The use of HSP70 for prevention of consequences of unavoidable stress in rats.
We studied whether intranasal treatment with HSP70 can be used for the correction of maladaptive behavior in rats after unavoidable stress. After 3 intranasal injection of HSP70 in a dose of 3.25 microg we observed normalization of adaptive behavior after unavoidable stress and improvement of physiological reserves of the organism.
Flerov
M A
MA
I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg. sts@infran.ru
Ordyan
N E
NE
Margulis
B A
BA
Guzhova
I V
IV
V'yushina
A V
AV
Pivina
S G
SG
Gerasimova
I A
IA
D000281:Administration, Intranasal; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D004558:Electric Stimulation; D018840:HSP70 Heat-Shock Proteins / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D006380:Helplessness, Learned; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000188:drug therapy*
D018840:HSP70 Heat-Shock Proteins