Anticaries efficacy of a new dentifrice for hypersensitivity.
OBJECTIVE
To evaluate the expected anticaries efficacy of a new dentifrice containing stannous fluoride as the anticaries agent and potassium nitrate as the antihypersensitivity agent using a series of laboratory and animal studies.


METHODS
Four surrogate studies were performed in this assessment including fluoride uptake in sound enamel, enamel solubility reduction, fluoride bioavailability and animal caries.


RESULTS
Each of these studies indicated the new dentifrice for hypersensitivity (Colgate Sensitive Maximum Strength) was effective in inhibiting the caries process. The data demonstrate that this new dentifrice is predicted to be highly effective against caries and equivalent to a positive control dentifrice.
Fisher
Steven W
SW
Colgate Oral Pharmaceuticals, Colgate-Palmolive Company, Piscataway, New Jersey 08855, USA. Steve_Fisher@colpal.com
Tavss
Edward A
EA
Gambogi
Robert J
RJ
Joziak
Marilou
M
D000134:Acid Etching, Dental; D016924:Actinomyces viscosus / Q000502:physiology; D000818:Animals; D001682:Biological Availability; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003731:Dental Caries / Q000382:microbiology / Q000517:prevention & control*; D003743:Dental Enamel / Q000187:drug effects; D003747:Dental Enamel Solubility / Q000187:drug effects; D003802:Dentifrices / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000517:prevention & control*; D004037:Diet, Cariogenic; D004195:Disease Models, Animal; D006801:Humans; D009566:Nitrates / Q000008:administration & dosage / Q000627:therapeutic use*; D017680:Potassium Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D016986:Streptococcus sobrinus / Q000502:physiology; D014002:Tin Fluorides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*
D002327:Cariostatic Agents; D003802:Dentifrices; D009566:Nitrates; D017680:Potassium Compounds; D014002:Tin Fluorides; C023844:potassium nitrate