title: Fatal hydrops fetalis caused by anti-D in a mother with partial D.
abstract: BACKGROUND
  Rare cases of hemolytic disease of the newborn occur in women with genetic variants of the D antigen. A partial D variant might be suspected when typing for the D antigen shows weaker-than-normal reactions (weak D). Historically, patients with a weak D phenotype have not been considered candidates for Rh immune globulin prophylaxis.
  
  
  METHODS
  A gravida 2, para 1 woman with A-positive blood type, delivered an infant who died from severe hemolytic disease of the newborn 6 days after birth. Anti-D, undetectable at the first prenatal visit, was identified (titer 1:64) at delivery. The mother's red cells were partial D(VI) phenotype.
  
  
  CONCLUSIONS
  Although severe hemolytic disease in patients with partial D is rare, this neonatal death illustrates the need for a change in management of women with weak D.
authors: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Geisinger Medical Center, Danville, Pennsylvania 17821, USA.
authors: Michael
authors: M
authors: Cannon
authors: Richard
authors: R
authors: Pierce
authors: Evan Beth
authors: EB
authors: Taber
authors: Jodi
authors: J
authors: Schucker
mesh_terms: D000328:Adult; D004899:Erythroblastosis, Fetal / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015160:Hydrops Fetalis / Q000209:etiology*; D007518:Isoantibodies / Q000276:immunology*; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System / Q000276:immunology*
chemical_list: D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System