title: [Diagnosis and treatment of primary germ cell tumors of the mediastinum. Report of six cases].
abstract: Primary germ cell tumours of the mediastinum are rare. We report a retrospective study of six cases. Sex ratio was 2/1. The tumor site was the posterior mediastinum in two patients and anterior in the remaining cases. High level serum markers was noted in two patients. At histologic exam we found two cases of seminoma, one embryonal carcinoma, one case of yolk sac tumor and two cases of composite tumor. All patients had non metastatic but locally advanced disease at diagnosis. Three patients were treated with cisplatin based chemotherapy followed by radiotherapy or surgical resection of residual masses. Only one patient is still alive. As it is often reported in the literature, the prognosis of this disease is poor especially for non seminomatous tumours.
authors.affiliation: Service Médecine Carcinologique, Hôpital Farhat Hached Sousse.
authors.forename: Amel
authors.initials: A
authors.lastname: Landolsi
authors.forename: Hasna
authors.initials: H
authors.lastname: Tarmiz
authors.forename: Leila
authors.initials: L
authors.lastname: Ben Fatma
authors.forename: Lamia
authors.initials: L
authors.lastname: Kallel
authors.forename: Olfa
authors.initials: O
authors.lastname: Gharbi
authors.forename: Chakib
authors.initials: C
authors.lastname: Kraïem
authors.forename: Sadok
authors.initials: S
authors.lastname: Korbi
authors.forename: Slim
authors.initials: S
authors.lastname: Ben Ahmed
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D018237:Germinoma / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D008875:Middle Aged; D012189:Retrospective Studies