Percutaneous mitral valve repair: a feasibility study in an ovine model of acute ischemic mitral regurgitation.
Annuloplasty is the cornerstone of surgical mitral valve repair. A percutaneous transvenous catheter-based approach for mitral valve repair was tested by placing a novel annuloplasty device in the coronary sinus of sheep with acute ischemic mitral regurgitation. Mitral regurgitation was reduced from 3-4+ to 0-1+ in all animals (P < 0.03). The annuloplasty functioned by reducing septal-lateral mitral annular diameter (30 +/- 2.1 mm preinsertion vs. 24 +/- 1.7 mm postinsertion; P < 0.03). These preliminary experiments demonstrate that percutaneous mitral annuloplasty is feasible. Further study is necessary to demonstrate long-term safety and efficacy of this novel approach.
Division of Cardiac Surgery, Beth-Israel Deaconess Medical Center, Boston, Massachusetts, USA.
John R
JR
Liddicoat
Briain D
BD
Mac Neill
A Marc
AM
Gillinov
William E
WE
Cohn
Chi-Hui
CH
Chin
Aldo D
AD
Prado
Natesa G
NG
Pandian
Stephen N
SN
Oesterle
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D020878:Device Removal; D004195:Disease Models, Animal; D004452:Echocardiography; D004562:Electrocardiography; D005240:Feasibility Studies; D006339:Heart Rate / Q000502:physiology; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000601:surgery; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D008955:Models, Cardiovascular; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D012756:Sheep; D013318:Stroke Volume / Q000502:physiology