Effect of one week treatment with Ginkgo biloba extract (EGb761) on ischemia-induced infarct volume in gerbils.
The present study was designed to evaluate the neuroprotective effects of Ginkgo biloba leaf extract (EGb761) in male gerbils subjected to focal cerebral ischemia produced by permanent occlusion of the right middle cerebral artery. In this study, gerbils were fed standard chow with or without EGb761 (100 mg/kg/day, i.g.) prior to cerebral ischemia for 1 week. Gerbils were anesthetized and craniectomized to expose the right middle cerebral artery (MCA). The right MCA was constricted with an 8-0 suture to produce a permanent ligation. Infarct volume was assessed by TTC (2,3,5-triphenyl-tetrazolium chloride) staining 24 hours after initiation of cerebral ischemia. Results showed that the EGb761 group had significant reduction of infarct volume 4 and 6 mm from the frontal pole by 40% and 30%, respectively when compared to the control group (p < 0.05). Mean locomotor activity of gerbils was reduced 24 hours after the occlusion of the MCA in both groups. However, there was no difference in locomotor activity between groups either 30 minutes before or 24 hours after the occlusion (p > 0.05).
Chung
Shu-Ying
SY
Department of Food and Nutrition, Providence University 433 Taichung, Taiwan, ROC.
Wang
Ming-Fu
MF
Lin
Jing-Ying
JY
Lin
Ming-Cheng
MC
Liu
Hui-Ming
HM
Cheng
Fu-Chou
FC
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002545:Brain Ischemia / Q000473:pathology / Q000517:prevention & control*; D005849:Gerbillinae; D020441:Ginkgo biloba; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000096983:Ginkgo Extract
D000975:Antioxidants; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract