title: Thionucleotides as inhibitors of ribonucleotide reductase.
abstract: Ribonucleosides and xylonucleosides bearing a disulfide function on the sugar ring were synthesized. Ribonucleosides belonging to the cytidine series were found to efficiently reduce dNTP pools in the human lymphoblastoid CEM/SS cell line.
authors.affiliation: Institut de Biochimie Biophysique Moléculaire et Cellulaire, Université de Paris Sud, UMR CNRS 8619, Orsay, France.
authors.forename: B
authors.initials: B
authors.lastname: Roy
authors.forename: S
authors.initials: S
authors.lastname: Chambert
authors.forename: M
authors.initials: M
authors.lastname: Lepoivre
authors.forename: J L
authors.initials: JL
authors.lastname: Décout
mesh_terms: D003562:Cytidine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology; D007202:Indicators and Reagents; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors*; D013873:Thionucleotides / Q000494:pharmacology*; D014994:Xylose
chemical_list: D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D013873:Thionucleotides; D003562:Cytidine; D014994:Xylose; D012264:Ribonucleotide Reductases