Xenotransplantation of embryonic precursors of human myogenesis for the correction of dystrophinopathy in mice with hereditary muscular dystrophy.
Human embryonic myogenic precursors were transplanted into muscles of mdx mice with hereditary dystrophin-deficient muscular dystrophy. Transplantation induced the synthesis of human dystrophin. The number of dystrophin-positive fibers progressively decreased, however, some of them were preserved even 5 months after transplantation. Our results indicate that xenogeneic transplantation of embryonic myogenic precursors compensates the genetic defect in dystrophin-deficient mice.
Yarygin
V N
VN
Russian State Medical University, Moscow.
Sukhikh
G T
GT
Sitnikov
V F
VF
Stenina
M A
MA
Kuznetsov
A B
AB
Poltavtseva
R A
RA
Krivov
L I
LI
Voevodin
D A
DA
Savchuk
V I
VI
Revishchin
A V
AV
Korochkin
L I
LI
Aleksandrova
M A
MA
D000818:Animals; D017690:Cell Transplantation; D004247:DNA / Q000378:metabolism; D004195:Disease Models, Animal; D016189:Dystrophin / Q000235:genetics / Q000378:metabolism; D004622:Embryo, Mammalian / Q000166:cytology*; D005091:Exons; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D018101:Mice, Inbred mdx; D009132:Muscles / Q000166:cytology*; D009136:Muscular Dystrophies / Q000235:genetics / Q000473:pathology*; D009137:Muscular Dystrophy, Animal / Q000235:genetics / Q000473:pathology*; D009154:Mutation; D016133:Polymerase Chain Reaction; D013997:Time Factors; D014183:Transplantation, Heterologous
D016189:Dystrophin; D004247:DNA