Ribosomes rule: translation, not transcription, is the primary target of two major intercellular signaling pathways.
Many investigations have focused on how signaling pathways influence the transcription of specific target genes. However, a new report by Rajasekhar et al. indicates that the Ras and Akt pathways have a much stronger influence on the association of mRNAs with polysomes than on the levels of those mRNAs themselves.
Lasko
Paul
P
Department of Biology, McGill University, Montréal, Québec, Canada.
D000818:Animals; D020869:Gene Expression Profiling; D014176:Protein Biosynthesis; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt; D012333:RNA, Messenger / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014158:Transcription, Genetic; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism
D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D018631:ras Proteins