Ran in the spindle checkpoint: a new function for a versatile GTPase.
The small GTPase Ran has a well-established role in nucleocytoplasmic trafficking. In recent years, the repertoire of Ran has expanded to include regulation of spindle assembly, formation of the nuclear envelope and DNA replication. Now, new studies further extend the role of Ran to regulating the spindle checkpoint during mitosis.
Li
Hoi-Yeung
HY
Department of Embryology, Carnegie Institution of Washington and Howard Hughes Medical Institute, Johns Hopkins University, 115 West University Parkway, Baltimore, MD 21210, USA.
Cao
Kan
K
Zheng
Yixian
Y
D000818:Animals; D018797:Cell Cycle Proteins; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D009687:Nuclear Proteins; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000502:physiology*; D014981:Xenopus; D029867:Xenopus Proteins; D020931:ran GTP-Binding Protein / Q000235:genetics / Q000502:physiology*
D018797:Cell Cycle Proteins; D020662:Guanine Nucleotide Exchange Factors; D009687:Nuclear Proteins; C499304:RCC1 protein, Xenopus; D029867:Xenopus Proteins; D020931:ran GTP-Binding Protein