Impact of body mass index on fasting blood glucose concentration among Helicobater pylori carriers.
OBJECTIVE
Despite the fact that Helicobacter pylori (Hp) is regarded as a major gastroduodenal pathogen, it has recently been suggested to be an important factor for non-gastroenterologic conditions such as diabetes mellitus. Accordingly, it seems that Hp infection may have implications in glycemic control and in fasting plasma glucose concentrations. As overnutrition and obesity are directly related to impaired glucose tolerance, the aim of the present study was to determine whether Hp infection leads to alterations in fasting plasma glucose concentrations of Hp carriers and especially in relation to their body mass index.


METHODS
Serum was obtained from 224 young, male navy recruits. An enzyme-linked immunosorbent assay to detect Hp-specific IgG serum antibodies as well as gastroscopy along with biopsy was used to identify the infected individuals. Serum levels of glucose, urea, creatinine and uric acid were also determined. Non-fasting subjects and persons with abnormal oral glucose tolerance curve test were excluded.


RESULTS
Among Hp-positive individuals, obese persons presented with a significantly lower mean blood glucose level than non-obese persons. Obese Hp-contaminated participants had significantly lower mean fasting blood glucose concentrations as well as a significantly smaller percentage of participants with abnormal elevated blood glucose levels than obese participants negative to Hp infection.


CONCLUSIONS
Our data suggest that obesity in combination with Hp infection may induce an enhanced response to insulin leading to reduced fasting blood glucose levels, among Hp-positive obese persons in comparison to Hp-positive lean persons.
Kyriazanos
Ioannis D
ID
2nd Department of Surgery, Naval Hospital of Athens, Athens, Greece. medkyri@yahoo.com
Sfiniadakis
Ioannis
I
Dimakos
Panagiotis
P
Gizaris
Vasilios
V
Datsakis
Konstantinos
K
Dafnopoulou
Aggeliki
A
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D004797:Enzyme-Linked Immunosorbent Assay; D005215:Fasting / Q000097:blood; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000097:blood* / Q000150:complications; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D008297:Male; D008889:Military Personnel; D009765:Obesity / Q000097:blood* / Q000150:complications; D012307:Risk Factors
D000907:Antibodies, Bacterial; D001786:Blood Glucose