Descriptive survey of non-commercial randomised controlled trials in the United Kingdom, 1980-2002.
OBJECTIVE
To describe the characteristics of randomised controlled trials supported by the main non-commercial sources of funding in the United Kingdom between 1980 and 2002.


METHODS
Descriptive survey.


METHODS
Randomised controlled trials funded by the Medical Research Council, NHS research and development programme, Department of Health, Chief Scientist Office in Scotland, and medical research charities.


METHODS
1464 randomised controlled trials supported by the main non-commercial sources of funding.


RESULTS
Support for randomised controlled trials by the main sources of non-commercial funding in the United Kingdom has fallen in recent years, without any concomitant increase in the sample sizes of these studies. Drug trials in a limited range of health problems have dominated among the studies supported by the Medical Research Council and medical research charities. Until recently, the NHS research and development programme supported randomised controlled trials of various healthcare interventions, in a wide range of health problems, but between 1999 and 2002 many of the subprogrammes that had commissioned trials were discontinued.


CONCLUSIONS
The future of non-commercial randomised controlled trials in the United Kingdom has been threatened by the discontinuation or demise of national and regional NHS research and development programmes. Support also seems to be declining from the Medical Research Council and the medical research charities. It is unclear what the future holds for randomised controlled trials that address issues of no interest to industry but are of great importance to patients and practitioners.
Chalmers
Iain
I
UK Randomised Controlled Trial Registration Project, UK Cochrane Centre, Oxford OX2 7LG. ichalmers@jameslindlibrary.org
Rounding
Cath
C
Lock
Kate
K
D005381:Financing, Organized; D017150:Public Sector / Q000191:economics; D016032:Randomized Controlled Trials as Topic / Q000191:economics* / Q000706:statistics & numerical data / Q000639:trends; D012109:Research Support as Topic; D006113:United Kingdom