Levodopa pharmacokinetics and dyskinesias: are there sex-related differences?
We examined the potential sex-related differences in levodopa pharmacokinetics and their relation with the presence of dyskinesias in a group of 115 patients (67 men, 49 women) with Parkinson's disease. The patients were given a standard oral dose of levodopa plus benserazide (100/25 mg). The area under the levodopa plasma concentration time curve, corrected for the levodopa test dose (in mg/kg body weight), (AUC(w)) was significantly higher in women than in men, with a reduced oral clearance. No difference in the proportion of men and women experiencing dyskinesias was observed.
Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy.
P
P
Martinelli
M
M
Contin
C
C
Scaglione
R
R
Riva
F
F
Albani
A
A
Baruzzi
D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use; D019540:Area Under Curve; D001545:Benserazide / Q000627:therapeutic use; D016022:Case-Control Studies; D020820:Dyskinesias / Q000097:blood / Q000209:etiology*; D005260:Female; D006207:Half-Life; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000097:blood* / Q000627:therapeutic use; D016014:Linear Models; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood* / Q000188:drug therapy; D012727:Sex Characteristics
D000978:Antiparkinson Agents; D007980:Levodopa; D001545:Benserazide