title: Role of leukotrienes B4 and C4 in liver allograft rejection.
abstract: Previous studies have shown that eicosanoids may act in vitro as immunoregulatory substances. In this study, the concentrations of leukotriene B4 (LTB4) and leukotriene C4 (LTC4) were measured in a model of allograft rejection. Six orthotopic allotransplants of the liver were performed in dogs without the administration of immunosuppressives. LTB4 levels showed an increase coinciding with the start of rejection, significant differences being present between the basal levels and those measured 24 h post-revascularization (P < 0.05), and every day from the 3rd postoperative day (P < 0.01). LTB4 rose before the parameters generally used in evaluating rejection. LTC4 levels increased significantly (P < 0.001) in the first 24 h, and experienced no further variations. LTB4 may play an important role in the mechanisms which bring about the response to the allograft. This substance could be a specific and early marker for rejection.
authors: The Department of Surgery, Clínica Universitaria, University of Navarra, Navarra, Spain.
authors: J
authors: J
authors: González
authors: J A
authors: JA
authors: Cienfuegos
authors: F
authors: F
authors: Pardo
authors: J
authors: J
authors: Sola
authors: J L
authors: JL
authors: Hernández
authors: C
authors: C
authors: Rodríguez-Ortigosa
authors: C
authors: C
authors: Benito
authors: E
authors: E
authors: Balén
authors: F J
authors: FJ
authors: Pardo
authors: J
authors: J
authors: Quiroga
mesh_terms: D000818:Animals; D006084:Graft Rejection / Q000276:immunology*; D007975:Leukotriene B4 / Q000097:blood*; D017997:Leukotriene C4 / Q000097:blood*; D016031:Liver Transplantation / Q000276:immunology*; D013552:Swine; D014184:Transplantation, Homologous / Q000276:immunology
chemical_list: D007975:Leukotriene B4; D017997:Leukotriene C4