title: Advantages of the intrabreath technique as a measure of lung function before and after heart transplantation.
abstract: BACKGROUND
  Pulmonary function testing is an integral part of evaluating patients who are being considered for cardiac transplantation. The accurate measurement of diffusing capacity (DLCO) and alveolar volume (VA) is dependent on a 10-s breath-holding maneuver that may be difficult for patients with congestive heart failure to perform. The intrabreath (IB) technique is not dependent on a breath-holding maneuver and may provide more accurate pulmonary function testing results in chronically debilitated patients.
  
  
  METHODS
  Seventy-five patients performed maneuvers with IB and single-breath (SB) techniques during evaluation for heart transplantation and at 3 and 12 months following transplantation. The DLCO, VA, and total lung capacity (TLC) were compared using Pearson correlation coefficients, a Student t test, and intercorrelation coefficients.
  
  
  RESULTS
  The DLCO and VA, when determined with the IB technique, had excellent correlations to the SB technique over all ranges of DLCO values. VA values that were determined by the IB technique were greater than those determined by the SB technique and more closely approximated the TLC values. The satisfactory correlation between the two techniques was maintained when DLCO was corrected for VA. However, due to the lower values for VA as determined by the SB method, the corrected measurements were consistently higher for the SB technique.
  
  
  CONCLUSIONS
  Pulmonary function can be measured accurately in a population of patients with long-standing congestive heart failure, both before and after cardiac transplantation, using the IB technique. Furthermore, the IB technique may provide a more accurate measurement of VA.
authors: Division of Cardiac Surgery, London Health Sciences Center, London, ON, Canada. maquants@uwo.ca
authors: Mackenzie
authors: M
authors: Quantz
authors: Steven
authors: S
authors: Wilson
authors: Charles
authors: C
authors: Smith
authors: Larry
authors: L
authors: Stitt
authors: Richard
authors: R
authors: Novick
authors: Dildar
authors: D
authors: Ahmad
mesh_terms: D005260:Female; D006333:Heart Failure / Q000503:physiopathology / Q000601:surgery; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011650:Pulmonary Alveoli / Q000503:physiopathology; D011653:Pulmonary Diffusing Capacity; D012129:Respiratory Function Tests / Q000379:methods*; D014109:Total Lung Capacity