Vaccination against Fowlpox virus via drinking water.
The oral vaccination against Fowlpox was investigated via drinking water containing the F132-c strain of Fowlpox virus to be effective even though the vaccine virus-titer was 10(4) TCID (50)/dose each time. When the virus-titer of the F132-c strain was 10(4-5 )TCID(50)/dose per single drinking water vaccination, 90% or more of chickens were not protected, however, they were protected when vaccinated twice via drinking water. A weak immune response occurred by a slight infection after the first vaccination, and due to memory cells, a booster could work well after the second vaccination. These results suggest the possibility of reducing both the amount of virus required for a vaccine via drinking water and the labor cost in the field.
The Chemo-Sero-Therapeutic Research Institute, Okuba, Kumamoto, Japan.
Rikako
R
Ariyoshi
Kozo
K
Takase
Yuichi
Y
Matsuura
Kazuhiro
K
Deguchi
Akihiro
A
Ginnaga
Hideo
H
Fujikawa
D000818:Animals; D002645:Chickens; D005586:Fowlpox / Q000276:immunology*; D005587:Fowlpox virus / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D014881:Water Supply
D014765:Viral Vaccines