title: Facile N-derivatization of alpha-amino esters and amides via benzotriazolylmethyl derivatives.
abstract: Alpha-(N-substituted amino)esters were prepared in a two-step procedure from available unsubstituted alpha-amino esters. alpha-Amino esters are first converted into the corresponding N-benzotriazolylmethyl derivatives; in the second step, the benzotriazole group is substituted by various nucleophiles with or without the presence of a Lewis acid to give substituted alpha-amino esters in high overall yield under mild conditions with no signs of racemization. Boc-protected amino acids were converted into alpha-amino amides; subsequent deprotection allowed the conversion into N-substituted derivatives analogously to the alpha-amino esters, without racemization in high yields under mild conditions.
authors: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
authors: Alan R
authors: AR
authors: Katritzky
authors: Nataliya
authors: N
authors: Kirichenko
authors: Boris V
authors: BV
authors: Rogovoy
authors: Hai-Ying
authors: HY
authors: He