O-mannosyl glycans: from yeast to novel associations with human disease.
In yeasts and other fungi, O-mannosyl glycans constitute a major protein modification that is essential for cell viability. For several decades, protein O-mannosylation was considered a yeast-specific modification. Thus, it was especially interesting when it became evident that O-mannosyl glycans in mammals are not as rare as previously thought. O-mannosyl glycans are abundant in the mammalian brain and are also an abundant modification of alpha-dystroglycan, a component of the dystrophin-glycoprotein complex. Recently, mutations in genes that are or might be involved in the glycosylation of alpha-dystroglycan have been identified. Their association with neuromuscular diseases has focused the attention of different research areas on protein O-mannosylation.
Willer
Tobias
T
Lehrstuhl für Zellbiologie und Pflanzenphysiologie, Universität Regensburg, 93040, Regensburg, Germany.
Valero
M Carmen
MC
Tanner
Widmar
W
Cruces
Jesus
J
Strahl
Sabine
S
D000818:Animals; D006023:Glycoproteins / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008322:Mammals; D008358:Mannose / Q000737:chemistry / Q000378:metabolism; D008364:Mannosyltransferases / Q000737:chemistry / Q000378:metabolism; D008968:Molecular Conformation; D015394:Molecular Structure; D009136:Muscular Dystrophies / Q000378:metabolism*; D011134:Polysaccharides / Q000737:chemistry* / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000378:metabolism; D013045:Species Specificity; D013329:Structure-Activity Relationship; D015003:Yeasts / Q000737:chemistry* / Q000378:metabolism*
D006023:Glycoproteins; D011134:Polysaccharides; D008364:Mannosyltransferases; C082696:protein O-mannosyltransferase; D008358:Mannose