Diastolic heart failure: old story, new concepts.
Diastolic heart failure refers to a clinical syndrome characterised by symptoms and signs of congestive heart failure, with a normal or subnormal left ventricular (LV) systolic function associated with alterations in LV diastolic function. Diastolic dysfunction is a pathological condition during which the LV is unable to accept a volume of blood coming back from the lungs appropriate to maintain its stroke volume under normal filling pressure. Three eventually associated mechanisms are responsible for such dysfunction: impaired LV relaxation, increased LV stiffness and loss of normal atrial function. Prevention of LV hypertrophic remodelling should decrease the incidence of diastolic heart failure.
Departments of Physiology and Cardiology, Groupe Hospitalier Bichat-Claude Bernard, 75018 Paris.
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JJ
Mercadier
D006333:Heart Failure / Q000473:pathology*; D006801:Humans; D013599:Systole; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling