Better late than never for repair of miscoding lesions within a transcribed template.
Transcription does not always stall at base damage in DNA and can create mutated transcripts from miscoding lesions. In this issue of Molecular Cell, present genetic analysis of E. coli to indicate that the highly mutagenic purine modification, 8-oxoguanine, is subject to transcription-coupled repair despite transcriptional bypass and generation of mutant transcripts.
Seeberg
Erling
E
Centre of Molecular Biology and Neuroscience and Department of Molecular Biology, Institute of Medical Microbiology, University of Oslo, The National Hospital, 0027 Oslo, , Norway.
Klungland
Arne
A
D000818:Animals; D018389:Codon, Nonsense / Q000235:genetics*; D004249:DNA Damage / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D005809:Genes, Regulator / Q000235:genetics*; D006147:Guanine / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D009154:Mutation / Q000235:genetics
D018389:Codon, Nonsense; C024829:8-hydroxyguanine; D006147:Guanine