Cell cycle control, DNA damage checkpoints and cancer.
DNA damage checkpoints are essential control points in the cell cycle ensuring effective damage repair. The loss of checkpoint functions leads to loss of genomic integrity and allows accumulation of genetic damage in the daughter cells. Checkpoint deficiency is one of the main causes of DNA aberrations in cancer.
Laiho
Marikki
M
Haartman Institute, Molecular Cancer Biology Research Program, University of Helsinki and Helsinki University Central Hospital, FIN-00014 Helsinki, Finland. Marikki.Laiho@Helsinki.Fi
Latonen
Leena
L
D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins / Q000378:metabolism; D004249:DNA Damage; D004261:DNA Replication; D016158:Genes, p53; D006801:Humans; D008938:Mitosis; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism*
C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins