A novel t(2;6)(p12;q23) appearing during transformation of follicular lymphoma with t(18;22)(q21;q11) to diffuse large cell lymphoma.
Follicular lymphoma is characterized genetically by t(14;18)(q32;q21), whereas t(18;22)(q21;q11), a rare variant form of t(14;18), has been preferentially observed in chronic lymphocytic leukemia (CLL). We describe here an unusual case of follicular lymphoma with a t(18;22)(q21;q11), that progressed to diffuse large cell lymphoma with a novel t(2;6)(p12;q23). Spectral karyotyping revealed that add(2)(p12) and add(6)(q23) were derived from a t(2;6)(p12;q23). Fluorescence in situ hybridization analysis confirmed rearrangements of the BCL2 gene at 18q21 and the BCL6 gene at 3q27. Our results indicate that a reciprocal translocation involving 6q23 could be implicated in the progression of follicular lymphoma and that t(18;22) may have a specific role in the pathogenesis of follicular lymphoma as well as CLL.
Yamamoto
Katsuya
K
Division of Hematology/Oncology, Department of Medicine, Kobe University School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
Okamura
Atsuo
A
Minagawa
Kentaro
K
Yakushijin
Kimikazu
K
Urahama
Norinaga
N
Gomyo
Hiroshi
H
Shimoyama
Manabu
M
Itoh
Mitsuhiro
M
Matsui
Toshimitsu
T
D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002887:Chromosomes, Human, Pair 18; D002889:Chromosomes, Human, Pair 2; D002892:Chromosomes, Human, Pair 22; D002896:Chromosomes, Human, Pair 6; D020732:Cytogenetic Analysis; D018450:Disease Progression; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008224:Lymphoma, Follicular / Q000235:genetics*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic