Comparison of induction and recovery characteristics of intravenous midazolam and thiopentone in paediatric halothane general anaesthesia.
Fifty children were randomized for induction with 0.3 mg kg(-1) midazolam or 5 mg kg(-1) thiopentone. Efficacy, safety, recovery time, amnesic effect, tolerability and recovery characteristics were compared. Midazolam required longer for induction and recovery from anaesthesia. The safety profile was similar with both drugs.


CONCLUSIONS
Midazolam is efficacious and safe for the induction of anaesthesia in children. Its action is comparable with thiopentone and may be an alternative to it.
Mathew
P J
PJ
Department of Anaesthesia and Critical Care, Jawahar Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Ravishankar
M
M
Badhe
A
A
Hemavathy
B
B
Mathew
J L
JL
D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D018686:Anesthetics, Intravenous; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008874:Midazolam; D011597:Psychomotor Performance; D013874:Thiopental
D018686:Anesthetics, Intravenous; D013874:Thiopental; D008874:Midazolam