On the applicability of a haplotype map to un-assayed populations.
The rationale for mapping all common haplotypes in our species relies on reports of the conservation of haplotype blocks across human populations. Recent findings indicate that these blocks may, at least in part, be a random artifact of genetic drift. This raises the concern that the latter process may challenge the general applicability of a human haplotype map to case-by-case population-specific association studies. We develop arguments indicating that even stochastic drift-originated blocks will, under many conditions, be shared across populations, supporting the utilization of a panhuman haplotype map.
Itsik
I
Pe'er
Jacques S
JS
Beckmann
D000483:Alleles; D002874:Chromosome Mapping; D019295:Computational Biology; D040961:Genetic Drift; D014644:Genetic Variation; D005828:Genetics, Population; D015894:Genome, Human; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide