title: Convergent synthesis and antibacterial activity of pyrazole and pyrazoline derivatives of diazepam.
abstract: Polysubstituted pyrazoles (5)(a-l), pyrazolines (7)(a-c), (8)(a-c) and pyrazolotriazine (10) derivatives of diazepam were synthesized. The structures of hitherto unknown compounds were established by analytical and spectral methods. Some of these compounds were screened to test their antibacterial activity against gram-positive (B. subtilis) and gram-negative (P. aeruginosa). All compounds showed potent activity against these bacteria.
authors.affiliation: Chemistry Department, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt. dal_mag@hotmail.com
authors.forename: Moged A
authors.initials: MA
authors.lastname: Berghot
authors.forename: Evelin B
authors.initials: EB
authors.lastname: Moawad
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D003975:Diazepam / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
chemical_list: D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D011720:Pyrazoles; D003975:Diazepam