Effects of autogenic training and antihypertensive agents on circadian and circaseptan variation of blood pressure.
Even when the daily blood pressure mean is acceptable, too large a circadian amplitude of blood pressure largely increases cardiovascular disease risk. Autogenic training (N = 11), a non-pharmacologic intervention capable of lowering an excessive blood pressure variability, may be well-suited for MESOR-normotensive patients diagnosed with circadian-hyper-amplitude-tension (CHAT). Not all anti-hypertensive drugs affect blood pressure variability. Accordingly, long-acting carteolol (N = 11) and/or atenolol (N = 8) may be preferred to captopril retard (N = 13), nilvadipine (N = 8), or amlodipine (N = 7) for midline-estimating statistic of rhythm (MESOR)-hypertensive patients with CHAT. Prospective outcome studies are needed to assess whether the relative merits of these treatments are in keeping with their effects on blood pressure and blood pressure variability.
Tokyo Women's Medical University, Tokyo, Japan. yoshi-w@jd5.so-net.ne.jp
Yoshihiko
Y
Watanabe
Germaine
G
Cornélissen
Misako
M
Watanabe
Fumihiko
F
Watanabe
Kuniaki
K
Otsuka
Shi-ichiro
S
Ohkawa
Takenori
T
Kikuchi
Franz
F
Halberg
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001326:Autogenic Training; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000628:therapy*; D010507:Periodicity
D000959:Antihypertensive Agents