Ionic liquid as a suitable phase for multistep parallel synthesis of an array of isoxazolines.
[reaction: see text]. A parallel array of isoxazoline diamides was prepared using an ionic liquid [bmim][BF4] as the phase where a three-step procedure (Schotten-Baumann, 1,3-dipolar cycloaddition, ester amidation with Me3Al) was carried out. At the end, selective extraction of the final products with diethyl ether allowed simple isolation of the 16 components of the array (Syncore technology).
Rodriquez
Manuela
M
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy.
Sega
Alessandro
A
Taddei
Maurizio
M