title: Antioxidant and memory enhancing effects of purple sweet potato anthocyanin and cordyceps mushroom extract.
abstract: The effects of purple sweet potato anthocyanin (SPA) and Cordyceps mushroom extract (CME) on lipid peroxidation, 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and cognitive deficits were examined. Both SPA and CME exhibited DPPH radical scavenging activities with similar potency. In contrast, only SPA was shown to effectively inhibit lipid peroxidation initiated by Fe2+ and ascorbic acid in rat brain homogenates. Furthermore, SPA markedly enhanced cognitive performance, assessed by passive avoidance test in ethanol-treated mice. Combined treatments with SPA and CME did not significantly influence the effects of SPA alone. These results demonstrate that anthocyanin prepared from purple sweet potato exhibits memory enhancing effects, which may be associated with its antioxidant properties.
authors: College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea.
authors: Jungsook
authors: J
authors: Cho
authors: Jong Seong
authors: JS
authors: Kang
authors: Pham Hoai
authors: PH
authors: Long
authors: Jhang
authors: J
authors: Jing
authors: Yiho
authors: Y
authors: Back
authors: Kyeong-Soo
authors: KS
authors: Chung
mesh_terms: D000284:Administration, Oral; D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D000872:Anthocyanins / Q000032:analysis / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001713:Biphenyl Compounds; D001921:Brain / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D003072:Cognition Disorders / Q000188:drug therapy / Q000209:etiology; D045424:Complex Mixtures / Q000737:chemistry; D032661:Cordyceps / Q000302:isolation & purification; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects / Q000037:antagonists & inhibitors; D016166:Free Radical Scavengers / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000737:chemistry / Q000378:metabolism; D027723:Ipomoea batatas / Q000737:chemistry*; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008297:Male; D008569:Memory Disorders / Q000517:prevention & control*; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D010851:Picrates / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D001713:Biphenyl Compounds; D045424:Complex Mixtures; D016166:Free Radical Scavengers; D010851:Picrates; D010936:Plant Extracts; D017665:Hydroxyl Radical; D000431:Ethanol; C004931:1,1-diphenyl-2-picrylhydrazyl