Two year prognosis of sarcoidosis: the ACCESS experience.
A cohort of 215 sarcoidosis patients from the ACCESS study underwent a clinical evaluation at study enrollment and two years later. Approximately 80% of subjects had an improved or stable FVC, FEV1, chest radiograph determined by Scadding stage, and dyspnea scale. African-Americans had less improvement in FVC than Caucasians (p = 0.04). Patients with erythema nodosum at presentation were more likely to have improvement in the chest radiograph at two-year follow-up (p = 0.007). Patients with a lower annual family income were more likely to worsen with respect to dyspnea (p = 0.01) and more likely to have new organ involvement at two-year follow-up (p = 0.045). The development of new organ involvement over the two year follow-up period was more common in African-Americans compared to Caucasians (p = 0.002) and more likely in those with extrapulmonary involvement at study entry (p = 0.003). There was an excellent concordance between changes in FVC and FEV1 over the two-year period. However, changes in FVC alone were inadequate to describe the change in pulmonary status of the patients, as changes in chest radiographic findings or the level of dyspnea did often but not always move in the same direction as FVC. In conclusion, data from this heterogeneous United States sarcoidosis population indicate that sarcoidosis tends to improve or remain stable over two years in the majority of patients. Several factors associated with improved or worse outcome over two years were identified.
Judson
Marc A
MA
Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, Charleston, SC 29425, USA. judsonma@MUSC.edu
Baughman
Robert P
RP
Thompson
Bruce W
BW
Teirstein
Alvin S
AS
Terrin
Michael L
ML
Rossman
Milton D
MD
Yeager
Henry
H
McLennan
Geoffrey
G
Bresnitz
Eddy A
EA
DePalo
Louis
L
Hunninghake
Gary
G
Iannuzzi
Michael C
MC
Johns
Carol J
CJ
Moller
David R
DR
Newman
Lee S
LS
Rabin
David L
DL
Rose
Cecile
C
Rybicki
Benjamin A
BA
Weinberger
Steven E
SE
Knatterud
Genell L
GL
Cherniak
Reuben
R
D000328:Adult; D001741:Black or African American; D016022:Case-Control Studies; D015331:Cohort Studies; D018450:Disease Progression; D004417:Dyspnea / Q000145:classification / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012129:Respiratory Function Tests; D012507:Sarcoidosis / Q000150:complications* / Q000473:pathology*; D014481:United States; D044465:White People