title: Oesophagitis and bile reflux gastritis--clinical and histological assessments.
abstract: OBJECTIVE
  Little is known concerning the relationship between oesophagitis and bile reflux (chemical) gastritis despite the numerous studies on gastritis related to Helicobacter pylori. Given the importance of bile in the pathogenesis of both gastric and oesophageal disorders, we aimed at assessing the chemical gastritis score in patients with or without oesophagitis.
  
  
  METHODS
  Chemical/bile reflux gastritis score and bile reflux index were assessed in gastric biopsies taken from patients with oesophagitis and gastric surgery (group 1, n=9), gastric surgery without oesophagitis (group 2, n= 11), and oesophagitis without gastric surgery (group 3, n= 10). Endoscopic oesophageal damage was also graded on a 0-5 scale.
  
  
  RESULTS
  Group 1 had a median (interquartile range) chemical score of 6 (4-9) compared with 8 (6-10) in group 2, and 1 (0-2) in group 3 (p=0.001; Kruskal-Wallis test for multiple group comparisons). Both the reflux gastritis score and bile reflux index were lowest in patients with intact stomachs. However, the oesophageal scores were 2 (1-2) in group 1 compared with 3 (2-5) in group 3 (p=0.01).
  
  
  CONCLUSIONS
  Patients with post-surgical stomachs have similar chemical and related scores regardless of the presence or absence of oesophagitis. Despite the higher chemical gastritis scores, patients with gastric surgery, exposed mainly to bile reflux, have milder oesophagitis than those with intact stomachs, exposed to both gastric acid and bile.
authors: Crosshouse Hospital, Kilmarnock, Scotland KA2 OBE, UK. astaha@globalnet.co.uk
authors: A S
authors: AS
authors: Taha
authors: M
authors: M
authors: Balsitis
authors: W J
authors: WJ
authors: Angerson
authors: C G
authors: CG
authors: Morran
mesh_terms: D000368:Aged; D001655:Bile Reflux / Q000175:diagnosis* / Q000473:pathology; D001706:Biopsy; D016022:Case-Control Studies; D004942:Esophagitis, Peptic / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000175:diagnosis* / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D008297:Male; D013270:Stomach / Q000601:surgery