Rapidly progressive human herpesvirus 8-associated solid anaplastic lymphoma in a patient with AIDS--associated Kaposi sarcoma.
We report a case of rapidly progressive solid lymphoma with anaplastic large cell morphology, followed by systemic Kaposi sarcoma in an adult patient with AIDS. The lymphoma cells expressed human herpesvirus 8 (HHV-8)-encoded latent and lytic proteins and Epstein-Barr virus-encoded small RNA, suggesting that this case could be categorized into HHV-8-associated solid lymphoma, a recently identified disease entity.
Yamamoto
Yoshihiko
Y
AIDS Clinical Center, International Medical Center of Japan, Toyama 1-21-1, Toyama, Shinjuku, Tokyo 162-8655, Japan.
Teruya
Katsuji
K
Katano
Harutaka
H
Niino
Hitoshi
H
Yasuoka
Akira
A
Kimura
Satoshi
S
Oka
Shinichi
S
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D003520:Cyclophosphamide / Q000008:administration & dosage; D018450:Disease Progression; D004317:Doxorubicin / Q000008:administration & dosage / Q000627:therapeutic use; D020031:Epstein-Barr Virus Infections / Q000150:complications; D017809:Fatal Outcome; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1; D006566:Herpesviridae Infections / Q000150:complications; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use; D016483:Lymphoma, AIDS-Related / Q000188:drug therapy / Q000821:virology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000821:virology*; D008297:Male; D016609:Neoplasms, Second Primary / Q000188:drug therapy / Q000821:virology*; D011241:Prednisone / Q000008:administration & dosage; D019438:Ritonavir / Q000627:therapeutic use; D019258:Saquinavir / Q000627:therapeutic use; D012514:Sarcoma, Kaposi / Q000188:drug therapy / Q000821:virology*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000821:virology*; D018119:Stavudine / Q000627:therapeutic use; D014412:Tumor Virus Infections / Q000821:virology*; D014750:Vincristine / Q000008:administration & dosage
D019380:Anti-HIV Agents; D019259:Lamivudine; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D018119:Stavudine; D019258:Saquinavir; D019438:Ritonavir; D011241:Prednisone