Possible prediction of the efficiency of chemotherapy in patients with lymphoproliferative diseases based on MDR1 gene G2677T and C3435T polymorphisms.
Study of polymorphism in MDR1 gene exons 21 and 26 revealed that T2677T and T3435T alleles are not a factor predisposing to lymphoproliferative diseases, but they determine the efficiency chemotherapy. Individuals with T2677T and T3435T haplotypes are at highest risk of drug resistance. Association between genotypes G2677T and C3435T was detected in normal subjects and in patients with lymphoproliferative diseases.
Goreva
O B
OB
Institute of Molecular Biology and biophysics, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. gob@ngs.ru
Grishanova
A Yu
AY
Mukhin
O V
OV
Domnikova
N P
NP
Lyakhovich
V V
VV
D000483:Alleles; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D019450:Genes, MDR; D005838:Genotype; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy* / Q000235:genetics; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy* / Q000235:genetics; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests
D000970:Antineoplastic Agents