New guaianolides from leaves and stems of Chrysanthemum boreale.
The 8-acetoxy-2-methoxy-10-hydroxy-3,11(13)-guaiaden-12,6-olide 1 and 8,10-diacetoxy-2-methoxy-3,11(13)-guaiadiene-12,6-olide 2 were isolated from Chrysanthemum boreale Makino. Compound 1 inhibited the etoposide-induced apoptosis in U 937 cells with an IC50 value 8.6 microg/mL.
Lee
Jong Rok
JR
Department of Agricultural Chemistry, Division of Applied Life Science, Gyeongsang National University, Chinju 660-701, Korea.
Yang
Min Suk
MS
Lee
Jun
J
Hwang
Seon Woo
SW
Kho
Yung Hee
YH
Park
Ki Hun
KH
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor / Q000187:drug effects; D031202:Chrysanthemum; D005047:Etoposide; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D018547:Plant Stems; D045789:Sesquiterpenes, Guaiane / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D045789:Sesquiterpenes, Guaiane; D005047:Etoposide