Rivastigmine in subcortical vascular dementia: a randomized, controlled, open 12-month study in 208 patients.
Subcortical vascular dementia (VaD) is characterized by executive dysfunction and behavioral problems, reflecting deterioration of the frontal lobe. This study aimed to determine whether rivastigmine, a dual inhibitor of acetylcholinesterase (AChE) and butyryl-cholinesterase (BuChE), has any effects on the typical symptoms of subcortical VaD. Patients receiving rivastigmine showed a slight improvement in executive functions and in behavior. Side effects in both groups were tolerable and there were no study withdrawals. Moreover, there are no drug interactions with other therapies previously and concomitantly assumed. Improvements in domains that characterize subcortical VaD were observed, indicating that rivastigmine may have provided targeted treatment in areas of the brain that are particularly affected in this patient population.
Dipartimento di Fisiologia e Patologia, Dipartimento di Medicina Clinica e Neurologia, Ambulatorio Disturbi Cognitivi, Università degli Studi di Trieste, Trieste, Italy.
Rita
R
Moretti
Paola
P
Torre
Rodolfo M
RM
Antonello
Giuseppe
G
Cazzato
Antonio
A
Bava
D000110:Acetylcholinesterase / Q000378:metabolism; D000368:Aged; D000369:Aged, 80 and over; D002091:Butyrylcholinesterase / Q000378:metabolism; D002219:Carbamates / Q000494:pharmacology* / Q000627:therapeutic use*; D003072:Cognition Disorders / Q000175:diagnosis; D015140:Dementia, Vascular / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D009483:Neuropsychological Tests; D048448:Phenylcarbamates; D000068836:Rivastigmine; D012720:Severity of Illness Index
D002219:Carbamates; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D048448:Phenylcarbamates; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D000068836:Rivastigmine