Multiple eruptive dermatofibromas with CD34+ cells in a patient with hypertriglyceridemia.
Multiple eruptive dermatofibromas (MEDF) are rare and have been thought to be associated with altered immunity. It has been reported that dermatofibromas (DFs) are positive for factor X IIIa but not for CD34. In this report, we describe a 34-year-old Japanese woman with MEDF and persistent hypertriglyceridemia. Histopathological examination revealed that several areas in larger nodules, showing higher cellularity and storiform growth pattern, had CD34+ cells. Our case and the review of previous reports suggest that hyperlipidemia, including hypertriglyceridemia, could induce MEDF and that highly cellular areas in DFs are sometimes positive for CD34.
Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan. ytsun-tky@umin.ac.jp
Yuichiro
Y
Tsunemi
Hironobu
H
Ihn
Naoko
N
Hattori
Hidehisa
H
Saeki
Kunihiko
K
Tamaki
D000328:Adult; D018952:Antigens, CD34 / Q000276:immunology; D001707:Biopsy, Needle; D005260:Female; D005500:Follow-Up Studies; D018219:Histiocytoma, Benign Fibrous / Q000150:complications / Q000276:immunology / Q000473:pathology*; D006801:Humans; D015228:Hypertriglyceridemia / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D007150:Immunohistochemistry; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000150:complications / Q000276:immunology / Q000473:pathology*
D018952:Antigens, CD34