title: Effects of anabolic steroids and antioxidant vitamins on ethanol-induced tissue injury.
abstract: Various mechanisms are involved in the process of ethanol-induced tissue impairment. Oxidative stress and its effects are among the most important. We compared the effects of antioxidant vitamins (vitamin C and E in combination) and steroids (testosterone and nandrolone separately) on the toxicity of ethanol in rats. Animals (male Wistar rats, n = 48) were randomised into following groups-Control, Ethanol, Testosterone, Ethanol + Testosterone, Ethanol + Nandrolone, Ethanol + Vitamins. Alcohol was given daily by gavage in a dose of 5 g/kg of body weight. On the 27th day of the study the animals were sacrificed by decapitation and tissue samples were taken. Metabolic status, parameters of the hepatic metabolism, hormone levels (testosterone, ACTH, corticosterone), lipoperoxidation markers (malondialdehyde and conjugated diens in forebrain cortex and in cerebellum) and advanced glycation end-products were analysed. Tissue samples underwent histological examination. Histological outcomes showed a protective effect of antioxidants on hepatic and cerebellar injury caused by chronic ethanol intake. Anabolic steroids protected especially the central nervous tissue against the toxicity of alcohol. Both, antioxidant vitamins and anabolic steroids protect against the ethanol-induced toxicity, however, this effect is tissue specific.
authors: Faculty of Medicine, Georg-August University, Göttingen, Germany. petercelec@hotmail.com
authors: Peter
authors: P
authors: Celec
authors: Peter
authors: P
authors: Jáni
authors: Lucia
authors: L
authors: Smreková
authors: Andrej
authors: A
authors: Mrlian
authors: Matús
authors: M
authors: Kúdela
authors: Július
authors: J
authors: Hodosy
authors: Peter
authors: P
authors: Boor
authors: Viera
authors: V
authors: Kristová
authors: Ján
authors: J
authors: Jakubovský
authors: Daniela
authors: D
authors: Jezová
authors: Lukác
authors: L
authors: Halcák
authors: Peter
authors: P
authors: Bozek
authors: Judita
authors: J
authors: Slámová
authors: Ol'ga
authors: O
authors: Ulicná
authors: Dalibor
authors: D
authors: Hojsík
authors: Ingrid
authors: I
authors: Jurkovicová
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D045930:Anabolic Agents / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D002452:Cell Count; D002492:Central Nervous System Depressants / Q000633:toxicity*; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000517:prevention & control; D003345:Corticosterone / Q000097:blood; D004357:Drug Synergism; D042783:Endothelial Cells / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009277:Nandrolone / Q000494:pharmacology; D009420:Nervous System / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D011689:Purkinje Cells / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000378:metabolism; D013256:Steroids / Q000494:pharmacology*; D013739:Testosterone / Q000097:blood / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D045930:Anabolic Agents; D000975:Antioxidants; D002492:Central Nervous System Depressants; D012709:Serum Albumin; D013256:Steroids; D014280:Triglycerides; D014810:Vitamin E; D000431:Ethanol; D013739:Testosterone; D008315:Malondialdehyde; D009277:Nandrolone; D000324:Adrenocorticotropic Hormone; D001205:Ascorbic Acid; D003345:Corticosterone