Tissue factor-activated thromboelastograms in children undergoing cardiac surgery: baseline values and comparisons.
Activation of clotting with tissue factor (TF) allows rapid evaluation of thromboelastograms but alters the values of thromboelastogram variables. We have performed TF-activated thromboelastograms in 250 children <2 yr old undergoing cardiac surgery to establish baseline values. Five groups were distinguished to evaluate the effects of quantitative deficiencies in coagulation factor levels during infancy: <30 days, 1-3 mo, 3-6 mo, 6-12 mo, and 12-24 mo. Activation of clotting (R and K values) was similar among groups. Infants 1-3 mo of age demonstrated increased clot strength compared with the other groups, a finding similar to previous evaluation of native thromboelastograms. The alpha and maximum amplitude values were numerically almost identical in each age group, a unique finding in activated thromboelastograms. Fibrinolysis was similar among groups. We believe that knowledge of baseline TF-activated thromboelastogram variables in young children will be useful in interpreting these thromboelastograms in clinical scenarios, in using these thromboelastograms as part of coagulopathy treatment algorithms, and during the application of more specific thromboelastogram modifiers. Additionally, the similarity of alpha and maximum amplitude values in each age group will allow even faster interpretation of thromboelastogram data.


CONCLUSIONS
Baseline values for tissue factor-activated thromboelastograms in young children undergoing cardiac surgery have been established and will permit accurate use and interpretation of this thromboelastogram modification in evaluating and managing coagulopathies.
Miller
Bruce E
BE
Department of Anesthesiology, Emory University School of Medicine, Children's Healthcare of Atlanta at Egleston, Atlanta, Georgia.
Guzzetta
Nina A
NA
Tosone
Steven R
SR
Miller
Jennifer L
JL
Flunker
Annabel R
AR
Silvey
Eva M
EM
Levy
Jerrold H
JH
D000465:Algorithms; D001777:Blood Coagulation; D006348:Cardiac Surgical Procedures; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery; D006490:Hemostatics; D019763:Heparin Lyase; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors; D013916:Thrombelastography; D013925:Thromboplastin
D006490:Hemostatics; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D013925:Thromboplastin; D019763:Heparin Lyase