Increased density of human immunodeficiency virus type 1 coreceptors CCR5 and CXCR4 on the surfaces of CD4(+) T cells and monocytes of patients with Schistosoma mansoni infection.
Distribution of chemokine receptors CCR5 and CXCR4, which are also coreceptors for human immunodeficiency virus type 1 invasion of cells, was measured on the surfaces of CD4(+) T cells and monocytes in peripheral blood samples from a group of Kenyan car washers. Patients with active schistosomiasis displayed higher cell surface densities of these receptors than did cured schistosomiasis patients.
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30341, USA. was4@cdc.gov
W Evan
WE
Secor
Amil
A
Shah
Pauline M N
PM
Mwinzi
Bryson A
BA
Ndenga
Caroline O
CO
Watta
Diana M S
DM
Karanja
D000163:Acquired Immunodeficiency Syndrome / Q000209:etiology*; D015496:CD4-Positive T-Lymphocytes / Q000737:chemistry*; D015497:HIV-1; D006801:Humans; D019713:Receptors, CCR5 / Q000032:analysis*; D019718:Receptors, CXCR4 / Q000032:analysis*; D012555:Schistosomiasis mansoni / Q000276:immunology*
D019713:Receptors, CCR5; D019718:Receptors, CXCR4