title: Preoperative antimicrobial administration for prevention of postoperative infection in patients with laparoscopic cholecystectomy.
abstract: The present study was designed to investigate whether the administration of antimicrobial agents before laparoscopic cholecystectomy (LC) is more effective for prevention of postoperative infection. During the period from January 1991 to September 2001, 397 patients treated with sulbactam/cefoperazone (SBT/CPZ) for prevention of postoperative infection were studied: 200 patients received SBT/CPZ 1 hr before LC, and 197 patients were not given the preoperative treatment. The positive rate of bacteria in the gallbladder bile in the group receiving preoperative SBT/CPZ was 12.0%, a significant suppression compared with 19.8% in the group without preoperative treatment (P < 0.05). Identification of microorganisms in the bile revealed E. coli and Klebsiella in the preoperative treatment group, which showed a significant suppression (P < 0.05). The mean white blood cell count was significantly lower in the preoperative treatment group (9860/microl) than in the nonpreoperative treatment group (10,520/microl) (P < 0.05). The above results demonstrate that administration of SBT/CPZ before LC suppressed the level of bacteria in the bile, resulting in a significant reduction in complications induced by postoperative infection.
authors: Second Department of Surgery, Wakayama Medical University, School of Medicine, 811-1 Kimiidera, Wakayama 641-8510, Japan.
authors: Kazuhisa
authors: K
authors: Uchiyama
authors: Manabu
authors: M
authors: Kawai
authors: Hironobu
authors: H
authors: Onishi
authors: Masaji
authors: M
authors: Tani
authors: Hiroyuki
authors: H
authors: Kinoshita
authors: Masaki
authors: M
authors: Ueno
authors: Hiroki
authors: H
authors: Yamaue
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D001419:Bacteria / Q000302:isolation & purification; D001646:Bile / Q000382:microbiology; D002438:Cefoperazone / Q000627:therapeutic use*; D017081:Cholecystectomy, Laparoscopic; D005260:Female; D005704:Gallbladder / Q000378:metabolism; D006801:Humans; D017053:Infection Control; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011300:Preoperative Care; D013407:Sulbactam / Q000627:therapeutic use*; D013530:Surgical Wound Infection / Q000517:prevention & control
chemical_list: D000900:Anti-Bacterial Agents; D002438:Cefoperazone; D013407:Sulbactam