title: Assessment of multifocal electroretinogram abnormalities and their relation to morphologic characteristics in patients with large drusen.
abstract: OBJECTIVE
  To determine the extent of functional changes in the first-order kernel multifocal electroretinogram (mfERG) responses in patients with large drusen by means of a localized analysis and to determine correlations between mfERG responses and morphologic changes.
  
  
  METHODS
  Thirty-one eyes from 20 patients ages 58 to 84 years with large drusen (> or =5 drusen > or =63 microm diameter) were studied. The mfERGs were recorded with a stimulus of 103 hexagons and a flash intensity of 2.67 candela (cd).s-1.m-2. Each of the 103 single first-order kernel mfERG responses was analyzed and compared with those of age-matched healthy control subjects. Imaging studies, including color stereo fundus photography, red-free fundus photography, and fluorescein angiography, were performed in all patients, and morphologic changes (drusen in red-free fundus photography, staining or window defect in fluorescein angiography) were determined with a digital measurement tool. The mfERG responses were correlated to areas with and without morphologic changes.
  
  
  RESULTS
  Reduced responses were found in 10.0% (scalar products) and 4.0% (response densities) and delayed implicit times in 13.8% (N1), 18.9% (P1), and 23.8% (N2) of all mfERGs. Abnormal mfERG responses extended up to 25 degrees in radius. Significant morphologic-functional relations were detected in only a few patients. Abnormal mfERG variables were present in areas without morphologic changes.
  
  
  CONCLUSIONS
  Patients with large drusen exhibit functional changes in the cone-driven pathways evaluated by the mfERG, indexed particularly by implicit times. Morphologically visible changes do not predict retinal function. Large drusen are associated with a more general retinal dysfunction.
authors.affiliation: Department of Ophthalmology and Section of Neurobiology, Physiology, and Behavior, University of California, Davis, USA. chgerth@web.de
authors.forename: Christina
authors.initials: C
authors.lastname: Gerth
authors.forename: David
authors.initials: D
authors.lastname: Hauser
authors.forename: Peter B
authors.initials: PB
authors.lastname: Delahunt
authors.forename: Lawrence S
authors.initials: LS
authors.lastname: Morse
authors.forename: John S
authors.initials: JS
authors.lastname: Werner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D004596:Electroretinography / Q000379:methods; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D010781:Photography; D012160:Retina / Q000502:physiology*; D015593:Retinal Drusen / Q000503:physiopathology*; D014792:Visual Acuity