[Interferon-induced 2',5'-oligoadenylate system: key components and biological functions].
The current data about the 2',5'-oligoadenylate system is reviewed. Its role in interferon signaling and cell metabolism regulation is discussed. The interferon system is known to be characterized by a wide range of biological functions such as antiviral defense, control of cell growth and differentiation, oncogenic stability, apoptosis, immune activation, etc. The biological role of interferon that is the multifunctional cytokine is discussed more in detail. The structure of main components of interferon signal transduction cascade (2',5'-oligoadenylate, 2',5'-oligoadenylate-synthetase and ribonuclease L) is reviewed. The interferon-induced 2',5'-oligoadenylate system is considered as the component of common regulatory system coordinating cell metabolism.
Taras Shevchenko Kyiv National University, Ukraine. imihalik@yahoo.com
I V
IV
Mykhaĭlyk
L I
LI
Ostapchenko
M Ie
MIe
Kucherenko
D015088:2',5'-Oligoadenylate Synthetase / Q000378:metabolism; D000227:Adenine Nucleotides / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D006801:Humans; D007372:Interferons / Q000502:physiology*; D009843:Oligoribonucleotides; D012333:RNA, Messenger / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology*
D000227:Adenine Nucleotides; D009843:Oligoribonucleotides; D012333:RNA, Messenger; C023505:2',5'-oligoadenylate; D007372:Interferons; D015088:2',5'-Oligoadenylate Synthetase