[Preparation of biologically transformed raw material from woolly foxglove Digitalis lanata Ehrh and isolation of digoxin from it].
A biotechnological approach is proposed for conservation of a terraneous part of woolly foxglove under anaerobic conditions with a subsequent air-sun drying of the biologically transformed raw material. During the conservation primary foxglove glycosides completely convert to secondary ones which do not transform further. A simple method is described for preparation from the transformed raw material of an enriched glycoside fraction with the yield of 3.6% and for isolation from this fraction of highly purified digoxin with the yield of 0.06% of the starting raw material, and the other secondary glycosides can be also isolated.
Fonin
V S
VS
All-Russian Institute of Medicinal and Aromatic Plants, Russian Academy of Agricultural Sciences, Moscow 117216, Russia.
Khorlin
A Ia
AIa
D000388:Air; D000693:Anaerobiosis; D002845:Chromatography; D004070:Digitalis / Q000378:metabolism*; D004077:Digoxin / Q000032:analysis / Q000302:isolation & purification*; D006027:Glycosides / Q000737:chemistry / Q000378:metabolism; D035261:Plant Components, Aerial / Q000378:metabolism; D010936:Plant Extracts / Q000378:metabolism; D010946:Plants, Medicinal / Q000378:metabolism; D012426:Russia; D016082:Solar System
D006027:Glycosides; D010936:Plant Extracts; D004077:Digoxin