A sense of life: computational and experimental investigations with models of biochemical and evolutionary processes.
We collaborate in a research program aimed at creating a rigorous framework, experimental infrastructure, and computational environment for understanding, experimenting with, manipulating, and modifying a diverse set of fundamental biological processes at multiple scales and spatio-temporal modes. The novelty of our research is based on an approach that (i) requires coevolution of experimental science and theoretical techniques and (ii) exploits a certain universality in biology guided by a parsimonious model of evolutionary mechanisms operating at the genomic level and manifesting at the proteomic, transcriptomic, phylogenic, and other higher levels. Our current program in "systems biology" endeavors to marry large-scale biological experiments with the tools to ponder and reason about large, complex, and subtle natural systems. To achieve this ambitious goal, ideas and concepts are combined from many different fields: biological experimentation, applied mathematical modeling, computational reasoning schemes, and large-scale numerical and symbolic simulations. From a biological viewpoint, the basic issues are many: (i) understanding common and shared structural motifs among biological processes; (ii) modeling biological noise due to interactions among a small number of key molecules or loss of synchrony; (iii) explaining the robustness of these systems in spite of such noise; and (iv) cataloging multistatic behavior and adaptation exhibited by many biological processes.
Mishra
Bud
B
Department of Computer Science and Mathematics, Courant Institute of Mathematical Sciences, New York University, New York, New York, USA. mishra@nyu.edu
Daruwala
Raoul-Sam
RS
Zhou
Yi
Y
Ugel
Nadia
N
Policriti
Alberto
A
Antoniotti
Marco
M
Paxia
Salvatore
S
Rejali
Marc
M
Rudra
Archisman
A
Cherepinsky
Vera
V
Silver
Naomi
N
Casey
William
W
Piazza
Carla
C
Simeoni
Marta
M
Barbano
Paolo
P
Spivak
Marina
M
Feng
Jiawu
J
Gill
Ofer
O
Venkatesh
Mysore
M
Cheng
Fang
F
Sun
Bing
B
Ioniata
Iuliana
I
Anantharaman
Thomas
T
Hubbard
E Jane Albert
EJ
Pnueli
Amir
A
Harel
David
D
Chandru
Vijay
V
Hariharan
Ramesh
R
Wigler
Michael
M
Park
Frank
F
Lin
Shih-Chieh
SC
Lazebnik
Yuri
Y
Winkler
Franz
F
Cantor
Charles R
CR
Carbone
Alessandra
A
Gromov
Mikhael
M
D000818:Animals; D001671:Biochemistry / Q000379:methods; D002477:Cells / Q000166:cytology / Q000378:metabolism; D019295:Computational Biology / Q000379:methods*; D019143:Evolution, Molecular; D006801:Humans; D008954:Models, Biological; D008957:Models, Genetic; D011687:Purines / Q000378:metabolism; D012984:Software; D013597:Systems Analysis
D011687:Purines