title: New lipophilic derivatives of AZT and d4T 5'-phosphonates.
abstract: 5'-Aminocarbonylphosphonyl and aminocarbonylmethylphosphonyl diesters of AZT and d4T were synthesized as potential anti-HIV agents.
authors.affiliation: Engelhardt Institute of Molecular Biology Russian Academy of Sciences, Moscow, Russia. aak@imb.ac.ru
authors.forename: Elena A
authors.initials: EA
authors.lastname: Shirokova
authors.forename: Maxim V
authors.initials: MV
authors.lastname: Jasko
authors.forename: Anastasiya L
authors.initials: AL
authors.lastname: Khandazhinskaya
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Yanvarev
authors.forename: Yury S
authors.initials: YS
authors.lastname: Skoblov
authors.forename: Tatyana R
authors.initials: TR
authors.lastname: Pronayeva
authors.forename: Nina V
authors.initials: NV
authors.lastname: Fedyuk
authors.forename: Andrey G
authors.initials: AG
authors.lastname: Pokrovsky
authors.forename: Marina K
authors.initials: MK
authors.lastname: Kukhanova
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D004355:Drug Stability; D015497:HIV-1 / Q000187:drug effects*; D006207:Half-Life; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D063065:Organophosphonates; D018119:Stavudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects; D015215:Zidovudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D063065:Organophosphonates; D015215:Zidovudine; D018119:Stavudine