Stable lanthanide luminescence agents highly emissive in aqueous solution: multidentate 2-hydroxyisophthalamide complexes of Sm(3+), Eu(3+), Tb(3+), Dy(3+).
Efficient lanthanide (Ln) luminescent probes require good ligand-to-metal energy transfer and high aqueous stability. A family of ligands based on 2-hydroxyisophthalamide chelating units is reported. These form highly stable, eight-coordinate Ln complexes. Several of these (Ln = Sm, Eu, Tb, Dy) emit in the visible region with good ligand-to-lanthanide energy transfer. The absolute quantum yields of the two Tb complexes studies (Phi = 0.59, 0.61) and high absorbance make these the brightest luminescent probes for time-resolved detection; the emission spectrum of one complex can be seen down to 10-15 M. The low overlap of the four different Ln complexes enables their simultaneous detection and discrimination.
Department of Chemistry, University of California, Berkeley, California 94720-1460, USA.
Stéphane
S
Petoud
Seth M
SM
Cohen
Jean-Claude G
JC
Bünzli
Kenneth N
KN
Raymond
D002614:Chelating Agents / Q000737:chemistry; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008163:Luminescent Measurements; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry*; D012996:Solutions; D014867:Water / Q000737:chemistry
D002614:Chelating Agents; D028581:Lanthanoid Series Elements; D009942:Organometallic Compounds; D012996:Solutions; D014867:Water