Recurrent pneumococcal meningitis in a splenectomised HIV-infected patient.
BACKGROUND
Streptococcus pneumoniae is a major cause of human disease, especially in pre-school children and elderly people, as well as in special risk groups such as asplenic, antibody deficient patients, or presenting disruption of natural barriers. The occurrence of pneumococcal disease has increased with the onset of the HIV epidemic and the emergence of drug-resistance.


METHODS
We report the case of an HIV-1-infected patient who experienced three episodes of recurrent pneumococcal meningitis over a 4-year period, despite chemoprophylaxis and capsular vaccination.


CONCLUSIONS
Efficacy of anti-pneumococcal chemoprophylaxis and vaccination in HIV-infected patients are discussed in the light of this particular case.
Morand
Philippe C
PC
Laboratoire de Microbiologie; Hôpital Necker-Enfants Malades, 149 rue de Sèvres 75743 Paris Cedex 15, France. morand@mpiib-berlin.mpg.de
Veuillez
Veronique
V
Poyart
Claire
C
Abachin
Eric
E
Quesne
Gilles
G
Dupont
Bertrand
B
Berche
Patrick
P
Viard
Jean-Paul
JP