Functional neuroimaging provides evidence of anomalous cerebral laterality in adults with Klinefelter's syndrome.
This study aimed to characterize cerebral perfusion in men with Klinefelter's syndrome, known to present specific deficits in language, using (99m)Tc- hexamethylpropylene-amine-oxime scintigraphy and Talairach normalization. While a perfusion asymmetry toward the left hemisphere was found in controls, perfusion was mostly symmetrical in Klinefelter patients in the upper temporal and lower parietal areas. Scores on verbal tests were inversely correlated with perfusion changes, providing neurobiological substrate of anomalous cerebral laterality.
Department of Nuclear Medicine, Harbor-UCLA Medical Center, Research and Education Institute, Torrance, CA, USA. eitti@wanadoo.fr
Emmanuel
E
Itti
Irene T
IT
Gaw Gonzalo
Kyle B
KB
Boone
Daniel H
DH
Geschwind
Nancy
N
Berman
Anna
A
Pawlikowska-Haddal
Laurent
L
Itti
Fred S
FS
Mishkin
Ronald S
RS
Swerdloff
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000473:pathology; D002560:Cerebrovascular Circulation; D003071:Cognition; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007713:Klinefelter Syndrome / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D009483:Neuropsychological Tests; D011859:Radiography; D015899:Tomography, Emission-Computed, Single-Photon