Methylation: a second hit in the two-hit hypothesis.
This case illustrates that methylation of one BRCA1 allele may serve as the second hit in a patient with a diploid locus and missense mutation on the other allele.
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
J P
JP
Geisler
J A
JA
Rathe
K J
KJ
Manahan
H E
HE
Geisler
D000483:Alleles; D002277:Carcinoma / Q000235:genetics*; D019175:DNA Methylation; D005260:Female; D020868:Gene Silencing; D019398:Genes, BRCA1; D006801:Humans; D020125:Mutation, Missense; D010051:Ovarian Neoplasms / Q000235:genetics*; D016133:Polymerase Chain Reaction; D018807:Polymorphism, Single-Stranded Conformational