title: Stripping voltammetric and polarographic techniques for the determination of anti-fungal ketoconazole on the mercury electrode.
abstract: The electroanalytical behaviour of ketoconazole in Britton-Robinson buffer is described. The reduction process on the hanging mercury drop electrode (HMDE) gives rise to one peak over -1.6 V (vs. Ag/AgCl/sat.KCl), within the pH range studied (4.7-9.6). The results showed that the reduction of ketoconazole is irreversible and the limiting current is adsorption controlled. The dependence of the peak current on the concentration was studied by means of different polarographic and voltammetric techniques. Using adsorptive stripping differential pulse voltammetry (AdS-DPV), the detection limit (DL) reached was 5.3 x 10(-11) mol l(-1). Two procedures, based on differential pulse polarography (DPP) and AdS-DPV in aqueous medium were developed for the determination of ketoconazole in a gel formulation and spiked urine samples, respectively.
authors: Departamento de Qui;mica Anali;tica, Facultad de Farmacia, Universidad del País Vasco/EHU, Apartado 450, D.P. 01080, Vitoria, Spain.
authors: Pablo
authors: P
authors: Arranz
authors: Adela
authors: A
authors: Arranz
authors: José María
authors: JM
authors: Moreda
authors: Adolfo
authors: A
authors: Cid
authors: Juan Francisco
authors: JF
authors: Arranz
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000652:urine*; D004563:Electrochemistry; D004566:Electrodes; D007654:Ketoconazole / Q000737:chemistry / Q000652:urine*; D008628:Mercury / Q000032:analysis*
chemical_list: D000935:Antifungal Agents; D008628:Mercury; D007654:Ketoconazole