Anti-inflammatory and antinociceptive activity of taxoids and lignans from the heartwood of Taxus baccata L.
Four taxoids (taxusin, baccatin VI, baccatin III and 1beta-hydroxybaccatin I) and five lignans (lariciresinol, taxiresinol, 3'-demethylisolariciresinol-9'-hydroxyisopropylether, isolariciresinol and 3-demethylisolariciresinol) were isolated from the heartwood of Taxus baccata L. (Taxaceae) growing in Turkey through chromatographic techniques. In vivo anti-inflammatory and antinociceptive activity of these compounds were investigated. All the compounds were shown to possess significant antinociceptive activity against p-benzoquinone-induced abdominal contractions, while only lignan derivatives significantly inhibited carrageenan-induced hind paw edema in mice.
Küpeli
Esra
E
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 6330, Ankara, Turkey.
Erdemoğlu
Nurgün
N
Yeşilada
Erdem
E
Sener
Bilge
B
D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D016227:Benzoquinones; D002351:Carrageenan; D003085:Colic / Q000139:chemically induced / Q000188:drug therapy; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D043823:Taxoids / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D020946:Taxus / Q000737:chemistry*; D023382:Toxicity Tests, Acute
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D016227:Benzoquinones; D017705:Lignans; D010936:Plant Extracts; D043823:Taxoids; C004532:quinone; D002351:Carrageenan