Kinetic evidence for the existence and mechanism of formation of a barrel stave structure from pore-forming dendrimers.
A dendritic approach to the construction of a homologous series of pore-forming amphiphiles has been developed, based on the use of spermidine, spermine, lysine, and cholic acid. A kinetic analysis of Na+ transport across bilayers of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine by three dendritic amphiphiles has provided the strongest evidence to date for a barrel stave structure.
Zhang
Jianbing
J
Department of Chemistry, Lehigh University, Bethlehem, PA 18015, USA.
Jing
Bingwen
B
Regen
Steven L
SL
D019826:Cholic Acid / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry* / Q000378:metabolism; D008081:Liposomes / Q000737:chemistry; D008239:Lysine / Q000737:chemistry; D010713:Phosphatidylcholines / Q000737:chemistry; D011073:Polyamines / Q000737:chemistry*; D012964:Sodium / Q000737:chemistry / Q000378:metabolism; D013095:Spermidine / Q000737:chemistry; D013096:Spermine / Q000737:chemistry; D013329:Structure-Activity Relationship
D008051:Lipid Bilayers; D008081:Liposomes; D010713:Phosphatidylcholines; D011073:Polyamines; D013096:Spermine; D012964:Sodium; D019826:Cholic Acid; D005978:Glutathione; D008239:Lysine; C028694:1-palmitoyl-2-oleoylphosphatidylcholine; D013095:Spermidine