[The use of pre-differentiated mesenchymal bone marrow stem cells for treatment of deep burn wounds].
The opportunity of faster closing deep burn wounds by using fibroblast-like mesenchymal bone marrow stem cells (FMSC) and embryonic fibroblasts (EF) was investigated in rats. It was shown that FMSC as well as EF transplanted onto burn surfaces reduced the expression of cell infiltration but accelerated the formation of vessels de novo and granulation tissue in the wounds. These changes form the conditions for faster closing the burn wounds as compared to the control wounds (without cell transplantation). High rate of wound closing induced by FMSC and EF is thought to be caused by a long period (up to 30 days) of vital activity of the cells grafted on the burn surface. It was also found out that the rate of wound regeneration induced by FMSC was higher that that induced by EF.
Shumakov
V I
VI
Onishchenko
N A
NA
Rasulov
M F
MF
Krasheninnikov
M E
ME
Zaĭdenov
V A
VA
D000818:Animals; D001853:Bone Marrow / Q000196:embryology*; D002056:Burns / Q000601:surgery*; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D014184:Transplantation, Homologous