title: [Adverse reactions to immunotherapy in pediatric patients].
abstract: BACKGROUND
  Specific immunotherapy involves administration of allergenic extract in order to reach clinical tolerance of the causal allergens in patients with allergic conditions. When administered, it can provoke side effects.
  
  
  OBJECTIVE
  To identify systemic reactions after specific immunotherapy administration.
  
  
  METHODS
  A retrospective trial from January 1996 to December 2000. We reviewed patients' files with an allergic disease diagnosis that received immunotherapy. We looked for adverse reactions at 20 minutes and immunotherapy sheets report. The results were analyzed by central and dispersion trends.
  
  
  RESULTS
  Annual average was of 1,168 applications, 51 (23%) had an adverse reaction. Average age was of 9.5 +/- 2.2 years. 76.5% were male. 125 (5.7%) patients abandoned the treatment and 2,025 (94.3%) continued it. The frequency of intermittent mild asthma/allergic rhinitis was of 51%, persistent moderate asthma/allergic rhinitis, 9.8, and allergic rhinitis, 9.8%. The most common allergen was Dermatophagoides (80.4%). The most frequent reactions were a wheal (64.7%) and exacerbation of clinic baseline (25.5%).
  
  
  CONCLUSIONS
  Percentage of patients with an immunotherapy immediate reaction was of 2.3% according to literature reports (2.1%).
authors: Departmento de Alergia e Inmunologia Clinica, Hospital Infantil de México Federico Gómez, Dr Márquez 162, Col, Doctores, Mexico, DF, 06729
authors: Lourdes
authors: L
authors: Avila Castañón
authors: Lourdes
authors: L
authors: Lerma-Ortiz
authors: Yadira
authors: Y
authors: Velázquez Armenta
authors: Blanca Estela
authors: BE
authors: del Rio Navarro
authors: Juan José
authors: JJ
authors: Sienra Monge
mesh_terms: D000485:Allergens / Q000009:adverse effects* / Q000627:therapeutic use; D000818:Animals; D002648:Child; D003876:Dermatitis, Atopic / Q000628:therapy; D003888:Desensitization, Immunologic / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology*; D006969:Hypersensitivity, Immediate / Q000209:etiology*; D008297:Male; D008925:Mites; D006109:Poaceae; D011058:Pollen; D012130:Respiratory Hypersensitivity / Q000628:therapy; D012189:Retrospective Studies; D012882:Skin Tests
chemical_list: D000485:Allergens