Novel poly(amino ester)s obtained from Michael addition polymerizations of trifunctional amine monomers with diacrylates: safe and efficient DNA carriers.
Novel biodegradable poly(amino ester)s containing secondary and tertiary amines in the backbones were obtained from the Michael addition polymerizations of trifunctional amine monomers with diacrylates, and showed high transfection efficiency for the delivery of DNA comparable to those of polyethylenimine (PEI) and low cytotoxicity.
Institute of Materials Research and Engineering, 3 Research Link, Singapore 117602. ye-liu@imre.a-star.edu.sg
Ye
Y
Liu
Decheng
D
Wu
Yuexia
Y
Ma
Guping
G
Tang
Shu
S
Wang
Chaobin
C
He
Taishung
T
Chung
Suathong
S
Goh
D000179:Acrylates / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D001673:Biodegradation, Environmental; D002460:Cell Line; D004247:DNA / Q000008:administration & dosage; D005822:Genetic Vectors / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D006801:Humans; D015394:Molecular Structure; D010957:Plasmids; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D011091:Polyesters / Q000138:chemical synthesis / Q000633:toxicity; D011094:Polyethyleneimine / Q000633:toxicity; D014162:Transfection / Q000379:methods*
D000179:Acrylates; D000588:Amines; D011073:Polyamines; D011091:Polyesters; D011094:Polyethyleneimine; D004247:DNA