Applications of RNA interference for studies in DNA damage processing, genome stability, mutagenesis, and cancer.
RNA interference, discovered only five years ago, is an important system for the control of gene expression. It is also quickly becoming a valuable experimental tool as it allows investigators to knock down the level of expression of specific genes. In this paper, we review some applications of this technology for studies in DNA damage processing, genome stability, mutagenesis, and cancer.
Bedford
Joel S
JS
Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA.
Liber
Howard L
HL
D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D005786:Gene Expression Regulation; D016678:Genome; D006801:Humans; D016296:Mutagenesis; D009369:Neoplasms / Q000235:genetics*; D034622:RNA Interference