[Study on serum p53 protein in cops in Guangzhou city].
OBJECTIVE
Serum p53 protein overexpression was detected in population exposed to traffic exhaust gas to study the relation between traffic exhaust gas and the increased risk in p53 gene mutation.


METHODS
Serum p53 protein expression was measured by enzyme-linked immunosorbent assay. Relationship between different types of job and serum p53 protein overexpression were studied by pearson Chi-square tests.


RESULTS
Results on serum p53 protein overexpression on jobs outside of office (5.74%) were not significantly higher than jobs inside the office. However, it suggested that traffic police men (12.12%) working outside of office, with whose length of service longer than 30 years had a significant overexpression of serum p53 protein than the others (5.36%) whose length of service was less than 30 years (P < 0.05, OR = 2.43, 95% CI: 1.11 - 5.33). Overexpression rate of p53 protein appeared to be 6.89% in the group whose average weekly exposure hours were more than 40 hours, which was significant higher than the group whose exposed hours were less than 40 hours (P < 0.05, OR = 1.71, 95% CI: 1.03 - 2.81).


CONCLUSIONS
The result suggested that traffic exhaust gas was likely to cause mutation of p53 gene and increasing the incidence of lung cancer.
Zhu
Wen-Chang
WC
Department of Epidemiology, The First Military Medical University, Guangzhou 510515, China. zhuwenchang@263.net
Chen
Qing
Q
Chu
Xin-Wei
XW
Luo
Chen-Ling
CL
Wu
Min
M
Wang
Ya-Xian
YX
Chen
Si-Dong
SD
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016158:Genes, p53; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016273:Occupational Exposure; D016159:Tumor Suppressor Protein p53 / Q000097:blood*; D001335:Vehicle Emissions / Q000009:adverse effects*
D016159:Tumor Suppressor Protein p53; D001335:Vehicle Emissions