The neuroexcitatory morphine metabolite, morphine-3-glucuronide (M3G), is not neurotoxic in primary cultures of either hippocampal or cerebellar granule neurones.
Hemstapat
Kamondanai
K
School of Pharmacy, The University of Queensland, St. Lucia Campus, Brisbane, Queensland, 4072, Australia.
Smith
Steven A
SA
Monteith
Gregory R
GR
Smith
Maree T
MT
D000818:Animals; D002478:Cells, Cultured; D000697:Central Nervous System Stimulants / Q000633:toxicity*; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects*; D004622:Embryo, Mammalian / Q000166:cytology; D005260:Female; D018698:Glutamic Acid / Q000494:pharmacology; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D009020:Morphine / Q000378:metabolism / Q000494:pharmacology; D009022:Morphine Derivatives / Q000633:toxicity*; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D000697:Central Nervous System Stimulants; D009022:Morphine Derivatives; D018698:Glutamic Acid; D009020:Morphine; C018108:morphine-3-glucuronide