Lincomycin, cultivation of producing strains and biosynthesis.
Lincomycin and its derivatives are antibiotics exhibiting biological activity against Gram-positive bacteria. The semi-synthetic chlorinated lincomycin derivative is used in clinical practice. The chemical structure of lincosamide antibiotics, cultivation of producing strains and analytical procedures used for separation and isolation of these compounds are described in this review. Biosynthesis of lincomycin and related compounds and its genetic control are briefly discussed.
Spízek
J
J
Institute of Microbiology, Academy of Sciences of the Czech Republic, Vídenská 1083, 142 20 Prague 4, Czech Republic. spizek@biomed.cas.cz
Rezanka
T
T
D018533:Biomass; D002845:Chromatography; D019343:Citric Acid / Q000378:metabolism; D023061:Gene Order; D005798:Genes, Bacterial; D005947:Glucose / Q000378:metabolism; D008034:Lincomycin / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification; D005810:Multigene Family; D013302:Streptomyces / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D013997:Time Factors
D019343:Citric Acid; D008034:Lincomycin; D005947:Glucose