Alterations in the phenotype of CMV-specific and total CD8+ T-cell populations in Wegener's granulomatosis.
Wegener's granulomatosis (WG) is an autoimmune disease of as yet unknown etiology. To date it has remained obscure what causes WG or determines disease progression. Case reports suggest that viral infections such as cytomegalovirus (CMV) reactivation may contribute to disease flares. In this study we found a skewing of the phenotype of CMV-specific CD8+tet(ramer)+ T-cells in WG. A marked proportion of these cells displayed a late differentiated "effector memory" T-cell phenotype with decreased expression of CD28 and CD62L, and heterogeneous CD27 expression, features which were also seen in CD8+tet- T-cells in WG, but not in controls. Our results might reflect profound generalized changes in the CD8+ T-cell compartment also affecting virus-specific T-cell responses in WG.
Department of Rheumatology, University Hospital of Schleswig-Holstein, Campus Luebeck, and Rheumaklinik Bad Bramstedt, 23538 Luebeck, Germany. lamprecht@rheuma-zentrum.de
Peter
P
Lamprecht
Ana L
AL
Vargas Cuero
Antje
A
Muller
Elena
E
Csernok
Jan
J
Voswinkel
Matthias
M
Maass
Werner
W
Solbach
Wolfgang L
WL
Gross
Paul
P
Klenerman
D036541:ADP-ribosyl Cyclase / Q000276:immunology; D051997:ADP-ribosyl Cyclase 1; D015703:Antigens, CD / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D018106:CD28 Antigens / Q000276:immunology; D018959:CD57 Antigens / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D002454:Cell Differentiation / Q000187:drug effects / Q000276:immunology; D003587:Cytomegalovirus / Q000276:immunology* / Q000472:pathogenicity; D003586:Cytomegalovirus Infections / Q000150:complications*; D015536:Down-Regulation / Q000276:immunology; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000097:blood / Q000276:immunology* / Q000821:virology; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D019041:L-Selectin / Q000276:immunology; D037181:Lectins, C-Type; D008297:Male; D008562:Membrane Glycoproteins; D010641:Phenotype; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000276:immunology; D015854:Up-Regulation / Q000276:immunology; D000099192:CD69 Antigens
D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D018106:CD28 Antigens; D018959:CD57 Antigens; D006684:HLA-DR Antigens; D007166:Immunosuppressive Agents; D019041:L-Selectin; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7; D000099192:CD69 Antigens; C498154:CD38 protein, human