A genome-wide German screen for linkage disequilibrium in multiple sclerosis.
We report on a genome-wide screen for association with multiple sclerosis (MS) in the German population performed using 6000 microsatellite markers. These markers were typed in four DNA pools consisting of 234 MS patients (cases), 209 unrelated controls, 68 index patients from trio families and their 136 parents (related controls). Stringent analysis identified 11 markers showing apparent evidence for association. Five from regions previously identified in linkage studies and two from the MHC region on chromosome 6p21. These MHC markers are known to be in linkage disequilibrium with HLA class II alleles influencing susceptibility to MS. The identification of these markers serves as an important positive control.
Weber
Alexandra
A
Neuroscience Research Center, Institute of Neuroimmunology, Charitè University Hospital, 10098 Berlin, Germany.
Infante-Duarte
Carmen
C
Sawcer
Stephen
S
Setakis
Efrosini
E
Bellmann-Strobl
Judith
J
Hensiek
Anke
A
Rueckert
Sandra
S
Schoenemann
Constanze
C
Benediktsson
Kjartan
K
Compston
Alastair
A
Zipp
Frauke
F
D000328:Adult; D000483:Alleles; D005260:Female; D005787:Gene Frequency; D005820:Genetic Testing / Q000379:methods*; D015894:Genome, Human; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007391:International Cooperation; D015810:Linkage Disequilibrium; D008297:Male; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*