Treatment of large facial Bowen's disease: case report.
Bowen's disease (BD; squamous cell carcinoma in situ) is a common, persistent condition that can be related to chronic sun damage, and consequently, is usually located around the head and neck area and lower limbs. Bowen's disease can be treated with a variety of methods, including surgery or laser therapy, but large lesions tend to scar postexcision and hence are difficult to treat surgically. Here we present the case of a 75-year-old woman with a 20-year history of facial BD unabated by treatment with a variety of topical agents and cryotherapy. Application of imiquimod 5% cream on alternate nights for 6 weeks resulted in total clearance with no recurrence observed after 8 months.
Kossard
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Skin & Cancer Foundation Australia, Darlinghurst, NSW, Australia. skossard@scfa.edu.au
D000287:Administration, Topical; D000368:Aged; D000634:Aminoquinolines / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001913:Bowen's Disease / Q000175:diagnosis / Q000188:drug therapy*; D002278:Carcinoma in Situ / Q000188:drug therapy*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D005153:Facial Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077271:Imiquimod; D009824:Ointments; D016896:Treatment Outcome
D000634:Aminoquinolines; D000970:Antineoplastic Agents; D009824:Ointments; D000077271:Imiquimod