Protein-based signaling systems in tissue engineering.
Tissue engineering aims to replace damaged tissues or organs using either transplanted cells or host cells recruited to the target site. Protein signaling is crucial to regulate cell phenotype and thus engineered tissue structure and function. Biomaterial vehicles are being designed to incorporate and locally deliver various molecules involved in this signaling, including both growth factors and peptides that mimick whole proteins. Controlling the concentration, local duration and spatial distribution of these factors is key to their utility and efficacy. Recent advances have been made in the development of polymeric delivery systems intended to achieve this control.
Boontheekul
Tanyarut
T
University of Michigan, 1011 North University Avenue, 5213 Dental Building, Ann Arbor, MI 48109-1078, USA.
Mooney
David J
DJ
D001672:Biocompatible Materials / Q000378:metabolism*; D001861:Bone Regeneration; D004800:Enzymes, Immobilized / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D018919:Neovascularization, Physiologic; D015398:Signal Transduction; D023822:Tissue Engineering / Q000379:methods*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D014945:Wound Healing
D001672:Biocompatible Materials; D004800:Enzymes, Immobilized; D036341:Intercellular Signaling Peptides and Proteins; D042461:Vascular Endothelial Growth Factor A