[Activity of purine enzyme metabolism in rat thymocytes after irradiation and after administration of riboxine].
It has been established, that the total X-ray irradiation of animals takes influence upon the functional activity of key enzymes of adenine nucleotides metabolism: adenylatekinase, AMP deaminase, 5'-nucleotidase, adenosine deaminase and purine nucleoside phosphorylase in rat's thymocytes. The increase of activity of the investigated enzymes is observed in our experiment, except 5'-nucleotidase, which activity is authentically decreasing after irradiation (1.0 and 7.78 Gy). The injection of the preparation riboxine to experimental animals 15 min prior to the exposure has normalized the purine exchange enzymes activity.
Taras Shevchenko Kyiv National University, Ukraine. kng@mail.univ.kiev.ua
N H
NH
Kudina
T R
TR
Andriĭchuk
B O
BO
Tsudzevych
D015720:5'-Nucleotidase / Q000378:metabolism; D000659:AMP Deaminase / Q000378:metabolism; D000243:Adenosine Deaminase / Q000378:metabolism; D000263:Adenylate Kinase / Q000378:metabolism; D000818:Animals; D004798:Enzymes / Q000187:drug effects* / Q000528:radiation effects*; D007290:Inosine Diphosphate / Q000008:administration & dosage / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D011683:Purine-Nucleoside Phosphorylase / Q000378:metabolism; D011687:Purines / Q000378:metabolism*; D051381:Rats; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D014965:X-Rays
D004798:Enzymes; D011687:Purines; D007290:Inosine Diphosphate; D011683:Purine-Nucleoside Phosphorylase; D000263:Adenylate Kinase; D015720:5'-Nucleotidase; D000243:Adenosine Deaminase; D000659:AMP Deaminase