[Risk factors for intracerebral hemorrhage after intravenous thrombolysis in acute cerebral infarction].
OBJECTIVE
To identify risk factors of intracerebral hemorrhage (ICH) after intravenous thrombolysis in acute cerebral infarction.


METHODS
Eighty-two patients with acute cerebral infarction were treated with intravenous urokinase within 12 hours from stroke onset. The data of clinic and laboratory were as readily available baseline factors and were analyzed to select potential contributors to ICH.


RESULTS
ICH occurred in 15 patients (18.3%), including 6 hemorrhagic infarction (HI, 7.3%) and 9 Parenchyma hemorrhage (PH, 11.0%). Seven patients had symptomatic ICH, and 4 patients died. Patients with ICH had significantly lower European stroke scale (ESS) scores. Patients with ESS<60 scores, early ischemic changes (EIC) on cranial CT scans or artrial fibrillation had significantly higher risk of ICH.


CONCLUSIONS
Risk factors associated with ICH are severity of neurological deficit, EIC and artrial fibrillation.
Li
Dou
D
Complex Internal Medicine, Beijing Emergency Central, Beijing 100031, China.
Lei
Yan-ni
YN
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000209:etiology*; D002544:Cerebral Infarction / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed; D014568:Urokinase-Type Plasminogen Activator / Q000009:adverse effects*
D014568:Urokinase-Type Plasminogen Activator