Interaction of Ginkgo biloba extract (GBE) with hypotensive agent, nicardipine, in rats.
The effect of Ginkgo biloba extract (GBE, 0.5%) orally administered for 2 weeks on the antihypertensive action of oral nicardipine was examined in Wistar rats. GBE significantly increased hepatic P-450 content and reduced the hypotensive effect of nicardipine. GBE administration resulted in a significant decrease in maximal nicardipine plasma concentration (Cmax) and the 23-hour area under the curve (AUC0-23). Thus, it is suggested that GBE attenuated the therapeutic potency of nicardipine, probably secondary to increased hepatic drug metabolism.
Department of Pharmacology, School of Pharmaceutical Sciences, Research Institute for Biosciences, Mukogawa Women's University, Nishinomiya 663-8179, Japan.
Yoko
Y
Kubota
Kyoko
K
Kobayashi
Naoka
N
Tanaka
Kazuki
K
Nakamura
Masaru
M
Kunitomo
Keizo
K
Umegaki
Kazumasa
K
Shinozuka
D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D019540:Area Under Curve; D001219:Aspartate Aminotransferases / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004032:Diet; D004336:Drug Antagonism; D004347:Drug Interactions; D020441:Ginkgo biloba / Q000737:chemistry; D006339:Heart Rate / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D009529:Nicardipine / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats
D000959:Antihypertensive Agents; D010936:Plant Extracts; D003577:Cytochrome P-450 Enzyme System; D009529:Nicardipine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase