Cardiac failure after initiation of insulin treatment in diabetic patients with beta-thalassemia major.
Diabetes mellitus is a complication of beta-thalassemia major. Two patients are described who developed severe cardiac failure after initiation or intensification of insulin treatment. We hypothesize that insulin-induced fluid retention combined with reduced cardiac reserve was responsible for the cardiac failure. Careful initiation of insulin treatment in these patients is important.
Konrad
Daniel
D
Division of Endocrinology, Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
Daneman
Denis
D
Kirby
Melanie
M
Wherrett
Diane
D
D000293:Adolescent; D003925:Diabetic Angiopathies / Q000139:chemically induced*; D016883:Diabetic Ketoacidosis / Q000150:complications* / Q000188:drug therapy*; D004489:Edema, Cardiac / Q000139:chemically induced* / Q000503:physiopathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D007328:Insulin / Q000009:adverse effects*; D017086:beta-Thalassemia / Q000150:complications*
D007004:Hypoglycemic Agents; D007328:Insulin