[Seroprevalence of Helicobacter pylori infection and anti-CagA positivity in the county Szabolcs-Szatmár-Bereg].
The authors studied the seroprevalence of Helicobacter pylori infection and the risk factors for infection, among adult volunteers from Szabolcs-Szatmár-Bereg county, East Hungary in year 2000. Sera were collected from 756 adults (328 males, 428 females, m/f = 1.5:2; mean age 42.4 yrs.; range 18-69 yrs.). Anti-Helicobacter pylori IgG and anti-CagA IgG antibodies were identified serologically using a sensitive ELISA technique. A questionnaire was completed to obtain necessary informations. The overall rate of seropositivity was 58.6% (45.2% in those aged 18-29 and 69.6% in those aged 50-59). Seropositivity was significantly higher in rural population than in urban area (p < 0.001), sharing a bed (p < 0.001), if parents were manual workers (p < 0.001), between keepers of cat (p < 0.005). The authors found a significant inverse correlation between Helicobacter pylori infection and educational level (p < 0.001), income (p < 0.005), absence of water supply and sanitation (childhood: p < 0.001, adulthood: p < 0.05). There were no significant differences in Helicobacter pylori infection related to gender, subject's occupation, smoking and drinking habits, gastric symptoms, family history of ulcer or gastric cancer. 67.5% of Helicobacter pylori positives were anti-CagA positives too. Helicobacter pylori positivity is higher than in developed countries, and than in the more developed county Vas.
Iszlai
Eva
E
Jósa András Megyei Kórház, II. Belgyógyászat, Gasztroenterológiai Részleg, Nyíregyháza.
Kiss
Endre
E
Toldy
Erzsébet
E
Agoston
Sándor
S
Sipos
Béla
B
Vén
László
L
Rácz
Ferenc
F
Szerafin
Laszló
L
D000328:Adult; D000368:Aged; D000942:Antigens, Bacterial / Q000097:blood*; D001426:Bacterial Proteins / Q000097:blood*; D004522:Educational Status; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D009790:Occupations; D016017:Odds Ratio; D012424:Rural Population / Q000706:statistics & numerical data; D012499:Sanitation; D012959:Socioeconomic Factors; D014505:Urban Population / Q000706:statistics & numerical data
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D007074:Immunoglobulin G; C080866:cagA protein, Helicobacter pylori