Evaluation of neuropharmacological effects of Rumex maritimus Linn. (Polygonaceae) root extracts.
Hexane, ethyl acetate and methanol extracts of the root of Rumex maritimus Linn. (Polygonaceae) were evaluated for neuropharmacological activities in different models. All the extracts significantly and dose dependently inhibited acetic acid induced abdominal constrictions in mice. The hexane and methanol extract exhibited significant central analgesic activity in the radiant heat method. Only the methanol extract showed statistically significant mild to moderate central nervous system depressant activity assessed by hole cross, open field and hole board test in the mice model.
Islam
M S
MS
Department of Pharmacy, University of Dhaka, Dhaka, Bangladesh.
Rahman
M T
MT
Rouf
A S S
AS
Rahman
F
F
D019342:Acetic Acid; D000465:Algorithms; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D011930:Reaction Time / Q000187:drug effects; D031804:Rumex / Q000737:chemistry*
D000700:Analgesics; D002492:Central Nervous System Depressants; D010936:Plant Extracts; D019342:Acetic Acid