Chromosomal translocation in mesenchymal hamartoma of liver: what is its significance?
Mesenchymal hamartoma of the liver is generally considered to be benign in nature, and surgical excision has been the treatment of choice. There have been 3 reports on the association of cytogenetic abnormalities with this tumor, and the possibility of malignant potential has been raised. The authors report a fourth case with a previously unreported complex chromosomal translocation between chromosomes 11, 17, and 19 at bands q12, p11, and q13.3, respectively in all cells examined and discuss the significance of this finding.
Murthi
G V S
GV
Department of Surgical Paediatrics, Royal Hospital for Sick Children, Glasgow, Scotland, UK.
Paterson
L
L
Azmy
A
A
D006222:Hamartoma / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D006801:Humans; D007223:Infant; D008107:Liver Diseases / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D008297:Male; D014178:Translocation, Genetic