Sorting it out: AP-2 and alternate clathrin adaptors in endocytic cargo selection.
The AP-2 adaptor complex is widely viewed as a linchpin molecule in clathrin-mediated endocytosis, simultaneously binding both clathrin and receptors. This dual interaction couples cargo capture with clathrin coat assembly, but it has now been discovered that the association with cargo is tightly regulated. Remarkably, AP-2 is not obligatory for all clathrin-mediated uptake, and several alternate adaptors appear to perform similar sorting and assembly functions at the clathrin bud site.
Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. traub@pitt.edu
Linton M
LM
Traub
D033962:Adaptor Protein Complex 2 / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002966:Clathrin / Q000378:metabolism*; D022163:Clathrin-Coated Vesicles / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D011485:Protein Binding; D021381:Protein Transport / Q000502:physiology*; D015398:Signal Transduction
D033962:Adaptor Protein Complex 2; D002966:Clathrin