title: Revision of linezolid disk diffusion quality control guidelines for testing Staphylococcus aureus ATCC 25923: an independent seven-laboratory trial.
abstract: The accuracy of the published disk diffusion quality control (QC) range for linezolid for Staphylococcus aureus ATCC 25923 has been reported to be problematic, prompting a multicenter study to determine if revision was necessary. Five out of seven laboratories reported values outside the current QC range. Three participants had significant (13.3-60.0%) 'unacceptable' results with zones smaller than the established range. Overall, a range of 21-32 mm was shown (82.4% within the NCCLS published range). A revision (25-31 mm; 95.7% of results) of the QC range is necessary when testing S. aureus ATCC 25923 against linezolid.
authors: The JONES Group/JMI Laboratories, North Liberty, Iowa 52317, USA. douglas-biedenbach@jmilabs.com
authors: D J
authors: DJ
authors: Biedenbach
authors: R N
authors: RN
authors: Jones
mesh_terms: D000081:Acetamides / Q000494:pharmacology* / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D005779:Immunodiffusion / Q000379:methods / Q000592:standards*; D000069349:Linezolid; D023303:Oxazolidinones / Q000494:pharmacology* / Q000627:therapeutic use; D011786:Quality Control; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000254:growth & development*
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid