Successful cidofovir treatment of adenovirus-associated hemorrhagic cystitis and renal dysfunction after allogenic bone marrow transplant.
We present a patient who developed hemorrhagic cystitis and renal dysfunction after unrelated bone marrow transplantation. Polyoma BK virus and adenovirus 11 were detected in the urine. Vidarabine was administered without effect. Relatively low dose cidofovir was efficacious. Renal function improved, and the urinary secretion of adenovirus stopped.
Department of Pediatrics, Sapporo Medical University School of Medicine, Hokkaido, Japan.
Naoki
N
Hatakeyama
Nobuhiro
N
Suzuki
Tooru
T
Kudoh
Tsukasa
T
Hori
Nobuo
N
Mizue
Hiroyuki
H
Tsutsumi
D058186:Acute Kidney Injury / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D000256:Adenoviridae / Q000187:drug effects* / Q000302:isolation & purification; D000257:Adenoviridae Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000379:methods; D000077404:Cidofovir; D003556:Cystitis / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D003596:Cytosine / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D004279:DNA, Viral / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006417:Hematuria / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D008297:Male; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000008:administration & dosage*; D016133:Polymerase Chain Reaction; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000628:therapy; D018570:Risk Assessment; D014184:Transplantation, Homologous / Q000009:adverse effects; D016896:Treatment Outcome
D004279:DNA, Viral; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir