title: The non-classical export routes: FGF1 and IL-1alpha point the way.
abstract: Non-classical protein release independent of the ER-Golgi pathway has been reported for an increasing number of proteins lacking an N-terminal signal sequence. The export of FGF1 and IL-1alpha, two pro-angiogenic polypeptides, provides two such examples. In both cases, export is based on the Cu2+-dependent formation of multiprotein complexes containing the S100A13 protein and might involve translocation of the protein across the membrane as a 'molten globule'. FGF1 and IL-1alpha are involved in pathological processes such as restenosis and tumor formation. Inhibition of their export by Cu2+ chelators is thus an effective strategy for treatment of several diseases.
authors: Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, Maine 04074, USA.
authors: Igor
authors: I
authors: Prudovsky
authors: Anna
authors: A
authors: Mandinova
authors: Raffaella
authors: R
authors: Soldi
authors: Cinzia
authors: C
authors: Bagala
authors: Irene
authors: I
authors: Graziani
authors: Matteo
authors: M
authors: Landriscina
authors: Francesca
authors: F
authors: Tarantini
authors: Maria
authors: M
authors: Duarte
authors: Stephen
authors: S
authors: Bellum
authors: Holly
authors: H
authors: Doherty
authors: Thomas
authors: T
authors: Maciag
mesh_terms: D000818:Animals; D015687:Cell Hypoxia / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D016220:Fibroblast Growth Factor 1 / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D008560:Membrane Fluidity / Q000502:physiology; D008961:Models, Structural; D009389:Neovascularization, Pathologic / Q000378:metabolism; D021382:Protein Sorting Signals / Q000502:physiology*; D021381:Protein Transport; D009418:S100 Proteins
chemical_list: D007375:Interleukin-1; D021382:Protein Sorting Signals; D009418:S100 Proteins; C511523:S100A13 protein, human; D016220:Fibroblast Growth Factor 1; D003300:Copper