Development of HSV-mediated gene transfer for the treatment of chronic pain.
Chronic pain is often difficult to treat effectively. We have exploited the high affinity of herpes simplex virus (HSV) for peripheral sensory neurons to create HSV-based vectors for the treatment of chronic pain. We have demonstrated that an HSV-based vector expressing proenkephalin reduces pain-related responses in rodent models of inflammatory pain, neuropathic pain, and pain resulting from cancer in bone. A human trial has been proposed.
Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Marina
M
Mata
Joseph
J
Glorioso
David J
DJ
Fink
D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004745:Enkephalins / Q000378:metabolism; D005727:Ganglia, Spinal / Q000166:cytology / Q000378:metabolism / Q000821:virology; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D005822:Genetic Vectors; D006801:Humans; D008026:Ligation / Q000379:methods; D010146:Pain / Q000662:veterinary / Q000821:virology; D059408:Pain Management; D010147:Pain Measurement; D017288:Pain Threshold; D011498:Protein Precursors / Q000378:metabolism; D051381:Rats; D018139:Simplexvirus / Q000235:genetics*; D013997:Time Factors
D004745:Enkephalins; D011498:Protein Precursors; C029992:proenkephalin