title: Quaternary ammonium 3-(aminoethoxy)pyridines as antinociceptive agents.
abstract: Quaternization via N-methylation of the terminal amines of a series of 3-(dialkylaminoethoxy)pyridines resulted in analogues that displayed up to 50-60-fold enhanced affinity for nicotinic acetylcholinergic (nACh) receptors. Several of these compounds displayed antinociceptive properties in mice using the tail-flick assay and serve as possible leads for the development of novel analgesic agents.
authors: Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond 23298, USA.
authors: Rahime
authors: R
authors: Simsek
authors: Jean
authors: J
authors: Chang-Fong
authors: Mase
authors: M
authors: Lee
authors: Malgorzata
authors: M
authors: Dukat
authors: M
authors: M
authors: Imad Damaj
authors: Billy R
authors: BR
authors: Martin
authors: Richard A
authors: RA
authors: Glennon
mesh_terms: D000700:Analgesics / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D011725:Pyridines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D011869:Radioligand Assay; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000378:metabolism
chemical_list: D000700:Analgesics; D011725:Pyridines; D000644:Quaternary Ammonium Compounds; D011978:Receptors, Nicotinic