[Human molecular genetics: from monogenic to polygenic or complex disorders].
Human molecular genetics has successfully identified the genes involved in several monogenic disorders. It now aims at pinpointing the genetic determinants of polygenic or complex traits with a strong genetic component. This constitutes a new challenge. We discuss the methodological and practical aspects of identifying such genes as well as the challenges facing physicians that will have to use efficiently these new diagnostic tools.
Rousseau
François
F
Unité de recherche en génétique humaine et moléculaire, Centre de recherche de l'hôpital St-François-d'Assise du CHUQ, Université Laval, 10, rue de l'Espinay, Québec G1L 3L5, Canada.
Laflamme
Nathalie
N
D020022:Genetic Predisposition to Disease; D006801:Humans; D008967:Molecular Biology / Q000639:trends*; D020412:Multifactorial Inheritance