title: [Oestro-progestagen treatment combined with rivastigmine in menopausal women suffering from Alzheimer's disease. The results of a 28-weeks controlled study].
abstract: OBJECTIVE
  To compare the efficacy on cognitive function of the combination of hormone replacement therapy with rivastigmine, acetylcholinesterase inhibitor, in menopausal women suffering from mild to moderately severe Alzheimer's disease.
  
  
  METHODS
  This was a randomised double blind study of 117 women suffering from mild to moderately severe Alzheimer-like dementia (MMSE between 10 and 26). The patients were randomly assigned to continuous hormone therapy (n=59) and placebo (n=58), all receiving treatment with rivastigmine. Follow-up was of 28 weeks. ASSESSMENT CRITERIA: ADAS-Cog (Alzheimer's disease assessment scale--cognitive subscale) (primary endpoint); MMSE (mini mental state examination), GDS (global deterioration scale), CGC-Plus (clinical global change-plus), NPI (neuropsychiatric inventory), IADL (instrumental activities of daily living). Data regarding tolerance was recorded.
  
  
  RESULTS
  No significant difference was observed in the parameters assessing efficacy (cognitive function, global assessment, functioning, neuropsychiatric symptoms) and tolerance between the two groups of treatment.
  
  
  CONCLUSIONS
  Oestro-progestagen treatment did not provide further improvement when combined with rivastigmine during mild to moderately severe Alzheimer's disease.
authors: Département de gériatrie, Service du Pr F. Forette, Hôpital Broca, Paris.
authors: Anne-Sophie
authors: AS
authors: Rigaud
authors: Gabriel
authors: G
authors: André
authors: Bruno
authors: B
authors: Vellas
authors: Jacques
authors: J
authors: Touchon
authors: Jean-Jacques
authors: JJ
authors: Pere
authors: Yolande
authors: Y
authors: Loria-Kanza
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000523:psychology; D002219:Carbamates / Q000009:adverse effects / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004311:Double-Blind Method; D004967:Estrogens / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000627:therapeutic use; D009483:Neuropsychological Tests; D048448:Phenylcarbamates; D010919:Placebos; D017698:Postmenopause; D011372:Progestins / Q000009:adverse effects / Q000627:therapeutic use*; D000068836:Rivastigmine
chemical_list: D002219:Carbamates; D004967:Estrogens; D018696:Neuroprotective Agents; D048448:Phenylcarbamates; D010919:Placebos; D011372:Progestins; D000068836:Rivastigmine