p23, a simple protein with complex activities.
p23 is a small but important cochaperone for the Hsp90 chaperoning pathway. It appears to facilitate the adenosine triphosphate-driven cycle of Hsp90 binding to client proteins. It enters at a late stage of the cycle and enhances the maturation of client proteins. Although this role of p23 is fairly well established, recent studies suggest that it may have additional functions in the cell that merit further exploration.
Felts
Sara J
SJ
Department of Biochemistry and Molecular Biology, Mayo Graduate School, Rochester, MN 55905, USA.
Toft
David O
DO
D000818:Animals; D015966:Gene Expression Regulation, Fungal; D018841:HSP90 Heat-Shock Proteins / Q000378:metabolism; D019746:Intramolecular Oxidoreductases; D008322:Mammals / Q000235:genetics / Q000378:metabolism; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism*; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D000071876:Prostaglandin-E Synthases; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism
D018841:HSP90 Heat-Shock Proteins; D018832:Molecular Chaperones; D010750:Phosphoproteins; D019746:Intramolecular Oxidoreductases; D000071876:Prostaglandin-E Synthases