The crystal structure of a novel copper(II) complex with asymmetric ligand derived from l-histidine.
The crystal structure of a novel copper(II) complex with a potentially hexadentate Schiff base ligand derived from l-histidine has been solved by a single-crystal X-ray diffraction method at pH 7.4. The copper(II) ion is coordinated asymmetrically by a tetradentate ligand with the amino and imidazole imido nitrogen atoms on one side versus imino nitrogen and carboxylate oxygen atoms on the other side in a distorted square-planar geometry. The formation of an infinite chain through carboxylate coordination is observed. The novel ligand is obtained by the reaction between the l-histidine molecules coordinated to copper(II) and 4-hydroxy-4-methylpentan-2-one formed by aldol condensation of acetone. This complex provides insights into a possible structural arrangement between copper(II) and l-histidine which is physiologically important and abundantly present in biological systems.
Deschamps
Patrick
P
Department of Structural Biology and Biochemistry, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada.
Kulkarni
Prasad P
PP
Sarkar
Bibudhendra
B
D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006639:Histidine / Q000031:analogs & derivatives*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry
D008024:Ligands; D009942:Organometallic Compounds; D012545:Schiff Bases; D006639:Histidine; D003300:Copper