Stress/strain/life revisited. Quantification by blood pressure chronomics: benetensive, transtensive or maletensive chrono-vasculo-neuro-immuno-modulation.
We propose to initiate the automatic self-assessment of wear and tear as "stress and strain" by the time structures of blood pressure (BP) and heart rate (HR), in order to arrive eventually at an individualized timely and timed routine of life and to early preventive intervention as soon as needed. The routine may involve physiological scheduling of physical and mental activities and meals, and if need be of non-drug or drug treatment for stress amplification, e.g., by exercise, and/or strain (not stress) relief by relaxation. In so doing, we recognize the circulation as a pillar and marker of preventive and active neuroimmunomodulation (NIM), suggesting that some concerns of a vasculo- and broader NIM can be quantified by transdisciplinary chronobiology using its cartography--chronomics--of time structures, i.e., chronomes, from chronos = time and nomos = rule. Thus, we are introducing the chronomics of BP, HR and of other variables in the historical context of pioneers who were indispensable to experimental medicine. We build upon their contributions, but we must point out when, in the past, by necessity rather than choice, the giants provided rationalizing truisms that are no substitute for systematic serial data collection and appropriate computer analysis. A time-unspecified spotcheck as a baseline is much better than no measurement, but very often it is not enough, and it is always insufficient when an estimate of variability constitutes the information needed. For dynamic cycles, there are only reference cycles as a routine, although when maps are available, single timed spotchecks can be invaluable. With reference to their historical context, here we rely only upon data which necessity, rather than philosophy, compels us to collect.
Halberg
Franz
F
Halberg Chronobiology Center, University of Minnesota, MMC 8609, 420 Delaware St. SE, Minneapolis, MN 55455, USA. halbe001@umn.edu
Cornélissen
Germaine
G
Spector
Novera H
NH
Sonkowsky
Robert P
RP
Otsuka
Kuniaki
K
Baciu
Ion
I
Hriscu
Monica
M
Schwartzkopff
Othild
O
Bakken
Earl E
EE
D000203:Activities of Daily Living; D001794:Blood Pressure / Q000502:physiology*; D002909:Chronobiology Phenomena / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D015213:Neuroimmunomodulation / Q000502:physiology; D009626:Terminology as Topic