An emotion-induced retrograde amnesia in humans is amygdala- and beta-adrenergic-dependent.
The influence of emotion on human memory is associated with two contradictory effects in the form of either emotion-induced enhancements or decrements in memory. In a series of experiments involving single word presentation, we show that enhanced memory for emotional words is strongly coupled to decrements in memory for items preceding the emotional stimulus, an effect that is more pronounced in women. These memory effects would appear to depend on a common neurobiological substrate, in that enhancements and decrements are reversed by propranolol, a beta-adrenergic antagonist, and abolished by selective bilateral amygdala damage. Thus, our findings suggest that amygdala-dependent beta-adrenergic modulation of episodic encoding has costs as well as benefits.
Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, United Kingdom. bstrange@fil.ion.ucl.ac.uk
B A
BA
Strange
R
R
Hurlemann
R J
RJ
Dolan
D000328:Adult; D000648:Amnesia, Retrograde / Q000209:etiology*; D000679:Amygdala / Q000378:metabolism*; D004644:Emotions; D005260:Female; D006801:Humans; D007802:Language; D008297:Male; D008568:Memory; D010919:Placebos; D011433:Propranolol / Q000494:pharmacology; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012737:Sex Factors; D013060:Speech
D010919:Placebos; D011943:Receptors, Adrenergic, beta; D011433:Propranolol