Alkaloids from Croton flavens L. and their affinities to GABA-receptors.
Phytochemical investigation of several plants of Croton flavens L. from Barbados has led to the isolation of the tetrahydroprotoberberine alkaloids scoulerine and coreximine, as well as the morphinanedienones salutaridine and its racemic form salutarine, sebiferine, norsinoacutine and flavinantine. In a screening for 3H-GABA displacing activity coreximine showed the highest affinity to the GABA(A) receptor.
Department für Pharmazie-Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität, Butenandtstr. 5-13, 81377 München, Germany.
Wolfram J
WJ
Eisenreich
Georg
G
Höfner
Franz
F
Bracher
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000502:physiology; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D029802:Croton / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D018515:Plant Leaves / Q000737:chemistry; D018079:Receptors, GABA / Q000187:drug effects* / Q000502:physiology
D000470:Alkaloids; D018079:Receptors, GABA