A mild and efficient one-step synthesis of quinolines.
[reaction: see text] The Friedländer synthesis of quinolines is an extensively employed protocol, yielding the desired heterocycle in a two-step reduction-condensation sequence. We have developed a mild, efficient, high-yielding single-step variant of this methodology, which employs SnCl(2) and ZnCl(2) to effect the reaction.
Department of Dermatology, The Center for Future Health, University of Rochester, Rochester, New York 14642, USA.
Brian R
BR
McNaughton
Benjamin L
BL
Miller