Expanding the repertoire of pyrrolidyl PNA analogues for DNA/RNA hybridization selectivity: aminoethylpyrrolidinone PNA (aepone-PNA).
New PNA analogues derived from aminoethylpyrrolidin-5-one backbone show stabilization of aepone-PNA:DNA hybrids and destabilization of the corresponding RNA hybrids compared to unmodified PNA.
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411008, India.
Nagendra K
NK
Sharma
Krishna N
KN
Ganesh
D004247:DNA / Q000737:chemistry*; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D009693:Nucleic Acid Hybridization; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D013696:Temperature
D020135:Peptide Nucleic Acids; D011759:Pyrrolidines; D011760:Pyrrolidinones; D012313:RNA; D004247:DNA