[Reperfusion syndrome after direct myocardial revascularization on beating heart in patients with ischemic heart disease. Possibilities of prevention with amlodipine].
Possibilities of secondary prevention of reperfusion syndrome with amlodipine was assessed in 46 patients (39 with class III-IV angina after myocardial infarction and 7 with non ST elevation acute coronary syndrome). Twenty six patients received basic therapy, in 20 patients this therapy was supplemented with amlodipine (5-10 mg/day). In all patients complete direct arterial myocardial revascularization on beating heart was carried out. Methods of dynamic control included echocardiography, paired bicycle exercise tests, 6 minute walk test, myocardial scintigraphy with thallium-199. The results evidence for efficacy and feasibility of secondary prevention of reversible myocardial dysfunction with amlodipine.
Research Insitute of Cardiology of the Research Centre of RAMS Siberian Branch, ul. Kievskaya 111, 634012 Tomsk, Russia.
A T
AT
Tepliakov
G K
GK
Dzhavadova
Sh D
ShD
Akhmedov
M L
ML
Kandinskiĭ
Zh V
ZhV
Vesnina
D000328:Adult; D000368:Aged; D017311:Amlodipine / Q000008:administration & dosage / Q000627:therapeutic use*; D000787:Angina Pectoris / Q000601:surgery; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000601:surgery; D017202:Myocardial Ischemia / Q000601:surgery*; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009204:Myocardial Revascularization; D011182:Postoperative Care; D011300:Preoperative Care; D011877:Radionuclide Imaging; D013577:Syndrome; D013997:Time Factors; D016896:Treatment Outcome; D018616:Ultrasonography, Doppler, Duplex
D002121:Calcium Channel Blockers; D017311:Amlodipine