title: Determination of the absolute P-configuration of a phthalidyl-phosphonate thymidine-thymidine dimer.
abstract: Phthalidyl modified oligonucleotide thymidine-thymidine dimer building blocks were synthesized via the H-phosphonate-method. The compounds which are diastereomeric at the phosphorus atom were separated by chromatography and the absolute configuration at the phosphorus atoms was determined using ROE-experiments using the corresponding methyl-phosphonates.
authors.affiliation: Institute of Organic Chemistry, University of Hamburg, Hamburg, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Fendrich
authors.forename: C
authors.initials: C
authors.lastname: Meier
mesh_terms: D008958:Models, Molecular; D008968:Molecular Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D063065:Organophosphonates; D010795:Phthalic Acids; D011740:Pyrimidine Dimers / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D009838:Oligodeoxyribonucleotides; D063065:Organophosphonates; D010795:Phthalic Acids; D011740:Pyrimidine Dimers