Arylnaphthalide lignans from Cleistanthus collinus.
Chemical examination of the aerial parts of Cleistanthus collinus afforded the arylanphthalide lignans, cleistanone (1), diphyllin (2), cleistanthins A (3), C (4) and D (5), and 4-O-(3"-O-methyl-beta-D-glucopyranosyl)-diphyllin (6). The first compound is a new member of the rare group of arylnaphthalide lignans containing an alkoxy group on the lactone ring. The structure of the compound was determined from its spectral data, chemical transformations and partial synthesis from diphyllin (2). The new lignan, 1 and its acetyl derivative, 7 were found to exhibit cytotoxicity against MT(2) cell lines.
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabal, India. biswanathdas@yahoo.com
Chimmani
C
Ramesh
Nasi
N
Ravindranath
Tejomoortula Siva
TS
Ram
Biswanath
B
Das
D000107:Acetylation; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D052117:Benzodioxoles; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D004148:Dioxolanes / Q000737:chemistry; D019665:Euphorbiaceae / Q000737:chemistry*; D006801:Humans; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
D000972:Antineoplastic Agents, Phytogenic; D052117:Benzodioxoles; D004148:Dioxolanes; D017705:Lignans; C487301:cleistanone; C010130:diphyllin