Renal tubular regeneration by bone marrow-derived cells in a girl after bone marrow transplantation.
Recent studies have indicated that bone marrow cells can contribute to regeneration of the kidney in experimental models. However, renal regeneration by apparent bone marrow-derived cells has not been shown previously in humans. The authors here report on a 7-year-old girl who received whole bone marrow transplantation from a male donor, and the contribution of bone marrow cells to the regeneration after renal damage was shown by in situ hybridization for the Y chromosome on autopsy specimens of the kidney. This observation suggests the clinical potential of bone marrow cells as a therapeutic option for renal injury.
Department of Pediatric Cardiology and Nephrology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan. mnishida@koto.kpu-m.ac.jp
Masashi
M
Nishida
Hidekazu
H
Kawakatsu
Isao
I
Shiraishi
Shin-ichiro
S
Fujimoto
Takahiro
T
Gotoh
Yoji
Y
Urata
Takahiko
T
Ono
Kenji
K
Hamaoka
D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D041322:Chromosomes, Human, Y; D020031:Epstein-Barr Virus Infections / Q000150:complications; D017809:Fatal Outcome; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications / Q000188:drug therapy; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007684:Kidney Tubules / Q000502:physiology*; D009102:Multiple Organ Failure / Q000209:etiology; D012038:Regeneration / Q000235:genetics / Q000502:physiology*