title: Aggressive angiomyxoma in the scrotum expressing androgen and progesterone receptors.
abstract: Aggressive angiomyxoma is a rare benign mesenchymal myxoid tumor that arises from the pelvic soft tissues and perineum in relatively young females. This tumor has the ability to infiltrate locally and has a high risk of local recurrence after extirpation, but no potential to metastasize. We report here a rare case of aggressive angiomyxoma that developed in the scrotum of a 47-year-old male. Immunostaining of the resected specimen revealed that the tumor cell nuclei stained strongly and diffusely for androgen receptors (80% of the tumor cells), and moderately and partly for progesterone receptors (20% of the tumor cells). However, staining was negative for estrogen receptors. It is highly suggested that the growth of aggressive angiomyxoma in males may depend on androgen manipulation, contrary to its frequent and close association with estrogen receptor expression, which has been reported in females.
authors: Department of Urology, Nara Medical University, Nara, Japan.
authors: Yoshitomo
authors: Y
authors: Chihara
authors: Kiyohide
authors: K
authors: Fujimoto
authors: Satishi
authors: S
authors: Takada
authors: Akihide
authors: A
authors: Hirayama
authors: Masaki
authors: M
authors: Cho
authors: Katsunori
authors: K
authors: Yoshida
authors: Seiichiro
authors: S
authors: Ozono
authors: Yoshihiko
authors: Y
authors: Hirao
mesh_terms: D005834:Genital Neoplasms, Male / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009232:Myxoma / Q000378:metabolism*; D011944:Receptors, Androgen / Q000096:biosynthesis*; D011980:Receptors, Progesterone / Q000096:biosynthesis*; D012611:Scrotum
chemical_list: D011944:Receptors, Androgen; D011980:Receptors, Progesterone