Computer-aided tissue engineering: overview, scope and challenges.
Advances in computer-aided technology and its application with biology, engineering and information science to tissue engineering have evolved a new field of computer-aided tissue engineering (CATE). This emerging field encompasses computer-aided design (CAD), image processing, manufacturing and solid free-form fabrication (SFF) for modelling, designing, simulation and manufacturing of biological tissue and organ substitutes. The present Review describes some salient advances in this field, particularly in computer-aided tissue modeling, computer-aided tissue informatics and computer-aided tissue scaffold design and fabrication. Methodologies of development of CATE modelling from high-resolution non-invasive imaging and image-based three-dimensional reconstruction, and various reconstructive techniques for CAD-based tissue modelling generation will be described. The latest development in SFF to tissue engineering and a framework of bio-blueprint modelling for three-dimensional cell and organ printing will also be introduced.
Sun
Wei
W
Laboratory for Computer-Aided Tissue Engineering, Department of Mechanical Engineering and Mechanics, College of Engineering, Drexel University, 3141 Chestnut Street, Philadelphia, PA 19104, USA. sunwei@drexel.edu
Darling
Andrew
A
Starly
Binil
B
Nam
Jae
J
D000818:Animals; D001187:Artificial Organs; D001672:Biocompatible Materials / Q000138:chemical synthesis; D001808:Blood Vessels / Q000502:physiology; D017076:Computer-Aided Design; D006801:Humans; D008846:Micromanipulation; D008954:Models, Biological; D023822:Tissue Engineering / Q000379:methods*; D016378:Tissue Transplantation / Q000379:methods*
D001672:Biocompatible Materials