Sequence analysis of two de novo mutation alleles at the DXS10011 locus.
We have detected two unusual alleles at the DXS10011 locus in two paternity trio cases. In one case, one allele of the daughter was found not to have been derived from the mother but the other allele was shared with the father. In the other case, the mother and the son shared no bands. Paternity in both cases was established using conventional polymorphic markers in addition to DNA markers (probabilities: >0.999999). Sequencing showed that the two de novo alleles of the children acquired a single unit (GAAA).
Tamura
Akiyoshi
A
Department of Legal Medicine, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan. leg003@art.osaka-med.ac.jp
Iwata
Misa
M
Takase
Izumi
I
Miyazaki
Tokiko
T
Matsui
Kiyoshi
K
Nishio
Hajime
H
Suzuki
Koichi
K
D000483:Alleles; D041321:Chromosomes, Human, X; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D009154:Mutation; D010334:Paternity; D017422:Sequence Analysis, DNA; D020080:Tandem Repeat Sequences
D005819:Genetic Markers