Correlation of redox potentials and inhibitory effects on Epstein-Barr virus activation of naphthoquinones.
As a continuation of our studies using natural and synthetic products as cancer chemopreventive agents, we examined the standard redox potentials of some naphthoquinones in phosphate buffer at pH 7.2 by means of cyclic voltammetry. A definite correlation has been found between the redox potentials and the inhibitory effects of the naphthoquinones on Epstein-Barr virus early antigen activation. It has been further shown that the correlation can be enhanced by introducing an electronic property, i.e. the atomic charges at the C(4) and O(10) atoms in the quinone skeleton ring as additional parameters.
Faculty of Pharmaceutical Sciences, Kobe Pharmaceutical University, Higashinada, Kobe 658, Japan. j-koyama@kobepharma-u.ac.jp
Junko
J
Koyama
Izumi
I
Morita
Norihiro
N
Kobayashi
Toshiyuki
T
Osakai
Hiroki
H
Hotta
Junko
J
Takayasu
Hoyoku
H
Nishino
Harukuni
H
Tokuda
D000818:Animals; D000956:Antigens, Viral / Q000187:drug effects / Q000502:physiology*; D004563:Electrochemistry; D004854:Herpesvirus 4, Human / Q000187:drug effects / Q000502:physiology*; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology*; D010084:Oxidation-Reduction; D014775:Virus Activation / Q000187:drug effects*
D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D009285:Naphthoquinones