Annularins A-H: new polyketide metabolites from the freshwater aquatic fungus Annulatascus triseptatus.
Eight new polyketide metabolites, annularins A-H (1-8), along with the known compound (-)-(S)-p-hydroxyphenyllactic acid, were isolated from the organic extracts of the freshwater fungus Annulatascus triseptatus. Compounds 1-6 are 3,4,5-trisubstituted alpha-pyrones, and the fused bicyclic pyrone-furanone system in annularin F (6) has not been reported previously among natural products. Compounds 7 and 8 are 3,4-disubstituted alpha,beta-unsaturated gamma-lactones. Annularins A (1), B (2), C (3), and F (6) exhibited antibacterial activity.
Department of Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
Chen
C
Li
Meaghan V
MV
Nitka
James B
JB
Gloer
Jinx
J
Campbell
Carol A
CA
Shearer
D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008281:Maine; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020037:Sordariales / Q000737:chemistry*; D013237:Stereoisomerism
D000890:Anti-Infective Agents; D011753:Pyrones