Orthotopic liver transplantation in treatment of 77 patients with end-stage hepatic disease.
OBJECTIVE
To summarize the experience of human orthotopic liver transplantation (OLTx) in treatment of patients with end-stage hepatic disease and their perioperative management.


METHODS
A retrospective analysis was made on OLTx performed in 77 patients from April 1993 to September 2001 in our department included combined liver-kidney transplantation (6 patients) and living related liver transplantation (2). Among them, 76 were adults and 1 was infant (67 males and 10 females). The donors included 75 non-heart beating donors and 2 living related donors. Veno-venous bypass was used only in 45 cases during the operation. immunosuppressive agents consisted of cyclosporine, cellcept, ALG corticosteroids and FK506.


RESULTS
The one-year survival rates of grafts and recipients with benign hepatic disease were 75%. The recipients this year are surviving with good function of grafts.


CONCLUSIONS
Liver transplantation is the best therapeutic method for a large number of patients with end-stage hepatic disease in China.
Zheng
Shu-Shen
SS
Department of Hepatobiliary Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. linzhou8@mail.hz.zj.cn
Huang
Dong-Sheng
DS
Wang
Wei-Lin
WL
Liang
Ting-Bo
TB
Zhang
Min
M
Shen
Yan
Y
Xu
Xiao
X
Wu
Jian
J
Yan
Sheng
S
Guo
Hua
H
Lu
An-Wei
AW
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018281:Cholangiocarcinoma / Q000401:mortality / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D017093:Liver Failure / Q000401:mortality* / Q000601:surgery*; D008113:Liver Neoplasms / Q000401:mortality / Q000601:surgery; D016031:Liver Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies