A whole genome screen for association in Polish multiple sclerosis patients.
We have performed the first systematic search for MS susceptibility genes completed in the Polish population. This screen was performed using 6000 microsatellite markers typed in pooled DNA from cases (n=200), controls (n=200) and trio families (n=129). Five associated markers are identified, one (D6S2444) from the HLA region and four are from novel regions not previously associated with MS, 2p16 (D2S2153), 3p13 (D3S3568), 7p22 (D7S2521) and 15q26 (D15S649).
Bielecki
Bartosz
B
Department of Neurology, Medical University of Lodz, 22 Kopcinskiego Street, 90-153 Lodz, Poland.
Mycko
Marcin P
MP
Tronczyńska
Ewa
E
Bieniek
Marek
M
Sawcer
Stephen
S
Setakis
Efrosini
E
Benediktsson
Kjartan
K
Compston
Alastair
A
Selmaj
Krzysztof W
KW
D000328:Adult; D016022:Case-Control Studies; D004247:DNA / Q000097:blood; D019075:Electrophoresis, Capillary; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods* / Q000706:statistics & numerical data; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D011044:Poland / Q000453:epidemiology; D016133:Polymerase Chain Reaction / Q000706:statistics & numerical data
D004247:DNA