[Pharmacokinetics of osthole in rabbits].
OBJECTIVE
To investigate the pharmacokinetics of osthole in rabbits and obtain the main pharmacokinetic parameters.


METHODS
A simple high-performance liquid chromatography (HPLC) method was developed to study the pharmacokinetics of osthole in rabbits by joining an internal standard (paeonal). Methanol-water (80:20) was used as the mobile phase. According to the 3P87 pharmacokinetic program, the main parameters were calculated.


RESULTS
The osthole pharmacokinetics conforms to a two compartment open model after i.v. administration, T1/2 alpha = 5.81 min, T1/2 beta = 42.2 min, K21 = 0.036 0.min-1, K12 = 0.045 0.min-1, K10 = 0.054 0.min-1, AUC = 235 mg.min.L-1, CLs = 0.043 0 L.min-1.kg-1, Vc = 0.780 L.kg-1.


CONCLUSIONS
The pharmacokinetics of osthole after i.v. administration showed a rapid distribution and elimination process in rabbits.
An
Fang
F
Department of Chemistry and Pharmacology, Zhangjiakou Medical College, Zhangjiakou 075029, China.
Wang
Shu-hua
SH
Zhang
Dan-shen
DS
Zhang
Li
L
Mu
Jin-xiu
JX
D000818:Animals; D019540:Area Under Curve; D002121:Calcium Channel Blockers / Q000097:blood / Q000302:isolation & purification / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D031048:Cnidium / Q000737:chemistry*; D003374:Coumarins / Q000097:blood / Q000302:isolation & purification / Q000493:pharmacokinetics*; D005638:Fruit / Q000737:chemistry; D008297:Male; D008657:Metabolic Clearance Rate; D010946:Plants, Medicinal / Q000737:chemistry; D011817:Rabbits; D014018:Tissue Distribution
D002121:Calcium Channel Blockers; D003374:Coumarins; C046627:osthol