The thioredoxin system--from science to clinic.
The thioredoxin system-formed by thioredoxin reductase and its characteristic substrate thioredoxin-is an important constituent of the intracellular redox milieu. Interactions with many different metabolic pathways such as DNA-synthesis, selenium metabolism, and the antioxidative network as well as significant species differences render this system an attractive target for chemotherapeutic approaches in many fields of medicine-ranging from infectious diseases to cancer therapy. In this review we will present and evaluate the preclinical and clinical results available today. Current trends in drug development are emphasized.
Gromer
Stephan
S
Biochemie-Zentrum Heidelberg, Im Neuenheimer Feld 504, D-69120 Heidelberg, Germany. Stephan@gromer-online.de
Urig
Sabine
S
Becker
Katja
K
D000595:Amino Acid Sequence; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000378:metabolism; D009928:Organ Specificity; D010084:Oxidation-Reduction; D013379:Substrate Specificity; D013880:Thioredoxin-Disulfide Reductase / Q000037:antagonists & inhibitors / Q000145:classification / Q000378:metabolism*; D013879:Thioredoxins / Q000037:antagonists & inhibitors / Q000145:classification / Q000378:metabolism*
D000975:Antioxidants; D013879:Thioredoxins; D013880:Thioredoxin-Disulfide Reductase