The double life of ribosomal proteins.
Many integral proteins of the ribosome also carry out extra-ribosomal functions as independent polypeptides, raising questions as to their evolutionary derivation. In this issue of Cell, Mazumder et al. report a surprising new twist in the dual life of these molecules: as part of a cellular response to interferon, a large-subunit protein dramatically exits the ribosome to bind and inhibit the translation of a specific mRNA.
Department of Biochemistry & Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA.
Robert A
RA
Zimmermann
D002478:Cells, Cultured; D007371:Interferon-gamma / Q000494:pharmacology; D009000:Monocytes / Q000187:drug effects; D011485:Protein Binding; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D012269:Ribosomal Proteins / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism
D012333:RNA, Messenger; D012269:Ribosomal Proteins; D007371:Interferon-gamma