A case of non-Hodgkin's lymphoma in a patient with neurofibromatosis type 1.
Neurofibromatosis type 1 is characterized by cutaneous neurofibromas and pigmented lesions of the skin called café au lait spots. Although neurofibromatosis type 1 represents a major risk factor for the development of malignancy, especially of nervous system tumors, malignant lymphoma rarely occurs in a patients with neurofibromatosis type 1. Recently, a 77-year-old woman with neurofibromatosis type 1 was diagnosed as non-Hodgkin's Lymphoma (diffuse large B cell). She had multiple café au lait spots, neurofibromas and right axillary lymph node enlargement. An abdominal CT scan demonstrated a left pelvic mass and para-aortic lymphadenopathy. Because non-Hodgkin's Lymphoma in a neurofibromatosis patient has never been reported in Korea, herein, we describe this case and include a review of the literature.
Kim
Seok Jin
SJ
Department of Internal Medicine, Pathology, Korea University College of Medicine, Seoul, Korea.
Seo
Jae Hong
JH
Lee
Sang Woo
SW
Han
Eunmee
E
Lee
Eung Seok
ES
Cha
Sang Hoon
SH
Seo
Bo Kyoung
BK
D000368:Aged; D019080:Cafe-au-Lait Spots / Q000150:complications / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D009456:Neurofibromatosis 1 / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed