Do macrophage innate immune receptors enhance atherogenesis?
Macrophages play a central role in both innate immunity to infection and atherosclerosis. Castrillo and colleagues report that selected microbial agonists for Toll-like receptors strongly inhibit LXR-mediated cholesterol efflux from macrophages. TLR-LXR crosstalk could explain how nonspecific microbial infections promote atherogenesis.
Gordon
Siamon
S
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, England.
D000818:Animals; D001161:Arteriosclerosis / Q000276:immunology; D002784:Cholesterol / Q000378:metabolism; D004268:DNA-Binding Proteins; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology / Q000503:physiopathology*; D000071518:Liver X Receptors; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000819:agonists / Q000378:metabolism*; D057093:Orphan Nuclear Receptors; D011956:Receptors, Cell Surface / Q000819:agonists / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists / Q000378:metabolism*; D051193:Toll-Like Receptors
D004268:DNA-Binding Proteins; D000071518:Liver X Receptors; D008562:Membrane Glycoproteins; D057093:Orphan Nuclear Receptors; D011956:Receptors, Cell Surface; D018160:Receptors, Cytoplasmic and Nuclear; D051193:Toll-Like Receptors; D002784:Cholesterol