Genetic aspects and genetic epidemiology of parasomnias.
Parasomnias are undesirable phenomena associated with sleep. Many of them run in families, and genetic factors have been long suggested to be involved in their occurrence. This article reviews the present knowledge of the genetics of the major classical behavioral parasomnias as well as present results from genetic epidemiological studies. The level and type of evidence for genetic effects varies much from parasomnia to parasomnia. The genetic factors are best established in enuresis, with several linkages to chromosomal loci, but their functions are not so far known. Environmental causes and gene-environment interactions are most probably also of great importance in the origin of complex traits or disorders such as parasomnias.
Hublin
Christer
C
Haaga Neurological Research Centre Neuro, Mäkipellontie 15, FIN-00320 Helsinki, Finland. christer.hublin@neuro.org
Kaprio
Jaakko
J
D001143:Arousal / Q000502:physiology; D002012:Bruxism / Q000235:genetics; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D004775:Enuresis / Q000235:genetics; D004777:Environment; D006801:Humans; D008967:Molecular Biology / Q000379:methods; D020447:Parasomnias / Q000235:genetics* / Q000503:physiopathology; D012895:Sleep, REM / Q000502:physiology; D018433:Twin Studies as Topic; D014705:Verbal Behavior