Palmoplantar keratoderma of Sybert.
A 13-year-old boy and a 7-year-old boy, who are brothers, presented with a life-long history of erythema, hyperkeratosis, and desquamation of the hands and feet. Symptoms improved with the use of topical glucocorticoids and keratolytics. PPK of Sybert is characterized by palmoplantar hyperkeratosis with transgrediens, autosomal dominant inheritance, and the absence of associated systemic features.
Ronald O. Perelman Department of Dermatology, New York University, USA.
Aimee L
AL
Leonard
Irwin M
IM
Freedberg
D000287:Administration, Topical; D000293:Adolescent; D002648:Child; D005799:Genes, Dominant; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D007641:Keratolytic Agents / Q000627:therapeutic use; D008297:Male; D020156:Salicylic Acid / Q000627:therapeutic use; D035781:Siblings
D005938:Glucocorticoids; D007641:Keratolytic Agents; D020156:Salicylic Acid