title: Unique pattern of fibrosing cholestatic hepatitis after liver transplantation.
abstract: OBJECTIVE
  To explore the pathological features and the differential diagnosis of recurrent HBV after liver transplantation.
  
  
  METHODS
  One case of liver transplantation for HBV cirrhosis was subjected to liver biopsies on time postoperatively.
  
  
  RESULTS
  25 days after liver transplantation, serologic HBsAg, HBeAg and HBV-DNA of the patient became negative, but HBsAg was positive again on day 58 after liver transplantation. Histopathological examination showed balloon-like changes of hepatocytes with fragmental necrosis, fibrosis in the portal areas and around the portal veins, cholestasis in some hepatocytes and canaliculi, and positive HBsAg and HBcAg with immunohistochemical staining. clinically hepatic enzyme levels progressively increased, maintained for some time, and decreased rapidly at last. Stubborn hypoproteinemia was associated with the aggregation of general condition of the patient.
  
  
  CONCLUSIONS
  Fibrosing cholestatic hepatitis (FCH) is a special type in recurrent infection of HBV after liver transplantation. It has a serious clinical process and specific pathological changes different from those of the usual HBV.
authors: Departments of Pathology and Surgery, First Affiliated Hospital, Harbin Medical University, Harbin 150001, China.
authors: Jia-Wei
authors: JW
authors: Chen
authors: Da-Zhi
authors: DZ
authors: Chen
authors: Zhao-Min
authors: ZM
authors: Chen
mesh_terms: D001706:Biopsy; D002779:Cholestasis / Q000473:pathology*; D019694:Hepatitis B, Chronic / Q000473:pathology* / Q000601:surgery*; D022781:Hepatocytes / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000473:pathology