Comparison of humoral immune responses in dairy heifers vaccinated with 3 different commercial vaccines against bovine viral diarrhea virus and bovine herpesvirus-1.
A randomized clinical trial was conducted to compare the humoral immune response to 3 different commercial vaccines in dairy heifers housed in 3 different dairy farms in Quebec. All heifers were seronegative to type 1 bovine viral diarrhea virus (BVDV) (Singer strain), type 2 BVDV (NVSL 125c strain), and bovine herpesvirus-1 (BHV-1) at the beginning of the trial. In addition, control heifers in group 1 remained seronegative to the 2 viruses till the end of the trial. Significant differences in humoral immune responses occurred among the 3 commercial vaccines at 4 weeks and 6 months following vaccination. The vaccine in group 2 elicited higher mean antibody titers and seroconversion rates to both type 1 and type 2 BVDV than that in groups 3 or 4. Vaccines in groups 2 and 3 induced higher mean antibody titers to BHV-1 than did the vaccine in group 4.
Départment de sciences cliniques, Faculté de médecine vétérinaire, Université de Montréal, C.P. 5000, St-Hyacinthe, Quebec J2S 7C6.
Luc
L
DesCôteaux
Dominique
D
Cécyre
Johanne
J
Elsener
Guy
G
Beauchamp
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis*; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000517:prevention & control; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D001908:Diarrhea Viruses, Bovine Viral / Q000276:immunology*; D005260:Female; D006566:Herpesviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D007242:Herpesvirus 1, Bovine / Q000276:immunology*; D011792:Quebec; D014611:Vaccination / Q000662:veterinary; D017778:Vaccines, Combined / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D017778:Vaccines, Combined; D014765:Viral Vaccines