GC-MS quantitation of fragrance compounds suspected to cause skin reactions. 1.
Recent changes in European legislation require monitoring of 24 volatile compounds in perfumes as they might elicit skin sensitization. This paper reports a GC-MS quantitation procedure for their determination in fragrance concentrates. GC and MS conditions were optimized for a routine use: analysis within 30 min, solvent and internal standard selection, and stock solution stability. Calibration curves were linear in the range of 2-100 mg/L with coefficients of determination in excess of 0.99. The method was tested using real perfumes spiked with known amounts of reference compounds.
Chaintreau
Alain
A
Analytical Working Group of the International Fragrance Association (IFRA), Square Marie-Louise 49, B-1000 Brussels, Belgium. alain.chaintreau@firmenich.com
Joulain
Daniel
D
Marin
Christophe
C
Schmidt
Claus-Oliver
CO
Vey
Matthias
M
D000485:Allergens / Q000032:analysis*; D003877:Dermatitis, Contact / Q000209:etiology*; D008401:Gas Chromatography-Mass Spectrometry; D010476:Perfume / Q000737:chemistry*; D011786:Quality Control; D012997:Solvents; D014835:Volatilization
D000485:Allergens; D010476:Perfume; D012997:Solvents