title: Bridging use of plasma exchange and continuous hemodiafiltration before living donor liver transplantation in fulminant Wilson's disease.
abstract: A 15-year-old girl presented with acute hepatic failure showing ascites and hepatic encephalopathy, accompanied by hemolytic anemia. She was diagnosed as having fulminant Wilson's disease (FWD). Plasma exchange (PE), continuous hemodiafiltration (CHDF) and D-penicillamine administration were started immediately. Copper [24,000 microg] was removed by PE and CHDF over three days, which relieved the jaundice and the consciousness disorder. A successful liver transplant followed. FWD progresses rapidly and often liver transplantation is the only possible therapy. In this case, PE and CHDF were an effective therapy bridge until liver transplantation.
authors: Department of Internal Medicine II, Miyazaki Medical College, Kiyotake.
authors: Yoshiko
authors: Y
authors: Nagata
authors: Hirofumi
authors: H
authors: Uto
authors: Satoru
authors: S
authors: Hasuike
authors: Akio
authors: A
authors: Ido
authors: Katsuhiro
authors: K
authors: Hayashi
authors: Toshiharu
authors: T
authors: Eto
authors: Toshiro
authors: T
authors: Hamakawa
authors: Koichi
authors: K
authors: Tanaka
authors: Hirohito
authors: H
authors: Tsubouchi
mesh_terms: D000293:Adolescent; D002614:Chelating Agents / Q000627:therapeutic use; D005260:Female; D017583:Hemodiafiltration / Q000379:methods*; D006527:Hepatolenticular Degeneration / Q000150:complications / Q000601:surgery / Q000628:therapy*; D006801:Humans; D017093:Liver Failure / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D016031:Liver Transplantation; D019520:Living Donors; D010396:Penicillamine / Q000627:therapeutic use; D010951:Plasma Exchange / Q000379:methods*; D011300:Preoperative Care; D016896:Treatment Outcome
chemical_list: D002614:Chelating Agents; D010396:Penicillamine