title: A phase II trial of bryostatin-1 administered by weekly 24-hour infusion in recurrent epithelial ovarian carcinoma.
abstract: Bryostatin-1 is a macrocyclic lactone whose main mechanism of action is protein kinase C modulation. We investigated its activity as a weekly 24-h infusion in recurrent ovarian carcinoma. In all, 17 patients were recruited and 11 had chemotherapy-resistant disease as defined by disease progression within 4 months of last cytotoxic therapy. All were evaluable for toxicity and 14 for response. There were no disease responses and the main toxicity was myalgia.
authors.affiliation: Cancer Research UK Department of Medical Oncology, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester, M20 4BX, UK. aclamp@picr.man.ac.uk
authors.forename: A R
authors.initials: AR
authors.lastname: Clamp
authors.forename: F H
authors.initials: FH
authors.lastname: Blackhall
authors.forename: P
authors.initials: P
authors.lastname: Vasey
authors.forename: M
authors.initials: M
authors.lastname: Soukop
authors.forename: R
authors.initials: R
authors.lastname: Coleman
authors.forename: G
authors.initials: G
authors.lastname: Halbert
authors.forename: L
authors.initials: L
authors.lastname: Robson
authors.forename: G C
authors.initials: GC
authors.lastname: Jayson
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D054713:Bryostatins; D018450:Disease Progression; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007783:Lactones / Q000008:administration & dosage* / Q000009:adverse effects; D018942:Macrolides; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000473:pathology; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy* / Q000473:pathology; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D054713:Bryostatins; D007783:Lactones; D018942:Macrolides; C046785:bryostatin 1