title: [Clinical analysis of pregnancy in second and third trimesters complicated severe acute respiratory syndrome].
abstract: OBJECTIVE
  To explore and analyze the clinical manifestation, diagnosis, management and maternal-perinatal prognosis of severe acute respiratory syndrome (SARS)-complicated pregnancy in second and third trimesters.
  
  
  METHODS
  Clinical data of 5 inpatients with SARS-complicated pregnancy in second and third trimesters from 4(th) February to 17(th) March 2003 were analyzed retrospectively.
  
  
  RESULTS
  Five patients were all primigravida (including 2 twins). Two were infected in second trimester while the other 3 in third trimester with 2 hospital-acquired infections and 3 community-acquired infections. All patients had fever (5/5), 3 chills or rigor, 4 cough; 2 with decreased lymphocyte, 2 decreased platelet, 3 elevated alanine aminotransferase (ALT), 4 hypoalbuminemia, 5 abnormal chest radiographs. All 5 patients were cured with 1 requiring intensive care. 5 neonates including 1 twins have been followed up without evidence of SARS infections up to now. In a twin-pregnancy 1 fetus was lost while the pregnant's situation is stable.
  
  
  CONCLUSIONS
  Common diagnostic criteria were Suitable for SARS-complicated pregnancy in second and third trimesters, but attention should be paid to the interaction between SARS and special pathological changes during pregnancy. Patients should be isolated and monitored intensively with timely cesarean section in severe cases, which could significantly decrease the maternal-perinatal mortality. The use of corticosteroids and psychological supports need further study.
authors.affiliation: Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Guangzhou 510120, China.
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Zhang
authors.forename: Yun-hui
authors.initials: YH
authors.lastname: Wang
authors.forename: Lei-ning
authors.initials: LN
authors.lastname: Chen
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Yu-fen
authors.initials: YF
authors.lastname: Xie
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D002681:China / Q000453:epidemiology; D018352:Coronavirus Infections / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D011024:Pneumonia, Viral / Q000453:epidemiology / Q000628:therapy; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011379:Prognosis; D045473:Severe acute respiratory syndrome-related coronavirus; D045169:Severe Acute Respiratory Syndrome / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology
chemical_list: D000998:Antiviral Agents; D005938:Glucocorticoids