title: Parenteral nutrition-associated cholestasis in neonates: the role of aluminum.
abstract: Parenteral nutrition (PN) is an essential component in the care of premature and ill infants. The incidence of parenteral nutrition-associated cholestasis (PNAC) ranges from 7.4 to 84%. One substance in PN solutions that has been implicated in PNAC is aluminum. Aluminum loading in animals and humans causes hepatic accumulation and damage. The degree of aluminum contamination of PN solutions has decreased over time, but contamination still significantly exceeds levels that are safe for human neonates. Further study into the relationship between aluminum contamination in neonatal PN solutions and the development of PNAC is necessary.
authors.affiliation: College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7M 0Z9.
authors.forename: Chris J
authors.initials: CJ
authors.lastname: Arnold
authors.forename: Grant G
authors.initials: GG
authors.lastname: Miller
authors.forename: Gordon A
authors.initials: GA
authors.lastname: Zello
mesh_terms: D000535:Aluminum / Q000009:adverse effects*; D002779:Cholestasis / Q000453:epidemiology / Q000209:etiology*; D005506:Food Contamination; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D010288:Parenteral Nutrition / Q000009:adverse effects*
chemical_list: D000535:Aluminum