Sequence analysis of two de novo mutation alleles at the DXS10011 locus.
We have detected two unusual alleles at the DXS10011 locus in two paternity trio cases. In one case, one allele of the daughter was found not to have been derived from the mother but the other allele was shared with the father. In the other case, the mother and the son shared no bands. Paternity in both cases was established using conventional polymorphic markers in addition to DNA markers (probabilities: >0.999999). Sequencing showed that the two de novo alleles of the children acquired a single unit (GAAA).
Department of Legal Medicine, Osaka Medical College, 2-7 Daigakumachi, Takatsuki, Osaka 569-8686, Japan. leg003@art.osaka-med.ac.jp
Akiyoshi
A
Tamura
Misa
M
Iwata
Izumi
I
Takase
Tokiko
T
Miyazaki
Kiyoshi
K
Matsui
Hajime
H
Nishio
Koichi
K
Suzuki
D000483:Alleles; D041321:Chromosomes, Human, X; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D009154:Mutation; D010334:Paternity; D017422:Sequence Analysis, DNA; D020080:Tandem Repeat Sequences
D005819:Genetic Markers