Frictional properties of poly(MPC-co-BMA) phospholipid polymer for catheter applications.
A fundamental understanding of surface properties of the biomaterials at a nanometer scale should be generated in order to understand cellular responses of the tissue to biomaterials thereby minimizing or eliminating tissue trauma at a macrometer scale. In this study poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) ([poly(MPC-co-BMA]) was evaluated as a potential coating material for vascular applications to provide smooth catheterization using atomic force microscopy (AFM) techniques.A uniform coating of [poly(MPC-co-BMA] equivalent to a thickness of 2.5 microm on a polyurethane (PU) catheter material was provided using dip casting technique. Using a contact mode AFM, no significant difference in surface roughness (R(a)) and frictional force (f) between uncoated (R(a)=10.2+/-1.9 nm, f=0.907+/-0.02) and coated (R(a)=11.7+/-1.8 nm, f=0.930+/-0.06) surfaces was observed under dry conditions. However, under wet conditions the R(a) of the coated surface (3.4+/-1.0 nm) was significantly lower than uncoated PU surface (9.0+/-1.8 nm). The coating on PU substrate offered the least frictional resistance (f=0.004+/-0.001) illustrating enhanced boundary lubrication capability due to hydration of phosphorylcholine polymer as compared to a significantly higher f for uncoated PU (0.017+/-0.007) surfaces. These tribological and chemical characteristics of the [poly(MPC-co-BMA)] coating could increase the overall efficacy of PU for clinical applications.
Department of Preventive and Restorative Dental Sciences, University of California San Francisco, Box 0758 D2254, San Francisco, CA 94143, USA. sunho@itsa.ucsf.edu
Sunita P
SP
Ho
Nobuo
N
Nakabayashi
Yasuhiko
Y
Iwasaki
Thomas
T
Boland
Martine
M
LaBerge
D002404:Catheterization / Q000295:instrumentation*; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis*; D017276:Friction; D006244:Hardness; D008422:Materials Testing / Q000379:methods*; D008689:Methacrylates / Q000737:chemistry*; D018625:Microscopy, Atomic Force / Q000379:methods*; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000737:chemistry*; D013314:Stress, Mechanical; D013499:Surface Properties; D014867:Water / Q000737:chemistry*
D020099:Coated Materials, Biocompatible; D008689:Methacrylates; D014867:Water; D010767:Phosphorylcholine; C079200:poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate)