title: Performance of hydroxyapatite bone repair scaffolds created via three-dimensional fabrication techniques.
abstract: The current study analyzes the in vivo performance of porous sintered hydroxyapatite (HA) bone repair scaffolds fabricated using the TheriForm solid freeform fabrication process. Porous HA scaffolds with engineered macroscopic channels had a significantly higher percentage of new bone area compared with porous HA scaffolds without channels in a rabbit calvarial defect model at an 8-week time point. An unexpected finding was the unusually large amount of new bone within the base material structure, which contained pores less than 20 microm in size. Compared with composite scaffolds of 80% polylactic-co-glycolic acid and 20% beta-tricalcium phosphate with the same macroscopic architecture as evaluated in a previous study, the porous HA scaffolds with channels had a significantly higher percentage of new bone area. Therefore, the current study indicates that scaffold geometry, as determined by the fabrication process, can enhance the ability of a ceramic material to accelerate healing of calvarial defects.
authors: Departtment of Orthopaedics, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, MSB G-574, Newark, New Jersey 07103, USA.
authors: Tithi
authors: T
authors: Dutta Roy
authors: Joshua L
authors: JL
authors: Simon
authors: John L
authors: JL
authors: Ricci
authors: E Dianne
authors: ED
authors: Rekow
authors: Van P
authors: VP
authors: Thompson
authors: J Russell
authors: JR
authors: Parsons
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000737:chemistry* / Q000378:metabolism; D002130:Calcium Phosphates / Q000737:chemistry / Q000378:metabolism; D006882:Hydroxyapatites / Q000737:chemistry* / Q000378:metabolism; D020007:Implants, Experimental; D019344:Lactic Acid / Q000737:chemistry / Q000378:metabolism; D008297:Male; D008422:Materials Testing; D016348:Osseointegration; D011100:Polyglycolic Acid / Q000737:chemistry / Q000378:metabolism; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry / Q000378:metabolism; D011817:Rabbits; D012886:Skull / Q000166:cytology / Q000473:pathology / Q000601:surgery; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D006882:Hydroxyapatites; D011108:Polymers; C485817:beta-tricalcium phosphate; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid