Different susceptibility of facilitatory and inhibitory spinal pathways to ischemia in the cat.
The sensitivity of different excitatory and inhibitory segmental reflex pathways to ischemia was investigated by monosynaptic reflex testing in the spinal cat. Spinal cord ischemia was established by aortal snare occlusion of 1-10 min duration. Excitatory and inhibitory spinal pathways showed statistically significant different susceptibility to ischemic impact. In the period of decreasing responses after the onset of ischemia the transmission through oligo- or polysynaptic, facilitatory or inhibitory pathways was found to be depressed earlier than that of monosynaptic pathways. The period from the end of ischemia until the beginning of recovery of reflex effects was significantly longer for inhibitory effects, compared to the monosynaptic reflexes alone.The results indicated that interneurones of excitatory segmental pathways may be less sensitive to ischemia than motoneurones, and motoneurones seem to be less sensitive to ischemia than interneurones of inhibitory pathways. In high spinal animals, with a relatively high level of extensor inhibition, the enhanced excitability of inhibitory interneurones to GS motoneurones may be responsible for their sensitivity to ischemia, due to an increased rate of O(2) consumption and exhaustion of high-energy phosphate resources.
Kolenda
Herbert
H
Department of Neurosurgery, Diakoniekrankenhaus Rotenburg, Elise-Averdieck-Strasse 17, D-27356 (Wümme), Rotenburg, Germany.
Steffens
Heinz
H
Hagenah
Johann
J
Schomburg
Eike Dieter
ED
D000818:Animals; D002415:Cats; D007511:Ischemia / Q000503:physiopathology*; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012023:Reflex, Monosynaptic / Q000502:physiology; D013116:Spinal Cord / Q000098:blood supply* / Q000502:physiology*