title: Can mosquitoes be bitten? A new hope for anti-malarial drug design.
abstract: The crystal structure of PfPK5, a cyclin-dependent kinase from Plasmodium falciparum, is the first CDK structure determined from a nonhuman source and represents a potential new target for anti-malarial drug development.
authors: Sandler Center for Basic Parasitic Disease Research, Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94143, USA.
authors: Linda S
authors: LS
authors: Brinen
authors: Thomas J
authors: TJ
authors: Stout
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D009033:Culicidae; D016213:Cyclins / Q000737:chemistry*; D015195:Drug Design; D004351:Drug Resistance; D006801:Humans; D010963:Plasmodium falciparum / Q000201:enzymology*; D011487:Protein Conformation; D015800:Protozoan Proteins / Q000737:chemistry*
chemical_list: D000962:Antimalarials; D016213:Cyclins; C406811:PfPK5 protein, Plasmodium falciparum; D015800:Protozoan Proteins