Macrophage-derived IL-18 targeting for the treatment of Crohn's disease.
Crohn's disease is an inflammatory bowel disease associated with several changes in the immune system, including an increased number of infiltrating macrophages. These macrophages release a variety of proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha, macrophage infiltrating factor (MIF), interleukin (IL)-6, IL-12 and IL-18, which are critically involved in the onset and the development of Crohn's disease. We here focus on the role of macrophages, especially macrophage-derived IL-18 in both patients with Crohn's disease and a murine model of Crohn's disease.
Kanai
Takanori
T
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. taka.gast@tmd.ac.jp
Uraushihara
Koji
K
Totsuka
Teruji
T
Okazawa
Akira
A
Hibi
Toshifumi
T
Oshima
Shigeru
S
Miyata
Tatsuya
T
Nakamura
Tetsuya
T
Watanabe
Mamoru
M
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D003424:Crohn Disease / Q000188:drug therapy* / Q000503:physiopathology; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D006801:Humans; D000922:Immunotoxins / Q000494:pharmacology; D020382:Interleukin-18 / Q000502:physiology*; D008264:Macrophages / Q000502:physiology*; D008562:Membrane Glycoproteins / Q000187:drug effects / Q000502:physiology; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology; D051193:Toll-Like Receptors
D000911:Antibodies, Monoclonal; D000922:Immunotoxins; D020382:Interleukin-18; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors