Starvation survival response of Mycobacterium tuberculosis.
The ability of Mycobacterium tuberculosis auxotrophs to survive long-term starvation was measured. Tryptophan and histidine auxotrophs did not survive single-amino-acid starvation, whereas a proline auxotroph did. All three auxotrophs survived complete starvation. THP-1 cells were also able to restrict the growth of the tryptophan and histidine auxotrophs.
Parish
Tanya
T
Department of Medical Microbiology, Barts and the London, Queen Mary's School of Medicine and Dentistry, London E1 2AD, United Kingdom. t.parish@qmul.ac.uk
D015169:Colony Count, Microbial; D003470:Culture Media; D018869:Heat-Shock Response; D006639:Histidine / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000254:growth & development* / Q000502:physiology*; D011392:Proline / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism
D003470:Culture Media; D006639:Histidine; D014364:Tryptophan; D011392:Proline