title: Mechanics of breathing after surgical ligation of patent ductus arteriosus in newborns with respiratory distress syndrome.
abstract: The aim of the study was to detect changes in pulmonary function following ligation of a patent ductus arteriosus (PDA). Pulmonary function was recorded in 16 newborns (birth weight 1,081 +/- 166 g, gestational age 27.6 +/- 1.7 weeks) before and after ligation. No change in resistance of airways or mean airway pressure was observed. We found an increase in dynamic compliance (Cdyn) of 77% (p < 0.01), in tidal volume (TV) of 29% (p = 0.004), and in minute ventilation (MV) of 17% (p < 0.01) after the procedure. We demonstrated that pulmonary function improves after surgical ligation of the PDA. Because of considerable variation in intubated and spontaneously breathing premature newborns, we recommend the analysis of three main parameters: Cdyn, TV and MV for estimation of pulmonary mechanics in these infants.
authors: Department of Neonatology, University of Medical Sciences, Poznań, Poland. mszymank@gpsk.am.poznan.pl
authors: Marta
authors: M
authors: Szymankiewicz
authors: Joan E
authors: JE
authors: Hodgman
authors: Bijan
authors: B
authors: Siassi
authors: Janusz
authors: J
authors: Gadzinowski
mesh_terms: D000403:Airway Resistance; D001724:Birth Weight; D004374:Ductus Arteriosus, Patent / Q000601:surgery*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008026:Ligation; D008170:Lung Compliance; D008297:Male; D012121:Respiration, Artificial; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology*; D015656:Respiratory Mechanics / Q000502:physiology*; D013990:Tidal Volume; D016896:Treatment Outcome