[Regularities of cytogenesis in the endocrine gastroenteropancreatic system in vertebrates].
This paper reviews the literature data and the results of authors' own investigations on cytogenesis of endocrine cells of gastro-entero-pancreatic (GEP-) system in vertebrate animals and man. In pancreas two groups of sources of endocrine cell development were distinguished including both intra- and extrainsular. In cytogenesis of mucosal endocrine cells in gastrointestinal tract (GIT) the major role belongs to the stem cells which differentiate through the stage of committed precursors ("agranular cells"). Pancreas and GIT epithelium are characterized by the formation of endocrine cells from exocrine ones. The data presented provide the indication of the endodermal origin of endocrine cells of GEP-system.
Puzyrev
A A
AA
Department of Medico-Biological Research, Central Scientific Research Laboratory, I.I. Mechnikov State Medical Academy, St. Petersburg.
Ivanova
V F
VF
Kostiukevich
S V
SV
D000818:Animals; D015550:Cell Degranulation / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D004064:Digestive System / Q000166:cytology*; D019858:Enteroendocrine Cells / Q000166:cytology*; D041981:Gastrointestinal Tract / Q000166:cytology; D006801:Humans; D010179:Pancreas / Q000166:cytology; D014714:Vertebrates / Q000502:physiology