No evidence for involvement of IL-4R and CD11B from the IBD1 region and STAT6 in the IBD2 region in Crohn's disease.
Linkage studies have identified the inflammatory bowel disease (IBD)1 locus on chromosome 16 and the IBD2 locus on chromosome 12 to be involved in Crohn's disease. NOD2/CARD15 was identified as the gene of interest within the IBD1 region. However, linkage to this region could not be explained by NOD2/CARD15 alone. Here we set out to assess the association of additional candidate genes from the IBD1 and IBD2 loci with Crohn's disease using transmission disequilibrium testing in patient-parent triads. No significant association was observed with genetic variants in the genes coding for interleukin-4 receptor gene (IL-4R), CD11B and signal transducer and activator of transcription type 6 (STAT6). Results for IL-4R were not affected by exclusion of all families carrying one of three risk alleles in NOD2. From this we conclude that IL-4R and CD11B in the IBD1 region and STAT6 in the IBD2 region are not involved in Crohn's disease in this Dutch cohort.
Department of Gastroenterology & Hepatology, University Medical Center Nijmegen, The Netherlands. d.dejong@mdl.umcn.nl
Dirk J
DJ
de Jong
Barbara
B
Franke
Anton H J
AH
Naber
Judith J H T
JJ
Willemen
Angelien J G A M
AJ
Heister
Han G
HG
Brunner
Carolien G F
CG
de Kovel
Frans A
FA
Hol
D000328:Adult; D039481:CD11b Antigen / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12; D002885:Chromosomes, Human, Pair 16; D015331:Cohort Studies; D003424:Crohn Disease / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D019948:Receptors, Interleukin-4 / Q000235:genetics*; D050800:STAT6 Transcription Factor; D015534:Trans-Activators / Q000235:genetics*
D039481:CD11b Antigen; D019948:Receptors, Interleukin-4; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human; D015534:Trans-Activators