title: Tumor escape from immune response: mechanisms and targets of activity.
abstract: Immune system plays an important role in control of tumor progression. Effective antitumor immune response depends on close interaction of several elements of immune system. They include antigen-presenting cells, different subsets of T cells, B cells and NK cells. However, tumor cells developed a number of mechanisms to escape recognition and elimination by immune system. In this review we will discuss these mechanisms and address possible approaches to correct them.
authors.affiliation: H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA. dgabril@moffitt.usf.edu
authors.forename: Dmitry
authors.initials: D
authors.lastname: Gabrilovich
authors.forename: Vladimir
authors.initials: V
authors.lastname: Pisarev
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D000938:Antigen-Presenting Cells / Q000166:cytology / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D007157:Immunologic Surveillance; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology; D022423:Myeloid Cells / Q000166:cytology / Q000276:immunology; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy; D013601:T-Lymphocytes / Q000276:immunology; D019139:Tumor Escape / Q000276:immunology*