[Cytokine regulation of immune response in patients with chronic hepatitis C].
To evaluate content of interleukines (IL-1, IL-2, IL-4 and IL-6) and tumor necrosis factor (TNF) in patients with chronic hepatitis C (CHC), 72 CHC patients (37 males and 35 females, mean age 37.2 +/- 4.8 years) were examined. The control group consisted of 20 healthy donors (mean age 25.5 +/- 2.3 years). It was found that low levels of IL-1, IL-2, IL-6, TNF evidence for weak immune response which means long-term virus circulation and active replication. The highest concentrations of the above cytokines correspond to low replicative activity while high IL-4 levels point to active virus replication. IL-1, IL-2, IL-4, IL-6, TNF were high in patients with high cytolysis. Cytokine regulation of immune response can be used for assessment of the effectiveness of antiviral and immunocorrective therapy.
O V
OV
Korochkina
D M
DM
Sobchak
E A
EA
Mikhaĭlova
E A
EA
Monakova
D000293:Adolescent; D000328:Adult; D016207:Cytokines / Q000097:blood*; D005260:Female; D018937:Hepatitis C Antibodies / Q000097:blood; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D016207:Cytokines; D018937:Hepatitis C Antibodies; D014409:Tumor Necrosis Factor-alpha