[Use of clonazepam for treatment of patients with paroxysmal atrial fibrillation with regard to their psychoautonomic status].
OBJECTIVE
To study the efficacy of clonazepam in patients with paroxysmal atrial fibrillation (PAF) with reference to their psychovegetative status.


METHODS
50 patients with PAF of non-rheumatic origin entered the study group, 20 healthy examinees served control. All of them were examined using a clinicocardiological, cliniconeurological tests; their autonomic nervous system, emotional sphere, sleep disorders were studied before and after clonazepam treatment in a dose 0.5 mg 2 times a day for 30 days.


RESULTS
A positive effect of clonazepam was noted in 20 (80%) patients with PAF, less frequent paroxysms occurred in 12 (48%) patients, in 5 patients they stopped, 12 (48%) patients tolerated the paraxysms better. The paraxysms became shorter in 10 (40%) patients, 10 (40%) patients felt better in the postparoxysmal period. A marked relief of psychovegetative syndrome, improvement of activity, mood and quality of sleep were noted in all the patients.


CONCLUSIONS
Clonazepam is recommended for patients with PAF to improve antiarrhythmia therapy.
Nedostup
A V
AV
Solov'eva
A D
AD
San'kova
T A
TA
D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy* / Q000523:psychology*; D001342:Autonomic Nervous System Diseases / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D001526:Behavioral Symptoms / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D002998:Clonazepam / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000927:Anticonvulsants; D002998:Clonazepam