title: Comparison study of oxygen-induced MRI-signal changes and pO2 changes in murine tumors.
abstract: The purpose of this study was to compare the results from oxygen-induced MR-signal intensity changes with polarographic pO2 measurements in tumors. Balb-c mice with an intramuscular transplanted osteosarcoma were examined. To study the response of tumors to changes in oxygen supply, hyperoxia was induced by breathing pure oxygen for a short period. The examination of each animal started with T2* weighted MRI followed by the pO2 measurements (Eppendorf Histograph). During oxygen inhalation in all tumors, when the hypoxic tumor fraction drops, both areas of significant MR-signal intensity increase and decrease were observed in each animal.
authors.affiliation: Dept. of Radiation Oncology, Klinikum rechts der Isar, TU Munich, Germany.
authors.forename: Lothar
authors.initials: L
authors.lastname: Weissfloch
authors.forename: Michael
authors.initials: M
authors.lastname: Peller
authors.forename: Juergen
authors.initials: J
authors.lastname: Weber
authors.forename: Hans-Juergen
authors.initials: HJ
authors.lastname: Feldmann
authors.forename: Reingart
authors.initials: R
authors.lastname: Senekowitsch-Schmidtke
authors.forename: Karlheinz
authors.initials: K
authors.lastname: Tempel
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Coderre
authors.forename: Michael
authors.initials: M
authors.lastname: Molls
authors.forename: Michael
authors.initials: M
authors.lastname: Reiser
mesh_terms: D000818:Animals; D008279:Magnetic Resonance Imaging; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism*; D012516:Osteosarcoma / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*
chemical_list: D010100:Oxygen