title: [Combined use of anaprilin and thiamine in the treatment of ischemic heart disease].
abstract: In 60 patients with stable functional class II exertional angina with hyperkinetic type of circulation, baseline hemodynamics was studied following a 2-week treatment. A negatively chrono- and inotrophic effect was observed with taking anaprilin in a dose of 160 mg per day and a dose of 80 mg per day combined with 2 ml of 5 per cent solution of thiamine-chloride in injections. No effect was elicited with an 80 mg/d anaprilin without thiamine. The use of anaprilin and thiamine combined in treatment of IHD patients permits to reduce doses of beta-adrenoblockers as large doses of it may result in heart failure.
authors: V N
authors: VN
authors: Vodoevich
authors: T A
authors: TA
authors: Vinogradova
authors: L D
authors: LD
authors: Kulesh
authors: V V
authors: VV
authors: Vinogradov
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy*; D011433:Propranolol / Q000008:administration & dosage / Q000627:therapeutic use*; D013831:Thiamine / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000319:Adrenergic beta-Antagonists; D011433:Propranolol; D013831:Thiamine