[A report of two cases--two patients of the extremely advanced hepatocellular carcinoma have responded completely for a long time after a combination therapy consisting of arterial chemotherapy and injection of interferon-alpha].
The prognosis of advanced hepatocellular carcinoma (HCC) is extremely poor. Patient 1 was a 43-year-old male with major portal tumor thrombi. He received combination therapy consisting of continuous arterial infusion (MTX 30 mg/m2, day 1, CDDP/5-FU 6 mg/m2: 250 mg/m2, day 1-14) and subcutaneous injection of IFN-alpha (500 x 10(4) U, 3 times a week, 4 weeks). Patient 2 was a 66-year-old male with major hepatic venous tumor thrombi. He received combination therapy consisting of continuous arterial infusion (5-FU 6 mg/m2: 250 mg/m2, day 1-14) and subcutaneous injection of IFN-alpha (500 x 10(4) U, 3 times a week, 4 weeks). Decrease in tumor was observed in both patients markers and marked regression of tumor was observed in both patients. They are still in complete response. This combination therapy is an effective strategy for advanced HCC.
Iijima
Shohei
S
Dept. of Surgery, Gastrointestinal Research Center, Minoh City Hospital.
Kikkawa
Nobuaki
N
Kurokawa
Eiji
E
Yamamoto
Hitoshi
H
Kato
Takeshi
T
Tsujie
Masaki
M
Ohshima
Satoshi
S
Hayashi
Taro
T
Naoi
Yasuto
Y
Hatanaka
Toshihiro
T
Danno
Michiki
M
Sakon
Masato
M
Nagano
Hiroaki
H
Dono
Keizo
K
Nakamori
Shoji
S
Umeshita
Koji
K
Monden
Morito
M
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D007261:Infusions, Intra-Arterial; D007279:Injections, Subcutaneous; D016898:Interferon-alpha / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D011379:Prognosis; D012074:Remission Induction
D016898:Interferon-alpha; D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate