[Poorly differentiated breast carcinoma with an abundant myoepithelial component: morphologic and immunohistochemical features and mammaglobin gene expression ].
In this report, we describe a case of poorly differentiate myoepithelial cell rich carcinoma in with morphological findings of large poligonal nests with festoon-like pattern sometimes showing central necrosis, reminiscent of a comedo-like pattern and numerous mitoses. Immunohistochemical staining shows positive reaction for cytokeratin AE/1, CAM 5.2, 34 beta E12, vimentin, smooth muscle actin, EMA, S100 protein and oncogene cERB.b2 and negative for estrogen, progesterone, GFAP and chromogranin. Moreover, this carcinoma show the expression of the mammaglobin mRNA, a highly specific marker of breast epithelial cells that it is not expressed in all breast carcinoma.
Bonadio
A G
AG
Servizio di Anatomia e Istologia Patologica, Ospedale S. Andrea, via Mario Asso 2, 19124 La Spezia. anatomia@ausl5.la-spezia.it
Ferro
P
P
Moroni
M
M
Gorji
N
N
Giannico
A
A
Dessanti
P
P
Fais
F
F
Bacigalupo
B
B
Roncella
S
S
Fedeli
F
F
D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D002277:Carcinoma / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D004847:Epithelial Cells / Q000737:chemistry; D005260:Female; D006801:Humans; D060785:Mammaglobin A; D009208:Myoepithelioma / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D009363:Neoplasm Proteins / Q000032:analysis / Q000235:genetics*; D009928:Organ Specificity; D012333:RNA, Messenger / Q000032:analysis*; D012334:RNA, Neoplasm / Q000032:analysis*; D014598:Uteroglobin / Q000235:genetics*
D014408:Biomarkers, Tumor; D060785:Mammaglobin A; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D012334:RNA, Neoplasm; C556448:SCGB2A2 protein, human; D014598:Uteroglobin