Annular epidermolytic ichthyosis.
A 21-year-old woman presented to the Charles C. Harris Skin and Cancer Pavilion with a life-long history of palmoplantar keratoderma that was accompanied by episodic flares of polycyclic psoriasiform patches diffusely over the rest of her body. A biopsy specimen of a representative skin lesion showed epidermolytic hyperkeratosis. The particular phenotype that this patient exhibited has been reported in only seven families previously in the literature. Mutations in keratin 1 and 10 have been identified in these patients and are similar to those mutations in patients with classic epidermolytic hyperkeratosis.
Ronald O. Perelman Department of Dermatology, New York University, USA.
Narayan S
NS
Naik
D000328:Adult; D005260:Female; D006801:Humans; D017488:Hyperkeratosis, Epidermolytic / Q000235:genetics / Q000473:pathology; D007633:Keratins / Q000235:genetics; D010641:Phenotype
D007633:Keratins