On the trail of an elusive flux sensor.
The hexokinase PII isozyme has been implicated as an essential component of multiple glucose sensing pathways in the yeast Saccharomyces cerevisiae. Several lines of evidence suggest that the flux through this enzymatic step, but not the levels of substrates, cofactors or products, is the critical process detected by downstream sensing machinery. In spite of intensive research efforts, how the activity of this enzyme is translated into a quantitative signal remains an unresolved question.
Department of Viticulture and Enology, University of California, Davis, CA 95616-8749, USA. lfbisson@ucdavis.ca
Linda F
LF
Bisson
Viyada
V
Kunathigan
D015966:Gene Expression Regulation, Fungal; D005947:Glucose / Q000378:metabolism / Q000502:physiology; D006593:Hexokinase / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000201:enzymology*; D015398:Signal Transduction / Q000502:physiology*
D006593:Hexokinase; D005947:Glucose