Pharmacologic treatment of polycystic ovary syndrome.
Women with polycystic ovary syndrome (PCOS) most often seek treatment for reduction of hair growth and/or acne, restoration of menstrual cyclicity, and infertility. In addition, these patients are increasingly seeking advise and treatment for the metabolic abnormalities related to PCOS (e.g., insulin resistance and type 2 diabetes). In this review, we outline the pathophysiologic events underlying the cutaneous manifestations of androgen excess and provide a rationale for use of the various pharmacologic agents available for treatment. Options for the treatment of the reproductive abnormalities (menstrual dysfunction and interfility) are presented. Finally, the metabolic manifestations of PCOS are reviewed and their treatment is discussed.
Ehrmann
David A
DA
Department of Medicine, Section of Endocrinology, The University of Chicago, Chicago, Illinois 60637, USA.
Rychlik
Daniel
D
D000152:Acne Vulgaris / Q000188:drug therapy / Q000209:etiology; D000568:Amenorrhea / Q000188:drug therapy / Q000209:etiology; D005260:Female; D018149:Glucose Intolerance / Q000188:drug therapy; D006628:Hirsutism / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy / Q000209:etiology; D007333:Insulin Resistance; D009839:Oligomenorrhea / Q000188:drug therapy / Q000209:etiology; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy*