Immunological reconstitution in long-term survivors of thalassemia major patients after hematopoietic stem cell transplantation.
We studied the immune function of 33 long-term survivors of thalassemia after hematopoietic stem cell transplantation. Lymphocyte subsets, lymphoproliferative response and immunoglobulin were normal but the level of natural killer cells was low. Five and seven patients had suboptimal antibody response at 4 week after pneumococcal and hepatitis B vaccine, respectively, but this response returned to normal by 6 months.
Li
Chi Kong
CK
Leung
Ting Fan
TF
Chan
Paul K S
PK
Chick
Ki Wai
KW
Lee
Vincent
V
Cheung
Albert Y K
AY
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006410:Hematopoiesis / Q000502:physiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D008297:Male; D017741:Survivors; D017086:beta-Thalassemia / Q000601:surgery*