Combination of balanced ultrafiltration with modified ultrafiltration attenuates pulmonary injury in patients undergoing open heart surgery.
OBJECTIVE
To explore the effects of ultrafiltration technique in preventing and relieving pulmonary injury in children undergoing open heart surgery and cardiopulmonary bypass (CPB).


METHODS
Thirty cases with congenital heart defects were divided into a control group and an experimental group. In the control group, conventional cardiopulmonary bypass was used without ultrafiltration; while in the experimental group, cardiopulmonary bypass with balanced ultrafiltration and modified ultrafiltration were used. Pulmonary static compliance (Cstat), airway resistance (Raw), alveolar-arterial oxygen difference (A-a DO2), hematocrit (HCT), serum albumin (Alb), interleukin-6 (IL-6), endothelia-1 (ET-1) and thromboxane (TXB2) were measured.


RESULTS
The pulmonary function was improved, HCT and serum albumin concentrations were increased, and some harmful medium-size solutes were decreased in the experimental groups compared with the control group.


CONCLUSIONS
Combination of balanced ultrafiltration with modified ultrafiltration can effectively concentrate blood, exclude harmful inflammatory mediators, and attenuate lung edema and inflammatory responsive pulmonary injury.
Department of Thoracocardiac Surgery, Children's Medical Center, Xinhua Hospital, Shanghai Second Medical University, Shanghai 200127, China. wenfeik@online.sh.cn
Huimin
H
Huang
Tingjun
T
Yao
Wei
W
Wang
Deming
D
Zhu
Wei
W
Zhang
Hong
H
Chen
Weiding
W
Fu
D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass / Q000379:methods*; D002675:Child, Preschool; D006330:Heart Defects, Congenital / Q000601:surgery; D006801:Humans; D008171:Lung Diseases / Q000517:prevention & control*; D011654:Pulmonary Edema / Q000517:prevention & control; D014462:Ultrafiltration / Q000379:methods*