title: Leiomyosarcoma of the kidney in a dog.
abstract: A leiomyosarcoma that occurred in the right kidney of a dog (7-year-old female Labrador retriever) was studied pathologically. On histological examination, tumour cells were spindle-shaped, the cell density was high, and complex fasciculated tumour cells showing longitudinal and transverse cross-sections were observed. Both ends of the nuclei were rounded, the nucleoli were clear and many images of nuclear division were observed. Immunohistochemically, tumour cells reacted intensely with anti-vimentin antibody and anti-actin smooth muscle antibody, and mildly with anti-desmin antibody. On electron microscopy, the nuclei of tumour cells were rounded at both ends and elongated elliptically, and a large number of microfibrils with focal density and dense patches were observed in the cytoplasm. This is a case report of a very rare leiomyosarcoma of the dog kidney.
authors: Laboratory of Veterinary Pathology and Comprehensive Veterinary Clinical Studies, College of Bioresource Sciences, Nihon University, 1866 Kameino, Fujisawa, Kanagawa 252-8510, Japan. t-sato@brs.nihon-u.ac.jp
authors: T
authors: T
authors: Sato
authors: K
authors: K
authors: Aoki
authors: H
authors: H
authors: Shibuya
authors: T
authors: T
authors: Machida
authors: T
authors: T
authors: Watari
mesh_terms: D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D007668:Kidney / Q000648:ultrastructure; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000662:veterinary*; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000662:veterinary*; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D011860:Radiography, Abdominal / Q000662:veterinary; D014567:Urography / Q000662:veterinary