title: A mob of reps.
abstract: Emerging structural results confirm that the large Rolling Circle Replication initiator superfamily is composed of two classes of proteins that are circularly permutated with respect to each other, as initially suggested by sequence analysis. The two classes are united by the same endonucleolytic mechanism and a conserved Mg(2+) binding site containing multiple histidine ligands unique to this superfamily.
authors: Laboratory of Molecular Biology, HHS/NIH/NIDDK, Building 5, Room 303, Bethesda, MD 20892, USA.
authors: Fred
authors: F
authors: Dyda
authors: Alison Burgess
authors: AB
authors: Hickman
mesh_terms: D020816:Amino Acid Motifs; D001665:Binding Sites; D003227:Conjugation, Genetic; D018360:Crystallography, X-Ray; D004265:DNA Helicases / Q000502:physiology; D004267:DNA Viruses / Q000378:metabolism; D004269:DNA, Bacterial; D004277:DNA, Single-Stranded / Q000737:chemistry; D004268:DNA-Binding Proteins; D019992:Databases as Topic; D004720:Endonucleases / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D005144:F Factor / Q000737:chemistry; D006639:Histidine / Q000737:chemistry; D007477:Ions; D008024:Ligands; D008274:Magnesium / Q000737:chemistry*; D010957:Plasmids / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D018741:Replication Origin; D015534:Trans-Activators / Q000502:physiology; D014443:Tyrosine / Q000737:chemistry; D014961:X-Ray Diffraction; D015032:Zinc / Q000737:chemistry
chemical_list: D004269:DNA, Bacterial; D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins; D007477:Ions; D008024:Ligands; D015534:Trans-Activators; C045264:replication initiator protein; D014443:Tyrosine; D006639:Histidine; D004720:Endonucleases; D004265:DNA Helicases; D008274:Magnesium; D015032:Zinc