title: Treatment of bifurcation coronary lesions: a review of current techniques and outcome.
abstract: Percutaneous treatment of coronary bifurcation lesions, pose a number of technical challenges to the interventional cardiologist. Each lesion has to be approached with its own, targeted solution in the context of the clinical picture, anatomy, and pathology. To achieve acceptable clinical outcomes a number of established techniques are available. The exact anatomy of the lesion determines the technique used. The most common approach is to stent the main vessel across the ostium of the side branch. The side branch can be additionally treated with a second stent or balloon angioplasty depending on the severity of the ostial lesion and/or evidence of active ischemia. Other techniques involve stenting the main branch up to the carina but sparing the side branches, multiple 'kissing stent' approaches ('Y','T', and 'V') or the 'culottes' technique. Follow-up data demonstrates a high (over 90%) technical success rate. Clinical outcome is variable but with conventional stents restenosis rates higher than 30% have been reported in most studies and there is no added advantage in routine stenting of both main vessel and side branch. Recent introduction of drug-eluting stents has resulted in a lower event rate and reduction of main vessel restenosis in comparison with historical controls. Side branch ostial restenosis remains a problem, which may require the development of novel 'bifurcate' stent designs to allow complete coverage with a single stent.
authors: Narbeh
authors: N
authors: Melikian
authors: Carlo
authors: C
authors: Di Mario
mesh_terms: D000800:Angioplasty, Balloon / Q000379:methods; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use; D003324:Coronary Artery Disease / Q000150:complications / Q000628:therapy*; D023921:Coronary Stenosis / Q000209:etiology / Q000517:prevention & control*; D004337:Drug Carriers; D006801:Humans; D020123:Sirolimus / Q000008:administration & dosage; D015607:Stents; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D020123:Sirolimus