Genome-wide scan for linkage in finnish hereditary prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26.
BACKGROUND
In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome-wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families.


METHODS
Altogether 87 DNA samples were genotyped from 13 families. Logarithm-of-odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown.


RESULTS
The highest LOD scores in the affected-only analyses were found at 11q14, where the two-point LOD score was 2.97 (theta = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non-parametric-linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25-26, with a two-point LOD score of 2.57 (theta = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02).


CONCLUSIONS
The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.
Laboratory of Cancer Genetics, University of Tampere and Tampere University Hospital, Tampere, Finland. Johanna.schleutker@uta.fi
Johanna
J
Schleutker
Agnes B
AB
Baffoe-Bonnie
Elizabeth
E
Gillanders
Tommi
T
Kainu
Mary-Pat
MP
Jones
Diana
D
Freas-Lutz
Carol
C
Markey
Derek
D
Gildea
Erica
E
Riedesel
Julie
J
Albertus
Kenneth D
KD
Gibbs
Mika
M
Matikainen
Pasi A
PA
Koivisto
Teuvo
T
Tammela
Joan E
JE
Bailey-Wilson
Jeffrey M
JM
Trent
Olli-P
OP
Kallioniemi
D000368:Aged; D000369:Aged, 80 and over; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D004273:DNA, Neoplasm / Q000737:chemistry / Q000235:genetics; D005190:Family; D005260:Female; D005387:Finland; D008040:Genetic Linkage / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011471:Prostatic Neoplasms / Q000235:genetics*; D017422:Sequence Analysis, DNA; D018709:Statistics, Nonparametric; D013274:Stomach Neoplasms / Q000235:genetics
D004273:DNA, Neoplasm