Ras GTPases: integrins' friends or foes?
Integrins are cell-surface receptors that mediate and coordinate cellular responses to the extracellular matrix (ECM). Cellular signalling pathways can regulate cell adhesion by altering the affinity and avidity of integrins for ECM. The Ras family of small G proteins, which includes H-ras, R-ras and Rap, are important elements in cellular signalling pathways that control integrin function.
Kinbara
Kayoko
K
Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
Goldfinger
Lawrence E
LE
Hansen
Malene
M
Chou
Fan-Li
FL
Ginsberg
Mark H
MH
D000818:Animals; D004789:Enzyme Activation; D005109:Extracellular Matrix / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D020668:rap GTP-Binding Proteins / Q000378:metabolism; D020703:ras GTPase-Activating Proteins / Q000378:metabolism*
D016023:Integrins; D020703:ras GTPase-Activating Proteins; D020668:rap GTP-Binding Proteins