Hepatoprotection via the IL-6/Stat3 pathway.
Stat3 is a vital transcription factor that is activated downstream of the gp130 receptor, primarily via IL-6 signaling in adult liver. A new study demonstrates that Stat3 provides hepatoprotection against Fas-mediated apoptotic liver damage by two mechanisms: direct inactivation of caspases and reduction of reactive oxygen species.
Taub
Rebecca
R
Bristol-Myers Squibb Co., PO Box 5100, 5 Research Parkway, Wallingford, Connecticut 06492, USA. rebecca.taub@bms.com
D000818:Animals; D017209:Apoptosis; D002470:Cell Survival; D019610:Cytoprotection; D004268:DNA-Binding Proteins / Q000502:physiology*; D015850:Interleukin-6 / Q000502:physiology*; D008099:Liver / Q000473:pathology*; D008115:Liver Regeneration; D051379:Mice; D010084:Oxidation-Reduction; D050796:STAT3 Transcription Factor; D015398:Signal Transduction; D015534:Trans-Activators / Q000502:physiology*; D019014:fas Receptor / Q000502:physiology*
D004268:DNA-Binding Proteins; D015850:Interleukin-6; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; D015534:Trans-Activators; D019014:fas Receptor