Relationship between hyperinsulinemia and pulse wave velocity in moderately hyperglycemic patients.
OBJECTIVE
Arterial stiffness assessed by pulse wave velocity (PWV) reflects early stage arteriosclerosis. The influence of hyperinsulinemia on peripheral vascular disease (PVD) is still unknown. We determined the influences of hyperinsulinemia on PVD assessed by PWV in moderately hyperglycemic patients.


METHODS
Thirty-six moderately hyperglycemic, outcoming patients were recruited in this study. All subjects were divided into two groups by fasting immunoreactive insulin (F-IRI) concentrations; group A; F-IRI> or =5 microU/ml, group B; F-IRI<5 microU/ml. Both hbPWV (from heart to brachial artery) and baPWV (brachial to artery to ankle) were evaluated by using Form PWV/ABI, in addition to ankle-brachial pressure index (ABPI).


RESULTS
In group A, both hbPWV and baPWV showed significantly higher values than in group B. ABPIs were not different between two groups. Although age, FPG, plasma HbA1c, serum total-cholesterol, HDL-cholesterol concentrations, and systolic and diastolic blood pressure were at same levels in group A as group B, body mass index, HOMA-R, serum triglyceride concentrations were significantly higher in group A, indicating the existence of insulin resistance in group A.


CONCLUSIONS
Hyperinsulinemia may be involved in the development of PVD in moderately hyperglycemic patients.
Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
Miki
M
Koizumi
Hiroyuki
H
Shimizu
Kenju
K
Shimomura
Shinsuke
S
Oh-I
Yasuyo
Y
Tomita
Tomohiro
T
Kudo
Ken-Ichi
K
Iizuka
Masatomo
M
Mori
D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D001916:Brachial Artery / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000503:physiopathology*; D006946:Hyperinsulinism / Q000097:blood / Q000503:physiopathology*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010991:Plethysmography
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D008055:Lipids