Total synthesis and reassessment of the phosphatase-inhibitory activity of the antitumor agent TMC-69-6H.
Fürstner
Alois
A
Max-Planck-Institut für Kohlenforschung, 45 470 Mülheim an der Ruhr, Germany. fuerstner@mpi-muelheim.mpg.de
Feyen
Fabian
F
Prinz
Heino
H
Waldmann
Herbert
H
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002384:Catalysis; D018797:Cell Cycle Proteins / Q000138:chemical synthesis*; D006865:Hydrogenation; D020128:Inhibitory Concentration 50; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D009596:Nitrophenols / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry; D010084:Oxidation-Reduction; D010165:Palladium; D011714:Pyrans / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors*
D000970:Antineoplastic Agents; D018797:Cell Cycle Proteins; D007527:Isoenzymes; D009596:Nitrophenols; D009943:Organophosphorus Compounds; D011714:Pyrans; C433007:TMC-69-6H; C008644:nitrophenylphosphate; D010165:Palladium; D020687:cdc25 Phosphatases