Is agranulocytosis following infectious mononucleosis caused by autoimmunity?
A patient developed agranulocytosis after Epstein-Barr infection. Bone marrow examination revealed normal myelopoiesis with reduced mature neutrophil polymorphonuclear cells. IgG-specific antineutrophil antibodies (anti-HNA-1a) were found in serum and on polymorphonuclear cells, suggesting that the agranulocytosis after infectious mononucleosis was caused by an autoimmune mechanism.
Auvin
Stéphane
S
Department of Pediatrics, Faculty of Medicine and Children's Hospital, Lille, France. stephane.auvin@free.fr
Dalle
Jean-Hugues
JH
Ganga-Zandzou
Patrice-Serge
PS
Ythier
Hubert
H
D000380:Agranulocytosis / Q000209:etiology* / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology; D002648:Child; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007244:Infectious Mononucleosis / Q000150:complications* / Q000276:immunology; D008297:Male; D009504:Neutrophils / Q000276:immunology
D007074:Immunoglobulin G; D007075:Immunoglobulin M