Monocyte chemotactic protein-1 in cervical and amniotic fluid: relationship to microbial invasion of the amniotic cavity, intra-amniotic inflammation, and preterm delivery.
OBJECTIVE
The purpose of this study was to evaluate the role of monocyte chemotactic protein-1 in cervical and amniotic fluid in women in preterm labor and with preterm premature rupture of membranes.


METHODS
Women with singleton pregnancies (<or=34 weeks) in preterm labor (n=75 women), with preterm premature rupture of membranes (n=47 women), and at term (n=45 women) who were undergoing elective cesarean delivery were included. Cervical and amniotic fluid were sampled.


RESULTS
Monocyte chemotactic protein-1 in cervical and amniotic fluid was higher in women in preterm labor than in women at term. Cervical monocyte chemotactic protein-1 in women in preterm labor was associated with microbial invasion of the amniotic cavity, intra-amniotic inflammation, delivery within 7 days, and at <or=34 weeks. Amniotic monocyte chemotactic protein-1 correlated to microbial invasion of the amniotic cavity in women with preterm premature rupture of membranes, intra-amniotic inflammation in preterm labor, preterm premature rupture of membranes, delivery within 7 days, and delivery at <or=34 weeks in women in preterm labor.


CONCLUSIONS
Monocyte chemotactic protein-1 in cervical and amniotic fluid levels are elevated in preterm labor and preterm premature rupture of membranes and correlate to intra-amniotic infection/inflammation.
Department of Obstetrics and Gynecology, Perinatal Center, Institute for the Health of Women and Children, Göteborg, Sweden. bo.jacobsson@obgyn.gu.se
Bo
B
Jacobsson
Rose-Marie
RM
Holst
Ulla-Britt
UB
Wennerholm
Bengt
B
Andersson
Håkan
H
Lilja
Henrik
H
Hagberg
D000653:Amniotic Fluid / Q000737:chemistry*; D015415:Biomarkers / Q000032:analysis; D001826:Body Fluids / Q000737:chemistry; D002584:Cervix Uteri; D018932:Chemokine CCL2 / Q000032:analysis*; D002821:Chorioamnionitis / Q000378:metabolism*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000378:metabolism*; D006801:Humans; D007752:Obstetric Labor, Premature / Q000378:metabolism*; D011247:Pregnancy; D011446:Prospective Studies
D015415:Biomarkers; D018932:Chemokine CCL2