Phagocytosis by neutrophils.
Phagocytosis is central to the microbicidal function of neutrophils. Pathogens are initially engulfed into a plasma membrane-derived vacuole, the phagosome, which proceeds to acquire degradative properties by a complex process termed maturation. In this chapter, we discuss the current knowledge of the molecular mechanisms underlying phagosome formation and maturation in neutrophils.
Lee
Warren L
WL
Cell Biology Program, Hospital for Sick Children and Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5G 1X8.
Harrison
Rene E
RE
Grinstein
Sergio
S
D000818:Animals; D006801:Humans; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis / Q000235:genetics / Q000502:physiology; D010588:Phagosomes / Q000502:physiology; D015398:Signal Transduction