Angiogenesis in the corpus luteum.
The corpus luteum (CL) is a site of intense angiogenesis. Within a short period, this is followed either by controlled regression of the microvascular tree in the non-fertile cycle, or maintenance and stabilisation of the new vasculature a conceptual cycle. The molecular regulation of these diverse aspects is examined. The CL provides a unique model system in which to study the cellular and molecular regulation of angiogenesis. Vascular endothelial growth factor (VEGF) has been found to have a major role in the CL. By targeting its action at specific stages of the luteal phase in vivo by antagonists, profound inhibitory effects on luteal angiogenesis and function are observed.
Fraser
Hamish M
HM
Medical Research Council Human Reproductive Sciences Unit, Centre for Reproductive Biology, 49 Little France Crescent, Edinburgh, EH16 4SB, UK. h.fraser@hrsu.mrc.ac.uk
Wulff
Christine
C
D000818:Animals; D003338:Corpus Luteum / Q000098:blood supply* / Q000166:cytology; D005260:Female; D006801:Humans; D008183:Luteal Phase / Q000097:blood / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000502:physiology*; D011247:Pregnancy