The ICF syndrome, a DNA methyltransferase 3B deficiency and immunodeficiency disease.
Only one human disease that involves Mendelian inheritance of immunodeficiency and aberrant DNA methylation has been identified. This is a rare chromosome breakage disease called the immunodeficiency, centromeric region instability, and facial anomalies syndrome (ICF). Its diagnostic characteristics are agammaglobulinemia with B cells as well as DNA rearrangements targeted to the centromere-adjacent heterochromatic region (qh) of chromosomes 1, 16, and sometimes 9 in mitogen-stimulated lymphocytes. These rearrangement-prone regions show DNA hypomethylation in all examined ICF cell populations. This review summarizes our knowledge about the immunological symptoms of ICF; the nature of DNMT3B mutations in ICF patients; the phenotypes of DNA hypomethylation mutants in humans, mice, and Arabidopsis; the epigenetics of ICF; and ICF-specific RNA expression and cell-surface antigen expression in lymphoblastoid cell lines. Comparisons of ICF and control lymphoblastoid cell lines and ICF patients' symptoms suggest an involvement of DNA methylation in the late stages of lymphocyte maturation.
Ehrlich
Melanie
M
Human Genetics Program and Department of Biochemistry, Tulane Cancer Center, Tulane Medical School, New Orleans, LA 70112, USA. ehrlich@tulane.edu
D000818:Animals; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology; D002503:Centromere / Q000235:genetics; D043171:Chromosomal Instability; D019465:Craniofacial Abnormalities / Q000235:genetics; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000172:deficiency* / Q000235:genetics*; D019175:DNA Methylation; D006801:Humans; D007136:Immunoglobulins / Q000172:deficiency; D007153:Immunologic Deficiency Syndromes / Q000201:enzymology* / Q000235:genetics*; D051379:Mice; D018448:Models, Immunological; D009154:Mutation; D013601:T-Lymphocytes / Q000276:immunology; D000097584:DNA Methyltransferase 3B
D004248:DNA (Cytosine-5-)-Methyltransferases; D007136:Immunoglobulins; D000097584:DNA Methyltransferase 3B