Extracellular matrix protein 1 (ECM1) is over-expressed in malignant epithelial tumors.
The extracellular matrix protein 1 (ECM1) is a secreted protein that has been implicated with cell proliferation, angiogenesis and differentiation. In the present study, we used immunohistochemical staining to examine the expression of ECM1 in a panel of human tumors and found that it was closely correlated with some types of tumors including: invasive breast ductal carcinoma (83%), esophageal squamous carcinoma (73%), gastric cancer (88%) and colorectal cancer (78%). Significantly, ECM1expression was correlated with the metastatic properties of the tumors. Primary breast cancers that had formed metastases were 76% positive while those that had not metastasized were only 33% positive. ECM1 expression was also correlated with PCNA a marker for proliferation, but not with CD34, a marker for endothelial cells. These results indicate that ECM1 tends to be preferentially expressed by metastatic epithelial tumors.
Wang
Luping
L
Department of Oncology, Lombardi Cancer Center, Georgetown University, 3970 Reservoir Road, NW, Washington, DC 20007, USA.
Yu
Jiyao
J
Ni
Jian
J
Xu
Xue-Ming
XM
Wang
Jianjin
J
Ning
Haoyong
H
Pei
Xu-Fang
XF
Chen
Jinguo
J
Yang
Shanmin
S
Underhill
Charles B
CB
Liu
Lei
L
Liekens
Joeri
J
Merregaert
Joseph
J
Zhang
Lurong
L
D018952:Antigens, CD34 / Q000378:metabolism; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism*; D002455:Cell Division; D016326:Extracellular Matrix Proteins / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism*; D009389:Neovascularization, Pathologic; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism
D018952:Antigens, CD34; D014408:Biomarkers, Tumor; C490607:ECM1 protein, human; D016326:Extracellular Matrix Proteins; D018809:Proliferating Cell Nuclear Antigen