title: Expressions of vascular endothelial growth factor in cirrhotic tissues and their relations to proto-oncogene c-fos, c-myc.
abstract: OBJECTIVE
  To investigate the significance of vascular endothelial growth factor (VEGF) in the pathogenesis of liver cirrhosis and the correlation between VEGF and proto-oncogene c-fos and c-myc in cirrhotic liver.
  
  
  METHODS
  The proteins of VEGF, c-fos, and c-myc were identified immunohistochemically in each tissue section of 53 cases of liver cirrhosis. The correlations between VEGF, c-fos and c-myc were analyzed. The levels of VEGF protein in different Child gradings were also compared.
  
  
  RESULTS
  The proteins of VEGF were more highly expressed in Child A and B patients than in Child C patients and controls. The expressions of both c-fos and c-myc were not statistically significant between VEGF positive and negative patients.
  
  
  CONCLUSIONS
  The protein level of VEGF can reflect the compensation status of cirrhosis patients and may act as an anti-cirrhotic factor. The proto-oncogene c-fos, c-myc and VEGF may have different mechanisms in the course of cirrhosis or hepatic tumorigenesis.
authors: Department of General Surgery, Shandong Provincial Hospital, Jinan 250021, China. baomins@163.net
authors: Bao-Min
authors: BM
authors: Shi
authors: Xiu-Yan
authors: XY
authors: Wang
authors: Qing-Ling
authors: QL
authors: Mu
authors: Tai-Huang
authors: TH
authors: Wu
authors: Zhen
authors: Z
authors: Yang
authors: Li
authors: L
authors: Zhang
authors: Da-Peng
authors: DP
authors: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008103:Liver Cirrhosis / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000090063:Proto-Oncogene Mas; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D013194:Staining and Labeling; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D016760:Proto-Oncogene Proteins c-fos; D016271:Proto-Oncogene Proteins c-myc; D042461:Vascular Endothelial Growth Factor A