Regulation of the neutrophil-mediated inflammatory response to infection.
Human polymorphonuclear leukocytes (PMNs) are the first line of defense against invading microorganisms and contribute significantly to inflammation. Recent evidence suggests that resolution of neutrophil-mediated inflammation is facilitated by an apoptosis differentiation program, a final stage of transcriptionally regulated PMN maturation that is accelerated significantly by phagocytosis.
Kobayashi
Scott D
SD
Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA.
Voyich
Jovanka M
JM
DeLeo
Frank R
FR
D017209:Apoptosis; D001424:Bacterial Infections / Q000276:immunology*; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis