The role of cytosolic phospholipase A2 in cell cycle progression.
Cytosolic phospholipase A2 (cPLA2) cleaves fatty acids from the sn-2 position of phospholipids resulting in the release of arachidonic acid. cPLA2 is activated upon phosphorylation, followed by a Ca(2+)-dependent translocation to cellular membranes. The activity of cPLA2 has been demonstrated to fluctuate during the M, G1 and S-phases of the cell cycle, and it has been shown recently that inhibition of the relatively high activity during the initial phases of the cell cycle results in a drastic reduction in S-phase entry. These findings demonstrate that in addition to a role in the inflammatory response, cPLA2 plays also an important regulatory role in cell cycle progression.
Boonstra
Johannes
J
Department of Molecular Cell Biology, University Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands.
van Rossum
Gerda S
GS
D000818:Animals; D002451:Cell Compartmentation / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003600:Cytosol / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D010741:Phospholipases A / Q000037:antagonists & inhibitors / Q000378:metabolism*; D054467:Phospholipases A2; D010743:Phospholipids / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D016196:S Phase / Q000502:physiology
D018797:Cell Cycle Proteins; D004791:Enzyme Inhibitors; D010743:Phospholipids; D010741:Phospholipases A; D054467:Phospholipases A2