[An experimental infection caused by the EP-2 strain of cowpox virus in mice of different ages].
The specificity of lethal infection was studied in noninbred white mice (age--15 to 20 and 25 to 30 days) infected intraperitoneally with the EP-2 strain of cowpox virus (CPV) in doses 10(5), 10(6) and 10(7) PFU. The virus caused the lethal infection in the 15-20-day mice; while the 25-30-day mice remained healthy and survived. Virologic, immunologic-and-histochemical and electron-microscopy examinations of the 15-20-day mice revealed a replication of the EP-2 strain in tissues bordering on the virus introduction area; there was no generalization of infection. The virus replicated first in the mesothelium cells, and after that, in fibroblasts as well as in the endothelial, fatty, adventicial, cross-striated and muscle cells and in myosatellites.
Vinogradov
I V
IV
Kochneva
G V
GV
Malkova
E M
EM
Shchelkunov
S N
SN
Riabchikova
E I
EI
D000273:Adipose Tissue / Q000821:virology; D000367:Age Factors; D000818:Animals; D015605:Cowpox / Q000473:pathology / Q000821:virology*; D015608:Cowpox virus / Q000472:pathogenicity*; D004195:Disease Models, Animal; D042783:Endothelial Cells / Q000821:virology; D004848:Epithelium / Q000821:virology; D005347:Fibroblasts / Q000821:virology; D007150:Immunohistochemistry; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D018482:Muscle, Skeletal / Q000821:virology; D013194:Staining and Labeling; D014779:Virus Replication