Novel approaches to identifying antiarrhythmic drugs.
Currently, device therapy with implantable cardioverter-defibrillators is the only proven effective therapy for sudden cardiac death. However, new insights into the mechanisms of ventricular fibrillation, particularly the role of dynamic factors that cause wave instability, are providing conceptual advances toward developing effective new pharmacotherapy.
Departments of Medicine (Cardiology) and Physiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1760, USA. jweiss@mednet.ucla.edu
James N
JN
Weiss
Alan
A
Garfinkel
Peng-Sheng
PS
Chen
D000200:Action Potentials / Q000187:drug effects; D000889:Anti-Arrhythmia Agents / Q000191:economics / Q000627:therapeutic use*; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D016757:Death, Sudden, Cardiac / Q000517:prevention & control; D006801:Humans; D014693:Ventricular Fibrillation / Q000188:drug therapy* / Q000517:prevention & control
D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers