title: Current developments in SELDI affinity technology.
abstract: The overall history and recent advancements in Surface-Enhanced Laser Desorption/Ionization (SELDI) affinity technology is reviewed. A detailed account of SELDI technology, utilizing Immobilized-Metal Affinity surfaces, pseudo-specific chromatographic surfaces, and biospecific interactive surfaces, is presented with particular emphasis placed upon examination of fundamental characteristics as well as specific applications for each. Finally, a detailed review of the specific use of such affinity surfaces in fundamental aspects of clinical, process, and research proteomics activity is presented.
authors: Ciphergen Biosystems, 6611 Dumbarton Circle, Fremont, California 94555, USA.
authors: Ning
authors: N
authors: Tang
authors: Pete
authors: P
authors: Tornatore
authors: Scot R
authors: SR
authors: Weinberger
mesh_terms: D015336:Molecular Probe Techniques / Q000639:trends; D015335:Molecular Probes / Q000138:chemical synthesis / Q000737:chemistry*; D040081:Protein Array Analysis / Q000379:methods* / Q000639:trends*; D011506:Proteins / Q000032:analysis* / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods* / Q000639:trends*
chemical_list: D015335:Molecular Probes; D011506:Proteins