[A case of gastric cancer with peritoneal dissemination which showed the intraperitoneal CR by administrating TS-1 orally and paclitaxel intraperitoneally].
A 66-year-old male was diagnosed with advanced gastric cancer with pylorus stenosis, and the first abdominal computed tomography (CT) revealed a large amount of ascites. A staging laparoscopy revealed peritoneal dissemination and positive cytology for numerous amounts of ascites (s-T3(SE), N0, M0, p(+), cy(+), H0, s-Stage IV). The patient received TS-1 orally and paclitaxel administered to the peritoneal cavity. After finishing the second course of the combined chemotherapy, second-look staging laparoscopy was performed, which showed the disappearance of peritoneal dissemination and negative cytology. Chemotherapy combined with oral TS-1 and paclitaxel administered to the peritoneal cavity might be an effective strategy against advanced gastric cancer with peritoneal dissemination.
Miki
Hirofumi
H
Dept. of Surgery, Kansai Rosai Hospital.
Tamura
Shigeyuki
S
Wada
Hiroshi
H
Kozuma
Yasuyuki
Y
Kittaka
Nobuyoshi
N
Kim
Tyuwan
T
Takiuchi
Daisuke
D
Aihara
Tomohiko
T
Sugimoto
Keiji
K
Fukunaga
Mutsumi
M
Ozato
Hiroki
H
Tomita
Naohiro
N
Takatsuka
Yuichi
Y
D000284:Administration, Oral; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D010094:Oxonic Acid / Q000008:administration & dosage; D017239:Paclitaxel / Q000008:administration & dosage; D010529:Peritoneal Cavity; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D011725:Pyridines / Q000008:administration & dosage; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000473:pathology*; D005641:Tegafur / Q000008:administration & dosage
D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D017239:Paclitaxel