A mild and efficient one-step synthesis of quinolines.
[reaction: see text] The Friedländer synthesis of quinolines is an extensively employed protocol, yielding the desired heterocycle in a two-step reduction-condensation sequence. We have developed a mild, efficient, high-yielding single-step variant of this methodology, which employs SnCl(2) and ZnCl(2) to effect the reaction.
McNaughton
Brian R
BR
Department of Dermatology, The Center for Future Health, University of Rochester, Rochester, New York 14642, USA.
Miller
Benjamin L
BL