Approaches to the solid phase of a cyclotriveratrylene scaffold-based tripodal library as potential artificial receptors.
Two versatile tripodal cyclotriveratrylene (CTV)-based scaffolds (7 and 9) have been prepared for the solid phase construction of libraries of tripodal artificial synthetic receptors. A 2197-member library of CTV-based tripodal receptor molecules, 20[1-13,1-13,1-13], was prepared on the solid phase using split-mix synthesis. The CTV-based receptors contain three peptide arms; one of them is attached to the solid phase and is different from the other two identical peptide arms.
Chamorro
Cristina
C
Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands.
Liskamp
Rob M J
RM
D019151:Peptide Library; D018000:Receptors, Peptide / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*
D019151:Peptide Library; D018000:Receptors, Peptide