Regulation of ion channel structure and function by reactive oxygen-nitrogen species.
Ion channels subserve diverse cellular functions. Reactive oxygen and nitrogen species modulate ion channel function by a number of mechanisms including 1) transcriptional regulation of gene expression, 2) posttranslational modifications of channel proteins, i.e. nitrosylation, nitration, and oxidation of key amino acid residues, 3) by altering the gain in other signaling pathways that may in turn lead to changes in channel activity or channel gene expression, and 4) by modulating trafficking or turnover of channel proteins, as typified by oxygen radical activation of NF-kappa B, with subsequent changes in proteasomal degradation of channel degradation. Regardless of the mechanism, as was discussed in a symposium at the 2003 Experimental Biology Meeting in San Diego, CA, changes in the cellular level of reactive oxygen and nitrogen species can have profound effects on the activity of ion channels and cellular function.
Matalon
Sadis
S
Department of Physiology, University of Alabama at Birmingham, Rm. 224, BMR II, 901 S. 19th St., Birmingham, AL 35205-3703, USA. Sadis@uab.edu
Hardiman
Karin M
KM
Jain
Lucky
L
Eaton
Douglas C
DC
Kotlikoff
Michael
M
Eu
Jerry P
JP
Sun
Junhui
J
Meissner
Gerhard
G
Stamler
Jonathan S
JS
D000818:Animals; D006801:Humans; D007473:Ion Channels / Q000235:genetics / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000378:metabolism; D026361:Reactive Nitrogen Species / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D020545:Respiratory Mucosa / Q000378:metabolism*
D007473:Ion Channels; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species