Serum brain-derived neurotrophic factor (BDNF) levels in schizophrenia are indistinguishable from controls.
Our previous study showed that serum brain-derived neurotrophic factor (BDNF) was significantly decreased in the antidepressant-naive patients with major depressive disorders. However, it was still unclear whether serum BDNF level was altered in drug-naive patients with schizophrenia. Using ELISA, we measured serum BDNF levels in antipsychotic-naive (n=15) and medicated (n=25) patients with schizophrenia, and in age- and sex-matched normal controls (n=40). There were no significant differences in serum BDNF levels among antipsychotic-naive (n=15) and medicated (n=25) patients and normal controls (n=40). Possible factors such as duration of illness, age of onset, Brief Psychiatric Rating Scale scores, and chlorpromazine equivalent dosages of antipsychotics did not reveal any significant correlations with BDNF levels. Our results do not support the view that serum BDNF levels are associated with schizophrenia.
Department of Psychiatry, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuou-ku, Chiba 260-8670, Japan. eiji@faculty.chiba-u.jp
Eiji
E
Shimizu
Kenji
K
Hashimoto
Hiroyuki
H
Watanabe
Naoya
N
Komatsu
Naoe
N
Okamura
Kaori
K
Koike
Naoyuki
N
Shinoda
Michiko
M
Nakazato
Chikara
C
Kumakiri
Sin-ichi
S
Okada
Masaomi
M
Iyo
D000328:Adult; D017668:Age of Onset; D000368:Aged; D014150:Antipsychotic Agents / Q000494:pharmacology; D001921:Brain / Q000254:growth & development / Q000378:metabolism* / Q000503:physiopathology*; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood* / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000378:metabolism; D012559:Schizophrenia / Q000097:blood* / Q000503:physiopathology
D014150:Antipsychotic Agents; D019208:Brain-Derived Neurotrophic Factor; D004298:Dopamine