title: Lipocalin-type prostaglandin D synthase (beta-trace) in cerebrospinal fluid: a useful marker for the diagnosis of normal pressure hydrocephalus.
abstract: Lipocalin-type prostaglandin D synthase (PGDS) is considered to be mainly produced in the leptomeninges and secreted into cerebrospinal fluid (CSF). We found PGDS levels in CSF of patients with normal pressure hydrocephalus (NPH) (8.99+/-2.59 microg/ml, mean+/-S.D., n=14) to be significantly lower than levels in a control (15.29+/-5.17, n=14, P<0.0001) and other dementia group (19.14+/-4.34, n=7, P=0.0003). Thus, PGDS level in CSF is a useful marker for the differential diagnosis of NPH from other diseases with dementia.
authors: Department of Neurosurgery and Restorative Neuroscience, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8602, Japan. mitmase@med.nagoya-cu.ac.jp
authors: Mitsuhito
authors: M
authors: Mase
authors: Kazuo
authors: K
authors: Yamada
authors: Naoki
authors: N
authors: Shimazu
authors: Kosuke
authors: K
authors: Seiki
authors: Hiroshi
authors: H
authors: Oda
authors: Hiroya
authors: H
authors: Nakau
authors: Takashi
authors: T
authors: Inui
authors: Weidong
authors: W
authors: Li
authors: Naomi
authors: N
authors: Eguchi
authors: Yoshihiro
authors: Y
authors: Urade
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000134:cerebrospinal fluid; D003704:Dementia / Q000134:cerebrospinal fluid; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000134:cerebrospinal fluid*; D019746:Intramolecular Oxidoreductases / Q000134:cerebrospinal fluid*; D054834:Lipocalins; D008297:Male; D008875:Middle Aged
chemical_list: D015415:Biomarkers; D054834:Lipocalins; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase