Secretion defects that activate the phage shock response of Escherichia coli.
The phage shock protein (psp) operon of Escherichia coli is induced by membrane-damaging cues. Earlier studies linked defects in secretion across the inner membrane to induction of the psp response. Here we show that defects in yidC and sec secretion induce psp but that defects in tat and srp have no effect. We have also determined the cellular location of PspB and PspD proteins.
Department of Biological Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom.
Susan E
SE
Jones
Louise J
LJ
Lloyd
Kum K
KK
Tan
Martin
M
Buck
D001426:Bacterial Proteins / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology; D004926:Escherichia coli / Q000378:metabolism / Q000502:physiology*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D006360:Heat-Shock Proteins / Q000378:metabolism*; D018869:Heat-Shock Response; D026901:Membrane Transport Proteins / Q000378:metabolism; D009154:Mutation; D009876:Operon
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D006360:Heat-Shock Proteins; D026901:Membrane Transport Proteins; C412443:YIDC protein, E coli; C069816:phage shock protein, Bacteria