title: Synthesis and cytotoxic activity of some new azapyranoxanthenone aminoderivatives.
abstract: A series of novel azapyranoxanthenones, bearing structural similarity to the acridone alkaloid acronycine have been designed and synthesized. Their in vitro cytotoxicities against the murine L1210 leukemia and the human solid tumor HT-29 cell lines have been investigated. The new derivatives exhibited interesting cytotoxic activity and were more potent than the parent compound.
authors.affiliation: Division of Pharmaceutical Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Kolokythas
authors.forename: Ioannis K
authors.initials: IK
authors.lastname: Kostakis
authors.forename: Nicole
authors.initials: N
authors.lastname: Pouli
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Marakos
authors.forename: Dimitris
authors.initials: D
authors.lastname: Kletsas
authors.forename: Harris
authors.initials: H
authors.lastname: Pratsinis
mesh_terms: D000166:Acridines / Q000737:chemistry; D054831:Acridones; D000175:Acronine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D018797:Cell Cycle Proteins / Q000032:analysis; D045744:Cell Line, Tumor; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice
chemical_list: D000166:Acridines; D054831:Acridones; D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins; C041300:acridone; D000175:Acronine