Profiling gene expression in kidney development.
Insights into the normal development of the kidney have been derived from metanephric organ cultures, knockout mice and the later definition of the responsible single genetic abnormalities in some human congenital renal tract malformations. Deciphering of the human genome and the ability to examine multiple messenger RNA has opened new vistas and the capacity to begin to understand the complex kidney developmental process. In this review we focus on recent large-scale gene expression profiles performed during normal murine and human nephrogenesis and suggest how they might provide insights into normal kidney development as well as aberrations of this normal process that may result in renal dysplasia or pediatric renal malignancy (Wilms' tumor).
Dekel
Benjamin
B
Developmental Biology Laboratory, Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel. bmdekel@wicc.weizmann.ac.il
D000818:Animals; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007668:Kidney / Q000196:embryology* / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000235:genetics*; D051379:Mice; D009024:Morphogenesis; D020411:Oligonucleotide Array Sequence Analysis