Inhibitors of the CDC25 phosphatases.
As essential cell cycle regulators, the CDC25 phosphatases are currently considered as potential targets for the development of novel therapeutic approaches. Here, we review the function and regulation of CDC25 phosphatases, their involvement in cancer and Alzheimer's disease, and the properties of several recently identified inhibitors.
Prevost
Grégoire Pierre
GP
Institut Henri Beaufour, Beaufour-Ipsen, 5 Avenue du Canada, Les Ulis 91966, France.
Brezak
Marie-Christine
MC
Goubin
Françoise
F
Mondesert
Odile
O
Galcera
Marie-Odile
MO
Quaranta
Muriel
M
Alby
Frédéric
F
Lavergne
Olivier
O
Ducommun
Bernard
B
D000544:Alzheimer Disease / Q000188:drug therapy / Q000201:enzymology*; D000818:Animals; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology*; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000639:trends; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology*; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism
D004791:Enzyme Inhibitors; D020687:cdc25 Phosphatases