CSF hypocretin measures in patients with obstructive sleep apnea.
The majority of patients with narcolepsy-cataplexy were reported to have very low cerebrospinal fluid (CSF) hypocretin-1 (orexin-A) levels. The hypocretin-1 levels of secondary excessive daytime sleepiness (EDS) disorders are not known. In this study, we found that CSF hypocretin levels in the patients with obstructive sleep apnea syndrome were within the control range. The low hypocretin levels seem to reflect only the presence of cataplexy and DR2 positive in narcoleptics but not EDS itself.
Kanbayashi
T
T
Inoue
Y
Y
Kawanishi
K
K
Takasaki
H
H
Aizawa
R
R
Takahashi
K
K
Ogawa
Y
Y
Abe
M
M
Hishikawa
Y
Y
Shimizu
T
T
D000328:Adult; D000368:Aged; D002352:Carrier Proteins / Q000134:cerebrospinal fluid*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000134:cerebrospinal fluid; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D000068797:Orexins; D020181:Sleep Apnea, Obstructive / Q000134:cerebrospinal fluid*
D002352:Carrier Proteins; C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins