Acute cortisol administration triggers craving in individuals with cocaine dependence.
Stress is often mentioned as a factor in the development of drug abuse. Twelve cocaine dependent individuals were administered a stress hormone, cortisol, along with cocaine and saline via intravenous boluses, in a double-blind, counterbalanced fashion. Self-reports of mood states were collected prior to, during, and 20 minutes after each bolus was administered. Cortisol produced significant increases in craving while cocaine significantly elevated all subjective ratings (ie, craving, high, rush, and low). These pilot data suggest that cortisol can induce a state that is associated with drug abuse.
Elman
Igor
I
Behavioral Psychopharmacology Research Laboratory, Harvard Medical School/McLean Hospital, Belmont, MA 02478, USA. ielman@partners.org
Lukas
Scott E
SE
Karlsgodt
Katherine H
KH
Gasic
Gregory P
GP
Breiter
Hans C
HC
D000328:Adult; D016739:Behavior, Addictive / Q000139:chemically induced*; D019970:Cocaine-Related Disorders / Q000150:complications*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D007275:Injections, Intravenous; D008297:Male; D010865:Pilot Projects; D012720:Severity of Illness Index; D013315:Stress, Psychological / Q000150:complications*
D006854:Hydrocortisone