Interleukin-6 promoter -174 polymorphism and spontaneous preterm birth.
OBJECTIVE
We assessed the relationship between interleukin-6 (IL-6) promoter -174 polymorphism and spontaneous preterm birth (sPTB) less than 34 weeks and the relationship of polymorphism status with race.


METHODS
Polymerase chain reaction was used to evaluate DNA from 156 controls who delivered after spontaneous labor at term and 51 subjects who had sPTB less than 34 weeks.


RESULTS
Among the 156 controls, the C/C variant was present in 30 (19.2%). Among the 51 subjects, the C/C variant was present in 2 (6.3%) (odds ratio 0.17, 95% CI 0.04-0.74). Among white women, the C/C variant was present in 30 (27.2%) controls but only 2 (5.2%) cases. No African American women carried the C/C variant. The racial disparity was statistically significant. (P<.001)


CONCLUSIONS
The IL-6 promoter -174 allelic variant C/C is significantly less frequent among women with sPTB less than 34 weeks. There is a dramatic racial disparity in the distribution of allelic variants of this polymorphism.
University of Pittsburgh School of Medicine, Department of Obstetrics, Magee-Womens Research Institute, Pittsburgh, Pa., USA. hsimhan@mail.magee.edu
Hyagriv N
HN
Simhan
Marijane A
MA
Krohn
James M
JM
Roberts
Adriana
A
Zeevi
Steve N
SN
Caritis
D044383:Black People / Q000235:genetics; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D007752:Obstetric Labor, Premature / Q000235:genetics*; D011110:Polymorphism, Genetic; D011247:Pregnancy; D011401:Promoter Regions, Genetic / Q000235:genetics*; D044465:White People / Q000235:genetics; D001741:Black or African American
D015850:Interleukin-6