title: MRI lesion severity and mortality in geriatric depression.
abstract: OBJECTIVE
  The authors correlated magnetic resonance imaging (MRI) lesion severity and mortality among depressed elderly patients.
  
  
  METHODS
  They examined the association of mortality and deep white-matter hyperintensity (DWMH), periventricular hyperintensity (PVH), and subcortical gray-matter hyperintensity (SGH) ratings in 259 subjects.
  
  
  RESULTS
  DWMH and PVH were significantly associated with mortality initially, and, in final modeling, DWMH remained significant.
  
  
  CONCLUSIONS
  These findings suggest that there is a relationship between cerebrovascular disease severity and mortality among depressed patients. More studies, with larger sample sizes, comparing depressed patients and control subjects are needed to further elucidate this relationship.
authors: Department of Psychaitry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA. steff001@mc.duke.edu
authors: Robert M
authors: RM
authors: Levy
authors: David C
authors: DC
authors: Steffens
authors: Douglas R
authors: DR
authors: McQuoid
authors: James M
authors: JM
authors: Provenzale
authors: James R
authors: JR
authors: MacFall
authors: K Ranga Rama
authors: KR
authors: Krishnan
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000150:complications / Q000175:diagnosis / Q000401:mortality; D003863:Depression / Q000150:complications*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male