Preexisting crescentic glomerulonephritis in the renal allograft.
Two patients who received cadaveric renal transplants from the same donor were found to have similar diffuse proliferative glomerular lesions on renal biopsies performed for delayed graft function. The donor had no known disease, but had subtle abnormalities on preprocurement urinalysis. In retrospect, lupus nephritis is suspected in the donor. The authors detail the course of these 2 patients, review the literature on preexisting glomerular lesions, and address issues with regard to donor selection.
Kiser
Raymond L
RL
Department of Nephrology,, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7155, USA.
Thomas
David B
DB
Andreoni
Kenneth
K
Klemmer
Philip J
PJ
D000328:Adult; D001706:Biopsy; D003404:Creatinine / Q000097:blood; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008181:Lupus Nephritis; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D003404:Creatinine