title: [Intratumoral administration of methotrexate bound to activated carbon particles (MTX-CH) inducing antitumor effect in vivo].
abstract: Methotrexate is one of the anticancer drugs that can be safely administered subcutaneously, but locally injected MTX in aqueous solution form does not function in the administration site for very long. We developed a new dosage formulation: methotrexate bound to activated carbon particles (MTX-CH), and can report that it controlled tumor growth through its long-acting effect at the administration site. In this study, we investigated the effect of local administration of MTX-CH compared with MTX aqueous solution in tumors from transplanted human colon cancer cells (LoVo) into the back of nude mice. MTX-CH is superior to MTX aqueous solution in terms of its long-acting effect at the administration site and antitumor effect. We suggest that intratumoral injection therapy of MTX-CH is useful for patients in poor condition and with high surgical risk due to cardiac disease or old age, and patients who are diagnosed positive for cancer after endoscopic mucosal resection of early colorectal cancer.
authors: Dept. of Digestive Surgery, Kyoto Prefectural University of Medicine.
authors: Yuen
authors: Y
authors: Nakase
authors: Syuichi
authors: S
authors: Kin
authors: Ken-ichirou
authors: K
authors: Fukuda
authors: Tsuyoshi
authors: T
authors: Takagi
authors: Katsumi
authors: K
authors: Shimomura
authors: Tadao
authors: T
authors: Ito
authors: Chohei
authors: C
authors: Sakakura
authors: Eigo
authors: E
authors: Otsuji
authors: Yuji
authors: Y
authors: Ueda
authors: Teruhisa
authors: T
authors: Sonoyama
authors: Hirosumi
authors: H
authors: Itoi
authors: Akeo
authors: A
authors: Hagiwara
authors: Hisakazu
authors: H
authors: Yamagishi
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000737:chemistry; D002244:Carbon; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D003692:Delayed-Action Preparations; D005260:Female; D015552:Injections, Intralesional; D008727:Methotrexate / Q000008:administration & dosage* / Q000737:chemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D013047:Specific Pathogen-Free Organisms
chemical_list: D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D002244:Carbon; D008727:Methotrexate