Azulene incorporation and release by hydrogel containing methacrylamide propyltrimenthylammonium chloride, and its application to soft contact lens.
We have developed the epoch-making contact lens that is equipped with drug delivery system. The hydrogels contain cationic functional group in its side chain were prepared with 2-hydroxyethyl methacylate (HEMA) and methacrylamide propyltrimethylammonium chloride (MAPTAC). The obtained hydrogel is capable to store the anionic drug such as azulene based on ion-exchange reaction. The incorporated anionic drug would be released in physiological condition. The size change of the hydrogel may occur before and after drug release, but we have discovered that the addition of anionic monomer such as methacrylic acid (MAA) and 2-methacryloxyethyl acid phosphate (MOEP) to the above-mentioned composition is effective to prevent the size change, indicating that this hydrogel has the possibility to be applied as a significant drug delivery system device.
Uchida
Rei
R
Research and Development Department, SEED Co., Ltd., 117-1 Kano, Okegawa, Saitama 363-0001, Japan. rei_uchida@seed.co.jp
Sato
Takao
T
Tanigawa
Haruyasu
H
Uno
Kenji
K
D000643:Ammonium Chloride / Q000737:chemistry*; D052176:Azulenes; D001672:Biocompatible Materials / Q000737:chemistry; D003263:Contact Lenses, Hydrophilic; D003508:Cycloheptanes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D020100:Hydrogels / Q000737:chemistry*; D007474:Ion Exchange; D008689:Methacrylates / Q000737:chemistry*; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D014867:Water / Q000737:chemistry
D052176:Azulenes; D001672:Biocompatible Materials; D003508:Cycloheptanes; D003692:Delayed-Action Preparations; D020100:Hydrogels; D008689:Methacrylates; D009570:Nitriles; D000643:Ammonium Chloride; D014867:Water; C008384:methacrylic acid; C026575:2-hydroxyethyl methacrylate phosphate; C005044:hydroxyethyl methacrylate; C004919:ethylene dimethacrylate; C005525:azulene; C400723:MAPTAC; C004526:azobis(isobutyronitrile)