The TRAIL to arthritis.
Antigen-specific lymphocytes are involved in synovial proliferation within inflamed joints. Activated lymphocytes and synoviocytes from patients with rheumatoid arthritis express receptors that can bind TNF-related apoptosis-inducing ligand (TRAIL). A new study demonstrates that DCs pulsed with collagen and transduced with an adenovirus-based vector able to express TRAIL limit the incidence of arthritis in a model of collagen-induced arthritis and joint inflammation. These results suggest that gene-modified cell therapy represents a therapeutic option for systemic rheumatic diseases.
Walter Reed Army Institute of Research, Building 503, Room 1A32, Robert Grand Road, Silver Spring, Maryland 20910, USA. gtsokos@usa.net
George C
GC
Tsokos
Maria
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Tsokos
D000818:Animals; D051017:Apoptosis Regulatory Proteins; D001172:Arthritis, Rheumatoid / Q000628:therapy*; D064987:Cell- and Tissue-Based Therapy; D003094:Collagen / Q000276:immunology*; D003713:Dendritic Cells / Q000502:physiology*; D015316:Genetic Therapy; D008562:Membrane Glycoproteins / Q000235:genetics* / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology; D053221:TNF-Related Apoptosis-Inducing Ligand; D013950:Thymus Gland / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000502:physiology
D051017:Apoptosis Regulatory Proteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011948:Receptors, Antigen, T-Cell; D053221:TNF-Related Apoptosis-Inducing Ligand; C505654:Tnfsf10 protein, mouse; D014409:Tumor Necrosis Factor-alpha; C054979:antigen T cell receptor, zeta chain; D003094:Collagen