title: Synthesis and biological evaluation of a series of new cyclohexenyl nucleosides.
abstract: A series of cyclohexenyl nucleosides (1-8) were successfully prepared with moderate yield and their cytotoxicity and antiviral activity were investigated. Among the eight new compounds, only the diaminopurine analogue 8 showed pronounced activity against HSV-1, HSV-2.
authors.affiliation: Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Ping
authors.initials: P
authors.lastname: Gu
authors.forename: Jordi
authors.initials: J
authors.lastname: Morral
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Jef
authors.initials: J
authors.lastname: Rozenski
authors.forename: Roger
authors.initials: R
authors.lastname: Busson
authors.forename: Arthur
authors.initials: A
authors.lastname: Van Aerschot
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Piet
authors.initials: P
authors.lastname: Herdewijn
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003510:Cyclohexanes; D003587:Cytomegalovirus / Q000187:drug effects; D003603:Cytotoxins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D014645:Herpesvirus 3, Human / Q000187:drug effects; D006801:Humans; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D003510:Cyclohexanes; D003603:Cytotoxins; D009705:Nucleosides