Human Alu element retrotransposition induced by genotoxic stress.
Alu elements are found exclusively in primate species and comprise over 10% of the human genome. To better define the mechanisms responsible for Alu replication, we introduced a human Alu element into mouse cells. We report that Alu retrotransposition can be induced in mouse cells by exposure to the topoisomerase II inhibitor etoposide and is mediated in trans by endogenous mouse long interspersed elements (LINEs).
Hagan
Christy R
CR
Biological Sciences Division and Committee on Cancer Biology, University of Chicago, Chicago, Illinois 60637, USA.
Sheffield
Rebecca F
RF
Rudin
Charles M
CM
D020087:Alu Elements; D000818:Animals; D006801:Humans; D020084:Long Interspersed Nucleotide Elements; D051379:Mice; D009153:Mutagens / Q000633:toxicity*; D059005:Topoisomerase II Inhibitors
D009153:Mutagens; D059005:Topoisomerase II Inhibitors