title: Comparison of trichloroacetic acid solution and cryosurgery in the treatment of solar lentigines.
abstract: BACKGROUND
  Solar lentigines are benign keratinocytic proliferations resulting from prolonged and cumulative sun exposure. The newer photoselective lasers have become the mainstay of treatment. However, cryosurgery and trichloroacetic acid (TCA) solution are cost-effective alternatives in the treatment of solar lentigines.
  
  
  METHODS
  Twenty-five patients with multiple solar lentigines over the dorsa of their hands were included. Each hand was treated randomly with either 30% TCA solution or liquid nitrogen spray. The efficacy of treatment was evaluated at 8 weeks.
  
  
  RESULTS
  Cryosurgery was more likely to produce significant lightening of the lentigines than 30% TCA solution (P < 0.05) but was more painful and took longer to heal.
  
  
  CONCLUSIONS
  Cryosurgery was found to be superior to TCA 30% solution in the treatment of solar lentigines. This study demonstrates that old-fashioned treatments for solar lentigines are still excellent and cost-effective therapeutic choices.
authors.affiliation: Department of Dermatology, University of Puerto Rico, School of Medicine, San Juan, Puerto Rico. alexlugo14@msn.com
authors.forename: Alexander
authors.initials: A
authors.lastname: Lugo-Janer
authors.forename: Aida
authors.initials: A
authors.lastname: Lugo-Somolinos
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Sanchez
mesh_terms: D002424:Caustics / Q000627:therapeutic use*; D003452:Cryosurgery / Q000009:adverse effects; D005260:Female; D006229:Hand Dermatoses / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007911:Lentigo / Q000209:etiology / Q000628:therapy*; D010146:Pain / Q000209:etiology; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014238:Trichloroacetic Acid / Q000627:therapeutic use*; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014945:Wound Healing
chemical_list: D002424:Caustics; D014238:Trichloroacetic Acid