Synthesis and relative binding affinity to human steroid receptors of substituted 3-aryloxycoumarins.
The synthesis of a set of substituted 3-aryloxycoumarins was performed. The study of the relations between their structure and their relative binding affinity to human androgen, progesterone, alpha and beta estrogen receptors was achieved.
Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie de PARIS-SUD, 5 rue Jean-Baptiste Clément, F-92296 Cedex, Chatenay Malabry, France.
Robert
R
Bakhchinian
François
F
Terrier
Serge
S
Kirkiacharian
Michèle
M
Resche-Rigon
Françoise
F
Bouchoux
Evelyne
E
Cérède
D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D003374:Coumarins / Q000138:chemical synthesis* / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding / Q000502:physiology; D011987:Receptors, Steroid / Q000378:metabolism*
D003374:Coumarins; D011987:Receptors, Steroid