TSH, the bone suppressing hormone.
The skeleton is a dynamic organ whose structural integrity depends on constant remodeling, controlled by many local and systemic factors. In this issue of Cell, identify thyroid-stimulating hormone (TSH) as an important regulator of this process.
Novack
Deborah Veis
DV
Department of Medicine, Division of Bone and Mineral Diseases, Washington University School of Medicine, Saint Louis, MO 63110, USA.
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D016723:Bone Remodeling / Q000187:drug effects*; D001842:Bone and Bones / Q000502:physiology; D002454:Cell Differentiation; D002478:Cells, Cultured; D006023:Glycoproteins / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D053244:Osteoprotegerin; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D011989:Receptors, Thyrotropin / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor; D013972:Thyrotropin / Q000378:metabolism / Q000502:physiology*
D006023:Glycoproteins; D053244:Osteoprotegerin; D018160:Receptors, Cytoplasmic and Nuclear; D011989:Receptors, Thyrotropin; D018124:Receptors, Tumor Necrosis Factor; C506031:Tnfrsf11b protein, mouse; D013972:Thyrotropin