[Evaluation of QOL with orally disintegrating antiemetic tablets in outpatient chemotherapy].
An investigation into the effect of orally disintegrating antiemetic tablets (ramosetron OD 0.1 mg) on 16 outpatients undergoing chemotherapy for recurrent gynecologic malignancies was carried out using a questionnaire to evaluate their quality of life (QOL). The patients were divided into 2 groups: a control group in which the patients received only an intravenous drip infusion of 0.3 mg of ramosetron on the day of their chemotherapy and a double antiemetic therapy group in which the patients were treated with orally disintegrating antiemetic tablets for 4 days in addition to the intravenous drip. When outpatient chemotherapy (paclitaxel 80 mg/m2/1 h div + CBDCA AUC 2/1 h div) was performed, a comparison was made between the 2 groups, based on the results of a QOL questionnaire for antiemetic therapy during cancer chemotherapy (Ishihara's QOL survey method). This study found a greater improvement in QOL in the double antiemetic therapy group on days 2 to 4, a period when deterioration in QOL is usually observed. These findings suggest that orally disintegrating antiemetic tablets as a measure to reduce delayed nausea and vomiting are useful for improving QOL.
Second Dept. of Obstetrics and Gynecology, School of Medicine, Toho University.
Fumitoshi
F
Terauchi
Takeo
T
Nagashima
Satoko
S
Iwaki
Yukari
Y
Kobayashi
Yoshiharu
Y
Kanemura
Yasuhiro
Y
Yamamoto
Tetsuya
T
Moritake
Takayuki
T
Seiki
Hisao
H
Ogura
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000008:administration & dosage*; D016190:Carboplatin / Q000008:administration & dosage; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008875:Middle Aged; D010045:Outpatients; D017239:Paclitaxel / Q000008:administration & dosage; D011788:Quality of Life; D011795:Surveys and Questionnaires; D013607:Tablets
D000932:Antiemetics; D001562:Benzimidazoles; D013607:Tablets; C071315:ramosetron; D016190:Carboplatin; D017239:Paclitaxel