title: Measurement of skeletal muscle mass in Duchenne muscular dystrophy: use of 24-h creatinine excretion.
abstract: Creatinine concentration in 24-h urine has been proposed as an indirect measure of body skeletal muscle mass (SMM). We attempted to correlate urinary creatinine levels with SMM in eight patients with Duchenne muscular dystrophy, a progressive disease in which the degree of muscle wasting parallels the rate of progression. Magnetic resonance imaging and a newly developed protocol for image analysis were used for the measurement of SMM. The patients ate a creatine-free diet for the week before urine collection. Creatinine was measured with an enzymatic-colorimetric method. Mean (+/-SD) SMM value was 5.4+/-2.5 kg and urine creatinine levels 205.8+/-96.4 mg/day. Daily urinary creatinine excretion did not correlate with SMM. The simple creatinine determination in urine cannot predict SMM in Duchenne muscular dystrophy.
authors: IRCCS Foundation, Neurological Institute C Mondino, Pavia, Italy.
authors: D
authors: D
authors: Franciotta
authors: M C
authors: MC
authors: Zanardi
authors: L
authors: L
authors: Albertotti
authors: S
authors: S
authors: Orcesi
authors: A
authors: A
authors: Berardinelli
authors: A
authors: A
authors: Pichiecchio
authors: C
authors: C
authors: Uggetti
authors: A
authors: A
authors: Tagliabue
mesh_terms: D015415:Biomarkers / Q000652:urine; D001827:Body Height; D001835:Body Weight; D002648:Child; D003404:Creatinine / Q000652:urine*; D006801:Humans; D018482:Muscle, Skeletal / Q000033:anatomy & histology*; D020388:Muscular Dystrophy, Duchenne / Q000503:physiopathology*; D012044:Regression Analysis; D015203:Reproducibility of Results
chemical_list: D015415:Biomarkers; D003404:Creatinine