Scintigraphy with [111In]octreotide and 201Tl in a Hürthle cell thyroid carcinoma without detectable radio-iodine uptake. Report of a case and review of the literature.
OBJECTIVE
To describe the visualization of recurrent disease by [111In]octreotide and 201Tl scintigraphy in a patient with Hürthle cell thyroid carcinoma, increased thyroglobulin levels, and a negative radio-iodine total-body scan.


METHODS
Scintigraphy with [111In]octreotide and 201Tl was performed, and a local recurrence in the thyroid bed was detected which was excised by surgery.


RESULTS
On histology, the tumour proved to be a Hürthle cell carcinoma, and within the tumour somatostatin receptors were detected by RT-PCR.


CONCLUSIONS
Scintigraphy with [111In]octreotide and 201Tl is an alternative imaging method for the detection of residual disease in patients with a differentiated thyroid carcinoma having increased thyroglobulin levels and a negative radio-iodine total-body scan.
Kostoglou-Athanassiou
I
I
Department of Endocrinology, Metaxa Hospital, Piraeus, Greece.
Pappas
A
A
Gogou
L
L
Kaldrymides
P
P
D018249:Adenoma, Oxyphilic / Q000000981:diagnostic imaging* / Q000601:surgery; D006801:Humans; D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000601:surgery; D015282:Octreotide; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000378:metabolism; D013794:Thallium Radioisotopes; D013954:Thyroglobulin / Q000032:analysis; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery
D007205:Indium Radioisotopes; D007457:Iodine Radioisotopes; D017481:Receptors, Somatostatin; D013794:Thallium Radioisotopes; D013954:Thyroglobulin; D015282:Octreotide