Gingipains as candidate antigens for Porphyromonas gingivalis vaccine.
Porphyromonas gingivalis (P. gingivalis), a gram-negative anaerobe, is involved in the pathogenesis of periodontal disease, and is found frequently in the subgingival flora in patients with periodontitis. This organism possesses a variety of virulence factors including lipopolysaccharide, capsular material, fimbriae and proteases (enzymes). Among the P. gingivalis antigens, enzymes such as Arginine-specific gingipains (RgpA, RgpB) and lysine-specific gingipain (Kgp) have been studied for their ability to induce biologically significant antibodies. This review summarizes recent information on the gingipains and their possible application in the development of an anti-P. gingivalis vaccine.
Nakagawa
Taneaki
T
Department of Dentistry and Oral Surgery, School of Medicine, Keio University, Tokyo, Japan. tane@sc.itc.keio.ac.jp
Saito
Atsushi
A
Hosaka
Yasuo
Y
Ishihara
Kazuyuki
K
D018829:Adhesins, Bacterial; D000818:Animals; D000941:Antigens; D016866:Bacteroidaceae Infections / Q000517:prevention & control*; D003546:Cysteine Endopeptidases / Q000627:therapeutic use*; D000080867:Gingipain Cysteine Endopeptidases; D006388:Hemagglutinins / Q000627:therapeutic use*; D006801:Humans; D010587:Phagocytosis; D016966:Porphyromonas gingivalis / Q000276:immunology* / Q000378:metabolism / Q000472:pathogenicity; D017434:Protein Structure, Tertiary; D014612:Vaccines; D037521:Virulence Factors
D018829:Adhesins, Bacterial; D000941:Antigens; D000080867:Gingipain Cysteine Endopeptidases; D006388:Hemagglutinins; D014612:Vaccines; D037521:Virulence Factors; D003546:Cysteine Endopeptidases