title: The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice.
abstract: To extend our earlier data on synergistic action of tetrahydroisoquinolines and morphine, we have investigated the analgesic effects of 1,2,3,4-tetrahydroisoquinoline (TIQ) and its 1-methyl-(1-MeTIQ) and N-methyl (N-MeTIQ) analogs on analgesia induced by morphine and oxotremorine. 1-MeTIQ and N-MeTIQ induced a moderate, delayed and prolonged analgesic action measured in the tail-flick test in CD-1 mice; 1-MeTIQ and TIQ prolonged the opiate (morphine, 2.5 mg/kg i.p.) analgesia while TIQ and N-TIQ potentiated cholinergic (oxotremorine, 0.02 mg/kg i.p.) analgesia. The involvement of the opioid and noradrenergic systems in this effect is discussed.
authors: Department of Biochemistry, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland. nfvetula@cyf-kr.edu.pl
authors: J
authors: J
authors: Vetulani
authors: F
authors: F
authors: Pavone
authors: B
authors: B
authors: Przewłocka
authors: V
authors: V
authors: Borghi
authors: I
authors: I
authors: Nalepa
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D004357:Drug Synergism; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism; D018847:Opioid Peptides / Q000378:metabolism; D010095:Oxotremorine / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D010147:Pain Measurement / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects / Q000378:metabolism; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism; D044005:Tetrahydroisoquinolines / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D018847:Opioid Peptides; D018341:Receptors, Adrenergic, alpha-2; D011957:Receptors, Opioid; D044005:Tetrahydroisoquinolines; C050386:1-methyl-1,2,3,4-tetrahydroisoquinoline; C014843:1,2,3,4-tetrahydroisoquinoline; D010095:Oxotremorine; D009020:Morphine; D000109:Acetylcholine; D009638:Norepinephrine