Asymmetric synthesis of 4,4-disubstituted-2-imidazoli-dinones: potent NK1 antagonists.
[structure: see text] A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a "self-reproduction of the center of chirality" strategy is described.
Reichard
Gregory A
GA
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA.
Stengone
Carmine
C
Paliwal
Sunil
S
Mergelsberg
Ingrid
I
Majmundar
Sapna
S
Wang
Cheng
C
Tiberi
Robert
R
McPhail
Andrew T
AT
Piwinski
John J
JJ
Shih
Neng-Yang
NY