Head-to-tail oxime cyclization of oligodeoxynucleotides for the efficient synthesis of circular DNA analogues.
A convenient strategy for the synthesis of the analogue of cyclic oligodeoxyribonucleotides is presented. The cyclization of the oligonucleotide was accomplished through intramolecular oxime bond formation between a 5'-oxyamine moiety and a 3'-aldehydic group.
Edupuganti
Om Prakash
OP
LEDSS, UMR CNRS 5616, ICMG FR2607, Université Joseph Fourier, BP 53, 38041 Grenoble 9, France. eric.defrancq@ujf-grenoble.fr
Defrancq
Eric
E
Dumy
Pascal
P
D000447:Aldehydes / Q000737:chemistry; D003500:Cyclization; D004270:DNA, Circular / Q000138:chemical synthesis*; D008956:Models, Chemical; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D010091:Oximes / Q000138:chemical synthesis*; D017421:Sequence Analysis
D000447:Aldehydes; D004270:DNA, Circular; D009838:Oligodeoxyribonucleotides; D010091:Oximes