title: Insulin-like growth factor-II gene polymorphism is associated with primary open angle glaucoma.
abstract: Hypoxia and ischemia play important roles in the onset and progression of glaucoma. Insulin-like growth factors (IGF) are important neurotrophic agents that respond to hypoxia-ischemia. In this study, we enrolled 60 primary open angle glaucoma (POAG) patients and 104 healthy volunteers from the China Medical College Hospital. Among the polymorphism of IGFs gene, exon 9 Apa I C/T gene polymorphism is the most frequently seen. The polymorphism was observed following polymerase chain reaction based restriction analysis used to to resolve the relationship between IGF-II exon 9 Apa I C/T gene polymorphism and POAG. The distribution of the IGF-II exon 9 gene polymorphism showed statistical differences in the distribution of genotype frequencies between POAG patients and normal controls (P=0.010). The odds ratio of C/C homozygote was 0.266 (95% confidence interval=0.636 approximately 0.111). IGF-II is an important neurotrophic agent and regulates the suffering of POAG. C/C homozygote of IGF-II exon 9 Apa I C/T gene polymorphism is a useful marker of POAG in Chinese.
authors: Department of Medical Genetics and Pediatrics, China Medical University Hospital, Taichung, Taiwan.
authors: Fuu-Jen
authors: FJ
authors: Tsai
authors: Hui-Ju
authors: HJ
authors: Lin
authors: Wen-Chi
authors: WC
authors: Chen
authors: Huey-Yi
authors: HY
authors: Chen
authors: Seng-Sheen
authors: SS
authors: Fan
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D004247:DNA / Q000032:analysis; D005260:Female; D020022:Genetic Predisposition to Disease; D005902:Glaucoma, Open-Angle / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D006785:Hospitals, University; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D007335:Insulin-Like Growth Factor II; D004247:DNA