Use of N-protected amino acids in the Minisci radical alkylation.
[reaction: see text] The Minisci radical alkylation has been demonstrated on a range of commercially available glycine derivatives and proceeds in good to high yield. When extending the reaction to other amino acids, competitive oxidation of the initially formed radical was overcome by using the phthalimide protecting group.
Cowden
Cameron J
CJ
Department of Process Research, Merck & Co. Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA. cameron_cowden@merck.com
D000478:Alkylation; D000596:Amino Acids / Q000737:chemistry*
D000596:Amino Acids