title: Pulmonary mechanics after cardio-pulmonary transplantation, an experimental study.
abstract: An experimental model was developed in pigs (weight: 25 +/- 2 kg), to evaluate pulmonary mechanics during the first 2 h of reperfusion following heart-lung transplantation. We studied two groups with three transplantations each: group A (45 min of preservation) and group B (6 h of preservation). After rinsing out the heart-lung mass by the injection of a cold intracellular solution (K+ = 115 mEq/l) into the aorta and the pulmonary artery, the organs were removed and conserved in a cold environment (0.5 degrees C). The orthotopic heart-lung transplantation was carried out using extra-corporeal circulation. Pulmonary mechanics were evaluated before and after transplantation by measuring the pulmonary compliance (C), and the aero-dynamic resistance (R) with an interrupted air flow technique. [table: see text] The duration of ischaemia appeared to be a pernicious factor in cardiopulmonary function. In all cases, the protection protocol of the heart-lung block had allowed a cutting-off of the cardiorespiratory assistance. However, there were major pulmonary mechanical perturbations, associated with a reduction in the pulmonary compliance and a very important increase in the aerodynamic resistance.
authors: Laboratoire de Chirurgie expérimentale, Faculté de Médecine, C. H. U. de Brabois, Vandoeuvre les Nancy, France.
authors: J P
authors: JP
authors: Carteaux
authors: P M
authors: PM
authors: Mertes
authors: C
authors: C
authors: Dopff
authors: J
authors: J
authors: Borrely
authors: T
authors: T
authors: Hubert
authors: R
authors: R
authors: Peslin
authors: J P
authors: JP
authors: Villemot
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure; D002314:Cardioplegic Solutions; D006339:Heart Rate; D016041:Heart-Lung Transplantation / Q000502:physiology*; D008168:Lung / Q000502:physiology*; D008170:Lung Compliance; D023421:Models, Animal; D011651:Pulmonary Artery; D015424:Reperfusion; D012129:Respiratory Function Tests; D013552:Swine; D013997:Time Factors; D014184:Transplantation, Homologous / Q000502:physiology
chemical_list: D002314:Cardioplegic Solutions