title: [Intratympanic interval therapy of Menière disease with gentamicin with preserving cochlear function].
abstract: For the effective treatment of Menière's disease, gentamicin should be administered at most three times: on days 1, 8 and 15. More than 50% ( n=30) of 57 patients seen between 1997 and 2000 only needed a single dose of gentamicin to obtain a sufficient reaction (single shot-therapy). Vertigo attacks were controlled in 95% of our 57 patients and there were no substantial hearing losses. Four patients lost 15 dB. Tinnitus (46%) and ear pressure (69%) could be controlled or improved. The intratympanic injection-technique (single dose=0.3 ml=12 mg) performed under local anaesthesia is simple and superior to any other procedure. The peak concentration of gentamicin is reached after 2-6 days (average 4.6 days). As soon as signs of inner ear reaction are observed, treatment has been effective and must be stopped immediately to avoid over-intoxication and damage to the cochlea.
authors: HNO-Klinik der Johannes-Gutenberg-Universität Mainz.
authors: G
authors: G
authors: Lange
authors: W
authors: W
authors: Mann
authors: J
authors: J
authors: Maurer
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001301:Audiometry, Pure-Tone; D001302:Audiometry, Speech; D002150:Caloric Tests; D003051:Cochlea / Q000187:drug effects*; D003638:Deafness / Q000139:chemically induced / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004432:Ear, Middle / Q000187:drug effects; D005500:Follow-Up Studies; D005839:Gentamicins / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007267:Injections; D008575:Meniere Disease / Q000175:diagnosis / Q000188:drug therapy*; D004856:Postural Balance / Q000187:drug effects; D012307:Risk Factors; D014012:Tinnitus / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins