Triethylene tetraamine: a novel telomerase inhibitor.
Telomerase inhibition can be achieved by stabilization of G-quadruplex structure. Triethylene tetraamine, a small linear molecule, has been identified as a potent telomerase inhibitor. It stabilizes both intra- and inter-molecular G-quadruplexes and shows a good differential between potent telomerase inhibition and acute cytotoxicity.
State Key Laboratory of Fine Chemicals, Dalian University of Technology, 158 Zhong-shan Road, 116012 Dalian, P.R. China.
Fei
F
Yin
Jianhui
J
Liu
Xiaojun
X
Peng
D000818:Animals; D001483:Base Sequence; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D008322:Mammals; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D019098:Telomerase / Q000037:antagonists & inhibitors*; D014266:Trientine / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D009838:Oligodeoxyribonucleotides; D004247:DNA; D019098:Telomerase; D014266:Trientine