Fetal bovine serum, but not human serum, inhibits the in vitro cytotoxicity of ET-743 (Yondelis, trabectedin), an example of potential problems for extrapolation of active drug concentrations from in vitro studies.
Tognon
Gianluca
G
Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Frapolli
Roberta
R
Zaffaroni
Marco
M
Erba
Eugenio
E
Zucchetti
Massimo
M
Faircloth
Glynn T
GT
D'Incalci
Maurizio
M
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology*; D002417:Cattle; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003470:Culture Media; D004149:Dioxoles / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology*; D010051:Ovarian Neoplasms / Q000473:pathology; D044967:Serum / Q000737:chemistry*; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin
D018906:Antineoplastic Agents, Alkylating; D003470:Culture Media; D004149:Dioxoles; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; D000077606:Trabectedin