[Nitric oxide production in pregnancy and experimental acute kidney insufficiency].
Nitric oxide production in organs of pregnant mice (liver, kidney, placenta) was measured using specifical NO traps, Fe-dithiocarbamate complexes (Fe-DETC) forming with NO paramagnetic mononitrosyl iron complexes with DETC (MNIC-DETC), detected by EPR method (-196 degrees C). The amount of NO formed increased in dependence of the pregnancy period (from the first to the third trimesters). Addition of NO-synthase substrate, L-arginine, insignificantly influenced endogenous NO production. However, endogenous NO amount sharply decreased at experimental acute renal failure.
Burgova
E N
EN
Semenov Institute of Chemical Physics RAS, Kosygin str., 4 Moscow, 119991 Russia.
Murashko
A V
AV
Murashko
L E
LE
Serezhenkov
V A
VA
Vanin
A F
AF
D058186:Acute Kidney Injury / Q000378:metabolism*; D000818:Animals; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000096:biosynthesis*; D009928:Organ Specificity; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000378:metabolism*
D009569:Nitric Oxide