[Pancytopenia and ARDS with high dose hepatic arterial infusion].
The patient was a 74-year-old woman with gastric cancer with multiple liver metastasis. She was treated with daily oral administration of TS-1 100 mg/day (day 1-21) and systemic administration of CDDP 90 mg (day 8) as neoadjuvant chemotherapy for 2 courses. As metastatic lesions became smaller, we performed distal gastrectomy. TS-1 was started for the residual cancer lesion. However, liver metastatic lesions increased in size, so we carried out intraarterial chemotherapy (IAC), Nausea appeared at 9 days, pancytopenia at 28 days and ARDS at 78 days after IAC. She died due to ARDS.
Maruyama
Naomi
N
Dept. of Surgery, Suita Municipal Hospital.
Maruyama
Kentaro
K
Furukawa
Jyunkou
J
Nagai
Kenichi
K
Tanaka
Jyunichi
J
Katsumoto
Yosihiro
Y
Yokouchi
Hideoki
H
Nakaguchi
Kazunori
K
Kinuta
Masakatu
M
Sue
Fumiaki
F
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D005743:Gastrectomy; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary; D010094:Oxonic Acid / Q000008:administration & dosage; D010198:Pancytopenia / Q000139:chemically induced*; D011725:Pyridines / Q000008:administration & dosage; D012128:Respiratory Distress Syndrome / Q000139:chemically induced*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage
D000964:Antimetabolites, Antineoplastic; D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin; D005472:Fluorouracil