Use of sonication for the coupling of sterically hindered substrates in the phenolic Mitsunobu reaction.
A vast rate increase in the Mitsunobu reaction of phenols with alcohols where either or both are sterically hindered has been achieved by the use of high concentration combined with sonication.
Lepore
Salvatore D
SD
Department of Chemistry, Florida Atlantic University, Boca Raton, Florida 33431-0991, USA. slepore@fau.edu
He
Yuanjun
Y