Controlled release of vitamin E from thermo-responsive polymeric physico-gel.
Thermo-sensitive copolymer consists of poly(2-ethoxyethyl vinyl ether) and poly(hydroxyethyl vinyl ether) (EOVE200-HOVE400), whose sol-gel transition temperature was 20.5 degrees C, was synthesized and its applicability to a drug delivery system was examined. Vitamin E (VE) was enclosed in EOVE200-HOVE400 and the release of VE was measured by varying the temperature 10<-->30 degrees C. There was no release of VE from EOVE200-HOVE400 at 30 degrees C, while VE was released when the temperature was reduced to 10 degrees C.
Ishida
Masato
M
Faculty of Science and Technology, Tokyo Universtiy of Science, Yamazaki, Noda, Chiba, Japan.
Sakai
Hideki
H
Sugihara
Shinji
S
Aoshima
Sadahito
S
Yokoyama
Shoko
S
Abe
Masahiko
M
D016503:Drug Delivery Systems; D004987:Ethers / Q000737:chemistry; D005079:Excipients; D005782:Gels; D006358:Hot Temperature; D007202:Indicators and Reagents; D008970:Molecular Weight; D014753:Vinyl Compounds / Q000737:chemistry; D014810:Vitamin E / Q000008:administration & dosage* / Q000737:chemistry
D004987:Ethers; D005079:Excipients; D005782:Gels; D007202:Indicators and Reagents; D014753:Vinyl Compounds; C487325:poly(2-ethoxyethyl vinyl ether); C487324:poly(hydroxyethyl vinyl ether); D014810:Vitamin E