The effects of the loop diuretics furosemide and torasemide on diuresis in dogs and cats.
Torasemide is a new loop diuretic that combines the effects of furosemide and spironolactone. There are no reports on the effects of torasemide in cats and dogs. This study compared the diuretic effects of furosemide and torasemide in cats and dogs. Cats with pressure overload cardiac hypertrophy were given oral placebo, torasemide 0.3 mg/kg, or furosemide 1 mg/kg or 3 mg/kg. Control and mitral regurgitation dogs were given oral placebo, torasemide 0.2 mg/kg, and furosemide 2 mg/kg for 7 days. Urine samples were obtained at baseline and 1, 2, 3, 4, 5, 6, 8, 12, and 24 hr after each drug dose. Urine volume and urine Na(+) and K(+) were measured. Both furosemide and torasemide increased urine volume 1 hr after administration. Furosemide caused a dose-dependent increase in urine volume that peaked at 2-3 hr in cats and dogs. The diuretic effect of furosemide disappeared 6 hr after administration, while that of torasemide peaked 2-4 hr after administration and persisted for 12 hr in cats and dogs. In MR dogs, torasemide for 7 days significantly decreased urine potassium excretion. Plasma aldosterone increased with torasemide, whereas there was no change with furosemide. In conclusion, about 1/10 concentration of torasemide was as potent as furosemide and had a longer diuretic effect in cats and dogs. These data suggest that torasemide is useful for treating congestive heart failure or edema in cats and dogs.
Uechi
Masami
M
Veterinary Teaching Hospital, Kitasato University Higashi, Towada, Aomori, Japan.
Matsuoka
Mika
M
Kuwajima
Emi
E
Kaneko
Tomonari
T
Yamashita
Kazushi
K
Fukushima
Ushio
U
Ishikawa
Yumi
Y
D000818:Animals; D002415:Cats; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology; D004285:Dogs; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D008297:Male; D012016:Reference Values; D013449:Sulfonamides / Q000494:pharmacology*; D013997:Time Factors; D000077786:Torsemide
D004232:Diuretics; D013449:Sulfonamides; D005665:Furosemide; D000077786:Torsemide