title: Haplotype mapping of the bronchiolitis susceptibility locus near IL8.
abstract: Susceptibility to viral bronchiolitis, the commonest cause of infant admissions to hospital in the industrialised world, is associated with polymorphism at the IL8 locus. Here we map the genomic boundaries of the disease association by case-control analysis and TDT in 580 affected UK infants. Markers for association mapping were chosen after determining patterns of linkage disequilibrium across the surrounding region of chromosome 4q, a 550-kb segment containing nine genes, extending from AFP to PPBP. The region has three major clusters of high linkage disequilibrium and is notable for its low haplotypic diversity. We exclude adjacent chemokine genes as the cause of the association, and identify a disease-associated haplotype that spans a 250-kb region from AFM to IL8. In between these two genes there is only one structural feature of interest, a novel gene RASSF6, which is predicted to encode a Ras effector protein.
authors: University Department of Paediatrics, Level 4, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK. Jeremy.hull@paediatrics.ox.ac.uk
authors: Jeremy
authors: J
authors: Hull
authors: Kate
authors: K
authors: Rowlands
authors: Elizabeth
authors: E
authors: Lockhart
authors: Mike
authors: M
authors: Sharland
authors: Catrin
authors: C
authors: Moore
authors: Neil
authors: N
authors: Hanchard
authors: Dominic P
authors: DP
authors: Kwiatkowski
mesh_terms: D001483:Base Sequence; D001990:Bronchiolitis, Viral / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D005787:Gene Frequency; D005796:Genes; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007223:Infant; D016209:Interleukin-8 / Q000235:genetics*; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D018357:Respiratory Syncytial Virus Infections / Q000175:diagnosis; D006113:United Kingdom; D044465:White People / Q000235:genetics
chemical_list: D005819:Genetic Markers; D016209:Interleukin-8