title: Commercial-scale synthesis of protected 2'-deoxycytidine and cytidine nucleosides.
abstract: Transformation of 2'-deoxyuridine and uridine analogs to protected 2'-deoxycytidine and cytidine analogs has been investigated by two different methods. First, traditional triazolation protocol and second p-nitrophenoxylation method. Our studies conclude that the triazolation method is better and suitable for commercial scale-up.
authors.affiliation: Research and Development, Innovasynth Technologies (India) Limited, (Formerly a Division of Indian Organic Chemicals Limited), Khopoli District, Raigad, Maharashtra, India. divakj@yahoo.com
authors.forename: Kikkeri J
authors.initials: KJ
authors.lastname: Divakar
authors.forename: Chitra M
authors.initials: CM
authors.lastname: Sawant
authors.forename: Y A
authors.initials: YA
authors.lastname: Mulla
authors.forename: Deepak V
authors.initials: DV
authors.lastname: Zemse
authors.forename: Sakina M
authors.initials: SM
authors.lastname: Sitabkhan
authors.forename: Bruce S
authors.initials: BS
authors.lastname: Ross
authors.forename: Yogesh S
authors.initials: YS
authors.lastname: Sanghvi
mesh_terms: D003562:Cytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008968:Molecular Conformation; D014230:Triazoles
chemical_list: D007202:Indicators and Reagents; D014230:Triazoles; D003841:Deoxycytidine; D003562:Cytidine