Survivin in apoptosis control and cell cycle regulation in cancer.
Evasion of apoptosis, and the ability to proliferate uncontrollably are two of the molecular traits found perhaps in all human cancers (1). Positioned at the interface between the regulation of apoptosis and the control of cell proliferation, survivin is a recently described molecule that is expressed in most human cancers but not in normal tissues. Encouraging new studies demonstrate that it may be possible to exploit the survivin pathway for cancer diagnosis and therapy.
Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.
Dario C
DC
Altieri
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics*; D014408:Biomarkers, Tumor; D002453:Cell Cycle / Q000187:drug effects / Q000235:genetics*; D018816:Genes, cdc / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins / Q000037:antagonists & inhibitors / Q000235:genetics*; D009363:Neoplasm Proteins; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D011237:Predictive Value of Tests; D000077022:Survivin
D000970:Antineoplastic Agents; C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin