title: Thermomechanical analysis of soft-tissue thermotherapy.
abstract: Soft-tissue thermotherapy based on sub-ablative heating of collagenous tissues finds wide-spread application in medicine such as tissue welding, thermokeratoplasty, skin resurfacing, elimination of discogenic pain in the spine and treatment of joint instability. In this paper, heat-induced thermomechanical response characteristics of collagenous tissues are quantified by means of in vitro experimentation with a representative model tissue (New Zealand white rabbit patellar tendon). Three distinct heat-induced thermomechanical response regimes (defined by the rate of deformation and the variation of material properties) are identified. Arrhenius damage integral representation of collagenous tissue thermal history is shown to be adequate in establishing the master response curves for quantification of thermomechanical response for modeling purposes. The trade-off between the improved kinematical stability and compromised mechanical stability of the heated collagenous tissue is shown to be the major challenge hindering the success of subablative thermotherapies.
authors: Mechanical Engineering Department, Michigan State University, East Lansing, MI 48824, USA. aaksan@hms.harvard.edu
authors: Alptekin
authors: A
authors: Aksan
authors: John J
authors: JJ
authors: McGrath
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001696:Biomechanical Phenomena / Q000379:methods; D002056:Burns / Q000209:etiology / Q000517:prevention & control; D003198:Computer Simulation; D004548:Elasticity; D006358:Hot Temperature; D006979:Hyperthermia, Induced / Q000009:adverse effects / Q000379:methods*; D066298:In Vitro Techniques; D040542:Mechanotransduction, Cellular; D008954:Models, Biological; D017711:Nonlinear Dynamics; D017847:Patellar Ligament / Q000503:physiopathology* / Q000528:radiation effects*; D011817:Rabbits; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D013718:Tensile Strength; D016474:Weight-Bearing