Microfluidic separation of DNA.
DNA separation is important for numerous applications in biotechnology and medicine. Efforts to improve DNA separation in microdevices have led to advances in capillary electrophoresis and the development of novel separation strategies. Current research on microcapillary electrophoresis materials is focused on the development of separation matrices with low injection viscosities and wall-coating capabilities. Microcapillary injector geometries are being designed to allow increased control of sample plug volumes. Novel separation strategies using entropic traps, arrays of pillars and Brownian ratchets are also being developed.
Ashton
Randolph
R
Howard P. Isermann Department of Chemical Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA. ashtor@rpi.edu
Padala
Chakradhar
C
Kane
Ravi S
RS
D004247:DNA / Q000032:analysis / Q000302:isolation & purification*; D004560:Electricity; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D011108:Polymers / Q000737:chemistry; D017422:Sequence Analysis, DNA; D014783:Viscosity
D011108:Polymers; D004247:DNA