A generic biokinetic model for predicting the behaviour of the lanthanide elements in the human body.
Information on the biokinetics of the 15 elements of the lanthanide series, 57La to 71Lu, is too sparse to permit individual development of meaningful biokinetic models to describe the behaviour of each of the elements in humans. The lanthanides show a regular gradation in chemical properties across the series, and animal studies indicate that this is reflected in regular differences in their deposition in tissues such as the liver and skeleton. These regular differences in chemical and biological behaviour have been utilised to construct a generic lanthanide biokinetic model and to define element-specific parameters for each element in the series. This report describes the use of the available biokinetic data for humans and animals to derive the parameters for each of the elements.
Taylor
D M
DM
Department of Chemistry, Cardiff University, PO Box 912, Cardiff CF10 3TB, Wales, UK. davtay@globalnet.co.uk
Leggett
R W
RW
D000818:Animals; D001822:Body Burden; D001842:Bone and Bones / Q000378:metabolism; D003198:Computer Simulation; D006801:Humans; D007668:Kidney / Q000378:metabolism; D028581:Lanthanoid Series Elements / Q000032:analysis / Q000097:blood* / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D009928:Organ Specificity; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D051381:Rats; D013045:Species Specificity; D014018:Tissue Distribution; D014915:Whole-Body Counting / Q000379:methods*
D028581:Lanthanoid Series Elements