A simple tandem repeat polymorphism is present in the eighth intron of FLJ12960, a possible queuine salvage enzyme gene.
The putative gene FLJ12960 was identified from sequence analysis of the human genome and predicted to be a member of the family of tRNA-guanine-transglycosylases for queuine biosynthesis by protein sequence similarity at the Zn-binding site (Locus Link #79691 at http://www.ncbi.nlm.gov/LocusLink/). FLJ12960 is immediately downstream of the Dopamine Receptor D3 (DRD3) gene. A Simple Tandem Repeat (STR) polymorphism was identified in intron 8 of the FLJ12960 gene. Primers designed to amplify the CA repeat detect 16 alleles from 121 to 151 base pairs, with a heterozygosity of 0.74.
Vandenbergh
David J
DJ
Department of Biobehavioral Health, The Pennsylvania State University, 225 Research Building E, 101 Amy Gardener House, University Park, PA 16802, USA. djv4@psu.edu
Grant
Michael D
MD
Severns
Virginia
V
D001483:Base Sequence; D030561:Databases, Nucleic Acid; D006147:Guanine / Q000031:analogs & derivatives* / Q000096:biosynthesis*; D006801:Humans; D007438:Introns / Q000235:genetics*; D008969:Molecular Sequence Data; D010430:Pentosyltransferases / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000235:genetics; D050637:Receptors, Dopamine D3; D017421:Sequence Analysis; D020080:Tandem Repeat Sequences / Q000235:genetics*
C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D006147:Guanine; C019549:queuine; D010430:Pentosyltransferases; C020837:queuine tRNA-ribosyltransferase