Evaluation of the safety of ivermectin-praziquantel administered orally to pregnant mares.
OBJECTIVE
To evaluate the safety of an orally administered ivermectin and praziquantel paste with regard to variables associated with clinical findings, parturition, lactation, maternal care, and neonate viability in pregnant mares.


METHODS
40 pregnant mares.


METHODS
Mares were randomly allocated into treatment (n = 20) and control (20) groups and administered a placebo or 3 times the therapeutic dosage of ivermectin (0.6 mg/kg) and praziquantel (4.5 mg/kg) at 14-day intervals until parturition. Physical examinations were performed on mares and their foals after parturition (on postpartum days 30, 60, and 90) to identify any drug-related effects. As an aid in assessing general health, hematologic and serum biochemical analyses were performed monthly on the mares.


RESULTS
In blood constituents, minor alterations that were not biologically important were observed. Reproductive performance was not affected by the unusual treatment duration or high dosage, although the drugs were administered during a crucial period of equine embryonic development (30 to 60 days). Neither adverse effects on mares nor abortions occurred. Follow-up evaluations of the foals for a 3-month period did not detect any abnormalities.


CONCLUSIONS
Administration of the ivermectin-praziquantel paste appears to be safe in pregnant mares and their foals.
Mercier
Patrick
P
Medical Department, Virbac (SA) Laboratories, 06511 Carros Cedex, France.
Alves-Branco
Francisco
F
Sapper
Maria de Fatima
Mde F
White
Christopher Roger
CR
D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006736:Horses; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects* / Q000502:physiology; D012449:Safety
D000871:Anthelmintics; D004338:Drug Combinations; D011223:Praziquantel; D007559:Ivermectin