[Hematopoietic stem cell transplantation: is it an immunologic therapy?].
The graft-versus-tumor effect occurring after allogeneic (genetically different) haematopoietic cell transplantation for treating human malignancies, represents the clearest example of the power of the human immune system to eradicate cancer. Recent advances in our understanding of the immunobiology of stem-cell engraftment, tolerance and tumor eradication are allowing clinicians to better harness this powerful effect.
Olaya Vargas
Alberto
A
Programa de Progenitores Hematopoyéticos, Instituto Nacional de Pediatría, Av. Insurgentes Sur 3700-C, Col. Insurgentes Cuicuilco, CP 04530, México, DF.
Pérez Gonzáles
Oscar
O
D016026:Bone Marrow Transplantation; D006086:Graft vs Host Disease / Q000276:immunology; D020350:Graft vs Tumor Effect / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation; D006648:Histocompatibility; D006801:Humans; D007108:Immune Tolerance; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous / Q000276:immunology*