Familial aortic aneurysm in Leonberg dogs.
A thoracic aortic aneurysm was diagnosed in a 6-month-old male Leonberg dog by use of radiography, transthoracic and transesophageal echocardiography, and magnetic resonance imaging. The aneurysm was associated with a twisted ascending aorta and dilatation of several other thoracic arteries (pulmonary trunk, brachiocephalic trunk, and left subclavian artery). Histologic examination of the aorta revealed cystic medial necrosis, with disruption of the elastic network, collagen fibers, and the muscle glycoprotein fibrillin-1. The dam and sire of the dog and 8 littermates were examined by use of transthoracic echocardiography. The sire and 1 male littermate also had an aneurysm of the ascending aorta. To the authors' knowledge, this is the first report of familial aortic aneurysm in dogs.
Chetboul
Valérie
V
Unité de Cardiologic d'Alfort, Ecole Nationale Vétérinaire d'Alfort, 94704 Maisons-Alfort Cedex, France.
Tessier
Dominique
D
Borenstein
Nicolas
N
Delisle
Françoise
F
Zilberstein
Luca
L
Payen
Guillaume
G
Leglaive
Eric
E
Franc
Brigitte
B
Derumeaux
Geneviève
G
Pouchelon
Jean-Louis
JL
D000818:Animals; D001011:Aorta / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000473:pathology; D001013:Aorta, Thoracic / Q000473:pathology; D001014:Aortic Aneurysm / Q000175:diagnosis / Q000235:genetics / Q000662:veterinary*; D001947:Breeding; D003937:Diagnosis, Differential; D004285:Dogs; D018618:Echocardiography, Doppler, Color / Q000662:veterinary; D017548:Echocardiography, Transesophageal / Q000662:veterinary; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D013348:Subclavian Artery / Q000002:abnormalities; D013895:Thoracic Arteries / Q000002:abnormalities