Spinal cord MRI in clinically isolated optic neuritis.
METHODS
One hundred and fifteen patients with clinically isolated optic neuritis underwent magnetic resonance imaging (MRI) of the brain and spinal cord within 3 months of the onset of symptoms.


RESULTS
Eighty one (70%) patients had brain lesions and 31 (27%) had cord lesions. Cord lesions were seen in 12% with a normal brain MRI, 21% with between one and eight brain lesions, and 45% with nine or more brain lesions. When the new diagnostic criteria for MS were applied, MRI cord imaging used for evidence of dissemination in time and space allowed a diagnosis of MS in only one additional asymptomatic patient at 1 year, two additional asymptomatic patients at 3 years.


CONCLUSIONS
Using existing criteria, spinal cord imaging rarely contributes to the diagnosis in patients with clinically isolated optic neuritis.
Dalton
C M
CM
NMR Research Unit, Institute of Neurology, London, UK.
Brex
P A
PA
Miszkiel
K A
KA
Fernando
K
K
MacManus
D G
DG
Plant
G T
GT
Thompson
A J
AJ
Miller
D H
DH
D000293:Adolescent; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009902:Optic Neuritis / Q000175:diagnosis* / Q000473:pathology*; D012680:Sensitivity and Specificity; D013116:Spinal Cord / Q000473:pathology*