Palladium-catalyzed negishi cross-coupling reactions of unactivated alkyl iodides, bromides, chlorides, and tosylates.
A single method (2% Pd(2)(dba)(3)/8% PCyp(3)/NMI in THF/NMP at 80 degrees C; Cyp = cyclopentyl) achieves the cross-coupling of a range of beta-hydrogen-containing primary alkyl iodides, bromides, chlorides, and tosylates with an array of alkyl-, alkenyl-, and arylzinc halides. The process is compatible with a variety of functional groups, including esters, amides, imides, nitriles, and heterocycles.
Zhou
Jianrong
J
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Fu
Gregory C
GC
D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D014105:Tosyl Compounds / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry
D006846:Hydrocarbons, Halogenated; D009942:Organometallic Compounds; D014105:Tosyl Compounds; D010165:Palladium; D015032:Zinc