Concurrent poststreptococcal glomerulonephritis and autoimmune hemolytic anemia.
We describe three cases of poststreptococcal glomerulonephritis (PSGN) associated with autoimmune hemolytic anemia. Along with the classic findings of PSGN, the patients had a positive direct antiglobulin test. Two patients had a cold-reacting anti-I autoantibody. This is the first description of this association. Autoimmune hemolytic anemia should be considered in children with PSGN and significant anemia or signs of hemolysis.
Greenbaum
Larry A
LA
Department of Pediatrics (Nephrology), Medical College of Wisconsin and Children's Hospital of Wisconsin, Wisconsin 53226, USA. Lgreen@mcw.edu
Kerlin
Bryce A
BA
Van Why
Scott
S
Punzalan
Rowena C
RC
Trost
Beth A
BA
Pan
Cynthia G
CG
Scott
J Paul
JP
D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications*; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005921:Glomerulonephritis / Q000209:etiology*; D006461:Hemolysis; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D013290:Streptococcal Infections / Q000150:complications*
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies