Unipolar mania over the course of a 20-year follow-up study.
OBJECTIVE
Using data from a longitudinal study of the mood disorders, the investigators address the phenomenon of unipolar mania.


METHODS
Subjects diagnosed as having Research Diagnostic Criteria mania at intake into the study were prospectively followed for up to 20 years.


RESULTS
Twenty-seven subjects had the diagnosis of unipolar mania at the time they entered the study and had no history of major depression before enrolling in the study. Seven of these subjects did not suffer any episodes of major depression during the 15- to 20-year follow-up.


CONCLUSIONS
These data support the diagnostic validity of unipolar mania.
NIMH Collaborative Program on the Psychobiology of Depression-Clinical Studies, at Mood Disorders Program, Department of Psychiatry, Rhode Island Hospital, 593 Eddy Street, Providence. RI 02903-4970, USA. DASolomon@Lifespan.org
David A
DA
Solomon
Andrew C
AC
Leon
Jean
J
Endicott
William H
WH
Coryell
Timothy I
TI
Mueller
Michael A
MA
Posternak
Martin B
MB
Keller
D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011618:Psychotic Disorders / Q000175:diagnosis / Q000523:psychology; D015203:Reproducibility of Results