Cell cycle control in glomerular disease.
Glomerular diseases are a leading caused of kidney failure. The three resident glomerular cell types respond differently to injury, which includes proliferation, hypertrophy, apoptosis and de-differentiation. Each leads to glomerular scarring, and a decline in renal function. Studies have shown that these events are critically controlled by cell cycle regulatory proteins, providing potential targets for the development of future therapeutics.
Department of Medicine, Division of Nephrology, University of Hamburg, Hamburg, Germany.
Gunter
G
Wolf
Stuart J
SJ
Shankland
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D018797:Cell Cycle Proteins / Q000187:drug effects / Q000378:metabolism*; D005920:Glomerular Mesangium / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology; D005921:Glomerulonephritis / Q000188:drug therapy / Q000201:enzymology* / Q000503:physiopathology; D006801:Humans; D006984:Hypertrophy / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D023421:Models, Animal
D018797:Cell Cycle Proteins