Bridging a patient with acute liver failure to liver transplantation by the AMC-bioartificial liver.
Recently a phase I clinical trial has been started in Italy to bridge patients with acute liver failure (ALF) to orthotopic liver transplantation (OLT) by the AMC-bioartificial liver (AMC-BAL). The AMC-BAL is charged with 10 x 10(9) viable primary porcine hepatocytes isolated from a specified pathogen-free (SPF) pig. Here we report a patient with ALF due to acute HBV infection. This patient was treated for 35 h by two AMC-BAL treatments and was bridged to OLT. There was improvement of biochemical and clinical parameters during the treatment. No severe adverse events were observed during treatment and follow-up of 15 months after hospital discharge. Possible porcine endogenous retrovirus (PERV) activity could not be detected in the patient's blood or blood cells up to 12 months after treatment.
Surgical Laboratory (IWO-I), Department of Surgery, Academic Medical Center, University of Amsterdam, The Netherlands. m.p.vandekerkhove@amc.uva.nl
Maarten-Paul
MP
van de Kerkhove
Ernesto
E
Di Florio
Vincenzo
V
Scuderi
Antonio
A
Mancini
Antonello
A
Belli
Adele
A
Bracco
Daniela
D
Scala
Simona
S
Scala
Laura
L
Zeuli
Giuseppe
G
Di Nicuolo
Pietro
P
Amoroso
Fulvio
F
Calise
Robert A F M
RA
Chamuleau
D000328:Adult; D000641:Ammonia / Q000097:blood; D000818:Animals; D001663:Bilirubin / Q000097:blood; D005260:Female; D006509:Hepatitis B / Q000601:surgery*; D022781:Hepatocytes / Q000166:cytology / Q000276:immunology / Q000637:transplantation; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D017114:Liver Failure, Acute / Q000601:surgery*; D016031:Liver Transplantation / Q000295:instrumentation* / Q000379:methods*; D019164:Liver, Artificial / Q000592:standards / Q000639:trends*; D011516:Prothrombin / Q000378:metabolism; D012190:Retroviridae / Q000276:immunology; D013047:Specific Pathogen-Free Organisms; D034421:Sus scrofa; D000637:Transaminases / Q000097:blood; D016896:Treatment Outcome
D019344:Lactic Acid; D000641:Ammonia; D011516:Prothrombin; D000637:Transaminases; D001663:Bilirubin