title: Minipig negative slow wave demonstrates target/nontarget differences in P300 paradigm.
abstract: The negative slow wave (NSW) is a late component of the event-related potential (ERP) in man modulated like the P300 by the stimulus, the task, and the response demand. Aiming at the development of a minipig model of schizophrenia, we investigated scalp ERPs in an auditory P300 paradigm in six Göttingen minipigs. Before training, we observed no difference between target and nontarget NSW. After training, target NSW amplitude was increased 50% compared to nontarget. A P350 was recognized, but the finding of a lack of target/nontarget difference is not conclusive.
authors.affiliation: Department of Psychiatry, H:S Bispebjerg Hospital, University Hospital of Copenhagen, Copenhagen, Denmark. s.arnfred@tdcadsl.dk
authors.forename: Sidse Marie
authors.initials: SM
authors.lastname: Arnfred
authors.forename: Nanna Marie
authors.initials: NM
authors.lastname: Lind
authors.forename: Anette
authors.initials: A
authors.lastname: Moustgaard
authors.forename: Axel Kornerup
authors.initials: AK
authors.lastname: Hansen
authors.forename: Albert
authors.initials: A
authors.lastname: Gjedde
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D004193:Discrimination Learning / Q000502:physiology; D004192:Discrimination, Psychological / Q000502:physiology; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology; D008297:Male; D013552:Swine; D013556:Swine, Miniature