Distinct cytokine profile in SIDS brain: a common denominator in a multifactorial syndrome?
Cytokines modify neuronal function. Dysfunction in vital centers is reported in sudden infant death syndrome (SIDS). The authors detected high neuronal interleukin (IL)-1beta immunoreactivity in the arcuate and dorsal vagal nuclei in SIDS. This IL-1 overexpression might contribute to molecular interactions in brainstem neurovegetative centers, causing disturbed homeostatic control of cardiorespiratory and arousal responses, possibly leading to SIDS.
Kadhim
Hazim
H
Laboratoire de Neurologie du Développement, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium. Hazim.Kadhim@nepe.ucl.ac.be
Kahn
André
A
Sébire
Guillaume
G
D001111:Arcuate Nucleus of Hypothalamus / Q000473:pathology; D001921:Brain / Q000473:pathology*; D001923:Brain Chemistry; D001933:Brain Stem / Q000473:pathology; D016207:Cytokines / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D007375:Interleukin-1 / Q000032:analysis*; D015850:Interleukin-6 / Q000032:analysis; D008297:Male; D009474:Neurons / Q000473:pathology; D009929:Organ Size; D013398:Sudden Infant Death / Q000209:etiology / Q000473:pathology*; D013577:Syndrome; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha