HT and breast cancer risk.
Two large recent studies indicate an increased risk of breast cancer with use of menopausal hormone therapy (HT), particularly combinations of estrogen and progestogen. These studies also go against previous theories of the types of breast cancer that would be associated with HT use. Emerging information regarding the influence of estrogen plus progestin on breast cancer risk adds further weight to the recommendation against use for chronic disease risk reduction and raises additional questions regarding risks of even short-term use for vasomotor symptoms associated with menopause.
Geller
Michelle L
ML
Harbor-UCLA Research and Education Institute, Torrance, CA 90502, USA. rchlebow@whi.org
Chlebowski
Rowan T
RT
D001943:Breast Neoplasms / Q000139:chemically induced / Q000453:epidemiology; D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D005260:Female; D006801:Humans; D008593:Menopause; D011372:Progestins; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D016387:Women's Health
D011372:Progestins