S-nitrosylation of NSF controls membrane trafficking.
Nitric oxide is a diffusible molecule with profound effects on regulated exocytosis in several biological systems-however, the molecular targets remain elusive. In this issue of Cell, Matsushita et al. report that in aortic endothelial cells, S-nitrosylation of NSF, an ATPase essential for the activation of the membranefusion machinery, inhibits the exocytosis of Weibel-Palade bodies, secretory granules containing a cocktail of mediators essential to the regulation of vascular vessel tone.
Memorial Sloan-Kettering Cancer Center, Cellular Biochemistry & Biophysics Program, New York, NY 10021, USA.
Thomas H
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Söllner
Sonia
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Sequeira
D000595:Amino Acid Sequence; D001011:Aorta / Q000166:cytology; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D002478:Cells, Cultured; D017124:Conserved Sequence; D003545:Cysteine / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D005089:Exocytosis; D006801:Humans; D008969:Molecular Sequence Data; D052066:N-Ethylmaleimide-Sensitive Proteins; D009569:Nitric Oxide / Q000096:biosynthesis / Q000494:pharmacology*; D033921:Vesicular Transport Proteins; D020302:Weibel-Palade Bodies / Q000378:metabolism
D002352:Carrier Proteins; D033921:Vesicular Transport Proteins; D009569:Nitric Oxide; D052066:N-Ethylmaleimide-Sensitive Proteins; D003545:Cysteine