Effects of 0.2 T static magnetic field on human skin fibroblasts.
Human skin fibroblasts were exposed to 0.2 T static magnetic field generated by a magnetic resonance tomograph. After 1h exposure, cell morphology was modified in association with a concomitant decrease in the expression of some sugar residues of glycoconjugates. Study of cell proliferation and mitogenic signal transduction showed a decrease of thymidine incorporation and of second messenger formation. However, cell viability, assessed by colony forming assay, was unaffected. These results demonstrate that the static magnetic field generated by routinely used magnetic resonance tomograph induces alterations on human skin fibroblasts.
Pacini
Stefania
S
Department of Human Anatomy, Histology and Forensic Medicine, University of Firenze, viale Morgagni 85, 50134, Firenze, Italy.
Gulisano
Massimo
M
Peruzzi
Benedetta
B
Sgambati
Eleonora
E
Gheri
Gherardo
G
Gheri Bryk
Silvia
S
Vannucchi
Simonetta
S
Polli
Gianni
G
Ruggiero
Marco
M
D002455:Cell Division; D002460:Cell Line; D002470:Cell Survival; D005347:Fibroblasts / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D037102:Lectins / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D015290:Second Messenger Systems
D037102:Lectins; D019158:N-Acetylneuraminic Acid