Bone graft alternatives for spinal fusion.
Bone grafting to achieve fusion is frequently performed in spinal surgery. Autograft is the gold standard bone graft material. However, due to limitations of supply and morbidity associated with the harvest of autograft, alternatives are being considered. Osteoconductive matrices, such as allograft, calcium or ceramic preparations are one such class of potential bone graft alternatives, but generally they lack osteoinductive properties. Recent attention has focused on osteoinductive materials such as demineralised bone matrix, recombinant bone morphogenetic proteins and bone marrow aspirates or blood product concentrates. These products may be combined with osteoconductive carriers and are clearly finding a place in the clinical arena.
Grauer
Jonathan N
JN
Rothman Institute at Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Beiner
John M
JM
Kwon
Brian K
BK
Vaccaro
Alexander R
AR
D000818:Animals; D016026:Bone Marrow Transplantation; D001857:Bone Matrix / Q000737:chemistry / Q000637:transplantation*; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use*; D016025:Bone Transplantation; D006801:Humans; D011994:Recombinant Proteins / Q000627:therapeutic use; D013123:Spinal Fusion / Q000379:methods*
D019485:Bone Morphogenetic Proteins; D011994:Recombinant Proteins