A case of mixed connective tissue disease showing a lymphoid follicle in muscle pathology.
We report a 74-year-old man suffering from mixed connective tissue disease (MCTD) accompanied by a lymphoid follicle in muscle pathology. He showed proximal muscle weakness and arthritis in finger joints. His laboratory findings were characteristic of MCTD. Prednisolone administration favorably improved his symptoms. A lymphoid follicle is a rare pathological finding in inflammatory myopathies. The immunohistochemical findings suggest that the lymphoid follicle would be involved in the specific role for the pathogenesis of MCTD.
Department of Neurology, Gunma University School of Medicine, 3-39-22 Showa-machi, 371-8511 Maebashi, Japan.
Chieko
C
Inoue
Yoshio
Y
Ikeda
Makoto
M
Tanaka
Yuka
Y
Sakazume
Koichi
K
Okamoto
D000368:Aged; D006801:Humans; D008221:Lymphoid Tissue / Q000473:pathology*; D008297:Male; D008947:Mixed Connective Tissue Disease / Q000473:pathology*; D018482:Muscle, Skeletal / Q000473:pathology*