[Estradiol-17beta activates corticosteroid synthesis and inhibits proliferation in cultured porcine adrenocortical cells].
The influence of estradiol-17 beta on corticosteroids production and cell proliferation were studied in the cultured pig adrenocortical cells. Estradiol-17 beta considerably increased steroidogenesis, but inhibited cell proliferation. It is speculated, that cAMP mediated estradiol-17 beta effects in the adrenal cells.
V. P. Komissarenko Institute of Endocrinology and Metabolism, Academy of Medical Sciences of Ukraine, Kyiv.
A S
AS
Mikosha
E I
EI
Kovzun
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EN
Grinchenko
D000302:Adrenal Cortex / Q000166:cytology / Q000378:metabolism*; D000305:Adrenal Cortex Hormones / Q000096:biosynthesis*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004958:Estradiol / Q000494:pharmacology*; D013552:Swine
D000305:Adrenal Cortex Hormones; D004958:Estradiol