title: Myocardial contrast echocardiography (MCE) with triggered ultrasound does not cause premature ventricular complexes: evidence from PB127 MCE studies.
abstract: Previous studies suggest that myocardial contrast echocardiography using high mechanical index triggered ultrasound can be associated with increased frequency of the premature ventricular complex (PVC). However, this association has not been systematically examined. PB127 (Point Biomedical Corp, San Carlos, Calif) is a novel microsphere designed for evaluation of myocardial perfusion with ultrasound. PB127 myocardial contrast echocardiography was performed with triggered harmonic power Doppler in early/mid diastole (mechanical index </= 1.0). A total of 71 patients (cohort A) were studied at rest and another 64 (cohort B, age 62 +/- 12.6 years) were allocated to stress. Continuous electrocardigraphy was recorded. The study evaluated premature ventricular complex frequency at baseline, during, and after infusion of PB127 (dose < 0.175 mg/kg, <60-minute duration). Proportions of triggered and nontriggered intervals associated with premature ventricular complex were determined. PVC frequency did not increase with PB127 infusion in either cohort (P =.572, P =.263). Proportion of triggered intervals after QRS associated with PVC was similar to proportion of untriggered intervals in cohort A (P >.999) and was lower than untriggered intervals (P =.001) in B, suggesting that triggers do not cause PVC. PB127 does not cause increase PVC frequency during or after imaging with triggered ultrasound at mechanical index of 1.
authors.affiliation: University of California San Diego, 92103-8411, USA.
authors.forename: Ajit
authors.initials: A
authors.lastname: Raisinghani
authors.forename: Kevin S
authors.initials: KS
authors.lastname: Wei
authors.forename: Linda
authors.initials: L
authors.lastname: Crouse
authors.forename: Floredeliza
authors.initials: F
authors.lastname: Villanueva
authors.forename: Harvey
authors.initials: H
authors.lastname: Feigenbaum
authors.forename: Nelson B
authors.initials: NB
authors.lastname: Schiller
authors.forename: James
authors.initials: J
authors.lastname: Weiss
authors.forename: Tasneem Z
authors.initials: TZ
authors.lastname: Naqvi
authors.forename: Robert
authors.initials: R
authors.lastname: Siegel
authors.forename: Mark
authors.initials: M
authors.lastname: Monaghan
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Goldman
authors.forename: Anthony
authors.initials: A
authors.lastname: Demaria
mesh_terms: D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003287:Contrast Media / Q000009:adverse effects*; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D018450:Disease Progression; D004452:Echocardiography; D015716:Electrocardiography, Ambulatory; D005080:Exercise Test; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000209:etiology; D015588:Observer Variation; D015995:Prevalence; D013223:Statistics as Topic; D018879:Ventricular Premature Complexes / Q000139:chemically induced* / Q000000981:diagnostic imaging* / Q000453:epidemiology
chemical_list: D003287:Contrast Media