Role of stretch in activation of smooth muscle cell lineage.
Mechanical force is a critical modulator of smooth muscle (SM) function and gene expression. Very little is known, however, about its contribution to SM myogenesis. This review presents and discusses what has been learned about the role of mechanical force in inducing SM myogenesis and some of the signaling mechanisms involved in this process.
Department of Pathology, Wayne State University, School of Medicine, Detroit, MI 48201, USA
Sandhya
S
Jakkaraju
Xiaoning
X
Zhe
Lucia
L
Schuger
D002454:Cell Differentiation; D019070:Cell Lineage; D048429:Cell Size; D003911:Dextrans; D024510:Muscle Development; D032389:Myocytes, Smooth Muscle / Q000378:metabolism / Q000502:physiology*; D011312:Pressure; D013314:Stress, Mechanical
D003911:Dextrans