Effective diffusion volume flow rates (Qe) for urea, creatinine, and inorganic phosphorous (Qeu, Qecr, QeiP) during hemodialysis.
In vivo solute clearances can be estimated from dialyzer blood (Qb) and dialysate (Qd) flow rates and a solute- and dialyzer-specific overall permeability membrane area product (KoA). However, these calculations require knowledge of the flow rate of the effective solute distribution volume in the flowing bloodstream (Qe) in order to calculate in vivo clearances and KoAs. We have determined Qe for urea, creatinine, and inorganic phosphorus from changes in concentrations across the blood compartment and mass balance between the blood and dialysate streams. We made four serial measurements over one dialysis in 23 patients and found that Qeu equals the total blood water flow rate, Qecr equals the plasma water flow rate plus 61% of red cell water flow rate, and QeiP is limited to the plasma water flow rate. Equations are derived to calculate Qe for each of these solutes from Qb and hematocrit and in vivo KoAs for each solute were calculated.
Gotch
Frank A
FA
Renal Research Institute, New York, New York, USA. frank.gotch@fmc-na.com
Panlilio
Froilan
F
Sergeyeva
Olga
O
Rosales
Laura
L
Folden
Tom
T
Kaysen
George
G
Levin
Nathan
N
D003401:Creatine / Q000097:blood / Q000493:pharmacokinetics*; D004058:Diffusion; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy*; D010758:Phosphorus / Q000097:blood / Q000493:pharmacokinetics*; D006435:Renal Dialysis; D014508:Urea / Q000097:blood / Q000493:pharmacokinetics*
D010758:Phosphorus; D014508:Urea; D003401:Creatine