A randomized trial of yogurt for prevention of antibiotic-associated diarrhea.
Antibiotic-associated diarrhea (AAD) is the most common adverse effect of antibiotic therapy. Our aim was to determine the effectiveness of a dietary supplement of yogurt for prevention of AAD. Two hundred two hospitalized patients receiving oral or intravenous antibiotics were randomized to receive or not receive a dietary yogurt supplement, consisting of 227 grams of commercial yogurt, and followed for 8 days. Mean age of the study group was 70 years and 43% were male. Compliance and 8-day follow-up were 85% and 91%, respectively. Patients receiving yogurt reported less frequent diarrhea (12% vs 24%; P = 0.04), and significantly less total diarrhea] days (23 vs 60). The cumulative proportions of patients without diarrhea were significantly different (P = 0.02) between patients receiving and not receiving yogurt. For conclusion, dietary supplementation with yogurt is a simple, effective, and safe treatment that decreases the incidence and duration of AAD.
Beniwal
Ripudaman S
RS
Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Roudebush VA Medical Center, (11H) 1481 W. 10th Street, Indianapolis, Indiana 46202, USA. rbeniwal@iupui.edu
Arena
Vincent C
VC
Thomas
Leno
L
Narla
Sudhir
S
Imperiale
Thomas F
TF
Chaudhry
Rauf A
RA
Ahmad
Usman A
UA
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003967:Diarrhea / Q000139:chemically induced* / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D015994:Incidence; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D015014:Yogurt
D000900:Anti-Bacterial Agents