title: Pharmacological studies of alcohol susceptibility and brain monoamine function in stroke-prone spontaneously hypertensive rats (SHRSP) and stroke-resistant spontaneously hypertensive rats (SHRSR).
abstract: Differences of alcohol drinking behavior, brain dopamine (DA) and serotonin (5-HT) levels and releases in the striatum were investigated in stroke-prone spontaneously hypertensive rats (SHRSP) and age-matched stroke-resistant spontaneously hypertensive rats (SHRSR). Voluntary alcohol (EtOH) consumption in SHRSP rats increased at 1 and 2 hours in the 4 hour time access. In the DA level, SHRSP showed decreases in the caudate-putamen (C/P) and dorsal raphe nucleus (DRN) compared with in SHRSR. 5-HT levels in the C/P, ventral tegmental area-subtantia nigra (V/S) and DRN of the SHRSP were decreased compared with that in SHRSR. The basal extracellular levels of 5-HT release in the C/P were increased in SHRSP as compared with those in SHRSR. K(+)- or EtOH-induced DA and 5-HT releases in the C/P of the SHRSP were a lower magnitude than those in SHRSR. Increased basal extracellular 5-HT releases showing low levels of 5-HT in the C/P of SHRSP mean an abnormality of serotonergic neuronal functions in a normal physiological condition. Higher voluntary alcohol drinking behavior, so called lower susceptibility to EtOH, in the SHRSP may be associated with the degenerated rewarding system including the DRN. These results suggest that the hypertensive state causes the dysfunction in the striatum of the brain rewarding system and induces the risk for increasing alcohol consumption to compensate for the alteration of serotonergic neurons.
authors: Department of Legal Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan. kyoshimo@basic.kpu-m.ac.jp
authors: Kanji
authors: K
authors: Yoshimoto
authors: Setsuo
authors: S
authors: Komura
authors: Hiroyuki
authors: H
authors: Hattori
authors: Yukio
authors: Y
authors: Yamori
authors: Ayako
authors: A
authors: Miura
authors: Toshihide
authors: T
authors: Yoshida
authors: Chizuko
authors: C
authors: Hioki
authors: Baku
authors: B
authors: Kato
authors: Fuimihiko
authors: F
authors: Fukuda
authors: Shiho
authors: S
authors: Tanaka
authors: Ayako
authors: A
authors: Hirai
authors: Akira
authors: A
authors: Nishimura
authors: Yasuko
authors: Y
authors: Sawai
authors: Masahiro
authors: M
authors: Yasuhara
mesh_terms: D000428:Alcohol Drinking / Q000235:genetics / Q000378:metabolism; D000437:Alcoholism / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D005518:Food Preferences / Q000187:drug effects; D020022:Genetic Predisposition to Disease; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR / Q000235:genetics*; D011921:Rats, Inbred WKY; D012701:Serotonin / Q000378:metabolism; D020521:Stroke / Q000150:complications / Q000235:genetics
chemical_list: D012701:Serotonin; D000431:Ethanol; D004298:Dopamine