Optical response of the cultured bovine lens; testing opaque or partially transparent semi-solid/solid common consumer hygiene products.
This study determines the relative ocular lens irritancy of 16 common partially transparent or non-transparent consumer hygiene products. The irritancy was found by measuring the changes in the sharpness of focus [referred to as the back vertex distance (BVD) variability] of the cultured bovine lens using a scanning laser In Vitro Assay System. This method consists of a laser beam that scans across the lens, and a computer, which then analyses the average focal length (mm), the BVD variability (mm), and the intensity of the beam transmitted. Lenses were exposed to the 16 hygiene products and the lens' focusing ability was monitored over 192 h. The products are semi-solids or solids (e.g. gels, lotions, shampoos). They are categorized into six groups: shampoos, body washes, lotions, toothpastes, deodorant, and anti-perspirant. Damage (measured by > 1 mm BVD variability) occurred slower for the shampoos, especially in the case of baby shampoo. The results indicate that shampoos exhibit the lowest level of ocular lens toxicity (irritability) while the deodorant is the most damaging.
School of Optometry, University of Waterloo, Waterloo, ON, Canada N2L 3G1.
W
W
Wong
J G
JG
Sivak
K L
KL
Moran
D000818:Animals; D002417:Cattle; D003257:Consumer Product Safety; D006795:Household Products / Q000145:classification / Q000633:toxicity*; D007509:Irritants / Q000145:classification / Q000633:toxicity*; D007834:Lasers; D007908:Lens, Crystalline / Q000187:drug effects* / Q000502:physiology; D009924:Organ Culture Techniques; D012029:Refraction, Ocular / Q000187:drug effects* / Q000502:physiology; D018675:Toxicity Tests / Q000379:methods*
D007509:Irritants