title: Relation of fasting insulin related to insertion/deletion polymorphism of angiotensin-converting enzyme-gene and cardiac mass in never-treated patients with systemic hypertension.
abstract: Left ventricular (LV) mass that develops as cardiac adaptive remodeling represents a powerful independent predictor of cardiovascular morbidity and mortality in the general population and in several clinical conditions, including essential hypertension. However, many studies have shown that blood pressure explains only 10% to 25% of the variation in LV mass, supporting the hypothesis that other factors, such as genetics or metabolics (insulin-resistance/hyperinsulinemia), are involved in the cardiac growth in human hypertension. Essential hypertension is also characterized by insulin-resistance/hyperinsulinemia, which may directly induce LV hypertrophy through the stimulation of insulin-like growth factor-1 receptors, abundantly expressed in myocardium. Taken together, we investigated the growth effect of fasting insulin, associated with angiotensin-converting enzyme-gene polymorphism, on cardiac mass in a group of previously untreated hypertensive patients.
authors: Cardiovascular Diseases Unit, Department of Experimental and Clinical Medicine G. Salvatore, University Magna Graecia of Catanzaro, Catanzaro, Italy.
authors: Roberto
authors: R
authors: Ceravolo
authors: Raffaele
authors: R
authors: Maio
authors: Giovanni
authors: G
authors: Cuda
authors: Angela
authors: A
authors: Scozzafava
authors: Angela
authors: A
authors: Sciacqua
authors: Marco
authors: M
authors: Vatrano
authors: Giancarlo
authors: G
authors: Bellieni
authors: Gianfranco
authors: G
authors: D'Angelo
authors: Francesco A
authors: FA
authors: Schipani
authors: Giorgio
authors: G
authors: Sesti
authors: Francesco
authors: F
authors: Perticone
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D005215:Fasting / Q000097:blood*; D005260:Female; D017353:Gene Deletion; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology*; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016254:Mutagenesis, Insertional / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D012083:Renin / Q000235:genetics*
chemical_list: D000959:Antihypertensive Agents; D007328:Insulin; D012083:Renin