Spectrophotometric study on the stability of dopamine and the determination of its acidity constants.
The interest in determining the acidity constants of the catecholamines stems from the fact that they play rather an important biological role. The present work reveals the effect of different parameters such as oxygen, light, analysis time and pH on the dopamine oxidation process, where oxygen has an effect on the dopamine oxidation of 40% and up to 20% is attributed to exposure to light as a function of the pH. The application of adequate control on the said parameters (which ensured stability of the dopamine) facilitated the determination of the corresponding three acidity constants, 9.046+/-0.147, 10.579+/-0.148 and 12.071+/-0.069.
Departamento de Qui;mica, Universidad Autónoma Metropolitana (Iztapalapa), Av. San Rafael Atlixco #186, Col. Vicentina, C.P. 09340, México, D.F., Mexico.
A E
AE
Sánchez-Rivera
S
S
Corona-Avendaño
G
G
Alarcón-Angeles
A
A
Rojas-Hernández
M T
MT
Ramírez-Silva
M A
MA
Romero-Romo
D004298:Dopamine / Q000737:chemistry*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010084:Oxidation-Reduction; D013053:Spectrophotometry / Q000379:methods
D004298:Dopamine