Wee1-dependent mechanisms required for coordination of cell growth and cell division.
Wee1-related kinases function in a highly conserved mechanism that controls the timing of entry into mitosis. Loss of Wee1 function causes fission yeast and budding yeast cells to enter mitosis before sufficient growth has occurred, leading to formation of daughter cells that are smaller than normal. Early work in fission yeast suggested that Wee1 is part of a cell-size checkpoint that prevents entry into mitosis before cells have reached a critical size. Recent experiments in fission yeast and budding yeast have provided new support for this idea. In addition, studies in budding yeast have revealed the existence of highly intricate signaling networks that are required for regulation of Swe1, the budding yeast homolog of Wee1. Further understanding of these signaling networks may provide important clues to how cell growth and cell division are coordinated.
Kellogg
Douglas R
DR
Sinsheimer Laboratories, Department of Molecular, Cellular and Developmental Biology, University of California, Santa Cruz, CA 95064, USA. kellogg@darwin.ucsc.edu
D018797:Cell Cycle Proteins / Q000378:metabolism; D002455:Cell Division / Q000502:physiology*; D048429:Cell Size / Q000502:physiology; D004790:Enzyme Induction / Q000502:physiology; D005656:Fungal Proteins / Q000378:metabolism; D008938:Mitosis; D009687:Nuclear Proteins; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins; D004718:Saccharomycetales / Q000378:metabolism; D012568:Schizosaccharomyces / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins; D020666:ras-GRF1 / Q000378:metabolism
D018797:Cell Cycle Proteins; D005656:Fungal Proteins; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; D020666:ras-GRF1; C099685:SWE1 protein, S cerevisiae; C068689:wee1 protein, S pombe; D011505:Protein-Tyrosine Kinases; D010744:Phosphoric Monoester Hydrolases