title: [Biologically active substances from medicinal plants as a factor of the organism detoxication].
abstract: Reported detail analysis of reguirements to the multicomponents plant systems for detoxication and cleaning of stomach and intestinal tract including absorption of harmful compounds, compensation of losses of benefit micronutrients, antiinflamatory, antiucler, anticancer activity, increase local immunity, activation of intestinal endocrinocytes, antioxidative and antihypoxantive activity ets. Molecular mechanisms of body detoxication with participation of medicinal and food plants compounds are discussed. Its include influence of this compounds on a) biochemical mechanism of detoxication and elimination from tissues of hydrophobic xenobiotics, drugs and hydrophobic metabolits (microsomal monooxygenases--cytochrome P-450--dependent system) and enzymes of conjugation(glutathion--S-transferase, glucuronyltransferase etc.; b) on antioxidant system (enzymatic superoxidedismutase-glutathionperoxidase and catalase seguence) and nonenzymatic chains (influence of flavonoids, anticyanines, antioxidant vitamins etc.)
authors: V A
authors: VA
authors: Dadali
authors: V G
authors: VG
authors: Makarov
mesh_terms: D000975:Antioxidants / Q000378:metabolism / Q000493:pharmacokinetics; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004064:Digestive System / Q000187:drug effects; D004068:Digestive System Physiological Phenomena; D004232:Diuretics / Q000494:pharmacology; D004798:Enzymes / Q000378:metabolism*; D014453:Glucuronosyltransferase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000187:drug effects; D008658:Inactivation, Metabolic; D009369:Neoplasms / Q000517:prevention & control; D010946:Plants, Medicinal; D015262:Xenobiotics / Q000493:pharmacokinetics
chemical_list: D000975:Antioxidants; D004232:Diuretics; D004798:Enzymes; D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase