[Improved method of fluvoxamine synthesis].
To modify the synthetic method of fluvoxamine.



Fluvoxamine was synthesized from 4-trifluoromethylbenzonitrile by the steps of Grignard reaction, hydrolysis and oximation.



The chemical structure of the synthesized product was confirmed by (1)HNMR, and the total yield reached to 36.16%.



The results indicate that the synthetic route is practical.
Liu
Tao
T
College of Pharmaceutical Sciences  Zhejiang University, Hangzhou 310031 China.
Sheng
Rong
R
Hu
Yong-zhou
YZ
D016666:Fluvoxamine / Q000138:chemical synthesis*; D017367:Selective Serotonin Reuptake Inhibitors / Q000138:chemical synthesis*
D016666:Fluvoxamine; D017367:Selective Serotonin Reuptake Inhibitors