title: Simian virus 40 sequences in malignant lymphomas in Japan.
abstract: Recent studies showed that SV40 is detected in >40% of non-Hodgkin's lymphoma (NHL) in United States, suggesting SV40-contaminated poliovaccines widely used during the period 1955-1963 to be a major source of SV40 in NHL. We examined the presence of SV40 sequences in 122 cases with NHL and 3 with Hodgkin's lymphoma from Japan. The detection rate of SV40 sequences in diffuse large B-cell lymphoma (19%) was higher than that in peripheral blood cells of normal healthy volunteers in Japan (4.7%; P < 0.05) reported previously as controls for comparison with the study results from cancer patients, suggesting a role for SV40 in the development of diffuse large B-cell lymphoma. In contrast, the frequency of SV40 sequences in NHL cases born between 1951 and 1963 (12%), during which SV40-contaminated poliovaccines might have been inoculated, is not significantly different from that in cases born before 1950 (11%) or after 1964 (15%). SV40 is a new candidate etiologic factor for malignant lymphoma not only in the United States but also in Japan.
authors: Department of Pathology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors: Shin-ichi
authors: S
authors: Nakatsuka
authors: Angen
authors: A
authors: Liu
authors: Zhiming
authors: Z
authors: Dong
authors: Shintaro
authors: S
authors: Nomura
authors: Tetsuya
authors: T
authors: Takakuwa
authors: Hajime
authors: H
authors: Miyazato
authors: Katsuyuki
authors: K
authors: Aozasa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000952:Antigens, Polyomavirus Transforming / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D007223:Infant; D007564:Japan; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000821:virology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000235:genetics / Q000821:virology; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000821:virology*; D016399:Lymphoma, T-Cell / Q000235:genetics / Q000821:virology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D013539:Simian virus 40 / Q000235:genetics*
chemical_list: D000952:Antigens, Polyomavirus Transforming