Leukoderma associated with Sézary syndrome: a rare presentation.
We describe a patient with Sézary syndrome who was initially seen with the rare occurrence of both generalized erythroderma and extensive leukoderma of his lower limbs. Apart from the absence of melanocytes in the leukodermic skin, histopathologic features of both areas were identical, showing an infiltrate of atypical lymphocytes with epidermotropism. This form of Sézary syndrome-associated leukoderma is clinically distinguishable from hypopigmented mycosis fungoides in which hypopigmented lesions are the sole manifestation of the cutaneous T-cell lymphoma.
Tang
Mark
M
National Skin Centre, Singapore.
Tan
Suat Hoon
SH
Lim
Lay Cheng
LC
D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D017496:Hypopigmentation / Q000209:etiology* / Q000473:pathology; D035002:Lower Extremity; D008297:Male; D010166:Palliative Care; D012751:Sezary Syndrome / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy; D012878:Skin Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy