Polymorphism in the hMSH2 gene (gIVS 12-6T-->C) and risk of non-Hodgkin lymphoma in a Japanese population.
We conducted a hospital-based prevalent case-control study in a Japanese population (cases=103, controls=487) to ascertain the previous report about the association between the polymorphism in exon 13 of the hMSH2 gene (gIVS 12-6T-->C) and the risk of non-Hodgkin lymphoma in an Ecuadorian population. When the TT genotype was defined as the reference, none of the CT genotypes (OR=1.52; 95% CI, 0.97-2.37), CC genotypes (OR=1.06, 95% CI, 0.44-2.54), or CT and CC genotypes combined together (OR=1.44, 95% CI, 0.94-2.23) demonstrated significant OR. Further investigations with sufficiently larger populations and in other ethnicities are required to verify this association.
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, 464-8681, Nagoya, Japan. a-hishi@med.nagoya-u.ac.jp
Asahi
A
Hishida
Keitaro
K
Matsuo
Nobuyuki
N
Hamajima
Hidemi
H
Ito
Michinori
M
Ogura
Yoshitoyo
Y
Kagami
Hirofumi
H
Taji
Yasuo
Y
Morishima
Nobuhiko
N
Emi
Kazuo
K
Tajima
D000251:Adenosine Triphosphatases / Q000235:genetics; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D017931:DNA Primers; D004260:DNA Repair / Q000235:genetics; D004268:DNA-Binding Proteins; D004484:Ecuador / Q000208:ethnology; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000235:genetics*; D051718:MutS Homolog 2 Protein; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D012016:Reference Values; D012307:Risk Factors
D017931:DNA Primers; D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D000251:Adenosine Triphosphatases; C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein