title: Secretory and vascular effects of adrenomedullin in gastric ulcer: role of CGRP- and adrenomedullin-receptors.
abstract: Adrenomedullin prevents damage of gastric mucosa in either reserpine-treated or pylorus-ligated rats. Pre-treatment with CGRP(8-37) resulted in a decrease of the gastro-protective effect of adrenomedullin in both models and reversed the inhibitory effect of adrenomedullin on gastric acid output in the pylorus-ligated rats. These adrenomedullin actions were less effectively modified by pre-treatment with adrenomedullin(22-52). These data suggest that the anti-ulcer effect of adrenomedullin is mainly related to its anti-secretory action, presumably mediated through CGRP-receptors.
authors: Dipartimento di Farmacologia Sperimentale e Clinica, Facoltà di Medicina e Chirurgia, Università di Catania, Viale A. Doria 6, Catania 95125, Italy.
authors: Salvatore
authors: S
authors: Salomone
authors: Antonina
authors: A
authors: Caruso
authors: Giuseppa
authors: G
authors: Martinez
authors: Vincenza Maria
authors: VM
authors: Cutuli
authors: Agata
authors: A
authors: Prato
authors: Alfredo
authors: A
authors: Bianchi
authors: Matilde
authors: M
authors: Amico-Roxas
authors: Giuseppe
authors: G
authors: Clementi
mesh_terms: D053607:Adrenomedullin; D000818:Animals; D006801:Humans; D008297:Male; D010455:Peptides / Q000378:metabolism*; D051381:Rats; D058265:Receptors, Adrenomedullin; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000378:metabolism*; D018000:Receptors, Peptide / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D013276:Stomach Ulcer / Q000378:metabolism*
chemical_list: D010455:Peptides; D058265:Receptors, Adrenomedullin; D018015:Receptors, Calcitonin Gene-Related Peptide; D018000:Receptors, Peptide; D053607:Adrenomedullin; D012701:Serotonin