[Influence of the indometafen radioprotector on the immune reactivity].
In the experiments on dogs and mice it was shown that indometophene could modify the immune status of the body. Specific and non-specific resistance of mice to E. coli infection increased after indometophene administration. At the same time higher titers of normal anti-salmonella antibodies in mice serum and a higher phagocytic activity of neutrophils in the peripheral blood in dogs were found. The influence of the preparation on the content of the complement and normal antibodies-hemagglutinins was less pronounced. It was suggested that the indometophene ability to bustle immune reactivity of the body played a certain role in the mechanism of its radioprotective effect.
Mikhaĭlov
P P
PP
State Research Center-Institute of Biophysics, Russian Ministry of Health, Moscow, 123182 Russia.
Mal'tsev
V N
VN
Shliakova
T G
TG
Khaustova
L I
LI
Romanova
S V
SV
Skachkova
V G
VG
Arsent'eva
L G
LG
D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis; D003692:Delayed-Action Preparations; D004285:Dogs; D004927:Escherichia coli Infections / Q000276:immunology / Q000517:prevention & control; D005260:Female; D006388:Hemagglutinins / Q000032:analysis; D007110:Immunity, Active / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011837:Radiation-Protective Agents / Q000494:pharmacology; D012475:Salmonella / Q000276:immunology; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013997:Time Factors
D000907:Antibodies, Bacterial; D003692:Delayed-Action Preparations; D006388:Hemagglutinins; D011837:Radiation-Protective Agents; C091454:indometafen; D013629:Tamoxifen; D003165:Complement System Proteins