title: Immunosuppressive flavones and lignans from Bupleurum scorzonerifolium.
abstract: Two lignans, isochaihulactone and chaihunaphthone, together with eleven known compounds were isolated from the root of Bupleurum scorzonerifolium. Their structures were established on the basis of spectral evidence. In biological testing, eugenin and saikochromone potently inhibited CD28-costimulated activation of human peripheral blood T cells.
authors: School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan. wlchang@ndmctgh.edu.tw
authors: Wen-Liang
authors: WL
authors: Chang
authors: Li-Wen
authors: LW
authors: Chiu
authors: Jenn-Haung
authors: JH
authors: Lai
authors: Hang-Ching
authors: HC
authors: Lin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029972:Bupleurum / Q000737:chemistry*; D018106:CD28 Antigens / Q000276:immunology; D002470:Cell Survival / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D007376:Interleukin-2 / Q000037:antagonists & inhibitors / Q000378:metabolism; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D018106:CD28 Antigens; D005419:Flavonoids; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D017705:Lignans