Fatal squamous cell carcinoma arising from transplant-associated porokeratosis.
Porokeratosis is a disorder of epidermal keratinization characterized by variably sized plaques with central depression and a well-demarcated keratotic border. Associations of porokeratosis with immunosuppression and of porokeratosis with malignancy have been observed. The authors report a case of fatal metastatic squamous cell carcinoma arising from porokeratosis in an immunosuppressed patient.
Silver
Shane G
SG
Department of Pathology, University of British Columbia.
Crawford
Richard I
RI
D002294:Carcinoma, Squamous Cell / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation / Q000009:adverse effects; D008875:Middle Aged; D017499:Porokeratosis / Q000150:complications* / Q000276:immunology; D012878:Skin Neoplasms / Q000209:etiology*