Anemia and hepatosplenomegaly as presenting features in a child with rickets and secondary myelofibrosis.
Anemia and hepatosplenomegaly are common reasons for referring a child to a pediatric hematologist or oncologist. Among the many causes for these findings is severe rickets, which has been shown to be associated with secondary myelofibrosis and myeloid metaplasia. The authors present the case of an infant with severe rickets and secondary myelofibrosis and review the differential diagnosis of hepatosplenomegaly from the viewpoint of the pediatric hematologist/oncologist.
Gruner
Barbara A
BA
Department of Pediatrics, University of Texas Health Science Center, San Antonio, Texas, USA.
DeNapoli
Thomas S
TS
Elshihabi
Said
S
Britton
Howard A
HA
Langevin
Anne-Marie
AM
Thomas
Paul J
PJ
Weitman
Steven D
SD
D000740:Anemia / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D002117:Calcitriol / Q000627:therapeutic use; D003937:Diagnosis, Differential; D006529:Hepatomegaly / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D055728:Primary Myelofibrosis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D012279:Rickets / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D013163:Splenomegaly / Q000150:complications* / Q000175:diagnosis / Q000473:pathology
D002117:Calcitriol