title: Bone marrow-derived vascular cells in response to injury.
abstract: Intimal hyperplasia is a key lesion for various vascular disorders such as atherosclerosis, postangioplasty restenosis and transplant arteriopathy. It has widely been accepted that intimal smooth muscle cells (SMC) originate from the medial layer in the same artery. However, recent studies suggest that bone marrow can also provide circulating progenitors for vascular SMC. Bone marrow-derived SMC participate in neointimal formation in animal models of allotransplantation, severe mechanical injury and hyperlipidemia-induced atherosclerosis. In human, transplantation arteriopathy also seems to involve circulating SMC, but their role in atherosclerosis and restenosis remains to be elucidated. Mobilization, differentiation and proliferation steps of SMC progenitors will provide promising targets for novel therapeutic approaches against proliferative vascular diseases.
authors.affiliation: Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan. kyokote-cib@umin.ac.jp
authors.forename: Koutaro
authors.initials: K
authors.lastname: Yokote
authors.forename: Ayako
authors.initials: A
authors.lastname: Take
authors.forename: Chiaki
authors.initials: C
authors.lastname: Nakaseko
authors.forename: Kazuki
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Masaki
authors.initials: M
authors.lastname: Fujimoto
authors.forename: Harukiyo
authors.initials: H
authors.lastname: Kawamura
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Maezawa
authors.forename: Miki
authors.initials: M
authors.lastname: Nishimura
authors.forename: Seijiro
authors.initials: S
authors.lastname: Mori
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Saito
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology*; D001808:Blood Vessels / Q000166:cytology; D001854:Bone Marrow Cells / Q000502:physiology*; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000293:injuries / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology; D014180:Transplantation; D017539:Tunica Intima / Q000166:cytology; D017540:Tunica Media / Q000166:cytology