title: The contribution made by Schistosoma infection to non-traumatic disorders of the spinal cord in Malawi.
abstract: In Malawi, although schistosomal myelopathy has been reported in visitors from overseas who have swum in Lake Malawi, the incidence of this disorder in local residents has never been investigated. Consecutive patients with non-traumatic disorders of the spinal cord were therefore recruited in a hospital and a rehabilitation centre in Blantyre. Of the 33 patients investigated, 16 were presumed to be cases of schistosomal myelopathy as they had the markers of past or current schistosomiasis and apparently no other conditions that could explain their clinical features. There was microscopical and/or immunodiagnostic evidence indicating that eight of these presumptive cases had active schistosomiasis. All 16 presumptive cases had symptoms that were similar to those of 177 presumptive or proven cases of neuroschistosomiasis described in the scientific literature. Following antihelminthic treatment, eight of the presumptive cases showed marked improvement. Schistosomal myelopathy seems to occur relatively frequently in Malawi. Early treatment with praziquantel is strongly recommended for all patients with unexplained myelopathy and a history of exposure to schistosome cercariae.
authors: Department of Parasitology, Centre for Infectious Diseases, Leids Universitair Medisch Centrum, L4-Q, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
authors: C W A
authors: CW
authors: Naus
authors: J
authors: J
authors: Chipwete
authors: L G
authors: LG
authors: Visser
authors: E E
authors: EE
authors: Zijlstra
authors: L
authors: L
authors: van Lieshout
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000909:Antibodies, Helminth / Q000032:analysis; D000947:Antigens, Helminth / Q000032:analysis; D002648:Child; D005260:Female; D006801:Humans; D008295:Malawi; D008297:Male; D008581:Meningitis / Q000469:parasitology; D008875:Middle Aged; D015995:Prevalence; D012552:Schistosomiasis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013118:Spinal Cord Diseases / Q000209:etiology*
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth