title: Plasma levels of coagulation inhibitors, fibrinolytic markers and platelet-derived growth factor-AB in patients with failed hip prosthesis.
abstract: We studied the plasma levels of coagulation inhibitors, of fibrinolysis and PDGF-AB, in patients with aseptic loosening of the hip replacement. 23 patients having loose hip prostheses were compared to patients having 15 stable hip prostheses, and 26 undergoing primary hip replacement. The levels of the coagulation inhibitors antithrombin III and protein C were determined by chromogenic assays. Fibrinolysis was evaluated by the changes in fibrin degradation products (D-dimer), determined by enzyme immunoassay, and in the plasminogen activator inhibitor-1 (PAl-1), by enzymatic assay. PDGF-AB was determined by enzyme immunoassay. In patients with failed prostheses, we found fibrinolysis activation, as shown by a statistically significant increase in D-dimer and a significant decrease of PAI-1. No significant differences were obseved in antithrombin III, protein C, and PDGF-AB. PAI-1 and D-dimer assays in failed prostheses may be useful for the pathogenetic evaluation, because the continuous inflammatory stimulus associated with fibrin deposition may also affect the systemic levels.
authors: Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituti Ortopedici Rizzoli, Bologna, Italy. elisabetta.cenni@ior.it
authors: Elisabetta
authors: E
authors: Cenni
authors: Lucia
authors: L
authors: Savarino
authors: Nicola
authors: N
authors: Baldini
authors: Roberto
authors: R
authors: Rotini
authors: Alessandro
authors: A
authors: Marinelli
authors: Michele
authors: M
authors: Mieti
authors: Armando
authors: A
authors: Giunti
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000990:Antithrombin III / Q000032:analysis*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000032:analysis*; D011475:Prosthesis Failure; D011486:Protein C / Q000032:analysis*; D011994:Recombinant Proteins / Q000032:analysis*
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D010982:Platelet-Derived Growth Factor; D011486:Protein C; D011994:Recombinant Proteins; C095477:platelet-derived growth factor AB; D000990:Antithrombin III