Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines.
Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). Doxycycline inhibited SE-stimulated T-cell proliferation and production of cytokines and chemokines by human peripheral blood mononuclear cells. These results suggest that the antibiotic doxycycline has anti-inflammatory effects and is therapeutically useful for mitigating the pathogenic effects of SE.
Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702-5011, USA. Teresa.Krakauer@det.amedd.army.mil
Teresa
T
Krakauer
Marilyn
M
Buckley
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents; D001427:Bacterial Toxins / Q000494:pharmacology; D002499:Centrifugation, Density Gradient; D018925:Chemokines / Q000096:biosynthesis*; D016207:Cytokines / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000494:pharmacology*; D004768:Enterotoxins / Q000494:pharmacology; D005098:Exotoxins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D013210:Staphylococcus / Q000187:drug effects / Q000378:metabolism*; D018089:Superantigens / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D001427:Bacterial Toxins; D018925:Chemokines; D016207:Cytokines; D004768:Enterotoxins; D005098:Exotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal; D004318:Doxycycline