Birth and evolutionary history of a human minisatellite.
One of the most exciting challenges in human biology is the understanding of how our genome was constructed during evolution. Here we explore the evolutionary history of the low polymorphic human minisatellite MsH42 and its flanking sequences. We show that the evolutionary birth of MsH42 took place within an intron, early in primate lineage evolution, more than 40 MYA. Then, single base-pair changes and duplications/deletions of repeat blocks by mispairing were probably the main forces governing the generation of this minisatellite and its polymorphism throughout primate evolution. Moreover, we detected several phylogenetic footprints at both sides of MsH42. We believe that our findings will contribute to the understanding of low-variability minisatellite evolution.
Departamento de Bioquímica y Biología Molecular, Facultad de Biología, Universidad de Santiago, Galicia, Spain. bnjgm@usc.es
Francisco
F
Boán
Miguel G
MG
Blanco
Javier
J
Quinteiro
Susana
S
Mouriño
Jaime
J
Gómez-Márquez
D000818:Animals; D001483:Base Sequence; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics*; D019143:Evolution, Molecular; D015894:Genome, Human; D000882:Haplorhini; D006801:Humans; D007438:Introns / Q000235:genetics*; D018598:Minisatellite Repeats / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics; D011110:Polymorphism, Genetic; D012689:Sequence Homology, Nucleic Acid