Acupuncture modulates expressions of nitric oxide synthase and c-Fos in hippocampus after transient global ischemia in gerbils.
The effects of acupuncture on the expressions of nitric oxide synthase (NOS) and c-Fos in the hippocampus of gerbils after transient ischemia were investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry and Fos immunohistochemistry. In animals of the ischemia-induction groups, both common carotid arteries were occluded for 5 minutes. Animals of the acupunctued groups were given acupunctural treatment at Zusanli twice daily for 9 consecutive days. Acupuncture was shown to decrease NADPH-d and c-Fos levels in both the sham-operation group and the ischemia-induction group. These results suggest that acupuncture modulates the expressions of NOS and c-Fos in the hippocampus.
Department of Acupuncture and Meridianology, Graduate School of East-West Medical Science, Kyung Hee University, Yongin, Korea.
Ji-Eun
JE
Kang
Hye-Jung
HJ
Lee
Sabina
S
Lim
Ee-Hwa
EH
Kim
Tae-Hee
TH
Lee
Mi-Hyeon
MH
Jang
Min-Chul
MC
Shin
Baek-Vin
BV
Lim
Youn-Jung
YJ
Kim
Chang-Ju
CJ
Kim
D026881:Acupuncture; D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism / Q000517:prevention & control*; D005849:Gerbillinae; D006624:Hippocampus / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*
D016760:Proto-Oncogene Proteins c-fos; D019001:Nitric Oxide Synthase; D009252:NADPH Dehydrogenase