The anti-HBsAg (human type B hepatitis, surface antigen) and anti-HBeAg (human type B hepatitis, e antigen) C18 dibenzocyclooctadiene lignans from Kadsura matsudai and Schizandra arisanensis.
The C(18) dibenzocyclooctadiene lignans including three novel schizanrin F (1), G (2), H (3), along with the known kadsurarin (4), were isolated from Kadsura matsudai. A new C(19) homolignan named schiarisanrin E (5), together with the known C(18) lignans, gomisin B (6), G (7) and (+)-gomisin K(3) (8) were obtained from Schizandra arisanensis. Gomisin B, G and (+)-gomisin K(3) showed moderate to strong activity for antihepatitis in anti-HBsAg (human type B hepatitis, surface antigen) and/or anti-HBeAg (human type B hepatitis, e antigen) tests. The structural elucidations of new compounds 1-3 and 5 were based on two-dimensional (2D) NMR techniques including COSY, HMQC, HMBC, NOESY and CD spectra. Preliminary structure-activity relationship studies for these isolated lignans are also discussed.
Wu
Ming-Der
MD
Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan.
Huang
Ray-Ling
RL
Kuo
Li-Ming Yang
LM
Hung
Chia-Cheng
CC
Ong
Chi-Wi
CW
Kuo
Yao-Haur
YH
D001219:Aspartate Aminotransferases / Q000378:metabolism; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D034242:Cyclooctanes / Q000737:chemistry / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D006514:Hepatitis B Surface Antigens / Q000187:drug effects*; D006513:Hepatitis B e Antigens / Q000187:drug effects*; D006801:Humans; D032135:Kadsura / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D018547:Plant Stems / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
D034242:Cyclooctanes; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D017705:Lignans; D001219:Aspartate Aminotransferases