Renal tissue reconstitution by the implantation of renal segments on biodegradable polymer scaffolds.
Renal units were created in vivo by transplanting isolated renal segments on three-dimensional, biodegradable polymer scaffolds. Renal segments, freshly isolated from rat kidneys, were seeded on polymer scaffolds and subcutaneously implanted in athymic mice for two and four weeks. Three-dimensional renal reconstructs were formed with glomeruli and tubules, showing a possibility of reconstituting renal structures by transplanting renal segments.
Kim
Sang-Soo
SS
Department of Chemical Engineering, Hanyang University, Seoul, Korea.
Park
Heung Jae
HJ
Han
Joungho
J
Choi
Cha Yong
CY
Kim
Byung-Soo
BS
D020341:Absorbable Implants; D000818:Animals; D000831:Animals, Newborn; D002455:Cell Division / Q000502:physiology; D046508:Culture Techniques / Q000379:methods*; D005109:Extracellular Matrix / Q000502:physiology; D006085:Graft Survival / Q000502:physiology*; D007668:Kidney / Q000166:cytology* / Q000254:growth & development* / Q000601:surgery; D016030:Kidney Transplantation / Q000379:methods*; D008567:Membranes, Artificial; D011100:Polyglycolic Acid; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods*
D008567:Membranes, Artificial; D011100:Polyglycolic Acid