Antimicrobial studies of hydrazone complexes of Hg(II) and Fe(II) divalent metal ions.
The antibacterial, antifungal and antitubercular activities of Hg(II) and Fe(II) complexes of hydrazone were studied. All the complexes have been screened against Staphylococcus aureus, Salmonella typhi, Candida albicans, Aspergillus niger, Saccharomyces cerevisiae and Mycobacterium tuberculosis H37Rv and found to be more toxic than the parent ligand. The activity increased in the order [5-methyl-3-oximino-hexan-2-one-hydrazone]2 Fe(II) < [5-methyl-3-oximino-hexan-2-one-hydrazone]2 Hg(II) < 3-oximino-hexan-2-one-phenylhydrazone]2 Fe(II) < [5-methyl-3-oximino-hexan-2-one-phenylhydrazone]2 Hg(II) for antibacterial and antifungal activity.
Donde
K J
KJ
Department of Chemistry, Institute of Science, 15, Madam Cama Road, Mumbai-400 032, India.
Patil
V R
VR
Malve
S P
SP
D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006835:Hydrazones / Q000737:chemistry / Q000494:pharmacology*; D058085:Iron Compounds / Q000737:chemistry / Q000494:pharmacology*; D017669:Mercury Compounds / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000890:Anti-Infective Agents; D006835:Hydrazones; D058085:Iron Compounds; D017669:Mercury Compounds