Calcitonin administration in a rabbit distraction osteogenesis model.
The effect of salmon calcitonin on the maturation of the regenerate bone was assessed in an experimental model in rabbits. Twenty-six New Zealand White male rabbits, approximately 5 months old and weighing 3 to 3.5 kg, were subjected to a mid-diaphyseal tibial osteotomy. After 5 days, the right tibia was lengthened gradually at a rate of 0.375 mm every 12 hours, for 10 days. Ten international units of salmon calcitonin were administered daily subcutaneously to the study group (14 animals), whereas the animals of the control group (12 animals) were injected with a placebo, for the duration of the experiment. The bone mineral density of the regenerate bone was assessed on Days 20, 35, 45, and 55 of the experiment, in both groups, using dual energy xray absorptiometry. No statistical significant difference was found in the dual energy xray absorptiometry measurements between the study and control groups regarding the change of the bone mineral density of the new bone relative to a preoperative baseline measurement. Characteristic time-related changes were observed in the bone mineral density of the regenerate bone during its maturation, which proved to be identical in both groups. It seems that the administration of calcitonin does not enhance regenerate bone mineralization rate and tendency during bone lengthening.
Kokoroghiannis
Constantine
C
Th Garofallides Laboratory for the Research of the Musculoskeletal System. katago@delta.gr
Papaïoannou
Nicolaos
N
Lyritis
Georgios
G
Katsiri
Maria
M
Kalogera
Popi
P
D015502:Absorptiometry, Photon; D000704:Analysis of Variance; D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D001861:Bone Regeneration / Q000187:drug effects; D002116:Calcitonin / Q000008:administration & dosage* / Q000494:pharmacology; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical; D007279:Injections, Subcutaneous; D007870:Leg Length Inequality / Q000175:diagnosis / Q000628:therapy; D008297:Male; D019857:Osteogenesis, Distraction / Q000379:methods; D011817:Rabbits; D013977:Tibia / Q000187:drug effects*; D013997:Time Factors
C028815:salmon calcitonin; D002116:Calcitonin