Cynthichlorine: a bioactive alkaloid from the tunicate Cynthia savignyi.
From ether extracts of the tunicate Cynthia savignyi, collected in Morocco, a new alkaloid-cynthichlorine-has been isolated. The structure of cynthichlorine has been characterized by extensive 2D-NMR data. Cynthichlorine possesses antifungal activity against two tomato pathogenic fungi: Botrytis cinerea and Verticillium albo atrum and antibacterial activity against Agrobacterium radiobacter, Escherichia coli and Pseudomonas aeruginosa and cytotoxicity against Artemia salina larvae.
Abourriche
A
A
Laboratoire de Chimie Organique Biomoléculaire Associé au C.N.R, Faculté des Sciences Ben M'Sik, BP 7955 Casablanca, Maroc. a.abourriche@univh2m.ac.ma
Abboud
Y
Y
Maoufoud
S
S
Mohou
H
H
Seffaj
T
T
Charrouf
M
M
Chaib
N
N
Bennamara
A
A
Bontemps
N
N
Francisco
C
C
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D017606:Chlorine Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014561:Urochordata
D000470:Alkaloids; D000890:Anti-Infective Agents; D017606:Chlorine Compounds