title: Plasma cytokine levels in patients with obstructive sleep apnea syndrome: a preliminary study.
abstract: The levels of some pro- and anti-inflammatory cytokines [interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha, IL-6, IL-10, and transforming growth factor (TGF)-beta], were measured by enzyme-linked immunosorbent assay (ELISA) method in the plasma of patients affected by obstructive sleep apnea syndrome (OSAS) at 22:00 hours before polysomnographic recording and immediately after the first obstructive apnea causing an SaO2 below 85%. Significantly higher levels of TNF-alpha were found in OSAS patients assessed before polysomnography compared with the control group (P < 0.01). A slight but significant increase in the plasma levels of IL-6 was also present (P < 0.05). Conversely, a significant decrease in the plasma levels of IL-10 was evident at baseline in OSAS patients (P < 0.04). No significant difference emerged between the mean values of IL-1alpha and TGF-beta between OSAS patients and controls. The present data support a prevailing activation of the Th1-type cytokine pattern in OSAS patients, which is not associated with the severity and duration of OSAS. This can have important consequences for the outcome of OSAS patients, especially with regard to the increased risk for developing atherosclerosis and cardiovascular and cerebrovascular diseases. Immediately after the first obstructive apnea causing an SaO2 <85%, a significant variation was observed in the plasma levels of TNF-alpha in OSAS patients compared with those measured before the beginning of polysomnographic recording (P < 0.001). The role played by this further increase in TNF-alpha levels after the obstructive apnea in OSAS patients remains to be established in the light of the pathogenic mechanisms of this sleep disorder.
authors: Department of Neuroscience, Neurologic Clinic Department of Internal Medicine, University of Perugia, Perugia, Italy. andrea_alberti@hotmail.com
authors: Andrea
authors: A
authors: Alberti
authors: Paola
authors: P
authors: Sarchielli
authors: Elisabetta
authors: E
authors: Gallinella
authors: Ardesio
authors: A
authors: Floridi
authors: Alessandro
authors: A
authors: Floridi
authors: Giovanni
authors: G
authors: Mazzotta
authors: Virgilio
authors: V
authors: Gallai
mesh_terms: D000704:Analysis of Variance; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood* / Q000276:immunology*; D016753:Interleukin-10 / Q000097:blood* / Q000276:immunology*; D015850:Interleukin-6 / Q000097:blood* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000175:diagnosis / Q000276:immunology*; D016212:Transforming Growth Factor beta / Q000097:blood* / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology* / Q000378:metabolism*
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10