Genome-wide scan for linkage in finnish hereditary prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26.
BACKGROUND
In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome-wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families.


METHODS
Altogether 87 DNA samples were genotyped from 13 families. Logarithm-of-odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown.


RESULTS
The highest LOD scores in the affected-only analyses were found at 11q14, where the two-point LOD score was 2.97 (theta = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non-parametric-linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25-26, with a two-point LOD score of 2.57 (theta = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02).


CONCLUSIONS
The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.
Schleutker
Johanna
J
Laboratory of Cancer Genetics, University of Tampere and Tampere University Hospital, Tampere, Finland. Johanna.schleutker@uta.fi
Baffoe-Bonnie
Agnes B
AB
Gillanders
Elizabeth
E
Kainu
Tommi
T
Jones
Mary-Pat
MP
Freas-Lutz
Diana
D
Markey
Carol
C
Gildea
Derek
D
Riedesel
Erica
E
Albertus
Julie
J
Gibbs
Kenneth D
KD
Matikainen
Mika
M
Koivisto
Pasi A
PA
Tammela
Teuvo
T
Bailey-Wilson
Joan E
JE
Trent
Jeffrey M
JM
Kallioniemi
Olli-P
OP
D000368:Aged; D000369:Aged, 80 and over; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D004273:DNA, Neoplasm / Q000737:chemistry / Q000235:genetics; D005190:Family; D005260:Female; D005387:Finland; D008040:Genetic Linkage / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011471:Prostatic Neoplasms / Q000235:genetics*; D017422:Sequence Analysis, DNA; D018709:Statistics, Nonparametric; D013274:Stomach Neoplasms / Q000235:genetics
D004273:DNA, Neoplasm