title: Array synthesis of novel lipodepsipeptide.
abstract: Synthetic array technology was utilized to rapidly synthesize and analyze a diverse set of reductive alkylation analogues of daptomycin. Analysis of the array suggested the use of polar functionality such as sulfonamides or amide or polar spaces such as piperazine would beneficially affect activity.
authors: Cubist Pharmaceuticals Inc., 65 Hayden Ave., Lexington, MA 02421, USA.
authors: James
authors: J
authors: Siedlecki
authors: Jason
authors: J
authors: Hill
authors: Ian
authors: I
authors: Parr
authors: Xiang
authors: X
authors: Yu
authors: Michael
authors: M
authors: Morytko
authors: Yanzhi
authors: Y
authors: Zhang
authors: Jared
authors: J
authors: Silverman
authors: Nicole
authors: N
authors: Controneo
authors: Valerie
authors: V
authors: Laganas
authors: Tongchuan
authors: T
authors: Li
authors: Jianshi
authors: J
authors: Li
authors: Dennis
authors: D
authors: Keith
authors: George
authors: G
authors: Shimer
authors: John
authors: J
authors: Finn
mesh_terms: D000478:Alkylation; D000577:Amides / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D017576:Daptomycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D015195:Drug Design; D013293:Enterococcus faecalis / Q000187:drug effects; D016984:Enterococcus faecium / Q000187:drug effects; D008055:Lipids / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000494:pharmacology; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000737:chemistry
chemical_list: D000577:Amides; D000900:Anti-Bacterial Agents; D008055:Lipids; D010456:Peptides, Cyclic; D010879:Piperazines; D013449:Sulfonamides; D000077489:Piperazine; D017576:Daptomycin