Efficient and general protocol for the copper-free sonogashira coupling of aryl bromides at room temperature.
[reaction: see text]. A mild and general protocol for the copper-free Sonogashira coupling of aryl bromides with acetylenes has been developed. The use of (AllylPdCl)2 and P(t-Bu)3 provides the active Pd(0) catalyst that allows subsequent coupling of various alkynes at room temperature with good to excellent yields.
Department of Process Research, Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, USA. arash_soheili@merck.com
Arash
A
Soheili
Jennifer
J
Albaneze-Walker
Jerry A
JA
Murry
Peter G
PG
Dormer
David L
DL
Hughes