Methylation: a second hit in the two-hit hypothesis.
This case illustrates that methylation of one BRCA1 allele may serve as the second hit in a patient with a diploid locus and missense mutation on the other allele.
Geisler
J P
JP
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
Rathe
J A
JA
Manahan
K J
KJ
Geisler
H E
HE
D000483:Alleles; D002277:Carcinoma / Q000235:genetics*; D019175:DNA Methylation; D005260:Female; D020868:Gene Silencing; D019398:Genes, BRCA1; D006801:Humans; D020125:Mutation, Missense; D010051:Ovarian Neoplasms / Q000235:genetics*; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational