Asymmetric synthesis of 4,4-disubstituted-2-imidazoli-dinones: potent NK1 antagonists.
[structure: see text] A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a "self-reproduction of the center of chirality" strategy is described.
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA.
Gregory A
GA
Reichard
Carmine
C
Stengone
Sunil
S
Paliwal
Ingrid
I
Mergelsberg
Sapna
S
Majmundar
Cheng
C
Wang
Robert
R
Tiberi
Andrew T
AT
McPhail
John J
JJ
Piwinski
Neng-Yang
NY
Shih