Solid-phase synthesis: a paradigm shift.
A personal review by the first graduate student of Professor R. Bruce Merrifield of the evolution of solid-phase synthesis and its acceptance by various subsets of the chemistry community. Solid-phase synthesis, as currently practised in the synthesis of biopolymers, combinatorial solid-phase organic chemistry, synthesis of natural products, catalyst selection, chemical ligation and materials development, has proven a paradigm shift for the chemistry community.
Marshall
Garland R
GR
Department of Biochemistry and Molecular Biophysics, Washington University Medical School, 700 S. Euclid Avenue, St Louis, MO 63110, USA. garland@pcg.wustl.edu
D020650:Combinatorial Chemistry Techniques / Q000266:history / Q000295:instrumentation / Q000379:methods; D049673:History, 20th Century; D049674:History, 21st Century; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000266:history; D014481:United States
D010455:Peptides