title: Synthesis and cytotoxicity of 5-fluorouracil/diazeniumdiolate conjugates.
abstract: 5-Fluorouracil/diazeniumdiolate conjugates were first synthesized, and showed greater cytotoxicities than 5-fluorouracil for DU 145 human prostate and HeLa cancer cells.
authors: Departments of Biochemistry and Chemistry, The Ohio State University, OH 43210, USA. pgwang@chemistry.ohio-state.edu
authors: Tingwei Bill
authors: TB
authors: Cai
authors: Xiaoping
authors: X
authors: Tang
authors: Janet
authors: J
authors: Nagorski
authors: Paul G
authors: PG
authors: Brauschweiger
authors: Peng George
authors: PG
authors: Wang
mesh_terms: D001391:Azo Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D005472:Fluorouracil / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008297:Male
chemical_list: D001391:Azo Compounds; C452539:diazeniumdiolate; D005472:Fluorouracil