A facile synthetic method for 3'-alpha-fluoro-2',3'-dideoxyadenosine.
A facile method for the synthesis of 3'-alpha-fluoro-2',3'-dideoxyadenosine (5) has been developed using a novel rearrangement of 3'-beta-bromine to the 2'-beta position during 3'-alpha fluorination.
Takamatsu
Satoshi
S
AminoScience Laboratories, Ajinomoto Co., Inc., Kawasaki-ku, Kawasaki, Japan. satoshi-takamatsu@ajinomoto.com
Katayama
Satoshi
S
Naito
Masaki
M
Yamashita
Keizo
K
Ineyama
Takashi
T
Izawa
Kunisuke
K
D019380:Anti-HIV Agents / Q000138:chemical synthesis; D016048:Dideoxyadenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D013237:Stereoisomerism
D019380:Anti-HIV Agents; D007202:Indicators and Reagents; C073072:lodenosine; D016048:Dideoxyadenosine