Associations between prostate cancer susceptibility and parameters of exposure to ultraviolet radiation.
Low sunlight exposure confers increased prostate cancer risk. In a study conducted in northern England, we investigated how combinations of exposure measures affect this risk. Recursive partitioning was used to identify combinations of exposure parameters that distinguished 453 prostate cancers from 312 benign hypertrophy patients. Sunbathing score most significantly defined cancer patients; 78.7% men with low scores (</=3.0) and 40.2% men with high scores (>8.0) had cancer. These subgroups were stratified by childhood sunburning, holidays in a hot climate and skin type such that subgroups with a 13.0-fold increased risk of cancer were identified.
Department of Urology, North Staffordshire Hospital, Staffordshire, UK.
Dhaval
D
Bodiwala
Christopher J
CJ
Luscombe
Michael E
ME
French
Samson
S
Liu
Mark F
MF
Saxby
Peter W
PW
Jones
Anthony A
AA
Fryer
Richard C
RC
Strange
D000230:Adenocarcinoma / Q000209:etiology*; D000367:Age Factors; D004198:Disease Susceptibility; D005127:Eye Color; D006200:Hair Color; D006370:Heliotherapy; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D010641:Phenotype; D011470:Prostatic Hyperplasia / Q000209:etiology*; D011471:Prostatic Neoplasms / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D012867:Skin / Q000033:anatomy & histology; D013471:Sunburn / Q000150:complications*; D013472:Sunlight; D014466:Ultraviolet Rays / Q000009:adverse effects*