Neuropsychological dysfunction in patients with end-stage pulmonary disease: lung transplant evaluation.
There has been a relative absence of studies that have examined the neuropsychological profiles of potential lung transplant candidates. Neuropsychological data are presented for 134 patients with end-stage pulmonary disease who were being evaluated as potential candidates for lung transplantation. Neuropsychological test results indicated that a significantly greater proportion of the patients exhibited impaired performances on a number of Selective Reminding Test (SRT) tasks as compared to the expected population frequency distributions for these measures. The highest frequencies of impairment were observed on the SRT's Immediate Free Recall (46.43%), Long-term Retrieval (41.67%), and Consistent Long-term Retrieval (51.19%) variables. On the Minnesota Multiphasic Personality Inventory-2 (MMPI-2)/Minnesota Multiphasic Personality Inventory-Adolescent (MMPI-A), patients' mean clinical profile revealed elevations on Scales 1 (Hypochondriasis) and 3 (Conversion Hysteria). This profile indicated that they were experiencing an array of symptomatology ranging from somatic complaints to lethargy and fatigue, and that they may have been functioning at a reduced level of efficiency. Findings are discussed in light of patients' end-stage pulmonary disease and factors possibly contributing to their neuropsychological test performances. Implications for clinical practice and future research are also provided.
Virginia Polytechnic Institute and State University, Blacksburg, VA, USA.
W David
WD
Crews
Angela L
AL
Jefferson
Donna K
DK
Broshek
Robert D
RD
Rhodes
John
J
Williamson
Amy M
AM
Brazil
Jeffrey T
JT
Barth
Mark K
MK
Robbins
D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000150:complications* / Q000523:psychology* / Q000601:surgery; D016040:Lung Transplantation / Q000523:psychology*; D008297:Male; D001523:Mental Disorders / Q000150:complications* / Q000523:psychology* / Q000601:surgery; D008875:Middle Aged; D009422:Nervous System Diseases / Q000150:complications* / Q000523:psychology* / Q000601:surgery; D009483:Neuropsychological Tests; D012720:Severity of Illness Index