title: Development of silicone rubber hollow fiber membrane oxygenator for ECMO.
abstract: Silicone rubber hollow fiber membrane produces an ideal gas exchange for long-term ECMO due to nonporous characteristics. The extracapillary type silicone rubber ECMO oxygenator having an ultrathin hollow fiber membrane was developed for pediatric application. The test modules were compared to conventional silicone coil-type ECMO modules. In vitro experiments demonstrated a higher O2 and CO2 transfer rate, lower blood flow resistance, and less hemolysis than the conventional silicone coil-type modules. This oxygenator was combined with the Gyro C1E3 centrifugal pump, and three ex vivo experiments were conducted to simulate pediatric V-A ECMO condition. Four day and 6 day experiments were conducted in cases 1 and 2, respectively. Case 3 was a long-term experiment up to 2 weeks. No plasma leakage and stable gas performances were achieved. The plasma free hemoglobin was maintained within a normal range. This compact pump-oxygenator system in conjunction with the Gyro C1E3 centrifugal pump has potential for a hybrid total ECMO system.
authors: Baylor College of Medicine, Michael E. DeBakey Department of Surgery, Houston, TX 77054, USA. Motomura@bcm.tmc.edu
authors: Tadashi
authors: T
authors: Motomura
authors: Tomohiro
authors: T
authors: Maeda
authors: Shiniji
authors: S
authors: Kawahito
authors: Takahiro
authors: T
authors: Matsui
authors: Seiji
authors: S
authors: Ichikawa
authors: Hiroshi
authors: H
authors: Ishitoya
authors: Masaki
authors: M
authors: Kawamura
authors: Toshiyuki
authors: T
authors: Shinohara
authors: Koshiro
authors: K
authors: Sato
authors: Yoichiro
authors: Y
authors: Kawaguchi
authors: Deborah
authors: D
authors: Taylor
authors: Daniel
authors: D
authors: Oestmann
authors: Julie
authors: J
authors: Glueck
authors: Yukihiko
authors: Y
authors: Nosé
mesh_terms: D000818:Animals; D002417:Cattle; D015199:Extracorporeal Membrane Oxygenation; D006454:Hemoglobins / Q000032:analysis; D008422:Materials Testing; D010107:Oxygenators, Membrane; D012826:Silicone Elastomers
chemical_list: D006454:Hemoglobins; D012826:Silicone Elastomers