Prothrombin gene variants in non-Caucasians with fetal loss and intrauterine growth retardation.
Thrombotic predisposition may affect pregnancy outcome, but in non-Caucasians the contributing genetic factors are poorly characterized. Two recently identified prothrombin gene mutations (20209C>T and 20221C>T) have been observed in non-Caucasian patients with thrombosis. The mutations are located near the commonly identified variant 20210G>A and have not been reported in Caucasian patients. The authors report a novel connection with pregnancy complications. The identification of sequence variants other than 20210G>A in the 3'-untranslated region of the prothrombin gene suggests that additional nucleotide substitutions may contribute to the development of thrombotic events and adverse pregnancy outcomes, especially in less well-characterized populations.
Schrijver
Iris
I
Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA. iris.schijver@medcenter.stanford.edu
Lenzi
Tiffanee J
TJ
Jones
Carol D
CD
Lay
Marla J
MJ
Druzin
Maurice L
ML
Zehnder
James L
JL
D000022:Abortion, Spontaneous / Q000235:genetics*; D000328:Adult; D001741:Black or African American / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D005260:Female; D005317:Fetal Growth Retardation / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D011516:Prothrombin / Q000235:genetics* / Q000378:metabolism
D011516:Prothrombin