title: Effects of sulphate- and bicarbonate-rich mineral waters on net and fractional intestinal absorption and urinary excretion of magnesium in rats.
abstract: Magnesium (Mg) intake is below the recommended daily allowances in many developed countries. Mg-rich mineral waters can provide significant amounts of energy-free Mg and thus help to meet Mg requirements. We assessed the effects of different Mg-rich mineral waters on overall intestinal Mg absorption and urinary Mg excretion in 40 rats split into four groups: one received distilled water, another a solution of MgCl(2) and the others two different mineral waters, sulphated water (Hépar) and carbonated water (Badoit) mixed with the diet and as drinking water, for four weeks. The rats were given 3 mg of (26)Mg orally and 0.5 mg of (25)Mg intravenously. They were placed in metabolic cages, and diet consumption, and faeces and urine excretion were monitored during the last four days of the experiment. The rats were then sacrificed and blood was sampled. Mg levels in the diet, faeces, urine and biological samples were measured by atomic absorption spectrometry. Mg stable isotope measurements were performed by ICP/MS. Mg-rich mineral waters significantly increased net intestinal absorption of Mg by more than 30%, but the proportions of both apparent and true intestinal absorption of Mg were similar in all four groups. Thus, net and fractional retention of Mg were similar in the three Mg-supplemented groups. In conclusion, both types of Mg-rich mineral waters studied similarly increased both absorption and urinary excretion of Mg with no positive effect on the overall retention of Mg, probably because the Mg status of the rats was already satisfactory.
authors.affiliation: Centre de Recherche en Nutrition Humaine d'Auvergne, Unité Maladies Métaboliques & Micronutriments INRA, Theix, 63122, St Genès Champanelle, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Feillet-Coudray
authors.forename: Sophie
authors.initials: S
authors.lastname: Lafay
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Tressol
authors.forename: Elyett
authors.initials: E
authors.lastname: Gueux
authors.forename: André
authors.initials: A
authors.lastname: Mazur
authors.forename: Charles
authors.initials: C
authors.lastname: Coudray
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects* / Q000502:physiology; D007554:Isotopes / Q000493:pharmacokinetics / Q000652:urine; D008274:Magnesium / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000652:urine*; D008297:Male; D008900:Mineral Waters / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D013054:Spectrophotometry, Atomic; D013431:Sulfates / Q000494:pharmacology*
chemical_list: D001639:Bicarbonates; D007554:Isotopes; D008900:Mineral Waters; D013431:Sulfates; D008274:Magnesium