[Conditioning of chronic wounds with proteolytic enzymes].
In the past few years, several different proteolytic enzymes have been shown to be effective in conditioning the chronic wound beds. The use of proteolytic enzymes in wound-bed preparation enables a selective painless debridement. Moreover multiple positive effects on formation of granulation tissue and re-epithelialization have been observed. Therefore, a faster overall healing of chronic wounds may result. Moreover, numerous positive effects on a rapid induction of granulation are discussed. The supporting data do not fulfill the criteria of evidence-based medicine. For most chronic wounds today, enzymatic debridement represents a first choice method especially for outpatients and perhaps in combination with surgical debridement.
Dermatologische Klinik und Poliklinik des Universitätsklinikum Essen, Essen, Germany. joachimdissemond@hotmail.com
J
J
Dissemond
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M
Goos
D000287:Administration, Topical; D002908:Chronic Disease; D003646:Debridement; D006801:Humans; D010447:Peptide Hydrolases / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects; D014947:Wounds and Injuries / Q000188:drug therapy*
D010447:Peptide Hydrolases