[Impaired balance of the lung proteolytic system in patients with pneumoconiosis and chronic dust-induced bronchitis].
The activity of neutrophilic elastase and the level of its major inhibitor--an alpha 1-inhibitor of proteinases were studied to evaluate the protease-antiprotease system in the bronchoalveolar lavage fluid (BALF) of patients with chronic dust-induced bronchitis (CDB) and pneumoconiosis (PC). It was found that CDB, as compared with PC, was characterized by a higher elastase activity in the BALF (70%) and that there were a larger number of patients with elastase activity (40%), which correlated with the detection rate of emphysema. Free elastase activity and relative proteinase alpha 1-inhibitor deficiency suggest that the BALF protease-antiprotease system is impaired in patients with CDB and PC, which is more pronounced in patients with CDB.
Surkova
E A
EA
Orlova
G P
GP
Ses'
T P
TP
D029481:Bronchitis, Chronic / Q000201:enzymology* / Q000209:etiology; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D004391:Dust; D005260:Female; D006801:Humans; D019272:Leukocyte Elastase / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011009:Pneumoconiosis / Q000201:enzymology* / Q000209:etiology; D011480:Protease Inhibitors / Q000378:metabolism*
D004391:Dust; D011480:Protease Inhibitors; D019272:Leukocyte Elastase