Expression of gec1/GABARAPL1 versus GABARAP mRNAs in human: predominance of gec1/GABARAPL1 in the central nervous system.
GABARAP and gec1/GABARAPL1 genes encode very similar proteins belonging to a new microtubule-associated protein (MAP) family. These proteins could participate in a complex clustering, targeting and/or degrading the GABA(A) receptors on post-synaptic membrane of neurons. Using specific cDNA probes, we investigated the differential expression of both genes in 76 human tissues. Against all odds, gec1/GABARAPL1 was more expressed than GABARAP in the central nervous system (CNS), while GABARAP was more expressed in endocrine glands.
Nemos
Christophe
C
Laboratoire de Biochimie-Biologie Moléculaire, Université de Franche-Comté, U.F.R. Sciences et Techniques, 16 route de Gray, 25030 Besançon cedex, France.
Mansuy
Virginie
V
Vernier-Magnin
Sandrine
S
Fraichard
Annick
A
Jouvenot
Michèle
M
Delage-Mourroux
Régis
R
D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; D002462:Cell Membrane / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism*; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D004702:Endocrine Glands / Q000378:metabolism*; D005333:Fetus; D015870:Gene Expression / Q000235:genetics*; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D011940:Receptor Aggregation / Q000235:genetics; D011963:Receptors, GABA-A / Q000378:metabolism; D009435:Synaptic Transmission / Q000235:genetics
D048868:Adaptor Proteins, Signal Transducing; D051017:Apoptosis Regulatory Proteins; C116741:GABARAP protein, human; C430503:GABARAPL1 protein, human; D008869:Microtubule-Associated Proteins; D012333:RNA, Messenger; D011963:Receptors, GABA-A