Molecular pathogenesis of neuroinflammation.
The past few years have seen significant progress towards understanding the mechanisms of immune surveillance and inflammation in the nervous system. In this review, the milestones of scientific discovery in this field are discussed, and the strengths and limitations of the different ways of examining the molecular pathogenesis of neuro-inflammation examined. The review is limited to the inflammatory reactions of the central nervous system that occur in multiple sclerosis and experimental autoimmune encephalomyelitis.
Bradl
M
M
Institute for Brain Research, Department of Neuroimmunology, Vienna, Austria. monika.bradl@univie.ac.at
Hohlfeld
R
R
D002493:Central Nervous System Diseases / Q000235:genetics / Q000276:immunology* / Q000473:pathology*; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation; D009103:Multiple Sclerosis / Q000276:immunology / Q000503:physiopathology; D020411:Oligonucleotide Array Sequence Analysis