[Severe felodipine and theophylline poisoning successfully treated by 4-aminopyridine: a case report].
The case of a 51-year-old man who ingested 100 mg of felodipine (Plendil, 20 tablets á 5 mg) and 9 g of theophylline (Theospirex retard, 30 tablets á 300 mg) is presented. The patient developed severe hypotension, tachycardia, circulatory insufficiency and paralytic ileus. No ECG effects were observed. Although felodipine led to a reduction in the bioability of theophylline, the serum theophylline concentration 15 h after the admission was 92 mg/L (the therapeutic concentration of theophylline 10-20 mg/L). The protracted hypotension did not respond to vasopressor and calcium therapy. The addition of 4-aminopyridine (4-AP) infusion resulted in fast receding of poisoning symptoms: increase of blood pressure, receding of circulatory insufficiency and metabolic acidosis, and return of peristalsis. This case suggests the usefulness of 4-AP in the treatment of poisoning by dihydropyridine derivatives. However, confirmation of the effectiveness of this substance for pharmacotherapy of dihydrophyridine derivatives poisoning requires further clinical research. The influence of 4-AP on calcium channels is indirect. It blocks potassium channels K1 in cytoplasm side which makes potassium stay inside the cell leading to depolarisation and opening of voltage-dependent calcium channels.
Magdalan
Jan
J
Katedra i Zakład Farmakologii Akademii Medycznej we Wrocławiu, 50-345 Wrocław, ul. Mikulicza-Radeckiego 2.
Kochman
Krystyna
K
Smolarek
Małgorzata
M
Przewłocki
Michal
M
Antończyk
Andrzej
A
D015761:4-Aminopyridine / Q000627:therapeutic use; D015736:Felodipine / Q000506:poisoning*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000175:diagnosis; D007418:Intestinal Pseudo-Obstruction / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D026902:Potassium Channel Blockers / Q000627:therapeutic use; D013406:Suicide, Attempted / Q000523:psychology*; D013610:Tachycardia / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy; D013806:Theophylline / Q000506:poisoning*; D014665:Vasodilator Agents / Q000506:poisoning*
D026902:Potassium Channel Blockers; D014665:Vasodilator Agents; D015761:4-Aminopyridine; D013806:Theophylline; D015736:Felodipine