Synthesis of dimethyl sulfomycinamate.
[reaction: see text] Dimethyl sulfomycinamate, the oxazole-thiazole-pyridine product generated in the methanolysis of the thiopeptide antibiotic sulfomycin I, is prepared in 13 steps and 8% overall yield by the Bohlmann-Rahtz heteroannulation of 1-(oxazol-4-yl)enamines and methyl 4-(trimethylsilyl)-2-oxobut-3-ynoate.
Department of Chemistry, Cardiff University, P.O. Box 912, Cardiff, CF10 3TB, United Kingdom.
Mark C
MC
Bagley
James W
JW
Dale
Xin
X
Xiong
Justin
J
Bower