Food habits are associated with lipid peroxidation in an elderly population.
OBJECTIVE
The purpose of this study was to assess the association between dietary intake and lipid peroxidation.


METHODS
Cross-sectional population analysis from an ongoing prospective study. Malondialdehyde (MDA) was measured as a marker of lipid peroxidation. Diet was assessed through direct observation and food frequency questionnaire.


METHODS
Participants with no missing data were 162 nonsmoking elderly individuals residing in 7 institutions across Asturias (Spain).


METHODS
Comparisons of adjusted group means by tertiles of plasma MDA were made by analysis of variance. Stepwise regression analysis was done using MDA as a dependent variable and food intake as an independent variable. Food intakes were categorized into quartiles and logistic regression was applied to calculate the odds ratio for being in the highest tertile of plasma MDA.


RESULTS
Consumption of potatoes had an independent direct effect and accounted for a sizeable proportion of the variation in plasma MDA levels (18%, P<.001). In addition to potatoes, other foods that had an apparently independent effect on plasma MDA were eggs, cooked vegetables, and red wine (R(2)=0.028, 0.023 and 0.018, respectively). In this study, dietary factors accounted for 25% of the variation in plasma MDA levels.


CONCLUSIONS
Identifying nutritional determinants of oxidative stress is important because of its negative health effect. Consumption of cooked vegetables and moderate intake of wine has been shown to be appropriate for reducing the risk of oxidative damage. On the contrary, caution must be used with the intake of potatoes because we have found a positive association with MDA levels. Further studies are required to investigate the mechanism(s) of this association and whether it is related to the preparation method or to the potato itself.
Departamento de Biología Funcional, Area de Fisiología, Facultad de Medicina, Universidad de Oviedo, Julián Clavería, s/n, Oviedo, Spain. lasheras@correo.uniovi.es
Cristina
C
Lasheras
Sonia
S
Gonzalez
Jose M
JM
Huerta
Clara
C
Lombardia
Raquel
R
Ibañez
Angeles M
AM
Patterson
Serafina
S
Fernandez
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000378:metabolism*; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D004032:Diet; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D016017:Odds Ratio; D018384:Oxidative Stress / Q000502:physiology*; D011446:Prospective Studies; D012044:Regression Analysis; D012307:Risk Factors; D011198:Solanum tuberosum; D013030:Spain; D011795:Surveys and Questionnaires; D014675:Vegetables; D014920:Wine
D000975:Antioxidants; D015415:Biomarkers; D008315:Malondialdehyde