Hepatic plasma clearance of 99mTc-HEPIDA as a diagnostic tool: theoretical basis for a simplified determination.
The determination of hepatic plasma clearance of( 99m)Tc-HEPI-DA is becoming a clinically attractive test. It is not necessary to perform always the determination using an extensive sampling of blood over the period of 0-90 min post injection of the radiopharmaceutical. For screening purposes a simplified method is adequate, even if less precise of the low values of the clearance. In this paper a theoretical basis has been presented for the development of such a simplified procedure, based on a single plasma sample for determination of the hepatic and urinary clearance of (99m)Tc-HEPIDA.
Department of Nuclear Medicine, Medical University of Łódź, Poland. mjsurma@csk.am.lodz.pl
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