title: Rho GTPases and cadherin-based cell adhesion in skeletal muscle development.
abstract: The small GTPases of the Rho subfamily (RhoA, Rac1 and Cdc42) are signaling molecules involved in cytoskeleton remodeling and gene transcription. Their activities are important for many cellular processes, including myogenesis. Classical cadherin adhesion molecules are key determinants of cell recognition and tissus morphogenesis and act as adhesion-activated signaling receptors. Rho GTPases have emerged as key mediators of their activity. Not only signal transduction pathways link cadherins to Rho GTPases but also Rho GTPases to cadherins. We focus in this review on the role of cadherins and Rho GTPases in normal myogenesis as well as in pathological development of rhabdomyosarcoma.
authors: CRBM-CNRS, 1919 Route de Mende, 34293 Montpellier Cedex, France.
authors: Sophie
authors: S
authors: Charrasse
authors: Marie
authors: M
authors: Causeret
authors: Franck
authors: F
authors: Comunale
authors: Armelle
authors: A
authors: Bonet-Kerrache
authors: Cécile
authors: C
authors: Gauthier-Rouvière
mesh_terms: D000818:Animals; D015820:Cadherins / Q000737:chemistry / Q000378:metabolism*; D002448:Cell Adhesion / Q000502:physiology; D006801:Humans; D018482:Muscle, Skeletal / Q000166:cytology / Q000254:growth & development / Q000378:metabolism*; D020741:rho GTP-Binding Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D015820:Cadherins; D020741:rho GTP-Binding Proteins