Stem cell mobilization by G-CSF in solid and hematological malignancies: single daily dose is better than split dose in obese patients.
In the past, variable results were reported for single daily and two divided daily doses of granulocyte colony-stimulating factor (G-CSF) in stem cell collection where no study exists investigating the effect of body mass index (BMI) on mobilization. The numbers of CD34(+) cells collected were compared in 86 patients with solid or hematological malignancies receiving either single daily (14 mug/kg/day) G-CSF (filgrastim) as group I (n=36) or two divided doses of G-CSF daily (2 x 7 mug/kg/day) as group II (n = 50). Both groups were divided into subgroups according to their BMI as group a (BMI </=25 kg/m(2)) and group b (BMI >25 kg/m(2)). Two groups were similar in terms of BMI, gender, and disease characteristics. All patients have received G-CSF as a single or two divided doses subcutaneously and aphereses have been done on the 5th day. No significant difference in numbers of CD34(+) cells between groups Ia and Ib, groups IIa and IIb, and groups Ia and IIa was found. On the other hand, the mean ratio and the number of CD34(+) cells in group Ib were significantly higher than those of group IIb (0.58 +/- 0.06% vs. 0.37 +/- 0.26%, P = 0.01 and 3.67 +/- 0.65 x 10(4)/kg/ml vs. 1.92 +/- 0.37 x 10(4)/kg/ml, P= 0.02). In conclusion, in patients with BMI >25 kg/m(2), once daily G-CSF compared to split dose administration induces a greater number of CD34(+) stem cell mobilization, which suggests the presence of a different pharmacokinetics in obese patients.
Department of Hematology, Gülhane Military Medical Academy, Ankara, Turkey. aturkercetin@yahoo.com
Türker
T
Cetin
Fikret
F
Arpaci
Ahmet
A
Ozet
Bekir
B
Oztürk
Seref
S
Kömürcü
Ali
A
Ihsan Uzar
Ilker
I
Yilmaz
Murat
M
Beyzadeoĝlu
Kaan
K
Oysul
Selmin
S
Ataergin
Okan
O
Kuzhan
Aysel
A
Pekel
D000293:Adolescent; D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000096:biosynthesis; D001781:Blood Component Removal / Q000379:methods; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D019337:Hematologic Neoplasms / Q000628:therapy*; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000378:metabolism*; D009765:Obesity / Q000150:complications*
D018952:Antigens, CD34; D016179:Granulocyte Colony-Stimulating Factor