[Multivariate analysis of recurrence in T1 bladder transitional cell carcinoma].
OBJECTIVE
To investigate the prognostic value of some clinicopathologic indexes and biologic tumor markers in predicting recurrence in T1 transitional cell carcinoma (TCC) of the bladder.


METHODS
The expressions of p53, E-cadherin and VEGF of 75 patients with T1 primary bladder TCC were detected by streptabitin peroxidase (SP) immunohistochemical methods. The effects of clinicopathologic indexes and biologic tumor markers on recurrence were assessed by Kaplan-Meier and Cox proportional hazards model.


RESULTS
The 1-, 3-, and 5-year recurrence- free survival rates were 68.0%, 45.3% and 20.9%. In Kaplan-Meier analysis, tumor mutifocality and the expression of p53, E-cadherin and VEGF were associated with recurrence. In multivariate analysis, the independent recurrence variables were tumor mutifocality, the expression of p53 and E-cadherin.


CONCLUSIONS
Tumor mutifocality and the abnormal expression of p53 and E-cadherin are the variables that independently predict recurrence in T1 transitional cell carcinoma of the bladder.
First Hospital, Institute of Urology of Peking University, Beijing 100034, China.
Jun
J
Zhang
Li
L
Zeng
Gui-zhong
GZ
Li
Xin-yu
XY
Yang
Tong-li
TL
Xia
Yan-qun
YQ
Na
Ying-lu
YL
Guo
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000032:analysis; D002295:Carcinoma, Transitional Cell / Q000209:etiology* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000209:etiology* / Q000401:mortality; D009367:Neoplasm Staging; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D001749:Urinary Bladder Neoplasms / Q000209:etiology* / Q000401:mortality; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
D015820:Cadherins; D016159:Tumor Suppressor Protein p53; D042461:Vascular Endothelial Growth Factor A