Isolation of bisindole alkaloids that inhibit the cell cycle from Myxomycetes Arcyria ferruginea and Tubifera casparyi.
From a myxomycete Arcyria ferruginea, dihydroarcyriarubin C (1), a new bisindole alkaloid, has been isolated together with two known bisindoles, arcyriarubin C (2) and arcyriaflavin C (3), and arcyriaflavin C (3) was also isolated from Tubifera casparyi together with arcyriaflavin B (4). Arcyriaflavin C (3) exhibited cell cycle inhibition effect at G1 and G2/M stage at 10 and 100ng/mL, respectively.
Nakatani
Satomi
S
Graduate School of Pharmaceutical Sciences, Chiba University, Japan.
Naoe
Ayano
A
Yamamoto
Yukinori
Y
Yamauchi
Tomohiro
T
Yamaguchi
Naoto
N
Ishibashi
Masami
M
D002453:Cell Cycle / Q000187:drug effects*; D004247:DNA / Q000032:analysis; D016193:G1 Phase / Q000187:drug effects; D016195:G2 Phase / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D009235:Myxomycetes / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular
D026121:Indole Alkaloids; C480778:arcyriaflavin C; D004247:DNA