Ischaemic change of the human intestine after total portal occlusion during liver resection.
This is a clinical study of the use of several monitoring techniques to evaluate the effect of total hepatic inflow occlusion on intestinal ischaemia during liver resection. A total of 8 patients was studied. Parameters measured included intestinal oxygen extraction ratio, portal venous and arterial lactate levels and intestinal intramucosal pH (pHi), measured by an intraluminal tonometer. When venous outflow of the intestine was occluded, intestinal oxygen extraction ratio increased and portal venous lactate increased significantly, but arterial lactate did not increase significantly until after 60 minutes of occlusion. Intestinal pHi decreased significantly after 60 minutes. Following release of the occlusion, oxygen extraction and pHi returned to normal in 7 out of 8 patients. The 1 patient who had a persistent decrease in pHi died postoperatively. These findings indicate that a marked drop in pHi after total portal occlusion and persistent low pHi following the release of a portal occlusion are associated with the development of complications and mortality during liver resection.
Departments of Surgery and Anaesthesiology, Veterans General Hospital-Taipei, National Yang-Ming University, Taiwan, Republic of China.
K L
KL
King
G J
GJ
Tang
C W
CW
Wu
W Y
WY
Lui
D000328:Adult; D000368:Aged; D005260:Female; D042882:Gallstones / Q000601:surgery; D006498:Hepatectomy; D006801:Humans; D007422:Intestines / Q000098:blood supply*; D019344:Lactic Acid / Q000097:blood; D008113:Liver Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D011184:Postoperative Period; D012039:Regional Blood Flow
D019344:Lactic Acid