Post-weaning social isolation of rats leads to a diminution of LTP in the CA1 to subiculum pathway.
Post-weaning social isolation of rats produces psychological and physiological changes that are relevant to schizophrenia. Here, we report that long-term potentiation (LTP) in the CA1 to subiculum pathway is lower by 34%, (P<0.0001) in brain slices from isolates compared with those from socially housed rats. We also report that LTP in this pathway is NMDA receptor-dependent.
Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK. l.roberts@bristol.ac.uk
L
L
Roberts
J R T
JR
Greene
D000818:Animals; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D009924:Organ Culture Techniques; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D012934:Social Isolation; D014886:Weaning
D016194:Receptors, N-Methyl-D-Aspartate