On the relation between fluctuation and response in biological systems.
A general relationship between fluctuation and response in a biological system is presented. The fluctuation is given by the variance of some quantity, whereas the response is given as the average change of that quantity for a given parameter change. We propose a relationship where the two are proportional, in a similar way to the fluctuation-dissipation theorem in physics. By studying an evolution experiment where fluorescence of protein in bacteria increases, we confirm our relation by observing a positive correlation between the speed of fluorescence evolution and the phenotypic fluctuation of the fluorescence over clone bacteria. The generality of the relationship as well as its relevance to evolution is discussed.
Sato
Katsuhiko
K
Department of Pure and Applied Sciences, University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan.
Ito
Yoichiro
Y
Yomo
Tetsuya
T
Kaneko
Kunihiko
K
D005075:Biological Evolution; D055592:Biophysical Phenomena; D001703:Biophysics; D019020:Directed Molecular Evolution; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D049452:Green Fluorescent Proteins; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D009154:Mutation; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism
D008164:Luminescent Proteins; D011994:Recombinant Proteins; D049452:Green Fluorescent Proteins