Prefrontal neuronal activity encodes spatial target representations sequentially updated after nonspatial target-shift cues.
We examined prefrontal neuronal activity while monkeys performed a sequential target-shift task, in which, after a positional cue indicated the initial saccade target among 8 peripheral positions, the monkeys were required to internally shift the target by one position on every flash of a target-shift cue. The target-shift cue appeared in the center 0 to 3 times within a single trial and was always the same in shape, size, and color. We found selective neuronal activity related to the target position: when the target-shift cue implied the target shift to particular peripheral positions, neurons exhibited early-dominant and late-dominant activity during the following delay period. The early-dominant target-selective activity emerged early in the delay just after the presentation of the target-shift cue, whereas the late-dominant activity gradually built up toward the end of the delay. Because the target-shift cue was not related to any specific target location, the early-dominant target-selective activity could not be a mere visual response to the target-shift cue. We suggest that the early-dominant activity reflects the transitory representation for the saccade target that was triggered by the nonspatial target-shift cue, whereas the late-dominant activity reflects the target representation in the spatial working memory or the preparatory set for the possible impending saccade, being repeatedly updated during sequential target shifts.
Fukushima
Tetsuya
T
Department of Physiology, The University of Tokyo School of Medicine, Tokyo 113-0033, Japan.
Hasegawa
Isao
I
Miyashita
Yasushi
Y
D000818:Animals; D003463:Cues; D016208:Databases, Factual; D004567:Electrodes, Implanted; D007839:Functional Laterality / Q000502:physiology; D008251:Macaca; D008570:Memory, Short-Term / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D011153:Population; D017397:Prefrontal Cortex / Q000166:cytology / Q000502:physiology*; D011597:Psychomotor Performance; D012044:Regression Analysis; D012438:Saccades / Q000502:physiology; D013028:Space Perception / Q000502:physiology*