Activity of the hypothalamic-pituitary-adrenocortical system and sleep-wake cycle in rats with acute systemic inflammation.
Activity of the hypothalamic-pituitary-adrenocortical system and EEG characteristics of the sleep-wake cycle were studied on adult male Wistar rats with acute inflammation produced by bacterial lipopolysaccharide in a dose of 250 microg/100 g body weight. Blood concentrations of adrenocorticotropic hormone and corticosterone increased by 6 and 10 times, respectively, 30 min after lipopolysaccharide administration and peaked 2 hours after challenge. In this period the sleep-wake cycle underwent the most pronounced changes that could be attributed to the stupor-like state observed in clinical practice. It was manifested in dissociation between locomotor activity of animals and EEG characteristics, suppression of EEG components in slow-wave sleep, increase in the number of beta-waves, and decrease in the number of delta-waves in EEG. In the present work we consider possible mechanisms of temporal relationships between activity of the hypothalamic-pituitary-adrenocortical system and disorganization of the sleep-wake cycle during acute systemic inflammation.
Eliava
M I
MI
I. M. Sechenov Institute of Evolutional Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg. m_eliava@hotmail.com
Grinevich
V V
VV
Oganesyan
G A
GA
D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000276:immunology; D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000276:immunology; D004569:Electroencephalography; D007030:Hypothalamo-Hypophyseal System / Q000276:immunology / Q000502:physiology*; D007249:Inflammation / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000276:immunology; D008297:Male; D009043:Motor Activity / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000276:immunology / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000502:physiology*; D014851:Wakefulness / Q000502:physiology*
D008070:Lipopolysaccharides; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone