Synthesis of poly(epsilon-caprolactone)-b-poly(gamma-benzyl-L-glutamic acid) block copolymer using amino organic calcium catalyst.
A biodegradable two block copolymer, poly(epsilon-caprolactone)-b- poly(gamma-benzyl-L-glutamic acid) (PCL-PBLG) was synthesized successfully by ring-opening polymerization of N-carboxyanhydride of gamma-benzyl-L-glutamate (BLG-NCA) with aminophenyl-terminated PCL as a macroinitiator. The aminophenethoxyl-terminated PCL was prepared via hydrogenation of a 4-nitrophenethoxyl-terminated PCL, which was novelly obtained from the polymerization of epsilon-caprolactone (CL) initiated by amino calcium 4-nitrobenzoxide. The structures of the block copolymer and its precursors from the initial step of PCL were confirmed and investigated by 1H NMR, FT-IR, GPC, and FT-ICRMS analyses and DSC measurements.
Rong
Guangzhuo
G
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
Deng
Mingxiao
M
Deng
Chao
C
Tang
Zhaohui
Z
Piao
Longhai
L
Chen
Xuesi
X
Jing
Xiabin
X
D001672:Biocompatible Materials / Q000138:chemical synthesis; D001673:Biodegradation, Environmental; D002118:Calcium; D002384:Catalysis; D015394:Molecular Structure; D011091:Polyesters / Q000138:chemical synthesis*; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D013057:Spectrum Analysis
D001672:Biocompatible Materials; D011091:Polyesters; C016240:polycaprolactone; C003172:poly-gamma-benzyl-L-glutamate; D011099:Polyglutamic Acid; D002118:Calcium