Ventricular natriuretic peptide (BNP) in heart transplantation: BNP correlation with endomyocardial biopsy, laboratory and hemodynamic measures.
A prospective study of 81 heart transplant (HT) patients was carried out in order to evaluate the evolution of brain natriuretic peptide (BNP) levels in HT patients and compare them with the degree of rejection as determined by endomyocardial biopsy. All patients were subjected to endomyocardial biopsy (532), and determination of BNP and creatinine levels as well as hemodynamic parameters. A control group of 36 volunteers was included. BNP values were significantly greater in HT patients than in healthy volunteers. In the first 3 months, BNP levels in patients with treatable rejection were significantly greater than in patients without graft rejection, although evident overlapping was observed in both distributions and discriminatory potential was low. After the third month, BNP values were similar in patients with and without rejection. Creatinine levels were observed to increase over time after transplantation, but no correlation was observed between the creatinine and BNP levels. A significant positive correlation was observed between BNP and right ventricle and pulmonary arterial pressures.
Hervás
Isabel
I
Department of Nuclear Medicine, University Hospital La Fe, Valencia, Spain. iherves@unicia.es
Arnau
Miguel A
MA
Almenar
Luís
L
Pérez-Pastor
Jose L
JL
Chirivella
Melitina
M
Osca
Joaquín
J
Bello
Pilar
P
Osa
Ana
A
Martí
Jose F
JF
Vera
Francisco
F
Mateo
Antonio
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D003404:Creatinine / Q000097:blood; D004699:Endocardium / Q000378:metabolism*; D005260:Female; D006084:Graft Rejection / Q000097:blood* / Q000503:physiopathology; D016027:Heart Transplantation; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011446:Prospective Studies; D012372:ROC Curve; D012016:Reference Values; D013997:Time Factors
D020097:Natriuretic Peptide, Brain; D003404:Creatinine