title: Effect of prostaglandin A1 in porcine cells persistently infected with classical swine fever virus.
abstract: Cyclopentenone prostaglandins are potent inhibitors of a wide variety of RNA and DNA viruses. In this report we describe that prostaglandin A1 (PGA1) potently inhibited the replication of classical swine fever virus in cultures of PK-15 cells. The highest non-toxic dose (5 microg/ml) inhibited virus yield in 99% at the initial phase of infection and in 77% in persistent infected cells. However when PGA1 was removed from persistently infected cells, the inhibition of virus replication was partially reverted.
authors: Institute of Microbiology Professor Paulo de Góes, CCS, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, CEP: 21941-590, Brazil.
authors: Tânia Rosária Pereira
authors: TR
authors: Freitas
authors: Lúcio Ayres
authors: LA
authors: Caldas
authors: Moacyr Alcoforado
authors: MA
authors: Rebello
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D002460:Cell Line; D006692:Classical Swine Fever Virus / Q000187:drug effects* / Q000254:growth & development; D011454:Prostaglandins A / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D011454:Prostaglandins A; C100573:prostaglandin A1