The role of cytosolic phospholipase A2 in cell cycle progression.
Cytosolic phospholipase A2 (cPLA2) cleaves fatty acids from the sn-2 position of phospholipids resulting in the release of arachidonic acid. cPLA2 is activated upon phosphorylation, followed by a Ca(2+)-dependent translocation to cellular membranes. The activity of cPLA2 has been demonstrated to fluctuate during the M, G1 and S-phases of the cell cycle, and it has been shown recently that inhibition of the relatively high activity during the initial phases of the cell cycle results in a drastic reduction in S-phase entry. These findings demonstrate that in addition to a role in the inflammatory response, cPLA2 plays also an important regulatory role in cell cycle progression.
Department of Molecular Cell Biology, University Utrecht, Padualaan 8, 3584 CH, Utrecht, The Netherlands.
Johannes
J
Boonstra
Gerda S
GS
van Rossum
D000818:Animals; D002451:Cell Compartmentation / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003600:Cytosol / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D010741:Phospholipases A / Q000037:antagonists & inhibitors / Q000378:metabolism*; D054467:Phospholipases A2; D010743:Phospholipids / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D016196:S Phase / Q000502:physiology
D018797:Cell Cycle Proteins; D004791:Enzyme Inhibitors; D010743:Phospholipids; D010741:Phospholipases A; D054467:Phospholipases A2