Hoffman's syndrome: pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report.
The frequency of myopathy in hypothyroidism ranges from 30 to 80%. The major symptoms related are weakness, muscular cramps and myalgia. The pseudohyperthrophic form is called Hoffman's syndrome. The electrophysiological study reveals myopathy, neuropathy or mixed pattern. Laboratorial investigation generally shows increased levels of muscle enzymes and low serum thyroid hormones, with thyrotrophic-stimulating hormone (TSH) elevated. The treatment consists in hormone replacement and the prognosis is good in most of the cases. We report an adult male who developed muscular cramps, myalgia, weakness, pseudohyperthrophy, associated with facial edema and alteration of his voice. The muscle enzymes were increased and T4 was undetectable with a raised level of TSH. The myopathy was the initial manifestation of hypothyroidism in this case.
Vasconcellos
Luiz Felipe Rocha
LF
University Hospital Clementino Fraga Filho, Rio de Janeiro, RJ, Brazil. luizneurol@hotmail.com
Peixoto
Maria Claudia
MC
de Oliveira
Tatiana Nunes
TN
Penque
Glória
G
Leite
Ana Claudia Celestino
AC
D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications; D006801:Humans; D006984:Hypertrophy / Q000209:etiology / Q000473:pathology; D007037:Hypothyroidism / Q000150:complications*; D008297:Male; D018482:Muscle, Skeletal / Q000201:enzymology / Q000473:pathology*; D009135:Muscular Diseases / Q000209:etiology*; D013577:Syndrome