title: A large fibrous polyp of the gallbladder mimicking a polypoid carcinoma.
abstract: Fibrous polyp of the gallbladder is a rare variant of benign gallbladder polyp. Differentiation between a benign polyp and polypoid carcinoma of the gallbladder is often difficult when the polyp is more than 1 cm in diameter. We report a rare case of a large fibrous polyp of the gallbladder mimicking a carcinoma. A 44-year-old Korean woman who presented with abdominal pain was diagnosed with a large gallbladder polyp, measuring 1.26 cm in diameter, by abdominal ultrasonography. The lesion was echogenic with a nodular surface on ultrasonography, and showed contrast enhancement on computed tomography. Neither evidence of infiltration into the gallbladder wall nor lymph node enlargement was shown. The resected gallbladder showed a 1.2 x 0.8-cm-sized polyp with a nodular surface. Histologically, it showed a leaf-like configuration and loose or cellular connective stroma containing scattered duct-like structures, varying-sized vessels, and patchy infiltration of chronic inflammatory cells. Stromal cells were immunoreactive for vimentin and smooth-muscle actin and negative for S-100 protein and desmin. Large fibrous polyps of the gallbladder should be considered in the differential diagnosis of benign and malignant polypoid lesions of the gallbladder.
authors: Department of Pathology, Sungkyunkwan University School of Medicine, Samsung Medical Center, 50 Irwon-dong, Gangnam-gu, 135-710, Seoul, Korea.
authors: Dong Hoon
authors: DH
authors: Kim
authors: Seong Rim
authors: SR
authors: Kim
authors: Sang Yong
authors: SY
authors: Song
authors: Jong Kyun
authors: JK
authors: Lee
authors: Jinseok
authors: J
authors: Heo
authors: Seung Hoon
authors: SH
authors: Kim
mesh_terms: D000328:Adult; D017081:Cholecystectomy, Laparoscopic; D003937:Diagnosis, Differential; D005260:Female; D005355:Fibrosis; D005704:Gallbladder / Q000000981:diagnostic imaging / Q000473:pathology*; D005706:Gallbladder Neoplasms / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D011127:Polyps / Q000175:diagnosis* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D018084:Ultrasonography, Interventional