title: Scavenging effects of natural phenols on oxidizing intermediates of peroxynitrite.
abstract: Most of peroxynitrite (ONOO-/ONOOH) is formed via the diffusion-limited reaction between nitric oxide and superoxide. In biological systems, the decomposition of ONOO- yields 30-35% of carbonate radical (CO3*-) and nitrogen dioxide (NO2*), which are strongly oxidizing intermediates and are suggested to take a part of the responsibility for the toxicity of nitric oxide (NO*) or ONOO-. Therefore, the current study focuses on the scavenging activities of phenols toward CO3*- and NO2* to protect biomolecules from damage caused by NO* or ONOO- using the technique of pulse radiolysis. From the build-up kinetic of the phenoxyl radicals and the decay kinetic of CO3*- radical, the rate constants of scavenging reactions were determined to be 1.9-3.4 x 10(8) M(-1) x s(-1) and 0.11-1.9 x 10(8) M(-1) x s(-1) for CO3*- and NO2* respectively. The results indicated that the tested phenols are the efficient scavengers of CO3*- and NO2*.
authors: School of life Sciences, Lanzhou University, Lanzhou, P.R. China.
authors: C Y
authors: CY
authors: Zhao
authors: Y M
authors: YM
authors: Shi
authors: S D
authors: SD
authors: Yao
authors: Z J
authors: ZJ
authors: Jia
authors: B T
authors: BT
authors: Fan
authors: W F
authors: WF
authors: Wang
authors: W Z
authors: WZ
authors: Lin
authors: N Y
authors: NY
authors: Lin
authors: R L
authors: RL
authors: Zheng
mesh_terms: D002254:Carbonates / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry*; D007700:Kinetics; D009573:Nitrites / Q000737:chemistry; D010084:Oxidation-Reduction; D030421:Peroxynitrous Acid / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D011675:Pulse Radiolysis; D011794:Quercetin / Q000737:chemistry; D012431:Rutin / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002254:Carbonates; D016166:Free Radical Scavengers; D009573:Nitrites; D010636:Phenols; D030421:Peroxynitrous Acid; D012431:Rutin; D011794:Quercetin