title: Hemostatic regulators of tumor angiogenesis: a source of antiangiogenic agents for cancer treatment?
abstract: The maintenance of vascular integrity and control of blood loss are regulated by a sophisticated system of circulating and cell-associated hemostatic factors. These factors control local platelet aggregation, the conversion of soluble fibrinogen to an insoluble fibrin polymer, and the dissolution of fibrin. However, hemostatic factors are also involved in a number of physiologic processes, including development, tissue remodeling, wound repair, reproduction, inflammation, and angiogenesis. In this review, we outline ways in which angiogenesis is coordinated with and regulated by hemostasis. We focus on inhibitors of angiogenesis contained within platelets or harbored as cryptic fragments of hemostatic proteins and assess the experimental and preclinical evidence for their ability to inhibit tumor angiogenesis and, thus, their potential to be anticancer agents. Finally, we review the results of recent clinical trials involving angiogenesis inhibitors and the evidence that antiangiogenic therapy may be associated with hemostatic complications.
authors: Academic Unit of Hematology, School of Medicine and Biomedical Sciences, Sheffield, United Kingdom.
authors: Martina E
authors: ME
authors: Daly
authors: Andreas
authors: A
authors: Makris
authors: Malcolm
authors: M
authors: Reed
authors: Claire E
authors: CE
authors: Lewis
mesh_terms: D020533:Angiogenesis Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D000818:Animals; D001779:Blood Coagulation Factors / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism; D002986:Clinical Trials as Topic; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D019679:Kininogen, High-Molecular-Weight / Q000378:metabolism; D009369:Neoplasms / Q000097:blood / Q000098:blood supply* / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000097:blood* / Q000188:drug therapy*; D018919:Neovascularization, Physiologic / Q000187:drug effects; D010949:Plasma / Q000378:metabolism
chemical_list: D020533:Angiogenesis Inhibitors; D001779:Blood Coagulation Factors; D019679:Kininogen, High-Molecular-Weight