Nosocomial superinfections due to linezolid-resistant Enterococcus faecalis: evidence for a gene dosage effect on linezolid MICs.
Resistance to linezolid among Enterococcus faecium and Enterococcus faecalis isolates has been reported in patients who receive a prolonged course of the drug. We report two cases of linezolid-resistant Enterococcus faecalis that occurred in patients who previously received linezolid for infections with vancomycin-resistant Enterococcus faecium. Both isolates had the G2576U mutation in the 23S rRNA previously reported in isolates of Enterococcus faecium. The number of gene copies mutated in the 23S rRNA correlated with the level of resistance.
University of Illinois at Chicago, Department of Internal Medicine, Section of Infectious Disease, 808 S. Wood St., Rm 888, M/C 735, Chicago, IL 60612, USA.
Kathleen A
KA
Ruggero
Laura K
LK
Schroeder
Paul C
PC
Schreckenberger
Alexander S
AS
Mankin
John P
JP
Quinn
D000081:Acetamides / Q000008:administration & dosage / Q000494:pharmacology*; D000368:Aged; D001483:Base Sequence; D003428:Cross Infection / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D004305:Dose-Response Relationship, Drug; D004352:Drug Resistance, Microbial; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000235:genetics; D005798:Genes, Bacterial / Q000235:genetics; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy*; D006760:Hospitalization; D006801:Humans; D000069349:Linezolid; D008297:Male; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D023303:Oxazolidinones / Q000008:administration & dosage / Q000494:pharmacology*; D016133:Polymerase Chain Reaction; D020521:Stroke / Q000150:complications* / Q000175:diagnosis
D000081:Acetamides; D023303:Oxazolidinones; D000069349:Linezolid