Evaluation of a continuous glucose monitoring system for use in dogs, cats, and horses.
OBJECTIVE
To evaluate a continuous glucose monitoring system (CGMS) for use in dogs, cats, and horses.


METHODS
Prospective clinical study. Animals-7 horses, 3 cats, and 4 dogs that were clinically normal and 1 horse, 2 cats, and 3 dogs with diabetes mellitus.


METHODS
Interstitial glucose concentrations were monitored and recorded every 5 minutes by use of a CGMS. Interstitial glucose concentrations were compared with whole blood glucose concentrations as determined by a point-of-care glucose meter. Interstitial glucose concentrations were also monitored in 2 clinically normal horses after oral and i.v. administration of glucose.


RESULTS
There was a positive correlation between interstitial and whole blood glucose concentrations for clinically normal dogs, cats, and horses and those with diabetes mellitus. Events such as feeding, glucose or insulin administration, restraint, and transport to the clinic were recorded by the owner or clinician and could be identified on the graph and associated with time of occurrence.


CONCLUSIONS
Our data indicate that use of CGMS is valid for dogs, cats, and horses. This system alleviated the need for multiple blood samples and the stress associated with obtaining those samples. Because hospitalization was not required, information obtained from the CGMS provided a more accurate assessment of the animal's glucose concentrations for an extended period, compared with measurement of blood glucose concentrations. Use of the CGMS will promote the diagnostic and research potential of serial glucose monitoring.
Wiedmeyer
Charles E
CE
Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA.
Johnson
Philip J
PJ
Cohn
Leah A
LA
Meadows
Richard L
RL
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D002371:Cat Diseases / Q000097:blood* / Q000175:diagnosis; D002415:Cats; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood* / Q000175:diagnosis; D004285:Dogs; D006734:Horse Diseases / Q000097:blood* / Q000175:diagnosis; D006736:Horses; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000662:veterinary; D011446:Prospective Studies; D012680:Sensitivity and Specificity
D001786:Blood Glucose