Biological oxygen apparent transmissibility of hydrogel contact lenses with and without organosilicon moieties.
The instrument oxygen transmissibility (IOT) of organosilicon hydrogels, measured by electrochemical procedures, is 5-10 times larger than that of conventional hydrogels. A method is described that allows the estimation of the oxygen tension at the lens-cornea interface for closed- and open-eyelids situations by combining the IOT of the hydrogels and corneal parameters such as corneal thickness, corneal permeability and oxygen flux across the cornea. From these results the biological oxygen apparent transmissibility (BOAT) is obtained, an important parameter which an multiplication with the pressure of oxygen on the external part of the lens gives the oxygen flux onto the cornea. Contact lenses with oxygen transmissibility higher than 100 Dk/t units [1 Dk/t unit=10(-9) [cm(3) O(2) (STp) cm(-2)s(-1)(mmHg)(-1)] posses a large oxygen tension at the lens-cornea interface that substantially reduces the oxygen flux onto the cornea. Lenses whose oxygen transmissibility is lower than 50 Dk/t units allow a rather small oxygen flux onto the cornea under closed eyelids condition that prevent their use for extended wear.
Departamento de Termodinámica Aplicada, Universidad Politécnica de Valencia, 46020 Valencia, Spain. vicommo@ter.upv.es
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D003261:Contact Lenses; D003315:Cornea / Q000378:metabolism; D006801:Humans; D020100:Hydrogels / Q000378:metabolism*; D017646:Organosilicon Compounds / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D010313:Partial Pressure
D020100:Hydrogels; D017646:Organosilicon Compounds; D010100:Oxygen