Inherited vitamin K deficiency: case report and review of literature.
Vitamin K is the cofactor for the hepatic carboxylation of glutamic acid residues in a number of proteins including the procoagulants factors II, VII, IX, and X. The role of vitamin K in normal bone function is not fully understood. Inherited deficiency of vitamin K dependent coagulation factors is a rare bleeding disorder reported only in a few patients. Here we present an 18-month old child who presented with osteopeni due to inherited vitamin K deficiency. While the patient had high bone specific alkaline phosphatase and parathyroid hormone levels and low osteocalcin and bone mineral density values, with the regular supplementation of vitamin K all the mentioned parameters returned to normal values.
Orbak
Zerrin
Z
Department of Pediatric Endocrinolgoy, Atatürk University Faculty of Medicine, Erzurum, Turkey. zerrinorbak@yahoo.com
Selimoglu
Ayse
A
Doneray
Hakan
H
D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000209:etiology; D006801:Humans; D007223:Infant; D008297:Male; D015675:Osteocalcin / Q000097:blood; D011517:Prothrombin Time; D014813:Vitamin K Deficiency / Q000097:blood / Q000150:complications / Q000235:genetics*
D015675:Osteocalcin