Secretion of the orgC gene product by Salmonella enterica serovar Typhimurium.
HilA activates the transcription of genes on Salmonella pathogenicity island 1 (SPI1), which encodes a type III secretion system (TTSS). Previous studies showed that transposon insertions in orgC, a gene located on SPI1, increase hilA expression. We characterize the orgC gene product and show that it is secreted via the SPI1 TTSS. We propose a model whereby OrgC functions as a secreted repressor of the SPI1 virulence genes.
Day
James B
JB
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. james.day@cfsan.fda.gov
Lee
Catherine A
CA
D001426:Bacterial Proteins / Q000235:genetics* / Q000502:physiology*; D002460:Cell Line; D006801:Humans; D012486:Salmonella typhimurium / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D015534:Trans-Activators / Q000235:genetics; D014774:Virulence
D001426:Bacterial Proteins; C102236:HilA protein, Salmonella; C419942:Spi1 protein, Salmonella; D015534:Trans-Activators