Immobilization with ketamine HCl and tiletamine-zolazepam in cynomolgus monkeys.
To compare the effects of ketamine and tiletamine-zolazepam (TZ) drugs widely used for the chemical restraint and immobilization of primates, on various physiological parameters and blood gas values in cynomolgus monkeys (Macaca facicularis). Rectal temperature, heart rate, respiration rate and blood gas analysis were measured before treatment and at 1, 10, 20, 30, 40, 50 and 60 min after administration. Additionally, in both groups, induction and maintenance times were compared. Heart rate, respiration rate, rectal temperature, pH and pCO2 were not significant different in the two groups. However, pO2 in the ketamine-treated group was significantly lower at 30 and 40 min than in the TZ-treated group. The induction time was short in both groups, and the maintenance time was longer in the TZ-treated group (67.8-/+6.5 min) than in the ketamine-treated group (42.3-/+6.7 min). However, decreased rectal temperatures must be watched and prevented following TZ administration to cynomolgus monkeys. It was considered that ketamine may be useful for short duration anesthesia including handling, physical examination, blood sampling and TZ may be useful for prolonged anesthesia including minor surgery and other surgical procedure.
Lee
Jae-il
JI
Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea.
Hong
Sung-hyeok
SH
Lee
Soo-jin
SJ
Kim
Young-suk
YS
Kim
Myung-cheol
MC
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007103:Immobilization / Q000502:physiology*; D007649:Ketamine / Q000494:pharmacology*; D008252:Macaca fascicularis; D008297:Male; D010313:Partial Pressure; D015656:Respiratory Mechanics; D012149:Restraint, Physical / Q000379:methods*; D013992:Tiletamine / Q000494:pharmacology*; D013997:Time Factors
D018691:Excitatory Amino Acid Antagonists; D002245:Carbon Dioxide; D013992:Tiletamine; D007649:Ketamine