Mechanisms of TfR-mediated transcytosis and sorting in epithelial cells and applications toward drug delivery.
Transferrin receptor has been an important protein for many of the advances made in understanding the intricacies of the intramolecular sorting pathways of endocytosed molecules. The unique internalization and recycling functions of transferrin receptor have also made it an attractive choice for drug targeting and delivery of large protein-based therapeutics and toxins. Recent advances in elucidating the role of the intracellular controllers of transferrin recycling and sorting, such as Rab proteins and their effectors, have led to enhancement of transferrin receptor as a drug delivery vehicle. This review focuses on the use of transferrin receptor as an agent for facilitating drug delivery and targeting, and the role that mechanisms of transferrin receptor sorting and transcytosis play in these events.
Widera
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A
Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, PSC 404B, 1985 Zonal Avenue, Los Angeles, CA 90033, USA.
Norouziyan
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F
Shen
W-C
WC
D000818:Animals; D001692:Biological Transport; D016503:Drug Delivery Systems; D004705:Endocytosis / Q000502:physiology*; D004847:Epithelial Cells / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010599:Pharmacokinetics; D011990:Receptors, Transferrin / Q000378:metabolism* / Q000502:physiology; D014168:Transferrin / Q000378:metabolism
D004364:Pharmaceutical Preparations; D011990:Receptors, Transferrin; D014168:Transferrin