Comparative immunoprofile of polymorphous low-grade adenocarcinoma and canalicular adenoma.
Immunohistochemistry is an important tool when dealing with salivary gland neoplasms. Canalicular adenoma and polymorphous low-grade adenocarcinoma may share some histologic characteristics that can cause difficulties in their separation. In the present study, cases of polymorphous low-grade adenocarcinoma and canalicular adenoma were submitted to a panel of antibodies to evaluate the differences in their immunoprofiles. The results obtained showed that, while vimentin is only expressed by polymorphous low-grade adenocarcinoma, CK7 and CK8 are present in both neoplasms. Therefore, vimentin is the best marker to differentiate between these tumors.
Department of Oral Pathology, School of Dentistry, University of São Paulo, Brazil.
Cristiane
C
Furuse
Renata
R
Tucci
Suzana O
SO
Machado de Sousa
Yasmin
Y
Rodarte Carvalho
Vera
V
Cavalcanti de Araújo
D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology*; D000236:Adenoma / Q000737:chemistry / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D053552:Keratin-7; D007633:Keratins / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000737:chemistry / Q000473:pathology; D014746:Vimentin / Q000032:analysis
D014408:Biomarkers, Tumor; C507497:KRT7 protein, human; D053552:Keratin-7; D014746:Vimentin; D007633:Keratins