Antimalarial activity of Sida acuta Burm. f. (Malvaceae) and Pterocarpus erinaceus Poir. (Fabaceae).
Among strategies to combat malaria, the search for new antimalarial drugs appears to be a priority. Sheering for new antimalarial activities, four plants of the traditional medicine of Burkina Faso: Combretum micranthum, Khaya senegalensis, Pterocarpus erinaceus and Sida acuta, were tested in vitro on fresh clinical isolates of Plasmodium falciparum. The screening showed that Sida acuta has a significant activity (IC50 < 5 microg/ml), and Pterocarpus erinaceus has a moderate activity (5 microg/ml < IC50 < 50 microg/ml). Further chemical screening showed that the activity of the most active plant, Sida acuta, was related to its alkaloid contents.
Karou
Damintoti
D
Université de Ouagadougou, Centre de Recherche en Sciences Biologiques, Alimentaires et Nutritionnelles, Laboratoire de Biochimie, 03 BP 7131 Ouagadougou 03, Burkina Faso.
Dicko
Mamoudou H
MH
Sanon
Souleymane
S
Simpore
Jacques
J
Traore
Alfred S
AS
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002478:Cells, Cultured; D029765:Combretum / Q000737:chemistry; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D019660:Malvaceae / Q000737:chemistry*; D016488:Medicine, African Traditional; D029582:Meliaceae / Q000737:chemistry; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D018514:Plant Structures / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D035721:Pterocarpus / Q000737:chemistry*
D000962:Antimalarials; D010936:Plant Extracts