[Quantitative pathologic technique in prognostic identification of breast carcinoma with negative lymph node].
OBJECTIVE
To study the prognostic identification of lymph node negative breast carcinoma by quantitative pathologic technique.


METHODS
Several morphometrical parameters, DNA content of cell nuclei were detected by means of a quantitative pathologic technique on 102 patients with lymph node negative invasive breast duct carcinoma. The effects of potential prognostic factors of lymph node negative breast cancer patients were assessed by Cox's proportional hazards regression model.


RESULTS
DNA index, minimal diameter of nuclei, area of nuclei, maximal diameter of nuclei, and the perimeter of nuclei are important factors to influence the prognosis.


CONCLUSIONS
Quantitative pathologic technique combined with valid statistical methods, as an objective means of assessing prognosis, may reliably improve the outcome in lymph node negative breast cancer.
Department of General Surgery, Mianyang Central Hospital, Mianyang 621000, China.
Wei-yun
WY
Xu
Li
L
Chen
Sheng
S
He
Yun-chun
YC
Li
Yong-hong
YH
Yang
An-qun
AQ
Wang
Gang
G
Xie
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis
D004273:DNA, Neoplasm