Lymphangioleiomyomatosis: a case-control study of perinatal and early life events.
BACKGROUND
Lymphangioleiomyomatosis (LAM), a rare disease affecting women, is caused by somatic mutations in the tuberous sclerosis complex genes.


METHODS
A case-control questionnaire study was carried out examining parental and family history, prenatal events, and early life events to try to shed light on the aetiology of the condition. Forty five patients identified from a national LAM register completed a questionnaire and 31 were compared with 117 age and sex matched control subjects using conditional logistic regression.


RESULTS
No differences were found in perinatal events, childhood infections, and parental or family history, except that patients were more likely to be an only child (odds ratio (OR) 4.3 (95% confidence interval (CI), 1.5 to 11.8)) and have a relative with uterine fibroids (OR 4.2 (1.4 to 13)). Patients with LAM had had fewer pregnancies and fewer children but no differences in miscarriage rates. A non-matched analysis using all 45 cases and 117 controls gave similar results.


CONCLUSIONS
No features in the family history, perinatal events, or early life events were detected that were associated with having LAM. Being more likely to be an only child and having an increased family history of uterine fibroids may, if confirmed, indicate some differences in reproductive function within the families of affected individuals.
Whale
C I
CI
Division of Respiratory Medicine, City Hospital, Nottingham, UK.
Johnson
S R
SR
Phillips
K G
KG
Newton
S A
SA
Lewis
S A
SA
Tattersfield
A E
AE
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004739:England / Q000453:epidemiology; D005192:Family Health; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008016:Life Change Events; D018192:Lymphangioleiomyomatosis / Q000453:epidemiology / Q000209:etiology*; D008875:Middle Aged; D010375:Pedigree; D012044:Regression Analysis; D012307:Risk Factors; D011795:Surveys and Questionnaires