title: Detection of ligands from a dynamic combinatorial library by X-ray crystallography.
authors.affiliation: Astex Technology, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, UK. m.congreve@astex-technology.com
authors.forename: Miles S
authors.initials: MS
authors.lastname: Congreve
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Davis
authors.forename: Lindsay
authors.initials: L
authors.lastname: Devine
authors.forename: Cesare
authors.initials: C
authors.lastname: Granata
authors.forename: Marc
authors.initials: M
authors.lastname: O'Reilly
authors.forename: Paul G
authors.initials: PG
authors.lastname: Wyatt
authors.forename: Harren
authors.initials: H
authors.lastname: Jhoti
mesh_terms: D001681:Biological Assay; D042846:CDC2-CDC28 Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D018360:Crystallography, X-Ray; D051357:Cyclin-Dependent Kinase 2; D008024:Ligands; D008958:Models, Molecular; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
chemical_list: D008024:Ligands; D042846:CDC2-CDC28 Kinases; D051357:Cyclin-Dependent Kinase 2