Doo
HD
Kim
Joong Hyup
JH
Moon
Hyung Ryong
HR
Jeong
Lak Shin
LS
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001374:Azacitidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D001374:Azacitidine