Genotoxicity of nimesulide in murine bone marrow cells.
The genotoxic potentiality of nimesulide was evaluated in vivo in murine bone marrow cells. The human equivalent prophylactic dose of nimesulide (5 mg/kg body wt/day) was given to animals orally, once daily for seven consecutive days. Metaphase chromosome analyses revealed the significant increase in the incidence of chromosomal aberrations with preference to structural over the numerical ones. It therefore suggested the clastogenic effect of the nimesulide. The molecular mechanism of mutagenesis is yet to be determined.
Department of Zoology, Patna Women's College, Patna 800 001, India. Parimal_khan@yahoo.co.in
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D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000633:toxicity*; D001854:Bone Marrow Cells / Q000187:drug effects*; D002869:Chromosome Aberrations / Q000187:drug effects*; D020732:Cytogenetic Analysis; D005260:Female; D008297:Male; D008677:Metaphase; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000008:administration & dosage / Q000633:toxicity*; D013449:Sulfonamides / Q000008:administration & dosage / Q000633:toxicity*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009153:Mutagens; D013449:Sulfonamides; C012655:nimesulide