Stereoinversion of beta- and gamma-substituted alpha-amino acids using a chemo-enzymatic oxidation-reduction procedure.
Both D- and L-beta- and gamma-substituted alpha-amino acids can be interconverted to their respective L- and D- diastereoisomers by treatment with an enantioselective amino acid oxidase and a chemical reducing agent.
Enright
Alexis
A
School of Chemistry, The University of Edinburgh, King's Buildings, West Mains Road, Edinburgh, UK EH9 3JJ.
Alexandre
Francois-Rene
FR
Roff
Geoffrey
G
Fotheringham
Ian G
IG
Dawson
Michael J
MJ
Turner
Nicholas J
NJ
D000594:Amino Acid Oxidoreductases / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D001894:Borohydrides / Q000737:chemistry; D050830:L-Amino Acid Oxidase; D010084:Oxidation-Reduction; D004718:Saccharomycetales / Q000201:enzymology; D013237:Stereoisomerism
D000596:Amino Acids; D001894:Borohydrides; D000594:Amino Acid Oxidoreductases; D050830:L-Amino Acid Oxidase