title: Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat.
abstract: Ethanol extract of Cissus quadrangularis was evaluated for its anti-osteoporotic activity in ovariectomized rat model of osteoporosis at two different dose levels of 500 and 750 mg/kg per day. Healthy female albino rats were divided into five groups of six animals each. First group was sham operated and served as control. All the remaining groups were ovariectomized. Group 2 was fed with equivolume of saline and served as ovariectomized control. Groups 3-5 were orally treated with Raloxifen (5.4 mg/kg) and ethanol extract of Cissus quadrangularis (500 and 750 mg/kg), respectively. The findings assessed on the basis of biomechanical, biochemical and histopathological parameters showed that the ethanol extract of the plant had a definite antiosteoporotic effect.
authors: Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal, India. annie.shirwaikar@cops.manipal.edu
authors: Annie
authors: A
authors: Shirwaikar
authors: Saleemulla
authors: S
authors: Khan
authors: S
authors: S
authors: Malini
mesh_terms: D000818:Animals; D032422:Cissus / Q000737:chemistry*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D005260:Female; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D010052:Ovariectomy; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D018514:Plant Structures / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D023382:Toxicity Tests, Acute
chemical_list: D010936:Plant Extracts; D000431:Ethanol