A genome screen for linkage disequilibrium in Turkish multiple sclerosis.
In order to screen the Turkish population for evidence of association with multiple sclerosis, we typed 6000 microsatellite markers in separately pooled DNA samples from 197 cases and 199 controls following the Genetic Analysis of Multiple sclerosis in EuropeanS (GAMES) protocol. Twelve markers showing evidence for association were identified. One of these markers lying directly in a region which is also implicated in the Turkish linkage screen (chromosome 5p15) and thus shows evidence for both linkage and association in independent data sets.
Department of Neurology, Istanbul Faculty of Medicine, University of Istanbul, Capa, Istanbul TR-34390, Turkey. meraksoy@turk.net
M
M
Eraksoy
A
A
Hensiek
M
M
Kurtuncu
G
G
Akman-Demir
M
M
Kilinc
M
M
Gedizlioglu
B
B
Petek-Balci
O
O
Anlar
C
C
Kutlu
G
G
Saruhan-Direskeneli
H A
HA
Idrisoglu
E
E
Setakis
A
A
Compston
S
S
Sawcer
D000328:Adult; D016022:Case-Control Studies; D004247:DNA / Q000097:blood; D005260:Female; D005820:Genetic Testing / Q000379:methods* / Q000706:statistics & numerical data; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D007391:International Cooperation; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D014421:Turkey / Q000453:epidemiology
D004247:DNA