title: Vaccinia virus motility.
abstract: Vaccinia virus (VV), the virus smallpox vaccine, replicates in the cytoplasm of infected cells. The intracellular movement of this large virus would be inefficient without specific transport mechanisms; therefore, VV uses microtubules for movement during both entry and egress. In addition, the dissemination of virus from infected cells to adjacent cells is promoted by the polymerization of actin beneath cell surface virions to drive virus particles away from the cell. Last, the roles of different VV particles in virus movement within and between hosts are discussed.
authors.affiliation: Department of Virology, The Wright-Fleming Institute, Faculty of Medicine, Imperial College London, St. Mary's Campus, Norfolk Place, London W2 1PG, United Kingdom. glsmith@imperial.ac.uk
authors.forename: Geoffrey L
authors.initials: GL
authors.lastname: Smith
authors.forename: Brendan J
authors.initials: BJ
authors.lastname: Murphy
authors.forename: Mansun
authors.initials: M
authors.lastname: Law
mesh_terms: D001692:Biological Transport / Q000502:physiology; D012900:Smallpox Vaccine; D014615:Vaccinia / Q000821:virology; D014616:Vaccinia virus / Q000254:growth & development / Q000502:physiology*; D014764:Viral Proteins / Q000502:physiology; D019065:Virus Assembly / Q000502:physiology
chemical_list: D012900:Smallpox Vaccine; D014764:Viral Proteins