FoxO3a eggs on fertility and aging.
The FoxO transcription factors (FoxO1a, 3a and 4) comprise a small subfamily of the Forkhead transcription factor family. An increasing number of studies has provided genetic evidence showing that Forkhead transcription factors control crucial steps in embryogenesis and are essential for the development of all germ layers and organs (for a recent review, see Ref. ). A recent study by Castrillon et al. has now added a function for FoxO3a in the control of follicular development.
Brenkman
Arjan B
AB
Laboratory of Physiological Chemistry, University Medical Center Utrecht, Stratenum, Universiteitsweg 100, 3584CG Utrecht, The Netherlands.
Burgering
Boudewijn M T
BM
D000375:Aging / Q000502:physiology*; D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology*; D005260:Female; D005298:Fertility / Q000502:physiology*; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; D006801:Humans; D006080:Ovarian Follicle / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*
D004268:DNA-Binding Proteins; C085126:FOXO1 protein, human; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; D014157:Transcription Factors