Effect of monensin on Mayaro virus replication in monkey kidney and Aedes albopictus cells.
The effect of a cationic ionophore, monensin, on the replication of Mayaro virus in monkey kidney TC7 and Aedes albopictus cells has been studied. Treatment of these cells with 1 micromol/l monensin during infection did not affect the virus protein synthesis but inhibited severely the virus replication. Electron microscopy of the cells infected with Mayaro virus and treated with monensin revealed that the morphogenesis of Mayaro virus was impaired in TC7 but not in A. albopictus cells.
De Campos
R M
RM
Department of Virology, Prof. Paulo de Góes Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, CEP 21941-590, RJ, Brazil.
Ferreira
D F
DF
Da Veiga
V F
VF
Rebello
M A
MA
Rebello
M C S
MC
D000330:Aedes / Q000166:cytology; D000524:Alphavirus / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D000818:Animals; D002460:Cell Line; D002999:Clone Cells / Q000382:microbiology; D000882:Haplorhini; D007668:Kidney / Q000166:cytology; D008985:Monensin / Q000494:pharmacology*; D014764:Viral Proteins / Q000096:biosynthesis / Q000187:drug effects*; D014779:Virus Replication / Q000187:drug effects*
D014764:Viral Proteins; D008985:Monensin