Cytotoxic and DNA damaging activity of some aporphine alkaloids from Stephania dinklagei.
Six aporphine alkaloids, liriodenine, corydine, isocorydine, atherospermidine, stephalagine and dehydrostephalagine, were isolated by bioassay-guided fractionation of the EtOH extract of the stems of Stephania dinklagei. Liriodenine showed strong cytotoxic activity while corydine and atherospermidine showed DNA damaging activity. Dehydrostephalagine and atherospermidine were isolated from this plant for the first time.
Materials and Chemical Technologies Research Institute, TUBITAK, Marmara Research Center, PO Box 21, 41470 Gebze-Kocaeli, Turkey. ahmet.goren@ume.tubitak.gov.tr
Ahmet C
AC
Gören
Bing-Nan
BN
Zhou
David G
DG
Kingston
D000470:Alkaloids / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001060:Aporphines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004249:DNA Damage / Q000187:drug effects*; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D031607:Stephania
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; D010936:Plant Extracts