Tissue engineering and cell based therapies, from the bench to the clinic: the potential to replace, repair and regenerate.
The field of Regenerative Biology as it applies to Regenerative Medicine is an increasingly expanding area of research with hopes of providing therapeutic treatments for diseases and/or injuries that conventional medicines and even new biologic drug therapies cannot effectively treat. Extensive research in the area of Regenerative Medicine is focused on the development of cells, tissues and organs for the purpose of restoring function through transplantation. The general belief is that replacement, repair and restoration of function is best accomplished by cells, tissues or organs that can perform the appropriate physiologic/metabolic duties better than any mechanical device, recombinant protein therapeutic or chemical compound. Several strategies are currently being investigated and include, cell therapies derived from autologous primary cell isolates, cell therapies derived from established cell lines, cell therapies derived from a variety of stem cells, including bone marrow/mesenchymal stem cells, cord blood stem cells, embryonic stem cells, as well as cells tissues and organs from genetically modified animals. This mini-review is not meant to be exhaustive, but aims to highlight clinical applications for the four areas of research listed above and will address a few key advances and a few of the hurdles yet to be overcome as the technology and science improve the likelihood that Regenerative Medicine will become clinically routine.
Fodor
William L
WL
Center for Regenerative Biology and Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06250-4243, USA. william.fodor@uconn.edu
D000818:Animals; D030801:Animals, Genetically Modified; D016026:Bone Marrow Transplantation; D017690:Cell Transplantation; D002986:Clinical Trials as Topic; D005544:Forecasting; D006801:Humans; D012038:Regeneration; D044968:Regenerative Medicine / Q000639:trends*; D033581:Stem Cell Transplantation; D013552:Swine; D023822:Tissue Engineering / Q000639:trends*; D014182:Transplantation, Autologous; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous