Successful DTPA therapy in the case of 239Pu penetration via injured skin exposed to nitric acid.
This paper presents results of the radiological study and DTPA therapy for a worker exposed to a plutonium nitrate solution. Plutonium levels were measured in excreta, blood, plasma and wound for several weeks. Plutonium renal clearance ranged from 110-190 ml min(-1) to 3-4 ml min(-1) at different stages of chelation therapy. Plutonium absorption into blood from the injured skin amounted to 4.3%. As a result of intensive therapy, 96% of absorbed plutonium was successfully excreted.
Khokhryakov
V F
VF
Southern Ural Biophysics Institute, Ozyorsk Road, 19, Ozyorsk Chelyabinsk Region 456780, Russia. khokhryakov@lab3.fib.ozersk.ru
Belyaev
A P
AP
Kudryavtseva
T I
TI
Schadilov
A E
AE
Moroz
G S
GS
Shalaginov
V A
VA
D000287:Administration, Topical; D002057:Burns, Chemical / Q000150:complications / Q000188:drug therapy*; D002614:Chelating Agents / Q000008:administration & dosage; D015913:Chelation Therapy / Q000379:methods*; D003666:Decontamination / Q000379:methods*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009566:Nitrates / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity* / Q000652:urine; D016273:Occupational Exposure / Q000032:analysis / Q000517:prevention & control; D004369:Pentetic Acid / Q000008:administration & dosage*; D011005:Plutonium / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity* / Q000652:urine; D011832:Radiation Injuries / Q000188:drug therapy* / Q000209:etiology; D011835:Radiation Protection / Q000379:methods*; D018788:Radioactive Hazard Release; D012867:Skin / Q000187:drug effects / Q000293:injuries / Q000528:radiation effects; D016896:Treatment Outcome; D014915:Whole-Body Counting / Q000379:methods
D002614:Chelating Agents; D009566:Nitrates; C015459:plutonium nitrate; D011005:Plutonium; D004369:Pentetic Acid