Nosocomial Mycobacterium bovis-bacille Calmette-Guérin infections due to contamination of chemotherapeutics: case finding and route of transmission.
We studied nosocomial infections due to Mycobacterium bovis bacille Calmette-Guérin (BCG) Onco-TICE bacteria, transmitted by contamination of medication prepared in BCG Onco-TICE-contaminated hoods in the pharmacy, in 5 immunocompromised patients at 3 hospitals. The BCG strains cultured from the patients had the same DNA profile as the BCG Onco-TICE strain used for bladder instillation. To prevent these infections, a change from open to closed preparation was made; strictly separated preparation in time of BCG Onco-TICE instillation and chemotherapy was enforced, the biological safety cabinet was disinfected between preparations, and gloves were changed between preparations.
Vos
Margreet C
MC
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands. m.vos@erasmusmc.nl.
de Haas
Petra E W
PE
Verbrugh
Henri A
HA
Renders
Nicole H M
NH
Hartwig
Nico G
NG
de Man
Peter
P
Kolk
Arend H J
AH
van Deutekom
Henk
H
Yntema
J L
JL
Vulto
Arnold G
AG
Messemaker
Marja
M
van Soolingen
Dick
D
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001500:BCG Vaccine / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000276:immunology / Q000382:microbiology*; D004340:Drug Contamination; D005260:Female; D006801:Humans; D016867:Immunocompromised Host / Q000187:drug effects / Q000276:immunology; D008297:Male; D009164:Mycobacterium Infections / Q000276:immunology / Q000382:microbiology*; D009163:Mycobacterium bovis / Q000254:growth & development*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D001500:BCG Vaccine