title: Absolute configuration of the thyroid hormone analog KAT-2003 as determined by the 1H NMR anisotropy method with a novel chiral auxiliary, MalphaNP acid.
abstract: The absolute configuration of the chiral thyroid hormone analog KAT-2003 (+)-2, showing hypocholesterolemic activities, decreases of hepatic triglyceride contents with lowering cardiac side effects, and significant inhibitory effect for the second primary hepatocellular carcinoma, was determined as S by the (1)H NMR anisotropy method using a novel chiral auxiliary, 2-methoxy-2-(1-naphtyl)propionic acid (MalphaNP acid).
authors: Central Research Laboratories, Kissei Pharmaceutical Co., Nagano-Pref., Japan.
authors: Toshihiro
authors: T
authors: Nishimura
authors: Hiromi
authors: H
authors: Taji
authors: Nobuyuki
authors: N
authors: Harada
mesh_terms: D000818:Animals; D016880:Anisotropy; D000924:Anticholesteremic Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011422:Propionates; D013237:Stereoisomerism; D014284:Triiodothyronine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000924:Anticholesteremic Agents; D000970:Antineoplastic Agents; D011422:Propionates; D014284:Triiodothyronine