Darier's disease associated with an underlying neoplasm in combination with a nodular fibroproliferative disease.
Darier's disease is an autosomal dominant disease that typically arises during the first or second decades of life. It involves the abnormal keratinization of the epidermis, mucosa, and nails. We describe a 74-year-old man with metastatic carcinoma in whom fibroproliferative disease and an acquired variant of Darier's disease developed, both of which may have been paraneoplastic processes.
Department of Dermatology, The Hospital of the University of Pennsylvania, Philadelphia 19104, USA.
Kathryn L
KL
Dortzbach
John T
JT
Seykora
Victoria P
VP
Werth
D000230:Adenocarcinoma / Q000150:complications / Q000175:diagnosis* / Q000556:secondary; D000368:Aged; D001415:Back; D007644:Darier Disease / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D017495:Hyperpigmentation / Q000209:etiology / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D009262:Nails; D009382:Neoplasms, Unknown Primary / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D013405:Suicide