title: Lack of asparagine depletion in the cerebrospinal fluid after one intravenous dose of PEG-asparaginase: a window study at initial diagnosis of childhood ALL.
authors.forename: I M
authors.initials: IM
authors.lastname: Appel
authors.forename: J P V
authors.initials: JP
authors.lastname: Pinheiro
authors.forename: M L
authors.initials: ML
authors.lastname: den Boer
authors.forename: C
authors.initials: C
authors.lastname: Lanvers
authors.forename: N C M
authors.initials: NC
authors.lastname: Reniers
authors.forename: J
authors.initials: J
authors.lastname: Boos
authors.forename: R
authors.initials: R
authors.lastname: Pieters
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D001216:Asparagine / Q000134:cerebrospinal fluid* / Q000172:deficiency; D002648:Child; D006801:Humans; D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000134:cerebrospinal fluid* / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D011092:Polyethylene Glycols; D001216:Asparagine; C042705:pegaspargase; D001215:Asparaginase