[The epigenetic code of histones].
It has become clear that post-translational modifications of histones are key players in the mechanisms of transcriptional regulation. There are 4 major types of histone modifications: acetylation, methylation, phosphorylation and ubiquitinylation. Different combinations of these modifications would form an epigenetic code which, once read by specific protein domains, would lead to diverse responses at precise locations within the eukaryotic genome.
Lacoste
Nicolas
N
Centre de recherche en cancérologie de l'Université Laval, Hôtel-Dieu de Québec (CHUQ), 9, rue McMahon, Québec, G1R 2J6, Canada.
Côté
Jacques
J
D044127:Epigenesis, Genetic; D006657:Histones / Q000235:genetics*; D006801:Humans; D008745:Methylation; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D014452:Ubiquitins / Q000378:metabolism
D006657:Histones; D014452:Ubiquitins