Asymmetric conjugate addition reactions of Meldrum's acid derived acceptors employing chiral phosphoramidite ligands.
[reaction: see text] The enantioselective conjugate addition reaction of Et(2)Zn to Meldrum's acid derived acceptors, mediated by a catalyst formed from Cu(O(2)CCF(3))(2) and a phosphoramidite ligand, is reported. Adducts are obtained in useful yields and up to 94% ee.
Watanabe
Takumi
T
Laboratorium für Organische Chemie, ETH-Hönggerberg HCI H335, CH-8093 Zürich, Switzerland.
Knöpfel
Thomas F
TF
Carreira
Erick M
EM