In vitro activity of recombinant lysostaphin against Staphylococcus aureus isolates from anterior nares and blood.
The in vitro activity of recombinant lysostaphin was tested against a collection of well-characterized clinical Staphylococcus aureus isolates by disk diffusion (429 isolates) and minimum bactericidal concentration (10 isolates) assays. Minimum bactericidal concentrations of 0.16 microg/ml and zones of inhibition ranging between 15 and 21 mm in diameter demonstrate that lysostaphin was highly active against all isolates tested.
von Eiff
Christof
C
Institute of Medical Microbiology, University of Münster Hospital and Clinics, 48149 Muenster, Germany. eiffc@uni-muenster.de
Kokai-Kun
John F
JF
Becker
Karsten
K
Peters
Georg
G
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology; D002353:Carrier State / Q000382:microbiology; D006801:Humans; D008248:Lysostaphin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009297:Nasal Mucosa / Q000382:microbiology*; D011994:Recombinant Proteins / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000097:blood / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D011994:Recombinant Proteins; D008248:Lysostaphin