title: Immobilization of animal cells in fixed bed bioreactors.
abstract: Immobilization of animal cells has become a highly popular means of achieving high-density animal cell cultures. The advantages of immobilization are that it stabilizes cells in culture and enables long-term culture periods to be achieved. Immobilization increases cell productivity by increasing the usable substrate surface area for anchorage-dependent cells, or by facilitating perfusion of anchorage-independent cells. A method for production of secreted biological products from anchorage-dependent and independent cells is described. The method is based on immobilization of animal cells within the polymeric matrix of polyurethane foam, packed in a fixed bed bioreactor.
authors.affiliation: Department of Biotechnology, Israel Institute for Biological Research, Ness Ziona, 70450, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Lazar