An industrial process for synthesizing Lodenosine (FddA).
Two industrial synthetic approaches to Lodenosine (1, FddA, 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl) adenine) via a purine riboside or a purine 3'-deoxyriboside are described. Several novel applications of deoxygenation and fluorination methods are compared considering reaction yields, economy, safety and environmental concerns.
Izawa
Kunisuke
K
AminoScience Laboratories, Ajinomoto Co., Inc., Kawasaki-ku, Kawasaki, Japan. kunisuke_izawa@ajinomoto.com
Takamatsu
Satoshi
S
Katayama
Satoshi
S
Hirose
Naoko
N
Kozai
Shigetaka
S
Maruyama
Tokumi
T
D016048:Dideoxyadenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry*; D004345:Drug Industry / Q000379:methods; D007202:Indicators and Reagents; D008968:Molecular Conformation
D007202:Indicators and Reagents; C073072:lodenosine; D016048:Dideoxyadenosine