Molecular mechanism of action of major Helicobacter pylori virulence factors.
Although Helicobacter pylori infects 50% of the total human population, only a small fraction of the infected people suffer from severe diseases like peptic ulcers and gastric adenocarcinoma. H. pylori strains, host genotypes and environmental factors play important role in deciding the extent and severity of the gastroduodenal diseases. The bacteria has developed a unique set of virulence factors to survive in the extreme ecological niche of human stomach. Together these virulence factors make H. pylori one of the most successful human pathogenic bacteria colonizing more than half of the human population. Understanding the mechanism of action of the major H. pylori virulence factors will shed light into the molecular basis of its pathogenicity.
Dhar
Suman Kumar
SK
Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India. skdhar2002@yahoo.co.in
Soni
Rajesh K
RK
Das
Bimal K
BK
Mukhopadhyay
Gauranga
G
D018829:Adhesins, Bacterial / Q000378:metabolism*; D001422:Bacterial Adhesion / Q000502:physiology; D001426:Bacterial Proteins / Q000378:metabolism*; D005407:Flagella / Q000378:metabolism; D016481:Helicobacter Infections / Q000188:drug therapy / Q000378:metabolism*; D016480:Helicobacter pylori / Q000378:metabolism* / Q000472:pathogenicity; D006801:Humans; D010437:Peptic Ulcer / Q000188:drug therapy / Q000378:metabolism; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000378:metabolism; D014510:Urease / Q000378:metabolism*; D014774:Virulence
D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; C074689:VacA protein, Helicobacter pylori; D014510:Urease