title: Infants born to mothers with severe acute respiratory syndrome.
abstract: Severe acute respiratory syndrome (SARS) is a newly discovered infectious disease caused by a novel coronavirus. During the community outbreak in Hong Kong, 5 liveborn infants were born to pregnant women with SARS. A systematic search for perinatal transmission of the SARS-associated coronavirus, including serial reverse transcriptase-polymerase chain reaction assays, viral cultures, and paired serologic titers, failed to detect the virus in any of the infants. In addition, none of the infants developed clinical, radiologic, hematologic, or biochemical evidence suggestive of SARS. One preterm infant developed jejunal perforation and another developed necrotizing enterocolitis with ileal perforation shortly after birth. This case series is the first report to describe the clinical course of the first cohort of liveborn infants born to pregnant women with SARS.
authors.affiliation: Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital, Lai Chi Kok, New Territories, Hong Kong.
authors.forename: Chi C
authors.initials: CC
authors.lastname: Shek
authors.forename: Pak C
authors.initials: PC
authors.lastname: Ng
authors.forename: Genevieve P G
authors.initials: GP
authors.lastname: Fung
authors.forename: Frankie W T
authors.initials: FW
authors.lastname: Cheng
authors.forename: Paul K S
authors.initials: PK
authors.lastname: Chan
authors.forename: Malik J S
authors.initials: MJ
authors.lastname: Peiris
authors.forename: Kim H
authors.initials: KH
authors.lastname: Lee
authors.forename: Shell F
authors.initials: SF
authors.lastname: Wong
authors.forename: Hon M
authors.initials: HM
authors.lastname: Cheung
authors.forename: Albert M
authors.initials: AM
authors.lastname: Li
authors.forename: Ellis K L
authors.initials: EK
authors.lastname: Hon
authors.forename: Chung K
authors.initials: CK
authors.lastname: Yeung
authors.forename: Chun B
authors.initials: CB
authors.lastname: Chow
authors.forename: John S
authors.initials: JS
authors.lastname: Tam
authors.forename: Man C
authors.initials: MC
authors.lastname: Chiu
authors.forename: Tai F
authors.initials: TF
authors.lastname: Fok
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use; D002585:Cesarean Section; D015331:Cohort Studies; D004196:Disease Outbreaks; D020345:Enterocolitis, Necrotizing / Q000209:etiology; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D007077:Ileal Diseases / Q000209:etiology; D007231:Infant, Newborn; D007234:Infant, Premature; D018445:Infectious Disease Transmission, Vertical; D007416:Intestinal Perforation / Q000209:etiology; D007579:Jejunal Diseases / Q000209:etiology; D008297:Male; D008775:Methylprednisolone / Q000009:adverse effects / Q000627:therapeutic use; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology*; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications; D012254:Ribavirin / Q000009:adverse effects / Q000627:therapeutic use; D045473:Severe acute respiratory syndrome-related coronavirus / Q000302:isolation & purification; D045169:Severe Acute Respiratory Syndrome / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission*
chemical_list: D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D012254:Ribavirin; D008775:Methylprednisolone