[Morphological changes of hepatic vessels in experimental aortal coarctation and after its elimination].
Structural peculiarities of hepatic vascular bed were studied in 10 intact dogs, 15 pups with hemodynamic model of aortal coarctation (AC) and in 10 animals after AC elimination. To detect the regularities of remodeling of arteries and veins of this organ, morphometric and histological methods were used. In the arteries, branches of portal and hepatic veins AC caused the reduction of the tone and attenuation of the media, associated with the decrease in number and dimensions of smooth muscle cells. Simultaneously, as a result of adaptation, in the intima of the vessels carrying blood to the liver (arteries) the degree of the development of regulatory muscular structures was increased, while similar structures in the blood outflow vessels (hepatic veins) were reduced. Along with adaptational modifications, some pathological changes took place in the liver, which were manifested by sclerosis of vascular walls and stroma. After AC elimination and restoration of hemodynamics, the tone of the vessels was found to increase with the hypertrophy and hyperplasia of the smooth muscles in their media. The degree of development and the number of regulatory structures in the liver inflow vascular bed were reduced, while those in the outflow bed were increased. At the same time, the process of reversal of sclerotic changes in hepatic blood vessels was initiated.
Shormanov
S V
SV
Department of Topographic Anatomy and Operative Surgery, Department of Pathologic Anatomy, Yaroslavl State Medical Academy.
Kulikov
S V
SV
D000818:Animals; D001017:Aortic Coarctation / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D004195:Disease Models, Animal; D004285:Dogs; D006499:Hepatic Artery / Q000473:pathology; D006503:Hepatic Veins / Q000473:pathology; D008099:Liver / Q000098:blood supply* / Q000503:physiopathology; D008102:Liver Circulation / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000473:pathology*