Primary non-Hodgkin lymphoma of the humerus following traumatic injury: case report.
A case of primary non-Hodgkin lymphoma of the right humerus which occurred in a 21-year-old male patient after an impact to the right shoulder in a car accident in July 1983 is described. Seventeen years after the injury, due to a civil lawsuit, the biopsy material was revised. Immunohistochemical analysis showed CD20 and CD79a positivity on large pleomorphic cells, while small reactive lymphocytes were CD3, Bcl-2 and CD20 positive. Molecular analysis carried out with PCR revealed a monoclonal B-lymphocyte population. The diagnosis of diffuse large peripheral B cell lymphoma of the bone was confirmed. The present case concurs with the literature on primary bone lymphoma, in which the diagnostic problem, trauma-related presentation and an excellent prognosis of malignant tumour are emphasized.
Department of Forensic Medicine, Medical Faculty, University of Rijeka, Croatia.
V
V
Stemberga
R
R
Dobi-Babić
A
A
Bosnar
D
D
Cuculić
D
D
Fuckar
S
S
Stifter
R
R
Kusec
M
M
Marusić-Vrsalović
N
N
Jonjić
D000063:Accidents, Traffic; D000328:Adult; D000911:Antibodies, Monoclonal / Q000378:metabolism; D015703:Antigens, CD / Q000096:biosynthesis; D018951:Antigens, CD20 / Q000096:biosynthesis; D001402:B-Lymphocytes / Q000378:metabolism; D001706:Biopsy; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000209:etiology*; D017252:CD3 Complex / Q000096:biosynthesis; D051925:CD79 Antigens; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis* / Q000209:etiology*; D008297:Male; D016133:Polymerase Chain Reaction; D011379:Prognosis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis; D011947:Receptors, Antigen, B-Cell / Q000096:biosynthesis; D014949:Wounds, Nonpenetrating / Q000175:diagnosis
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018951:Antigens, CD20; D017252:CD3 Complex; D051925:CD79 Antigens; C497881:CD79A protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; D011947:Receptors, Antigen, B-Cell