Vaccination with Toxoplasma gondii SAG-1 protein is protective against congenital toxoplasmosis in BALB/c mice but not in CBA/J mice.
We evaluated the effect of vaccination with the SAG1 protein of Toxoplasma gondii against congenital toxoplasmosis in mice with different genetic backgrounds. In BALB/c mice (H-2(d)), vaccination reduced the number of infected fetuses by 50% and was associated with a mixed type 1 and type 2 immunity. In CBA/J mice (H-2(k)), vaccination increased the number of infected fetuses by 50% and was associated with a predominant type 2 response. Our results indicate that the effect of vaccination with SAG1 is controlled by the genetic background of the mouse.
Institut de Parasitologie et de Pathologie Tropicale, INSERM U 392, Faculté de Médecine, Université de Strasbourg, 67000 Strasbourg, France. valerie.letscher@medecine.u-strasbg.fr
Valerie
V
Letscher-Bru
Alexander W
AW
Pfaff
Ahmed
A
Abou-Bacar
Denis
D
Filisetti
Elisabeth
E
Antoni
Odile
O
Villard
Jean-Paul
JP
Klein
Ermanno
E
Candolfi
D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D000953:Antigens, Protozoan / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D007114:Immunization; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D015800:Protozoan Proteins / Q000276:immunology*; D016052:Protozoan Vaccines / Q000276:immunology*; D013045:Species Specificity; D014122:Toxoplasma / Q000276:immunology*; D014125:Toxoplasmosis, Congenital / Q000517:prevention & control*; D014611:Vaccination
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D016207:Cytokines; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; C047168:SAG1 antigen, Toxoplasma