[Studies on the blood group serologic characters of enzyme-only red cell antibody].
The objective of this study was to investigate the serologic characters of enzyme-only red cell antibody and its clinical significance, and to provide basis for the safety of blood transfusion. The patient serum containing enzyme-only antibody was used to react with the red cells of donors, panel cells and auto-cells in various medium. Absorption and elution test were also per formed. The results showed that this blood sample was found to contain an antibody that reacted with donor red cells and panel cells only in papain medium, but was not demonstrable by indirect antiglobulin test and other method s. Decline of antibody titers was observed after absorption test, but antibody activity was not detected in the elute. The patient underwent transfusion with 600 ml of Rh type identical RBCs, without any hemolytic transfusion reaction. In conclusion, enzyme-only antibody usually doe s not lead to hemolytic transfusion reaction.
Ma
Shu-Xuang
SX
Department of Blood Transfusion, The General Hospital of PLA, Center for Clinic Blood Transfusion Medicine of PLA, Beijing 100853.
Liu
Jing-Han
JH
Ouyang
Xi-Lin
XL
Li
Xi-Jin
XJ
Yu
Yang
Y
Ma
Xiao-Min
XM
Lai
Feng-Lei
FL
D000368:Aged; D000369:Aged, 80 and over; D004912:Erythrocytes / Q000276:immunology*; D006461:Hemolysis; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D008297:Male; D010206:Papain / Q000494:pharmacology*; D065227:Transfusion Reaction
D007518:Isoantibodies; D010206:Papain