Metabolic engineering for the microbial production of 1,3-propanediol.
Improvements in the biological production of 1,3-propanediol, a key component of an emerging polymer business, have been realized. Utilizing genes from natural strains that produce 1,3-propanediol from glycerol, metabolic engineering has enabled the development of a recombinant strain that utilizes the lower cost feedstock D-glucose. This accomplishment bodes well for future metabolic engineering efforts and, ultimately, for increased societal benefit obtained through the production of chemicals from renewable resources.
Nakamura
Charles E
CE
DuPont Central Research & Development Experimental Station, 328/245A Wilmington, DE 19880-0328, USA. charles.e.nakamura@usa.dupont.com
Whited
Gregory M
GM
D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D001692:Biological Transport; D002384:Catalysis; D003038:Cobamides / Q000378:metabolism; D005285:Fermentation; D005947:Glucose / Q000378:metabolism; D007218:Industrial Microbiology; D011409:Propylene Glycols / Q000138:chemical synthesis / Q000378:metabolism*; D015202:Protein Engineering / Q000379:methods*
D003038:Cobamides; D011409:Propylene Glycols; C041787:1,3-propanediol; C000913:cobamamide; D005947:Glucose