Thrombophilia does not increase risk for neonatal complications in preterm infants.
The association between thrombophilia and neonatal complications was evaluated in a single-center prospective study. Prevalence of genetic prothrombotic markers (FVL, MTHFR, FIIG20210A) and levels of plasma homocysteine were assayed in 166 premature (mean gestational age: 30.9+/-2.3 weeks) and low birth weight (mean weight: 1327+/-319 grams) infants. The incidence of any neonatal complications was compared in infants with and without thrombophilia. A total of 38 infants were defined as "thrombophilic" due to heterozygous FVL (n=4) and/or FIIG20210A (n=8, including one case of combination with FVL) or homozygous 677T MTHFR (n=22) or homocysteine plasma levels above 15 micro mole/liter. Neonatal complications included: small for gestational age (28.8%), respiratory distress syndrome (51.8%), broncho-pulmonary dysplasia (10.2%), patent ductus arteriosus (12.7%), intraventricular hemorrhage (17%), periventricular leucomalacia (8.4%), retinopathy of prematurity (15.1%) and necrotizing enterocolitis in 1.2% of infants. No thrombosis was documented. The prevalence of perinatal complications and the severity of diseases were similar among infants with or without thrombophilia (p = 0.564). Our data suggest that preterm infants with thrombophilia are not at increased risk for developing neonatal complications.
Kenet
Gili
G
The Pediatric Coagulation Service, Institute of Thrombosis and Hemostasis, Sackler School of Medicine, Tel-Aviv University, Israel.
Maayan-Metzger
Ayala
A
Rosenberg
Nurit
N
Sela
Ben-Ami
BA
Mazkereth
Ram
R
Ifrah
Aviyah
A
Kuint
Jacob
J
D016022:Case-Control Studies; D004198:Disease Susceptibility; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D007235:Infant, Premature, Diseases / Q000097:blood / Q000209:etiology*; D015995:Prevalence; D011446:Prospective Studies; D012306:Risk; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis