title: Epidemic spread of Pandoraea apista, a new pathogen causing severe lung disease in cystic fibrosis patients.
abstract: We show that Pandoraea apista must be added to the increasing list of pathogens capable of causing chronic lung infection in cystic fibrosis (CF) patients. It is most likely that this strain of P. apista was transmissible among patients with CF, leading to spread of infection from the index patient to 5 other patients exposed during participation in winter camps and/or hospitalization. All patients developed chronic infection with high levels of antibodies, and 4 patients had a downhill course of lung disease. P. apista must therefore be considered a new and sometimes important pathogen for CF patients. Cohort isolation prevented further spread of P. apista in our CF center.
authors.affiliation: Department of Paediatrics, Danish Cystic Fibrosis Center, Rigshospitalet, Copenhagen Ø, Denmark.
authors.forename: Inger Merete
authors.initials: IM
authors.lastname: Jørgensen
authors.forename: Helle Krogh
authors.initials: HK
authors.lastname: Johansen
authors.forename: Birgitte
authors.initials: B
authors.lastname: Frederiksen
authors.forename: Tacjana
authors.initials: T
authors.lastname: Pressler
authors.forename: Annelise
authors.initials: A
authors.lastname: Hansen
authors.forename: Peter
authors.initials: P
authors.lastname: Vandamme
authors.forename: Niels
authors.initials: N
authors.lastname: Høiby
authors.forename: Christian
authors.initials: C
authors.lastname: Koch
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000907:Antibodies, Bacterial / Q000097:blood; D001424:Bacterial Infections / Q000097:blood / Q000453:epidemiology* / Q000382:microbiology / Q000628:therapy / Q000635:transmission; D020562:Betaproteobacteria / Q000302:isolation & purification* / Q000472:pathogenicity; D015331:Cohort Studies; D015897:Comorbidity; D003550:Cystic Fibrosis / Q000453:epidemiology*; D003718:Denmark / Q000453:epidemiology; D004196:Disease Outbreaks; D018562:Disease Transmission, Infectious / Q000706:statistics & numerical data; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D009894:Opportunistic Infections / Q000097:blood / Q000453:epidemiology* / Q000382:microbiology / Q000628:therapy / Q000635:transmission; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000382:microbiology / Q000628:therapy / Q000635:transmission; D013183:Sputum / Q000382:microbiology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial