Power of QTL detection using association tests with family controls.
The power of testing for a population-wide association between a biallelic quantitative trait locus and a linked biallelic marker locus is predicted both empirically and deterministically for several tests. The tests were based on the analysis of variance (ANOVA) and on a number of transmission disequilibrium tests (TDT). Deterministic power predictions made use of family information, and were functions of population parameters including linkage disequilibrium, allele frequencies, and recombination rate. Deterministic power predictions were very close to the empirical power from simulations in all scenarios considered in this study. The different TDTs had very similar power, intermediate between one-way and nested ANOVAs. One-way ANOVA was the only test that was not robust against spurious disequilibrium. Our general framework for predicting power deterministically can be used to predict power in other association tests. Deterministic power calculations are a powerful tool for researchers to plan and evaluate experiments and obviate the need for elaborate simulation studies.
Roslin Institute (Edinburgh), Roslin, Midlothian EH25 9PS, Scotland, UK. jules.Hernandez@bbsrc.ac.uk
Jules
J
Hernández-Sánchez
Chris S
CS
Haley
Peter M
PM
Visscher
D000704:Analysis of Variance; D005787:Gene Frequency; D005819:Genetic Markers; D005828:Genetics, Population; D006801:Humans; D015810:Linkage Disequilibrium; D011336:Probability; D040641:Quantitative Trait Loci
D005819:Genetic Markers