The cytogenetic investigation on peripheral blood lymphocytes of a patient with thyroid cancer.
The cytogenetic investigation of a patient with follicular cancer in the left lobe of the thyroid gland was made. The study was carried out on blood lymphocytes as described earlier (1) before and after hemithyroidectomy and in different terms during the therapeutic treatment. The great number of cells with polyploid and hyperaneuploid (13% and 5% correspondingly) were revealed in the patient on the day before the operation and confirmed malignant character of the tumour, which was confirmed histologically. It is believed that cytogenetic markers as trisomies 4-th chromosome or/and X chromosome, detected in hyperaneuploids cells before the beginning of a treatment, might be specific markers for follicular thyroid cancer (FTC). The cytogenetic examination of the patient, carried out on peripheral blood lymphocytes in dynamics, allowed to observe changes of background chromosomal breaches under influence of surgical and therapeutic treatment and to estimate their efficiency.
Monakhov
A S
AS
N.N.Petrov Research Institute, Laboratory of Oncogenetic, St. Petersburg, Russia. monah39@rol.ru
Wagner
R I
RI
D000328:Adult; D000782:Aneuploidy; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D041321:Chromosomes, Human, X / Q000235:genetics; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism* / Q000473:pathology; D013964:Thyroid Neoplasms / Q000235:genetics*; D014314:Trisomy / Q000235:genetics