title: Cough augmentation in amyotrophic lateral sclerosis.
abstract: Cough flows and pressures were measured during cough augmentation in healthy subjects and patients with bulbar and nonbulbar amyotrophic lateral sclerosis. Manual assistance increased flow 11% in bulbar (p < 0.01) and 13% in nonbulbar (p < 0.001) patients. Mechanical insufflation-exsufflation increased flow 17% in healthy subjects (p < 0.05), 26% (p < 0.001) in bulbar, and 28% (p < 0.001) in nonbulbar patients. The greatest improvements were in patients with the weakest coughs. Patient group and level of weakness influenced the effect of augmentation.
authors: Respiratory Muscle Laboratory, Guy's, King's and St. Thomas' School of Medicine, King's College Hospital, London, UK. naveed@doctors.org.uk
authors: N
authors: N
authors: Mustfa
authors: M
authors: M
authors: Aiello
authors: R A
authors: RA
authors: Lyall
authors: D
authors: D
authors: Nikoletou
authors: D
authors: D
authors: Olivieri
authors: P N
authors: PN
authors: Leigh
authors: A C
authors: AC
authors: Davidson
authors: M I
authors: MI
authors: Polkey
authors: J
authors: J
authors: Moxham
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000503:physiopathology*; D003371:Cough / Q000503:physiopathology*; D045853:Exhalation; D005260:Female; D006801:Humans; D001239:Inhalation; D008297:Male; D010366:Peak Expiratory Flow Rate / Q000502:physiology; D012016:Reference Values; D012018:Reflex / Q000502:physiology; D012121:Respiration, Artificial / Q000295:instrumentation / Q000379:methods*; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy*; D016896:Treatment Outcome; D015919:Ventilators, Negative-Pressure