No association between the sigma receptor type 1 gene and schizophrenia: results of analysis and meta-analysis of case-control studies.
BACKGROUND
Several lines of evidence have supported possible roles of the sigma receptors in the etiology of schizophrenia and mechanisms of antipsychotic efficacy. An association study provided genetic evidence that the sigma receptor type 1 gene (SIGMAR1) was a possible susceptibility factor for schizophrenia, however, it was not replicated by a subsequent study. It is necessary to evaluate further the possibility that the SIGMAR1 gene is associated with susceptibility to schizophrenia.


METHODS
A case-control association study between two polymorphisms of the SIGMAR1 gene, G-241T/C-240T and Gln2Pro, and schizophrenia in Japanese population, and meta-analysis including present and previous studies.


RESULTS
There was no significant association of any allele or genotype of the polymorphisms with schizophrenia. Neither significant association was observed with hebephrenic or paranoid subtype of schizophrenia. Furthermore, a meta-analysis including the present and previous studies comprising 779 controls and 636 schizophrenics also revealed no significant association between the SIGMAR1 gene and schizophrenia.


CONCLUSIONS
In view of this evidence, it is likely that the SIGMAR1 gene does not confer susceptibility to schizophrenia.
Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Shikata-cho 2-5-1, Okayama, 700-8558, Japan. utties@mac.com
Naohiko
N
Uchida
Hiroshi
H
Ujike
Kenji
K
Nakata
Manabu
M
Takaki
Akira
A
Nomura
Takeshi
T
Katsu
Yuji
Y
Tanaka
Takaki
T
Imamura
Ayumu
A
Sakai
Shigetoshi
S
Kuroda
D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics; D017480:Receptors, sigma / Q000235:genetics*; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D012562:Schizophrenia, Disorganized / Q000208:ethnology / Q000235:genetics; D012563:Schizophrenia, Paranoid / Q000208:ethnology / Q000235:genetics; D000097605:Sigma-1 Receptor
D017480:Receptors, sigma; D000097605:Sigma-1 Receptor