Indium-mediated reaction of trialkylsilyl propargyl bromide with aldehydes: highly regioselective synthesis of allenic and homopropargylic alcohols.
High regioselective preparation of either the allenic alcohols or homopropargylic alcohols using the indium-mediated reaction of trialkylsilyl propargyl bromides with various aldehydes has been accomplished. By just changing the silyl groups and the reaction conditions, both the allenic and homopropargylic alcohols can be obtained in high regioselectivities.
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Man-Jing
MJ
Lin
Teck-Peng
TP
Loh