Cobalt-catalyzed carbocyclization of o-iodobenzaldehydes and o-iodophenylketones with alkynes.
[reaction: see text] Treatment of various o-iodobenzaldehydes and o-iodophenyl ketones with alkynes in the presence of Co(dppe)I(2) and Zn powder in acetonitrile at 80 degrees C afforded the corresponding indenols in moderate to excellent yields with exceedingly high regioselectivity. For most unsymmetrical alkynes tested, the carbocyclization gave a single regioisomer.
Chang
Kuo-Jui
KJ
Department of Chemistry, Tsing Hua University, Hsinchu, Taiwan 300, ROC.
Rayabarapu
Dinesh Kumar
DK
Cheng
Chien-Hong
CH