title: Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult mice.
abstract: Neonatal exposure to polybrominated diphenyl ether (PBDE 153) disrupts spontaneous behaviour, impairs learning and memory, and decreases hippocampal cholinergic receptors in adult mice. Flame retardants are used to suppress or inhibit combustion processes in an effort to reduce the risk of fire. One class of flame retardants, polybrominated diphenyl ethers (PBDEs), are present and increasing in the environment and in human milk. The present study shows that neonatal exposure to 2,2',4,4',5,5'-hexaBDE (PBDE 153), a PBDE persistent both in environment and in human milk, can induce developmental neurotoxic effects, such as changes in spontaneous behaviour (hyperactivity), impairments in learning and memory, and reduced amounts of nicotinic receptors, effects that get worse with age. Neonatal NMRI male mice were orally exposed on day 10 to 0.45, 0.9, or 9.0 mg of PBDE 153/kg of body weight. Spontaneous behaviour (locomotion, rearing, and total activity) was observed in 2-, 4-, and 6-month-old mice, Morris water maze at an age of 6 months. The behaviour tests showed that the effects were dose-response and time-response related. Animals showing defects in learning and memory also showed significantly reduced amounts of nicotinic receptors in hippocampus, using alpha-bungarotoxin binding assay. The observed developmental neurotoxic effects seen for PBDE 153 are similar to those seen for PBDE 99 and for certain PCBs. Furthermore, PBDEs appear to as potent as the PCBs.
authors.affiliation: Department of Environmental Toxicology, Uppsala University, Norbyvägen 18A, S-75236 Uppsala, Sweden. Henrik.Viberg@ebc.uu.se
authors.forename: Henrik
authors.initials: H
authors.lastname: Viberg
authors.forename: Anders
authors.initials: A
authors.lastname: Fredriksson
authors.forename: Per
authors.initials: P
authors.lastname: Eriksson
mesh_terms: D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001665:Binding Sites; D004305:Dose-Response Relationship, Drug; D005260:Female; D005411:Flame Retardants / Q000633:toxicity*; D055768:Halogenated Diphenyl Ethers; D006624:Hippocampus / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls / Q000633:toxicity*; D011978:Receptors, Nicotinic / Q000096:biosynthesis*; D013550:Swimming
chemical_list: D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers; D010647:Phenyl Ethers; D011075:Polybrominated Biphenyls; D011978:Receptors, Nicotinic; C478854:2,2',4,4',5,5'-hexabrominated diphenyl ether