title: Molecular genetic analysis of the virulence of oral bacterial pathogens: an historical perspective.
abstract: This review will focus on the impact of molecular genetic approaches on elucidating the bacterial etiology of oral diseases from an historical perspective. Relevant results from the pre- and post-recombinant DNA periods will be highlighted, including the roles of gene cloning, mutagenesis, and nucleotide sequencing in this area of research. Finally, the impact of whole-genome sequencing on deciphering the virulence mechanisms of oral pathogens, along with new approaches to control these organisms, will be discussed.
authors.affiliation: Department of Oral Biology, State University of New York, Buffalo, NY 14214, USA. kuramits@buffalo.edu
authors.forename: Howard K
authors.initials: HK
authors.lastname: Kuramitsu
mesh_terms: D016976:Aggregatibacter actinomycetemcomitans / Q000235:genetics / Q000472:pathogenicity; D000818:Animals; D003731:Dental Caries / Q000382:microbiology*; D005821:Genetic Techniques / Q000266:history; D016680:Genome, Bacterial; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008967:Molecular Biology / Q000266:history; D010510:Periodontal Diseases / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000235:genetics / Q000472:pathogenicity; D013295:Streptococcus mutans / Q000235:genetics / Q000472:pathogenicity; D037521:Virulence Factors / Q000235:genetics
chemical_list: D037521:Virulence Factors