title: Epidemiological evidence of an association between SLC6A2 gene polymorphism and hypertension.
abstract: Selective blockade of the norepinephrine transporter with reboxetine has been reported to induce a slight but significant increase in blood pressure. This study was designed to examine the relation of genetic variants of the norepinephrine transporter gene (solute carrier family 6, member 2; SLC6A2) with hypertension in a Japanese population. We genotyped five genetic variants of SLC6A2, three in the promoter region and two in the intronic sequence, in 1,950 subjects recruited from the Suita study. One of the variants, an A > G polymorphism in the promoter region (Promoter 3 polymorphism), was found to be associated with hypertension. Multiple logistic analysis indicated that sex (p = 0.0223), age (p < 0.0001), body mass index (p < 0.0001), alcohol consumption (p = 0.0002), and the Promoter 3 genotype (AA = 1, AG + GG = 2) (p = 0.0090) were predictive of hypertensive status. The odds ratio of the AG + GG genotypes for hypertension was 1.35 (95% confidence interval: 1.08-1.69) over the AA genotype. SLC6A2 may be one of the genes that contribute to hypertension in Japanese. To our knowledge, this is the first report to detect associations between SLC6A2 genetic variants and blood pressure.
authors: National Cardiovascular Center, Suita, Japan.
authors: Koh
authors: K
authors: Ono
authors: Yoshitaka
authors: Y
authors: Iwanaga
authors: Toshifumi
authors: T
authors: Mannami
authors: Yoshihiro
authors: Y
authors: Kokubo
authors: Hitonobu
authors: H
authors: Tomoike
authors: Kazuo
authors: K
authors: Komamura
authors: Keisuke
authors: K
authors: Shioji
authors: Naomi
authors: N
authors: Yasui
authors: Naomi
authors: N
authors: Tago
authors: Naoharu
authors: N
authors: Iwai
mesh_terms: D001794:Blood Pressure / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology* / Q000235:genetics*; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D050484:Norepinephrine Plasma Membrane Transport Proteins; D011110:Polymorphism, Genetic; D027981:Symporters / Q000235:genetics*
chemical_list: D050484:Norepinephrine Plasma Membrane Transport Proteins; C493227:SLC6A2 protein, human; D027981:Symporters