Antibacterial properties of nitric oxide-releasing sol-gels.
The antibacterial characteristics of nitric oxide (NO)-releasing sol-gel coatings are described. The NO release from these surfaces is steady over short periods (approximately 1 h) and measurable over several days. The ability of NO to prevent bacterial adhesion is evaluated by exposing controls and NO-releasing sol-gels to approximately 10(8) colony-forming units (cfu)/mL saline suspensions of Pseudomonas aeruginosa. Pseudomonas aeruginosa adhesion to sol-gel controls varies depending on the sol-gel formulation. Sol-gel surfaces capable of NO release decrease bacterial adhesion by 30% to 95% relative to controls. The contact angle measurements of control and NO-releasing surfaces are similar, supporting NO's action as an antibacterial agent against bacterial adhesion.
Nablo
Brian J
BJ
Department of Chemistry, CB#3290, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
Schoenfisch
Mark H
MH
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001391:Azo Compounds / Q000378:metabolism; D001422:Bacterial Adhesion / Q000187:drug effects*; D002470:Cell Survival; D005782:Gels / Q000737:chemistry*; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000378:metabolism; D017655:Silicon Compounds / Q000737:chemistry / Q000378:metabolism; D013499:Surface Properties; D014867:Water
D000900:Anti-Bacterial Agents; D001391:Azo Compounds; D005782:Gels; D017655:Silicon Compounds; C452539:diazeniumdiolate; D014867:Water; D009569:Nitric Oxide