Gastroprotection by coxibs: what do the Celecoxib Long-Term Arthritis Safety Study and the Vioxx Gastrointestinal Outcomes Research Trial tell us?
Current evidence suggests that PPIs might be effective in maintaining patients in remission during continued NSAID use and that the combination of omeprazole plus diclofenac is as effective as treatment with celecoxib in preventing recurrent bleeding. Larger outcome studies comparing the combination of a PPI with other nonselective NSAIDs and a selective COX-2 inhibitor (and the combination of a selective COX-2 inhibitor with a PPI or misoprostol) are required to determine whether or not any regimen will further decrease or eliminate the risk of ulcer complications in high-risk individuals.
Oviedo
Jaime A
JA
Section of Gastroenterology, Boston University School of Medicine, Boston Medical Center, 650 Albany Street, Boston, MA 02118-2393, USA.
Wolfe
M Michael
MM
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use*; D004008:Diclofenac / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D007783:Lactones / Q000009:adverse effects* / Q000627:therapeutic use*; D016595:Misoprostol / Q000494:pharmacology*; D009853:Omeprazole / Q000494:pharmacology*; D010003:Osteoarthritis / Q000188:drug therapy*; D054328:Proton Pump Inhibitors; D011720:Pyrazoles; D016032:Randomized Controlled Trials as Topic; D013449:Sulfonamides / Q000009:adverse effects* / Q000627:therapeutic use*; D013450:Sulfones
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D016861:Cyclooxygenase Inhibitors; D004791:Enzyme Inhibitors; D007783:Lactones; D054328:Proton Pump Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D013450:Sulfones; D016595:Misoprostol; C116926:rofecoxib; D004008:Diclofenac; D000068579:Celecoxib; D009853:Omeprazole