Carbocyclic isoadenosine analogues of neplanocin A.
[structure: see text] Isoadenosine (IsoA), a structural isomer of adenosine, was shown to possess interesting biological activity but was inherently unstable. In an effort to overcome this, we have designed a series of carbocyclic IsoA analogues, combining the unique connectivity of IsoA with the structural features of some biologically significant Neplanocin A analogues. Their design, synthesis, and structural elucidation is reported.
Seley
Katherine L
KL
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA. kseley@umbc.edu
Mosley
Sylvester L
SL
Zeng
Fanxing
F
D000241:Adenosine / Q000031:analogs & derivatives* / Q000737:chemistry*
C031096:neplanocin A; D000241:Adenosine