title: The polycythaemia rubra vera-1 gene is constitutively expressed by bone marrow cells and does not discriminate polycythaemia vera from reactive and other chronic myeloproliferative disorders.
abstract: Little is known about the expression of the polycythaemia rubra vera-1 (PRV-1) gene in bone marrow cells. To determine the expression level of PRV-1 in the bone marrow, we analysed PRV-1 quantitatively in Polycythaemia vera, other chronic myeloproliferative disorders, and reactive states. We demonstrated that PRV-1 was constitutively expressed in both myeloproliferative and reactive states. We concluded that, rather than an upregulation of the PRV-1 gene in the clonal haematopoiesis of polycythaemia vera, a failure to downregulate PRV-1 in granulocytes emigrating from the bone marrow might be responsible for the increase of transcripts in peripheral cells.
authors: Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany. Bock.Oliver@MH-Hannover.de
authors: Oliver
authors: O
authors: Bock
authors: Ebru
authors: E
authors: Serinsöz
authors: Michael
authors: M
authors: Neusch
authors: Jerome
authors: J
authors: Schlué
authors: Hans
authors: H
authors: Kreipe
mesh_terms: D001854:Bone Marrow Cells / Q000378:metabolism*; D058851:GPI-Linked Proteins; D015870:Gene Expression; D005819:Genetic Markers; D006098:Granulocytes / Q000378:metabolism; D006410:Hematopoiesis / Q000235:genetics; D006801:Humans; D007519:Isoantigens; D008562:Membrane Glycoproteins; D009196:Myeloproliferative Disorders / Q000378:metabolism; D011087:Polycythemia Vera / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: C407242:CD177 protein, human; D058851:GPI-Linked Proteins; D005819:Genetic Markers; D007519:Isoantigens; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface