title: Phosphodiesterase 4 inhibitors: antiinflammatory therapy for chronic obstructive pulmonary disease at last?
authors.forename: Huib A M
authors.initials: HA
authors.lastname: Kerstjens
authors.forename: Wim
authors.initials: W
authors.lastname: Timens
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000893:Anti-Inflammatory Agents / Q000276:immunology / Q000627:therapeutic use*; D001993:Bronchodilator Agents / Q000276:immunology / Q000627:therapeutic use*; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D002264:Carboxylic Acids; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D003509:Cyclohexanecarboxylic Acids; D006801:Humans; D007249:Inflammation; D007958:Leukocyte Count; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D009570:Nitriles; D010726:Phosphodiesterase Inhibitors / Q000276:immunology / Q000627:therapeutic use*; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D001993:Bronchodilator Agents; D002264:Carboxylic Acids; D003509:Cyclohexanecarboxylic Acids; D009570:Nitriles; D010726:Phosphodiesterase Inhibitors; C433247:Cilomilast; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4