Ran in the spindle checkpoint: a new function for a versatile GTPase.
The small GTPase Ran has a well-established role in nucleocytoplasmic trafficking. In recent years, the repertoire of Ran has expanded to include regulation of spindle assembly, formation of the nuclear envelope and DNA replication. Now, new studies further extend the role of Ran to regulating the spindle checkpoint during mitosis.
Department of Embryology, Carnegie Institution of Washington and Howard Hughes Medical Institute, Johns Hopkins University, 115 West University Parkway, Baltimore, MD 21210, USA.
Hoi-Yeung
HY
Li
Kan
K
Cao
Yixian
Y
Zheng
D000818:Animals; D018797:Cell Cycle Proteins; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D009687:Nuclear Proteins; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000502:physiology*; D014981:Xenopus; D029867:Xenopus Proteins; D020931:ran GTP-Binding Protein / Q000235:genetics / Q000502:physiology*
D018797:Cell Cycle Proteins; D020662:Guanine Nucleotide Exchange Factors; D009687:Nuclear Proteins; C499304:RCC1 protein, Xenopus; D029867:Xenopus Proteins; D020931:ran GTP-Binding Protein