A whole genome association study in Icelandic multiple sclerosis patients with 4804 markers.
Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system (CNS) with a complex genetic background. Here we use a genome-wide association strategy with 4804 microsatellite markers successfully typed in separately pooled DNA from 200 patients and 200 controls. A total of 91 markers showed evidence of association. When compared to our in-house physical map of the genome, six 2-Mb regions containing at least two of these markers were detected. Of those, three regions have one or more markers among the 20 most strongly associated: chromosomes 3q25, 6p21.3 (the MHC region) and 19q13.
Jonasdottir
Aslaug
A
deCODE Genetics, Sturlugata 8, IS-101 Reykjavik, Iceland. aslaug.jonasdottir@decode.is
Thorlacius
Theodora
T
Fossdal
Ragnheidur
R
Jonasdottir
Adalbjorg
A
Benediktsson
Kjartan
K
Benedikz
John
J
Jonsson
Hjortur H
HH
Sainz
Jesus
J
Einarsdottir
Helga
H
Sigurdardottir
Sonja
S
Kristjansdottir
Gudlaug
G
Sawcer
Stephen
S
Compston
Alastair
A
Stefansson
Kari
K
Gulcher
Jeffrey
J
D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods* / Q000706:statistics & numerical data; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D007391:International Cooperation; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*