title: Mitochondrial bioenergetics, aging, and aging-related disease.
abstract: In this Perspective, the author discusses some of the bioenergetic consequences of the various alterations in mitochondrial function that have been hypothesized to be associated with human aging and aging-related disease. Special focus is afforded to neurodegenerative disease.
authors: Buck Institute for Age Research, Novato, CA 94945, USA. dnicholls@buckinstitute.org
authors: David
authors: D
authors: Nicholls
mesh_terms: D000375:Aging / Q000473:pathology / Q000502:physiology*; D000818:Animals; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D007425:Intracellular Membranes / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology