Expression of LRP--lung resistance-related protein in the normal colorectal mucosa and in colorectal carcinoma.
Expression of LRP--lung resistance-related protein was analyzed by immunohistochemical staining with monoclonal antibody LRP-56 in 30 specimens (10 from normal colorectal tissue and 20 from colorectal carcinoma). All normal tissue samples were LRP positive. Strong LRP staining was seen in the surface epithelium and upper parts of the crypts. Similarly, colorectal carcinomas demonstrated strong staining for LRP/MVP. Staining pattern of cytoplasm of carcinoma cells was the same as in the normal mucosa. The overexpression of LRP in the colorectal carcinoma may play a role in the process of carcinogenesis or be a marker of an aggressive phenotype. It seems, the high value of LRP is a predictor of response to chemotherapy and prognoses in various tumor types. (Fig. 7, Ref: 18.).
Institute of Anatomy, Faculty of Medicine, Safarikiensis University, Kosice, Slovakia. rybars@pobox.sk
S
S
Rybarova
A
A
Boor
I
I
Jurkovic
P
P
Kocan
D002277:Carcinoma / Q000737:chemistry* / Q000188:drug therapy; D015179:Colorectal Neoplasms / Q000737:chemistry* / Q000188:drug therapy; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000737:chemistry*; D009363:Neoplasm Proteins / Q000032:analysis*; D020394:Vault Ribonucleoprotein Particles; D000099187:Major Vault Protein
D009363:Neoplasm Proteins; D020394:Vault Ribonucleoprotein Particles; D000099187:Major Vault Protein