Diastolic heart failure: old story, new concepts.
Diastolic heart failure refers to a clinical syndrome characterised by symptoms and signs of congestive heart failure, with a normal or subnormal left ventricular (LV) systolic function associated with alterations in LV diastolic function. Diastolic dysfunction is a pathological condition during which the LV is unable to accept a volume of blood coming back from the lungs appropriate to maintain its stroke volume under normal filling pressure. Three eventually associated mechanisms are responsible for such dysfunction: impaired LV relaxation, increased LV stiffness and loss of normal atrial function. Prevention of LV hypertrophic remodelling should decrease the incidence of diastolic heart failure.
Mercadier
J J
JJ
Departments of Physiology and Cardiology, Groupe Hospitalier Bichat-Claude Bernard, 75018 Paris.
D006333:Heart Failure / Q000473:pathology*; D006801:Humans; D013599:Systole; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling