Preparation of 3-acetoacetylaminobenzo[b]furan derivatives with cysteinyl leukotriene receptor 2 antagonistic activity.
Novel 3-acetoacetylaminobenzo[b]furan derivatives with a modified triene system at the 3-position were prepared through acylation of the 3-aminobenzo[b]furans with 5-methylisoxazole-4-carboxylic acid chloride followed by basic cleavage of the isoxazole ring and several of these compounds showed moderate cysteinyl leukotriene receptor 2 antagonistic activity.
Tsuji
Eriko
E
School of Pharmaceutical Sciences, Mukogawa-Women's University, 11-68 Koshien Kyuban-cho, Nishinomiya 663-8179, Japan.
Ando
Kumiko
K
Kunitomo
Jun-ichi
J
Yamashita
Masayuki
M
Ohta
Shunsaku
S
Kohno
Shigekatsu
S
Ohishi
Yoshitaka
Y
D001249:Asthma / Q000188:drug therapy; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D002625:Chemistry, Organic / Q000379:methods*; D018360:Crystallography, X-Ray; D006801:Humans; D020024:Leukotriene Antagonists; D008565:Membrane Proteins; D008956:Models, Chemical; D008958:Models, Molecular; D018077:Receptors, Leukotriene
D001572:Benzofurans; D020024:Leukotriene Antagonists; D008565:Membrane Proteins; D018077:Receptors, Leukotriene; C412375:cysteinyl leukotriene receptor 2; C105430:benzofuran