The glial identity of neural stem cells.
Glia are the most numerous cells in the brain, and their many diverse functions highlight their essential role in the nervous system. Recent studies have revealed an unexpected new role for glia in a wide variety of species, that of stem cells/progenitors in the adult and embryonic brain. Differentiation along the glial lineage may be a default state of development reflected in the progression of stem cells along the neuroepithelial-->radial glia-->astrocyte lineage.
Doetsch
Fiona
F
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA. fkd2101@columbia.edu
D000818:Animals; D001253:Astrocytes / Q000166:cytology; D002454:Cell Differentiation / Q000502:physiology*; D019070:Cell Lineage; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology / Q000502:physiology; D004847:Epithelial Cells; D020547:Lateral Ventricles; D009457:Neuroglia / Q000145:classification / Q000166:cytology* / Q000502:physiology; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D013234:Stem Cells / Q000378:metabolism*