title: Psycho-endocrine-immune response to mindfulness-based stress reduction in individuals infected with the human immunodeficiency virus: a quasiexperimental study.
abstract: OBJECTIVE
  The purpose of this study was to examine the effects of a structured, 8-week, Mindfulness-Based Stress Reduction (MBSR) program on perceived stress, mood, endocrine function, immunity, and functional health outcomes in individuals infected with the human immunodeficiency virus (HIV).
  
  
  METHODS
  This study used a quasiexperimental, nonrandomized design.
  
  
  METHODS
  Subjects were specifically recruited (nonrandom) for intervention (MBSR) or comparison group. Data were collected at pretest and post-test in the MBSR group and at matched times in the comparison group. t Tests where performed to determine within-group changes and between-group differences.
  
  
  RESULTS
  Natural killer cell activity and number increased significantly in the MBSR group compared to the comparison group. No significant changes or differences were found for psychological, endocrine, or functional health variables.
  
  
  CONCLUSIONS
  These results provide tentative evidence that MBSR may assist in improving immunity in individuals infected with HIV.
authors: College of Nursing, University of Illinois at Chicago, Chicago, IL 60612-7350, USA. prphd@uic.edu
authors: F Patrick
authors: FP
authors: Robinson
authors: Herbert L
authors: HL
authors: Mathews
authors: Linda
authors: L
authors: Witek-Janusek
mesh_terms: D000328:Adult; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000523:psychology / Q000628:therapy*; D015438:Health Behavior; D006293:Health Promotion / Q000379:methods; D006801:Humans; D008297:Male; D019122:Meditation / Q000379:methods / Q000523:psychology; D008875:Middle Aged; D011603:Psychophysiology; D013315:Stress, Psychological / Q000276:immunology* / Q000517:prevention & control*; D013997:Time Factors; D016896:Treatment Outcome