[Mechanism of action of a novel antitumor preparation of chlofiden. Effect on RNA synthesis].
Study of the influence of the antitumor preparation chlofiden on RNA synthesis by sarcoma 45 and liver cells was carried out using 14C-orotic acid. Chlofiden was shown to activate RNA transport from the nucleus to the cytoplasm, and to reduce label incorporation into the nuclear and cytoplasmic RNA. Chlofiden increased the rate of RNA processes, which promoted some increase of label incorporation into low molecular RNA fraction of the nucleus and the cytoplasm. High and stable antitumor activity of chlofiden on sarcoma 45 was established.
Institute of Pharmacology and Toxicology, Academy of Medical Sciences of Ukraine, Kyiv.
N I
NI
Sharykina
I G
IG
Kudriavtseva
G P
GP
Pavlovskaia
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001693:Biological Transport, Active / Q000187:drug effects; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D005021:Ethylamines / Q000494:pharmacology* / Q000627:therapeutic use; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D007279:Injections, Subcutaneous; D007700:Kinetics; D008297:Male; D009963:Orotic Acid / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis*; D051381:Rats; D012509:Sarcoma / Q000188:drug therapy* / Q000378:metabolism; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; C480822:Chlofiden; D005021:Ethylamines; D009963:Orotic Acid; D012313:RNA