Total synthesis of wedelolactone.
The total synthesis of wedelolactone, a naturally occurring direct inhibitor of IKK complex that can suppress LPS-induced caspase-11 expression, using a convergent synthetic approach, is described. The key steps involved in this synthesis include the palladium-catalyzed Sonogashira reaction and the palladium-catalyzed carbonylative annulation reaction. This approach allows access to diversified analogues of wedelolactone.
Li
Chuang Chuang
CC
Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry, Peking University, Beijing, PR China, 100871.
Xie
Zhi Xiang
ZX
Zhang
Yan Dong
YD
Chen
Jia Hua
JH
Yang
Zhen
Z
D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry; D061945:Caspase Inhibitors; D020169:Caspases / Q000737:chemistry; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology; D047908:Intracellular Signaling Peptides and Proteins; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors; D009682:Magnetic Resonance Spectroscopy; D010165:Palladium / Q000737:chemistry; D013329:Structure-Activity Relationship
D002352:Carrier Proteins; D061945:Caspase Inhibitors; D003374:Coumarins; C491968:Ikbkap protein, mouse; D047908:Intracellular Signaling Peptides and Proteins; D008070:Lipopolysaccharides; C051122:wedelolactone; D010165:Palladium; D020169:Caspases