Non-alcoholic fatty liver disease: the problems we are facing.
OBJECTIVE
To review the current state of research in non-alcoholic fatty liver disease (NAFLD).


METHODS
Searching Medline (1994-2002) and Chinese Medical Journals Index (1998- 2002) for articles on NAFLD.


RESULTS
NAFLD is a new and challenging field with increasing recognition although its pathogenesis is poorly understood. "Two hits" hypothesis is still the leading theory guiding current research.


CONCLUSIONS
Genetic study is a promising way that might lead to breakthrough in NAFLD research. NAFLD study in China is at an initial stage and there is a long way to go.
Department of Gastroenterology, People's Hospital, Beijing University, Beijing 100044, China. jingtongw@yahoo.com.cn
Jing-Tong
JT
Wang
Yu-Lan
YL
Liu
D002681:China / Q000453:epidemiology; D005234:Fatty Liver / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D007333:Insulin Resistance