Synthesis and properties of halogenated 7-deaza-2'-deoxyxanthosine and protected derivatives for oligonucleotide synthesis.
The 7-bromo- (4a) and 7-iodo- (4b) derivatives of 7-deaza-2'-deoxyxanthosine (5) are prepared. Furthermore, the building blocks 6-8 of 7-deaza-2'-deoxyxanthosine (5) are synthesized and tested for their usage in oligonucleotide synthesis.
Seela
F
F
Laboratorium für Organische und Bioorganische Chemie, Institut für Chemie, Universität Osnabrück, Osnabrück, Germany. frank.seela@uni-osnabrueck.de
Shaikh
K
K
Wiglenda
T
T
D003853:Deoxyribonucleosides / Q000138:chemical synthesis / Q000737:chemistry; D006027:Glycosides; D007202:Indicators and Reagents; D015394:Molecular Structure; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
C079959:7-deaza-2'-deoxyxanthosine; D003853:Deoxyribonucleosides; D006027:Glycosides; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides