The clinical significance of cortical atrophy and ventricular enlargement in schizophrenia.
Ventricular enlargement and cortical atrophy are found in some schizophrenic patients. Although studies are inconclusive about the relationship between these brain abnormalities and schizophrenic symptoms, subtypes or genetic history, there may be a relationship with early brain insult or developmental abnormality. There is a relationship between the presence of ventricular enlargement and cortical atrophy with neuropsychological impairment such that the presence of these factors (ventriculomegaly, cortical atrophy, and neuropsychological impairment) in a schizophrenic individual may have a negative impact upon outcome. Clinical guidelines are presented.
Bigler
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Austin Neurological Clinic and Department of Psychology, University of Texas at Austin, 78705, USA.