Effect of prostaglandin A1 in porcine cells persistently infected with classical swine fever virus.
Cyclopentenone prostaglandins are potent inhibitors of a wide variety of RNA and DNA viruses. In this report we describe that prostaglandin A1 (PGA1) potently inhibited the replication of classical swine fever virus in cultures of PK-15 cells. The highest non-toxic dose (5 microg/ml) inhibited virus yield in 99% at the initial phase of infection and in 77% in persistent infected cells. However when PGA1 was removed from persistently infected cells, the inhibition of virus replication was partially reverted.
Freitas
Tânia Rosária Pereira
TR
Institute of Microbiology Professor Paulo de Góes, CCS, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, CEP: 21941-590, Brazil.
Caldas
Lúcio Ayres
LA
Rebello
Moacyr Alcoforado
MA
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002460:Cell Line; D006692:Classical Swine Fever Virus / Q000187:drug effects* / Q000254:growth & development; D011454:Prostaglandins A / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D011454:Prostaglandins A; C100573:prostaglandin A1