Reduction in homocysteine by n-3 polyunsaturated fatty acids after 1 year in a randomised double-blind study following an acute myocardial infarction: no effect on endothelial adhesion properties.
We hypothesized that n-3 polyunsaturated fatty acids (n-3 PUFAs) as compared to corn oil administered for 1 year following an acute myocardial infarction (MI) may reduce plasma total homocysteine (p-tHcy), ultrasensitive C-reactive protein (microCRP), and the adhesive properties of the endothelium, expressed as soluble E-selectin (sE-selectin) and soluble intercellular adhesion molecule-1 (sICAM-1). In a prospective, randomised, double-blind study, 300 acute MI patients were allocated to highly concentrated n-3 PUFAs (n = 150) or corn oil (n = 150). After 1 year on treatment there was an intergroup difference in p-tHcy in favour of the n-3 group (n = 118), p = 0.022. However, sE-selectin, sICAM-1 and microCRP were unaffected by the treatment. In conclusion, reduction of p-tHcy by long-term n-3 PUFAs treatment was not associated with demonstrable effects on markers of endothelial adhesion properties.
Grundt
Heidi
H
Department of Clinical Chemistry, Central Hospital in Rogaland, Stavanger, Norway. heidi@madlalia.no
Nilsen
Dennis W T
DW
Mansoor
Mohammad A
MA
Hetland
Øyvind
Ø
Nordøy
Arne
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002448:Cell Adhesion / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000032:analysis; D003314:Corn Oil / Q000008:administration & dosage / Q000494:pharmacology; D004311:Double-Blind Method; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000178:diet therapy* / Q000188:drug therapy / Q000473:pathology; D013997:Time Factors
D015815:Cell Adhesion Molecules; D015525:Fatty Acids, Omega-3; D006710:Homocysteine; D003314:Corn Oil