title: Hepatitis B virus gene in liver tissue promotes hepatocellular carcinoma development in chronic hepatitis C patients.
abstract: The hepatitis B virus (HBV) gene has been detected in hepatocellular carcinoma (HCC) tissue negative for the hepatitis B surface antigen and positive for the hepatitis C virus (HCV) antibody, but the precise role of the HBV gene in hepatocarcinogenesis has yet to be clarified. We studied the HBV gene in liver tissue several years before the emergence of HCC. Eleven patients diagnosed with HCV-positive chronic liver disease and who developed HCC were assigned to group A. HBV DNA was detected in 8 of the 11 patients (73%). Twenty-five patients, who did not develop HCC, were selected as group B. Six of the group B patients were classified as DNA-positive (24%). The HBV DNA in liver tissue was found to be significantly related to HCC development (P < 0.01). Thus, the presence of the HBV gene in patients with chronic HCV associated-liver injury appears to promote hepatocarcinogenesis, although prospective studies are needed to confirm this result.
authors: Department of Laboratory Medicine, Okayama University Medical School, Okayama, Japan.
authors: Shin-Ichi
authors: S
authors: Fujioka
authors: Hiroyuki
authors: H
authors: Shimomura
authors: Yoshiaki
authors: Y
authors: Iwasaki
authors: Kozo
authors: K
authors: Fujio
authors: Hiroshi
authors: H
authors: Nakagawa
authors: Yasuhiro
authors: Y
authors: Onishi
authors: Shinjiro
authors: S
authors: Takagi
authors: Hideaki
authors: H
authors: Taniguchi
authors: Fumi
authors: F
authors: Umeoka
authors: Hirofumi
authors: H
authors: Nakajima
authors: Akio
authors: A
authors: Moriya
authors: Katsuyuki
authors: K
authors: Nanba
authors: Cheng-Yu
authors: CY
authors: Piao
authors: Toshiyuki
authors: T
authors: Shinji
authors: Norio
authors: N
authors: Koide
authors: Yasush
authors: Y
authors: Shiratori
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000821:virology*; D005260:Female; D006515:Hepatitis B virus / Q000235:genetics*; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008099:Liver / Q000821:virology*; D008113:Liver Neoplasms / Q000235:genetics* / Q000821:virology*; D008297:Male; D008875:Middle Aged