[C-fos topography in neocortical neurons of mice during fear conditioning].
Patterns of expression of c-Fos transcription factor in the motor (M1 and M2) and cingulate cortex (dorsal part, Cg1, RSA, and ventral part, PrL, Cg2, RSG) were analyzed after fear conditioning in 129 sv mice. Mice were exposed to the context and tone followed by electric footshock (footshock group, FG) or to context only (context group, CG). Control mice were taken from a home cage (HG). In the rostral part of the motor cortex the number of c-Fos-labeled neurons was the same in all the groups. It was increased in the rostrocaudal direction in FG and CG but not in HG mice. A higher level of c-Fos expression in FG (as compared to CG) was observed in the medial parts of the M1, in the caudal and medial parts of the M2, and in the dorsal but not ventral regions of the cingulate cortex. Thus, the rostrocaudal gradient of c-Fos expression was originally demonstrated in motor cortex of mice during learning.
Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow.
S V
SV
Zvorykina
K V
KV
Anokhin
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003213:Conditioning, Psychological / Q000502:physiology*; D005239:Fear; D007103:Immobilization / Q000502:physiology*; D007858:Learning; D051379:Mice; D009474:Neurons / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D012018:Reflex / Q000502:physiology*
D016760:Proto-Oncogene Proteins c-fos