Restenosis following balloon dilation of benign esophageal stenosis.
OBJECTIVE
To elucidate the mechanism of restenosis following balloon dilation of benign esophageal stenosis.


METHODS
A total of 49 rats with esophageal stenosis were induced in 70 rats using 5 ml of 50% sodium hydroxide solution and the double-balloon method, and an esophageal restenosis (RS) model was developed by esophageal stenosis using dilation of a percutaneous transluminal coronary angioplasty (PTCA) balloon catheter. These 49 rats were divided into two groups: rats with benign esophageal stricture caused by chemical burn only (control group, n=21) and rats with their esophageal stricture treated with balloon catheter dilation (experimental group, n=28). Imaging analysis and immunohistochemistry were used for both quantitative and qualitative analyses of esophageal stenosis and RS formation in the rats, respectively.


RESULTS
Cross-sectional areas and perimeters of the esophageal mucosa layer, muscle layer, and the entire esophageal layers increased significantly in the experimental group compared with the control group. Proliferating cell nuclear antigen (PCNA) was expressed on the 5th day after dilation, and was still present at 1 month. Fibronectin (FN) was expressed on the 1st day after dilation, and was still present at 1 month.


CONCLUSIONS
Expression of PCNA and FN plays an important role in RS after balloon dilation of benign esophageal stenosis.
Cheng
Ying-Sheng
YS
Department of Radiology, Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China. chengys@sh163.net
Li
Ming-Hua
MH
Yang
Ren-Jie
RJ
Zhang
Hui-Zhen
HZ
Ding
Zai-Xian
ZX
Zhuang
Qi-Xin
QX
Jiang
Zhi-Ming
ZM
Shang
Ke-Zhong
KZ
D000818:Animals; D002404:Catheterization; D004940:Esophageal Stenosis / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D004947:Esophagus / Q000378:metabolism / Q000473:pathology; D005353:Fibronectins / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology; D009130:Muscle, Smooth / Q000378:metabolism / Q000473:pathology; D011183:Postoperative Complications / Q000378:metabolism / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012008:Recurrence
D005353:Fibronectins; D018809:Proliferating Cell Nuclear Antigen