[Pharmacodynamics study on "tao hua zhi xie granule"].
The anthraco-propulsion and the drug induced mice diarrhea models were used to observe the intestine propulsion and the anti-diarrhea effect of "Tao Hua Zhi Xie Granule" (THZXG), and the anti-inflammation effect of THZXG was studied. The results showed that THZXG could obviously reduce the incidence and frequency of the mice diarrhea induced by Folium Sennae and castor-oil, and propelling movement of mice small intestine after hypodermic injection of neostigmine. The actions were acted in a dose-dependent manner. 11.70 and 17.55 mg/kg THZXG(ig) could also inhibit the increased permeability of intraperitoneal capillary induced by acetic acid in mice.
Shan
Limei
L
302 Hospital of PLA, Beijing 100039.
Zhao
Yanlin
Y
Xiao
Xiaohe
X
Cai
Guangming
G
He
Chengshan
C
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000930:Antidiarrheals / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D002368:Castor Oil; D003967:Diarrhea / Q000188:drug therapy / Q000503:physiopathology; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects; D008297:Male; D008419:Materia Medica / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000930:Antidiarrheals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008419:Materia Medica; C481900:tao hua tang; D002368:Castor Oil