Acivicin induce filamentous growth of Saccharomyces cerevisiae.
The antibiotic acivicin is a known inhibitor of gamma-glutamyl transpeptidase (gammaGTP). We found that acivicin can induce filamentous growth in both diploid and haploid cells of Saccharomyces cerevisiae. This phenomenon is not related to the inhibition of gammaGTP or interference in glutathione metabolism. Interestingly, yeasts used in the brewing industry are more sensitive to acivicin, suggesting that this dimorphological differentiation may be related to some characteristics of these particular strains.
Miyake
Tsuyoshi
T
Industrial Technology Center of Okayama Prefecture, Haga, Okayama, Japan. tsuyoshi_miyake@pref.okayama.jp
Sammoto
Hiroyuki
H
Ono
Bun-ichiro
B
D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007555:Isoxazoles / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000254:growth & development; D005723:gamma-Glutamyltransferase / Q000037:antagonists & inhibitors
D007555:Isoxazoles; D005723:gamma-Glutamyltransferase; C006303:acivicin