Synthesis, characterization and biological properties of a novel copper complex.
The study of copper complex in relation to cancer is important in many ways. A novel copper complex has been synthesized with non toxic ligand, viz. potassium salt of N-(2-hydroxy acetophenone) glycinate (NHAG). The structure of the complex has been determined by spectroscopic means. Toxicity and antitumor property of the complex has been studied in vivo. Though the complex is toxic at higher doses, lower non toxic doses of the complex deplete glutathione (GSH). GSH depleting property of the complex may be utilized to sensitize drug resistant cells where resistance is due to elevated level of GSH.
Department of Environmental Carcinogenesis and Toxicology (ECT), Chittaranjan National Cancer Institute (CNCI), 37 S.P. Mukherjee Road, Calcutta 700 026, India.
Surajit
S
Majumder
Gouri Sankar
GS
Panda
Soumitra
S
Kumar Choudhuri
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D001772:Blood Cell Count; D001854:Bone Marrow Cells / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D002470:Cell Survival / Q000187:drug effects; D003300:Copper; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D019008:Drug Resistance, Neoplasm; D005978:Glutathione / Q000378:metabolism; D008024:Ligands; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000627:therapeutic use* / Q000633:toxicity; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D015996:Survival Rate
D000970:Antineoplastic Agents; D008024:Ligands; D009942:Organometallic Compounds; D003300:Copper; D005978:Glutathione