Minimum alveolar concentration of sevoflurane in spontaneously breathing llamas and alpacas.
OBJECTIVE
To determine the minimum alveolar concentration (MAC) of sevoflurane in spontaneously breathing llamas and alpacas.


METHODS
Prospective study.


METHODS
6 healthy adult llamas and 6 healthy adult alpacas.


METHODS
Anesthesia was induced with sevoflurane delivered with oxygen through a mask. An endotracheal tube was inserted, and a port for continuous measurement of end-tidal and inspired sevoflurane concentrations was placed between the endotracheal tube and the breathing circuit. After equilibration at an end-tidal-to-inspired sevoflurane concentration ratio > 0.90 for 15 minutes, a 50-Hz, 80-mA electrical stimulus was applied to the antebrachium until a response was obtained (ie, gross purposeful movement) or for up to 1 minute. The vaporizer setting was increased or decreased to effect a 10 to 20% change in end-tidal sevoflurane concentration, and equilibration and stimulus were repeated. The MAC was defined as the mean of the lowest end-tidal sevoflurane concentration that prevented a positive response and the highest concentration that allowed a positive response.


RESULTS
Mean +/- SD MAC of sevoflurane was 2.29 +/- 0.14% in llamas and 2.33 +/- 0.09% in alpacas.


CONCLUSIONS
The MAC of sevoflurane in llamas and alpacas was similar to that reported for other species.
Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
Tamara L
TL
Grubb
John W
JW
Schlipf
Thomas W
TW
Riebold
Christopher K
CK
Cebra
Lisa
L
Poland
Xenia
X
Zawadzkas
Nicole
N
Mailhot
D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000592:standards*; D000818:Animals; D002161:Camelids, New World / Q000378:metabolism*; D005260:Female; D007442:Intubation, Intratracheal / Q000662:veterinary; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage / Q000592:standards*; D011446:Prospective Studies; D012119:Respiration / Q000187:drug effects; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane