Small-molecule inhibitors of the cell cycle: an overview.
Potent and selective small-molecule mediated inhibition of the cell's replication machinery remains a principal aim in the development of novel therapeutics and biological probes. Recent efforts have identified small molecules capable of arresting the cell cycle via specific interaction with a variety of intracellular protein targets. Advances in combinatorial and diversity oriented synthetic methods, coupled with a continued effort to identify sources of bioactive natural products, promise to contribute to the growing library of small-molecule inhibitors of the cell cycle.
Department of Molecular, Cellular, and Developmental Biology, Department of Chemistry, Department of Pharmacology, Yale University, New Haven, CT 06520, USA.
Craig M
CM
Crews
J Brad
JB
Shotwell
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D002453:Cell Cycle / Q000187:drug effects* / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000378:metabolism; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use
D018797:Cell Cycle Proteins; D004791:Enzyme Inhibitors; D047428:Protein Kinase Inhibitors; D011500:Protein Synthesis Inhibitors; D011494:Protein Kinases; D000251:Adenosine Triphosphatases