Intratympanic steroids: do they acutely improve hearing in cases of cochlear hydrops?
OBJECTIVE
To study the acute effects on hearing of intratympanic dexamethasone in patients with cochlear hydrops.


METHODS
Retrospective review.


METHODS
Patients who met established criteria for the diagnosis of Ménière's disease or had a history of fluctuating hearing loss and met hearing loss criteria for Ménière's disease, indicating cochlear hydrops, underwent a series of one to three intratympanic injections of dexamethasone in the affected ear. Follow-up audiograms were obtained 1 week after each injection and, in many patients, several months after injection.


RESULTS
Fifty patients met inclusion criteria and were studied. Using the American Academy of Otolaryngology-Head and Neck Surgery reporting guidelines, hearing improved acutely in 20 of the 50 patients (40%), was worse in 2 (4%), and did not change in 28 (56%). For those who improved, the average decrease in threshold was 14.2 dB. Whether the patient had typical Ménière's disease or cochlear hydrops did not affect the response to therapy. There were no significant complications from the injections.


CONCLUSIONS
Intratympanic administration of dexamethasone may acutely affect sensorineural hearing loss associated with endolymphatic hydrops. A prospective, controlled study is required.
Hillman
Todd M
TM
Pittsburgh Ear Associates, Pennsylvania 15212-4746, USA.
Arriaga
Moises A
MA
Chen
Douglas A
DA
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold / Q000502:physiology; D003051:Cochlea / Q000503:physiopathology*; D003907:Dexamethasone / Q000008:administration & dosage / Q000627:therapeutic use*; D018159:Endolymphatic Hydrops / Q000150:complications / Q000175:diagnosis; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000150:complications* / Q000175:diagnosis*; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013063:Speech Discrimination Tests; D013067:Speech Perception; D014432:Tympanic Membrane
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone