Toll-like receptor 4 plays no role in susceptibility of mice to Mycobacterium tuberculosis infection.
Although various members of the pattern recognition Toll-like receptor (TLR) family have been implicated in host resistance to Mycobacterium tuberculosis infection, it remains unclear if the TLR4 receptor plays an important role. We demonstrate here that infection of TRL4-competent and TLR4-deficient mice on the C3H inbred mouse strain background had similar outcomes, measured in terms of the course of the disease, cell accumulation patterns in the lungs, and lung histopathology. These data argue against a significant role for TLR4 in immunity to tuberculosis in the mouse model.
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Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA.
Turner
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Orme
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D000818:Animals; D004198:Disease Susceptibility / Q000276:immunology; D005434:Flow Cytometry / Q000379:methods; D008562:Membrane Glycoproteins / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D011956:Receptors, Cell Surface / Q000276:immunology*; D013154:Spleen / Q000276:immunology / Q000473:pathology; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors; D014376:Tuberculosis / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology
D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors