title: Improved synthesis of 2'-amino-LNA.
abstract: 2'-Amino-LNA phosphoramidite (10) was synthesised by means of a new strategy, which is convergent with the synthesis of 2'-oxy-LNA up until a late stage intermediate (1).
authors.affiliation: Cureon A/S, Copenhagen, Denmark. smc@cureon.com
authors.forename: Signe M
authors.initials: SM
authors.lastname: Christensen
authors.forename: Christoph
authors.initials: C
authors.lastname: Rosenbohm
authors.forename: Mads
authors.initials: M
authors.lastname: Sørensen
authors.forename: Lotte-Emilie
authors.initials: LE
authors.lastname: Larsen
authors.forename: Jesper
authors.initials: J
authors.lastname: Wengel
authors.forename: Troels
authors.initials: T
authors.lastname: Koch
mesh_terms: D000577:Amides; D000588:Amines; D007202:Indicators and Reagents; D008968:Molecular Conformation; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis*; D010756:Phosphoric Acids
chemical_list: D000577:Amides; D000588:Amines; D007202:Indicators and Reagents; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; D010756:Phosphoric Acids; C477371:locked nucleic acid; C011067:phosphoramidic acid