[Invasiveness and cytopathogenicity of Helicobacter pylori in human cell culture].
Invasive and cytopathogenic properties of clinical strains of Helicobacter pylori in the cell culture Hep-2 have been studied. It has been established that H. pylori possesses high invasive and adhesive capacity. It has been shown that H. pylori takes considerable effect on the indices of mitotic activity, such as mitotic index (MI), level of pathogenic mitoses; it also stimulates the appearance of pathologies connected with the disturbance of mitotic apparatus and damage of chromosomes. H. pylori in the cell culture Hep-2 was observed to evoke a tendency to neoplastic growth, loss of contact inhibition, resulting in the cells piling up on each other with formation of the transformation loci.
Konareva
O P
OP
Odessa National University, Department of Microbiology and Virology, Dvoryanskaya St., Odessa, 65026, Ukraine.
Ivanitsa
V A
VA
D001422:Bacterial Adhesion; D016923:Cell Death; D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D016480:Helicobacter pylori / Q000254:growth & development / Q000472:pathogenicity*; D006801:Humans; D008940:Mitotic Index; D013997:Time Factors