Prenylated xanthones with NGF-potentiating activity from Garcinia xanthochymus.
Two prenylated xanthones, 1,4,5,6-tetrahydroxy-7,8-di(3-methylbut-2-enyl)xanthone (1) and 1,2,6-trihydroxy-5-methoxy-7-(3-methylbut-2-enyl)xanthone (2), were isolated from the wood of Garcinia xanthochymus along with a known xanthone, 12b-hydroxy-des-D-garcigerrin A (3). Their structures were elucidated by spectroscopic analysis. Compound 1 (10 muM), 2 (10-30 muM) and 3 (10 muM) showed a markedly enchancing activity of nerve growth factor (NGF)-mediated neurite outgrowth on PC12D cells.
Chanmahasathien
Wisinee
W
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
Li
Yushan
Y
Satake
Masayuki
M
Oshima
Yasukatsu
Y
Ruangrungsi
Nijsiri
N
Ohizumi
Yasushi
Y
D000818:Animals; D029760:Garcinia / Q000737:chemistry*; D008858:Microscopy, Phase-Contrast; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000378:metabolism*; D016501:Neurites / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D014934:Wood; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
D009414:Nerve Growth Factors; D044004:Xanthones; C009689:xanthone