title: Behavioral and neurofunctional changes over time in healthy and aphasic subjects: a PET Language Activation Study.
abstract: OBJECTIVE
  Follow-up neuroimaging studies of aphasia never addressed a comparison between aphasic and healthy subjects. Investigation of changes over time in healthy subjects during language tasks seems a prerequisite before interpretation of longitudinal changes in aphasic patients.
  
  
  METHODS
  Six healthy subjects and 8 aphasic patients were PET scanned twice (PET1 and PET2) at a 1-year interval during a word generation task. Using SPM99, language-rest main effect was compared at PET1 and PET2 in each group, whereas group effect was assessed at each session. Correlations were analyzed in each group between performance indexes and changes in regional cerebral flood flow (rCBF) between the 2 sessions.
  
  
  RESULTS
  Language performances were improved in both groups. rCBF decreased from PET1 to PET2 in the healthy group and increased in the aphasic group in perisylvian regions bilaterally. Correlations between performance and rCBF changes across sessions were similar in the 2 groups; positive correlations involved superior temporal cortexes bilaterally, and negative correlations concerned superior frontal and medial temporal regions.
  
  
  CONCLUSIONS
  Increased perisylvian activation over time probably reflects improved performance at the expenses of cognitive effort in aphasic patients. Decreased activation in different neural systems suggests a familiarization effect with reduced emotional load.
authors: INSERM U455, PET Centre, University Hospital Purpan, Toulouse, France. cardebat@toulouse.inserm.fr
authors: Dominique
authors: D
authors: Cardebat
authors: Jean-François
authors: JF
authors: Démonet
authors: Xavier
authors: X
authors: De Boissezon
authors: Nathalie
authors: N
authors: Marie
authors: Rose-Marie
authors: RM
authors: Marié
authors: Jany
authors: J
authors: Lambert
authors: Jean-Claude
authors: JC
authors: Baron
authors: Michèle
authors: M
authors: Puel
mesh_terms: D000328:Adult; D000368:Aged; D001037:Aphasia / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D018450:Disease Progression; D005260:Female; D006801:Humans; D007807:Language Tests; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D012016:Reference Values; D013995:Time; D014705:Verbal Behavior