[Experimental study of the effect of sodium nitrate on the functional neutrophil and macrophage activity].
The impact of sodium nitrite on functional activity of macrophages and neutrophiles of the abdominal cavity and blood of mice BALB/c was investigated in vitro and in vivo experiments. Functional activity was estimated according to formation of oxygen active forms. It was shown that sodium nitrite significantly inhibits formation of reactive oxygen species released from mouse peritoneal neutrophiles and macrophages, when they are being activated in vitro. Sodium nitrite was given in water at concentration 500.0 mg/l mice for 210 days immunodepression action was revealed which expressed reduction by leukopoes and decrease functional activity of blood neutrophils. Under the same conditions nitrite did not effect on functional activity of resident peritoneal macrophages.
Deriagina
V P
VP
Cancer Research Center, Russian Academy of Medical Sciences, Moscow 115478, Kashirskoe Shosse.
Mashkovtsev
Iu V
IuV
Il'nitskiĭ
A P
AP
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007958:Leukocyte Count; D007970:Leukopenia / Q000139:chemically induced; D008163:Luminescent Measurements; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D009566:Nitrates / Q000633:toxicity*; D010529:Peritoneal Cavity / Q000166:cytology; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors / Q000378:metabolism
D009566:Nitrates; D017382:Reactive Oxygen Species; C031618:sodium nitrate