[Induction of SOS-response of cells exposed to autoregulatory factors of microorganisms].
Among examined microbial growth regulators of alkyl hydroxybenzene group (hexylresorcinol, methylresorcinol, and hydroxyethylphenol), only hexylresorcinol induces cellular SOS response, demonstrating a dose-dependent increase of the induction factor in the SOS chromotest with the Escherichia coli PQ37 strain. At the highest of used concentrations (100 micrograms/ml), hydroxyethylphenol and nonalkylated resorcinol were shown to exert a weak toxic effect, reducing the activity of constitutive alkaline phosphatase, but did not induce SOS response. Nontoxic methylresorcinol did not induce genome damage, which can trigger SOS functions. It is concluded that substitutions in phenolic ring affect genotoxic activity of alkylresorcinols.
Margulis
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Department of Microbiology, Kazan State University, Kazan, 420008, Tatarstan, Russia.
Il'inskaia
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ON
Kolpakov
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El-Registran
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D001419:Bacteria / Q000235:genetics* / Q000254:growth & development; D019800:Phenol / Q000494:pharmacology*; D013014:SOS Response, Genetics / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000254:growth & development / Q000502:physiology*
D019800:Phenol