Verapamil (VP) improves the outcome after renal transplantation (CRT).
Calcium antagonists (CATs) have a role in the management of certain types of renal insufficiency. These include prophylaxis against post-transplant-associated acute renal failure and cyclosporine A (CsA)-induced renal dysfunction. For the transplanted kidney, CATs may be beneficial in several settings. First, a CAT during organ procurement protects the kidney during ischemic periods. Second, CATs given perioperatively protect the kidney during reperfusion and early after transplantation. Third, CATs also offer protection against CsA nephrotoxicity.
Dawidson
I
I
U.T. Southwestern Med. Ctr., Dallas, Texas 75235, USA.
Lu
C
C
Palmer
B
B
Peters
P
P
Rooth
P
P
Risser
R
R
Sagalowsky
A
A
Sandor
Z
Z
D002121:Calcium Channel Blockers / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000097:blood / Q000627:therapeutic use / Q000633:toxicity; D005919:Glomerular Filtration Rate; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007511:Ischemia / Q000517:prevention & control; D016030:Kidney Transplantation / Q000473:pathology / Q000502:physiology*; D011446:Prospective Studies; D012189:Retrospective Studies; D013997:Time Factors; D020858:Tissue and Organ Harvesting; D016896:Treatment Outcome; D014700:Verapamil / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003404:Creatinine; D014700:Verapamil