Migraine: an ophthalmologist's perspective.
OBJECTIVE
Migraine is a common disorder with visual and neurologic manifestations. Many patients present to ophthalmologists without a previous diagnosis of migraine. It is therefore essential for the ophthalmologist to have a good understanding of migraine to appropriately help these patients. Neurologic syndromes with migraine and retinopathy are well known. Here again, the ophthalmologist may play a role in establishing the correct diagnosis.


RESULTS
For long the initial changes during a migraine attack have been shown to occur in the occipital cortex. In the recent years, the understanding of migraine has advanced with the availability of functional neuroimaging. A possible role of brainstem structures in the initiation of migraine attacks has been proposed based on functional magnetic resonance imaging blood oxygenation level-dependent signals. Activation of brainstem structures preceded activation of occipital cortex. Our understanding of cortical spreading depression is also advancing. Using multiwavelength optical intrinsic imaging, cortical spreading depression has been shown to have a triphasic response in rats. For the first time it has been shown that the cortical spreading depression activated the trigeminovascular system, which is followed by a series of cortical meningeal and brainstem events that cause the migraine headache. Sildenafil has been shown to induce migraine attack without dilation of cerebral blood vessels, further confirming that Wolf's vasogenic theory may not be true. Several loci for migraine have been identified in recent years. A new locus for migraine with and without aura has been identified on chromosome 6, a locus for migraine without aura to chromosome 14, and a locus for migraine with aura on chromosome 4.


CONCLUSIONS
Our understanding of migraine is rapidly evolving with functional neuroimaging. There are several unanswered questions. In this article, we will review the epidemiology, genetics, and clinical features of various forms of migraine with emphasis on ocular migraine, pathogenesis, and briefly the management of migraine.
Arunagiri
Guruswami
G
Neuro-Ophthalmology Service, Department of Ophthalmology, Geisinger Medical Center, Danville, Pennsylvania 17822, USA. eye@usa.com
Santhi
Shanmugam
S
D000700:Analgesics / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001905:Botulinum Toxins / Q000627:therapeutic use; D013181:Cortical Spreading Depression; D005128:Eye Diseases / Q000209:etiology*; D006801:Humans; D008881:Migraine Disorders / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology / Q000517:prevention & control
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001905:Botulinum Toxins