Regulation of E-kinase mediated cell-adhesion molecule(s) function by E-NTPase(s): imminent regulatory inter-dependency for cell adhesion.
E-NTPase is a cell membrane bound enzyme, suggested to play a role in maintaining the [NTP](o) and cell adhesion. Attempts to purify this enzyme resulted identification of many proteins co-purifying with E-NTPase. The amino acid sequence of chicken gizzard smooth muscle E-NTPase has been shown to have considerable amino acid sequence homology with mammalian CD39. On the other hand, the purified rat cardiac sarcolemmal E-NTPase showed identical sequence homology with platelet CD36. In this communication, an effort was made to provide rationale for the functional relevance of E-NTPase with reference to cell-adhesion process.
University of Pennsylvania, Philadelphia, PA 19104, USA. sukannan@utmb.edu
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D000251:Adenosine Triphosphatases / Q000096:biosynthesis / Q000737:chemistry; D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis / Q000737:chemistry; D001081:Apyrase; D001792:Blood Platelets / Q000378:metabolism; D018955:CD36 Antigens / Q000096:biosynthesis; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D002645:Chickens; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D008962:Models, Theoretical; D009130:Muscle, Smooth / Q000378:metabolism; D043583:Nucleoside-Triphosphatase / Q000502:physiology*; D010766:Phosphorylation; D051381:Rats
D015703:Antigens, CD; D018955:CD36 Antigens; D015815:Cell Adhesion Molecules; D000251:Adenosine Triphosphatases; D043583:Nucleoside-Triphosphatase; D001081:Apyrase; C067869:CD39 antigen