Altered cardiovascular responses to nitrosorbide in alcohol withdrawal.
The cardiovascular effects and pharmacokinetics of a single dose (20 mg sublingually) of isosorbide dinitrate (ISDN) were studied in 9 alcohol-dependent men during alcohol withdrawal syndrome (AW) on day 1 and after the resolution of AW on day 10. At the onset of AW, ISDN and its metabolites caused a hypotensive effect, which was increased on day 10, while no differences in ISDN-induced decrease in stroke volume were observed. Tachycardiac response to ISDN was more pronounced at onset of AW. On day 10, the AUC(0-1.5 h), C(max) and t((1/2)) of ISDN were increased compared with day 1. The results of this study suggest that nitric oxide may modulate the cardiovascular system in AW.
Kähkönen
Seppo
S
BioMag Laboratory, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland. Seppo.Kahkonen@helsinki.fi
Zvartau
Edwin E
EE
D000328:Adult; D019540:Area Under Curve; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects*; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D007548:Isosorbide Dinitrate / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D013375:Substance Withdrawal Syndrome / Q000378:metabolism / Q000503:physiopathology*; D014665:Vasodilator Agents / Q000493:pharmacokinetics / Q000494:pharmacology*
D014665:Vasodilator Agents; D000431:Ethanol; D007548:Isosorbide Dinitrate