Neonatal food restriction induces hypoplasia in developing facial motor neurons of rats.
The effects of neonatal food restriction upon the dendritic development of facial nucleus (FN) motor neurons of Wistar rats were analyzed. Rats neonatally underfed by daily (12 h) mother-litter separation in an incubator from 5-30 days after birth exhibited, in brain stem Golgi-Cox sections, significant reductions in the number and extension of stellate, triangular and bipolar FN neuronal dendritic prolongations with negligible effects upon perikarya measurements. Data suggest that in the underfed newborn, the ability of FN neurons to establish synaptic contacts with afferent fibers is reduced, which then interferes with their capacities for the integration and triggering of nerve impulses to modulate facial motor expression in response to sensory cues.
Torrero
C
C
Department of Developmental Neurobiology and Neurophysiology, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Campus UNAM Juriquilla, Querétaro, Qro., 76001 México.
Regalado
M
M
Rubio
L
L
Ruiz-Marcos
A
A
Salas
M
M
D000818:Animals; D000831:Animals, Newborn; D001933:Brain Stem / Q000002:abnormalities / Q000254:growth & development*; D003712:Dendrites / Q000502:physiology; D004038:Diet, Reducing; D006799:Housing, Animal; D008297:Male; D023421:Models, Animal; D009474:Neurons / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology; D051381:Rats; D013569:Synapses / Q000502:physiology*