Preparation of methyl (1R,2S,5S)- and (1S,2R,5R)-2-amino-5-tert-butyl-cyclopentane-1-carboxylates by parallel kinetic resolution of methyl (RS)-5-tert-butyl-cyclopentene-1-carboxylate.
Comparison of the kinetic and parallel kinetic resolutions of methyl (RS)-5-tert-butyl-cyclopentene-1-carboxylate allows for the efficient synthesis of both (1R,2S,5S)- and (1S,2R,5R)-enantiomers of methyl 2-amino-5-tert-butyl-cyclopentane-1-carboxylate.
The Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, UK OX1 3QY. steve.davies@chemistry.oxford.ac.uk
Stephen G
SG
Davies
David
D
Díez
Mohamed M
MM
El Hammouni
A Christopher
AC
Garner
Narciso M
NM
Garrido
Marcus J C
MJ
Long
Rachel M
RM
Morrison
Andrew D
AD
Smith
Miles J
MJ
Sweet
Jonathan M
JM
Withey