title: Age-related memory impairment. Is the cure worse than the disease?
abstract: Aging impairs multiple memory systems. The neurochemical substrates of normal memory differ between memory systems. In this issue of Neuron, Ramos et al. find that activation of protein kinase A, which has been reported to improve hippocampal-dependent spatial memory in aged animals, has the opposite effect on prefrontal cortex-dependent working memory in aged animals.
authors: Department of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA 02138, USA.
authors: Mark G
authors: MG
authors: Baxter
mesh_terms: D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000187:drug effects / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology* / Q000503:physiopathology; D006801:Humans; D008569:Memory Disorders / Q000188:drug therapy / Q000201:enzymology* / Q000503:physiopathology; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology; D018697:Nootropic Agents / Q000494:pharmacology; D017397:Prefrontal Cortex / Q000187:drug effects / Q000201:enzymology* / Q000503:physiopathology
chemical_list: D018697:Nootropic Agents; D017868:Cyclic AMP-Dependent Protein Kinases