Parents' adherence with nebulizer treatment of their children when using an adaptive aerosol delivery (AAD) system.
The objective of this study was to analyze data on parents' adherence to their child's prescribed nebulizer treatment regimen and compliance with the demands of the nebulizer and the face mask. Data on adherence and compliance were recorded in a 24-week double-blind, randomized, parallel-group study with budesonide inhalation suspension in 125 young children with mild to moderate asthma. Budesonide was administered with an Adaptive Aerosol Delivery (AAD) system, which recorded adherence to treatment and compliance with the AAD system. A total of 35,481 treatments were recorded and analyzed. A study questionnaire regarding the parents' and children's acceptance of the AAD system has also been analyzed. The adherence to the treatment regimen was 91.3%, and the compliance with the AAD system was 90.4%. True adherence, the product of adherence and compliance, was 82.5%. Approximately 90% of the parents found the face mask easy to seal and the AAD equipment easy to use, and over 90% of the children accepted it within 1 week. In conclusion, the results indicate that the AAD system could be of real clinical advantage for treatment of asthma in young children.
Profile Therapeutics plc, Bognor Regis, United Kingdom. Kurt.nikander@profiletherapeutics.com
Kurt
K
Nikander
Lars
L
Arheden
John
J
Denyer
Nicolas
N
Cobos
D000280:Administration, Inhalation; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D019819:Budesonide / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004867:Equipment Design; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008397:Masks; D009330:Nebulizers and Vaporizers; D010290:Parents; D011795:Surveys and Questionnaires
D001993:Bronchodilator Agents; D019819:Budesonide