Homo- and hetero-oligomerization of G protein-coupled receptors.
G protein-coupled receptors (GPCRs) form homo-oligomeric and hetero-oligomeric complexes. This understanding has prompted a re-evaluation of many aspects of GPCR biology, however the concept of receptor complexes has not been fully integrated into the current thinking about GPCR structure and function. Nevertheless, receptor oligomerization is a pivotal aspect of the structure and function of GPCRs that has been shown to have implications for receptor trafficking, signaling, and pharmacology and more intricate models for understanding the physiological roles of these receptors are emerging. Here, we summarize some of the advances made in understanding the structural basis and the functional roles of homo- and hetero- oligomerization in this important group of receptors. Although this discussion focuses primarily on the dopamine receptors, particularly the D2 dopamine receptor, and the opioid and serotonin receptors, we discuss the principles governing the oligomerization of all rhodopsin-like GPCRs and potentially of the entire superfamily of these receptors.
Lee
Samuel P
SP
Department of Pharmacology, University of Toronto, 1 King's College Circle, M5S 1A8, Toronto, Ontario, Canada.
O'Dowd
Brian F
BF
George
Susan R
SR
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008958:Models, Molecular; D011956:Receptors, Cell Surface / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*
D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled