Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters.
A series of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters was synthesized and their antimicrobial activity was established. These derivatives exhibit increased activity against VanB resistant strains of bacteria equipotent with that observed with sensitive bacteria.
McComas
Casey C
CC
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Crowley
Brendan M
BM
Hwang
Inkyu
I
Boger
Dale L
DL
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects; D008738:Methyl Ethers / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D012310:Ristocetin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D017334:Teicoplanin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D020713:Vancomycin Resistance
D000890:Anti-Infective Agents; D008738:Methyl Ethers; D012310:Ristocetin; D017334:Teicoplanin; D014640:Vancomycin