Synthesis and biological evaluation of substituted quinolines: potential treatment of protozoal and retroviral co-infections.
We report the synthesis of substituted quinolines and their in vitro biological evaluation against the causal agents of cutaneous leishmaniasis, visceral leishmaniasis, African trypanosomiasis and Chagas' disease. Furthermore, several quinolines have also been tested for their anti-retroviral activity in HIV-1 infected cells. The structure-activity relationships of these new synthetic compounds are discussed and emphasis was placed on the treatment of leishmania/HIV co-infections.
Fakhfakh
Mohammed A
MA
Laboratoire de Pharmacognosie (associé au CNRS-BioCIS), Faculté de Pharmacie, Université Paris-Sud, rue J.B. Clément, 92296, Châtenay-Malabry, France.
Fournet
Alain
A
Prina
Eric
E
Mouscadet
Jean-François
JF
Franck
Xavier
X
Hocquemiller
Reynald
R
Figadère
Bruno
B
D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007891:Leishmania / Q000145:classification / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D011528:Protozoan Infections / Q000150:complications / Q000188:drug therapy*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D014345:Trypanosoma / Q000145:classification / Q000187:drug effects
D011804:Quinolines