title: Gamma oscillations correlate with working memory load in humans.
abstract: Functional imaging of human cortex implicates a diverse network of brain regions supporting working memory - the capacity to hold and manipulate information for short periods of time. Although we are beginning to map out the brain networks supporting working memory, little is known about its physiological basis. We analyzed intracranial recordings from two epileptic patients as they performed a working memory task. Spectral analyses revealed that, in both patients, gamma (30-60 Hz) oscillations increased approximately linearly with memory load, tracking closely with memory load over the course of the trial. This constitutes the first evidence that gamma oscillations, widely implicated in perceptual processes, support the maintenance of multiple items in working memory.
authors: Department of Psychology, Syracuse University, Syracuse, NY 13244-2340, USA. mahoward@syr.edu
authors: Marc W
authors: MW
authors: Howard
authors: Daniel S
authors: DS
authors: Rizzuto
authors: Jeremy B
authors: JB
authors: Caplan
authors: Joseph R
authors: JR
authors: Madsen
authors: John
authors: J
authors: Lisman
authors: Richard
authors: R
authors: Aschenbrenner-Scheibe
authors: Andreas
authors: A
authors: Schulze-Bonhage
authors: Michael J
authors: MJ
authors: Kahana
mesh_terms: D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000503:physiopathology*; D002648:Child; D004827:Epilepsy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D009474:Neurons; D013223:Statistics as Topic