[Expression of HSD17beta2 gene in the fetal lung and placenta: control of sex steroid action].
During gestation, sex steroids could potentially have detrimental effects on fetal development. At least two distinct mechanisms should prevent such effects. The 17beta-hydroxysteroid dehydrogenase-2 (HSD17beta2) plays a key role in each mechanism. Being expressed both in lung fibroblasts and placental endothelial cells, the HSD17beta2 should restrict testosterone and estradiol actions, thus enabling normal development.
Tremblay
Yves
Y
Unité d'Ontogénie et Reproduction, Centre hospitalier universitaire Laval (CHUL), Département d'Obstétrique et Gynécologie, Faculté de Médecine, Université Laval, 2705, boulevard Laurier, Sainte-Foy, Québec, G1V 4G2, Canada. yves.tremblay@crcuhl.ulaval.ca
Provost
Pierre R
PR
D005314:Embryonic and Fetal Development; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005347:Fibroblasts / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D006913:Hydroxysteroid Dehydrogenases / Q000096:biosynthesis* / Q000235:genetics*; D008168:Lung / Q000196:embryology / Q000502:physiology; D008297:Male; D010920:Placenta / Q000502:physiology; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D004958:Estradiol; D006913:Hydroxysteroid Dehydrogenases; C035507:3(17)-hydroxysteroid dehydrogenase