title: Coagulation monitoring and management of anticoagulation during cardiac assist device support.
abstract: BACKGROUND
  The incidence of clinically significant thromboembolic events due to the use of cardiac assist device systems remains high. Despite the considerable advances in cardiac assist device technology, the monitoring and management of the hypercoagulable coagulation status, resulting from foreign surfaces of the assist device system, altered rheologic conditions, and blood stasis in the recipient heart remain a challenge. Moreover septic complications and insufficient anticoagulation are responsible for thromboembolic events.
  
  
  METHODS
  In addition to standard coagulation analysis, functional coagulation tests were performed including the use of a thrombelastographic monitoring system (ROTEG) and a platelet function analyzer (PFA-100).
  
  
  RESULTS
  Severe biventricular ischemic heart failure developed in a 58-year-old man with acute myocardial infarction and he needed a biventricular assist device for a bridge to cardiac transplantation. Although the patient received acenocoumarol (Sintrom; Novartis Pharma, Vienna, Austria) and acetylsalicylic acid (Aspisol; Bayer AG, Leverkusen, Germany) as usual, ROTEG and the PFA-100 detected hypercoagulability while routine coagulation screening tests showed hypocoagulability. Moreover thrombus formation surrounding the canula of the left ventricular assist device was detected. Antithrombotic therapy with clopidogrel (Plavix) was initiated. Coagulation was closely monitored with modified thrombelastography and the PFA-100 to achieve sufficient but not overwhelming anticoagulation therapy. Three months after biventricular assist device implantation the patient underwent successful transplantation with no major blood loss.
  
  
  CONCLUSIONS
  Thrombelastography should be the standard form of monitoring in such patients to decrease the risk of thromboembolic events and prevent bleeding complications.
authors: Department of Anesthesia and Intensive Care Medicine, University of Innsbruck, Innsbruck, Austria. dietmar.fries@uibk.ac.at
authors: Dietmar
authors: D
authors: Fries
authors: Petra
authors: P
authors: Innerhofer
authors: Werner
authors: W
authors: Streif
authors: Wolfgang
authors: W
authors: Schobersberger
authors: Josef
authors: J
authors: Margreiter
authors: Herwig
authors: H
authors: Antretter
authors: Christoph
authors: C
authors: Hörmann
mesh_terms: D000074:Acenocoumarol / Q000008:administration & dosage; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000379:methods*; D000925:Anticoagulants / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage; D001777:Blood Coagulation / Q000502:physiology*; D001780:Blood Coagulation Tests; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D016027:Heart Transplantation; D006353:Heart-Assist Devices; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D009203:Myocardial Infarction / Q000175:diagnosis / Q000628:therapy*; D018570:Risk Assessment; D012720:Severity of Illness Index; D015607:Stents / Q000009:adverse effects; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D006493:Heparin; D000074:Acenocoumarol; D001241:Aspirin