Regulators of nucleolar functions.
The nucleolus is the ribosome factory and also a multifunctional domain that plays an important role in nuclear organization and function. Interestingly, ribosome biogenesis appears directly related to cell growth and proliferation. The nucleolus corresponds to a very dynamic nuclear domain resulting from an equilibrium between the level of ribosomal RNA synthesis and the efficiency of ribosomal RNA processing. Ribosome biogenesis is regulated throughout interphase and stops during mitosis. The mitotic silencing of transcription, the distribution of the processing machinery, as well as the link between transcription and processing were found to be dependent on cyclin-dependent kinase(s).
Institut Jacques Monod, 2 place Jussieu, 75251 Paris, France.
Danièle
D
Hernandez-Verdun
Pascal
P
Roussel
D000818:Animals; D002453:Cell Cycle / Q000235:genetics*; D002466:Cell Nucleolus / Q000235:genetics*; D018844:Cyclin-Dependent Kinases / Q000235:genetics; D004275:DNA, Ribosomal / Q000235:genetics; D006801:Humans; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D012335:RNA, Ribosomal / Q000096:biosynthesis* / Q000235:genetics; D037941:Silencer Elements, Transcriptional / Q000235:genetics
D004275:DNA, Ribosomal; D011500:Protein Synthesis Inhibitors; D012335:RNA, Ribosomal; D018844:Cyclin-Dependent Kinases