Cascade cyclizations and couplings involving nickel enolates.
A new strategy for effecting cascade cyclization processes using nickel enolates has been developed. Nickel enolates may be cleanly generated by the oxidative cyclization of an enal and alkyne with Ni(0), and the resulting enolate may be functionalized by a variety of alkylation processes. Partially and fully intramolecular versions of the process allow the rapid synthesis of complex polycyclics from simple achiral, acyclic precursors.
Mahandru
Gireesh M
GM
Department of Chemistry, Wayne State University, Detroit, Michigan 48202-3489, USA.
Skauge
Andy R L
AR
Chowdhury
Sanjoy K
SK
Amarasinghe
Kande K D
KK
Heeg
Mary Jane
MJ
Montgomery
John
J