Complex segregation analysis of 1,792 cleft lip and palate families in South America: 1967-1997.
Although several studies have demonstrated familial aggregation of nonsyndromic cleft lip with or without cleft palate (CL/P), its model of inheritance remains uncertain. We report the results of complex segregation analysis performed in South American families with a newborn affected with CL/P. Families of 1,792 consecutive newborns affected with CL/P and registered during the period 1967 to 1997 were studied. A model that did not include a major locus was the best-fitting model for CL/P families. This result is in agreement with previous studies which showed a significant association of several putative susceptibility loci and CL/P, indicating that the genes involved in CL/P are likely to have only a very modest impact on disease risk.
Department of Pediatrics, University of Iowa, USA.
Alexandre Rezende
AR
Vieira
Paul Anthony
PA
Romitti
Iêda Maria
IM
Orioli
Eduardo Enrique
EE
Castilla
D002971:Cleft Lip / Q000453:epidemiology / Q000235:genetics*; D002972:Cleft Palate / Q000453:epidemiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D020412:Multifactorial Inheritance; D013020:South America / Q000453:epidemiology