title: [Successful treatment of postoperative multiple hepatic recurrence with hepatic arterial infusion of cisplatin and degrable starch microspheres].
abstract: A 38-year-old man had multiple recurrence of hepatocellular carcinoma (HCC) with portal vein thrombosis after hepatectomy and postoperative transcatheter arterial chemotherapy with 5-fluorouracil (5-FU). He was treated by trans hepatic arterial embolization (TAE) with 100 mg of cisplatin (CDDP) and degrable starch microspheres (DSM). After 3 courses were administered, the recurrent lesions almost disappeared on CT, and the postoperative rise in PIVKA-II level and AFP level normalized. There were no side effects except slight fever and general fatigue. We recognized a partial response, and the patient is still alive 14 months after hepatectomy. This case suggests that TAE with CDDP and DSM might be useful for prolonging the survival of advanced HCC patients.
authors: Dept. of Surgery, NTT West Osaka Hospital.
authors: Masahiro
authors: M
authors: Murakami
authors: Takeshi
authors: T
authors: Tono
authors: Mitsunobu
authors: M
authors: Imazato
authors: Hirotoshi
authors: H
authors: Takemoto
authors: Tadashi
authors: T
authors: Asaoka
authors: Kazuyuki
authors: K
authors: Okada
authors: Toshiyuki
authors: T
authors: Kanoh
authors: Takashi
authors: T
authors: Iwazawa
authors: Tadashi
authors: T
authors: Ohnishi
authors: Yoshiaki
authors: Y
authors: Nakano
authors: Hiroshi
authors: H
authors: Yano
authors: Masakatsu
authors: M
authors: Kinuta
authors: Jyun
authors: J
authors: Okamura
authors: Takushi
authors: T
authors: Monden
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D015415:Biomarkers; D014408:Biomarkers, Tumor / Q000097:blood; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D002945:Cisplatin / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D006498:Hepatectomy; D006499:Hepatic Artery; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000097:blood / Q000628:therapy*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D011169:Portal Vein; D011498:Protein Precursors / Q000097:blood; D011516:Prothrombin; D013213:Starch / Q000008:administration & dosage*; D013927:Thrombosis / Q000209:etiology
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D014408:Biomarkers, Tumor; D011498:Protein Precursors; C083286:degradable starch microspheres; C008208:acarboxyprothrombin; D011516:Prothrombin; D013213:Starch; D002945:Cisplatin