Differences in host susceptibility to disease progression in the human challenge model of Haemophilus ducreyi infection.
With human volunteers inoculated at two sites with Haemophilus ducreyi, outcomes for a subject were not independent. In a reinfection trial, 2 of 11 previous pustule formers and 6 of 10 previous resolvers resolved all sites of infection. There was no correlation between serum bactericidal or phagocytic activity and outcome in the trial. These data indicate that different hosts are differentially susceptible to disease progression versus resolution in the model.
Spinola
Stanley M
SM
Departments of Medicine, Indiana University, Indianapolis, Indiana 46202, USA. sspinola@iupui.edu
Bong
Cliffton T H
CT
Faber
Andrew L
AL
Fortney
Kate R
KR
Bennett
Stacy L
SL
Townsend
Carisa A
CA
Zwickl
Beth E
BE
Billings
Steven D
SD
Humphreys
Tricia L
TL
Bauer
Margaret E
ME
Katz
Barry P
BP
D000328:Adult; D001770:Blood Bactericidal Activity; D018450:Disease Progression; D004198:Disease Susceptibility; D005260:Female; D006192:Haemophilus Infections / Q000276:immunology*; D006191:Haemophilus ducreyi; D006801:Humans; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis; D012189:Retrospective Studies; D013492:Suppuration / Q000276:immunology