Palladium(II) acetate mediated oxidative cyclization of omega-unsaturated alpha-cyano ketones. A facile methylenecyclopentane annulation process.
A highly efficient methylenecyclopentane annulation process has been developed based on the Pd(II)-mediated oxidative cyclization of omega-unsaturated alpha-cyano ketones, readily accessed via the Michael addition of 3-butenylmagnesium bromide with 2-cyano-2-cycloalkenones.
Kung
Liang-Rern
LR
Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan 30013, Republic of China.
Tu
Che-Hao
CH
Shia
Kak-Shan
KS
Liu
Hsing-Jang
HJ