Effects of san qi on gastric secretion and protective factors of gastric mucosa in the rat with precancerous lesion of stomach.
In the model rat with precancerous lesion of stomach induced by the combined method of insertion of a spring into the pylorus and high salt hot paste, effects of San Qi ([symbol: see text] Radix Notoginseng) on gastric secretion and protective factors of stomach were investigated. The results indicated that gastric secretion, gastric mucosal blood flow (GMBF) and aminohexose content lowered significantly, and malondialdehyde (MDA) increased significantly (P < 0.01) in the model group as compared with the normal group; after treatment with San Qi Powder for 12 weeks, both gastric secresion and GMBF increased, and MDA content decreased as compared with the negative control group (P < 0.01), with no significant increase of aminohexose content. It is suggested that San Qi ([symbol: see text] Radix Notoginseng) may improve gastric secretion, and that increase of GMBF and antagonism against the lesion of oxygen free radicals are possibly one of its mechanisms.
Shi
Xueying
X
Dongzhimen Hospital, Beijing University of Traditional Chinese Medicine, Beijing 100700.
Zhao
Fengzhi
F
Dai
Xin
X
Dong
Xiuyun
X
Fang
Jie
J
Yang
Huimin
H
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005753:Gastric Mucosa / Q000098:blood supply / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D005894:Panax; D011230:Precancerous Conditions / Q000098:blood supply / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow; D013274:Stomach Neoplasms / Q000098:blood supply / Q000503:physiopathology*
D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde