Ultrasound agents may open the blood-brain barrier in rats and aggravate pathologic consequences of experimental head trauma.
Unilateral intracarotid injection of contrast agents may considerably destabilize the blood-brain barrier in rats. This leads to vasogenic edema in the ipsilateral hemisphere. Mortality and extravasation increased significantly when administration of these ultrasound contrast agents was followed by mild traumatic brain injury. Direct administration to the cerebral circulation is, therefore, indicative for edema-related pathology and may amplify the consequences of experimental neurotrauma.
University Hospital Antwerp, Department of Neurosurgery, Edegem, Antwerp, Belgium. servanrooker@belgacom.net
Servan
S
Rooker
Jos
J
Van Reempts
Bruno
B
Van Deuren
Marcel
M
Borgers
Philippe G
PG
Jorens
Bernard P
BP
Paelinck
Jan
J
Verlooy
D000418:Albumins / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001929:Brain Edema / Q000209:etiology / Q000473:pathology; D001930:Brain Injuries / Q000473:pathology*; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000473:pathology*; D005466:Fluorocarbons / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D007839:Functional Laterality; D007269:Injections, Intra-Arterial; D008297:Male; D009410:Nerve Degeneration / Q000209:etiology* / Q000473:pathology; D011134:Polysaccharides / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D051381:Rats; D014463:Ultrasonography
D000418:Albumins; D003287:Contrast Media; C099458:FS 069; D005466:Fluorocarbons; D011134:Polysaccharides; C059891:SHU 508