Synthesis of novel antitumor agent 1-methoxy-5,10- dioxo-5,10-dihydro-1H-benzo[g]isochromene carboxylic acid (3-dimethylylaminopropyl)amide with a dual role Pd(II) catalyst.
A convenient and simple method for the synthesis of 1-methoxy-5,10-dioxo-5,10-dihydro-1H-benzo[g]isochromene-3-carboxylic acid (3-(dimethylamino)propyl)amide 4c was developed. The key step involves the easy formation of 1,3-disubstituted cyclic alkenyl ether, an important framework of isochromene natural products, with a dual role Pd(II) catalyst.
Mondal
Somnath
S
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
Nogami
Tsutomu
T
Asao
Naoki
N
Yamamoto
Yoshinori
Y
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D008956:Models, Chemical; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
C482826:1-methoxy-5,10- dioxo-5,10-dihydro-1H-benzo(g)isochromene carboxylic acid (3-dimethylylaminopropyl)amide; D000970:Antineoplastic Agents; D001578:Benzopyrans; D010165:Palladium