Analysis of CD4+CD25+ cell population in the thymus from myasthenia gravis patients.
The present study is aimed at exploring the regulatory CD4(+)CD25(+) T cells in the thymus from myasthenia gravis (MG) patients. In early-onset MG, the thymus is hyperplastic and contains autoreactive activated T cells. Preliminary studies indicate that these CD4(+)CD25(+) cells include activated autoreactive T cells. Studies to characterize the phenotype and suppressive capacity of these cells will be discussed.
CNRS UMR 8078, IPSC, Université Paris XI, Hôpital Marie Lannelongue, Le Plessis-Robinson, France. anna.balandina@ccml.u-psud.fr
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A
Balandina
A
A
Saoudi
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P
Dartevelle
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S
Berrih-Aknin
D015704:CD4 Antigens / Q000378:metabolism*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D016827:CD8 Antigens / Q000276:immunology; D005434:Flow Cytometry / Q000295:instrumentation / Q000379:methods; D006801:Humans; D009157:Myasthenia Gravis / Q000378:metabolism / Q000473:pathology*; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D013934:Thymectomy; D013950:Thymus Gland / Q000473:pathology*
D015704:CD4 Antigens; D016827:CD8 Antigens; D015375:Receptors, Interleukin-2