Superior performance of a paraaortic counterpulsation device compared to the intraaortic balloon pump.
The purpose of this study was to compare the hemodynamic effectiveness of a 30-ml stroke volume paraaortic counterpulsation device (PACD), presenting the advantages of ease of implantation and driving by a standard intraaortic balloon pump (IABP) console (Datascope 96, Datascope Corp., Montvale, NJ, USA) to that of a 40-ml IABP, in the setting of experimental heart failure. In an acute heart failure model, the IABP was placed in the descending aorta and the PACD in the ascending aorta of eight pigs. Both devices were driven by the same system, and hemodynamic measurements were obtained with and without mechanical assistance. The two pumps significantly reduced the systolic and end-diastolic aortic pressures, but the PACD reduced the latter more effectively (42.6 +/- 18.1% vs 11.0 +/- 9.9%, p = 0.0001). Both pumps provided significant aortic diastolic augmentation, but the counterpulsation wave of the PACD was significantly greater (augmentation of 44.8 +/- 22.2% vs 37.6 +/- 15.6%, p = 0.031). Both lowered the end-diastolic left ventricular pressure with a trend toward PACD superiority (24.2 +/- 13.7% vs 19.7 +/- 13.5%, p = 0.064). It is concluded that the PACD, even with smaller stroke volume, is more effective than the IABP. The simplicity of its implantation, together with the ability of the standard IABP consoles to control its function, make it a promising device for mechanical assistance of the failing heart.
University of Athens School of Medicine, Department of Clinical Therapeutics, "Alexandra" Hospital, 80 Vas Sofias Av and K. Lourou, 115 28, Athens, Greece.
John V
JV
Terrovitis
Christos E
CE
Charitos
Elias J
EJ
Tsolakis
Paraskevi
P
Dolou
Charalampos N
CN
Pierrakos
Kostas X
KX
Siafakas
John N
JN
Nanas
D000818:Animals; D015908:Counterpulsation / Q000295:instrumentation*; D004195:Disease Models, Animal; D004867:Equipment Design; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy*; D006439:Hemodynamics; D007423:Intra-Aortic Balloon Pumping / Q000295:instrumentation; D013552:Swine