Synthesis and relative binding affinity to human steroid receptors of substituted 3-aryloxycoumarins.
The synthesis of a set of substituted 3-aryloxycoumarins was performed. The study of the relations between their structure and their relative binding affinity to human androgen, progesterone, alpha and beta estrogen receptors was achieved.
Bakhchinian
Robert
R
Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie de PARIS-SUD, 5 rue Jean-Baptiste Clément, F-92296 Cedex, Chatenay Malabry, France.
Terrier
François
F
Kirkiacharian
Serge
S
Resche-Rigon
Michèle
M
Bouchoux
Françoise
F
Cérède
Evelyne
E
D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D003374:Coumarins / Q000138:chemical synthesis* / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding / Q000502:physiology; D011987:Receptors, Steroid / Q000378:metabolism*
D003374:Coumarins; D011987:Receptors, Steroid