title: Cutaneous and pulmonary sarcoidosis in a Hong Kong Chinese woman with silicone breast prostheses.
abstract: Sarcoidosis is rarely reported in Hong Kong. We report cutaneous and pulmonary sarcoidosis in a 54-year-old Chinese woman, who presented with papular lesions over the face and neck. She had silicone breast augmentation surgery 4 years earlier. Skin biopsy revealed granulomatous inflammation and anti-tuberculosis treatment was started empirically but stopped 2 months later owing to a poor response. A right supraclavicular lymph node was aspirated and revealed granulomatous inflammation. The CXR was normal initially but subsequently showed diffuse reticulonodular opacities and a small right-sided pleural effusion. High-resolution CT of the thorax showed mediastinal lymphadenopathy and diffuse perilymphatic nodular opacities consistent with sarcoidosis. Sputum mycobacterial culture was negative. Fibreoptic bronchoscopy showed no endobronchial lesion but the transbronchial biopsy showed granulomatous inflammation with no evidence of infection, malignancy or foreign body. Pulmonary function tests were normal except for impairment of transfer factor. One year later, most of the cutaneous lesions had healed spontaneously. The CXR showed partial improvement of the right pleural opacification but little change in the lung field. The features of sarcoidosis and its association with silicone are reviewed.
authors.affiliation: Department of Health, Ruttonjee Hospital, Hong Kong SAR, China. ymtcc.dh.gov.hk
authors.forename: Kwok-Chiu
authors.initials: KC
authors.lastname: Chang
authors.forename: Kam-Tim
authors.initials: KT
authors.lastname: Chan
authors.forename: Lai-Yin
authors.initials: LY
authors.lastname: Chong
authors.forename: Kam-Shing
authors.initials: KS
authors.lastname: Lau
authors.forename: Cheuk-Ming
authors.initials: CM
authors.lastname: Tam
authors.forename: Chak-Wah
authors.initials: CW
authors.lastname: Lam
mesh_terms: D018427:Breast Implants / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006723:Hong Kong; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D012129:Respiratory Function Tests; D012507:Sarcoidosis / Q000175:diagnosis* / Q000209:etiology; D017565:Sarcoidosis, Pulmonary / Q000175:diagnosis / Q000209:etiology; D012826:Silicone Elastomers / Q000009:adverse effects*; D012871:Skin Diseases / Q000175:diagnosis* / Q000209:etiology; D014057:Tomography, X-Ray Computed
chemical_list: D012826:Silicone Elastomers