Assessment of fetal liver volume and umbilical venous volume flow in pregnancies complicated by insulin-dependent diabetes mellitus.
OBJECTIVE
To determine fetal liver volume and its relation with umbilical venous volume flow and maternal glycosylated haemoglobin (HbA1c) in pregnancies complicated by diabetes mellitus type I.


METHODS
A cross sectional matched control study. Obstetric out patient clinic, Erasmus MC-University Medical Centre, Rotterdam.


METHODS
Data from fetuses of diabetic women (n = 32; 18-36 weeks) were compared with data from normal controls (n = 32) matched for gestational age.


METHODS
Umbilical venous cross sectional area (mm(2)) and time-averaged velocity (mm/s Doppler) were determined for calculation of volume flow (mL/min) and flow per kilogram fetal weight (mL/min/kg). Umbilical artery pulsatility index was determined. Fetal liver volume measurements were obtained using a Voluson 530-D.


METHODS
Fetal liver volume, umbilical venous volume flow and downstream impedance.


RESULTS
A statistically significant difference between fetuses of diabetic women and normal controls was found for liver volume (mean [SD]: 45.9 [34.0] vs 38.3 [28.7] mL), abdominal circumference (22.2 [6.6] vs 21.3 [5.6] cm), estimated fetal weight (1162 [898] vs 1049 [765] g) and fetoplacental weight ratio (0.22 vs 0.19) and liver volume/estimated fetal weight ratio (4.13% [0.007] vs 3.62% [0.009]). Umbilical venous volume flow (mL/min) and umbilical artery pulsatility index were not essentially different between the two study groups, but umbilical venous volume flow per kilogram fetal weight was lower (P < 0.05) in the diabetes group (94.3 [26.1] mL/min kg) compared with normal controls (109.5 [28.0] mL/min/kg). A positive correlation existed between fetal liver volume and maternal HbA1c (P = 0.002).


CONCLUSIONS
Measurement of fetal liver volume by three-dimensional ultrasound may play a role in identifying fetal growth acceleration in diabetic pregnancies. Fetal liver volume increase is positively related to maternal HbA1c levels reflecting degree of maternal glycemic control. Fetal liver volume normalised for estimated fetal weight is significantly higher in the fetuses of diabetic women. In the present study, umbilical venous volume flow and fetoplacental downstream impedance are not different between diabetic and normal pregnancies.
Department of Obstetrics and Gynaecology, Erasmus Medical Centre, Rotterdam, The Netherlands.
Simona M
SM
Boito
Piet C
PC
Struijk
Nicolette T C
NT
Ursem
Theo
T
Stijnen
Juriy W
JW
Wladimiroff
D000328:Adult; D001724:Birth Weight; D001783:Blood Flow Velocity / Q000502:physiology; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D005260:Female; D005333:Fetus / Q000098:blood supply*; D005865:Gestational Age; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000196:embryology*; D009929:Organ Size; D010920:Placenta; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D012039:Regional Blood Flow; D014471:Umbilical Veins / Q000502:physiology*