Moderate exercise and fibrinolytic potential in obese sedentary men with metabolic syndrome.
OBJECTIVE
To investigate the impact of 30-minute walking exercise at 70% VO2max on tissue plasminogen activator (t-PA) Ag and plasminogen activator inhibitor type 1 (PAI-1) Ag in obese sedentary males.


METHODS
A controlled observational study of the effect of a 30-minute acute exercise bout at 70% VO2max on plasma t-PA antigen and PAI-1 antigen in 10 obese sedentary males matched for age, ethnic origin, and smoking status with 10 nonobese sedentary male controls.


RESULTS
The obese group remained hypofibrinolytic compared with the nonobese group at all time-points before, during, and after exercise. t-PA increased in both groups with exercise before returning to baseline values 30 minutes after exercise. PAI-1 did not significantly change in either group with exercise but rose significantly 30 minutes after exercise in the obese group.


CONCLUSIONS
The reduction in fibrinolytic potential in the obese group represents an increase in acute thrombotic risk and could account for the increased incidence of exercise-associated myocardial infarction observed in sedentary obese groups.
Morris
Penelope J
PJ
Centre for Obesity Research, Luton & Dunstable Hospital NHS Trust, Lewsey Road, Luton, Beds LU4 0DZ, United Kingdom. penny.morris@ldh-tr.anglox.nhs.uk
Packianathan
C Ira
CI
Van Blerk
Catherine J
CJ
Finer
Nicholas
N
D000328:Adult; D005006:Ethnicity; D015444:Exercise / Q000502:physiology*; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000503:physiopathology*; D009203:Myocardial Infarction / Q000209:etiology; D009765:Obesity / Q000503:physiopathology*; D010101:Oxygen Consumption; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D012307:Risk Factors; D012907:Smoking; D013927:Thrombosis / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000097:blood
D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator