Constituents from the stems of Goniothalamus griffithii.
A new cyclopeptide, grifficyclocin A (1), and a new aporphine alkaloid, griffinin (2) were isolated together with two known styryllactones from the stems of Goniothalamus griffithii. Their structures were identified spectroscopically and chemically. Among them, the griffinin (2) was isolated as the enol form in two tautomers, and the two known styryllactones, goniothalamin (3) and 8- O-acetylgoniotriol (4), showed selective in vitro antitumor activities.
Phytochemistry Laboratory, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China. muqing2000@yahoo.com
Qing
Q
Mu
Wei Dong
WD
Tang
Ruo Yan
RY
Liu
Chao Ming
CM
Li
Li Guang
LG
Lou
Han Dong
HD
Sun
Chang Qi
CQ
Hu
D029061:Annonaceae / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001060:Aporphines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018547:Plant Stems / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; D010456:Peptides, Cyclic; D010936:Plant Extracts; C486518:grifficyclocin A; C486519:griffinin