Solid phase synthesis of 2-aminoquinazoline-based compounds.
A versatile method for the solid-phase synthesis of 2-aminoquinazoline-based derivatives, 3-substituted-3,4-dihydroquinazolin-2-amines and imidazoquinazolines, has been developed. They were obtained by treating the amino group of polymer-linked amino acids with 2-nitrobenzaldehyde followed by reduction of the nitro group to an amine. Cyclization of the resulting immobilized intermediates with cyanogen bromide followed by acidic/basic cleavage yielded the desired quinazoline-based compounds in high yields and purities.
Srivastava
Gaurav K
GK
Medicinal Chemistry Division and NMR Lab, Sophisticated Analytical Instrumentation Facility, Central Drug Research Institute, Lucknow 226001, India.
Kesarwani
Amit P
AP
Grover
Rajesh K
RK
Roy
Raja
R
Srinivasan
T
T
Kundu
Bijoy
B
D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*
D000634:Aminoquinolines