The first silver-catalyzed three-component coupling of aldehyde, alkyne, and amine.
[reaction: see text] Silver iodide catalyzed the three-component coupling of aldehyde, alkyne, and amines to generate propargylic amines with high efficiency in water. The silver-catalyzed reaction is especially effective for reactions involving aliphatic aldehyde. No additional cocatalyst or activator is required.
Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA.
Chunmei
C
Wei
Zigang
Z
Li
Chao-Jun
CJ
Li