title: Noncovalent inhibitors of human leukocyte elastase based on the 4-imidazolidinone scaffold.
abstract: A central problem associated with the design of enzyme inhibitors in general, and serine protease inhibitors in particular, is the identification of templates capable of binding to the active site of an enzyme in a predictable and substrate-like fashion, orienting appended recognition elements in a correct spatial relationship so that favorable binding interactions with multiple sites are achieved. Described herein for the first time is the design of noncovalent inhibitors of human leukocyte elastase that employs a functionalized 4-imidazolidinone scaffold.
authors: Department of Chemistry, Wichita State University, Wichita, KS 67260, USA.
authors: Liuqing
authors: L
authors: Wei
authors: Xiangdong
authors: X
authors: Gan
authors: Jiaying
authors: J
authors: Zhong
authors: Kevin R
authors: KR
authors: Alliston
authors: William C
authors: WC
authors: Groutas
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy
chemical_list: D004791:Enzyme Inhibitors; D007093:Imidazoles; D019272:Leukocyte Elastase