title: [Altered of zinc finger proteins expression in FL cells following benzo [a] pyrene treatment].
abstract: To understand benzo[a]pyrene (B[a]P) mediated cellular responses, and to provide clues to explore molecular mechanism of mutagenesis and carcinogenesis induced by B[a]P.
  
  
  
  Two-dimensional electrophoresis (2-DE) was used to investigate the protein expression levels of FL cells after B[a]P exposure, matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF-MS) combined with database search was applied to identify the differentially expressed proteins.
  
  
  
  Statistical analysis showed that the volumes of 47 protein spots were altered after B[a]P treatment (P<0.05) and 23 proteins were successfully identified, including zinc finger proteins, SWI/SNF related protein, Bromo domain containing domain and other proteins.
  
  
  
  These affected proteins may be involved in the cellular responses to B[a]P exposure, and may mediate the B[a]P induced mutagenesis and carcinogenesis.
authors: Department of Pathophysiology, College of Medicine, Zhejiang University, Hangzhou 310031, China.
authors: Zhi-hua
authors: ZH
authors: Gao
authors: Jing-hua
authors: JH
authors: Yang
authors: Jun
authors: J
authors: Yang
authors: Ying-nian
authors: YN
authors: Yu
mesh_terms: D000650:Amnion / Q000737:chemistry / Q000166:cytology / Q000187:drug effects*; D001564:Benzo(a)pyrene / Q000633:toxicity*; D002478:Cells, Cultured; D004260:DNA Repair; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D040901:Proteomics; D016335:Zinc Fingers
chemical_list: D001564:Benzo(a)pyrene