Alcohol ingestion influences the nocturnal cardio-respiratory activity in snoring and non-snoring males.
Night time alcohol ingestion influences nocturnal breathing in patients with sleep apnea syndrome or respiratory diseases. To evaluate the influence of nocturnal alcohol ingestion on the cardio-respiratory activity of healthy men, 8 snoring and 13 non-snoring male subjects were measured for 3 nights after alcohol ingestion. Blood alcohol concentration was 0.0, 0.5 and 0.8%, respectively. During each night polysomnographic data were obtained and analyzed. The apnea-hypopnea index was significantly higher in snoring than in non-snoring participants and increased in both groups under the influence of alcohol. Non-snoring males showed a significant increase of hypopneas under nocturnal alcohol ingestion (0.96-1.65-2.06). Mean oxygen saturation (SAO(2)) was significantly higher in non-snoring compared to snoring males, and both groups showed a significant decrease (non-snoring: 96.06%-95.7%-95.52%; snoring: 95.54%-94.74%-94.53%). Snoring individuals had a significant decrease in SAO(2) during NREM4, whereas SAO(2) was reduced significantly in REM and NREM3 in non-snoring subjects. The nocturnal heart rate was significantly increased in both groups under the influence of alcohol. The study proves that snoring and non-snoring healthy males are affected by nocturnal alcohol ingestion. Under the effect of alcohol, these patients can develop signs of a sleep apnea syndrome, which should be considered clinically.
Herzog
Michael
M
Department of Otolaryngology and Head and Neck Surgery, Universitätsklinikum Würzburg, Josef-Schneider-Str. 11, 97080 Würzburg, Germany. herzog.michael@gmx.de
Riemann
Randolf
R
D000284:Administration, Oral; D000328:Adult; D000697:Central Nervous System Stimulants / Q000008:administration & dosage* / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000187:drug effects*; D004576:Electromyography; D000431:Ethanol / Q000008:administration & dosage* / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D012119:Respiration / Q000187:drug effects*; D012913:Snoring / Q000175:diagnosis* / Q000453:epidemiology; D011795:Surveys and Questionnaires
D000697:Central Nervous System Stimulants; D000431:Ethanol