Oxygenation in a human tumor xenograft: manipulation through respiratory challenge and antibody-directed infarction.
We recently demonstrated the use of 19F NMR relaxometry of hexafluorobenzene to monitor regional tumor oxygen tension dynamics in rats. We have now extended the application to human tumors implanted in immunocompromised (SCID) mice. This has allowed us both to investigate dynamic response to respiratory challenge (carbogen) and to probe the mechanisms of a new anti-vascular therapy designed to produce tumor-specific infarction.
Mason
Ralph P
RP
Department of Radiology, U.T. Southwestern Medical Center, Dallas, TX 75390, USA.
Constantinescu
Anca
A
Ran
Sophia
S
Thorpe
Philip E
PE
D000818:Animals; D005466:Fluorocarbons / Q000378:metabolism; D006689:Hodgkin Disease / Q000378:metabolism / Q000473:pathology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D014183:Transplantation, Heterologous
D005466:Fluorocarbons; C003005:hexafluorobenzene; D010100:Oxygen