Retention of enzyme gene duplicates by subfunctionalization.
Duplication-degeneration-complementation (DDC) describes a process by which evolving duplicates of a pleiotropic ancestral gene divide up the multiple functions of the ancestor between them (i.e. subfunctionalize), and this ultimately frustrates the rate of pseudogene formation. Focusing explicitly on enzyme-like pleiotropic function, we model DDC driven by sequence divergence between duplicates. The model incorporates an idealized sequence-function mapping in which enzyme-substrate binding affinity is related to hydrophobic versus polar (HP) amino-acid composition of tertiary structure about the binding pocket. In this sense, a transparent coupling between physical-chemical function of an enzyme and sequence evolution is presented.
Stockholm Bioinformatics Center, Department of Biochemistry and Biophysics, Stockholm University, 10691 Stockholm, Sweden. chefnb@sbc.su.se
F N
FN
Braun
D A
DA
Liberles
D004798:Enzymes / Q000235:genetics* / Q000378:metabolism*; D019143:Evolution, Molecular; D020440:Gene Duplication; D008954:Models, Biological; D013329:Structure-Activity Relationship
D004798:Enzymes