The nuclear pore complex: nucleocytoplasmic transport and beyond.
Over the past two years, it has become evident that there is an unexpected link between nuclear pore complex structure and dynamics, nucleocytoplasmic transport and chromosome segregation. In addition, a tomographic three-dimensional reconstruction of native nuclear pore complexes preserved in thick amorphous ice has unveiled a number of new structural features of this supramolecular machine. These data, together with some of the elementary physical principles that underlie nucleocytoplasmic transport, will be discussed in this review.
Maurice E. Müller Institute for Structural Biology, Biozentrum, University of Basel, Switzerland. birthe.fahrenkrog@unibas.ch
Birthe
B
Fahrenkrog
Ueli
U
Aebi
D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D000818:Animals; D008954:Models, Biological; D008958:Models, Molecular; D022022:Nuclear Pore / Q000378:metabolism* / Q000648:ultrastructure; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism; D020931:ran GTP-Binding Protein / Q000378:metabolism
D028861:Nuclear Pore Complex Proteins; D020931:ran GTP-Binding Protein