Unilateral uveitis induced by a nonionic iodinated contrast agent.
OBJECTIVE
To report recurrent unilateral uveitis after computed tomography (CT) enhanced by the contrast agent iopamidol.


METHODS
Observational case report.


METHODS
A 44-year-old man with a history of mixed-cellularity Hodgkin lymphoma, Stage I B (axillar, infraclavicular, subpectoral lymphomas) was under remission after chemotherapy and radiotherapy. The contrast-enhanced CT scans performed every 3 months were within hours followed by a marked unilateral anterior uveitis, vitritis, and retinal bleedings. Symptoms resolved with topical corticosteroid treatment within a week.


RESULTS
We observed recurrent unilateral uveitis after intravenously application of 150 ml of iopamidol for contrast-enhanced CT scans in a patient with lymphoma in remission.


CONCLUSIONS
Iopamidol may induce uveitis under certain circumstances. We suggest a coincidence of immunologic mechanisms with predisposing discrete vascular radiation damage.
Departments of Ophthalmology, City Hospital Triemli, Zurich, Switzerland. eveline.welzl@triemli.stzh.ch
Eveline
E
Welzl-Hinterkörner
Mark
M
Haefner
Bernard
B
Mengiardi
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003287:Contrast Media / Q000009:adverse effects*; D005128:Eye Diseases / Q000139:chemically induced / Q000188:drug therapy; D006689:Hodgkin Disease / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D007479:Iopamidol / Q000009:adverse effects*; D008297:Male; D012074:Remission Induction; D012166:Retinal Hemorrhage / Q000139:chemically induced / Q000188:drug therapy; D014057:Tomography, X-Ray Computed; D014606:Uveitis, Anterior / Q000139:chemically induced* / Q000188:drug therapy; D014822:Vitreous Body / Q000187:drug effects
D003287:Contrast Media; D007479:Iopamidol