[Protein C system and thrombosis diseases].
The mechanism of protein C system functioning and role of its components in the regulation of the coagulation and the fibrinolysis was considered in the review. There are also new data about the anticoagulation, profibrinolysis and antiinflammatory functions of protein C system. Activated protein C is inhibited by the protein C inhibitor, alpha 1-antitripsin, and inhibitor of tissue activator plasminogen-1. Hereditary or acquired deficiency of protein C, protein S and thrombomodulin lead to thrombotic diseases. Injection of exogenous recombinant protein C or activated protein C into the blood increases the anticoagulant activity of the blood and produced the antithrombotic effect.
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv. taran48@yandex.ru
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D020016:Activated Protein C Resistance / Q000097:blood; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000494:pharmacology; D006490:Hemostatics / Q000494:pharmacology; D006801:Humans; D011486:Protein C / Q000378:metabolism* / Q000494:pharmacology; D020151:Protein C Deficiency / Q000378:metabolism; D018046:Protein C Inhibitor / Q000494:pharmacology; D017293:Protein S / Q000378:metabolism / Q000494:pharmacology; D011994:Recombinant Proteins / Q000494:pharmacology; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology; D013917:Thrombin / Q000378:metabolism / Q000494:pharmacology; D018180:Thrombomodulin / Q000378:metabolism; D013927:Thrombosis / Q000097:blood* / Q000209:etiology / Q000378:metabolism
D000925:Anticoagulants; D005343:Fibrinolytic Agents; D006490:Hemostatics; D011486:Protein C; D018046:Protein C Inhibitor; D017293:Protein S; D011994:Recombinant Proteins; D015842:Serine Proteinase Inhibitors; D018180:Thrombomodulin; D013917:Thrombin