Angiographic regression of cardiac allograft vasculopathy after introducing sirolimus immunosuppression.
We describe a 33-year-old heart transplant recipient who experienced several episodes of early Grade IIIA rejection and aggressive allograft vasculopathy, seen with serial coronary angiography. Two years after transplantation, we added sirolimus therapy to the patient's immunosuppressive regimen, and a further coronary angiogram 1 year later showed regression of the graft vasculopathy.
Ruygrok
Peter N
PN
Cardiology Department, Green Lane Hospital, Auckland, New Zealand. pruygrok@adhb.govt.nz
Webber
Bruce
B
Faddy
Stephen
S
Muller
David W
DW
Keogh
Anne
A
D000328:Adult; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006084:Graft Rejection / Q000188:drug therapy*; D016027:Heart Transplantation / Q000009:adverse effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D020123:Sirolimus / Q000627:therapeutic use*; D017741:Survivors; D014184:Transplantation, Homologous / Q000009:adverse effects
D007166:Immunosuppressive Agents; D020123:Sirolimus