Screening for hepatitis C in genito-urinary medicine clinics: a cost utility analysis.
OBJECTIVE
To estimate the cost utility (cost per QALY) of screening for hepatitis C (HCV) infection in people attending genito-urinary medicine clinics in England.


METHODS
An epidemiological model of screening and diagnosis was combined with a Markov chain model of treatment with combination therapy to estimate cost utility. Parameters for the model were informed by literature review, expert opinion and a survey of current screening practice.


RESULTS
The base case estimate was about pound 85,000 per QALY. Selective screening is more cost effective. If screening is restricted to only 20% or 10% of attenders, cost utility is estimated as pound 39,647 and pound 34,288 per QALY. If screening is restricted only to those with a history of injecting drug use, cost utility would be pound 27,138 per QALY. Estimates are particularly sensitive to acceptance rates for screening and treatment.


CONCLUSIONS
Universal screening for HCV in GUM clinics is unlikely to be cost effective. There is limited evidence to support screening of people other than those with a history of injecting drug use and even this policy should be considered with some care and in the context of further research.
Stein
Ken
K
Peninsula Technology Assessment Group, University of Exeter, Southernhay East, Exeter EX1 1PQ, UK. ken.stein@exeter.ac.uk
Dalziel
Kim
K
Walker
Andrew
A
Jenkins
Becky
B
Round
Alison
A
Royle
Pam
P
D000554:Ambulatory Care Facilities; D000998:Antiviral Agents / Q000627:therapeutic use; D003362:Cost-Benefit Analysis; D016527:Drug Costs; D004359:Drug Therapy, Combination; D004739:England / Q000453:epidemiology; D052776:Female Urogenital Diseases; D006526:Hepatitis C / Q000175:diagnosis* / Q000188:drug therapy / Q000191:economics* / Q000453:epidemiology; D006801:Humans; D052801:Male Urogenital Diseases; D008390:Markov Chains; D008403:Mass Screening / Q000191:economics*; D015233:Models, Statistical; D019057:Quality-Adjusted Life Years
D000998:Antiviral Agents