[Activity of Ca(2+)-dependent neutral proteinases in rat organs under cobalt and mercury chloride injection].
The activity of Ca(2+)-dependent neutral proteinases in rats under cobalt and mercury chloride injection was investigated. The calpains activity increase in the lungs, heart, liver and kidneys was revealed after 2 h cobalt chloride action. The mercury chloride gives a reliable increase of calcium-dependent neutral proteinases only in the kidneys.
Karazin Kharkov National University, Institute of Therapy, AMS of Ukraine, Kharkov. Pavel.A.Kaliman@univer.kharkov.ua
P A
PA
Kaliman
A A
AA
Samokhin
L M
LM
Samokhina
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002154:Calpain / Q000378:metabolism; D003035:Cobalt / Q000008:administration & dosage / Q000494:pharmacology*; D010450:Endopeptidases / Q000187:drug effects* / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008627:Mercuric Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D003035:Cobalt; D008627:Mercuric Chloride; D010450:Endopeptidases; D002154:Calpain; D002118:Calcium