title: Metabolic polymorphisms and the micronucleus frequency in buccal epithelium of adolescents living in an urban environment.
abstract: Micronuclei and other biomarkers were evaluated in oral cells from 11- to 16-year-old girls living in a foster home in the central area of México City. Variables analyzed for possible association with these biomarkers include smoking habits, body mass index, metabolic polymorphisms for NAT1 and GSTM1 and whether the cells were obtained from the cheek or pharynx. The results indicated that individuals having the NAT1*10 homozygous genotype showed a significant increase in chromatin buds and binucleated cells. When the damage in the cheek was compared with damage in the pharynx, a significant increase in micronuclei and binucleated cells was found for the latter tissue in all the individuals analyzed.
authors.affiliation: Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), México, D.F. dorinda@servidor.unam.mx
authors.forename: Regina
authors.initials: R
authors.lastname: Montero
authors.forename: Luis
authors.initials: L
authors.lastname: Serrano
authors.forename: Víctor
authors.initials: V
authors.lastname: Dávila
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Segura
authors.forename: Andrea
authors.initials: A
authors.lastname: Arrieta
authors.forename: Raquel
authors.initials: R
authors.lastname: Fuentes
authors.forename: Iris
authors.initials: I
authors.lastname: Abad
authors.forename: Lucía
authors.initials: L
authors.lastname: Valencia
authors.forename: Patricia
authors.initials: P
authors.lastname: Sierra
authors.forename: Rafael
authors.initials: R
authors.lastname: Camacho
mesh_terms: D000293:Adolescent; D001191:Arylamine N-Acetyltransferase / Q000235:genetics; D001483:Base Sequence; D015415:Biomarkers; D015992:Body Mass Index; D001835:Body Weight; D017931:DNA Primers; D005260:Female; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008297:Male; D015162:Micronucleus Tests; D009061:Mouth Mucosa / Q000378:metabolism / Q000648:ultrastructure*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011795:Surveys and Questionnaires; D014505:Urban Population
chemical_list: D015415:Biomarkers; D017931:DNA Primers; D007527:Isoenzymes; D001191:Arylamine N-Acetyltransferase; C089384:N-acetyltransferase 1; D005982:Glutathione Transferase