Convergent protein synthesis.
Methods for the chemical synthesis of proteins have advanced considerably over the past decade. In many instances, laboratory synthesis can now be considered a viable alternative to ribosomal biosynthesis, especially when custom modifications of a protein are desired; chemical approaches guarantee virtually unlimited and tunable variation of the covalent structure of a polypeptide.
Casi
Giulio
G
Laboratorium für Organische Chemie, Swiss Federal Institute of Technology, ETH-Hönggerberg, CH-8093, Zürich, Switzerland. hilvert@org.chem.ethz.ch
Hilvert
Donald
D
D020650:Combinatorial Chemistry Techniques; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D015202:Protein Engineering / Q000379:methods*; D011506:Proteins / Q000138:chemical synthesis* / Q000737:chemistry; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis / Q000737:chemistry
D010455:Peptides; D011506:Proteins; D011993:Recombinant Fusion Proteins