Use of ketorolac tromethamine in children undergoing scoliosis surgery. an analysis of complications.
BACKGROUND
Ketorolac Tromethamine (ketorolac) is a nonsteroidal anti-inflammatory drug (NSAID) with proven efficacy in decreasing postoperative pain in various surgical settings, including the treatment of spine deformities. However, some studies have raised questions regarding the potential side effects of this agent, such as increased bleeding and inhibition of bony fusion.


OBJECTIVE
This study was conducted to determine whether there is any association between the use of ketorolac and postoperative complications in a group of children who underwent scoliosis surgery.


METHODS
This is a retrospective review of a group of children who underwent spinal fusion between 1989 to 1999 at our institution.


METHODS
Data on a total of 208 children were analyzed in this study. Sixty received ketorolac and 148 did not.


METHODS
Postoperative transfusion and reoperation rates were the two main outcome measures of interest.


METHODS
A retrospective review of 208 children who underwent scoliosis surgery was conducted, with a focus on ketorolac use. Univariate analysis and logistic regression were used to quantify the determinants of postoperative complications.


RESULTS
Our analyses detected no significant differences in a broad range of socioclinical variables between the two patient groups, including age at surgery, gender, type of scoliosis, surgical approach, use of erythropoietin, levels of curvature and degree of curvature. Analysis of complication rates focusing on postoperative transfusion and revision surgery showed that there were no significant differences between the two groups.


CONCLUSIONS
In this retrospective study of 208 children undergoing spine surgery, postoperative use of ketorolac did not significantly increase complications, including transfusion and reoperation.
Vitale
Michael G
MG
International Center for Health Outcomes and Innovative Research, College of Physicians and Surgeons, and the Josepth L. Mailman School of Public Health, Columbia University and New York Presbyterian Hospital, New York, NY 10032, USA. mgv16@yahoo.com
Choe
Julie C
JC
Hwang
Matthew W
MW
Bauer
Rebecca M
RM
Hyman
Joshua E
JE
Lee
Francis Y
FY
Roye
David P
DP
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001803:Blood Transfusion; D002648:Child; D005260:Female; D006801:Humans; D020911:Ketorolac Tromethamine / Q000009:adverse effects*; D008297:Male; D015999:Multivariate Analysis; D012086:Reoperation; D012189:Retrospective Studies; D012600:Scoliosis / Q000601:surgery*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D020911:Ketorolac Tromethamine