title: Photoregulation of deacylation rate of acyl trypsin derived from photoresponsive inverse substrate.
abstract: The acyl trypsin was prepared by use of an inverse substrate, which is comprise of a photoresponsive 4-phenylazobenzoyl moiety. The acyl group in acyl trypsin has been shown to isomerize from trans-form (4t-trypsin) to cis-form (4c-trypsin)/from cis-form to trans-form by irradiation of UV-vis light. The deacylation rate of the cis-form (4c-trypsin) has been shown to be 18.6 times faster than that of the trans-form (4t-trypsin).
authors.affiliation: Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu, Hokkaido 061-0293, Japan. sekizaki@hoku-iryo-u.ac.jp
authors.forename: Haruo
authors.initials: H
authors.lastname: Sekizaki
authors.forename: Asako
authors.initials: A
authors.lastname: Kumagai
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Itoh
authors.forename: Eiko
authors.initials: E
authors.lastname: Toyota
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Horita
authors.forename: Yukari
authors.initials: Y
authors.lastname: Noguchi
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Tanizawa
mesh_terms: D003640:Dealkylation; D006868:Hydrolysis; D007700:Kinetics; D010777:Photochemistry; D013329:Structure-Activity Relationship; D014357:Trypsin / Q000737:chemistry*; D014466:Ultraviolet Rays
chemical_list: D014357:Trypsin