Morning pseudoneutropenia during clozapine treatment.
Clozapine, an atypical antipsychotic drug, is associated with a high risk of neutropenia and agranulocytosis, necessitating the immediate discontinuation of the drug. We report the case of a patient who developed clozapine-induced neutropenia. Assessments revealed a pronounced diurnal variation in the number of circulating neutrophils (1200-1900/mm(3) in the morning and 2200-2700/mm(3) in the afternoon). Due to these circadian changes, we decided to continue clozapine treatment.
Esposito
David
D
Service de Psychiatrie du Professeur Rouillon, Hôpital Albert Chenevier, Créteil, France.
Aouillé
Jérémie
J
Rouillon
Frédéric
F
Limosin
Frédéric
F
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002940:Circadian Rhythm; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000139:chemically induced* / Q000175:diagnosis; D012563:Schizophrenia, Paranoid / Q000097:blood / Q000188:drug therapy*
D014150:Antipsychotic Agents; D003024:Clozapine