[Preliminary study on gene expression profile of endometrial adenocarcinoma].
OBJECTIVE
To determine candidate genes of endometrial adenocarcinoma.


METHODS
To compare the gene expression profile in 2 endometrial adenocarcinoma tissues and 2 normal endometria by HGEC-40s GeneChip probe including 4096 genes array. Expression differences between normal and malignant tissue groups were measured by GenePixPro3.0 software.


RESULTS
350 genes with a ratio below 0.5 and above 2.0 showed discrimination between normal and malignant groups. Thirty three genes with ratio above 3 were up-regulated, forty-four genes with ratio below 0.3 were down-regulated.


CONCLUSIONS
The overexpression of oncogenes with their disturbed or constitutively activated signal transduction cascades alone or in combination with the mutation-induced silencing of tumor suppressor genes is associated with malignant transformation.
Department of Gynecology, Women's Hospital, Medical Collage, Zhejiang University, Hangzhou 310006, China.
Huai-jun
HJ
Zhou
Yi-fu
YF
Shi
Juan-qing
JQ
Li
Jin-quan
JQ
Cui
D000230:Adenocarcinoma / Q000235:genetics*; D064127:Aurora Kinases; D018797:Cell Cycle Proteins; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D058851:GPI-Linked Proteins; D020869:Gene Expression Profiling; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics
D018797:Cell Cycle Proteins; C096192:GAS1 protein, human; D058851:GPI-Linked Proteins; D008565:Membrane Proteins; D019009:Proto-Oncogene Proteins c-kit; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases