Calcineurin anchoring and cell signaling.
The targeting of phosphatase PP2B or calcineurin toward certain substrates synchronizes a variety of physiological processes. This review emphasizes how the targeting of calcineurin through interaction with various anchoring proteins facilitates phosphatase regulation of T-cell activation, neuronal excitability and cardiac hypertrophy.
Dodge
Kimberly L
KL
Howard Hughes Medical Institute, Vollum Institute, Oregon Health and Sciences University, Portland, OR, USA.
Scott
John D
JD
D000818:Animals; D001665:Binding Sites; D019703:Calcineurin / Q000378:metabolism*; D006332:Cardiomegaly / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D009124:Muscle Proteins / Q000378:metabolism*; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D011485:Protein Binding; D018091:Receptors, AMPA / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism*
D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009124:Muscle Proteins; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; C108612:RCAN1 protein, human; D018091:Receptors, AMPA; D014157:Transcription Factors; D019703:Calcineurin