Langerhans cell histiocytosis with periorbital cellulitis.
OBJECTIVE
To report a case of Langerhans cell histiocytosis presenting as periorbital cellulitis.


METHODS
Interventional case report.


METHODS
A 3-year-old girl presented with periorbital swelling of the right upper lid laterally of two days' duration. A history of recent eye trauma was reported.


RESULTS
Computed tomography showed a soft tissue mass that eroded the frontozygomatic suture. The lesion was debulked through a lateral orbitotomy. Electron microscopy disclosed Birbeck granules. Immunohistochemistry stained positively for CD68 and CD1a antigenic determinants.


CONCLUSIONS
Although rare, Langerhans cell histiocytosis can cause acute periorbital cellulitis in children. Trauma can induce an inflammatory response, allowing for earlier diagnosis of the orbital lesion.
Department of Ophthalmology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel. levy_jaime@hotmail.com
Jaime
J
Levy
Tova
T
Monos
Joseph
J
Kapelushnik
Esther
E
Maor
Michael
M
Nash
Tova
T
Lifshitz
D015703:Antigens, CD / Q000378:metabolism; D018949:Antigens, CD1 / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D002443:Ceftriaxone / Q000627:therapeutic use; D002481:Cellulitis / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D009916:Orbital Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D009418:S100 Proteins / Q000378:metabolism; D013122:Spinal Diseases / Q000175:diagnosis; D014057:Tomography, X-Ray Computed; D014746:Vimentin / Q000378:metabolism; D000097382:CD68 Molecule
D015703:Antigens, CD; D018949:Antigens, CD1; D015214:Antigens, Differentiation, Myelomonocytic; D002443:Ceftriaxone; D009418:S100 Proteins; D014746:Vimentin; C419393:CD1a antigen; C067980:CD68 antigen, human; D000097382:CD68 Molecule