Endothelin-1 concentrations in pericardial fluid are more elevated in patients with ischemic heart disease than in patients with nonischemic heart disease.
There is epidemiologic evidence that the prognosis of patients with nonischemic heart failure is better than that for patients with ischemic heart failure. In addition, studies have revealed that patients with ischemic heart failure show a poorer response to medical therapy. However, the pathophysiologic difference between ischemic and nonischemic heart disease is unclear. To clarify this point, we measured atrial natriuretic peptide, brain natriuretic peptide, angiotensin II, endothelin (ET)-1. interleukin-1beta interleukin-6. tumor necrosis factor (TNF)-alpha soluble TNF receptor I, and soluble TNF receptor II concentrations in plasma and pericardial fluid in patients with ischemic or nonischemic heart disease undergoing cardiac surgery. The pericardial ET-1 concentration in patients with ischemic heart disease was statistically greater than that in patients with nonischemic heart disease (about 1.5-fold), although no difference was found in the plasma ET-1 concentration. These findings suggest that the production and secretion of ET-1 from the myocardium in patients with ischemic heart disease are augmented to a greater extent than in patients with nonischemic heart disease. This result may lead to a greater understanding of the pathophysiology of ischemic heart disease.
Third Department of Internal Medicine, Toho University School of Medicine, Ohashi Hospital, Tokyo, Japan.
Atsushi
A
Namiki
Tetsuya
T
Kubota
Masayuki
M
Fukazawa
Michiro
M
Ishikawa
Masao
M
Moroi
Jo
J
Aikawa
Kunio
K
Ebine
Tetsu
T
Yamaguchi
D000804:Angiotensin II / Q000378:metabolism; D009320:Atrial Natriuretic Factor / Q000032:analysis / Q000378:metabolism; D019332:Endothelin-1 / Q000032:analysis* / Q000097:blood; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism; D020097:Natriuretic Peptide, Brain / Q000378:metabolism; D010490:Pericardial Effusion / Q000737:chemistry*; D011379:Prognosis; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism
D019332:Endothelin-1; D006133:Growth Substances; D018124:Receptors, Tumor Necrosis Factor; D000804:Angiotensin II; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor