Chromosomal translocation in mesenchymal hamartoma of liver: what is its significance?
Mesenchymal hamartoma of the liver is generally considered to be benign in nature, and surgical excision has been the treatment of choice. There have been 3 reports on the association of cytogenetic abnormalities with this tumor, and the possibility of malignant potential has been raised. The authors report a fourth case with a previously unreported complex chromosomal translocation between chromosomes 11, 17, and 19 at bands q12, p11, and q13.3, respectively in all cells examined and discuss the significance of this finding.
Department of Surgical Paediatrics, Royal Hospital for Sick Children, Glasgow, Scotland, UK.
G V S
GV
Murthi
L
L
Paterson
A
A
Azmy
D006222:Hamartoma / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D008297:Male; D014178:Translocation, Genetic