Evaluation of alkali and alkaline earth metal cation selectivities of lariat ether amides by electrospray ionization mass spectrometry.
Lariat ethers with pendant amide groups have shown promise as new ion sensors because of their selectivity towards particular metal ions. In this study we report alkali and alkaline earth metal binding selectivities of dibenzo-16-crown-5 and fifteen dibenzo-16-crown-5 lariat ether amides (LEAs) as determined by electrospray ionization mass spectrometry (ESI-MS). Additionally, the influence of the acid/base nature of the solution on metal cation selectivity is investigated. The validity of using ESI-MS for determination of selectivities is established by analogous experiments using hosts with known binding constants for the same metal cations and solvent systems. Collisionally activated dissociation (CAD) is used to evaluate the influence of the alkali metal cation binding on the fragmentation of the LEAs.
Williams
Sheldon M
SM
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712-0165, USA.
Brodbelt
Jennifer S
JS
Bartsch
Richard A
RA