Association of Chlamydia pneumoniae with central nervous system disease.
Chlamydia pneumoniae is a common respiratory pathogen that is now being incriminated in a number of chronic diseases. The ability of C. pneumoniae to infect and persist in macrophages makes it a likely candidate to disseminate in a number of different tissues, including those of the central nervous system. This review addresses the potential and the underlying mechanisms by which C. pneumoniae infections can play a role in such diverse neurological diseases as multiple sclerosis and Alzheimer's disease.
Stratton
Charles W
CW
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA.
Sriram
Subramaniam
S
D000544:Alzheimer Disease / Q000175:diagnosis / Q000382:microbiology; D002493:Central Nervous System Diseases / Q000175:diagnosis / Q000382:microbiology*; D002690:Chlamydia Infections / Q000175:diagnosis / Q000382:microbiology; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification*; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000175:diagnosis / Q000382:microbiology; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000382:microbiology