Role of heterogeneity in deterministic models of drug dissolution and their statistical characteristics.
Dissolution of drugs is one of the crucial factors determining their global action in a body, and thus for any new solid dosage form its dissolution characteristics have to be established. A variety of empirical and semi-empirical models for drug dissolution is reviewed in this article. Their properties are investigated, the parameters are discussed and the role of drug heterogeneity is studied.
Lánský
Petr
P
Institute of Physiology, Academy of Sciences of the Czech Republic, Vídenská 1082, 142 20 Prague 4, Czech Republic. lansky@biomed.cas.cz
Weiss
Michael
M
D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D010599:Pharmacokinetics
D004364:Pharmaceutical Preparations