In regard to DAI et al.: inhibition of hypoxia inducible factor 1alpha causes oxygen-independent cytotoxicity and induces p53 independent apoptosis in glioblastoma cells. IJROBP 2003;55:1027-1036).
Dirk
D
Vordermark
D001254:Astrocytoma / Q000378:metabolism; D015687:Cell Hypoxia; D045744:Cell Line, Tumor / Q000378:metabolism; D002470:Cell Survival; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005909:Glioblastoma / Q000378:metabolism*; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009363:Neoplasm Proteins / Q000378:metabolism*; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011379:Prognosis; D014157:Transcription Factors
D004268:DNA-Binding Proteins; C497442:HIF1A protein, human; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors