Prenylated xanthones from Garcinia xanthochymus.
A new prenylated xanthone, 1,3,5,6-tetrahydroxy-4,7,8-tri(3-methyl-2-butenyl)xanthone (1), was isolated from the wood of Garcinia xanthochymus together with a known xanthone, garciniaxanthone E (2). Their structures were determined by spectroscopic analysis. Compounds 1 (3 microM) and 2 (10 microM) elicited marked enhancement of nerve growth factor-mediated neurite outgrowth in PC12D cells.
Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
Wisinee
W
Chanmahasathien
Yushan
Y
Li
Masayuki
M
Satake
Yasukatsu
Y
Oshima
Masami
M
Ishibashi
Nijsiri
N
Ruangrungsi
Yasushi
Y
Ohizumi
D000818:Animals; D004357:Drug Synergism; D029760:Garcinia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009414:Nerve Growth Factors / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects; D016716:PC12 Cells; D010936:Plant Extracts / Q000737:chemistry; D017368:Protein Prenylation; D051381:Rats; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014934:Wood; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D009414:Nerve Growth Factors; D010936:Plant Extracts; D044004:Xanthones