Facile and racemization-free conversion of chiral nitriles into pyridine derivatives.
The results described herein demonstrate how the very mild reaction conditions of the Co(I)-catalyzed photochemical [2 + 2 + 2] cyclocotrimerization are suited to prepare chiral compounds containing unsubstituted and polysubstituted 2-pyridyl moieties starting from chiral nitriles without any detectable loss of enantiomerical purity. This further increases the already very broad synthetic scope of this particular reaction.
Heller
Barbara
B
Leibniz-Institut für Organische Katalyse an der Universität Rostock e.V., Buchbinderstr. 5-6, 18055 Rostock, Germany. barbara.heller@ifok.uni-rostock.de
Sundermann
Bernd
B
Fischer
Christine
C
You
Jingsong
J
Chen
Waiqiang
W
Drexler
Hans-Joachim
HJ
Knochel
Paul
P
Bonrath
Werner
W
Gutnov
Andrey
A