[Neural stem cells: perspectives of clinical application].
The prognosis for many patients with central nervous system (CNS) diseases has recently improved, especially due to enormous development of medical sciences. Nevertheless there are still pathologies very difficult to cure. It is caused mainly by the irreversibility of CNS lesions, that even after ceasing the primary pathological process--lead to deep functional deterioration. Hopefully this will change in the future thanks to the discovery of the stem cell population located in the CNS. These cells have to reproduce cytoarchitecture and CNS function. The range of possible use of the therapy based on neural stem cells (NSC) appears unlimited. The most advanced laboratory trials are focused on neurodegenerative diseases with very promising results The second field of clinical neuroscience that NSC can play a key role in are injuries of the CNS, with special emphasis on spinal cord injuries which are still an unresolved problem of neurotraumatology. Adding to the possible roles of NSC--they may act as transporters of transgenes in case of metabolic or neoplasmatic diseases. The interest of many groups of scientists in biological and clinical use of NSC appears to be justified. Authors present advancement and possible ways of development of therapeutic methods based on NSC.
Maciaczyk
Jarosław
J
Katedra i Klinika Neurochirurgii i Neurotraumatologii Akademii Medycznej im. Ludwika Rydygiera w Bydgoszczy.
Swietaszczyk
Cyprian
C
Tafil-Klawe
Małgorzata
M
Kasprzak
Heliodor A
HA
D006801:Humans; D019636:Neurodegenerative Diseases / Q000628:therapy*; D009474:Neurons / Q000637:transplantation*; D013119:Spinal Cord Injuries / Q000628:therapy; D033581:Stem Cell Transplantation / Q000379:methods*