Risk of congenital anomalies near the Byker waste combustion plant.
BACKGROUND
The aim of this study was to determine whether the risk of congenital anomalies in a population resident close to a waste combustion plant located at Byker in the city of Newcastle upon Tyne, United Kingdom, was higher than in a population resident further away.


METHODS
A geographical study was carried out on the prevalence of congenital anomalies in residents living within 3 km (inner zone) of the Byker combustion plant compared with those living 3-7 km (outer zone) from the plant. There were 81255 live births (1985-1999) and 1508 cases with chromosomal and non-chromosomal congenital anomalies. The cases were identified from the Northern Region Congenital Abnormality Survey.


RESULTS
After the site commenced operation the estimated rate ratio (inner versus outer zone) was 1.11 (95 per cent confidence interval (CI) 0.96-1.28) adjusted for socio-economic deprivation. There was significant heterogeneity across years and an increasing trend, of marginal significance (p = 0.07), in the rate ratio. The inner zone rate approached or became significantly higher than that in the outer zone in some of the later years.


CONCLUSIONS
No significant overall association between the number of congenital anomalies and proximity of residence to the Byker waste combustion plant has been found in this study. Significantly increased rates near the site during the later years may suggest a possible risk but are difficult to interpret. More comprehensive, multi-site investigations around other waste combustion plants are indicated.
Cresswell
P A
PA
Northern Yorkshire and Public Health Observatory, Wolfson Research Institute, University of Durham Stockton Campus, Stockton-on-Tees TS17 6BH. tricia.cresswell@durhamclspct.nhs.uk
Scott
J E S
JE
Pattenden
S
S
Vrijheid
M
M
D000393:Air Pollutants / Q000009:adverse effects*; D016009:Chi-Square Distribution; D000013:Congenital Abnormalities / Q000453:epidemiology* / Q000209:etiology*; D004739:England / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D015995:Prevalence; D012037:Refuse Disposal; D018570:Risk Assessment; D012307:Risk Factors
D000393:Air Pollutants