The variable number of tandem repeat polymorphism of platelet glycoprotein Ibalpha and risk of coronary heart disease.
Glycoprotein (GP) Ib-IX-V complex plays an important role in formation of platelet-fibrin clot at the area of damaged vessel wall. One polymorphism of GP Ibalpha, the main component of GP Ib-IX-V complex, is due to variable numbers of tandem repeats (VNTRs) in the macroglycopeptide region of this molecule. We studied the association between the presence of different VNTR alleles of GP Ibalpha and the frequency of coronary heart disease (CHD) among individuals recruited to a large community-based case-cohort study (Atherosclerosis Risk in Communities [ARIC] study). We found that the distribution of VNTR alleles of GP Ibalpha is different among whites and African Americans. The B allele (with 3 repeats) of GP Ibalpha is relatively more common among African Americans compared with whites. In African Americans, the CC genotype (homozygous with 2 repeats) is associated with a lower risk of CHD events than all other genotypes.
Thrombosis Research Section, Department of Medicine, BCM 286, N1319, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Vahid
V
Afshar-Kharghan
Nevenka
N
Matijevic-Aleksic
Chul
C
Ahn
Eric
E
Boerwinkle
Kenneth K
KK
Wu
José A
JA
López
D000483:Alleles; D044383:Black People / Q000235:genetics; D015331:Cohort Studies; D003327:Coronary Disease / Q000097:blood / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000235:genetics*; D012307:Risk Factors; D044465:White People / Q000235:genetics; D001741:Black or African American
D019038:Platelet Glycoprotein GPIb-IX Complex