Genomic organization and transcription of the human retinol dehydrogenase 10 (RDH10) gene.
A cDNA clone up-regulated in hydraulic lung edema in rabbit showed high similarity with human RDH10 mRNA, which encodes a protein involved in retinoic acid metabolism. We defined the organization of the human gene, which includes a unique transcriptional start site, a coding region with six translated exons and a 3' untranslated region containing at least two used polyadenylation sites. The two poly(A) signals are responsible for the production of the 3 and 4 kb RDH10 mRNA isoforms detected in several human tissues and cell lines.
Picozzi
P
P
Department of Biology and Genetics for Medical Sciences, University of Milan, Via Viotti 3/5, 20133 Milan, Italy.
Marozzi
A
A
Fornasari
D
D
Benfante
R
R
Barisani
D
D
Meneveri
R
R
Ginelli
E
E
D020413:3' Untranslated Regions; D000429:Alcohol Oxidoreductases / Q000235:genetics*; D001483:Base Sequence; D040461:Gene Components / Q000235:genetics*; D005796:Genes / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D009928:Organ Specificity; D020033:Protein Isoforms; D039104:RNA 3' Polyadenylation Signals; D020871:RNA Stability; D012333:RNA, Messenger / Q000032:analysis / Q000378:metabolism; D014018:Tissue Distribution; D024363:Transcription Initiation Site; D014158:Transcription, Genetic
D020413:3' Untranslated Regions; D020033:Protein Isoforms; D012333:RNA, Messenger; D000429:Alcohol Oxidoreductases; C022520:retinol dehydrogenase