Synthesis and DNA-binding affinity of A-C8/C-C2 alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.
The synthesis of new A-C8/C-C2 alkoxyamido-linked pyrrolo[2,1-c][1,4]-benzodiazepine dimers have been described in this report. These dimers exhibit significant DNA-binding ability with moderate anticancer activity.
Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500007, India. ahmedkamal@iict.ap.nic.in
Ahmed
A
Kamal
P
P
Ramulu
O
O
Srinivas
G
G
Ramesh
D000970:Antineoplastic Agents / Q000138:chemical synthesis; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology*; D001665:Binding Sites; D004247:DNA / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D019281:Dimerization; D009691:Nucleic Acid Denaturation; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D011758:Pyrroles; D001569:Benzodiazepines; D004247:DNA