[CYP1A2, NAT2, and GSTM1 phenotype/genotype modulate human exposure and various environmental mutagens: our experience].
Since some years in our research group has been studied the influence of metabolic genotypes on two biomarkers of genotoxic risk (BPDE-DNA adducts and urinary mutagenicity) in humans exposed to polycyclic aromatic hydrocarbons (PAHs) and aromatic amines. The aim was to identify possible genetic susceptible factors capable of modulating individual response to these carcinogens. Humans exposed to PAHs: dermatological patients therapeutically treated with coal tar based ointments (CT), coke oven workers and chimney sweeps. People exposed to aromatic amines will be volunteers after a meal of pan-fried hamburgers and smokers. An overview of the results we found until now will be presented.
Dipartimento di Medicina Ambientale e Sanità Pubblica, Sezione Medicina del Lavoro, Università degli Studi di Padova.
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D015123:7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide / Q000378:metabolism*; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D018736:DNA Adducts / Q000652:urine*; D004781:Environmental Exposure; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D009153:Mutagens / Q000378:metabolism*; D010641:Phenotype; D011084:Polycyclic Aromatic Hydrocarbons / Q000652:urine*
D015123:7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; D001191:Arylamine N-Acetyltransferase; D019388:Cytochrome P-450 CYP1A2; D018736:DNA Adducts; D005982:Glutathione Transferase; D009153:Mutagens; D011084:Polycyclic Aromatic Hydrocarbons; C478900:NAT2 protein, human