Design of experiment (DOE) methods maximize information from a minimal number of animals in special cases of preclinical bioavailability testing.
Kuentz
Martin
M
F.Hoffmann-La Roche Ltd., Pharma, PRNF, Basel, Switzerland. martin.kuentz@roche.com
Röthlisberger
Dieter
D
Richter
Wolfgang
W
D000818:Animals; D000830:Animals, Laboratory; D001682:Biological Availability; D035843:Biomedical Research / Q000379:methods*; D004285:Dogs; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005260:Female; D008252:Macaca fascicularis; D008433:Mathematics; D012107:Research Design