Association of tau gene polymorphism with Parkinson's disease.
We investigated the segregation of the dinucleotide GT repeat polymorphism in the intron between exons 9 and 10 of the tau gene in 300 patients with Parkinson's disease (PD) and in 197 normal controls. The A3 allele was more frequent in cases than in controls (30% versus 16%, p<0.001), and individuals carrying at least one A3 allele in their genotype had an increased risk of developing PD (odds ratio 2.78, 95% confidence interval 1.81-4.29). No significant differences were found between patients by considering the age at onset and the presence of family history or dementia. Our findings suggest a possible involvement of the tau gene in the pathogenesis of PD.
Clinica Neurologica, Università di Catanzaro, Via Campanella, Catanzaro, Italy.
M
M
Zappia
G
G
Annesi
G
G
Nicoletti
P
P
Serra
G
G
Arabia
P
P
Pugliese
D
D
Messina
M
M
Caracciolo
N
N
Romeo
F
F
Annesi
A A
AA
Pasqua
P
P
Spadafora
D
D
Civitelli
N
N
Romeo
A
A
Epifanio
L
L
Morgante
A
A
Quattrone
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D018900:Dinucleotide Repeats; D005091:Exons; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D023281:Genomics; D006801:Humans; D007438:Introns; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D016875:tau Proteins / Q000235:genetics*
D016875:tau Proteins