Biphasic constitutive laws for biological interface evolution.
A model of tissue differentiation at the bone-implant interface is proposed. The basic hypothesis of the model is that the mechanical environment determines the tissue differentiation. The stimulus chosen is related to the bone-implant micromotions. Equations governing the evolution of the interfacial tissue are proposed and combined with a finite element code to determine the evolution of the fibrous tissue around prostheses. The model is applied to the case of an idealized hip prosthesis.
Büchler
P
P
LRO, Bat. AAB, Laboratory of Orthopedic Research, EPFL, 1015 Lausanne, Switzerland. philippe.buechler@epfl.ch
Pioletti
D P
DP
Rakotomanana
L R
LR
D000465:Algorithms; D000818:Animals; D016723:Bone Remodeling; D003198:Computer Simulation; D019544:Equipment Failure Analysis / Q000379:methods*; D005269:Femur / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D005355:Fibrosis / Q000209:etiology / Q000503:physiopathology; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D007593:Joint Instability / Q000209:etiology* / Q000503:physiopathology*; D008954:Models, Biological; D009038:Motion; D011475:Prosthesis Failure; D013314:Stress, Mechanical; D013499:Surface Properties; D016896:Treatment Outcome; D016474:Weight-Bearing