title: Treatment of anaemia in cancer patients: implications for supportive care in the National Health Service Cancer Plan.
abstract: The National Health Service (NHS) Cancer Plan published in 2000 has a short-term focus on the most pressing problems of improving survival rates and replacing equipment. It also mentioned as a target 'improved quality of life for those affected by cancer'. Continuity of care for longer-term care programmes was seen predominantly in terms of palliative care. Recent National Institute for Clinical Excellence (NICE) reports may have reinforced this approach by focussing on the clinical and cost effectiveness of chemotherapy for late-stage cancer. The impact on local decision-makers has been that drug funds have been prioritised for use on survival-enhancing interventions, with few resources left for short and longer-term supportive care targeted primarily on improving quality of life. Within supportive care, resources are particularly limited for funding treatments such as erythropoietin for the management of cancer-related anaemia, a common and very debilitating side-effect of intensive therapy. The need for a re-focusing on supportive care is associated with cancer becoming, in many instances, a longer-term illness. The prevalence of cancer is rising markedly due to increased survival rates. However, this creates a new challenge of reducing disability and improving quality of life. In surveys, patients have rated fatigue associated with anaemia as one of the most debilitating effects of their cancer and its treatment with chemotherapy. This paper reviews the evidence demonstrating the quality of life benefits of erythropoietin, and then considers the policy constraints that have limited the adoption of this treatment within the NHS. Through co-ordinated planning there are opportunities for cancer networks and primary care trusts (PCTs) working with cancer centres to develop more support in ways which are feasible and fundable. The case is argued that PCTs and cancer networks, in implementing the Cancer Plan locally, need to integrate short- and longer-term supportive care into their cancer service development plans, and recognise the importance of anaemia management as an integral part of this. Lessons can be learnt from UK renal services where anaemia management with erythropoietin is standard practice.
authors: Imperial College, University of London, UK. n.bosanquet@imperial.ac.uk
authors: Nick
authors: N
authors: Bosanquet
authors: Keith
authors: K
authors: Tolley
mesh_terms: D000740:Anemia / Q000188:drug therapy / Q000191:economics / Q000209:etiology / Q000628:therapy*; D001803:Blood Transfusion / Q000191:economics; D019058:Community Networks; D004921:Erythropoietin / Q000627:therapeutic use; D005221:Fatigue; D006801:Humans; D009369:Neoplasms / Q000150:complications*; D017410:Practice Guidelines as Topic; D011320:Primary Health Care; D011788:Quality of Life; D011994:Recombinant Proteins; D013222:State Medicine; D006113:United Kingdom
chemical_list: D011994:Recombinant Proteins; D004921:Erythropoietin