[Platelet aggregation test: application in the control of antiplatelet aggregation in the secondary prevention of stroke].
BACKGROUND
Stroke is the leading cause of death in Brazil. The risk of suffering a recurrent stroke is around 30% in 5 years. Antiplatelet therapy has been frequently used to prevent recurrent strokes without laboratory control.


OBJECTIVE
To determine the value of the platelet aggregation test in the control of antiplatelet aggregation in the secondary stroke prevention.


METHODS
Retrospective study from January 1990 to January 2001 with 189 patients with stroke that were followed up during this period with platelet aggregation curve. Patients with cardioembolic disease were excluded. Low aggregation rates of platelet aggregation activated by ADP and/or epinephrine lower or equal to 50% were considered. Patients were followed up for a period from one to six years to verify differences in stroke recurrence.


RESULTS
Nine patients had had a recurrent stroke; 2,6% of the strokes occurred among the group with low aggregaton and 15,1% among the group with normal aggregation (0,03<OR<0,69, p<0,05). Most of the cases occurred in the second year after the first stroke.


CONCLUSIONS
Platelet aggregation curve is a valid and a helpful laboratory test to therapeutic control of antiplatelet aggregation in secondary stroke prevention.
Faculdade de Ciências Médicas da Santa Casa de São Paulo, São Paulo, SP, Brasil.
Patrícia Regina
PR
Piedade
Rubens José
RJ
Gagliardi
Ibsen Thadeo
IT
Damiani
Antonio Paulo
AP
Nassar Junior
Melissa Martins
MM
Fuzaro
Wilson Luiz
WL
Sanvito
D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010979:Platelet Function Tests; D012008:Recurrence; D012189:Retrospective Studies; D020521:Stroke / Q000517:prevention & control*
D010975:Platelet Aggregation Inhibitors