title: Electrophysiological studies of the effects of 5,6-dihydroxytryptamine on the acquisition of a conditioned defensive reflex in snails.
abstract: The role of serotonin in the membrane properties of identified neurons was studied during acquisition of a conditioned defensive reflex. Serotonin deficiency was created using the neurotoxic serotonin analog 5,6-dihydroxytryptamine (5,6-DHT). Injection of 5,6-DHT was found to prevent decreases in the membrane and threshold potentials of command neurons during acquisition of the conditioned reflex as compared with snails given 5,6-DHT without training. Common snails recovered the ability to acquire the conditioned reflex two weeks after a second 5,6-DHT injection.
authors.affiliation: Biophysics Laboratory, Kazan' Physical-Technical Institute, Russian Academy of Sciences, 10/7 Sibirskii Trakt, 420029 Kazan'-29, Russia.
authors.forename: T Kh
authors.initials: TKh
authors.lastname: Gainutdinova
authors.forename: V V
authors.initials: VV
authors.lastname: Andrianov
authors.forename: Kh L
authors.initials: KhL
authors.lastname: Gainutdinov
mesh_terms: D015115:5,6-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D001245:Association Learning / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects*; D004594:Electrophysiology; D004924:Escape Reaction / Q000187:drug effects*; D006372:Helix, Snails; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D012018:Reflex / Q000187:drug effects; D018490:Serotonin Agents / Q000494:pharmacology*
chemical_list: D018490:Serotonin Agents; D015115:5,6-Dihydroxytryptamine