Direct mass spectrometric monitoring of solid phase organic syntheses.
Direct on-bead monitoring of solid-phase reactions is possible with soft laser desorption time-of-flight mass spectrometry (SLD-TOF MS) without prior cleavage from the resin if photocleavable phenacyl ester or o-nitroveratryl linker groups are employed.
Gerdes
Jantje M
JM
Max-Planck-Institut für molekulare Physiologie, Abt. Chemische Biologie, Otto-Hahn-Strasse 11, D-44227 Dortmund, Germany.
Waldmann
Herbert
H
D013058:Mass Spectrometry / Q000379:methods; D009930:Organic Chemicals / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*
D009930:Organic Chemicals