Correlation of urinary nitric oxide concentrations with the development of hip dysplasia in Labrador retrievers.
Urinary nitric oxide was determined in terms of the ratio of the concentrations of total urinary nitrite and nitrate:creatinine in 40 juvenile labrador retrievers, and radiographic signs of hip dysplasia and distraction indices were investigated in the same dogs in later life. The ratio was correlated significantly with the Norberg angle and with subchondral sclerosis in both hips, and with the grade of dysplasia in each hip and the dogs' overall grade of hip dysplasia. No correlations were observed between the ratio and the distraction indices or other radiographic criteria for hip dysplasia.
Division of Small Animal Surgery and Orthopedics, University of Bern, Länggass-Strasse 128, CH-3012 Bern, Switzerland.
K
K
Morich
S
S
Ohlerth
M
M
Reist
J
J
Lang
M
M
Riitano
P
P
Schawalder
D
D
Spreng
D000818:Animals; D015415:Biomarkers; D003404:Creatinine / Q000652:urine; D004285:Dogs; D005260:Female; D006619:Hip Dysplasia, Canine / Q000000981:diagnostic imaging* / Q000473:pathology / Q000652:urine*; D008297:Male; D009569:Nitric Oxide / Q000652:urine*; D010375:Pedigree; D011859:Radiography; D012720:Severity of Illness Index
D015415:Biomarkers; D009569:Nitric Oxide; D003404:Creatinine