Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines.
Proinflammatory cytokines mediate the toxic effect of superantigenic staphylococcal exotoxins (SE). Doxycycline inhibited SE-stimulated T-cell proliferation and production of cytokines and chemokines by human peripheral blood mononuclear cells. These results suggest that the antibiotic doxycycline has anti-inflammatory effects and is therapeutically useful for mitigating the pathogenic effects of SE.
Krakauer
Teresa
T
Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702-5011, USA. Teresa.Krakauer@det.amedd.army.mil
Buckley
Marilyn
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents; D001427:Bacterial Toxins / Q000494:pharmacology; D002499:Centrifugation, Density Gradient; D018925:Chemokines / Q000096:biosynthesis*; D016207:Cytokines / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000494:pharmacology*; D004768:Enterotoxins / Q000494:pharmacology; D005098:Exotoxins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D013210:Staphylococcus / Q000187:drug effects / Q000378:metabolism*; D018089:Superantigens / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D001427:Bacterial Toxins; D018925:Chemokines; D016207:Cytokines; D004768:Enterotoxins; D005098:Exotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal; D004318:Doxycycline