Synthesis of a base-protected xylo-LNA adenine nucleoside.
Synthesis of (1S,3R,4R,7R)-7-hydroxy-1-hydroxymethyl-3-(6-N-benzoyl-adenin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane (2), a base-protected xylo-LNA adenine nucleoside, has been accomplished using a convergent synthetic strategy starting from 1,2-di-O-acetylfuranose 3.
Bryld
Torsten
T
Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, Odense M, Denmark.
Wengel
Jesper
J
D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry*; D007202:Indicators and Reagents; D008968:Molecular Conformation; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; C477371:locked nucleic acid; C014251:9-xylosyladenine; D000241:Adenosine