Dermal endothelial cells express eotaxin in hypereosinophilic syndrome.
We describe a patient with hypereosinophilic syndrome, who had severe cutaneous eruptions. Immunohistochemical study revealed that dermal endothelial cells in the lesional skin of this patient expressed eotaxin, which indicates eotaxin plays a part in inducing eosinophil migration into cutaneous tissue in hypereosinophilic syndrome.
Department of Dermatology, University of Tokyo, Hongo, Japan. ytsun-tky@umin.ac.jp
Yuichiro
Y
Tsunemi
Takeo
T
Idezuki
Koichiro
K
Nakamura
Kunihiko
K
Tamaki
D000368:Aged; D054413:Chemokine CCL11; D019742:Chemokines, CC / Q000096:biosynthesis*; D004727:Endothelium / Q000166:cytology / Q000378:metabolism; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000378:metabolism* / Q000473:pathology
C515456:CCL11 protein, human; D054413:Chemokine CCL11; D019742:Chemokines, CC