Coronary heart disease clinical manifestation and risk factors in Japanese immigrants and their descendents in the city of São Paulo.
OBJECTIVE
To assess whether a difference exists in coronary heart disease clinical manifestations and the prevalence of risk factors between Japanese immigrants and their descendents in the city of São Paulo.


METHODS
Retrospective analysis of coronary artery disease clinical manifestations and the prevalence of risk factors, comparing 128 Japanese immigrants (Japanese group) with 304 Japanese descendents (Nisei group).


RESULTS
The initial manifestation of the disease was earlier in the Nisei group (mean=53 years), a difference of 12 years when compared with that in the Japanese group (mean=65 years) (P<0.001). Myocardial infarction was the first manifestation in both groups (P=0.83). The following parameters were independently associated with early coronary events: smoking (OR=2.25; 95% CI=1.35-3.77; P<0.002); Nisei group (OR=10.22; 95% CI=5.64-18.5; P<0.001); and female sex (OR=5.04; 95% CI=2.66-9.52; P<0.001).


CONCLUSIONS
The clinical presentation of coronary heart disease in the Japanese and their descendents in the city of São Paulo was similar, but coronary heart disease onset occurred approximately 12 years earlier in the Nisei group than in the Japanese group.
Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Brazil. dcllucesar@incor.usp.br
Reynaldo Vicente
RV
Amato
Luiz Antonio Machado
LA
César
Antonio
A
de Pádua Mansur
Whady Armindo
WA
Hueb
José Renato Martines
JR
Martins
Caio
C
de Brito Vianna
José Antonio Franchini
JA
Ramires
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil / Q000453:epidemiology; D003327:Coronary Disease / Q000208:ethnology*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000208:ethnology; D015228:Hypertriglyceridemia / Q000453:epidemiology; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors