Immediate exercise hyperemia in humans is contraction intensity dependent: evidence for rapid vasodilation.
We tested the hypothesis that rapid vasodilation proportional to contraction intensity contributes to the immediate (first cardiac cycle after initial contraction) exercise hyperemia. Ten healthy subjects performed single 1-s isometric forearm contractions at 5, 10, 15, 20, 30, 50, and 70% maximal voluntary contraction intensity (MVC) in arm above heart (AH) and below heart (BH) positions. Forearm blood flow (FBF; brachial artery mean blood velocity, Doppler ultrasound), mean arterial pressure (arterial tonometry), and heart rate (electrocardiogram) were measured beat by beat. Venous emptying (measured with a forearm strain gauge) was already maximized at 5% MVC, indicating that increases in contraction intensity did not further empty the forearm veins. Immediate increases in FBF were linearly proportional to contraction intensity from 5 to 70% MVC in AH (slope = 4.4 +/- 0.5%DeltaFBF/%MVC). In BH, the immediate increase in FBF demonstrated a curvilinear relationship with increasing contraction intensity and was greater than AH at 15, 20, 30, and 50% MVC (P < 0.05). Peak changes in FBF were greater in BH vs. AH from 10 to 50% MVC, even when venous refilling was complete (P < 0.05). These data support the existence of a rapid-acting vasodilatory mechanism(s) at the onset of human forearm exercise.
Department of Physiology, Human Vascular Control Laboratory, School of Physical and Health Education, Queen's University, Kingston, Ontario, Canada K7L 3N6. mt29@post.queensu.ca
M E
ME
Tschakovsky
A M
AM
Rogers
K E
KE
Pyke
N R
NR
Saunders
N
N
Glenn
S J
SJ
Lee
T
T
Weissgerber
E M
EM
Dwyer
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D005260:Female; D005542:Forearm / Q000098:blood supply / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology*; D008297:Male; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000098:blood supply / Q000502:physiology; D014664:Vasodilation / Q000502:physiology*; D014680:Veins / Q000502:physiology