Red ginseng inhibits exercise-induced increase in 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in dorsal raphe of rats.
Red ginseng has been used as an ergogenic aid for endurance exercise. In this study, the effect of aqueous extract of Red ginseng on the endurance in treadmill exercise and 5-hydroxytryptamine (serotonin) synthesis and tryptophan hydroxylase expression in the dorsal raphe of rats were studied. Rats receiving Red ginseng showed increased time to exhaustion for treadmill running, and Red ginseng treatment inhibited exercise-induced increases in 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe. These results suggest that the suppressive effect of Red ginseng on serotonin level during exercise is a possible ergogenic mechanism of Red ginseng.
Min
Yeong-Ki
YK
Department of Oriental Rehabilitation Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Korea.
Chung
Seok-Hee
SH
Lee
Jong-Soo
JS
Kim
Sung-Soo
SS
Shin
Hyun-Dae
HD
Lim
Baek-Vin
BV
Shin
Min-Chul
MC
Jang
Mi-Hyeon
MH
Kim
Ee-Hwa
EH
Kim
Chang-Ju
CJ
D000818:Animals; D007150:Immunohistochemistry; D008297:Male; D005894:Panax / Q000737:chemistry*; D005082:Physical Exertion / Q000502:physiology*; D010936:Plant Extracts / Q000494:pharmacology; D011903:Raphe Nuclei / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000096:biosynthesis*; D014365:Tryptophan Hydroxylase / Q000096:biosynthesis*
D010936:Plant Extracts; D012701:Serotonin; D014365:Tryptophan Hydroxylase