title: Neuroendocrine tumours of the digestive tract report of two cases and literature review.
abstract: Neuroendocrine tumors (NET) of the digestive system are rare. They comprise only 1% of all the tumors of the gastrointestinal tract. The aim of this study is to report two cases of exceptional localization of non secretary neuroendocrine tumors. Their difficulty in diagnosis, treatment and controversy in chemotherapy merit their study in depth. These are two patients that were treated in the department of general surgery (Beau Séjour) in Charles Nicolle Hospital for non secretary (NET) of the pancreas and stomach. The first was presented as a painless epigastria mass with frequent diarrhea. The second was presented as a painful mass in the left hypochondriac area without any other symptoms. Biochemical evaluation confirmed their non secretary properties. Surgery remains the first line of treatment. It was possible for the gastric, but not for the pancreatic tumor. Both were very advanced and had metastasis. Histopathological evaluation and immunohistochemical study using the method of peroxydase antiperoxydase (PAP) complexes for some special monoclonal antibodies confirmed the diagnosis. Chemotherapy of both cases was mal tolerated and was discussed in details.
authors.affiliation: Service de Chirurgie Beau Séjour, Hôpital Charles Nicolle, Tunis, Tunisie.
authors.forename: Ramzi
authors.initials: R
authors.lastname: Nouira
authors.forename: Iman
authors.initials: I
authors.lastname: Janabi
authors.forename: Jamel
authors.initials: J
authors.lastname: Ben Achour
authors.forename: Fethi
authors.initials: F
authors.lastname: Guesmi
authors.forename: Mohamed Aziz
authors.initials: MA
authors.lastname: Hani
authors.forename: Ali
authors.initials: A
authors.lastname: Cherif
authors.forename: Mounir
authors.initials: M
authors.lastname: Daghfous
authors.forename: Ibtissem
authors.initials: I
authors.lastname: Bouasker
authors.forename: Riadh
authors.initials: R
authors.lastname: Zribi
authors.forename: Samia
authors.initials: S
authors.lastname: Ben Osman
authors.forename: Ayoub
authors.initials: A
authors.lastname: Zoghlami
authors.forename: Nabil
authors.initials: N
authors.lastname: Najah
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D007150:Immunohistochemistry; D008197:Lymph Node Excision; D008875:Middle Aged; D009362:Neoplasm Metastasis; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000628:therapy; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000601:surgery; D013997:Time Factors