Intracellular cargo delivery using tat peptide and derivatives.
Efficient delivery of therapeutic and diagnostic agents across the plasma membrane is crucial in developing novel therapies. Membrane permeating peptides, in particular HIV-1 tat peptide and its derivatives, have enabled the intracellular delivery of cargos of various sizes and physicochemical properties. This review summarizes the current knowledge of tat-derived cell permeating peptides in the transduction of exogenous molecules/complexes.
Zhao
Ming
M
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Rm 5404, Bldg 149, 13th St. Charlestown, Massachusetts 02129, USA.
Weissleder
Ralph
R
D000818:Animals; D001693:Biological Transport, Active / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D002463:Cell Membrane Permeability; D016503:Drug Delivery Systems; D015696:Gene Products, tat / Q000378:metabolism*; D006801:Humans; D009696:Nucleic Acids / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism*; D021381:Protein Transport / Q000502:physiology*; D054322:tat Gene Products, Human Immunodeficiency Virus
D015696:Gene Products, tat; D009696:Nucleic Acids; D010446:Peptide Fragments; D054322:tat Gene Products, Human Immunodeficiency Virus; C422951:tat peptide (48-60), Human immunodeficiency virus 1