title: Absence of clinical signs of cardiac denervation after percutaneous myocardial laser revascularization.
abstract: BACKGROUND
  Percutaneous myocardial revascularization with laser (PMR) is a catheter-based technique that has generated much interest in the treatment of patients with severe coronary artery disease. Several mechanisms have been proposed to explain the reported clinical benefits of this technique. Cardiac autonomic denervation is among these.
  
  
  METHODS
  We studied 32 consecutive patients with chronic severe angina not suitable for other revascularization approaches. Canadian Class Society (CCS) class clinical assessment, Naughton exercise stress test, and scintigraphic myocardial perfusion were evaluated before and 1 and 6 months after PMR. Ewing's autonomic tests, heart rate variability (HRV), and plasmatic catecholamines were assessed before revascularization in non-diabetic and diabetic patients and repeated 1 month after PMR in 13 non-diabetics. A psychological test was carried out before PMR to evaluate the attitude towards this new procedure.
  
  
  RESULTS
  All the markers of autonomic cardiac control were unmodified after the procedure. Moreover, scintigraphic perfusion measured in the lasered areas was similar before and after the procedure. On the other hand, the clinical conditions significantly improved (CCS class from 3+/-0.8 to 1.9+/-0.9 at 1 month, P<0.01) and the exercise-related ischemic threshold was significantly better (from 311+/-28 to 453+/-51 s, P<0.05). The patients with a psychologically 'positive' expectation for this new procedure had results comparable to those with a 'negative' expectation.
  
  
  CONCLUSIONS
  PMR improves symptoms in patients with end-stage coronary artery disease in the absence of any detectable clinical sign of heart denervation.
authors.affiliation: Medicina Interna II, Ospedale L. Sacco, via GB Grassi 74, Milan 20157, Italy. stefanog@fisiopat.sacco.unimi.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Guzzetti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Colombo
authors.forename: Emanuela
authors.initials: E
authors.lastname: Piccaluga
authors.forename: Luca
authors.initials: L
authors.lastname: Tagliabue
authors.forename: Renata
authors.initials: R
authors.lastname: Magatelli
authors.forename: Giulia
authors.initials: G
authors.lastname: Cantoni
authors.forename: Maurizio
authors.initials: M
authors.lastname: Viecca
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000503:physiopathology / Q000523:psychology / Q000601:surgery*; D001341:Autonomic Nervous System / Q000502:physiology; D015415:Biomarkers / Q000097:blood; D002395:Catecholamines / Q000097:blood; D002908:Chronic Disease; D003324:Coronary Artery Disease / Q000503:physiopathology / Q000523:psychology / Q000601:surgery*; D003714:Denervation; D003920:Diabetes Mellitus / Q000503:physiopathology / Q000523:psychology / Q000601:surgery; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000294:innervation*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D015425:Myocardial Reperfusion; D009204:Myocardial Revascularization; D011581:Psychological Tests; D013223:Statistics as Topic; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D002395:Catecholamines