[Antihypoxic effect of vitamin E and its derivative in rats under modeling of hypoxic conditions of different origin].
The increase of ubiquinone content in myocardial mitochondria and succinateubiquinone reductase activity in rat blood leucocytes under hypoxic hypoxia and acute microfocal myocardial damage [table: see text] have been shown. At the same time the succinateubiquinone reductase activity of rat myocardial mitochondria do not change substantially. We simultaneously observe the dramatic drop in NADH-ubiquinone reductase activity under experimental myocarditis. This fact demonstrates higher stability of succinateubiquinone reductase system and differences in metabolical processes under hypoxic conditions of different origin. All vitamin E derivatives studied demonstrate substantial antihypoxic activity, which is connected with increased animals' survivability, ubiquinone content in myocardial mitochondria and stabilization and leveling of succinateubiquinone reducatse activity in rat blood leucocytes. alpha-Tocopherolacetate with shortened to six carbon atoms side chain is the most effective in this respect. We discuss possible mechanisms for the realization of vitamin E and its active derivative's antihypoxic effect.
Zvaĭd
F R
FR
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv.
Donchenko
G V
GV
Kuz'menko
I V
IV
D000818:Animals; D004579:Electron Transport; D004795:Enzyme Stability; D004837:Epinephrine / Q000494:pharmacology; D000860:Hypoxia / Q000378:metabolism*; D007962:Leukocytes / Q000201:enzymology / Q000378:metabolism; D008929:Mitochondria, Heart / Q000201:enzymology / Q000378:metabolism; D009205:Myocarditis / Q000139:chemically induced / Q000378:metabolism; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014451:Ubiquinone / Q000187:drug effects / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*
D014451:Ubiquinone; D014810:Vitamin E; D013385:Succinate Dehydrogenase; D016660:NAD(P)H Dehydrogenase (Quinone); D004837:Epinephrine