Differential involvement of spinal protein kinase C and protein kinase A in neuropathic and inflammatory pain in mice.
In the present study, we demonstrated the differential role of spinal protein kinases in neuropathic and inflammatory pain. Mice with sciatic nerve ligation exhibited a spinal protein kinase C (PKC)-dependent neuropathic pain-like state. In contrast, an intraplanter injection of inflammatory agent caused a protein kinase A (PKA)-related thermal hyperalgesia. These findings suggest that the substantial activation of spinal PKC and PKA may differentially contribute to the development of respective chronic pain-like state in mice.
Yajima
Yoshinori
Y
Department of Toxicology, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Narita
Minoru
M
Shimamura
Masahiro
M
Narita
Michiko
M
Kubota
Chiharu
C
Suzuki
Tsutomu
T
D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006930:Hyperalgesia / Q000139:chemically induced / Q000201:enzymology / Q000503:physiopathology; D007150:Immunohistochemistry; D007249:Inflammation / Q000201:enzymology* / Q000503:physiopathology; D018836:Inflammation Mediators / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009437:Neuralgia / Q000201:enzymology* / Q000503:physiopathology; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology; D010523:Peripheral Nervous System Diseases / Q000201:enzymology* / Q000503:physiopathology; D020671:Posterior Horn Cells / Q000166:cytology / Q000201:enzymology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D020426:Sciatic Neuropathy / Q000201:enzymology / Q000503:physiopathology; D013116:Spinal Cord / Q000166:cytology / Q000201:enzymology*; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology
D004791:Enzyme Inhibitors; D018836:Inflammation Mediators; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C