Effect of channel geometry on the electrostatic potential in acetylcholine channels.
We study the effect of channel geometry on the potential barrier encountered by ions as they permeate the acetylcholine receptor channel. Among the various channel geometries which have been used to represent the acetylcholine receptor channel include the cylinder and the toroidal catenary. The main reasons for those choices appear to be the facilitation of separation of the Poisson equation, rather than biological considerations. We consider a novel and realistic acetylcholine channel geometry, and calculate the electrostatic potential profiles within it, and compare our results with results from other channel geometries.
Department of Mathematics and Computer Science, Eastern Connecticut State University, Willimantic, CT 06226, USA. aidooa@easternct.edu
Anthony Y
AY
Aidoo
D008564:Membrane Potentials / Q000502:physiology; D008956:Models, Chemical; D010539:Permeability; D016012:Poisson Distribution; D011950:Receptors, Cholinergic / Q000737:chemistry* / Q000502:physiology; D055672:Static Electricity
D011950:Receptors, Cholinergic