Isosteric phosphonate pyrrolidine-based dinucleoside monophosphate analogues.
A novel alpha- and beta-configured pyrrolidine nucleoside phosphonates in adenine series were synthesized from trans-4-hydroxy-L-proline as starting material. d(ApA) analogues were also prepared and studied with respect to their hybridization properties with polyU.
Vanek
Václav
V
Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Prague, Czech Republic.
Budesínský
Milos
M
Kavenová
Ivana
I
Rinnová
Markéta
M
Rosenberg
Ivan
I
D000241:Adenosine / Q000737:chemistry; D001665:Binding Sites; D015226:Dinucleoside Phosphates / Q000737:chemistry*; D006909:Hydroxyproline; D007202:Indicators and Reagents; D009711:Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis; D063065:Organophosphonates / Q000737:chemistry*; D011072:Poly U / Q000737:chemistry; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism
D015226:Dinucleoside Phosphates; D007202:Indicators and Reagents; D009711:Nucleotides; D009841:Oligonucleotides; D063065:Organophosphonates; D011759:Pyrrolidines; D011072:Poly U; D000241:Adenosine; D006909:Hydroxyproline