Modulation of DNA repair processes by arsenic and selenium compounds.
Nickel, cadmium, cobalt and arsenic compounds are well known carcinogens to humans and experimental animals. In addition to the induction of mainly oxidative DNA damage, they interfere with nucleotide and base excision repair (BER) at low, non-cytotoxic concentrations. In case of arsenic, an inactivation of DNA repair has also been observed for the trivalent and pentavalent methylated metabolites, with the strongest effects exerted by MMA(III) and DMA(III). As potential molecular targets, interactions with so-called zinc finger proteins involved in DNA repair and/or DNA damage signaling have been identified. For example, arsenite suppresses poly(ADP-ribosyl)ation at extremely low, environmentally relevant concentrations. Also, Fpg and XPA involved in BER and NER, respectively, are inactivated by arsenite, MMA(III) and DMA(III). Nevertheless, an interaction with the zinc finger structures of DNA repair proteins may also occur by essential trace elements such as certain selenium compounds, which appear to exert anticarcinogenic properties at low concentrations but may compromise genetic stability at higher concentrations.
Institut für Lebensmittelchemie und Toxikologie, Universität Karlsruhe, Postfach 6980, D-76128 Karlsruhe, Germany. andrea.hartwig@chemie.uni-karlsruhe.de
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Hartwig
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Blessing
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Schwerdtle
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Walter
D000818:Animals; D001152:Arsenicals / Q000494:pharmacology*; D004260:DNA Repair / Q000187:drug effects*; D045643:DNA Repair Enzymes / Q000378:metabolism; D006801:Humans; D018036:Selenium Compounds / Q000494:pharmacology*; D016335:Zinc Fingers / Q000502:physiology
D001152:Arsenicals; D018036:Selenium Compounds; D045643:DNA Repair Enzymes