title: Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters.
abstract: A series of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters was synthesized and their antimicrobial activity was established. These derivatives exhibit increased activity against VanB resistant strains of bacteria equipotent with that observed with sensitive bacteria.
authors: Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
authors: Casey C
authors: CC
authors: McComas
authors: Brendan M
authors: BM
authors: Crowley
authors: Inkyu
authors: I
authors: Hwang
authors: Dale L
authors: DL
authors: Boger
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects; D008738:Methyl Ethers / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D012310:Ristocetin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D017334:Teicoplanin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D020713:Vancomycin Resistance
chemical_list: D000890:Anti-Infective Agents; D008738:Methyl Ethers; D012310:Ristocetin; D017334:Teicoplanin; D014640:Vancomycin