Occlusive vasculitis in a patient with concomitant West Nile virus infection.
OBJECTIVE
To describe a patient with occlusive, retinal vasculitis and concomitant, confirmed, acute West Nile virus (WNV) infection.


METHODS
Observational case report.


METHODS
Main outcome measures included comprehensive ophthalmic examination with fluorescein angiography, color photography, and serologic testing for WNV and St. Louis encephalitis (SLE) virus including plaque reduction neutralization testing (PRNT).


RESULTS
A 46-year-old woman developed a sudden decrease in vision in her left eye 2 weeks after confirmed WNV infection and demonstrated multiple, small, patchy areas of retinal edema with scattered microaneurysms. Fluorescein angiography showed multiple branch artery occlusions with extensive nonperfusion. Serologic titers for WNV were positive for acute infection. Plaque reduction neutralization testing confirmed WNV infection and excluded St. Louis encephalitis virus infection. Other etiologies of occlusive vasculitis were not present.


CONCLUSIONS
Occlusive, retinal vasculitis may occur in the setting of acute WNV infection.
Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Peter K
PK
Kaiser
Michael S
MS
Lee
Denise A
DA
Martin
D000208:Acute Disease; D000914:Antibodies, Viral / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008875:Middle Aged; D015356:Retinal Artery Occlusion / Q000175:diagnosis / Q000209:etiology*; D031300:Retinal Vasculitis / Q000175:diagnosis / Q000209:etiology*; D014792:Visual Acuity; D014901:West Nile Fever / Q000150:complications* / Q000175:diagnosis; D014902:West Nile virus / Q000276:immunology / Q000302:isolation & purification*
D000914:Antibodies, Viral; D007075:Immunoglobulin M