Optical resolution of racemic 2-hydroxy octanoic acid by lipase-catalyzed hydrolysis in a biphasic membrane reactor.
Racemic 2-hydroxy octanoic acid methyl ester was optically resolved by lipase-catalyzed hydrolysis in a biphasic membrane reactor using hydrophilic/hydrophobic capillary membranes. In a buffer/hexane biphasic membrane reactor using hydrophilic ultrafiltration membranes, (S)-2-hydroxy octanoic acid was recovered from the aqueous phase at 59-67% yield and 0.9-0.92 enantiomeric excess (ee), and the ester of (R)-isomer was recovered from the organic phase at 73-75% yield and 0.92-0.99 ee.
Sakaki
Keiji
K
National Institute of Advanced Industrial Science and Technology Tsukuba, Ibaraki 305-8565, Japan. k.sakaki@aist.go.jp
Itoh
Naotsugu
N
D019149:Bioreactors; D002210:Caprylates / Q000138:chemical synthesis / Q000737:chemistry* / Q000302:isolation & purification*; D002384:Catalysis; D006868:Hydrolysis; D008049:Lipase / Q000737:chemistry*; D008567:Membranes, Artificial; D013237:Stereoisomerism; D014462:Ultrafiltration / Q000295:instrumentation / Q000379:methods*
D002210:Caprylates; D008567:Membranes, Artificial; D008049:Lipase; C031492:octanoic acid