ESCRS Binkhorst lecture 2002: Pseudophakic preservative maculopathy.
Many antiglaucoma eyedrops are reported to cause cystoid macular edema (CME) in aphakia and pseudophakia. We review 4 clinical and laboratory studies that compare the incidence of CME in early postoperative pseudophakia in eyes that received preserved latanoprost and timolol, nonpreserved timolol, and the preserved and nonpreserved vehicle for these drugs and looked at the morphological damage to cells and the changes in the indicators of cytokine and prostaglandin (PG) synthesis caused by latanoprost and timolol and the preservative benzalkonium chloride. Based on the findings of these studies, which indicate that the preservative causes increased synthesis of PGs and other substances and intensified postoperative inflammation, the term pseudophakic preservative maculopathy is proposed for CME caused by antiglaucoma eyedrops.
Miyake
Kensaku
K
Shohzankai Medical Foundation, Miyake Eye Hospital, Nagoya, Japan. miyake@spice.or.jp
Ibaraki
Nobuhiro
N
Goto
Yoko
Y
Oogiya
Shin
S
Ishigaki
Junko
J
Ota
Ichiro
I
Miyake
Sampei
S
D001082:Aqueous Humor / Q000187:drug effects; D002387:Cataract Extraction / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D007249:Inflammation / Q000209:etiology; D007429:Intraocular Pressure / Q000187:drug effects; D000077338:Latanoprost; D008269:Macular Edema / Q000139:chemically induced / Q000453:epidemiology / Q000209:etiology*; D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage; D019591:Pseudophakia / Q000150:complications*; D013999:Timolol / Q000008:administration & dosage
D009883:Ophthalmic Solutions; D011310:Preservatives, Pharmaceutical; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost; D013999:Timolol