The role of endogenous NADPH oxidases in airway and pulmonary vascular smooth muscle function.
Reactive oxygen species generated from NADPH oxidase(s) in airway smooth muscle cells and pulmonary artery smooth muscle cells are important signaling intermediates. Nox4 appears to be the predominant gp91 homologue in these cells. However, expression of NADPH oxidase components is dependent on phenotype, and different homologues may be expressed during different functional states of the cell. NADPH oxidase(s) appear to be important not only for mitogenesis by these cells, but also for O(2) sensing. The regulation of NADPH oxidase(s) in airway and pulmonary artery smooth muscle cells has important implications for the pathobiochemistry of asthma and pulmonary vascular diseases.
Department of Internal Medicine, University of Utah School of Medicine, Medical Service, Salt Lake City, UT, USA. john.hoidal@hsc.utah.edu
John R
JR
Hoidal
S S
SS
Brar
Anne B
AB
Sturrock
Karl A
KA
Sanders
Bruce
B
Dinger
Salvador
S
Fidone
Thomas P
TP
Kennedy
D000818:Animals; D002455:Cell Division; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism; D008956:Models, Chemical; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases / Q000378:metabolism / Q000502:physiology*; D010100:Oxygen / Q000378:metabolism; D010641:Phenotype; D017382:Reactive Oxygen Species; D015398:Signal Transduction
D008562:Membrane Glycoproteins; D017382:Reactive Oxygen Species; C056558:CYBB protein, human; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases; D010100:Oxygen