Selective amination of polyhalopyridines catalyzed by a palladium-xantphos complex.
[reaction: see text] Amination of 5-bromo-2-chloropyridine (1a) catalyzed by a palladium-Xantphos complex predominately gives 5-amino-2-chloropyridine product 3a in 96% isolated yield and excellent chemoselectivity (3a/4a = 97:3). Amination of 2,5-dibromopyridine (11) under the same conditions exclusively affords 2-amino-5-bromopyridine 4a.
Ji
Jianguo
J
Neuroscience Research, Global Pharmaceutical Research and Development, Department-R47W, AP9A-1, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA. jianguo.ji@abbott.com
Li
Tao
T
Bunnelle
William H
WH