Is agranulocytosis following infectious mononucleosis caused by autoimmunity?
A patient developed agranulocytosis after Epstein-Barr infection. Bone marrow examination revealed normal myelopoiesis with reduced mature neutrophil polymorphonuclear cells. IgG-specific antineutrophil antibodies (anti-HNA-1a) were found in serum and on polymorphonuclear cells, suggesting that the agranulocytosis after infectious mononucleosis was caused by an autoimmune mechanism.
Department of Pediatrics, Faculty of Medicine and Children's Hospital, Lille, France. stephane.auvin@free.fr
Stéphane
S
Auvin
Jean-Hugues
JH
Dalle
Patrice-Serge
PS
Ganga-Zandzou
Hubert
H
Ythier
D000380:Agranulocytosis / Q000209:etiology* / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology; D002648:Child; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007244:Infectious Mononucleosis / Q000150:complications* / Q000276:immunology; D008297:Male; D009504:Neutrophils / Q000276:immunology
D007074:Immunoglobulin G; D007075:Immunoglobulin M