Dissociable correlates of recollection and familiarity within the medial temporal lobes.
Regions in the medial temporal lobes (MTL) have long been implicated in the formation of new memories for events, however, it is unclear whether different MTL subregions support different memory processes. Here, we used event-related functional magnetic resonance imaging (fMRI) to examine the degree to which two recognition memory processes-recollection and familiarity-were supported by different MTL subregions. Results showed that encoding activity in the rhinal cortex selectively predicted familiarity-based recognition, whereas, activity in the hippocampus and posterior parahippocampal cortex selectively predicted recollection. Collectively, these results support the view that different subregions within the MTL memory system implement unique encoding processes that differentially support familiarity and recollection.
Ranganath
Charan
C
Center for Neuroscience and Department of Psychology, University of California at Davis, 1544 Newton Ct., Davis, CA 95616, USA. cranganath@ucdavis.edu
Yonelinas
Andrew P
AP
Cohen
Michael X
MX
Dy
Christine J
CJ
Tom
Sabrina M
SM
D'Esposito
Mark
M
D000293:Adolescent; D000328:Adult; D003071:Cognition / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D017397:Prefrontal Cortex / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D013702:Temporal Lobe / Q000502:physiology*
D010100:Oxygen