Biorecognition-modulated ion fluxes through functionalized gold nanotubules as a novel label-free biosensing approach.
A novel biosensing principle is presented, based on the potentiometric monitoring of an indicator ion such as Ca2+, whose zero-current flux through chemically modified nanochannels is altered by biorecognition events.
Gyurcsányi
Robert E
RE
Laboratorium für Organische Chemie, ETH Hönggerberg, HCI E 313, CH-8093 Zürich, Switzerland. robertgy@mail.bme.hu
Vigassy
Tamás
T
Pretsch
Ernö
E
D001360:Avidin / Q000737:chemistry; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D002118:Calcium / Q000032:analysis* / Q000737:chemistry; D006046:Gold / Q000737:chemistry*; D043942:Nanotubes / Q000737:chemistry*; D011199:Potentiometry; D013997:Time Factors
D001360:Avidin; D006046:Gold; D002118:Calcium