Stereochemical elucidation of the 1,4 polyketide amphidinoketide I.
The relative and absolute stereochemistry of amphidinoketide I has been determined by the total synthesis of all the diastereoisomers. Molecular modelling suggests that the natural product is not the thermodynamically preferred diastereoisomer.
Unilever Centre for Molecular Informatics, Department of Chemistry, Lensfield Road, Cambridge, UK CB2 1EW.
Louise M
LM
Walsh
Jonathan M
JM
Goodman
D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
D018942:Macrolides