[Hypersensitive reaction to abacavir or syphilitic hepatitis?].
BACKGROUND
Syphilis remains a current infection in France, with an increase in cases associated with the increase in sexual practices at risk.


METHODS
An HIV-seropositive homosexual male presented with a perturbed hepatic profile and roseola-like exanthema 15 days after starting treatment with Trizivir. Because of the combination of hepatitis and cutaneous eruption evoking hypersensitivity to abacavir, treatment was suspended, but no improvement was noted. The diagnosis of syphilitic hepatitis associated with roseola was made following a sero-conversion and improvement was obtained with benzathine-penicillin and the re-introduction of Trizivir without further problem.


CONCLUSIONS
This case report underlines the possibility of discovering syphilis when confronted with cholestatic and cytolytic hepatitis that regresses with penicillin and is isolated or associated with evocative cutaneous signs.
Service de médecine interne et des maladies infectieuses, Hôpital de Fleyriat, Bourg-en-Bresse.
Hélène
H
Dumouchel-Champagne
Damien
D
Bouhour
Tristan
T
Ferry
François
F
Durupt
Philippe
P
Granier
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000209:etiology*; D015224:Dideoxynucleosides / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005029:Ethylenediamines / Q000627:therapeutic use; D006679:HIV Seropositivity / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D019259:Lamivudine / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D013587:Syphilis / Q000175:diagnosis* / Q000188:drug therapy; D015215:Zidovudine / Q000009:adverse effects / Q000627:therapeutic use*; D000099227:Abacavir
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D004338:Drug Combinations; D005029:Ethylenediamines; D019259:Lamivudine; D015215:Zidovudine; D000099227:Abacavir; C418262:abacavir, lamivudine, and zidovudine drug combination; C010044:benzathine