Decreased L5 spinal nerve ligation nociceptive behavior following L4 spinal nerve transection.
This study used the escape/avoidance paradigm to explore the role of the L4 spinal nerve in L5 ligation nociception. Unlike L5-ligated controls, L5-ligated/L4-transected animals had normal mechanical withdrawal threshold and did not escape/avoid mechanical stimulation of the afflicted paw. The result from the escape/avoidance paradigm, which does not rely on a reflexive withdrawal response, directly supports the hypothesis that the L4 spinal nerve contributes to L5 ligation neuropathic pain.
LaGraize
Stacey C
SC
Department of Psychology, University of Texas at Arlington, Box 19528, Arlington, TX 76019, USA.
Borzan
Jasenka
J
Fuchs
Perry N
PN
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D008026:Ligation; D008297:Male; D010146:Pain / Q000523:psychology*; D017288:Pain Threshold / Q000502:physiology; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013127:Spinal Nerves / Q000502:physiology*