Prolonged modification of action potential shape by synaptic inputs in molluscan neurones.
1. Somatic action potentials of Lymnaea neurons are modified by excitatory or inhibitory synaptic inputs and have been studied using phase-plane techniques and an action potential duration monitor. 2. Excitatory synaptic inputs increase the rate of neuronal discharge, cause action potential broadening, a decrease in the maximum rate of depolarization (Vd) and a decrease in the maximum rate of repolarization (Vr). 3. Inhibitory synaptic inputs decrease the discharge rate and cause narrowing of action potentials, an increase in Vd and an increase in Vr. 4. The effects reported above outlast the original synaptic inputs by many seconds and, if the somatic action potentials are similar to those in the axon terminals, they may have far-reaching effects on transmitter release.
Department of Physiology, University of Leeds, Leeds LS2 9JT, UK.
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Winlow
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D008195:Lymnaea; D009474:Neurons / Q000502:physiology*; D013569:Synapses / Q000502:physiology*