Possible mechanisms underlying the effect of natural preparations on erythropoiesis under conditions of conflict situation.
We studied the effects of various natural preparations, including extracts of Siberian ginseng, Rhodiola rosea, bergenia, and ginseng and pantohematogen on erythropoiesis under conditions of conflict situation. The test preparations were divided into 2 groups depending on their modulatory effect on intensified erythropoiesis under conditions of conflict situation. Some of them reduced (extracts of ginseng, bergenia, and Rhodiola rosea), while others increased the degree of hyperplasia in the erythropoietic stem (extract of Siberian ginseng and pantohematogen). The regulatory effect of preparations depended on activity of the corresponding neurotransmitter systems in the brain and local regulatory mechanisms of hemopoiesis.
Provalova
N V
NV
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Skurikhin
E G
EG
Pershina
O V
OV
Minakova
M Yu
MY
Suslov
N I
NI
Dygai
A M
AM
D000818:Animals; D001685:Biological Factors / Q000737:chemistry / Q000494:pharmacology*; D003220:Conflict, Psychological; D004920:Erythropoiesis / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D005894:Panax / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D029771:Rhodiola / Q000737:chemistry; D013234:Stem Cells / Q000166:cytology / Q000502:physiology
D001685:Biological Factors; D010936:Plant Extracts; C404022:pantohematogen