Urinary excretion of retinol in patients with multiple myeloma: a preliminary study.
Urinary excretion of vitamin A was studied in patients with multiple myeloma (MM). Eight of the 12 patients studied excreted retinol in urine; only one of them had elevated serum creatinine (115-150 micromol/L). There was a highly significant correlation between urinary retinol and serum creatinine (P < 0.0004). Urinary retinol correlated also with urine protein (P < 0.0001) and albumin (P = 0.001), but not with urinary immunoglobulin light chains. Urinary retinol excretion may be an early manifestation of renal dysfunction in MM patients. The effect of urinary retinol excretion on vitamin A homeostasis in MM deserves further study.
Pediatric Pharmacology Laboratory, Soroka Medical Center and Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. vladimirgav@hotmail.com
Vladimir
V
Gavrilov
Tikva
T
Yermiahu
Rafael
R
Gorodischer
D000328:Adult; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000097:blood / Q000652:urine; D005198:Fanconi Syndrome / Q000209:etiology / Q000652:urine; D005260:Female; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000652:urine*; D051437:Renal Insufficiency / Q000209:etiology / Q000652:urine; D014801:Vitamin A / Q000378:metabolism / Q000652:urine*
D014801:Vitamin A; D003404:Creatinine