Derivatized amino acids relevant to native peptide synthesis by chemical ligation and acyl transfer.
Three amino acids were converted into the derivatives 5.2 (from glycine), 6.4a and 6.4b (from alanine), and 8.3a and 8.3b (from O-benzyl serine). These N-alkylated amino acids, which can be deprotected after conversion of the carboxyl into an amide, correspond to the general structure 2.1, a compound class of use in the study of peptide segment coupling by the ligation-acyl transfer method.
Clive
Derrick L J
DL
Chemistry Department, University of Alberta, Edmonton, Alberta, Canada T6G 2G2. derrick.clive@ualberta.ca
Hisaindee
Soleiman
S
Coltart
Don M
DM
D000215:Acylation; D000409:Alanine / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D005998:Glycine / Q000737:chemistry; D008026:Ligation; D008956:Models, Chemical; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D012694:Serine / Q000737:chemistry
D000596:Amino Acids; D010455:Peptides; D012694:Serine; D000409:Alanine; D005998:Glycine