Severe tacrolimus leukoencephalopathy after liver transplantation.
Tacrolimus is an immunosuppressive agent that can show a wide variety of neurologic side effects, including leukoencephalopathy. Although the prognosis is good-after cessation or dose reduction, complete recovery usually occurs-the differentiation with treatable diseases such as progressive multifocal encephalopathy can be difficult, making a stereotactic biopsy of the white matter lesion sometimes necessary. We describe the case of a 12-year-old girl with a severe, reversible tacrolimus-related leukoencephalopathy and only mild histopathologic abnormalities.
Schuuring
Janneke
J
Department of Neurology, University Medical Center Nijmegen, Nijmegen, the Netherlands.
Wesseling
Pieter
P
Verrips
Aad
A
D002648:Child; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D012720:Severity of Illness Index; D016559:Tacrolimus / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
D007166:Immunosuppressive Agents; D016559:Tacrolimus