Cancer and aging: yin, yang, and p53.
The author discusses a recent paper published in Nature that shows that a hyperactive allele of the tumor suppressor p53 leads to the development of some premature aging phenotypes in mice. This new discovery is discussed in light of previous findings related to mechanisms of aging.
Campisi
Judith
J
Lawrence Berkeley National Laboratory, MS 84-171, 1 Cyclotron Road, Berkeley, CA 94720, USA. jcampisi@lbl.gov
D000375:Aging / Q000235:genetics / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D051379:Mice; D009374:Neoplasms, Experimental / Q000235:genetics / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000502:physiology*
D016159:Tumor Suppressor Protein p53