Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients.
We report the first two genome-wide screens for linkage disequilibrium between putative multiple sclerosis (MS) susceptibility genes and genetic markers performed in the genetically homogenous Scandinavian population, using 6000 microsatellite markers and DNA pools of approximately 200 MS cases and 200 controls in each screen. Usable data were achieved from the same 3331 markers in both screens. Nine markers from eight genomic regions (1p33, 3q13, 6p21, 6q14, 7p22, 9p21, 9q21 and Xq22) were identified as potentially associated with MS in both screens.
Institute of Immunology, Rikshospitalet University Hospital, 0027 Oslo, Norway. h.f.harbo@labmed.uio.no
Hanne F
HF
Harbo
Pameli
P
Datta
Annette
A
Oturai
Lars P
LP
Ryder
Stephen
S
Sawcer
Efrosini
E
Setakis
Eva
E
Akesson
Elisabeth G
EG
Celius
Helena
H
Modin
Magnhild
M
Sandberg-Wollheim
Kjell-Morten
KM
Myhr
Oluf
O
Andersen
Jan
J
Hillert
Per Soelberg
PS
Sorensen
Arne
A
Svejgaard
Alastair
A
Compston
Frode
F
Vartdal
Anne
A
Spurkland
D000483:Alleles; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods* / Q000706:statistics & numerical data; D015894:Genome, Human; D005838:Genotype; D006650:Histocompatibility Testing; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology