Auditory processing in patients with Charcot-Marie-Tooth disease type 1A.
OBJECTIVE
It is unclear whether Charcot-Marie-Tooth (CMT) disease, type 1A, causes auditory processing disorders. Therefore, auditory processing abilities were investigated in five CMT1A patients with normal hearing.


BACKGROUND
Previous studies have failed to separate peripheral from central auditory processing disorders.


METHODS
Five genetically confirmed CMT1A cases in patients with normal hearing underwent behavioral and objective testing. Pure tone audiometry, speech audiometry, and OAE assessment were followed-up by an auditory processing test battery comprising sentences-in-noise test, pattern recognition tests, words-in-noise test, dichotic digit test, filtered speech test, binaural fusion test, and categorical speech perception test. Subsequently, ABR and ERP measurements were conducted.


RESULTS
Either the behavioral or objective test scores of 4 out of the 5 CMT1A patients did not differ significantly from those of subjects with normal hearing. Significantly lower scores of one patient on auditory processing tests and ABR measurements could be ascribed to subnormal hearing.


CONCLUSIONS
The authors conclude that CMT1A patients with normal peripheral hearing have auditory processing abilities that were not indicative for an auditory processing disorder. Furthermore, the presence of a peripheral hearing loss complicates the interpretation of auditory processing abilities.
University Medical Center Nijmegen, Department of Otorhinolaryngology, Nijmegen, The Netherlands. k.neijenhuis@kno.umcn.nl
Karin
K
Neijenhuis
Andy
A
Beynon
Ad
A
Snik
Baziel
B
van Engelen
Paul
P
van den Broek
D000161:Acoustic Stimulation; D000328:Adult; D001301:Audiometry, Pure-Tone; D001302:Audiometry, Speech; D001307:Auditory Perception; D001308:Auditory Perceptual Disorders / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology*; D002607:Charcot-Marie-Tooth Disease / Q000150:complications* / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous; D011930:Reaction Time