[Movement disorders in childhood: classification and genetic update].
Abnormal movements are not unusual in childhood. Recent genetic progresses provide a new approach of childhood movement disorders. Several loci have been identified in paroxysmal dyskinesia, or in Gilles de la Tourette syndrome. A gene has been cloned in Hallervorden-Spatz syndrome, and a gene has recently been implicated in benign hereditary chorea. Considerable advances concern the genetic of dystonic syndromes: several chromosomal localizations have been identified, and several genes have been cloned. Genetic advances allow nosographic reclassification of some entities and offer new molecular tools for a more appropriate diagnosis. The increasing wealth of genetic knowledge will provide further insight in the understanding of abnormal movement disorders in childhood.
Roubertie
A
A
Service de neuropédiatrie, hôpital Saint-Eloi, 80, avenue Augustin-Fliche, 34295 cedex 5 Montpellier, France. a_roubertie@hotmail.com
Rivier
F
F
Tuffery-Giraud
S
S
Humbertclaude
V
V
Claustres
M
M
Cheminal
R
R
Echenne
B
B
D002648:Child; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D009069:Movement Disorders / Q000145:classification* / Q000235:genetics*