title: New furostanol glycosides from the rhizomes of Dioscorea futschauensis R. Kunth.
abstract: Two new furostanol glycosides, 26-O-beta-D-glucopyranosyl-3beta,26-dihydroxy-23(S)-methoxyl-25(R)-furosta-5,20(22)-dien-3-O-alpha-L-rhamnopyranosyl(1 --> 2)-[beta-D-glucopyranosyl(1 --> 3)]-beta-D-glucopyranoside (dioscoreside E, 1) and 26-O-beta-D-glucopyranosyl-3beta,26-dihydroxy-25(R)-furosta-5,20(22)-dien-3-O-alpha-Lrhamnopyranosyl(1 --> 2)-[beta-D-glucopyranosyl (1 --> 3)]-beta-D-glucopyranoside (prtotogracillin, 2), together with 11 known furostanol glycosides were isolated from the rhizomes of Dioscorea futshauensis R. Kunth. Their structures were elucidated on the basis of spectroscopic analysis (NMR and FABMS). Their anti-fungal activity against the plant pathogenic fungus Pyricularia oryzae and cytotoxic activity on K562 cancer cell line were evaluated in vitro.
authors: Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Wenhua-Road 103, Shenyang 110016, China.
authors: Hong-Wei
authors: HW
authors: Liu
authors: San-Long
authors: SL
authors: Wang
authors: Bin
authors: B
authors: Cai
authors: Ge-Xia
authors: GX
authors: Qu
authors: Xu-Juan
authors: XJ
authors: Yang
authors: Hisayoshi
authors: H
authors: Kobayashi
authors: Xin-Sheng
authors: XS
authors: Yao
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D027742:Dioscorea; D006027:Glycosides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D020014:K562 Cells / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D027343:Rhizome
chemical_list: D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D010936:Plant Extracts