Synthesis of the integrastatin nucleus using the Ramberg-Bäcklund reaction.
[reaction: see text] The first synthesis of the tetracyclic nucleus of the Integrastatins, natural products that have been shown to selectively inhibit HIV-1 integrase, is reported. Key steps of this synthesis involve a novel cis-selective Ramberg-Bäcklund reaction and an unusual Lewis acid-promoted cyclization step.
Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
Jonathan S
JS
Foot
Gerard M P
GM
Giblin
Richard J K
RJ
Taylor