[Results of international study of quality of life of patients with stable angina treated with nitrates (IQOLAN)].
Effect of transition from multiple administration of short acting nitrates to once daily use of isosorbide-5-mononitrate on angina class and quality of life was studied in 280 patients with stable angina pectoris. Transition to isosorbide-5-mononitrate was associated with increases of (in units) exercise tolerance (Delta=-6.6+/-0.35, p<0.001), satisfaction from treatment (Delta=-2.1+/-0.12, p<0.001), degree of psychological discomfort (Delta=-2.8+/-0.21, p<0.001), decreases of numbers of attacks of angina (Delta=-4.0+/-0.22, p<0.001) and side effects (Delta=-4.1+/-0.29, p<0.001), increase of average distance of walking without chest pain or dyspnea (from 372.1+/-415.1 to 586+/-663.5 m), shortening of duration of episodes of angina (from 4.7+/-4.0 to 4.1+/-7.2 min), significant lowering of angina class (p<0.0001). Thus in patients with ischemic heart disease long acting formulation of isosorbide-5-mononitrate provided rapid onset and stability of therapeutic action what eventually resulted in effective prevention of attacks of angina and improvement of quality of life.
Cardiolgy Research Complex, ul. Tretiya Cherepkovskaya 15a, 121552 Moscow, Russia.
Iu N
IuN
Belenkov
I E
IE
Chazova
L G
LG
Ratova
V V
VV
Dmitriev
N A
NA
Lebedeva
V E
VE
Pavlov
N A
NA
Bishele
S A
SA
Demura
D000787:Angina Pectoris / Q000188:drug therapy* / Q000523:psychology*; D017079:Exercise Tolerance / Q000187:drug effects; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D020030:Nitric Oxide Donors / Q000008:administration & dosage*; D017060:Patient Satisfaction; D011788:Quality of Life; D016896:Treatment Outcome
D020030:Nitric Oxide Donors; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate