New trimethylaluminum-induced mannich-type reaction of hydrazones.
Trimethylaluminum addition to N-monoalkyl or N-monoaryl hydrazones followed by aldehyde addition leads to the formation of N-alkylated hydrazones in a new formal Mannich-type process. Addition compounds were also obtained in moderate yields with ketones. The mechanism as well as possible intermediates involved in the reaction are discussed.
El Kaim
Laurent
L
Laboratoire Chimie et procédés, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75739 Paris 15, France. elkaim@ensta.fr
Grimaud
Laurence
L
Perroux
Yannick
Y
Tirla
Cornelia
C