Genome-wide scan of Swedish families with hereditary prostate cancer: suggestive evidence of linkage at 5q11.2 and 19p13.3.
BACKGROUND
Prostate cancer (CaP) is a common disorder with multiple genetic and environmental factors contributing to the disease. CaP susceptibility loci can be identified through genome-wide scans of high-risk families.


METHODS
Allele sharing at 405 markers, distributed across the genome, among 50 families with hereditary prostate cancer, ascertained throughout Sweden, was evaluated through linkage analyses. Genotype data were analyzed utilizing multipoint parametric and non-parametric methods.


RESULTS
Two regions provided suggestive evidence for linkage: 19p13.3 (marker D19S209, LOD = 2.91, P = 0.0001) and 5q11.2 (marker D5S407, LOD = 2.24, P = 0.0007). Additional regions with moderate evidence for linkage in the complete set of families, or stratified subsets, were observed on chromosome 1, 4, 6, 7, 8, and X.


CONCLUSIONS
Our results provide strong confirmatory evidence of linkage at 19q13.3 and 5q11.2. The lack of confirmation of linkage at several loci identified in other genome-wide scans emphasizes the need to combine linkage data between research groups.
Department of Radiation Sciences, Oncology, University of Umeå, Umeå, Sweden. fredrik.wiklund@oc.umu.se
Fredrik
F
Wiklund
Elizabeth M
EM
Gillanders
Julie A
JA
Albertus
Anders
A
Bergh
Jan-Erik
JE
Damber
Monica
M
Emanuelsson
Diana L
DL
Freas-Lutz
Derek E
DE
Gildea
Ingela
I
Göransson
MaryPat S
MS
Jones
Björn-Anders
BA
Jonsson
Fredrik
F
Lindmark
Carol J
CJ
Markey
Erica L
EL
Riedesel
Elisabeth
E
Stenman
Jeffry M
JM
Trent
Henrik
H
Grönberg
D000368:Aged; D000483:Alleles; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D004273:DNA, Neoplasm / Q000737:chemistry / Q000235:genetics; D005190:Family; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011471:Prostatic Neoplasms / Q000235:genetics*; D017422:Sequence Analysis, DNA; D018709:Statistics, Nonparametric; D013548:Sweden
D004273:DNA, Neoplasm