[Dynamics of immunologic indices in patients with ischemic heart disease on a course of doxazosin therapy].
The authors have studied effects of the course treatment with doxasosine, a selective alpha 1-adrenoblocker, on lipid and immunological indices in 46 male subjects with ischemic heart disease presenting with functional class I-III exertional angina. A significant improvement in indices for lipid metabolism has been shown together with absence of negative influence on parameters characterizing immunologic vigour with no worsening of manifestations of T-cellular immune deficiency. In hypercholesterinemia-free middle-aged subjects, posttreatment alterations in the peripheral blood can be regarded as a result of a positive effect on immunological reactivity.
Lyzohub
V H
VH
Savchenko
O V
OV
Chumak
A A
AA
Dykukha
I S
IS
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000787:Angina Pectoris / Q000097:blood / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D017292:Doxazosin / Q000627:therapeutic use*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000188:drug therapy* / Q000276:immunology* / Q000503:physiopathology; D005082:Physical Exertion / Q000187:drug effects; D014280:Triglycerides / Q000097:blood
D000317:Adrenergic alpha-Antagonists; D008055:Lipids; D014280:Triglycerides; D017292:Doxazosin