[Sphingolipid and apoptosis].
Over the last decade, considerable progress has been made in the study of sphingolipids with the development of biological techniques. Sphingolipids play important roles in diverse physiological process, including cytoskeleton migration, angiogenesis, embryonic development and signal transduction. Except for this, the lastest evidence has suggested that sphingolipids and their metabolite (ceramide, sphingosine, sphingosine 1-phosphate) can induce apoptosis in a wide variety of tumor cell lines such as LoVo HT29, Bel7402, A549, CNE2 cells. This paper is attempted to review the recent advances of investigation into the relationship between sphingolipids and apoptosis.
Wang
Jing
J
College of Food Science, China Agricultural University, Beijing 100094.
Hu
Xiao-Song
XS
Shi
Jie-Ping
JP
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002465:Cell Movement; D002518:Ceramides / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D006801:Humans; D008246:Lysophospholipids / Q000502:physiology; D018919:Neovascularization, Physiologic; D013107:Sphingolipids / Q000378:metabolism / Q000502:physiology*; D013110:Sphingosine / Q000031:analogs & derivatives / Q000502:physiology
D002518:Ceramides; D008246:Lysophospholipids; D013107:Sphingolipids; C060506:sphingosine 1-phosphate; D013110:Sphingosine