Synthesis and studies of modified oligonucleotides-directed triple helix formation at the purine-pyrimidine interrupted site.
Triple helix formation is still restricted to oligopurine-oligopyrimidine double stranded DNA target. Herein we focus on our progress achieved in nucleobase and oligonucleotide modifications area to address the chemical challenge to circumvent the recognition of a purine-pyrimidine base pair interruption in an oligopyrimidine-oligopurine DNA sequence.
Jazouli
Mohamed
M
Laboratoire de Chimie des Plantes et de Synthèse Organique et Bioorganique, Universitè des Sciences, Rabat, Morocco.
Guianvarc'h
Dominique
D
Bougrin
Khalid
K
Soufiaoui
Mohamed
M
Vierling
Pierre
P
Benhida
Rachid
R
D020029:Base Pairing; D001483:Base Sequence; D006860:Hydrogen Bonding; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D011687:Purines; D011743:Pyrimidines; D013329:Structure-Activity Relationship; D013816:Thermodynamics
D009838:Oligodeoxyribonucleotides; D011687:Purines; D011743:Pyrimidines