Anti-oxidative activity of glycosides from Ligustrum sinense.
Three active glycosides that afford protection to red blood cell membrane to resist hemolysis induced by a peroxyl radical initiator, 2,2'-azo-bis-(2-amidinopropane) dihydrochloride (AAPH) were isolated from the MeOH extract of Ligustrum sinense. The compounds are 10-hydroxyl-oleuropein (1), 3-O-alpha-L-rhamnopyranosyl-kaempferol-7-O-beta-D-glucopyranoside (4), and 8'-alpha-hydroxyl-lariciresinol-4'-O-beta-D-glucopyranoside (6). The structures of these glycosides were determined by 1D and 2D NMR spectral analysis.
Ouyang
Ming-An
MA
Department of Chemistry, Huaqiao University, Quanzhou, Fujian 362011, China. maouyang@hqu.edu.cn
He
Zhen-Dan
ZD
Wu
Cui-Ling
CL
D000578:Amidines / Q000009:adverse effects; D000975:Antioxidants / Q000494:pharmacology*; D002462:Cell Membrane; D000081004:Cyclopentane Monoterpenes; D004912:Erythrocytes / Q000502:physiology; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D006139:Guaiacol / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology*; D006461:Hemolysis; D044949:Kaempferols / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D029592:Oleaceae / Q000737:chemistry*; D016877:Oxidants / Q000009:adverse effects
C478860:10-hydroxyoleuropein; C478861:3-O-rhamnopyranosylkaempferol-7-O-glucopyranoside; C478862:8'-hydroxylariciresinol-4'-O-glucopyranoside; D000578:Amidines; D000975:Antioxidants; D000081004:Cyclopentane Monoterpenes; D005960:Glucosides; D044949:Kaempferols; D016877:Oxidants; D006139:Guaiacol; C046728:2,2'-azobis(2-amidinopropane)