Phosphorodiamides as prodrugs for antiviral nucleosides.
New phosphorodiamides of modified nucleoside monophosphates were synthesized and their antiviral properties were evaluated.
Shipitsyn
Alexander V
AV
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia. aal@imb.ac.ru
Zakirova
Natalya F
NF
Belanov
Evgeny F
EF
Pronyaeva
Tatyana R
TR
Fedyuk
Nina V
NV
Kukhanova
Marina K
MK
Pokrovsky
Andrey G
AG
D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D009711:Nucleotides / Q000737:chemistry / Q000494:pharmacology*; D017553:Phosphorus Compounds / Q000737:chemistry / Q000494:pharmacology*; D010766:Phosphorylation; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology*; D018119:Stavudine / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D015215:Zidovudine / Q000737:chemistry / Q000494:pharmacology
D019380:Anti-HIV Agents; D000998:Antiviral Agents; D009711:Nucleotides; D017553:Phosphorus Compounds; D011355:Prodrugs; D015215:Zidovudine; D018119:Stavudine; C436301:phosphorodiamidic acid