Comparative, double-blind, randomized, placebo-controlled trial of intraperitoneal of bupivacaine and lidocaine for pain control after diagnostic laparoscopy.
OBJECTIVE
To compare the effect of intraperitoneal bupivacaine and lidocaine on reducing pain after diagnostic laparoscopy.


METHODS
Randomized, double-blind, placebo-controlled study (Canadian Task Force classification I).


METHODS
University teaching hospital.


METHODS
One hundred thirty-four women with unexplained infertility.


METHODS
Diagnostic laparoscopy with intraperitoneal administration of bupivacaine or lidocaine.


RESULTS
Patients were randomized into one of four groups. In group A, at the end of laparoscopy 0.125% bupivacaine 30 ml was instilled into the pelvic cavity and the same dose was instilled over the diaphragmatic vault. Groups B and C received the same volume of 5% lidocaine and normal saline, respectively. Group D received no intraperitoneal agent. The verbal pain scale questionnaire was used to assess postoperative pain. Pain scores 2 and 24 hours postoperatively were significantly lower for group A than for groups B and C (p = 0.0001). Scores in group B were also significantly lower than those in groups C and D (p = 0.0001). Women in group A required less additional analgesia than those in the other groups.


CONCLUSIONS
Compared with lidocaine and placebo, intraperitoneal bupivacaine significantly decreased postoperative pain, and this effect was long lasting.
Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Mohammad Ebrahim
ME
Parsanezhad
Masoud
M
Lahsaee
Saeed
S
Alborzi
Homayra
H
Vafaei
Ernst Heinrich
EH
Schmidt
D000328:Adult; D000779:Anesthetics, Local; D002045:Bupivacaine / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis; D007322:Instillation, Drug; D010535:Laparoscopy; D008012:Lidocaine / Q000008:administration & dosage*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D010529:Peritoneal Cavity; D011446:Prospective Studies; D013997:Time Factors
D000779:Anesthetics, Local; D008012:Lidocaine; D002045:Bupivacaine