Administration of tacrolimus in 50 liver transplantation patients.
OBJECTIVE
To present a good tacrolimus (FK506) administration protocol in liver transplantation.


METHODS
Fifty liver transplantation patients were classified into FK506 high-concentration (20 patients), FK506 mid-concentration (20), CsA-FK506 (5) and FK506-CsA (5) groups. Clinical manifestations, FK506 side-effects and pathological changes were observed.


RESULTS
The FK506 high-concentration group showed complications such as infection and liver function damage. The FK506 mid-concentration group showed excellent therapeutic results and some complications easy to deal with.


CONCLUSIONS
FK506 is a highly effective immunosuppressive agent and the mid-concentration protocol is a better one.
Ye
Qi-Fa
QF
Institute of Organ Transplantation and Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. yqf_china@sina.com
Ruzig
Manal Abdel
MA
Gong
Nian-Qiao
NQ
D000293:Adolescent; D000328:Adult; D002648:Child; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D011182:Postoperative Care; D019233:Retreatment; D016559:Tacrolimus / Q000008:administration & dosage* / Q000009:adverse effects
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus