Stereospecific and efficient alkynylation at the more hindered carbon of trisubstituted epoxides.
The stereospecific and regioselective C(3) alkynylation of trisubstituted epoxides has been achieved with lithium alkynyl trimethylaluminium ate complexes in the presence of BF3 x OEt2.
Zhao
Hongda
H
The Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA.
Pagenkopf
Brian L
BL