title: Treatment of hypophonia with collagen vocal cord augmentation in patients with parkinsonism.
abstract: We conducted structured interviews of patients with Parkinson's disease (PD) and other parkinsonian disorders and their caregivers after augmentation of vocal folds with collagen injections. A total of 12 patients (mean age, 73.7 +/- 8.6 years) completed the questionnaire after an average of 3.0 +/- 1.7 collagen injections, with an average of 13.8 +/- 7.4 weeks between each injection. In addition to improvement in all six voice quality questions, there was significant improvement (P < 0.05) in the Glascow Benefit Inventory (GBI) score. The injection procedure was tolerated well by patients with an average duration of benefit lasting 7.8 +/- 8.5 weeks. Augmentation of vocal folds with collagen provides temporary improvement in voice in patients with parkinsonian hypophonia.
authors.affiliation: Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Amy N
authors.initials: AN
authors.lastname: Hill
authors.forename: Joseph
authors.initials: J
authors.lastname: Jankovic
authors.forename: Kevin D A T
authors.initials: KD
authors.lastname: Vuong
authors.forename: Don
authors.initials: D
authors.lastname: Donovan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003094:Collagen / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D020734:Parkinsonian Disorders / Q000150:complications* / Q000503:physiopathology; D017060:Patient Satisfaction; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014827:Vocal Cords / Q000187:drug effects*; D014832:Voice Disorders / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D014833:Voice Quality
chemical_list: D003094:Collagen