A novel four-component reaction for the synthesis of functionalised dihydropyrimidines.
In a multi-component reaction (MCR) of a phosphonate, nitriles, aldehydes and isocyanates, N3-functionalised dihydropyrimidines can be synthesised efficiently via a Horner-Emmons/aza Diels-Alder pathway.
Department of Chemistry, Vrije Universiteit Amsterdam, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands.
Danielle J
DJ
Vugts
Helen
H
Jansen
Rob F
RF
Schmitz
Frans J J
FJ
de Kanter
Romano V A
RV
Orru