title: The influence of diabetes mellitus on the practice and outcomes of percutaneous coronary intervention in the community: a report from the HCA database.
abstract: BACKGROUND
  Diabetics remain a high-risk group for those undergoing percutaneous coronary intervention (PCI) using balloon angioplasty and/or intracoronary stents for myocardial revascularization. The objective of this study is to compare clinical characteristics, demographics, procedure indications, lesion characteristics, and acute and long-term outcomes between diabetic patients and non-diabetic patients in a community based PCI registry.
  
  
  RESULTS
  Information on patient demographics, coronary risk factors, lesion characteristics, procedures, and outcomes were derived from an HCA, Inc. database on all patients undergoing a PCI procedure in one of four community cardiac catheterization laboratories (CCL). A total of 3,139 patients who underwent PCI procedures from July 1, 1999 through September 30, 2000 were enrolled in this study. Approximately one-third of these patients completed a follow-up survey one year after their initial encounter. Analysis was limited to those patients undergoing PCI of native vessels with stents or conventional balloon angioplasty; patients with target lesions in bypass grafts or those treated with atherectomy were excluded. Approximately 23.5% of the patients enrolled in the study were diabetic. This study found no significant difference in any acute outcome between diabetic and non-diabetic patients in the hospital episode associated with the index PCI procedure. However, data from the 1-year follow-up survey indicates diabetic patients tended to have more target lesion revascularization (TLR) (13.6% versus 8.9%; p = 0.07) and more target vessel revascularization (TVR) (17.6% versus 12.7%; p = 0.058) than non-diabetic patients. In addition, adjusted odds ratios indicate that diabetic patients were 1.6 times more likely to have a second PCI procedure in another vessel (p = 0.013), 2.4 times more likely to undergo bypass surgery (p = 0.003), 1.9 times more likely to undergo an additional revascularization procedure (p < 0.001) and 1.8 times more likely to experience any major adverse cardiac events (p < 0.001) than non-diabetic patients during the follow-up period.
  
  
  CONCLUSIONS
  This study indicates that selected diabetic patients can be treated for myocardial revascularization using PCI procedures with acceptable acute outcomes. However, diabetic patients undergoing PCIs have significantly more disease progression and are more likely to experience the need for recurrent revascularization.
authors.affiliation: Cardiovascular Division, Henry Ford Hospital, Detroit, Michigan 48202, USA.
authors.forename: Aaron D
authors.initials: AD
authors.lastname: Kugelmass
authors.forename: David J
authors.initials: DJ
authors.lastname: Cohen
authors.forename: Frank
authors.initials: F
authors.lastname: Houser
authors.forename: Michael
authors.initials: M
authors.lastname: Mack
authors.forename: April W
authors.initials: AW
authors.lastname: Simon
authors.forename: Salvatore L
authors.initials: SL
authors.lastname: Battaglia
authors.forename: Lynn G
authors.initials: LG
authors.lastname: Tarkington
authors.forename: Edmund R
authors.initials: ER
authors.lastname: Becker
authors.forename: Steven D
authors.initials: SD
authors.lastname: Culler
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D003324:Coronary Artery Disease / Q000150:complications / Q000628:therapy*; D016208:Databases, Factual; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011364:Professional Practice; D012042:Registries; D012111:Residence Characteristics; D015607:Stents; D016896:Treatment Outcome