title: FolM, a new chromosomally encoded dihydrofolate reductase in Escherichia coli.
abstract: Escherichia coli (thyA DeltafolA) mutants are viable and can grow in minimal medium when supplemented with thymidine alone. Here we present evidence from in vivo and in vitro studies that the ydgB gene determines an alternative dihydrofolate reductase that is related to the trypanosomatid pteridine reductases. We propose to rename this gene folM.
authors: Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
authors: Moshe
authors: M
authors: Giladi
authors: Neta
authors: N
authors: Altman-Price
authors: Itay
authors: I
authors: Levin
authors: Liat
authors: L
authors: Levy
authors: Moshe
authors: M
authors: Mevarech
mesh_terms: D000595:Amino Acid Sequence; D001708:Biopterins / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology*; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D016415:Sequence Alignment; D013762:Tetrahydrofolate Dehydrogenase / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D013763:Tetrahydrofolates / Q000378:metabolism
chemical_list: D029968:Escherichia coli Proteins; D013763:Tetrahydrofolates; D001708:Biopterins; C030371:5,6,7,8-tetrahydrofolic acid; C479919:FolM protein, E coli; D013762:Tetrahydrofolate Dehydrogenase