Growth, growth velocity and adult height in Mexican girls with Turner's syndrome.
This was a prospective, longitudinal and descriptive study of 117 Mexican girls with Turner's syndrome (TS) followed from diagnosis to 18 years old. Height, weight and growth velocity were evaluated every 4-6 months, and bone age was assessed annually. Adult height was reached in 87 girls. All the girls were treated during 1 year with conjugated estrogens at bone age of 12 years, and subsequently with mixed estrogen/progestogen. Growth retardation in girls with TS is apparent at birth (2.7 +/- 0.9 kg and 46.3 +/- 5.0 cm) and in childhood, but becomes most marked when puberty would normally occur. Mean growth velocity was less than 25th percentile from birth to 2 years, less than 10th percentile between 3-9 years, and less than 3rd percentile from 10 to 18 years of age. Final adult height was 136.9 +/- 5.5 cm, but it is affected by the particular karyotype: 46,Xi(Xq): 134.5 cm, 45,XO: 137.3 cm, and 45XO/46,XX: 139 cm.
Robles Valdés
Carlos
C
Medical Speciality Department, Instituto Nacional de Pediatria, México D.F., México.
del Castillo Ruiz
Victoria
V
Oyoqui
Joel
J
Altamirano Bustamante
Nelly
N
de la Luz Ruiz Reyes
María
M
Calzada León
Raúl
R
D000365:Age Determination by Skeleton / Q000379:methods; D001827:Body Height / Q000187:drug effects / Q000208:ethnology* / Q000235:genetics*; D041321:Chromosomes, Human, X / Q000235:genetics; D015331:Cohort Studies; D004334:Drug Administration Schedule; D004967:Estrogens / Q000627:therapeutic use; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use; D005260:Female; D005317:Fetal Growth Retardation / Q000208:ethnology / Q000235:genetics; D006128:Growth / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008800:Mexico; D011374:Progesterone / Q000627:therapeutic use; D011627:Puberty / Q000235:genetics; D012729:Sex Chromosome Aberrations / Q000706:statistics & numerical data; D012959:Socioeconomic Factors; D014424:Turner Syndrome / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology*
D004967:Estrogens; D004966:Estrogens, Conjugated (USP); D011374:Progesterone