Controlled release of vitamin E from thermo-responsive polymeric physico-gel.
Thermo-sensitive copolymer consists of poly(2-ethoxyethyl vinyl ether) and poly(hydroxyethyl vinyl ether) (EOVE200-HOVE400), whose sol-gel transition temperature was 20.5 degrees C, was synthesized and its applicability to a drug delivery system was examined. Vitamin E (VE) was enclosed in EOVE200-HOVE400 and the release of VE was measured by varying the temperature 10<-->30 degrees C. There was no release of VE from EOVE200-HOVE400 at 30 degrees C, while VE was released when the temperature was reduced to 10 degrees C.
Faculty of Science and Technology, Tokyo Universtiy of Science, Yamazaki, Noda, Chiba, Japan.
Masato
M
Ishida
Hideki
H
Sakai
Shinji
S
Sugihara
Sadahito
S
Aoshima
Shoko
S
Yokoyama
Masahiko
M
Abe
D016503:Drug Delivery Systems; D004987:Ethers / Q000737:chemistry; D005079:Excipients; D005782:Gels; D006358:Hot Temperature; D007202:Indicators and Reagents; D008970:Molecular Weight; D014753:Vinyl Compounds / Q000737:chemistry; D014810:Vitamin E / Q000008:administration & dosage* / Q000737:chemistry
D004987:Ethers; D005079:Excipients; D005782:Gels; D007202:Indicators and Reagents; D014753:Vinyl Compounds; C487325:poly(2-ethoxyethyl vinyl ether); C487324:poly(hydroxyethyl vinyl ether); D014810:Vitamin E