[Changes of mitochondrial oxidation and phosphorylation in the testes of white rats under excessive supply of sodium nitrate into the organism].
The functional state of mitochondria, obtained from the testicles, after chronic intoxication by sodium nitrate (in a dose of 200 mg/kg during 14; 30 and 90 days) was investigated in experiment on white rats. It was revealed, that in dynamics of changes of mitochondrial oxidation and phosphorylation in the testicles under the excessive supply of sodium nitrate into the organism the determined phases should be marked: on the 14th day of intoxication this is the ascending of rate of respiration, on the 30th and 90th day--separation of the mitochondrial oxidation and ADP phosphorylation. It is supposed, that in pathogenesis of these changes the essential role belongs to nitric oxide production.
Ukrainian Medical Stomatological Academy, Poltava.
S V
SV
Denisenko
V A
VA
Kostenko
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D008297:Male; D008928:Mitochondria / Q000187:drug effects*; D009566:Nitrates / Q000008:administration & dosage / Q000633:toxicity*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000378:metabolism*; D013997:Time Factors
D002273:Carcinogens; D009566:Nitrates; C031618:sodium nitrate