Metabolism of D-glucose anomers in pancreatic islets (review).
D-glucose metabolism displays anomeric specificity in pancreatic islets and other cell types. Recent studies have extended this knowledge to the effect of D-glucose to augment D-fructose phosphorylation by glucokinase in both pancreatic islet B-cells and hepatocytes, and have documented that the anomeric specificity of D-glucose metabolism in pancreatic islets implies enzyme-to-enzyme tunnelling of metabolites in the early steps of glycolysis. It is proposed that the anomeric specificity of D-glucose metabolism is essential to a sound understanding of carbohydrate homeostasis in health and disease.
Malaisse
Willy J
WJ
Laboratory of Experimental Hormonology, Brussels Free University, Route de Lennik 808, B-1070 Brussels, Belgium. malaisse@ulb.ac.be
D000818:Animals; D005632:Fructose / Q000378:metabolism; D005941:Glucokinase / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007515:Islets of Langerhans / Q000378:metabolism*; D007536:Isomerism
D005632:Fructose; D005941:Glucokinase; D005947:Glucose