[Relationship between aberrant FHIT transcripts and hepatocellular carcinoma].
OBJECTIVE
To study the relationship between aberrant FHIT transcripts and hepatocellular carcinoma (HCC).


METHODS
Reverse transcription-polymerase chain reaction (RT-PCR) and single strand conformational polymorphism (SSCP) assays were used to analyze the transcripts and mutations of FHIT gene in 24 matched tumorous tissues and para-tumorous tissues from patients with HCC and in 4 normal liver tissues.


RESULTS
Aberrant FHIT transcripts were observed in 11 out of 24 (46%) tumorous tissues and in 2 (8%) of the matched para-tumorous tissues.


CONCLUSIONS
FHIT aberrant transcripts may play an important role in the pathogenesis of hepatocellular carcinoma.
Yu
Yong-chun
YC
Center Laboratory, Railway Hospital Affiliated to Tongji University, Shanghai 200072, China.
Sun
Fen-yong
FY
Li
Zhi
Z
Lu
Shao-yi
SY
Teng
Xiao-hong
XH
D017766:Acid Anhydride Hydrolases; D006528:Carcinoma, Hepatocellular / Q000235:genetics*; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics*; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000099170:Bis(5'-adenosyl)triphosphatase
D017766:Acid Anhydride Hydrolases; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D000099170:Bis(5'-adenosyl)triphosphatase