The synthesis and applications of 5-aminolevulinic acid (ALA) derivatives in photodynamic therapy and photodiagnosis.
A route has been developed to high-purity precursors, viz., ALA esters, to be used in photodiagnosis and photodynamic therapy. Hexyl, butyl and methyl 5-aminolevulinates are similar to the ALA acid in chemical stability and efficacy in producing the appropriate photosensitizer PpIX. Tests carried out on animal models showed the method based on the esters to be the more selective.
Dabrowski
Zbigniew
Z
Industrial Chemistry Research Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.
Kwaśny
Mirosław
M
Kamiński
Jarosław
J
Bełdowicz
Maria
M
Lewicka
Lidia
L
Obukowicz
Bozena
B
Kaliszewski
Miron
M
Pirozyńska
Ewa
E
D000622:Aminolevulinic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D004355:Drug Stability; D005453:Fluorescence; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D051379:Mice; D008807:Mice, Inbred BALB C; D009214:Myoma / Q000473:pathology / Q000628:therapy; D009368:Neoplasm Transplantation; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology*
D007202:Indicators and Reagents; D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid