Emperipolesis in a case of B-cell lymphoma: a rare phenomenon outside of Rosai-Dorfman disease.
We describe a case of a diffuse large B-cell lymphoma with extensive emperipolesis phenomenon. Light microscopy revealed numerous CD68-positive/S-100-negative histiocytes containing viable neoplastic hematopoietic cells in their cytoplasm. Electron microscopy confirmed these findings. In this case, there was no evidence of Rosai-Dorfman disease either clinically or histologically. This report emphasizes that emperipolesis is not restricted to Rosai-Dorfman disease and can be found in other conditions including non-Hodgkin lymphomas.
Lopes
Lisandro F
LF
Department of Pathology, Medical School, State University of Sao Paulo, Sao Paula, Brazil.
Bacchi
Maura M
MM
Coelho
Kunie I
KI
Filho
Armando Antico
AA
Bacchi
Carlos E
CE
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D003593:Cytoplasm / Q000648:ultrastructure*; D015618:Histiocytosis, Sinus / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000648:ultrastructure; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D008297:Male; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor