[Histological clinical features of the primary tumor as prognostic factors in patients with laryngeal carcinoma].
Poland is the country where a constant increase of the incidence of laryngeal cancer and subsequent deaths has been observed during the last 30 years. Despite the large number of therapeutic and histopathological studies that have been performed, there are currently no clinical or morphologic markers available to predict the outcome in patients with laryngeal carcinoma. The aim of the study was to analyse the examinations of tissues from 209 patients who were treated surgically because of advanced carcinoma of the larynx to create a system of tumour evaluation, useful for prognostication. The examinations included routine histology, Anneroth, Batsakis and Luna's modified classification and morphologic grading at the tumour front (TFG). The authors have analysed the tumour biologic and host-related factors to determine the potential usefulness of these features in predicting local and nodal recurrences and survival in patients with laryngeal cancer. This study indicates that the mode and depth of invasion, lymphocytic and eosinophil infiltration, lymph node metastases and score of the tumour front grading and Anneroth, Batsakis and Luna's modified classification are important prognostic parameters in the assessment of recurrences and survival in squamous cell carcinoma of the larynx.
Katedra Otolaryngologii i Klinika Laryngologii Uniwersytetu Medycznego w Łodz.
Katarzyna
K
Starska
Andrzej
A
Kulig
Marek
M
Łukomski
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011044:Poland / Q000453:epidemiology; D015996:Survival Rate