Hydrogel patches containing triclosan for acne treatment.
Adhesive hydrogel patches containing Triclosan (TS) were prepared as an anti-acne dosage form. Sodium polyacrylate and carboxymethylcellulose (sodium salt) were used as matrix polymers, and Al(3+), produced by the reaction of dihydroxy aluminum aminoacetate and L(+)-tartaric acid, was employed as a crosslinking agent for the negatively charged polymers. The crosslinking reactions were done at 25, 40 and 50 degrees C for predetermined time intervals. The semi-solid gels were obtained only when the reaction period was more than 12 h, but the polymer gels were fluidic with a shorter reaction. The swelling ratios increased as the reaction period was prolonged and the reaction temperature increased, indicating that the degree of the crosslinking is proportional to the reaction period and the temperature. On a scanning electron microphotograph, the crosslinked gel exhibited a honeycomb-like structure having pores of a few micrometers. The adhesive force of a patch, which could be easily attached to and peeled off facial skin, was 45.5 gmf and it increased by adding poly acrylic acid into the patch formulations. Propionibacterium acnes (ATCC 6919) growth inhibition area around the patch was not significant on an agar plate when TS content was 0.01 wt.%, but the antibacterial activity was apparent when the content was 0.05 wt.%. In vitro permeation revealed that up to 5 wt.% of Transcutol (TC) content in patch, TC, a permeation enhancer, significantly increased the amount of TS transported into hairless mouse skins but it did not substantially accelerate TS transportation into the receptors of Franz diffusion cells. Since our patches for the treatment of acne was aimed to localize TS into skins, TC content of 5 wt.% seems to be adequate for the dermal delivery of TS. The model patches in this study would be applicable to facial skins for the treatment of acne.
Lee
Tae Wan
TW
College of Pharmacy, Chung-Nam National University, Daejon, South Korea.
Kim
Jin Chul
JC
Hwang
Sung Joo
SJ
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000378:metabolism; D000269:Adhesives / Q000008:administration & dosage; D000279:Administration, Cutaneous; D000818:Animals; D005260:Female; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage* / Q000493:pharmacokinetics; D051379:Mice; D008812:Mice, Hairless; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D014260:Triclosan / Q000008:administration & dosage* / Q000493:pharmacokinetics
D000269:Adhesives; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D014260:Triclosan