title: A short, efficient synthesis of 2'-deoxypseudoisocytidine based on Heck-chemistry.
abstract: A novel synthesis of 2'-deoxypseudoisocytidine as well as of its phosphoramidite building block for oligonucleotide synthesis is presented. The synthesis is based on Heck-coupling between N-protected pseudoisocytosine and a silyl protected furanoid glycal. With this procedure the corresponding phosphoramidite building block is obtained in 5 steps and an overall yield of 28%.
authors: Department of Chemistry & Biochemistry, University of Bern, Bern, Switzerland.
authors: Alain
authors: A
authors: Mayer
authors: Christian J
authors: CJ
authors: Leumann
mesh_terms: D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: C487122:N-benzoyl-2'-deoxypseudoisocytidine; D003841:Deoxycytidine