Ras GTPases: integrins' friends or foes?
Integrins are cell-surface receptors that mediate and coordinate cellular responses to the extracellular matrix (ECM). Cellular signalling pathways can regulate cell adhesion by altering the affinity and avidity of integrins for ECM. The Ras family of small G proteins, which includes H-ras, R-ras and Rap, are important elements in cellular signalling pathways that control integrin function.
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
Kayoko
K
Kinbara
Lawrence E
LE
Goldfinger
Malene
M
Hansen
Fan-Li
FL
Chou
Mark H
MH
Ginsberg
D000818:Animals; D004789:Enzyme Activation; D005109:Extracellular Matrix / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D020668:rap GTP-Binding Proteins / Q000378:metabolism; D020703:ras GTPase-Activating Proteins / Q000378:metabolism*
D016023:Integrins; D020703:ras GTPase-Activating Proteins; D020668:rap GTP-Binding Proteins