Safe and successful endoarterial infusion of liposomal amphotericin B in treatment of mucormycosis.
Mucormycosis is a rare invasive mycotic infection treated by antifungini or amphotericin B. We describe the case of a patient with septic fever and a necrotic lesion, with phlegmon of medial left thigh. Surgery was performed to drain the abscess content and to remove the necrotic tissue; mucormycosis was diagnosized by histological and culture tests and treated by intravenous amphotericin B. Since the lesion worsened, liposomal amphotericin B was directly infused into the left common iliac artery, with progressive improvement, and treatment was continued until complete recovery. Therefore, the endoarterial infusion of liposomal amphotericin B was a safe and successful treatment of advanced lesions of mucormycosis. In such lesions, intravenous general antibiotic administration probably is not sufficient to reach the whole infected area.
Mansueto
P
P
Department of Clinical Medicine and Emerging Diseases, University of Palermo, Italy.
Rizzo
M
M
Affronti
M
M
Malta
R
R
Carmina
E
E
Mansueto
S
S
Masellis
M
M
Rini
G B
GB
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D003937:Diagnosis, Differential; D006801:Humans; D007261:Infusions, Intra-Arterial; D008081:Liposomes / Q000008:administration & dosage; D008297:Male; D009091:Mucormycosis / Q000175:diagnosis / Q000188:drug therapy*
D000935:Antifungal Agents; D008081:Liposomes; D000666:Amphotericin B