Expanding the clinical utility of therapeutic proteins: activated protein C variants with improved pharmacological properties.
Vasserot
Alain P
AP
Applied Molecular Evolution, 3520 Dunhill Street, San Diego, CA 92121, USA. avasserot@AME.biz
Watkins
Jeffry D
JD
D000818:Animals; D005343:Fibrinolytic Agents / Q000737:chemistry / Q000627:therapeutic use; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D009154:Mutation; D011355:Prodrugs; D011486:Protein C / Q000737:chemistry / Q000235:genetics / Q000502:physiology / Q000627:therapeutic use*; D015202:Protein Engineering; D011994:Recombinant Proteins / Q000737:chemistry / Q000627:therapeutic use; D015843:Serpins / Q000378:metabolism
D005343:Fibrinolytic Agents; D011355:Prodrugs; D011486:Protein C; D011994:Recombinant Proteins; D015843:Serpins; C421124:drotrecogin alfa activated