The ameliorating effects of cognition-enhancing Chinese herbs on scopolamine- and MK-801-induced amnesia in rats.
The study was to investigate the ameliorating effects of three Chinese herbs--Achyranthes bidentata (AB), Ophiopogon japonicus (OJ) and Cnidium monnieri (CM) on scopolamine (SCOP)- and MK-801-induced amnesia by using a passive avoidance task in rats. AB, OJ and CM at 0.1 and 0.3 g/kg prolonged the step-through latency (STL) of the retention trial. In addition, AB, OJ and CM reversed the STL shortened by MK-801, but only AB reversed the STL shortened by SCOP. In conclusion, these Chinese herbs possess cognition-enhancing activities and anti-amnestic effects, but the mechanism of the effect of AB was different from those of OJ and CM.
Institute of Chinese Pharmaceutical Sciences, China Medical College Taichung, Taiwan, ROC.
Ying-Chih
YC
Lin
Chi-Rei
CR
Wu
Chun-Ju
CJ
Lin
Ming-Tsuen
MT
Hsieh
D029044:Achyranthes; D000647:Amnesia / Q000139:chemically induced / Q000517:prevention & control*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D031048:Cnidium; D016291:Dizocilpine Maleate; D008297:Male; D018727:Muscarinic Antagonists / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D031441:Ophiopogon; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D012601:Scopolamine
D018727:Muscarinic Antagonists; D010936:Plant Extracts; D016291:Dizocilpine Maleate; D012601:Scopolamine