Synthesis of benzylamides of dipeptides as potential inhibitors of plasmin.
Four benzylamides of dipeptides with the general formula: X-L-Lys-NH-CH2-C6H5, where X = L-or D-Leu and L-or D-Phe were prepared as potential inhibitors of plasmin. All of them influenced on the fibrynolytic activity of plasmin, but only D-Leu-L-Lys-NH-CH2-C6H5 inhibited the amidolytic activity of this enzyme. None of the tested compounds was an inhibitor of thrombin in an amidolytic test.
Midura-Nowaczek
K
K
Department of Organic Chemistry, Medical University of Białystok, Poland.
Roszkowska-Jakimiec
W
W
Lepietuszko
I
I
Bruzgo
I
I
D001593:Benzyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D004151:Dipeptides / Q000138:chemical synthesis*; D005341:Fibrinolysin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005343:Fibrinolytic Agents / Q000494:pharmacology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013917:Thrombin / Q000037:antagonists & inhibitors
D001593:Benzyl Compounds; D004151:Dipeptides; D005343:Fibrinolytic Agents; D007202:Indicators and Reagents; D013917:Thrombin; D005341:Fibrinolysin