[Allorecognition of the recipient after hematopoietic transplantation].
Donor allorecognition of the recipient after hematopoietic transplantation can result in graft-versus-host disease, a potent graft-vs-leukemia effect as well as a graft facilitation effect. Danger signals, host Ag-presenting cells and minor histocompatibility Ag have recently emerged as major determinants of such an alloreactivity. A better understanding of the involved immune mechanisms, the development of novel immunomonitoring tools and cell engineering approaches should result in a significantly increased therapeutic index of allogeneic alloreactivity.
Tiberghien
Pierre
P
Inserm E 0119/MEN EA 2284, EFS Bourgogne, Franche-Comté, 1 bd Fleming, 25000 Besançon, France.
Robinet
Eric
E
Ferrand
Christophe
C
Saas
Philippe
P
Hervé
Patrick
P
D000938:Antigen-Presenting Cells / Q000276:immunology; D006086:Graft vs Host Disease / Q000276:immunology*; D020544:Graft vs Leukemia Effect / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006648:Histocompatibility; D006801:Humans; D007111:Immunity, Cellular; D015778:Minor Histocompatibility Antigens / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D015778:Minor Histocompatibility Antigens