Angiographic regression of cardiac allograft vasculopathy after introducing sirolimus immunosuppression.
We describe a 33-year-old heart transplant recipient who experienced several episodes of early Grade IIIA rejection and aggressive allograft vasculopathy, seen with serial coronary angiography. Two years after transplantation, we added sirolimus therapy to the patient's immunosuppressive regimen, and a further coronary angiogram 1 year later showed regression of the graft vasculopathy.
Cardiology Department, Green Lane Hospital, Auckland, New Zealand. pruygrok@adhb.govt.nz
Peter N
PN
Ruygrok
Bruce
B
Webber
Stephen
S
Faddy
David W
DW
Muller
Anne
A
Keogh
D000328:Adult; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006084:Graft Rejection / Q000188:drug therapy*; D016027:Heart Transplantation / Q000009:adverse effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D020123:Sirolimus / Q000627:therapeutic use*; D017741:Survivors; D014184:Transplantation, Homologous / Q000009:adverse effects
D007166:Immunosuppressive Agents; D020123:Sirolimus