Upstream of Ikaros.
Haematopoiesis - the process by which pluripotent haematopoietic stem cells choose to become lymphocytes, myeloid cells, red blood cells or platelets - has long been a useful model to study cellular commitment and differentiation. Each cell type is defined by lineage-specific patterns of gene expression. The DNA binding protein Ikaros is an important regulator of haematopoiesis and recent work promises to shed light on how Ikaros itself is regulated.
Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, W12 0NN, London, UK. david.liberg@csc.mrc.ac.uk
David
D
Liberg
Stephen T
ST
Smale
Matthias
M
Merkenschlager
D000818:Animals; D004268:DNA-Binding Proteins; D005091:Exons; D018507:Gene Expression Regulation, Developmental; D006410:Hematopoiesis; D051740:Ikaros Transcription Factor; D051379:Mice; D011401:Promoter Regions, Genetic; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
D004268:DNA-Binding Proteins; D014157:Transcription Factors; C497238:Zfpn1a1 protein, mouse; D051740:Ikaros Transcription Factor