title: [Changes of oxygen cost of breathing in children and adult during anesthesia and surgery].
abstract: OBJECTIVE
  To investigate the changes of oxygen cost of breathing (OCB) in children and adult during general anesthesia and surgery.
  
  
  METHODS
  This study included 12 elective surgical children and 12 adult patients receiving cerebral surgery. Mechanical ventilation was given during general anesthesia and surgery, and the indices of hemodynamics and respiratory function were measured at 5 min before induction, 1 min before the start of surgery, 30, 60, 120 and 180 min after the start of surgery and at the end of surgery, respectively.
  
  
  RESULTS
  Mean arterial pressure (MAP) in the 2 groups did not undergo any conspicuous changes during general anesthesia and surgery (P>0.05), and the heart rate in child group was markedly faster than that in adult group during the whole course (P<0.01). Oxygen consumption (VO2) in 2 groups at 1 min before the start of surgery and 30 min after the start of surgery was significantly higher than that at 5 min before induction (P<0.01), and at these two time points after induction, child group had much higher VO2 (P<0.05) but evidently lower OCB (P<0.01) than in adult group, the latter index remained low till 60 and 120 min after the start of surgery (P<0.05).
  
  
  CONCLUSIONS
  During anesthesia and surgery, VO2 in child group can be much greater than that in Adult group, while OCB markedly lower.
authors.affiliation: Department of Anesthesiology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
authors.forename: Shi-wei
authors.initials: SW
authors.lastname: Liang
authors.forename: Jin-fang
authors.initials: JF
authors.lastname: Xiao
authors.forename: Ji-wu
authors.initials: JW
authors.lastname: Yang
authors.forename: Ye-ming
authors.initials: YM
authors.lastname: Chen
authors.forename: Chun-shui
authors.initials: CS
authors.lastname: Lin
authors.forename: Miao-ning
authors.initials: MN
authors.lastname: Gu
mesh_terms: D000328:Adult; D000768:Anesthesia, General; D001794:Blood Pressure; D001921:Brain / Q000601:surgery*; D002648:Child; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D012119:Respiration