A genome-wide screen for linkage disequilibrium in Sardinian multiple sclerosis.
Using indirect whole genome association screening, we have searched for multiple sclerosis susceptibility genes in the genetically isolated high risk Sardinian population. Two screens were performed; the first was based on 229 cases and 264 unrelated controls, and the second on 235 trio families. Each screen employed a dense set of microsatellite markers and DNA pooling. Data from both screens were available from 2764 markers. Nine markers showed nominally significant results in both screens independently. Five of these markers-D2S408 (2q36), D6S271 (6p21), D6S344 (6p25), D7S1818 (7p12) and D16S420 (16p12)-remained nominally significant in both studies after conservative refining analysis.
Neurology Unit, Addenbrooks Hospital, University of Cambridge, Hills Road, Cambridge CB2 2QQ, UK.
Francesca
F
Coraddu
Marina
M
Lai
Cristina
C
Mancosu
Eleonora
E
Cocco
Stephen
S
Sawcer
Efrosini
E
Setakis
Alastair
A
Compston
Maria Giovanna
MG
Marrosu
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005189:False Positive Reactions; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods / Q000706:statistics & numerical data; D005828:Genetics, Population; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D007391:International Cooperation; D007558:Italy / Q000453:epidemiology; D015810:Linkage Disequilibrium / Q000235:genetics*; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*