title: Thiourea inhibitors of herpes viruses. Part 1: bis-(aryl)thiourea inhibitors of CMV.
abstract: Bis-(aryl)thioureas were found to be potent and selective inhibitors of cytomegalovirus (CMV) in cultured HFF cells. Of these, the thiazole analogue 38 was investigated as a potential development candidate.
authors: Wyeth Research, Pearl River, NY 10965, USA. bloomj@wyeth.com
authors: Jonathan D
authors: JD
authors: Bloom
authors: Martin J
authors: MJ
authors: DiGrandi
authors: Russell G
authors: RG
authors: Dushin
authors: Kevin J
authors: KJ
authors: Curran
authors: Adma A
authors: AA
authors: Ross
authors: Emily B
authors: EB
authors: Norton
authors: Eugene
authors: E
authors: Terefenko
authors: Thomas R
authors: TR
authors: Jones
authors: Boris
authors: B
authors: Feld
authors: Stanley A
authors: SA
authors: Lang
mesh_terms: D000215:Acylation; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects*; D006564:Herpesviridae / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D001555:Benzene Derivatives; D013890:Thiourea