title: GC-MS quantitation of fragrance compounds suspected to cause skin reactions. 1.
abstract: Recent changes in European legislation require monitoring of 24 volatile compounds in perfumes as they might elicit skin sensitization. This paper reports a GC-MS quantitation procedure for their determination in fragrance concentrates. GC and MS conditions were optimized for a routine use: analysis within 30 min, solvent and internal standard selection, and stock solution stability. Calibration curves were linear in the range of 2-100 mg/L with coefficients of determination in excess of 0.99. The method was tested using real perfumes spiked with known amounts of reference compounds.
authors.affiliation: Analytical Working Group of the International Fragrance Association (IFRA), Square Marie-Louise 49, B-1000 Brussels, Belgium. alain.chaintreau@firmenich.com
authors.forename: Alain
authors.initials: A
authors.lastname: Chaintreau
authors.forename: Daniel
authors.initials: D
authors.lastname: Joulain
authors.forename: Christophe
authors.initials: C
authors.lastname: Marin
authors.forename: Claus-Oliver
authors.initials: CO
authors.lastname: Schmidt
authors.forename: Matthias
authors.initials: M
authors.lastname: Vey
mesh_terms: D000485:Allergens / Q000032:analysis*; D003877:Dermatitis, Contact / Q000209:etiology*; D008401:Gas Chromatography-Mass Spectrometry; D010476:Perfume / Q000737:chemistry*; D011786:Quality Control; D012997:Solvents; D014835:Volatilization
chemical_list: D000485:Allergens; D010476:Perfume; D012997:Solvents