title: Skeletal disproportion in children with chronic renal disease.
abstract: OBJECTIVE
  To assess stature and skeletal disproportion in children with chronic renal disease.
  
  
  METHODS
  Cross-sectional study of height (HT), sitting height (SH), subischial leg length (SILL), sitting height/height ratio (SH:HT) and disproportion score (SH SDS minus SILL SDS) in 56 children (M:35) with median age 11.4 years (range 4.5,18.7) with chronic renal disease.
  
  
  RESULTS
  There were 19 children with chronic renal insufficiency, 6 receiving peritoneal dialysis and 31 after renal transplant. The median HTSDS for the whole group was -1.21 (-2.8, 0.35). The median SH:HT ratio in non-transplanted children and renal transplant were 0.51 (0.49, 0.53) and 0.50 (0.48, 0.53), respectively (p = 0.02). The median disproportion score of the whole group was -3.2 (-4.8, -1.8). There was a significant correlation between disproportion score and SH:HT (r = 0.5, p = 0.005). SH:HT ratio was negatively related to duration of illness (r = 0.4, p = 0.005).
  
  
  CONCLUSIONS
  Children with chronic renal disease have significant body disproportion and this may be due to a disproportionately greater effect of disease and treatment on spinal growth.
authors: Bone and Endocrine Research Group, Royal Hospital for Sick Children, Yorkhill, Glasgow, UK.
authors: Nadia
authors: N
authors: Qayyum
authors: Lolita
authors: L
authors: Alcocer
authors: Heather
authors: H
authors: Maxwell
authors: T James
authors: TJ
authors: Beattie
authors: Anna V
authors: AV
authors: Murphy
authors: Ian J
authors: IJ
authors: Ramage
authors: S Faisal
authors: SF
authors: Ahmed
mesh_terms: D000293:Adolescent; D000886:Anthropometry / Q000379:methods; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D005260:Female; D006130:Growth Disorders / Q000453:epidemiology / Q000209:etiology*; D019382:Human Growth Hormone / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000473:pathology* / Q000628:therapy; D016030:Kidney Transplantation; D008137:Longitudinal Studies; D008297:Male; D015995:Prevalence; D012044:Regression Analysis
chemical_list: D019382:Human Growth Hormone