11,12-epoxyeicosatrienoic acid (11,12-EET): structural determinants for inhibition of TNF-alpha-induced VCAM-1 expression.
A series of 11,12-EET analogues were synthesized and compared using a human endothelial cell based TNF-alpha-induced VCAM-1 expression assay. The resulting data were used to map a putative recognition/binding domain for 11,12-EET.
Falck
J R
JR
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9038, USA. j.falck@utsouthwestern.edu
Reddy
L Manmohan
LM
Reddy
Y Krishna
YK
Bondlela
Muralidhar
M
Krishna
U Murali
UM
Ji
Yu
Y
Sun
Jianxin
J
Liao
James K
JK
D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D001665:Binding Sites; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D006801:Humans; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D019010:Vascular Cell Adhesion Molecule-1 / Q000737:chemistry / Q000187:drug effects / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1; C046783:11,12-epoxy-5,8,14-eicosatrienoic acid; D015126:8,11,14-Eicosatrienoic Acid