Circadian rhythms. Liver regeneration clocks on.
In some simple protozoans and unicellular algae, the cell cycle clock is strongly influenced by the circadian clock, such that mitotic cell division takes place only at certain times of the day. Now, as Schibler reports in his Perspective, new work on regenerating liver cells in mice (Matsuo et al.) reveals that the cell cycle clock of mammalian cells is also under the yoke of the master circadian oscillator.
Schibler
Ueli
U
Department of Molecular Biology, University of Geneva, CH-1211 Geneva 4, Switzerland. ueli.schibler@molbio.unige.ch
D056930:ARNTL Transcription Factors; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D001683:Biological Clocks; D016203:CDC2 Protein Kinase / Q000378:metabolism; D056926:CLOCK Proteins; D018797:Cell Cycle Proteins; D002455:Cell Division; D002940:Circadian Rhythm; D056931:Cryptochromes; D019926:Cyclin B / Q000378:metabolism; D056744:Cyclin B1; D029721:Drosophila Proteins; D005136:Eye Proteins; D005420:Flavoproteins / Q000235:genetics / Q000378:metabolism; D016195:G2 Phase; D005786:Gene Expression Regulation; D006498:Hepatectomy; D022781:Hepatocytes / Q000166:cytology* / Q000378:metabolism; D008115:Liver Regeneration; D051379:Mice; D008938:Mitosis; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D056950:Period Circadian Proteins; D010766:Phosphorylation; D017956:Photoreceptor Cells, Invertebrate; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D056930:ARNTL Transcription Factors; D051792:Basic Helix-Loop-Helix Proteins; D016203:CDC2 Protein Kinase; D056926:CLOCK Proteins; D018797:Cell Cycle Proteins; D056931:Cryptochromes; D019926:Cyclin B; D056744:Cyclin B1; D029721:Drosophila Proteins; D005136:Eye Proteins; D005420:Flavoproteins; D009687:Nuclear Proteins; D056950:Period Circadian Proteins; D011505:Protein-Tyrosine Kinases; D043562:Receptors, G-Protein-Coupled; D015534:Trans-Activators; D014157:Transcription Factors; C538961:Bmal1 protein, mouse; C534700:Ccnb1 protein, mouse; C503698:CycB protein, Drosophila; C539023:Per1 protein, mouse; C513312:Per2 protein, mouse; C119828:cry protein, Drosophila; C538944:Clock protein, mouse; C499348:Wee1 protein, mouse