Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients.
We report the first two genome-wide screens for linkage disequilibrium between putative multiple sclerosis (MS) susceptibility genes and genetic markers performed in the genetically homogenous Scandinavian population, using 6000 microsatellite markers and DNA pools of approximately 200 MS cases and 200 controls in each screen. Usable data were achieved from the same 3331 markers in both screens. Nine markers from eight genomic regions (1p33, 3q13, 6p21, 6q14, 7p22, 9p21, 9q21 and Xq22) were identified as potentially associated with MS in both screens.
Harbo
Hanne F
HF
Institute of Immunology, Rikshospitalet University Hospital, 0027 Oslo, Norway. h.f.harbo@labmed.uio.no
Datta
Pameli
P
Oturai
Annette
A
Ryder
Lars P
LP
Sawcer
Stephen
S
Setakis
Efrosini
E
Akesson
Eva
E
Celius
Elisabeth G
EG
Modin
Helena
H
Sandberg-Wollheim
Magnhild
M
Myhr
Kjell-Morten
KM
Andersen
Oluf
O
Hillert
Jan
J
Sorensen
Per Soelberg
PS
Svejgaard
Arne
A
Compston
Alastair
A
Vartdal
Frode
F
Spurkland
Anne
A
D000483:Alleles; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods* / Q000706:statistics & numerical data; D015894:Genome, Human; D005838:Genotype; D006650:Histocompatibility Testing; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology