[Computer modeling the cytochrome P450 three-dimensional structure: problems and prospects].
The review is devoted to the description of basic approaches, problems and prospects of computer modelling of 3D structures of cytochromes P450 (P450s). The following questions have been are considered in the review: (1) the role of computer molecular modelling in P450s research; (2) basic stages of homology modelling of protein 3D structures; (3) purposes and tasks of molecular modelling; (4) problems of P450s homology modelling; (5) criteria for successful P450s homology modelling; (6) methods of P450s models refinement, verification of correctness and reliability.
Ivanov
A S
AS
Orekhovich Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, Pogodinskaya str. 10, Moscow, 119121, Russia. ivanov@ibmh.msk.su
Skvortsov
V S
VS
Sechenykh
A A
AA
Dubanov
A V
AV
Lisitsa
A V
AV
D000595:Amino Acid Sequence; D003198:Computer Simulation; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D012984:Software
D003577:Cytochrome P-450 Enzyme System