Splenic embolization in a Jehovah's Witness: role of recombinant human factor VIIa.
A case of a 50-year-old Jehovah's Witness with cryptogenic cirrhosis, severe portal hypertension and a coagulopathy, who underwent splenic embolization to improve the platelet count after receiving recombinant human Factor VIIa, is reported. Following the infusion of recombinant human Factor VIIa, the coagulopathy was rapidly corrected and it became possible to safely embolize her spleen. The changes in prothrombin time, international normalized ratio and activated partial thromboplastin time as well as thrombomodulin, tissue factor and plasminogen activator inhibitor after the infusion are presented. As a result of the splenic embolization, her platelet count normalized and she has been listed for liver transplantation.
Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Loyola University Medical Center, Chicago, Stritch School of Medicine, Maywood, IL, USA.
Ayse L
AL
Mindikoglu
Abhinandana
A
Anantharaju
Magdalene
M
George
Nancy
N
Leone
Judy
J
Bejna
David H
DH
Van Thiel
D001778:Blood Coagulation Disorders / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D004621:Embolization, Therapeutic; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D033221:Jehovah's Witnesses; D008103:Liver Cirrhosis / Q000150:complications; D008875:Middle Aged; D010976:Platelet Count; D011994:Recombinant Proteins / Q000627:therapeutic use; D013157:Splenic Artery
D011994:Recombinant Proteins; D015942:Factor VIIa