Hydrogen ion dynamics and the Na+/H+ exchanger in cancer angiogenesis and antiangiogenesis.
Tumour angiogenesis and cellular pH regulation, mainly represented by Na(+)/H(+) antiporter exchange, have been heretofore considered unrelated subfields of cancer research. In this short review, the available experimental evidence relating these areas of modern cancer research is introduced. This perspective also helps to design a new approach that facilitates the opening and development of novel research lines oriented towards a rational incorporation of anticancer drugs into more selective and less toxic therapeutic protocols. The final aim of these efforts is to control cancer progression and dissemination through the control of tumour angiogenesis. Finally, different antiangiogenic drugs that can already be clinically used to this effect are briefly presented.
Orive
G
G
Faculty of Pharmacy, Department of Pharmacy and Pharmaceutical Technology, University of the Basque Country, C Paseo de la Universidad no. 7, 01006 Vitoria, Spain.
Reshkin
S J
SJ
Harguindey
S
S
Pedraz
J L
JL
D000136:Acid-Base Equilibrium; D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D002455:Cell Division; D002465:Cell Movement; D002471:Cell Transformation, Neoplastic; D018450:Disease Progression; D006706:Homeostasis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009389:Neovascularization, Pathologic; D017923:Sodium-Hydrogen Exchangers / Q000502:physiology*
D020533:Angiogenesis Inhibitors; D017923:Sodium-Hydrogen Exchangers