title: Steroids and the reversal of age-associated changes in myelination and remyelination.
abstract: The myelin sheaths that surround all but the smallest diameter axons within the mammalian central nervous system (CNS) must maintain their structural integrity for many years. Like many tissues, however, this function is prone to the effects of ageing, and various structural anomalies become apparent in the aged CNS. Similarly, the regenerative process by which myelin sheaths, lost as a consequence of exposure to a demyelinating insult, are restored (remyelination) is also affected by age. As animals grow older, the efficiency of remyelination progressively declines. In this article, we review both phenomena and describe how both can be partially reversed by steroid hormones and their derivatives.
authors: INSERM U488, 80 rue du Général Leclerc, 94276 Le Kremlin Bicêtre-Cedex, France.
authors: C
authors: C
authors: Ibanez
authors: S A
authors: SA
authors: Shields
authors: M
authors: M
authors: El-Etr
authors: E
authors: E
authors: Leonelli
authors: V
authors: V
authors: Magnaghi
authors: W-W
authors: WW
authors: Li
authors: F J
authors: FJ
authors: Sim
authors: E-E
authors: EE
authors: Baulieu
authors: R C
authors: RC
authors: Melcangi
authors: M
authors: M
authors: Schumacher
authors: R J M
authors: RJ
authors: Franklin
mesh_terms: D000375:Aging; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D006801:Humans; D009186:Myelin Sheath / Q000187:drug effects*; D009416:Nerve Regeneration / Q000187:drug effects*; D011374:Progesterone / Q000494:pharmacology; D013256:Steroids / Q000494:pharmacology*
chemical_list: D013256:Steroids; D011374:Progesterone