Biodegradable electrospun fibers for drug delivery.
The influences of surfactants and medical drugs on the diameter size and uniformity of electrospun poly(L-lactic acid) (PLLA) fibers were examined by adding various surfactants (cationic, anionic, and nonionic) and typical drugs into the PLLA solution. Significant diameter reduction and uniformity improvement were observed. It was shown that the drugs were capsulated inside of the fibers and the drug release in the presence of proteinase K followed nearly zero-order kinetics due to the degradation of the PLLA fibers. Such ultrafine fiber mats containing drugs may find clinical applications in the future.
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Jing
J
Zeng
Xiaoyi
X
Xu
Xuesi
X
Chen
Qizhi
Q
Liang
Xinchao
X
Bian
Lixin
L
Yang
Xiabin
X
Jing
D001673:Biodegradation, Environmental; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D019286:Endopeptidase K / Q000378:metabolism; D057927:Hydrophobic and Hydrophilic Interactions; D019344:Lactic Acid / Q000737:chemistry* / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D036103:Nanotechnology / Q000379:methods; D017239:Paclitaxel / Q000008:administration & dosage / Q000737:chemistry; D011091:Polyesters; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D012293:Rifampin / Q000008:administration & dosage / Q000737:chemistry; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D055672:Static Electricity; D013501:Surface-Active Agents / Q000737:chemistry
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; D013501:Surface-Active Agents; D019344:Lactic Acid; D012967:Sodium Dodecyl Sulfate; C033616:poly(lactide); D004317:Doxorubicin; D019286:Endopeptidase K; D017239:Paclitaxel; D012293:Rifampin