Discriminative stimulus effects of the cannabinoid antagonist, SR 141716A, in delta -sup-9-tetrahydrocannabinol-treated rhesus monkeys.
This study examined whether the cannabinoid antagonist, SR 141716A, could be established as a discriminative stimulus in rhesus monkeys treated with delta -sup-9-tetrahydrocannabinol (delta -sup-9-THC). Stimulus control was established with SR 141716A (1.0 mg/kg) in 3 delta -sup-9-THC-treated monkeys (1.12 mg/kg/day) in 113-124 sessions. The SR 141716A discriminative stimulus was dose related, attenuated by an acute injection of delta -sup-9-THC, and not mimicked by cocaine or ketamine. SR 141716A-appropriate responding occasioned by temporary discontinuation of delta -sup-9-THC treatment was attenuated by delta -sup-9-THC and not ketamine. The SR 141716A discriminative stimulus in delta -sup-9-THC-treated monkeys appears to be mediated by cannabinoid receptors and could be related to delta -sup-9-THC withdrawal.
Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA. mcmahonl@uthscsa.edu
Lance R
LR
McMahon
Charles P
CP
France
D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal; D002186:Cannabinoids / Q000037:antagonists & inhibitors*; D003042:Cocaine / Q000494:pharmacology; D004193:Discrimination Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D013759:Dronabinol / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D007649:Ketamine / Q000494:pharmacology; D008253:Macaca mulatta; D008297:Male; D010775:Photic Stimulation; D010880:Piperidines / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology*; D000077285:Rimonabant; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000503:physiopathology
D000777:Anesthetics; D002186:Cannabinoids; D010880:Piperidines; D011619:Psychotropic Drugs; D011720:Pyrazoles; D007649:Ketamine; D013759:Dronabinol; D003042:Cocaine; D000077285:Rimonabant