[A case of advanced gastric cancer treated with weekly paclitaxel with measurement of paclitaxel concentrations in blood and ascites].
We measured paclitaxel (PTX) concentrations in blood and ascites in a patient with advanced gastric cancer treated with weekly paclitaxel (80 mg/m2). After 180 minutes from infusion of PTX, the concentration of PTX in ascites was 13 ng/ml, which was more than the reported cytotoxic dose of PTX (8.5 ng/ml). The concentration of PTX in ascites was retained, and rose rather slowly during a 24-hour period. The patient died soon after the measurement, meaning this measurement was taken at a time when the antitumor effect was ineffective and under poor general conditions. The result suggested, however, that the desired concentration of PTX in ascites can be obtained with a smaller dose of PTX in a regimen of weekly PTX.
Dept. of Surgery, Aichi Hospital.
Taiki
T
Kojima
Takanori
T
Matsui
Takanori
T
Uemura
Yasunobu
Y
Fujimitsu
Jyunji
J
Kato
Hiroshi
H
Kojima
D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001201:Ascites / Q000378:metabolism*; D004334:Drug Administration Schedule; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013274:Stomach Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel