Aging: the sins of the parents.
Yeast cells have an asymmetric, stem-cell-like division. As the mother cell ages it becomes 100 times more genetically unstable, but it is only the daughter cells that exhibit loss of heterozygosity; the latter effect is not connected to SIR2-dependent aging, but seems to be accompanied by a loss of the DNA damage checkpoint.
Rosenstiel Center MS029, Brandeis University, Waltham, Massachusetts 02454-9110, USA.
James E
JE
Haber
D019070:Cell Lineage / Q000502:physiology*; D004249:DNA Damage / Q000502:physiology; D004268:DNA-Binding Proteins / Q000378:metabolism; D006655:Histone Deacetylases / Q000378:metabolism; D019656:Loss of Heterozygosity / Q000502:physiology*; D012097:Repressor Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae / Q000378:metabolism; D056565:Sirtuin 2; D037761:Sirtuins / Q000378:metabolism; D013997:Time Factors; D014157:Transcription Factors / Q000378:metabolism
C098733:ASH1 protein, S cerevisiae; D004268:DNA-Binding Proteins; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D014157:Transcription Factors; C087778:SIR2 protein, S cerevisiae; D056565:Sirtuin 2; D037761:Sirtuins; D006655:Histone Deacetylases