title: White matter hyperintensities in bipolar and unipolar patients with relatively mild-to-moderate illness severity.
abstract: BACKGROUND
  Increased rates of white matter hyperintense lesions have been reported in mood disorder patients. However, the potential effects of age and illness severity on reported findings are not fully established. We examined the rates of hyperintense lesions in adult, non-elderly bipolar and unipolar patients, with a relatively mild-to-moderate illness severity, and in matched healthy controls.
  
  
  METHODS
  We examined brain MRI images in 24 bipolar (19-56 years, mean+/-S.D.=34.2+/-9.9 years) and 17 unipolar patients (24-59 years, 42.8+/-9.2 years), and 38 healthy controls (21-59 years, 36.8+/-9.7 years). T2-weighted and proton-density axial MRI images were obtained at 1.5 Tesla. The lesions were rated by two independent raters, using a semi-quantitative rating scale.
  
  
  RESULTS
  There were no significant differences in the frequency of hyperintensities between bipolar or unipolar patients and healthy controls. Age was related to the presence of subcortical gray matter hyperintensities for the whole sample. Among the unipolar patients, length of illness and presence of mood disorder in a first-degree relative were related to deep and periventricular white matter lesions, respectively.
  
  
  CONCLUSIONS
  The methodology utilized for measurement of the white matter hyperintensities was semi-quantitative.
  
  
  CONCLUSIONS
  Increased rates of white matter hyperintensities do not appear to be present in a group of relatively young mood disorder patients, with relatively mild to moderate illness severity. These brain lesions may be more directly related to late-life and more severe cases of these illnesses.
authors: Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. soares@uthscsa.edu
authors: Roberto B
authors: RB
authors: Sassi
authors: Paolo
authors: P
authors: Brambilla
authors: Mark
authors: M
authors: Nicoletti
authors: Alan G
authors: AG
authors: Mallinger
authors: Ellen
authors: E
authors: Frank
authors: David J
authors: DJ
authors: Kupfer
authors: Matcheri S
authors: MS
authors: Keshavan
authors: Jair C
authors: JC
authors: Soares
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000473:pathology* / Q000523:psychology; D001921:Brain / Q000473:pathology*; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000473:pathology* / Q000523:psychology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index