Microbial metabolism of the environmental estrogen bisphenol A.
Preliminary microbial metabolism studies of bisphenol A (BPA) (1) on twenty six microorganisms have shown that Aspergillus fumigatus is capable of metabolizing BPA. Scale-up fermentation of 1 with A. fumigatus gave a metabolite (2) and its structure was established as bisphenol A-O-beta-D-glucopyranoside (BPAG) based on spectroscopic analyses.
Yim
Soon-Ho
SH
College of Pharmacy, Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Korea.
Kim
Hyun Jung
HJ
Lee
Ik-Soo
IS
D000818:Animals; D001232:Aspergillus fumigatus / Q000187:drug effects / Q000378:metabolism*; D001559:Benzhydryl Compounds; D018929:Cell Culture Techniques; D004785:Environmental Pollutants / Q000009:adverse effects / Q000378:metabolism*; D004967:Estrogens / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D005960:Glucosides / Q000096:biosynthesis / Q000737:chemistry; D010636:Phenols / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D004967:Estrogens; D005960:Glucosides; D010636:Phenols; C470376:bisphenol A-O-beta-D-glucopyranoside; D000098826:Bisphenol A Compounds; C006780:bisphenol A