Growth hormone molecular heterogeneity and exercise.
There are more than 100 molecular isoforms of circulating growth hormone (GH), but the traditional measurement approach in the exercise literature has only focused on the main isoform (i.e., 22 kDa). New assay methodologies now can assess various GH isoforms. The current data suggest that exercise results in the preferential release of GH isoforms with extended half-lives, thereby sustaining biological actions.
Military Performance Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760, USA. Bradley.nindl@na.amedd.army.mil
Bradley C
BC
Nindl
William J
WJ
Kraemer
James O
JO
Marx
Alexander P
AP
Tuckow
Wesley C
WC
Hymer
D015444:Exercise / Q000502:physiology*; D014644:Genetic Variation / Q000502:physiology*; D019382:Human Growth Hormone / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007118:Immunoassay / Q000379:methods; D020033:Protein Isoforms / Q000378:metabolism
D020033:Protein Isoforms; D019382:Human Growth Hormone