title: Synthesis of a new stable conformationally constrained 2,7-anhydrosialic acid derivative.
abstract: A stereoseletive synthesis of 2,7-anhydrosialic acid derivative 18 was achieved from d-glucono-delta-lactone. A highly syn-selective addition of Grignard reagent to theN-benzylimine 8 served as a key step.
authors: State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenlin Road, Shanghai 200032, China.
authors: Ke-Gang
authors: KG
authors: Liu
authors: Hai-Bin
authors: HB
authors: Zhou
authors: Yu-Lin
authors: YL
authors: Wu
authors: Zhu-Jun
authors: ZJ
authors: Yao
mesh_terms: D005942:Gluconates / Q000737:chemistry; D007783:Lactones / Q000737:chemistry*; D008956:Models, Chemical; D008968:Molecular Conformation; D015394:Molecular Structure; D019158:N-Acetylneuraminic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D005942:Gluconates; D007783:Lactones; C106477:glucono-1,4-lactone; D019158:N-Acetylneuraminic Acid