title: Pneumocystis carinii pneumonia: a late presentation following treatment for stage IV neuroblastoma.
abstract: This report describes a child who develops Pneumocystis carinii pneumonia 7 months after high-dose chemotherapy for stage IV neuroblastoma. In addition to chemotherapy the child had also been treated with abdominal radiotherapy and 13-cis-retinoic acid. Standard practice has been to treat patients with prophylactic co-trimoxazole for 3 months after high-dose therapy, but this report highlights the intensity and complexity of current treatment for stage IV neuroblastoma and the need to be aware of prolonged lymphopenia after such treatment.
authors: Department of Paediatric Oncology, St. James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.
authors: Edward
authors: E
authors: Clarke
authors: Adam W
authors: AW
authors: Glaser
authors: Susan V
authors: SV
authors: Picton
mesh_terms: D000008:Abdominal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D015474:Isotretinoin / Q000627:therapeutic use; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D009894:Opportunistic Infections / Q000188:drug therapy / Q000209:etiology*; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy / Q000209:etiology*; D018714:Radiotherapy, Adjuvant; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000305:Adrenal Cortex Hormones; D014750:Vincristine; D005047:Etoposide; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D003520:Cyclophosphamide; D016190:Carboplatin; D015474:Isotretinoin; D002945:Cisplatin