Lithium dose prediction based on 24 hours single dose levels: a prospective evaluation.
The authors present the results of the utilization of a pharmacokinetic prediction test for lithium posology. Based on a single point (plasma lithium determination 24 h after a single dose) such a test aims to adapt the posology as soon as the second day of treatment rather than after one week as clinicians must wait for a steady state to be achieved. Built on the previous work of Perry, the test targeted the plasma lithium level at 0.8 +/- 0.1 mmol l(-1). Thirty-one patients took part in the study. There were two drop-out cases and the results were available for 29 patients: among them, 51% had their plasma level in the targeted zone. Although there was no control group, the prediction test often allowed us to use a higher dose than the usual fixed dose whose amount is limited by the risk of overdosing for the slower metabolizers.
Gervasoni
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N
Département de Psychiatrie, Clinique de Psychiatrie Adulte-Programme Dépression, Hôpitaux Universitaires de Genève, Domaine de Belle-Idée, 16-18, bd Saint-Georges, CH-1205 Geneva, Switzerland. Nicola.Gervasoni@hcuge.ch
Zona-Favre
M-P
MP
Osiek
Ch
Ch
Roth
L
L
Bondolfi
G
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Bertschy
G
G
D000328:Adult; D000465:Algorithms; D000928:Antidepressive Agents / Q000009:adverse effects / Q000097:blood* / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007700:Kinetics; D016651:Lithium Carbonate / Q000009:adverse effects / Q000097:blood* / Q000493:pharmacokinetics; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000188:drug therapy* / Q000378:metabolism; D010352:Patient Dropouts; D011446:Prospective Studies; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced
D000928:Antidepressive Agents; D016651:Lithium Carbonate