[Determination of diazepine derivatives: alprazolam, medazepam, chlordiazepoxid mixture by high performance liquid chromatography].
The aim of this research was to determine possibility of qualitative analysis of diazepine derivatives: alprazolam, medazepam, chlordiazepoxid in the mixture. The high performance liquid chromatography was used for the investigation, the reagents--tablets of alprazolam, medazepam, chlordiazepoxid. It was found out that the most acceptable eluent for the analysis of the mixture by high pressure liquid chromatography is phosphate buffer, containing 0.02 M penthanesulfonic acid:etannitrile (55:45) (pH=3.5). The optimal wavelength for identification of the drugs in the mixture is 254 nm.
Zevzikoviene
Augusta
A
Department of Analytical and Toxicological Chemistry, Kaunas University of Medicine, Kaunas, Lithuania. augusta@kaunas.init.lt
Zevzikovas
Andrejus
A
Bertulis
Albertas
A
D000525:Alprazolam / Q000032:analysis; D014151:Anti-Anxiety Agents / Q000032:analysis*; D001569:Benzodiazepines / Q000032:analysis*; D002021:Buffers; D002707:Chlordiazepoxide / Q000032:analysis; D002851:Chromatography, High Pressure Liquid; D003627:Data Interpretation, Statistical; D008472:Medazepam / Q000032:analysis
D014151:Anti-Anxiety Agents; D002021:Buffers; D001569:Benzodiazepines; D002707:Chlordiazepoxide; D008472:Medazepam; D000525:Alprazolam