The polycythaemia rubra vera-1 gene is constitutively expressed by bone marrow cells and does not discriminate polycythaemia vera from reactive and other chronic myeloproliferative disorders.
Little is known about the expression of the polycythaemia rubra vera-1 (PRV-1) gene in bone marrow cells. To determine the expression level of PRV-1 in the bone marrow, we analysed PRV-1 quantitatively in Polycythaemia vera, other chronic myeloproliferative disorders, and reactive states. We demonstrated that PRV-1 was constitutively expressed in both myeloproliferative and reactive states. We concluded that, rather than an upregulation of the PRV-1 gene in the clonal haematopoiesis of polycythaemia vera, a failure to downregulate PRV-1 in granulocytes emigrating from the bone marrow might be responsible for the increase of transcripts in peripheral cells.
Bock
Oliver
O
Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany. Bock.Oliver@MH-Hannover.de
Serinsöz
Ebru
E
Neusch
Michael
M
Schlué
Jerome
J
Kreipe
Hans
H
D001854:Bone Marrow Cells / Q000378:metabolism*; D058851:GPI-Linked Proteins; D015870:Gene Expression; D005819:Genetic Markers; D006098:Granulocytes / Q000378:metabolism; D006410:Hematopoiesis / Q000235:genetics; D006801:Humans; D007519:Isoantigens; D008562:Membrane Glycoproteins; D009196:Myeloproliferative Disorders / Q000378:metabolism; D011087:Polycythemia Vera / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
C407242:CD177 protein, human; D058851:GPI-Linked Proteins; D005819:Genetic Markers; D007519:Isoantigens; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface