Effect of acute progestational hypoxia on the content of biogenic amines in the brain of albino rat pups: Peptide correction.
We studied the effect of exposure to acute hypobaric hypoxia in the progestational period on the content of biogenic amines in the brainstem and cerebral cortex in rat pups of different age. The possibility of correcting hypoxia-induced changes with regulatory peptides was evaluated. We found that early antenatal hypoxia disturbs maturation of catecholaminergic systems in the brain. It should be emphasized that the differences from the control varied depending on the age of rat pups. Single intranasal administration of Semax heptapeptides and beta-casomorphine-7 to pregnant females prevented changes in the content of biogenic amines in CNS of the offspring during postnatal ontogeny.
Maslova
M V
MV
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University. maslova_masha@mail.ru
Graf
A V
AV
Sokolova
N A
NA
Goncharenko
E N
EN
Shestakova
S V
SV
Kudryashova
N Yu
NY
Andreeva
L A
LA
D000375:Aging / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001274:Atmospheric Pressure; D001679:Biogenic Amines / Q000737:chemistry / Q000378:metabolism*; D001923:Brain Chemistry; D001933:Brain Stem / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism*; D005260:Female; D000860:Hypoxia / Q000378:metabolism*; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats
D001679:Biogenic Amines; D010455:Peptides