Levofloxacin-associated Achilles tendon rupture and tendinopathy.
Fluoroquinolones have a documented ability to induce Achilles tendinopathy. Hitherto, few published reports have implicated levofloxacin. This article reports 5 cases of Achilles tendon disorders, including 3 complicated by rupture of the tendon, during levofloxacin treatment of patients with chronic obstructive pulmonary disease.
Melhus
Asa
A
Department of Medical Microbiology, Malmö University Hospital, Malmö, Sweden. asa.melhus@mikrobiol.mas.lu.se
Apelqvist
Jan
J
Larsson
Jan
J
Eneroth
Magnus
M
D000125:Achilles Tendon / Q000293:injuries*; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D064704:Levofloxacin; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000009:adverse effects* / Q000627:therapeutic use; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D012421:Rupture / Q000139:chemically induced; D013708:Tendon Injuries / Q000139:chemically induced
D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin