New effects of type III effectors.
The enzymatic activities and/or targets of four type III effector proteins from plant pathogens have been reported in a flurry of new papers. In this issue, XopD is shown to remove SUMO groups from host cell proteins, while in previous issues of Molecular Microbiology, HopPtoD2 was shown to function as a tyrosine phosphatase and AvrRpt2 as probably a cysteine protease that targets the host RIN4 protein. Finally, AvrPphB is revealed in a recent Science paper to function as a cysteine protease that targets the host PBS1 kinase. This work is providing some of the first insights into how plant pathogens subvert host cell signalling machinery to cause disease.
Innes
Roger
R
Department of Biology, Indiana University, Bloomington, IN 47405-7107, USA. rinnes@indiana.edu
D001426:Bacterial Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D003546:Cysteine Endopeptidases / Q000378:metabolism; D005798:Genes, Bacterial; D010935:Plant Diseases / Q000382:microbiology*; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism
D001426:Bacterial Proteins; D017027:Protein Tyrosine Phosphatases; D003546:Cysteine Endopeptidases