title: Getting secretory granules ready for prime time.
abstract: Several rare human diseases have shed important light on the secretory pathway required for lymphocyte cytotoxicity. In this issue of Cell, Feldmann et al. identify mutations in Munc13-4 as a cause of familial hemophagocytic lymphohistiocytosis. Munc13-4 appears to be involved in the priming of cytotoxic granules prior to fusion with the plasma membrane.
authors: Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
authors: Bin
authors: B
authors: Zhang
authors: David
authors: D
authors: Ginsburg
mesh_terms: D000818:Animals; D015550:Cell Degranulation; D002462:Cell Membrane / Q000378:metabolism; D005089:Exocytosis; D015616:Histiocytosis, Non-Langerhans-Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008561:Membrane Fusion; D009154:Mutation; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D022142:Secretory Vesicles / Q000378:metabolism*; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000276:immunology
chemical_list: D011506:Proteins; C430713:Unc13d protein, rat