Use of statistical parametric mapping of (18) F-FDG-PET in frontal lobe epilepsy.
OBJECTIVE
Evaluation of the use of statistical parametrical mapping (SPM) of FDG-PET for seizure lateralization in frontal lobe epilepsy.


METHODS
38 patients with suspected frontal lobe epilepsy supported by clinical findings and video-EEG monitoring.


METHODS
Statistical parametrical maps were generated by subtraction of individual scans from a control group, formed by 16 patients with negative neurological/psychiatric history and no abnormalities in the MR scan. The scans were also analyzed visually as well as semiquantitatively by manually drawn ROIs.


RESULTS
SPM showed a better accordance to the results of surface EEG monitoring compared with visual scan analysis and ROI quantification. In comparison with intracranial EEG recordings, the best performance was achieved by combining the ROI based quantification with SPM analysis.


CONCLUSIONS
These findings suggest that SPM analysis of FDG-PET data could be a useful as complementary tool in the evaluation of seizure focus lateralization in patients with supposed frontal lobe epilepsy.
Klinik für Strahlenheilkunde, Campus Virchow-Klinikum Medizinische, Fakultät Charité der Humboldt-Universität zu Berlin, Augustenburger Platx 1, 13353 Berlin, Germany. michail.plotkin@charite.de
M
M
Plotkin
H
H
Amthauer
M
M
Merschhemke
L
L
Lüdemann
E
E
Hartkop
J
J
Ruf
M
M
Gutberlet
H
H
Bertram
H-J
HJ
Meencke
R
R
Felix
St
S
Venz
D000293:Adolescent; D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D002648:Child; D003937:Diagnosis, Differential; D004569:Electroencephalography; D017034:Epilepsy, Frontal Lobe / Q000145:classification / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D012016:Reference Values; D015203:Reproducibility of Results; D014055:Tomography, Emission-Computed; D014741:Video Recording
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18