Meta and pooled analysis of European coeliac disease data.
Four full genome scans have been carried out by the partners of the European cluster on coeliac disease as well as follow-up studies of candidate regions. No region outside HLA showed significant linkage to the disease in any single study. We first applied a meta-analysis based on a modification of Genome Screen Meta-Analysis to take into account the different linkage statistics, the arbitrariness of bin cutoff points, as well as the sample size of each study. We then performed a pooled linkage analysis of all families and raw genotypes. Besides the HLA region, already known to harbour a risk factor for coeliac disease, both approaches leave very little doubt on the presence of a genetic risk factor in the 5q31-33 region. This region was suggested by several individual studies, but did not reach statistical values high enough to be conclusive when data sets were analysed separately.
Babron
Marie-Claude
MC
1INSERM U535, Villejuif, France. babron@vjf.inserm.fr
Nilsson
Staffan
S
Adamovic
Svetlana
S
Naluai
Asa Torinsson
AT
Wahlström
Jan
J
Ascher
Henry
H
Ciclitira
Paul J
PJ
Sollid
Ludvig M
LM
Partanen
Jukka
J
Greco
Luigi
L
Clerget-Darpoux
Françoise
F
D002446:Celiac Disease / Q000208:ethnology / Q000235:genetics*; D002874:Chromosome Mapping; D003198:Computer Simulation; D005060:Europe; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008126:Lod Score; D015201:Meta-Analysis as Topic
D005819:Genetic Markers; D006680:HLA Antigens