Bacteriocidal activity of garlic powder against Bacillus anthracis.
The antibacterial activity of garlic powder was examined against Bacillus anthracis using agar plate cultivation and test tube methods. On the agar plate test, 1-5% garlic powder inhibited the growth of B. anthracis and Escherichia coli O157 used as references. A 1% water solution of garlic powder in the test tube method killed B. anthracis at 10(7) cfu/mL within 3 h of treatment at room temperature. A number of intestinal bacteria in a BALB/c mouse decreased after the oral administration of 1 mL of 1%, garlic powder solution once a day for 3 d. These results suggest that the oral administration of garlic powder is effective against pathogenic bacteria invasion into the intestine as an infection.
Sasaki
Jin-ichi
J
Department of Medical Technology, Hirosaki University School of Health Sciences, Honcho, Hirosaki 036-8564, Japan. jisasaki@cc.hirosaki-u.ac.jp
Kita
Jyun-ichi
J
D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001408:Bacillus anthracis / Q000187:drug effects* / Q000254:growth & development; D015169:Colony Count, Microbial; D005737:Garlic / Q000737:chemistry; D007700:Kinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D010936:Plant Extracts