title: Sialylated endogenous glycoconjugates in plant cells.
abstract: Bioengineered plants are emerging as promising systems for the production of therapeutically valuable proteins. It has been commonly accepted that plants do not perform mammalian-like post-translational modifications, particularly sialylation of glycoconjugates, and no evidence has previously been reported to suggest that they have such capabilities. Here we report the presence of sialylated glycoconjugates in suspension-cultured cells of Arabidopsis thaliana and suggest that a genetic and enzymatic basis for sialylation exists in plants.
authors: Harrington Department of Bioengineering and Arizona BioDesign Institute, Arizona State University, PO Box 879709, Tempe, Arizona 85287-9709, USA.
authors: Miti M
authors: MM
authors: Shah
authors: Kazuhito
authors: K
authors: Fujiyama
authors: C Robert
authors: CR
authors: Flynn
authors: Lokesh
authors: L
authors: Joshi
mesh_terms: D017360:Arabidopsis / Q000378:metabolism*; D001212:Asialoglycoproteins / Q000032:analysis* / Q000378:metabolism*; D006001:Glycoconjugates / Q000032:analysis* / Q000378:metabolism*; D006031:Glycosylation; D019158:N-Acetylneuraminic Acid / Q000032:analysis* / Q000378:metabolism*
chemical_list: D001212:Asialoglycoproteins; D006001:Glycoconjugates; D019158:N-Acetylneuraminic Acid