Use of cerny epoxides for the accelerated synthesis of glycosaminoglycans.
[reaction: see text]. 1,6:2,3-Dianhydrohexopyranoses (Cerny epoxides) are versatile intermediates for the synthesis of glycosaminoglycans. Complex heparan and chondroitin sulfate disaccharide synthons can be assembled from a single common precursor in a short sequence of steps.
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Sabine
S
Arndt
Linda C
LC
Hsieh-Wilson
D002809:Chondroitin Sulfates / Q000138:chemical synthesis*; D004187:Disaccharides / Q000138:chemical synthesis; D004852:Epoxy Compounds / Q000737:chemistry*; D006025:Glycosaminoglycans / Q000138:chemical synthesis; D006497:Heparan Sulfate / Q000138:chemical synthesis*; D015394:Molecular Structure
D002809:Chondroitin Sulfates; D004187:Disaccharides; D004852:Epoxy Compounds; D006025:Glycosaminoglycans; D006497:Heparan Sulfate