Robust mixed 10/12 helices promoted by "alternating chirality" in a new family of C-linked carbo-beta-peptides.
The C-linked carbo-beta-peptides, oligomers of a new class of C-linked carbo-beta3-amino acids, have been shown to generate mixed 12/10 and 10/12 helices. The design involves use of "alternating chirality" of the epimeric (at the amine center) monomers to control the stability of these helices. The observation of stable 12/10 helix in a tripeptide and 10/12 helix in a tetrapeptide is unprecedented.
Indian Institute of Chemical Technology, Hyderabad 500 007, India. esmvee@iict.ap.nic.in
Gangavaram V M
GV
Sharma
K Ravinder
KR
Reddy
Palakodety Radha
PR
Krishna
A Ravi
AR
Sankar
K
K
Narsimulu
S Kiran
SK
Kumar
P
P
Jayaprakash
B
B
Jagannadh
A C
AC
Kunwar
D002942:Circular Dichroism; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013237:Stereoisomerism
D009842:Oligopeptides