title: One-dimensional viscoelastic behavior of fibroblast populated collagen matrices.
abstract: Bio-artificial tissues are being developed as replacements for damaged biologic tissues. Their mechanical properties are critical for load bearing applications. Current testing protocols for bio-artificial tissues vary widely and often do not consider viscoelasticity. Uniaxial stretch tests were performed on fibroblast populated collagen matrices (FPCMs) to determine the influence of specific test protocols on the mechanical behavior. The peak force, hysteresis and shape of the force-stretch curve are affected by the stretch rate, rest period, stretch amplitude and the number and magnitude of preconditioning cycles.
authors: Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S. Euclid, CB 8228, St. Louis, MO 63110, USA. Jessica.Wagenseil@cellbio.wustl.edu
authors: Jessica E
authors: JE
authors: Wagenseil
authors: Tetsuro
authors: T
authors: Wakatsuki
authors: Ruth J
authors: RJ
authors: Okamoto
authors: George I
authors: GI
authors: Zahalak
authors: Elliot L
authors: EL
authors: Elson
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D016880:Anisotropy; D040761:Biomimetic Materials / Q000378:metabolism*; D002642:Chick Embryo; D003094:Collagen / Q000502:physiology*; D046508:Culture Techniques / Q000379:methods*; D004548:Elasticity; D005109:Extracellular Matrix / Q000502:physiology*; D005347:Fibroblasts / Q000502:physiology*; D008422:Materials Testing / Q000379:methods*; D010812:Physical Stimulation / Q000379:methods; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D023822:Tissue Engineering / Q000379:methods*; D014783:Viscosity; D016474:Weight-Bearing / Q000502:physiology
chemical_list: D003094:Collagen