Rickets caused by excessive renal phosphate loss and apparent abnormal vitamin D metabolism in a cat.
Rickets was diagnosed in a 1-year-old cat with a history of weakness, osteopenia, and recurrent fractures. Processes causing rickets include vitamin D deficiency caused by inadequate, nutrition, lack of exposure to sunlight, defective metabolism of parent vitamin D to active metabolites, inherited vitamin D receptor defects, hypoparathyroidism, chronic renal failure, renal loss of phosphate, or malabsorptive states resulting from gastrointestinal or hepatic diseases. On the basis of analysis of serum 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D2 and D3 concentrations, serum biochemical analysis, and urinary fractional clearance of electrolytes, the causes of rickets in our cat, were most compatible with a combination of excessive loss of phosphorus via the kidneys and deficient or abnormal hepatic 25-hydroxylation of vitamin D. Calcifediol treatment and twice daily administration of phosphate salts resulted in clinical improvement and increases in mineralization of the skeleton, as evidenced on radiographic evaluation.
Henik
R A
RA
Department of Medical Sciences, University of Wisconsin, Madison, WI 53706, USA.
Forrest
L J
LJ
Friedman
A L
AL
D000818:Animals; D002112:Calcifediol / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D002117:Calcitriol / Q000097:blood; D002371:Cat Diseases / Q000188:drug therapy / Q000378:metabolism*; D002415:Cats; D004872:Ergocalciferols / Q000097:blood; D005260:Female; D007668:Kidney / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism* / Q000652:urine; D012016:Reference Values; D012279:Rickets / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D014807:Vitamin D / Q000378:metabolism*; D014808:Vitamin D Deficiency / Q000378:metabolism
D004872:Ergocalciferols; D010710:Phosphates; D014807:Vitamin D; C003564:1,25-dihydroxyergocalciferol; D002117:Calcitriol; D002112:Calcifediol