[European multicenter cross-sectional study on exposure to low doses of benzene].
A cross-sectional multicenter european study has been carried out to evacuate the relations between exposure to low level of benzene and biological markers of internal dose (t,t-MA, S-PMA) and early biological effect (DNA-SSB). The research has shown significantly increased levels (adjusted for smoking habits) of the urinary excretion of t,t-MA, S-PMA and DNA-SSB in petrochemical workers (mean benzene level = 5,694 micrograms/m3) but not in filling station attendants, traffic police officers, and bus drivers compared to referent workers. Dose-response relations were detected between benzene air levels, t,t-MA, S-PMA and DNA-SSB in petrochemical workers, with significantly increased levels of DNA-SSB detected for benzene exposure levels in the range 391-1,800 micrograms/m3 (0.12-0.58 ppm).
Istituto Nazionale per la Ricerca sul Cancro, Genova.
F
F
Merlo
P A
PA
Bertazzi
C
C
Bolognesi
A
A
Colombi
S
S
Fustinoni
M
M
Buratti
P
P
Farmer
S
S
Garte
L
L
Levy
A C
AC
Pesatori
T
T
Popov
E
E
Taioli
F
F
Valerio
D
D
Consonni
D001554:Benzene / Q000009:adverse effects* / Q000378:metabolism; D005060:Europe; D006801:Humans; D016273:Occupational Exposure / Q000706:statistics & numerical data*
D001554:Benzene