Electrochemical DNA sensors.
Electrochemistry-based sensors offer sensitivity, selectivity and low cost for the detection of selected DNA sequences or mutated genes associated with human disease. DNA-based electrochemical sensors exploit a range of different chemistries, but all take advantage of nanoscale interactions between the target in solution, the recognition layer and a solid electrode surface. Numerous approaches to electrochemical detection have been developed, including direct electrochemistry of DNA, electrochemistry at polymer-modified electrodes, electrochemistry of DNA-specific redox reporters, electrochemical amplifications with nanoparticles, and electrochemical devices based on DNA-mediated charge transport chemistry.
Drummond
T Gregory
TG
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Hill
Michael G
MG
Barton
Jacqueline K
JK
D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004247:DNA / Q000032:analysis* / Q000737:chemistry*; D004563:Electrochemistry / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D008567:Membranes, Artificial; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods; D011506:Proteins / Q000032:analysis*; D014159:Transducers
D020099:Coated Materials, Biocompatible; D008567:Membranes, Artificial; D011506:Proteins; D004247:DNA