LEMS IgG binds to extracellular determinants on N-type voltage-gated calcium channels, but does not reduce VGCC expression.
Department of Neurology, Kanazawa University School of Medicine, Takara-machi, Kanazawa 920-8641, Japan. neuiwasa@med.kanazawa-u.ac.jp
Kazuo
K
Iwasa
Ashwin
A
Pinto
Angela
A
Vincent
Bethan
B
Lang
D001666:Binding Sites, Antibody; D002121:Calcium Channel Blockers / Q000378:metabolism; D020864:Calcium Channels, N-Type / Q000276:immunology / Q000378:metabolism*; D002460:Cell Line; D005110:Extracellular Space / Q000378:metabolism*; D015870:Gene Expression / Q000276:immunology; D006801:Humans; D007456:Iodine Isotopes / Q000378:metabolism; D015624:Lambert-Eaton Myasthenic Syndrome / Q000276:immunology*; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism; D011863:Radioimmunoassay; D014162:Transfection
D002121:Calcium Channel Blockers; D020864:Calcium Channels, N-Type; D007456:Iodine Isotopes; D021122:Protein Subunits