Role of actin filament network in Burkholderia multivorans invasion in well-differentiated human airway epithelia.
The role of the actin-based cytoskeleton in the internalization process of Burkholderia multivorans by well-differentiated human airway epithelia was investigated by immunohistology and confocal microscopy. Our data suggest that an intact actin cytoskeleton is required for biofilm formation but not single cell entry or paracytosis.
Schwab
Ute E
UE
Cystic Fibrosis/Pulmonary Research and Treatment Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7248, USA. ues3@cornell.edu
Ribeiro
Carla M P
CM
Neubauer
Heiner
H
Boucher
Richard C
RC
D000199:Actins / Q000502:physiology*; D018441:Biofilms; D001980:Bronchi / Q000382:microbiology*; D019117:Burkholderia / Q000472:pathogenicity*; D015638:Cytochalasin D / Q000494:pharmacology; D003599:Cytoskeleton / Q000502:physiology*; D004848:Epithelium / Q000382:microbiology; D006801:Humans; D018613:Microscopy, Confocal; D014132:Trachea / Q000382:microbiology*
D000199:Actins; D015638:Cytochalasin D