Management and outcome of tuberculosis patients who fail treatment under routine programme conditions in Malawi.
METHODS
All 43 non-private hospitals (three central, 22 district and 18 mission) in Malawi that registered and treated TB cases between 1 July 1999 and 30 June 2000.


OBJECTIVE
To determine 1) the number of new smear-positive PTB patients who failed treatment, 2) the management of patients who failed, 3) their treatment outcome and 4) culture and drug sensitivity results.


METHODS
Retrospective data collection using TB registers and laboratory culture and drug sensitivity registers.


RESULTS
Ninety patients failed treatment, 60 (67%) at 5 months and 30 (33%) at the end of treatment. Sixty-four (71%) failure patients were registered and commenced on anti-tuberculosis treatment. Of these, 95% were registered in the same hospital as before, 89% were given a different TB registration number, 67% were correctly registered as 'failures' and 61% were treated within one month of failing the previous regimen. Forty-eight (75%) re-treated patients were cured. Only 31 (34%) of the 90 patients had sputum sent for culture and drug sensitivity testing. In 11 patients with cultures of M. tuberculosis, eight were fully sensitive and three had mono-resistance to isoniazid.


CONCLUSIONS
While the outcome of failure patients who start retreatment is good, there are several programmatic deficiencies that need to be corrected.
Community Health Science Unit, National Tuberculosis Control Programme, Lilongwe, Malawi. adharries@malawi.net
A D
AD
Harries
T E
TE
Nyirenda
J R
JR
Kemp
B S
BS
Squire
P
P
Godfrey-Faussett
F M L
FM
Salaniponi
D000995:Antitubercular Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D007538:Isoniazid / Q000494:pharmacology / Q000627:therapeutic use*; D008295:Malawi; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019233:Retreatment; D012189:Retrospective Studies; D013183:Sputum / Q000382:microbiology; D017211:Treatment Failure; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
D000995:Antitubercular Agents; D007538:Isoniazid