Condensin and biological role of chromosome condensation.
Mitotic chromosome condensation is an essential cellular function ensuring proper compaction and segregation of sister chromatids during cell division. Condensin, a five-subunit complex, conserved among eukaryotes, is the key molecular machine of chromosome condensation. Recent advances in the structural biology and functional analysis of condensin demonstrate the unique nature and indispensable biological role of this complex. Condensin functions span chromosome dynamics during mitotic cell division, cell-cycle feedback control mechanisms, as well as formation and maintenance of interphase chromosome structure. Being at the intersection of several cell-cycle regulatory networks condensin is a promising therapeutic target for control over cell proliferation.
Strunnikov
Alexander V
AV
NIH, National Institute of Child Health and Human Development, Laboratory of Gene Regulation and Development, 18T Library Drive, Room 106, Bethesda, Maryland 20892, USA.
D000251:Adenosine Triphosphatases / Q000235:genetics*; D000818:Animals; D018797:Cell Cycle Proteins / Q000187:drug effects / Q000235:genetics; D002455:Cell Division / Q000187:drug effects / Q000235:genetics*; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D020090:Chromosome Segregation / Q000187:drug effects / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D046912:Multiprotein Complexes; D021122:Protein Subunits / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics
D018797:Cell Cycle Proteins; D002843:Chromatin; D004268:DNA-Binding Proteins; D046912:Multiprotein Complexes; D021122:Protein Subunits; C108312:condensin complexes; D000251:Adenosine Triphosphatases