Synthesis of some novel imidazolinones as potent anticonvulsant agents.
Imidazolinone derivatives of IIa-IIc, IIIa-IIIf and IVa-IVf have been synthesised by the condensation of some known sulpha drugs with 5-oxazolone derivatives, which were prepared by Erlenmeyer condensation of benzoyl glycine with different aldehydes in the presence of sodium acetate and acetic anhydride. The constitution of the products has been supported by elemental analysis and IR, 1H-NMR spectral data. The products have been screened for their (a) in vitro growth inhibitory activity against several microorganisms and (b) in vivo anticonvulsant activity.
Joshi
Hashmukh
H
Department of Home Science, Saurashtra University, 5, Rajkot, India. hdjoshi1@rediffmail.com
Upadhyay
Paresh
P
Karia
Denish
D
Baxi
A J
AJ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure
D000900:Anti-Bacterial Agents; D000927:Anticonvulsants; D007093:Imidazoles