[A quantitative evaluation of blood-lymphocyte subpopulation in herpetic ocular disease].
Data on changing contents of blood-lymphocytes' subpopulations in patients with ophthalmoherpes are reported. A higher number of blood cells expressing the surface activation antigens of HLA-DR+, CD71+ and CD95+, a lower number of T-helpers and a reduced value of the immune-regulating index were found to be typical of such changes. A more significant increase in the quantity of CD95+ lymphocytes, as observed in cases of severe ophthalmoherpes versus its moderate clinical course, could be a prognostication criterion. The essential shifts occurring in the T-cells' population denote the status of tension in the immune response provoked by an intensified reproduction of herpes simplex virus (HSV); at the same time, they are indicative of a certain deficit in the immune-protection mechanisms.
Mal'khanov
V B
VB
Shevchuk
N E
NE
Marvanova
Z R
ZR
D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D005128:Eye Diseases / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006684:HLA-DR Antigens / Q000032:analysis; D006561:Herpes Simplex / Q000097:blood / Q000175:diagnosis / Q000276:immunology*; D006801:Humans; D016131:Lymphocyte Subsets / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011990:Receptors, Transferrin; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D019014:fas Receptor / Q000032:analysis
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D015415:Biomarkers; C068126:CD71 antigen; D006684:HLA-DR Antigens; D011990:Receptors, Transferrin; D019014:fas Receptor