title: [28-Year-Old Patient with Elevated Serum IgE Levels and Multiple Refractory Epidural and Paravertebral Abscesses. Clinical manifestation of a Job's Syndrome?].
abstract: BACKGROUND
  The hyper-IgE syndrome is a rare primary immunodeficiency characterized by recurrent staphylococcal infections and high levels of serum IgE.
  
  
  METHODS
  The case of a 28-year-old man with epidural and paravertebral abscesses and a markedly elevated serum IgE level of 2,609 U/ml is reported. There was no allergic diathesis, nor had the patient a history of other diseases, which might explain the high serum IgE level. In a blood culture, Staphylococcus aureus was detected. Since early childhood, the patient has suffered from recurrent skin infections.
  
  
  CONCLUSIONS
  The presented study case discusses the diagnosis of a Job's syndrome in this patient and reviews previously published cases. It also summarizes the current knowledge about pathogenesis and diagnostic criteria of this rare syndrome.
authors.affiliation: Klinik und Poliklinik für Innere Medizin I, Universitätsklinikum Regensburg, Regensburg. KATINKA.PLIKAT@ KLINIK.UNI-R.DE
authors.forename: Katharina
authors.initials: K
authors.lastname: Plikat
authors.forename: Thomas
authors.initials: T
authors.lastname: Glück
authors.forename: Markus
authors.initials: M
authors.lastname: Völk
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schölmerich
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000904:Antibiotics, Antitubercular / Q000008:administration & dosage / Q000627:therapeutic use; D002437:Cefazolin / Q000008:administration & dosage / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004322:Drainage; D005500:Follow-Up Studies; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007589:Job Syndrome / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D008297:Male; D016659:Psoas Abscess / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000601:surgery; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy; D013997:Time Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D007073:Immunoglobulin E; D002437:Cefazolin; D012293:Rifampin