Heritability and candidate genes for endometriosis.
Endometriosis is inherited in polygenic/multifactorial fashion, with recurrence risks of 5-7% for first-degree relatives. The current task is to determine the number and location of causative genes. This review initially supports the basis for polygenic/multifactorial inheritance and then outlines genome-wide strategies for identifying causative genes. Potential candidate genes are surveyed, and discrepant results emphasized. Finally, a hypothesis for endometriosis, having a multi-step pathogenesis analogous to the pathogenesis of neoplasia, is considered.
Simpson
Joe Leigh
JL
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030, USA. jsimpson@bcm.tmc.edu
Bischoff
Farideh
F
D004715:Endometriosis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans