Methylated hexitol nucleic acids, towards congeners with improved antisense potential.
In an effort to further improve the hybridisation potential of anhydro-hexitol nucleoside analogues, the 1'-methoxyl and 3'-methoxyl substituents were introduced and evaluated for their antisense potential. In view of the selectivity of pairing with RNA, especially the introduction of a 3'-O-alkyl moiety deserves further study.
Van Aerschot
A
A
Laboratory for Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium. arthur.vanaerschot@rega.kuleuven.ac.be
Marchand
A
A
Schepers
G
G
Van den Eynde
W
W
Rozenski
J
J
Busson
R
R
Herdewijn
P
P
D000438:Alcohols; D000478:Alkylation; D008745:Methylation; D009696:Nucleic Acids / Q000138:chemical synthesis*; D009705:Nucleosides / Q000138:chemical synthesis
D000438:Alcohols; D009696:Nucleic Acids; D009705:Nucleosides