title: Synthesis and biological evaluation of some acyclic 4,6-disubstituted 1H-pyrazolo[3,4-d]pyrimidine nucleosides.
abstract: The chemical synthesis and biological evaluation of some acyclic alpha-[6-(1'-carbamoylalkylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]thioalkylamide nucleosides are described.
authors.affiliation: Laboratoire de Chimie Bio-Organique, Faculté des Sciences, Agadir, Morocco.
authors.forename: O
authors.initials: O
authors.lastname: Moukha-chafiq
authors.forename: M L
authors.initials: ML
authors.lastname: Taha
authors.forename: A
authors.initials: A
authors.lastname: Mouma
authors.forename: H B
authors.initials: HB
authors.lastname: Lazrek
authors.forename: J J
authors.initials: JJ
authors.lastname: Vasseur
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003587:Cytomegalovirus / Q000187:drug effects; D014645:Herpesvirus 3, Human / Q000187:drug effects; D006801:Humans; D007202:Indicators and Reagents; D008958:Models, Molecular; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D007202:Indicators and Reagents; D009705:Nucleosides; D011720:Pyrazoles; D011725:Pyridines; C447480:pyrazolo(3,4-b)pyridine