Pathogenesis of cholangiocarcinoma in the porta hepatis and infection of hepatitis virus.
OBJECTIVE
To study the correlation between human cholangiocarcinoma in the porta hepatis and the infection of hepatitis virus.


METHODS
Immunohistochemistry was used to detect HBxAg and HCV-C protein in formalin-fixed and paraffin-embedded samples taken from 68 patients with cholangiocarcinoma in the porta hepatis. The findings were reviewed against the clinical records of the patients.


RESULTS
Six patients (8.8%) were positive for HBxAg and 24 (35%) for HCV-C protein, respectively. One patient was positive for both HBxAg and HCV-C protein. There were statistically differences in the extent of differentiation, invasion, lymph-node metastasis, and treatment between the patients with cholangiocarcinomas in the porta hepatis with HB(C)V infection and those without infection.


CONCLUSIONS
HB(C)V infection is correlated to the development of cholangiocarcinoma in the porta hepatis. The tumor with HB(C)V infection may have a higher malignancy biologically and poorer prognosis. HBxAg and HCV-C protein may play an important role in the pathogenesis of cholangiocarcinoma in the porta hepatis.
Department of Hepatobiliary Surgery of Affiliated Yantai Yuhuangding Hospital, Qingdao University Medical College, Yantai 264000, China. liu634@263.net
Xiao-Fang
XF
Liu
Sheng-Quan
SQ
Zou
Fa-Zu
FZ
Qiu
D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000453:epidemiology / Q000821:virology*; D001653:Bile Ducts, Intrahepatic; D015415:Biomarkers; D018281:Cholangiocarcinoma / Q000453:epidemiology / Q000821:virology*; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000453:epidemiology; D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology; D018936:Hepatitis C Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D015534:Trans-Activators / Q000032:analysis; D054334:Viral Regulatory and Accessory Proteins
D015415:Biomarkers; D018936:Hepatitis C Antigens; D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein