title: [Influence of the indometafen radioprotector on the immune reactivity].
abstract: In the experiments on dogs and mice it was shown that indometophene could modify the immune status of the body. Specific and non-specific resistance of mice to E. coli infection increased after indometophene administration. At the same time higher titers of normal anti-salmonella antibodies in mice serum and a higher phagocytic activity of neutrophils in the peripheral blood in dogs were found. The influence of the preparation on the content of the complement and normal antibodies-hemagglutinins was less pronounced. It was suggested that the indometophene ability to bustle immune reactivity of the body played a certain role in the mechanism of its radioprotective effect.
authors: State Research Center-Institute of Biophysics, Russian Ministry of Health, Moscow, 123182 Russia.
authors: P P
authors: PP
authors: Mikhaĭlov
authors: V N
authors: VN
authors: Mal'tsev
authors: T G
authors: TG
authors: Shliakova
authors: L I
authors: LI
authors: Khaustova
authors: S V
authors: SV
authors: Romanova
authors: V G
authors: VG
authors: Skachkova
authors: L G
authors: LG
authors: Arsent'eva
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis; D003692:Delayed-Action Preparations; D004285:Dogs; D004927:Escherichia coli Infections / Q000276:immunology / Q000517:prevention & control; D005260:Female; D006388:Hemagglutinins / Q000032:analysis; D007110:Immunity, Active / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011837:Radiation-Protective Agents / Q000494:pharmacology; D012475:Salmonella / Q000276:immunology; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D003692:Delayed-Action Preparations; D006388:Hemagglutinins; D011837:Radiation-Protective Agents; C091454:indometafen; D013629:Tamoxifen; D003165:Complement System Proteins