Increase in error threshold for quasispecies by heterogeneous replication accuracy.
In this paper we investigate the error threshold for quasispecies with heterogeneous replication accuracy. We show that the coexistence of error-free and error-prone polymerases can greatly increase the error threshold without a catastrophic loss of genetic information. We also show that the error threshold is influenced by the number of replicores. Our research suggests that quasispecies with heterogeneous replication accuracy can reduce the genetic cost of selective evolution while still producing a variety of mutants.
Aoki
Kazuhiro
K
White-Bird Institute, 1-14-9 Hanabatake, Tsukuba, Ibaraki 300-3261, Japan.
Furusawa
Mitsuru
M
D004247:DNA / Q000737:chemistry*; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D016680:Genome, Bacterial; D008957:Models, Genetic; D015233:Models, Statistical; D009154:Mutation; D013045:Species Specificity
D004247:DNA; D004259:DNA-Directed DNA Polymerase