Comparative study of flavonoids in experimental models of inflammation.
The anti-inflammatory activities of flavonols (quercetin, rutin and morin) and flavanones (hesperetin and hesperidin) were investigated in animal models of acute and chronic inflammation. Rutin was only effective in the chronic process, principally in adjuvant arthritis. On neurogenic inflammation induced by xylene, only the flavanones were effective; besides, these compounds were the most effective on subchronic process. The most important compound in reducing paw oedema induced by carrageenan was quercetin.
Rotelli
Alejandra Ester
AE
Cátedra de Farmacología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700 San Luis, Argentina. arotelli@unsl.edu.ar
Guardia
Teresita
T
Juárez
Américo Osvaldo
AO
de la Rocha
Nadir Ernesto
NE
Pelzer
Lilian Eugenia
LE
D000818:Animals; D001169:Arthritis, Experimental / Q000517:prevention & control; D002351:Carrageenan; D004195:Disease Models, Animal; D004423:Ear / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005419:Flavonoids / Q000737:chemistry / Q000627:therapeutic use*; D006569:Hesperidin / Q000737:chemistry / Q000627:therapeutic use; D006614:Hindlimb / Q000473:pathology; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D015394:Molecular Structure; D011794:Quercetin / Q000737:chemistry / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012431:Rutin / Q000737:chemistry / Q000627:therapeutic use; D014992:Xylenes; D047309:Flavones
D002351:Carrageenan; D005419:Flavonoids; D006569:Hesperidin; D011794:Quercetin; D012431:Rutin; D014992:Xylenes; C008548:morin; D047309:Flavones; C013015:hesperetin