New silica-immobilized chiral amino alcohol for the enantioselective addition of diethylzinc to benzaldehyde.
[reaction: see text] A readily available chiral amino alcohol has been immobilized on silica by sol-gel synthesis and grafting. The solid prepared according to the latter method led to the best enantioselectivity (77% ee) described for the asymmetric addition of diethylzinc to benzaldehyde using inorganic solids.
Departamento de Química Orgánica, Instituto de Ciencia de Materiales de Aragón, Facultad de Ciencias, Universidad de Zaragoza-CSIC, E-50009 Zaragoza, Spain.
José M
JM
Fraile
José A
JA
Mayoral
Jorge
J
Serrano
Miquel A
MA
Pericàs
Lluís
L
Solà
David
D
Castellnou