title: Involvement of gicerin, a cell adhesion molecule, in development and regeneration of chick sciatic nerve.
abstract: We have examined the role of gicerin, an immunoglobulin superfamily cell adhesion molecule, in chick sciatic nerves during development and regeneration. Gicerin was expressed in the spinal cord, dorsal root ganglion (DRG) and sciatic nerves in embryos, but declined after hatching. Neurite extensions from explant cultures of the DRG were promoted on gicerin's ligands, which were inhibited by an anti-gicerin antibody. Furthermore, gicerin expression was upregulated in the regenerating sciatic nerves, DRG and dorsal horn of the spinal cord after injury to the sciatic nerve. These results indicate that gicerin might participate in the development and regeneration of sciatic nerves.
authors: Department of Veterinary Anatomy, Osaka Prefecture University, Graduate School of Agriculture and Biological Sciences, 1-1 Gakuencho, Sakai, Osaka 599-8531, Japan.
authors: Satoshi
authors: S
authors: Hiroi
authors: Yasuhiro
authors: Y
authors: Tsukamoto
authors: Fumihiko
authors: F
authors: Sasaki
authors: Naomasa
authors: N
authors: Miki
authors: Eiichi
authors: E
authors: Taira
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D030161:Avian Proteins; D015153:Blotting, Western; D051929:CD146 Antigen; D002352:Carrier Proteins / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*; D002642:Chick Embryo; D002645:Chickens; D046508:Culture Techniques; D005727:Ganglia, Spinal / Q000196:embryology / Q000502:physiology / Q000648:ultrastructure; D007150:Immunohistochemistry / Q000379:methods; D009416:Nerve Regeneration / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D016501:Neurites / Q000502:physiology; D012584:Sciatic Nerve / Q000196:embryology* / Q000293:injuries / Q000502:physiology* / Q000648:ultrastructure; D013116:Spinal Cord / Q000196:embryology / Q000502:physiology / Q000648:ultrastructure; D013194:Staining and Labeling
chemical_list: D030161:Avian Proteins; D051929:CD146 Antigen; D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; D009419:Nerve Tissue Proteins; C086935:gicerin protein, Gallus gallus