[Cutaneous adverse drug reaction with pulmonary involvement].
BACKGROUND
Cutaneous adverse drug reactions can be life-threatening: toxic necrolis and hypersensitivity syndrome or DRESS ("Drug Rash with Eosinophilia and Systemic Symptoms").


BACKGROUND
Pulmonary involvement is considered as a severity factor. During toxic epidermal necrolysis, pulmonary involvement is present in about 25% of cases; it corresponds to the detachment and the necrosis of bronchial epithelium. Specific bronchial involvement is of poor prognosis. During DRESS, pulmonary involvement is rare corresponding to an interstitial pneumonia with eosinophils.


CONCLUSIONS
Progress in the knowledge of pathophysiology will help to target therapeutics.


CONCLUSIONS
Early recognition of pulmonary complications must lead to adapt treatment and to improve prognosis.
Wolkenstein
P
P
Service de Dermatologie, Hôpital Henri-Mondor, Créteil, France. pierre.wolkenstein@hmn.ap-hop-paris.fr
Chosidow
O
O
D003937:Diagnosis, Differential; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced*; D017563:Lung Diseases, Interstitial / Q000139:chemically induced; D009336:Necrosis; D011379:Prognosis; D011657:Pulmonary Eosinophilia / Q000139:chemically induced; D012720:Severity of Illness Index; D013262:Stevens-Johnson Syndrome / Q000473:pathology*; D013577:Syndrome