Interrupter resistance and wheezing phenotypes at 4 years of age.
It is difficult to distinguish young children with respiratory symptoms who will develop asthma from those with transient symptoms only. Measurement of interrupter resistance may help to identify children at high risk of asthma. The aim of this study is to compare interrupter resistance in 4-year-old children with different wheezing phenotypes. All children participated in the Prevention and Incidence of Asthma and Mite Allergy cohort, a prospective birth cohort of more than 4,000 children. At 4 years of age, data on interrupter resistance plus wheezing phenotype were available for 838 children. Mean interrupter resistance values (95% confidence interval) were 0.95 (0.93, 0.97), 0.95 (0.92, 0.98), 0.96 (0.87, 1.05), and 1.08 (1.02, 1.14) kPa.L(-1).second for never (n = 482), early transient (n = 236), late-onset (n = 22), and persistent (n = 98) wheezing phenotypes, respectively. Additional analyses were performed for children with atopic and nonatopic mothers separately. Both in children with atopic and nonatopic mothers, children with persistent wheeze had significantly higher interrupter resistance values than children with never and early wheeze. In conclusion, mean interrupter resistance values were higher in children with persistent wheeze as compared with children with never and early transient wheezing phenotypes.
Brussee
Jessica E
JE
Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Smit
Henriëtte A
HA
Koopman
Laurens P
LP
Wijga
Alet H
AH
Kerkhof
Marjan
M
Corver
Karen
K
Vos
Ada P H
AP
Gerritsen
Jorrit
J
Grobbee
Diederick E
DE
Brunekreef
Bert
B
Merkus
Peter J F M
PJ
de Jongste
Johan C
JC
D000403:Airway Resistance; D001249:Asthma / Q000175:diagnosis*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D012129:Respiratory Function Tests; D012135:Respiratory Sounds / Q000503:physiopathology*; D012307:Risk Factors