title: Myelin oligodendrocyte glycoprotein is expressed in the peripheral nervous system of rodents and primates.
abstract: The myelin oligodendrocyte glycoprotein (MOG) is a minor CNS myelin-specific protein that is an important candidate autoantigen in multiple sclerosis. We now report that MOG mRNA transcripts are present in the peripheral nervous system of rodents and primates at levels approximately ten-fold lower than in brain as demonstrated by real time PCR. A major source of this signal are Schwann cells which are also shown to express MOG protein within their cytoplasm in vitro by immunohistochemistry. Expression of MOG by Schwann cells associated with tissue innervation may account for the widespread distribution of low levels of MOG mRNA transcripts, and potentially may provide a source of antigen that can influence the composition and function of the MOG-specific immune repertoire.
authors.affiliation: Department of Neuroimmunology, Max-Planck Institute for Neurobiology, Am Klopferspitz 18a, 82152 Martinsried, Germany. pagany@neuro.mpg.de
authors.forename: Maria
authors.initials: M
authors.lastname: Pagany
authors.forename: Maja
authors.initials: M
authors.lastname: Jagodic
authors.forename: Anna
authors.initials: A
authors.lastname: Schubart
authors.forename: Danielle
authors.initials: D
authors.lastname: Pham-Dinh
authors.forename: Corinne
authors.initials: C
authors.lastname: Bachelin
authors.forename: Anne
authors.initials: A
authors.lastname: Baron van Evercooren
authors.forename: François
authors.initials: F
authors.lastname: Lachapelle
authors.forename: Tomas
authors.initials: T
authors.lastname: Olsson
authors.forename: Christopher
authors.initials: C
authors.lastname: Linington
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D007150:Immunohistochemistry; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000096:biosynthesis* / Q000235:genetics; D063308:Myelin-Oligodendrocyte Glycoprotein; D014066:Palatine Tonsil / Q000378:metabolism; D017933:Peripheral Nervous System / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012583:Schwann Cells / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism
chemical_list: C571326:MOG protein, human; C571328:Mog protein, rat; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D012333:RNA, Messenger