Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism.
Class switch recombination is the gene rearrangement process by which our B lymphocytes change from IgM production to IgG, IgA, or IgE. Unlike the well-characterized V(D)J recombination, the mechanism of class switch recombination has been largely enigmatic until very recent progress has begun to shed light on this gene rearrangement process. Progress has been made on the enzymes involved in leading to the DNA cleavage events and on identifying the unusual DNA structures that those enzymes recognize.
Department of Pathology, Norris Comprehensive Cancer Ctr, Rm 5428, 1441 Eastlake Ave, MC9176, Los Angeles, CA 90033, USA.
Kefei
K
Yu
Michael R
MR
Lieber
D000818:Animals; D001402:B-Lymphocytes / Q000201:enzymology / Q000276:immunology; D001483:Base Sequence; D016384:Consensus Sequence; D003564:Cytidine Deaminase / Q000235:genetics; D004247:DNA / Q000737:chemistry; D004798:Enzymes / Q000235:genetics*; D015322:Gene Rearrangement, B-Lymphocyte; D005803:Genes, Immunoglobulin; D006801:Humans; D017578:Immunoglobulin Class Switching; D007134:Immunoglobulin Switch Region; D008969:Molecular Sequence Data; D009696:Nucleic Acids / Q000737:chemistry*; D011995:Recombination, Genetic; D012689:Sequence Homology, Nucleic Acid; D014158:Transcription, Genetic
D004798:Enzymes; D009696:Nucleic Acids; D004247:DNA; D003564:Cytidine Deaminase