title: Otitis and respiratory distress episodes following a respiratory syncytial virus infection.
abstract: OBJECTIVE
  To document, over two consecutive respiratory syncytial virus (RSV) seasons, the occurrence of acute otitis media (AOM) and recurrence of respiratory distress in children < 2 years of age hospitalized for respiratory distress.
  
  
  METHODS
  Patients were examined during hospitalization and at 6 weeks and 6 months after discharge. RSV testing was performed on all patients, and hospitalized patients were evaluated daily for the occurrence of AOM.
  
  
  RESULTS
  In total, 347 children were enrolled; 54.8% were RSV positive, and 45.2% were RSV negative. Children were most frequently diagnosed as having bronchiolitis (71.9%) or asthmatic bronchitis (17.9%); other diagnoses included pneumonia, laryngitis, and rhinitis. During hospitalization, AOM was diagnosed in 16.8% of RSV-positive versus 8.3% of RSV-negative children (P < 0.05). Six weeks after discharge, AOM was reported in 10.4% of RSV-positive as compared with 5.8% of RSV-negative patients. Six months later, AOM was reported in 2.9% of the RSV-positive and 7.6% of the RSV-negative patients. A second episode of acute respiratory distress, which either required (9) or did not require (35) hospitalization, occurred in 18.4% of the total population, with similar proportions of RSV-positive and RSV-negative children (17% versus 18.6%).
  
  
  CONCLUSIONS
  We conclude that RSV appears to be an important contributing factor for the occurrence of AOM in young children hospitalized with respiratory distress. The occurrence of a second episode of acute respiratory distress did not appear to correlate with the previous RSV infection, but longer-term follow-up is required.
authors: Second Department of Pediatrics, University of Athens, P. & A. Kyriakou Children's Hospital, Athens, Greece. kafetzis@ath.forthnet.gr
authors: D A
authors: DA
authors: Kafetzis
authors: H
authors: H
authors: Astra
authors: M
authors: M
authors: Tsolia
authors: G
authors: G
authors: Liapi
authors: J
authors: J
authors: Mathioudakis
authors: K
authors: K
authors: Kallergi
mesh_terms: D002675:Child, Preschool; D005260:Female; D006115:Greece; D006760:Hospitalization; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010033:Otitis Media / Q000150:complications* / Q000821:virology; D011446:Prospective Studies; D012008:Recurrence; D018357:Respiratory Syncytial Virus Infections / Q000150:complications* / Q000821:virology; D018113:Respiratory Syncytial Virus, Human / Q000254:growth & development*; D012141:Respiratory Tract Infections / Q000150:complications* / Q000821:virology