Preparation and spectral investigation on inclusion complex of beta-cyclodextrin with rutin.
Solid inclusion complex of rutin with beta-cyclodextrin (beta-CD) was prepared by coprecipitate method. The formation of inclusion complex was confirmed by differential scanning calorimetry (DSC) and X-ray diffraction. The formation constant was obtained by steady-state fluorescence measurements and the result suggested the complex preferred 1:1 (rutin:CD) stoichiometry. Furthermore, the spatial configuration of the complex has been proposed based on NMR and molecular modeling.
Haiyun
Ding
D
Department of Chemistry, Shanxi University, Taiyuan 030006, China.
Jianbin
Chao
C
Guomei
Zhang
Z
Shaomin
Shuang
S
Jinhao
Pan
P
D003505:Cyclodextrins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D012431:Rutin / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D012431:Rutin; C031215:betadex