Darier's disease associated with an underlying neoplasm in combination with a nodular fibroproliferative disease.
Darier's disease is an autosomal dominant disease that typically arises during the first or second decades of life. It involves the abnormal keratinization of the epidermis, mucosa, and nails. We describe a 74-year-old man with metastatic carcinoma in whom fibroproliferative disease and an acquired variant of Darier's disease developed, both of which may have been paraneoplastic processes.
Dortzbach
Kathryn L
KL
Department of Dermatology, The Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
Seykora
John T
JT
Werth
Victoria P
VP
D000230:Adenocarcinoma / Q000150:complications / Q000175:diagnosis* / Q000556:secondary; D000368:Aged; D001415:Back; D007644:Darier Disease / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D017495:Hyperpigmentation / Q000209:etiology / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D009262:Nails; D009382:Neoplasms, Unknown Primary / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D013405:Suicide