Substitution of a bridgehead bromide by primary organolithium reagents.
The reaction of ketone 1 with primary organolithium reagents in THF/HMPA affords not the expected carbonyl addition product but the product of bromide substitution, in reasonable yield.
Department of Chemistry, University of Missouri-Columbia, Columbia, Missouri 65211, USA. harmatam@missouri.edu
Michael
M
Harmata
Sumrit
S
Wacharasindhu