Proteome analysis of mesencephalic tissues: evidence for Parkinson's disease.
Proteome analysis is a powerful methodology to investigate protein expression in tissues involved in diseases not linked to particular genetic defects. To date, this technique has a limited number of applications in the field of neurodegenerative disorders. We decided therefore to investigate by this approach autoptic mesencephalic tissues of patients with idiopathic Parkinson's disease as well as control specimens from healthy subjects.
Basso
M
M
Department of Structural and Functional Biology, and Center of Neuroscience, University of Insubria, via Alberto da Giussano 12, Busto Arsizio (VA), Italy.
Giraudo
S
S
Lopiano
L
L
Bergamasco
B
B
Bosticco
E
E
Cinquepalmi
A
A
Fasano
M
M
D015153:Blotting, Western / Q000379:methods; D030562:Databases, Protein; D004093:Dihydropteridine Reductase / Q000378:metabolism; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism; D010300:Parkinson Disease / Q000175:diagnosis / Q000378:metabolism*; D020543:Proteome / Q000032:analysis*; D013378:Substantia Nigra / Q000737:chemistry* / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism; D051843:Synucleins; D025801:Ubiquitin / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
D009419:Nerve Tissue Proteins; D020543:Proteome; D051843:Synucleins; D025801:Ubiquitin; D013482:Superoxide Dismutase; D004093:Dihydropteridine Reductase; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein