title: Human sperm associated antigen 4 (SPAG4) is a potential cancer marker.
abstract: Using a combination of database screening and polymerase chain reaction analyses we have determined the sequence and structure of the human sperm tail associated gene SPAG4. SPAG4 is a 12-exon gene spanning approximately 5.2 kb on chromosome 20q11.23. It is expressed in a limited number of normal tissues, notably the pancreas and testis, but is switched on and greatly upregulated in a wide range of neoplastic tissues. The data therefore strongly suggests that SPAG4 expression is a potential clinically relevant cancer marker.
authors: Monash Institute of Reproduction and Development and The ARC Centre of Excellence in Biotechnology and Development, Monash University, 3168 Melbourne, Australia.
authors: Claire
authors: C
authors: Kennedy
authors: Kim
authors: K
authors: Sebire
authors: David M
authors: DM
authors: de Kretser
authors: Moira K
authors: MK
authors: O'Bryan
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D003001:Cloning, Molecular; D019295:Computational Biology; D018076:DNA, Complementary / Q000235:genetics; D005091:Exons / Q000235:genetics; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000235:genetics*; D013094:Spermatozoa / Q000378:metabolism*; D014018:Tissue Distribution / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D018076:DNA, Complementary; C114799:SPAG4 protein, human