title: Left ventricular systolic function in myocardial infarction survivors treated with primary angioplasty, thrombolysis of angioplasty preceded by thrombolysis.
abstract: BACKGROUND
  Acute myocardial infarction (AMI) may be treated with thrombolysis, primary angioplasty or a combination of both methods. Preservation of left ventricular systolic function is an important goal of treatment.
  
  
  OBJECTIVE
  To assess whether the mode of treatment of AMI influences left ventricular systolic function measured 6 months after AMI.
  
  
  METHODS
  In a group of 108 patients who survived AMI, an echocardiographic examination was performed 6 months afterwards. Ejection fraction, wall motion score index, asynergy area index, infarcted wall motion score index and apical segments motion score index were measured. Patients were divided into three groups: those treated with thrombolysis only, treated with angioplasty or those who underwent angioplasty preceded by thrombolysis.
  
  
  RESULTS
  Global left ventricular systolic function was similar in all three groups. Compared to the two remaining groups, the group treated with combined therapy had significantly worse indexes of infarcted wall motion score and apical segments motion score. This group also included a significantly higher number of patients with akinetic or dyskinetic apical segments.
  
  
  CONCLUSIONS
  Echocardiographic examination of global left ventricular systolic function in MI survivors performed 6 months after AMI, reveals similar values regardless of the method used for AMI treatment. However, segmental systolic function in the area of infarcted wall and apical segments is significantly more altered in patients treated with angioplasty preceded by thrombolysis than in other analysed patients.
authors.affiliation: 3rd Department of Cardiology Silesian School of Medicine, Katowice, Poland.
authors.forename: Ewa
authors.initials: E
authors.lastname: Gaszewska-Zurek
authors.forename: Maria
authors.initials: M
authors.lastname: Paradowska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Maślankiewicz
authors.forename: Agata
authors.initials: A
authors.lastname: Gruszka
authors.forename: Michał
authors.initials: M
authors.lastname: Tendera
mesh_terms: D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D003131:Combined Modality Therapy; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008666:Metalloendopeptidases / Q000008:administration & dosage; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013300:Streptokinase / Q000008:administration & dosage; D016019:Survival Analysis; D017741:Survivors; D015912:Thrombolytic Therapy / Q000379:methods; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage; D016896:Treatment Outcome; D016277:Ventricular Function, Left
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase; D010959:Tissue Plasminogen Activator; D008666:Metalloendopeptidases; C022653:auR protein, Staphylococcus aureus