Pathophysiology of pre-eclampsia: update on the role of nitric oxide.
Women with chronic hypertension and pregnancy-induced hypertension are at substantial risk for developing pre-eclampsia/eclampsia, a disease with high fetomaternal morbidity and mortality. However, the etiology of this disease is still unknown. In this article, recent concepts on the pathophysiology of pre-eclampsia, with special attention to the role of nitric oxide, are reviewed.
Kashiwagi
Maki
M
Department of Obstetrics and Gynecology, Clinic of Obstetrics, University Hospital Zurich, Frauenklinikstrasse 10, 8091 Zurich, Switzerland. maki.kashiwagi@usz.ch
Zimmermann
Roland
R
Beinder
Ernst
E
D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000503:physiopathology; D008429:Maternal Welfare; D009569:Nitric Oxide / Q000172:deficiency / Q000502:physiology; D010920:Placenta / Q000378:metabolism / Q000503:physiopathology; D011225:Pre-Eclampsia / Q000378:metabolism / Q000503:physiopathology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000378:metabolism / Q000503:physiopathology
D009569:Nitric Oxide