title: [Diagnostic usefulness of intradermal test for clonorchiasis in patients with pancreatobiliary diseases].
abstract: OBJECTIVE
  The diagnosis of clonorchiasis is based on demonstrating eggs in stool or bile. It is believed that bile examination is the most precise method for detecting eggs. We evaluated diagnostic usefulness of intradermal test (IDT) by comparing it with the result of bile examination.
  
  
  METHODS
  For 88 patients with pancreatobiliary diseases, we examined Clonorchis sinensis eggs in bile and performed IDT for clonorchiasis. The bile was obtained from endoscopic nasobiliary or percutaneous transhepatic biliary drainage tubes.
  
  
  RESULTS
  We calculated ROC curve to decide the cut-off value of IDT in determining diagnostic accuracy on the basis of bile examination. We chose a value of 40 mm2, which significantly improved the sensitivity, without reducing the specificity. With a cut-off value of 40 mm2, the sensitivity, specificity, positive and negative predictive values of IDT were 81.5%, 67.2%, 52.4%, and 89.1%, respectively. The value of IDT was not affected by age and showed no difference between benign and malignant diseases. However, in egg-positive patients, the mean value was lower in malignant diseases than in benign diseases.
  
  
  CONCLUSIONS
  In patients with pancreatobiliary diseases, IDT with a cut-off value of 40 mm2 seems to be a valuable supplementary diagnostic test for clonorchiasis in view of its high sensitivity.
authors.affiliation: Department of Internal Medicine, University of Ulsan College of Medicine, Ulsan, Korea. gicolon@unitel.co.kr
authors.forename: Kwang Ro
authors.initials: KR
authors.lastname: Joo
authors.forename: Mi Suk
authors.initials: MS
authors.lastname: Lee
authors.forename: Tae Guen
authors.initials: TG
authors.lastname: Yun
authors.forename: Yeon Ik
authors.initials: YI
authors.lastname: Choo
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Lee
authors.forename: Young Chul
authors.initials: YC
authors.lastname: Jo
authors.forename: Dae Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Do Ha
authors.initials: DH
authors.lastname: Kim
authors.forename: Neung Hwa
authors.initials: NH
authors.lastname: Park
authors.forename: Jae Hoo
authors.initials: JH
authors.lastname: Park
mesh_terms: D000368:Aged; D001646:Bile / Q000469:parasitology; D001660:Biliary Tract Diseases / Q000175:diagnosis*; D003003:Clonorchiasis / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007428:Intradermal Tests; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity