New trimethylaluminum-induced mannich-type reaction of hydrazones.
Trimethylaluminum addition to N-monoalkyl or N-monoaryl hydrazones followed by aldehyde addition leads to the formation of N-alkylated hydrazones in a new formal Mannich-type process. Addition compounds were also obtained in moderate yields with ketones. The mechanism as well as possible intermediates involved in the reaction are discussed.
Laboratoire Chimie et procédés, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75739 Paris 15, France. elkaim@ensta.fr
Laurent
L
El Kaim
Laurence
L
Grimaud
Yannick
Y
Perroux
Cornelia
C
Tirla