title: Nephrogenic rests mimicking Wilms' tumor on CT.
abstract: Nephrogenic rests (NR) are persistent benign remnants of embryonic renal tissue. A small percentage of these may develop into Wilms' tumor (WT). Radiologic imaging is relied upon to differentiate between these entities, with the hallmark of malignant transformation being growth on serial imaging studies. There is, however, considerable overlap in their imaging characteristics. The authors present a case of two biopsy-proven NR in a 2-year-old girl with sporadic aniridia that were indistinguishable from WT on initial radiologic studies. One of the NR grew on serial imaging studies mimicking a WT, but after resection was confirmed to be a benign hyperplastic NR on pathologic examination.
authors.affiliation: Russell H. Morgan Department of Radiology, The Johns Hopkins Hospital and School of Medicine, 600 N. Wolfe St., Baltimore, MD 21287, USA., subhas_n@yahoo.com
authors.forename: Naveen
authors.initials: N
authors.lastname: Subhas
authors.forename: Pedram
authors.initials: P
authors.lastname: Argani
authors.forename: John P
authors.initials: JP
authors.lastname: Gearhart
authors.forename: Stanley S
authors.initials: SS
authors.lastname: Siegelman
mesh_terms: D002471:Cell Transformation, Neoplastic; D002675:Child, Preschool; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D007668:Kidney / Q000002:abnormalities / Q000000981:diagnostic imaging*; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D009396:Wilms Tumor / Q000000981:diagnostic imaging*