[Antibiotic prophylaxis in laparoscopic cholecystectomy: from empiricism to evidence. Review of the problem and proposal of a randomized trial of the Lap Group Roma].
More than 10 years after its appearance in clinical practice, laparoscopic cholecystectomy can now be considered the standard operation for gallstone disease. However, some aspects of this operation are still debated. The need to perform routine antibiotic prophylaxis in order to reduce the incidence of infectious complications is still a matter of controversy. International guidelines do not recommend its routine use. The evidence for this, however, is rather limited, because there are no randomized trials with a sufficient number of cases to avoid a type II error. The authors, on behalf of the Lap Group Roma, introduce the protocol of a multicenter prospective randomized controlled clinical trial designed to find a definitive answer to this problem.
UOC Chirurgia Generale e Oncologica, ACO San Filippo Neri, Via G. Martinotti, 20, 00135 Roma. m.catarci@sanfilipponeri.roma.it
Marco
M
Catarci
Massimo
M
Carlini
Paolo
P
Gentileschi
Emanuele
E
Santoro
Giorgio
G
Pasquini
Gianfranco
G
Silecchia
Giancarlo
G
Ferretti
Raffaele
R
Masciangelo
Stefano
S
Mancini
D019072:Antibiotic Prophylaxis; D017081:Cholecystectomy, Laparoscopic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic