Antiasthmatic property of polyherbal preparation E-721 B.
E-721B and its aqueous extract were studied for its antiasthmatic effect in various experimental models using rats and guinea pigs. E-721B produced significant and dose-dependent inhibition of peritoneal mast-cell degranulation induced by compound 48/80 and egg-albumin in sensitised rats. The inhibition was comparable to that with disodium cromoglycate, ketotifen, and prednisolone. E-721B administered 2 h before the experiment and once daily for seven days significantly increased the preconvulsion time of acetylcholine and histamine aerosol-induced bronchospasm. It also significantly reduced mortality in guineapigs produced by egg albumin-induced anaphylactic shock and also reduced bronchoalveolar fluid eosinophil count in the same animals. E-721B significantly inhibited the acetylcholine and histamine-induced contraction of different isolated smooth muscle preparations from rats and guinea pigs. Contrary to these findings E-721B produced dose-dependent contraction of the rat anococcygeus muscle which was blocked by prazosin. Thus our observations establish the antiasthmatic potential of this herbal formulation.
Shah
Gaurang B
GB
K.B. Institute of Pharmaceutical Education & Research, Gandhinagar, India.
Parmar
N S
NS
D000109:Acetylcholine; D000707:Anaphylaxis / Q000139:chemically induced / Q000517:prevention & control; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001986:Bronchial Spasm / Q000139:chemically induced / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006632:Histamine; D007082:Ileum / Q000187:drug effects; D008297:Male; D008407:Mast Cells / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D014132:Trachea / Q000187:drug effects
D018927:Anti-Asthmatic Agents; C462959:E-721B; D010936:Plant Extracts; D006632:Histamine; D000109:Acetylcholine