Synthesis, stability, and biological evaluation of 1,3-dihydrobenzo[c]furan analogue of d4T and its SATE pronucleotide.
The anti-HIV activity and stability studies of 1,3-dihydrobenzo[c]furan analogue of d4T are reported. The corresponding mononucleoside phosphotriester derivative bearing a S-pivaloyl-2-thioethyl (tBuSATE) group, as biolabile phosphate protection, is also studied.
Len
Christophe
C
Laboratoire des Glucides, Université de Picardie-Jules Verne, Amiens, France. christophe.len@sc.u-picardie.fr
Selouane
Abdelmajid
A
Postel
Denis
D
Villa
Pierre
P
Aubertin
Anne-Marie
AM
Egron
David
D
Gosselin
Gilles
G
Périgaud
Christian
C
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001572:Benzofurans; D002460:Cell Line; D004355:Drug Stability; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology*; D006207:Half-Life; D006801:Humans; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018119:Stavudine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013237:Stereoisomerism; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D001572:Benzofurans; D011355:Prodrugs; D018119:Stavudine