[The treatment of keloids].
Keloids are benign fibrous growths with characteristic clinical features, whose underlying pathogenic mechanisms are not fully understood. While numerous treatment approaches are available, there is little evidence for efficacy based on controlled clinical studies. Therapeutic results are often not satisfactory. The best approach employs multiple modalities appropriate for the stage of the lesion. Combining invasive methods such as cryotherapy, surgery, intralesional steroid injections, laser or radiotherapy with external or physical approaches has helped to optimize treatment efficacy. Newer clinical studies with intralesional substances such as interferons which may directly influence collagen metabolism show promising results; these substances may be valuable therapeutic additions.
Klinik und Poliklinik für Dermatologie, Universitätsklinikum Carl Gustav Carus Dresden an der Technische Universität Dresden. Ingrid.Hackert@mailbox.tu-dresden.de
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D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000367:Age Factors; D001458:Bandages; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003452:Cryosurgery; D017679:Cryotherapy; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D007627:Keloid / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D053685:Laser Therapy; D008297:Male; D011182:Postoperative Care; D011183:Postoperative Complications; D011247:Pregnancy; D012008:Recurrence; D012867:Skin / Q000473:pathology; D016038:Skin Transplantation; D013997:Time Factors
D000305:Adrenal Cortex Hormones