Kawasaki disease resistant to immunoglobulin G therapy.
We describe a 3-year-old boy with Kawasaki disease who, despite therapy with two doses of intravenous immunoglobulin G and high-dose aspirin, developed myocarditis in the 1st week of illness and coronary artery aneurysms in the 2nd week. He required a short course of systemic corticosteroids for remission of the illness. The myocarditis subsided and coronary aneurysms remained static and uncomplicated during 6 weeks of follow-up. The diagnosis and recent trends in management of this not uncommon vasculitic disorder are outlined.
Department of Child Health, Sultan Qaboos University Hospital, Muscat, Sultanate of Oman. gopalax@omantel.net.om
P
P
Venugopalan
S
S
Jaya
M A H
MA
Al-Azri
E
E
Piopongco
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002675:Child, Preschool; D003323:Coronary Aneurysm / Q000188:drug therapy / Q000209:etiology; D003937:Diagnosis, Differential; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D009205:Myocarditis / Q000188:drug therapy / Q000209:etiology; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D007074:Immunoglobulin G