A novel sunscreen agent having antimelanoma activity.
A novel series of eight dibenzoylmethane derivatives having both sunscreen and cytotoxic activity has been obtained by derivatizing commercial dibenzoyl methanes. Four human cancer cell lines (MCF 7 (breast), NCI ADR (breast expressing the multidrug resistance phenotype), NCI 460 (lung) and UACC 62 (melanoma)) were used for the cytotoxic assay. Eight among the 19 dibenzoylmethane derivatives showed cytotoxicity against these four cell lines. Absorption spectroscopies revealed that these compounds can be used as sunscreens against UV radiation.
Nogueira
Marisa A
MA
Instituto de Química, Universidade Estadual de Campinas, CP 6154, SP, 13083-970 Campinas, Brazil.
Magalhães
Eva G
EG
Magalhães
Aderbal F
AF
Biloti
Débora N
DN
Laverde
Antonio
A
Pessine
Francisco B T
FB
Carvalho
João E
JE
Kohn
Luciana K
LK
Antônio
Márcia A
MA
Marsaioli
Anita J
AJ
D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D001565:Benzoates / Q000737:chemistry / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D047188:Chalcones; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000517:prevention & control; D012878:Skin Neoplasms / Q000517:prevention & control; D013473:Sunscreening Agents / Q000737:chemistry / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D001565:Benzoates; D047188:Chalcones; D013473:Sunscreening Agents; C061481:dibenzoylmethane