Biphasic constitutive laws for biological interface evolution.
A model of tissue differentiation at the bone-implant interface is proposed. The basic hypothesis of the model is that the mechanical environment determines the tissue differentiation. The stimulus chosen is related to the bone-implant micromotions. Equations governing the evolution of the interfacial tissue are proposed and combined with a finite element code to determine the evolution of the fibrous tissue around prostheses. The model is applied to the case of an idealized hip prosthesis.
LRO, Bat. AAB, Laboratory of Orthopedic Research, EPFL, 1015 Lausanne, Switzerland. philippe.buechler@epfl.ch
P
P
Büchler
D P
DP
Pioletti
L R
LR
Rakotomanana
D000465:Algorithms; D000818:Animals; D016723:Bone Remodeling; D003198:Computer Simulation; D019544:Equipment Failure Analysis / Q000379:methods*; D005269:Femur / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D005355:Fibrosis / Q000209:etiology / Q000503:physiopathology; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D007593:Joint Instability / Q000209:etiology* / Q000503:physiopathology*; D008954:Models, Biological; D009038:Motion; D011475:Prosthesis Failure; D013314:Stress, Mechanical; D013499:Surface Properties; D016896:Treatment Outcome; D016474:Weight-Bearing