[Current therapies for parkinson's disease. Part II: surgical treatment].
Surgical treatment of Parkinson's disease (PD) is indicated in patients with severe neurological symptoms (tremor, bradykinesia, rigidity)--who do not benefit from nor tolerate pharmacological therapy. Surgery for PD modifies the motor system function by lesioning or electrostimulation of thalamic, pallidal or subthalamic nuclei. The technological progress together with refined CNS monitoring enabled wider application of deep brain stimulation (DBS). The efficacy of DBS is comparable with lesioning techniques (thalamotomy or pallidotomy) however bears less adverse effects. Both lesioning and DBS are generally well tolerated by patients. The side effects are mostly transient and neurological complications, if occur, usually do not affect quality of patient's life. Unfortunately, the modern surgery for PD is still very expensive and demanding for a large team of specialists and high technology.
Słowiński
Jerzy
J
Katedry i Oddziału Klinicznego Neurochirurgii i Neurotraumatologii SlAM w Bytomiu. slowian@mp.pl
Wharen
Robert E
RE
Uitti
Ryan J
RJ
Wszolek
Zbigniew K
ZK
Krygowska-Wajs
Anna
A
Mrówka
Ryszard
R
D004599:Electric Stimulation Therapy / Q000295:instrumentation; D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D019635:Neurosurgical Procedures / Q000379:methods*; D010300:Parkinson Disease / Q000601:surgery*; D020531:Subthalamic Nucleus / Q000601:surgery*; D013788:Thalamus / Q000601:surgery*