Expression of class mu glutathione-S-transferase in human liver and its association with hepatopathies.
We studied the distribution of GSTM1 phenotypes in 611 individuals from an ethnically mixed sample of the Brazilian population who died from various causes. No influence of age, gender, or ethnicity was detected on the phenotypic distribution. In a sub-sample of 66 alcoholic individuals compared with 399 non-alcoholics there was almost a doubling of the odds ratio for GSTM1(0) individuals in the alcoholic category. The incidence of hepatopathies was higher in this group as well, and we observed a significant association of the null phenotype with cirrhosis. An excess of null phenotypes (374/611) was observed, and the allelic distribution was: GSTM1*A = 0.168, *B = 0.089, and *0 (null) = 0.743.
Engracia
V
V
Centro de Pesquisa em Medicina Tropical (CEPEM), Caixa Postal 87, Porto Velho, RO, Brazil.
Leite
M M B S
MM
Pagotto
R C
RC
Zucoloto
S
S
Barbosa
C A A
CA
Mestriner
M A
MA
D000437:Alcoholism / Q000201:enzymology / Q000208:ethnology / Q000235:genetics; D001938:Brazil; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008107:Liver Diseases / Q000201:enzymology* / Q000208:ethnology / Q000235:genetics; D008297:Male; D016017:Odds Ratio; D010641:Phenotype
D005982:Glutathione Transferase