Concurrent poststreptococcal glomerulonephritis and autoimmune hemolytic anemia.
We describe three cases of poststreptococcal glomerulonephritis (PSGN) associated with autoimmune hemolytic anemia. Along with the classic findings of PSGN, the patients had a positive direct antiglobulin test. Two patients had a cold-reacting anti-I autoantibody. This is the first description of this association. Autoimmune hemolytic anemia should be considered in children with PSGN and significant anemia or signs of hemolysis.
Department of Pediatrics (Nephrology), Medical College of Wisconsin and Children's Hospital of Wisconsin, Wisconsin 53226, USA. Lgreen@mcw.edu
Larry A
LA
Greenbaum
Bryce A
BA
Kerlin
Scott
S
Van Why
Rowena C
RC
Punzalan
Beth A
BA
Trost
Cynthia G
CG
Pan
J Paul
JP
Scott
D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications*; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005921:Glomerulonephritis / Q000209:etiology*; D006461:Hemolysis; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D013290:Streptococcal Infections / Q000150:complications*
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies