Antihyperglycemic activity of the aqueous extract of Urtica dioica.
When administered 30 min before glucose loading, the aqueous extract of Urtica dioica (nettle) (250 mg/kg) showed a strong glucose lowering effect. The decrease of glycemia has reached to 33+/-3.4% of the control value 1 h after glucose loading. This effect was persistent during 3 h. In contrast, nettle did not show hypoglycemic effect in alloxan-induced diabetic rats. The amount of glucose absorbed in a segment jejunum in situ was 8.05+/-0.68 mg in presence of nettle extract vs. 11.11+/-0.75 mg in control rats during 2 h (P<0.05). The results indicate that nettle has a significant antihyperglycemic effect in OGTT model. This effect may be caused in part by the reduction of intestinal glucose absorption. LD(50) is 3.5 g/kg (i.p.).
Bnouham
Mohamed
M
Laboratoire de Physiologie et Pharmacologie Cellulaire, UFR de Physiologie et Pharmacologie, Département de Biologie, Faculté des Sciences, Université Mohamed Ier, Oujda B.P. 524, Morocco. bnouham@sciences.univ-oujda.ac.ma
Merhfour
Fatima-Zahra
FZ
Ziyyat
Abderrahim
A
Mekhfi
Hassane
H
Aziz
Mohammed
M
Legssyer
Abdelkhaleq
A
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D007583:Jejunum / Q000378:metabolism; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D026982:Urtica dioica
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000496:Alloxan