Synthesis and antagonistic activity of four new 2-alkyl-N-biphenyl fused imidazoles on angiotensin II receptors.
In the current study, four new 2-alkyl-N-biphenyl fused imidazoles were synthesized and the pharmacological properties of these compounds as angiotensin II antagonists were studied. First, the potency of the synthesized compounds on guinea-pig ileum was evaluated and the vasopressor effect of the most potent compound 6a was compared with losartan on isolated perfused rat kidney. The antagonistic activity of compound 6a (sodium 2-propyl-5-carbomethoxy-1-[(biphenyl-4-yl)methyl]pyrrolo[3,2-d]imidazole-2'-carboxylate) on angiotensin II receptors was greater than the other synthesized compounds and in isolated perfused rat kidney was similar to losartan.
Akhavan
Maziar M
MM
Razi Institute for Drug Research, Iran University of Medical Sciences, Shaheed Hemmat Expressway, Tehran, Iran.
Mojarrad
Javid Shahbazi
JS
Rouzrokh
Ali
A
Ebrahimi
Sultan A
SA
Mahmoudian
Massoud
M
Shafiee
Abbas
A
D000804:Angiotensin II / Q000494:pharmacology; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011945:Receptors, Angiotensin / Q000502:physiology; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology
D057911:Angiotensin Receptor Antagonists; D007093:Imidazoles; D011945:Receptors, Angiotensin; D000804:Angiotensin II