[Enzymes of snake venoms].
Snakes' venom is a mixture of biologically active substances, containing proteins and peptides. A number of these proteins interact with haemostasis system components. Activators and inhibitors affecting blood coagulation and fibrinolysis systems are of special interest. Venom components can be classified into three main groups, such as procoagulants, anticoagulants and fibrinolytic enzymes according to their action. This review is focused on enzymes from Agkistrodon halys halys venom. They are thrombine-like enzyme, named Ancystron-H, flbrinogenolytic enzyme, protein C activator and platelet aggregation inhibitor. Ancystron-H is used for determination of fibrinogen level in blood plasma of patients undergoing heparin treatment and blood coagulation inhibitors accumulation. The fibrinogenolytic enzyme can be used as the instrument for protein-protein interactions in fibrinogen-fibrin system. The protein C activator is used for protein C level determination in blood plasma with different pathologies. Functions of the platelet aggregation inhibitor, belonging to disintegrins group, can be used for development of antithrombotic preparations. Information about the use of snake venoms in science and medicine is presented.
Gornitskaia
O V
OV
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv. gornitskaya@mail.ru
Platonova
T N
TN
Volkov
G L
GL
D000721:Ancrod / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D012103:Batroxobin / Q000302:isolation & purification / Q000494:pharmacology; D004798:Enzymes / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D011486:Protein C / Q000032:analysis; D012697:Serine Endopeptidases / Q000302:isolation & purification / Q000494:pharmacology; D012910:Snake Venoms / Q000201:enzymology*; D012911:Snakes / Q000502:physiology*
D004798:Enzymes; D011486:Protein C; D012910:Snake Venoms; D000721:Ancrod; D012103:Batroxobin; D012697:Serine Endopeptidases; C063190:ancistron N