Comparison of functional imaging and standard CT in evaluation of disease extent in patients with tumours showing neuroendocrine features.
BACKGROUND
The diagnostic approach that should be used in disseminated neuroendocrine tumours (NET) remains a significant clinical problem. A novel approach has been the use of 111In Octreotide as functional imaging to find NETs. Therefore, the aim of this retrospective study is to report our comparison with direct CT as standard anatomical imaging.


METHODS
A total of 48 patients (aged 16-79 years; mean age 55, SD 14 years) were imaged using both techniques with final histological confirmation of NET. Histology was as follows: 26 carcinoids; 2 pheochromocytomas; 4 gastrinomas, 1 islet tumour; 2 paragangliomas, 1 modullary carcinoma of the thyroid, 8 undetermined NET and 4 other tumours with signs of neuro-ectodermal cancers (2 hepatocellular carcinomas (HCC), fibrolamellar HCC and fibrous tumour). All patients had (111)In Octreotide and 30 had (123)I mIBG scans followed by spiral CT with contrast enhancement. 26 patients had single functional scans and 22 had multiple, up to 6 scans. Extent of disease as number of lesions was compared between CT and octreotide.


RESULTS
CT was the best modality in 11 patients, in 6 it was as good as (111)In Octreotide. mIBG was the best in 6 patients; in 3 patients mIBG was as good as octreotide study. In 22 patients (111)In Octreotide was the most effective modality. In one patient there was no advantage with any of the tests. Comparison of the number of organs involved indicated that an octreotide study was much more effective than CT scanning (Wilcoxon matched pairs test, p < 0.001) and also the overall number of lesions detected using (111)In Octreotide was greater than with CT (Wilcoxon Matched Pairs test p < 0.01).


CONCLUSIONS
Our results confirm the recommendation of the European NET group that functional imaging should be performed in patients with suspected NET.
Department of Nuclear Medicine, Royal Free Hospital, London, UK. buscombe@rfhsm.ac.uk
J B
JB
Cwikła
J R
JR
Buscombe
W A
WA
Mielcarek
M E
ME
Caplin
A J
AJ
Watkinson
A J
AJ
Hilson