Bioenergetics and transmitter release in the isolated nerve terminal.
The isolated nerve terminal (or synaptosome) is the simplest preparation that allows mitochondrial bioenergetics to be studied in a physiological milieu, as well as facilitating investigation of the protein chemistry and regulation of synaptic vesicle exocytosis and recovery and providing a target for the study of the mechanism of action of numerous neurotoxins. This brief review discusses studies from our laboratory that may have provided some insight into these aspects of nerve terminal function.
Nicholls
David G
DG
Buck Institute for Age Research, Novato, California 94945, USA. dnicholls@buckinstitute.org
D000818:Animals; D004705:Endocytosis; D004734:Energy Metabolism; D005089:Exocytosis; D018698:Glutamic Acid / Q000378:metabolism; D007473:Ion Channels / Q000187:drug effects; D008928:Mitochondria / Q000378:metabolism; D009498:Neurotoxins / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism*
D007473:Ion Channels; D009498:Neurotoxins; D018377:Neurotransmitter Agents; D018698:Glutamic Acid