A sense of life: computational and experimental investigations with models of biochemical and evolutionary processes.
We collaborate in a research program aimed at creating a rigorous framework, experimental infrastructure, and computational environment for understanding, experimenting with, manipulating, and modifying a diverse set of fundamental biological processes at multiple scales and spatio-temporal modes. The novelty of our research is based on an approach that (i) requires coevolution of experimental science and theoretical techniques and (ii) exploits a certain universality in biology guided by a parsimonious model of evolutionary mechanisms operating at the genomic level and manifesting at the proteomic, transcriptomic, phylogenic, and other higher levels. Our current program in "systems biology" endeavors to marry large-scale biological experiments with the tools to ponder and reason about large, complex, and subtle natural systems. To achieve this ambitious goal, ideas and concepts are combined from many different fields: biological experimentation, applied mathematical modeling, computational reasoning schemes, and large-scale numerical and symbolic simulations. From a biological viewpoint, the basic issues are many: (i) understanding common and shared structural motifs among biological processes; (ii) modeling biological noise due to interactions among a small number of key molecules or loss of synchrony; (iii) explaining the robustness of these systems in spite of such noise; and (iv) cataloging multistatic behavior and adaptation exhibited by many biological processes.
Department of Computer Science and Mathematics, Courant Institute of Mathematical Sciences, New York University, New York, New York, USA. mishra@nyu.edu
Bud
B
Mishra
Raoul-Sam
RS
Daruwala
Yi
Y
Zhou
Nadia
N
Ugel
Alberto
A
Policriti
Marco
M
Antoniotti
Salvatore
S
Paxia
Marc
M
Rejali
Archisman
A
Rudra
Vera
V
Cherepinsky
Naomi
N
Silver
William
W
Casey
Carla
C
Piazza
Marta
M
Simeoni
Paolo
P
Barbano
Marina
M
Spivak
Jiawu
J
Feng
Ofer
O
Gill
Mysore
M
Venkatesh
Fang
F
Cheng
Bing
B
Sun
Iuliana
I
Ioniata
Thomas
T
Anantharaman
E Jane Albert
EJ
Hubbard
Amir
A
Pnueli
David
D
Harel
Vijay
V
Chandru
Ramesh
R
Hariharan
Michael
M
Wigler
Frank
F
Park
Shih-Chieh
SC
Lin
Yuri
Y
Lazebnik
Franz
F
Winkler
Charles R
CR
Cantor
Alessandra
A
Carbone
Mikhael
M
Gromov
D000818:Animals; D001671:Biochemistry / Q000379:methods; D002477:Cells / Q000166:cytology / Q000378:metabolism; D019295:Computational Biology / Q000379:methods*; D019143:Evolution, Molecular; D006801:Humans; D008954:Models, Biological; D008957:Models, Genetic; D011687:Purines / Q000378:metabolism; D012984:Software; D013597:Systems Analysis
D011687:Purines