[Effect of kangxin capsule on homocysteine and beta-amyloid protein in vascular dementia patients].
OBJECTIVE
To observe the effect of Kangxin capsule (KXC) on homocysteine (HCY) and beta-amyloid protein (beta-Ap) in patients with vascular dementia.


METHODS
Sixty-three patients with vascular dementia were randomly divided into two groups, the 33 patients in the treated group and the 30 in the control group. Basal treatment were given to both groups, besides, KXC was given to the treated group and Hydergine was given to the control group. The levels of plasma HCY, beta-Ap as well as the changes of mini mental state examination (MMSE), activity of daily living (ADL) and TCM Syndrome scoring were observed before and after treatment.


RESULTS
KXC could significantly decrease the levels of HCY and beta-Ap (P < 0.01), rise the MMSE scores, reduce ADL scores and ameliorate TCM Syndrome.


CONCLUSIONS
KXC can effectively regulate the levels of HCY, beta-Ap in vascular dementia patients.
Fujian TCM College, Fuzhou 350003. caijl@163.com
Jing
J
Cai
Jian
J
Du
Jun-shan
JS
Huang
D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000097:blood*; D002214:Capsules; D015140:Dementia, Vascular / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D008517:Phytotherapy
D016229:Amyloid beta-Peptides; D002214:Capsules; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D006710:Homocysteine; D009569:Nitric Oxide