title: High dose rate intraoperative radiotherapy for recurrent cervical cancer and nodal disease.
abstract: BACKGROUND
  Patients with pelvic sidewall recurrences of cervical cancer have a dismal prognosis. Intraoperative radiation therapy (IORT) has demonstrated encouraging results. Patients have traditionally been excluded from IORT if they had distant metastases.
  
  
  METHODS
  A patient underwent radical tumor resection and high dose rate (HDR) IORT for a pelvic sidewall recurrence of cervical cancer. She also had metastatic disease in a para-aortic node. The patient has been followed for >20 months with no evidence of disease recurrence.
  
  
  CONCLUSIONS
  HDR-IORT may be offered to select patients with recurrent cervical cancer and isolated metastatic para-aortic lymph nodes.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University Medical Center, Box 3079, Durham, NC 27710, USA.
authors.forename: Ted M
authors.initials: TM
authors.lastname: Roth
authors.forename: Angeles Alvarez
authors.initials: AA
authors.lastname: Secord
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Havrilesky
authors.forename: Ellen
authors.initials: E
authors.lastname: Jones
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Clarke-Pearson
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000379:methods*; D005260:Female; D006801:Humans; D007430:Intraoperative Care / Q000379:methods; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy* / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy* / Q000601:surgery