Pure red cell aplasia with the onset of graft versus host disease.
Pure red cell aplasia (PRCA) occurred in the fourth month after an ABO-compatible nonmyeloablative allograft coincident with the cessation of immunosuppression and the onset of limited chronic GVHD. No secondary causes could be identified. Erythropoiesis was restored promptly and durably with the resumption of immunosuppression. A clonal T cell receptor gamma rearrangement was detected in peripheral blood lymphocytes prior to the onset of PRCA. PRCA should be added to the list of immunohaematological complications of GVHD.
Grigg
A P
AP
Diagnostic Haematology Department, The Royal Melbourne Hospital, Parkville, Australia. andrew.grigg@mh.org.au
Juneja
S K
SK
D000017:ABO Blood-Group System; D019675:Genes, T-Cell Receptor gamma; D006086:Graft vs Host Disease / Q000150:complications*; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D008875:Middle Aged; D012010:Red-Cell Aplasia, Pure / Q000209:etiology* / Q000473:pathology
D000017:ABO Blood-Group System