Cytotoxic activity of Ozoroa insignis from Zimbabwe.
The crude methanol bark extract of the Zimbabwean medicinal plant, Ozoroa insignis, showed in-vitro cytotoxic activity against Hep-G2 (human hepatocellular carcinoma), MDA-MB-231 (human mammary adenocarcinoma), and 5637 (human primary bladder carcinoma). Bioactivity-directed chromatographic separation led to isolation of anacardic acid and ginkgoic acid as the cytotoxic components.
Rea
Angela I
AI
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.
Schmidt
Jennifer M
JM
Setzer
William N
WN
Sibanda
Samson
S
Taylor
Catherine
C
Gwebu
Ephraim T
ET
D027926:Anacardiaceae; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D006801:Humans; D016488:Medicine, African Traditional; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D015030:Zimbabwe
D000970:Antineoplastic Agents; D010936:Plant Extracts