Olanzapine effects on auditory sensory gating in schizophrenia.
OBJECTIVE
New-generation antipsychotics have been proposed to normalize the P50 sensory gating index in patients with schizophrenia. In the context of a double-blind comparison of olanzapine and haloperidol, the authors examined the effect of olanzapine on P50 suppression.


METHODS
P50 measurements were obtained at baseline while patients were being treated with fluphenazine and after 12 weeks of double-blind treatment with either olanzapine (N=12) or haloperidol (N=12).


RESULTS
There were no treatment group differences in P50 amplitude, latency, or sensory gating ratio.


CONCLUSIONS
These results suggest that there is not a significant differential effect of olanzapine and haloperidol on the P50 sensory gating index in schizophrenia.
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland, Baltimore, MD 21228, USA.
Celso
C
Arango
Ann
A
Summerfelt
Robert W
RW
Buchanan
D000161:Acoustic Stimulation; D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001307:Auditory Perception / Q000187:drug effects; D001569:Benzodiazepines; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use*; D013216:Reflex, Startle / Q000187:drug effects*; D012559:Schizophrenia / Q000188:drug therapy*
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D006220:Haloperidol; D000077152:Olanzapine