Can genetic material retrotransposition be a cause of pathology accompanying cerebral aneurysm rupture?
Our considerations were prompted by observation of patients who underwent surgery due to cerebral aneurysm rupture. Elevated anti-HIV antibody titers were detected in such patients. The above condition was not observed either in subjects with intracranial hemorrhages from cerebral angiomas. The observed titers remained certainly below the cut off level indicating contact with HIV. We analyzed the subpopulations of peripheral blood lymphocytes both in the surgery patients and in the control group represented by blood collected from blood donors. On the other hand, the proliferation potential of circulating lymphocytes in the blood of patients with subarachnoid hemorrhages due to cranial aneurysm ruptures was found to be decreased. Dislocation of transposons, so-called 'unauthorized recombination' is known to occur within the framework of genetic code pathology. Endogenous human viruses have been described, and they may be involved in the development of autoimmune disorders. Additionally, viruses involved in autoimmune processes, which may be 'identical' with retrotransposons, have been described. Moreover, there are studies demonstrating that AIDS is caused by retrotransposition of genetic code material fragments. Our considerations are substantiated by ultrastructural analyses of material coming from the gyrus rectus cortex fragments, resected in patients who underwent clipping of a ruptured aneurysm of the anterior communicating artery. We demonstrated in neuronal chromatin the presence of a molecule ca. 80 nm in diameter, corresponding with its size to retroviruses or genetic material molecules with altered substructure. The authors suggest a new mechanism of development of neurological deficits in patients with ruptured cerebral aneurysms.
Ryba
Mirosław S
MS
Department of Neurosurgery, Medical Research Center, Polish Academy of Sciences, Warsaw, Poland. rybam@cmdik.pan.pl
Andrychowski
Jarosław
J
Dabrowska
Julia
J
D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics; D000328:Adult; D000368:Aged; D000783:Aneurysm; D017542:Aneurysm, Ruptured / Q000235:genetics*; D002455:Cell Division; D002843:Chromatin / Q000378:metabolism; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000235:genetics*; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000378:metabolism; D011995:Recombination, Genetic; D018626:Retroelements / Q000235:genetics*; D013345:Subarachnoid Hemorrhage / Q000235:genetics
D002843:Chromatin; D018626:Retroelements