The level of pre-heparin serum lipoprotein lipase mass at different stages of pregnancy.
BACKGROUND
Lipoprotein lipase (LPL) mass is present in pre-heparin serum, although its activity is rarely detected. To clarify the dynamics of pre-heparin LPL mass during pregnancy, we studied the relationship between pre-heparin LPL mass and lipids in normal pregnant women.


METHODS
Pre-heparin LPL mass and serum lipid levels were measured in 99 pregnant women during all three trimesters.


RESULTS
When compared with the first and second trimesters, a significant decrease in pre-heparin LPL mass was observed in the third trimester. Plasma triglycerides were negatively correlated with pre-heparin LPL mass (r=-0.30; p<0.05). In contrast, LDL-C, HDL-C and total cholesterol did not exhibit a statistically significant correlation.


CONCLUSIONS
The decrease in pre-heparin LPL mass is manifested only during the third trimester.
Kinoshita
Toshihiko
T
Department of Obstetrics and Gynecology, Sakura Hospital, Toho University School of Medicine, 564-1 Shimoshizu, Sakura City, Chiba 285-8741, Japan. kino@sakura.med.toho0u.ac.jp
Shirai
Kohji
K
Itoh
Motohiro
M
D000704:Analysis of Variance; D002352:Carrier Proteins / Q000097:blood; D002784:Cholesterol / Q000097:blood; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D007774:Lactation / Q000097:blood; D008071:Lipoprotein Lipase / Q000097:blood*; D049590:Postpartum Period / Q000097:blood*; D011247:Pregnancy; D011264:Pregnancy Trimesters / Q000097:blood*; D014280:Triglycerides / Q000097:blood
C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006023:Glycoproteins; D014280:Triglycerides; D002784:Cholesterol; D008071:Lipoprotein Lipase