[Surgical stress and biochemical indicators].
OBJECTIVE
An investigation of some relationships of routinely and rarely used biochemical markers to surgical (operating) trauma.


METHODS
A group of 37 patients was divided to two subgroups according type of disease with need a resection of large bowel for malignant or benign malady. Large bowel adenocarcinoma was dominated in a subgroup of malignancies (23 patients, mean BMI 25.59, mean age 63.65 years) and Crohn's disease and complicated diverticullary disease were the reasons to operate in the second subgroup of benignities (14 patients, mean BMI 21.21, mean age 39.5 year). Blood samples were taken before an operation, postoperatively (immediately) and at 6:00 a.m. the 1st, 3rd and 5th postoperative day. The routine methods (albumin, CRP, cholinesterase, haptoglobin, cholesterol), special methods (SOD, glutathion) and ELISA methods (leptin, IL-2r, IL-8, TNF)were used for evaluation markers. The results were estimated by statistic methods Sigma-Stat, One Way ANOVA and linear regression test.


RESULTS
The mean serum concentrations of albumin, leptin, cholesterol shifted down very clearly compared to preoperative values. The mean serum concentrations shifted up the 3rd day postoperatively to 722% in benignities and to 1814% in malignancies respectively. The values of cholinesterase, glutation, SOD, and haptoglobin didn't show any more serious dynamics perioperatively. The serum leptin concentrations correlated with BMI but other markers serum concentrations didn't correlate with BMI or with age.


CONCLUSIONS
The serum leptin, albumin, haptoglobin, CRP concentrations demonstrated serious dynamics perioperatively. These concentrations are stabilized and they reach preoperative levels the 5th postoperative day. Each-other markers correlation is minimal.
Kaska
M
M
Chirurgická klinika, LF a FN v Hradci Králové.
Zivný
P
P
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D007420:Intestine, Large / Q000601:surgery*; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000032:analysis; D013312:Stress, Physiological / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*
D015415:Biomarkers; D006242:Haptoglobins; D020738:Leptin; D012709:Serum Albumin; D002097:C-Reactive Protein; D002784:Cholesterol