A new method for quantifying encephalization in the growing individual.
Here we describe a new method for quantifying encephalization in the growing individual and provide a worked example of the methods. The new method is based on the use of conditional SD scores derived from brain and body growth references. These encephalization SD scores control for age, sex and body size effects on brain size, and therefore, control for the confounds associated with allometry as well as growth differences between the brain and body and between the sexes. The methods also control for distribution skewness. Encephalization SD scores derived from pre- and post-natal data may be directly compared and changes in SD score over time assessed. These methods may be applied to a broad range of data where relative size during growth is to be quantified. Derived SD scores may also be applied to correlation and regression analyses where statistical relationships with other variables are of interest.
Joffe
Tracey H
TH
Institute of Child Health, MRC Childhood Nutrition Research Centre, 30 Guilford Street, London WC1N 1EH, UK. tracey.joffe@tufts.edu
Cole
Timothy J
TJ
Wells
Jonathan C K
JC
Geary
Michael P
MP
Rodeck
Charles H
CH
Hindmarsh
Peter C
PC
D000375:Aging / Q000502:physiology*; D001824:Body Constitution; D001921:Brain / Q000254:growth & development*; D002648:Child; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D005260:Female; D005783:Gender Identity; D006801:Humans; D007223:Infant; D008297:Male; D008954:Models, Biological; D015233:Models, Statistical