Tuning of innate immunity and polarized responses by decoy receptors.
After the identification of the interleukin (IL)-1 type II receptor as the prototype, decoy receptors have been identified for a number of members of the IL-1/IL-18, TNF, IL-10 and IL-13 receptor families. Moreover, the silent receptor D6 is a promiscuous decoy and scavenger receptor of inflammatory chemokines. The IL-1 decoy receptor is regulated by pro- and anti-inflammatory signals and its levels may serve as a readout of the activation of anti-inflammatory pathways, for instance by glucocorticoid hormones. Decoy receptors represent a strategy to tune inflammatory and polarized adaptive responses.
Mantovani
Alberto
A
Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Faculty of Medicine, University of Milan, Milan, Italy. Mantovani@marionegri.it
Bonecchi
Raffaella
R
Martinez
Fernando O
FO
Galliera
Emanuela
E
Perrier
Patrick
P
Allavena
Paola
P
Locati
Massimo
M
D016207:Cytokines / Q000276:immunology; D007113:Immunity, Innate / Q000276:immunology*; D007375:Interleukin-1 / Q000276:immunology*; D019707:Receptors, Chemokine / Q000276:immunology; D017472:Receptors, Interleukin-1 / Q000276:immunology*; D053574:Receptors, Interleukin-1 Type II
D016207:Cytokines; D007375:Interleukin-1; D019707:Receptors, Chemokine; D017472:Receptors, Interleukin-1; D053574:Receptors, Interleukin-1 Type II