title: [Postoperative adjuvant intraarterial chemotherapy of combined cisplatin and 5-FU for advanced hepatocellular carcinoma].
abstract: Postoperative adjuvant intraarterial infusion chemotherapy was performed for 22 hepatectomized patients with Stage III and Stage IV-A hepatocellular carcinoma from July, 1997, to December, 1999. One course of this chemotherapy consisted of cisplatin (10 mg/body/day on days 1-5) followed by 5-FU (250 mg/body/day on days 1-5). One hundred forty-eight patients of Stage III and Stage IV-A underwent hepatectomy from 1992 to 2001 and were enrolled as historical control. There were 9 Stage III cases treated with this adjuvant chemotherapy, and there were 7 or 6 Stage IV-A cases with and without main portal thrombosis, respectively. Survival and disease-free survival curves were not improved compared to historical control by this adjuvant chemotherapy. The number of recurrences in the remnant liver of 2 Stage IV-A cases with main portal thrombosis was limited to 3. Those cases treated with rehepatectomy and transarterial chemoembolization survived about 1,200 days without tumor recurrence.
authors: Dept. of General Surgery, Hokkaido University Graduate School.
authors: Toshiya
authors: T
authors: Kamiyama
authors: Takahito
authors: T
authors: Nakagawa
authors: Kazuaki
authors: K
authors: Nakanishi
authors: Nobuaki
authors: N
authors: Kurauchi
authors: Hirohumi
authors: H
authors: Kamachi
authors: Michiaki
authors: M
authors: Matsushita
authors: Satoru
authors: S
authors: Todo
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006498:Hepatectomy; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D009367:Neoplasm Staging; D011182:Postoperative Care; D011379:Prognosis
chemical_list: D002945:Cisplatin; D005472:Fluorouracil