Piericidins C5 and C6: new 4-pyridinol compounds produced by Streptomyces sp. and Nocardioides sp.
Piericidins C5 (1) and C6 (2), two new members of the piericidin family, were isolated from a Streptomyces sp. and a Nocardioides sp., together with known piericidins C1 (3), C2 (4), C3 (5), C4 (6), D1 (7), and A3 (8). The structures were determined on the basis of their spectroscopic data. Both new compounds inhibited cell division of fertilized starfish (Asterina pectinifera) eggs at the minimum inhibitory concentration of 0.09 microg/mL.
Kubota
Natsuki K
NK
Instrument Center for Chemical Analysis, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan.
Ohta
Emi
E
Ohta
Shinji
S
Koizumi
Fumito
F
Suzuki
Makoto
M
Ichimura
Michio
M
Ikegami
Susumu
S
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D009618:Nocardiaceae / Q000378:metabolism*; D011725:Pyridines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D011728:Pyridones; D013215:Starfish / Q000737:chemistry / Q000187:drug effects; D013302:Streptomyces / Q000378:metabolism*
D011725:Pyridines; D011728:Pyridones; C487579:piericidin C5; C487580:piericidin C6; C534143:4-pyridone