Significant elevation of urinary trypsin inhibitor in patients with brain contusion--a preliminary report.
Urinary trypsin inhibitor (UTI) is a protease inhibitor, which is produced in the liver. The correlation between UTI level and head injury has not been evaluated. This study was designed to investigate UTI levels in patients with severe head injury. We measured UTI in the urine of patients with brain contusion. UTI was significantly higher in those patients compared to the control group. The results suggest that UTI may be useful for assessing the severity of head injury and also as a treatment marker in patients with brain contusion.
Sakai
Keiichi
K
Department of Neurosurgery, Shinshu University School of Medicine, Asahi 3-1-1, Matsumoto, Japan. skeiichi@hsp.md.shinshu-u.ac.jp
Okudera
Hiroshi
H
Hongo
Kazuhiro
K
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000652:urine; D001930:Brain Injuries / Q000175:diagnosis / Q000503:physiopathology / Q000652:urine*; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D004660:Encephalitis / Q000503:physiopathology / Q000517:prevention & control / Q000652:urine; D005260:Female; D015600:Glasgow Coma Scale; D006023:Glycoproteins / Q000032:analysis / Q000652:urine*; D016489:Head Injuries, Closed / Q000175:diagnosis / Q000503:physiopathology / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity; D015854:Up-Regulation / Q000502:physiology; D055815:Young Adult
D015415:Biomarkers; D016207:Cytokines; D006023:Glycoproteins; C028665:urinastatin