Impact of margarine enriched with plant sterols on blood lipids, platelet function, and fibrinogen level in young men.
The effects of margarines enriched with omega-6 polyunsaturated fatty acids (PUFA), as well as those containing plant sterols or stanols, on reduction of plasma low-density lipoprotein-cholesterol (LDL-C) have been extensively studied. However, their impact on fibrinogen (Fb) concentration and blood platelet function is much less known. Our research involved 42 healthy male students (average age, 23.7 +/- 1.6) who during the research period were subjected to a controlled regime of nutrition and physical activity. After a period of diet stabilization involving 30 g butter daily in 2 servings, the subjects were randomly divided into 2 groups. In the first group, the butter was replaced by the same quantity of PUFA margarine, while the second group received margarine with added plant sterols instead of butter. The subjects consuming margarine with sterols showed a significant (11%) decrease in LDL-C (P<.001). Margarine rich in PUFA caused a 6% reduction in LDL-C (P<.01), with a simultaneous 3% reduction in high-density lipoprotein-cholesterol (HDL-C) (P<.001). Both types of margarine increased the concentration of Fb (P<.001), without exceeding the normal medium value of 2.8 g/L. After the consumption of margarine with sterols, the adhesion and aggregation time of blood platelets was significantly prolonged after collagen-epinephrine activation. Margarine with sterols, through its antiplatelet activity and the significant reduction of LDL-C, can play a vital role in the nonpharmacologic prevention of circulatory diseases.
Kozłowska-Wojciechowska
Małgorzata
M
Department of Nutrition Education, National Institute of Food and Nutrition, Warsaw, Poland.
Jastrzebska
Maria
M
Naruszewicz
Marek
M
Foltyńska
Anna
A
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D004032:Diet; D043371:Fatty Acids, Omega-6 / Q000494:pharmacology; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008383:Margarine; D010840:Phytosterols / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010979:Platelet Function Tests; D014280:Triglycerides / Q000097:blood
D043371:Fatty Acids, Omega-6; D008055:Lipids; D010840:Phytosterols; D014280:Triglycerides; D008383:Margarine; D005340:Fibrinogen; D002784:Cholesterol