Glucose and mannitol diffusion in human dura mater.
An in vitro experimental study of the control of the human dura mater optical properties at administration of aqueous solutions of glucose and mannitol has been presented. The significant increase of the dura mater optical transmittance under action of immersion liquids has been demonstrated. Diffusion coefficients of glucose and mannitol in the human dura mater tissue at 20 degrees C have been estimated as (1.63 +/- 0.29) x 10(-6)cm(2)/s and as (1.31 +/- 0.41) x 10(-6) cm(2)/s, respectively. Experiments show that administration of immersion liquids allows for the effective control of tissue optical characteristics that make dura mater more transparent, thereby increasing the ability of light penetration through the tissue.
Department of Optics, Saratov State University, Saratov, Russia. bash@optics.sgu.ru
Alexey N
AN
Bashkatov
Elina A
EA
Genina
Yuri P
YP
Sinichkin
Vyacheslav I
VI
Kochubey
Nina A
NA
Lakodina
Valery V
VV
Tuchin
D000327:Adsorption; D000465:Algorithms; D046508:Culture Techniques; D004058:Diffusion; D004388:Dura Mater / Q000378:metabolism*; D005947:Glucose / Q000493:pharmacokinetics*; D006801:Humans; D008353:Mannitol / Q000493:pharmacokinetics*; D008954:Models, Biological; D009995:Osmosis / Q000502:physiology; D012031:Refractometry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis / Q000379:methods*; D041622:Tomography, Optical / Q000379:methods*
D008353:Mannitol; D005947:Glucose