[Benzimidazole derivative inhibition of the mutagenic activity of 2-aminoanthracene].
The antimutagenic activity of a new benzimidazole derivative that has antioxidative properties was found in the Salmonella/microsome test. This compound reduced the level histidine revertants induced by the promutagen and carcinogen 2-aminoanthracene. Inhibition of the mutagenicity of 2-aminoanthracene appears to be associated with the inactivation of its genotoxic metabolites. The capacity of the benzimidazole derivative for antimutagenic effects is possibly due to a dihydroxyphenyl radical that is present in its structure.
Zinov'eva
V N
VN
Ostrovskiĭ
O V
OV
Anisimova
V A
VA
Spasov
A A
AA
D000818:Animals; D000873:Anthracenes / Q000494:pharmacology*; D016587:Antimutagenic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D000873:Anthracenes; D016587:Antimutagenic Agents; D000975:Antioxidants; D001562:Benzimidazoles; D009153:Mutagens; C006593:2-anthramine