Rheumatoid arthritis: targeting the proliferative fibroblasts.
Our flexible joints are synovial joints composed of bone, hyaline cartilage, synovial membrane, ligaments and tendons. Rheumatoid arthritis is a disease that affects multiple synovial joints and involves inflammation of the synovial membrane, often resulting in loss of function due to erosion of bone and cartilage. Inflammation is accompanied by an influx of immune-competent cells and by aberrant proliferation of resident fibroblast-like synoviocytes. Accretion of fibroblasts directly contributes to joint destruction, through enhanced production of matrix-degrading enzymes, and indirectly, through excessive release of cytokines that boost the immune system. Targeting the proliferative fibroblast could facilitate regeneration of synovial joints.
Kramer
Ijsbrand
I
Section of Cellular and Molecular Biology, European Institute of Chemistry and Biology, Bat B2, University of Bordeaux 1, 33405 Talence, France.
Wibulswas
Auragun
A
Croft
Daniel
D
Genot
Elisabeth
E
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology*; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D005109:Extracellular Matrix / Q000201:enzymology / Q000276:immunology; D005347:Fibroblasts / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D020782:Matrix Metalloproteinases / Q000276:immunology / Q000378:metabolism; D013583:Synovial Membrane / Q000201:enzymology / Q000276:immunology / Q000503:physiopathology*
D000893:Anti-Inflammatory Agents; D016207:Cytokines; D020782:Matrix Metalloproteinases