title: Multifocal fibrosclerosis: retroperitoneal fibrosis associated with a suprasellar tumor and pachymeningitis.
abstract: A 42 year-old man with lumbago and fever had hydronephrosis due to a mass surrounding the abdominal aorta, associated with pachymeningitis and a suprasellar tumor. He was given a diagnosis of multifocal fibrosclerosis, involving both retroperitoneal and intracranial fibrosis. He responded to treatment with corticosteroid and cyclophosphamide. The intracranial lesions seemed to be rare, but important manifestations of the systemic disease, and were clearly visualized by magnetic resonance imaging. The phenotype of the infiltrated lymphocytes was CD4+, supporting the hypothesis that autoimmunity was involved pathogenetically. We propose a comprehensive category termed "inflammatory fibrotic disease" including both systemic and localized diseases.
authors: Department of Internal Medicine, Kyoto Second Red-Cross Hospital, Kyoto.
authors: Wataru
authors: W
authors: Fukuda
authors: Mizuho
authors: M
authors: Kimura
authors: Teruaki
authors: T
authors: Akaogi
authors: Masami
authors: M
authors: Sako
authors: Kaiyo
authors: K
authors: Ohiwa
authors: Yasumasa
authors: Y
authors: Yamamoto
authors: Genichi
authors: G
authors: Kato
authors: Hideo
authors: H
authors: Hayashi
authors: Toshikazu
authors: T
authors: Yoshikawa
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D008297:Male; D008581:Meningitis / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D012185:Retroperitoneal Fibrosis / Q000150:complications* / Q000175:diagnosis / Q000628:therapy