title: Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation.
abstract: BACKGROUND
  The aim of the present study was to investigate the effect of a probiotic beverage on gastrointestinal symptoms in patients with chronic constipation.
  
  
  METHODS
  A double-blind, placebo-controlled, randomized study was conducted over a four-week period in patients with symptoms of chronic constipation (n=70). To all patients, 65 mL/day of a probiotic beverage containing Lactobacillus casei Shirota (LcS) or a sensorially identical placebo was administered. Patients completed a questionnaire on gastrointestinal symptoms, well-being and stool habits and underwent a medical examination weekly. Severity of constipation, flatulence and bloating was summarized into four categories (severe, moderately severe, mild and no symptoms).
  
  
  RESULTS
  The consumption of LcS resulted in a significant improvement in self-reported severity of constipation and stool consistency, starting in the second week of the intervention phase (P<0.0001). Severe and moderately severe constipation was observed less in the LcS group. The occurrence and degree of flatulence or bloating sensation did not change. In the final examination, 89% of the LcS group and 56% of the placebo group showed a positive effect of their beverage on constipation (P=0.003). No adverse reactions were reported.
  
  
  CONCLUSIONS
  The results indicate a beneficial effect on gastrointestinal symptoms of patients with chronic constipation. The administration of probiotic foodstuffs may be recommended as an adjunctive therapy of chronic constipation.
authors: Department of Interventional Studies, German Institute of Human Nutrition, Bergholz-Rehbrücke, Germany. Koebnick@mail.dife.de
authors: Corinna
authors: C
authors: Koebnick
authors: Irmtrud
authors: I
authors: Wagner
authors: Peter
authors: P
authors: Leitzmann
authors: Udo
authors: U
authors: Stern
authors: H J Franz
authors: HJ
authors: Zunft
mesh_terms: D000328:Adult; D001628:Beverages; D003248:Constipation / Q000628:therapy*; D003672:Defecation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007780:Lacticaseibacillus casei; D008297:Male; D019936:Probiotics / Q000627:therapeutic use*