title: [Influence of drugs administered in general anesthesia and in pre- and post-operative periods on transiently evoked otoacoustic emissions (TEOAE) in children operated for congenital heart defects (part II)].
abstract: Outer hair cells are believed to be responsible for generation of otoacoustic emissions (OAEs). High sensitivity of OAE makes it possible to diagnose subclinical cochlear pathologies even if they have not yet been revealed by tonal audiometry. The aim of this study was to evaluate an influence of general anesthesia and other drugs administered in pre- and post-operative period on TEOAE in subjects operated on for various congenital heart defects in extracorporeal circulation. The investigated group consisted of 44 children with no pathology confirmed during ENT examination, in age ranging from 6 months to 19 years (average 9.3 years; +/- 5.9 years). The control group consisted of 14 otologically and cardiologically healthy subjects aged from 2-16 years (average 10.3 +/- 3.4 years). In the investigated group, TEOAEs were measured twice: one day before and 7-8 days following surgery. In the control group, TEOAEs were recorded in the same manner. Statistical analysis revealed no significant differences in the control group, between second and first TEOAE tests. Analysis of the influence of the drugs administered in general anesthesia did not show significant influence on post-operative TEOAEs. Among ototoxic drugs only acetylsalicylic acid affected TEOAE in post-operative tests. The authors conclude that general anaesthesia does not change the cochlear function, although, in children in whom acetylsalicylic acid was administered in post-operative period the cochlear function was affected. In these subjects the function of the cochlea should be monitored in post-surgical period.
authors.affiliation: II Klinika i Katedra Slaskiej AM w Zabrzu.
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Morawski
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Namysłowski
authors.forename: Irena
authors.initials: I
authors.lastname: Urban
authors.forename: Grazyna
authors.initials: G
authors.lastname: Lisowska
authors.forename: Janusz
authors.initials: J
authors.lastname: Skalski
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D000768:Anesthesia, General / Q000009:adverse effects; D018681:Anesthetics, General / Q000009:adverse effects*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003051:Cochlea / Q000187:drug effects*; D005112:Extracorporeal Circulation / Q000379:methods; D005260:Female; D006330:Heart Defects, Congenital / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D017084:Otoacoustic Emissions, Spontaneous / Q000187:drug effects*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D018681:Anesthetics, General