The thioredoxin system--from science to clinic.
The thioredoxin system-formed by thioredoxin reductase and its characteristic substrate thioredoxin-is an important constituent of the intracellular redox milieu. Interactions with many different metabolic pathways such as DNA-synthesis, selenium metabolism, and the antioxidative network as well as significant species differences render this system an attractive target for chemotherapeutic approaches in many fields of medicine-ranging from infectious diseases to cancer therapy. In this review we will present and evaluate the preclinical and clinical results available today. Current trends in drug development are emphasized.
Biochemie-Zentrum Heidelberg, Im Neuenheimer Feld 504, D-69120 Heidelberg, Germany. Stephan@gromer-online.de
Stephan
S
Gromer
Sabine
S
Urig
Katja
K
Becker
D000595:Amino Acid Sequence; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000378:metabolism; D009928:Organ Specificity; D010084:Oxidation-Reduction; D013379:Substrate Specificity; D013880:Thioredoxin-Disulfide Reductase / Q000037:antagonists & inhibitors / Q000145:classification / Q000378:metabolism*; D013879:Thioredoxins / Q000037:antagonists & inhibitors / Q000145:classification / Q000378:metabolism*
D000975:Antioxidants; D013879:Thioredoxins; D013880:Thioredoxin-Disulfide Reductase