Mononucleoside SATE glucosyl phosphorothiolates as a new series of pronucleotides.
The synthesis and the study of two phosphorothiolate derivatives of 3'-azido-2',3'-dideoxythymidine (AZT) bearing a S-pivaloyl-2-thioethyl (tBuSATE) group and glucosyl residues associated to the phosphorus atom by a 2-oxyethyl link, are reported. These derivatives could be considered as prototypes of a new series of nucleotide prodrugs (pronucleotides).
Jochum
A
A
Université Montpellier II, UMR 5625 CNRS, Montpellier, France.
Schlienger
N
N
Gosselin
G
G
Imbach
J L
JL
Aubertin
A M
AM
Périgaud
C
C
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry; D015215:Zidovudine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
D000998:Antiviral Agents; D009705:Nucleosides; D011355:Prodrugs; D015215:Zidovudine