[A case of renal cell carcinoma with lymph node metastasis keeping remission for five years by adjuvant immunotherapy with ubenimex].
We report herein the long-term remission of a woman following postoperative ubenimex therapy. A 46-year-old woman with a tumor in the left kidney and a swollen para-aortic lymph node was referred to our department for surgery. Preoperative computed tomography revealed a stage IV renal cell carcinoma. Since her right kidney naturally ruptured after hospitalization, the patient underwent bilateral kidney and partial paraaortic lymph node dissection. Histopathological tests revealed that the tumor was T3, N2, M0, mixed type. As the residual lymph node was swollen at 4 months after the operation, treatment with ubenimex was started. Five years after the operation, no new lymph node metastases were recognized under continuous treatment with ubenimex. Single administration of ubenimex appears to be effective for cases of renal cell carcinoma with lymph node metastasis to maintain good patient QOL because of its few side effects.
Sugano
Osamu
O
Dept. of Urology, Yamagata Prefectural Central Hospital.
Muto
Akinori
A
Kato
Masanori
M
Ono
Kunio
K
D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000556:secondary*; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007167:Immunotherapy; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D007930:Leucine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009392:Nephrectomy; D012074:Remission Induction
D000903:Antibiotics, Antineoplastic; D007930:Leucine; C012211:ubenimex