title: Tissue distribution of bovine viral diarrhea virus antigens in persistently infected cattle.
abstract: The tissue distribution and cellular localization of viral antigens in three cattle with persistent bovine viral diarrhea virus (BVDV) infection was studied. In three cases, necropsy findings of oral ulcers, abmasal ulcers and necrosis of Peyer's patches were suspected have been caused by BVDV infection. Non-cytopathic BVDV was isolated from a tissue pool of liver, kidneys and spleen. Immunohistochemical detection of BVDV showed that BVDV antigens were detected in both epithelial and nonepithelial cells in all examined organs, including the gastrointestinal tract, liver, pancreas, lung, lymphatic organs (spleen, lymph nodes), adrenal gland, ovary, uterus, and the mammary gland. These findings support the hypothesis that animals with persistent BVDV infection spread BVDV through all routes, and that infertility in BVDV infection is associated with the infection of BVDV in the ovaries and uteri.
authors: Department of Veterinary Medicine, Institute of Animal Science, College of Agriculture, Cheju National University, Jeju 690-756, Korea. shint@cheju.cheju.ac.kr
authors: T
authors: T
authors: Shin
authors: H
authors: H
authors: Acland
mesh_terms: D000311:Adrenal Glands / Q000473:pathology / Q000821:virology; D000818:Animals; D000956:Antigens, Viral / Q000302:isolation & purification*; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000473:pathology / Q000503:physiopathology / Q000821:virology*; D002417:Cattle; D001908:Diarrhea Viruses, Bovine Viral / Q000276:immunology / Q000302:isolation & purification*; D004064:Digestive System / Q000473:pathology / Q000821:virology; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D007247:Infertility, Female / Q000821:virology; D007668:Kidney / Q000473:pathology / Q000821:virology; D008168:Lung / Q000473:pathology / Q000821:virology; D008208:Lymphatic System / Q000473:pathology / Q000821:virology; D008321:Mammary Glands, Animal / Q000821:virology; D010053:Ovary / Q000473:pathology / Q000821:virology; D014599:Uterus / Q000473:pathology / Q000821:virology
chemical_list: D000956:Antigens, Viral