Growth hormone molecular heterogeneity and exercise.
There are more than 100 molecular isoforms of circulating growth hormone (GH), but the traditional measurement approach in the exercise literature has only focused on the main isoform (i.e., 22 kDa). New assay methodologies now can assess various GH isoforms. The current data suggest that exercise results in the preferential release of GH isoforms with extended half-lives, thereby sustaining biological actions.
Nindl
Bradley C
BC
Military Performance Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA 01760, USA. Bradley.nindl@na.amedd.army.mil
Kraemer
William J
WJ
Marx
James O
JO
Tuckow
Alexander P
AP
Hymer
Wesley C
WC
D015444:Exercise / Q000502:physiology*; D014644:Genetic Variation / Q000502:physiology*; D019382:Human Growth Hormone / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007118:Immunoassay / Q000379:methods; D020033:Protein Isoforms / Q000378:metabolism
D020033:Protein Isoforms; D019382:Human Growth Hormone