Novel poly(amino ester)s obtained from Michael addition polymerizations of trifunctional amine monomers with diacrylates: safe and efficient DNA carriers.
Novel biodegradable poly(amino ester)s containing secondary and tertiary amines in the backbones were obtained from the Michael addition polymerizations of trifunctional amine monomers with diacrylates, and showed high transfection efficiency for the delivery of DNA comparable to those of polyethylenimine (PEI) and low cytotoxicity.
Liu
Ye
Y
Institute of Materials Research and Engineering, 3 Research Link, Singapore 117602. ye-liu@imre.a-star.edu.sg
Wu
Decheng
D
Ma
Yuexia
Y
Tang
Guping
G
Wang
Shu
S
He
Chaobin
C
Chung
Taishung
T
Goh
Suathong
S
D000179:Acrylates / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D001673:Biodegradation, Environmental; D002460:Cell Line; D004247:DNA / Q000008:administration & dosage; D005822:Genetic Vectors / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D015394:Molecular Structure; D010957:Plasmids; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D011091:Polyesters / Q000138:chemical synthesis / Q000633:toxicity; D011094:Polyethyleneimine / Q000633:toxicity; D014162:Transfection / Q000379:methods*
D000179:Acrylates; D000588:Amines; D011073:Polyamines; D011091:Polyesters; D011094:Polyethyleneimine; D004247:DNA