Palladium-catalyzed amidation of enol triflates: a new synthesis of enamides.
[reaction: see text] The palladium-catalyzed coupling of a range of enol triflates with amides, carbamates, and sulfonamides has been developed. This offers a simple and widely applicable synthesis of enamides, which may not be readily available by other means.
Wallace
Debra J
DJ
Department of Process Research, Merck Research Laboratories, P. O. Box 2000, Rahway, New Jersey 07065, USA. debra_wallace@merck.com
Klauber
David J
DJ
Chen
Cheng-yi
CY
Volante
Ralph P
RP