Differences in host susceptibility to disease progression in the human challenge model of Haemophilus ducreyi infection.
With human volunteers inoculated at two sites with Haemophilus ducreyi, outcomes for a subject were not independent. In a reinfection trial, 2 of 11 previous pustule formers and 6 of 10 previous resolvers resolved all sites of infection. There was no correlation between serum bactericidal or phagocytic activity and outcome in the trial. These data indicate that different hosts are differentially susceptible to disease progression versus resolution in the model.
Departments of Medicine, Indiana University, Indianapolis, Indiana 46202, USA. sspinola@iupui.edu
Stanley M
SM
Spinola
Cliffton T H
CT
Bong
Andrew L
AL
Faber
Kate R
KR
Fortney
Stacy L
SL
Bennett
Carisa A
CA
Townsend
Beth E
BE
Zwickl
Steven D
SD
Billings
Tricia L
TL
Humphreys
Margaret E
ME
Bauer
Barry P
BP
Katz
D000328:Adult; D001770:Blood Bactericidal Activity; D018450:Disease Progression; D004198:Disease Susceptibility; D005260:Female; D006192:Haemophilus Infections / Q000276:immunology*; D006191:Haemophilus ducreyi; D006801:Humans; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis; D012189:Retrospective Studies; D013492:Suppuration / Q000276:immunology