Gammadelta T cell non-responsiveness in Campylobacter jejuni-associated Guillain-Barré syndrome patients.
To seek evidence for a role of molecular mimicry in the induction of Guillain-Barré syndrome (GBS), the authors studied Campylobacter jejuni-reactive T lymphocytes in patients with GBS. In contrast to controls, gammadelta T cells of patients with GBS with antecedent C jejuni infections failed to respond to C jejuni. Supplementing cell cultures with the cytokines interleukin-2 or interleukin-15 resulted in restoration of the gammadelta T cell proliferative response. Gammadelta T cell non-responsiveness may lead to defective regulation of antibody production, and in this way an (auto)immune response against ganglioside-like epitopes on peripheral nerve may cause GBS.
Van Rhijn
I
I
Department of Neurology, University Medical Center Utrecht, The Netherlands.
Logtenberg
T
T
Ang
C W
CW
Van den Berg
L H
LH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002169:Campylobacter Infections / Q000276:immunology*; D016123:Campylobacter jejuni / Q000276:immunology*; D002455:Cell Division / Q000187:drug effects / Q000276:immunology; D002478:Cells, Cultured; D005260:Female; D020275:Guillain-Barre Syndrome / Q000276:immunology*; D006801:Humans; D007158:Immunologic Techniques; D019409:Interleukin-15 / Q000494:pharmacology; D007376:Interleukin-2 / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D018716:Molecular Mimicry / Q000276:immunology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*
D019409:Interleukin-15; D007376:Interleukin-2; D016692:Receptors, Antigen, T-Cell, gamma-delta