Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meat.
The outbreak of avian influenza H5N1 in Hong Kong in 1997 raised concerns about the potential for the H5 subtype to cause a human pandemic. In 2001 a new H5N1 virus, A/Duck Meat/Anyang/AVL-1/2001 (A/Dkmt), was isolated from imported duck meat in Korea. The pathogenesis of this virus was investigated in mice. A/Dkmt virus had low infectivity but was lethal for mice at high doses, and at lethal doses, the virus replicated in the brains of infected mice. A/Dkmt virus cross-reacted poorly with ferret antisera raised against human H5N1 viruses, but prior infection with A/Dkmt virus protected mice from death after secondary infection with human H5N1 virus.
Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, N.E., Atlanta, GA 30333, USA.
X H
XH
Lu
D
D
Cho
H
H
Hall
T
T
Rowe
I P
IP
Mo
H W
HW
Sung
W J
WJ
Kim
C
C
Kang
N
N
Cox
A
A
Klimov
J M
JM
Katz
D000818:Animals; D001835:Body Weight; D003428:Cross Infection / Q000517:prevention & control; D004196:Disease Outbreaks / Q000662:veterinary; D004372:Ducks / Q000821:virology*; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype; D009980:Influenza A virus / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D005585:Influenza in Birds / Q000503:physiopathology*; D008460:Meat / Q000821:virology*; D051379:Mice; D008807:Mice, Inbred BALB C; D013997:Time Factors; D014779:Virus Replication / Q000502:physiology*; D015047:Zoonoses / Q000453:epidemiology