[The effects of intranasal FP on the expression of aquaporin-2 in nasal polyps].
OBJECTIVE
To study the effects of intranasal FP on the expression of AQP-2 in nasal polyps.


METHODS
Fourteen cases of type II phase 3 and 12 cases of type III nasal polyps were selected. FP were intranasally used in 7 cases of type II phase 3 and 6 cases of type III nasal polyps for 7 days before operation. The others, treated with nothing, were used as control. 26 nasal polyps were obtained and studied with immunohistochemical technique.


RESULTS
The volume of nasal polyps in FP-using group became smaller. Both the number of AQP-2 positive cells and the area density were significantly lower in the FP-using group than in the control group (P < 0.01).


CONCLUSIONS
Under the action of intranasal FP the expression of AQP-2 reduced, so is the volume of nasal polyps. It indicated that AQP-2 contributed to edema of nasal polyps and FP may lesson edema through changing the expression of AQP-2.
Department of Otorhinolaryngology, Third Hospital of Hebei Medical University, Shijiazhuang 050051.
Xun
X
Zhang
Yongyi
Y
Yuan
Wenping
W
Gu
Junshang
J
Mu
Yan
Y
Qu
D000281:Administration, Intranasal; D000328:Adult; D000368:Aged; D000730:Androstadienes / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D051399:Aquaporin 2; D020346:Aquaporins / Q000096:biosynthesis*; D005260:Female; D000068298:Fluticasone; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism / Q000473:pathology*
C496023:AQP2 protein, human; D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D051399:Aquaporin 2; D020346:Aquaporins; D000068298:Fluticasone