Stereocontrolled synthesis of diene and enyne sugar-modified nucleosides and their interaction with S-adenosyl-L-homocysteine hydrolase.
Conjugated diene 5-7 and enyne 8 analogs derived from adenosine and uridine were synthesized employing Pd-catalyzed cross-coupling reactions.
Wnuk
Stanislaw F
SF
Department of Chemistry, Florida International University, Miami, Florida 33199, USA. wnuk@fiu.edu
Sacasa
Pablo R
PR
Crain
Leigh N
LN
Lewandowska
Elzbieta
E
Zhang
Jinsong
J
Borchardt
Ronald T
RT
D043383:Adenosylhomocysteinase / Q000378:metabolism*; D007202:Indicators and Reagents; D007700:Kinetics; D009243:NAD / Q000378:metabolism; D009705:Nucleosides / Q000138:chemical synthesis* / Q000378:metabolism*; D013379:Substrate Specificity
D007202:Indicators and Reagents; D009705:Nucleosides; D009243:NAD; D043383:Adenosylhomocysteinase