A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population.
We have systematically screened the genome for evidence of linkage disequilibrium (LD) with multiple sclerosis (MS) by typing 6000 microsatellite markers in case-control and family based (AFBAC) cohorts from the Italian population. DNA pooling was used to reduce the genotyping effort involved. Four DNA pools were considered: cases (224 Italian MS patients), controls (231 healthy Italians), index (185 index cases from trio families) and parents (the 370 parents of the patient included in the Index pool), respectively. After refining analysis of the most promising 14 markers to emerge from this screening process, only marker D2S367 retained evidence for association.
Dipartimento di Scienze Neurologiche e Psichiatriche, Univ. Bari, Italy.
Maria
M
Liguori
Stephen
S
Sawcer
Efrosini
E
Setakis
Alastair
A
Compston
Mara
M
Giordano
Sandra
S
D'Alfonso
Marta
M
Mellai
Giulia
G
Malferrari
Maria
M
Trojano
Paolo
P
Livrea
Francesca
F
De Robertis
Luca
L
Massacesi
Anna
A
Repice
Clara
C
Ballerini
Tiziana
T
Biagioli
Roberto
R
Bomprezzi
Stefania
S
Cannoni
Giovanni
G
Ristori
Marco
M
Salvetti
Luigi M E
LM
Grimaldi
Ida
I
Biunno
Giancarlo
G
Comi
Maurizio
M
Leone
Isabella
I
Ferro
Paola
P
Naldi
Clara
C
Milanese
Cinzia
C
Gellera
La Mantia
LM
Loredana
Giovanni
G
Savettieri
Giuseppe
G
Salemi
Paolo
P
Aridon
Domenico
D
Caputo
Franca
F
Rosa Guerini
Pasquale
P
Ferrante
Patricia
P
Momigliano-Richiardi
D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods / Q000706:statistics & numerical data; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D007391:International Cooperation; D007558:Italy / Q000453:epidemiology; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D044469:Racial Groups / Q000235:genetics