Spontaneous anaplasia in pilocytic astrocytoma of cerebellum.
We report a cystic cerebellar astrocytoma with a mural nodule that contained an additional focus of astrocytoma with the histological features of anaplasia, and showed up to 48% of aneuploid and 3% S-phase cells on flow cytometry. This focus was detectable on the enhanced, as well as non-enhanced T1 and T2 images. This appears to be the first case of pilocytic astrocytoma of cerebellum with focal anaplasia detected on histological and radiological studies.
Lach
B
B
Department of Pathology & Laboratory Medicine, King Faisal Specialist Hospital & Research Centre, Riyadh, Kingdom of Saudi Arabia. boleklach@hotmail.com
Al Shail
E
E
Patay
Z
Z
D000708:Anaplasia / Q000000981:diagnostic imaging / Q000473:pathology; D001254:Astrocytoma / Q000000981:diagnostic imaging / Q000473:pathology*; D002528:Cerebellar Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000473:pathology*; D002648:Child; D003560:Cysts / Q000000981:diagnostic imaging / Q000473:pathology; D004171:Diploidy; D005434:Flow Cytometry; D016193:G1 Phase; D006801:Humans; D008297:Male; D014057:Tomography, X-Ray Computed / Q000379:methods