Preferential attachment in the protein network evolution.
The Saccharomyces cerevisiae protein-protein interaction map, as well as many natural and man-made networks, shares the scale-free topology. The preferential attachment model was suggested as a generic network evolution model that yields this universal topology. However, it is not clear that the model assumptions hold for the protein interaction network. Using a cross-genome comparison, we show that (a) the older a protein, the better connected it is, and (b) the number of interactions a protein gains during its evolution is proportional to its connectivity. Therefore, preferential attachment governs the protein network evolution. Evolutionary mechanisms leading to such preference and some implications are discussed.
Eisenberg
Eli
E
Compugen Ltd., 72 Pinchas Rosen Street, Tel Aviv 69512, Israel.
Levanon
Erez Y
EY
D019143:Evolution, Molecular; D016681:Genome, Fungal; D008954:Models, Biological; D010802:Phylogeny; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism
D029701:Saccharomyces cerevisiae Proteins