title: Phacoanaphylaxis in Behçet's disease: a clinicopathologic and immunohistochemical study.
abstract: OBJECTIVE
  To describe the occurrence of phacoanaphylaxis in enucleated eyes of patients with Behçet's disease.
  
  
  METHODS
  Retrospective, observational, case series and human tissue study.
  
  
  METHODS
  Twenty-six patients with Behçet's disease who underwent enucleation.
  
  
  METHODS
  Histopathologic analysis was performed on 28 enucleated eyes of 26 patients with Behçet's disease. The eyes were divided into two groups, based on the absence or presence of tractional retinal detachment associated with cyclitic membrane formation. Selected eyes with tractional retinal detachment were stained for immunohistochemical examination.
  
  
  METHODS
  Histopathologic examination of enucleated eyes, including routine histopathologic and immunohistochemical studies.
  
  
  RESULTS
  None of the five eyes without retinal detachment showed phacoanaphylaxis. Nine of the 23 eyes with detachment exhibited phacoanaphylaxis, 10 showed no inflammation of the lens, and four were aphakic. There was marked inflammatory cell infiltration in the cyclitic membrane of all nine eyes with phacoanaphylaxis. Immunohistochemical examination demonstrated positive staining for the macrophage markers in the epithelioid and giant cells. The average interval between onset of the ocular manifestations of Behçet's disease and enucleation was 63 months for eyes with phacoanaphylaxis and 35 months for eyes without phacoanaphylaxis (P<0.005).
  
  
  CONCLUSIONS
  In Behçet's disease, eyes with long-standing intraocular inflammation complicated by cyclitic membrane formation may develop phacoanaphylaxis. Such patients may benefit from surgical removal of the cyclitic membrane along with the lens in eyes with significant visual function.
authors.affiliation: Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 7-15-703 Kuromon, Chuo-ku, Fukuoka 810-0055, Japan. inomata@eye.med.kyushu-u.ac.jp
authors.forename: Hajime
authors.initials: H
authors.lastname: Inomata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Narsing A
authors.initials: NA
authors.lastname: Rao
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000209:etiology* / Q000473:pathology; D001528:Behcet Syndrome / Q000150:complications*; D009877:Endophthalmitis / Q000209:etiology; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D007905:Lens Diseases / Q000209:etiology* / Q000473:pathology; D007908:Lens, Crystalline / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012163:Retinal Detachment / Q000209:etiology; D012189:Retrospective Studies