Asymmetrical modulation of interleukin-10 release in patients with intracerebral hemorrhage.
The brain modulates the immune system in an asymmetrical way. Intracerebral hemorrhage triggers IL-6 and IL-10 release into blood. We measured (using ELISA method) serum IL-6 and IL-10 in acute phase of intracerebral hemorrhage in 11 patients with right hemisphere's hematoma and 15 patients with left hemisphere's hematoma. These patients did not differ significantly with respect to their age, size, and location of hematoma. IL-6 level was comparable in patients with left hematoma and patients with right hematoma, but patients with left hematoma had significantly higher level of IL-10 than patients with right hematoma. These results suggest that left and right hemisphere could modulate IL-10 release in different way.
Dziedzic
Tomasz
T
Department of Neurology, Collegium Medicum, Jagiellonian University, 31-503 Kraków, ul. Botaniczna 3, Poland. dziedzictom@mediclub.pl
Slowik
Agnieszka
A
Klimkowicz
Aleksandra
A
Szczudlik
Andrzej
A
D000368:Aged; D002543:Cerebral Hemorrhage / Q000097:blood*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006406:Hematoma / Q000097:blood; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D015213:Neuroimmunomodulation / Q000502:physiology
D015850:Interleukin-6; D016753:Interleukin-10