title: Anemia and hepatosplenomegaly as presenting features in a child with rickets and secondary myelofibrosis.
abstract: Anemia and hepatosplenomegaly are common reasons for referring a child to a pediatric hematologist or oncologist. Among the many causes for these findings is severe rickets, which has been shown to be associated with secondary myelofibrosis and myeloid metaplasia. The authors present the case of an infant with severe rickets and secondary myelofibrosis and review the differential diagnosis of hepatosplenomegaly from the viewpoint of the pediatric hematologist/oncologist.
authors.affiliation: Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA.
authors.forename: Barbara A
authors.initials: BA
authors.lastname: Gruner
authors.forename: Thomas S
authors.initials: TS
authors.lastname: DeNapoli
authors.forename: Said
authors.initials: S
authors.lastname: Elshihabi
authors.forename: Howard A
authors.initials: HA
authors.lastname: Britton
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Langevin
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Thomas
authors.forename: Steven D
authors.initials: SD
authors.lastname: Weitman
mesh_terms: D000740:Anemia / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D002117:Calcitriol / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006529:Hepatomegaly / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D055728:Primary Myelofibrosis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D012279:Rickets / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D013163:Splenomegaly / Q000150:complications* / Q000175:diagnosis / Q000473:pathology
chemical_list: D002117:Calcitriol