A functional genetic variation of the 5-HT2a receptor affects human memory.
Human memory capacity is highly variable across individuals and is influenced by both genetic and environmental factors. A roughly 50% heritability estimate indicates that naturally occurring genetic variations have an important impact on this cognitive ability. Therefore, we investigated a functional variation of a memory-related serotonin receptor in 349 healthy young volunteers, and found 21% poorer memory performance in subjects with the rare variant.
de Quervain
Dominique J-F
DJ
Division of Psychiatry Research, University of Zürich, Lenggstr. 31, 8029 Zürich, Switzerland. quervain@bli.unizh.ch
Henke
Katharina
K
Aerni
Amanda
A
Coluccia
Daniel
D
Wollmer
M Axel
MA
Hock
Christoph
C
Nitsch
Roger M
RM
Papassotiropoulos
Andreas
A
D016022:Case-Control Studies; D014644:Genetic Variation; D005838:Genotype; D006639:Histidine / Q000235:genetics; D008568:Memory / Q000502:physiology*; D009154:Mutation; D011110:Polymorphism, Genetic; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics / Q000502:physiology*; D014443:Tyrosine / Q000235:genetics; D014706:Verbal Learning
D044402:Receptor, Serotonin, 5-HT2A; D014443:Tyrosine; D006639:Histidine