Calcium mobilization from mitochondria in synaptic transmitter release.
Mitochondria can rapidly accumulate and release Ca2+ upon cell stimulation. A paper by Yang and coworkers in this issue reports an unusual form of synaptic potentiation, dependent on Ca2+ release from mitochondria through the Na+/Ca2+ exchanger and triggered by Na+ entry through voltage-gated channels (Yang et al., 2003).
Rizzuto
Rosario
R
Department of Experimental and Diagnostic Medicine, University of Ferrara, 44100 Ferrara, Italy. rzr@dns.unife.it
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D017729:Presynaptic Terminals / Q000378:metabolism*; D015222:Sodium Channels / Q000378:metabolism; D019831:Sodium-Calcium Exchanger / Q000378:metabolism; D009435:Synaptic Transmission / Q000502:physiology*
D018377:Neurotransmitter Agents; D015222:Sodium Channels; D019831:Sodium-Calcium Exchanger; D002118:Calcium