Genetic screening of karyotypes and azoospermic factors for infertile men who are candidates for ICSI.
The overall incidence of chromosomal abnormalities was 8%. There was no single distinctive feature of semen parameters predictive of the existence of a chromosomal anomaly. All of the patients with obstructive azoospermia had normal karyotypes and AZF. Three patients out of 13 (23%) with nonobstructive azoospermia without 47,XXY had AZF deletions, as well as two (5%) of 43 with severe oligozoospermia. Ninety-two couples underwent 112 ICSI cycles for which a pregnancy rate of 58% was achieved. Five patients with abnormal karyotypes underwent 6 cycles of ICSI that resulted in 1 successful pregnancy. Two patients with AZF deletions achieved pregnancies. One ICSI-derived male had the same AZF deletion as his father, and 1 female baby had no risk of AZF deletion. The authors recommend karyotyping, excluding those with obstructive causes, prior to ICSI for genetic counseling.
Chen
S-U
SU
Department of Obstetrics and Gynecology, National Taiwan University Hospital, No. 7 Chung-Shan South Road, Taipei, Taiwan.
Lien
Y-R
YR
Ko
T-M
TM
Ho
H-N
HN
Yang
Y-S
YS
Chang
H-C
HC
D000328:Adult; D002869:Chromosome Aberrations; D041322:Chromosomes, Human, Y / Q000235:genetics; D005260:Female; D005820:Genetic Testing; D006801:Humans; D007248:Infertility, Male / Q000453:epidemiology / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D009845:Oligospermia / Q000235:genetics*; D011247:Pregnancy; D018873:Pregnancy Rate; D020554:Sperm Injections, Intracytoplasmic; D013624:Taiwan / Q000453:epidemiology