A novel sunscreen agent having antimelanoma activity.
A novel series of eight dibenzoylmethane derivatives having both sunscreen and cytotoxic activity has been obtained by derivatizing commercial dibenzoyl methanes. Four human cancer cell lines (MCF 7 (breast), NCI ADR (breast expressing the multidrug resistance phenotype), NCI 460 (lung) and UACC 62 (melanoma)) were used for the cytotoxic assay. Eight among the 19 dibenzoylmethane derivatives showed cytotoxicity against these four cell lines. Absorption spectroscopies revealed that these compounds can be used as sunscreens against UV radiation.
Instituto de Química, Universidade Estadual de Campinas, CP 6154, SP, 13083-970 Campinas, Brazil.
Marisa A
MA
Nogueira
Eva G
EG
Magalhães
Aderbal F
AF
Magalhães
Débora N
DN
Biloti
Antonio
A
Laverde
Francisco B T
FB
Pessine
João E
JE
Carvalho
Luciana K
LK
Kohn
Márcia A
MA
Antônio
Anita J
AJ
Marsaioli
D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D001565:Benzoates / Q000737:chemistry / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D047188:Chalcones; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000517:prevention & control; D012878:Skin Neoplasms / Q000517:prevention & control; D013473:Sunscreening Agents / Q000737:chemistry / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D001565:Benzoates; D047188:Chalcones; D013473:Sunscreening Agents; C061481:dibenzoylmethane