CYP2C19-mediated (S)-mephenytoin 4'-hydroxylation assayed by high-performance liquid chromatography with radiometric detection.
Crespi
C L
CL
GENTEST Corporation, Woburn, MA, USA.
Chang
T K
TK
Waxman
D J
DJ
D001189:Aryl Hydrocarbon Hydroxylases / Q000032:analysis / Q000378:metabolism*; D001681:Biological Assay / Q000379:methods*; D002250:Carbon Radioisotopes / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D065731:Cytochrome P-450 CYP2C19; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D006900:Hydroxylation; D008617:Mephenytoin / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000032:analysis / Q000378:metabolism*
D002250:Carbon Radioisotopes; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D008617:Mephenytoin