[Aptameric DNA--a new type of thrombin inhibitor].
The formation of complexes between various thrombin preparations and a 30-mer aptamer DNA was comparatively studied, and a correlation between the complex formation and the fibrinogen-hydrolyzing activity of thrombin was found. The aptamer DNA was shown to inhibit the fibrin formation from fibrinogen.
Spiridonova
V A
VA
Belozersky Institute of Physicochemical Biology, Moscow State University, Vorob'evy gory, Moscow, 119992 Russia. spiridon@genebee.msu.su
Rog
E V
EV
Dugina
T N
TN
Strukova
S M
SM
Kopylov
A M
AM
D000991:Antithrombins / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry / Q000494:pharmacology*; D005340:Fibrinogen / Q000378:metabolism; D006868:Hydrolysis; D008958:Models, Molecular; D011487:Protein Conformation
D000991:Antithrombins; D005340:Fibrinogen; D004247:DNA