Selective association of cholesterol with long-chain phospholipids in liquid-ordered bilayers: support for the existence of lipid rafts.
Nearest-neighbor recognition experiments, which have been carried out under fluidizing and condensing conditions, using exchangeable dimers derived from 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine, and cholesterol, have provided strong evidence that sterol-phospholipid recognition is limited to the liquid-ordered phase.
Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA.
Michihiro
M
Sugahara
Maki
M
Uragami
Steven L
SL
Regen
D002784:Cholesterol / Q000737:chemistry*; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry*; D021962:Membrane Microdomains / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry*
D008051:Lipid Bilayers; D010743:Phospholipids; D002784:Cholesterol