Solid-phase total synthesis of scytalidamide A.
The first total synthesis of the natural cyclic heptapeptide scytalidamide A was achieved on solid phase using two different resins, a phenylalanine silane resin and a 4-methoxybenzaldehyde backbone linker resin. The synthetic product confirms the structure of the natural product reported in the preceding paper in this issue (Tan, L. T.; Cheng, X. C.; Jensen, P. R.; Fenical, W. J. Org. Chem. 2003, 68, 8767).
Gu
Wenxin
W
Department of Chemistry and Drug Discovery Program, Northwestern University, Evanston, IL 60208-3113, USA.
Silverman
Richard B
RB
D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry
D010456:Peptides, Cyclic; C482958:Scytalidamide A