Increased density of human immunodeficiency virus type 1 coreceptors CCR5 and CXCR4 on the surfaces of CD4(+) T cells and monocytes of patients with Schistosoma mansoni infection.
Distribution of chemokine receptors CCR5 and CXCR4, which are also coreceptors for human immunodeficiency virus type 1 invasion of cells, was measured on the surfaces of CD4(+) T cells and monocytes in peripheral blood samples from a group of Kenyan car washers. Patients with active schistosomiasis displayed higher cell surface densities of these receptors than did cured schistosomiasis patients.
Secor
W Evan
WE
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341, USA. was4@cdc.gov
Shah
Amil
A
Mwinzi
Pauline M N
PM
Ndenga
Bryson A
BA
Watta
Caroline O
CO
Karanja
Diana M S
DM
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology*; D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry*; D015497:HIV-1; D006801:Humans; D019713:Receptors, CCR5 / Q000032:analysis*; D019718:Receptors, CXCR4 / Q000032:analysis*; D012555:Schistosomiasis mansoni / Q000276:immunology*
D019713:Receptors, CCR5; D019718:Receptors, CXCR4