A one-pot process for the enantioselective synthesis of amines via reductive amination under transfer hydrogenation conditions.
[reaction: see text]. Cyclic amines may be prepared via a sequence of deprotection followed by intramolecular reductive amination of t-Boc-protected amino ketones under asymmetric transfer hydrogenation conditions. In cases where the corresponding imine reaction proceeds with high enantioselectivity, this is reflected in the one-step process.
Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK.
Glynn D
GD
Williams
Richard A
RA
Pike
Charles E
CE
Wade
Martin
M
Wills