The endogenous langur type D retrovirus PO-1-Lu and its exogenous counterparts in macaque and langur monkeys.
PO-1-Lu, the endogenous type D retrovirus of langurs (Trachypithecus obscurus) has previously been considered a progenitor to the prototype type D retrovirus, Mason Pfizer monkey virus (M-PMV/SRV-3), that became established in macaque monkeys (Macaca spp.) following a zoonosis. This study reevaluates this hypothesis to include other exogenous SRVs. New sequence information from the gp70(SU)-encoding region of PO-1-Lu shows striking similarity to the newly identified exogenous langur retrovirus, SRV-6, recently isolated from the Hanuman Langur (Semnopithecus entellus). An unrooted, bootstrapped neighbor-joining tree derived from env gene nucleotide sequences shows PO-1-Lu and SRV-6 appear more closely related genetically to SRV-2 than SRV-1 or SRV-3 (M-PMV). This is also reflected in our observations that the M-PMV envelope glycoprotein precursor gPr86(Env) and gp70(SU) were antigenically distinct from PO-1-Lu, although the gp22(TM) glycoproteins were antigenically cross-reactive. The potential that SRV-6 represents an exogenous form of PO-1-Lu that has arisen following a recent zoonosis is discussed.
Sommerfelt
Maja A
MA
Centre for Research in Virology, Department of Microbiology and Immunology, The Gade Institute, University of Bergen, Bergen High Technology Centre, N-5020 Bergen, Norway. maja.sommerfelt@vir.uib.no
Harkestad
Nina
N
Hunter
Eric
E
D000595:Amino Acid Sequence; D000818:Animals; D030121:Betaretrovirus / Q000235:genetics* / Q000276:immunology; D002520:Cercopithecidae / Q000821:virology*; D003429:Cross Reactions; D020077:Endogenous Retroviruses / Q000235:genetics* / Q000276:immunology; D016679:Genome, Viral; D008251:Macaca / Q000821:virology*; D008969:Molecular Sequence Data; D014759:Viral Envelope Proteins / Q000276:immunology
D014759:Viral Envelope Proteins