Alpha-pyrones and a 2(5H)-furanone from Hyptis pectinata.
Three pyrones and a 2(5H)-furanone, designated pectinolides D-G, have been isolated from the dichloromethane extract of Hyptis pectinata. The metabolites were characterized on the basis of 1D and 2D NMR spectroscopic techniques. The pyrones were identified as 6S-[3S,6S-(diacetoxy)-5R-hydroxy-1Z-heptenyl]-5S-hydroxy-5,6-dihydro-2H-pyran-2-one (1)- pectinolide D, 6S-[3S,5R,6S-(triacetoxy)-1Z-heptenyl]-5S-acetoxy-5,6-dihydro-2H-pyran-2-one (2)- pectinolide E and 6S-[3S,5R,6S-(triacetoxy)-1Z-heptenyl]-5S-acetoxy-4R-methoxy-3,4,5,6-tetrahydro-4H pyran-2-one (3)- pectinolide F. The furanone was identified as [2'Z,5(1')Z] 5-(4'S,6'R,7'S-triacetoxy-2-octenylidene)-2(5H)-furanone (4)-pectinolide G.
Department of Biological and Chemical Sciences, University of the West Indies, Cave Hill Campus, PO Box 64, Bridgetown, Barbados.
Dionne M
DM
Boalino
Joseph D
JD
Connolly
Stewart
S
McLean
William F
WF
Reynolds
Winston F
WF
Tinto
D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification; D031331:Hyptis / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification; D013237:Stereoisomerism
D005663:Furans; D011753:Pyrones