Role of resection for newly diagnosed malignant gliomas.
The surgical neuro-oncology literature testifies to the longstanding argument about the benefits (or lack thereof) of aggressive debulking of high-grade gliomas. Publications from the last decade addressing this question will be reviewed. The absence of randomized clinical trials and paucity of prospectively collected information continue to leave this issue unresolved, although most evidence continues to support a modest benefit of debulking over biopsy.
Department of Neurology, University of Virginia Health Science Center, Charlottesville 22908, USA. ds4jd@virginia.edu
David
D
Schiff
Mark E
ME
Shaffrey
D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005910:Glioma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D006801:Humans; D019635:Neurosurgical Procedures; D011788:Quality of Life; D013534:Survival