Endoglin (CD105): a powerful therapeutic target on tumor-associated angiogenetic blood vessels.
Among surface molecules expressed on endothelial cells, endoglin (CD105) is emerging as a prime vascular target for antiangiogenetic cancer therapy. CD105 is a cell membrane glycoprotein mainly expressed on endothelial cells and overexpressed on tumor-associated vascular endothelium, which functions as an accessory component of the transforming growth factor -beta receptor complex and is involved in vascular development and remodelling. Quantification of intratumoral microvessel density by CD105 staining and of circulating soluble CD105 has been suggested to have prognostic significance in selected neoplasias. In addition, the potential usefulness of CD105 in tumor imaging and antiangiogenetic therapy has been well documented utilizing different animal models.
Fonsatti
Ester
E
Cancer Bioimmunotherapy Unit, Department of Medical Oncology, Centro di Riferimento Oncologico, Istituto di Ricovero e Cura a Carattere Scientific, Aviano 33081, Italy.
Altomonte
Maresa
M
Nicotra
Maria Rita
MR
Natali
Pier Giorgio
PG
Maio
Michele
M
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D015703:Antigens, CD; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D018450:Disease Progression; D000071063:Endoglin; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D011956:Receptors, Cell Surface; D019010:Vascular Cell Adhesion Molecule-1 / Q000187:drug effects / Q000235:genetics / Q000502:physiology*
D020533:Angiogenesis Inhibitors; D015703:Antigens, CD; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; D019010:Vascular Cell Adhesion Molecule-1