Genetic factors underlying prostate cancer.
Prostate cancer is one of the leading causes of cancer-related death in the USA. In the past decade, tremendous progress has been made in the identification and understanding of the genetic factors related to prostate cancer development. Unlike many other types of cancers, only a small fraction of prostate cancer cases are aggressive and life-threatening. The factors related to prostate cancer development and progression appear complex and diverse. This review summarises some of the important findings in the areas of genome and gene expression abnormalities in prostate cancer, and aims to provide a comprehensive view of new developments in these areas.
Luo
Jian-Hua
JH
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. luoj@msx.upmc.edu
Yu
Yan Ping
YP
D002869:Chromosome Aberrations; D015972:Gene Expression Regulation, Neoplastic; D052138:Genes, Neoplasm; D006801:Humans; D008297:Male; D009154:Mutation; D011471:Prostatic Neoplasms / Q000235:genetics*