A new model linking intrathymic acetylcholine receptor expression and the pathogenesis of myasthenia gravis.
The thymus is thought to play an important role in the pathogenesis of myasthenia gravis (MG), an autoimmune disease characterized by skeletal muscle weakness. However, its role remains a mystery. The studies described represent our efforts to determine how intrathymic expression of the neuromuscular type of acetylcholine receptors (nAChRs) is involved in the immunopathogenesis of MG. We review our work characterizing the expression of the alpha subunit of nAChR (nAChRalpha) in the thymus and advance a new hypothesis that examines the intrathymic expression of this autoantigen in disease pathogenesis.
Allergy and Immunology Section, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6160, USA. rog@mail.med.upenn.edu
Arnold I
AI
Levinson
Yi
Y
Zheng
Glen
G
Gaulton
Jonni
J
Moore
C Hank
CH
Pletcher
Decheng
D
Song
Lisa M
LM
Wheatley
D000818:Animals; D016207:Cytokines / Q000494:pharmacology; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007249:Inflammation / Q000821:virology; D009052:Leukemia Virus, Murine / Q000472:pathogenicity; D051379:Mice; D018482:Muscle, Skeletal / Q000378:metabolism; D009157:Myasthenia Gravis / Q000150:complications / Q000209:etiology* / Q000276:immunology; D020033:Protein Isoforms / Q000096:biosynthesis / Q000235:genetics; D011950:Receptors, Cholinergic / Q000096:biosynthesis* / Q000235:genetics; D013945:Thymoma / Q000150:complications / Q000276:immunology; D013950:Thymus Gland / Q000378:metabolism*
D016207:Cytokines; D020033:Protein Isoforms; D011950:Receptors, Cholinergic