[The inheritance of obsessive-compulsive disorders].
Obsessive-compulsive disorder is a chronic psychiatric disorder characterised by obsessions and/or compulsions. Genetic research into obsessive-compulsive disorder is significantly limited by the difficulty in clearly defining the disease. There are only a few good studies and the populations investigated are small. Family and twin studies have provided evidence for a genetic component in obsessive-compulsive disorders. Segregation analyses suggest Mendelian inheritance of a dominant allele. In addition to one gene with a major effect, genes with smaller effects also play a role.
Denys
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Universitair Medisch Centrum Utrecht, Rudolf Magnus Instituut voor Neurowetenschappen, afd. Psychiatrie, Postbus 85.500, 3508 GA Utrecht. d.a.j.p.denys@azu.nl
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D020090:Chromosome Segregation; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D020412:Multifactorial Inheritance; D009771:Obsessive-Compulsive Disorder / Q000235:genetics*