Antimicrobial and cytotoxicity evaluation of Buchholzia coriacea stem bark.
Fractions prepared from the methanol extract of Buchholzia coriacea stem bark exhibited a high concentration-dependent antibacterial and antifungal activity compared to the standard antibiotics, ampicillin and tioconazole. In the brine shrimp lethality (BSL) assay, the methanol extract was found to be non-toxic with an LC(50) of 1031 microg/ml. The two main compounds present in the most active fraction were isolated and identified as lupeol and beta-sitosterol.
Ajaiyeoba
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Department of Pharmacognosy, University of Ibadan, Ibadan, Nigeria. edajaiye@yahoo.com
Onocha
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Nwozo
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Sama
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D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001156:Artemia / Q000187:drug effects*; D001231:Aspergillus flavus / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D002176:Candida albicans / Q000187:drug effects; D006801:Humans; D007928:Lethal Dose 50; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D000890:Anti-Infective Agents; D010936:Plant Extracts; D014315:Triterpenes