Effect of rotenoids from the seeds of Millettia dura on larvae of Aedes aegypti.
A crude chloroform extract of seeds of Millettia dura Dunn (Leguminosae) showed high activity (LC50 = 3.5 microg ml(-1) at 24 h) against second-instar larvae of the mosquito, Aedes aegypti L (Diptera: Culicidae). The rotenoids, deguelin and tephrosin, isolated from the seeds of this plant also showed potent activities, with LC50 values of 1.6 and 1.4 microg ml(-1) at 24 h, respectively. The related rotenoids millettone and millettosin were inactive at 20 microg ml(-1). Saturation at the B/C ring junction and the presence of methoxy groups at C-2 and/or C-3 in deguelin and tephrosin appear to be important for the observed larvicidal activity.
Yenesew
Abiy
A
Department of Chemistry, University of Nairobi, PO Box 30197, Nairobi, Kenya. ayenesew@uonbi.ac.ke
Derese
Solomon
S
Midiwo
Jacob O
JO
Heydenreich
Matthias
M
Peter
Martin G
MG
D000330:Aedes / Q000187:drug effects*; D000818:Animals; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D007814:Larva / Q000187:drug effects; D033641:Millettia / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D012402:Rotenone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D012639:Seeds / Q000737:chemistry*
D002867:Chromones; D007306:Insecticides; D010936:Plant Extracts; D011714:Pyrans; C480850:millettosin; D012402:Rotenone; C480849:millettone; C480848:tephrosin; C107676:deguelin