[Early proteomics in ovarian cancer: myth or reality?].
Literature data summarizing new approaches and importance of early ovary cancer diagnostics have been reviewed. Alpha-feta-protein (AFP) and SA125 were the most reliable markers for determination of early ovary cancer stages. Nevertheless, these markers don't reflect the disease stage, malignance and they don't possess sufficient specificity. New methodical approaches have recently been introduced. They include combination of 2-D electrophoresis with mass-spectrometry. These methods allow to inventory and identify almost all proteins of various tissues. Using these methods for scanning proteins from biopsies of ovary cancer tissues new markers have been discovered.
Makarov
O V
OV
Russian State Medical University, Moscow.
Govorun
V M
VM
Taranets
I N
IN
Goufman
E I
EI
Gritsaĭ
A N
AN
Archakov
A I
AI
D014408:Biomarkers, Tumor / Q000032:analysis*; D018394:CA-125 Antigen / Q000032:analysis; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D006801:Humans; D013058:Mass Spectrometry; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*; D000509:alpha-Fetoproteins / Q000032:analysis
D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D000509:alpha-Fetoproteins