[Structural-dynamic analysis of the mechanism of clinical response and treatment prognosis].
The paper presents the results of testing of a new approach to study the inter-syndrome links in initial and follow up status of patients treated with atypical antipsychotics and to determine a system of prognostic clinical factors. The method, named structural-dynamic analysis, is based on comparison of initial and final structure of patient's condition grouped by the features of dynamics of its separate elements. These elements are chosen in accordance to PANSS and the grouping, therefore, is performed 30 times. The subject of the study was a sample of 89 patients with acute exacerbation of schizophrenia with intermittent course treated with atypical antipsychotic as monotherapy. The results of the study demonstrated that the new approach was informative and allowed to elucidate the most important parts of patient's condition, changes of which served as a basis for alterations in many other aspects of clinical status and consequently could be determined as the main characteristics of treatment efficacy. At the same time, these parts not in all the cases define the features of the clinical picture, being overlapped by the more striking symptoms. However, changes of the latter much less reflect the global changes in biological processes influenced by antipsychotics.
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D000208:Acute Disease; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D012563:Schizophrenia, Paranoid / Q000175:diagnosis* / Q000523:psychology / Q000628:therapy*; D012720:Severity of Illness Index