Regulation of tissue factor-factor VIIa expression on cell surfaces: a role for tissue factor-factor VIIa endocytosis.
Tissue factor (TF) is the cellular receptor for plasma clotting factor VIIa (FVIIa) and the formation of TF-VIIa complexes on cell surfaces triggers the coagulation cascade. Further, TF-VIIa, either directly or indirectly, influences various biological processes, such as development, inflammation and tumor metastasis. Therefore, a proper regulation of TF-VIIa expression is critical for the maintenance of hemostatic balance and health in general. TF-VIIa functional expression on cell surfaces is regulated primarily by transcriptional regulation of TF gene or by specific plasma inhibitors, particularly tissue factor pathway inhibitor (TFPI). However, a number of other mechanisms that are yet to be well defined also regulate TF-VIIa functional expression. One such mechanism is the endocytosis of TF-VIIa. In this article, we provide a comprehensive review on the regulation of TF-VIIa functional expression by these other mechanisms, with a particular emphasis on TF-VIIa endocytosis, and our perspective of these studies.
Rao
L Vijaya Mohan
LV
Biomedical Research, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA. Vijay.Rao@uthct.edu
Pendurthi
Usha R
UR
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D019281:Dimerization; D004705:Endocytosis / Q000502:physiology*; D015942:Factor VIIa / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D020286:Pericytes / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D013925:Thromboplastin / Q000378:metabolism*
D008074:Lipoproteins; D010743:Phospholipids; C051928:lipoprotein-associated coagulation inhibitor; D013925:Thromboplastin; D015942:Factor VIIa