[The problem of assessment of efficacy of antihypertensive therapy using 24-hour blood pressure monitoring].
Main advantages of the use of 24-hour blood pressure (BP) monitoring for assessment of effects of antihypertensive therapy consist in more precise selection of patients requiring drug treatment and more objective evaluation of results of therapy. However methodological limitations also exist. Among them are susceptibility of results to regression to the mean, insufficient understanding of many characteristics of 24-hour BP profile, interdependence (co-linearity) of various parameters. Lack of convincing data on prognosis of patients whose antihypertensive treatment has been guided by 24-hour BP monitoring also presents a serious problem. Promising direction of further research is investigation of reproducibility and reliability of different parameters of BP monitoring in relatively short-term studies including those with surrogate end points.
Research Center for Preventive Medicine, Petroverigsky per. 10, 101953 Moscow, Russia.
V M
VM
Gorbunov
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001795:Blood Pressure Determination; D015924:Blood Pressure Monitors; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000188:drug therapy*; D018579:Patient Selection
D000959:Antihypertensive Agents