Comparative effect of physiological levels of leptin and insulin on cyclic AMP-induced stimulation of hepatic glycogen breakdown.
Physiological level of insulin showed more prominent inhibiting effect on the activation of hepatic glucose production and glycogenolysis promoted by cAMP than physiological levels of leptin.
Department of Pharmacy and Pharmacology, University of Maringá, 87020-900 Maringá, PR, Brasil. rbbazotte@uem.br
Márcia
M
Vardanega-Peicher
Rue
R
Curi
Helenir M
HM
Souza
Glaucia R
GR
Borba-Murad
V L D
VL
Siqueira
Sharize
S
Galende
Roberto B
RB
Bazotte
D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism* / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism* / Q000494:pharmacology; D020738:Leptin / Q000378:metabolism* / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D007328:Insulin; D020738:Leptin; D015124:8-Bromo Cyclic Adenosine Monophosphate; D006003:Glycogen; D000242:Cyclic AMP; D005947:Glucose