Dyslipidogenic microangiopathy in guinea pigs at early stages of atherogenesis.
We studied the effect of dyslipidemia on lipid metabolism, state of microcirculatory system, and morphological alterations in the aorta and liver of guinea pigs at the early stages of experimental atherogenesis. The important role of microcirculatory disorders in the development of regional pathology and atherosclerosis is confirmed. The proposed alimentary model can be used in the development of novel methods for prevention and treatment of atherosclerosis.
Bersenev
A V
AV
Department of Stem Cell Biotechnology, Institute of Transplantology and Artificial Organs, Ministry of Health of the Russian Federation, Moscow. a_bersenev@celltranspl.ru
Klimenko
E D
ED
Kobozeva
L P
LP
Michunskaya
A B
AB
Onishchenko
N A
NA
Pozdnyakov
O M
OM
D000818:Animals; D001011:Aorta / Q000033:anatomy & histology / Q000378:metabolism; D001161:Arteriosclerosis / Q000378:metabolism* / Q000473:pathology; D001808:Blood Vessels / Q000378:metabolism* / Q000473:pathology; D002791:Cholesterol, Dietary; D006168:Guinea Pigs / Q000502:physiology*; D006949:Hyperlipidemias / Q000378:metabolism* / Q000473:pathology; D050356:Lipid Metabolism; D008099:Liver / Q000033:anatomy & histology / Q000378:metabolism; D008297:Male; D008833:Microcirculation / Q000378:metabolism* / Q000473:pathology
D002791:Cholesterol, Dietary