A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest.
Bioassay-guided fractionation of the EtOAc extract of the twigs of Garcinia macrophylla from Suriname produced the known benzophenone, guttiferone A (1), and a new guttiferone analogue, guttiferone G (2). Friedelin was also isolated. The structures of compounds 1 and 2 were elucidated using 1D and 2D NMR spectroscopy. Compounds 1 and 2 were weakly cytotoxic in the A2780 human ovarian cell line, with IC (50) values of 6.8 and 8.0 microg/mL, respectively.
Department of Chemistry M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Russell B
RB
Williams
Jeannine
J
Hoch
Thomas E
TE
Glass
Randy
R
Evans
James S
JS
Miller
Jan H
JH
Wisse
David G
DG
Kingston
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001577:Benzophenones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D029760:Garcinia; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D010051:Ovarian Neoplasms / Q000517:prevention & control; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013532:Suriname
D000972:Antineoplastic Agents, Phytogenic; D001577:Benzophenones; D010936:Plant Extracts