Abdominal malignant mesothelioma following autologous bone marrow transplantation: a case report.
Secondary malignancies are a well-known late complication occurring in patients who undergo bone marrow transplant (BMT) during childhood. A boy with acute lymphoblastic leukemia experienced a BM relapse at the age of 14 years and underwent an autologous BMT conditioned with TBI and melphalan. Sixteen years later a malignant mesothelioma of the peritoneum was diagnosed. A surgical approach according to the Sugarbaker technique and hyperthermic peritoneal perfusion with CDDP and Adriamycin were performed. The patient is alive and well after a follow-up of 20 months. To the authors' knowledge this is the first case of mesothelioma as a secondary malignancy after BMT.
Miniero
R
R
Department of Pediatrics, San Luigi Hospital, University of Turin, Turin, Italy. roberto.miniero@unito.it
Tardivo
I
I
De Simone
M
M
Gubetta
L
L
Orecchia
S
S
Cacciotti
P
P
Gorzegno
G
G
D000008:Abdominal Neoplasms / Q000209:etiology*; D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000175:diagnosis / Q000209:etiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000601:surgery; D014182:Transplantation, Autologous