[Results of international study of quality of life of patients with stable angina treated with nitrates (IQOLAN)].
Effect of transition from multiple administration of short acting nitrates to once daily use of isosorbide-5-mononitrate on angina class and quality of life was studied in 280 patients with stable angina pectoris. Transition to isosorbide-5-mononitrate was associated with increases of (in units) exercise tolerance (Delta=-6.6+/-0.35, p<0.001), satisfaction from treatment (Delta=-2.1+/-0.12, p<0.001), degree of psychological discomfort (Delta=-2.8+/-0.21, p<0.001), decreases of numbers of attacks of angina (Delta=-4.0+/-0.22, p<0.001) and side effects (Delta=-4.1+/-0.29, p<0.001), increase of average distance of walking without chest pain or dyspnea (from 372.1+/-415.1 to 586+/-663.5 m), shortening of duration of episodes of angina (from 4.7+/-4.0 to 4.1+/-7.2 min), significant lowering of angina class (p<0.0001). Thus in patients with ischemic heart disease long acting formulation of isosorbide-5-mononitrate provided rapid onset and stability of therapeutic action what eventually resulted in effective prevention of attacks of angina and improvement of quality of life.
Belenkov
Iu N
IuN
Cardiolgy Research Complex, ul. Tretiya Cherepkovskaya 15a, 121552 Moscow, Russia.
Chazova
I E
IE
Ratova
L G
LG
Dmitriev
V V
VV
Lebedeva
N A
NA
Pavlov
V E
VE
Bishele
N A
NA
Demura
S A
SA
D000787:Angina Pectoris / Q000188:drug therapy* / Q000523:psychology*; D017079:Exercise Tolerance / Q000187:drug effects; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D020030:Nitric Oxide Donors / Q000008:administration & dosage*; D017060:Patient Satisfaction; D011788:Quality of Life; D016896:Treatment Outcome
D020030:Nitric Oxide Donors; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate