Protein phosphatase 2A as a new target for morphogenetic studies in the chick limb.
The family of ser/thr protein phosphatases 2A (PP2A) is a major regulator of cell proliferation and cell death and is critically involved in the maintenance of homeostasis. In order to analyse the importance of PP2A proteins in apoptotic and developmental processes, this review focuses on previous studies concerning the role of PP2A in morphogenesis. We first analyse wing formation in Drosophila, a model for invertebrates, then chick limb bud, a model for vertebrates. We also present a pioneer experiment to illustrate the potential relevance of PP2A studies in BMP signalling during chicken development and we finally discuss the BMP downstream signalling pathways.
Faculté de Médecine, LEDAC UMR 5538 Institut Albert Bonniot, Rond Point de la Chantourne, 38706 La Tronche cedex, France
Jean
J
Viallet
Alphonse
A
Garcia
André
A
Weydert
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism*; D002642:Chick Embryo; D004330:Drosophila / Q000196:embryology; D004625:Embryo, Nonmammalian; D018878:Limb Buds / Q000201:enzymology*; D009024:Morphogenesis / Q000502:physiology*; D010749:Phosphoprotein Phosphatases / Q000502:physiology*; D054648:Protein Phosphatase 2; D015398:Signal Transduction; D014921:Wings, Animal / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development
D019485:Bone Morphogenetic Proteins; D010749:Phosphoprotein Phosphatases; D054648:Protein Phosphatase 2