Blood coagulation and fibrinolysis of rats fed fish oil: reduced coagulation factors especially involved in intrinsic pathway and increased activity of plasminogen activator inhibitor.
Differences in the coagulation and fibrinolytic system of rats fed a fish oil based diet (fish oil diet) and fed a soybean oil based diet (control diet) were determined. Concentrations of plasma lipids were depressed in rats fed the fish oil diet. Prothrombin time (PT) and activated partial thromboplastin time (APTT) of rats fed the fish oil diet were longer than for the rats fed the control diet. Fish oil intake lowered the activities of most of the blood coagulation factors, and strongly depressed the factors involved in the intrinsic pathway. Fish oil also affected the fibrinolysis of rats. Plasminogen activator inhibitor (PAI) activity was elevated in rats fed the fish oil diet. In this study, both blood coagulation and fibrinolysis were down-regulated by feeding the fish oil diet.
Laboratory of Applied Microorganisms, Marine Biochemistry Division, National Research Institute of Fisheries Science, Fisheries Research Agency, Yokohama, Japan. ysano@affrc.go.jp
Yoko
Y
Sano
Kaori
K
Sato
Motoharu
M
Uchida
Masakazu
M
Murata
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D005342:Fibrinolysis / Q000187:drug effects*; D005395:Fish Oils / Q000008:administration & dosage / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D015849:Plasminogen Inactivators / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013024:Soybean Oil / Q000008:administration & dosage / Q000494:pharmacology
D001779:Blood Coagulation Factors; D005395:Fish Oils; D008055:Lipids; D015849:Plasminogen Inactivators; D013024:Soybean Oil