Beta2-microglobulin clearance with super high flux hemodialysis: an ex vivo study.
BACKGROUND
Beta2m accumulation induces disease in patients with end-stage renal failure (ESRF). Thus, its removal from patients with ESRF appears desirable. Current dialysis technology, however, has limited effectiveness.


OBJECTIVE
To measure beta2m clearance with a novel super high flux membrane.


METHODS
Ex vivo experimental study.


METHODS
Intensive Care Laboratory of Tertiary institution.


METHODS
Six volunteers.


RESULTS
At a blood flow of 300 ml/min, the clearance of beta2-MG increased from 113.5 +/- 38.5 ml/min with a dialysate flow rate of 200 ml/min to 184.8 +/- 61.1 ml/min with a flow rate of 300 ml/min and 195.0 +/- 60.0 ml/min with a 500 ml/min flow rate. The clearance of albumin was 4.5 ml/min with a dialysate flow rate of 200 ml/min, 5.2 ml/min for a flow rate of 300 ml/min and 5.8 ml/min for a flow rate of 500 ml/min.


CONCLUSIONS
High levels of beta2m clearance can be achieved with a super high flux membrane while albumin losses remain limited.
Lee
W C R
WC
Department of Intensive Care, Austin & Repatriation Medical Centre, Melbourne, Australia.
Uchino
S
S
Fealy
N
N
Baldwin
I
I
Panagiotopoulos
S
S
Goehl
H
H
Morgera
S
S
Neumayer
H H
HH
Bellomo
R
R
D016001:Confidence Intervals; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008567:Membranes, Artificial; D006435:Renal Dialysis / Q000379:methods*; D001613:beta 2-Microglobulin / Q000097:blood*
D008567:Membranes, Artificial; D001613:beta 2-Microglobulin