title: Who are patients on conventional antipsychotics?
abstract: The advent of atypical antipsychotics presented psychiatrists with an effective way of treating psychosis without the many side effects associated with conventional agents. Given the superiority of atypical antipsychotics, we examined demographic information and treatment histories of patients currently treated with conventional antipsychotics, especially in regard to treatment with atypical agents. Medication histories and demographic information for 276 patients admitted to an urban hospital were obtained by patient/family interviews and review of medical records. Chi-square and logistic regression tests were used to analyze data for possible predictive factors of which patients within the sample were still receiving conventional antipsychotics for treatment. Seventy-eight (28%) patients were currently being treated with conventional antipsychotics. More than half of them had never received a trial of an atypical agent. African-Americans, who are more likely to suffer adverse effects from conventional antipsychotics, and substance abusers were overrepresented in this group. It is unclear to what extent ethnic or cultural bias played a role in determining medication choice. Because conventional antipsychotics are associated with more side effects and greater medication nonadherence, these patients should be evaluated for appropriateness of a trial with an atypical agent even if they are currently stable with a conventional antipsychotic.
authors.affiliation: University at Buffalo School of Medicine and Biomedical Sciences, Department of Psychiatry, State University of New York at Buffalo, USA.
authors.forename: Antoinette M
authors.initials: AM
authors.lastname: Valenti
authors.forename: Rajesh
authors.initials: R
authors.lastname: Narendran
authors.forename: Cynthia A
authors.initials: CA
authors.lastname: Pristach
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D044383:Black People; D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D008499:Medical Records / Q000706:statistics & numerical data; D008875:Middle Aged; D010349:Patient Compliance; D011618:Psychotic Disorders / Q000188:drug therapy*; D012044:Regression Analysis; D012189:Retrospective Studies; D001741:Black or African American
chemical_list: D014150:Antipsychotic Agents