Altered cardiovascular responses to nitrosorbide in alcohol withdrawal.
The cardiovascular effects and pharmacokinetics of a single dose (20 mg sublingually) of isosorbide dinitrate (ISDN) were studied in 9 alcohol-dependent men during alcohol withdrawal syndrome (AW) on day 1 and after the resolution of AW on day 10. At the onset of AW, ISDN and its metabolites caused a hypotensive effect, which was increased on day 10, while no differences in ISDN-induced decrease in stroke volume were observed. Tachycardiac response to ISDN was more pronounced at onset of AW. On day 10, the AUC(0-1.5 h), C(max) and t((1/2)) of ISDN were increased compared with day 1. The results of this study suggest that nitric oxide may modulate the cardiovascular system in AW.
BioMag Laboratory, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland. Seppo.Kahkonen@helsinki.fi
Seppo
S
Kähkönen
Edwin E
EE
Zvartau
D000328:Adult; D019540:Area Under Curve; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects*; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D007548:Isosorbide Dinitrate / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D013375:Substance Withdrawal Syndrome / Q000378:metabolism / Q000503:physiopathology*; D014665:Vasodilator Agents / Q000493:pharmacokinetics / Q000494:pharmacology*
D014665:Vasodilator Agents; D000431:Ethanol; D007548:Isosorbide Dinitrate