Sulfoxide-directed thermal intramolecular [4 + 2] cycloadditions between 2-sulfinyl butadienes and unactivated alkynes.
2-Sulfinyl butadienes tethered to unactivated alkynes undergo a facile thermal intramolecular Diels-Alder cycloaddition, often at room temperature, to produce cyclohexa-1,4-dienes with good selectivities, in high yields, and preserving the valuable vinyl sulfoxide functionality.
Instituto de Química Orgánica, CSIC, Juan de la Cierva, 3, 28006 Madrid, Spain.
Roberto
R
Fernández de la Pradilla
Raquel
R
Baile
Mariola
M
Tortosa