Evaluation of in vitro antiviral activity in methanol extracts against in fl uenza virus type A from Korean medicinal plants.
Methanol extracts from 101 Korean medicinal plants were tested for inhibitory activity against influenza virus type A by means of a modified haemagglutination inhibition (HI) test. MM-57, MM-72, MM-104 and MM-110, four of 101 extracts tested exhibited strong anti-influenza virus type A activity at concentration ranges of 0.78-6.25 mg/mL, 0.78-3.13 mg/mL, 0.78-1.56 mg/mL and 0.0975-0.39 mg/mL, respectively. The extracts MM-57, MM-72 and MM-110 showed very strong anti-influenza virus type A activity in the range 1.56-6.25 mg/mL, 1.56-3.13 mg/mL and 195-390 micro g/mL, respectively. The four methanol extracts were weakly cytotoxic to red blood cells. These results demonstrated that four methanol extracts of Korean medicinal plants exhibit strong anti-influenza virus type A activity, and weak cytotoxic effects. They may inhibit attachment of the virus to the cell and may therefore be used for prophylaxis.
Park
Kap Joo
KJ
Department of Biological Science, Konkuk University, Seoul 143-701, Korea. kkupkj@chol.net
D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects*; D007251:Influenza, Human / Q000188:drug therapy; D007723:Korea; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal
D000998:Antiviral Agents; D010936:Plant Extracts