Immunoscintigraphy of septic loosening of knee endoprosthesis: a retrospective evaluation of the antigranulocyte antibody BW 250/183.
Immunoscintigraphy with the use of the antigranulocyte antibody BW 250/183 is a reliable method for detecting infection, especially in septic loosening of hip prostheses, for which purpose quantitative interpretation of the time-activity course is employed. Therefore, we retrospectively studied whether similar results could be achieved in knee prostheses. We verified 28 scintigraphic examinations in 26 patients by histology. Scintigraphy was performed during an early (4-6 h post injection) and a late phase (23-25 h post injection). Infection was diagnosed when activity around the knee prosthesis increased by more than 10% compared with bone marrow. We found a sensitivity and a negative predictive value of 100%, a specificity of 80%, a positive predictive value of 81% and an accuracy of 89%. Specificity and accuracy are lower than in the evaluation of hip prostheses; however, in comparison to other scintigraphic modalities, scintigraphy with the antigranulocyte antibody BW 250/183 is superior in excluding infection and has better specificity and accuracy. Therefore, as in the case of hip prostheses, the described methodology appears to be the scintigraphic modality of choice for knee prostheses.
Clinic of Nuclear Medicine, University Hospital Giessen, Friedrichstrasse 25, 35385, Giessen, Germany. rigobert.klett@radiol.med.uni-giessen.de
Rigobert
R
Klett
Jens
J
Kordelle
Ulrich
U
Stahl
Alexander
A
Khalisi
Maximillian
M
Puille
Dagmar
D
Steiner
Richard
R
Bauer
D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D005260:Female; D006098:Granulocytes / Q000000981:diagnostic imaging*; D006801:Humans; D007593:Joint Instability / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D007719:Knee Joint / Q000000981:diagnostic imaging* / Q000473:pathology; D007720:Knee Prosthesis / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011475:Prosthesis Failure; D016459:Prosthesis-Related Infections / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D016719:Radioimmunodetection / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology
D000911:Antibodies, Monoclonal; C104213:BW 250 183; D019275:Radiopharmaceuticals