Titin--springing back to youth?
Mutations in the muscle protein titin have been linked to dilated cardiomyopathy, a condition in which the heart chambers are enlarged and blood is ineffectively pumped, in humans and in animal models. This protein, which is a component of sarcomeres, provides essential scaffolding for other muscle proteins and acts as a spring to confer passive elasticity on the cardiomyocyte. Several titin isoforms exist, and they display varying size and degrees of elasticity. We review two interesting reports that show how variations in titin isoforms might be implicated in cardiac failure.
Huq
Fawzia
F
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02129, USA.
Heist
E Kevin
EK
Hajjar
Roger J
RJ
D000375:Aging / Q000502:physiology; D000818:Animals; D009202:Cardiomyopathies / Q000378:metabolism*; D064211:Connectin; D006321:Heart / Q000502:physiology; D006801:Humans; D009124:Muscle Proteins / Q000096:biosynthesis / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism; D020033:Protein Isoforms; D011494:Protein Kinases / Q000096:biosynthesis / Q000502:physiology*; D012518:Sarcomeres / Q000378:metabolism / Q000502:physiology
D064211:Connectin; D009124:Muscle Proteins; D020033:Protein Isoforms; C577285:TTN protein, human; D011494:Protein Kinases