Distal 10q trisomy associated with bilateral hydronephrosis in infancy.
We present clinical and cytogenetic data on a 2.5 year-old boy with partial monosomy 22p (p11.2-->pter) and distal 10q trisomy (10q24.1-->qter), resulting from maternal t(10;22) reciprocal translocation. The patient had bilateral hydronephrosis and hydroureters but without evidence of vesicoureteral reflux. Our clinical observation suggests that urinary collecting system anomaly may be an integral part of distal 10q trisomy syndrome. We recommend detailed imaging studies of urinary tracts be performed on probands with chromosomal disorders involving a duplication of distal 10q.
Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan, Republic of China. cpc_mmh@yahoo.com
C P
CP
Chen
S P
SP
Lin
D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D020732:Cytogenetic Analysis; D020440:Gene Duplication; D006801:Humans; D006869:Hydronephrosis / Q000235:genetics*; D007223:Infant; D008297:Male; D014178:Translocation, Genetic / Q000235:genetics; D014314:Trisomy / Q000235:genetics*; D014570:Urologic Diseases / Q000235:genetics