Mechanisms of pathogenesis: evasion of killing by polymorphonuclear leukocytes.
Few microorganisms evade killing by neutrophils. Summarized here are the mechanisms used by Yersinia, group A streptococci, Helicobacter, Ehrlichia and Francisella to block phagocytosis, disrupt phagosome maturation or perturb the respiratory burst. Also discussed are mechanisms used by neutrophils to control organisms that replicate inside macrophages.
Allen
Lee-Ann H
LA
Department of Medicine and the Inflammation Program, MTF D154, University of Iowa and the VA Medical Center, 2501 Crosspark Road, Coralville, Iowa City, IA 55241, USA. lee-ann-allen@uiowa.edu
D001419:Bacteria / Q000378:metabolism / Q000472:pathogenicity*; D006801:Humans; D009504:Neutrophils / Q000276:immunology* / Q000502:physiology; D010587:Phagocytosis; D010588:Phagosomes / Q000382:microbiology / Q000502:physiology