Proline-catalysed asymmetric amination of alpha,alpha-disubstituted aldehydes: synthesis of configurationally stable enantioenriched alpha-aminoaldehydes.
Proline-catalysed amination of alpha,alpha-disubstituted racemic aldehydes with azodicarboxylates proceeds smoothly to give configurationally stable scalemic aldehydes and oxazolidinones in up to 86% ee.
Kekulé-Institut für Organische Chemie und Biochemie der Rheinischen Friedrich-Wilhelms-Universität Bonn, Gerhard-Domagk-Str. 1, D-53121 Bonn, Germany.
Henning
H
Vogt
Sylvia
S
Vanderheiden
Stefan
S
Bräse
D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry*; D000586:Amination; D000588:Amines / Q000138:chemical synthesis*; D001372:Aza Compounds / Q000737:chemistry; D002384:Catalysis; D023303:Oxazolidinones / Q000138:chemical synthesis; D011392:Proline / Q000737:chemistry*; D013237:Stereoisomerism
D000447:Aldehydes; D000588:Amines; D001372:Aza Compounds; D023303:Oxazolidinones; D011392:Proline