title: Faster oxygen uptake kinetics at the onset of submaximal cycling exercise following 4 weeks recombinant human erythropoietin (r-HuEPO) treatment.
abstract: We tested the hypothesis that prolonged administration of moderate doses of recombinant human erythropoietin (r-HuEPO) accelerates the initial rate of rise in pulmonary O2 uptake (VO2) in response to submaximal exercise and increases the maximal rate of O2 uptake (VO(2,max)). Sixteen endurance-trained athletes were divided into two groups: r-HuEPO- (n=9) or placebo-treated (n=7). r-HuEPO or placebo (saline) injections were given s.c. 3 times a week for 4 weeks. Exercise testing, before and after the 4 weeks, comprised incremental maximal tests and several transitions from rest to 10-min cycling exercise at 65% VO(2,max). VO2 was measured breath-by-breath during all tests. In the r-HuEPO group, resting haemoglobin concentration (+9.6%) and haematocrit (+8.3%), as well as VO(2,max) (+7.0%) and power output (+7.2%) increased significantly (P<0.05) after the 4 weeks, whereas no change was observed in the control group. The time constant of the primary VO2 response was significantly faster (+18%) after the 4 weeks r-HuEPO treatment than before (mean+/-SD; 29.3+/-4.5 vs. 35.7+/-7.4 s, respectively, P<0.05) but was unaffected in the placebo group (34.5+/-7.3 vs. 33.4+/-7.9 s). Collectively, our findings suggest that r-HuEPO contributes both to an acceleration of the dynamic response of VO2 to submaximal exercise and to an increase in maximal exercise capacity.
authors.affiliation: UPRES EA 2991, Laboratoire Sport Performance Santé, Faculté des Sciences du Sport, Université Montpellier 1, 34090 Montpellier, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Connes
authors.forename: Stéphane
authors.initials: S
authors.lastname: Perrey
authors.forename: Alain
authors.initials: A
authors.lastname: Varray
authors.forename: Christian
authors.initials: C
authors.lastname: Préfaut
authors.forename: Corinne
authors.initials: C
authors.lastname: Caillaud
mesh_terms: D000328:Adult; D001642:Bicycling / Q000502:physiology*; D004334:Drug Administration Schedule; D004921:Erythropoietin / Q000008:administration & dosage*; D005080:Exercise Test; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007700:Kinetics; D010101:Oxygen Consumption / Q000187:drug effects*; D010807:Physical Endurance / Q000187:drug effects; D011994:Recombinant Proteins; D013997:Time Factors
chemical_list: D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin