title: One thousand fifty-six hepatectomies without mortality in 8 years.
abstract: BACKGROUND
  Despite improvements in diagnostic and surgical techniques, operative mortality associated with liver resection is still greater than 2% in most of the recent studies.
  
  
  OBJECTIVE
  By refining preoperative and postoperative care and surgical skills, liver resection mortality can be decreased to zero.
  
  
  METHODS
  Retrospective cohort study to analyze postoperative morbidity and mortality in 1056 consecutive hepatectomies performed at a single medical center during 8 years.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  A total of 915 patients who underwent 1056 consecutive hepatic resections: 532 for hepatocellular carcinoma, 262 for other primary and secondary liver malignancies, 57 for biliary tract malignancy, 174 for living donor liver transplantation, and 31 for other benign diseases.
  
  
  METHODS
  Operative mortality and morbidity rates.
  
  
  RESULTS
  No operative mortality occurred. Major complications, as defined by postoperative radiologic or surgical intervention, occurred in 3% of patients with hepatocellular carcinoma, 8% with other liver malignancy, 28% with biliary malignancy, and 5% of living donor liver transplantation donors. Using multiple logistic regression, independent risk factors associated with major complications were operative blood loss of 1000 mL or greater for hepatocellular carcinoma and total bilirubin level of 1.0 mg/dL or greater (>or=17 micro mol/L) and operative time greater than 6 hours for other liver malignancy. No independent factors associated with major complications were identified for biliary malignancy or for living donor liver transplantation donors among the variables investigated in this study.
  
  
  CONCLUSIONS
  Liver resection can be performed without mortality provided that it is carried out in a high-volume medical center by well-trained hepatobiliary surgeons paying meticulous attention to the balance between the liver functional reserve and the volume of liver to be removed.
authors: Division of Hepato-Biliary-Pancreatic Surgery and Artificial Organ and Transplantation, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
authors: Hiroshi
authors: H
authors: Imamura
authors: Yasuji
authors: Y
authors: Seyama
authors: Norihiro
authors: N
authors: Kokudo
authors: Atsushi
authors: A
authors: Maema
authors: Yasuhiko
authors: Y
authors: Sugawara
authors: Keiji
authors: K
authors: Sano
authors: Tadatoshi
authors: T
authors: Takayama
authors: Masatoshi
authors: M
authors: Makuuchi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D006498:Hepatectomy / Q000379:methods / Q000401:mortality* / Q000706:statistics & numerical data; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008107:Liver Diseases / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods; D008297:Male; D019990:Perioperative Care / Q000379:methods*; D011183:Postoperative Complications / Q000453:epidemiology / Q000401:mortality*; D012189:Retrospective Studies; D016896:Treatment Outcome