Intercellular adhesion molecule 1 (ICAM-1) induction on hepatocytes is an early marker of acute liver allograft rejection.
Intercellular adhesion molecule 1 (ICAM-1) induction on hepatocytes was investigated in relation to immune activation of acute liver allograft rejection. Twelve liver recipients undergoing an episode of acute rejection were monitored by frequent fine needle aspiration biopsy (FNAB) study. All episodes were reversible, and the lymphocyte and lymphoid blast predominated with a high peak of inflammation (6.9 +/- 4.0 corrected increment units). The rejections were treated with a high dose of steroids, and the inflammation subsided within 1 week. ICAM-1 was demonstrated from FNAB preparations by a monoclonal antibody and immunoperoxidase staining. ICAM-1 was not detected on the hepatocytes immediately after transplantation but was always seen during rejection. ICAM-1 appeared 1-5 days before the onset of inflammation in the FNAB. The intensity of ICAM-1 expression increased towards the peak of inflammation and subsided thereafter. ICAM-1 induction on hepatocytes appears to be linked with a very early phase of immune activation and can be considered an early marker for acute liver allograft rejection in the FNAB.
Lautenschlager
I
I
Transplantation Laboratory, Fourth Department of Surgery, University of Helsinki, Helsinki, Finland.
Höckerstedt
K
K
Häyry
P
P
D015415:Biomarkers / Q000097:blood; D044963:Biopsy, Fine-Needle; D004359:Drug Therapy, Combination; D006084:Graft Rejection / Q000473:pathology*; D022781:Hepatocytes / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis / Q000378:metabolism*; D016031:Liver Transplantation / Q000276:immunology* / Q000473:pathology
D015415:Biomarkers; D007166:Immunosuppressive Agents; D018799:Intercellular Adhesion Molecule-1