Distigmine bromide induced acute psychotic disorder in a patient with multiple sclerosis.
A female patient with multiple sclerosis (MS) suffered from an acute psychotic disorder after taking distigmine bromide for detrusor dysfunction. She showed a dramatic relief of her symptoms after the medication, distigmine bromide, was stopped. Distigmine is not supposed to penetrate the blood-brain barrier (BBB). However, in MS patients a leakage of the BBB could be hypothesized.
Himmerich
Hubertus
H
Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany. himmerich@mpipsykl.mpg.de
Szegedi
Armin
A
Klawe
Christoph
C
Anghelescu
Ion
I
Müller
Matthias J
MJ
D005260:Female; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy*; D010277:Parasympathomimetics / Q000008:administration & dosage* / Q000627:therapeutic use; D011569:Psychiatric Status Rating Scales; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D011726:Pyridinium Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D013406:Suicide, Attempted / Q000523:psychology; D016055:Urinary Retention / Q000188:drug therapy*
D010277:Parasympathomimetics; D011726:Pyridinium Compounds; C084645:distigmine