title: [NT-proBNP and atrioventricular plane displacement. Relationship and diagnostic implications].
abstract: OBJECTIVE
  NT-proBNP is useful in the diagnosis of heart failure and ventricular dysfunction. Left atrioventricular plane displacement (AVPD) is a consolidated index of ventricular function. Our objective was to carry out a multicenter population-based study to establish the relationship between plasma NT-proBNP levels with AVPD values.
  
  
  METHODS
  We studied 215 subjects (age 66 9 years; 57.7% women) chosen from a random sample of 432 people from the Community of Valencia, who previously reported suffering from some degree of dyspnea. Doppler echocardiography was done, AVPD was calculated and plasma NT-proBNP concentrations were determined. All studies were completed in 194 patients.
  
  
  RESULTS
  For the whole population NT-proBNP was 88 (0-2,586) pg/ml and AVPD was 11.9 1.6 mm. NT-proBNP concentration correlated well with AVPD (r = 0.44; p < 0.00001), and higher peptide levels were obtained in AVPD quartiles that indicated less displacement (p < 0.05). When NT-proBNP values were grouped according to their association with AVPD lower or higher than the 50th percentile AVPD, the difference was significant at p < 0.01. When AVPD values lower and higher than 10 mm were compared, NT-proBNP values were higher in persons with AVPD lower than 10 mm (p < 0.05).
  
  
  CONCLUSIONS
  This population study found higher NT-proBNP concentrations in subjects with lower AVPD, and illustrates the potential diagnostic usefulness of NT-proBNP in clinical practice.
authors: Centro de Investigación. Hospital La Fe. Valencia. España. rivera_jmi@gva.es
authors: Miguel
authors: M
authors: Rivera
authors: Raquel
authors: R
authors: Cortés
authors: Vicente
authors: V
authors: Mora
authors: Vicente
authors: V
authors: Miró
authors: Juan
authors: J
authors: Cosín
authors: Alejandro
authors: A
authors: Jordán
authors: Fernando
authors: F
authors: García de Burgos
authors: Antonio
authors: A
authors: Salvador
authors: Francisco
authors: F
authors: Sogorb
authors: Francisco
authors: F
authors: Marín
authors: Vicente
authors: V
authors: Climent
authors: Vicente
authors: V
authors: Bertomeu
authors: Araceli
authors: A
authors: Frutos
authors: Raquel
authors: R
authors: Taléns
authors: Rafael
authors: R
authors: Payá
authors: José L
authors: JL
authors: Pérez Boscá
authors: José L
authors: JL
authors: Diago
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D018618:Echocardiography, Doppler, Color; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain; D009419:Nerve Tissue Proteins / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011498:Protein Precursors / Q000097:blood*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000097:blood* / Q000000981:diagnostic imaging
chemical_list: D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D011498:Protein Precursors; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain