Safe and successful endoarterial infusion of liposomal amphotericin B in treatment of mucormycosis.
Mucormycosis is a rare invasive mycotic infection treated by antifungini or amphotericin B. We describe the case of a patient with septic fever and a necrotic lesion, with phlegmon of medial left thigh. Surgery was performed to drain the abscess content and to remove the necrotic tissue; mucormycosis was diagnosized by histological and culture tests and treated by intravenous amphotericin B. Since the lesion worsened, liposomal amphotericin B was directly infused into the left common iliac artery, with progressive improvement, and treatment was continued until complete recovery. Therefore, the endoarterial infusion of liposomal amphotericin B was a safe and successful treatment of advanced lesions of mucormycosis. In such lesions, intravenous general antibiotic administration probably is not sufficient to reach the whole infected area.
Department of Clinical Medicine and Emerging Diseases, University of Palermo, Italy.
P
P
Mansueto
M
M
Rizzo
M
M
Affronti
R
R
Malta
E
E
Carmina
S
S
Mansueto
M
M
Masellis
G B
GB
Rini
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D003937:Diagnosis, Differential; D006801:Humans; D007261:Infusions, Intra-Arterial; D008081:Liposomes / Q000008:administration & dosage; D008297:Male; D009091:Mucormycosis / Q000175:diagnosis / Q000188:drug therapy*
D000935:Antifungal Agents; D008081:Liposomes; D000666:Amphotericin B