[Aptameric DNA--a new type of thrombin inhibitor].
The formation of complexes between various thrombin preparations and a 30-mer aptamer DNA was comparatively studied, and a correlation between the complex formation and the fibrinogen-hydrolyzing activity of thrombin was found. The aptamer DNA was shown to inhibit the fibrin formation from fibrinogen.
Belozersky Institute of Physicochemical Biology, Moscow State University, Vorob'evy gory, Moscow, 119992 Russia. spiridon@genebee.msu.su
V A
VA
Spiridonova
E V
EV
Rog
T N
TN
Dugina
S M
SM
Strukova
A M
AM
Kopylov
D000991:Antithrombins / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry / Q000494:pharmacology*; D005340:Fibrinogen / Q000378:metabolism; D006868:Hydrolysis; D008958:Models, Molecular; D011487:Protein Conformation
D000991:Antithrombins; D005340:Fibrinogen; D004247:DNA