Autophagy in yeast: a TOR-mediated response to nutrient starvation.
TOR plays a key role in cell growth and cell-cycle progression, but in addition recent studies have shown that TOR is also involved in the regulation of a number of molecular processes associated with nutrient deprivation, such as autophagy. In budding yeast, TOR negatively regulates activation of Apg1 protein kinase, which is essential for the induction of autophagy. This review describes recent research in this field and the mechanism by which TOR mediates induction of autophagy.
Kamada
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Department of Cell Biology, National Institute for Basic Biology, 444-8585, Okazaki, Japan.
Sekito
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T
Ohsumi
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Y
D048868:Adaptor Proteins, Signal Transducing; D000071187:Autophagy-Related Protein 5; D000071190:Autophagy-Related Protein 8 Family; D000071183:Autophagy-Related Proteins; D004268:DNA-Binding Proteins / Q000378:metabolism; D005979:Glutathione Peroxidase; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D011328:Prions / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000201:enzymology* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases
D048868:Adaptor Proteins, Signal Transducing; D000071187:Autophagy-Related Protein 5; D000071190:Autophagy-Related Protein 8 Family; D000071183:Autophagy-Related Proteins; D004268:DNA-Binding Proteins; D005979:Glutathione Peroxidase; D008869:Microtubule-Associated Proteins; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor); D011328:Prions; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D029701:Saccharomyces cerevisiae Proteins; D044767:Ubiquitin-Protein Ligases; C102268:ATG5 protein, S cerevisiae; C113757:ATG8 protein, S cerevisiae; C100984:TAP42 protein, S cerevisiae; C067020:URE2 protein, S cerevisiae; C477823:ATG1 protein, S cerevisiae; C071570:SNF1-related protein kinases; C083324:TOR1 protein, S cerevisiae