BRCA1 c.2845insA is a recurring mutation with a founder effect in Singapore Malay women with early onset breast/ovarian cancer.
Sng
J-H
JH
Department of Surgery, Faculty of Medicine, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260. sursngjh@nus.edu.sg
Ali
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Lee
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SC
Zahar
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Wong
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JE
Blake
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Sharif
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Cross
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Iau
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PT
D000328:Adult; D017668:Age of Onset; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics*; D005260:Female; D018703:Founder Effect; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease; D018095:Germ-Line Mutation; D006801:Humans; D007438:Introns; D008296:Malaysia / Q000208:ethnology; D008875:Middle Aged; D009154:Mutation; D020125:Mutation, Missense; D010051:Ovarian Neoplasms / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012846:Singapore / Q000453:epidemiology