An automatic ambulatory device for detection of AASM defined arousals from sleep: the WP100.
OBJECTIVE
Arousals from sleep are associated with increased sympathetic activation and therefore with peripheral vasoconstriction. Sleep fragmentation in the form of multiple arousals is associated with daytime somnolence and cognitive impairment; however, manual scoring of arousal is time consuming and problematic due to relatively high inter-scorer variability. We have recently shown that automated analysis of in-lab recorded peripheral arterial tone (PAT) signal and the pulse rate derived from it can accurately assess arousals from sleep as defined by the American Academy of Sleep Medicine (AASM). In the current study we sought to extend these findings to the Watch_PAT100 (WP100), an ambulatory device measuring PAT, oximetry and actigraphy.


METHODS
Sixty-eight subjects (61 patients referred to the sleep lab with suspected obstructive sleep apnea and seven healthy volunteers, mean age 46.3+/-14.2 years) underwent a whole night polysomnography (PSG) with simultaneous recording of PAT signal by the ambulatory WP100 device. The PSG recordings were blindly manually analyzed for arousals based on AASM criteria, while PAT was scored automatically based on the algorithm developed previously.


RESULTS
There was a significant correlation between AASM arousals derived from the PSG and PAT autonomic arousals derived from the WP100 (R=0.87, P<0.001), with a good agreement across a wide range of values. The sensitivity and specificity of PAT in detecting patients with at least 20 arousals per hour of sleep were 0.80 and 0.79, respectively, with a receiver operating characteristic curve having an area under the curve of 0.87.


CONCLUSIONS
We conclude that automatic analysis of peripheral arterial tonometry signal derived from the ambulatory device Watch_PAT100 can accurately identify arousals from sleep in a simple and time saving fashion.
Sleep Laboratory, Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel. gpillar@tx.technion.ac.il
Giora
G
Pillar
Amir
A
Bar
Michal
M
Betito
Robert P
RP
Schnall
Itsik
I
Dvir
Jacob
J
Sheffy
Peretz
P
Lavie
D000328:Adult; D001143:Arousal; D006801:Humans; D008875:Middle Aged; D018670:Monitoring, Ambulatory / Q000295:instrumentation* / Q000592:standards; D010991:Plethysmography / Q000295:instrumentation* / Q000592:standards; D017286:Polysomnography; D012015:Reference Standards; D015203:Reproducibility of Results; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis*; D012955:Societies, Medical