title: Preliminary evaluation of antinephritis and radical scavenging activities of glabridin from Glycyrrhiza glabra.
abstract: Antinephritis activity of glabridin, a pyranoisoflavan isolated from Glycyrrhiza glabra, was evaluated after its oral administration to mice with glomerular disease (Masugi-nephritis) by measuring the urinary protein excretion, total cholesterol, serum creatinine and blood urea nitrogen levels. Administration of glabridin for 10 days (30 mg kg(-1) day(-1)) reduced the amount of urinary protein excretion from control level (100+/-23 mg/day) to a significantly lower level (47+/-4 mg/day). ESR spectroscopy demonstrated that glabridin neither produced radical, nor affected the radical intensity of sodium ascorbate, suggesting the lack of correlation between the antinephritis activity and radical scavenging activity.
authors: Department of Physico-Chemical Analysis, School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan. fukai@phar.toho-u.ac.jp
authors: Toshio
authors: T
authors: Fukai
authors: Kazue
authors: K
authors: Satoh
authors: Taro
authors: T
authors: Nomura
authors: Hiroshi
authors: H
authors: Sakagami
mesh_terms: D000818:Animals; D001806:Blood Urea Nitrogen; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006035:Glycyrrhiza; D007529:Isoflavones; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009393:Nephritis / Q000188:drug therapy; D010636:Phenols / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D016166:Free Radical Scavengers; D007529:Isoflavones; D010636:Phenols; D010936:Plant Extracts; D002784:Cholesterol; D003404:Creatinine; C107601:glabridin