The first applications of carbene ligands in cross-couplings of alkyl electrophiles: sonogashira reactions of unactivated alkyl bromides and iodides.
A Pd/N-heterocyclic carbene-based catalyst achieves the Sonogashira coupling of an array of functionalized, beta-hydrogen-containing alkyl bromides and iodides under mild conditions. By furnishing the first example of a nonphosphine-based palladium catalyst for cross-coupling unactivated alkyl electrophiles, this study provides an impetus for future efforts at catalyst development that extend beyond phosphine ligands.
Eckhardt
Matthias
M
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Fu
Gregory C
GC
D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry*; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*
D000480:Alkynes; D006842:Hydrocarbons, Brominated; D006847:Hydrocarbons, Iodinated