title: [Mechanism of quercetin as an antidiarrheal agent].
abstract: OBJECTIVE
  To investigate the antidiarrheal mechanism of quercetin extracted from Psidium guajava L.
  
  
  METHODS
  The effects of quercetin on the contractility of guinea pig ileum in vitro and on the peristaltic motion of mouse small intestine in vivo were observed, and the peak value of contractility and peristaltic distance recorded. The inhibitory effect of quercetin on the permeability of the abdominal capillaries was also observed.
  
  
  RESULTS
  Quercetin inhibited the contraction of guinea pig ileum in vitro and the peristaltic motion of mouse small intestine, and reduced the permeability of abdominal capillaries.
  
  
  CONCLUSIONS
  Quercetin can inhibit the intestinal movement and reduce capillary permeability in the abdominal cavity, which may be the antidiarrheal mechanism of Psidium guajava L extract.
authors.affiliation: Department of Traditional Chinese Medicine, First Military Medical University, Guangzhou 510515, China. zhangwj91@sohu.com
authors.forename: Wen-ju
authors.initials: WJ
authors.lastname: Zhang
authors.forename: Bao-tian
authors.initials: BT
authors.lastname: Chen
authors.forename: Cai-yun
authors.initials: CY
authors.lastname: Wang
authors.forename: Quan-hong
authors.initials: QH
authors.lastname: Zhu
authors.forename: Zhi-xian
authors.initials: ZX
authors.lastname: Mo
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000494:pharmacology*; D001285:Atropine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D011794:Quercetin / Q000494:pharmacology*
chemical_list: D000930:Antidiarrheals; D001285:Atropine; D011794:Quercetin