Novel inhibitors of bacterial cell wall synthesis.
Over the past forty years, efforts to discover antibacterials have yielded a wide variety of chemical structures, almost exclusively natural products, which inhibit many steps in cell wall synthesis. Although screening for new cell wall inhibitors has been continuous during that period, there have been few reports of new drugs. With the advent of genomics, high resolution X-ray crystallography and the recognition of the need for new antibiotics to combat resistant organisms, there has been a resurgence in interest in this validated target area.
Silver
Lynn L
LL
Department of Human and Animal Infectious Diseases, Merck & Co., Rahway, NJ 07065, USA. lynn_silver@merck.com
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D002473:Cell Wall / Q000187:drug effects* / Q000201:enzymology; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology; D010457:Peptidoglycan / Q000096:biosynthesis
D000900:Anti-Bacterial Agents; D010457:Peptidoglycan