Correlates of one-year survival inpatients with cardiogenic shock complicating acute myocardial infarction: angiographic findings from the SHOCK trial.
OBJECTIVE
The goal of this study was to describe the core laboratory angiographic findings of "SHould we emergently revascularize Occluded Coronaries for cardiogenic shocK" (SHOCK) trial participants and to determine the relationship of angiographic parameters to one-year survival.


BACKGROUND
In the SHOCK trial, emergency revascularization improved one-year survival of patients with cardiogenic shock compared with initial medical stabilization including thrombolysis and intraaortic balloon counterpulsation.


METHODS
Coronary angiography was performed by protocol in 147 of 152 (97%) patients in the emergency revascularization (ERV) group and by clinical selection in 100 of 150 (67%) patients in the initial medical stabilization (IMS) group. Of the other 50 IMS patients, 45 of 50 (90%) died rapidly and did not undergo angiography.


RESULTS
Left ventricular ejection fraction was correlated with one-year survival in both treatment groups (p < 0.001). In the IMS group, the hazard ratio for death was 2.59 (95% confidence interval 1.47 to 4.58, p = 0.001) per diseased vessel (0/1 vs. 2 vs. 3). In the ERV group, the hazard ratio for death per diseased vessel was 1.11 (95% confidence interval 0.79 to 1.56, p = 0.559). Multivariate analysis of the angiography cohort (without regard for left ventriculogram measurements) identified initial Thrombolysis in Myocardial Infarction flow grade (p = 0.032), number of diseased vessels (for IMS patients only, p = 0.024), and culprit vessel (p = 0.004) as independent correlates of one-year survival, even after adjustment for key clinical factors. In the smaller cohort with left ventricular ejection fraction measured (n = 97), ejection fraction and culprit vessel remained independently correlated with survival.


CONCLUSIONS
For patients in cardiogenic shock, left ventricular function and culprit vessel were independent correlates of one-year survival.
Sanborn
Timothy A
TA
Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA. tsanorn@enh.org
Sleeper
Lynn A
LA
Webb
John G
JG
French
John K
JK
Bergman
Geoffrey
G
Parikh
Manish
M
Wong
S Chiu
SC
Boland
Jean
J
Pfisterer
Matthias
M
Slater
James N
JN
Sharma
Samin
S
Hochman
Judith S
JS
D000368:Aged; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D007423:Intra-Aortic Balloon Pumping; D008297:Male; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000150:complications; D009204:Myocardial Revascularization; D016016:Proportional Hazards Models; D012770:Shock, Cardiogenic / Q000000981:diagnostic imaging / Q000401:mortality* / Q000628:therapy*; D015912:Thrombolytic Therapy; D016277:Ventricular Function, Left / Q000502:physiology