In vitro activity of TD-6424 against Staphylococcus aureus.
TD-6424, a rapidly bactericidal agent with multiple mechanisms of action, is more potent in vitro and more rapidly bactericidal than currently available agents against methicillin-susceptible and methicillin-resistant Staphylococcus aureus. TD-6424 produces a postantibiotic effect with a duration of 4 to 6 h against these organisms. The results suggest potential efficacy against susceptible and resistant strains of S. aureus.
Pace
John L
JL
Theravance, Inc., South San Francisco, California 94080, USA.
Krause
Kevin
K
Johnston
Deborah
D
Debabov
Dmitri
D
Wu
Terry
T
Farrington
Lesley
L
Lane
Cassie
C
Higgins
Deborah L
DL
Christensen
Burt
B
Judice
J Kevin
JK
Kaniga
Koné
K
D000890:Anti-Infective Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects*
D000890:Anti-Infective Agents