Polarographic determination of ciclopirox olamine in pure substance and in different pharmaceutical preparations.
Two simple and sensitive methods are described for the determination of ciclopirox olamine in its pure form and different dosage forms. The proposed method depends upon the polarographic activity of ciclopirox olamine at the dropping mercury electrode (DME) in Britton Robinson buffer, whereby, well-defined cathodic waves were produced over the pH range 7-9. The polarographic wave was characterized as being irreversible diffusion-controlled with limited adsorption properties. The current-concentration relationship was found to be rectilinear over the range 8-32 and 2-12 microg ml(-1) using direct current (dct) and differential pulse polarographic (DPP) modes respectively, with minimum detectability of 0.53 microg ml(-1) (2.65 x 10(-6) M) and 0.1 microg ml(-1) (5 x 10(-7) M) using the dct and DPP modes, respectively. The average percent recovery was favorably compared to spectrophotometric method. The proposed method was further applied to dosage forms including ciclopirox lotion and cream. The average percentage recoveries for lotion were 100.34+/-0.84 and 99.96+/-1.06 using dct and DPP modes, respectively, and for cream were 100.53+/-0.59 and 100.02+/-0.89 using dct and DPP modes, respectively.
Ibrahim
F
F
Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, 35516 Mansoura, Egypt. f_ibrahim144@yahoo.com
El-Enany
N
N
D002021:Buffers; D000077768:Ciclopirox; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011048:Polarography / Q000379:methods*; D011728:Pyridones / Q000737:chemistry*
D002021:Buffers; D004364:Pharmaceutical Preparations; D011728:Pyridones; D000077768:Ciclopirox