At the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulation.
The tumor suppressor kinase LKB1 has been identified as a physiologic activator of the key metabolic regulator 5'-AMP-activated protein kinase, establishing a possible molecular link between the regulation of metabolism and cell proliferation.
Kyriakis
John M
JM
Molecular Cardiology Research Institute, Tufts-New England Medical Center, 750 Washington Street, Boston, MA 02111, USA. jkyriakis@tufts-nemc.org
D000091162:AMP-Activated Protein Kinase Kinases; D055372:AMP-Activated Protein Kinases; D000818:Animals; D048708:Cell Growth Processes / Q000502:physiology*; D049109:Cell Proliferation; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans; D009097:Multienzyme Complexes / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*
D009097:Multienzyme Complexes; D017346:Protein Serine-Threonine Kinases; C109790:STK11 protein, human; D000091162:AMP-Activated Protein Kinase Kinases; D055372:AMP-Activated Protein Kinases