title: Strain differences to effects of aging on concentrations of amino acids in cerebrospinal fluid between Sprague Dawley rat and Wistar Kyoto rat.
abstract: Age-related alterations and differences of weights and those of amino acid concentrations in the cerebrospinal fluid (CSF) were evaluated between Sprague Dawley (SD) rats and Wistar Kyoto (WKY) rats from eight to twenty weeks of age. The weights of SD rats were heavier than WKY rats at all ages. The age-related alterations of the CSF concentration of many amino acids within each strain were significant but showed no significant trend with age. Between the strains, the concentration differences of excitatory and inhibitory amino acids were not frequent although the concentrations of arginine, alanine and threonine were significantly higher in SD rats than in WKY rats. These results suggest that the different CSF concentrations of amino acids may relate to characteristics of rat strains.
authors: Department of Anesthesiology, School of Medicine, Kinki University, Osaka-sayama, Japan.
authors: Yoshihiro
authors: Y
authors: Takasugi
authors: Keiji
authors: K
authors: Kawata
authors: Takahiko
authors: T
authors: Okuda
authors: Yoshihisa
authors: Y
authors: Koga
authors: Nobuyuki
authors: N
authors: Mizuguchi
authors: Shigeaki
authors: S
authors: Yamanaka
authors: Shinsuke
authors: S
authors: Watanabe
mesh_terms: D000375:Aging / Q000134:cerebrospinal fluid* / Q000502:physiology*; D000596:Amino Acids / Q000134:cerebrospinal fluid*; D000818:Animals; D001120:Arginine / Q000134:cerebrospinal fluid; D001835:Body Weight; D008297:Male; D051381:Rats; D011921:Rats, Inbred WKY / Q000134:cerebrospinal fluid*; D017207:Rats, Sprague-Dawley / Q000134:cerebrospinal fluid*; D013912:Threonine / Q000134:cerebrospinal fluid
chemical_list: D000596:Amino Acids; D013912:Threonine; D001120:Arginine