title: Plasma levels of proadrenomedullin N-terminal 20 peptide and adrenomedullin in patients undergoing hemodialysis.
abstract: BACKGROUND
  Proadrenomedullin N-terminal 20 peptide (PAMP) is a novel hypotensive peptide present in the precursor of adrenomedullin (AM), a vasodilative and natriuretic peptide. However, the profile of PAMP in hemodialyzed (HD) patients has not been determined.
  
  
  METHODS
  We measured plasma levels of PAMP, total AM (tAM) and a mature form of AM (mAM, the biologically active form) in HD patients (n = 31) and in normal controls (n = 21).
  
  
  RESULTS
  Plasma concentrations of PAMP before HD were significantly higher than those in controls (4.02 +/- 0.24 vs. 1.64 +/- 0.12 fmol/ml, p < 0.001) and decreased to the control level after HD (2.17 +/- 0.18 vs. 1.64 +/- 0.12 fmol/ml; NS). The plasma PAMP level before HD significantly correlated with weight gain during HD sessions (r = 0.41, p < 0.05), but not with predialysis blood pressure. The concentrations of mAM before and after HD were significantly higher than those in controls. The plasma mAM level before HD significantly correlated with weight gain during HD sessions, but not with predialysis blood pressure. The plasma level of PAMP did not correlate with that of mAM in HD patients.
  
  
  CONCLUSIONS
  PAMP and AM may be involved in the regulation of blood volume in patients undergoing HD.
authors: First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan.
authors: Takeshi
authors: T
authors: Tokura
authors: Hiroshi
authors: H
authors: Kinoshita
authors: Shouichi
authors: S
authors: Fujimoto
authors: Kazuo
authors: K
authors: Kitamura
authors: Tanenao
authors: T
authors: Eto
mesh_terms: D053607:Adrenomedullin / Q000031:analogs & derivatives; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D010455:Peptides / Q000097:blood*; D011506:Proteins; D006435:Renal Dialysis; D015430:Weight Gain
chemical_list: D010446:Peptide Fragments; D010455:Peptides; D011506:Proteins; C108283:proadrenomedullin (9-20); D053607:Adrenomedullin