title: Inhibition of vertebrate telomerases by the triphosphate derivatives of some biologically active nucleosides.
abstract: In order to clarify the effect of the base moiety of nucleotide analogs on telomerase inhibition, triphosphate derivatives of biologically active nucleosides, 3'-azido-3'-deoxythymidine (AZT), 2'-deoxy-2'-fluoroarafuranosylthymine (FaraT), acycloguanosine (ACG) and their guanine or thymine counterparts (AZdG, FaraG and ACT, respectively) were investigated. In all of the present cases, guanine derivatives showed more potent inhibition than their thymine counterparts.
authors.affiliation: Department of Biological Sciences, Teikyo University of Science and Technology, Uenohara, Yamanashi, Japan.
authors.forename: Toyofumi
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Hazuki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Jinmei
authors.forename: Yuko
authors.initials: Y
authors.lastname: Takayama
authors.forename: Mineo
authors.initials: M
authors.lastname: Saneyoshi
mesh_terms: D000818:Animals; D003854:Deoxyribonucleotides / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006147:Guanine / Q000031:analogs & derivatives; D006367:HeLa Cells; D006801:Humans; D007700:Kinetics; D009711:Nucleotides / Q000494:pharmacology*; D019098:Telomerase / Q000037:antagonists & inhibitors*; D013941:Thymine / Q000031:analogs & derivatives; D014714:Vertebrates
chemical_list: D003854:Deoxyribonucleotides; D004791:Enzyme Inhibitors; D009711:Nucleotides; D006147:Guanine; D019098:Telomerase; D013941:Thymine