title: The investigation of prooxidant-antioxidant balance in serum of children with family histories of essential hypertension.
abstract: It has been accepted that essential hypertension is associated with a loss of the balance between prooxidation and antioxidation. Thus, excessive oxygen free radical production may be an early event in the pathogenesis of hypertension. To compare lipid peroxidation and antioxidant system in serum of children of essential hypertensive and normotensive parents. Serum malondialdehyde (MDA) levels were measured spectrofluorometrically. Antioxidant activity, glutathione peroxidase, selenium levels in serum were measured as indices of antioxidant power. The peroxidation of apo B containing lipoproteins (VLDL+LDL) was measured as the susceptibility to oxidation in vitro. Serum MDA levels increased, but no marked differences in total antioxidant activity, glutathione peroxidase activity, selenium levels and VLDL+LDL oxidation were found in serum of children with family histories of essential hypertension as compared to children of normotensive parents.
authors: Department of Biochemistry, Medical Faculty of Istanbul, University of Istanbul, Turkey. oztezcan@istanbul.edu.tr
authors: Serdar
authors: S
authors: Oztezcan
authors: Semra
authors: S
authors: Doğru-Abbasoğlu
authors: Umit
authors: U
authors: Mutlu-Türkoğlu
authors: Selma
authors: S
authors: Cetiner
authors: Rukiye
authors: R
authors: Eker-Omeroğlu
authors: Gülçin
authors: G
authors: Aykaç-Toker
authors: Müjdat
authors: M
authors: Uysal
mesh_terms: D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D017382:Reactive Oxygen Species / Q000097:blood*; D012643:Selenium / Q000097:blood
chemical_list: D000975:Antioxidants; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D012643:Selenium