title: [Hypothyroidism in dizygotic premature twins due to excessive prepartal vaginal iodine application].
abstract: In dizygotic premature twins delivered by Caesarean section after prolonged efforts to effect premature birth we found markedly enhanced thyroid stimulating hormone levels. The mother had been subjected to local polyvidone iodine therapy for seven weeks with PVP suppositories to prevent vaginal infections. Control checks revealed persistently elevated TSH levels, whereas T3/T4 levels were always reduced. Greatly pronounced iodine excretion was seen in the urine of both the babies. This raised the suspicion of iodine-induced hypothyroidism in both children. Substitution with 1-thyroxine was initiated and a withdrawal trial performed after 12 weeks. The patients remained euthyroid after the treatment had been discontinued. Due to possible transfer of iodide to the fetus associated with the risk of iodine-induced hypothyroidism, it is recommended to abstain from vaginal application of iodine during pregnancy.
authors.affiliation: Klinik für Kinder- und Jugendmedizin, Klinikum Neukölln, Berlin. k.kinderklinik@vivantes.de
authors.forename: S
authors.initials: S
authors.lastname: Müther
authors.forename: H
authors.initials: H
authors.lastname: Krude
authors.forename: R
authors.initials: R
authors.lastname: Jäger
authors.forename: W
authors.initials: W
authors.lastname: Rhode
authors.forename: A
authors.initials: A
authors.lastname: Grüters
authors.forename: R
authors.initials: R
authors.lastname: Rossi
mesh_terms: D002585:Cesarean Section; D003409:Congenital Hypothyroidism; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced / Q000000981:diagnostic imaging*; D007231:Infant, Newborn; D007455:Iodine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013488:Suppositories; D013972:Thyrotropin; D014429:Twins, Dizygotic; D016216:Ultrasonography, Prenatal; D014623:Vaginal Diseases / Q000517:prevention & control
chemical_list: D013488:Suppositories; D013972:Thyrotropin; D007455:Iodine