Effects of ursodeoxycholic acid on photodynamic therapy in a murine tumor model.
We previously reported that the efficacy of photodynamic therapy (PDT) in cell culture was enhanced by ursodeoxycholic acid (UDCA), a nontoxic bile acid. In this study, we examined the ability of UDCA to promote tumor control by PDT in the mouse, using the radiation-induced fibrosarcoma tumor and the photosensitizing agent tin etiopurpurin (SnET2). These experiments revealed that the addition of UDCA to a PDT protocol promoted inhibition of tumor growth, a phenomenon unrelated to either altered SnET2 biodistribution or the level of vascular shutdown during irradiation. These results indicate that UDCA acts solely by promoting direct tumor cell kill by PDT.
Garbo
Greta M
GM
Department of Surgery, University of Louisville, Louisville, KY, USA.
Vicente
M Graça
MG
Fingar
Victor
V
Kessel
David
D
D000818:Animals; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008954:Models, Biological; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011166:Porphyrins / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014018:Tissue Distribution; D014580:Ursodeoxycholic Acid / Q000494:pharmacology* / Q000627:therapeutic use
D017319:Photosensitizing Agents; D011166:Porphyrins; C063166:tin etiopurpurin; D014580:Ursodeoxycholic Acid