Pre-synaptic kainate receptors in GABAergic and glutamatergic axon terminals in the monkey globus pallidus.
Although the localization and role of kainate receptors in the CNS remain poorly known, complex, and rather unusual, pre-synaptic auto- and heteroreceptor functions have been disclosed in various brain regions. Basal ganglia nuclei, including the globus pallidus, are enriched in GluR6/7 immunoreactivity. Using electron microscopic immunocytochemistry for GluR6/7 combined with post-embedding immunogold labeling for GABA, we demonstrate that GluR6/7 immunoreactivity is enriched in a large subpopulation of small unmyelinated, presumably pre-terminal, axons as well as GABAergic and putative glutamatergic axon terminals in the internal and external segments of the globus pallidus in monkey. Our findings suggest that kainate receptors are located to subserve pre-synaptic modulation of inhibitory and excitatory transmission in the primate globus pallidus.
Kane-Jackson
R
R
Division of Neuroscience, Yerkes National Primate Research Center and Department of Neurology, Emory University, 954, Gatewood Road Northeast, Atlanta, GA 30322, USA.
Smith
Y
Y
D000818:Animals; D005917:Globus Pallidus / Q000737:chemistry* / Q000648:ultrastructure; D018698:Glutamic Acid / Q000032:analysis*; D008253:Macaca mulatta; D017729:Presynaptic Terminals / Q000737:chemistry* / Q000648:ultrastructure; D018092:Kainic Acid Receptors / Q000032:analysis* / Q000648:ultrastructure; D017661:Receptors, Presynaptic / Q000032:analysis / Q000648:ultrastructure; D005680:gamma-Aminobutyric Acid / Q000032:analysis*; D000097806:GluK2 Kainate Receptor; D000097808:GluK3 Kainate Receptor
D018698:Glutamic Acid; D018092:Kainic Acid Receptors; D017661:Receptors, Presynaptic; D005680:gamma-Aminobutyric Acid; D000097806:GluK2 Kainate Receptor; D000097808:GluK3 Kainate Receptor