Cell cycle control in glomerular disease.
Glomerular diseases are a leading caused of kidney failure. The three resident glomerular cell types respond differently to injury, which includes proliferation, hypertrophy, apoptosis and de-differentiation. Each leads to glomerular scarring, and a decline in renal function. Studies have shown that these events are critically controlled by cell cycle regulatory proteins, providing potential targets for the development of future therapeutics.
Wolf
Gunter
G
Department of Medicine, Division of Nephrology, University of Hamburg, Hamburg, Germany.
Shankland
Stuart J
SJ
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D018797:Cell Cycle Proteins / Q000187:drug effects / Q000378:metabolism*; D005920:Glomerular Mesangium / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology; D005921:Glomerulonephritis / Q000188:drug therapy / Q000201:enzymology* / Q000503:physiopathology; D006801:Humans; D006984:Hypertrophy / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D023421:Models, Animal
D018797:Cell Cycle Proteins