Inconsistent use of diabetes medications, diabetes complications, and mortality in older mexican americans over a 7-year period: data from the Hispanic established population for the epidemiologic study of the elderly.
OBJECTIVE
The aim of this study was to examine the relationship between inconsistency in use of diabetes drugs and risk of renal, eye, and circulation problems and death over a 7-year period in community-dwelling older Mexican Americans.


METHODS
Data are from the four waves of the Hispanic Established Population for the Epidemiologic Study of the Elderly. In-home interviewers assessed consistency in use of diabetes medications among 908 diabetic Mexican Americans, aged >or=65 years. Diabetes and complications were by self-report. Subjects with poor consistency in use of medication were those who, at any time during the 7-year follow-up, discontinued or inconsistently used their diabetes medications and those who had no diabetic medications at home despite self-report of taking medicine for diabetes.


RESULTS
Thirty-six percent of our sample were inconsistent with diabetes medication usage. Older age and lack of supplemental health insurance were significantly associated with inconsistency of use of medication. In a multivariate logistic regression model, subjects with poor consistency in use of medication were more likely to report kidney problems (odds ratio [OR] 1.59; 95% CI 1.13-2.23; P = 0.008) at follow-up compared with those with good consistency, after controlling for age, sex, medication type, duration of diabetes, education, income, marital status, language of interview, insurance status, cognitive function, presence of depressive symptoms, activities of daily living, and instrumental activities of daily living. In Cox regression models, poor consistency with diabetic medication was also associated with increased all-cause mortality (hazard ratio [HR] 1.43; 95% CI 1.13-1.82; P = 0.003) and diabetes-related deaths (1.66; 1.20-2.30; P = 0.002) over a 7-year period after adjusting for relevant confounders.


CONCLUSIONS
Inconsistent use of diabetic medication was associated with an increased risk of kidney problems and deaths over a 7-year period in older Mexican Americans.
Center on Aging, University of Texas Medical Branch, Galveston, Texas 77555-0460, USA. yokuo@utmb.edu
Yong-Fang
YF
Kuo
Mukaila A
MA
Raji
Kyriakos S
KS
Markides
Laura A
LA
Ray
David V
DV
Espino
James S
JS
Goodwin
D000368:Aged; D003071:Cognition; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy* / Q000208:ethnology / Q000401:mortality*; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy* / Q000208:ethnology / Q000401:mortality*; D003925:Diabetic Angiopathies / Q000208:ethnology / Q000401:mortality; D003928:Diabetic Nephropathies / Q000208:ethnology / Q000401:mortality; D003930:Diabetic Retinopathy / Q000208:ethnology / Q000401:mortality; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D017058:Mexican Americans / Q000706:statistics & numerical data*; D010349:Patient Compliance; D015995:Prevalence; D012646:Self Administration
D007004:Hypoglycemic Agents; D007328:Insulin