The Arg16Gly polymorphism of the beta2-adrenergic receptor and left ventricular systolic function.
BACKGROUND
beta-Adrenergic receptors (ARs), including beta1- and beta2-AR, are involved in modulation of cardiac contractility and heart rate. Arg16Gly, a functional polymorphism in the beta2-AR gene, has been reported to influence exercise capacity in heart failure patients. This study examined the association of the beta2-AR Arg16Gly polymorphism with left ventricular (LV) systolic function in a biethnic population-based sample.


METHODS
Echocardiograms and the beta2-AR Arg16Gly polymorphism were analyzed in 267 normotensive (54% African Americans) and 252 severe hypertensive (53% African Americans) adults without coronary heart disease or diabetes.


RESULTS
The frequencies of Gly16Gly16, Arg16Gly16, and Arg16Arg16 were 28.1%, 54.3%, and 17.6%, respectively, in normotensives, and 31.4%, 47.6%, and 21.0%, respectively, in hypertensives. In normotensives, the Gly16Gly16 homozygotes displayed greater fractional shortening (35.9% +/- 4.3% v 34.1% +/- 4.7% v 34.0% +/- 3.9%, P =.01), ejection fraction (65.0% +/- 5.8% v 62.5% +/- 6.4% v 62.6% +/- 5.4%, P =.01), midwall shortening (18.6% +/- 1.6% v 17.9% +/- 1.9% v 18.0% +/- 1.6%, P =.02), and stress-corrected midwall shortening (110.1% +/- 9.3% v 106.1% +/- 10.6% v 108.1% +/- 10.8%, P =.03) compared to the Arg16Gly16 and Arg16Arg16 groups. These associations were independent of age, sex, ethnicity, heart rate, body mass index, systolic blood pressure, LV end-diastolic dimension, and field center. No significant associations between the beta2-AR Arg16Gly polymorphism and echocardiographic measures were found in hypertensives.


CONCLUSIONS
The Arg16Gly polymorphism of beta2-AR may be a marker for LV chamber function and contractility in normotensive adults.
Division of Epidemiology, University of Minnesota, Minneapolis, Minnesota 55454, USA.
Weihong
W
Tang
Richard B
RB
Devereux
Dalane W
DW
Kitzman
Michael A
MA
Province
Mark
M
Leppert
Albert
A
Oberman
Paul N
PN
Hopkins
Donna K
DK
Arnett
D000328:Adult; D004452:Echocardiography; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*; D013599:Systole / Q000235:genetics; D016277:Ventricular Function, Left / Q000235:genetics*
D005819:Genetic Markers; D018343:Receptors, Adrenergic, beta-2