Chipping away at brain function: mining for insights with microarrays.
The impact of microarray studies on neurobiology has been limited because, with the exception of a few outstanding papers, most reports provide little more than lists of genes, often leaving the reader at a loss to understand which and how many of the identified transcripts will be true positives with significant biological impact. However, some recent papers have offered considerable biological insight by providing independent in vivo confirmation of the roles of candidate genes, offering a glimpse of the potential power of microarrays in neurobiological research.
Henry
Gilbert L
GL
Cold Spring Harbor Laboratory, 1 Bungtown Rd, Cold Spring Harbor, NY 11724, USA.
Zito
Karen
K
Dubnau
Josh
J
D000818:Animals; D001921:Brain / Q000502:physiology*; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D009422:Nervous System Diseases / Q000175:diagnosis* / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*