Relative resistance of Pacific salmon to infectious salmon anaemia virus.
Infectious salmon anaemia (ISA) is a major disease of Atlantic salmon, Salmo salar, caused by an orthomyxovirus (ISAV). Increases in global aquaculture and the international movement of fish made it important to determine if Pacific salmon are at risk. Steelhead trout, Oncorhynchus mykiss, and chum, O. keta, Chinook, O. tshawytscha, coho, O. kisutch, and Atlantic salmon were injected intraperitoneally with a high, medium, or low dose of a Norwegian strain of ISAV. In a second challenge, the same species, except chum salmon, were injected with a high dose of either a Canadian or the Norwegian strain. Average cumulative mortality of Atlantic salmon in trial 1 was 12% in the high dose group, 20% in the medium dose group and 16% in the low dose group. The average cumulative mortality of Atlantic salmon in trial 2 was 98%. No signs typical of ISA and no ISAV-related mortality occurred among any of the groups of Oncorhynchus spp. in either experiment, although ISAV was reisolated from some fish sampled at intervals post-challenge. The results indicate that while Oncorhynchus spp. are quite resistant to ISAV relative to Atlantic salmon, the potential for ISAV to adapt to Oncorhynchus spp. should not be ignored.
Rolland
J B
JB
Western Fisheries Research Center, United States Geological Survey, Seattle, WA 98115, USA.
Winton
J R
JR
D000818:Animals; D017756:Aquaculture; D001267:Atlantic Ocean; D005393:Fish Diseases / Q000276:immunology / Q000401:mortality*; D007113:Immunity, Innate / Q000276:immunology*; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000662:veterinary*; D010140:Pacific Ocean; D012474:Salmon / Q000276:immunology / Q000821:virology*