New insights into the possible role of bacteriophages in transplantation.
Due to the increasing prevalence of drug-resistant bacterial infections in the "post-antibiotic era," bacteriophages (bacterial viruses, BP) may be useful to administer to transplant recipients without exposing them to an increased risk of rejection, which occurs consequent to some viral infections. Herein we present evidence that at least some coliphages (T4) do not pose such risk. Interestingly, they may produce immunosuppressive effects extending transplant survival. Our data suggest that BP may be used in clinical transplantation to treat drug-resistant bacterial infections and perhaps as an adjunct to immunosuppressive therapy.
Gorski
A
A
Department of Clinical Immunology, Transplantation Institute, The Medical University of Warsaw, Poland.
Nowaczyk
M
M
Weber-Dabrowska
B
B
Kniotek
M
M
Boratynski
J
J
Ahmed
A
A
Dabrowska
K
K
Wierzbicki
P
P
Switala-Jelen
K
K
Opolski
A
A
D000818:Animals; D001435:Bacteriophages / Q000276:immunology*; D003090:Coliphages / Q000276:immunology*; D006084:Graft Rejection / Q000517:prevention & control*; D007165:Immunosuppression Therapy / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D016038:Skin Transplantation / Q000276:immunology*; D014184:Transplantation, Homologous / Q000276:immunology