Folic acid-conjugated nanostructured materials designed for cancer cell targeting.
Shell cross-linked nanoparticles (SCKs) constitute a unique class of materials with amphiphilic core-shell morphology; SCKs are characterised by their structural integrity and available functionality to attach receptor-recognising or receptor-specific ligands on the shell surface and, therefore, hold great potential in drug delivery applications; in an attempt to develop novel, cancer cell specific delivery vehicles, folate receptor targeted SCKs have been prepared.
Pan
Dipanjan
D
Department of Chemistry, Washington University, One Brookings Drive, CB 1134, Saint Louis, Missouri 63130, USA.
Turner
Jeffrey L
JL
Wooley
Karen L
KL
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics; D002352:Carrier Proteins / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D015195:Drug Design; D058973:Folate Receptors, GPI-Anchored; D005492:Folic Acid / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D036103:Nanotechnology; D011092:Polyethylene Glycols / Q000737:chemistry / Q000493:pharmacokinetics; D011956:Receptors, Cell Surface / Q000378:metabolism*
D000970:Antineoplastic Agents; D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D008024:Ligands; D011956:Receptors, Cell Surface; D011092:Polyethylene Glycols; D005492:Folic Acid