title: [Sildenafil as a substitute for subcutaneous prostacyclin in pulmonary hypertension].
abstract: Subcutaneous prostacyclin (treprostinil) is an effective short-term treatment for pulmonary hypertension. The most frequently described adverse effect-pain in the area of injection-rarely requires that treatment be withdrawn. Sildenafil is a selective fosfodiesterase-5 inhibitor with pulmonary vasodilating effects. We describe the use of sildenafil as a substitute for treprostinil in a patient with pulmonary hypertension associated with lupus erythematosus. Treatment with treprostinil was discontinued due to uncontrollable abdominal pain.
authors.affiliation: Unidad de Hipertensión Pulmonar, Insuficiencia Cardíaca y Trasplante Cardíaco. Servicio de Cardiología. Hospital Universitario 12 de Octubre. Madrid. España. med022585@saludalia.com
authors.forename: L
authors.initials: L
authors.lastname: Cea-Calvo
authors.forename: P
authors.initials: P
authors.lastname: Escribano Subías
authors.forename: R
authors.initials: R
authors.lastname: Tello de Menesses
authors.forename: M A
authors.initials: MA
authors.lastname: Gómez Sánchez
authors.forename: J F
authors.initials: JF
authors.lastname: Delgado Jiménez
authors.forename: C
authors.initials: C
authors.lastname: Sáenz de la Calzada
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced; D000328:Adult; D011464:Epoprostenol / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D014665:Vasodilator Agents / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate; D011464:Epoprostenol; C427248:treprostinil