title: Minor diterpenoids from cascarilla (Croton eluteria Bennet) and evaluation of the cascarilla extract and cascarillin effects on gastric acid secretion.
abstract: Three new diterpenoids belonging to the clerodane (2-3) and halimane (4) structural types have been isolated from the bark of Croton eluteria Bennet, commonly known as cascarilla. Their structures have been fully characterized by spectroscopic means. Cascarilla extract and its major component, cascarillin, were found to significantly increase histamine-induced gastric acid secretion in the mouse stomach. These preliminary results provide the first rationale for the use of cascarilla in bitter preparations aimed at improving digestion.
authors: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy.
authors: Giovanni
authors: G
authors: Appendino
authors: Francesca
authors: F
authors: Borrelli
authors: Raffaele
authors: R
authors: Capasso
authors: Claudio
authors: C
authors: Campagnuolo
authors: Ernesto
authors: E
authors: Fattorusso
authors: Francesca
authors: F
authors: Petrucci
authors: Orazio
authors: O
authors: Taglialatela-Scafati
mesh_terms: D000818:Animals; D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000737:chemistry*
chemical_list: D004224:Diterpenes; D010936:Plant Extracts; D006632:Histamine