title: Synthesis, biophysical, and biochemical properties of PNA-DNA chimeras.
abstract: Three PNA-DNA chimeric dimer synthons (tT, upT and uhT, see Sch. 1) have been synthesized in solution and used to make T20-analogue chimeras applying standard solid-phase DNA synthesis protocol. Duplex forming ability of chimeras with dA20 and their hydrolyses by 3'- and 5'-exonucleases (snake venom and bovine spleen phosphodiesterase, respectively) have been investigated.
authors.affiliation: Chemical Research Center, Institute of Chemistry, Hungarian Academy of Sciences, Budapest, Hungary. bajor@chemres.hu
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Bajor
authors.forename: Gyula
authors.initials: G
authors.lastname: Sági
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Tegyey
authors.forename: László
authors.initials: L
authors.lastname: Otvös
mesh_terms: D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D019281:Dimerization; D007202:Indicators and Reagents; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000737:chemistry*
chemical_list: D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D020135:Peptide Nucleic Acids; D004247:DNA