[The remyelination phenomenon in multiple sclerosis].
Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system. Available treatments (immuno-modulators, immuno-suppressants) limit central nervous system inflammation and are only partially effective. Remyelination of naked axons becomes insufficient in most cases as the disease progresses. The reason for this repair deficit are many, including oligodendroglial, axonal and environmental factors. Understanding why remyelination fails is crucial for devising effective methods by which to enhance it.
Lubetzki
Catherine
C
Fédération de Neurologie et INSERM U-495, Groupe Hospitalier Pitié-Salpêtrière-47-83, Boulevard de l'Hôpital-75651 Paris.
D000818:Animals; D001253:Astrocytes / Q000502:physiology; D001369:Axons / Q000648:ultrastructure; D004195:Disease Models, Animal; D006133:Growth Substances / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D008264:Macrophages / Q000502:physiology; D009103:Multiple Sclerosis / Q000188:drug therapy / Q000503:physiopathology*; D009186:Myelin Sheath / Q000502:physiology*; D009836:Oligodendroglia / Q000502:physiology
D006133:Growth Substances