Genetics of teratocarcinoma transplantation. II. Effect of a semidominant H-2-linked gene lying outside the immediate major histocompatibility complex on tumor formation by the embryonal carcinoma cell line F9 in H-2 congenic pairs.
H-2 substitutions on the B6 and AKR backgrounds have been found to decrease allograft resistance to the embryonal carcinoma cell line F9. (C57BL/6 x B6.AK-H-2k)F1 and (C57BL/6 x AKR.B6-H-2b)F1 animals show resistance intermediate to that of the respective parental strains and this result, along with that from F2 analyses, suggests that the resistance differential in each congenic pair is under the control of a single semidominant locus. In the C57BL/6 congenic pair, the locus has been shown to lie outside of the H-2, Qua2/3, PGK-2 region of the 17th chromosome.
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Laboratoire d'Immunologie et de Virologie des Tumeurs, INSERM U 152, Hôpital Cochin, 27, rue du Faubourg Saint Jacques, 76674 Paris, France.
D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods; D003433:Crosses, Genetic; D051379:Mice; D008806:Mice, Inbred AKR; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation / Q000276:immunology* / Q000473:pathology; D018243:Teratocarcinoma / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D014407:Tumor Cells, Cultured