title: [A case of multiple advanced esophageal carcinomas with abdominal LN metastases showing complete response after chemoradiotherapy with concurrent cisplatin, 5-FU and adriamycin chemotherapy].
abstract: We report the response of our new regimen of chemoradiotherapy for advanced esophageal carcinoma. The patient was a 66-year-old man who had double primary esophageal carcinomas: type o-IIc tumor of the cervical esophagus from the esophageal inlet to 23 cm from incisors and a 9 cm length type 3 tumor of the middle to lower thoracic esophagus with a 2 cm diameter cardiac lymph node metastasis. Since he completely rejected surgical treatment, new definitive chemoradiotherapy with 2 courses of FAP chemotherapy (cisplatin 50 mg/m2 and adriamycin 20 mg/m2 on day 1 and 5-FU 700 mg/day from day 1 to 5 continuously) concurrent with a split course of radiotherapy to a total dose of 60 Gy in 30 fractions was devised and administered. The treatment was completed and there was no severe toxicity except grade 3 leukocytopenia. Just after treatment, cervical tumor and cardiac lymph node reached complete response but stenosis and wall thickness remained in the thoracic tumor. Soon after, however, these findings improved and, at present 1 year later, complete response has continued. Our new regimen of chemoradiotherapy concurrent with FAP chemotherapy seems to be effective and promising for advanced esophageal carcinoma.
authors: Dept. of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University.
authors: Takushi
authors: T
authors: Yasuda
authors: Masahiko
authors: M
authors: Yano
authors: Shuji
authors: S
authors: Takiguchi
authors: Yutaka
authors: Y
authors: Kimura
authors: Yoshiyuki
authors: Y
authors: Fujiwara
authors: Morito
authors: M
authors: Monden
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D012074:Remission Induction
chemical_list: D004317:Doxorubicin; D002945:Cisplatin; D005472:Fluorouracil