[Nutrition and health--unclear association between intake of vitamin E and the risk of coronary heart disease].
Vitamin E is a fat-soluble antioxidant and is possibly involved in the prevention of coronary heart disease by inhibiting oxidative modification of LDL cholesterol. The results of studies on the association between vitamin-E intake and coronary heart disease are inconsistent in observational studies and absent in large-scale intervention studies. This may be the consequence of confounding in observational studies and imperfections in the design of intervention trials. Another explanation is that vitamin E may only function protectively in the presence of sufficient co-antioxidants. At present, there is no evidence that vitamin E lowers the risk of coronary heart disease.
Buijsse
B
B
Rijksinstituut voor Volksgezondheid en Milieu (RIVM), Centrum voor Voeding en Gezondheid, Postbus 1, 3720 BA Bilthoven. brian.buijsse@rivm.nl
Feskens
E J M
EJ
Kromhout
D
D
D000975:Antioxidants / Q000008:administration & dosage* / Q000627:therapeutic use; D015986:Confounding Factors, Epidemiologic; D003327:Coronary Disease / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D010084:Oxidation-Reduction; D012307:Risk Factors; D014810:Vitamin E / Q000008:administration & dosage* / Q000627:therapeutic use
D000975:Antioxidants; D014810:Vitamin E