[In vivo effect of Shu-Gan-Liang-Xue decoction on estrogen].
OBJECTIVE
To observe the in vivo effect of traditional chinese medicine (TCM) Shu-Gan-Liang-Xue (SGLX) decoction on estrogen in vivo in mice.


METHODS
Mice were randomly divided into control, tamoxifen (TAM), SGLX and SGLX + TAM groups. After SGLX decoction had been given to mice for 21 days, the serum hormone level of mice was tested by radioimmunological method, uterine weight index was obtained by uterine weight divided by body weight. Endometrial change was pathologically observed.


RESULTS
SGLX decoction reduced the level of serum estrogen more than the control with significant difference (P < 0.001). Uterine weight index was more lowered in the SGLX group than the control giving a difference but not significant. The endometrium in the SGLX group showed no change when compared with that of the control, but the SGLX + TAM group showed slightly more endometrial hyperplasia than the TAM group.


CONCLUSIONS
SGLX decoction, having synergistic effect on TAM, can reduce serum hormone level and alleviate the endometrial hypertrophy side effect of TAM.
Department of Traditional Chinese Medicine, Beijing Cancer Hospital, Beijing Institute for Cancer Research, Peking University School of Oncology, Beijing 100036, China.
Ping-ping
PP
Li
Wei
W
Wang
Yu-quan
YQ
Xie
D000818:Animals; D004357:Drug Synergism; D004717:Endometrium / Q000187:drug effects / Q000473:pathology; D004967:Estrogens / Q000097:blood*; D005260:Female; D008516:Medicine, Chinese Traditional; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D013629:Tamoxifen / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects
D004967:Estrogens; D013629:Tamoxifen