title: Neuronal and muscular alterations caused by two wheat endosperm proteins, puroindoline-a and alpha1-purothionin, are due to ion pore formation.
abstract: Using the patch-clamp technique it was found that the toxicity of the two wheat endosperm proteins puroindoline-a and alpha1-purothionin probably results from the dissipation of ion concentration gradients essential for the maintenance of cellular homeostasis.
authors.affiliation: Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Independencia No. 1027, Casilla 70005, Santiago 6530499, Chile.
authors.forename: Paola
authors.initials: P
authors.lastname: Llanos
authors.forename: Mauricio
authors.initials: M
authors.lastname: Henriquez
authors.forename: Jasmina
authors.initials: J
authors.lastname: Minic
authors.forename: Khalil
authors.initials: K
authors.lastname: Elmorjani
authors.forename: Didier
authors.initials: D
authors.lastname: Marion
authors.forename: Gloria
authors.initials: G
authors.lastname: Riquelme
authors.forename: Jordi
authors.initials: J
authors.lastname: Molgó
authors.forename: Evelyne
authors.initials: E
authors.lastname: Benoit
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006706:Homeostasis; D008081:Liposomes / Q000737:chemistry; D051379:Mice; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D009469:Neuromuscular Junction; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018408:Patch-Clamp Techniques; D010940:Plant Proteins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D018272:Porins / Q000378:metabolism*; D016062:Porosity
chemical_list: D023181:Antimicrobial Cationic Peptides; D008081:Liposomes; D010940:Plant Proteins; D018272:Porins; C082942:puroindoline protein, Triticum aestivum; C063948:alpha1-purothionin protein, wheat