title: An autopsy case of acute pulmonary toxicity associated with gemcitabine.
abstract: Acute respiratory distress syndrome (ARDS) developed following intravenous gemcitabine monotherapy in a 75-year-old man with non-small cell lung cancer. The total dose of gemcitabine was 1,500 mg, and the latent period from starting gemcitabine to pulmonary toxicity was three days. The chest radiographs and high resolution computed tomographic scan revealed bilateral ground-glass opacity. He died on the fourteenth post-chemotherapeutic day due to respiratory failure. Postmortem examination of the lung revealed mixed exudative and fibrotic stages of diffuse alveolar damage. Pulmonary toxicity from gemcitabine can be acute and fatal.
authors: Department of Respiratory Medicine, Tenri Hospital, Nara.
authors: Ko
authors: K
authors: Maniwa
authors: Eisaku
authors: E
authors: Tanaka
authors: Tetsuro
authors: T
authors: Inoue
authors: Terufumi
authors: T
authors: Kato
authors: Minoru
authors: M
authors: Sakuramoto
authors: Masayoshi
authors: M
authors: Minakuchi
authors: Yuji
authors: Y
authors: Maeda
authors: Satoshi
authors: S
authors: Noma
authors: Yoichiro
authors: Y
authors: Kobashi
authors: Yoshio
authors: Y
authors: Taguchi
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy; D003841:Deoxycytidine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000473:pathology*; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000093542:Gemcitabine