title: New classes of antibacterial oxazolidinones with C-5, methylene O-linked heterocyclic side chains.
abstract: Exploration of the structure-activity relationships of the traditional C-5 acetamidomethyl side chain of the oxazolidonone antibacterials has yielded new, potent series of compounds of which the first examples, the O-linked iosoxazoles are described in detail, leading to the selection of the pre-clinical candidate AZD2563.
authors: AstraZeneca R&D Boston, Infection Discovery, 35 Gatehouse Park, Waltham, MA 02451, USA. gravestock@astrazeneca.com
authors: Michael B
authors: MB
authors: Gravestock
authors: David G
authors: DG
authors: Acton
authors: Michael J
authors: MJ
authors: Betts
authors: Michael
authors: M
authors: Dennis
authors: Glenn
authors: G
authors: Hatter
authors: Alexandra
authors: A
authors: McGregor
authors: Michael L
authors: ML
authors: Swain
authors: R Geoffrey
authors: RG
authors: Wilson
authors: Lisa
authors: L
authors: Woods
authors: Alan
authors: A
authors: Wookey
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006838:Hydrocarbons; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry*; D051379:Mice; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000472:pathogenicity; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D006571:Heterocyclic Compounds; D006838:Hydrocarbons; D023303:Oxazolidinones; C030011:carbene; C453362:posizolid; D008697:Methane