title: Subthalamic nucleus stimulation for Parkinson's disease preferentially improves akinesia of proximal arm movements compared to finger movements.
abstract: Deep brain stimulation of the subthalamic nucleus (STN-DBS) reduces akinesia in Parkinson's disease but its impact on fine motor functions was unknown. We assessed the effects of DBS and a levodopa (L-dopa) test on the timing of the precision grip in 18 patients. Improvement on UPDRS-items reflecting hand functions and the shortening of the first phases of the precision grip were more distinct in the L-dopa test than in the pure STN-DBS condition. Other akinesia items and the time for build-up of lifting force were equally improved in both conditions. This suggests that routine STN-DBS might not be equally effective on all aspects of fine motor functions.
authors.affiliation: Department of Neurology, Christian-Albrechts Universität Kiel, Kiel, Germany.
authors.forename: Roland
authors.initials: R
authors.lastname: Wenzelburger
authors.forename: Florian
authors.initials: F
authors.lastname: Kopper
authors.forename: Bao-Rong
authors.initials: BR
authors.lastname: Zhang
authors.forename: Karsten
authors.initials: K
authors.lastname: Witt
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hamel
authors.forename: Dieter
authors.initials: D
authors.lastname: Weinert
authors.forename: Johann
authors.initials: J
authors.lastname: Kuhtz-Buschbeck
authors.forename: Mukaddes
authors.initials: M
authors.lastname: Gölge
authors.forename: Michael
authors.initials: M
authors.lastname: Illert
authors.forename: Günther
authors.initials: G
authors.lastname: Deuschl
authors.forename: Paul
authors.initials: P
authors.lastname: Krack
mesh_terms: D000978:Antiparkinson Agents / Q000627:therapeutic use; D001132:Arm / Q000503:physiopathology*; D020820:Dyskinesias / Q000209:etiology / Q000628:therapy*; D004599:Electric Stimulation Therapy; D005385:Fingers / Q000503:physiopathology*; D018737:Hand Strength; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D009068:Movement / Q000528:radiation effects; D010300:Parkinson Disease / Q000150:complications / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000503:physiopathology / Q000528:radiation effects*; D013997:Time Factors
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa