Effect of morphine, naloxone and histamine system on water intake in adult male rats.
The present study investigated the interaction between histamine and opioid systems on water intake in adult male rats. Intracerebroventricular (i.c.v.) injections were carried out in all experiments. Water intake was measured 1 h after drug injections. Administration of histamine (40-80 microg/rat) and naloxone (0.5-1 microg/rat) increased, while morphine (2.5 microg/rat), pyrilamine (25-50 microg/rat), the histamine H1 receptor antagonist, and ranitidine (10-20 microg/rat), the histamine H2 receptor antagonist, decreased water intake in isolated rats. Blockade of histamine H1 and H2 receptors attenuated the histamine-induced response. Pyrilamine, but not ranitidine, increased the inhibitory effect induced by morphine. Also, pharmacological blockade of histamine H1 and H2 receptors decreased the naloxone-induced effect on water intake. It is concluded that the histaminergic system may have a close interaction with morphine and naloxone on drinking behavior.
Department of Biology, Varamin Unit, Islamic Azad University, Varamin, Iran.
Maryam
M
Eidi
Shahrbanoo
S
Oryan
Akram
A
Eidi
Leili
L
Sepehrara
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D004326:Drinking / Q000187:drug effects*; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011969:Receptors, Histamine H1 / Q000187:drug effects; D011970:Receptors, Histamine H2 / Q000187:drug effects
D000701:Analgesics, Opioid; D006634:Histamine H1 Antagonists; D006635:Histamine H2 Antagonists; D009292:Narcotic Antagonists; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D009270:Naloxone; D009020:Morphine; D006632:Histamine