title: [Clinical significance of bone marrow micrometastases of breast tumors].
abstract: Detection of hematogenous micrometastases (MM) in bone marrow might play important role in determining stage, prognosis and multimodality treatment strategy of invasive breast cancer. Therefore we studied the presence of occult tumor cells in bone marrow of outpatients operated on with breast cancer by detecting cytokeratin 20 mRNA using the RT-PCR method. In 182 primary breast cancer patients 54 (29.7%) micrometastases were detected while in 128 patients (70.3%) no tumor cells were found in the bone marrow aspirates. Correlation of MM with HER-2, c-met, nm23, p53 and estrogen receptor (ER) were studied. The presence of MM was correlated with HER-2, nm23- and p53 positivity and with low frequency of nm23 and ER. The possible role of bone marrow MM in selecting node negative breast cancer patients for adjuvant therapy should be tested in randomized prospective clinical trials.
authors: Altalános- és Mellkassebészeti Osztály, Országos Onkológiai Intézet, Budapest. dub@oncol.hu
authors: Sándor
authors: S
authors: Dubecz
authors: Orsolya
authors: O
authors: Csuka
authors: Klára
authors: K
authors: Török
authors: Norbert
authors: N
authors: Vasas
authors: Gábor
authors: G
authors: Péley
authors: Zoltán
authors: Z
authors: Doleschal
authors: Zoltán
authors: Z
authors: Sulyok
authors: István
authors: I
authors: Láng
authors: István
authors: I
authors: Köves
mesh_terms: D000328:Adult; D000368:Aged; D001365:Axilla; D014408:Biomarkers, Tumor / Q000032:analysis*; D019046:Bone Marrow Neoplasms / Q000737:chemistry* / Q000556:secondary* / Q000628:therapy; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007381:Intermediate Filament Proteins / Q000032:analysis* / Q000235:genetics; D053554:Keratin-20; D008207:Lymphatic Metastasis; D008875:Middle Aged; D054778:NM23 Nucleoside Diphosphate Kinases; D009367:Neoplasm Staging; D009701:Nucleoside-Diphosphate Kinase; D011237:Predictive Value of Tests; D011379:Prognosis; D011506:Proteins / Q000032:analysis; D019859:Proto-Oncogene Proteins c-met / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D007381:Intermediate Filament Proteins; D053554:Keratin-20; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase; D011506:Proteins; D019859:Proto-Oncogene Proteins c-met; D012333:RNA, Messenger; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D016159:Tumor Suppressor Protein p53; C507499:KRT20 protein, human; C517938:NME1 protein, human