Controlled withdrawal of selective serotonin reuptake inhibitor drugs in elderly patients in nursing homes with no indication of depression.
OBJECTIVE
The aim of the investigation was to study the effects of withdrawing selective serotonin reuptake inhibitor (SSRI) drugs in nursing home patients, who had no documented diagnosis or symptoms of depression.


METHODS
The setting of the study was in 11 nursing homes in the county of Stockholm, Sweden.


METHODS
Participants were patients without dementia or history of depression who had received treatment with SSRI drugs for more than 6 months and who had no indications of anxiety disorder or major depression


METHODS
The included patients ( n=70) were randomized to either the intervention group (withdrawal of SSRI) or the control group (no change in treatment), 35 patients to each group.


METHODS
The patients were subjected to assessment using the following instruments: Montgomery-Asberg depression rating scale, global assessment for functioning, health index and a symptom assessment form. Assessment was made at the start of the study and at the 3-month and 6-month follow-ups.


RESULTS
We found no significant difference between the intervention and control groups in any outcome measure.


CONCLUSIONS
Treatment with SSRI drugs in patients without clinical major depression or anxiety disorder is often unjustified and should be discontinued.
Division of Clinical Pharmacology, Stockholm South General Hospital, 11883, Stockholm, Sweden. Johanna.Ulfvarson@sos.sll.se
Johanna
J
Ulfvarson
Johanna
J
Adami
Regina
R
Wredling
Bengt
B
Kjellman
Marie
M
Reilly
Christer
C
von Bahr
D000368:Aged; D000369:Aged, 80 and over; D003866:Depressive Disorder / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D009735:Nursing Homes; D011569:Psychiatric Status Rating Scales; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D013997:Time Factors
D017367:Selective Serotonin Reuptake Inhibitors