Voltage-Gated ion currents of schwann cells in cell culture models of human neurofibromatosis.
K(+) (K) channels play a role in the proliferation of many cell types in normal cells and certain disease states. Several laboratories have studied K currents in cultured Schwann cells from models of the human diseases, neurofibromatosis type 1 (NF1) and neurofibromatosis type 2 (NF2). These diseases are characterized by the growth of Schwann cell tumors. In all cell culture NF models the K current properties differ in tumor-derived and normal Schwann cells. Depending on the model however, the type of K channel abnormality differs. K channels appear to play a role in the proliferation of Schwann cell cultures of these disease models, because a link has been established between K current blockade and the inhibition of Schwann cell proliferation in NF1 and NF2. Differences in the proliferation response of normal Schwann cells to K channel blockers suggest that in vitro regulation of proliferation in neoplastic and normal Schwann cells is complex.
Fieber
Lynne A
LA
Division of Marine Biology and Fisheries, University of Miami Rosentiel School, Miami, Florida, 33149, USA. lfieber@rsmas.miami.edu
D000818:Animals; D001693:Biological Transport, Active; D004195:Disease Models, Animal; D006801:Humans; D017136:Ion Transport / Q000502:physiology; D051379:Mice; D017253:Neurofibromatoses / Q000503:physiopathology*; D011188:Potassium / Q000378:metabolism*; D024642:Potassium Channels, Voltage-Gated / Q000502:physiology*; D012583:Schwann Cells / Q000502:physiology*; D014407:Tumor Cells, Cultured
D024642:Potassium Channels, Voltage-Gated; D011188:Potassium