Ganglioside GM1 mimics: lipophilic substituents improve affinity for cholera toxin.
Ganglioside GM1 mimics including (R)-2-hydroxy-3-cyclohexylpropionic acid or (R)-2-hydroxy-3-phenylpropionic acid as replacements for NeuAc are stronger cholera toxin binders than the parent ligand 2, which includes (R)-2-hydroxy-propionic acid.
Arosio
Daniela
D
Dipartimento di Chimica Organica e Industriale, Universita' di Milano, via Venezian 21, 20133 Milan, Italy.
Baretti
Sergio
S
Cattaldo
Stefania
S
Potenza
Donatella
D
Bernardi
Anna
A
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002772:Cholera Toxin / Q000737:chemistry*; D005677:G(M1) Ganglioside / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D018716:Molecular Mimicry; D008969:Molecular Sequence Data
D005677:G(M1) Ganglioside; D002772:Cholera Toxin