Expression of the endoplasmic reticulum chaperone GRP94 gene in ischemic gerbil brain.
GRP94 (glucose regulated protein 94) gene expression in the ischemic-hippocampus of gerbils, which was induced by a temporary occlusion of the bilateral common carotid arteries (CCAs), was tested by Northern blot analysis. The maximum GRP94 gene expression level was detected at the occipital lobe 10 min after the induction of ischemia. In the hippocampus, GRP94 gene expression reached a maximum 15 min after inducing ischemia. Following reperfusion, the maximum expression level was shown at 12 h and continuing thereafter.
Kim
Seung-Whan
SW
Department of Emergency Medicine, Chungnam National University Hospital, Taejon 301-721, Korea.
Park
Soojung
S
You
Kwan-Hee
KH
Kwon
O-Yu
OY
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000235:genetics; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D002546:Ischemic Attack, Transient / Q000235:genetics*; D007700:Kinetics; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D018832:Molecular Chaperones / Q000235:genetics; D015424:Reperfusion; D013997:Time Factors
D018840:HSP70 Heat-Shock Proteins; D008565:Membrane Proteins; D018832:Molecular Chaperones; C018551:glucose-regulated proteins