[HPA-5b neonatal allo-immune thrombocytopenia: two cases described in Tunisia].
Alloimmune thrombocytopenia is due to feto-maternal incompatibility in the HPA systems and is usually considered in the diagnosis of neonatal thrombocytopenia after other causes have been excluded. We report on two Tunisian observations of alloimmune neonatal thrombocytopenia due to anti-HPA-5b (Bra) antibodies.


METHODS
Two neonates presented at birth with a thrombocytopenic purpura unexplained by usual causes of neonatal thrombocytopenia. Alloimmune neonatal thrombocytopenia was diagnosed by the determination of parental and neonatal platelets antigens phenotypes and by the presence of HPA-5b (antiBra) antibodies in maternal sera. A favourable evolution was obtained after maternal platelet transfusions.


CONCLUSIONS
Alloimmune neonatal thrombocytopenia is a serious affection, which exposes to intracranial haemorrhage. These observations of HPA-5 neonatal alloimmunisation in Tunisia provide additional information on the geographic distribution of the disease and its prognosis.
Skouri
H
H
Laboratoire d'hématologie et banque du sang, CHU Sahloul, 4000 Sousse, Tunisie. hadef.skouri@rns.tn
Soua
H
H
Seket
B
B
Elomri
H
H
Mounastiri
K
K
Ayadi
A
A
Gueddiche
M N
MN
Sfar
M T
MT
Bierling
P
P
D016824:Antigens, Human Platelet / Q000276:immunology*; D002543:Cerebral Hemorrhage / Q000209:etiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011379:Prognosis; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000276:immunology* / Q000473:pathology; D012307:Risk Factors; D014416:Tunisia
C055973:5b alloantigen, human; D016824:Antigens, Human Platelet