Surgery of the subthalamic nucleus: use of movement-related neuronal activity for surgical navigation.
THE BASAL GANGLIA have important roles in somatic motor, oculomotor, limbic, and associative functions. These functions are represented in anatomically distinct territories in each basal ganglion nucleus. During surgery of the subthalamic nucleus for Parkinson's disease, the primary goal is to influence the physiology of the motor territory without affecting nonmotor areas. This article describes the use of movement-related cellular activity during single-unit microelectrode mapping to identify and to navigate within the motor territory of the subthalamic nucleus.
Starr
Philip A
PA
Department of Neurological Surgery, University of California, San Francisco, California 94143, USA. starrp@itsa.ucsf.edu
Theodosopoulos
Philip V
PV
Turner
Robert
R
D001931:Brain Mapping / Q000379:methods*; D006801:Humans; D009068:Movement / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010300:Parkinson Disease / Q000503:physiopathology / Q000601:surgery; D020531:Subthalamic Nucleus / Q000503:physiopathology* / Q000601:surgery*