Petrosal sinus sampling in the diagnosis of Cushing's syndrome: preliminary experience in University of Malaya Medical Centre.
Differentiating between Cushing's disease of pituitary origin and ectopic ACTH syndrome of extra-pituitary origin remains a major challenge to the clinician because of limitations in the diagnostic accuracy of the high-dose dexamethasone suppression test. Routine use of inferior petrosal sinus sampling (IPSS) is therefore advocated by some authors for these patients. We present our preliminary experience of IPSS in 7 consecutive patients with Cushing's disease and discuss how the results impacted on the patients' management.
Norlisah
R
R
Department of Radiology, Department of Medicine, University of Malaya Medical Centre, 50603, Kuala Lumpur.
Abdullah
B J
BJ
Hew
F L
FL
Chan
S P
SP
D000046:Academic Medical Centers; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003480:Cushing Syndrome / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D006801:Humans; D008296:Malaysia; D008297:Male; D008875:Middle Aged; D017591:Petrosal Sinus Sampling; D015203:Reproducibility of Results
D000324:Adrenocorticotropic Hormone