Estrano[17,16-e]pyrimidine-peptide conjugates.
The preparation of a steroidal heterocycle linked to the tripeptide Cys-Gly-Cys is described. Initially, an estrane-derived steroidal heterocycle containing an aminopyrimidine ring fused to the 16,17-position of the steroidal nucleus was synthesized. Thereafter, protected amino acids were coupled iteratively by the DCC method, commencing at the amino group of the aminopyrimidine unit.
Matsumoto
Tomohiro
T
Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, Kyushu, Japan.
Watanabe
Masataka
M
Mataka
Shuntaro
S
Thiemann
Thies
T
D003545:Cysteine / Q000737:chemistry; D004962:Estranes / Q000737:chemistry*; D005998:Glycine / Q000737:chemistry; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry*; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry
D004962:Estranes; D009842:Oligopeptides; D011743:Pyrimidines; D013256:Steroids; D003545:Cysteine; C030986:pyrimidine; D005998:Glycine