Synthesis of fullerene glycoconjugates through sulfide connection in aqueous media.
[reaction: see text] A thiolate/alkyl halide coupling reaction in aqueous media provides a one-step synthesis of fullerene glycoconjugates bearing five carbohydrate groups in good yield by using stoichiometric amounts of reactants, without recourse to hydroxy group protection. The sulfide-connection methodology is also useful for synthesis of simpler amphiphilic fullerene molecules, such as one bearing five carboxylic acid groups.
Department of Chemistry, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Hiroyuki
H
Isobe
Hiroko
H
Mashima
Hideki
H
Yorimitsu
Eiichi
E
Nakamura
D037741:Fullerenes / Q000737:chemistry*; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water / Q000737:chemistry
D037741:Fullerenes; D006001:Glycoconjugates; D014867:Water