Role of aqueous medium in mechanisms underlying the influence of immunoactive peptides in ultralow doses.
The mechanism underlying the influence of peptides in ultralow doses is based on distant signal transduction from the ligand molecules to target cells by means of water solitons. Biological activity of synthetic immunoactive peptides in concentrations below 10(-18) M depends on their structural and conformational characteristics. The data on temperature dependencies of the near-infrared spectrum for solutions of these peptides are presented.
Grigor'ev
E I
EI
St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences. ibg@mail.wplus.ru
Khavinson
V Kh
VKh
Malinin
V V
VV
Grigor'ev
A E
AE
Kudryavtseva
T A
TA
D008024:Ligands; D008934:Mitogens / Q000378:metabolism; D008958:Models, Molecular; D010455:Peptides / Q000008:administration & dosage* / Q000276:immunology*; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000502:physiology*; D012996:Solutions / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
D008024:Ligands; D008934:Mitogens; D010455:Peptides; D012996:Solutions; D014867:Water