[Oncologic risk factors in papillomavirus infection].
Cytological screening is essential for adequate diagnosis of gynecological cancer. Moreover, every effort should be made to identify such risks of cancer as viruses (HPV, Herpes simplex, cytomegalovirus, Epstein-Barr virus, etc.). When high risk HPV-16 and HPV-18 are detected, diagnostic strategies should include assay of blood prolactin and prolactin/TTH ratio. Virus-related tumors and various risk groups may be studied using HPV genotyping detection of high-risk alleles of certain genes. Hence, some HPV gene variants and gene polymorphism can be investigated as potential risk factors in women.
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, I.P. Pavlov State Medical University, St. Petersburg.
N R
NR
Safronnikova
M I
MI
Zaraĭskiĭ
A B
AB
Chukhlovin
D000483:Alleles; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D014644:Genetic Variation; D005833:Genital Neoplasms, Female / Q000097:blood / Q000821:virology*; D005838:Genotype; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000097:blood / Q000150:complications*; D011110:Polymorphism, Genetic; D011388:Prolactin / Q000097:blood; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000097:blood / Q000150:complications*
D004279:DNA, Viral; D011388:Prolactin