Deep vein thrombosis and air travel: record linkage study.
OBJECTIVE
To investigate the time relations between long haul air travel and venous thromboembolism.


METHODS
Record linkage study using the case crossover approach.


METHODS
Western Australia.


METHODS
5408 patients admitted to hospital with venous thromboembolism and matched with data for arrivals of international flights during 1981-99.


RESULTS
The risk of venous thromboembolism is increased for only two weeks after a long haul flight; 46 Australian citizens and 200 non-Australian citizens had an episode of venous thromboembolism during this so called hazard period. The relative risk during this period for Australian citizens was 4.17 (95% confidence interval, 2.94 to 5.40), with 76% of cases (n = 35) attributable to the preceding flight. A "healthy traveller" effect was observed, particularly for Australian citizens.


CONCLUSIONS
The annual risk of venous thromboembolism is increased by 12% if one long haul flight is taken yearly. The average risk of death from flight related venous thromboembolism is small compared with that from motor vehicle crashes and injuries at work. The individual risk of death from flight related venous thromboembolism for people with certain pre-existing medical conditions is, however, likely to be greater than the average risk of 1 per 2 million for passengers arriving from a flight. Airlines and health authorities should continue to advise passengers on how to minimise risk.
Kelman
C W
CW
Commonwealth Department of Health and Ageing, GPO Box 9848, Canberra, ACT 2601, Australia. christopher.kelman@health.gov.au
Kortt
M A
MA
Becker
N G
NG
Li
Z
Z
Mathews
J D
JD
Guest
C S
CS
Holman
C D J
CD
D000293:Adolescent; D000328:Adult; D000337:Aerospace Medicine; D000368:Aged; D000401:Aircraft; D002648:Child; D002675:Child, Preschool; D018592:Cross-Over Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D016016:Proportional Hazards Models; D012307:Risk Factors; D013997:Time Factors; D014195:Travel; D020246:Venous Thrombosis / Q000453:epidemiology / Q000209:etiology*; D014904:Western Australia / Q000453:epidemiology