Synthesis and antiviral evaluation of 2',3'-dideoxy-2'-fluoro-3'- C-hydroxymethyl-beta-D-arabinofuranosyl pyrimidine nucleosides.
The synthesis and anti-HBV and anti-HIV activity of a number of 2',3'-dideoxy-2'-fluoro-3'-C-hydroxymethyl-beta-D-arabinofuranosyl pyrimidine nucleosides are reported.
Hassan
Abdalla E A
AE
Pharmasset Inc., Tucker, Georgia 30084, USA. ahassan@services.pharmasset.com
Pai
Balakrina S
BS
Lostia
Stefania
S
Stuyver
Lieven
L
Otto
Michael J
MJ
Schinazi
Raymond F
RF
Watanabe
Kyoichi A
KA
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006678:HIV / Q000187:drug effects; D006515:Hepatitis B virus / Q000187:drug effects; D007202:Indicators and Reagents; D008968:Molecular Conformation; D015394:Molecular Structure; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000998:Antiviral Agents; D007202:Indicators and Reagents; D011741:Pyrimidine Nucleosides