Chiral tris(oxazoline)/Cu(II) catalyzed coupling of terminal alkynes and nitrones.
Novel chiral iPr-tris(oxazoline)/Cu(ClO4)2 x 6H2O catalyzed coupling of terminal acetylenes and nitrones to afford cis-disubstituted beta-lactams is described; the choice of base proves essential to both the diastereoselectivity and the enantioselectivity.
Ye
Meng-Chun
MC
Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Lu, Shanghai 200032, China.
Zhou
Jian
J
Huang
Zheng-Zheng
ZZ
Tang
Yong
Y
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007769:Lactams / Q000138:chemical synthesis; D009589:Nitrogen Oxides / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D010080:Oxazoles / Q000737:chemistry; D013237:Stereoisomerism
D000480:Alkynes; D007769:Lactams; D009589:Nitrogen Oxides; D009942:Organometallic Compounds; D010080:Oxazoles; C015388:nitrones; D003300:Copper