Lactones from the leaves of Litsea japonica and their anti-complement activity.
Two new lactones, litsealactone A (1) and litsealactone B (2), were isolated from the leaves of Litsea japonica, together with three known lactones, hamabiwalactone A (3), hamabiwalactone B (4), and akolactone B (5). Hamabiwalactone B (4) and akolactone B (5) significantly inhibited complement activity in an in vitro anti-complement assay, with IC(50) values of 149 and 58 muM, respectively.
Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Korea.
Byung Sun
BS
Min
Sun Young
SY
Lee
Jung Hee
JH
Kim
Ok Kyoung
OK
Kwon
Bo Young
BY
Park
Ren Bo
RB
An
Joong Ku
JK
Lee
Hyung In
HI
Moon
Tae Jin
TJ
Kim
Young Ho
YH
Kim
Hyouk
H
Joung
Hyeong Kyu
HK
Lee
D003169:Complement Inactivator Proteins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007723:Korea; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
D003169:Complement Inactivator Proteins; D007783:Lactones