A case of familial psoriasis with predominant hand involvement.
Psoriasis has been recognized as a familial disease with a polygenic inheritance. A case is reported of a father and four of his seven children with plaque psoriasis localized to the hands. The other three children are not afflicted by psoriasis. All patients developed psoriasis at 5 years of age. Only one member of this family has involvement in an area other than the hands. This case illustrates some of the complexities of the genetics of psoriasis.
Gottlieb
Alice B
AB
UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA. gottliab@umdnj.edu
Weisfelner
Michelle E
ME
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006229:Hand Dermatoses / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree; D011565:Psoriasis / Q000235:genetics*