Elevated concentrations of soluble IL-2 receptor in both bronchoalveolar lavage fluid and serum in a patient with BOOP.
Activated soluble IL-2 receptor (sIL-2R) levels are elevated in a variety of diseases associated with T-cell activation. There are no reports of sIL-2R elevations in broncholitis obliterans organizing pneumonia/cryptogenic organizing pneumonia (BOOP/COP), although activated T cells are increased in BOOP/COP. We present a patient with BOOP/COP with an elevated concentration of soluble IL-2 receptors in both serum and bronchoalveolar lavage fluid. Concomitant resolution of the high serum sIL-2R and the roentogenographic findings after steroid treatment suggested that serum sIL-2R levels increase in response to a localized lymphocytic inflammatory reaction in the lung.
Matsuno
Osamu
O
Department of Internal Medicine, Usuki Cosmos Hospital, Usuki, Oita 875-0051, Japan. matsuno@oita-med.ac.jp
Okubo
Fumiko
F
Masutomo
Kazuhiro
K
Yoshida
Fumio
F
Okubo
Tosiyuki
T
Miyazaki
Eishi
E
Kumamoto
Tosihide
T
D001706:Biopsy; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D018549:Cryptogenic Organizing Pneumonia / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D013902:Radiography, Thoracic; D015375:Receptors, Interleukin-2 / Q000032:analysis / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
D005938:Glucocorticoids; D015375:Receptors, Interleukin-2; D011239:Prednisolone