title: Diagnostic and neural analysis of skin cancer (DANAOS). A multicentre study for collection and computer-aided analysis of data from pigmented skin lesions using digital dermoscopy.
abstract: BACKGROUND
  Early detection of melanomas by means of diverse screening campaigns is an important step towards a reduction in mortality. Computer-aided analysis of digital images obtained by dermoscopy has been reported to be an accurate, practical and time-saving tool for the evaluation of pigmented skin lesions (PSLs). A prototype for the computer-aided diagnosis of PSLs using artificial neural networks (NNs) has recently been developed: diagnostic and neural analysis of skin cancer (DANAOS).
  
  
  OBJECTIVE
  To demonstrate the accuracy of PSL diagnosis by the DANAOS expert system, a multicentre study on a diverse multinational population was conducted.
  
  
  METHODS
  A calibrated camera system was developed and used to collect images of PSLs in a multicentre study in 13 dermatology centres in nine European countries. The dataset was used to train an NN expert system for the computer-aided diagnosis of melanoma. We analysed different aspects of the data collection and its influence on the performance of the expert system. The NN expert system was trained with a dataset of 2218 dermoscopic images of PSLs.
  
  
  RESULTS
  The resulting expert system showed a performance similar to that of dermatologists as published in the literature. The performance depended on the size and quality of the database and its selection.
  
  
  CONCLUSIONS
  The need for a large database, the usefulness of multicentre data collection, as well as the benefit of a representative collection of cases from clinical practice, were demonstrated in this trial. Images that were difficult to classify using the NN expert system were not identical to those found difficult to classify by clinicians. We suggest therefore that the combination of clinician and computer may potentially increase the accuracy of PSL diagnosis. This may result in improved detection of melanoma and a reduction in unnecessary excisions.
authors: Department of Dermatology, Ruhr-University Bochum, Gudrunstrasse 56, D-44791 Bochum, Germany. k.hoffmann@derma.de
authors: K
authors: K
authors: Hoffmann
authors: T
authors: T
authors: Gambichler
authors: A
authors: A
authors: Rick
authors: M
authors: M
authors: Kreutz
authors: M
authors: M
authors: Anschuetz
authors: T
authors: T
authors: Grünendick
authors: A
authors: A
authors: Orlikov
authors: S
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authors: Gehlen
authors: R
authors: R
authors: Perotti
authors: L
authors: L
authors: Andreassi
authors: J
authors: J
authors: Newton Bishop
authors: J-P
authors: JP
authors: Césarini
authors: T
authors: T
authors: Fischer
authors: P J
authors: PJ
authors: Frosch
authors: R
authors: R
authors: Lindskov
authors: R
authors: R
authors: Mackie
authors: D
authors: D
authors: Nashan
authors: A
authors: A
authors: Sommer
authors: M
authors: M
authors: Neumann
authors: J P
authors: JP
authors: Ortonne
authors: P
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authors: Bahadoran
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authors: PF
authors: Penas
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authors: Zoras
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authors: Altmeyer
mesh_terms: D000328:Adult; D019992:Databases as Topic; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008545:Melanoma / Q000175:diagnosis*; D018715:Microscopy, Video; D008875:Middle Aged; D016571:Neural Networks, Computer; D009508:Nevus, Pigmented / Q000175:diagnosis; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000175:diagnosis*