Rapid, easy cyanation of aryl bromides and chlorides using nickel salts in conjunction with microwave promotion.
We report here a fast, easy, and efficient method for the preparation of aryl nitriles from aryl bromides and chlorides. The methodology for aryl bromides involves the use of either Ni(CN)(2) or NaCN and NiBr(2). With aryl chlorides, a mix of NaCN and NiBr(2) is used and the reaction proceeds via the in situ formation of the corresponding aryl bromide. The reaction can be performed in air and is complete within 10 min.
Arvela
Riina K
RK
Department of Chemistry, King's College London, Strand, London WC2R 2LS, United Kingdom.
Leadbeater
Nicholas E
NE