Catalytic, asymmetric synthesis of cyanohydrin ethyl carbonates.
[reaction: see text] The bimetallic titanium complex [(salen)TiO](2), where salen is the ligand derived from (R,R)-cyclohexanediamine and 3,5-di-tert-butyl-salicylaldehyde, has been shown to catalyze the asymmetric addition of ethyl cyanoformate to aldehydes leading to cyanohydrin carbonates with high enantiomeric excesses.
A.N. Nesmeyanov Institute of Organo-Element Compounds, Russian Academy of Sciences, 117813, Moscow, Vavilov 28, Russian Federation.
Yuri N
YN
Belokon'
A John
AJ
Blacker
Lisa A
LA
Clutterbuck
Michael
M
North