[Severe mixed poisoning with diltiazem, potassium and magnesium: a case report].
We report the case of 52-year-old woman, who ingested 3.6 g of diltiazem, 16 g of potassium chloride and 6.5 g of magnesium, in a suicide attempt 4 hours before admission. She developed cardiorespiratory failure, with severe hypotonia and acute renal failure, in ECG third degree atrioventricular block was stated. The highest potassium concentration was 8.0 mmol/l, magnesium 2.15 mmol/l. As a result of multiple pharmacologic intervention, including intravenous fluids, calcium, glucagon, dopamine, dobutamine, norepinephrine, transvenous pacing and peritoneal dialysis (haemodynamic instability makes haemodialysis noneffective) the haemodynamic stabilization of cardiovascular system and normalization of potassium and magnesium concentration were achieved. The diltiazem concentration was measured using liquid chromatography, the result was 0.89 microgram/ml. She was discharged in a good clinical condition on day 26th.
Klinika Toksykologii Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie, 31-826 Kraków, Os. Złotej Jesieni 1.
Dorota
D
Szpak
Barbara
B
Groszek
Wiesław
W
Piotrowski
Mariusz
M
Scisłowski
D000959:Antihypertensive Agents / Q000506:poisoning*; D004110:Diltiazem / Q000506:poisoning*; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008274:Magnesium / Q000506:poisoning*; D008875:Middle Aged; D011188:Potassium / Q000506:poisoning*; D012720:Severity of Illness Index; D013406:Suicide, Attempted / Q000523:psychology*
D000959:Antihypertensive Agents; D004110:Diltiazem; D008274:Magnesium; D011188:Potassium