[Unrelated HLA-mismatched cord blood transplantation using nonmyeloablative conditioning in an adult patient with very severe aplastic anemia].
An adult patient suffering from G-CSF-resistant very severe aplastic anemia received a cord blood transplantation from a three-loci HLA-mismatched unrelated donor after nonmyeloablative conditioning. Cord blood was infused after conditioning with fludarabine (180 mg/m2) and cyclophosphamide (100 mg/kg). Cyclosporin A and short-term methotrexate were used for prophylaxis against acute GVHD. Engraftment was achieved on day 23, and there was no serious GVHD. A full-donor type T-cell chimerism was obtained by day 30. Normal hematopoiesis and complete chimerism have been maintained 14 months after transplantation.
First Department of Internal Medicine, Kansai Medical University.
Yasuhiko
Y
Miyazaki
Naoto
N
Nakamichi
Noriaki
N
Matsumoto
Katsuhiro
K
Zen
Ryuichi
R
Amakawa
Yuji
Y
Kishimoto
Shirou
S
Fukuhara
D000328:Adult; D000741:Anemia, Aplastic / Q000276:immunology / Q000628:therapy*; D005260:Female; D005312:Fetal Blood / Q000637:transplantation*; D006680:HLA Antigens / Q000276:immunology*; D006648:Histocompatibility / Q000276:immunology*; D006801:Humans; D019172:Transplantation Conditioning
D006680:HLA Antigens