The relevance of cell size on ultrasound-induced hemolysis in mouse and human blood in vitro.
This paper describes a further test of the hypothesis that cell size is an important physical parameter in ultrasound (US)-induced hemolysis, that is, the larger the cell the greater the potential for sonolysis by a cavitational mechanism. Mouse (M) and human (Hu) erythrocytes in vitro were used; their mean corpuscular volumes were 49.0 and 89.5 fL, respectively. At a US exposure in vitro in the presence of Albunex that yielded an average of 36.8% hemolysis for M blood, the Hu blood yielded an average of 54.0% hemolysis. The data supported the hypothesis. This paper also briefly discusses the difficulty of extrapolating sonolytic in vitro results to those derived in vivo.
Miller
Morton W
MW
Department of Obstetrics and Gynecology, School of Medicine and Dentistry, The University of Rochester, Rochester, NY 14642-0001, USA. Morton_Miller@urmc.rochester.edu
Battaglia
Linda F
LF
D000818:Animals; D048429:Cell Size; D003287:Contrast Media; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000166:cytology* / Q000502:physiology; D006461:Hemolysis; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D013045:Species Specificity; D014463:Ultrasonography
D003287:Contrast Media