Prevalence and clinical significance of incidental paraprosthetic valvar regurgitation: a prospective study using transoesophageal echocardiography.
OBJECTIVE
To assess the prevalence, mechanisms, and significance of paraprosthetic regurgitation detected incidentally by transoesophageal echocardiography (TOE) in patients after heart valve replacement.


METHODS
Prospective observational study.


METHODS
Tertiary referral centre.


METHODS
360 consecutive patients (mean (SD) age 65.8(9.5) years, 193 women) undergoing elective first ever valve replacement.


METHODS
Postoperative and follow up TOE, and tests for haemolysis and anaemia.


RESULTS
There were 243 aortic, 90 mitral, and 27 double valve replacements, using 316 mechanical and 44 tissue valves, giving 270 aortic and 117 mitral valves. One patient with severe paraprosthetic mitral regurgitation underwent immediate reoperation and was excluded from subsequent analyses. Paraprosthetic jets were detected around 16 (6%) of the aortic and 38 (32%) of the mitral valves (p < 0.05) at the postoperative study. Follow up TOE was available for 151 aortic and 67 mitral valves, 0.9 (0.5) years after operation. Paraprosthetic jets were present in 15 (10%) of the aortic and 10 (15%) of the mitral valves (NS). Two thirds of the aortic and a fifth of the mitral jets were new. Paraprosthetic jets were more common in aortic valves in a supra-annular (12 of 88, 14%) than in an intra-annular position (4 or 182, 2%; p < 0.005) and in mitral valves inserted with continuous (36 of 88, 41%) rather than interrupted sutures (2 of 28, 7%; p < 0.001). Lactate dehydrogenase concentration was higher in patients with paraprosthetic jets than in those without (752 (236) v 654 (208) IU/l, p < 0.001). Haemoglobin and haptoglobin concentrations were not different.


CONCLUSIONS
Small paraprosthetic leaks are common, are related to surgical factors, are not associated with increased subclinical haemolysis, and are benign during the first year after heart valve replacement.
Ionescu
A
A
University of Wales College of Medicine, Cardiff, UK. ionescu@cf.ac.uk
Fraser
A G
AG
Butchart
E G
EG
D000368:Aged; D000743:Anemia, Hemolytic / Q000209:etiology; D001022:Aortic Valve Insufficiency / Q000601:surgery*; D017548:Echocardiography, Transesophageal / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis / Q000592:standards*; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006461:Hemolysis; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008944:Mitral Valve Insufficiency / Q000601:surgery*; D011446:Prospective Studies; D011475:Prosthesis Failure; D012086:Reoperation; D013536:Suture Techniques