title: Synthesis and analysis of nucleosides bearing pyrrolepolyamide binding to DNA.
abstract: An efficient synthesis of adenosine bearing pyrrolepolyamide 1 was achieved by coupling of 3 with 2. The CD spectra obtained at several [ligand ]/[duplex] ratios allowed verification of the formation complex of the DNA duplex [d(CGCAAATTGGC)/d(GCCAATTTGCG)] with 1.
authors.affiliation: Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo, Japan. kawasima@ps.toyaku.ac.jp
authors.forename: Etsuko
authors.initials: E
authors.lastname: Kawashima
authors.forename: Daisuke
authors.initials: D
authors.lastname: Itoh
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kamaike
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Terui
authors.forename: Tairo
authors.initials: T
authors.lastname: Oshima
mesh_terms: D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D009757:Nylons; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles
chemical_list: D009705:Nucleosides; D009757:Nylons; D009838:Oligodeoxyribonucleotides; D011758:Pyrroles; D004247:DNA