title: The use of tranexamic acid to reduce blood loss during total knee arthroplasty.
abstract: OBJECTIVE
  The fall in haemoglobin following unilateral total knee arthroplasty is reduced by tranexamic acid administration.
  
  
  METHODS
  60 patients were studied in total, 30 received tranexamic acid 10 mg/kg on induction and a further dose shortly before the release of the tourniquet. Surgery was performed by the senior author in a standardised fashion using the Freeman Samuelson cemented total knee replacement. Haemoglobin levels were measured 2 weeks pre and 3 days post operatively. Any complications were noted. A control group was matched using the Bone and Joint Research Unit database for age, sex, disease and pre-operative haemoglobin level. This group had been monitored in the same way as the group treated with tranexamic acid.
  
  
  RESULTS
  In the group receiving no tranexamic acid the mean fall in haemoglobin was 2.8 g/dl (95% CI of mean 2.5-3.2) and in the group treated with tranexamic acid 1.7 g/dl (95% CI of mean 1.3-2) P<0.01. There were no complications in either group.
  
  
  CONCLUSIONS
  The administration of tranexamic acid is an effective method of reducing the haemoglobin fall following knee arthroplasty.
authors: Bone and Joint Research Unit, The Royal London Hospital, Whitechapel, London, UK. mchynes@hotmail.com
authors: M
authors: M
authors: Hynes
authors: P
authors: P
authors: Calder
authors: G
authors: G
authors: Scott
mesh_terms: D000368:Aged; D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D019645:Arthroplasty, Replacement, Knee; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D001843:Bone Cements; D016022:Case-Control Studies; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D014111:Tourniquets; D014148:Tranexamic Acid / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000933:Antifibrinolytic Agents; D001843:Bone Cements; D006454:Hemoglobins; D014148:Tranexamic Acid