Stu2p and XMAP215: turncoat microtubule-associated proteins?
The dynamics of microtubule-based (MT) cytoskeletons are controlled by a variety of accessory proteins: microtubule-associated proteins (MAPs), which usually stabilize MTs, and microtubule-destabilizers. Two related MAPs, XMAP215 and Stu2p, are known to stabilize MTs. However, recent studies report that these proteins have a MT-destabilizing function as well. Here we discuss the implications of these reports.
Inserm Unité 366, DRDC/CS, CEA-Grenoble, 17 rue des Martyrs, 38054 Grenoble Cedex 9, France.
Andrei V
AV
Popov
Eric
E
Karsenti
D000818:Animals; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000502:physiology*; D008870:Microtubules / Q000235:genetics / Q000502:physiology*; D012441:Saccharomyces cerevisiae; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000502:physiology*; D029867:Xenopus Proteins / Q000502:physiology
C486738:CKAP5 protein, Xenopus; D008869:Microtubule-Associated Proteins; C109414:STU2 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D029867:Xenopus Proteins