Dynamics of cell surface molecules during T cell recognition.
Recognition of foreign antigens by T lymphocytes is a very important component of vertebrate immunity-vital to the clearance of pathogenic organisms and particular viruses and necessary, indirectly, for the production of high affinity antibodies. T cell recognition is mediated by the systematic scanning of cell surfaces by T cells, which collectively express many antigen receptors. When the appropriate antigenic peptide bound to a molecule of the major histocompatibility complex is found-even in minute quantities-a series of elaborate cell-surface molecule and internal rearrangements take place. The sequence of events and the development of techniques required to observe these events have significantly enhanced our understanding of T cell recognition and may find application in other systems of transient cell:cell interactions as well.
Davis
Mark M
MM
Howard Hughes Medical Institute and the Department of Microbiology and Immunology, Stanford University, Stanford, California 94305-5323, USA. mdavis@cmgm.stanford.edu
Krogsgaard
Michelle
M
Huppa
Johannes B
JB
Sumen
Cenk
C
Purbhoo
Marco A
MA
Irvine
Darrell J
DJ
Wu
Lawren C
LC
Ehrlich
Lauren
L
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000276:immunology; D008958:Models, Molecular; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D011948:Receptors, Antigen, T-Cell