HIS & HERS, magic magnesium and the ballet of protein synthesis.
The peptidyl transferase center of the ribosome is literally the mother of all protein enzymes, yet it was only recently that the content of its active site was found to be RNA and not protein. This review focuses on how this RNA enzyme orients its substrates and promotes the chemical reaction that is center stage in protein synthesis.
Parnell
K Mark
KM
Department of Molecular Biophysics and Biochemistry, Yale University, 260 Whitney Ave, New Haven, CT 06520-8114, USA.
Strobel
Scott A
SA
D002384:Catalysis; D004795:Enzyme Stability; D008274:Magnesium / Q000378:metabolism*; D015394:Molecular Structure; D010458:Peptidyl Transferases / Q000378:metabolism*; D014176:Protein Biosynthesis; D012335:RNA, Ribosomal / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism; D013379:Substrate Specificity
D012335:RNA, Ribosomal; D010458:Peptidyl Transferases; D008274:Magnesium