Leptin regulates functional capacities of polymorphonuclear neutrophils.
Recent studies report that leptin may be able to modulate some functions of cells involved in non-specific immune response. We recently found that a functional leptin receptor is present on polymorphonuclear neutrophils (PMNs) and may be able to influence their oxidative capacities. We demonstrate here for the first time that leptin is also able to stimulate chemotaxis of PMNs and exerts by itself a chemoattractive effect comparable to that of well-known formyl-methionyl-leucyl-phenylalanine, and a stimulating effect on intracellular hydrogen peroxide production, without modification of phagocytosis.
Laboratoire de Biochimie, Biologie Moléculaire et Nutrition, Faculté de Pharmacie, 28 place Henri-Dunant, B.P. 38, 63001 Clermont-Ferrand 1, France. florence.caldefie-chezet@u-clermont1.fr
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Caldefie-Chezet
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Poulin
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Vasson
D002478:Cells, Cultured; D002633:Chemotaxis; D004305:Dose-Response Relationship, Drug; D005434:Flow Cytometry; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism / Q000494:pharmacology; D020738:Leptin / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D007962:Leukocytes / Q000378:metabolism; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000378:metabolism; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D010587:Phagocytosis; D017382:Reactive Oxygen Species; D012685:Sepharose / Q000494:pharmacology
D020738:Leptin; D017382:Reactive Oxygen Species; D009240:N-Formylmethionine Leucyl-Phenylalanine; D012685:Sepharose; D006861:Hydrogen Peroxide; D010100:Oxygen