title: Strain difference in pituitary-adrenal axis between Wistar-Imamichi and Long Evans adult male rats.
abstract: In the present study, we used closed colony-Wistar-Imamichi (WI), inbred WI and Long Evans (LE) adult male rats to examine the secretion of ACTH and corticosterone in response to restraint stress. Blood (0.3 ml) was withdrawn through a jugular cannula at 0, 15, 30, 60 and 120 min after the onset of restraint stress. Plasma concentrations of ACTH and corticosterone increased after stress in all groups, but the responses of ACTH and corticosterone secretion were higher in LE rats than in WI rats. Present data suggest that the LE rat might be a good model as a high-response strain and the closed colony or the inbred WI rat might be a good model as a low-response strain in restraint stress experiments.
authors: Laboratory Animal Research Center, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.
authors: Atsushi
authors: A
authors: Tohei
authors: Yasuyuki
authors: Y
authors: Mogi
authors: Hiroe
authors: H
authors: Kon
authors: Ryoji
authors: R
authors: Hokao
authors: Motoo
authors: M
authors: Shinoda
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D008297:Male; D023421:Models, Animal; D010913:Pituitary-Adrenal System / Q000378:metabolism*; D051381:Rats; D020318:Rats, Long-Evans; D017208:Rats, Wistar; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000503:physiopathology*
chemical_list: D000324:Adrenocorticotropic Hormone; D003345:Corticosterone