Phototransduction: shedding light on translocation.
Light induces the migration of arrestin to the photosensitive membrane in both vertebrate and invertebrate photoreceptors. New work has identified a phosphoinositide lipid binding domain in Drosophila arrestin and implicates PIP(3) in control of arrestin translocation.
Hardie
Roger C
RC
Cambridge University Department of Anatomy, Downing Street, Cambridge CB2 3DY, UK. rch14@hermes.cam.ac.uk
D000818:Animals; D019393:Arrestin / Q000378:metabolism* / Q000502:physiology; D004330:Drosophila; D008954:Models, Biological; D010716:Phosphatidylinositols / Q000378:metabolism; D010786:Photoreceptor Cells / Q000502:physiology*; D021381:Protein Transport / Q000502:physiology*; D015293:Transducin / Q000378:metabolism; D014785:Vision, Ocular / Q000502:physiology*
D019393:Arrestin; D010716:Phosphatidylinositols; D015293:Transducin