Epileptogenic activity induced by histamine H(1) antagonists in amygdala-kindled rats.
The epileptogenic activities induced by histamine H(1) antagonists in amygdala-kindled rats were studied in comparison with activities in nonkindled rats (sham rats). Intraperitoneal injection of pyrilamine, diphenhydramine and ketotifen resulted in behavioral and electroencephalogram (EEG)-detected seizures in amygdala-kindled rats at doses which caused no or negligible seizures in sham rats. On the other hand, loratadine and cetirizine caused no behavioral or EEG seizures in either amygdala-kindled or sham rats even at a dose of 40 mg/kg. In conclusion, first-generation H(1) antagonists likely elicit epileptogenic activity in amygdala-kindled rats more potent than that in sham rats.
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima-naka 1-1-1, Okayama 700-8530, Japan.
Yoko
Y
Fujii
Takehiro
T
Tanaka
Chie
C
Harada
Tadashi
T
Hirai
Chiaki
C
Kamei
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D017332:Cetirizine / Q000008:administration & dosage / Q000494:pharmacology; D004155:Diphenhydramine / Q000008:administration & dosage / Q000494:pharmacology; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000139:chemically induced*; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007665:Ketotifen / Q000008:administration & dosage / Q000494:pharmacology; D007696:Kindling, Neurologic / Q000187:drug effects*; D017336:Loratadine / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D011738:Pyrilamine / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D006634:Histamine H1 Antagonists; D017336:Loratadine; D004155:Diphenhydramine; D011738:Pyrilamine; D007665:Ketotifen; D017332:Cetirizine