Oxidative stress as an initiator of cytokine release and cell damage.
This article characterised the role of oxidative stress in mediating pathological reactions in the lung and the unique antioxidant defences that the lung possesses. The impact of redox balance in regulating inflammatory and immune reactions were discussed, and the impact of enhancing lung antioxidant capacity in animal models of asthma and chronic obstructive pulmonary disease were characterised.
Dept of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, K701, Denver, CO 80206, USA. CrapoJ@njc.org
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Crapo
D000818:Animals; D016923:Cell Death / Q000502:physiology*; D002478:Cells, Cultured; D016207:Cytokines / Q000032:analysis / Q000096:biosynthesis*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D015227:Lipid Peroxidation; D008168:Lung / Q000166:cytology / Q000473:pathology; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011014:Pneumonia / Q000201:enzymology / Q000473:pathology* / Q000503:physiopathology; D011379:Prognosis; D012137:Respiratory System / Q000473:pathology / Q000503:physiopathology; D012680:Sensitivity and Specificity; D013482:Superoxide Dismutase / Q000378:metabolism
D016207:Cytokines; D018836:Inflammation Mediators; D013482:Superoxide Dismutase