A whole genome association study in Finnish multiple sclerosis patients with 3669 markers.
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with complex genetic background. In the present study, based in the Finnish population, we typed a large number of microsatellite markers in separately pooled DNA samples from 195 MS patients and 205 controls. A total of 108 markers showed evidence of association. Five genomic regions containing two or more of these markers within a 1-Mb interval were identified, 1q43, 2p16, 4p15, 4q34 and 6p21 (the MHC region). Substantial overlap with previously published linkage genome screens is also seen.
Laaksonen
M
M
Turku Immunology Center and Department of Virology, University of Turku, Kiinamyllynkatu 13, FIN 20520 Turku, Finland. miklaa@utu.fi
Jonasdottir
A
A
Fossdal
R
R
Ruutiainen
J
J
Sawcer
S
S
Compston
A
A
Benediktsson
K
K
Thorlacius
T
T
Gulcher
J
J
Ilonen
J
J
D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D005787:Gene Frequency; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D020161:Physical Chromosome Mapping / Q000706:statistics & numerical data; D016133:Polymerase Chain Reaction / Q000706:statistics & numerical data