Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage.
The DNA base excision repair (BER) is a ubiquitous mechanism for removing damage from the genome induced by spontaneous chemical reaction, reactive oxygen species (ROS) and also DNA damage induced by a variety of environmental genotoxicants. DNA repair is essential for maintaining genomic integrity. As we learn more about BER, a more complex mechanism emerges which supersedes the classical, simple pathway requiring only four enzymatic reactions. The key to understand the complete BER process is to elucidate how multiple proteins interact with one another in a coordinated process under specific physiological conditions.
Izumi
Tadahide
T
Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, TX 77555-1079, USA. taizumi@utmb.edu
Wiederhold
Lee R
LR
Roy
Gargi
G
Roy
Rabindra
R
Jaiswal
Arun
A
Bhakat
Kishor K
KK
Mitra
Sankar
S
Hazra
Tapas K
TK
D000818:Animals; D004249:DNA Damage / Q000235:genetics*; D004260:DNA Repair / Q000235:genetics*; D045643:DNA Repair Enzymes / Q000378:metabolism*; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology
D045643:DNA Repair Enzymes