A genome wide scan for association with multiple sclerosis in a N. Irish case control population.
In order to screen the genome for linkage disequilibrium (LD) in multiple sclerosis (MS), we typed 2537 microsatellite markers in separately pooled DNA from 200 cases and 200 controls from N. Ireland. Twenty two markers showing significant evidence of association were identified including three from the HLA region on chromosome 6p21. Putative candidate genes mapping close to the 19 novel markers include the IL10RA and CD3E genes on 11q23 (which both lie close to the marker D11S1998). Individual typing of the marker D11S1998 confirmed its association.
Regional Genetics Service, Belfast City Hospital, Belfast, UK.
Shirley
S
Heggarty
Stephen
S
Sawcer
Stanley
S
Hawkins
Gavin
G
McDonnell
Aidan
A
Droogan
Koen
K
Vandenbroeck
Michael
M
Hutchinson
Efrosini
E
Setakis
Alastair
A
Compston
Colin
C
Graham
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D019075:Electrophoresis, Capillary / Q000706:statistics & numerical data; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods* / Q000706:statistics & numerical data; D005828:Genetics, Population / Q000379:methods / Q000706:statistics & numerical data; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D007391:International Cooperation; D008297:Male; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D009660:Northern Ireland / Q000453:epidemiology; D016133:Polymerase Chain Reaction / Q000706:statistics & numerical data