title: Imported human trichinellosis: sequential IgG4 antibody response to Trichinella spiralis.
abstract: Two out of five members of one household presented with clinical signs of trichinellosis after their return to the Netherlands. The family had consumed Trichinella-infected pork in Montenegro, formerly Yugoslavia. Serological tests were performed at 1, 2, 6, and 18 months after ingestion of the infected meat. Trichinella-specific IgM, IgG, and IgA antibodies measured in sera from symptomatic and asymptomatic patients remained positive up to 18 months after ingestion. The measured IgG4 antibody response directed to a 45 kDa Trichinella spiralis antigen also persisted 18 months after ingestion for three of the family members.
authors: Department of Parasitology and Mycology, National Institute of Public Health and the Environment (RIVM), PO Box 1, 3720 BA, Bilthoven, The Netherlands. elena.pinelli@rivm.nl
authors: E
authors: E
authors: Pinelli
authors: M
authors: M
authors: Mommers
authors: W
authors: W
authors: Homan
authors: T
authors: T
authors: van Maanen
authors: L M
authors: LM
authors: Kortbeek
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis*; D000917:Antibody Formation; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005190:Family; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008460:Meat; D018570:Risk Assessment; D012494:Sampling Studies; D012698:Serologic Tests; D014195:Travel; D017160:Trichinella spiralis / Q000302:isolation & purification*; D014235:Trichinellosis / Q000175:diagnosis* / Q000209:etiology
chemical_list: D000909:Antibodies, Helminth; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M