title: Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones.
abstract: A novel series of oxazolidinones containing a pyrroloaryl substituent was synthesized and screened against a representative panel of susceptible and resistant Gram-positive bacteria. Several members of this series were found to have antibacterial activity comparable to or better than linezolid.
authors: Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Route 202, PO Box 300, Raritan, NJ 08869, USA. spaget@prdus.jnj.com
authors: Steven D
authors: SD
authors: Paget
authors: Barbara D
authors: BD
authors: Foleno
authors: Christine M
authors: CM
authors: Boggs
authors: Raul M
authors: RM
authors: Goldschmidt
authors: Dennis J
authors: DJ
authors: Hlasta
authors: Michele A
authors: MA
authors: Weidner-Wells
authors: Harvey M
authors: HM
authors: Werblood
authors: Ellyn
authors: E
authors: Wira
authors: Karen
authors: K
authors: Bush
authors: Mark J
authors: MJ
authors: Macielag
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid