Polymyositis masquerading as mitochondrial toxicity.
A 66 year old HIV infected male heavy smoker presented with arthralgia, myalgia, and weight loss which was originally ascribed to nucleoside induced mitochondrial toxicity. Despite withdrawal of antiretroviral therapy a proximal myopathy developed. Further investigation excluded malignancy. Polymyositis was diagnosed on muscle biopsy. The patient recovered completely with oral prednisolone. This case highlights the importance of muscle biopsy in HIV infected patients whose myopathy persists despite withdrawal of antiretroviral therapy and the need for thorough investigation of non-specific symptoms in HIV infected patients who are receiving antiretroviral therapy.
Prime
K P
KP
Department of Genitourinary Medicine, Camden Primary Care Trust, Mortimer Market Centre, London WC1E 6AU, UK. katiaprime@hotmail.com
Edwards
S G
SG
Pakianathan
M R
MR
Holton
J L
JL
Scaravilli
F
F
Miller
R F
RF
D000368:Aged; D044966:Anti-Retroviral Agents / Q000009:adverse effects; D003937:Diagnosis, Differential; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008297:Male; D028361:Mitochondrial Diseases / Q000139:chemically induced* / Q000175:diagnosis; D017285:Polymyositis / Q000175:diagnosis* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use
D044966:Anti-Retroviral Agents; D011239:Prednisolone