Diagnosis of Tis/T1 breast cancer extent by multislice helical CT: a novel classification of tumor distribution.
OBJECTIVE
To evaluate the clinical usefulness of multislice helical CT (MSCT) for assessing breast cancer extent.


METHODS
MSCT was performed in 70 patients with Tis/T1 breast cancer [12 ductal carcinoma in situ (DCIS) and 58 invasive carcinoma]. The distribution pattern of contrast enhancement (CE) was classified into five categories: solitary lesion (localized area of CE), grouped lesion (satellite: localized CE with linear and/or spotty enhancement; crowded: clustered spotty enhancement), separated lesion (multifocal foci of CE), mixed lesion (grouped lesion with multifocal foci), and diffuse lesion (diffuse CE).


RESULTS
Solitary lesion was seen in five cases of DCIS, 27 invasive carcinomas without intraductal spread (IDS), six invasive carcinomas with IDS, and one multicentric cancer. Grouped lesion was seen in six DCIS and 15 invasive carcinomas with IDS. Separated lesion was seen in one case of invasive carcinoma and fibroadenoma, and three multifocal/multicentric cancers. Mixed lesion was seen in two multicentric cancers. Diffuse lesion was seen in one case of DCIS and three invasive carcinomas. The coincident rate between MSCT pattern and histologic distribution was 85.7% (60/70). In solitary and grouped lesions, accuracy for the detection of tumor extent with a deviation of less than 2 cm in length was 91.7% (55/60).


CONCLUSIONS
MSCT is extremely accurate in the diagnosis of IDS and the multicentricity of breast cancer.
Tozaki
Mitsuhiro
M
Department of Radiology, Jikei University School of Medicine, Tokyo, Japan.
Kawakami
Makio
M
Suzuki
Masafumi
M
Uchida
Ken
K
Yamashita
Akinori
A
Fukuda
Kunihiko
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology; D018567:Breast Neoplasms, Male / Q000145:classification / Q000000981:diagnostic imaging / Q000473:pathology; D002277:Carcinoma / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000145:classification / Q000000981:diagnostic imaging* / Q000473:pathology; D003287:Contrast Media; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000145:classification / Q000000981:diagnostic imaging / Q000473:pathology; D036542:Tomography, Spiral Computed
D003287:Contrast Media