Impaired hemodynamics and neural activation? A fMRI study of major cerebral artery stenosis.
Functional MRI motor mapping was performed in two women with unilateral high-grade stenosis of the middle cerebral artery (MCA) to determine the influence of impaired hemodynamics on the blood oxygenation level dependent (BOLD) response. In both patients no structural lesions were present in primary motor pathways. A redistribution of the motor network to the healthy hemisphere was the main indicator of chronic hemodynamic compromise.
Hund-Georgiadis
M
M
Max-Planck-Institute of Cognitive Neuroscience, Leipzig, Germany. hund@cns.mpg.de
Mildner
T
T
Georgiadis
D
D
Weih
K
K
von Cramon
D Y
DY
D000328:Adult; D002908:Chronic Disease; D004525:Efferent Pathways / Q000473:pathology / Q000503:physiopathology; D005260:Female; D007839:Functional Laterality; D019786:Gadolinium DTPA; D006439:Hemodynamics; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D002546:Ischemic Attack, Transient / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology*; D012008:Recurrence; D012016:Reference Values
D019786:Gadolinium DTPA