New solid supports linking nucleoside scaffolds.
An easy and efficient strategy to obtain new nucleoside based solid supports in which the nucleoside moieties have been anchored to the solid support through the nucleobase is here proposed. A simple and efficient solid-phase synthesis of 5' and 3'-derivatized uridine analogues has so been developed, following methodologies well established in organic chemistry.
de Champdoré
Marcella
M
Dipartimento di Chimica Organica e Biochimica, Università degli Studi di Napoli Federico II, Napoli, Italy.
De Napoli
Lorenzo
L
Di Fabio
Giovanni
G
Messere
Anna
A
Montesarchio
Daniela
D
Piccialli
Gennaro
G
D002625:Chemistry, Organic / Q000379:methods; D007202:Indicators and Reagents; D009705:Nucleosides / Q000737:chemistry*; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D009705:Nucleosides; D014529:Uridine