[Successful treatment of postoperative multiple hepatic recurrence with hepatic arterial infusion of cisplatin and degrable starch microspheres].
A 38-year-old man had multiple recurrence of hepatocellular carcinoma (HCC) with portal vein thrombosis after hepatectomy and postoperative transcatheter arterial chemotherapy with 5-fluorouracil (5-FU). He was treated by trans hepatic arterial embolization (TAE) with 100 mg of cisplatin (CDDP) and degrable starch microspheres (DSM). After 3 courses were administered, the recurrent lesions almost disappeared on CT, and the postoperative rise in PIVKA-II level and AFP level normalized. There were no side effects except slight fever and general fatigue. We recognized a partial response, and the patient is still alive 14 months after hepatectomy. This case suggests that TAE with CDDP and DSM might be useful for prolonging the survival of advanced HCC patients.
Murakami
Masahiro
M
Dept. of Surgery, NTT West Osaka Hospital.
Tono
Takeshi
T
Imazato
Mitsunobu
M
Takemoto
Hirotoshi
H
Asaoka
Tadashi
T
Okada
Kazuyuki
K
Kanoh
Toshiyuki
T
Iwazawa
Takashi
T
Ohnishi
Tadashi
T
Nakano
Yoshiaki
Y
Yano
Hiroshi
H
Kinuta
Masakatsu
M
Okamura
Jyun
J
Monden
Takushi
T
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D015415:Biomarkers; D014408:Biomarkers, Tumor / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D002945:Cisplatin / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D006498:Hepatectomy; D006499:Hepatic Artery; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000097:blood / Q000628:therapy*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D011169:Portal Vein; D011498:Protein Precursors / Q000097:blood; D011516:Prothrombin; D013213:Starch / Q000008:administration & dosage*; D013927:Thrombosis / Q000209:etiology
D000970:Antineoplastic Agents; D015415:Biomarkers; D014408:Biomarkers, Tumor; D011498:Protein Precursors; C083286:degradable starch microspheres; C008208:acarboxyprothrombin; D011516:Prothrombin; D013213:Starch; D002945:Cisplatin