Evaluation of the film-forming property of hydrogenated rosin.
The film-forming and coating properties of a new biomaterial, hydrogenated rosin (HR), is investigated in the present communication. Films produced by casting method are studied for mechanical, (tensile strength, elongation, and Young's modulus), water vapor transmission, and moisture absorption characteristics. Type of plasticizer and its concentration were observed to play an important role in modifying the film characteristics. Dibutyl sebacate (DBS), a hydrophobic plasticizer, was found to be suitable for development of flexible and smooth films. Film formulations plasticized with DBS were investigated for coating the drug layered nonpareil seeds where plasticization facilitated development of smooth and uniformly coated pellets. The increase in coat buildup, however, did not sustain the drug release significantly. The studies conclude that HR films promise utility as moisture-protective hydrophobic, film-coating materials.
Department of Pharmaceutical Sciences, Nagpur University, Nagpur, India.
P M
PM
Satturwar
S V
SV
Fulzele
S B
SB
Joshi
A K
AK
Dorle
D000042:Absorption; D003998:Dicarboxylic Acids / Q000737:chemistry; D004008:Diclofenac / Q000737:chemistry; D005990:Glycerol / Q000737:chemistry; D010968:Plasticizers / Q000737:chemistry; D012116:Resins, Plant / Q000737:chemistry*; D012995:Solubility; D013718:Tensile Strength
D003998:Dicarboxylic Acids; D010968:Plasticizers; D012116:Resins, Plant; D004008:Diclofenac; C055481:dibutyl sebacate; C013893:rosin; D005990:Glycerol