[The use of liposomes as intravitreal drug delivery system].
Liposomes are vesicular lipidic systems allowing encapsulation of drugs. This article reviews the relevant issues in liposome structure (composition and size), and their influence on intravitreal pharmacokinetics. Liposome-mediated drug delivery to the posterior segment of the eye via intravitreal administration has been addressed by several authors and remains experimental. Liposomes have been used for intravitreal delivery of antibiotics, antivirals, antifungal drugs, antimetabolites, and cyclosporin. Encapsulation of these drugs within liposomes markedly increased their intravitreal half-life, and reduced their retinal toxicity. Liposomes have also shown an attractive potential for retinal gene transfer by intravitreal delivery of plasmids or oligonucleotides.
Bejjani
R A
RA
Développement, Vieillissement et Pathologie de la Rétine, INSERM U450, UFR Broussais/Hôtel-Dieu, Institut Biomédical des Cordeliers, 15, rue de l'Ecole de Médecine, 75270 Paris 06.
Jeanny
J-C
JC
Bochot
A
A
Behar-Cohen
F
F
D000287:Administration, Topical; D001682:Biological Availability; D001813:Blood-Retinal Barrier; D016503:Drug Delivery Systems / Q000379:methods; D018014:Gene Transfer Techniques; D006207:Half-Life; D006801:Humans; D008081:Liposomes / Q000008:administration & dosage* / Q000737:chemistry; D008657:Metabolic Clearance Rate; D014822:Vitreous Body / Q000187:drug effects* / Q000378:metabolism
D008081:Liposomes