Death receptors.
Death receptors [Fas/Apo-1/CD95, TNF-R1 [tumour necrosis factor (TNF) receptor 1], DR3 [death receptor 3], TRAIL-R1 [TNF-related apoptosis-inducing ligand receptor 1], TRAIL-R2, DR6, p75-NGFR [p75-nerve growth factor receptor], EDAR [ectodermal dysplasia receptor]] form a subgroup of the TNF-R superfamily that can induce apoptosis (programmed cell death) via a conserved cytoplasmic signalling module termed the death domain. Although death receptors have been recognized mainly as apoptosis inducers, there is growing evidence that these receptors also fulfil a variety of nonapoptotic functions. This review is focused on the molecular mechanisms of apoptotic and non-apoptotic death receptor signalling in light of the phenotype of mice deficient in the various death receptors.
Department of Molecular Internal Medicine, Medical Polyclinic, University of Wuerzburg, Roentgenring 11, 97 070 Wuerzburg, Germany. harald.wajant@mail.uni-wuerzburg.de
Harald
H
Wajant
D000818:Animals; D017209:Apoptosis; D053339:Edar Receptor; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism; D053338:Receptors, Ectodysplasin; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D053219:Receptors, Tumor Necrosis Factor, Member 25; D015398:Signal Transduction; D019014:fas Receptor / Q000378:metabolism
C506008:EDAR protein, human; D053339:Edar Receptor; C506009:Edar protein, mouse; D008565:Membrane Proteins; D020800:Receptor, Nerve Growth Factor; D053338:Receptors, Ectodysplasin; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D018124:Receptors, Tumor Necrosis Factor; D053219:Receptors, Tumor Necrosis Factor, Member 25; C105190:TNFRSF10A protein, human; C505639:TNFRSF10B protein, human; C506033:TNFRSF25 protein, human; C505640:Tnfrsf10b protein, mouse; C485251:Tnfrsf21 protein, mouse; C506034:Tnfrsf25 protein, mouse; D019014:fas Receptor