Marine pharmacology in 2000: marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antituberculosis, and antiviral activities; affecting the cardiovascular, immune, and nervous systems and other miscellaneous mechanisms of action.
During 2000 research on the pharmacology of marine chemicals involved investigators from Australia, Brazil, Canada, Egypt, France, Germany, India, Indonesia, Israel, Italy, Japan, the Netherlands, New Zealand, Phillipines, Singapore, Slovenia, South Korea, Spain, Sweden, Switzerland, United Kingdom, and the United States. This current review, a sequel to the authors' 1998 and 1999 reviews, classifies 68 peer-reviewed articles on the basis of the reported preclinical pharmacologic properties of marine chemicals derived from a diverse group of marine animals, algae, fungi, and bacteria. Antibacterial, anticoagulant, antifungal, antimalarial, antiplatelet, antituberculosis, or antiviral activity was reported for 35 marine chemicals. An additional 20 marine compounds were shown to have significant effects on the cardiovascular and nervous system, and to possess anti-inflammatory or immunosuppressant properties. Finally, 23 marine compounds were reported to act on a variety of molecular targets and thus could potentially contribute to several pharmacologic classes. Thus, as in 1998 and 1999, during 2000 pharmacologic research with marine chemicals continued to contribute potentially novel chemical leads to the ongoing global search for therapeutic agents in the treatment of multiple disease categories.
Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, IL 60515, USA. amayer@midwestern.edu
Alejandro M S
AM
Mayer
Mark T
MT
Hamann
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification; D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification; D001685:Biological Factors / Q000737:chemistry* / Q000302:isolation & purification*; D002317:Cardiovascular Agents / Q000737:chemistry / Q000302:isolation & purification; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification; D008386:Marine Biology; D010598:Pharmacognosy / Q000639:trends*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000925:Anticoagulants; D000935:Antifungal Agents; D000962:Antimalarials; D000995:Antitubercular Agents; D000998:Antiviral Agents; D001685:Biological Factors; D002317:Cardiovascular Agents; D007166:Immunosuppressive Agents; D010975:Platelet Aggregation Inhibitors