title: [Relationship between the expression of IL-10 and liver regeneration following reduced-size orthotopic liver transplantation in rats].
abstract: OBJECTIVE
  To explore the relationship between the expression of IL-10 and liver regeneration following reduced-size orthotopic liver transplantation in rats.
  
  
  METHODS
  Rats models with reduced-size orthotopic liver transplantation were established. The rats were divided in three groups: partial liver resection (I), orthotopic liver transplantations (II), and reduced-size orthotopic liver transplantation (III). The expression of IL-10 and regenerative response of liver in rats were evaluated by immunohistochemistry and flow cytometry on the 1st, 2nd, 4th and 7th days after the operations, respectively.
  
  
  RESULTS
  The liver grafts were capable of regeneration, the proliferation activity peaked on the fourth day with 26.3+/-0.9, 35.8+/-2.2, and 32.4+/-1.8 in I, II, and III groups, respectively. The expression of IL-10 was negative correlation to liver regeneration (r=-0.58, P<0.01).
  
  
  CONCLUSIONS
  Whole and reduced-size transplanted livers show the same regenerative activity. The maximal regenerative response delayes slightly, compared with that after partial hepatectomy. IL-10 plays an important immunomodulatory role in liver regeneration,and the effect is affected by general immune system and other cytokines.
authors.affiliation: Liver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Cheng
authors.forename: Xiang-cheng
authors.initials: XC
authors.lastname: Li
authors.forename: Xue-hao
authors.initials: XH
authors.lastname: Wang
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Qian
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
mesh_terms: D000818:Animals; D005434:Flow Cytometry; D007150:Immunohistochemistry; D016753:Interleukin-10 / Q000032:analysis*; D008099:Liver / Q000737:chemistry*; D008115:Liver Regeneration; D016031:Liver Transplantation; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016753:Interleukin-10