Molecular mutations in thyroid carcinogenesis.
Molecular mutations in thyroid carcinomas have been well characterized and studied and consist of both germline and somatic genetic events. Mutations that are associated with tumorigenesis can be divided into 2 general categories: oncogene mutations and tumor suppressor gene mutations. Thyroid tumors and their characteristic molecular mutations are discussed in this review. The current practice in diagnostic testing for thyroid tumors also is examined.
Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Jennifer L
JL
Hunt
D006801:Humans; D009154:Mutation; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000235:genetics*
D011518:Proto-Oncogene Proteins; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases