title: Excess accumulation of body fat is related to dyslipidemia in normal-weight subjects.
abstract: OBJECTIVE
  To assess the relationship of fat mass (FM) and its distribution to hypertension and dyslipidemia in normal-weight Japanese individuals.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  Apparently healthy Japanese subjects with a body mass index (BMI) between 20 and 23.5 kg/m(2) (265 males and 741 females, age 21-69 y).
  
  
  METHODS
  BMI, waist circumference (WC), waist-hip ratio (WHR), systolic and diastolic blood pressure, serum levels of total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C) and triglyceride (TG) were measured. Low-density lipoprotein-cholesterol (LDL-C) was calculated by the Friedewald formula. Percentage fat mass (%FM) and trunk fat mass-leg fat mass ratio (FM(trunk)/FM(legs)) were obtained by dual-energy X-ray absorptiometry.
  
  
  RESULTS
  WC, WHR, %FM and FM(trunk)/FM(legs) were significantly correlated with TC, LDL-C, HDL-C and TG with the tendency of FM(trunk)/FM(legs) to show the strongest correlations. For %FM and FM(trunk)/FM(legs) in both sexes, odds ratios (ORs) of the third tertiles with respect to the first tertiles increased for LDL-C elevation, TG elevation and dyslipidemia. In males, ORs of the third tertiles of WC were significantly high for LDL-C elevation and dyslipidemia whereas those of WHR were high for TG elevation and dyslipidemia. ORs of the third tertiles of WC and WHR were significantly high for TG elevation in females. BMI was not associated with the risk of abnormal lipid levels. ORs for hypertension showed significant increases in none of the variables of obesity.
  
  
  CONCLUSIONS
  Excess accumulation of FM, especially to the upper body, was related to dyslipidemia in normal-weight subjects. Simple anthropometric variables, WC and WHR, may be useful for screening and management of dyslipidemia in these subjects.
authors: Fukuoka Health Promotion Foundation, Fukuoka, Japan. h_ito@intmed1.kyushu-u.ac.jp
authors: H
authors: H
authors: Ito
authors: K
authors: K
authors: Nakasuga
authors: A
authors: A
authors: Ohshima
authors: Y
authors: Y
authors: Sakai
authors: T
authors: T
authors: Maruyama
authors: Y
authors: Y
authors: Kaji
authors: M
authors: M
authors: Harada
authors: S
authors: S
authors: Jingu
authors: M
authors: M
authors: Sakamoto
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000473:pathology*; D000328:Adult; D000368:Aged; D000886:Anthropometry; D001824:Body Constitution; D015992:Body Mass Index; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000473:pathology*; D006973:Hypertension / Q000097:blood / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008078:Cholesterol, LDL; D014280:Triglycerides