Metastatic ovarian Sertoli-cell tumor: FNA findings with immunohistochemistry.
A malignant Sertoli cell tumor of the ovary is a rare sex-cord stromal derived neoplasm. Sertoli cell tumors account for approximately 4% of Sertoli-stromal cell tumors (Hsu et al., J Histochem Cytochem 1981;29:577-580). The diagnosis of this entity by fine-needle aspiration and needle core biopsy can be difficult when the differential also includes a metastatic renal cell carcinoma, due to the overlap of both cytological and histological features. Here, we show that immunohistochemical staining on cytological material including alpha-inhibin can be used to differentiate between these two malignant tumors.
Watson
Brian
B
Department of Pathology and Immunology, The Lauren V. Ackerman Laboratory of Surgical Pathology, Washington University Medical School, St. Louis, Missouri, USA.
Siegel
Cary L
CL
Ylagan
Lourdes R
LR
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007265:Inhibins / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000473:pathology; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D012707:Sertoli Cell Tumor / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor; C094377:inhibin-alpha subunit; D007265:Inhibins