[European multicenter cross-sectional study on exposure to low doses of benzene].
A cross-sectional multicenter european study has been carried out to evacuate the relations between exposure to low level of benzene and biological markers of internal dose (t,t-MA, S-PMA) and early biological effect (DNA-SSB). The research has shown significantly increased levels (adjusted for smoking habits) of the urinary excretion of t,t-MA, S-PMA and DNA-SSB in petrochemical workers (mean benzene level = 5,694 micrograms/m3) but not in filling station attendants, traffic police officers, and bus drivers compared to referent workers. Dose-response relations were detected between benzene air levels, t,t-MA, S-PMA and DNA-SSB in petrochemical workers, with significantly increased levels of DNA-SSB detected for benzene exposure levels in the range 391-1,800 micrograms/m3 (0.12-0.58 ppm).
Merlo
F
F
Istituto Nazionale per la Ricerca sul Cancro, Genova.
Bertazzi
P A
PA
Bolognesi
C
C
Colombi
A
A
Fustinoni
S
S
Buratti
M
M
Farmer
P
P
Garte
S
S
Levy
L
L
Pesatori
A C
AC
Popov
T
T
Taioli
E
E
Valerio
F
F
Consonni
D
D
D001554:Benzene / Q000009:adverse effects* / Q000378:metabolism; D005060:Europe; D006801:Humans; D016273:Occupational Exposure / Q000706:statistics & numerical data*
D001554:Benzene