title: Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.
abstract: Gene expression profiling of beta-catenin, Cripto and Wnt3 mutant mouse embryos has been used to characterise the genetic networks that regulate early embryonic development. We have defined genes whose expression is regulated by beta-catenin during formation of the anteroposterior axis and the mesoderm, and have identified Cripto, which encodes a Nodal co-receptor, as a primary target of beta-catenin signals both in embryogenesis as well as in colon carcinoma cell lines and tissues. We have also defined groups of genes regulated by Wnt3/beta-catenin signalling during primitive streak and mesoderm formation. Our data assign a key role to beta-catenin upstream of two distinct gene expression programs during anteroposterior axis and mesoderm formation.
authors: Max Delbrueck Center for Molecular Medicine, Robert-Roessle-Strasse 10, 13125 Berlin, Germany.
authors: Markus
authors: M
authors: Morkel
authors: Joerg
authors: J
authors: Huelsken
authors: Maki
authors: M
authors: Wakamiya
authors: Jixiang
authors: J
authors: Ding
authors: Marc
authors: M
authors: van de Wetering
authors: Hans
authors: H
authors: Clevers
authors: Makoto M
authors: MM
authors: Taketo
authors: Richard R
authors: RR
authors: Behringer
authors: Michael M
authors: MM
authors: Shen
authors: Walter
authors: W
authors: Birchmeier
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D015820:Cadherins / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000235:genetics*; D004815:Epidermal Growth Factor; D005786:Gene Expression Regulation / Q000235:genetics*; D006133:Growth Substances / Q000235:genetics; D008562:Membrane Glycoproteins; D008648:Mesoderm / Q000502:physiology*; D051379:Mice; D016296:Mutagenesis; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D015534:Trans-Activators / Q000502:physiology*; D051153:Wnt Proteins; D060508:Wnt3 Protein; D051176:beta Catenin
chemical_list: C495267:CTNNB1 protein, mouse; D015820:Cadherins; D003598:Cytoskeletal Proteins; D006133:Growth Substances; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D011506:Proteins; C489450:Tdgf1 protein, mouse; D015534:Trans-Activators; D051153:Wnt Proteins; D060508:Wnt3 Protein; C555508:Wnt3 protein, mouse; D051176:beta Catenin; D004815:Epidermal Growth Factor