A role for rab7 GTPase in growth factor-regulated cell nutrition and apoptosis.
When growth factors are removed from many mammalian cells, growth ceases and apoptosis is induced. The small GTPase rab7, which regulates endocytic membrane traffic, participates in this process by mediating the regulated internalization and degradation of nutrient transporters. This process triggers nutrient starvation that helps to induce cell death.
Snider
Martin D
MD
Department of Biochemistry, Case Western Reserve School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002455:Cell Division / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D021381:Protein Transport / Q000502:physiology; D020691:rab GTP-Binding Proteins / Q000502:physiology*; D000090802:rab7 GTP-Binding Proteins
D006133:Growth Substances; D000090802:rab7 GTP-Binding Proteins; C000716463:rab7 GTP-binding proteins, human; D020691:rab GTP-Binding Proteins