Stereochemical elucidation of the 1,4 polyketide amphidinoketide I.
The relative and absolute stereochemistry of amphidinoketide I has been determined by the total synthesis of all the diastereoisomers. Molecular modelling suggests that the natural product is not the thermodynamically preferred diastereoisomer.
Walsh
Louise M
LM
Unilever Centre for Molecular Informatics, Department of Chemistry, Lensfield Road, Cambridge, UK CB2 1EW.
Goodman
Jonathan M
JM
D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
D018942:Macrolides