West nile virus encephalitis involving the substantia nigra: neuroimaging and pathologic findings with literature review.
West Nile virus has become a medically important arbovirus in the continental United States with its debut in 1999 in the New York City area. We present neuroimaging features and pathologic findings in 2 patients who were severely affected out of the more that 100 documented cases at our institution. Both patients showed striking involvement of the substantia nigra, a finding not previously reported for West Nile virus.
Department of Diagnostic Radiology, William Beaumont Hospital, Royal Oak, Mich 48073, USA. cmbosanko@yahoo.com
Carol Mae
CM
Bosanko
John
J
Gilroy
Ay-Ming
AM
Wang
William
W
Sanders
Mohanpal
M
Dulai
Jon
J
Wilson
Keith
K
Blum
D000368:Aged; D001921:Brain / Q000473:pathology; D001929:Brain Edema / Q000209:etiology / Q000473:pathology; D003128:Coma / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D013226:Status Epilepticus / Q000209:etiology; D013378:Substantia Nigra / Q000473:pathology*; D014901:West Nile Fever / Q000150:complications / Q000473:pathology* / Q000523:psychology