Simulation of human gentamicin pharmacokinetics in an experimental Enterococcus faecalis endocarditis model.
Significant differences between animal and human pharmacokinetics may be responsible for the conflicting results of experimental studies. This study determined the impact of human pharmacokinetic simulation (HPS) on gentamicin activity in an Enterococcus faecalis endocarditis model. The decrease in bacterial counts was greater with HPS than with a dose-equivalent regimen without HPS.
Dubé
Laurent
L
Laboratoire d'Antibiologie, Unité UPRES EA 1156, Faculté de Médecine, and Laboratoire de Pharmacologie et de Toxicologie, CHU Nantes, France.
Caillon
Jocelyne
J
Gras-Le Guen
Christèle
C
Jacqueline
Cédric
C
Kergueris
Marie-France
MF
Granry
Jean-Claude
JC
Potel
Gilles
G
Bugnon
Denis
D
D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D019540:Area Under Curve; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D013293:Enterococcus faecalis; D005260:Female; D005839:Gentamicins / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006207:Half-Life; D011817:Rabbits
D000900:Anti-Bacterial Agents; D005839:Gentamicins