Synthesis and biological activity of sulfur-containing aryl-aldehyde Schiff bases.
A series of chemically modified aryl-aldehyde Schiff bases has been synthesized and tested for their antioxidant activity and radiation protection. We observed that disulfide-containing aryl-aldehyde Schiff base 6c exhibited potent free radical scavenging, antioxidation, and radioprotection activities.
Jiang
Jyh-Jia
JJ
School of Pharmacy, National Defense Medical Center, Taipei, Taiwan.
Chang
Tsu-Chung
TC
Hsu
Wen-Lin
WL
Hwang
Jing-Min
JM
Hsu
Ling-Yih
LY
D000447:Aldehydes / Q000138:chemical synthesis* / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001713:Biphenyl Compounds; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007202:Indicators and Reagents; D015227:Lipid Peroxidation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D010851:Picrates / Q000737:chemistry; D011837:Radiation-Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology*; D013455:Sulfur / Q000737:chemistry*
D000447:Aldehydes; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D010851:Picrates; D011837:Radiation-Protective Agents; D012545:Schiff Bases; D013455:Sulfur; C004931:1,1-diphenyl-2-picrylhydrazyl