Long-term follow-up of type II membranoproliferative glomerulonephritis in two children.
We report the long-term follow-up of two patients with type II membranoproliferative glomerulonephritis (MPGN). One Patients was treated with high-dose alternate-day prednisolone and the other with dipyridamole. Both had favorable clinical courses over 8.5 and 15.5 years of follow-up, respectively. One patient who showed diffuse proliferative changes lost the urinary abnormalities 2 years after starting treatment. Her follow-up renal biopsies showed histological improvement. In the other patient, a boy, renal biopsy performed 6 years after the onset showed mild mesangial proliferation and a moderate matrix increase. His urine became normal 14 years after onset. Intramembranous electron-dense deposits persisted in these patients over 7 and 6 years of observation, respectively. Patients with type II MPGN are usually difficult to treat and often progress to endstage renal failure. There is, however, a group of patients who have a favorable clinical course.
Iitaka
Kikuo
K
Department of Pediatrics, Yamato City Hospital, 8-3-6 Fukaminishi, Yamato, Kanagawa 242-8602, Japan. kikuo.iitaka@gov.city.yamato.kanagawa.jp
Nakamura
Shinya
S
Moriya
Shunsuke
S
Koshino
Hiroe
H
Iwasaki
Naomi
N
Motoyama
Osamu
O
Sakai
Tadasu
T
D001485:Basement Membrane / Q000473:pathology; D001706:Biopsy; D002648:Child; D004176:Dipyridamole / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D005920:Glomerular Mesangium / Q000473:pathology; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy* / Q000473:pathology / Q000652:urine; D006417:Hematuria; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D011239:Prednisolone / Q000008:administration & dosage; D011507:Proteinuria
D007075:Immunoglobulin M; D004176:Dipyridamole; D011239:Prednisolone