Pneumocystis carinii pneumonia: a late presentation following treatment for stage IV neuroblastoma.
This report describes a child who develops Pneumocystis carinii pneumonia 7 months after high-dose chemotherapy for stage IV neuroblastoma. In addition to chemotherapy the child had also been treated with abdominal radiotherapy and 13-cis-retinoic acid. Standard practice has been to treat patients with prophylactic co-trimoxazole for 3 months after high-dose therapy, but this report highlights the intensity and complexity of current treatment for stage IV neuroblastoma and the need to be aware of prolonged lymphopenia after such treatment.
Clarke
Edward
E
Department of Paediatric Oncology, St. James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.
Glaser
Adam W
AW
Picton
Susan V
SV
D000008:Abdominal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D016190:Carboplatin / Q000008:administration & dosage; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D015474:Isotretinoin / Q000627:therapeutic use; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D009894:Opportunistic Infections / Q000188:drug therapy / Q000209:etiology*; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy / Q000209:etiology*; D018714:Radiotherapy, Adjuvant; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D014750:Vincristine / Q000008:administration & dosage
D000305:Adrenal Cortex Hormones; D014750:Vincristine; D005047:Etoposide; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D003520:Cyclophosphamide; D016190:Carboplatin; D015474:Isotretinoin; D002945:Cisplatin