High efficiency and enantioselectivity in the rh-catalyzed conjugate addition of arylboronic acids using monodentate phosphoramidites.
A very fast reaction and enantioselectivities >98% have been reached in the rhodium-catalyzed arylboronic acid addition to enones using a monodentate phosphoramidite ligand. Temperature-dependent studies show that monodentate phosphoramidites form stable complexes with metals and can induce high enantioselectivities even at high temperatures in polar solvents.
Boiteau
Jean-Guy
JG
Department of Organic and Molecular Inorganic Chemistry, Stratingh Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Minnaard
Adriaan J
AJ
Feringa
Ben L
BL