Novel role for albumin in innate immunity: serum albumin inhibits the growth of Blastomyces dermatitidis yeast form in vitro.
In this study we found that serum inhibitory activity against Blastomyces dermatitidis was principally mediated by albumin. This was confirmed in experiments using albumin from several mammalian species. Analbuminemic rat serum did not inhibit B. dermatitidis growth in vivo; however, the addition of albumin restored inhibitory activity. Inhibitory activity does not require albumin domain III and appears to involve binding of a low-molecular-weight yeast-derived growth factor.
Giles
Steven
S
Department of Pathobiological Sciences, School of Veterinary Medicine, Madison, Wisconsin 53706, USA.
Czuprynski
Charles
C
D000818:Animals; D001758:Blastomyces / Q000187:drug effects* / Q000254:growth & development; D002417:Cattle; D006801:Humans; D007113:Immunity, Innate; D051381:Rats; D044967:Serum / Q000502:physiology*; D012709:Serum Albumin / Q000737:chemistry / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000494:pharmacology
D012709:Serum Albumin; D012710:Serum Albumin, Bovine