A metabolic basis for Alzheimer disease.
Most studies of Alzheimer's disease (AD) have focused on a single precipitating alteration as the etiological event rather than global changes closely linked to aging. Recent evidence suggests that the most significant of these global changes are metabolic. Here we present data indicating that metabolic rate, nutrition, and neuronal size are all early indicators of AD. Understanding the cellular and molecular basis for these changes may open a new dimension to understanding AD.
Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA. gxp7@po.cwru.edu
George
G
Perry
Akihiko
A
Nunomura
Arun K
AK
Raina
Gjumrakch
G
Aliev
Sandra L
SL
Siedlak
Peggy L R
PL
Harris
Gemma
G
Casadesus
Robert B
RB
Petersen
William
W
Bligh-Glover
Elizabeth
E
Balraj
Grace J
GJ
Petot
Mark A
MA
Smith
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D050260:Carbohydrate Metabolism; D048429:Cell Size; D004032:Diet; D006801:Humans; D009474:Neurons / Q000473:pathology