Role of heterogeneity in deterministic models of drug dissolution and their statistical characteristics.
Dissolution of drugs is one of the crucial factors determining their global action in a body, and thus for any new solid dosage form its dissolution characteristics have to be established. A variety of empirical and semi-empirical models for drug dissolution is reviewed in this article. Their properties are investigated, the parameters are discussed and the role of drug heterogeneity is studied.
Institute of Physiology, Academy of Sciences of the Czech Republic, Vídenská 1082, 142 20 Prague 4, Czech Republic. lansky@biomed.cas.cz
Petr
P
Lánský
Michael
M
Weiss
D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D010599:Pharmacokinetics
D004364:Pharmaceutical Preparations