The metallo-beta-lactamases fall into two distinct phylogenetic groups.
The Ambler Class B metallo-beta-lactamases fall into two distinct phylogenetic groups based on the observation that there is no significant sequence homology between the sequences of members of different groups. Structural alignments confirm that those groups are no more closely related to each other than are the three classes of serine beta-lactamases, Classes A, C, and D. We present phylogenies of these two groups and suggest a new classification scheme for the beta-lactamases.
Hall
Barry G
BG
Biology Department, Hutchison Hall, University of Rochester, Rochester, NY 14627-0211, USA. drbh@mail.rochester.edu
Salipante
Stephen J
SJ
Barlow
Miriam
M
D001419:Bacteria / Q000201:enzymology / Q000235:genetics; D019143:Evolution, Molecular; D010802:Phylogeny; D001618:beta-Lactamases / Q000145:classification* / Q000235:genetics*
D001618:beta-Lactamases