Comparison of the effect of propofol and sevoflurane on the urethral pressure profile in healthy female dogs.
OBJECTIVE
To compare the effects of propofol and sevoflurane on the urethral pressure profile in female dogs.


METHODS
10 healthy female dogs.


METHODS
Urethral pressure profilometry was performed in awake dogs, during anesthesia with sevoflurane at 1.5, 2.0, and 3.0% end-tidal concentration, and during infusion of propofol at rates of 0.4, 0.8, and 1.2 mg/kg/min. A consistent plane of anesthesia was maintained for each anesthetic protocol. Maximum urethral pressure, maximum urethral closure pressure, functional profile length, and functional area were measured.


RESULTS
Mean maximum urethral closure pressure of awake dogs was not significantly different than that of dogs anesthetized with propofol at all infusion rates or with sevoflurane at 1.5 and 2.0% end-tidal concentration. Functional area in awake dogs was significantly higher than in anesthetized dogs. Functional area of dogs during anesthesia with sevoflurane at 3.0% end-tidal concentration was significantly lower than functional area for other anesthetic protocols. Individual differences in the magnitude of effects of propofol and sevoflurane on urethral pressures were observed.


CONCLUSIONS
Sevoflurane is an alternative to propofol for anesthesia in female dogs undergoing urethral pressure profilometry. Use of these anesthetics at appropriate administration rates should reliably distinguish normal from abnormal maximum urethral closure pressures and functional areas. Titration of anesthetic depth is a critical component of urodynamic testing.
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Julie K
JK
Byron
Philip A
PA
March
Stephen P
SP
DiBartola
Dennis J
DJ
Chew
William W
WW
Muir
D018685:Anesthetics, Inhalation / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D005260:Female; D008738:Methyl Ethers / Q000494:pharmacology*; D011312:Pressure; D015742:Propofol / Q000494:pharmacology*; D012016:Reference Values; D000077149:Sevoflurane; D014521:Urethra / Q000187:drug effects / Q000502:physiology*; D014563:Urodynamics / Q000187:drug effects / Q000502:physiology
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol