Oxidative killing of microbes by neutrophils.
Neutrophils and other phagocytic leukocytes contain a phagocyte NADPH oxidase enzyme that generates superoxide after cell activation. Reactive oxygen species derived from superoxide, together with proteases liberated from the granules, are used to kill ingested microbes. Dysfunction of the phagocyte NADPH oxidase results in chronic granulomatous disease, with life-threatening infections.
Roos
Dirk
D
Sanquin Research at CLB, and Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands. d.roos@sanquin.nl
van Bruggen
Robin
R
Meischl
Christof
C
D001770:Blood Bactericidal Activity; D006105:Granulomatous Disease, Chronic / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D019255:NADPH Oxidases / Q000378:metabolism*; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology*; D010084:Oxidation-Reduction
D019255:NADPH Oxidases