[The number of aberrations in aberrant cells as a parameter of chromosomal instability. 1. Characterization of dose dependency].
Analysis of chromosome instability (CI) is of great importance in view of pollution of the environment by genotoxic factors. Frequency of aberrant cells, spectrum of chromosome aberrations, damages of aberrant cell and distribution of aberrations in the cells are the most conventional parameters of CI. We have carried out the comparative analysis of the frequency of aberrant cells and the dynamics of aberrant cell damages induced by different mutagenic factors (alpha-irradiation from 241Am, gamma-irradiation from 60Co and tioTEPA) in Allium-test. This comparative analysis denotes that the studied parameters have different dynamics characterizing different mechanisms of CI in Allium cepa L.
N K
NK
Kutsokon'
V F
VF
Bezrukov
L M
LM
Lazarenko
N M
NM
Rashydov
D M
DM
Hrodzyns'kyĭ
D000490:Allium / Q000187:drug effects / Q000235:genetics / Q000528:radiation effects; D000512:Alpha Particles / Q000009:adverse effects; D000576:Americium / Q000633:toxicity; D018906:Antineoplastic Agents, Alkylating / Q000528:radiation effects; D002869:Chromosome Aberrations; D003037:Cobalt Radioisotopes / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays / Q000009:adverse effects; D009153:Mutagens; D013852:Thiotepa / Q000528:radiation effects
D018906:Antineoplastic Agents, Alkylating; D003037:Cobalt Radioisotopes; D009153:Mutagens; D013852:Thiotepa; D000576:Americium