Identification of novel small-molecule Ulex europaeus I mimetics for targeted drug delivery.
Lectin mimetics have been identified that may have potential application towards targeted drug delivery. Synthetic multivalent polygalloyl constructs effectively competed with Ulex europaeus agglutinin I (UEA1) for binding to intestinal Caco-2 cell membranes.
Hamashin
Christa
C
Mixture Sciences, Inc., 3550 General Atomics Court, San Diego, CA 92121, USA.
Spindler
Lisa
L
Russell
Shannon
S
Schink
Amy
A
Lambkin
Imelda
I
O'Mahony
Daniel
D
Houghten
Richard
R
Pinilla
Clemencia
C
D018938:Caco-2 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D018716:Molecular Mimicry; D037121:Plant Lectins / Q000737:chemistry* / Q000494:pharmacology
D037121:Plant Lectins; C036850:Ulex europaeus lectins