[Plasmin-alpha 2-antiplasmin complexes in blood of patient with lichen planus against the background of other fibrinolysis parameters].
The aim of the present study was to evaluate fibrinolysis in patients with lichen planus. In blood of 20 patients (12 women, 8 men) the levels of tissue type plasminogen activator (t-PA), plasmin-antiplasmin complexes (PAP) and D-dimer were examined. The control group consisted of 37 healthy volunteers. The concentrations of t-PA, PAP and D-dimer were higher in patients with lichen planus in comparison with the control group. It seems that increased level of t-PA antigen in the blood of the patients with lichen planus was the effect of t-PA releasing from endothelial cells. The results of the present study suggest that increased concentrations of t-PA antigen, PAP and D-dimer were the evidence of higher activity of fibrinolysis system in subjects with lichen planus.
Katedra i Klinika Dermatologii Akademii Medycznej w Bydgoszczy.
Anna
A
Wankiewicz
Iza
I
Iwan-Zietek
Maria
M
Kotschy
Agata
A
Zwolska
D000328:Adult; D000368:Aged; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005341:Fibrinolysin / Q000378:metabolism*; D006801:Humans; D008010:Lichen Planus / Q000097:blood*; D008297:Male; D008875:Middle Aged; D000979:alpha-2-Antiplasmin / Q000378:metabolism*
D005338:Fibrin Fibrinogen Degradation Products; D000979:alpha-2-Antiplasmin; C036309:fibrin fragment D; C037742:plasmin-plasmin inhibitor complex; D005341:Fibrinolysin