[Study on gamma-synuclein gene in patients with idiopathic Parkinson's disease].
OBJECTIVE
To evaluate the relationship between idiopathic Parkinson's disease (PD) and two polymorphisms (C243G and A377T) of the gamma-synuclein gene in a Chinese Han population of Shanghai area.


METHODS
Polymorphic genotyping was performed with PCR-RPLP technique. Association analysis was carried out in 145 unrelated idiopathic PD patients and 184 age-matched healthy controls.


RESULTS
The authors failed to detect any distributional difference of the C243G and A377T polymorphisms of the gamma-synuclein gene between PD cases and control subjects, nor did they find any association.


CONCLUSIONS
These data do not support that gamma-synuclein gene C243G and A377T polymorphisms are involved in idiopathic PD onset in the Han population of Shanghai area.
Su
Jing-jing
JJ
Department of Neurology, Changhai Hospital, the Second Military Medical University, Shanghai, 200433 P R China. jjsulcg@yahoo.com
Xie
Hui-jun
HJ
Zhao
Wu-wei
WW
Han
Hai-xiong
HX
Gao
Tong
T
Xu
Ling
L
Tang
Guo-mei
GM
Ren
Da-ming
DM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D051843:Synucleins; D051845:gamma-Synuclein
D009419:Nerve Tissue Proteins; D051843:Synucleins; D051845:gamma-Synuclein