Where are the prostate cancer genes?--A summary of eight genome wide searches.
BACKGROUND
There is strong evidence for genetic susceptibility to prostate cancer, but most of the genes underlying this susceptibility remain to be identified.


METHODS
We reviewed the results of eight genome-wide linkage searches based on 1,293 families with multiple cases of prostate cancer.


RESULTS
Across these studies, 11 linkage peaks with LOD scores in excess of 2 were identified. However, no chromosomal region was reported as significant at this level by more than one study and only one corresponded to a peak previously suggested by another group.


CONCLUSIONS
These results indicate that prostate cancer is genetically complex, and that combined analyses of large family sets will be required to evaluate reliably the linkage evidence.
Cancer Research U.K. Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom. douglas@srl.cam.ac.uk
Douglas F
DF
Easton
Daniel J
DJ
Schaid
Alice S
AS
Whittemore
William J
WJ
Isaacs
D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D008297:Male; D011471:Prostatic Neoplasms / Q000235:genetics*
D005819:Genetic Markers