title: Hypersensitivity to progesterone-in-oil after in vitro fertilization and embryo transfer.
abstract: OBJECTIVE
  To report the occurrence and management of pulmonary compromise, marked leukocytosis, and eosinophilia in a patient receiving P-in-oil after IVF and embryo transfer.
  
  
  METHODS
  Case report.A tertiary referral reproductive medicine unit.
  
  
  METHODS
  A 29-year-old patient receiving P-in-oil supplementation after IVF embryo transfer.
  
  
  METHODS
  Extensive diagnostic testing and surveillance for hypersensitivity to P in sesame oil; development of an alternative oil-based P-in-oil suspension.
  
  
  METHODS
  Tolerance of alternative P vehicle; clinical pregnancy.
  
  
  RESULTS
  The patient tolerated an alternative P oil vehicle and successfully achieved a clinical pregnancy after frozen embryo transfer.
  
  
  CONCLUSIONS
  Although rare, hypersensitivity reactions may occur in patients receiving P-in-oil supplementation after IVF embryo transfer. Testing for tolerance and subsequent use of alternative P vehicles may be an effective strategy in managing patients with sensitivity to P-in-oil.
authors: Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA. phy.jenniferlynn@mayo.edu
authors: Jennifer L
authors: JL
authors: Phy
authors: William T
authors: WT
authors: Weiss
authors: Catherine R
authors: CR
authors: Weiler
authors: Mark A
authors: MA
authors: Damario
mesh_terms: D000328:Adult; D004342:Drug Hypersensitivity / Q000150:complications / Q000209:etiology*; D004624:Embryo Transfer; D004802:Eosinophilia / Q000209:etiology; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007964:Leukocytosis / Q000209:etiology; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology; D014677:Pharmaceutical Vehicles / Q000009:adverse effects*; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage*; D013902:Radiography, Thoracic; D012715:Sesame Oil / Q000009:adverse effects*
chemical_list: D014677:Pharmaceutical Vehicles; D011374:Progesterone; D012715:Sesame Oil