title: [Effects of Peristrophe roxburghiana on blood pressure. NO and ET in renal hypertensive rats].
abstract: OBJECTIVE
  To observe the effects of Peristrophe roxbrughiana (HSX) on blood pressure, NO, No-synthase and ET in the serum and NO in urine in renal hypertensive rats.
  
  
  METHODS
  The 2K1C(2 kidney 1 clap) hypertensive model rats were used and drugs had been given by ig. for 4 weeks. The blood pressure was measured at the end of the each week. At the end of 4th week, the urine was collected and the concentration of NO in the serum or urine, NO-synthease and ET in the serum were measured.
  
  
  RESULTS
  HSX (H or L dosage) by ig. for 1 week can significantly lower the blood pressure, increase the levels of NO and NO-synthase in the serum and NO in the urine, reduce the concentration of ET in the serum. The effects have lasted for 4 weeks.
  
  
  CONCLUSIONS
  HSX played an important role in the renal hypertensive rats.
authors.affiliation: Pharmacy College of Jinan University, Guangzhou 510632.
authors.forename: Xudan
authors.initials: X
authors.lastname: Zhuang
authors.forename: Junhua
authors.initials: J
authors.lastname: Lü
authors.forename: Wenzhong
authors.initials: W
authors.lastname: Yang
authors.forename: Meiling
authors.initials: M
authors.lastname: Yang
mesh_terms: D027901:Acanthaceae / Q000737:chemistry*; D000818:Animals; D000959:Antihypertensive Agents / Q000302:isolation & purification / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D016232:Endothelins / Q000097:blood*; D006978:Hypertension, Renovascular / Q000097:blood* / Q000503:physiopathology; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000097:blood; D052250:Nitric Oxide Synthase Type III; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000959:Antihypertensive Agents; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat