RS-61443 reverses acute renal allograft rejection in dogs.
RS-61443 is a noncompetitive allosteric inhibitor of inosine monophosphate dehydrogenase. It blocks the proliferative response of T and B lymphocytes, prevents the generation of cytotoxic T cells, and inhibits antibody formation. This study was conducted to see whether or not RS-61443 can reverse acute renal allograft rejection in dogs. It was possible to reverse this process.
Platz
K P
KP
Department of Surgery, University of Wisconsin School of Medicine, Madison, Wisconsin 53792, USA.
Bechstein
W O
WO
Eckhoff
D E
DE
Hullett
D A
DA
Sollinger
H W
HW
D000208:Acute Disease; D000818:Animals; D004285:Dogs; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000276:immunology*; D008213:Lymphocyte Activation / Q000187:drug effects; D023421:Models, Animal; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013997:Time Factors; D014184:Transplantation, Homologous
D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid