Dynamic multivalent lactosides displayed on cyclodextrin beads dangling from polymer strings.
[reaction: see text] Lactose-appended cyclodextrin derivatives have been synthesized and threaded onto hydrophobic polymers in aqueous solution to form dynamic multivalent lactosides for binding to lectins. The threading process, which proceeds quickly, can be observed by one- and two-dimensional NMR spectroscopies.
Nelson
Alshakim
A
California NanoSystems Institute and the Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, California 90095, USA.
Stoddart
J Fraser
JF
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D003505:Cyclodextrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D006027:Glycosides / Q000737:chemistry*; D037102:Lectins / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D011108:Polymers / Q000737:chemistry*; D013816:Thermodynamics
D003505:Cyclodextrins; D006027:Glycosides; D037102:Lectins; D011108:Polymers; C008245:lactosides