Correlation of GDF5 and connexin 43 mRNA expression during embryonic development.
Growth/differentiation factor 5 (GDF5) regulates connexin expression and enhances embryonic chondrogenesis in a gap junction-dependent manner, suggesting that GDF5 action on developmental skeletogenesis is coordinated with gap junction activities. The results shown here demonstrate concordance between the mRNA expression profiles of GDF5 and the gap junction gene, Cx43, in the mouse embryonic limb, spine, and heart, consistent with coordinated functions for these gene products during developmental organogenesis.
Coleman
Cynthia M
CM
National Institute of Arthritis, and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Loredo
Grace A
GA
Lo
Cecilia W
CW
Tuan
Rocky S
RS
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000235:genetics / Q000378:metabolism*; D020219:Chondrogenesis / Q000235:genetics; D018031:Connexin 43 / Q000235:genetics / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D005318:Fetal Heart / Q000254:growth & development; D017629:Gap Junctions / Q000235:genetics / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D055428:Growth Differentiation Factor 5; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism*; D013131:Spine / Q000254:growth & development; D013710:Tendons / Q000254:growth & development
D019485:Bone Morphogenetic Proteins; D018031:Connexin 43; C525894:Gdf5 protein, mouse; D055428:Growth Differentiation Factor 5; D012333:RNA, Messenger