Influence of HLA class II molecules on the outcome of hepatitis B virus infection in population of Zhejiang Province in China.
OBJECTIVE
To investigate the correlation between HLA class II molecules and the different outcome of viral hepatitis B.


METHODS
Thirty patients with chronic hepatitis B and 56 subjects who had spontaneously recovered from HBV infection in Zhejiang were enrolled in this investigation. HLA class II molecules types and alleles were determined by PCR-ssp.


RESULTS
HLA-DR12 was found in 21 of the 56 subjects (38%) recovered from hepatitis B, compared to 3 of the 30 patients with chronic hepatitis B [10%, relative risk (rr), 0.19; Pcorr<0.025]. The frequency of the allele of HLA-DR12 DRB1*1201 was higher in the subjects recovered from hepatitis B infection (32%) than in the patients with chronic hepatitis B (3%; rr, 0.07; Pcorr<0.005). On the contrary, more HLA-DR9 was detected in the patients with chronic hepatitis B (43%) than in the subjects who recovered from hepatitis B infection (18%; rr, 3.52; Pcorr<0.025). HLA-DQ9 was also detected with a higher frequency in the patients with chronic hepatitis B (43%) than in the subjects who recovered from hepatitis B (20%; rr, 3.13; Pcorr<0.05).


CONCLUSIONS
The HLA class II molecule DR12 and its allele DRB1*1201 are associated with protection against chronic hepatitis B in Zhejiang Province, China. HLA-DR9 and DQ9 are associated with chronicity of HBV infection.
Organ Transplantation Center Laboratory, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. xueqinm@hotmail.com
Xue-Qin
XQ
Meng
Hu-Guang
HG
Chen
Yi-Lin
YL
Ma
Ke-Zhou
KZ
Liu
D000328:Adult; D000483:Alleles; D002681:China; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D059810:HLA-DR Serological Subtypes; D059811:HLA-DRB1 Chains; D019694:Hepatitis B, Chronic / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012075:Remission, Spontaneous
D006683:HLA-DQ Antigens; C415982:HLA-DQ9 antigen; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C082411:HLA-DR12 antigen; C038988:HLA-DR9 antigen; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II