Serum interferon inhibitor declines in patients with HIV-1 infection after a change in antiretroviral therapy.
An inhibitor of interferon antiviral activity, which is absent in healthy HIV-seronegative persons, was detected in the sera of all 29 HIV-seropositive study participants. The relationship of the level of interferon inhibitor to CD4 count and HIV-RNA copy number was statistically significant in distinct models. Levels of interferon inhibitor declined by an average of 41-60% in patients who underwent a change in anti-retroviral therapy. Interferon inhibitor levels appear to decline as CD4 cell count rises and HIV-RNA levels fall. This suggests that interferon inhibitor may have a significant role in the host immune response to HIV infection.
Chadha
Kailash C
KC
Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. kailash.chadha@roswellpark.org
Schwartz
Stanley A
SA
Nair
Madhavan P N
MP
Demeter
Lisa R
LR
Hewitt
Ross G
RG
D000328:Adult; D044966:Anti-Retroviral Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000821:virology; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy; D006679:HIV Seropositivity / Q000097:blood; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D016898:Interferon-alpha / Q000037:antagonists & inhibitors / Q000494:pharmacology; D007372:Interferons / Q000037:antagonists & inhibitors* / Q000097:blood / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012367:RNA, Viral / Q000097:blood; D012044:Regression Analysis; D014721:Vesicular stomatitis Indiana virus / Q000254:growth & development; D019562:Viral Load
D044966:Anti-Retroviral Agents; D016898:Interferon-alpha; D012367:RNA, Viral; D007372:Interferons