title: Recent progress in the design of selectin inhibitors.
abstract: The selectins are a family of cell-adhesion proteins that mediate the early stages of leukocyte recruitment from the blood stream to sites of tissue damage through recognition of the carbohydrate epitope sialyl Lewis(x) (sLe(x)). Current development of small molecule based inhibitors of this process and their clinical potential to address numerous acute and chronic diseases are explored.
authors.affiliation: School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
authors.forename: Siri Ram
authors.initials: SR
authors.lastname: Chhabra
authors.forename: Aisyah S Abdul
authors.initials: AS
authors.lastname: Rahim
authors.forename: Barrie
authors.initials: B
authors.lastname: Kellam
mesh_terms: D000818:Animals; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008024:Ligands; D018716:Molecular Mimicry; D019087:Selectins / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology
chemical_list: D002241:Carbohydrates; D008024:Ligands; D019087:Selectins