title: beta 1C Integrin expression in human endometrial proliferative diseases.
abstract: Integrins are ubiquitous cell adhesion molecules that are involved in maintaining normal tissue morphology and have been implicated in the aggressive behavior of several malignancies. beta 1C integrin is an alternatively spliced variant of the beta 1A integrin subunit that, at variance with beta 1A, inhibits epithelial cell proliferation. beta 1C integrin is expressed in non-proliferative, benign prostatic epithelium and is down-regulated in prostatic adenocarcinoma. In the current study, we examined beta 1C expression at mRNA and protein levels in 18 endometrial adenocarcinoma and in 20 endometrial hyperplastic tissues, using Northern and Western blotting analysis and immunohistochemistry. The pattern of integrin expression was compared to that of the endometrium of 14 normal cycling women. The results of this study document inhibited beta 1C integrin expression in endometrial adenocarcinoma, both at the mRNA and protein levels, at variance with significantly up-regulated beta 1C mRNA expression in endometrial hyperplasia, in comparison with normal proliferative endometria. Our data suggest a key role of the regulation of beta 1C integrin expression in the pathogenesis of endometrial proliferative diseases: beta 1C integrin may act as growth modulator in cancer cells, playing a role in downstream intracellular signaling.
authors: Institute of Biomembranes and Bioenergetics, National Research Council, Bari.
authors: Mariarosaria
authors: M
authors: Lovecchio
authors: Eugenio
authors: E
authors: Maiorano
authors: Rosa A
authors: RA
authors: Vacca
authors: Giuseppe
authors: G
authors: Loverro
authors: Margherita
authors: M
authors: Fanelli
authors: Leonardo
authors: L
authors: Resta
authors: Sergio
authors: S
authors: Stefanelli
authors: Luigi
authors: L
authors: Selvaggi
authors: Ersilia
authors: E
authors: Marra
authors: Elda
authors: E
authors: Perlino
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D045744:Cell Line, Tumor; D004714:Endometrial Hyperplasia / Q000378:metabolism*; D016889:Endometrial Neoplasms / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019012:Integrin beta1 / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D019012:Integrin beta1; D012333:RNA, Messenger; C403487:integrin beta1C