Grading of chemotherapy-induced peripheral neurotoxicity using the Total Neuropathy Scale.
The authors compared clinically based neurotoxicity scales with the Total Neuropathy Scale, with the aim of improving the grading of the severity of chemotherapy-induced peripheral neuropathy (CIPN). The severity of CIPN was evaluated in a series of 60 women treated with cisplatin- and paclitaxel-based chemotherapy. A reduced version of TNS (TNSr) was also compared. The authors concluded that the TNS and TNSr can be used to assess the severity of CIPN effectively, and the results of this evaluation can be reliably correlated with the oncologic grading of sensory peripheral neurotoxicity.
Cavaletti
G
G
Dipartimento di Neuroscienze e Tecnologie Biomediche, Università di Milano Bicocca, Monza, Italy. guido.cavaletti@unimib.it
Bogliun
G
G
Marzorati
L
L
Zincone
A
A
Piatti
M
M
Colombo
N
N
Parma
G
G
Lissoni
A
A
Fei
F
F
Cundari
S
S
Zanna
C
C
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D002945:Cisplatin / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions / Q000139:chemically induced / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects; D009460:Neurologic Examination; D017239:Paclitaxel / Q000009:adverse effects; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000175:diagnosis*; D012720:Severity of Illness Index; D043823:Taxoids / Q000009:adverse effects; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
D043823:Taxoids; D017239:Paclitaxel; D002945:Cisplatin; D007069:Ifosfamide