The effect of fluconazole treatment on tumor necrosis factor-alpha production in murine candidiasis.
That systemic candidiasis increases TNF-alpha has been proved in various studies. In our study, we investigated if fluconazole too, which is used in treatment, has an additional effect on the increase of TNF-alpha. On the sixth day of the experimental infection, it was measured that TNF-alpha levels of candidiasis was 699 +/- 60 pg/ml whereas it was 683 +/- 35 pg/ml in the mice that were treated with fluconazole. TNF-alpha levels were measured by enzyme-linked immunosorbant assay. Due to the fact that no statistically significant difference was found between them (p > .05) it was thought that fluconazole did not have an additional effect on the increase of TNF-alpha in candidiasis.
Department of Microbiology and Clinical Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey. aysekalkanci@email.com
Ayse
A
Kalkanci
Semra
S
Kustimur
D000818:Animals; D000935:Antifungal Agents / Q000378:metabolism / Q000627:therapeutic use*; D002177:Candidiasis / Q000097:blood / Q000188:drug therapy*; D005260:Female; D015725:Fluconazole / Q000378:metabolism / Q000627:therapeutic use*; D007668:Kidney / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D000935:Antifungal Agents; D014409:Tumor Necrosis Factor-alpha; D015725:Fluconazole