HAART induces the expression of HLA-G on peripheral monocytes in HIV-1 infected individuals.
The aim of this work is to analyze if the highly active antiretroviral therapy (HAART) has any effect in the number of peripheral monocytes expressing the tolerogenic molecule human leukocyte antigen G (HLA-G) in HIV-1 infected individuals. In this sense, expression of HLA-G was measured by flow cytometry on peripheral monocytes from HIV-1 antiretroviral-receiving and antiretroviral naïve patients and in HIV-1 patients at different times after the antiretroviral treatments were removed. It was found an increment of monocytes expressing HLA-G in HIV-1 infected individuals receiving HAART, whereas monocytes from untreated HIV-1 patients did not change. When the HLA-G was measured on monocytes after antiretroviral treatment was removed, the number of peripheral monocytes expressing HLA-G was progressively decreasing. These data suggest that antiretroviral therapy is able to induce the expression of the tolerogenic molecule HLA-G on peripheral monocytes from HIV-1 seropositive individuals.
Cabello
Almudena
A
Service of Immunology, Reina Sofía University Hospital, University of Cordoba, Spain.
Rivero
Antonio
A
Garcia
Mariá José
MJ
Lozano
José Manuel
JM
Torre-Cisneros
Julian
J
González
Rafael
R
Dueñas
Gema
G
Galiani
Maria Dolores
MD
Camacho
Angela
A
Santamaria
Manuel
M
Solana
Rafael
R
Montero
Carmen
C
Kindelán
José Mariá
JM
Peña
José
J
D023241:Antiretroviral Therapy, Highly Active; D005434:Flow Cytometry; D015658:HIV Infections / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D015497:HIV-1; D006680:HLA Antigens / Q000096:biosynthesis / Q000097:blood* / Q000235:genetics; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis / Q000097:blood* / Q000235:genetics; D006801:Humans; D009000:Monocytes / Q000276:immunology*; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use
D017320:HIV Protease Inhibitors; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D018894:Reverse Transcriptase Inhibitors