Transcription initiation at its most basic level.
The structure of the initiator binding protein from the primitive eukaryote Trichomonas vaginalis reveals how a single protein can orchestrate promoter recognition, RNA polymerase II recruitment, and start site selection, and provides an evolutionary link with transcription initiation in higher eukaryotes.
Marmorstein
Ronen
R
The Wistar Institute and the Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA.
D000818:Animals; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism*; D008958:Models, Molecular; D011401:Promoter Regions, Genetic / Q000235:genetics; D011487:Protein Conformation; D015800:Protozoan Proteins / Q000737:chemistry* / Q000378:metabolism*; D012319:RNA Polymerase II / Q000378:metabolism; D013379:Substrate Specificity; D024363:Transcription Initiation Site; D014158:Transcription, Genetic / Q000235:genetics*; D014246:Trichomonas vaginalis / Q000737:chemistry* / Q000235:genetics*
D004268:DNA-Binding Proteins; C438871:IBP39 protein, Trichomonas vaginalis; D015800:Protozoan Proteins; D004247:DNA; D012319:RNA Polymerase II