title: Effects of fibrin glue on wound healing in oral cavity.
abstract: OBJECTIVE
  Healing after oral cavity surgery may be problematic in some cases, because it is a contaminated cavity. The purpose of this investigation was to evaluate the effect of fibrin glue on healing after surgical procedures in the oral cavity.
  
  
  METHODS
  Forty-two Sprague-Dawley rats were used at this study, 24 in study (Group 1) and 18 in control (Group 2) groups. First molars of the rats were extracted with some cortical bone. The exposed cavities were filled with fibrin glue after hemostasis in study group but 5/0 silk suture was used in control group. The rats were sacrificed after two, four and six weeks and histologic analysis was performed.
  
  
  RESULTS
  Healing was better in the study group. Foreign body reaction was lower in Group 1 (1/24, 4.1%) than Group 2 (6/18, 33.3%) (p<0.05). Also abcess formation scores were better in Group 1 (3/24, 12.5%) than Group 2 (10/18, 55.5%) (p<0.008, chi(2)=7). The last significant difference was on necrosis and better results were obtained in Group 1 (2/24, 8.3%) than Group 2 (10/18, 55.5%) (p<0.001, chi(2)=11.24).
  
  
  CONCLUSIONS
  The use of fibrin glue on wound healing in the oral cavity has a positive effect when compared with traditional suture techniques.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Istanbul University, Mehtap Sok. Baran Sitesi No. 10/15 Bahçelievler, Istanbul, Turkey. eayucel@superonline.com.tr
authors.forename: Emre A
authors.initials: EA
authors.lastname: Yücel
authors.forename: Okhan
authors.initials: O
authors.lastname: Oral
authors.forename: Vakur
authors.initials: V
authors.lastname: Olgaç
authors.forename: Cüneyt K
authors.initials: CK
authors.lastname: Oral
mesh_terms: D000038:Abscess / Q000209:etiology; D000818:Animals; D016009:Chi-Square Distribution; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D005549:Foreign-Body Reaction / Q000209:etiology; D006488:Hemostasis, Surgical; D008334:Mandible / Q000601:surgery; D009055:Mouth / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D009336:Necrosis; D016155:Oral Fistula / Q000209:etiology; D011183:Postoperative Complications; D051381:Rats; D017207:Rats, Sprague-Dawley; D013536:Suture Techniques; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014081:Tooth Extraction; D020390:Tooth Socket / Q000601:surgery; D014945:Wound Healing / Q000187:drug effects
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives