Diffuse large B-cell lymphoma with occult marrow involvement and a novel t(9;10)(q32;q22).
A 33-year-old man was found to have stage IV diffuse large cell lymphoma with visceral, cutaneous, and central nervous system involvement. Although examination of the posttreatment bone marrow failed to show morphologic evidence of lymphoma involvement, cytogenetic study of the marrow mononuclear cells showed the presence of a clonal abnormality t(9;10)(q32;q22), a hitherto undescribed chromosomal abnormality in diffuse large B-cell lymphoma.
Department of Pathology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong SAR, China. kfwong@ha.org.hk
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D000328:Adult; D001853:Bone Marrow / Q000473:pathology*; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D016393:Lymphoma, B-Cell / Q000235:genetics* / Q000473:pathology*; D008297:Male; D016133:Polymerase Chain Reaction; D014178:Translocation, Genetic