Protective effects of ferulic acid on hyperlipidemic diabetic rats.
Diabetes, when uncontrolled, causes dyslipidemia often followed by atherogenic abnormalities. The present study was focused to determine whether ferulic acid (FA), a flavonoid, has any role to play in diabetes-induced dyslipidemia. Diabetes in rats was induced with streptozotocin. The levels of blood glucose and plasma triglycerides (TG), free fatty acids (FFA), cholesterol and phospholipids were elevated during diabetes. Treatment with FA significantly reduced the elevated plasma lipid and blood glucose levels; a more pronounced effect was found with low-dose ferulic acid than with high dose. Thus, our study demonstrates that ferulic acid lowers the lipid levels in diabetic rats and hence prevents further complications.
Sri Balasubashini
M
M
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, 608 002 Tamil Nadu, India.
Rukkumani
R
R
Menon
V P
VP
D000284:Administration, Oral; D000818:Animals; D003373:Coumaric Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005905:Glyburide / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000097:blood* / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
D003373:Coumaric Acids; D005230:Fatty Acids, Nonesterified; D007004:Hypoglycemic Agents; D014280:Triglycerides; C004999:ferulic acid; D005905:Glyburide