Synthesis and antibacterial activity of pyrroloaryl-substituted oxazolidinones.
A novel series of oxazolidinones containing a pyrroloaryl substituent was synthesized and screened against a representative panel of susceptible and resistant Gram-positive bacteria. Several members of this series were found to have antibacterial activity comparable to or better than linezolid.
Paget
Steven D
SD
Johnson & Johnson Pharmaceutical Research & Development, L.L.C., Route 202, PO Box 300, Raritan, NJ 08869, USA. spaget@prdus.jnj.com
Foleno
Barbara D
BD
Boggs
Christine M
CM
Goldschmidt
Raul M
RM
Hlasta
Dennis J
DJ
Weidner-Wells
Michele A
MA
Werblood
Harvey M
HM
Wira
Ellyn
E
Bush
Karen
K
Macielag
Mark J
MJ
D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid