[Biological and toxic effects of ethanol: diagnostics and treatment of acute poisonings].
Ethyl alcohol (ethanol) is readily absorbed from all parts of the gastrointestinal tract due to its hydrophilic potential. The biological effects in humans refer to practically every organ and system. The basic enzyme involved in its oxidation is alcohol dehydrogenase. Another important metabolic pathway is the Microsomal Ethanol-Oxidizing System (MEOS). Toxic effect on basic cell functions is produced both by ethanol and acetic aldehyde, its oxidation product which accounts for most of the acute and delayed effects of ethanol toxicity. In acute ethanol intoxication's the CNS symptoms are the first to manifest. Ethanol affects the CNS functions mainly through stimulating opiate and benzodiazepine receptors and a number of neurotransmitters. However, the attempts to diminish the toxic effects of ethanol on CNS by blocking the affected receptors have proved to be ineffective. In acute poisoning a basic essential is to sustain vital functions by following the principles of intensive care. Each case of acute ethanol intoxication must be subject to neurological examination for possible cerebro-cranial traumas. The diagnostics and treatment procedures should take account of the possible symptoms: convulsions, respiratory and cardiac failure, hypoglycemia, hypothermia, and severe gastric dysfunction. Vital signs monitoring and control of acid-base and water-electrolyte balance are a must. The toxic properties of ethanol metabolites can be particularly hazardous to patients treated with disulfiram. The patients who develop "antabuse response" should be given immediately iron and vitamin C intravenously.
Klinika Ostrych Zatruć Instytutu Medycyny Pracy im. prof. J. Nofera ul. Sw. Teresy od Dzieciatka Jezus 8 90-950 Łódź, skr. pocztowa 199.
Zbigniew
Z
Kołaciński
Piotr
P
Rusiński
D000208:Acute Disease; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D000431:Ethanol / Q000494:pharmacology* / Q000506:poisoning*; D006801:Humans; D007275:Injections, Intravenous; D007501:Iron / Q000008:administration & dosage / Q000627:therapeutic use*; D011041:Poisoning / Q000175:diagnosis / Q000188:drug therapy
D000431:Ethanol; D007501:Iron; D001205:Ascorbic Acid