Oral administration of Agaricus blazei (H1 strain) inhibited tumor growth in a sarcoma 180 inoculation model.
Agaricus blazei (H1 strain) was tested for its anticancer activity using a sarcoma 180 (S180) inoculation model and the changing patterns of splenocyte subsets were examined. Its hot-water extract was administered orally to ICR and KSN nude mice that were inoculated with S180. The growth of S180 was significantly inhibited in A.blazei treated groups. Pan T cells significantly increased in all treated groups compared to controls, even in KSN nude mice. Splenocyte subset changes were slightly different between ICR and KSN nude mice. This S180 inoculation model proved to be effective in screening the antitumor effect of basidiomycetes and allowed comparisons of immunological cellular changes between the mouse strains.
Lee
Yun-Lyul
YL
Department of Physiology, College of Medicine, Hallym University, Chunchun, Korea.
Kim
Heui-Jin
HJ
Lee
Mi-Sook
MS
Kim
Ji-Min
JM
Han
Jin-Soo
JS
Hong
Euk-Ki
EK
Kwon
Myung-Sang
MS
Lee
Min-Jae
MJ
D000284:Administration, Oral; D000364:Agaricus; D000818:Animals; D004195:Disease Models, Animal; D016131:Lymphocyte Subsets; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D013154:Spleen / Q000276:immunology; D014867:Water
D010936:Plant Extracts; D014867:Water