title: Arterial compliance adds to conventional risk factors for prediction of angiographic coronary artery disease.
abstract: BACKGROUND
  Arterial compliance is related to left ventricular hypertrophy and risk for cardiovascular disease events; however, its association with coronary artery stenosis remains uncertain. We sought to assess the relation between lower extremity arterial compliance and presence of angiographically defined coronary artery disease.
  
  
  METHODS
  Lower extremity arterial compliance was measured with the use of a noninvasive air plethysmography technique in 376 subjects undergoing routine diagnostic coronary angiography.
  
  
  RESULTS
  Measures of calf arterial compliance were significantly associated with the presence of one or more stenoses > or =50% compared with no stenoses, even after adjustment for age, sex, smoking, diabetes, hypertension, hypercholesterolemia, and obesity (P =.03). Measures of thigh arterial compliance were also lower in subjects with disease, although this association did not reach statistical significance (P =.07). Receiver operator curves illustrate the incremental predictive ability of calf arterial compliance over and above age, sex, and conventional risk factors.
  
  
  CONCLUSIONS
  Lower extremity arterial compliance is associated with presence of significant coronary stenoses in a cardiac catheterization laboratory referral population. This observation lends support for additional efforts to determine the utility of vascular stiffness measures in both clinical and pre-clinical populations to guide treatment and prevention efforts.
authors.affiliation: Department of Internal Medicine/Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1045, USA. dherring@wfubmc.edu
authors.forename: David M
authors.initials: DM
authors.lastname: Herrington
authors.forename: Karen
authors.initials: K
authors.lastname: Kesler
authors.forename: J h C
authors.initials: Jh
authors.lastname: Reiber
authors.forename: Warren
authors.initials: W
authors.lastname: Davis
authors.forename: W Virgil
authors.initials: WV
authors.lastname: Brown
authors.forename: Ronald
authors.initials: R
authors.lastname: Helms
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Mallon
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Raines
mesh_terms: D000328:Adult; D000368:Aged; D001158:Arteries / Q000503:physiopathology; D003187:Compliance; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010991:Plethysmography / Q000379:methods; D012372:ROC Curve; D015203:Reproducibility of Results; D012307:Risk Factors; D013223:Statistics as Topic