Secretory and vascular effects of adrenomedullin in gastric ulcer: role of CGRP- and adrenomedullin-receptors.
Adrenomedullin prevents damage of gastric mucosa in either reserpine-treated or pylorus-ligated rats. Pre-treatment with CGRP(8-37) resulted in a decrease of the gastro-protective effect of adrenomedullin in both models and reversed the inhibitory effect of adrenomedullin on gastric acid output in the pylorus-ligated rats. These adrenomedullin actions were less effectively modified by pre-treatment with adrenomedullin(22-52). These data suggest that the anti-ulcer effect of adrenomedullin is mainly related to its anti-secretory action, presumably mediated through CGRP-receptors.
Salomone
Salvatore
S
Dipartimento di Farmacologia Sperimentale e Clinica, Facoltà di Medicina e Chirurgia, Università di Catania, Viale A. Doria 6, Catania 95125, Italy.
Caruso
Antonina
A
Martinez
Giuseppa
G
Cutuli
Vincenza Maria
VM
Prato
Agata
A
Bianchi
Alfredo
A
Amico-Roxas
Matilde
M
Clementi
Giuseppe
G
D053607:Adrenomedullin; D000818:Animals; D006801:Humans; D008297:Male; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D058265:Receptors, Adrenomedullin; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000378:metabolism*; D018000:Receptors, Peptide / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D013276:Stomach Ulcer / Q000378:metabolism*
D010455:Peptides; D058265:Receptors, Adrenomedullin; D018015:Receptors, Calcitonin Gene-Related Peptide; D018000:Receptors, Peptide; D053607:Adrenomedullin; D012701:Serotonin