The effect of orally administered marbofloxacin on the pharmacokinetics of theophylline.
As certain quinolones can interfere with the metabolism of theophylline by competitive inhibition of the hepatic microsomal cytochrome P450 system, concomitant use of these drugs with theophylline could result in theophylline toxicity. This study investigated the effect of orally administered marbofloxacin (2 and 5 mg/kg each once daily) on steady-state plasma pharmacokinetics of theophylline after concomitant oral administration of a sustained release theophylline preparation in dogs. Marbofloxacin caused some alteration in theophylline metabolism. A 2 mg/kg dose of marbofloxacin did not clearly result in an increased area under the concentration--time curve (AUC) or decreased clearance of theophylline, but at a dose of 5 mg/kg, a statistically significant increase in AUC and a decrease in the total clearance of theophylline was found. The 26% reduction in theophylline clearance is probably not clinically significant in healthy dogs, but for dogs with renal impairment, there might be a chance of theophylline accumulation when dosed concomitantly with marbofloxacin.
Hirt
R A
RA
Clinic of Internal Medicine for Small Animals and Horses, Veterinary University of Vienna, Veterinaerplatz, Austria. reinhard.hirt@vu-wien.ac.at
Teinfalt
M
M
Dederichs
D
D
van den Hoven
R
R
D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology*; D019540:Area Under Curve; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D004285:Dogs / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D024841:Fluoroquinolones; D008297:Male; D015363:Quinolones / Q000008:administration & dosage / Q000494:pharmacology*; D013806:Theophylline / Q000008:administration & dosage / Q000493:pharmacokinetics*
D000890:Anti-Infective Agents; D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D024841:Fluoroquinolones; D015363:Quinolones; C080260:marbofloxacin; D013806:Theophylline