[Oncologic risk factors in papillomavirus infection].
Cytological screening is essential for adequate diagnosis of gynecological cancer. Moreover, every effort should be made to identify such risks of cancer as viruses (HPV, Herpes simplex, cytomegalovirus, Epstein-Barr virus, etc.). When high risk HPV-16 and HPV-18 are detected, diagnostic strategies should include assay of blood prolactin and prolactin/TTH ratio. Virus-related tumors and various risk groups may be studied using HPV genotyping detection of high-risk alleles of certain genes. Hence, some HPV gene variants and gene polymorphism can be investigated as potential risk factors in women.
Safronnikova
N R
NR
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, I.P. Pavlov State Medical University, St. Petersburg.
Zaraĭskiĭ
M I
MI
Chukhlovin
A B
AB
D000483:Alleles; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D014644:Genetic Variation; D005833:Genital Neoplasms, Female / Q000097:blood / Q000821:virology*; D005838:Genotype; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000097:blood / Q000150:complications*; D011110:Polymorphism, Genetic; D011388:Prolactin / Q000097:blood; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000097:blood / Q000150:complications*
D004279:DNA, Viral; D011388:Prolactin