title: Synthesis of some new 2-alpha-L-arabinopyranosyl-1,2,4-triazines as potential antitumor chemotherapeutics.
abstract: Synthetic routes towards different 2-alpha-L-arabinopyranosyl-3-thioxo-2,3-dihydro-1,2,4-triazin-5(4H)-/ones or thiones were investigated. Primary human anticancer screening of two selected compounds resulted in an active compound against SF-268 (CNS) cell line.
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
authors.forename: Abdel Kader
authors.initials: AK
authors.lastname: Mansour
authors.forename: Mohga M
authors.initials: MM
authors.lastname: Eid
authors.forename: Nasser S A M
authors.initials: NS
authors.lastname: Khalil
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D014227:Triazines / Q000138:chemical synthesis* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D014227:Triazines