Mitochondrial bioenergetics, aging, and aging-related disease.
In this Perspective, the author discusses some of the bioenergetic consequences of the various alterations in mitochondrial function that have been hypothesized to be associated with human aging and aging-related disease. Special focus is afforded to neurodegenerative disease.
Nicholls
David
D
Buck Institute for Age Research, Novato, CA 94945, USA. dnicholls@buckinstitute.org
D000375:Aging / Q000473:pathology / Q000502:physiology*; D000818:Animals; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D007425:Intracellular Membranes / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000378:metabolism / Q000473:pathology