Childhood autoimmune cytopenia secondary to unsuspected common variable immunodeficiency.
Immune thrombocytopenic purpura and autoimmune hemolytic anemia are typically idiopathic processes without underlying systemic illness. Four children with autoimmune cytopenia had low immunoglobulin levels that led to the diagnosis of common variable immunodeficiency. Routine screening of immunoglobulins is suggested for children with chronic or recurrent immune thrombocytopenic purpura and autoimmune hemolytic anemia.
Heeney
Matthew M
MM
Division of Hematology/Oncology, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA.
Zimmerman
Sherri A
SA
Ware
Russell E
RE
D000293:Adolescent; D015703:Antigens, CD / Q000097:blood / Q000276:immunology; D002675:Child, Preschool; D002908:Chronic Disease; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology; D007223:Infant; D008297:Male; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology
D015703:Antigens, CD; D007136:Immunoglobulins