Transformation of D-glucose into 1D-3-deoxy-3-hydroxymethyl-myo-inositol by stereocontrolled intramolecular Henry reaction.
[reaction: see text] An intramolecular Henry cyclization provides a promising new strategy for the transformation of nitroheptofuranoses into deoxyhydroxymethylinositols. This method has allowed a stereospecific transformation of d-glucose into 1D-3-deoxy-3-hydroxymethyl-myo-inositol.
Soengas
Raquel G
RG
Departamento de Química Orgánica, Universidade de Santiago, 15782 Santiago de Compostela, Spain.
Estévez
Juan C
JC
Estévez
Ramón J
RJ
D005947:Glucose / Q000378:metabolism*; D007294:Inositol / Q000031:analogs & derivatives* / Q000737:chemistry*; D013237:Stereoisomerism
C493876:1D-3-deoxy-3-hydroxymethyl-myo-inositol; D007294:Inositol; D005947:Glucose