[Central nervous system involvement by histoplasmosis as the unique manifestation of this disease in immunocompetent patients: presentation of two cases].
We present two patients with central nervous system involvement as the unique clinical manifestation of histoplasmosis. A clinical review confirmed the infrequency of this form of the disease, overall in childhood, being one of these cases the youngest in Brazilian reports. Comments about the diversity of clinical presentation and main differential diagnosis are presented. We analyze the serologic and cerebrospinal fluid results and, finally, discuss the drugs and duration of treatment.
Serviço de Moléstias Infecciosas, Hospital do Servidor Público Estadual 'Francisco Morato de Oliveira', São Paulo, SP, Brasil. gclevi@uol.com.br
Guido C
GC
Levi
Cristina M
CM
Pozzi
Sônia M D S
SM
Hirschheimer
Wiliam H
WH
Chahade
Hélio R
HR
Gomes
Celso
C
Granato
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D020314:Central Nervous System Fungal Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000382:microbiology*; D002648:Child; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006660:Histoplasmosis / Q000134:cerebrospinal fluid / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male
D000935:Antifungal Agents; D015725:Fluconazole