title: [Effect of alpha-tocopherol and synthetic antioxidants on morpho-functional status of gonadotropic cells from the adenohypophysis of albino rats].
abstract: Morphometric indices of gonadotropic cells obtained from adenohypophysis of white rats, both males and females, were investigated after treatment with alpha-tocopherol and synthetic antioxidants. The former stimulated the functional status of gonadotropic cells revealed in a proportional increase in both nuclear and cytoplasmic volumes. After the treatment with a synthetic antioxidant dibunolum, the volume of the cytoplasm increased in gonadotropic cells of rats of different sexes. After the treatment with a water-soluble antioxidant emoxipinum, the volume of the cytoplasm in gonadotropic cells increased only in males. The outcomes allow to consider alpha-tocopherol, in contrast to from synthetic antioxidants, as one of the modulators of the functional state of gonadotropic cells obtained from adenohypophysis.
authors.affiliation: Faculty of Anatomy and Physiology of Man and Animals, Astrakhan' State Pedagogical University.
authors.forename: M V
authors.initials: MV
authors.lastname: Kozak
authors.forename: D L
authors.initials: DL
authors.lastname: Teplyĭ
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage / Q000494:pharmacology*; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D007273:Injections, Intramuscular; D008297:Male; D010847:Picolines / Q000008:administration & dosage / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D024502:alpha-Tocopherol / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D010847:Picolines; D002084:Butylated Hydroxytoluene; D024502:alpha-Tocopherol; C009820:6-methyl-2-ethyl-3-hydroxypyridine