Effects of the use of fibrin glue around the colonic anastomosis of the rat.
BACKGROUND
This study was aimed at examining whether the addition of fibrin glue to a sutured colonic anastomosis improves its healing or not.


METHODS
We studied the effect of adding fibrin glue on a sutured colonic anastomosis. Thirty-six Wistar rats were randomized into two groups of 18 rats each. A sutured anastomosis was performed in all rats. Fibrin glue was applied around the anastomosis of the rats of group B. Rats were sacrificed on the eighth postoperative day.


RESULTS
The rate of anastomotic leakage was found not to be significantly different between the two groups. The mean bursting pressure of the colonic anastomoses was significantly higher in group B (fibrin-treated) than in group A.


CONCLUSIONS
Fibrin glue application around a sutured anastomosis provides a safer anastomosis which is stronger than the sutured one.
Kanellos
I
I
Fourth Department of Surgery, Aristotle University of Thessaloniki, Greece. ik@hol.gr
Mantzoros
I
I
Goulimaris
I
I
Zacharakis
E
E
Zavitsanakis
A
A
Betsis
D
D
D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D016009:Chi-Square Distribution; D003082:Colectomy / Q000379:methods*; D004195:Disease Models, Animal; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D008297:Male; D011336:Probability; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D013537:Sutures; D013718:Tensile Strength
D015718:Fibrin Tissue Adhesive