title: Thrombin interaction with platelet membrane glycoprotein Ib alpha.
abstract: The interaction of thrombin with platelet glycoprotein Ibalpha (GPIb alpha) is required for optimal platelet activation. The crystal structures of platelet GPIb alpha bound to thrombin reported by Dumas et al. and Celikel et al. both reveal the simultaneous interaction of GPIb alpha with thrombin exosites I and II but differ markedly regarding how the two proteins interact. The possible consequences on thrombus formation of thrombin interacting with GPIb alpha are discussed in light of these new data.
authors: INSERM E348, Faculté de Médecine Xavier Bichat, 16 rue Henri Huchard, 75870 Paris Cedex 18, France.
authors: Frédéric
authors: F
authors: Adam
authors: Marie-Christine
authors: MC
authors: Bouton
authors: Marie-Geneviève
authors: MG
authors: Huisse
authors: Martine
authors: M
authors: Jandrot-Perrus
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D001792:Blood Platelets / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D010766:Phosphorylation; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000378:metabolism*; D013917:Thrombin / Q000378:metabolism*
chemical_list: D019038:Platelet Glycoprotein GPIb-IX Complex; D013917:Thrombin