A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population.
We have systematically screened the genome for evidence of linkage disequilibrium (LD) with multiple sclerosis (MS) by typing 6000 microsatellite markers in case-control and family based (AFBAC) cohorts from the Italian population. DNA pooling was used to reduce the genotyping effort involved. Four DNA pools were considered: cases (224 Italian MS patients), controls (231 healthy Italians), index (185 index cases from trio families) and parents (the 370 parents of the patient included in the Index pool), respectively. After refining analysis of the most promising 14 markers to emerge from this screening process, only marker D2S367 retained evidence for association.
Liguori
Maria
M
Dipartimento di Scienze Neurologiche e Psichiatriche, Univ. Bari, Italy.
Sawcer
Stephen
S
Setakis
Efrosini
E
Compston
Alastair
A
Giordano
Mara
M
D'Alfonso
Sandra
S
Mellai
Marta
M
Malferrari
Giulia
G
Trojano
Maria
M
Livrea
Paolo
P
De Robertis
Francesca
F
Massacesi
Luca
L
Repice
Anna
A
Ballerini
Clara
C
Biagioli
Tiziana
T
Bomprezzi
Roberto
R
Cannoni
Stefania
S
Ristori
Giovanni
G
Salvetti
Marco
M
Grimaldi
Luigi M E
LM
Biunno
Ida
I
Comi
Giancarlo
G
Leone
Maurizio
M
Ferro
Isabella
I
Naldi
Paola
P
Milanese
Clara
C
Gellera
Cinzia
C
Loredana
La Mantia
LM
Savettieri
Giovanni
G
Salemi
Giuseppe
G
Aridon
Paolo
P
Caputo
Domenico
D
Rosa Guerini
Franca
F
Ferrante
Pasquale
P
Momigliano-Richiardi
Patricia
P
D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods / Q000706:statistics & numerical data; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D007391:International Cooperation; D007558:Italy / Q000453:epidemiology; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D044469:Racial Groups / Q000235:genetics