Uterine artery Doppler blood flow in cases of hydatidiform mole and its correlation with beta-hCG.
OBJECTIVE
To study the correlation between Doppler blood flow and beta-human chorionic gonadotropin (hCG), to assess the course of the disease and the follow up evaluation.


METHODS
This study was conducted in Assiut University Hospital, Department of Obstetrics and Gynecology.


METHODS
Longitudinal study.


METHODS
Fifteen cases of vesicular mole were recruited and followed up. The patients were evaluated the day before evacuation of the uterus. This included clinical assessment, Doppler uterine artery blood flow velocity waveforms using the Doppler indices and assessment of the serum level of beta-hCG. These cases were followed up every 2 weeks in the first 2 months, and every month thereafter until the 6 month.


RESULTS
Twelve patients showed continuous decrease in beta-hCG level from 1192+/-697 to 6+/-11 IU/ml by the end of the second month. Systolic-diastolic (S/D) increased from (2.57+/-1.13) to (15.9+/-2.07) (P<0.0001), RI increased from 0.55+/-0.15 to 1.0+/-0.26(P<0.0001) and PI increased from 1.02+/-0.47 to 6.12+/-2.34 (P<0.0001). One patient showed a fluctuating level of beta-hCG around the same level, and two showed a slowed decrease. Doppler indices showed similar results. There is a strong correlation between beta-hCG and all Doppler indices throughout the course of follow up: beta-hCG and S/D r<0.01, beta-hCG and RI r<0.01 and beta-hCG and PI r<0.01.


CONCLUSIONS
Doppler ultrasound can be used as an adjuvant tool in the follow up of cases of vesicular mole and can predict the progress in the course of the disease.
Department of Obstetrics and Gynecology, Faculty of Medicine, Assiut University, 30-060 Assiut, Egypt. abdelaald@yahoo.com
Diaa Eldeen M
DE
Abd El Aal
Elwany D
ED
El Senosy
Momen A
MA
Kamel
Maha
M
Atwa
D001158:Arteries; D001783:Blood Flow Velocity; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000503:physiopathology*; D011247:Pregnancy; D011673:Pulsatile Flow; D018608:Ultrasonography, Doppler; D014594:Uterine Neoplasms / Q000503:physiopathology*; D014599:Uterus / Q000098:blood supply*; D014655:Vascular Resistance
D018997:Chorionic Gonadotropin, beta Subunit, Human