Dosage of OKT3 independent of body weight: a mistake?
Comparing OKT3 and antithymocyte globulin (ATG) in a prospective study, the dosage difference in regard to body weight (ATG: dependent on body weight/OKT3: independent) does not introduce any obvious source of mistake concerning clinical effectiveness or side effects. One explanation for the lack of influence of body weight may be the high effectiveness of 5 mg of OKT3, reaching a maximal effect even with lower plasma levels in heavier patients. We wonder, therefore, whether the OKT3 dosage could be lowered.
Bachofen
M
M
Division of Nephrology, Department of Internal Medicine and Surgery, University of Basel, Basel, Switzerland.
Gallati
H
H
Pracht
I
I
Bock
H
H
Landmann
J
J
Thiel
G
G
D000818:Animals; D000910:Antibodies, Heterophile / Q000097:blood; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001835:Body Weight / Q000502:physiology*; D017252:CD3 Complex / Q000097:blood; D003404:Creatinine / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000276:immunology*; D018655:Lymphocyte Count; D008775:Methylprednisolone / Q000627:therapeutic use; D016853:Muromonab-CD3 / Q000008:administration & dosage* / Q000627:therapeutic use; D011817:Rabbits; D015203:Reproducibility of Results
D000910:Antibodies, Heterophile; D000961:Antilymphocyte Serum; D017252:CD3 Complex; D007166:Immunosuppressive Agents; D016853:Muromonab-CD3; D003404:Creatinine; D008775:Methylprednisolone