Comparative effect of physiological levels of leptin and insulin on cyclic AMP-induced stimulation of hepatic glycogen breakdown.
Physiological level of insulin showed more prominent inhibiting effect on the activation of hepatic glucose production and glycogenolysis promoted by cAMP than physiological levels of leptin.
Vardanega-Peicher
Márcia
M
Department of Pharmacy and Pharmacology, University of Maringá, 87020-900 Maringá, PR, Brasil. rbbazotte@uem.br
Curi
Rue
R
Souza
Helenir M
HM
Borba-Murad
Glaucia R
GR
Siqueira
V L D
VL
Galende
Sharize
S
Bazotte
Roberto B
RB
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism* / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism* / Q000494:pharmacology; D020738:Leptin / Q000378:metabolism* / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D007328:Insulin; D020738:Leptin; D015124:8-Bromo Cyclic Adenosine Monophosphate; D006003:Glycogen; D000242:Cyclic AMP; D005947:Glucose