Decreased serum opsonic activity against Streptococcus pneumoniae in human immunodeficiency virus-infected Ugandan adults.
Type-specific immunoglobulin G (IgG) to pneumococcal capsular polysaccharide (CPS) and opsonic activity against Streptococcus pneumoniae were evaluated in serum samples from 36 Ugandan adults with community-acquired pneumonia and 58 asymptomatic Ugandan adults with or without human immunodeficiency virus type 1 (HIV-1) infection. The levels of serum IgG to CPS were significantly higher in HIV-1-infected subjects than in HIV-uninfected subjects. Serum samples from HIV-1-infected subjects that had lower IgG titers demonstrated higher opsonic activity against type 3 (titers of 7) and type 9 (titers of 7-11) pneumococcal strains. Plasma HIV-1 load also correlated inversely with serum opsonic activity against these strains, and peripheral blood CD4+ lymphocyte numbers also tended to correlate with serum opsonic activity in asymptomatic HIV-1-infected adults. Our findings suggest that the opsonic activity of type-specific IgG is impaired in the serum of HIV-1-infected African adults, which may expose them to a serious risk of invasive pneumococcal infections.
Takahashi
Hidehiko
H
Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, Japan.
Oishi
Kazunori
K
Yoshimine
Hiroyuki
H
Kumatori
Atsushi
A
Moji
Kazuhiko
K
Watanabe
Kiwao
K
Nalwoga
Hawa
H
Tugume
Sitefano Buguruka
SB
Kebba
Anthony
A
Mugerwa
Roy
R
Mugyenyi
Peter
P
Nagatake
Tsuyoshi
T
D000328:Adult; D006678:HIV; D015658:HIV Infections / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D009895:Opsonin Proteins / Q000097:blood / Q000378:metabolism*; D011008:Pneumococcal Infections / Q000150:complications / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology* / Q000502:physiology
D007074:Immunoglobulin G; D009895:Opsonin Proteins