title: Long-term follow-up of women hospitalized for acute pyelonephritis.
abstract: Long-term outcome of acute pyelonephritis (AP) in adults is unknown. We evaluated the frequency of renal damage 10-20 years after hospitalization for AP in adult women and the utility of technetium Tc 99m-labeled dimercaptosuccinic acid (Tc 99m-DMSA) scanning for detection of renal scars; 63 of 203 women hospitalized with AP during 1982-1992 were included in the study. Tc 99m-DMSA scanning detected renal scarring in 29 women (46%). Multivariate analysis showed that pregnancy and hypoalbuminemia (albumin level, <3.2 g/dL) at hospitalization were independent risk factors for subsequent development of renal scars. At follow-up, hypertension was observed in approximately one-fifth of patients, regardless of renal scarring status. Four women with scars had a glomerular filtration rate of < or =75 mL/min; none of them developed severe renal impairment. In conclusion, the risk of developing renal scarring after AP in adult women is high. However, clinically relevant renal damage is rare 10-20 years after AP. Tc 99m-DMSA scanning is useful for detecting renal scars in adults but is not routinely needed in practice.
authors.affiliation: Infectious Diseases Unit, Haemek Medical Center, Afula, 18 101, Israel. raz_r@clalit.org.il
authors.forename: Raul
authors.initials: R
authors.lastname: Raz
authors.forename: Waheeb
authors.initials: W
authors.lastname: Sakran
authors.forename: Bibiana
authors.initials: B
authors.lastname: Chazan
authors.forename: Raul
authors.initials: R
authors.lastname: Colodner
authors.forename: Calvin
authors.initials: C
authors.lastname: Kunin
mesh_terms: D000208:Acute Disease; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011704:Pyelonephritis / Q000150:complications*; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014552:Urinary Tract Infections / Q000175:diagnosis
chemical_list: D019783:Technetium Tc 99m Dimercaptosuccinic Acid