Effect of 2,5-dimethylpyrazine on uterine contraction in late stage of pregnant female rats.
Effect of 2,5-dimethylpyrazine (2,5-DMP) on oxytocic agent-induced late pregnant uterine contraction in female rats was studied. Oxytocic agents induced-hypercontraction in the late phase of pregnant uterine movements were inhibited by administration of 2,5-DMP. The inhibition of uterine contraction was obtained more strengthening by presence of a low dose of ritodrine hydrochloride than 2,5-DMP alone. These results suggests that 2,5-DMP has an inhibitory action on uterine hypercontraction induced by oxytocic agent through the beta2-adrenoceptor in the pregnant uterus and supports the applicability of relaxing drugs for oxytocic agent-induced accidents.
Yamada
Kenji
K
School of Pharmacy, Tokyo University of Pharmacy and Life Science, Horinouchi, Hachioji, Tokyo, Japan. kenjiy@ps.toyaku.ac.jp
Sano
Miwa
M
Fujihara
Hisato
H
Ohta
Akihiro
A
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D011247:Pregnancy / Q000187:drug effects* / Q000502:physiology; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014590:Uterine Contraction / Q000187:drug effects* / Q000502:physiology; D014599:Uterus / Q000187:drug effects / Q000502:physiology
D011719:Pyrazines; C075524:2,5-dimethylpyrazine