Aldol reactions of dioxanes derived from tartaric acid. A total synthesis of (+)-nephrosteranic acid.
[reaction: see text]. A general enantioselective synthesis of the paraconic acids was developed. The key step was a highly stereoselective aldol reaction between a dioxane dithioester derived from l-tartaric acid and a suitable aldehyde.
Barros
M Teresa
MT
Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, Av. da República, Apartado 127, 2781-901 Oeiras, Portugal.
Maycock
Christopher D
CD
Ventura
M Rita
MR