title: Constituents of the Argentinian medicinal plant Baccharis grisebachii and their antimicrobial activity.
abstract: The resinous exudate of Baccharis grisebachii which is used to treat ulcers, burns, and skin sores in Argentina showed activity towards dermatophytes and bacteria. Two diterpenes, eight p-coumaric acid derivatives, and two flavones were isolated from the exudate and the structures elucidated by spectroscopic methods. 3-Prenyl-p-coumaric acid and 3,5-diprenyl-p-coumaric acid were active towards Epidermophyton floccosum and Trichophyton rubrum with MICs of 50 and 100-125 microg/ml, respectively. The diterpene labda-7,13E-dien-2beta,15-diol was active towards Epidermophyton floccosum and Trichophyton rubrum with MICs of 12.5 microg/ml while the MIC against Microsporum canis and Trichophyton mentagrophytes was 25 microg/ml. The diterpene was also active towards Microsporum gypseum with a MIC of 50 microg/ml, and showed inhibition in both Staphylococcus aureus (methicilline resistant and sensible strains) with MICs of 125 microg/ml. The results support the use of Baccharis grisebachii in Argentinian traditional medicine.
authors.affiliation: Instituto de Ciencias Básicas, Universidad Nacional de San Juan, Av. José Ignacio de La Roza 230 (O), C.P. 5400, San Juan, Argentina.
authors.forename: Gabriela Egly
authors.initials: GE
authors.lastname: Feresin
authors.forename: Alejandro
authors.initials: A
authors.lastname: Tapia
authors.forename: Antonio
authors.initials: A
authors.lastname: Gimenez
authors.forename: Angel Gutierrez
authors.initials: AG
authors.lastname: Ravelo
authors.forename: Susana
authors.initials: S
authors.lastname: Zacchino
authors.forename: Maximiliano
authors.initials: M
authors.lastname: Sortino
authors.forename: Guillermo
authors.initials: G
authors.lastname: Schmeda-Hirschmann
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001118:Argentina; D031175:Baccharis; D001419:Bacteria / Q000187:drug effects; D003373:Coumaric Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000493:pharmacokinetics; D005658:Fungi / Q000187:drug effects; D008519:Medicine, Traditional; D035261:Plant Components, Aerial; D012116:Resins, Plant / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003373:Coumaric Acids; D004224:Diterpenes; D005419:Flavonoids; D012116:Resins, Plant