title: Longitudinal association between sex hormone levels, bone loss, and bone turnover in elderly men.
abstract: Male osteoporosis is an increasingly important health problem. It is known that sex steroid hormones play an important role in regulating bone turnover and bone mass in males as well as in females. However, the exact mechanism of bone loss in men remains unknown. In the present study, 200 elderly men (age range, 55-85 yr) were followed for 4 yr to evaluate the relationships between hormone levels, bone turnover markers, bone mineral density, and rates of bone loss. Femoral and lumbar bone mineral density, bone ultrasound parameters at the os calcis, serum testosterone (T), serum estradiol (E(2)), SHBG levels, and bone turnover markers (urinary crosslaps and bone alkaline phosphatase) were evaluated for each man at enrollment and 4 yr afterward. The free androgen index (FAI) and free estrogen index (FEI) as well as measures of the bioavailable sex hormones [calculated bioavailable E(2) (c-bioE(2)) and T (c-bioT)] were calculated from total hormone levels and SHBG. In the total population, T, c-bioT, c-bioE(2), FAI, and FEI, but not E(2), decreased significantly with age, whereas SHBG increased significantly. Subjects with FEI, c-bioE(2), and E(2) levels below the median showed higher rates of bone loss at the lumbar spine and the femoral neck as well as higher speed-of-sounds decrease at the calcaneus with respect to men with FEI, c-bioE(2), and E(2) levels above the median. Serum bone alkaline phosphatase and urinary crosslaps were significantly higher in men with FEI, c-bioE(2), and E(2) in the lower quartile than in men with FEI, c-bioE(2), and E(2) levels in the higher quartile. No statistically significant differences were observed in relation to T, c-bioT, or FAI levels. Finally, the ratio between E(2) and T, an indirect measure for aromatase activity, increased significantly with age and was higher in normal than in osteoporotic subjects. In conclusion, results from the present study indicate an important role of estrogens, and particularly of the ability to aromatize T to E(2), in the regulation of bone loss and bone metabolism in elderly men.
authors: Department of Internal Medicine, Endocrine-Metabolic Sciences and Biochemistry, University of Siena, 53100 Siena, Italy. gennari@unisi.it
authors: Luigi
authors: L
authors: Gennari
authors: Daniela
authors: D
authors: Merlotti
authors: Giuseppe
authors: G
authors: Martini
authors: Stefano
authors: S
authors: Gonnelli
authors: Beatrice
authors: B
authors: Franci
authors: Stella
authors: S
authors: Campagna
authors: Barbara
authors: B
authors: Lucani
authors: Norberto
authors: N
authors: Dal Canto
authors: Roberto
authors: R
authors: Valenti
authors: Carlo
authors: C
authors: Gennari
authors: Ranuccio
authors: R
authors: Nuti
mesh_terms: D000368:Aged; D015519:Bone Density; D001862:Bone Resorption / Q000097:blood; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D004958:Estradiol / Q000097:blood; D005272:Femur Neck / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D008137:Longitudinal Studies; D008159:Lumbar Vertebrae / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood
chemical_list: D012739:Gonadal Steroid Hormones; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate