Oscillations, resonances and noise: basis of flexible neuronal pattern generation.
Modulation of neuronal impulse pattern is examined by means of a simplified Hodgkin-Huxley type computer model which refers to experimental recordings of cold receptor discharges. This model essentially consists of two potentially oscillating subsystems: a spike generator and a subthreshold oscillator. With addition of noise the model successfully mimics the major types of experimentally recorded impulse patterns and thereby elucidate different resonance behaviors. (1) There is a range of rhythmic spiking or bursting where the spike generator is strongly coupled to the subthreshold oscillator. (2) There is a pacemaker activity of more complex interactions where the spike generator has overtaken part of the control. (3) There is a situation where the two subsystems are decoupled and only resonate with the help of noise.
Braun
Hans A
HA
Laboratory of Neurodynamics, Institute of Physiology, University of Marburg, Deutschhausstr. 2, D-35037 Marburg, Germany. braun@mailer.uni-marburg.de
Voigt
Karlheinz
K
Huber
Martin T
MT
D000818:Animals; D003080:Cold Temperature; D003198:Computer Simulation; D004594:Electrophysiology; D006801:Humans; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D009991:Oscillometry; D013823:Thermoreceptors / Q000502:physiology