title: An evaluation of forward and inverse radiotherapy planning using Helax-TMS (version 6.0) for lung cancer patients treated with RTOG 93-11 dose-escalation protocol.
abstract: This study investigated the dosimetric advantages of inversely planned intensity-modulated radiotherapy (IMRT) over forward-planned conventional 3D conformal radiotherapy (3D-CRT) in treating lung cancer patients at escalated dose. Three consecutively accrued patients on the RTOG 93-11 dose-escalation protocol were replanned using IMRT with the same dosimetric rules, so that the isodose distributions and dose-volume histograms could be generated and compared. The Helax-TMS treatment planning system, with an IMRT optimization module (version 6.0), was used. In all cases, a consistent approach of inverse planning and set of dose-volume constraints (DVCs) provided improved critical structure sparing. However, the minimum dose in PTV was generally below that achieved with the corresponding forward planned 3D-CRT.
authors.affiliation: Department of Medical Physics, Cross Cancer Institute, Edmonton, Alberta, Canada.
authors.forename: Lori J
authors.initials: LJ
authors.lastname: Underwood
authors.forename: Brad R
authors.initials: BR
authors.lastname: Murray
authors.forename: Donald M
authors.initials: DM
authors.lastname: Robinson
authors.forename: G Colin
authors.initials: GC
authors.lastname: Field
authors.forename: Wilson H
authors.initials: WH
authors.lastname: Roa
mesh_terms: D000465:Algorithms; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D020266:Radiotherapy, Conformal