[Mechanism of antioxidant protection of an organism from oxidative stress].
The analysis of the literature and authors' data concerning the mechanism of antioxidant protection of the organism under conditions of "oxygen stress" is submitted. Possible mechanisms of initiation of free radical reactions with participation of oxygen and the role of hydroxyl radicals, being one of the basic factors, determining toxic action of oxygen, are considered. The methods of estimation of antiradical activity of biologically active compounds are characterized.
Shapoval
G S
GS
Institute of Bioorganic Chemistry and Petroleum Chemistry, National Academy of Sciences of Ukraine, Kyiv.
Gromovaia
V F
VF
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D005609:Free Radicals / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D017665:Hydroxyl Radical / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology
D000975:Antioxidants; D005609:Free Radicals; D017382:Reactive Oxygen Species; D017665:Hydroxyl Radical