Platelet adhesion on silicon modified hydrogenated amorphous carbon films.
We have investigated the effect of changes in microstructure, surface energy, surface charge condition and electronic conduction on the interaction of human platelets with silicon modified hydrogenated amorphous carbon films (a-C:H:Si or Si-DLC). Results based on Raman spectroscopy, Scanning electron microscopy, X-ray photo-electron spectroscopy, surface energy measurements, electrical resistivity, contact potential difference, and thermal annealing indicates a correlation between some of the measured values and the interaction of the films with human blood platelets. Statistical analysis of platelet aggregation on the films using the Student's t-test indicated differences between platelet aggregation on the modified films compared to the as-deposited film at a p-value of <0.05.
NIBEC, School of Electrical and Mechanical Engineering, University of Ulster, Shore road, BT37 OQB Northern Ireland, UK.
T I T
TI
Okpalugo
A A
AA
Ogwu
P D
PD
Maguire
J A D
JA
McLaughlin
D001672:Biocompatible Materials / Q000737:chemistry*; D001792:Blood Platelets / Q000502:physiology*; D002244:Carbon / Q000737:chemistry*; D002448:Cell Adhesion / Q000502:physiology*; D006801:Humans; D012825:Silicon / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D013696:Temperature
D001672:Biocompatible Materials; D002244:Carbon; D012825:Silicon