title: Potential of phosphorus nuclear magnetic resonance spectroscopy in studies of the energy metabolism of skeletal muscles.
abstract: The aim of the present study was to investigate the possibility of phosphorus magnetic resonance spectroscopy (MR spectroscopy) in the diagnosis of metabolic lesions of skeletal musculature in patients with intermittent claudication syndrome, chronic cardiac failure, and varicose diseases of the lower limbs. Studies included 50 males: 20 patients with intermittent claudication, 10 patients with chronic cardiac failure, and 10 patients with varicose veins. The control group consisted of 10 healthy volunteers. The following measures were determined: the phosphocreatinine index, the intracellular pH in the gastrocnemius muscle, and the half-recovery time for the phosphocreatinine index. The phosphocreatinine index and the pH at rest did not differ between study groups. Isotonic exercise produced no change in the phosphocreatinine index in the control group; patients with intermittent claudication showed a 26.1% decrease, patients with chronic cardiac failure showed an 8% decrease, and patients with varicose veins showed a 25.6% decrease. The only group showing a significant decrease in pH during exercise was the group of patients with intermittent claudication. This group also showed an inverse correlation between the pressure index and the extent of the decrease in the phosphocreatinine index. Thus, MR spectroscopy provides a non-invasive diagnostic method for lesions of energy metabolism in skeletal musculature in patients with deranged peripheral hemodynamics.
authors.affiliation: Department of Tomography, A. L. Myasnikov Institute of Clinical Cardiology, Russian Cardiological Scientific-Industrial Complex, Ministry of Health of the Russian Federation, 15a Third Cherepkovskaya Street, 121552, Moscow, Russia.
authors.forename: S K
authors.initials: SK
authors.lastname: Ternovoi
authors.forename: T N
authors.initials: TN
authors.lastname: Veselova
authors.forename: V E
authors.initials: VE
authors.lastname: Sinitsin
mesh_terms: D000328:Adult; D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D004734:Energy Metabolism / Q000502:physiology; D006333:Heart Failure / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D007383:Intermittent Claudication / Q000175:diagnosis / Q000378:metabolism*; D007866:Leg / Q000098:blood supply; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D010725:Phosphocreatine / Q000031:analogs & derivatives* / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism; D012016:Reference Values; D014648:Varicose Veins / Q000175:diagnosis / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D010725:Phosphocreatine; D010758:Phosphorus; C025403:phosphocreatinine