Nosocomial Mycobacterium bovis-bacille Calmette-Guérin infections due to contamination of chemotherapeutics: case finding and route of transmission.
We studied nosocomial infections due to Mycobacterium bovis bacille Calmette-Guérin (BCG) Onco-TICE bacteria, transmitted by contamination of medication prepared in BCG Onco-TICE-contaminated hoods in the pharmacy, in 5 immunocompromised patients at 3 hospitals. The BCG strains cultured from the patients had the same DNA profile as the BCG Onco-TICE strain used for bladder instillation. To prevent these infections, a change from open to closed preparation was made; strictly separated preparation in time of BCG Onco-TICE instillation and chemotherapy was enforced, the biological safety cabinet was disinfected between preparations, and gloves were changed between preparations.
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands. m.vos@erasmusmc.nl.
Margreet C
MC
Vos
Petra E W
PE
de Haas
Henri A
HA
Verbrugh
Nicole H M
NH
Renders
Nico G
NG
Hartwig
Peter
P
de Man
Arend H J
AH
Kolk
Henk
H
van Deutekom
J L
JL
Yntema
Arnold G
AG
Vulto
Marja
M
Messemaker
Dick
D
van Soolingen
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001500:BCG Vaccine / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D003428:Cross Infection / Q000276:immunology / Q000382:microbiology*; D004340:Drug Contamination; D005260:Female; D006801:Humans; D016867:Immunocompromised Host / Q000187:drug effects / Q000276:immunology; D008297:Male; D009164:Mycobacterium Infections / Q000276:immunology / Q000382:microbiology*; D009163:Mycobacterium bovis / Q000254:growth & development*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D001500:BCG Vaccine