Correlation between the Banff 97 classification of renal allograft biopsies and clinical outcome.
The 1997 fourth Banff meeting revised the consensus for describing transplant biopsies. We have conducted a retrospective analysis of biopsies correlated between the Banff 97 classification and clinical outcome. The patients ( n=149), who had a total of 404 biopsy-proven rejections, were assessed and the biopsies taken from these patients were re-examined and classified according to the Banff 97 classification. Morphological changes in the glomeruli (g), interstitium (i), tubules(t), and arterial vessels (v) were scored. Severity of acute rejection was statistically associated with unresponsiveness to anti-rejection treatment ( P<0.0001) and predicted an increased risk of graft failure ( P<0.05). Each quantitative criterion (g, i, t, and v) was also statistically associated with unresponsiveness to anti-rejection treatment. Mean serum creatinine levels were significantly higher in the groups graded Banff 97 type I-III after 1 and 2 years of follow-up. The Banff 97 classification correlated with reversibility of rejection episodes and long-term graft survival.
Tanaka
Toshiyuki
T
Department of Urology, Gunma University School of Medicine, Maebashi City, Gunma, Japan.
Kyo
Masahiro
M
Kokado
Yukito
Y
Takahara
Shiro
S
Hatori
Motoaki
M
Suzuki
Kazuhiro
K
Hasumi
Masaru
M
Toki
Kiyohide
K
Ichimaru
Naotsugu
N
Yazawa
Koji
K
Hanafusa
Toru
T
Namba
Yukiomi
Y
Oka
Kazumasa
K
Moriyama
Toshiki
T
Imai
Enyu
E
Okuyama
Akihiko
A
Yamanaka
Hidetoshi
H
D001706:Biopsy; D006084:Graft Rejection / Q000453:epidemiology / Q000473:pathology; D006085:Graft Survival / Q000502:physiology; D006650:Histocompatibility Testing; D006801:Humans; D007564:Japan; D016030:Kidney Transplantation / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D015203:Reproducibility of Results; D012189:Retrospective Studies; D016019:Survival Analysis; D014184:Transplantation, Homologous / Q000473:pathology*; D017211:Treatment Failure; D016896:Treatment Outcome