Vascular surgery using argatroban in a patient with a history of heparin-induced thrombocytopenia.
For patients with a history of heparin-induced thrombocytopenia (HIT) who undergo cardiac or vascular surgery, the optimal anticoagulation substitute for heparin has yet to be established. Recombinant hirudin has been recommended; however, this agent is unsuitable for patients with renal dysfunction. Argatroban was used in the present patient who had a history of HIT and renal dysfunction and required peripheral vascular surgery. Argatroban was easy to monitor and control, regardless of renal function, and has advantages over other anticoagulants for such patients.
Department of Cardiovascular Surgery, Tenri Hospital, Japan. tokuda@mxb.mesh.ne.jp
Yoshiyuki
Y
Tokuda
Masahiko
M
Matsumoto
Takaaki
T
Sugita
Junichiro
J
Nishizawa
Katsuhiko
K
Matsuyama
Kazunori
K
Yoshida
Takehiko
T
Matsuo
D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use; D001120:Arginine / Q000031:analogs & derivatives; D013504:Cardiovascular Surgical Procedures / Q000379:methods; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D019990:Perioperative Care; D016491:Peripheral Vascular Diseases / Q000188:drug therapy / Q000601:surgery*; D010875:Pipecolic Acids / Q000627:therapeutic use*; D013449:Sulfonamides; D013921:Thrombocytopenia / Q000139:chemically induced*
D000925:Anticoagulants; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban