title: In vitro modulation of the multiple sclerosis (MS)-associated retrovirus by cytokines: implications for MS pathogenesis.
abstract: Multiple sclerosis (MS)-associated retrovirus (MSRV) is a component of the human endogenous retrovirus (HERV)-W family, with gliotoxic and superantigenic properties, related to MS clinical progression, and transactivated by viral agents. The authors studied MSRV modulation by cytokines involved in vivo in MS course, utilizing peripheral blood mononuclear cells from MSRV-positive and MRSV-negative individuals. Cultured cells from MSRV-negative subjects did not produce virus, whereas spontaneous MSRV release was detected in cultures from MSRV-positive donors; virus release was increased by interleukin (IL)-4 and IL-6 and, to a greater extent, by the detrimental cytokines interferon gamma and tumor necrosis factor (TNF)alpha. Interferon beta, used in MS therapy, inhibits MSRV release. A parallel between the effects of these cytokines on MSRV production in vitro and on MS disease in vivo is observed, which deserves further elucidations.
authors: Section of Microbiology, Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
authors: Caterina
authors: C
authors: Serra
authors: Giuseppe
authors: G
authors: Mameli
authors: Giannina
authors: G
authors: Arru
authors: Stefano
authors: S
authors: Sotgiu
authors: Giulio
authors: G
authors: Rosati
authors: Antonina
authors: A
authors: Dolei
mesh_terms: D016207:Cytokines / Q000494:pharmacology*; D006801:Humans; D016899:Interferon-beta / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D015847:Interleukin-4 / Q000494:pharmacology; D015850:Interleukin-6 / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000821:virology; D009103:Multiple Sclerosis / Q000821:virology*; D012016:Reference Values; D012190:Retroviridae / Q000187:drug effects / Q000302:isolation & purification*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D016207:Cytokines; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; D016899:Interferon-beta; D007371:Interferon-gamma