N-functionalization of poly(ethylene glycol)-linked mono- and bis-dioxocyclams as potential ligands for Gd3+.
A number of highly functionalized dioxocyclams with acetic acid side chains on the secondary amine sites and ethylene glycol side chains on 6 and 13-positions (12a, 12b) or a tetra(ethylene glycol) side chain linking the 6 and 13 positions (15) were synthesized and characterized, as was a bis-dioxocyclam bridged across the 6 and 13 positions by tetra(ethylene glycol) groups (16). These were screened for their ability to complex Gd3+. Only ligands 15 and 16, having tetra(ethylene glycol) groups, formed such complexes.
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
Todd A
TA
Brugel
L S
LS
Hegedus
D000107:Acetylation; D002412:Cations; D018360:Crystallography, X-Ray; D004952:Esters / Q000138:chemical synthesis; D005682:Gadolinium / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D008024:Ligands; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis; D011092:Polyethylene Glycols / Q000737:chemistry*
D002412:Cations; D004952:Esters; D006571:Heterocyclic Compounds; D008024:Ligands; D009942:Organometallic Compounds; D011092:Polyethylene Glycols; C034036:dioxocyclam; D005682:Gadolinium