Magnesia-doped HA/beta-TCP ceramics and evaluation of their biocompatibility.
The sintering behavior, mechanical properties and biocompatibility of magnesia (MgO)-doped HA/TCP biphasic ceramics were studied. Pure HA/TCP ceramics showed poor sinterability due to the phase transformation of beta- to alpha-TCP. MgO-doped HA/TCP ceramics showed high density without any phase transformation of beta-TCP up to 1300 degrees C, for MgO dopants incorporated into the beta-TCP preferably and increased thermal stability of beta-TCP. However, the addition of MgO higher than a critical content, suppressed grain growth of HA/TCP ceramics and lowered sinterability. The optimum amount of MgO doping was 1 wt%, which lead 99% relative density and higher mechanical properties than HA or beta-TCP ceramics. From in vitro test and in vivo test, 1 wt% MgO-doped HA/TCP ceramics showed a good biocompatibility without cytotoxicity. After implantation under the muscle of rabbits, beta-TCP phase was dissolved from the surface and a biological apatite covered the surface. These results proved that MgO addition increased drastically the sintering and mechanical properties of HA/beta-TCP ceramics without altering the biological safety and biocompatibility of the original composite.
Ryu
Hyun-Seung
HS
School of Materials Science and Engineering, College of Engineering, Seoul National University, Shinrim-dong San 56-1, Kwanack-Ku, Seoul 151-742, South Korea.
Hong
Kug-Sun
KS
Lee
Jung-Kun
JK
Kim
Deug Joong
DJ
Lee
Jae Hyup
JH
Chang
Bong-Soon
BS
Lee
Dong-ho
DH
Lee
Choon-Ki
CK
Chung
Sung-Soo
SS
D000818:Animals; D000863:Antacids / Q000494:pharmacology*; D001031:Apatites / Q000737:chemistry; D001672:Biocompatible Materials / Q000494:pharmacology*; D018786:Bone Substitutes / Q000737:chemistry; D002118:Calcium / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry; D002460:Cell Line; D002516:Ceramics / Q000737:chemistry / Q000494:pharmacology; D017886:Durapatite / Q000494:pharmacology; D050723:Fractures, Bone; D008274:Magnesium / Q000737:chemistry; D008277:Magnesium Oxide / Q000494:pharmacology*; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning; D008858:Microscopy, Phase-Contrast; D008956:Models, Chemical; D015233:Models, Statistical; D016348:Osseointegration; D010710:Phosphates / Q000737:chemistry; D011817:Rabbits; D013696:Temperature; D013718:Tensile Strength; D013977:Tibia / Q000473:pathology; D014961:X-Ray Diffraction
D000863:Antacids; D001031:Apatites; D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D010710:Phosphates; D008277:Magnesium Oxide; D017886:Durapatite; D008274:Magnesium; C018392:tricalcium phosphate; D002118:Calcium