A right hemispheric frontocerebellar network for time discrimination of several hundreds of milliseconds.
Debate still surrounds the nature of the role of the dorsolateral prefrontal gyrus (DLPFC) in time perception. This region is frequently associated with working memory and is thus implicated as a so-called "accumulator" within a hypothesized internal clock model. However, we hypothesized that this region may have a more primary role in time perception. To test this hypothesis we used functional magnetic resonance imaging (fMRI) to examine the neural correlates of relatively pure time perception with a temporal discrimination task where intervals of 1 s had to be discriminated from those of 1.3, 1.4, and 1.5 s. Time perception in this particular time domain within the "perceived present" has not previously been investigated using fMRI. By using relatively short time periods to be discriminated and also contrasting activation with an order judgment task, we aimed to minimize the confounding aspects of sustained attention and working memory. In a group of 20 healthy right-handed adult males, neural activation associated with time discrimination was found in a predominantly right hemispheric network of right dorsolateral and inferior prefrontal cortices, right supplementary motor area, and left cerebellum. We conclude that right DLPFC, rather than having a purely working memory function, might be more centrally involved in time perception than previously thought.
Smith
Anna
A
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London, UK. spjwabs@iop.kcl.ac.uk
Taylor
Eric
E
Lidzba
Karen
K
Rubia
Katya
K
D000328:Adult; D002531:Cerebellum / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000502:physiology*; D010775:Photic Stimulation; D017397:Prefrontal Cortex / Q000502:physiology*; D013998:Time Perception / Q000502:physiology*