[Structure and antiviral activity of adamantane-containing polymer preparation].
New water-soluble antiviral chemical agents, containing 10 to 30% of adamantane derivatives (amino-, aminopropyl-adamantane-, aminomethyl- and rimantadine), which were conjugated with polycarboxylic matrixes of the divinyl ether and maleic anhydride copolymers (DIVEMA), were developed. The polymeric drugs exhibited a low cytotoxicity (4 to 10 times less than rimantadine) and a wide spectrum of antiviral activity against influenza viruses, including both the remantadine-resistant strains of A/PR/8/34 (H1N1) and the B/Saint-Petersburg strain/71/77 as well as against herpes viruses of type 1, parainfluenza viruses of types 1 and 3 and RS-virus. A reduction of the viral infection titer in their reproduction in sensitive cells' cultures was more than 2.0 Ig ID50. Complete inhibition of viral-specific syntheses, registered by immune-enzyme assay (IEA) and by hemagglutination test was observed at low infection doses ranging from 1 to 100 ID50. The efficiency of the antiviral effect depends on a drug's molecular weight and a structure of chemical bonds between the adamantane nucleus and the polymeric matrix.
K N
KN
Kozeletskaia
L L
LL
Stotskaia
A V
AV
Serbin
K
K
Munshi
A A
AA
Sominina
O I
OI
Kiselev
D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D024882:Drug Resistance, Viral; D006564:Herpesviridae / Q000187:drug effects; D006801:Humans; D008970:Molecular Weight; D009975:Orthomyxoviridae / Q000187:drug effects / Q000276:immunology; D011108:Polymers / Q000138:chemical synthesis / Q000494:pharmacology*; D011713:Pyran Copolymer / Q000138:chemical synthesis / Q000494:pharmacology; D012136:Respiratory Syncytial Viruses / Q000187:drug effects; D018108:Respirovirus / Q000187:drug effects / Q000276:immunology; D012299:Rimantadine / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D011108:Polymers; D012299:Rimantadine; D011713:Pyran Copolymer; D000218:Adamantane