Surface modification of poly(dimethylsiloxane) microchannels.
This review looks at the efforts that are being made to modify the surface of poly(dimethylsiloxane) (PDMS) microchannels, in order to enhance applicability in the field of microfluidics. Many surface modifications of PDMS have been performed for electrophoretic separations, but new modifications are being done for emerging applications such as heterogeneous immunoassays and cell-based bioassays. These new modification techniques are powerful because they impart biospecificity to the microchannel surfaces and reduce protein adsorption. Most of these applications require the use of aqueous or polar solvents, which makes surface modification a very important topic.
Makamba
Honest
H
National Research Laboratory for Advanced Biotechnology and Biomedical Microinstrumentation, Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, South Korea.
Kim
Jin Ho
JH
Lim
Kwanseop
K
Park
Nokyoung
N
Hahn
Jong Hoon
JH
D000327:Adsorption; D004129:Dimethylpolysiloxanes; D008051:Lipid Bilayers; D008567:Membranes, Artificial; D008904:Miniaturization / Q000379:methods; D011506:Proteins / Q000032:analysis; D012828:Silicones; D013499:Surface Properties
D004129:Dimethylpolysiloxanes; D008051:Lipid Bilayers; D008567:Membranes, Artificial; D011506:Proteins; D012828:Silicones; C013830:baysilon