Early kidney transplantation may prevent aluminium-related bone disease.
In uraemia patients aluminium (Al) accumulation in bone leads to low turn-over bone disease. Al-related bone disease causes bone pain, non-traumatic fractures and hypercalcaemia, and does not respond to treatment with vitamin D compounds. Al-contaminated dialysate and ingestion of Al-containing phosphate binding agents are the main risk factors for bone Al accumulation. Studies of selected patients have indicated that Al-related bone disease ameliorates after successful kidney transplantation, but systematic studies of bone Al have not been reported. In a prospective study we investigated the effect of successful kidney transplantation on bone Al and clinical bone disease.
Nordal
K P
KP
Department of Medicine, The National Hospital, Rikshospitalet, Oslo, Norway.
Dahl
E
E
Halse
J
J
Flatmark
A
A
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000535:Aluminum / Q000493:pharmacokinetics* / Q000633:toxicity*; D001706:Biopsy; D001847:Bone Diseases / Q000139:chemically induced / Q000517:prevention & control*; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000401:mortality / Q000473:pathology / Q000502:physiology*; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003404:Creatinine; D000535:Aluminum