Uncinoside A and B, two new antiviral chromone glycosides from Selaginella uncinata.
Five compounds have been isolated from the dried whole plants of Selaginella uncinata, two of them were new chromone glycosides, 5-hydroxy-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside (uncinoside A) and 5-acetoxyl-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside (uncinoside B). Their structures were elucidated by spectroscopic methods including one- and two-dimensional NMR techniques. The other three compounds were identified as 8-methyl eugenitol, amentoflavone and hinokiflavone. Uncinoside A and B showed potent antiviral activities against respiratory syncytial virus (RSV) with IC(50) value of 6.9 and 1.3 microg/ml, moderate antiviral activities against parainfluenza type 3 virus (PIV 3) with IC(50) value of 13.8 and 20.8 microg/ml, respectively.
Department of Chinese Materia Medica and Natural Products, National Institute for the Control of Pharmaceutical & Biological Products, Beijing, 100050 P. R. China.
Ling-Yun
LY
Ma
Shuang-Cheng
SC
Ma
Feng
F
Wei
Rui-Chao
RC
Lin
Paul Pui-Hay
PP
But
Spencer Hon-Sun
SH
Lee
Song Fong
SF
Lee
D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002867:Chromones / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010224:Parainfluenza Virus 3, Human / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D012136:Respiratory Syncytial Viruses / Q000187:drug effects; D032503:Selaginellaceae / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014779:Virus Replication / Q000187:drug effects
C487289:5-acetoxyl-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside; C487288:5-hydroxy-2,6,8-trimethylchromone 7-O-beta-D-glucopyranoside; D000998:Antiviral Agents; D002867:Chromones; D010936:Plant Extracts