Total synthesis of the highly potent anti-HIV natural product daurichromenic acid along with its two chromane derivatives, rhododaurichromanic acids A and B.
[reaction: see text] The highly potent anti-HIV natural product daurichromenic acid was successfully synthesized in only five steps with 49% overall yield. The key step in the synthetic strategy involves a microwave-assisted tandem condensation and intramolecular S(N)2'-type cyclization to form the 2H-benzopyran core structure.
Kang
Ying
Y
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, Iowa 52242, USA.
Mei
Yan
Y
Du
Yuguo
Y
Jin
Zhendong
Z
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002839:Chromans / Q000138:chemical synthesis* / Q000737:chemistry
D019380:Anti-HIV Agents; D002839:Chromans; C489925:daurichromenic acid; C484981:rhododaurichromanic acid A; C484982:rhododaurichromanic acid B