title: [Resistance of Neisseria gonorrhoeae to 4 antibiotics: an analysis of the situation in Guangzhou in 2002].
abstract: OBJECTIVE
  To survey the antibiotic resistance and the prevalence of penicillinase-producing and highly tetracycline-resistant Neisseria gonorrhoeae (PPNG and TRNG) in Guangzhou in 2002.
  
  
  METHODS
  Minimum inhibitory concentrations (MIC) of the 4 antimicrobial agents, tetracycline, spectinomycin, ciprofloxacin and ceftriaxone, to 100 strains of Neisseria gonorrhoeae were determined by agar dilution method, and beta-lactamase was detected by iodine quantification method.
  
  
  RESULTS
  There were 15 (15%) strains of PPNG and 28 (28%) strains of TRNG among the 100 strains of Neisseriae gonorrhoeae examined, with a resistant rate to ciprofloxacin as high as 98% and 32 (32%) strains identified to be highly resistant to the antibiotics (MIC >or=16 mg/L). No resistant strains to ceftriaxone and specitinomycin were identified, but ceftriaxone susceptibility of the strains was declining.
  
  
  CONCLUSIONS
  The current antibiotic resistance of gonococci strains are still serious in Guangzhou, especially in the case of ciprofloxacin resistance. The strains are sensitive to spectinomycin and ceftriaxone, and continuous monitoring of the bacteria for their antibiotic resistance is necessary.
authors.affiliation: Institute of Skin Disease Prevention and Therapy of Guangzhou, Guangzhou 510095, China.
authors.forename: Shi
authors.initials: S
authors.lastname: Fei
authors.forename: Quan
authors.initials: Q
authors.lastname: Luo
authors.forename: Wen-ling
authors.initials: WL
authors.lastname: Cao
authors.forename: Xi-bao
authors.initials: XB
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002443:Ceftriaxone / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects*; D000198:Spectinomycin / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D002443:Ceftriaxone; D000198:Spectinomycin; D013752:Tetracycline