Glucose-regulated stress proteins and antibacterial immunity.
The role of stress proteins in immunity and their feasibility as vaccine vehicles against infectious disease have been the focus of intensive examination. Endoplasmic reticulum (ER)-resident stress proteins in particular are interesting model proteins as they perform crucial functions in an organelle that responds promptly to cell stress. We describe transcriptional regulation of ER-resident stress proteins, their involvement in the cellular response to infection and discuss their potential as vaccine candidates against infectious diseases.
Rapp
Ulrike K
UK
Max Planck Institute for Infection Biology, Schumannstrasse 21-22, 10117 Berlin, Germany. rapp@mpiib-berlin.mpg.de
Kaufmann
Stefan H E
SH
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D015551:Autoimmunity; D001692:Biological Transport; D004721:Endoplasmic Reticulum / Q000276:immunology* / Q000378:metabolism; D005786:Gene Expression Regulation; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology*; D011401:Promoter Regions, Genetic
D018840:HSP70 Heat-Shock Proteins; D008565:Membrane Proteins; C018551:glucose-regulated proteins