title: [Antibodies to H+/K+-ATPase of gastric parietal cells in children with Helicobacter pylori associated chronic gastritis].
abstract: 54 children at the age of 3-15 suffering from HP-associated CG were examined. Antibodies to H+/K(+)-ATPase of gastric parietal cells were determined with the help of the immune-enzyme analysis method. It was discovered that antibodies to H+/K(+)-ATPase are found in 27.7% of children. Concomitant autoimmune diseases, pangastritis, morphologic symptoms of the pre-atrophic stage of autoimmune gastritis as well as the drop of secretion at the fasting phase were discovered more often in antibody-positive patients. The successful eradication of HP in two children resulted in the disappearance of anti-parietal autoantibodies.
authors.affiliation: I.I. Mechnikov State Medical Academy, Saint Petersburg.
authors.forename: E I
authors.initials: EI
authors.lastname: Tkachenko
authors.forename: V P
authors.initials: VP
authors.lastname: Novikova
authors.forename: P V
authors.initials: PV
authors.lastname: Antonov
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Liubimov
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005757:Gastritis, Atrophic / Q000276:immunology / Q000382:microbiology; D017506:H(+)-K(+)-Exchanging ATPase; D016481:Helicobacter Infections / Q000276:immunology*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D010295:Parietal Cells, Gastric / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D017506:H(+)-K(+)-Exchanging ATPase