Optical coherence tomography for ultrahigh resolution in vivo imaging.
Optical coherence tomography (OCT) is an emerging biomedical optical imaging technique that performs high-resolution, cross-sectional tomographic imaging of microstructure in biological systems. OCT can achieve image resolutions of 1-15 microm, one to two orders of magnitude finer than standard ultrasound. The image penetration depth of OCT is determined by the optical scattering and is up to 2-3 mm in tissue. OCT functions as a type of 'optical biopsy' to provide cross-sectional images of tissue structure on the micron scale. It is a promising imaging technology because it can provide images of tissue in situ and in real time, without the need for excision and processing of specimens.
Fujimoto
James G
JG
Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. jgfuji@mit.edu
D001158:Arteries / Q000473:pathology* / Q000648:ultrastructure; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods*; D019721:Ophthalmoscopes; D009887:Ophthalmoscopy / Q000379:methods*; D012680:Sensitivity and Specificity; D013673:Technology Assessment, Biomedical; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods* / Q000639:trends