Absolute configuration of the thyroid hormone analog KAT-2003 as determined by the 1H NMR anisotropy method with a novel chiral auxiliary, MalphaNP acid.
The absolute configuration of the chiral thyroid hormone analog KAT-2003 (+)-2, showing hypocholesterolemic activities, decreases of hepatic triglyceride contents with lowering cardiac side effects, and significant inhibitory effect for the second primary hepatocellular carcinoma, was determined as S by the (1)H NMR anisotropy method using a novel chiral auxiliary, 2-methoxy-2-(1-naphtyl)propionic acid (MalphaNP acid).
Nishimura
Toshihiro
T
Central Research Laboratories, Kissei Pharmaceutical Co., Nagano-Pref., Japan.
Taji
Hiromi
H
Harada
Nobuyuki
N
D000818:Animals; D016880:Anisotropy; D000924:Anticholesteremic Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011422:Propionates; D013237:Stereoisomerism; D014284:Triiodothyronine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
D000924:Anticholesteremic Agents; D000970:Antineoplastic Agents; D011422:Propionates; D014284:Triiodothyronine