A biochemical-based model for the dosimetry of dietary organically bound tritium--Part 2: Dosimetric evaluation.
In this paper the dosimetry for a novel form of physiological model, whose biokinetics are governed by the overall metabolic reactions of the principal nutrients carbohydrates, fats and proteins, is evaluated by compartmental analysis. Two models of differing complexity, called the HCNO-S and HCNO-C models, were developed from parameters evaluated in an accompanying paper. The simpler form has single compartments representing the principal nutrients. The more complex model includes compartments representing the longer-term retention of carbohydrates as glycogen, fats as adipose tissue, and proteins in bone and soft tissues. The effective doses for various tritiated intakes are the same, or similar, as calculated by the two HCNO models, except for tritiated protein. The dose coefficient for an intake of tritiated water is approximately 8% greater than that recommended by the ICRP when the tritium body burden is considered as a homogenous pool. However, when the composition of individual organs is taken into account, the dose coefficient for an HTO intake is approximately 22% greater than the ICRP value. The HCNO-C dose coefficient for OBT in a normal diet is 5.0 x 10(-11) Sv Bq(-1), which is 1.2-fold greater than the ICRP dose coefficient for an OBT intake. The HCNO-C composition model gave organ and tissue doses with the largest range for a tritiated Reference Man dietary intake, the highest dose (red marrow, then breast) being around three-fold the lowest. A property of the HCNO models, important for bioassay analyses, is that a major part (> 90%) of an OBT intake is oxidized and excreted as HTO, which is physiologically more accurate than the current ICRP OBT model. The effective dose of specific tritiated foods, e.g., rice and wheat, was evaluated on the basis of their constituents.
Radiation Biology and Health Physics Branch, Atomic Energy of Canada Limited, Chalk River Laboratories, Chalk River, Ontario, Canada K0J 1J0. richardr@aecl.ca
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Richardson
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Dunford
D000284:Administration, Oral; D001822:Body Burden; D003198:Computer Simulation; D004040:Dietary Carbohydrates / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism; D004044:Dietary Proteins / Q000378:metabolism; D004064:Digestive System / Q000378:metabolism*; D005507:Food Contamination, Radioactive / Q000032:analysis*; D006801:Humans; D008657:Metabolic Clearance Rate / Q000502:physiology; D008660:Metabolism / Q000502:physiology; D008954:Models, Biological; D009928:Organ Specificity; D011829:Radiation Dosage; D011835:Radiation Protection / Q000379:methods; D011874:Radiometry / Q000379:methods* / Q000592:standards; D014316:Tritium / Q000008:administration & dosage / Q000032:analysis* / Q000493:pharmacokinetics*; D014566:Urogenital System / Q000378:metabolism*
D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D014316:Tritium