Mitosis: long-range signals guide microtubules.
The formation of microtubule-derived structures is thought to involve nucleation in all directions and stabilization of microtubules that contact relevant targets. A recent study indicates, during mitosis, there may be a third step, in which microtubule growth is directed over long distances without physical contact between the target and microtubules.
Stukenberg
P Todd
PT
Department of Biochemistry and Molecular Genetics, University of Virginia Medical School, Charlottesville, Virginia 22908, USA. pts7h@virginia.edu
D008870:Microtubules / Q000378:metabolism*; D008938:Mitosis / Q000502:physiology*; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000502:physiology*