[The scientific and clinical value of molecular genetic changes in the intercellular gap junctions observed in colon cancer].
Colon cancer is one of the most widespread pathologies with high mortality due to recurrence and metastasis. The molecular methods of diagnosis, prognostication and biotherapy in colorectal cancer enjoyed a rapid progress during the recent decades. The hypothesis on the key role of impaired intercellular gap junctions in the onset and progression of malignant tumors is a promising trend in carcinogenesis research. We have recently discovered a variety of tumor-specific mutations of connexin 43 gene in advanced colorectal cancer (Oncogene. -2002.-Vol.21, No.32-pp.4992-4996), which confirms the above hypothesis in malignant tumor progression. We believe that further studies of connexins' mutation changes in tumor growth is a promising trend in research of its etiology and pathogenesis and in designing new methods of diagnostics and treatment of colonic and other gastrointestinal cancers.
Iaitskiĭ
N A
NA
Dubina
M V
MV
Vasil'ev
S V
SV
Popov
D E
DE
Krutovskikh
V A
VA
D000230:Adenocarcinoma / Q000175:diagnosis / Q000209:etiology / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D000818:Animals; D002471:Cell Transformation, Neoplastic; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D018031:Connexin 43 / Q000235:genetics*; D005260:Female; D017629:Gap Junctions / Q000235:genetics*; D016147:Genes, Tumor Suppressor; D015316:Genetic Therapy; D042822:Genomic Instability; D006706:Homeostasis; D006801:Humans; D008297:Male; D051379:Mice; D009154:Mutation; D009857:Oncogenes; D011379:Prognosis; D051381:Rats; D012007:Rectum / Q000473:pathology; D014407:Tumor Cells, Cultured
D018031:Connexin 43