Folic acid-conjugated nanostructured materials designed for cancer cell targeting.
Shell cross-linked nanoparticles (SCKs) constitute a unique class of materials with amphiphilic core-shell morphology; SCKs are characterised by their structural integrity and available functionality to attach receptor-recognising or receptor-specific ligands on the shell surface and, therefore, hold great potential in drug delivery applications; in an attempt to develop novel, cancer cell specific delivery vehicles, folate receptor targeted SCKs have been prepared.
Department of Chemistry, Washington University, One Brookings Drive, CB 1134, Saint Louis, Missouri 63130, USA.
Dipanjan
D
Pan
Jeffrey L
JL
Turner
Karen L
KL
Wooley
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics; D002352:Carrier Proteins / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D015195:Drug Design; D058973:Folate Receptors, GPI-Anchored; D005492:Folic Acid / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D036103:Nanotechnology; D011092:Polyethylene Glycols / Q000737:chemistry / Q000493:pharmacokinetics; D011956:Receptors, Cell Surface / Q000378:metabolism*
D000970:Antineoplastic Agents; D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D008024:Ligands; D011956:Receptors, Cell Surface; D011092:Polyethylene Glycols; D005492:Folic Acid