title: [Paroxysmal nocturnal hemoglobinuria associated with intestinal ischemia leading to small bowel perforation].
abstract: Paroxysmal nocturnal hemoglobinuria is rarely associated with intestinal complications. We report a case of paroxysmal nocturnal hemoglobinuria with small bowel ischemia leading to ileal perforation. In the literature, an ulcerative jejuno-ileitis has been reported in 6 cases of intestinal ischemia, due to thrombosis of mucosal small vessels. This disease is usually revealed by abdominal pain. Based on published cases and our observation of intestinal ischemia leading to small bowel perforation, surgery should be considered as the first-line treatment, especially when small bowel lesions are limited.
authors: Service des Maladies de l'Appareil Digestif, CHU Pontchaillou, 35033 Rennes.
authors: Vincent
authors: V
authors: Quentin
authors: Michel
authors: M
authors: Dinasquet
authors: Nathalie
authors: N
authors: Rioux-Leclercq
authors: Anne-Sophie
authors: AS
authors: de Lajarte-Thirouard
authors: Dominique
authors: D
authors: Lotrian
authors: Thierry
authors: T
authors: Lamy
authors: Marc
authors: M
authors: Bernard
authors: Damien
authors: D
authors: Olivié
authors: Michel
authors: M
authors: Gosselin
authors: Jean-François
authors: JF
authors: Bretagne
authors: Denis
authors: D
authors: Heresbach
mesh_terms: D000328:Adult; D005260:Female; D006457:Hemoglobinuria, Paroxysmal / Q000150:complications*; D006801:Humans; D007077:Ileal Diseases / Q000209:etiology*; D007416:Intestinal Perforation / Q000209:etiology*; D007421:Intestine, Small / Q000098:blood supply*; D007511:Ischemia / Q000150:complications*