Electric field of a six-needle array electrode used in drug and DNA delivery in vivo: analytical versus numerical solution.
We present an analytical solution for the electrical potential and field established by a six-needle array electroporation electrode, which is used in vivo for cancer treatment and DNA delivery. The analytical solution closely matches the numerical solution obtained with the finite element method: the mean error is less than 0.6%.
Dev
Sukhendu B
SB
Gene Delivery & Expression Sciences, San Diego, CA 92122, USA.
Dhar
Deepak
D
Krassowska
Wanda
W
D003198:Computer Simulation; D003238:Connective Tissue / Q000502:physiology*; D004247:DNA / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D004566:Electrodes; D004574:Electromagnetic Fields; D018274:Electroporation / Q000295:instrumentation / Q000379:methods*; D019544:Equipment Failure Analysis / Q000379:methods; D020342:Finite Element Analysis; D015316:Genetic Therapy / Q000379:methods; D008954:Models, Biological; D009339:Needles; D011874:Radiometry / Q000379:methods*; D014162:Transfection / Q000379:methods
D004247:DNA