Use of esters of N-hydroxysuccinimide in the synthesis of N-acylamino acids.
Several crystalline N-hydroxysuccinimide esters of short- and long-chain fatty acids have been synthesized. These compounds react with free amino acids to form preferentially N-acylamino acids. The reaction of the N-hydroxysuccinimide esters with hydroxylamine and the behavior of the N-acylamino acids on thin-layer chromatography are described.
Lapidot
Y
Y
Department of Biological Chemistry, The Hebrew University of Jerusalem, Israel.
Rappoport
S
S
Wolman
Y
Y
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002855:Chromatography, Thin Layer; D004951:Esterification; D005227:Fatty Acids / Q000737:chemistry; D007850:Lauric Acids / Q000737:chemistry; D013388:Succinimides / Q000737:chemistry
D000596:Amino Acids; D005227:Fatty Acids; D007850:Lauric Acids; D013388:Succinimides; C030358:lauric acid