[Cancer chemotherapy; past, present and future--from the aspect of fundamental studies].
Advances in cancer chemotherapy has been supported greatly by the progresses of the studies of tumor cell biology, development of new anticancer drugs, fundament studies related to drug resistance, biochemical modulation and others. In this paper, biological studies influenced on cancer chemotherapy in early days such as skipper's law, Goldie-Coldman hypothesis and others, development of various anticancer drugs (which were discovered in Japan or abroad), studies of drug resistance, biochemical modulation were briefly reviewed. Also in the near future, some novel molecular-targeted drugs will serve as the useful anticancer drugs.
Tokyo Cooperative Oncology Group, 111 Bancho-heim, 1 Niban-cho, Chiyoda-ku, Tokyo 102-0084, Japan.
Shigeru
S
Tukagoshi
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor / Q000592:standards; D006801:Humans; D008495:Medical Oncology / Q000639:trends*; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents