Development of silicone rubber hollow fiber membrane oxygenator for ECMO.
Silicone rubber hollow fiber membrane produces an ideal gas exchange for long-term ECMO due to nonporous characteristics. The extracapillary type silicone rubber ECMO oxygenator having an ultrathin hollow fiber membrane was developed for pediatric application. The test modules were compared to conventional silicone coil-type ECMO modules. In vitro experiments demonstrated a higher O2 and CO2 transfer rate, lower blood flow resistance, and less hemolysis than the conventional silicone coil-type modules. This oxygenator was combined with the Gyro C1E3 centrifugal pump, and three ex vivo experiments were conducted to simulate pediatric V-A ECMO condition. Four day and 6 day experiments were conducted in cases 1 and 2, respectively. Case 3 was a long-term experiment up to 2 weeks. No plasma leakage and stable gas performances were achieved. The plasma free hemoglobin was maintained within a normal range. This compact pump-oxygenator system in conjunction with the Gyro C1E3 centrifugal pump has potential for a hybrid total ECMO system.
Motomura
Tadashi
T
Baylor College of Medicine, Michael E. DeBakey Department of Surgery, Houston, TX 77054, USA. Motomura@bcm.tmc.edu
Maeda
Tomohiro
T
Kawahito
Shiniji
S
Matsui
Takahiro
T
Ichikawa
Seiji
S
Ishitoya
Hiroshi
H
Kawamura
Masaki
M
Shinohara
Toshiyuki
T
Sato
Koshiro
K
Kawaguchi
Yoichiro
Y
Taylor
Deborah
D
Oestmann
Daniel
D
Glueck
Julie
J
Nosé
Yukihiko
Y
D000818:Animals; D002417:Cattle; D015199:Extracorporeal Membrane Oxygenation; D006454:Hemoglobins / Q000032:analysis; D008422:Materials Testing; D010107:Oxygenators, Membrane; D012826:Silicone Elastomers
D006454:Hemoglobins; D012826:Silicone Elastomers