[Granulometry and fractal dimensions].
The fractal character of exponential particle size distribution makes it possible to use fractal dimension for the evaluation of the results of granulometric analysis. The conditions of sedimentation analysis of talc in aqueous solution were optimized by adding nonionogenic tenside and deflocculation electrolyte. Dispersion analysis demonstrated the suitability of minimally 0.2 g/l of polysorbate 80 for talc soaking. In the evaluation of pharmaceutical granulometry, it is advisable to supplement the usually reported specific surface area with fractal dimension, which primarily contributes to a more general interpretation of variability of particle size.
Zatloukal
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Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové. zsz@faf.cuni.cz
D002626:Chemistry, Pharmaceutical; D017709:Fractals; D010316:Particle Size; D012996:Solutions; D013627:Talc
D012996:Solutions; D013627:Talc