[Notch1 receptor: structure and role during T-cell development].
The Notch family are proteins which function both as cell surface receptors and regulators of gene transcription. Notch proteins influence cell-fate decisions during lymphopoesis, neurogenesis and myogenesis. During lymphopoesis Notch1 is implicated in differentiation of lymphoid precursor CLP towards T-cells bot not B-cells lineage. In spite of earlier results suggesting involvement of Notch1 in commitment towards alpha beta and gamma delta or CD4 and CD8 T cell lineage, later experiments didn't confirm this possibility.
Zakład Immunologii Nowotworów, Laboratorium Immunologii Komórkowej Instytutu Immunologii i Terapii Doświadczalnej PAN.
Barbara
B
Gidzińska
D000818:Animals; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D051880:Receptors, Notch; D013601:T-Lymphocytes / Q000737:chemistry / Q000378:metabolism; D015534:Trans-Activators / Q000737:chemistry / Q000378:metabolism
D008565:Membrane Proteins; D051880:Receptors, Notch; D015534:Trans-Activators