Adenine-copper coordination polymer as an oxidative nucleozyme: implications for simple prebiotic catalytic units.
Plasmid modification activity of a modified adenine-copper coordination polymer, in the presence of peracids and thiols, and ensuing preliminary mechanistic investigations are reported. These observations, when coupled with unique coordination pattern of the metal complex, have led us to propose that a synergistic interaction between nucleobases and metal ions may be responsible for primordial catalysis of certain key reactions of biochemical significance and could serve the function of a prototypical, prebiotic nucleozyme.
Srivatsan
S G
SG
Department of Chemistry, Indian Institute of Technology-Kanpur, Kanpur, 208016 (UP), India.
Parvez
Masood
M
Verma
Sandeep
S
D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D000227:Adenine Nucleotides / Q000378:metabolism; D001704:Biopolymers / Q000737:chemistry / Q000378:metabolism; D002384:Catalysis; D003300:Copper / Q000737:chemistry* / Q000378:metabolism; D004278:DNA, Superhelical / Q000737:chemistry; D008958:Models, Molecular; D010084:Oxidation-Reduction; D010795:Phthalic Acids / Q000494:pharmacology; D010957:Plasmids / Q000737:chemistry / Q000378:metabolism; D016337:RNA, Catalytic / Q000737:chemistry* / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000494:pharmacology; D013464:Sulfuric Acids / Q000494:pharmacology
D000227:Adenine Nucleotides; D001704:Biopolymers; D004278:DNA, Superhelical; D010795:Phthalic Acids; D016337:RNA, Catalytic; D013438:Sulfhydryl Compounds; D013464:Sulfuric Acids; D003300:Copper; C048813:potassium peroxymonosulfuric acid; D000225:Adenine; C044731:magnesium monoperoxyphthalate