Synthesis and antitumor activity of N-sulfonyl derivatives of nucleobases and sulfonamido nucleoside derivatives.
The introduction of sulfonamido group on the C-2 position of pyrimidine nucleosides was achieved by ring opening of 2,2'- and 2,3'-anhydronucleosides. N-sulfonyl derivatives of nucleobases and sulfonamido derivatives of nucleosides were assayed for in vitro antitumor activity.
Zinić
B
B
Ruder Bosković Institute, Zagreb, Croatia. bzinic@rudjer.irb.hr
Krizmanić
I
I
Glavas-Obrovac
Lj
Lj
Karner
I
I
Zinić
M
M
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D005472:Fluorouracil / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007700:Kinetics; D015394:Molecular Structure; D009705:Nucleosides / Q000494:pharmacology*; D011684:Purine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D009705:Nucleosides; D011684:Purine Nucleosides; D011741:Pyrimidine Nucleosides; D013449:Sulfonamides; D005472:Fluorouracil