title: Central venous catheter related thrombosis in haematology patients and prediction of risk by screening with Doppler-ultrasound.
abstract: Patients with a central venous catheter (CVC) who receive intensive chemotherapy or a stem cell transplantation for haematological disease are at risk for developing CVC-related thrombosis. To study the incidence of thrombosis, 105 consecutive patients underwent serial Doppler-ultrasound and we evaluated whether clinically manifest thrombosis could be predicted by screening with Doppler-ultrasound. Patients with subclavian or jugular inserted CVCs were clinically assessed each day for signs and symptoms of thrombosis. Additional Doppler-ultrasound screens were performed weekly by an independent physician in all patients until CVC removal. Doppler-ultrasound recordings were assessed by two blinded observers. In cases of clinically suspected thrombosis, the attending physicians followed routine diagnostic and therapeutic procedures. The overall cumulative incidence of CVC-related thrombosis was 28.6% (30 of 105 patients). Of the 30 patients with thrombosis, 26 had subclinical thrombosis by Doppler-ultrasound, nine of whom developed clinically manifest thrombosis later. Four patients had clinically manifest thrombosis without prior abnormal Doppler-ultrasound. In cases of subclinical thrombosis the risk of developing symptomatic disease increased sevenfold (34.6% vs. 5.1%). Doppler-ultrasound screening may be useful to identify those patients that are at high and low risk for clinically manifest CVC-related thrombosis.
authors: Department of General Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.
authors: Cornelis J
authors: CJ
authors: van Rooden
authors: Frits R
authors: FR
authors: Rosendaal
authors: Renée M Y
authors: RM
authors: Barge
authors: Jacques A
authors: JA
authors: van Oostayen
authors: Felix J M
authors: FJ
authors: van der Meer
authors: A Edo
authors: AE
authors: Meinders
authors: Menno V
authors: MV
authors: Huisman
mesh_terms: D002405:Catheterization, Central Venous / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007601:Jugular Veins / Q000000981:diagnostic imaging*; D007938:Leukemia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000188:drug therapy; D011446:Prospective Studies; D018570:Risk Assessment; D033581:Stem Cell Transplantation; D013350:Subclavian Vein / Q000000981:diagnostic imaging*; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology*; D018608:Ultrasonography, Doppler