title: Identification of a new HLA-DRB5 allele, DRB5*0112, by routine PCR-SSP.
abstract: We describe the identification of a new HLA-DRB5 allele found in two members of a British Caucasoid family. Genomic analysis of exon 2 revealed a novel sequence. The name DRB5*0112 has been assigned to this allele by the WHO Nomenclature Committee, and the EMBL sequence database accession number for this is AJ427352. DRB5*0112 has several unique sequence features when compared to other DRB5 alleles, and comparison with all known DRB1/3/4/5 alleles indicates this to have arisen as a result of intraexonic recombination between a DRB5-containing haplotype and one carrying DRB1*09.
authors: Histocompatibility and Immunogenetics Laboratory, National Blood Service, Vincent Drive, Edgbaston, Birmingham, UK. david.atkinson@nbs.nhs.uk
authors: D C
authors: DC
authors: Atkinson
authors: S E
authors: SE
authors: Jobson
authors: P P J
authors: PP
authors: Dunn
authors: D C
authors: DC
authors: Briggs
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D005091:Exons; D006684:HLA-DR Antigens / Q000235:genetics*; D059847:HLA-DRB5 Chains; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D006684:HLA-DR Antigens; D059847:HLA-DRB5 Chains