Adult-to-adult living-donor liver transplantation. A summary of current status and an outline of the program in Geneva.
Living donor liver transplantation is a relatively new procedure in which the right side of the liver is harvested in a healthy donor and transplanted into a recipient. After the first case in 1994, over 3000 cases have been done worldwide. This review summarizes the reasons why the procedure is needed, describes its main technical aspects, highlights the boundaries in which it can be done safely, summarizes the current experience worldwide and describes the main points of the program in our unit. We argue that living-donor transplantation is a viable alternative to a long time on the waiting list for several patients, and it can be performed safely and successfully provided that all precautions are undertaken to minimize the risks in the donor and to increase the chances of a good outcome in the recipients. If these prerequisites are met, and within the framework of a structured multidisciplinary program, we believe that living-donor liver transplantation should be funded by health insurances as a recognized therapeutic option.
Transplantation Unit, Department of Surgery, University Hospital, Geneva, Switzerland. pietro.majno@hcuge.ch
P
P
Majno
G
G
Mentha
Th
T
Berney
L H
LH
Bühler
E
E
Giostra
P
P
Gelez
I
I
Morard
M
M
Bednarkiewicz
O
O
Huber
Ph
P
Morel
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000401:mortality / Q000601:surgery*; D005260:Female; D005544:Forecasting; D006301:Health Services Needs and Demand / Q000639:trends; D006498:Hepatectomy / Q000401:mortality / Q000639:trends*; D006801:Humans; D017093:Liver Failure / Q000401:mortality / Q000601:surgery*; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery*; D016031:Liver Transplantation / Q000401:mortality / Q000639:trends*; D019520:Living Donors / Q000600:supply & distribution*; D008297:Male; D008875:Middle Aged; D015996:Survival Rate / Q000639:trends; D013557:Switzerland; D020858:Tissue and Organ Harvesting / Q000401:mortality / Q000639:trends*; D014850:Waiting Lists