Priming the hematopoietic pump.
Markers of multiple hematopoietic lineages are expressed in multipotent progenitors, a phenomenon referred to as "lineage priming." A new study in this issue of Immunity provides compelling evidence that such "promiscuous" gene expression occurs in hematopoietic stem cells and does not interfere with their long-term repopulation potential.
Orkin
Stuart H
SH
Dana Farber Cancer Institute and Children's Hospital, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115, USA.
D002454:Cell Differentiation / Q000276:immunology / Q000502:physiology*; D005786:Gene Expression Regulation; D006412:Hematopoietic Stem Cells / Q000276:immunology / Q000502:physiology*; D006801:Humans; D009113:Muramidase / Q000378:metabolism
D009113:Muramidase