Bioevaluation of radioactive bandages in a murine model of melanoma.
OBJECTIVE
To study the effectiveness of a radioactive bandage incorporating a beta(-) emitter for the treatment of superficial tumours like melanoma.


METHODS
(188)Re tin particles were immobilized on a bandage patch ((188)Re bandage). The effectiveness of the (188)Re bandage for controlling tumour growth was tested in C57BL/6 mice bearing BL6/FIO melanoma. The effect of the single dose delivered, two-dose treatment and time of contact of bandages on the skin was studied by following tumour size.


RESULTS
Tumour growth was delayed significantly in treated animals compared with controls. Complete tumour regression was observed with some doses of radiation. Histology studies and dose-rate calculations were also carried out to evaluate the effectiveness of (188)Re bandages.


CONCLUSIONS
Radioactive bandages could be a promising modality for the treatment of skin cancers.
Mukherjee
A
A
Radiopharmaceuticals Division, Animal Sciences, Cancer Research Institute, Mumbai, India.
Pandey
U
U
Sarma
H D
HD
Gupta
S K
SK
Ingle
A D
AD
Pillai
M R A
MR
Venkatesh
M
M
D000818:Animals; D001458:Bandages; D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods*; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008297:Male; D008545:Melanoma / Q000473:pathology* / Q000532:radiotherapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D011868:Radioisotopes / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D012211:Rhenium / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000473:pathology* / Q000532:radiotherapy*; D016896:Treatment Outcome
D011868:Radioisotopes; D012211:Rhenium