Chromatin dynamics: nucleosomes go mobile through twist defects.
We study the spontaneous "sliding" of histone spools (nucleosomes) along DNA as a result of thermally activated single base pair twist defects. To this end we map the system onto a suitably extended Frenkel-Kontorova model. Combining results from several recent experiments we are able to estimate the nucleosome mobility without adjustable parameters. Our model shows also how the local mobility is intimately linked to the underlying base pair sequence.
Kulić
I M
IM
Max-Planck-Institut für Polymerforschung, Theory Group, PO Box 3148, D 55021 Mainz, Germany.
Schiessel
H
H
D002843:Chromatin / Q000737:chemistry* / Q000235:genetics; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D006657:Histones / Q000737:chemistry / Q000235:genetics; D009690:Nucleic Acid Conformation; D009707:Nucleosomes / Q000737:chemistry* / Q000235:genetics
D002843:Chromatin; D006657:Histones; D009707:Nucleosomes; D004247:DNA