Metastatic ovarian Sertoli-cell tumor: FNA findings with immunohistochemistry.
A malignant Sertoli cell tumor of the ovary is a rare sex-cord stromal derived neoplasm. Sertoli cell tumors account for approximately 4% of Sertoli-stromal cell tumors (Hsu et al., J Histochem Cytochem 1981;29:577-580). The diagnosis of this entity by fine-needle aspiration and needle core biopsy can be difficult when the differential also includes a metastatic renal cell carcinoma, due to the overlap of both cytological and histological features. Here, we show that immunohistochemical staining on cytological material including alpha-inhibin can be used to differentiate between these two malignant tumors.
Department of Pathology and Immunology, The Lauren V. Ackerman Laboratory of Surgical Pathology, Washington University Medical School, St. Louis, Missouri, USA.
Brian
B
Watson
Cary L
CL
Siegel
Lourdes R
LR
Ylagan
D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D044963:Biopsy, Fine-Needle; D001943:Breast Neoplasms / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007265:Inhibins / Q000378:metabolism*; D007680:Kidney Neoplasms / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000473:pathology; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology*; D012707:Sertoli Cell Tumor / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor; C094377:inhibin-alpha subunit; D007265:Inhibins