Fluconazole resistance rate of Candida species from different regions and hospital types in Taiwan.
From April 15 to June 15, 1999, 581 clinical Candida isolates from 19 hospitals in Taiwan were collected and susceptibilities to fluconazole of these isolates were determined by a broth microdilution method. A total of 42 (7.2%) isolates were resistant to fluconazole. Isolates from medical centers had a higher resistance rate to fluconazole than those from regional hospitals (10.7% vs 4.9%). Candida species isolated from different regions had different degrees of susceptibility to fluconazole. Approximately 2.5%, 6.5%, and 11.8% of Candida isolates from middle, north, and south regions, respectively, were resistant to fluconazole. The prevalence of the combination of Candida glabrata, Candida krusei, and Candida tropicalis infections were 44.5%, 49.8%, and 62.7% in middle, north, and south regions, respectively. There is an association between the rate of fluconazole resistance and the number of non-albicans Candida species collected from different regions and hospital types.
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan, ROC.
Yun-Liang
YL
Yang
Hsiao-Hsu
HH
Cheng
Yong-An
YA
Ho
Chin-Fu
CF
Hsiao
Hsiu-Jung
HJ
Lo
D000046:Academic Medical Centers; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification; D041221:Candida glabrata / Q000187:drug effects / Q000302:isolation & purification; D041022:Candida tropicalis / Q000187:drug effects / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology*; D006764:Hospitals, Community; D006784:Hospitals, Teaching; D006801:Humans; D013624:Taiwan
D000935:Antifungal Agents; D015725:Fluconazole