Thrombophilia does not increase risk for neonatal complications in preterm infants.
The association between thrombophilia and neonatal complications was evaluated in a single-center prospective study. Prevalence of genetic prothrombotic markers (FVL, MTHFR, FIIG20210A) and levels of plasma homocysteine were assayed in 166 premature (mean gestational age: 30.9+/-2.3 weeks) and low birth weight (mean weight: 1327+/-319 grams) infants. The incidence of any neonatal complications was compared in infants with and without thrombophilia. A total of 38 infants were defined as "thrombophilic" due to heterozygous FVL (n=4) and/or FIIG20210A (n=8, including one case of combination with FVL) or homozygous 677T MTHFR (n=22) or homocysteine plasma levels above 15 micro mole/liter. Neonatal complications included: small for gestational age (28.8%), respiratory distress syndrome (51.8%), broncho-pulmonary dysplasia (10.2%), patent ductus arteriosus (12.7%), intraventricular hemorrhage (17%), periventricular leucomalacia (8.4%), retinopathy of prematurity (15.1%) and necrotizing enterocolitis in 1.2% of infants. No thrombosis was documented. The prevalence of perinatal complications and the severity of diseases were similar among infants with or without thrombophilia (p = 0.564). Our data suggest that preterm infants with thrombophilia are not at increased risk for developing neonatal complications.
The Pediatric Coagulation Service, Institute of Thrombosis and Hemostasis, Sackler School of Medicine, Tel-Aviv University, Israel.
Gili
G
Kenet
Ayala
A
Maayan-Metzger
Nurit
N
Rosenberg
Ben-Ami
BA
Sela
Ram
R
Mazkereth
Aviyah
A
Ifrah
Jacob
J
Kuint
D016022:Case-Control Studies; D004198:Disease Susceptibility; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D007235:Infant, Premature, Diseases / Q000097:blood / Q000209:etiology*; D015995:Prevalence; D011446:Prospective Studies; D012306:Risk; D019851:Thrombophilia / Q000150:complications* / Q000175:diagnosis