Simultaneous in vitro assay of the first four enzymes in the fungal aspartate pathway identifies a new class of aspartate kinase inhibitor.
Bareich
David C
DC
Antimicrobial Research Centre, Department of Biochemistry, McMaster University, 1200 Main Street, West Hamilton, Ontario L8N 3Z5, Canada.
Nazi
Ishac
I
Wright
Gerard D
GD
D000123:Acetyltransferases / Q000032:analysis / Q000378:metabolism; D000613:Aminobutyrates / Q000494:pharmacology; D000622:Aminolevulinic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D001222:Aspartate Kinase / Q000032:analysis / Q000037:antagonists & inhibitors* / Q000378:metabolism; D001223:Aspartate-Semialdehyde Dehydrogenase / Q000032:analysis / Q000378:metabolism; D001224:Aspartic Acid / Q000378:metabolism*; D001665:Binding Sites; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006715:Homoserine Dehydrogenase / Q000032:analysis / Q000378:metabolism; D007700:Kinetics; D009842:Oligopeptides / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000494:pharmacology; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D000613:Aminobutyrates; D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D009842:Oligopeptides; D009943:Organophosphorus Compounds; C063847:rhizocticin A; C089089:azoxybacilin; D001224:Aspartic Acid; C058222:2-amino-5-hydroxy-4-oxopentanoic acid; D000622:Aminolevulinic Acid; D006715:Homoserine Dehydrogenase; D001223:Aspartate-Semialdehyde Dehydrogenase; D000123:Acetyltransferases; C021369:homoserine O-acetyltransferase; D001222:Aspartate Kinase