Electron microscopy in cell biology: integrating structure and function.
Electron microscopy (EM) is at the highest-resolution limit of a spectrum of complementary morphological techniques. When combined with molecular detection methods, EM is the only technique with sufficient resolution to localize proteins to small membrane subdomains in the context of the cell. Recent procedural and technical developments have increasingly improved the power of EM as a cell-biological tool.
Department of Molecular Cell Biology, Faculty of Biology Institute of Biomembranes, Utrecht, The Netherlands.
Abraham J
AJ
Koster
Judith
J
Klumperman
D000818:Animals; D002468:Cell Physiological Phenomena; D022082:Cellular Structures / Q000502:physiology* / Q000648:ultrastructure*; D006801:Humans; D016253:Microscopy, Immunoelectron / Q000379:methods*