title: Screening of Plasmodium falciparum iron superoxide dismutase inhibitors and accuracy of the SOD-assays.
abstract: In vitro evaluation of a chemical library of synthetic compounds using two consecutive assays has led to the discovery of fifteen compounds which have the ability to inhibit recombinant Plasmodium falciparum iron superoxide dismutase (PfSOD), suggested as a highly selective target for design of antiparasitic drugs. A large number of compounds were in fact excluded, because they were found to significantly interfere with the components of the assays, thus outlining the drawbacks relative to the use of standard SOD-assays for the research of compounds targeting SODs. The best of the selected compounds showed significant antimalarial activities against two strains of P. falciparum, including a strain moderately resistant to chloroquine.
authors: UMR/CNRS 5068, Université Paul Sabatier, Toulouse, France.
authors: Laurent
authors: L
authors: Soulère
authors: Patrick
authors: P
authors: Delplace
authors: Elisabeth
authors: E
authors: Davioud-Charvet
authors: Sandrine
authors: S
authors: Py
authors: Christian
authors: C
authors: Sergheraert
authors: Jacques
authors: J
authors: Périé
authors: Isabelle
authors: I
authors: Ricard
authors: Pascal
authors: P
authors: Hoffmann
authors: Daniel
authors: D
authors: Dive
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D066298:In Vitro Techniques; D010963:Plasmodium falciparum / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D013482:Superoxide Dismutase