A genome-wide screen for association in Hungarian multiple sclerosis.
Although the pathogenesis of multiple sclerosis (MS) is not fully understood, substantial evidence points to the involvement of genetic factors. We report on a genome-wide screen for disease association in the Hungarian population using 5532 microsatellite markers. These markers were typed in DNA pools that consisted of 88 MS patients (cases), and 128 unrelated controls. Based on a stringent selection criterion, we obtained 33 markers suggesting association with the disease.
Department of Neurology, University of Szeged, Semmelweis u. 6, H-6725 Szeged, Hungary.
Cecilia
C
Rajda
Krisztina
K
Bencsik
Erika
E
Seres
Aslaug
A
Jonasdottir
Thomas
T
Foltynie
Stephen
S
Sawcer
Kjartan
K
Benediktsson
Ragnheidur
R
Fossdal
Efrosini
E
Setakis
Alastair
A
Compston
László
L
Vécsei
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods* / Q000706:statistics & numerical data; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007391:International Cooperation; D008297:Male; D018895:Microsatellite Repeats; D016133:Polymerase Chain Reaction; D012984:Software