A method for heart rate-corrected estimation of baroreflex sensitivity.
OBJECTIVE
The relationship between the prevailing heart rate (HR) and the baroreflex sensitivity (BRS) is described in the present study together with a method for individual HR-corrected estimations of BRS.


METHODS
HR and BRS, determined with the sequence method, were measured in ten young healthy subjects during rest, stress, standing and bicycle exercise, i.e. at a wide range of HRs.


RESULTS
BRS decreased exponentially with increasing HR. The relationship between the natural logarithm of BRS and HR was linear in each individual and could be described by the equation of a straight line. The equation describing the individual BRS-HR relationship could be derived either from BRS and HR measured during steady-state conditions or from the slope and average HR of the individual sequences occurring throughout the experimental protocol. The latter method was preferable since it did not require recordings during steady-state conditions. In order to eliminate the influence of differences in HR on BRS when comparing BRS between subjects, the equation describing the individual BRS-HR relationship was used to calculate BRS at a HR of 60 bpm, BRS(60), which ranged from 9.5 to 30.1 ms/mmHg for the 10 subjects.


CONCLUSIONS
Considering the dramatic effect of a small difference in HR on BRS, especially at lower HRs, BRS should be estimated at a wide range of HRs in order to determine the HR-corrected BRS from the individual HR-BRS relationship. Otherwise, comparisons of BRS between different individuals, study groups or following drug treatment or other interventions would be highly dependent on differences in HR and thereby easily misinterpreted.
Experimental Medicine and Integrative Pharmacology, AstraZeneca R and D Mölndal, Mölndal, Sweden. christina.abrahamsson@astrazeneca.com
Christina
C
Abrahamsson
Catherine
C
Ahlund
Margareta
M
Nordlander
Lars
L
Lind
D000328:Adult; D017704:Baroreflex; D002309:Cardiology / Q000379:methods; D005080:Exercise Test; D005260:Female; D006339:Heart Rate; D006706:Homeostasis; D006801:Humans; D008297:Male; D011187:Posture / Q000502:physiology; D012044:Regression Analysis; D012146:Rest; D013312:Stress, Physiological / Q000503:physiopathology