Negative selection and autoimmunity.
The impaired elimination of self-reactive T cells is one factor that contributes to autoimmunity. Although the mechanism of thymic negative selection has been studied for decades, recent data demonstrate that the mechanisms underlying this fundamental process remain extremely controversial. Nonetheless, new models such as the Aire-deficient mice have demonstrated the importance of thymic negative selection in autoimmune disease progression in mice and humans.
Ohashi
Pamela S
PS
Ontario Cancer Institute, University Health Network, 610 University Avenue, Toronto ON M5G 2M9 Canada.
D000818:Animals; D017209:Apoptosis / Q000276:immunology / Q000502:physiology; D015551:Autoimmunity / Q000276:immunology* / Q000502:physiology; D017637:Clonal Deletion / Q000276:immunology* / Q000502:physiology; D006801:Humans; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology; D014157:Transcription Factors / Q000276:immunology / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology; D000096927:AIRE Protein
D018124:Receptors, Tumor Necrosis Factor; D014157:Transcription Factors; D014409:Tumor Necrosis Factor-alpha; D000096927:AIRE Protein