Highly enantioselective additions of diethylzinc to aldehydes using 2-triflamido-methyl-2'-hydroxy-1,1'- binaphthyl.
[reaction: see text] A new N-triflated amino alcohol-titanium catalyst was designed for the asymmetric ethylation of aldehydes. This binaphthyl-based sulfonamido alcohol ligand shows uniformly high yield and enantioselectivity in the diethylzinc additions of aromatic, aliphatic, and unsaturated aldehydes.
Department of Chemistry, Korea University, Seoul 136-701, Korea.
Seung-Wan
SW
Kang
Dong-Hyun
DH
Ko
Kyoung Hoon
KH
Kim
Deok-Chan
DC
Ha