title: [The distribution of angiotensin converting enzyme gene I/D polymorphism and its relationship with essential hypertension].
abstract: OBJECTIVE
  To observe the distribution character of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in Chinese population and its relationship with essential hypertension.
  
  
  METHODS
  Polymerase chain reaction (PCR) technique was used to detect the angiotensin converting enzyme gene I/D polymorphism in 2966 subjects of Kailuan Coal Mine, and further restriction analysis was performed.
  
  
  RESULTS
  The frequencies of ACE II, ID, DD genotypes in total study population were 41.5%, 38.4%, 20.1%, respectively. The DD genotypes in hypertensive group and that in control group were 18.9% and 21.0%, respectively. There was no significant difference between hypertensive group and control group (P>0.05). The same result was seen after stratification by age and gender in each group, respectively(P>0.05). The DD genotype and D allele showed a tendency to decrease with the increase of age (P<0.001).
  
  
  CONCLUSIONS
  The above results suggested that essential hypertension was not associated with ACE I/D polymorphism. The distributions of ACE genotype and allele varied with age, and the subjects with the character of DD genotype were at higher risk of early death.
authors.affiliation: Department of Cardiology, Affiliated Kailuan Hospital, North China Coal Medical College, Tangshan, Hebei, 063000 PR China. vitaminc@sina.com
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Zhi-xia
authors.initials: ZX
authors.lastname: Shen
authors.forename: Hong-fen
authors.initials: HF
authors.lastname: Li
authors.forename: Ai-bin
authors.initials: AB
authors.lastname: Cheng
authors.forename: Qiu-xia
authors.initials: QX
authors.lastname: Hou
authors.forename: Shou-ling
authors.initials: SL
authors.lastname: Wu
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012737:Sex Factors
chemical_list: D007703:Peptidyl-Dipeptidase A