Behçet's disease: the first Mongolian case in literature showing HLA B51, MICA gene type *5/*6.
Behçet's disease is a chronic multi-systemic disease of unknown origin that includes mucocutaneous, ocular, cardiac, vascular, renal, gastrointestinal, neurologic and cutaneous involvement. The disease is spread throughout the world, but it is most prevalent in the eastern Mediterranean region-along the Silk Road-, and in Japan, China, and Korea. Recently, we treated a Mongolian patient who had complete-type Behçet's disease. As far as we know, this case is the first report of a Mongolian with Behçet's disease in the English literature. HLA typing in this patient revealed A2, A24;B51, B35; Cw4, Cw7; DR9, DR11. Study of the MICA genetype showed *5, *6 positive. Our data provided adequate evidence, from an epidemiological aspect, to support the belief that Behçet's disease is most prevalent along the old Silk Road.
Chung
Yae Lee
YL
Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea.
Bang
Dong Sik
DS
Lee
Eun-So
ES
Lee
Sung Nack
SN
Mok
Jee Won
JW
Park
Kyung Sook
KS
D000328:Adult; D000483:Alleles; D001528:Behcet Syndrome / Q000235:genetics* / Q000276:immunology; D005838:Genotype; D015235:HLA-B Antigens / Q000235:genetics*; D059949:HLA-B51 Antigen; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male
D015235:HLA-B Antigens; D059949:HLA-B51 Antigen; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A