Planning of empirical antibiotic therapy for women with pelvic inflammatory diseases: a geographical area-specific study.
OBJECTIVE
Elaboration of an empiric antibiotic regimen for women with pelvic inflammatory disease (PID) for a geographical area in eastern Hungary.


METHODS
Pathogens were identified by culturing or polymerase chain reaction (PCR) from 2215 patients with suspected PID between 1 January 1999 and 31 December 2001. Empiric guidelines for PID treatment were based on susceptibility testing of the recovered bacteria, patient acceptance and cost-effectiveness of drugs and recommendations of earlier studies.


RESULTS
Chlamydia trachomatis was detected in 11%, Neisseria gonorrhoeae in 2%, Streptococcus spp. in 17%, Enterococcus spp. 9%, genital mycoplasmas in 25%, all obligate anaerobic pathogens in 30% of the patients. All antibiotics chosen for our regimen were effective in vitro against one or more recovered pathogens at least in 80%; this regimen produced 98% clinical cure rate in mild cases of PID.


CONCLUSIONS
Early detection and prompt empirical antimicrobial therapy adapted to the local microflora and its resistance pattern can lead to good clinical results.
Department of Obstetrics and Gynecology, Gyula Kenézy County Hospital, Bartók Béla u. 4, H-4043, Debrecen, Hungary.
J
J
Skapinyecz
I
I
Smid
Agnes
A
Juhász
Cs
C
Jeney
F
F
Rozgonyi
P
P
Kovács
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002692:Chlamydia trachomatis / Q000187:drug effects / Q000302:isolation & purification; D016983:Enterococcus / Q000187:drug effects / Q000302:isolation & purification; D005260:Female; D006801:Humans; D006814:Hungary; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009174:Mycoplasma / Q000187:drug effects / Q000302:isolation & purification; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000302:isolation & purification; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy* / Q000382:microbiology*; D010462:Peptostreptococcus / Q000187:drug effects / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D013291:Streptococcus / Q000187:drug effects / Q000302:isolation & purification
D000900:Anti-Bacterial Agents