Acivicin induce filamentous growth of Saccharomyces cerevisiae.
The antibiotic acivicin is a known inhibitor of gamma-glutamyl transpeptidase (gammaGTP). We found that acivicin can induce filamentous growth in both diploid and haploid cells of Saccharomyces cerevisiae. This phenomenon is not related to the inhibition of gammaGTP or interference in glutathione metabolism. Interestingly, yeasts used in the brewing industry are more sensitive to acivicin, suggesting that this dimorphological differentiation may be related to some characteristics of these particular strains.
Industrial Technology Center of Okayama Prefecture, Haga, Okayama, Japan. tsuyoshi_miyake@pref.okayama.jp
Tsuyoshi
T
Miyake
Hiroyuki
H
Sammoto
Bun-ichiro
B
Ono
D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007555:Isoxazoles / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000254:growth & development; D005723:gamma-Glutamyltransferase / Q000037:antagonists & inhibitors
D007555:Isoxazoles; D005723:gamma-Glutamyltransferase; C006303:acivicin