Design progress of the ultracompact integrated heart lung assist device--part 1: effect of vaned diffusers on gas-transfer performances.
The integrated heart lung assist device (IHLAD) has been developed to overcome the problems of currently available extracorporeal membrane oxygenation devices. The integrated structure of a centrifugal blood pump and cylindrical bundle of polyolefin hollow-fibers has allowed a remarkably compact size for the device. This study deals with the design change of the IHLAD that added to the vaned diffuser between the impeller of the centrifugal pump and the hollow-fiber bundle with a view to enhancing the gas-transfer performance. Ex vivo gas-transfer performance tests were carried out, as well as hydrodynamic characteristics and hemolysis test using fresh goat blood. The oxygen transfer rate was generally improved, and the carbon dioxide removal rate was slightly improved. Intolerable amount of hemolysis (index of hemolysis= 0.177) was caused by the IHLAD, which must be resolved by improving the design in the future.
Tsukiya
Tomonori
T
Department of Artificial Organs, Research Institute of National Cardiovascular Center, Suita, Osaka, Japan. tsukiya@ri.ncvc.go.jp
Tatsumi
Eisuke
E
Nishinaka
Tomohiro
T
Katagiri
Nobumasa
N
Takewa
Yoshiaki
Y
Ohnishi
Hiroyuki
H
Oshikawa
Mitsuo
M
Shioya
Kyoko
K
Mizuno
Toshihide
T
Taenaka
Yoshiyuki
Y
Takano
Hisateru
H
Kitamura
Soichiro
S
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004867:Equipment Design; D006041:Goats; D006353:Heart-Assist Devices; D006355:Heart-Lung Machine; D008422:Materials Testing; D008567:Membranes, Artificial; D010100:Oxygen; D010107:Oxygenators, Membrane
D008567:Membranes, Artificial; D002245:Carbon Dioxide; D010100:Oxygen