Asymmetric sulfur ylide mediated aziridination: application in the synthesis of the side chain of taxol.
[reaction: see text] Sulfur ylide methodology has been used to construct the Taxol side chain with a high degree of enantioselectivity via a trans-aziridine followed by stereospecific rearrangement of the trans-benzoylaziridine into a trans-oxazoline.
Aggarwal
Varinder K
VK
School of Chemistry, Cantock's Close, University of Bristol, Bristol BS8 1TS, UK. v.aggarwal@bristol.ac.uk
Vasse
Jean-Luc
JL
D001388:Aziridines / Q000737:chemistry*; D008956:Models, Chemical; D017239:Paclitaxel / Q000138:chemical synthesis*; D013457:Sulfur Compounds / Q000737:chemistry*
D001388:Aziridines; D013457:Sulfur Compounds; D017239:Paclitaxel