title: Acute fatal poisoning with cyamemazine.
abstract: A case of fatal poisoning with cyamemazine is presented. The cyamemazine was identified in post-mortem blood using a specific gas chromatographic/mass spectrometry method. The autopsy blood concentration of cyamemazine was 1800 ng/ml. Chronic use of cyamemazine was demonstrated by the presence of the drug in hair. Two other drugs were also detected (bromazepam and trimeprazine). We think that this current blood concentration (1800 ng/ml) is a fatal blood concentration because of the negativity of the other parameters, but careful interpretation of analytical findings are important, the possibility that this death was a consequence of the toxicity of combined drugs could not be excluded. Not many therapeutics and toxic levels were previously reported in overdosage cases in which cyamemazine was involved. We consider that this concentration is only of guidance value for a fatal cyamemazine poisoning.
authors.affiliation: Laboratoire de Médecine Légale et Anthropologie Medico-Légale, Faculte de Médecine, Avenue de Valombrose, 06107 Nice Cedex 2, France. alunni-perret.v@chu-nice.fr
authors.forename: V
authors.initials: V
authors.lastname: Alunni-Perret
authors.forename: P
authors.initials: P
authors.lastname: Ohayon
authors.forename: H P
authors.initials: HP
authors.lastname: Duval
authors.forename: G
authors.initials: G
authors.lastname: Quatrehomme
mesh_terms: D014151:Anti-Anxiety Agents / Q000032:analysis; D000982:Antipruritics / Q000032:analysis; D014150:Antipsychotic Agents / Q000032:analysis / Q000506:poisoning*; D001960:Bromazepam / Q000032:analysis; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006197:Hair / Q000737:chemistry; D006801:Humans; D008875:Middle Aged; D010640:Phenothiazines / Q000032:analysis / Q000506:poisoning*; D014291:Trimeprazine / Q000032:analysis
chemical_list: D014151:Anti-Anxiety Agents; D000982:Antipruritics; D014150:Antipsychotic Agents; D010640:Phenothiazines; D014291:Trimeprazine; C028457:cyamemazine; D001960:Bromazepam