title: [Modalities and limits of conservative treatment of adenocarcinoma in situ of the uterine cervix: analysis of nine cases and review of the literature].
abstract: OBJECTIVE
  The aim of this study is to assess the results of conservative management of adenocarcinoma in situ (AIS) of the uterine cervix in young patients.
  
  
  METHODS
  Data of 16 patients treated for AIS were reviewed: 10 were treated initially conservatively (cold knife conization in five patients, loop excision in three patients and cervical amputation in two patients) and six radically. One patient treated initially conservatively with loop excision and positive margins underwent a completion surgery (hysterectomy).
  
  
  RESULTS
  None patient had recurrence whatever the type of surgery (radical or conservative) with a mean follow-up of 74 months. Two pregnancies were observed.
  
  
  CONCLUSIONS
  Conservative surgery for patients with AIS could be considered in young patients. But [for] reviewing literature several conditions should be respected: careful follow-up after conservative treatment; cold knife conization; length of cone specimen >25 mm and free margins. If those criteria are respected the risk of recurrent disease under the form of invasive carcinoma is low.
authors: Service de chirurgie oncologique gynécologique, institut Gustave-Roussy, 39, rue Camille-Desmoulins, 94805 Villejuif, France. morice@igr.fr
authors: S
authors: S
authors: Omnes
authors: P
authors: P
authors: Morice
authors: S
authors: S
authors: Camatte
authors: R
authors: R
authors: Rouzier
authors: P
authors: P
authors: Pautier
authors: C
authors: C
authors: Pomel
authors: C
authors: C
authors: Lhommé
authors: C
authors: C
authors: Haie-Meder
authors: P
authors: P
authors: Duvillard
authors: D
authors: D
authors: Castaigne
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery*; D019092:Conization; D005260:Female; D006801:Humans; D007044:Hysterectomy; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D012189:Retrospective Studies; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*