Antiosteoporotic effect of ethanol extract of Cissus quadrangularis Linn. on ovariectomized rat.
Ethanol extract of Cissus quadrangularis was evaluated for its anti-osteoporotic activity in ovariectomized rat model of osteoporosis at two different dose levels of 500 and 750 mg/kg per day. Healthy female albino rats were divided into five groups of six animals each. First group was sham operated and served as control. All the remaining groups were ovariectomized. Group 2 was fed with equivolume of saline and served as ovariectomized control. Groups 3-5 were orally treated with Raloxifen (5.4 mg/kg) and ethanol extract of Cissus quadrangularis (500 and 750 mg/kg), respectively. The findings assessed on the basis of biomechanical, biochemical and histopathological parameters showed that the ethanol extract of the plant had a definite antiosteoporotic effect.
Shirwaikar
Annie
A
Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal, India. annie.shirwaikar@cops.manipal.edu
Khan
Saleemulla
S
Malini
S
S
D000818:Animals; D032422:Cissus / Q000737:chemistry*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D005260:Female; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control; D010052:Ovariectomy; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D018514:Plant Structures / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D023382:Toxicity Tests, Acute
D010936:Plant Extracts; D000431:Ethanol