Multiple-drug resistance in D-tartrate-positive Salmonella enterica serovar paratyphi B isolates from poultry is mediated by class 2 integrons inserted into the bacterial chromosome.
The presence of integrons in 85 multiresistant German isolates of the predominating Salmonella enterica subsp. enterica serovar Paratyphi B dT(+) clone was investigated. All isolates possessed a chromosomally located Tn7-like class 2 integron carrying the same dfrA1-sat1-aadA1 array of gene cassettes. Only four isolates (4.7%) revealed an additional class 1 integron with two strains each containing the aadA1 or dfrA1-aadA1 gene cassettes.
Miko
Angelika
A
National Salmonella Reference Laboratory, Federal Institute for Risk Assessment, D-12277 Berlin, Germany.
Pries
Karin
K
Schroeter
Andreas
A
Helmuth
Reiner
R
D000818:Animals; D002876:Chromosomes, Bacterial / Q000235:genetics*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D016521:Electrophoresis, Gel, Pulsed-Field; D032023:Integrons / Q000235:genetics*; D010957:Plasmids / Q000235:genetics; D011201:Poultry Diseases / Q000382:microbiology*; D012481:Salmonella Infections, Animal / Q000382:microbiology*; D019779:Salmonella enterica / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism; D012484:Salmonella paratyphi B / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism; D013644:Tartrates / Q000378:metabolism*
D013644:Tartrates; C029768:tartaric acid