title: Correlation between the early morphological appearance of filtering blebs and outcome of trabeculectomy with mitomycin C.
abstract: OBJECTIVE
  To correlate the morphologic appearance of filtering blebs in the early postoperative period with the outcome of trabeculectomy with mitomycin C (MMC) during the first postoperative year.
  
  
  METHODS
  In a prospective study, the morphologic appearance of filtering blebs after primary trabeculectomy with adjunctive MMC (0.1 mg/ml for 5 minutes intra-operatively) was classified; 49 eyes of 49 patients were examined preoperatively, 1 and 3 days, 1 and 2 weeks, 1, 3, 6, and 12 months postoperatively. Status of filtering bleb, intraocular pressure (IOP), and number of medications were recorded.
  
  
  RESULTS
  One year after surgery all patients had IOP < or = 21; 6 patients received antiglaucoma medication. One eye required needling of the filtering bleb because of encapsulation. During the first postoperative year, eyes with conjunctival subepithelial micro cysts, observed in the first and the second postoperative week, had significantly lower mean IOP, than eyes without (11.1 mm Hg vs. 13.9 mm Hg; p:0.0043, ANOVA). Eyes with corkscrew vessels, observed in the first and the second postoperative week, had significantly higher mean IOP, than eyes without during the first postoperative year (13.4 mm Hg vs. 11.7 mm Hg; p:0.0141, ANOVA).
  
  
  CONCLUSIONS
  Classification of filtering blebs after trabeculectomy with MMC may help to disclose patients with an increased failure risk.
authors.affiliation: Department of Ophthalmology, University of Vienna Medical School, Vienna, Austria.
authors.forename: Stefan
authors.initials: S
authors.lastname: Sacu
authors.forename: Georg
authors.initials: G
authors.lastname: Rainer
authors.forename: Oliver
authors.initials: O
authors.lastname: Findl
authors.forename: Michael
authors.initials: M
authors.lastname: Georgopoulos
authors.forename: Clemens
authors.initials: C
authors.lastname: Vass
mesh_terms: D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003228:Conjunctiva / Q000098:blood supply / Q000473:pathology*; D017889:Exfoliation Syndrome / Q000601:surgery; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use*; D011446:Prospective Studies; D014130:Trabeculectomy; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin