Ifosfamide with regional hyperthermia in soft-tissue sarcomas.
For high-risk soft tissue sarcomas (HR-STS) of adults, new treatment strategies are needed to improve outcome with regard to local control and overall survival. Therefore, systemic chemotherapy has been integrated either after (adjuvant) or before (neoadjuvant) optimal local treatment by surgery and radiotherapy in HR-STS. The combination with regional hyperthermia as a new treatment strategy seems to open a new therapeutic window.
Schlemmer
M
M
Department of Internal Medicine III, Klinikum Grosshadern Medical Center, Ludwig Maximilians University Munich, Munich, Germany.
Wendtner
C M
CM
Issels
R D
RD
D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D006801:Humans; D006979:Hyperthermia, Induced; D007069:Ifosfamide / Q000627:therapeutic use*; D020360:Neoadjuvant Therapy; D012509:Sarcoma / Q000188:drug therapy*
D018906:Antineoplastic Agents, Alkylating; D007069:Ifosfamide