A whole genome association study in Finnish multiple sclerosis patients with 3669 markers.
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with complex genetic background. In the present study, based in the Finnish population, we typed a large number of microsatellite markers in separately pooled DNA samples from 195 MS patients and 205 controls. A total of 108 markers showed evidence of association. Five genomic regions containing two or more of these markers within a 1-Mb interval were identified, 1q43, 2p16, 4p15, 4q34 and 6p21 (the MHC region). Substantial overlap with previously published linkage genome screens is also seen.
Turku Immunology Center and Department of Virology, University of Turku, Kiinamyllynkatu 13, FIN 20520 Turku, Finland. miklaa@utu.fi
M
M
Laaksonen
A
A
Jonasdottir
R
R
Fossdal
J
J
Ruutiainen
S
S
Sawcer
A
A
Compston
K
K
Benediktsson
T
T
Thorlacius
J
J
Gulcher
J
J
Ilonen
D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D005787:Gene Frequency; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D020161:Physical Chromosome Mapping / Q000706:statistics & numerical data; D016133:Polymerase Chain Reaction / Q000706:statistics & numerical data