[Expression of main heat stress proteins and p53 in nasopharyngeal carcinoma].
OBJECTIVE
To investigate the expression and the significance of main heat stress proteins (HSPs) and p53 in nasopharyngeal carcinoma.


METHODS
Tissues homogenate and western blot were used to determine the level of HSPs and p53.


RESULTS
HSP27 and p53 elevated remarkably (P < 0.05) while HSP90 and HSP70 showed no significance between nasopharyngeal carcinoma and control tissues. Elevated level of HSP27 and p53 don't correlated with histological type and clinical stage.


CONCLUSIONS
Expression of HSPs and p53 show some difference in nasopharyngeal carcinoma tissue. These data suggest that HSPs and p53 may play a role in the development of nasopharyngeal carcinoma.
Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
Lei
L
Cheng
Lisi
L
Liu
Ming
M
Zhang
Chengfeng
C
Xiao
Tangchun
T
Wu
D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D006360:Heat-Shock Proteins; D016159:Tumor Suppressor Protein p53