The spindle assembly and spindle position checkpoints.
The mitotic spindle segregates chromosomes to opposite ends of the cell in preparation for cell division. Chromosome attachment to the spindle is monitored by the spindle assembly checkpoint, and at least in yeast cells, penetration of one spindle pole into the bud is monitored by the spindle position checkpoint. We review the historical origins of these checkpoints and recent progress in understanding their surveillance pathways. We also highlight fascinating but as yet unresolved questions, and examine crosstalk between the checkpoints.
Lew
Daniel J
DJ
Department of Pharmacology and Cancer Biology, Box 3813, Duke University Medical Center, Durham, North Carolina 27710, USA. daniel.lew@duke.edu
Burke
Daniel J
DJ
D002455:Cell Division / Q000502:physiology*; D018816:Genes, cdc / Q000502:physiology; D018386:Kinetochores / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000502:physiology; D008941:Spindle Apparatus / Q000502:physiology*