Proteome analysis of oral pathogens.
The oral environment contains diverse communities of micro-organisms including bacteria, fungi, protozoa, and viruses. Studies of oral ecology have led to an appreciation of the complexity of the interactions that oral micro-organisms have with the host in both health and disease. Despite this, diseases such as dental caries and periodontal diseases are still worldwide human ailments, resulting in a high level of morbidity and an economic burden to society. Proteomics offers a new approach to the understanding of holistic changes occurring as oral micro-organisms adapt to environmental change within their habitats in the mouth.
Macarthur
D J
DJ
Institute of Dental Research, Westmead Centre for Oral Health, PO Box 533, Wentworthville, NSW 2145, Australia.
Jacques
N A
NA
D000818:Animals; D001426:Bacterial Proteins / Q000032:analysis*; D002176:Candida albicans / Q000737:chemistry*; D002180:Candidiasis, Oral / Q000382:microbiology; D003731:Dental Caries / Q000382:microbiology; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D010518:Periodontitis / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000737:chemistry*; D020543:Proteome / Q000737:chemistry; D040901:Proteomics / Q000379:methods*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013295:Streptococcus mutans / Q000737:chemistry*; D013298:Streptococcus sanguis / Q000737:chemistry
D001426:Bacterial Proteins; D020543:Proteome