Synergism between the brushite and hydroxyapatite urinary crystallization inhibitors.
The aim of this paper is to study possible synergic effects between crystallization-inhibitor molecules of low molecular weight on the hydroxyapatite and brushite crystal nucleation. Kinetic-turbidimetric measurements were performed to follow the nucleation process in synthetic urine at 37 degrees C. Only pyrophosphate + phytate mixture manifested synergic effects on the brushite nucleation, whereas the mixture pyrophosphate + citrate exhibited synergic effects only on the hydroxyapatite nucleation. It seems clear that synergic effects between the crystallization inhibitory capacity of some substances in urine can take place and as a consequence, the high crystallization inhibitory capacity of healthy urine could be assigned not only to the individual inhibitory capacity of each product but also to the synergic effects between different products.
Costa-Bauzá
Antonia
A
Laboratory of Renal Lithiasis Research, Faculty of Sciences, University of Illes Balears 07071, Palma de Mallorca, Spain.
Barceló
Catalina
C
Perelló
Juan
J
Grases
Felix
F
D002130:Calcium Phosphates / Q000652:urine*; D002951:Citrates / Q000652:urine; D003460:Crystallization; D011756:Diphosphates / Q000652:urine; D004357:Drug Synergism; D017886:Durapatite / Q000652:urine*; D006801:Humans; D007669:Kidney Calculi / Q000652:urine; D008970:Molecular Weight; D010833:Phytic Acid / Q000652:urine; D000077559:Sodium Citrate
D002130:Calcium Phosphates; D002951:Citrates; D011756:Diphosphates; D000077559:Sodium Citrate; D010833:Phytic Acid; D017886:Durapatite; C003319:sodium pyrophosphate; C494366:calcium phosphate, dibasic, dihydrate