[Antibacterial effect of two glycine betaine analogues against Escherichia coli].
Strains of enterobacteria that cause urinary tract infections are able to grow in urine with high tonicity. In such conditions bacterias adapt to osmotic forces by incorporation of osmoprotectant compounds including glycine betaine. Accumulation of toxic analogues in bacteria, using inducible betaine transporters, has been previously proposed for development of antibiotics. In this study we report antibacterial effect of two analogues against 82 strains of Escherichia coli isolated form urinary tract infections. Minimal inhibitory concentrations have been measured with and without osmotic stress. The betaine analogues have antibacterial effect against E. coli strains, but only in presence of an osmotic stress.
Upres-EA 1254, microbiologie, université Rennes I, 2, avenue du Professeur-Léon-Bernard, 35043 Rennes, France.
M
M
Quéau
J
J
Renault
P
P
Uriac
J-C
JC
Corbel
M-F
MF
Travert
T
T
Bernard
P-Y
PY
Donnio
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001622:Betaine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013314:Stress, Mechanical
D000900:Anti-Bacterial Agents; D001622:Betaine