Expression of NKB1 on peripheral T cells in patients with rheumatoid arthritis.
NKB1 inhibits cytoxic activity of T lymphocytes mediated by superantigens, which is one of the contributing factors in the pathogenesis of rheumatoid arthritis (RA). In this study, we determined the expression of NKB1 on peripheral blood T cells in patients with RA. Our findings revealed that among patients with RA, NKB1(+) CD8(+ )T cells decreased significantly in comparison to controls (ratio: P < 0.05; absolute number: P < 0.005), and this decrease was not related to or influenced by HLA-Bw4 as a ligand of NKB1. This result may suggest that decreased expression of NKB1(+) CD8(+ )T cells contributes to the pathogenesis of RA mediated by the activation of CD8(+) T cells.
Juntendo University School of Medicine, Tokyo, Japan. mayuta@hkg.odn.ne.jp
Y
Y
Nakiri
H
H
Kaneko
S
S
Morimoto
J
J
Suzuki
Y
Y
Tokano
H
H
Hashimoto
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000276:immunology* / Q000503:physiopathology; D015415:Biomarkers / Q000032:analysis; D015704:CD4 Antigens / Q000276:immunology; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D015235:HLA-B Antigens / Q000276:immunology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011336:Probability; D011379:Prognosis; D011971:Receptors, Immunologic / Q000276:immunology*; D054340:Receptors, KIR; D054341:Receptors, KIR3DL1; D012016:Reference Values; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
D015415:Biomarkers; D015704:CD4 Antigens; D015235:HLA-B Antigens; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D054341:Receptors, KIR3DL1