Expression of nm23-H1 is associated with poor prognosis in peripheral T-cell lymphoma.
We have reported previously that the serum nm23-H1 level is a prognostic factor for non-Hodgkin's lymphoma. In this study, we examined nm23-H1 expression in T- and natural killer (NK)-cell lymphoma in order to evaluate whether lymphoma cells produce the protein. The clinical significance of the cytotoxic molecules, T-cell intracellular antigen-1 (TIA-1) and granzyme B and nm23-H1 expression were also examined. Expression of nm23-H1, TIA-1, or granzyme B was examined by immunohistochemistry in 137 previously untreated lymphoma patients. The relationship between the results and clinical outcome was examined in 81 patients with angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma, or peripheral T-cell lymphoma, unspecified. The neoplastic cells of some lymphomas produced nm23-H1 and the expression rates of nm-23-H1, TIA-1 and granzyme B were 36.5%, 78.8% and 32.8% respectively. The nm23-H1-positive or TIA-1-positive groups had significantly shorter overall and disease-free survivals. Multivariate analysis confirmed nm23-H1 expression to be an independent prognostic factor. The nm23-H1 protein can be an important prognostic factor in the lymphomas studied here. New treatments that target nm23 overexpression could be developed as a result of nm23-HI production by lymphoma cells.
Niitsu
Nozomi
N
Department of Hematology and Internal Medicine IV, Kitasato University School of Medicine, Kanagawa, Japan. nniitsu@med.kitasato-u.ac.jp
Nakamine
Hirokazu
H
Okamoto
Masataka
M
Akamatsu
Hiroko
H
Honma
Yoshio
Y
Higashihara
Masaaki
M
Okabe-Kado
Junko
J
Hirano
Masami
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D018572:Disease-Free Survival; D005260:Female; D053804:Granzymes; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008207:Lymphatic Metastasis; D016399:Lymphoma, T-Cell / Q000737:chemistry* / Q000401:mortality; D008297:Male; D008565:Membrane Proteins / Q000032:analysis; D008875:Middle Aged; D020559:Monomeric GTP-Binding Proteins / Q000032:analysis*; D015999:Multivariate Analysis; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase; D039102:Poly(A)-Binding Proteins; D011379:Prognosis; D011506:Proteins; D016601:RNA-Binding Proteins / Q000032:analysis; D012697:Serine Endopeptidases / Q000032:analysis; D015996:Survival Rate; D000074019:T-Cell Intracellular Antigen-1; D014157:Transcription Factors / Q000032:analysis*
D014408:Biomarkers, Tumor; D008565:Membrane Proteins; D054778:NM23 Nucleoside Diphosphate Kinases; D039102:Poly(A)-Binding Proteins; D011506:Proteins; D016601:RNA-Binding Proteins; D000074019:T-Cell Intracellular Antigen-1; C071558:TIA1 protein, human; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; C509213:GZMB protein, human; D053804:Granzymes; D012697:Serine Endopeptidases; D020559:Monomeric GTP-Binding Proteins