Structure-function analysis and the molecular origins of anti-DNA antibodies in systemic lupus erythematosus.
Patients with the autoimmune rheumatic disease systemic lupus erythematosus (SLE or 'lupus') develop a wide variety of clinical and serological manifestations including the presence of antibodies to double-stranded DNA (dsDNA), which are often diagnostic and potentially pathogenic. In this review, we have examined the links between the structure and function of anti-dsDNA antibodies, emphasising their clinical associations. We have also reviewed studies involving animal models, the analysis of human antibody sequences and studies of, and using, computer modelling and crystal structure.
Centre for Rheumatology/Bloomsbury Rheumatology Unit, Department of Medicine, University College London, Arthur Stanley House, 50 Tottenham Street, London W1P 9PG, UK.
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J
Kalsi
C T
CT
Ravirajan
A
A
Rahman
D A
DA
Isenberg