A neural mechanism for sudden death after myocardial infarction.
By monitoring efferent cardiac sympathetic nerve activity (CSNA) directly in a conscious animal we observed, for the first time, that ventricular fibrillation (VF) following myocardial infarction (MI) was preceded by a paroxysm of CSNA which was not baroreflexmodulated. This observation has potential therapeutic implications.
Jardine
D L
DL
Charles
C J
CJ
Forrester
M D E
MD
Whitehead
M
M
Nicholls
M G
MG
D000818:Animals; D001794:Blood Pressure; D016757:Death, Sudden, Cardiac; D005260:Female; D006321:Heart / Q000294:innervation*; D006339:Heart Rate; D009203:Myocardial Infarction / Q000503:physiopathology*; D012756:Sheep; D013564:Sympathetic Nervous System / Q000503:physiopathology*