[Upper mesenteric venous thrombosis revealing familial resistance to activated protein C].
BACKGROUND
Mesenteric venous thrombosis is a rare disease but potentially severe because of the prognosis of intestinal infarction with high mortality rate (60%).


METHODS
We report the case of a 55 year-old man who presented with an upper mesenteric venous thrombosis related to a familial resistance to C reactive protein through factor V Leiden mutation.


CONCLUSIONS
The discovery of a mesenteric venous thrombosis requires aetiological research that is usually multifactorial. Among the most frequent genetic coagulation abnormalities observed resistance to C reactive protein due to G202110A prothrombin gene mutation is the most common. Although factor V Leiden mutation is less frequent, it requires anticoagulation therapy for life in the case of the appearance of a thrombosis.
Grimaud
Laurent
L
Service d'anesthésie-réanimation, Hôpital du Val de Grâce, Paris. GRIMS@caramail.com
Defuentes
Gilles
G
Duvic
Christian
C
Leveque
Christian
C
Brinquin
Louis
L
D020016:Activated Protein C Resistance / Q000175:diagnosis / Q000235:genetics*; D018450:Disease Progression; D005165:Factor V / Q000235:genetics*; D006580:Genetic Carrier Screening; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007238:Infarction / Q000175:diagnosis / Q000235:genetics / Q000601:surgery; D007421:Intestine, Small / Q000098:blood supply; D008297:Male; D008641:Mesenteric Vascular Occlusion / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D008642:Mesenteric Veins; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D013927:Thrombosis / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D014057:Tomography, X-Ray Computed
C095381:factor V Leiden; D005165:Factor V; D006493:Heparin