Endometriosis arising during estrogen and testosterone treatment 17 years after abdominal hysterectomy: a case report.
OBJECTIVE
To report the possible association between the use of oestrogen replacement therapy and endometriosis in a postmenopausal woman.


METHODS
We present a case of a postmenopausal, previously hysterectomised, woman who received hormonal replacement therapy and developed a large broad ligament cyst. Two years prior to her presentation she had been complaining of pelvic pain and deep dyspareunia.


RESULTS
Pelvic ultrasound showed an adnexal cyst that was increasing in size. CA-125 was normal. Laparoscopy revealed multiple endometriotic deposits and a broad ligament cyst. Cystectomy and oophorectomy were done. Histology confirmed a diagnosis of endometriosis including the broad ligament cyst.


CONCLUSIONS
Hormonal replacement therapy can be associated with de novo endometriosis including at sites, which are unusual.
Minimally Invasive Therapy Unit and Endoscopy Training Centre, University Department of Obstetrics and Gynaecology, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK. amagos@rfc.ucl.ac.uk
Anastasia G
AG
Goumenou
Carl
C
Chow
Alex
A
Taylor
Adam
A
Magos
D000368:Aged; D004715:Endometriosis / Q000139:chemically induced*; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D004967:Estrogens / Q000009:adverse effects* / Q000627:therapeutic use; D005184:Fallopian Tube Diseases / Q000139:chemically induced; D005260:Female; D006801:Humans; D007044:Hysterectomy; D010049:Ovarian Diseases / Q000139:chemically induced; D010532:Peritoneal Diseases / Q000139:chemically induced; D017698:Postmenopause; D013739:Testosterone / Q000009:adverse effects* / Q000627:therapeutic use
D004967:Estrogens; D013739:Testosterone