[Effect of dihydro-qinghaosu on auto-antibody production, TNF alpha secretion and pathologic change of lupus nephritis in BXSB mice].
OBJECTIVE
To investigate the effect of dihydro-qinghaosu (DQHS) on auto-antibody production, TNF alpha secretion and pathologic change of lupus nephritis in BXSB mice and the possible mechanism of DQHS in treating systemic lupus erythematosus (SLE).


METHODS
Anti ds-DNA antibody and TNF alpha in serum of the BXSB mice were detected by enzyme linked immunosorbent assay (ELISA). Renal tissue was stained by HE and Masson.


RESULTS
In the height and moderate dose DQHS groups, as compared with the model group, levels of anti-ds-DNA antibody and serum TNF alpha were significantly lower (P < 0.05); and renal pathological change was milder.


CONCLUSIONS
DQHS could inhibit the production of anti-ds-DNA antibody and secretion of TNF alpha and improve the pathologic lesion of lupus nephritis in BXSB mice.
Department of Pharmacology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100831.
Yan-jun
YJ
Dong
Wei-dong
WD
Li
You-you
YY
Tu
D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood*; D037621:Artemisinins / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000473:pathology; D008181:Lupus Nephritis / Q000473:pathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011897:Random Allocation; D012717:Sesquiterpenes / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D000974:Antibodies, Antinuclear; D037621:Artemisinins; D007166:Immunosuppressive Agents; D012717:Sesquiterpenes; D014409:Tumor Necrosis Factor-alpha; C039060:artenimol