[Results of a prospective randomized investigation [Russia (St.Petersburg)/WHO] to evaluate the significance of self-examination for the early detection of breast cancer].
Indications for puncture or excision biopsy were significantly higher in the study group (7.5%) as compared with control (3.5%) (p < 0.01) in a randomized prospective controlled trial of a comprehensive breast cancer screening (123,748) carried out in the framework of a self-examination education program. In the self-examination group, detection rates were higher both for benign (1.1%) and malignant (0.85%) tumors than in control (0.5% and 0.69%, respectively) (p < 0.05). Early stage (T1NOMO, Tis) distribution difference in the study group and controls was insignificant--23 and 17.6%, respectively. Compliance with the program requirements including monthly or bimonthly self-examination was followed by higher 15-year survival rates (53.2%) in 70-75% as compared with controls(45.8%) (p = 0.05105): yet it did not affect mortality.
Semiglazov
V F
VF
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Manikhas
A G
AG
Moiseenko
V M
VM
Protsenko
S A
SA
Kharikova
R S
RS
Seleznev
I K
IK
Popova
R T
RT
Migmanova
N Sh
NSh
Orlov
A A
AA
Barash
N Iu
NIu
Ivanova
O A
OA
Ivanov
V G
VG
D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000401:mortality*; D016504:Breast Self-Examination; D005260:Female; D006266:Health Education; D006801:Humans; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D015397:Program Evaluation; D011446:Prospective Studies; D012426:Russia / Q000453:epidemiology; D015996:Survival Rate; D014944:World Health Organization