Anticholinesterase mechanism as a factor of immunotoxicity of various chemical compounds.
Experiments on Wistar rats showed that acute poisoning with chemicals in a dose of 0.75 LD(50) (dimethyl dichlorovinyl phosphate, sarin, VX substance, sulfur yperite, lewisite, tetraethyl lead, dichloroethane) inhibiting platelet acetylcholine esterase, alpha-naphthyl-AS-acetate esterase, and alpha-naphthyl-butyrate esterase suppressed T cell-mediated immune reactions.
Zabrodskii
P F
PF
Saratov Military Institute of Radiation, Chemical, and Biological Defense. Saratov State Medical University. pz@renet.com.ru
Germanchuk
V G
VG
Kirichuk
V F
VF
Nodel'
M L
ML
Aredakov
A N
AN
D000818:Animals; D002800:Cholinesterase Inhibitors / Q000276:immunology / Q000378:metabolism* / Q000633:toxicity; D004791:Enzyme Inhibitors / Q000378:metabolism; D004950:Esterases / Q000037:antagonists & inhibitors / Q000378:metabolism; D007107:Immune System / Q000502:physiology; D000922:Immunotoxins / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000201:enzymology / Q000276:immunology
D002800:Cholinesterase Inhibitors; D004791:Enzyme Inhibitors; D000922:Immunotoxins; D004950:Esterases