Detection of serum anti-Helicobacter pylori immunoglobulin G in patients with different digestive malignant tumors.
OBJECTIVE
To investigate the seroprevalence of Helicobacter pylori infection in patients with different digestive malignant tumors.


METHODS
Enzyme linked immunosorbent assay (ELISA) was used to detect serum anti-Helicobacter pylori IgG antibody in 374 patients with different digestive malignant tumors and 310 healthy subjects (normal control group).


RESULTS
The seroprevalence of Helicobacter pylori infection was 61.50% (230/374) and 46.77% (145/310), respectively, in patients with digestive tumors and normal controls (P<0.05). The seroprevalence was 52.38% (33/63), 86.60% (84/97), 83.14% (84/101), 45.24 (19/42), 51.13% (18/35) and 44.44% (16/36), respectively in patients with carcinomas of esophagus, stomach, duodenum, rectum, colon and liver (P<0.01). In patients with intestinal and diffuse type gastric cancers, the seroprevalence was 93.75% (60/64) and 72.73% (24/33), respectively (P<0.05). In patients with gastric antral and cardiac cancers, the seroprevalence was 96.43% (54/56) and 73.17% (30/41), respectively (P<0.05). In patients with ulcerous and proliferous type duodenal cancers, the seroprevalence of H pylori infection was 91.04% (61/67) and 52.27% (23/44), respectively (P<0.05). In patients with duodenal bulb and descending cancers, the seroprevalence was 94.20% (65/69) and 45.20% (19/42), respectively (P<0.05).


CONCLUSIONS
H pylori infection is associated with occurrence and development of gastric and duodenal carcinomas. Furthermore, it is also associated with histological type and locations of gastric and duodenal carcinomas.
Wang
Ke-Xia
KX
School of Medicine, Anhui University of Science and Technology, Huainan, 232001, Anhui Province, China.
Wang
Xue-Feng
XF
Peng
Jiang-Long
JL
Cui
Yu-Bao
YB
Wang
Jian
J
Li
Chao-Pin
CP
D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D004379:Duodenal Neoplasms / Q000453:epidemiology* / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000382:microbiology
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G