Characterization of experimental equine glanders.
Considerable advances in understanding of the disease caused by Burkholderia mallei have been made employing a combination of tools including genetic techniques and animal infection models. The development of small animal models has allowed us to assess the role of a number of putative virulence determinants in the pathogenesis of disease due to B. mallei. Due to the difficulties in performing active immunization studies in small animals, and due to the fact that the horse is the target mammalian species for glanders, we have initiated experimental studies on glanders in horses. Intratracheal deposition of B. mallei produced clinical glanders with organisms being recovered from tissues of infected horses. The model should prove to be of considerable value in our ongoing studies on the pathogenesis and vaccine development for glanders.
Lopez
Jose
J
National Centre for Foreign Animal Disease, 1015 Arlington St., Suite T2300, Winnipeg, Man., Canada R3E 3M4.
Copps
John
J
Wilhelmsen
Catherine
C
Moore
Richard
R
Kubay
Julie
J
St-Jacques
Marcel
M
Halayko
Stacey
S
Kranendonk
Christiaan
C
Toback
Shannon
S
DeShazer
David
D
Fritz
David L
DL
Tom
Marina
M
Woods
Donald E
DE
D000818:Animals; D019117:Burkholderia / Q000302:isolation & purification*; D018562:Disease Transmission, Infectious / Q000662:veterinary; D005896:Glanders / Q000453:epidemiology / Q000382:microbiology*; D006734:Horse Diseases / Q000382:microbiology*; D006736:Horses