Premixed calcium-phosphate cement pastes.
A self-hardening calcium-phosphate cement (CPC) containing Ca(4)(PO(4))(2)O and CaHPO(4) has been shown in clinical studies to be efficacious for repairing bone defects. This and several other similar CPCs harden in 10 min with the use of a phosphate solution as the liquid and form hydroxyapatite (HA) as the product. The present study investigated the properties of water-free, glycerol-containing CPC pastes that are stable in the package and would harden only after being delivered to a defect site where glycerol-tissue fluids exchange occurs. Premixed CPC pastes were prepared by combining cement liquids containing glycerol and various amounts of hydroxypropyl methylcellulose/Na(2)HPO(4), with CPC powders that contained (1) Ca(4)(PO(4))(2)O and CaHPO(4), (2) alpha-Ca(3)(PO(4))(2) and CaCO(3), or (3) CaHPO(4) and Ca(OH)(2). The hardening times and 1-d and 7-d diametral tensile strengths were measured on samples that hardened in an in vitro model that allowed exchange of glycerol and physiologic-like solution (PLS) through fritted glass slides at 37 degrees C. All pastes had excellent washout resistance; they remained intact and hardened while immersed in PLS and formed HA as products. Newman-Keuls multiple comparison tests indicated that the Na(2)HPO(4) amount, not the hydroxypropyl methylcellulose (HMC) amount, significantly (p < 0.05) affected the strength and hardening time. Although the premixed CPCs generally have longer hardening times and lower strengths, these pastes have excellent washout resistance before hardening and can be prepared in advance under well-controlled conditions.
American Dental Association Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, Gaithersburg, Maryland 20899, USA. shozo.takagi@nist.gov
Shozo
S
Takagi
Laurence C
LC
Chow
Satoshi
S
Hirayama
Akiyoshi
A
Sugawara
D001826:Body Fluids; D001843:Bone Cements / Q000138:chemical synthesis* / Q000592:standards; D002130:Calcium Phosphates; D017886:Durapatite / Q000138:chemical synthesis*; D005990:Glycerol; D010710:Phosphates; D013499:Surface Properties; D013718:Tensile Strength; D013997:Time Factors
D001843:Bone Cements; D002130:Calcium Phosphates; D010710:Phosphates; C485838:calcium phosphate, monobasic, anhydrous; D017886:Durapatite; C020243:calcium phosphate; D005990:Glycerol; C018279:sodium phosphate