Lactones from the leaves of Litsea japonica and their anti-complement activity.
Two new lactones, litsealactone A (1) and litsealactone B (2), were isolated from the leaves of Litsea japonica, together with three known lactones, hamabiwalactone A (3), hamabiwalactone B (4), and akolactone B (5). Hamabiwalactone B (4) and akolactone B (5) significantly inhibited complement activity in an in vitro anti-complement assay, with IC(50) values of 149 and 58 muM, respectively.
Min
Byung Sun
BS
Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Korea.
Lee
Sun Young
SY
Kim
Jung Hee
JH
Kwon
Ok Kyoung
OK
Park
Bo Young
BY
An
Ren Bo
RB
Lee
Joong Ku
JK
Moon
Hyung In
HI
Kim
Tae Jin
TJ
Kim
Young Ho
YH
Joung
Hyouk
H
Lee
Hyeong Kyu
HK
D003169:Complement Inactivator Proteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007723:Korea; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D003169:Complement Inactivator Proteins; D007783:Lactones