The interaction of glycogen synthase kinase-3 (GSK-3) with the cell cycle.
GSK-3 is a multifunctional protein kinase known to play a pivotal role in the regulation of metabolism, the cytoskeleton and gene expression. It also interacts with the cell cycle in a number of ways. GSK-3 forms part of both Wnt and Hh signalling pathways and hence controls expression of a number of cell cycle regulatory genes. Prominent among these is cyclin D1. GSK-3 also phosphorylates cyclin D1 to promote its nuclear export and subsequent degradation. In this chapter we examine how GSK-3 mediates these effects and consider how therapeutic strategies may be developed to specifically target these pathways.
Ryves
W Jonathan
WJ
MRC Laboratory for Molecular Cell Biology, Department of Biology, University College London, Gower St., WC1E 6BT, London, U.K.
Harwood
Adrian J
AJ
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D018816:Genes, cdc / Q000502:physiology*; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D053823:Hedgehog Proteins; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D051176:beta Catenin
C495270:CTNNB1 protein, human; D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; D004791:Enzyme Inhibitors; D053823:Hedgehog Proteins; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D051176:beta Catenin; D019938:Cyclin D1; D038362:Glycogen Synthase Kinase 3