Computer simulation for effect of Pr(III) on Ca(II) speciation in human interstitial fluid.
A multiphase model of metal ion speciation in human interstitial fluid was constructed and the effect of Pr(III) on Ca(II) speciation was studied. Results show that free Ca2+, [Ca(HCO3)], and [Ca(Lac)] are the main species of Ca(II). Because of the competition of Pr(III) for ligands with Ca(II), the percentages of free Ca2+, [Ca(Lac)], and [Ca(His)(Thr)H3] increase gradually and the percentages of CaHPO4(aq) and [Ca(Cit)(His)H2] decrease gradually with the increase in the total concentration of Pr(III). However, the percentages of [Ca(HCO3)] and CaCO3(aq) first increase and then begin to decrease when the total concentration of Pr(III) exceeds 6.070 x 10-4 M.
Zhang
Haiyuan
H
Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
Lu
Xing
X
Wang
Jinping
J
Yang
Kuiyue
K
Niu
Chunji
C
Ni
Jiazuan
J
D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D003198:Computer Simulation; D045604:Extracellular Fluid / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D008670:Metals / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008954:Models, Biological; D008956:Models, Chemical; D011221:Praseodymium / Q000378:metabolism* / Q000494:pharmacology
D008024:Ligands; D008670:Metals; D011221:Praseodymium; D002118:Calcium