Immunosuppressive flavones and lignans from Bupleurum scorzonerifolium.
Two lignans, isochaihulactone and chaihunaphthone, together with eleven known compounds were isolated from the root of Bupleurum scorzonerifolium. Their structures were established on the basis of spectral evidence. In biological testing, eugenin and saikochromone potently inhibited CD28-costimulated activation of human peripheral blood T cells.
Chang
Wen-Liang
WL
School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan. wlchang@ndmctgh.edu.tw
Chiu
Li-Wen
LW
Lai
Jenn-Haung
JH
Lin
Hang-Ching
HC
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D029972:Bupleurum / Q000737:chemistry*; D018106:CD28 Antigens / Q000276:immunology; D002470:Cell Survival / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D007376:Interleukin-2 / Q000037:antagonists & inhibitors / Q000378:metabolism; D017705:Lignans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
D000972:Antineoplastic Agents, Phytogenic; D018106:CD28 Antigens; D005419:Flavonoids; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D017705:Lignans