[Long-term outcome of advanced hepatocellular carcinoma that received transarterial hepatic chemotherapy].
Nineteen patients with far advanced hepatocellular carcinoma received transarterial hepatic chemotherapy. Twelve patients were Child-Pugh A, 2 were B, and 2 were C. Seventeen patients had portal vein thrombus, and 2 patients had extra-hepatic metastasis. Among the 19 patients, 13 received low-dose CDDP and 5-FU, and 5-FU with interferon was performed in 2. Lipiodol chemotherapy with epirubicin and MMC was performed after first-line chemotherapy, following the evaluation of the progressive disease. The 1- and 3-year survival rates in all cases were 42.5% and 18.2%, respectively. Of the 18 patients evaluated for response, 1 showed complete response, 2 showed partial responses, 8 had stable disease, and 7 progressed. Median survival time of CR, PR and SD patients was 14.2 months. A multivariate analysis identified CLIP score and therapeutic effect as independent predictors for mortality. It is concluded that transarterial hepatic chemotherapy was very useful for far advanced hepatocellular carcinoma.
Masutani
Seizo
S
Dept. of Surgery, Sakai City Hospital.
Shimizu
Junzo
J
Tatsuta
Masayuki
M
Masuda
Fumikazu
F
Imamura
Hiroshi
H
Ishida
Hideyuki
H
Furukawa
Hiroshi
H
Tomotsu
Kouichi
K
Yura
Mamoru
M
Obana
Takashi
T
Kitamura
Shinji
S
Saeki
Naoya
N
Inoue
Yutaka
Y
Takamura
Manabu
M
Ohnishi
Hiromitsu
H
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D011379:Prognosis; D015996:Survival Rate; D013927:Thrombosis / Q000209:etiology; D016896:Treatment Outcome
D002945:Cisplatin; D005472:Fluorouracil