[Effectiveness evaluation and prognostic factor analysis in patients with minor salivary gland carcinoma of the hard palate].
OBJECTIVE
Minor salivary gland carcinoma of the hard palate is rare, and its long-term survival rate is high, making it difficult to evaluate the prognostic factors and the efficacy of treatment. This study was designed to evaluate the efficacy of treatment and investigate the prognostic factors of minor salivary gland carcinoma of the hard palate.


METHODS
Ninety-six cases of minor salivary gland carcinoma of the hard palate hospitalized in Cancer Center, Sun Yat-sen University, from 1964 to 2001 were reviewed retrospectively. The cumulative survival rate was analyzed by Kaplan-Meier method. The factors were compared using the log-rank test. The influencing factors were screened by Cox proportional hazards model.


RESULTS
The 5- and 10-year overall survival rates were 65.60% and 47.90%, respectively. The 5- and 10-year disease-specific survival rates for the patients treated with surgery (53 cases) and surgery + radiotherapy (35 cases) were 73.14%, 67.40% and 66.58%,46.60%,respectively. Multivariate analysis showed that age >or=50 years old,tumor size >or=3 cm,surgical margin status,and recurrence were independently associated with decreased survival rates (P< 0.05).


CONCLUSIONS
Surgery or surgery dominated multi-modality therapy was the principal treatment modality for minor salivary gland carcinoma of the hard palate. Age >or=50 years old, tumor size >or=3 cm, surgical margin status, and recurrence are independent factors affecting the prognosis.
Liu
Xue-Kui
XK
Department of Head and Neck Surgery, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, PR China.
Zeng
Zong-Yuan
ZY
Chen
Fu-Jin
FJ
Guo
Zhu-Ming
ZM
Xu
Guang-Pu
GP
Yang
An-Kui
AK
Zhang
Quan
Q
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010157:Palatal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D021362:Palate, Hard; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D012470:Salivary Glands, Minor