Efficacy and tolerability of short-term specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A (MPL) for children and adolescents.
BACKGROUND
Specific immunotherapy (SIT) with pollen allergoids formulated with the Th1-inducing adjuvant 3-deacylated monophosphoryl lipid A (MPL adjuvant, Corixa) has shown good efficacy and tolerability in the treatment of pollen allergies in adults. The aim of this study was to evaluate this treatment in children and adolescents aged 6-17 years old who were sensitive to grass/rye or tree pollens.


METHODS
An open, multicenter study was performed using 90 children and adolescents. The patients received four subcutaneous injections of grass/rye (n = 64) or tree pollen allergoids (n = 26) adsorbed to L-tyrosine and containing MPL adjuvant. Efficacy was measured by symptom and medication scoring, skin prick test reactivity and IgG/IgE antibody responses. Tolerability was monitored by recording adverse events.


RESULTS
Both grass/rye and tree pollen treatment groups showed significant reductions in symptom scores and anti-allergic medication use compared with the previous pollen seasons (p < 0.01 in all cases). After therapy, skin prick test reactivity was significantly reduced in both groups and pollen-specific IgG was significantly increased in both groups whereas little change was apparent in pollen-specific IgE. Overall tolerability was similar to results obtained in previous studies in adults.


CONCLUSIONS
Short-term SIT using four injections of grass/rye or tree pollen allergoids adsorbed to L-tyrosine and with MPL adjuvant was shown to be effective with good tolerability. The treatment compared favorably with previous studies in adults.
Drachenberg
K J
KJ
Bencard Allergie GmbH, Munich, Germany.
Heinzkill
M
M
Urban
E
E
Woroniecki
S R
SR
D000276:Adjuvants, Immunologic; D000293:Adolescent; D000485:Allergens / Q000276:immunology*; D000918:Antibody Specificity; D002648:Child; D003888:Desensitization, Immunologic / Q000009:adverse effects; D004487:Edema / Q000209:etiology; D004890:Erythema / Q000209:etiology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008050:Lipid A / Q000031:analogs & derivatives* / Q000276:immunology*; D008297:Male; D006109:Poaceae; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*; D012434:Secale; D014197:Trees
D000276:Adjuvants, Immunologic; D000485:Allergens; D007074:Immunoglobulin G; D008050:Lipid A; D007073:Immunoglobulin E; C048436:monophosphoryl lipid A