Azidopeptide nucleic acid. An alternative strategy for solid-phase peptide nucleic acid (PNA) synthesis.
[reaction: see text] A practical and efficient method for PNA synthesis using an azide group to mask the N-terminus is reported. The deprotection was carried out in 5 min, while couplings were complete within 60 min. The near neutral conditions of the phosphine deprotection combined with the base-free coupling using hydroxybenzotriazole-activated monomers make this approach very mild.
Debaene
François
F
Institut de Science et Ingénierie Supramoleculaires, Université Louis Pasteur, 8 allée Gaspard Monge, 67000 Strasbourg, France.
Winssinger
Nicolas
N
D001386:Azides / Q000737:chemistry*; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis*
D001386:Azides; D020135:Peptide Nucleic Acids