title: Beta2-microglobulin clearance with super high flux hemodialysis: an ex vivo study.
abstract: BACKGROUND
  Beta2m accumulation induces disease in patients with end-stage renal failure (ESRF). Thus, its removal from patients with ESRF appears desirable. Current dialysis technology, however, has limited effectiveness.
  
  
  OBJECTIVE
  To measure beta2m clearance with a novel super high flux membrane.
  
  
  METHODS
  Ex vivo experimental study.
  
  
  METHODS
  Intensive Care Laboratory of Tertiary institution.
  
  
  METHODS
  Six volunteers.
  
  
  RESULTS
  At a blood flow of 300 ml/min, the clearance of beta2-MG increased from 113.5 +/- 38.5 ml/min with a dialysate flow rate of 200 ml/min to 184.8 +/- 61.1 ml/min with a flow rate of 300 ml/min and 195.0 +/- 60.0 ml/min with a 500 ml/min flow rate. The clearance of albumin was 4.5 ml/min with a dialysate flow rate of 200 ml/min, 5.2 ml/min for a flow rate of 300 ml/min and 5.8 ml/min for a flow rate of 500 ml/min.
  
  
  CONCLUSIONS
  High levels of beta2m clearance can be achieved with a super high flux membrane while albumin losses remain limited.
authors.affiliation: Department of Intensive Care, Austin & Repatriation Medical Centre, Melbourne, Australia.
authors.forename: W C R
authors.initials: WC
authors.lastname: Lee
authors.forename: S
authors.initials: S
authors.lastname: Uchino
authors.forename: N
authors.initials: N
authors.lastname: Fealy
authors.forename: I
authors.initials: I
authors.lastname: Baldwin
authors.forename: S
authors.initials: S
authors.lastname: Panagiotopoulos
authors.forename: H
authors.initials: H
authors.lastname: Goehl
authors.forename: S
authors.initials: S
authors.lastname: Morgera
authors.forename: H H
authors.initials: HH
authors.lastname: Neumayer
authors.forename: R
authors.initials: R
authors.lastname: Bellomo
mesh_terms: D016001:Confidence Intervals; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008567:Membranes, Artificial; D006435:Renal Dialysis / Q000379:methods*; D001613:beta 2-Microglobulin / Q000097:blood*
chemical_list: D008567:Membranes, Artificial; D001613:beta 2-Microglobulin