title: Association between altered circadian blood pressure profile and cardiac end-organ damage in patients with renovascular hypertension.
abstract: BACKGROUND
  Patients with renovascular hypertension (RVH) have a higher degree of cardiovascular end-organ damage compared to patients with essential hypertension (EH). The precise mechanisms underlying this phenomenon, however, have not been fully elucidated. This study investigated the relationship between circadian blood pressure (BP) profile and cardiac involvement in patients with RVH and EH.
  
  
  METHODS
  Twenty patients with RVH and 20 with EH, matched for demographic characteristics, underwent simultaneous 24-hour ambulatory BP recording and Holter ECG monitoring. Also, each participant underwent echocardiographic assessment of left ventricular mass. Cardiac damage was defined as the presence of left ventricular hypertrophy, myocardial ischemia or arrhythmias.
  
  
  RESULTS
  Casual BP was similar in both groups, whereas 24-hour ambulatory BP values were higher in RVH than in EH patients; moreover, RVH patients had higher blood pressure variability and blunted nocturnal BP fall compared to those with EH. Left ventricular mass, as well as the prevalence of myocardial ischemia and the presence and severity of cardiac arrhythmias, were higher in RVH than in EH patients.
  
  
  CONCLUSIONS
  Patients with RVH have altered circadian BP profile compared to those with EH. This abnormality might contribute to their increased prevalence of cardiac damage and might adversely affect the prognosis of these patients.
authors: Istituto di Patologia Speciale Medica e Semeiotica Medica, Università Cattolica del Sacro Cuore, Rome, Italy.
authors: Micaela
authors: M
authors: Iantorno
authors: Roberto
authors: R
authors: Pola
authors: Francesca
authors: F
authors: Schinzari
authors: Gianluca
authors: G
authors: Filice
authors: Marco
authors: M
authors: Mettimano
authors: Carmine
authors: C
authors: Cardillo
authors: Domenico
authors: D
authors: Melina
mesh_terms: D018660:Blood Pressure Monitoring, Ambulatory; D002940:Circadian Rhythm; D015150:Echocardiography, Doppler; D015716:Electrocardiography, Ambulatory; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis; D006978:Hypertension, Renovascular / Q000175:diagnosis* / Q000453:epidemiology; D017379:Hypertrophy, Left Ventricular / Q000453:epidemiology / Q000209:etiology*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011336:Probability; D011446:Prospective Studies; D018570:Risk Assessment; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index