Expression of the endoplasmic reticulum chaperone GRP94 gene in ischemic gerbil brain.
GRP94 (glucose regulated protein 94) gene expression in the ischemic-hippocampus of gerbils, which was induced by a temporary occlusion of the bilateral common carotid arteries (CCAs), was tested by Northern blot analysis. The maximum GRP94 gene expression level was detected at the occipital lobe 10 min after the induction of ischemia. In the hippocampus, GRP94 gene expression reached a maximum 15 min after inducing ischemia. Following reperfusion, the maximum expression level was shown at 12 h and continuing thereafter.
Department of Emergency Medicine, Chungnam National University Hospital, Taejon 301-721, Korea.
Seung-Whan
SW
Kim
Soojung
S
Park
Kwan-Hee
KH
You
O-Yu
OY
Kwon
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000235:genetics; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D002546:Ischemic Attack, Transient / Q000235:genetics*; D007700:Kinetics; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D018832:Molecular Chaperones / Q000235:genetics; D015424:Reperfusion; D013997:Time Factors
D018840:HSP70 Heat-Shock Proteins; D008565:Membrane Proteins; D018832:Molecular Chaperones; C018551:glucose-regulated proteins