[The role of skeletal muscle in the regulation of glucose homeostasis].
Muscle tissue has been considered to be a major regulator of systemic glucose homeostasis. Glucose normally provides energy sources for tissues of the body. Its uptake by muscle requires a secretion of insulin. The initial step of glucose utilization requires the transport of glucose into the cells. The insulin-receptor complex stimulates the cellular uptake of glucose. In the well-fed state muscle contains about 1% of its weight as glycogen. Because of its mass, muscle contains almost four times as much glycogen as the liver. Muscle glycogen is not directly available as a source of blood glucose because muscle lacks glucose-6-phosphatase. During muscular activity, glycogen is converted to lactate and then into blood glucose in the liver.
Górnoślaskie Centrum Zdrowia Dziecka i Matki, Poradnia Diabetologiczna w Katowicach, Katowice, Poland. em.buczkowski@pro.onet.pl
Ewa
E
Otto Buczkowska
Tomasz
T
Dworzecki
D001692:Biological Transport; D005947:Glucose / Q000378:metabolism* / Q000493:pharmacokinetics; D006003:Glycogen / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D018482:Muscle, Skeletal / Q000378:metabolism*
D007328:Insulin; D006003:Glycogen; D005947:Glucose