Multiple eruptive dermatofibromas with CD34+ cells in a patient with hypertriglyceridemia.
Multiple eruptive dermatofibromas (MEDF) are rare and have been thought to be associated with altered immunity. It has been reported that dermatofibromas (DFs) are positive for factor X IIIa but not for CD34. In this report, we describe a 34-year-old Japanese woman with MEDF and persistent hypertriglyceridemia. Histopathological examination revealed that several areas in larger nodules, showing higher cellularity and storiform growth pattern, had CD34+ cells. Our case and the review of previous reports suggest that hyperlipidemia, including hypertriglyceridemia, could induce MEDF and that highly cellular areas in DFs are sometimes positive for CD34.
Tsunemi
Yuichiro
Y
Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan. ytsun-tky@umin.ac.jp
Ihn
Hironobu
H
Hattori
Naoko
N
Saeki
Hidehisa
H
Tamaki
Kunihiko
K
D000328:Adult; D018952:Antigens, CD34 / Q000276:immunology; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D018219:Histiocytoma, Benign Fibrous / Q000150:complications / Q000276:immunology / Q000473:pathology*; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D007150:Immunohistochemistry; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000150:complications / Q000276:immunology / Q000473:pathology*
D018952:Antigens, CD34