[Primary aldosteronism. A risk factor for aortic dissection?].
Aortic dissection is a rare but severe disease. Numerous risk factors have been reported, all leading to an alteration of arterial structures, particularly extracellular matrix. Aortic dissection is a complication of arterial hypertension, whatever its origin. Primary aldosteronism, frequent cause of secondary arterial hypertension, is associated with arterial structural alterations, indirectly by a pressure factor, and directly by aldosterone, which modifies collagen contents and elastin/collagen ratios. In addition to the three previously reported cases, the three cases reported in the present paper lead to the hypothesis of a causal relationship between aldosteronism and aortic dissection. The need for hypertension screening and diagnosis of its potential causes, namely primary aldosteronism, is highlighted.
Tartière
J-M
JM
Centre de Diagnostic, Hôpital Hôtel-Dieu, 1, place du Parvis Notre-Dame, 75181 Paris 04.
Kesri
L
L
Mourad
J-J
JJ
Safar
M
M
Blacher
J
J
D000306:Adrenal Cortex Neoplasms / Q000150:complications / Q000378:metabolism; D018246:Adrenocortical Adenoma / Q000150:complications / Q000378:metabolism; D000328:Adult; D000450:Aldosterone / Q000378:metabolism / Q000494:pharmacology; D000784:Aortic Dissection / Q000453:epidemiology* / Q000209:etiology; D001014:Aortic Aneurysm / Q000453:epidemiology*; D001019:Aortic Rupture / Q000453:epidemiology; D003094:Collagen / Q000187:drug effects; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications / Q000453:epidemiology*; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D000450:Aldosterone; D003094:Collagen