Characterization of diorganotin(IV) complexes with captopril. The first crystallographically authenticated metal complex of this anti-hypertensive agent.
Diorganotin(IV) complexes R(2)Sn(cap) (capH(2)=N-[(S)-3-mercapto-2-methylpropionyl]-L-proline; R=Me, Et, n-Bu and t-Bu) were prepared and characterised. The FTIR and Raman spectra demonstrated that the organotin(IV) moieties interact with the [S] atom of the ligand, while the other coordination sites are the carboxylate and the amide -CO groups. Mössbauer Delta data showed that the diorganotin(IV) compounds adopt slightly distorted trigonal-bipyramidal (tbp) geometry. A single-crystal X-ray study was performed on the compound Me(2)Sn(cap): the Sn atom is five-coordinated in a distorted tbp environment, with two [O] atoms in the axial positions and the [S] and two [C] atoms in the equatorial (eq) plane. Each cap ligand coordinates to two different Sn atoms, and infinite zigzag chains are formed, directed parallel to each other and to the b axis of the unit cell. NMR (CDCl(3)) of the Me(2)Sn(IV) and n-Bu(2)Sn(IV) complexes indicated the presence of different oligomeric species.
Biocoordination Research Group of Hungarian Academy of Sciences, Department of Inorganic and Analytical Chemistry, University of Szeged, P.O. Box 440, H-6701, Szeged, Hungary.
Hajnalka
H
Jankovics
Claudio
C
Pettinari
Fabio
F
Marchetti
Erzsébet
E
Kamu
László
L
Nagy
Sergei
S
Troyanov
Lorenzo
L
Pellerito
D000959:Antihypertensive Agents / Q000737:chemistry*; D002216:Captopril / Q000737:chemistry*; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008958:Models, Molecular; D009947:Organotin Compounds / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D015204:Spectroscopy, Mossbauer; D013059:Spectrum Analysis, Raman
D000959:Antihypertensive Agents; D009947:Organotin Compounds; D002216:Captopril