TMC-260, a new inhibitor of IL-4 signal transduction produced by Acremonium kiliense Grütz TC 1703.
Sakurai
Masaaki
M
Discovery & Pharmacology Research Laboratories, Tanabe Seiyaku Co., Ltd., 2-50 Kawagishi-2-chome, Toda-shi, Saitama 335-8505, Japan. sakura@tanabe.co.jp
Hoshino
Hiroyuki
H
Kohno
Jun
J
Nishio
Maki
M
Kishi
Noboru
N
Okuda
Toru
T
Kawano
Kimio
K
Ohnuki
Tetsuo
T
D000164:Acremonium / Q000254:growth & development / Q000378:metabolism*; D002460:Cell Line; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015847:Interleukin-4 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects*
D011760:Pyrrolidinones; C479707:TMC 260; D015847:Interleukin-4