Genes of aging.
According to developmental genetics theories, aging is a genetically programmed and controlled continuum of development and maturation. Being dynamic and malleable processes, development and aging are controlled not only by genes but also by environmental and epigenetic influences that predominate in the second half of life. Genetic mutations affect many phenotypes in flies, worms, rodents, and humans which share several diseases or their equivalents, including cancer, neurodegeneration, and infectious disorders as well as their susceptibility to them. Life span and stress resistance are closely linked. Oxidative stress actually constitutes a defined hypothesis of aging in that macromolecule oxidative damage accumulates with age and tends to be associated with life expectancy. DNA methylation, a force in the regulation of gene expression, is also one of the biomarkers of genetic damage. The mitotic clock of aging is marked, if not guided, by telomeres, essential genetic elements stabilizing natural chromosomic ends. The dream of humans to live longer, healthy lives is being tested by attempts to modify longevity in animal models, frequently by dietary manipulation. The quest continues to understand the mechanisms of healthy aging, one of the most compelling areas of research in the 21st century.
Centre de recherche, CHUM-Hôtel-Dieu, Université Montréal, Montréal, Québec, Canada.
Pavel
P
Hamet
Johanne
J
Tremblay
D000375:Aging / Q000235:genetics*; D000818:Animals; D019175:DNA Methylation; D006801:Humans; D008136:Longevity / Q000235:genetics; D009154:Mutation; D018384:Oxidative Stress; D016615:Telomere