Optical coherence tomography disc assessment in optic nerves with peripapillary atrophy.
OBJECTIVE
Optical coherence tomography (OCT) is able to determine the optic disc margin automatically. The aim of this study was to investigate the accuracy of the automatic OCT optic nerve head measurements in the presence of peripapillary atrophy.


METHODS
This was a cross-sectional, retrospective study. Thirty-one subjects with peripapillary atrophy underwent optic nerve head scanning with OCT version 3. Nineteen of the eyes were classified clinically as having glaucoma, nine had suspected glaucoma, and three were normal. Automatic OCT results were compared with manual tracing results.


RESULTS
Significant differences were found between most OCT optic nerve head automated and manual disc assessment parameters; however, good agreement was found between the two methods for all parameters (intraclass correlation, 0.71 to 0.94). Areas under receiver operator characteristics curves for clinical status were similar for all parameters with both methods.


CONCLUSIONS
Automated OCT optic nerve head analysis may be used in the clinical setting in the presence of peripapillary atrophy; however, caution should be used when comparing individual results with population-derived optic nerve head results.
Lai
Edward
E
New England Eye Center, Tufts-New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA.
Wollstein
Gadi
G
Price
Lori Lyn
LL
Paunescu
Lelia A
LA
Stark
Paul C
PC
Fujimoto
James G
JG
Schuman
Joel S
JS
D003430:Cross-Sectional Studies; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D015588:Observer Variation; D009798:Ocular Hypertension / Q000175:diagnosis; D009887:Ophthalmoscopy; D009896:Optic Atrophy / Q000175:diagnosis*; D009898:Optic Disk / Q000473:pathology*; D012372:ROC Curve; D015203:Reproducibility of Results; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014794:Visual Fields