Comparative immunoprofile of polymorphous low-grade adenocarcinoma and canalicular adenoma.
Immunohistochemistry is an important tool when dealing with salivary gland neoplasms. Canalicular adenoma and polymorphous low-grade adenocarcinoma may share some histologic characteristics that can cause difficulties in their separation. In the present study, cases of polymorphous low-grade adenocarcinoma and canalicular adenoma were submitted to a panel of antibodies to evaluate the differences in their immunoprofiles. The results obtained showed that, while vimentin is only expressed by polymorphous low-grade adenocarcinoma, CK7 and CK8 are present in both neoplasms. Therefore, vimentin is the best marker to differentiate between these tumors.
Furuse
Cristiane
C
Department of Oral Pathology, School of Dentistry, University of São Paulo, Brazil.
Tucci
Renata
R
Machado de Sousa
Suzana O
SO
Rodarte Carvalho
Yasmin
Y
Cavalcanti de Araújo
Vera
V
D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology*; D000236:Adenoma / Q000737:chemistry / Q000473:pathology*; D014408:Biomarkers, Tumor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D053552:Keratin-7; D007633:Keratins / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000737:chemistry / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000737:chemistry / Q000473:pathology; D014746:Vimentin / Q000032:analysis
D014408:Biomarkers, Tumor; C507497:KRT7 protein, human; D053552:Keratin-7; D014746:Vimentin; D007633:Keratins