title: Impact of donor age on living related donor kidney transplantation.
abstract: Two comparable groups of kidney transplant recipients were identified according to the age of their kidney donors. The first group (A) comprised 42 recipients of donors aged < 40 years, and the second group (B) comprised 48 recipients of donors aged > 50 years. The patients were followed for a mean period of 26 months (range 13-50 months). Post-transplant renal function and graft survival were assessed together with the frequency of post-transplant proteinuria and hypertension. Moreover, the functional reserve of the grafts was determined by comparing the clearance values, obtained by both isotope and chemical means, before and after a combined infusion of dopamine and an amino acids preparation. The graft function was significantly better in group A according to the serum creatinine levels (micromol/l) at 1 month (107+/-4.5 vs. 134+/-10.7, P < 0.01), 12 months (119+/-5.3 vs. 181+/-88, P < 0.05) and at last follow-up visit (118+/-6.2 vs. 223+/-63, P < 0.03) for groups A and B, respectively. The graft survival in group A was significantly higher than that in group B (100% vs. 87% at 1 year, P < 0.05). The graft functional reserve was significantly better in group A than in group B. Post-transplant proteinuria was significantly more frequent in group B recipients (70% vs. 40%, P < 0.03). The age of the donors had no impact on the incidence of post-transplant hypertension. These observations suggest that the transplantation of a kidney from an older live kidney donor is associated with an inferior post-transplant outcome.
authors: Urology and Nephrology Center, University of Mansoura, Mansoura, Egypt.
authors: M
authors: M
authors: Sobh
authors: A
authors: A
authors: el-Salam Yousif
authors: A
authors: A
authors: Shokeir
authors: A
authors: A
authors: Shaaban
authors: M
authors: M
authors: Kenawy
authors: A
authors: A
authors: el-Sherif
authors: M
authors: M
authors: Ghoneim
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003404:Creatinine / Q000378:metabolism; D005190:Family; D005260:Female; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D019520:Living Donors / Q000706:statistics & numerical data*; D008297:Male; D010290:Parents; D018579:Patient Selection; D035781:Siblings; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D003404:Creatinine