Gadolinium-binding helix-turn-helix peptides: DNA-dependent MRI contrast agents.
A de novo designed gadolinium metallopeptide was found to be a very efficient relaxation agent, with 100% increase in relaxivity upon binding to DNA.
EPIX Medical, Inc., 71 Rogers Street, Cambridge, MA 02142, USA.
Peter
P
Caravan
Jaclyn M
JM
Greenwood
Joel T
JT
Welch
Sonya J
SJ
Franklin
D000595:Amino Acid Sequence; D002614:Chelating Agents / Q000737:chemistry / Q000378:metabolism; D003287:Contrast Media / Q000737:chemistry*; D004247:DNA / Q000378:metabolism*; D015195:Drug Design; D005682:Gadolinium / Q000737:chemistry*; D019786:Gadolinium DTPA; D019077:Helix-Turn-Helix Motifs; D008279:Magnetic Resonance Imaging; D008667:Metalloproteins / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009942:Organometallic Compounds / Q000737:chemistry / Q000378:metabolism; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D019047:Phantoms, Imaging
D002614:Chelating Agents; D003287:Contrast Media; D008667:Metalloproteins; D009942:Organometallic Compounds; D010455:Peptides; D004247:DNA; D005682:Gadolinium; D019786:Gadolinium DTPA