Volumetric diffuse optical tomography of brain activity.
We present three-dimensional diffuse optical tomography of the hemodynamic response to somatosensory stimulation in a rat. These images show the feasibility of volumetrically imaging the functional response to brain activity with diffuse light. A combination of positional optode calibration and contrast-to-noise ratio weighting was found to improve imaging performance.
Culver
Joseph P
JP
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. jculver@nmr.mgh.harvard.edu
Siegel
Andrew M
AM
Stott
Jonathan J
JJ
Boas
David A
DA
D000465:Algorithms; D000818:Animals; D001921:Brain / Q000502:physiology*; D003198:Computer Simulation; D005240:Feasibility Studies; D005552:Forelimb / Q000502:physiology; D007091:Image Processing, Computer-Assisted; D008027:Light; D008962:Models, Theoretical; D051381:Rats; D012542:Scattering, Radiation; D041623:Tomography, Optical Coherence