Current status of liver transplantation.
Liver transplantation is accepted therapy for acute or chronic liver failure. Survival after LT has improved significantly in developed countries and this has increased the awareness of this treatment modality in the developing world. Successful LT in both children and adults have now been reported from India. Chronic liver failure secondary to cholestatic liver disease in the most frequent indication for LT, with biliary with atresia as the single commonest cause. Innovative techniques such as reduced size, splint, and living donor liver transplantation are being applied more often to decrease long waiting times and reduce associated morbidity and mortality. Early postoperative complications include primary graft failure, venous thrombosis, rejection, biliary complications and infections. Late complication includes CMV or EBV infections, side effects of immunosuppression, post transplantation lymphoproliferative disease and late biliary strictures. Most children achieve good quality of life. There are still many lessons to learn and there are future challenges such as the ever increasing problems of donor scarcity and the search for potent but less toxic immunosuppressive agents.
Kelly
Deirdre
D
The Liver Unit, Birmingham Children's Hospital, Steelhouse Lane, Birmingham.
Sibal
Anupam
A
D006084:Graft Rejection / Q000453:epidemiology; D006801:Humans; D007194:India / Q000453:epidemiology; D017093:Liver Failure / Q000601:surgery / Q000628:therapy; D016031:Liver Transplantation / Q000276:immunology / Q000401:mortality; D011788:Quality of Life; D014019:Tissue Donors