Interventional therapy of malignant obstructive jaundice.
OBJECTIVE
To assess the short-term results of interventional therapy for malignant obstructive jaundice.


METHODS
In 82 patients with malignant obstructive jaundice, hepatocellular carcinoma was detected in 10 patients, carcinoma of gallbladder in 14, hilar biliary carcinoma in 22, pancreatic carcinoma in 20, and hilar metastatic carcinoma in 16. Percutaneous transhepatic biliary internal and/or external drainage (PTBIED) was performed in 61 patients and percutaneous transhepatic insertion of biliary stent (PTIBS) in 21.


RESULTS
The level of total serum bilirubin (TSB) was reduced in 71 patients and less markedly in others. The level of TSB of the 61 patients was reduced from 450.12+/-113.51 micromol/L before operation to 240.25+/-107.81 micromol/L and 90.91+/-101.72 micromol/L 1 and 2 weeks after operation respectively. The TSB level of the 21 patients was reduced from 410.53+/-98.13 micromol/L to 270.23+/-115.64 micromol/L and 105.43+/-97.85 micromol/L 1 and 2 weeks after operation, respectively. No significant difference was found in the effect between PTBIED and PTIBS. Short-term complications developed in 33 patients. Seven patients died 30 days after operation.


CONCLUSIONS
Interventional therapy may be simple, safe and effective in the treatment of malignant obstructive jaundice.
Department of General Surgery, First People's Hospital, 261 Huansha Road, Hangzhou 310006, China. caiyang68@hotmail.com
Guang-Hua
GH
Feng
Yang
Y
Cai
Zhong
Z
Jia
De-Qi
DQ
Yang
Hu
H
Chen
Hui-Cheng
HC
Jin
Qiang-Hong
QH
Yu
Wei
W
Zhu
Chu-Xiong
CX
Wang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000150:complications*; D002779:Cholestasis / Q000209:etiology / Q000601:surgery; D004322:Drainage; D005260:Female; D005706:Gallbladder Neoplasms / Q000150:complications; D006801:Humans; D041781:Jaundice, Obstructive / Q000209:etiology* / Q000601:surgery*; D008113:Liver Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications / Q000556:secondary; D011300:Preoperative Care; D015607:Stents
D000900:Anti-Bacterial Agents