title: [Glanzmann's thrombasthenia and pregnancy: a case and review of the literature].
abstract: Glanzmann's thrombasthenia is a thrombopathy due to a qualitative or quantitative abnormality of glycoproteins GP IIb-IIIa. Pregnancy is uncommon and dangerous. Delivery often results in important haemorrhage, which is treated with HLA compatible platelet and packed red blood cells transfusions. Platelet transfusion may produce antibody that render transfusions ineffective. Newborn thrombocytopenia is occasionally severe, but is always transitory. Caesarean section has no proven advantage. We report a case with caesarean, which was successfully managed by platelet transfusion over seven peripartum days, with no adverse event. Literature is discussed.
authors: Département d'anesthésie-réanimation, CHU Angers, 4, rue Larrey, 49033 Angers 01, France. chmonrigal@chu-angers.fr
authors: C
authors: C
authors: Monrigal
authors: P
authors: P
authors: Beurrier
authors: F-J
authors: FJ
authors: Mercier
authors: C
authors: C
authors: Boyer-Neumann
authors: P
authors: P
authors: Gillard
mesh_terms: D000328:Adult; D002585:Cesarean Section; D036861:Delivery, Obstetric; D017707:Erythrocyte Transfusion; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D017713:Platelet Transfusion; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000503:physiopathology*; D013915:Thrombasthenia / Q000503:physiopathology*