Cysteinyl-leukotrienes and the liver.
Leukotrienes are potent biological mediators implicated in an increasing number of disease processes. This review outlines the basic biology of leukotrienes and discusses recent developments in our understanding of the specific role of cysteinyl-leukotrienes (cLTs) in cholestasis, hepatic inflammation, portal hypertension, and the pathogenesis of the hepatorenal syndrome (HRS).
Farzaneh-Far
Ramin
R
Department of Medicine, Centre for Hepatology, Royal Free & University College Medical School, Rowland Hill St., London NW3 2PF, UK.
Moore
Kevin
K
D000818:Animals; D002779:Cholestasis / Q000378:metabolism; D003545:Cysteine / Q000378:metabolism*; D006530:Hepatorenal Syndrome / Q000378:metabolism; D006801:Humans; D015289:Leukotrienes / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction
D015289:Leukotrienes; C112381:cysteinyl-leukotriene; D003545:Cysteine