Regulation of AMPA receptor activity, synaptic targeting and recycling: role in synaptic plasticity.
The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors for the neurotransmitter glutamate are oligomeric structures responsible for most fast excitatory responses in the central nervous system. The activity of AMPA receptors can be directly regulated by protein phosphorylation, which may also affect the interaction with intracellular proteins and, consequently, their recycling and localization to defined postsynaptic sites. This review focuses on recent advances in understanding the dynamic regulation of AMPA receptors, on a short- and long-term basis, and its implications in synaptic plasticity.
Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.
André R
AR
Gomes
Susana S
SS
Correia
Ana Luísa
AL
Carvalho
Carlos B
CB
Duarte
D000818:Animals; D004705:Endocytosis; D009473:Neuronal Plasticity / Q000502:physiology*; D010766:Phosphorylation; D021381:Protein Transport; D018091:Receptors, AMPA / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology; D013569:Synapses / Q000502:physiology*
D018091:Receptors, AMPA; D018094:Receptors, Metabotropic Glutamate