Signal transduction: putting translation before transcription.
A recent microarray-based study shows that Ras/Akt signaling rapidly alters the pattern of existing mRNAs that are recruited to polysomes. This response precedes the effects of transcription on total cellular RNA, suggesting that the primary effect of Ras/Akt signaling on gene expression may occur mainly at the level of translation.
Prendergast
George C
GC
Lankenau Institute for Medical Research, Jefferson Medical School, Thomas Jefferson University, Philadelphia, PA 19107, USA. prendergastg@mlhs.org
D000818:Animals; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D011132:Polyribosomes / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt; D012323:RNA Processing, Post-Transcriptional / Q000502:physiology; D012333:RNA, Messenger / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014158:Transcription, Genetic / Q000502:physiology*; D018631:ras Proteins / Q000378:metabolism
D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; C494918:AKT1 protein, human; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D018631:ras Proteins