Role of macrophage inflammatory protein-1alpha in T-cell-mediated immunity to viral infection.
The immune response to lymphocytic choriomeningitis virus in mice lacking macrophage inflammatory protein-1alpha (MIP-1alpha) was evaluated. Generation of virus-specific effector T cells is unimpaired in MIP-1alpha-deficient mice. Furthermore, MIP-1alpha is not required for T-cell-mediated virus control or virus-induced T-cell-dependent inflammation. Thus, MIP-1alpha is not mandatory for T-cell-mediated antiviral immunity.
Institute of Medical Microbiology and Immunology, University of Copenhagen, Copenhagen, Denmark.
Andreas N
AN
Madsen
Anneline
A
Nansen
Jan P
JP
Christensen
Allan R
AR
Thomsen
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002465:Cell Movement; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D006968:Hypersensitivity, Delayed / Q000209:etiology; D008216:Lymphocytic Choriomeningitis / Q000276:immunology*; D019402:Macrophage Inflammatory Proteins / Q000502:physiology*; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D000956:Antigens, Viral; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D019402:Macrophage Inflammatory Proteins