Effects of parathyroidectomy on iron homeostasis and erythropoiesis in hemodialysis patients with severe hyperparathyroidism.
OBJECTIVE
Secondary hyperparathyroidism (HPT) worsens anemia and may cause hyporesponsiveness to recombinant human erythropoietin therapy (r-HuEPO). To investigate the effect of parathyroidectomy (PTX) on iron homeostasis and erythropoiesis, we conducted a prospective study in chronic hemodialysis patients who underwent PTX.


METHODS
Thirty-two patients were enrolled in this study. Based on the increases in hemoglobin level after PTX, patients were divided into responders and nonresponders. Iron homeostasis and erythropoiesis were assessed before and 1 and 3 months after PTX, hemoglobin and parathyroid hormone levels were monitored until 6 months after PTX.


RESULTS
In the responders, increased hemoglobin levels were observed in 15 patients at 1 and 3 months after PTX (8.0 +/- 0.8 g/dl vs. 9.2 +/- 1.3 and 10.1 +/- 0.9 g/dl, p < 0.05). The nonresponders had higher pre-PTX hemoglobin levels than the responders (10.3 +/- 1.6 g/dl vs. 8.0 +/- 0.8 g/dl, p < 0.05). There was no further increase in hemoglobin at 6 months compared to 3 months after PTX in both groups. In neither group did PTX affect serum ferritin, transferrin saturation and serum erythropoietin level. Serum soluble transferrin receptor (sTfR) concentration was found to be higher in responders than in nonresponders (3.32 +/- 1.28 mg/l vs. 1.70 +/- 0.31 mg/l, p < 0.05).


CONCLUSIONS
We conclude that PTX can improve anemia in hemodialysis patients with severe hyperparathyroidism and greater resistance to r-HuEPO therapy. The reversing of anemia does not involve altering iron mobilization. Pre-PTX hemoglobin and serum sTfR levels can predict the effect of PTX on correcting anemia.
Lee
Chien-Te
CT
Division of Nephrology, Department of Internal Medicine, Chang-Gung Memorial Hospital, Kaohsiung, Hsien, Taiwan. ctlee33@adm.cgmh.org.tw
Chou
Fong-Fu
FF
Chang
Hsueh-Wen
HW
Hsu
Yun-Hsuan
YH
Lee
Wen-Chin
WC
Liao
Shang-Chih
SC
Chen
Jin-Bor
JB
D000328:Adult; D000740:Anemia / Q000209:etiology* / Q000628:therapy; D004920:Erythropoiesis; D004921:Erythropoietin / Q000097:blood; D005260:Female; D006706:Homeostasis; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood / Q000601:surgery; D007501:Iron / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016105:Parathyroidectomy; D011446:Prospective Studies; D011990:Receptors, Transferrin / Q000097:blood; D006435:Renal Dialysis
D011990:Receptors, Transferrin; D004921:Erythropoietin; D007501:Iron