Melanoma-associated leukoderma.
A case is presented of a man with a history of melanoma treated with sentinel lymphadenectomy and interferon therapy, who subsequently developed diffuse hypopigmented patches thought to be consistent with a diagnosis of melanoma-associated leukoderma. Clinically, melanoma-associated leukoderma is a diffuse macular hypomelanosis or depigmentation, which often develops at sites distant to the location of the primary melanoma. The leukoderma may be hypomelanotic and mottled or depigmented and milk-white. Spontaneous repigmentation may occur. A recent study has demonstrated that T cells involved in the destruction of neoplastic melanocytes are identical clones of those that accumulate in melanoma-associated leukoderma.
Ronald O. Perelman Department of Dermatology, New York University, USA.
Elizabeth K
EK
Hale
Jody W
JW
Konstadt
D006801:Humans; D017496:Hypopigmentation / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology