A substructure approach toward polymeric receptors targeting dihydrofolate reductase inhibitors. 2. Molecularly imprinted polymers against Z-l-glutamic acid showing affinity for larger molecules.
The preparation of a molecularly imprinted polymer against N-Z-L-glutamic acid using a novel bis-urea functional monomer is described. The polymer exhibits affinity for the template over N-Z-protected aspartic acid and glycine and, further, is capable of binding larger molecules, e.g., the anti-cancer drug methotrexate, containing the glutamate substructure.
Hall
Andrew J
AJ
Institut für Anorganische Chemie und Analytische Chemie, Johannes Gutenberg Universität, Duesbergweg 10-14, D-55099, Mainz, Germany. andy@infu.uni-dortmund.de
Achilli
Laura
L
Manesiotis
Panagiotis
P
Quaglia
Milena
M
De Lorenzi
Ersilia
E
Sellergren
Börje
B
D004791:Enzyme Inhibitors / Q000737:chemistry*; D005493:Folic Acid Antagonists / Q000737:chemistry* / Q000494:pharmacology; D018698:Glutamic Acid / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008727:Methotrexate / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry*; D013762:Tetrahydrofolate Dehydrogenase / Q000187:drug effects*
D004791:Enzyme Inhibitors; D005493:Folic Acid Antagonists; D011108:Polymers; D018698:Glutamic Acid; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate