title: Amphidinolide Y, a novel 17-membered macrolide from dinoflagellate Amphidinium sp.: plausible biogenetic precursor of amphidinolide X.
abstract: A novel cytotoxic 17-membered macrolide, amphidinolide Y (1), has been isolated from a marine dinoflagellate Amphidinium sp., and it was elucidated to exist as a 9:1 equilibrium mixture of 6-keto- and 6(9)-hemiacetal forms (1a and 1b, respectively) on the basis of 2D NMR data and chemical means. The feeding experiments with (13)C-labeled acetates suggested that amphidinolide Y (1) may be a biogenetic precursor of 16-membered macrodiolide, amphidinolide X (2).
authors: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors: Masashi
authors: M
authors: Tsuda
authors: Naoko
authors: N
authors: Izui
authors: Kazutaka
authors: K
authors: Shimbo
authors: Masaaki
authors: M
authors: Sato
authors: Eri
authors: E
authors: Fukushi
authors: Jun
authors: J
authors: Kawabata
authors: Jun'ichi
authors: J
authors: Kobayashi
mesh_terms: D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment; D000097442:Amphidinolides
chemical_list: D018942:Macrolides; C480942:amphidinolide X; D000097442:Amphidinolides; C482967:amphidinolide Y