A whole genome screen for association with multiple sclerosis in Portuguese patients.
Multiple sclerosis (MS) is common in Europe affecting up to 1:500 people. In an effort to identify genes influencing susceptibility to the disease, we have performed a population-based whole genome screen for association. In this study, 6000 microsatellite markers were typed in separately pooled DNA samples from MS patients (n=188) and matched controls (n=188). Interpretable data was obtained from 4661 of these markers. Refining analysis of the most promising markers identified 10 showing potential evidence for association.
UnIGENe-IBMC, University of Porto, Portugal.
M
M
Santos
J
J
Pinto-Basto
M E
ME
Rio
M J
MJ
Sá
A
A
Valença
A
A
Sá
J
J
Dinis
J
J
Figueiredo
L
L
Bigotte de Almeida
I
I
Coelho
S
S
Sawcer
E
E
Setakis
A
A
Compston
J
J
Sequeiros
P
P
Maciel
D000293:Adolescent; D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods* / Q000706:statistics & numerical data; D015894:Genome, Human; D006801:Humans; D007391:International Cooperation; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D011174:Portugal / Q000453:epidemiology