The universal dynamics of tumor growth.
Scaling techniques were used to analyze the fractal nature of colonies of 15 cell lines growing in vitro as well as of 16 types of tumor developing in vivo. All cell colonies were found to exhibit exactly the same growth dynamics-which correspond to the molecular beam epitaxy (MBE) universality class. MBE dynamics are characterized by 1), a linear growth rate, 2), the constraint of cell proliferation to the colony/tumor border, and 3), surface diffusion of cells at the growing edge. These characteristics were experimentally verified in the studied colonies. That these should show MBE dynamics is in strong contrast with the currently established concept of tumor growth: the kinetics of this type of proliferation rules out exponential or Gompertzian growth. Rather, a clear linear growth regime is followed. The importance of new cell movements-cell diffusion at the tumor border-lies in the fact that tumor growth must be conceived as a competition for space between the tumor and the host, and not for nutrients or other factors. Strong experimental evidence is presented for 16 types of tumor, the growth of which cell surface diffusion may be the main mechanism responsible in vivo. These results explain most of the clinical and biological features of colonies and tumors, offer new theoretical frameworks, and challenge the wisdom of some current clinical strategies.
CCMA, Consejo Superior de Investigaciones Científicas, 28006 Madrid, Spain. antonio.bru@ccma.csic.es
Antonio
A
Brú
Sonia
S
Albertos
José
J
Luis Subiza
José López
JL
García-Asenjo
Isabel
I
Brú
D000818:Animals; D002449:Cell Aggregation; D002452:Cell Count / Q000379:methods*; D002455:Cell Division; D045744:Cell Line, Tumor; D002465:Cell Movement; D003198:Computer Simulation; D017709:Fractals; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D016014:Linear Models; D008954:Models, Biological; D009369:Neoplasms / Q000145:classification / Q000473:pathology* / Q000503:physiopathology*