Inflammation is detrimental for neurogenesis in adult brain.
New hippocampal neurons are continuously generated in the adult brain. Here, we demonstrate that lipopolysaccharide-induced inflammation, which gives rise to microglia activation in the area where the new neurons are born, strongly impairs basal hippocampal neurogenesis in rats. The increased neurogenesis triggered by a brain insult is also attenuated if it is associated with microglia activation caused by tissue damage or lipopolysaccharide infusion. The impaired neurogenesis in inflammation is restored by systemic administration of minocycline, which inhibits microglia activation. Our data raise the possibility that suppression of hippocampal neurogenesis by activated microglia contributes to cognitive dysfunction in aging, dementia, epilepsy, and other conditions leading to brain inflammation.
Ekdahl
Christine T
CT
Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, Biomedical Center A-11, Lund, Sweden.
Claasen
Jan-Hendrik
JH
Bonde
Sara
S
Kokaia
Zaal
Z
Lindvall
Olle
O
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000963:Antimetabolites / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D001973:Bromodeoxyuridine / Q000494:pharmacology; D006624:Hippocampus / Q000378:metabolism; D007150:Immunohistochemistry; D007249:Inflammation; D008070:Lipopolysaccharides / Q000378:metabolism / Q000494:pharmacology; D008297:Male; D017628:Microglia / Q000378:metabolism; D008911:Minocycline / Q000494:pharmacology; D009474:Neurons / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000900:Anti-Bacterial Agents; D000963:Antimetabolites; D008070:Lipopolysaccharides; D008911:Minocycline; D001973:Bromodeoxyuridine