[Complement-binding and immuno-modulating properties of polyreactive immunoglobulins].
New data concerning biological properties of polyreactive immunoglobulins (PRIG) were obtained as a result of treatment of mouse serum immunoglobulins by 4 M KSCN and are presented in the paper. In particular, the capacity of PRIG to bind C1q, the subunit of the first component of complement was studied. It was shown that PRIG's binding capacity to C1q is similar to that of intact immunoglobulins. Intravenous administration of PRIG into mice together with either sheep red blood cells or heat-inactivated staphylococcal bacteria did not affect the immune response to these antigens. Meanwhile, the same administration of PRIG together with the purified protein derivate of tuberculin resulted in 10-fold increase of mouse antibody response to PPD. These results demonstrate that PRIG can have some immuno-modulating properties concerning low-immunogenic antigens.
Bobrovnik
S A
SA
Palladin Institute of Biochemistry, National Academy of Sciencis, Kyiv, Ukraine. sab@biochem.kiev.ua
Efetov
K A
KA
Petrova
Iu I
IuI
Komisarenko
S V
SV
D000276:Adjuvants, Immunologic / Q000378:metabolism*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000917:Antibody Formation / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000276:immunology; D001667:Binding, Competitive; D015922:Complement C1q / Q000276:immunology* / Q000378:metabolism; D005260:Female; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000276:immunology* / Q000378:metabolism; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
D000276:Adjuvants, Immunologic; D000911:Antibodies, Monoclonal; D000941:Antigens; D007136:Immunoglobulins; D015922:Complement C1q