[Changes in adrenergic and cholinergic innervation of the external genitalia in alcohol and drug intoxication].
Eighteen cadavers of persons, who died of acute and chronic alcohol and drug intoxication (ephedron-addiction), were used to study the changes in the spinal nerve plexuses and external genitals. The activity of acetylcholinesterase and of NADPH-diaphorase was determined histochemically; the adrenergic nerve fibers were detected by a glyoxyl-acid technique. Rectified changes in the relative density of adrenal-cholinergic- and nitroxydergic structures and in the activity of mediators in different intoxications were found. The chronic intoxication by alcohol and ephedron was accompanied by a reduced activity of enzymes involved in the metabolism of acetylcholine, nitric oxide and catecholamines. A lower density was observed in the nerve fibers that contained the examined substances. The results can be used as an additional criterion in evaluating the male sexual-function status.
Pigolkin
Iu I
IuI
Sherstiuk
B V
BV
Dmitrieva
O A
OA
D000293:Adolescent; D000320:Adrenergic Fibers / Q000201:enzymology / Q000473:pathology*; D000328:Adult; D000435:Alcoholic Intoxication / Q000503:physiopathology; D000437:Alcoholism / Q000503:physiopathology; D002102:Cadaver; D002799:Cholinergic Fibers / Q000201:enzymology / Q000473:pathology*; D005260:Female; D005835:Genitalia / Q000294:innervation* / Q000473:pathology; D006801:Humans; D008297:Male; D009252:NADPH Dehydrogenase / Q000378:metabolism; D019966:Substance-Related Disorders / Q000503:physiopathology*
D009252:NADPH Dehydrogenase