Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract: part II.
Hepatoprotective activity of Azadirachta indica leaf extract against paracetamol induced hepatic damage in rats has already been reported. In the present investigation effects of Azadirachta indica leaf extract on blood and liver glutathione, Na+K(+)-ATPase activity and thiobarbutiric acid reactive substances against paracetamol induced hepatic damage in rats have been studied with a view to elucidate possible mechanism behind its hepatoprotective action. It was interesting to observe that Azadirachta indica leaf extract has reversal effects on the levels of above mentioned parameters in paracetamol hepatotoxicity. Possible mechanism behind the results are discussed.
Chattopadhyay
R R
RR
Biometry Research Unit, Indian Statistical Institute, 203, Barrackpore Trunk Road, Kolkata 700 108, India. rabi@isical.ac.in
D000082:Acetaminophen; D000818:Animals; D031601:Azadirachta / Q000737:chemistry*; D005978:Glutathione / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D000082:Acetaminophen; D005978:Glutathione