Death receptors.
Death receptors [Fas/Apo-1/CD95, TNF-R1 [tumour necrosis factor (TNF) receptor 1], DR3 [death receptor 3], TRAIL-R1 [TNF-related apoptosis-inducing ligand receptor 1], TRAIL-R2, DR6, p75-NGFR [p75-nerve growth factor receptor], EDAR [ectodermal dysplasia receptor]] form a subgroup of the TNF-R superfamily that can induce apoptosis (programmed cell death) via a conserved cytoplasmic signalling module termed the death domain. Although death receptors have been recognized mainly as apoptosis inducers, there is growing evidence that these receptors also fulfil a variety of nonapoptotic functions. This review is focused on the molecular mechanisms of apoptotic and non-apoptotic death receptor signalling in light of the phenotype of mice deficient in the various death receptors.
Wajant
Harald
H
Department of Molecular Internal Medicine, Medical Polyclinic, University of Wuerzburg, Roentgenring 11, 97 070 Wuerzburg, Germany. harald.wajant@mail.uni-wuerzburg.de
D000818:Animals; D017209:Apoptosis; D053339:Edar Receptor; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism; D053338:Receptors, Ectodysplasin; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D053219:Receptors, Tumor Necrosis Factor, Member 25; D015398:Signal Transduction; D019014:fas Receptor / Q000378:metabolism
C506008:EDAR protein, human; D053339:Edar Receptor; C506009:Edar protein, mouse; D008565:Membrane Proteins; D020800:Receptor, Nerve Growth Factor; D053338:Receptors, Ectodysplasin; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D018124:Receptors, Tumor Necrosis Factor; D053219:Receptors, Tumor Necrosis Factor, Member 25; C105190:TNFRSF10A protein, human; C505639:TNFRSF10B protein, human; C506033:TNFRSF25 protein, human; C505640:Tnfrsf10b protein, mouse; C485251:Tnfrsf21 protein, mouse; C506034:Tnfrsf25 protein, mouse; D019014:fas Receptor