A whole genome screen for association in Polish multiple sclerosis patients.
We have performed the first systematic search for MS susceptibility genes completed in the Polish population. This screen was performed using 6000 microsatellite markers typed in pooled DNA from cases (n=200), controls (n=200) and trio families (n=129). Five associated markers are identified, one (D6S2444) from the HLA region and four are from novel regions not previously associated with MS, 2p16 (D2S2153), 3p13 (D3S3568), 7p22 (D7S2521) and 15q26 (D15S649).
Department of Neurology, Medical University of Lodz, 22 Kopcinskiego Street, 90-153 Lodz, Poland.
Bartosz
B
Bielecki
Marcin P
MP
Mycko
Ewa
E
Tronczyńska
Marek
M
Bieniek
Stephen
S
Sawcer
Efrosini
E
Setakis
Kjartan
K
Benediktsson
Alastair
A
Compston
Krzysztof W
KW
Selmaj
D000328:Adult; D016022:Case-Control Studies; D004247:DNA / Q000097:blood; D019075:Electrophoresis, Capillary; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods* / Q000706:statistics & numerical data; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D011044:Poland / Q000453:epidemiology; D016133:Polymerase Chain Reaction / Q000706:statistics & numerical data
D004247:DNA