A function for subtelomeric DNA in Saccharomyces cerevisiae.
The subtelomeric DNA sequences from chromosome I of Saccharomyces cerevisiae are shown to be inherently poor substrates for meiotic recombination. On the basis of these results and prior observations that crossovers near telomeres do not promote efficient meiosis I segregation, we suggest that subtelomeric sequences evolved to prevent recombination from occurring where it cannot promote efficient segregation.
Department of Microbiology and Molecular Genetics, International Center for Public Health, UMDNJ-New Jersey Medical School, Graduate School of Biomedical Sciences, Newark, New Jersey 07103, USA.
Arnold B
AB
Barton
Yuping
Y
Su
Jacque
J
Lamb
Dianna
D
Barber
David B
DB
Kaback
D004247:DNA / Q000502:physiology*; D011995:Recombination, Genetic / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000502:physiology; D016615:Telomere / Q000235:genetics*
D004247:DNA