title: Cognitive therapy versus fluoxetine in generalized social phobia: a randomized placebo-controlled trial.
abstract: Sixty patients meeting Diagnostic and Statistical Manual of Mental Disorders (4th ed.: American Psychiatric Association, 1994) criteria for generalized social phobia were assigned to cognitive therapy (CT), fluoxetine plus self-exposure (FLU + SE), or placebo plus self-exposure (PLA + SE). At posttreatment (16 weeks), the medication blind was broken. CT and FLU + SE patients then entered a 3-month booster phase. Assessments were at pretreatment, midtreatment, posttreatment, end of booster phase, and 12-month follow-up. Significant improvements were observed on most measures in all 3 treatments. On measures of social phobia, CT was superior to FLU + SE and PLA + SE at midtreatment and at posttreatment. FLU + SE and PLA + SE did not differ. CT remained superior to FLU + SE at the end of the booster period and at 12-month follow-up. On general mood measures, there were few differences between the treatments
authors: Department of Psychology, Institute of Psychiatry, London, United Kingdom. d.clark@iop.kcl.ac.uk
authors: David M
authors: DM
authors: Clark
authors: Anke
authors: A
authors: Ehlers
authors: Freda
authors: F
authors: McManus
authors: Ann
authors: A
authors: Hackmann
authors: Melanie
authors: M
authors: Fennell
authors: Helen
authors: H
authors: Campbell
authors: Teresa
authors: T
authors: Flower
authors: Clare
authors: C
authors: Davenport
authors: Beverley
authors: B
authors: Louis
mesh_terms: D000328:Adult; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D003887:Desensitization, Psychologic; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010698:Phobic Disorders / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D019233:Retreatment; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors