Heat shock protein-antigen presenting cell interactions.
The heat shock protein-antigen presenting cell interaction lies at the center of the unique properties of heat shock proteins as immunogens. This interaction is a key event in adaptive immune response elicited by heat shock protein-chaperoned peptides, naturally derived or artificially reconstituted. The heat shock protein-antigen presenting cell interaction results in a primitive and fundamental chain of events, i.e., translocation of the NF-kappaB complex into the nuclei of antigen presenting cells, leading to a chain of transcriptional events including secretion of cytokines and expression of various antigen presenting and co-stimulatory molecules. The heat shock protein-antigen presenting cell interaction thus results in enrollment of not only the adaptive but also the innate component of the immune response. Here, we discuss the different methods involved in the in vitro study, of heat shock protein-antigen presenting cell interactions.
Basu
Sreyashi
S
Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, MC1601, Farmington, CT 06030, USA. basu@up.uchc.edu
Matsutake
Toyoshi
T
D000595:Amino Acid Sequence; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D001854:Bone Marrow Cells / Q000276:immunology; D039481:CD11b Antigen / Q000276:immunology / Q000302:isolation & purification; D002460:Cell Line; D003713:Dendritic Cells / Q000276:immunology; D006360:Heat-Shock Proteins / Q000276:immunology* / Q000302:isolation & purification*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008969:Molecular Sequence Data; D016328:NF-kappa B / Q000378:metabolism; D010446:Peptide Fragments / Q000737:chemistry / Q000302:isolation & purification; D013154:Spleen / Q000276:immunology
D039481:CD11b Antigen; D006360:Heat-Shock Proteins; D016328:NF-kappa B; D010446:Peptide Fragments