Decreased L5 spinal nerve ligation nociceptive behavior following L4 spinal nerve transection.
This study used the escape/avoidance paradigm to explore the role of the L4 spinal nerve in L5 ligation nociception. Unlike L5-ligated controls, L5-ligated/L4-transected animals had normal mechanical withdrawal threshold and did not escape/avoid mechanical stimulation of the afflicted paw. The result from the escape/avoidance paradigm, which does not rely on a reflexive withdrawal response, directly supports the hypothesis that the L4 spinal nerve contributes to L5 ligation neuropathic pain.
Department of Psychology, University of Texas at Arlington, Box 19528, Arlington, TX 76019, USA.
Stacey C
SC
LaGraize
Jasenka
J
Borzan
Perry N
PN
Fuchs
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D008026:Ligation; D008297:Male; D010146:Pain / Q000523:psychology*; D017288:Pain Threshold / Q000502:physiology; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013127:Spinal Nerves / Q000502:physiology*