title: Protein surface recognition by rational design: nanomolar ligands for potassium channels.
abstract: The rational design and development of four-fold symmetrical ligands for potassium channels is described.
authors.affiliation: Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, Berkeley, California 94720-1460, USA. trauner@cchem.berkeley.edu
authors.forename: Stefan N
authors.initials: SN
authors.lastname: Gradl
authors.forename: John P
authors.initials: JP
authors.lastname: Felix
authors.forename: Ehud Y
authors.initials: EY
authors.lastname: Isacoff
authors.forename: Maria L
authors.initials: ML
authors.lastname: Garcia
authors.forename: Dirk
authors.initials: D
authors.lastname: Trauner
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D001667:Binding, Competitive; D007700:Kinetics; D008024:Ligands; D008969:Molecular Sequence Data; D011166:Porphyrins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D026902:Potassium Channel Blockers / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D015221:Potassium Channels / Q000737:chemistry* / Q000378:metabolism; D051637:Shaker Superfamily of Potassium Channels; D013499:Surface Properties; D014981:Xenopus
chemical_list: D001426:Bacterial Proteins; D008024:Ligands; D011166:Porphyrins; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D051637:Shaker Superfamily of Potassium Channels; C107790:prokaryotic potassium channel