[A new method of establishing adult rat model of skin necrosis].
A new method of establishing adult rat model of skin necrosis using L-arginine (L-ARG) is described. The adult rats were subjected to 5 to 7-day treatment with L-ARG at the dose of 500 mg/kg.b.w.d that was dissolved in the drinking water, and skin necrosis was subsequently observed in approximately 50% of the rats. Using L-ARG is simple and efficient to establish animal models of skin necrosis, yielding a high success rate within a relatively shorter period of time.
Yin
Yan-Ru
YR
Department of Physiology, Branch Campus of First Military Medical University, Guangzhou 510315, China. yyr6454@163.com
Bai
Lin
L
D000818:Animals; D001120:Arginine / Q000633:toxicity; D008297:Male; D023421:Models, Animal; D009336:Necrosis; D009569:Nitric Oxide / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000473:pathology*
D009569:Nitric Oxide; D001120:Arginine