New silica-immobilized chiral amino alcohol for the enantioselective addition of diethylzinc to benzaldehyde.
[reaction: see text] A readily available chiral amino alcohol has been immobilized on silica by sol-gel synthesis and grafting. The solid prepared according to the latter method led to the best enantioselectivity (77% ee) described for the asymmetric addition of diethylzinc to benzaldehyde using inorganic solids.
Fraile
José M
JM
Departamento de Química Orgánica, Instituto de Ciencia de Materiales de Aragón, Facultad de Ciencias, Universidad de Zaragoza-CSIC, E-50009 Zaragoza, Spain.
Mayoral
José A
JA
Serrano
Jorge
J
Pericàs
Miquel A
MA
Solà
Lluís
L
Castellnou
David
D