title: Transverse arch hypoplasia may predispose patients to aneurysm formation after patch repair of aortic coarctation.
abstract: BACKGROUND
  Thoracic aortic aneurysm after patch repair of aortic coarctation is a potentially lethal complication. We hypothesized that transverse arch hypoplasia in association with patch repair of aortic coarctation predisposes aneurysm formation.
  
  
  METHODS
  A retrospective analysis was performed on all patients undergoing isolated aortic coarctation repair at the University of Virginia Health Systems between 1970 and 1995. Of 244 repairs, 38 patients underwent patch repair. These 38 patients were divided into two groups. The aneurysm group (n = 15) had aortic aneurysms develop at the repair site, which required aneurysmectomy. The nonaneurysm group (n = 23) did not have any aneurysms develop. Univariate analysis and Fisher's exact text were used to identify factors that independently predict aneurysm formation.
  
  
  RESULTS
  Univariate analysis demonstrated aortic arch hypoplasia associated with patch repair independently predicts future aneurysm formation (p < 0.01). Patients who had an aneurysm develop also had a similar incidence of bicuspid aortic valves, mild restenosis, and late hypertension compared with patients in the nonaneurysm group.
  
  
  CONCLUSIONS
  Aneurysm formation after patch repair of aortic coarctation develops into a subgroup of patients. Aortic arch hypoplasia associated with coarctation independently predicts future aneurysm formation.
authors.affiliation: Department of Surgery, Division of Thoracic and Cardiovascular Surgery, University of Virginia Health System, Charlottesville, Virginia 22908, USA.
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Maxey
authors.forename: Stephanus J
authors.initials: SJ
authors.lastname: Serfontein
authors.forename: T Brett
authors.initials: TB
authors.lastname: Reece
authors.forename: Karen S
authors.initials: KS
authors.lastname: Rheuban
authors.forename: Irving L
authors.initials: IL
authors.lastname: Kron
mesh_terms: D001013:Aorta, Thoracic / Q000002:abnormalities* / Q000473:pathology; D001014:Aortic Aneurysm / Q000209:etiology*; D001017:Aortic Coarctation / Q000601:surgery*; D005260:Female; D006349:Heart Valve Diseases / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D011183:Postoperative Complications; D012189:Retrospective Studies