Chemokines and cytokines: axis and allies in asthma and allergy.
Allergic asthma can be precipitated by many factors. For the atopic person, fungus, pollen, dust mites, cockroach antigens, and diesel exhaust are all agents that may trigger an allergic attack. Cytokines and chemokines are integral mediators of fungal asthma. From the earliest time points, they recruit and activate the cells required for the clearance of fungus as well as being critical factors involved in the immunopathology of this disease. In the final analysis, it is clear that these mediators can act to the benefit or the detriment of the host.
Schuh
Jane M
JM
Department of Pathology, University of Michigan Medical School, Medical Science I, Room 5214, 1301 Catherine Road, Ann Arbor, MI 48109-0602, USA. janeschu@umich.edu
Blease
Kate
K
Kunkel
Steven L
SL
Hogaboam
Cory M
CM
D000818:Animals; D001232:Aspergillus fumigatus / Q000378:metabolism; D001249:Asthma / Q000378:metabolism* / Q000382:microbiology; D018925:Chemokines / Q000502:physiology*; D016207:Cytokines / Q000378:metabolism / Q000502:physiology*; D005656:Fungal Proteins / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000378:metabolism* / Q000382:microbiology; D008168:Lung / Q000276:immunology; D008954:Models, Biological; D010587:Phagocytosis; D018418:Th2 Cells / Q000378:metabolism
D018925:Chemokines; D016207:Cytokines; D005656:Fungal Proteins