title: Patients with extraintestinal manifestations have a higher risk of developing pouchitis in ulcerative colitis: multivariate analysis.
abstract: BACKGROUND
  Restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA) have been the surgical treatments of choice for ulcerative colitis (UC). However, the IPAA is sometimes complicated with pouchitis. Furthermore, the cumulative risk and risk factors for developing pouchitis in patients with UC undergoing IPAA have not been reported in any Asian population. The aim of our study is to clarify the cumulative risk and risk factors for developing pouchitis in Japanese patients with UC undergoing IPAA.
  
  
  METHODS
  Fifty-eight patients with UC undergoing IPAA were retrospectively evaluated for the presence of pouchitis, gender, age of onset, history of smoking, presence of extraintestinal manifestations (EIMs) and type of operation. The diagnosis of pouchitis was based on the pouchitis disease activity index. The cumulative risk and risk factors for developing pouchitis were assessed.
  
  
  RESULTS
  The cumulative risks for developing pouchitis at 1 and 5 years were 9.0% and 14.4%, respectively. The estimated risks of pouchitis at 5 years was 48.1% in patients with EIMs and 4.6% in those without. Both univariate and multivariate analyses revealed that the presence of EIMs is a significant risk factor (hazard ratio 16.85, 95% confidence interval 3.12-91.00; P=0.001).
  
  
  CONCLUSIONS
  The presence of EIMs is a significant risk factor for the development of pouchitis in Japanese patients with UC undergoing IPAA.
authors: Dept. of Surgical Oncology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan. HATAK-SUR@h.u-tokyo.ac.jp
authors: K
authors: K
authors: Hata
authors: T
authors: T
authors: Watanabe
authors: M
authors: M
authors: Shinozaki
authors: H
authors: H
authors: Nagawa
mesh_terms: D003093:Colitis, Ulcerative / Q000150:complications* / Q000601:surgery; D039021:Colonic Pouches / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D011183:Postoperative Complications; D019449:Pouchitis / Q000209:etiology*; D012307:Risk Factors