A relationship between Matrix metalloproteinase-1 (MMP-1) promoter polymorphism and cervical cancer progression.
Single nucleotide polymorphism (SNP) of the promoter region of MMP-1 (at -1607 bp) creates Ets binding sites, and correlations between this SNP and cancer susceptibility have been reported for various cancers. In this study, we genotyped the SNP in 23 cervical intraepithelial neoplasias (CIN) and 86 cervical cancer specimens. We found a correlation between promoter polymorphism and MMP-1 expression, and that this SNP was correlated with the clinical stage of cervical cancer. These findings suggested that SNP of MMP-1 promoter might influence the ability in cervical cancer invasion via transcriptional activity of this gene.
Nishioka
Yoshihiro
Y
Department of Obstetrics and Gynecology, Sapporo Medical University, School of Medicine, South-1, West-16, Chuo-ku, Sapporo, 060-0061, Hokkaido, Japan.
Sagae
Satoru
S
Nishikawa
Akira
A
Ishioka
Shin ichi
Si
Kudo
Ryuichi
R
D001483:Base Sequence; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D020781:Matrix Metalloproteinase 1 / Q000032:analysis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D014407:Tumor Cells, Cultured; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000235:genetics* / Q000473:pathology
D020781:Matrix Metalloproteinase 1