Heterocyclic ketones as inhibitors of histone deacetylase.
Several heterocyclic ketones were investigated as potential inhibitors of histone deacetylase. Nanomolar inhibitors such as 22 and 25 were obtained, the anti-proliferative activity of which were shown to be mediated by HDAC inhibition.
Vasudevan
Anil
A
Medicinal Chemistry Technologies, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. anil.vasudevan@abbott.com
Ji
Zhiqin
Z
Frey
Robin R
RR
Wada
Carol K
CK
Steinman
Douglas
D
Heyman
H Robin
HR
Guo
Yan
Y
Curtin
Michael L
ML
Guo
Jun
J
Li
Junling
J
Pease
Lori
L
Glaser
Keith B
KB
Marcotte
Patrick A
PA
Bouska
Jennifer J
JJ
Davidsen
Steven K
SK
Michaelides
Michael R
MR
D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000494:pharmacology*; D056572:Histone Deacetylase Inhibitors; D007659:Ketones / Q000737:chemistry / Q000494:pharmacology*; D007700:Kinetics; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D006571:Heterocyclic Compounds; D056572:Histone Deacetylase Inhibitors; D007659:Ketones