Gradual adaptation of HIV to human host populations: good or bad news?
The continuous evolution and adaptation of HIV to its host has produced extensive global viral diversity. Understanding the kinetics and directions of this continuing adaptation and its impact on viral fitness, immunogenicity and pathogenicity will be crucial to the successful design of effective HIV vaccines. Here we discuss some potential scenarios of viral and host coevolution.
Brander
Christian
C
Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA. cbrander@partners.org
Walker
Bruce D
BD
D000220:Adaptation, Biological / Q000276:immunology; D000818:Animals; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D019143:Evolution, Molecular; D006678:HIV / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D006790:Host-Parasite Interactions / Q000235:genetics / Q000276:immunology / Q000502:physiology; D006801:Humans; D015302:Simian Immunodeficiency Virus / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D018984:Epitopes, T-Lymphocyte