Application of genomics and proteomics in Type 1 diabetes pathogenesis research.
Type 1 diabetes is a polygenic, multifactorial autoimmune disease characterized by selective and irreversible destruction of the insulin-producing beta-cells in the pancreatic islets of Langerhans. An exogenous supply of insulin is required to sustain life after the onset of Type 1 diabetes. Despite decades of intensive research into its pathogenesis, no single gene or protein has been found to be responsible for Type 1 diabetes. This review will describe the use of large-scale genomics and proteomics in studying the pathogenesis of Type 1 diabetes, and will discuss future directions of research in the field.
Sparre
Thomas
T
Steno Diabetes Center, Gentofte, Denmark. tspa@steno.dk
Bergholdt
Regine
R
Nerup
Jørn
J
Pociot
Flemming
F
D000818:Animals; D019295:Computational Biology; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D015180:Electrophoresis, Gel, Two-Dimensional; D023281:Genomics; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D007515:Islets of Langerhans / Q000378:metabolism / Q000473:pathology; D010641:Phenotype; D040901:Proteomics
D007375:Interleukin-1