Effect of lycopine on the resistance of rat liver microsomes to in vitro induced LPO.
Lycopine in concentrations of 0.5-50 microM suppressed LPO in microsomes induced by NADPH-Fe(2+) and by ascorbic acid-Fe(2+). Lycopine in a concentration of 20 microM completely prevented the decrease in the rate of benz[a]pyrene hydroxylation and activation of p-nitrophenyl-UDP-glucuronosyl transferase caused by LPO induction in microsomes.
Kravchenko
L V
LV
Institute of Nutrition, Russian Academy of Medical Sciences, Moscow.
Morozov
S V
SV
Tutel'yan
V A
VA
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D001564:Benzo(a)pyrene / Q000378:metabolism; D002338:Carotenoids / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals; D014453:Glucuronosyltransferase / Q000378:metabolism; D006900:Hydroxylation; D007501:Iron / Q000378:metabolism; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D000077276:Lycopene; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013696:Temperature
D000975:Antioxidants; D005609:Free Radicals; D001564:Benzo(a)pyrene; D002338:Carotenoids; D007501:Iron; D014453:Glucuronosyltransferase; D001205:Ascorbic Acid; D010100:Oxygen; D000077276:Lycopene