title: Pharmacological mechanism in slip-down behavior of mice.
abstract: Slip-down from a raised platform was previously found in mice treated with morphine, and this behavior was also recognized in mice treated with a monoamine releaser methamphetamine. Pharmacological examination on the slip-down indicated that the behavior was induced by receptor stimulations by D2 agonist PPHT and 5HT-2 agonist DOI. In mice treated with PPHT, antagonists of D1, alpha2, 5HT-2 and opioid mu and kappa suppressed the behavior. In mice treated with DOI, antagonists of D1, alpha2, 5HT-1A, 5HT-3 and opioid mu and delta suppressed the behavior. These present findings suggest that the slip-down was mainly induced by opioid mu receptor activity regulated with monoamine activities. When the slip-down is considered as an anxious behavior, it may be also suggested that the anxiety induced by 5-HT activities furthermore stimulated the behavior via the other opioid receptor activities.
authors: Psychosomatic Division, Department of Neuropsychiatry, Akita University School of Medicine, Akita 010-8543, Japan.
authors: Yutaka
authors: Y
authors: Masuda
authors: Minoru
authors: M
authors: Suzuki
authors: Takaubu
authors: T
authors: Takemura
authors: Junya
authors: J
authors: Sugawara
authors: Naxin
authors: N
authors: Guo
authors: Yang
authors: Y
authors: Liu
authors: Yoshihikio
authors: Y
authors: Kawarada
authors: Tetsuo
authors: T
authors: Shimizu
authors: Toshihiro
authors: T
authors: Sugiyama
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D018491:Dopamine Agonists / Q000494:pharmacology*; D018492:Dopamine Antagonists / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*
chemical_list: D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D008694:Methamphetamine