Abundance of repetitive sequence elements in the mouse testis-specific lactate dehydrogenase-C gene.
We have cloned and sequenced the entire mouse ldhc gene and mapped it physically in relation to the somatic ldha gene. The 2 genes were found to be oriented in head-to-tail fashion with about a 6-kilobase (kb) distance between the 3' end of ldha and the 5' end of ldhc. The ldhc gene is composed of 43% repetitive elements compared to only 16% in the ldha gene. Despite the close physical distance of mouse ldha and ldhc, the 2 genes have a very different content of repetitive elements, and this most likely reflects different levels of selective pressure.
Department of Medical Biosciences, Medical Genetics, Umeå University, Umeå, Sweden.
Per G
PG
Olsson
Hiroshi
H
Tsujioka
Sonoko
S
Narisawa
Erwin
E
Goldberg
José Luis
JL
Millán
D000818:Animals; D001483:Base Sequence / Q000235:genetics; D003001:Cloning, Molecular; D004247:DNA; D007527:Isoenzymes / Q000235:genetics*; D007770:L-Lactate Dehydrogenase / Q000235:genetics*; D008297:Male; D051379:Mice / Q000378:metabolism*; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D013737:Testis / Q000201:enzymology*
D007527:Isoenzymes; D004247:DNA; D007770:L-Lactate Dehydrogenase; C409673:lactate dehydrogenase C4