Sugar/steroid/sugar conjugates: sensitivity of lipid binding to sugar structure.
[structure: see text]. Three steroids, each bearing a sugar on rings A and D, have been synthesized. Their effect on the "melting" behavior of a lipid bilayer depends on whether the sugar is glucose, galactose, or mannose. Packing constraints dictate how the lipid bilayer responds to the sugars.
Mbadugha
Bessie N A
BN
Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA.
Menger
Fredric M
FM
D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry; D015113:Androstane-3,17-diol / Q000031:analogs & derivatives* / Q000737:chemistry; D002152:Calorimetry, Differential Scanning; D005690:Galactose / Q000031:analogs & derivatives / Q000737:chemistry; D005947:Glucose / Q000031:analogs & derivatives / Q000737:chemistry; D006601:Hexoses / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D008358:Mannose / Q000031:analogs & derivatives / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D044367:Phase Transition; D013256:Steroids / Q000737:chemistry
D006601:Hexoses; D008051:Lipid Bilayers; D008081:Liposomes; D013256:Steroids; D015113:Androstane-3,17-diol; D015060:1,2-Dipalmitoylphosphatidylcholine; D005947:Glucose; D008358:Mannose; D005690:Galactose