Preliminary evaluation of antinephritis and radical scavenging activities of glabridin from Glycyrrhiza glabra.
Antinephritis activity of glabridin, a pyranoisoflavan isolated from Glycyrrhiza glabra, was evaluated after its oral administration to mice with glomerular disease (Masugi-nephritis) by measuring the urinary protein excretion, total cholesterol, serum creatinine and blood urea nitrogen levels. Administration of glabridin for 10 days (30 mg kg(-1) day(-1)) reduced the amount of urinary protein excretion from control level (100+/-23 mg/day) to a significantly lower level (47+/-4 mg/day). ESR spectroscopy demonstrated that glabridin neither produced radical, nor affected the radical intensity of sodium ascorbate, suggesting the lack of correlation between the antinephritis activity and radical scavenging activity.
Fukai
Toshio
T
Department of Physico-Chemical Analysis, School of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan. fukai@phar.toho-u.ac.jp
Satoh
Kazue
K
Nomura
Taro
T
Sakagami
Hiroshi
H
D000818:Animals; D001806:Blood Urea Nitrogen; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006035:Glycyrrhiza; D007529:Isoflavones; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009393:Nephritis / Q000188:drug therapy; D010636:Phenols / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D016166:Free Radical Scavengers; D007529:Isoflavones; D010636:Phenols; D010936:Plant Extracts; D002784:Cholesterol; D003404:Creatinine; C107601:glabridin