Linezolid-associated toxic optic neuropathy: a report of 2 cases.
We describe 2 cases in which the prolonged use of linezolid to treat complicated methicillin-resistant Staphylococcus aureus infections was followed by acutely developed blurred vision and progressive loss of vision and color perception during the ensuing few weeks. Both patients received a diagnosis of toxic optic neuropathy, and linezolid therapy was stopped. The patients experienced an initial rapid partial improvement and a subsequent gradual, almost complete, recovery over many months.
Division of Infectious Diseases, New York University School of Medicine, New York, New York, USA.
Elsie
E
Lee
Susanne
S
Burger
Jilan
J
Shah
Christine
C
Melton
Michael
M
Mullen
Floyd
F
Warren
Robert
R
Press
D000081:Acetamides / Q000009:adverse effects* / Q000627:therapeutic use; D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D000069349:Linezolid; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000503:physiopathology; D023303:Oxazolidinones / Q000009:adverse effects* / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid