Transfusion-related acute lung injury.
Transfusion-related acute lung injury (TRALI) is an uncommon complication of allogeneic blood transfusion manifested typically by shortness of breath, fever, and hypotension. It has been estimated to occur in 0.04% to 0.16% per patient transfused. TRALI has been identified as an important cause of transfusion-related morbidity and mortality. Despite the increasing recognition that TRALI represents an important clinical syndrome, much about the pathogenesis, treatment, and prevention of TRALI is poorly understood or is controversial. In this report, what is known about TRALI is summarized and some of the areas in which knowledge and/or consensus are currently lacking are identified.
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Kathryn E
KE
Webert
Morris A
MA
Blajchman
D001782:Blood Donors; D001803:Blood Transfusion / Q000401:mortality; D006801:Humans; D007111:Immunity, Cellular; D011654:Pulmonary Edema / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D012128:Respiratory Distress Syndrome / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D013577:Syndrome; D065227:Transfusion Reaction