[Expression of oncogene C-jun in the cells of rat nasal mucosa and relevance with rhinorrhea].
OBJECTIVE
To study the expression of oncogene C-jun in rat nasal mucosa with allergic rhinitis and the relevance with rhinorrhea.


METHODS
By using EA to make animal model of allergic rhinitis successfully; the amount of rhinorrhea was calculated at 30 min. 4 h, 8 h. Immunohistochemical technique, computer image analysis technique and histologic examination were used to investigated the expression of C-jun in rat nasal mucosa at the same time. The relevance between them was used explored.


RESULTS
There was a lot of C-jun protein at 30 min. The difference of C-jun between 30 min group and control group was significant (P < 0.01) and the relevant coefficient was r = 0.784 (P < 0.05). The C-jun protein decreased at 4 h, but there was still significant difference (P < 0.05) and r = 0.626 (P < 0.05). The C-jun was as same as control group at 8 h, There was no difference between them.


CONCLUSIONS
The expression of oncogene C-jun in inflammatory cells may be a marker in early stage of activation of inflammatory cells, and related to the producing and secreting of cytokines and inflammatory mediators in inflammatory cells of allergic rhinitis.
Department of Otolaryngology, Huaxi Hospital, Sichuan University, Chengdu 610044.
Guanghui
G
Wang
Hong
H
Mou
Zhengxin
Z
Ren
Chuanyu
C
Liang
Qinxiu
Q
Zhang
D000818:Animals; D002559:Cerebrospinal Fluid Rhinorrhea / Q000150:complications; D009297:Nasal Mucosa / Q000378:metabolism / Q000473:pathology*; D016755:Proto-Oncogene Proteins c-jun / Q000096:biosynthesis*; D051381:Rats; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism / Q000473:pathology*
D016755:Proto-Oncogene Proteins c-jun