The effects of frequency in pallidal deep brain stimulation for primary dystonia.
The effect of stimulation frequency for pallidal deep brain stimulation in five patients with either generalized or segmental dystonia was evaluated three to twelve months postoperatively via a randomized, double-blind paradigm. The quality of life and the severity of dystonic symptoms improved by approximately 60% and 43% respectively using a frequency of 130 Hz. Compared with 130 Hz a significant further clinical improvement was observed at frequencies of 180 and 250 Hz, which contrasted with a significant deterioration at lower frequencies (5, 50 Hz) compared to 130 Hz.
Dept. of Neurology, Charité, Campus Virchow, Humboldt University Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. andreas.kupsch@charite.de
A
A
Kupsch
S
S
Klaffke
A A
AA
Kühn
W
W
Meissner
G
G
Arnold
G H
GH
Schneider
K
K
Maier-Hauff
T
T
Trottenberg
D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D004421:Dystonia / Q000473:pathology / Q000628:therapy*; D004599:Electric Stimulation Therapy; D005260:Female; D005917:Globus Pallidus / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D016896:Treatment Outcome