Genetic relatedness of recently collected Spanish respiratory tract Streptococcus pneumoniae isolates with reduced susceptibility to amoxicillin.
Of Streptococcus pneumoniae isolates from 17 hospitals, 9.8% were amoxicillin nonsusceptible (MIC > or = 4 microg/ml). The genetic relatedness of 138 isolates was studied by pulsed-field gel electrophoresis. Although 44 different clones were detected, more than 62% of these isolates were related to four clones (Spain(23F)-1, Spain(6B)-2, Spain(9V)-3, and Spain(14)-5).
Microbiology Department, Hospital Donostia, San Sebastián, Spain. mikrobiol@terra.es
E
E
Pérez-Trallero
J M
JM
Marimón
A
A
González
C
C
García-Rey
L
L
Aguilar
D000658:Amoxicillin / Q000494:pharmacology*; D003001:Cloning, Molecular; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance / Q000235:genetics*; D011008:Pneumococcal Infections / Q000382:microbiology*; D012141:Respiratory Tract Infections / Q000382:microbiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013030:Spain; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000235:genetics*
D004269:DNA, Bacterial; D000658:Amoxicillin