In vitro activity of recombinant lysostaphin against Staphylococcus aureus isolates from anterior nares and blood.
The in vitro activity of recombinant lysostaphin was tested against a collection of well-characterized clinical Staphylococcus aureus isolates by disk diffusion (429 isolates) and minimum bactericidal concentration (10 isolates) assays. Minimum bactericidal concentrations of 0.16 microg/ml and zones of inhibition ranging between 15 and 21 mm in diameter demonstrate that lysostaphin was highly active against all isolates tested.
Institute of Medical Microbiology, University of Münster Hospital and Clinics, 48149 Muenster, Germany. eiffc@uni-muenster.de
Christof
C
von Eiff
John F
JF
Kokai-Kun
Karsten
K
Becker
Georg
G
Peters
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology; D002353:Carrier State / Q000382:microbiology; D006801:Humans; D008248:Lysostaphin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009297:Nasal Mucosa / Q000382:microbiology*; D011994:Recombinant Proteins / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000097:blood / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D011994:Recombinant Proteins; D008248:Lysostaphin