A whole genome association study in multiple sclerosis patients from north Portugal.
Genetic factors are known to influence susceptibility to multiple sclerosis (MS) but the genes involved are largely undefined. Here, we report an association study based on 200 patients and 200 controls from the Porto region in Portugal. A total of 3974 markers were successfully typed from which we have identified 46 markers showing evidence of association. When compared to a physical map three regions were found with two of these markers less than 1.5 Mb apart: chromosomes 6p21.3 (the MHC region), 6q14.1 and 7q34.
Pathology and Molecular Immunology Department, Instituto Ciências Biomédicas Abel Salazar, University of Porto, Porto, Portugal. bertams@icbas.up.pt
Berta
B
Martins Silva
Theodora
T
Thorlacius
Kjartan
K
Benediktsson
Clara
C
Pereira
Ragnheidur
R
Fossdal
Hjortur H
HH
Jonsson
Ana
A
Silva
Isabel
I
Leite
J
J
Cerqueira
Paulo P
PP
Costa
Monica
M
Marta
Thomas
T
Foltynie
Stephen
S
Sawcer
Alastair
A
Compston
Aslaug
A
Jonasdottir
D000293:Adolescent; D000368:Aged; D016022:Case-Control Studies; D004247:DNA / Q000097:blood; D019075:Electrophoresis, Capillary; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods* / Q000706:statistics & numerical data; D005828:Genetics, Population; D015894:Genome, Human; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011174:Portugal / Q000453:epidemiology
D004247:DNA