Prevalence and clinicopathological characteristics of islet amyloid in chinese patients with type 2 diabetes.
Islet amyloid has been suggested to be an important link between insulin resistance and beta-cell dysfunction in type 2 diabetes. To investigate the prevalence and clinicopathological characteristics of islet amyloid, we examined consecutive autopsies of 235 Chinese patients with type 2 diabetes and 533 nondiabetic subjects. Islet amyloid deposits were identified using Congo red staining and quantitated by image analysis. We found that 3.0% of the nondiabetic subjects versus 39.6% of the diabetic patients displayed islet amyloid (P < 0.001). In diabetic patients, the amyloid deposits occupied a mean islet area of 36.2%, which was positively associated with BMI, blood pressure, and glycemic control. Pancreatic fibrosis and fat infiltration were more frequently found in diabetic patients with islet amyloid than those without islet amyloid, whereas pancreatic arteriosclerosis was identified in all diabetic patients. These findings suggest that islet amyloid deposits reflect greater insulin resistance and islet failure in a subgroup of type 2 diabetic patients. Islet failure may also have been exacerbated by fat infiltration, fibrosis, and arteriosclerosis. Optimal blood pressure and metabolic control may reduce these pathological changes and help preserve islet cell mass.
Zhao
Hai-Lu
HL
Department of Medicine and Therapeutics, The Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong SAR, China. zhaohailu@cuhk.edu.hk
Lai
Fernand M M
FM
Tong
Peter C Y
PC
Zhong
Ding-Rong
DR
Yang
Di
D
Tomlinson
Brian
B
Chan
Juliana C N
JC
D000328:Adult; D000368:Aged; D000682:Amyloid / Q000032:analysis*; D001161:Arteriosclerosis / Q000473:pathology; D001344:Autopsy; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D015992:Body Mass Index; D002681:China; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006723:Hong Kong; D006801:Humans; D058228:Islet Amyloid Polypeptide; D007515:Islets of Langerhans / Q000473:pathology*; D008297:Male; D008499:Medical Records; D010179:Pancreas / Q000098:blood supply; D012016:Reference Values; D012189:Retrospective Studies
D000682:Amyloid; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D058228:Islet Amyloid Polypeptide; D002784:Cholesterol