Stereoselective synthesis of tetrahydropyran-3-ones by rearrangement of oxonium ylides generated from metal carbenoids.
The synthesis of tetrahydropyran-3-ones by copper-catalysed reactions of diazo ketone tethered allylic ethers has been explored. Product distribution can be explained by the intermediacy of a free ylide or direct rearrangement of a metal-bound ylide equivalent.
Clark
J Stephen
JS
School of Chemistry, University of Nottingham, University Park, Nottingham, UK NG7 2RD. j.s.clark@nottingham.ac.uk
Whitlock
Gavin
G
Jiang
Shende
S
Onyia
Ngozi
N