title: [Long-term outcome of advanced hepatocellular carcinoma that received transarterial hepatic chemotherapy].
abstract: Nineteen patients with far advanced hepatocellular carcinoma received transarterial hepatic chemotherapy. Twelve patients were Child-Pugh A, 2 were B, and 2 were C. Seventeen patients had portal vein thrombus, and 2 patients had extra-hepatic metastasis. Among the 19 patients, 13 received low-dose CDDP and 5-FU, and 5-FU with interferon was performed in 2. Lipiodol chemotherapy with epirubicin and MMC was performed after first-line chemotherapy, following the evaluation of the progressive disease. The 1- and 3-year survival rates in all cases were 42.5% and 18.2%, respectively. Of the 18 patients evaluated for response, 1 showed complete response, 2 showed partial responses, 8 had stable disease, and 7 progressed. Median survival time of CR, PR and SD patients was 14.2 months. A multivariate analysis identified CLIP score and therapeutic effect as independent predictors for mortality. It is concluded that transarterial hepatic chemotherapy was very useful for far advanced hepatocellular carcinoma.
authors: Dept. of Surgery, Sakai City Hospital.
authors: Seizo
authors: S
authors: Masutani
authors: Junzo
authors: J
authors: Shimizu
authors: Masayuki
authors: M
authors: Tatsuta
authors: Fumikazu
authors: F
authors: Masuda
authors: Hiroshi
authors: H
authors: Imamura
authors: Hideyuki
authors: H
authors: Ishida
authors: Hiroshi
authors: H
authors: Furukawa
authors: Kouichi
authors: K
authors: Tomotsu
authors: Mamoru
authors: M
authors: Yura
authors: Takashi
authors: T
authors: Obana
authors: Shinji
authors: S
authors: Kitamura
authors: Naoya
authors: N
authors: Saeki
authors: Yutaka
authors: Y
authors: Inoue
authors: Manabu
authors: M
authors: Takamura
authors: Hiromitsu
authors: H
authors: Ohnishi
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D011379:Prognosis; D015996:Survival Rate; D013927:Thrombosis / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin; D005472:Fluorouracil