Comparison of hysteroscopic and hysterectomy findings to assess the diagnostic accuracy of office hysteroscopy in tamoxifen-treated patients with breast cancer.
OBJECTIVE
To assess the diagnostic accuracy of office hysteroscopy by comparing hysteroscopic findings with histologic findings on hysterectomy specimens in postmenopausal women with breast cancer treated with tamoxifen.


METHODS
Retrospective clinical study (Canadian Task Force classification II-2).


METHODS
University-affiliated hospital.


METHODS
Thirty-three women.


METHODS
Record review.


RESULTS
Compared with histologic diagnoses of uteri, hysteroscopic findings showed diagnostic sensitivity of 97%, specificity of 100%, positive predictive value of 100% and negative predictive value of 96%. The diagnostic accuracy of hysteroscopy is the same in patients taking tamoxifen as in the general population.


CONCLUSIONS
Hysteroscopy is a powerful method for diagnosing endometrial disease because it provides a direct view of the uterine cavity, reveals focal lesions, and enables targeted biopsies to be performed at the same time.
Ceci
Oronzo
O
Department of General and Specialty Surgical Science, Section of Obstetrics and Gynecology, University of Bari, Bari, Italy.
Bettocchi
Stefano
S
Nappi
Luigi
L
Di Venere
Raffaella
R
Pansini
Maddalena Valeria
MV
Di Fazio
Francesco
F
D000556:Ambulatory Surgical Procedures; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D007044:Hysterectomy; D015907:Hysteroscopy; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013629:Tamoxifen / Q000627:therapeutic use*
D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen