title: Biphasic modulation of cell proliferation by quercetin at concentrations physiologically relevant in humans.
abstract: Optimal in vitro conditions regarding quercetin solubility and stability were defined. Using these conditions, the effect of quercetin on proliferation of the colon carcinoma cell lines HCT-116 and HT29 and the mammary adenocarcinoma cell line MCF-7 was investigated. For the colon carcinoma cell lines, at relatively high concentrations, a significant decrease in cell proliferation was observed, providing a basis for claims on the anti-carcinogenic activity of quercetin. However, at lower concentrations, a subtle but significant stimulation of cell proliferation was observed for all cell lines tested. These results point at a dualistic influence of quercetin on cell proliferation that may affect present views on its supposed beneficial anti-proliferative effect.
authors.affiliation: Division of Toxicology, Wageningen University, 6703 HE, Wageningen, The Netherlands. hester.vanderwoude@wur.nl
authors.forename: Hester
authors.initials: H
authors.lastname: van der Woude
authors.forename: Anna
authors.initials: A
authors.lastname: Gliszczyńska-Swigło
authors.forename: Karin
authors.initials: K
authors.lastname: Struijs
authors.forename: Astrid
authors.initials: A
authors.lastname: Smeets
authors.forename: Gerrit M
authors.initials: GM
authors.lastname: Alink
authors.forename: Ivonne M C M
authors.initials: IM
authors.lastname: Rietjens
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms / Q000473:pathology*; D019073:HT29 Cells; D006801:Humans; D011794:Quercetin / Q000737:chemistry / Q000494:pharmacology*; D012995:Solubility; D014407:Tumor Cells, Cultured
chemical_list: D011794:Quercetin