[Bone metabolism in adolescent girls with short course of anorexia nervosa].
OBJECTIVE
The objective of this study was to determine the prevalence of bone mass reduction and determine its causes in young girls with short course of anorexia nervosa (AN).


METHODS
Bone mineral density (BMD)of lumber spine by dual energy x-ray absorptiometry, total alkaline phosphatase (TAP), bone-Gla protein (BGP), urine deoxypyridinoline (DPYR), DPYR, urine calcium, sex hormones were measured in 24 in-patient girls with diagnosed AN and 20 healthy volunteers.


RESULTS
Girls with AN had a significantly lower BMD than their age-matched controls. Osteopenia and osteoporosis were present even in the group with AN diagnosed within the previous 12 months. BMD correlated negatively with minimal BMI and positively with the duration of regular menses before AN onset. BGP and DPYR were significantly lower in AN patient than in the control group. Values of urine calcium of AN patients were comparable with control group, but showed a positive correlation with disease duration.


CONCLUSIONS
Reduction of bone mineral density is present in girls with short course of AN. Nutritional status is the most important predictor of BMD. Bone metabolism is decreased in the early stages of the disease.
Katedra i Klinka Endokrynologii Wieku Rozwojowego AM we Wrocławiu, Wrocław, Poland.
Ewa
E
Serafinowicz
Renata
R
Wasikowa
Zdzisława
Z
Iwanicka
Diana
D
Jedrzejuk
D015502:Absorptiometry, Photon; D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D000856:Anorexia Nervosa / Q000097:blood / Q000150:complications* / Q000378:metabolism* / Q000652:urine; D015992:Body Mass Index; D018488:Bone Demineralization, Pathologic / Q000097:blood / Q000209:etiology* / Q000378:metabolism* / Q000652:urine; D015519:Bone Density; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000503:physiopathology; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000209:etiology; D011044:Poland; D011379:Prognosis; D013997:Time Factors
D000596:Amino Acids; D015675:Osteocalcin; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase