[Analysis of alkaline phosphatase staining results in 238 cases of malignant lymphoma].
OBJECTIVE
To examine the significance of alkaline phosphatase (ALP) staining in clinical characterization of malignant lymphoma cases.


METHODS
Fresh peripheral blood smear obtained from 238 cases of malignant lymphoma, including 23 cases with bone marrow involvement (BMI) 189 cases without BMI(NBMI), and 26 cases of lymphoma cell leukemia (LCL), were examined by ALP staining, and the results were compared with those of 40 normal control subjects.


RESULTS
With the gradual progression of lymphoma, the patients tended to have higher ALP scores, and the percentages of the subjects with a score higher than 250 in the control, NBMI, BMI and LCL were 0, 4.8%, 39.1%, 53.9% respectively, showing significant differences between the four groups.


CONCLUSIONS
Increased ALP activity can be indirectly indicative of lymphoma progression, and ALP staining results may provide insight into the clinical staging and prognosis of malignant lymphoma.
Lin
Rong
R
Department of Hematology, Nanfang Hospital, First Military Medical University, Guanzhou 510515, China.
Wang
Shi-shu
SS
Zhou
Shu-yun
SY
Xu
Xiao-lan
XL
Yi
Zheng-shan
ZS
Chen
Shan-wen
SW
Lin
Gang
G
Luo
Mei-yun
MY
D000293:Adolescent; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008223:Lymphoma / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D013194:Staining and Labeling
D000469:Alkaline Phosphatase