Microtubule-associated protein 1B function during normal development, regeneration, and pathological conditions in the nervous system.
Microtubule-associated protein 1B is the first MAP to be expressed during the development of the nervous system. Several different approaches have revealed that MAP1B function is associated with microtubule and actin microfilament polymerization and dynamics. In recent years, the generation of molecular models to inactivate MAP1B function in invertebrates and mammals has sparked some controversy about the real role of MAP1B. Despite discrepancies between some studies, it is clear that MAP1B plays a principal role in the development of the nervous system. In this article, we summarize the evidence for MAP1B function in a wide variety of cellular processes implicated in the proper construction of the nervous system. We also discuss the role of MAP1B in pathological processes.
Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Cantoblanco 28049, Madrid, Spain.
Christian
C
Gonzalez-Billault
Eva Maria
EM
Jimenez-Mateos
Alfredo
A
Caceres
Javier
J
Diaz-Nido
Francisco
F
Wandosell
Jesus
J
Avila
D000818:Animals; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D009420:Nervous System / Q000254:growth & development* / Q000503:physiopathology*; D009422:Nervous System Diseases / Q000503:physiopathology*; D009424:Nervous System Physiological Phenomena
D008869:Microtubule-Associated Proteins; C085284:microtubule-associated protein 1B