Acute akinesia or akinetic crisis in Parkinson's disease.
In 22 patients with idiopathic Parkinson's disease we observed a sudden worsening of motor symptoms and severe akinesia during hospitalization because of infectious diseases, bone fractures, surgery for gastrointestinal tract diseases, and iatrogenic causes. Of these patients, 12 recovered completely, 6 had a partial recovery, and 4 died. Treatments included subcutaneous apomorphine/lisuride infusion and dantreolene (with a creatine phosphokinase level higher than 200 IU). In all patients a definite refractoriness to therapy was shown with a transient lack of response to apomorphine.
Department of Neurophysiopathology, Movement Disorder Center, Department of Oncology and Neuroscience, University G. D'Annunzio, Chieti-Pescara, Italy.
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Thomas
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Iacono
A L
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Luciano
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Armellino
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Onofrj
D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D016022:Case-Control Studies; D003428:Cross Infection / Q000150:complications / Q000188:drug therapy; D003620:Dantrolene / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009069:Movement Disorders / Q000145:classification / Q000188:drug therapy / Q000209:etiology*; D009125:Muscle Relaxants, Central / Q000627:therapeutic use; D017063:Outcome Assessment, Health Care; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy
D000978:Antiparkinson Agents; D009125:Muscle Relaxants, Central; D003620:Dantrolene