Synthesis and cytotoxic activity of some new azapyranoxanthenone aminoderivatives.
A series of novel azapyranoxanthenones, bearing structural similarity to the acridone alkaloid acronycine have been designed and synthesized. Their in vitro cytotoxicities against the murine L1210 leukemia and the human solid tumor HT-29 cell lines have been investigated. The new derivatives exhibited interesting cytotoxic activity and were more potent than the parent compound.
Kolokythas
George
G
Division of Pharmaceutical Chemistry, Department of Pharmacy, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.
Kostakis
Ioannis K
IK
Pouli
Nicole
N
Marakos
Panagiotis
P
Kletsas
Dimitris
D
Pratsinis
Harris
H
D000166:Acridines / Q000737:chemistry; D054831:Acridones; D000175:Acronine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D018797:Cell Cycle Proteins / Q000032:analysis; D045744:Cell Line, Tumor; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice
D000166:Acridines; D054831:Acridones; D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins; C041300:acridone; D000175:Acronine