Myosin V motor proteins: marching stepwise towards a mechanism.
Mammalian myosin V motors transport cargo processively along actin filaments. Recent biophysical and structural studies have led to a detailed understanding of the mechanism of myosin V, making it perhaps the best understood cytoskeletal motor. In addition to describing the mechanism, this review will illustrate how "dynamic" single molecule measurements can synergize with "static" protein structural studies to produce amazingly clear information on the workings of a nanometer-scale machine.
Vale
Ronald D
RD
Department of Cellular and Molecular Pharmacology and The Howard Hughes Medical Institute, University of California, San Francisco, CA 94107, USA. vale@cmp.ucsf.edu
D008841:Actin Cytoskeleton / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001665:Binding Sites / Q000502:physiology; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D020409:Molecular Motor Proteins / Q000378:metabolism*; D024701:Myosin Type V / Q000378:metabolism*; D017434:Protein Structure, Tertiary / Q000502:physiology
D020409:Molecular Motor Proteins; D000251:Adenosine Triphosphatases; D024701:Myosin Type V