Catalytic enantioselective transamination of alpha-keto esters: an organic approach to enzymatic reactions.
The half-transamination reaction of alpha-keto esters with pyridoxamine or 4-picolylamine was found to be catalysed by different metal catalysts in organic solvents giving moderate yields and enantioselectivities of up to 37% ee for methyl-3-indole pyruvate.
Danish National Research Foundation: Centre for Catalysis, Department of Chemistry, Aarhus University, DK-8000 Aarhus C, Denmark.
Kristian Rahbek
KR
Knudsen
Stephan
S
Bachmann
Karl Anker
KA
Jørgensen
D000586:Amination; D000588:Amines / Q000737:chemistry*; D032701:Biomimetics; D002384:Catalysis; D004798:Enzymes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D008670:Metals / Q000737:chemistry; D011733:Pyridoxamine / Q000737:chemistry; D011773:Pyruvates / Q000737:chemistry*; D013237:Stereoisomerism
D000588:Amines; D004798:Enzymes; D007659:Ketones; D008670:Metals; D011773:Pyruvates; C046522:ethyl pyruvate; D011733:Pyridoxamine