NACP-REP1 polymorphism is not involved in Parkinson's disease: a case-control study in a population sample from southern Italy.
Contradictory evidence has been reported on the role of the polymorphic mixed dinucleotide repeat (NACP-REP1) of the alpha-synuclein gene as a risk factor for sporadic Parkinson's disease (PD). In the present study we genotyped the NACP-REP1 polymorphism in 189 PD patients from southern Italy and 182 healthy control subjects. We failed to demonstrate an association of any NACP-REP1 allele with PD.
Spadafora
P
P
Institute of Neurological Sciences, National Research Council, Piano Lago di Mangone, Cosenza, Italy.
Annesi
G
G
Pasqua
A A
AA
Serra
P
P
Cirò Candiano
I C
IC
Carrideo
S
S
Tarantino
P
P
Civitelli
D
D
De Marco
E V
EV
Nicoletti
G
G
Annesi
F
F
Quattrone
A
A
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D018900:Dinucleotide Repeats / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics*; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D051843:Synucleins; D051844:alpha-Synuclein
D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein