Semi-synthetic glycopeptide antibacterials.
Studies leading to the discovery of TD-6424 and their relevance to other hydrophobically-substituted glycopeptides are reviewed along with a brief comparison of properties for related agents currently undergoing clinical evaluation.
Judice
J Kevin
JK
Theravance, Inc., 901 Gateway Blvd., South San Francisco, CA 94080, USA. judice@gene.com
Pace
John L
JL
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D006020:Glycopeptides; D006801:Humans
D000900:Anti-Bacterial Agents; D006020:Glycopeptides