Hypersensitivity to progesterone-in-oil after in vitro fertilization and embryo transfer.
OBJECTIVE
To report the occurrence and management of pulmonary compromise, marked leukocytosis, and eosinophilia in a patient receiving P-in-oil after IVF and embryo transfer.


METHODS
Case report.A tertiary referral reproductive medicine unit.


METHODS
A 29-year-old patient receiving P-in-oil supplementation after IVF embryo transfer.


METHODS
Extensive diagnostic testing and surveillance for hypersensitivity to P in sesame oil; development of an alternative oil-based P-in-oil suspension.


METHODS
Tolerance of alternative P vehicle; clinical pregnancy.


RESULTS
The patient tolerated an alternative P oil vehicle and successfully achieved a clinical pregnancy after frozen embryo transfer.


CONCLUSIONS
Although rare, hypersensitivity reactions may occur in patients receiving P-in-oil supplementation after IVF embryo transfer. Testing for tolerance and subsequent use of alternative P vehicles may be an effective strategy in managing patients with sensitivity to P-in-oil.
Phy
Jennifer L
JL
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA. phy.jenniferlynn@mayo.edu
Weiss
William T
WT
Weiler
Catherine R
CR
Damario
Mark A
MA
D000328:Adult; D004342:Drug Hypersensitivity / Q000150:complications / Q000209:etiology*; D004624:Embryo Transfer; D004802:Eosinophilia / Q000209:etiology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007964:Leukocytosis / Q000209:etiology; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology; D014677:Pharmaceutical Vehicles / Q000009:adverse effects*; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage*; D013902:Radiography, Thoracic; D012715:Sesame Oil / Q000009:adverse effects*
D014677:Pharmaceutical Vehicles; D011374:Progesterone; D012715:Sesame Oil