Neuropsin (Opn5): a novel opsin identified in mammalian neural tissue.
We have cloned and characterised the expression of a new opsin gene, neuropsin (Opn5), in mice and humans. Neuropsin comprises seven exons on mouse chromosome 17. Its deduced protein sequence suggests a polypeptide of 377 amino acids in mice (354 in humans), with many structural features common to all opsins, including a lysine in the seventh transmembrane domain required to form a Schiff base link with retinaldehyde. Neuropsin shares 25-30% amino acid identity with all known opsins, making it the founding member of a new opsin family. It is expressed in the eye, brain, testis and spinal cord.
Tarttelin
Emma E
EE
Department of Integrative and Molecular Neuroscience, Imperial College London, Charing Cross Hospital, St. Dunstan's Road, London W6 8RP, UK. e.tarttelin@imperial.ac.uk
Bellingham
James
J
Hankins
Mark W
MW
Foster
Russell G
RG
Lucas
Robert J
RJ
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000378:metabolism; D005091:Exons / Q000235:genetics; D005123:Eye / Q000378:metabolism; D005796:Genes; D016678:Genome; D006801:Humans; D007610:Kallikreins / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D009417:Nerve Tissue / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics; D009928:Organ Specificity; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
D009419:Nerve Tissue Proteins; C094799:KLK8 protein, human; D007610:Kallikreins