[Classical monoamine oxidase inhibitor: not registered for, but still a place in the treatment of depression].
In the Netherlands monoamine oxidase (MAO) inhibitors are not registered for the treatment of patients with depression. The classical, nonselective MAO inhibitors--phenelzine and tranylcypromine--are effective but their use is associated with interactions (with tyramine in food, sympathicomimetics and serotonine re-uptake inhibitors) and side-effects (hypertension, hypotension, headache, sleep disturbances and neuromuscular symptoms in particular). Therefore, the classical MAO inhibitors are indicated only in depressive disorders that are unresponsive to the first stages of treatment. Taking this selection into account, treatment should be long-term to avoid relapse.
Universitair Medisch Centrum Utrecht, afd. Psychiatrie, Postbus 85.500, 3508 GA Utrecht. w.nolen@azu.nl
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D003866:Depressive Disorder / Q000188:drug therapy*; D004347:Drug Interactions; D018565:Food-Drug Interactions; D006801:Humans; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use*; D009426:Netherlands; D010624:Phenelzine / Q000009:adverse effects / Q000627:therapeutic use; D055502:Secondary Prevention; D013997:Time Factors; D014191:Tranylcypromine / Q000009:adverse effects / Q000627:therapeutic use
D008996:Monoamine Oxidase Inhibitors; D014191:Tranylcypromine; D010624:Phenelzine