Dually infected (HSV-1/VZV) single neurons in human trigeminal ganglia.
Human trigeminal ganglia were tested by double fluorescence in situ hybridization for the presence and distribution of herpes simplex virus type 1 (HSV-1) and varicella-zoster virus (VZV) latency. Latency transcripts of both viruses were detected in common areas within the ganglia. Also, a few single neurons were shown to harbor HSV-1 and VZV together.
Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians University, Marchioninistrasse 23, 81377 Munich, Germany. dtheil@brain.nefo.med.uni-muenchen.de
Diethilde
D
Theil
Igor
I
Paripovic
Tobias
T
Derfuss
Simone
S
Herberger
Michael
M
Strupp
Viktor
V
Arbusow
Thomas
T
Brandt
D000293:Adolescent; D000328:Adult; D000368:Aged; D001344:Autopsy; D005260:Female; D006561:Herpes Simplex / Q000821:virology*; D006562:Herpes Zoster / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000302:isolation & purification*; D014645:Herpesvirus 3, Human / Q000302:isolation & purification*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000821:virology; D012668:Trigeminal Ganglion / Q000821:virology*