[Significance of the system of atrial natriuretic peptides in heart failure and hypertension].
This literature review presents current information on mechanisms of realization and action of natriuretic peptides in heart failure and hypertension. Significant role in degradation of natriuretic peptides belongs to neutral endopeptidase. Basing on theoretical and experimental data novel class of drugs - inhibitors of neutral endopeptidase - has been developed. The paper contains discussion of first results of the use of drugs from this class for the treatment of chronic heart failure.
Gurevich
M A
MA
M.F. Vladimirsky Moscow Region Research Clinical Institute, ul. Schepkina 61/2, 129110 Moscow, Russia.
Mravian
S R
SR
Veselova
T E
TE
D009320:Atrial Natriuretic Factor / Q000378:metabolism / Q000627:therapeutic use*; D002908:Chronic Disease; D006333:Heart Failure / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism; D015260:Neprilysin / Q000187:drug effects / Q000378:metabolism
D009320:Atrial Natriuretic Factor; D015260:Neprilysin