Design, synthesis, and in vitro evaluation of APIO analogue of neplanocin A.
A novel apio analogue of neplanocin A was efficiently synthesized from D-ribose via stereoselective aldol-retroaldol reaction for introducing hydroxymethyl group and RCM reaction for synthesizing carbocycle, and its inhibitory activity against SAH hydrolase was assayed.
Moon
Hyung Ryong
HR
College of Pharmacy, Ewha Womans University, Seoul, South Korea.
Kwon
Sung Hee
SH
Lee
Jeong Ah
JA
Yoo
Byul Nae
BN
Kim
Hea Ok
HO
Chun
Moon Woo
MW
Kim
Hee-Doo
HD
Kim
Joong Hyup
JH
Jeong
Lak Shin
LS
D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D043383:Adenosylhomocysteinase / Q000037:antagonists & inhibitors*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; C031096:neplanocin A; D043383:Adenosylhomocysteinase; D000241:Adenosine