title: Genomic and proteomic analysis of multiple sclerosis. Opinion.
abstract: Multiple sclerosis (MS) and other autoimmune diseases result from the dysregulation of genetic and proteomic programs. In MS, the loss of immune homeostasis leads to aberrant targeting and destruction of the myelin sheath, which manifests as the clinical syndrome of MS. The advent of technologies to perform large-scale analysis of mRNA transcript and protein expression will transform our understanding of the mechanisms underlying the initiation and progression of MS, and will yield new targets for therapeutic intervention.
authors: Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA. wrobins@stanford.edu
authors: William H
authors: WH
authors: Robinson
authors: Paul J
authors: PJ
authors: Utz
authors: Lawrence
authors: L
authors: Steinman
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000378:metabolism; D015894:Genome, Human; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics* / Q000378:metabolism*; D020543:Proteome; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D020543:Proteome; D012333:RNA, Messenger