title: Bicyclic nucleoside inhibitors of varicella-zoster virus: 5'-chloro and 3'-chloro derivatives.
abstract: We have recently discovered bicyclic furopyrimidines as potent and selective inhibitors of VZV. In order to investigate the structural requirements for antiviral activity we have succesfully synthesised some 3'-chloro and 5'-chloro derivatives. The compounds have been tested against VZV and CMV, but displayed no significant in vitro activity.
authors.affiliation: Welsh School of Pharmacy, Cardiff University, Cardiff, UK. luonig@cf.ac.uk
authors.forename: G
authors.initials: G
authors.lastname: Luoni
authors.forename: C
authors.initials: C
authors.lastname: McGuigan
authors.forename: G
authors.initials: G
authors.lastname: Andrei
authors.forename: R
authors.initials: R
authors.lastname: Snoeck
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects; D015195:Drug Design; D005459:Fluorides; D014645:Herpesvirus 3, Human / Q000187:drug effects*; D008958:Models, Molecular; D015394:Molecular Structure; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014994:Xylose
chemical_list: D000998:Antiviral Agents; D001643:Bridged Bicyclo Compounds; D011741:Pyrimidine Nucleosides; D014994:Xylose; D005459:Fluorides