Effect of curing conditions and plasticizer level on the release of highly lipophilic drug from coated multiparticulate drug delivery system.
The study aimed to investigate the effect of triethyl citrate (TEC) plasticizer level (10, 15, and 20%), curing temperature (40, 50, and 60 degrees C) and time (0 to 168 h) on the release of a highly lipophilic drug bumetanide from pellets coated with methacrylate ester copolymer (Eudragit RS). Bumetanide was layered onto sugar pellets followed by coating with 6% Eudragit RS with and without hydroxypropyl methyl cellulose (HPMC) seal coat using Wurster Fluid Bed equipment. Coated pellets were stored for 3 months at room temperature and the release was tested in USP purified water. At 10% TEC level, increasing curing time and temperature lead to slower drug release. At 15 and 20% TEC levels, curing initially decreased drug release followed by increase in the release at longer curing time and higher temperature. Drug release from coated pellets plasticized with 15% TEC and completely cured followed zero order kinetic models. At plasticizer level of 20%, bumetanide release from the completely cured pellets was better modeled using the Higuchi's equation reflecting possible drug migration during curing. Storage led to an increase in drug release. The use of HPMC seal coat stabilized drug release after storage. It was concluded that bumetanide migration into Eudragit RS film coat was the main cause of the accelerated release after curing and storage. The drug migration during storage at room temperature was prevented by seal coating the pellets with HPMC.
Industrial Pharmacy Program, College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, USA. ehab.hamed@cimalabs.com
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D000180:Acrylic Resins / Q000737:chemistry / Q000493:pharmacokinetics; D001682:Biological Availability; D002034:Bumetanide / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002951:Citrates / Q000032:analysis / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D004356:Drug Storage; D007785:Lactose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D010078:Oxazines; D010968:Plasticizers / Q000032:analysis* / Q000493:pharmacokinetics; D012995:Solubility; D013696:Temperature; D013997:Time Factors
D000180:Acrylic Resins; D002951:Citrates; D010078:Oxazines; D010968:Plasticizers; D002034:Bumetanide; C050528:Eudragit RS; C023001:ethyl citrate; D008747:Methylcellulose; C071191:MK 458; D007785:Lactose