Iridoid glucosides from the flowers of Barleria lupulina.
A new iridoid diglucoside, lupulinoside, and eight known iridoid glucosides, acetylbarlerin, ipolamiidoside ( 3), 6-O-acetylshanzhiside methyl ester, barlerin, shanzhiside methyl ester, mussaenosidic acid, 8-O-acetylshanzhiside, and shanzhiside have been isolated from the flowers of Barleria lupulina. The structure of the new compound was established as 8-O-acetyl-2'- O-(beta-glucopyranosyl)mussaenoside by spectroscopic, especially 2D NMR, techniques. When tested for anti-herpes simplex type 1 activity, only compound 3 exhibited antiviral properties. None of the compounds showed cytotoxic effects to the vero cells and none of them inhibited cyclooxygenase-2 enzyme.
Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand.
Sunit
S
Suksamrarn
Kanjana
K
Wongkrajang
Kanyawim
K
Kirtikara
Apichart
A
Suksamrarn
D027901:Acanthaceae; D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D035264:Flowers; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D039823:Iridoids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000998:Antiviral Agents; D039823:Iridoids; D010936:Plant Extracts