Mitochondrial abnormalities and oxidative imbalance in neurodegenerative disease.
An increasing body of evidence now suggests the involvement of mitochondrial abnormalities in the etiology of neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer disease. In this Perspective, we describe a recent study that shows that treatment of human patients with the antioxidant coenzyme Q(10'), which functions in concert with certain mitochondrial enzymes, reduced the worsening of symptoms associated with PD. These findings are consistent with the hypothesis that mitochondrial dysfunction plays a role in the pathogenesis of PD and that treatments that target mitochondrial biochemistry might ameliorate the functional decline observed in patients suffering from PD.
Ogawa
Osamu
O
Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
Zhu
Xiongwei
X
Perry
George
G
Smith
Mark A
MA
D003067:Coenzymes; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D010300:Parkinson Disease / Q000188:drug therapy* / Q000378:metabolism*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use*
D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10; D010100:Oxygen