[Experimental evaluation of the wound healing dynamics].
The experimental clinical investigation of the influence of systemic enzymotherapy on the course of the wound process was carried out in rats and in clinic. The rats of the experimental group have demonstrated more rapid debridement of the wound from blood clots and tissue detritus, intensive formation of granular tissue and its ripening. The experimental investigation has shown that using the preparation of systemic enzymotherapy (Vobenzyme) stimulates processes of healing at the expense of quicker changing the inflammation phases as well as prevents the development of early and late complications on the side of postoperative wounds. It was confirmed by clinical observations in 36 patients from 4 to 14 years of age.
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D034861:Abdominal Wall / Q000473:pathology; D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000494:pharmacology*; D000293:Adolescent; D000818:Animals; D002648:Child; D002675:Child, Preschool; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006867:Hydrolases / Q000627:therapeutic use*; D007813:Laparotomy; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control; D051381:Rats; D012431:Rutin / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
D000276:Adjuvants, Immunologic; D004338:Drug Combinations; D012431:Rutin; C023295:Wobenzym; D006867:Hydrolases