[The effect of repeated sevoflurane anesthesia on hepatic function and immunological system].
BACKGROUND
Sevoflurane is known as a useful and safe anesthetic because of its properties of fast uptake and elimination at the lungs and of no effects on hepatic function. In this study we examined the effect of repeated sevoflurane anesthesia on hepatic function and immunological system.


METHODS
Eight patients (ASA, PS 2 or 3) received sevoflurane anesthesia three times in 6 months. Six patients had emergency operation for injuries. Aspirate transaminase (AST), alanine transaminase (ALT) and complements (CH50, C3, C4) were measured prior to anesthesia, and 1, 7 and 14 days after anesthesia.


RESULTS
The values of AST and ALT were high prior to anesthesia at the first anesthesia. However, these were of no significant changes. CH50, C3, C4 increased significantly after the first anesthesia. However, there were no significant changes of these complements after the second and the third anesthesia.


CONCLUSIONS
Our results suggest that sevoflurane is not likely to provide adverse effects on the liver and to suppress the production of complements accompanied by the surgical stress.
Department of Anesthesiology, St. Marianna University, Yokohama City Seibu Hospital, Yokohama 241-0811.
Eri
E
Sato
Kazuko
K
Nagano
Noriko
N
Akasaka
Satoshi
S
Manaka
Takeshi
T
Tateda
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000768:Anesthesia, General; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D015941:Complement Hemolytic Activity Assay; D005260:Female; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008111:Liver Function Tests; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects*; D008875:Middle Aged; D000077149:Sevoflurane; D013997:Time Factors
D018685:Anesthetics, Inhalation; D015415:Biomarkers; D003176:Complement C3; D003181:Complement C4; D008738:Methyl Ethers; D000077149:Sevoflurane; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase