3-alkoxy-5-isoxazolidinones mimic beta-lactams.
3-Alkoxy-5-isoxazolidinones mimic the action of beta-lactams. They bind to the penicillin-binding proteins. They inhibit Class A, Class B, and Class D beta-lactams. They inhibit the growth of Bacillus subtilis. We give a novel synthesis for these compounds.
Cao
Xuefei
X
Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, USA.
Iqbal
Amjad
A
Patel
Amit
A
Gretz
Paul
P
Huang
Gregory
G
Crowder
Michael
M
Day
Richard A
RA
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001412:Bacillus subtilis / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development*; D001426:Bacterial Proteins / Q000737:chemistry*; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D032701:Biomimetics / Q000379:methods; D002352:Carrier Proteins / Q000737:chemistry*; D002455:Cell Division / Q000187:drug effects; D006602:Hexosyltransferases / Q000737:chemistry*; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D002267:Muramoylpentapeptide Carboxypeptidase / Q000737:chemistry*; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases / Q000737:chemistry*; D011485:Protein Binding; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams / Q000737:chemistry* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002352:Carrier Proteins; D007555:Isoxazoles; D046915:Penicillin-Binding Proteins; D065093:beta-Lactamase Inhibitors; D047090:beta-Lactams; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D002267:Muramoylpentapeptide Carboxypeptidase