Practical synthesis of sultams via sulfonamide dianion alkylation: application to the synthesis of chiral sultams.
[reaction: see text]. A practical synthesis of sultams was developed via intramolecular sulfonamide dianion alkylation. This method has been applied toward the synthesis of chiral sultams, which are synthetically valuable as chiral auxiliaries.
Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. jaemoon_lee@merck.com
Jaemoon
J
Lee
Yong-Li
YL
Zhong
Robert A
RA
Reamer
David
D
Askin