In vivo performance and biocompatibility of the MagScrew ventricular assist device.
Currently available ventricular assist devices (VADs) have limitations in long-term durability and blood compatibility. We evaluated a prototype of a pulsatile MagScrew VAD for in vivo hemodynamic performance and biocompatibility. The device is composed of an actuator, blood pump housing, diaphragm, pusher plate, and bioprosthetic valves. Its protein-coated ("biolized") blood-contacting surface inhibits clot formation. Forces between moving parts of the actuator are transmitted magnetically, eliminating a primary source of friction and wear. The pump fills passively and is highly preload sensitive. The device was implanted into three calves for 90, 10, and 57 days, respectively. No anticoagulants were given postoperatively. The device functioned without technical problems during the entire course of each experiment, with mean device flow ranging between 5.4 and 9.0 L/min. Autopsy of the first two calves revealed no sign of embolization and clean blood-contacting surfaces of the devices. The third experiment was complicated by a prosthetic valve endocarditis with infectious embolization, and a few small depositions were found in the pump. In conclusion, the MagScrew VAD has demonstrated a high level of performance and biocompatibility in three calves studied for 10-90 days. Vigorous development is in progress to bring this device to preclinical readiness and thus provide surgeons with the VAD of choice for permanent implantation.
Schenk
Soren
S
Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Weber
Stephan
S
Luangphakdy
Viviane
V
Flick
Christine R
CR
Chen
Ji-Feng
JF
Inoue
Masahiro
M
Kopcak
Michael W
MW
Ootaki
Yoshio
Y
Doi
Kazuyoshi
K
Dessoffy
Raymond
R
Hirschman
Gordon B
GB
Vitale
Nicholas G
NG
Chapman
Peter A
PA
Smith
William A
WA
Fukamachi
Kiyotaka
K
D000818:Animals; D002417:Cattle; D020099:Coated Materials, Biocompatible; D004617:Embolism / Q000517:prevention & control*; D005780:Gelatin; D006353:Heart-Assist Devices; D008280:Magnetics / Q000295:instrumentation; D008297:Male
D020099:Coated Materials, Biocompatible; D005780:Gelatin