The mutagenic potentiator effect of chlorophyllin by the HGPRT assay.
Chlorophyllin, a sodium-copper salt derivative of chlorophyll-a and -b, was evaluated for antimutagenic activity against ethyl methane sulfonate by the hypoxanthin-guanine-phosphoribosyl transferase (HGPRT) assay. The results obtained suggest that this chlorophyllin can potentiate the mutagenicity of an alkylating agent which induces DNA damage.
Davidson Negraes
Priscilla
P
Universidade Estadual de Londrina, Departamento de Biologia Geral, Campus Universitario CP 6001, Laboratório de Mutagênese in vitro, Parana 86051 990, Brazil.
Quinzani Jordão
Berenice
B
Vicentini
Veronica Elisa Pimenta
VE
Mantovani
Mário Sérgio
MS
D000818:Animals; D016466:CHO Cells; D002735:Chlorophyllides / Q000009:adverse effects / Q000235:genetics* / Q000493:pharmacokinetics / Q000633:toxicity*; D006224:Cricetinae; D004249:DNA Damage / Q000187:drug effects / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D005020:Ethyl Methanesulfonate / Q000009:adverse effects; D005260:Female; D007041:Hypoxanthine Phosphoribosyltransferase / Q000187:drug effects* / Q000235:genetics; D016297:Mutagenesis, Site-Directed; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens / Q000009:adverse effects
D002735:Chlorophyllides; D009153:Mutagens; D005020:Ethyl Methanesulfonate; D007041:Hypoxanthine Phosphoribosyltransferase; C007020:chlorophyllin