title: Death and the retrovirus.
abstract: A flurry of new papers has shown that HIV reverse transcription is vulnerable to G-->A hypermutation. Apparently, cytidine bases in nascent DNA synthesis are lethally edited by the host cell molecule apolipoprotein B editing complex protein (APOBEC) 3G. This death mechanism is circumvented by the HIV viral infectivity factor protein, which prevents APOBEC3G from entering the virion.
authors.affiliation: Unité de Rétrovirologie Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 cedex 15, Paris, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Vartanian
authors.forename: Peter
authors.initials: P
authors.lastname: Sommer
authors.forename: Simon
authors.initials: S
authors.lastname: Wain-Hobson
mesh_terms: D000071480:APOBEC-3G Deaminase; D001483:Base Sequence; D003564:Cytidine Deaminase; D016346:Gene Products, vif / Q000235:genetics / Q000502:physiology; D006678:HIV / Q000235:genetics; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D016296:Mutagenesis / Q000235:genetics*; D009700:Nucleoside Deaminases; D011506:Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012097:Repressor Proteins; D012190:Retroviridae / Q000235:genetics*; D054320:vif Gene Products, Human Immunodeficiency Virus
chemical_list: D016346:Gene Products, vif; D011506:Proteins; D012097:Repressor Proteins; D054320:vif Gene Products, Human Immunodeficiency Virus; D009700:Nucleoside Deaminases; D000071480:APOBEC-3G Deaminase; C464924:APOBEC3G protein, human; D003564:Cytidine Deaminase