Molecular recognition of quadruplex DNA by quinacridine derivatives.
The interaction of monomeric and dimeric quinacridines with quadruplex DNA has been investigated using a variety of biophysical methods. Both series of compounds were shown to exhibit a high affinity for the G4 conformation with two equivalent binding sites. As shown from the SPR and dialysis experiments the macrocyclic dimer appears more selective than its monomeric counterpart.
Teulade-Fichou
M P
MP
LCIM, Collège de France, Paris, France. mp.teulade-fichou@college-de-france.fr
Hounsou
C
C
Guittat
L
L
Mergny
J L
JL
Alberti
P
P
Carrasco
C
C
Bailly
C
C
Lehn
J M
JM
Wilson
W D
WD
D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D011796:Quinacrine
D009838:Oligodeoxyribonucleotides; D004247:DNA; D011796:Quinacrine