32P liquid sources--comparison of the effectiveness of postangioplasty versus poststenting intravascular brachytherapy in hypercholesterolemic rabbits. Adjunctly implanted titanium stent does not attenuate the effect of endovascular irradiation.
OBJECTIVE
Endovascular application of ionizing radiation is a promising but still not sufficiently studied means of restenosis prevention. To test the effects of radiation on restenosis, and especially their dependence on whether the angioplasty was followed by stent implantation or not, we performed an in-stent versus no-stent intravascular brachytherapy study in an animal model. Balloon-based, continuous and self-centering, liquid 32P sources seemed the most convenient for the purpose.


METHODS
The radial dose distribution around angioplasty balloons filled with solutions of Na(2)H32PO(4) was calibrated by thermoluminescence dosimetry, both in the absence and presence of stents. The animal experiments were performed on rabbits with induced hypercholesterolemia. The balloons containing 32P were introduced into iliac artery immediately after stent implantation or after angioplasty alone. Radiation effects were evaluated postmortem by comparing thickness of various components of the artery wall.


RESULTS
In the presence of titanium stents (TTS), irradiation with 16 Gy dose at 1.0 mm from the balloon surface was no less effective in reducing hypertrophy in every active layer of the artery wall than without a stent.


CONCLUSIONS
In the animal model, IVBT basing on P(32) liquid sources was no less effective in the stented arteries than in the nonstented ones.
Institute of Oncology, 15 Wybrzeze Armii Krajowej Str., 44-100, Gliwice, Poland. piotrw@io.gliwce.pl
Piotr
P
Walichiewicz
Barbara
B
Petelenz
Krzysztof
K
Wilczek
Wojciech
W
Jacheć
Jerzy
J
Jochem
Andrzej
A
Tomasik
Dariusz
D
Lange
Jan
J
Wodniecki
D000800:Angioplasty, Balloon; D000818:Animals; D001610:Beta Particles / Q000627:therapeutic use; D001918:Brachytherapy / Q000379:methods*; D004195:Disease Models, Animal; D006083:Graft Occlusion, Vascular / Q000517:prevention & control*; D006937:Hypercholesterolemia / Q000532:radiotherapy / Q000601:surgery; D007083:Iliac Artery / Q000528:radiation effects / Q000601:surgery; D010761:Phosphorus Radioisotopes / Q000008:administration & dosage*; D011817:Rabbits; D011897:Random Allocation; D015607:Stents; D014025:Titanium / Q000627:therapeutic use; D016896:Treatment Outcome
D010761:Phosphorus Radioisotopes; D014025:Titanium