[Effect of cimetidine with chemotherapy on stage IV colorectal cancer].
We herein report the result of a prospective study to investigate the efficacy of cimetidine administration in conjunction with chemotherapy for stage IV colorectal cancer. Sixty-two patients treated with Leucovorin/5-fluorouracil therapy were enrolled from 1996 to 2000. Both groups were well matched for pre-treatment characteristics. There was no difference in survival in cur B patients. However, the cimetidine group had significantly prolonged survival in the patients with cur C or non-resectable carcinoma. This study suggests that cimetidine treatment may improve the survival of patients with non-curative surgery for stage IV colorectal cancer.
Yoshimatsu
Kazuhiko
K
Dept. of Surgery, Tokyo Women's Medical University Daini Hospital.
Ishibashi
Keiichiro
K
Hashimoto
Masahiko
M
Umehara
Arihiro
A
Yokomizo
Hajime
H
Yoshida
Kiyohito
K
Fujimoto
Takashi
T
Iwasaki
Kiyo
K
Ogawa
Kenji
K
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002927:Cimetidine / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009366:Neoplasm Seeding; D011446:Prospective Studies; D015996:Survival Rate
D000276:Adjuvants, Immunologic; D002927:Cimetidine; D002955:Leucovorin; D005472:Fluorouracil