Starvation survival response of Mycobacterium tuberculosis.
The ability of Mycobacterium tuberculosis auxotrophs to survive long-term starvation was measured. Tryptophan and histidine auxotrophs did not survive single-amino-acid starvation, whereas a proline auxotroph did. All three auxotrophs survived complete starvation. THP-1 cells were also able to restrict the growth of the tryptophan and histidine auxotrophs.
Department of Medical Microbiology, Barts and the London, Queen Mary's School of Medicine and Dentistry, London E1 2AD, United Kingdom. t.parish@qmul.ac.uk
Tanya
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Parish
D015169:Colony Count, Microbial; D003470:Culture Media; D018869:Heat-Shock Response; D006639:Histidine / Q000378:metabolism; D009169:Mycobacterium tuberculosis / Q000254:growth & development* / Q000502:physiology*; D011392:Proline / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism
D003470:Culture Media; D006639:Histidine; D014364:Tryptophan; D011392:Proline