Oxidant/antioxidant status in patients with recurrent aphthous stomatitis.
Recurrent aphthous stomatitis (RAS) is recognized as one of the most common oral mucosal diseases worldwide. The aim of this study was to determine the oxidant/antioxidant status in erythrocyte and plasma samples from patients with RAS in comparison with healthy controls. Twenty-two patients with RAS and 23 healthy controls were recruited. Superoxide dismutase, glutathione peroxidase (GSHPx) and catalase (CAT) activities, and malondialdehyde (MDA) and antioxidant potential (AOP) levels were measured in plasma and erythrocytes from patient with RAS and controls. We found decreased CAT and GSHPx activities and AOP levels in the erythrocytes, and decreased AOP and increased MDA plasma levels in patients with RAS in comparison with control subjects. In summary, this study demonstrated that enzymatic and nonenzymatic antioxidant defence systems are impaired in patients with RAS.
Cimen
M Y B
MY
Department of Biochemistry, School of Medicine, Mersin University, Mersin, Turkey. mybcimen@mersin.edu.tr
Kaya
T I
TI
Eskandari
G
G
Tursen
U
U
Ikizoglu
G
G
Atik
U
U
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000627:therapeutic use; D002374:Catalase / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D016877:Oxidants / Q000097:blood*; D011446:Prospective Studies; D012008:Recurrence; D012643:Selenium / Q000627:therapeutic use; D013281:Stomatitis, Aphthous / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000097:blood
D000975:Antioxidants; D016877:Oxidants; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium; D001205:Ascorbic Acid