Nuclear hormone receptor co-regulators.
The critical role of nuclear hormone receptor co-activators in gene expression has been extensively studied for the past few years. Co-regulators (co-activators and co-repressors) are known to utilize various enzymatic activities, in addition to molecular interactions, to modulate gene expression in response to hormonal signals. Recent studies that demonstrate the role of co-regulators in cancer and developmental disorders have revealed their possible role as targets of therapy. A greater understanding of the cellular physiology of co-regulators is necessary to explore the pathological ramifications of hormone-dependent diseases, and to discover new treatments.
Creighton University, CUMC-Cancer Center, Criss-II, Room 515, 2500 California Plaza, Omaha, NE 68178, USA.
Obaid Yusuf
OY
Khan
Zafar
Z
Nawaz
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology
D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors