[Expression of oncogene C-jun in the cells of rat nasal mucosa and relevance with rhinorrhea].
OBJECTIVE
To study the expression of oncogene C-jun in rat nasal mucosa with allergic rhinitis and the relevance with rhinorrhea.


METHODS
By using EA to make animal model of allergic rhinitis successfully; the amount of rhinorrhea was calculated at 30 min. 4 h, 8 h. Immunohistochemical technique, computer image analysis technique and histologic examination were used to investigated the expression of C-jun in rat nasal mucosa at the same time. The relevance between them was used explored.


RESULTS
There was a lot of C-jun protein at 30 min. The difference of C-jun between 30 min group and control group was significant (P < 0.01) and the relevant coefficient was r = 0.784 (P < 0.05). The C-jun protein decreased at 4 h, but there was still significant difference (P < 0.05) and r = 0.626 (P < 0.05). The C-jun was as same as control group at 8 h, There was no difference between them.


CONCLUSIONS
The expression of oncogene C-jun in inflammatory cells may be a marker in early stage of activation of inflammatory cells, and related to the producing and secreting of cytokines and inflammatory mediators in inflammatory cells of allergic rhinitis.
Wang
Guanghui
G
Department of Otolaryngology, Huaxi Hospital, Sichuan University, Chengdu 610044.
Mou
Hong
H
Ren
Zhengxin
Z
Liang
Chuanyu
C
Zhang
Qinxiu
Q
D000818:Animals; D002559:Cerebrospinal Fluid Rhinorrhea / Q000150:complications; D009297:Nasal Mucosa / Q000378:metabolism / Q000473:pathology*; D016755:Proto-Oncogene Proteins c-jun / Q000096:biosynthesis*; D051381:Rats; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism / Q000473:pathology*
D016755:Proto-Oncogene Proteins c-jun