title: Postoperative follow-up of anal condylomata acuminata in HIV-positive patients.
abstract: OBJECTIVE
  The purpose of this study was to analyze the postoperative follow-up of HIV-positive patients with anal condylomata acuminata, associating recurrence to the AIDS status.
  
  
  METHODS
  Ninety-seven male, homosexual patients with anal condylomata were submitted to surgical treatment from August 1992 to December 1997. Specimens were obtained for histologic investigation of Ki-67 cell proliferation marker and for polymerase chain reaction to define the human papillomavirus type. The patients were advised to return weekly during the first month, and monthly up to the sixth month, to evaluate recurrence. Patients with high-grade anal intraepithelial neoplasia remain in follow-up.
  
  
  RESULTS
  Histology revealed low-grade anal intraepithelial neoplasia in 81.44 percent of patients and high-grade lesions in 18.56 percent. The results showed that high-grade lesions were not more frequent in late-stage AIDS patients. Ki-67 expression, a cell proliferation marker, was greater in high-grade than in low-grade anal intraepithelial neoplasia, but had no association with AIDS status. Nononcogenic human papillomavirus 6 and 11 were the commonest types. Comparing papillomavirus types and anal intraepithelial grade, we noticed that both oncogenic and nononcogenic types were responsible for high-grade lesions. All patients healed and 51 (52.6 percent) had recurrence up to the sixth month. AIDS status and papillomavirus type were not associated with recurrence. However, high-grade anal intraepithelial neoplasia patients had more recurrence than those with low-grade lesions. Topical treatment failed in 20 patients (41.6 percent), and these were submitted to new surgical treatment. All of them were in the late stage of AIDS. Three who had high-grade lesions in the first operation had low-grade lesions in specimens from the second surgery. The same histologic pattern was observed in 17 patients who had low-grade lesions in warts removed in the first operation. Other patients with high-grade lesions had no recurrence or evolution to invasive carcinoma from five to ten years of follow-up.
  
  
  CONCLUSIONS
  High-grade anal intraepithelial neoplasia and late-stage AIDS are risk factors for recurrence of anal condylomata.
authors.affiliation: Department of Proctology, Emilio Ribas Infectious Diseases Institute, Sao Paulo, Brazil.
authors.forename: Carmen Ruth
authors.initials: CR
authors.lastname: Manzione
authors.forename: Sidney Roberto
authors.initials: SR
authors.lastname: Nadal
authors.forename: Edenilson Eduardo
authors.initials: EE
authors.lastname: Calore
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology; D000293:Adolescent; D000328:Adult; D001005:Anus Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery* / Q000821:virology; D003218:Condylomata Acuminata / Q000150:complications / Q000473:pathology / Q000601:surgery* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D005500:Follow-Up Studies; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics; D016133:Polymerase Chain Reaction; D012008:Recurrence
chemical_list: D004279:DNA, Viral; D019394:Ki-67 Antigen