[Impact of short-term neoadjuvant hormonal treatment on neuroendocrine differentiation in prostate carcinoma].
OBJECTIVE
To study the impact of short-term neoadjuvant hormonal treatment on neuroendocrine (NE) differentiation and the relation of NE differentiation and tumor regression.


METHODS
The radical prostatectomy specimens and the biopsy specimens of the same 18 patients with prostate cancer were compared. The effect of hormonal treatment on NE-differentiation was evaluated by specific antibodies against chromogranin A (ChA) and serotonin (5-HT).


RESULTS
The ChA-positive cell count was 3.2 x 10(-5)/microm(2) [(0-5.7) x 10(-5)/microm(2)] before hormonal treatment and 2.3 x 10(-5) microm(2)[(0-6.6) x 10(-5)/microm(2)] afterward (P > 0.05). For the proportion of NE-positive tumor, it was 7.0% (0%-14.9%) and 4.5% (0%-13.1%) (P > 0.05). No correlation existed between NE-differentiation and the neoadjuvant hormonal treatment. The NE cell density did not differ significantly between 12 non-/slightly regressive tumor foci and 6 highly regressive ones (P > 0.05).


CONCLUSIONS
Short-term neoadjuvant hormonal therapy does not induce clonal propagation of NE cells. The degree of tumor regression following short-term neoadjuvant hormonal therapy is not correlated with the NE differentiation.
Institute of Urology, First Hospital, Peking University, Beijing 100034, China.
Gui-zhong
GZ
Li
Li
L
Zeng
Jun
J
Zhang
Yi-ming
YM
Yuan
Xin-yu
XY
Yang
Jing-hua
JH
Wang
Yan-qun
YQ
Na
Ying-lu
YL
Guo
D000368:Aged; D000726:Androgen Antagonists / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009490:Neurosecretory Systems / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D012701:Serotonin / Q000032:analysis
D000726:Androgen Antagonists; D018931:Antineoplastic Agents, Hormonal; D053379:Chromogranin A; D002864:Chromogranins; D012701:Serotonin