title: Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials.
abstract: Novel benzazepine oxazolidinone antibacterials were synthesized and evaluated against clinically relevant susceptible and resistant organisms. The effect of ring nitrogen position and N-substitution on antibacterial activity is examined.
authors: Discovery-Chemistry, Pharmacia Corporation, 7000 Portage Road, Kalamazoo, MI 49001, USA. paul.d.johnson@pharmacia.com
authors: Paul D
authors: PD
authors: Johnson
authors: Paul A
authors: PA
authors: Aristoff
authors: Gary E
authors: GE
authors: Zurenko
authors: Ronda D
authors: RD
authors: Schaadt
authors: Betty H
authors: BH
authors: Yagi
authors: Charles W
authors: CW
authors: Ford
authors: Judith C
authors: JC
authors: Hamel
authors: Douglas
authors: D
authors: Stapert
authors: Judy K
authors: JK
authors: Moerman
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001552:Benzazepines / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D000069349:Linezolid; D051379:Mice; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D001552:Benzazepines; D023303:Oxazolidinones; D000069349:Linezolid