Determination of adipose tissue blood flow with local 133Xe clearance. Evaluation of a new labelling technique.
Adipose tissue blood flow was measured in six healthy, non-obese subjects with the xenon wash-out technique after labelling of the tissue by either injection of 133Xe dissolved in isotonic sodium chloride (water depot) or injection of 133Xe in gas form (gas depot). The wash-out rates were registered from four depots simultaneously. Two depots were placed above the umbilicus, and two depots were placed below the umbilicus in the abdominal, subcutaneous adipose tissue. A water depot and a gas depot were placed in the two positions, respectively. It was not possible to demonstrate any difference between the wash-out rates registered from the two depot types, and it was also not possible to demonstrate any difference between the changes in wash-out rates induced by an oral glucose load. Similarly, the tissue distribution of the water and the gas depots appeared to be similar as registered by a gamma camera. It is concluded that that the two tissue labelling modes give identical results. However, there are significant regional differences in the wash-out rates of xenon from subcutaneous, abdominal adipose tissue, the wash-out rates from infraumbilical depots being about 20% lower than from the supraumbilical depots.
Simonsen
Lene
L
Department of Clinical Physiology and Nuclear Medicine, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.
Enevoldsen
Lotte H
LH
Bülow
Jens
J
D000005:Abdomen / Q000098:blood supply / Q000000981:diagnostic imaging; D000273:Adipose Tissue / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000378:metabolism; D000328:Adult; D005260:Female; D006801:Humans; D007553:Isotope Labeling / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011865:Radioisotope Dilution Technique; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D014980:Xenon Radioisotopes / Q000493:pharmacokinetics
D019275:Radiopharmaceuticals; D014980:Xenon Radioisotopes