Assembling polycyclic bisguanidine motifs resembling batzelladine alkaloids by double tethered Biginelli condensations.
[reaction: see text] Double tethered Biginelli condensations furnish linked polycyclic bisguanidines or bisureas. Alteration of the bis-beta-ketoester component allows bispolycyclic guanidine motifs to be constructed that resemble natural batzelladine alkaloids or have novel linkages.
Cohen
Frederick
F
Department of Chemistry, 516 Rowland Hall, University of California-Irvine, Irvine, California, 92697-2025, USA.
Collins
Shawn K
SK
Overman
Larry E
LE
D000470:Alkaloids / Q000737:chemistry*; D019791:Guanidine / Q000737:chemistry*
D000470:Alkaloids; D019791:Guanidine