The role of protein elongation factor eEF1A2 in ovarian cancer.
Frequent gains of chromosome 20q12-13 in ovarian tumors indicate that at least one important oncogene is found at that locus. One of the genes there is EEF1A2, which maps to 20q13.3 and encodes protein elongation factor eEF1A2. This review will focus on recent evidence indicating that EEF1A2 is an important ovarian oncogene and that the protein elongation network can activate tumorigenesis and inhibit apoptosis.
Lee
Jonathan M
JM
Hamilton Regional Cancer Centre, 699 Concession Street, Hamilton, Ontario, Canada L8V 5C2. jonathan.lee@hrcc.on.ca
D017209:Apoptosis / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002869:Chromosome Aberrations; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics / Q000648:ultrastructure; D005260:Female; D005784:Gene Amplification; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D010051:Ovarian Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D010441:Peptide Chain Elongation, Translational; D020648:Peptide Elongation Factor 1 / Q000235:genetics / Q000502:physiology*; D014314:Trisomy
C503234:EEF1A2 protein, human; D020648:Peptide Elongation Factor 1