[Role of DNA diagnosis in modern oncology].
DNA-diagnosis became to be a mandatory element of the modern oncological care. The molecular-genetic approaches aimed at identifying the high-risk categories in oncology are mostly-renowned. They comprise the diagnosis of the so-called familial cancerous syndromes, the identification of unfavorable normal genome variations (gene polymorphisms) and the detection of a number of oncoviral infections. Laboratory procedures facilitating the individualization of treatment schemes and the monitoring of oncology patients have been widely introduced into clinical practice. The turn between the 20th and 21st centuries was marked by the emergence of principally new DNA-analysis methods designed for a comprehensive and integral genome evaluation. The application of such radically novel techniques in the molecular diagnostics essentially promoted the detection and treatment of neoplasms.
Imianitov
E N
EN
Khanson
K V
KV
D002471:Cell Transformation, Neoplastic; D004247:DNA / Q000235:genetics*; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D005819:Genetic Markers; D005821:Genetic Techniques; D006801:Humans; D008297:Male; D008967:Molecular Biology; D025202:Molecular Diagnostic Techniques; D008991:Monitoring, Physiologic; D009154:Mutation; D009364:Neoplasm Recurrence, Local; D009369:Neoplasms / Q000175:diagnosis* / Q000235:genetics* / Q000517:prevention & control / Q000628:therapy; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014777:Virus Diseases / Q000150:complications
D004273:DNA, Neoplasm; D005819:Genetic Markers; D004247:DNA