Targeting survival: integration site selection by retroviruses and LTR-retrotransposons.
Replication of retroviruses and retrotransposons depends on selecting a favorable chromosomal site for integration of their genomic DNA. Different retroelements meet this challenge by targeting distinctive chromosomal regions. Despite these differences, recent data hints at a common targeting mechanism-tethering of integration complexes to proteins bound at favorable sites.
Bushman
Frederic D
FD
Infectious Disease Laboratory, The Salk Institute, 10010 North Torrey Pines Rd., La Jolla, CA 92037, USA. bushman@salk.edu
D000818:Animals; D004261:DNA Replication; D004251:DNA Transposable Elements / Q000235:genetics*; D004279:DNA, Viral / Q000235:genetics; D018390:Gene Targeting; D015894:Genome, Human; D006801:Humans; D018626:Retroelements / Q000235:genetics; D012190:Retroviridae / Q000235:genetics*; D020079:Terminal Repeat Sequences; D016662:Virus Integration; D014779:Virus Replication; D015003:Yeasts / Q000235:genetics
D004251:DNA Transposable Elements; D004279:DNA, Viral; D018626:Retroelements