5'-Amino-5'-deoxyaristeromycin and its antiviral properties.
An efficient, three-step synthesis of 5'-amino-5'-deoxyaristeromycin (5), from a protected form of aristeromycin (6), is described. Compound 5 was evaluated against a large number of viruses. It showed weak activity towards vaccinia, herpes simplex virus 2, and cytomegalovirus. No other activity was observed. Compound 5 displayed some cytotoxicity towards the host cell lines human foreskin fibroblast, Daudi, and human T-lymphocyte (CEM).
Rajappan
Vasanthakumar P
VP
Department of Chemistry, Auburn University, Auburn, AL 36849, USA.
Schneller
Stewart W
SW
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects; D003839:Deoxyadenosines / Q000737:chemistry / Q000494:pharmacology*; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D014616:Vaccinia virus / Q000187:drug effects
C488096:5'-amino-5'-deoxyaristeromycin; D000998:Antiviral Agents; D003839:Deoxyadenosines