Norfloxacin-induced electroencephalogram alteration and seizures in rats are not triggered by enhanced levels of intracerebral glutamate.
Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram (EEG) effect was combined with intracerebral glutamate determinations using microdialysis for rats receiving norfloxacin intravenously (150 mg/kg of body weight). The EEG effect (accompanied by tremors and seizures) was consistently observed without glutamate level modifications. Therefore, norfloxacin-inducted seizures are not triggered by intracerebral glutamate level enhancement.
Equipe Médicaments anti-infectieux et barrière hémato-encéphalique, PBS, Faculté de Médecine & Pharmacie, and Laboratoire de Pharmacocinétique, PBS, CHU La Milétrie, 86022 Poitiers Cedex, France.
Marylore
M
Chenel
Anne
A
Limosin
Sandrine
S
Marchand
Joël
J
Paquereau
Olivier
O
Mimoz
William
W
Couet
D000818:Animals; D000890:Anti-Infective Agents / Q000493:pharmacokinetics / Q000633:toxicity*; D019540:Area Under Curve; D001923:Brain Chemistry / Q000187:drug effects*; D004569:Electroencephalography / Q000187:drug effects*; D018698:Glutamic Acid / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D017551:Microdialysis; D009643:Norfloxacin / Q000493:pharmacokinetics / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced*
D000890:Anti-Infective Agents; D018698:Glutamic Acid; D009643:Norfloxacin