[G894T mutation of the endothelial nitric oxide synthase gene in Chinese Han nationality].
To investigate the distribution of G894T mutation of the endothelial nitric oxide synthase (eNOS) gene in Chinese Han nationality.



G894T mutation of the eNOS gene of 108 unrelated healthy individuals was studied by means of polymerase chain reaction/restriction fragment length polymorphism (PCR-RFLP) analysis.



All subjects were genotyped for eNOS gene; the frequencies of the GG, GT and TT genotypes were 0.9095, 0.0883 and 0.0021, respectively. In the Han nationality, the frequency of the GT, TT genotypes was lower than that in Japanese and Caucasian of UK (P< 0.05).



These results suggest that there are significant differences in G894T mutation of eNOS gene between the Chinese Han nationality and other ethnic populations.
Wei
Dan-hong
DH
The Second Affilliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
Li
Wei
W
Hu
Ying-hong
YH
Chen
Zhi-mei
ZM
Shan
Jiang
J
D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005838:Genotype; D006801:Humans; D009154:Mutation; D019001:Nitric Oxide Synthase / Q000235:genetics*; D052250:Nitric Oxide Synthase Type III; D016133:Polymerase Chain Reaction
C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III