Conjugate adaptation of saccadic gain in non-human primates with strabismus.
In this study, we have used the double-step paradigm to test saccadic gain adaptation during monocular viewing in one normal monkey, two monkeys with exotropia, and one monkey with esotropia. In this paradigm, the target for the saccade is displaced during the saccade, resulting in a consistent visual error. Studies in normal humans and monkeys have shown that the brain responds to this consistent visual error by gradually changing saccade gain. Using this technique, we were able to elicit adaptation in both the viewing eye and the nonviewing eye in the normal monkey and in monkeys with strabismus. The rate of adaptation was not significantly different in the viewing and nonviewing eyes in the normal and strabismic monkeys. The magnitude of adaptation as calculated by a percentage change in gain was also not significantly different in the viewing and the nonviewing eyes in the normal and strabismic monkeys. Our data show that animals with strabismus retain the ability to elicit a conjugate adaptation of saccades using this mechanism. We also suggest that the double-step paradigm elicits a conjugate adaptation of saccades whether the animal is viewing monocularly (our studies) or binocularly (data published in literature).
Division of Visual Science, Yerkes National Primate Research Center, Department of Neurology, Emory University, Atlanta, Georgia 30322, USA. vdas@rmy.emory.edu
Vallabh E
VE
Das
Seiji
S
Ono
Ronald J
RJ
Tusa
Michael J
MJ
Mustari
D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D008253:Macaca mulatta; D010775:Photic Stimulation / Q000379:methods; D012438:Saccades / Q000502:physiology*; D013285:Strabismus / Q000503:physiopathology*