Synthesis of marine guanidine alkaloids and their application as chemical/biological tools.
Ptilomycalin A and crambescidins, novel marine guanidine alkaloids, have a unique pentacyclic guanidine structure, and exhibit a considerable array of biological activities. The first method developed for the synthesis of the pentacyclic guanidine core structure involved successive 1,3-dipolar cycloaddition reactions and resulted in the first total synthesis of crambescidin 359. The synthesis of other pentacyclic guanidine derivatives has been based on this methodology and applied as tools for studying biological activities, and as chemical reaction catalysts.
Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Kazuo
K
Nagasawa
Yuichi
Y
Hashimoto
D000470:Alkaloids / Q000138:chemical synthesis*; D002384:Catalysis; D019791:Guanidine / Q000138:chemical synthesis*; D008386:Marine Biology
D000470:Alkaloids; D019791:Guanidine