title: Stability, vigor, and inherent versatility of novel amino linker and spacer phosphoramidites.
abstract: Novel amino linker and spacer phosphoramidites were synthesized from methoxyoxalamido (MOX) percursors possessing a secondary hydroxyl, which when phosphitylated endowed stability to the corresponding phosphoramidites. The synthetic strategy is robust, and the chemistry is reactive towards a variety of primary aliphatic diamines and amino alcohols to produce distinctly unique phosphoramidites. The selection of building blocks determines the length and physico-chemical properties of the phosphoramidite tethering arms, and the synthesis can be specifically tailored to suit individual requirement.
authors.affiliation: Fidelity Systems, Inc., Gaithersburg, Maryland 20879, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Morocho
authors.forename: V N
authors.initials: VN
authors.lastname: Karamyshev
authors.forename: N N
authors.initials: NN
authors.lastname: Polushin
mesh_terms: D000588:Amines; D021901:DNA, Intergenic / Q000138:chemical synthesis*; D004355:Drug Stability; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009943:Organophosphorus Compounds
chemical_list: D000588:Amines; D021901:DNA, Intergenic; D007202:Indicators and Reagents; D009943:Organophosphorus Compounds; C434331:phosphoramidite