In vitro analysis of the ability of Trichophyton rubrum to become resistant to terbinafine.
In this study, we have investigated in vitro the resistance frequency and development of resistance to terbinafine of Trichophyton rubrum. Results demonstrated that naturally occurring mutants are rare and that T. rubrum appears to have little capacity to develop resistance to terbinafine even after prolonged exposure.
Novartis Research Institute, 1235 Vienna, Austria. colin.osborne@pharma.novartis.com
Colin S
CS
Osborne
Bettina
B
Hofbauer
Bertrand
B
Favre
Neil S
NS
Ryder
D000935:Antifungal Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D003470:Culture Media; D025141:Drug Resistance, Fungal / Q000235:genetics*; D009281:Naphthalenes / Q000494:pharmacology*; D010641:Phenotype; D000077291:Terbinafine; D014249:Trichophyton / Q000187:drug effects* / Q000235:genetics
D000935:Antifungal Agents; D003470:Culture Media; D009281:Naphthalenes; D000077291:Terbinafine