Increasing Latino adolescents' adherence to treatment for latent tuberculosis infection: a controlled trial.
OBJECTIVE
We sought to determine the efficacy of coaching Latino adolescents with latent tuberculosis infection to adhere to isoniazid treatment.


METHODS
Participants (n = 286) were randomly assigned to adherence coaching, attention control, or usual care groups. Adherence was measured via interviews and validated with urine assays.


RESULTS
Coaching resulted in significant increases in adherence compared with attention and usual care groups. Bicultural adolescents were more likely to be adherent than those most or least acculturated. Age and risk behavior were negatively related to adherence.


CONCLUSIONS
Coaching can increase Latino adolescents' adherence to treatment for latent tuberculosis infection and should contribute to tuberculosis control for adolescents at high risk of contracting the disease.
Center for Behavioral Epidemiology and Community Health, Graduate School of Public Health, San Diego State University, CA 92123, USA.
Melbourne F
MF
Hovell
Carol L
CL
Sipan
Elaine J
EJ
Blumberg
C Richard
CR
Hofstetter
Donald
D
Slymen
Lawrence
L
Friedman
Kathleen
K
Moser
Norma J
NJ
Kelley
Alicia Y
AY
Vera
D000293:Adolescent; D000294:Adolescent Behavior / Q000208:ethnology*; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000652:urine; D002140:California; D003376:Counseling; D005260:Female; D006302:Health Services Research; D006630:Hispanic or Latino / Q000523:psychology*; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage* / Q000652:urine; D008297:Male; D008800:Mexico / Q000208:ethnology; D010349:Patient Compliance / Q000208:ethnology*; D011292:Premedication / Q000523:psychology; D012646:Self Administration / Q000523:psychology; D012649:Self Concept; D012944:Social Support; D014376:Tuberculosis / Q000188:drug therapy / Q000517:prevention & control*
D000995:Antitubercular Agents; D007538:Isoniazid