title: In vitro evaluation of the PUCA II intra-arterial LVAD.
abstract: The "pulsatile catheter" (PUCA) pump is a minimally invasive intra-arterial left ventricular assist device intended for acute support of critically ill heart failure patients. To assess the hydrodynamic performance of the PUCA II, driven by an Arrow AutoCat IABP driver, we used a (static) mock circulatory system in which the PUCA II was tested at different loading conditions. The PUCA II was subsequently introduced in a (dynamic) cardiovascular simulator (CVS) to mimic actual in vivo operating conditions, with different heart rates and 2 levels of left ventricular (LV) contractility. Mock circulation data shows that PUCA II pump performance is sensitive to afterload, pump rate and preload. CVS data demonstrate that PUCA II provides effective LV unloading and augments diastolic aortic pressure. The contribution of PUCA II to total flow is inversely related to LV contractility and is higher at high heart rates. We conclude that, with the current IABP driver, the PUCA II is most effective in 1:1 mode in left ventricles with low contractility.
authors.affiliation: Hydraulics Laboratory, Institute Biomedical Technology, Ghent University, Ghent, Belgium. stijn.vandenberghe@navier.ugent.be
authors.forename: S
authors.initials: S
authors.lastname: Vandenberghe
authors.forename: J P
authors.initials: JP
authors.lastname: Van Loon
authors.forename: P
authors.initials: P
authors.lastname: Segers
authors.forename: G
authors.initials: G
authors.lastname: Rakhorst
authors.forename: P
authors.initials: P
authors.lastname: Verdonck
mesh_terms: D000704:Analysis of Variance; D004867:Equipment Design; D006339:Heart Rate; D006353:Heart-Assist Devices; D066298:In Vitro Techniques; D008955:Models, Cardiovascular; D009200:Myocardial Contraction; D011673:Pulsatile Flow; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology