Comparative study of topical use of vasodilating solutions.
Vasodilating effects of topically applied lignocaine, papaverine, and chlorpromazine were compared in rats, using a PO2 tissue perfusion monitor and histological analysis. The period of vasospasm was significantly shorter with the use of either 10% lignocaine, 2% papaverine, or 0.25% chlorpromazine than with the use of 2% lignocaine. Although our study found that no particular vasodilating agent was more effective than the others, we did find that although lignocaine 2% and 5% might not be able to fully relieve vasospasm, 10% lignocaine, 2% papaverine, or 0.25% chlorpromazine are recommended to relieve vasospasm clinically as they do not injure the arterial wall.
Department of Plastic and Reconstructive Surgery, Fukushima Medical University, Fukushima, Japan.
Kazuki
K
Ueda
Kiyonori
K
Harii
D000287:Administration, Topical; D000818:Animals; D002746:Chlorpromazine / Q000008:administration & dosage; D005260:Female; D008012:Lidocaine / Q000008:administration & dosage; D010208:Papaverine / Q000008:administration & dosage; D014656:Vascular Surgical Procedures; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
D014665:Vasodilator Agents; D008012:Lidocaine; D010208:Papaverine; D002746:Chlorpromazine