A Y chromosomal influence on prostate cancer risk: the multi-ethnic cohort study.
BACKGROUND
A Y chromosomal role in prostate cancer has previously been suggested by both cytogenetic findings and patterns of Y chromosomal gene expression. We took advantage of the well established and stable phylogeny of the non-recombining segment of the Y chromosome to investigate the association between Y chromosomal DNA variation and prostate cancer risk.


METHODS
We examined the distribution of 116 Y lineages in 930 prostate cancer cases and 1208 controls from four ethnic groups from a cohort study in Hawaii and California.


RESULTS
One lineage, found only among the Japanese group in our study, was associated with a statistically significant predisposition to prostate cancer (odds ratio (OR) = 1.63; 95% confidence interval (CI) 1.07 to 2.47), and, in particular, to high severity disease in younger individuals (OR = 3.89; 95% CI 1.34 to 11.31).


CONCLUSIONS
This finding suggests that a Y chromosomal factor contributes significantly to the development of prostate cancer in Japanese men.
Paracchini
S
S
Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
Pearce
C L
CL
Kolonel
L N
LN
Altshuler
D
D
Henderson
B E
BE
Tyler-Smith
C
C
D000368:Aged; D016022:Case-Control Studies; D041322:Chromosomes, Human, Y / Q000502:physiology*; D015331:Cohort Studies; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011471:Prostatic Neoplasms / Q000145:classification / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D012307:Risk Factors
D005819:Genetic Markers