title: Reproductive performance following midtrimester termination of pregnancy.
abstract: The aim of the study was to determine the impact of midtrimester abortion with extra-amniotic PGE(2) on future fertility and reproduction. Two hundred and fifteen women were enrolled. The mean induction-to-abortion interval was 21.3 h. The complication rate was 11.7%. Twenty women (9.3%) were lost to follow-up, 82 patients (38.1%) used contraception. Spontaneous pregnancy occurred in 110 out of 113 women who desired fertility (97%). Three patients were defined as infertile but conceived following treatment. The average time between the abortion and the next conception was 15.9 months (range 1-77 months). Seventy patients (63.7%) delivered at term. Premature delivery occurred in 18 patients (16.4%). Eighteen women aborted spontaneously in the first and 3 in the second trimester. One extrauterine pregnancy occurred. Second-trimester abortion with extra-amniotic PGE(2) is a safe procedure with a low rate of complication. Apparently it does not affect future fertility, but may be associated with an increased rate of premature deliveries in future gestations.
authors.affiliation: Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Debby
authors.forename: M
authors.initials: M
authors.lastname: Glezerman
authors.forename: R
authors.initials: R
authors.lastname: Sagiv
authors.forename: O
authors.initials: O
authors.lastname: Sadan
authors.forename: G
authors.initials: G
authors.lastname: Malinger
authors.forename: A
authors.initials: A
authors.lastname: Golan
mesh_terms: D000028:Abortion, Induced / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D015232:Dinoprostone / Q000008:administration & dosage; D005260:Female; D005306:Fertilization; D005313:Fetal Death / Q000628:therapy; D005334:Fever / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D007752:Obstetric Labor, Premature / Q000453:epidemiology / Q000209:etiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D013997:Time Factors; D014592:Uterine Hemorrhage / Q000453:epidemiology
chemical_list: D015232:Dinoprostone