Human metapneumovirus infection in Thai children.
Human metapneumovirus (hMPV) associated with clinical respiratory tract infection (RTI) in children was first isolated in The Netherlands. Of 120 Thai paediatric patients with RTI examined, 5 cases (4.2%) showed detectable hMPV based on N-gene-specific RT-PCR. All of them were negative for hRSV infection. Aligning the sequences with a reference strain revealed some nucleotide differences, which necessitates future investigation to evaluate clinical significance and genotype variation.
Thanasugarn
Wanida
W
Viral Hepatitis Research Unit, Department of Paediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Samransamruajkit
Rujipat
R
Vanapongtipagorn
Pijitra
P
Prapphal
Nuanchan
N
Van den Hoogen
Bernadette
B
Osterhaus
Albert D M E
AD
Poovorawan
Yong
Y
D000293:Adolescent; D001483:Base Sequence; D002648:Child; D002675:Child, Preschool; D005260:Female; D005784:Gene Amplification; D006801:Humans; D007223:Infant; D008297:Male; D029121:Metapneumovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D008969:Molecular Sequence Data; D018184:Paramyxoviridae Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D015995:Prevalence; D012367:RNA, Viral / Q000032:analysis; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012621:Seasons; D016415:Sequence Alignment; D013785:Thailand / Q000453:epidemiology
D012367:RNA, Viral