In vitro effects of pentifin on some neurotransmitter systems in the brain.
Pentifin and dopamine D1 receptor antagonist SCH-23390 possess similar pharmacological properties. In the present work we studied in vitro effects of Pentifin on dopamine receptors. Experiments on rat ductus deferents showed that Pentifin acts as a weak ligand of dopamine receptors. Our results indicate that the antihaloperidol effect of Pentifin is not related to the blockade of dopamine receptors.
Gorbatova
E N
EN
State Institute of Organic Chemistry and Technology, Moscow. dir@GosNIIOKhT.rmt.ru
Dagaev
S G
SG
Dolgo-Saburov
V B
VB
Dukhovich
F S
FS
D000605:Amino Alcohols / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D003517:Cyclopentanes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D010300:Parkinson Disease / Q000188:drug therapy; D010880:Piperidines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism*; D012669:Seminal Vesicles / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
D000605:Amino Alcohols; D003517:Cyclopentanes; D018492:Dopamine Antagonists; D018377:Neurotransmitter Agents; D010880:Piperidines; D011954:Receptors, Dopamine; C492521:pentifin