Necrotizing eosinophilic folliculitis with mucinosis.
A 23-year-old woman presented with a 2-week history of an extensive facial eruption consisting of markedly crusted arciform plaques covered with a haemorrhagic eschar that commenced as pruritic follicular pustules. These were associated with facial oedema but no systemic symptoms or fever. Two skin biopsies revealed prominent tissue eosinophilia with eosinophilic folliculitis and areas of follicular mucinosis, as well as haemorrhagic scale crust over the surface. The clinical and histological findings may represent an example of a necrotizing variant of eosinophilic folliculitis that has recently been reported in atopic individuals. This patient, however, did not have evidence of atopy and appeared to have a florid form of Ofuji's disease that responded rapidly to indomethacin treatment.
Kossard
Steven
S
Skin and Cancer Foundation Australia, Sydney, New South Wales, Australia. skossard@scfa.edu.au
D000328:Adult; D001707:Biopsy, Needle; D004802:Eosinophilia / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D005148:Facial Dermatoses / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D005260:Female; D005499:Folliculitis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007213:Indomethacin / Q000008:administration & dosage; D017520:Mucinoses / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
D007213:Indomethacin