title: Pulmonary hemodynamics in obstructive sleep apnea: frequency and causes of pulmonary hypertension.
abstract: The association between nocturnal apneas and transient pulmonary hypertension (PHT) has been well documented. However, there is controversy over the frequency and pathophysiological mechanisms of daytime pulmonary hypertension in patients with obstructive sleep apnea (OSAS). The present study sought to evaluate frequency and mechanisms of pulmonary hypertension in patients with OSAS. It included 49 consecutive patients with polysomnographically proven OSAS without pathological lung function testing. All patients performed daytime measurements of pulmonary hemodynamics at rest and during exercise (50-75W). Six patients (12%) had resting PHT mean pulmonary of artery pressure (PAPM) of >20 mmHg), whereas 39 patients (80%) showed PHT during exercise (PAPM >30 mmHg). Multiple regression analysis revealed 3 independent contributing factors for mean pulmonary artery pressure during exercise (PAPMmax): body mass index, age and total lung capacity % of predicted. Twenty-five of the 39 patients with pathologically high PAPMmax (64%) showed elevated pulmonary capillary wedge pressures (PCWPmax > 20 mmHg), whereas no patient had elevated pulmonary vascular resistance (PVRmax > 120 dynes x s x cm(-5)). In conclusion, daytime PHT during exercise is frequently seen in patients with OSAS and normal lung function testing and is mainly caused by abnormally high PCWP, whereas PVR seems to play a minor role.
authors.affiliation: Department of Internal Medicine II, University Hospital, Ulm University, Germany. martin.hetzel@medizin.uni-ulm.de
authors.forename: M
authors.initials: M
authors.lastname: Hetzel
authors.forename: M
authors.initials: M
authors.lastname: Kochs
authors.forename: N
authors.initials: N
authors.lastname: Marx
authors.forename: H
authors.initials: H
authors.lastname: Woehrle
authors.forename: I
authors.initials: I
authors.lastname: Mobarak
authors.forename: V
authors.initials: V
authors.lastname: Hombach
authors.forename: J
authors.initials: J
authors.lastname: Hetzel
mesh_terms: D000328:Adult; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000503:physiopathology; D011669:Pulmonary Wedge Pressure; D012044:Regression Analysis; D012129:Respiratory Function Tests; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*