Regulation of the eukaryotic cell cycle.
The sundry cellular processes required to successfully replicate and divide cells are driven by the sequential activation and inactivation of a family of cyclin dependent kinases. Activation is driven predominately by the periodic expression of the cyclin subunit and requires activating phosphorylation of the kinase subunit. Inactivation is controlled by inhibitory phosphorylation of the kinase subunit, by ubiquitin-mediated degradation of the cyclin subunit and by interaction of the complex with small inhibitory proteins. The mechanisms that coordinate cell cycle progression under favorable and adverse conditions are reviewed.
Department of Molecular Biology, Department of Cell Biology, Scripps Research Institute, La Jolla, California 92037, USA.
Clare H
CH
McGowan
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000502:physiology*; D018816:Genes, cdc / Q000502:physiology; D006801:Humans; D010766:Phosphorylation; D021122:Protein Subunits / Q000378:metabolism
D018797:Cell Cycle Proteins; D021122:Protein Subunits; D018844:Cyclin-Dependent Kinases