Human seminal plasma antibody-binding proteins.
OBJECTIVE
The physiological role of antibody-binding proteins in human seminal plasma and the potential role of these proteins in infertility is relatively unknown.


METHODS
Literature on antibody-binding proteins.


RESULTS
Human seminal plasma has a diverse effect on immune function of the reproductive tracts. This review describes (1) the presence of receptors like proteins that can react with monoclonal antibodies against Fcgamma receptors III (Fcgamma RIII) but are distinctly different from Fcgamma RIII; (2) IgG binding factors (IgGBF), a group of low molecular weight proteins that are capable of binding human IgG; (3) other proteins that can bind antibodies, such as prolactin-inducible protein and three other novel proteins that we have discovered. These proteins potentially all have the ability to reduce the interactions between antisperm antibodies and effector components of the immune system, such as phagocytic cells.


CONCLUSIONS
Human seminal plasma contains proteins that can bind antibodies. However, to date our knowledge of these proteins especially, whether they have a physiological role in either the male and female reproductive tracts is limited.
Chiu
W W C
WW
Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand. will.chiu@auckland.ac.nz
Chamley
L W
LW
D000906:Antibodies / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D008222:Lymphokines / Q000378:metabolism*; D008297:Male; D029584:Prostatic Secretory Proteins; D017452:Receptors, IgG / Q000276:immunology / Q000378:metabolism*; D012661:Semen / Q000276:immunology*; D013094:Spermatozoa / Q000276:immunology
D000906:Antibodies; D008222:Lymphokines; D029584:Prostatic Secretory Proteins; D017452:Receptors, IgG; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors