title: Nonreplication of the association between ab-ridge count and cerebral structural measures in schizophrenia.
abstract: The origins of cerebral abnormalities in psychotic patients remain unknown. Dermatoglyphics are suitable markers of prenatal injury due to their fetal ontogenesis and their susceptibility to some of the factors that also affect cerebral development. In a previous study, positive associations between brain volumetric measures and a dermatoglyphic marker, the ab-ridge count, were reported. The present study is an attempt to replicate that finding in an independent sample. Magnetic resonance imaging (MRI) scans and dermatoglyphic measures were available for 29 schizophrenia patients (Research Diagnostic Criteria [RDC] criteria) and 26 unrelated healthy controls. The images were processed using an automated procedure, yielding volumes of total grey matter, white matter, cerebrospinal fluid (CSF), and total brain volume. The ab-ridge count was not positively associated with brain volumes in either patients or controls. The present findings do not support the hypothesis that the changes in brain volume seen in patients with schizophrenia are of prenatal origin.
authors: Unitat d'Antropologia, Facultat de Biologia, Universitat de Barcelona, Spain.
authors: Araceli
authors: A
authors: Rosa
authors: Machteld
authors: M
authors: Marcelis
authors: John
authors: J
authors: Suckling
authors: Paul
authors: P
authors: Hofman
authors: Ed
authors: E
authors: Bullmore
authors: Philippe
authors: P
authors: Delespaul
authors: Lourdes
authors: L
authors: Fañanás
authors: Jim
authors: J
authors: van Os
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000002:abnormalities*; D003878:Dermatoglyphics / Q000145:classification*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000175:diagnosis* / Q000453:epidemiology*