Diagnostic instruments for dementia in older people with intellectual disability in clinical practice.
There is a need for simple and reliable screening instruments for dementia in the intellectual disability (ID) population that can also be used to follow their progress, particularly if they are being treated with anti-dementia drugs. Commonly used tests for the general population such as the Mini Mental State Examination (MMSE) are not appropriate for many people with ID. This paper is a literature review of alternative instruments that have been used in research or recommended by experts since 1991 and have the potential to be used as screening instruments. Two types of tests have been identified: those administered to informants, and those that rely on direct assessment of the individual. The most promising informant rated screening tool in most adults with ID including Down syndrome (DS) diagnosis is the Dementia Questionnaire for Persons with Mental Retardation (DMR). However, sensitivity in single assessments is variable and cut-off scores need further optimisation. In those with DS, the Dementia Scale for Down Syndrome (DSDS) has good specificity but mediocre sensitivity. The Test for Severe Impairment and Severe Impairment Battery are two direct assessment tools that show promise as screening instruments, but need further evaluation.
Strydom
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Department of Psychiatry and Behavioral Sciences, University College London, London, UK. a.strydom@ucl.ac.uk
Hassiotis
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D003072:Cognition Disorders / Q000175:diagnosis*; D003704:Dementia / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D008607:Intellectual Disability / Q000150:complications*; D009483:Neuropsychological Tests; D010818:Practice Patterns, Physicians'; D012680:Sensitivity and Specificity