A patient with epilepsia partialis continua with anti-glutamate receptor epsilon 2 antibodies.
This report concerns a 6-year-old female with epilepsia partialis continua. Autoantibodies against amino- and carboxyl-terminal regions of the N-methyl-D-aspartate receptor subunit glutamate receptor epsilon 2 were detected in the serum and cerebrospinal fluid. The anti-glutamate receptor epsilon 2 subunit antibodies have been demonstrated in the serum and cerebrospinal fluid in some patients with chronic progressive epilepsia partialis continua of childhood and those with Rasmussen's encephalitis. The patient, however, did not develop any neurologic deterioration or intractable seizures. Therefore, anti-glutamate receptor epsilon 2 subunit antibodies are not specific for chronic progressive epilepsia partialis continua of childhood and Rasmussen's encephalitis.
Kumakura
Akira
A
Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Shiga, Japan.
Miyajima
Tomoko
T
Fujii
Tatsuya
T
Takahashi
Yukitoshi
Y
Ito
Masatoshi
M
D001323:Autoantibodies / Q000097:blood* / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D002648:Child; D017036:Epilepsia Partialis Continua / Q000276:immunology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*
D001323:Autoantibodies; D015415:Biomarkers; C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate