title: Prenylated xanthones with NGF-potentiating activity from Garcinia xanthochymus.
abstract: Two prenylated xanthones, 1,4,5,6-tetrahydroxy-7,8-di(3-methylbut-2-enyl)xanthone (1) and 1,2,6-trihydroxy-5-methoxy-7-(3-methylbut-2-enyl)xanthone (2), were isolated from the wood of Garcinia xanthochymus along with a known xanthone, 12b-hydroxy-des-D-garcigerrin A (3). Their structures were elucidated by spectroscopic analysis. Compound 1 (10 muM), 2 (10-30 muM) and 3 (10 muM) showed a markedly enchancing activity of nerve growth factor (NGF)-mediated neurite outgrowth on PC12D cells.
authors.affiliation: Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
authors.forename: Wisinee
authors.initials: W
authors.lastname: Chanmahasathien
authors.forename: Yushan
authors.initials: Y
authors.lastname: Li
authors.forename: Masayuki
authors.initials: M
authors.lastname: Satake
authors.forename: Yasukatsu
authors.initials: Y
authors.lastname: Oshima
authors.forename: Nijsiri
authors.initials: N
authors.lastname: Ruangrungsi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohizumi
mesh_terms: D000818:Animals; D029760:Garcinia / Q000737:chemistry*; D008858:Microscopy, Phase-Contrast; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000378:metabolism*; D016501:Neurites / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D014934:Wood; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D009414:Nerve Growth Factors; D044004:Xanthones; C009689:xanthone