title: Media for hybridoma growth and monoclonal antibody production.
abstract: For the economical production of monoclonal antibodies (MAbs), the cell-culture medium must be optimized for three different phases: growth of the hybridomas, MAb productivity of the hybridomas, and MAb purification or downstream processing. Medium improvements are necessary to meet these requirements for large-scale MAb production. Information bearing on this issue is being addressed in two research areas, cell biology and biochemical engineering, and is reviewed in this article.
authors.affiliation: Department of Biology, University of Waterloo, Waterloo, Ontario, N2L 2G1, Canada.
authors.forename: N C
authors.initials: NC
authors.lastname: Bols
authors.forename: J M
authors.initials: JM
authors.lastname: Scharer
authors.forename: H A
authors.initials: HA
authors.lastname: Phillips
authors.forename: M
authors.initials: M
authors.lastname: Moo-Young