Lateralized effects of subthalamic nucleus stimulation on different aspects of speech in Parkinson's disease.
In this report, we have analyzed the effects of left and right STN stimulation separately on different aspects of speech. Significant differences were found between left and right stimulation. It appears that selective left-sided stimulation has a profoundly negative effect on prosody, articulation and hence intelligibility. Right-sided stimulation does not display this side-effect. There is no significant difference in speech characteristics between bilateral stimulation on and off. We suggest that a balanced tuning of bilateral basal ganglia networks is necessary for speech, and that the left circuit is probably dominant.
Santens
Patrick
P
Department of Neurology, Ghent University Hospital, Belgium. patrick.santens@rug.ac.be
De Letter
Miet
M
Van Borsel
John
J
De Reuck
Jacques
J
Caemaert
Jacques
J
D000328:Adult; D000368:Aged; D001479:Basal Ganglia / Q000503:physiopathology; D004558:Electric Stimulation / Q000295:instrumentation; D004567:Electrodes, Implanted; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology; D010300:Parkinson Disease / Q000150:complications* / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D011182:Postoperative Care; D011300:Preoperative Care; D013064:Speech Disorders / Q000175:diagnosis* / Q000209:etiology*; D013065:Speech Intelligibility; D020531:Subthalamic Nucleus / Q000502:physiology*