Immunity against Boophilus annulatus induced by the Bm86 (Tick-GARD) vaccine.
Friesian cattle were immunized with two inoculations of anti-tick Bm86 (Tick-GARD) vaccine and were challenged 30 or 90 d later with Boophilus annulatus larvae derived from 1.2 g of eggs. No nymphs or adult ticks were found on the immunized cattle during four weeks after challenge. Repeated infestations (2 to 4) with larvae on three other calves during a period of 160 and 390 d after the immunization did not result in development of nymphal and adult stages. In control, non-immunized cattle infested with corresponding batches of larvae 1380 to 4653 replete adult female ticks were collected. Larvae issued from Babesia bovis-infected female ticks transmitted the infection to Bm86-immunized cattle, but the progeny of B. bigemina-infected females did not. Since B. bigemina is transmitted exclusively by nymphal stages of Bo. annulatus these results support the observation that immunity induced by Bm86 affects the larval stage of this tick.
Veterinary Services and Animal Health, Kimron Veterinary Institute, Ministry of Agriculture and Rural Development, POB 12, 50250 Bet Dagan, Israel. pipanoi@int.gov.il
Eugene
E
Pipano
Eugene
E
Alekceev
Felicia
F
Galker
Lea
L
Fish
Michael
M
Samish
Varda
V
Shkap
D000818:Animals; D016793:Babesia bovis / Q000276:immunology; D001404:Babesiosis / Q000276:immunology / Q000517:prevention & control / Q000635:transmission; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000469:parasitology / Q000517:prevention & control*; D005260:Female; D007114:Immunization / Q000662:veterinary*; D026863:Ixodidae / Q000276:immunology* / Q000469:parasitology; D008562:Membrane Glycoproteins / Q000276:immunology*; D011994:Recombinant Proteins; D013984:Tick Infestations / Q000276:immunology* / Q000517:prevention & control / Q000662:veterinary*; D017282:Tick-Borne Diseases / Q000276:immunology / Q000517:prevention & control / Q000635:transmission; D014612:Vaccines / Q000276:immunology* / Q000627:therapeutic use
C085065:BM86 protein, Boophilus; D008562:Membrane Glycoproteins; D011994:Recombinant Proteins; D014612:Vaccines