Chromophobe renal cell carcinoma with sarcomatoid transformation.
We present a rare case of a chromophobe renal cell carcinoma that progressed to a high-grade spindle cell sarcoma. The tumor affected a 50-year-old man who had presented with right upper quadrant discomfort and hematuria and subsequently underwent a right radical nephrectomy. Microscopically, the tumor was composed of two distinct components, a chromophobe renal cell carcinoma and a sarcomatoid component. The sarcomatoid component had exhibited aggressive behavior by spreading to a regional lymph node. This case report shows that chromophobe carcinoma can develop a sarcomatoid transformation with a high propensity for invasive growth and metastasis.
Department of Pathology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.
Neil A
NA
Abrahams
Alberto G
AG
Ayala
Bogdan
B
Czerniak
D002292:Carcinoma, Renal Cell / Q000556:secondary* / Q000601:surgery; D002471:Cell Transformation, Neoplastic; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D012509:Sarcoma / Q000556:secondary* / Q000601:surgery; D016896:Treatment Outcome