title: A new tiazofurin pronucleotide: synthesis and biological evaluation of cyclosaligenyl-tiazofurin monophosphate.
abstract: Synthesis and biological activities of cyclosaligenyl-tiazofurin monophosphate (CycloSal-TRMP), a new tiazofurin pronucleotide, are reported. CycloSal-TRMP proved to be active in vitro against human myelogenous leukemia K562 cell line and as A1 adenosine receptor agonist.
authors.affiliation: Department of Chemical Sciences, University of Camerino, Camerino, MC, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Cappellacci
authors.forename: G
authors.initials: G
authors.lastname: Barboni
authors.forename: P
authors.initials: P
authors.lastname: Franchetti
authors.forename: C
authors.initials: C
authors.lastname: Martini
authors.forename: H N
authors.initials: HN
authors.lastname: Jayaram
authors.forename: M
authors.initials: M
authors.lastname: Grifantini
mesh_terms: D058916:Adenosine A1 Receptor Antagonists; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020014:K562 Cells; D010710:Phosphates / Q000138:chemical synthesis / Q000494:pharmacology; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D058916:Adenosine A1 Receptor Antagonists; D000970:Antineoplastic Agents; D010710:Phosphates; D011355:Prodrugs; D012254:Ribavirin; C033706:tiazofurin