T-cell immunotherapy of allergic disease: the role of CD8+ T cells.
OBJECTIVE
The scope of this review is to place recent advances in T-cell immunotherapy into an account of our understanding of the potential role of CD8+ T cells in the pathogenesis of allergic disease.


RESULTS
Studies over the last year suggest that changes in CD8+ T-cell function may represent key events in successful T-cell immunotherapy. The first human human leukocyte antigen class I allergen epitopes have now been described and will provide further insights into the role of allergen-specific CD8+ T cells.


CONCLUSIONS
The coupling of recent technical advances in the study of antigen-specific T cells with the knowledge of human allergen class I epitopes will promote rapid progress in the field, with potential consequences for the diagnosis, monitoring and immunotherapeutic treatment of affected individuals.
Ogg
Graham S
GS
Weatherall Institute of Molecular Medicine, Oxford, UK. gogg@molbiol.ox.ac.uk
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000502:physiology*; D015234:HLA-A Antigens / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000628:therapy*; D007167:Immunotherapy
D015234:HLA-A Antigens