title: Oral administration of Agaricus blazei (H1 strain) inhibited tumor growth in a sarcoma 180 inoculation model.
abstract: Agaricus blazei (H1 strain) was tested for its anticancer activity using a sarcoma 180 (S180) inoculation model and the changing patterns of splenocyte subsets were examined. Its hot-water extract was administered orally to ICR and KSN nude mice that were inoculated with S180. The growth of S180 was significantly inhibited in A.blazei treated groups. Pan T cells significantly increased in all treated groups compared to controls, even in KSN nude mice. Splenocyte subset changes were slightly different between ICR and KSN nude mice. This S180 inoculation model proved to be effective in screening the antitumor effect of basidiomycetes and allowed comparisons of immunological cellular changes between the mouse strains.
authors: Department of Physiology, College of Medicine, Hallym University, Chunchun, Korea.
authors: Yun-Lyul
authors: YL
authors: Lee
authors: Heui-Jin
authors: HJ
authors: Kim
authors: Mi-Sook
authors: MS
authors: Lee
authors: Ji-Min
authors: JM
authors: Kim
authors: Jin-Soo
authors: JS
authors: Han
authors: Euk-Ki
authors: EK
authors: Hong
authors: Myung-Sang
authors: MS
authors: Kwon
authors: Min-Jae
authors: MJ
authors: Lee
mesh_terms: D000284:Administration, Oral; D000364:Agaricus; D000818:Animals; D004195:Disease Models, Animal; D016131:Lymphocyte Subsets; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage*; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D013154:Spleen / Q000276:immunology; D014867:Water
chemical_list: D010936:Plant Extracts; D014867:Water