Detection of anti-MHAV and anti-MHEV IgM in patients with sporadic acute hepatitis in Beijing between 1995-2000.
OBJECTIVE
To investigate the age range, liver function damage and prognosis of patients with sporadic acute hepatitis A and E in Beijing.


METHODS
Enzyme immunoassay (EIA) was used to detect anti-HAV and anti-HEV immunoglobulin M (IgM). Serum samples were collected from the patients with sporadic acute viral hepatitis in Beijing from January 1995 to June 2000.


RESULTS
The total Positive rate for anti-HAV and anti-HEV IgM was 55.2% (112) in 203 patients with acute hepatitis, of whom 22.2% (45 patients) and 33.0% (67) were positive for anti-HAV and anti-HEV respectively. The duration of anti-HEV IgM was 45-60 days and that of anti-HAV IgM was at least 2-3 months. The patients with acute hepatitis A and hepatitis E all experienced jaundice and a rising of liver enzyme, but did not develop chronic hepatitis or died.


CONCLUSIONS
Acute hepatitis A as well as acute hepatitis E plays an important role in sporadic enterically transmitted hepatitis in Beijing.
Lu
Jian
J
Laboratory of Hepatitis, Institute of Virology, Chinese Academy of Preventive Medicine, Beijing 100052, China. jlu@btamial.net.cn
Zhao
Hong-Lan
HL
Meng
Qing-Ling
QL
Liao
Sheng-Dong
SD
Wang
Yuan
Y
Jiang
Yong-Zhen
YZ
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000410:Alanine Transaminase / Q000097:blood; D000918:Antibody Specificity; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D006506:Hepatitis A / Q000453:epidemiology* / Q000276:immunology*; D035922:Hepatitis A Antibodies / Q000097:blood; D016751:Hepatitis E / Q000453:epidemiology* / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D014505:Urban Population
D035922:Hepatitis A Antibodies; D007075:Immunoglobulin M; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin