[Antibacterial effect of nitric oxide].
In this study, the antibacterial effects of nitric oxide (NO) have been investigated against 4 strains of multidrug-resistant Mycobacterium tuberculosis and 8 Klebsiella, 7 Escherichia coli, 7 Staphylococcus, 5 Enterobacter, 7 Pseudomonas and 7 Proteus clinical isolates by using DETA-NO ((Z)-1-[N-(2-aminoethyl)-N-(2-ammonioethyl)amino]diazen-1-ium-1,2-diolate) as the NO donor. Minimum inhibitory concentrations (MICs) were determined by broth microdilution method for all tested microorganisms. The MIC values found in our study were as follows; 0.25 mg/ml for all of the multidrug-resistant Mycobacterium tuberculosis strains, 1 mg/ml for Staphylococcus strains, and approximately 2 mg/ml for the rest of the bacterial strains. These results showed that NO (or NO donor DETA-NO) was more effective on multidrug-resistant M. tuberculosis strains than the other bacterial species. It can be concluded that further studies are needed to explain the clinical use of NO donor DETA-NO, especially, in patients infected with multidrug-resistant M. tuberculosis.
Ondokuz Mayis Universitesi Tip Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Samsun.
Ahmet Yilmaz
AY
Coban
Gülçin
G
Bayramoğlu
Bora
B
Ekinci
Belma
B
Durupinar
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D004754:Enterobacter / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007709:Klebsiella / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009569:Nitric Oxide / Q000494:pharmacology*; D011511:Proteus / Q000187:drug effects; D011549:Pseudomonas / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D009569:Nitric Oxide