[Efficacy of enzyme-inducing agents in experimental tetrachloromethane poisoning].
Liver monooxygenase system inductors benzonal, galonal, and galodif exceed phenobarbital and zixorin in therapeutic efficacy with respect to rats poisoned with tetrachloromethane. The former drugs increase the content and catalytic activity of cytochrome P-450, improve conjugation with reduced glutathione, prevent the cytolysis of hepatocytes, and stimulate the bile secretion and the liver excretion function.
Saratikov
A S
AS
Department of Pharmacology, Siberian State Medical University, Moskovskii trakt 2, Tomsk, 634050 Russia.
Novozheeva
T P
TP
Vengerovskiĭ
A I
AI
D000818:Animals; D001463:Barbiturates / Q000627:therapeutic use*; D001559:Benzhydryl Compounds / Q000627:therapeutic use; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000201:enzymology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000201:enzymology; D004790:Enzyme Induction; D005260:Female; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000096:biosynthesis; D010634:Phenobarbital / Q000627:therapeutic use; D051381:Rats; D014508:Urea / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D001463:Barbiturates; D001559:Benzhydryl Compounds; C476801:halodif; C062695:halonal; D014508:Urea; D006899:Mixed Function Oxygenases; C016914:flumecinol; C002915:benzobarbital; D010634:Phenobarbital