Pathogenesis of and immunity to a new influenza A (H5N1) virus isolated from duck meat.
The outbreak of avian influenza H5N1 in Hong Kong in 1997 raised concerns about the potential for the H5 subtype to cause a human pandemic. In 2001 a new H5N1 virus, A/Duck Meat/Anyang/AVL-1/2001 (A/Dkmt), was isolated from imported duck meat in Korea. The pathogenesis of this virus was investigated in mice. A/Dkmt virus had low infectivity but was lethal for mice at high doses, and at lethal doses, the virus replicated in the brains of infected mice. A/Dkmt virus cross-reacted poorly with ferret antisera raised against human H5N1 viruses, but prior infection with A/Dkmt virus protected mice from death after secondary infection with human H5N1 virus.
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Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, N.E., Atlanta, GA 30333, USA.
Cho
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Hall
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Rowe
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Mo
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Sung
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Kim
W J
WJ
Kang
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Cox
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N
Klimov
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A
Katz
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JM
D000818:Animals; D001835:Body Weight; D003428:Cross Infection / Q000517:prevention & control; D004196:Disease Outbreaks / Q000662:veterinary; D004372:Ducks / Q000821:virology*; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype; D009980:Influenza A virus / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*; D005585:Influenza in Birds / Q000503:physiopathology*; D008460:Meat / Q000821:virology*; D051379:Mice; D008807:Mice, Inbred BALB C; D013997:Time Factors; D014779:Virus Replication / Q000502:physiology*; D015047:Zoonoses / Q000453:epidemiology