title: Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa.
abstract: Members of the Artemisia genus are important medicinal plants found throughout the world. Arteminolides A-D (1-4), isolated from the aerial parts of Artemisia, have an inhibitory activity on farnesyl-protein transferase (FPTase; EC 2.5.1.29) in in vitro assay. This study was carried out with the purpose of validating anti-tumor effects of the compounds in human tumor cells and mouse xenograft model. The arteminolides inhibited tumor cell growth in a dose-dependent manner. Furthermore, arteminolide C (3) blocked in vivo growth of human colon and lung tumor xenograft without the loss of body weight in nude mice.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, 52 Uendong Yoosunggu, Taejeon 305-600, South Korea.
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Lee
authors.forename: Mi-Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Hyun-Mi
authors.initials: HM
authors.lastname: Kang
authors.forename: Dong Cho
authors.initials: DC
authors.lastname: Han
authors.forename: Kwang-Hee
authors.initials: KH
authors.lastname: Son
authors.forename: Deok Cho
authors.initials: DC
authors.lastname: Yang
authors.forename: Nack-Do
authors.initials: ND
authors.lastname: Sung
authors.forename: Chang Woo
authors.initials: CW
authors.lastname: Lee
authors.forename: Hwan Mook
authors.initials: HM
authors.lastname: Kim
authors.forename: Byoung-Mog
authors.initials: BM
authors.lastname: Kwon
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D019306:Artemisia / Q000201:enzymology; D045744:Cell Line, Tumor; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D051231:Farnesyltranstransferase; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D008517:Phytotherapy; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D025521:Tumor Suppressor Proteins / Q000627:therapeutic use; D023041:Xenograft Model Antitumor Assays
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D007783:Lactones; D012717:Sesquiterpenes; D025521:Tumor Suppressor Proteins; C484914:arteminolide A; C484912:arteminolide B; C484913:arteminolide C; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase