Construction of medium-ring oxacycloalkenones. Extension towards benzo-fused cyclic ethers.
Application of the intramolecular Kulinkovich cyclopropanation of oxa-omega-alkenoic esters followed by Saegusa oxidation and dehydrohalogenation led to simple or benzo-fused oxacycloalkenones, basic structural elements in a wide range of naturally occurring compounds.
Laboratoire des Carbocycles, UMR 8615, Institut de Chimie Moléculaire et des Matériaux d'Orsay Bât. 420, Université de Paris-Sud, 91405 Orsay, France.
Frédéric
F
Lecornué
Jean
J
Ollivier