Antioxidant properties of carvedilol: inhibition of lipid peroxidation, protein oxidation and superoxide generation.
Oxidative stress has been suggested to be an etiological factor in cerebro- and cardiovascular disorders. We examined antioxidant activities of carvedilol, a beta- and alpha-adrenoreceptor blocker. Carvedilol suppressed lipid auto-oxidation and protein carbonyl formation in brain homogenate in a dose-dependent manner. Carvedilol also suppressed superoxide generation of human neutrophils. These properties of carvedilol should be suitable for treating hypertension resulting in cerebro- and cardiovascular diseases.
Department of Neurology, Gunma University School of Medicine, 3-39-22 Showamachi, Maebashi, Gunma 371-8511, Japan.
Yoko
Y
Suzuki
Makoto
M
Tanaka
Makoto
M
Sohmiya
Toshihiko
T
Yoshida
Koichi
K
Okamoto
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002227:Carbazoles / Q000494:pharmacology*; D000077261:Carvedilol; D002417:Cattle; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D011412:Propanolamines / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013481:Superoxides / Q000378:metabolism*; D013552:Swine
D000975:Antioxidants; D002227:Carbazoles; D011412:Propanolamines; D011506:Proteins; D000077261:Carvedilol; D013481:Superoxides