Palladium-catalyzed intermolecular coupling of aryl chlorides and sulfonamides under microwave irradiation.
[reaction: see text] An efficient intermolecular N-arylation of sulfonamides with aryl chlorides is realized using palladium catalysis. The reaction proceeds under microwave irradiation at 180-200 degrees C for 10 min with 2-10 mol % of Pd catalyst in 32-85% isolated yields.
GlaxoSmithKline, Discovery Research, High-throughput Chemistry, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA.
George
G
Burton
Ping
P
Cao
Gang
G
Li
Ralph
R
Rivero