Effect of apolipoprotein E alleles and angiotensin-converting enzyme insertion/deletion polymorphisms on lipid and lipoprotein markers in middle-aged men and in patients with stable angina pectoris or healed myocardial infarction.
The effects of the apolipoprotein E epsilon and angiotensin-converting enzyme insertion/deletion alleles on lipid levels and hypolipidemic drug treatment was assessed in 400 men with stable angina pectoris or healed myocardial infarction and 338 healthy controls. The data indicate that epsilon4 carriers have increased total and low-density lipoprotein cholesterol levels, that the epsilon4 allele unfavorably decreases the efficiency of statin treatment, and that the angiotensin-converting enzyme insertion/deletion polymorphism exerts no significant effect, with the exception of an increase in apolipoprotein E levels.
INSERM U558, Faculté de Médecine Purpan, Toulouse, France.
Pedro
P
Marques-Vidal
Vanina
V
Bongard
Jean-Bernard
JB
Ruidavets
Josette
J
Fauvel
Bertrand
B
Perret
Jean
J
Ferrières
D000328:Adult; D000483:Alleles; D000787:Angina Pectoris / Q000097:blood* / Q000235:genetics / Q000628:therapy; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000235:genetics / Q000628:therapy; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000235:genetics / Q000628:therapy; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
D001057:Apolipoproteins E; D008074:Lipoproteins; D007703:Peptidyl-Dipeptidase A