Buccal delivery systems.
The oral cavity is an attractive site for drug delivery due to ease of administration and avoidance of possible drug degradation in gastrointestinal tract and first-pass metabolism. Buccal drug delivery specifically refers to the delivery of drugs within/ through buccal mucosa to affect local/systemic pharmacological actions. This review briefly describes advantages and limitations of buccal drug delivery, anatomical structure of oral mucosa, and methodology in evaluating buccal drug delivery system, focusing on physiology, pharmacology, pathology, and formulation design in line with recent developments in buccal delivery systems.
Department of Pharmacy, National University of Singapore, Singapore.
Jinsong
J
Hao
Paul W S
PW
Heng
D000269:Adhesives; D000277:Adjuvants, Pharmaceutic / Q000737:chemistry; D000278:Administration, Buccal; D000818:Animals; D001682:Biological Availability; D002463:Cell Membrane Permeability / Q000502:physiology; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D016503:Drug Delivery Systems; D009061:Mouth Mucosa / Q000033:anatomy & histology / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism*; D012469:Salivary Glands / Q000378:metabolism; D012995:Solubility
D000269:Adhesives; D000277:Adjuvants, Pharmaceutic; D004304:Dosage Forms; D004364:Pharmaceutical Preparations