title: Treadmill exercise decreases intrastriatal hemorrhage-induced neuronal cell death via suppression on caspase-3 expression in rats.
abstract: Intracerebral hemorrhage is one of the most devastating types of stroke. This disease is known to cause severe neurological damage and also has a very high mortality rate. In this study, the effect of treadmill exercise on intrastriatal hemorrhage-induced neuronal cell death was investigated. Intrastriatal hemorrhage was caused by injection of collagenase into the striatum using a stereotaxic instrument. Animals of the exercise group were made to run on a treadmill for 30 min once a day during 10 consecutive days. In the present results, treadmill exercise was shown to suppress the increase in the size of hemorrhage-induced lesions and the increase in caspase-3 expression in the striatum. Based on these results, it is possible that treadmill exercise aids in the recovery from central nervous system sequelae following intracerebral hemorrhage.
authors: Department of Physiology, College of Medicine, Kyung Hee University, # 1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea.
authors: Hee-Hyuk
authors: HH
authors: Lee
authors: Hong
authors: H
authors: Kim
authors: Myoung-Hwa
authors: MH
authors: Lee
authors: Hyun-Kyung
authors: HK
authors: Chang
authors: Taeck-Hyun
authors: TH
authors: Lee
authors: Mi-Hyeon
authors: MH
authors: Jang
authors: Min-Chul
authors: MC
authors: Shin
authors: Baek-Vin
authors: BV
authors: Lim
authors: Mal-Soon
authors: MS
authors: Shin
authors: Young-Pyo
authors: YP
authors: Kim
authors: Jin-Hwan
authors: JH
authors: Yoon
authors: Il-Gyu
authors: IG
authors: Jeong
authors: Chang-Ju
authors: CJ
authors: Kim
mesh_terms: D000818:Animals; D053148:Caspase 3; D061945:Caspase Inhibitors; D020169:Caspases / Q000096:biosynthesis* / Q000502:physiology; D016923:Cell Death / Q000502:physiology; D002543:Cerebral Hemorrhage / Q000201:enzymology* / Q000473:pathology / Q000517:prevention & control; D003342:Corpus Striatum / Q000201:enzymology* / Q000473:pathology; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology; D008297:Male; D009474:Neurons / Q000201:enzymology* / Q000473:pathology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D061945:Caspase Inhibitors; C505410:Casp3 protein, rat; D053148:Caspase 3; D020169:Caspases