Standardization of an inactivated H17N1 avian influenza vaccine and efficacy against A/Chicken/Italy/13474/99 high-pathogenicity virus infection.
The minimum requirements for assessing the immunogenicity of an experimental avian influenza (AI) vaccine prepared from inactivated A/Turkey/Italy/2676/99 (H7N1) low-pathogenicity (LP) AI (LPAI) virus were determined in chickens of different ages. A correlation between the amount of hemagglutinin (HA) per dose of vaccine and the protection against clinical signs of disease and infection by A/Chicken/Italy/13474/99 highly pathogenic (HP) AI (HPAI) virus was established. Depending on the vaccination schedule, one or two administrations of 0.5 microg of hemagglutinin protected chickens against clinical signs and death and completely prevented virus shedding from birds challenged at different times after vaccination.
Istituto Superiore di Sanità, V. le Regina Elena 299, 00156, Roma, Italy.
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Di Trani
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Cordioli
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Falcone
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Lombardi
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Moreno
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Sala
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Tollis
D000818:Animals; D000917:Antibody Formation; D002645:Chickens / Q000276:immunology / Q000821:virology; D004305:Dose-Response Relationship, Drug; D007115:Immunization Schedule; D009980:Influenza A virus / Q000145:classification / Q000276:immunology* / Q000472:pathogenicity*; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000592:standards*; D005585:Influenza in Birds / Q000276:immunology*; D007279:Injections, Subcutaneous; D007558:Italy; D011201:Poultry Diseases / Q000276:immunology / Q000821:virology; D011786:Quality Control; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000592:standards*
D007252:Influenza Vaccines; D015164:Vaccines, Inactivated