title: [Cholestatic hepatitis caused by prajmalium treatment: case report].
abstract: Prajmalium rarely causes idiosyncratic liver injury. Author describes the case of cholestatic hepatitis occurring in three weeks after cessation of short-term treatment with prajmalium. Eighteen months later, despite of good general status, physical and biochemical features of cholestasis were present. Pathologic examination of liver biopsy specimen revealed the chronic intracellular cholestasis with lymphocytic infiltration. Presented case indicate that even short-term treatment with potentially weekly hepatotoxic drug may cause the long-term intrahepatic cholestasis.
authors.affiliation: Katedra i Klinika Chorób Zakaźnych i Hepatologii Uniwersytetu Medycznego w Łodzi.
authors.forename: Anna
authors.initials: A
authors.lastname: Piekarska
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications* / Q000209:etiology*; D002780:Cholestasis, Intrahepatic / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011219:Prajmaline / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000889:Anti-Arrhythmia Agents; D011219:Prajmaline