title: Effect of antioxidant probucol on cell-mediated LDL oxidation in vitro and in vivo.
abstract: We studied the effect of phenol antioxidant probucol on free radical oxidation of LDL isolated from blood plasma of healthy donors. Oxidation was induced by co-incubation of LDL with cultured peripheral blood monocyte-macrophages and human umbilical vein endothelial cells under conditions of ischemia-reperfusion. In addition, the effect of probucol therapy on oxidability of plasma LDL in CHD patients was examined. Probucol (0.1-10 microM) efficiently protected LDL from free radical oxidation in vitro and in vivo.
authors: V. N. Orekhovich State Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, Moscow.
authors: M V
authors: MV
authors: Bilenko
authors: A V
authors: AV
authors: Khil'chenko
authors: G G
authors: GG
authors: Konovalova
authors: V Z
authors: VZ
authors: Lankin
mesh_terms: D000924:Anticholesteremic Agents / Q000378:metabolism; D000975:Antioxidants / Q000378:metabolism*; D002478:Cells, Cultured; D003327:Coronary Disease / Q000188:drug therapy; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D008077:Lipoproteins, LDL / Q000737:chemistry / Q000378:metabolism*; D010084:Oxidation-Reduction; D011341:Probucol / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D000924:Anticholesteremic Agents; D000975:Antioxidants; D008077:Lipoproteins, LDL; D011341:Probucol