Voxelwise mapping of magnetic resonance ventilation-perfusion ratio in a porcine model by multimodality registration: technical note.
OBJECTIVE
The purpose of this study was to demonstrate the construction of voxelwise ventilation-perfusion (V/Q) ratio maps in a porcine model by nonrigidly aligning the respective ventilation and perfusion images using a multimodality registration algorithm.


METHODS
The first-pass contrast agent technique for a blood flow map and 3He used for ventilation imaging were performed using a normal porcine model. The registered 3He-ventilation image was then aligned to the blood flow map using a multimodality registration algorithm. The voxelwise V/Q ratios were calculated by dividing the registered 3He-ventilation image by the blood flow map. The V/Q ratios were also semi-logarithmically scatter-plotted against the number of voxels.


RESULTS
From perfusion magnetic resonance images, a voxel-by-voxel blood flow map was produced. Registered 3He ventilation image was successfully obtained as well as V/Q ratio map. Plots of the V/Q ratios obtained by this registration approach were similar to the logarithmic normal distribution.


CONCLUSIONS
Registration of MR perfusion and ventilation images can potentially enable quantitative evaluation of regional pulmonary function and thus yield deeper insight into the physiology and pathophysiology of the lung.
Hasegawa
Ichiro
I
Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA.
Uematsu
Hidemasa
H
Gee
James C
JC
Rogelj
Peter
P
Song
Hee Kwon
HK
Nakatsu
Masashi
M
Takahashi
Masaya
M
Gefter
Warren B
WB
Hatabu
Hiroto
H
D000818:Animals; D003287:Contrast Media; D006371:Helium; D007554:Isotopes; D008168:Lung / Q000502:physiology; D008279:Magnetic Resonance Imaging; D011652:Pulmonary Circulation; D012123:Pulmonary Ventilation; D013552:Swine; D014692:Ventilation-Perfusion Ratio
D003287:Contrast Media; D007554:Isotopes; D006371:Helium