Are gestational and essential hypertension similar? Left ventricular geometry and diastolic function.
OBJECTIVE
To evaluate the differences and similarities in diastolic function and left ventricular geometry in gestational and essential hypertension.


METHODS
Thirty-nine consecutive gestational hypertensive pregnant women in the third trimester of gestation (GH), 40 nonpregnant essential hypertensive women (EH), and 38 normotensive nonpregnant women (N) matched for age were enrolled into the study and underwent echocardiographic and Doppler evaluations. The GH and EH patients were evaluated prior to the administration of any drug treatment.


RESULTS
Left atrial function was similar in GH and N subjects and lower than that in EH patients. Both GH and EH patients had early left ventricular diastolic filling pattern significantly different as compared to N subjects (longer isovolumetric relaxation time, deceleration time of the E wave, and lower E wave velocity in GH and EH vs. N), whereas the late filling properties were similar in GH and N subjects with a lower A velocity, and velocity-time integral vs. EH (p < 0.05). Systolic fraction of the pulmonary vein flow was similar in GH and EH patients and lower in N subjects. Altered left ventricular geometry was more common in GH than in EH, whereas normotensive subjects did not show any alteration of the geometric pattern.


CONCLUSIONS
Gestational and essential hypertension induce similar early altered diastolic filling of the left ventricle. Essential hypertension is characterized by a compensatory late filling mechanism due to an enhancement of left atrial function. Gestational hypertension is characterized by altered left ventricular geometry, which is far less common during essential hypertension.
Novelli
Gian Paolo
GP
Semeiology and Medical Methodology, Tor Vergata University, Rome, Italy. bgp.novelli@tiscali.it
Valensise
Herbert
H
Vasapollo
Barbara
B
Larciprete
Giovanni
G
Di Pierro
Giuseppe
G
Altomare
Francesco
F
Arduini
Domenico
D
Galante
Alberto
A
D000328:Adult; D003971:Diastole / Q000502:physiology*; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011225:Pre-Eclampsia / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011247:Pregnancy; D016277:Ventricular Function, Left / Q000502:physiology*