Interaction of Ginkgo biloba extract (GBE) with hypotensive agent, nicardipine, in rats.
The effect of Ginkgo biloba extract (GBE, 0.5%) orally administered for 2 weeks on the antihypertensive action of oral nicardipine was examined in Wistar rats. GBE significantly increased hepatic P-450 content and reduced the hypotensive effect of nicardipine. GBE administration resulted in a significant decrease in maximal nicardipine plasma concentration (Cmax) and the 23-hour area under the curve (AUC0-23). Thus, it is suggested that GBE attenuated the therapeutic potency of nicardipine, probably secondary to increased hepatic drug metabolism.
Kubota
Yoko
Y
Department of Pharmacology, School of Pharmaceutical Sciences, Research Institute for Biosciences, Mukogawa Women's University, Nishinomiya 663-8179, Japan.
Kobayashi
Kyoko
K
Tanaka
Naoka
N
Nakamura
Kazuki
K
Kunitomo
Masaru
M
Umegaki
Keizo
K
Shinozuka
Kazumasa
K
D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D019540:Area Under Curve; D001219:Aspartate Aminotransferases / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004032:Diet; D004336:Drug Antagonism; D004347:Drug Interactions; D020441:Ginkgo biloba / Q000737:chemistry; D006339:Heart Rate / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D009529:Nicardipine / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats
D000959:Antihypertensive Agents; D010936:Plant Extracts; D003577:Cytochrome P-450 Enzyme System; D009529:Nicardipine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase