Membrane-type 1 matrix metalloproteinase and cell migration.
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is an integral membrane proteinase that performs processing of cell surface proteins and degradation of extracellular matrix (ECM) components. Through these proteolytic events, MT1-MMP regulates various cellular functions, including ECM turnover, promotion of cell migration and invasion, and morphogenic responses to extracellular stimuli. MT1-MMP has to be regulated strictly to accomplish its function appropriately at various steps, including at the transcriptional and post-translational levels. MT1-MMP was originally identified as an invasion-promoting enzyme expressed in malignant tumour cells, and also as a specific activator of proMMP-2, which is believed to play a role in invasion of the basement membrane. Since then, it has attracted attention as a membrane-associated MMP that promotes cancer cell invasion and angiogenesis by endothelial cells. Although MT1-MMP has now become one of the best characterized enzymes in the MMP family, there remain numerous unanswered questions. In this chapter, we summarize our recent findings on how MT1-MMP is regulated during cell migration, and how cell migration is regulated by MT1-MMP.
Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokane-dai, Minato-ku, Tokyo 108-8639, Japan. mseiki@ims.u-tokyo.ac.jp
Motoharu
M
Seiki
Hidetoshi
H
Mori
Masahiro
M
Kajita
Takamasa
T
Uekita
Yoshifumi
Y
Itoh
D002465:Cell Movement / Q000502:physiology*; D004705:Endocytosis; D018960:Hyaluronan Receptors / Q000502:physiology; D020781:Matrix Metalloproteinase 1 / Q000502:physiology*
D018960:Hyaluronan Receptors; D020781:Matrix Metalloproteinase 1