A novel four-component reaction for the synthesis of functionalised dihydropyrimidines.
In a multi-component reaction (MCR) of a phosphonate, nitriles, aldehydes and isocyanates, N3-functionalised dihydropyrimidines can be synthesised efficiently via a Horner-Emmons/aza Diels-Alder pathway.
Vugts
Danielle J
DJ
Department of Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
Jansen
Helen
H
Schmitz
Rob F
RF
de Kanter
Frans J J
FJ
Orru
Romano V A
RV