Inhibitors of the CDC25 phosphatases.
As essential cell cycle regulators, the CDC25 phosphatases are currently considered as potential targets for the development of novel therapeutic approaches. Here, we review the function and regulation of CDC25 phosphatases, their involvement in cancer and Alzheimer's disease, and the properties of several recently identified inhibitors.
Institut Henri Beaufour, Beaufour-Ipsen, 5 Avenue du Canada, Les Ulis 91966, France.
Grégoire Pierre
GP
Prevost
Marie-Christine
MC
Brezak
Françoise
F
Goubin
Odile
O
Mondesert
Marie-Odile
MO
Galcera
Muriel
M
Quaranta
Frédéric
F
Alby
Olivier
O
Lavergne
Bernard
B
Ducommun
D000544:Alzheimer Disease / Q000188:drug therapy / Q000201:enzymology*; D000818:Animals; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology*; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000639:trends; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology*; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism
D004791:Enzyme Inhibitors; D020687:cdc25 Phosphatases