Leukemia vaccines.
Evidence that immunological effector mechanisms contribute to the elimination of leukemic blasts in allogeneic bone marrow transplantation supports the concept that the immune system plays a prominent role in the control of leukemic disease. For patients with high-risk acute leukemia, relapse prevention in the setting of minimal residual disease is paramount. This review discusses vaccine strategies aimed to stimulate a leukemia-specific immune response in vivo.
Glouchkova
Ludmila
L
Clinic for Pediatric Oncology, Hematology and Immunology, University Clinic, Heinrich Heine University, Düsseldorf, Germany.
Ackermann
Birgit
B
Dilloo
Dagmar
D
D019496:Cancer Vaccines; D003713:Dendritic Cells / Q000502:physiology; D018014:Gene Transfer Techniques; D006801:Humans; D007938:Leukemia / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy*; D055502:Secondary Prevention
D019496:Cancer Vaccines