title: Comparison of stepwise and simultaneous estimations of population pharmacokinetics and pharmacodynamics of TS-943.
abstract: The prediction performances of population pharmacokinetic-pharmacodynamic analysis of the two methods (a stepwise and a simultaneous estimations) were evaluated with respect to their accuracies and precisions. A study was designed to investigate the safety and efficacy of TS-943 by a 4 hours constant infusion in 36 healthy male subjects. Population analysis was performed using pharmacokinetic and pharmacodynamic models with NONMEM. The mean of the prediction error (MPE) and the root mean squared error (RMSE) served as a measure of accuracy and precision. In addition, a bootstrap validation was also performed. The results indicate that those population pharmacokinetic-pharmacodynamic parameters for the two methods were comparable. The results of simultaneous estimations are similar to those obtained using a stepwise estimation. The mean parameter estimates obtained with the additional 200 bootstrap replicates of data were within 15% of those obtained with the final model in both methods. The present results demonstrated that the accuracy of pharmacodynamic evaluations using a stepwise end a simultaneous estimations was comparable.
authors.affiliation: Clinical Research Division, Taisho Pharmaceutical Co., Ltd, Toshimaku, Tokyo, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Furuya
authors.forename: N
authors.initials: N
authors.lastname: Kato
authors.forename: S
authors.initials: S
authors.lastname: Jingu
authors.forename: M
authors.initials: M
authors.lastname: Akimoto
authors.forename: O
authors.initials: O
authors.lastname: Kasai
authors.forename: T
authors.initials: T
authors.lastname: Suwa
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Ogata
mesh_terms: D000328:Adult; D000578:Amidines / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology; D016001:Confidence Intervals; D006801:Humans; D008297:Male; D008954:Models, Biological; D015203:Reproducibility of Results; D013223:Statistics as Topic / Q000379:methods; D013844:Thiazoles / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D000578:Amidines; C409044:TS 943; D013844:Thiazoles