title: Design and synthesis of A3 adenosine receptor ligands, 2'-fluoro analogues of Cl-IB-MECA.
abstract: Synthesis of 2'-deoxy-2'-fluoro-N6-substituted adenosines as bioisosteres of Cl-IB-MECA and their binding affinities to A3 adenosine receptor are described.
authors.affiliation: Division of Chemistry and Molecular Engineering, Seoul National University, Seoul, South Korea.
authors.forename: Hea Ok
authors.initials: HO
authors.lastname: Kim
authors.forename: Jae Gyu
authors.initials: JG
authors.lastname: Park
authors.forename: Hyung Ryong
authors.initials: HR
authors.lastname: Moon
authors.forename: Prashantha
authors.initials: P
authors.lastname: Gunaga
authors.forename: Moo Hong
authors.initials: MH
authors.lastname: Lim
authors.forename: Moon Woo
authors.initials: MW
authors.lastname: Chun
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Jacobson
authors.forename: Hee-Doo
authors.initials: HD
authors.lastname: Kim
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D000818:Animals; D001921:Brain / Q000378:metabolism; D015195:Drug Design; D005459:Fluorides; D006801:Humans; D008024:Ligands; D051381:Rats; D043684:Receptor, Adenosine A3 / Q000378:metabolism*
chemical_list: D008024:Ligands; D043684:Receptor, Adenosine A3; D000241:Adenosine; D005459:Fluorides; C090034:2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide