title: Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD.
abstract: Mutations in DJ-1 are a cause of autosomal recessive parkinsonism. Polymorphism of genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). The authors analyzed whether a polymorphism (g.168_185del) within exon 1 of DJ-1 contributes to the risk of sporadic PD in a Finnish case-control series. This gene does not play a major role in the genetic predisposition to PD in this population.
authors.affiliation: Department of Neurology, Helsinki University Central Hospital and University of Helsinki, Biomedicum-Helsinki, Neuroscience Programme, Finland.
authors.forename: J
authors.initials: J
authors.lastname: Eerola
authors.forename: D
authors.initials: D
authors.lastname: Hernandez
authors.forename: J
authors.initials: J
authors.lastname: Launes
authors.forename: O
authors.initials: O
authors.lastname: Hellström
authors.forename: S
authors.initials: S
authors.lastname: Hague
authors.forename: C
authors.initials: C
authors.lastname: Gulick
authors.forename: J
authors.initials: J
authors.lastname: Johnson
authors.forename: T
authors.initials: T
authors.lastname: Peuralinna
authors.forename: J
authors.initials: J
authors.lastname: Hardy
authors.forename: P J
authors.initials: PJ
authors.lastname: Tienari
authors.forename: A B
authors.initials: AB
authors.lastname: Singleton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D004252:DNA Mutational Analysis; D005260:Female; D005387:Finland / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D015513:Oncogene Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D000071617:Protein Deglycase DJ-1; D018570:Risk Assessment
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D015513:Oncogene Proteins; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1