Deterministic hypotheses on the origin of life and of its reproduction.
The current theory of the origin of life by random polymerisation and selection of nucleic acids is challenged by the hypothesis that the primitive enzymatic sites would have been formed by abiotic polymerisation of aminoacids, specifically gathered (by saline, hydrogen, or hydrophobic interactions), around the different substrates. The information contained in these proteinoids would have been transferred to messenger-like RNAs by a mechanism reverse of that of the present protein synthesis, and then to DNA. The interactions between aminoacids and nucleotidic sequences would have been at the origin of the genetic code, as hypothesized by several authors. We propose that the specificity of the bindings would have been enhanced and 'frozen' by ternary associations with specific proteinoids (future aminoacyl tRNA synthetases). The role of chance would have been limited to the supply of the products and to the determination of the conditions of reaction. Thermodynamic considerations (dissipation of the free enthalpy through enzymatic activities) may explain the emergence of the biological systems.
Berger
G
G
14 Impasse des Carpeaux, Perigny Sur Yerres, France.
D001665:Binding Sites; D004247:DNA / Q000737:chemistry; D005815:Genetic Code; D008962:Models, Theoretical; D009696:Nucleic Acids / Q000737:chemistry*; D000069497:Origin of Life; D012333:RNA, Messenger / Q000737:chemistry; D012098:Reproduction; D013816:Thermodynamics
D009696:Nucleic Acids; D012333:RNA, Messenger; D004247:DNA