Fas-ligand mediated apoptosis in severe sepsis and shock.
Alterations in the apoptotic process in lymphoid tissues is a common condition which is encountered in the severely septic animal and critically ill patient. Here we attempt to delineate the pathological significance of these apoptotic changes and the role of Fas-FasL mediated contribution to this process.
Ayala
Alfred
A
Division of Surgical Research, Department of Surgery, Brown University School of Medicine, Rhode Island Hospital, Providence, RI 02903, USA. AAYALA@LIFESPAN.org
Lomas
Joanne L
JL
Grutkoski
Patricia S
PS
Chung
Shiang
S
D000818:Animals; D017209:Apoptosis / Q000276:immunology / Q000502:physiology*; D053222:Fas Ligand Protein; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D051379:Mice; D018805:Sepsis / Q000276:immunology / Q000473:pathology*; D012772:Shock, Septic / Q000276:immunology / Q000473:pathology*; D013950:Thymus Gland / Q000473:pathology
C505661:FASLG protein, human; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D008562:Membrane Glycoproteins