Toxicity and antiviral activity of cinnabarin obtained from Pycnoporus sanguineus (Fr.) Murr.
This work describes the cytopathic effect on cells, cytotoxic action on mice, and antiviral activity of cinnabarin. This substance had no effect on mouse neuroblastoma cells (NA cell, ATCC clone C-1300) at a concentration of 0.31 mg/ml, it was not able to cause toxic effects in mice at concentrations of 1000 mg/kg, and reduced by four times the titers of the rabies virus at concentrations of 0.31 mg/ml.
Smânia
A
A
Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Catarina, Florianópolis, Brazil. artursmania@hotmail.com
Marques
C J S
CJ
Smânia
E F A
EF
Zanetti
C R
CR
Carobrez
S G
SG
Tramonte
R
R
Loguercio-Leite
C
C
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009447:Neuroblastoma / Q000188:drug therapy; D010078:Oxazines / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011124:Polyporaceae; D011820:Rabies virus / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D010078:Oxazines; D010936:Plant Extracts; C481268:cinnabarin