[Intratumoral administration of methotrexate bound to activated carbon particles (MTX-CH) inducing antitumor effect in vivo].
Methotrexate is one of the anticancer drugs that can be safely administered subcutaneously, but locally injected MTX in aqueous solution form does not function in the administration site for very long. We developed a new dosage formulation: methotrexate bound to activated carbon particles (MTX-CH), and can report that it controlled tumor growth through its long-acting effect at the administration site. In this study, we investigated the effect of local administration of MTX-CH compared with MTX aqueous solution in tumors from transplanted human colon cancer cells (LoVo) into the back of nude mice. MTX-CH is superior to MTX aqueous solution in terms of its long-acting effect at the administration site and antitumor effect. We suggest that intratumoral injection therapy of MTX-CH is useful for patients in poor condition and with high surgical risk due to cardiac disease or old age, and patients who are diagnosed positive for cancer after endoscopic mucosal resection of early colorectal cancer.
Nakase
Yuen
Y
Dept. of Digestive Surgery, Kyoto Prefectural University of Medicine.
Kin
Syuichi
S
Fukuda
Ken-ichirou
K
Takagi
Tsuyoshi
T
Shimomura
Katsumi
K
Ito
Tadao
T
Sakakura
Chohei
C
Otsuji
Eigo
E
Ueda
Yuji
Y
Sonoyama
Teruhisa
T
Itoi
Hirosumi
H
Hagiwara
Akeo
A
Yamagishi
Hisakazu
H
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000737:chemistry; D002244:Carbon; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D003692:Delayed-Action Preparations; D005260:Female; D015552:Injections, Intralesional; D008727:Methotrexate / Q000008:administration & dosage* / Q000737:chemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D013047:Specific Pathogen-Free Organisms
D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D002244:Carbon; D008727:Methotrexate