title: Multicenter case-control study of risk factors associated with development of vaccine-associated sarcomas in cats.
abstract: OBJECTIVE
  To determine whether particular vaccine brands, other injectable medications, customary vaccination practices, or various host factors were associated with the formation of vaccine-associated sarcomas in cats.
  
  
  METHODS
  Prospective multicenter case-control study.
  
  
  METHODS
  Cats in the United States and Canada with soft tissue sarcomas or basal cell tumors.
  
  
  METHODS
  Veterinarians submitting biopsy specimens from cats with a confirmed diagnosis of soft tissue sarcoma or basal cell tumor were contacted for patient medical history. Time window statistical analyses were used in conjunction with various assumptions about case definitions.
  
  
  RESULTS
  No single vaccine brand or manufacturer within antigen class was found to be associated with sarcoma formation. Factors related to vaccine administration were also not associated with sarcoma development, with the possible exception of vaccine temperature prior to injection. Two injectable medications (long-acting penicillin and methyl prednisolone acetate) were administered to case cats more frequently than to control cats.
  
  
  CONCLUSIONS
  Findings do not support the hypotheses that specific brands or types of vaccine within antigen class, vaccine practices such as reuse of syringes, concomitant viral infection, history of trauma, or residence either increase or decrease the risk of vaccine-associated sarcoma formation in cats. There was evidence to suggest that certain long-acting injectable medications may also be associated with sarcoma formation.
authors: Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
authors: Philip H
authors: PH
authors: Kass
authors: William L
authors: WL
authors: Spangler
authors: Mattie J
authors: MJ
authors: Hendrick
authors: Lawrence D
authors: LD
authors: McGill
authors: D Glen
authors: DG
authors: Esplin
authors: Sally
authors: S
authors: Lester
authors: Margaret
authors: M
authors: Slater
authors: E Kathryn
authors: EK
authors: Meyer
authors: Faith
authors: F
authors: Boucher
authors: Erika M
authors: EM
authors: Peters
authors: Glenna G
authors: GG
authors: Gobar
authors: Thurein
authors: T
authors: Htoo
authors: Kendra
authors: K
authors: Decile
mesh_terms: D000818:Animals; D002170:Canada / Q000453:epidemiology; D016022:Case-Control Studies; D002371:Cat Diseases / Q000453:epidemiology / Q000209:etiology*; D002415:Cats; D005260:Female; D015994:Incidence; D008297:Male; D018295:Neoplasms, Basal Cell / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D011446:Prospective Studies; D012307:Risk Factors; D012509:Sarcoma / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D012983:Soft Tissue Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000662:veterinary*; D014481:United States / Q000453:epidemiology; D014611:Vaccination / Q000009:adverse effects / Q000379:methods / Q000662:veterinary*