title: Modified jatrophane diterpenes as modulators of multidrug resistance from Euphorbia dendroides L.
abstract: The new diterpenoids terracinolides J-L (1-3), 13alpha-OH terracinolide F (8), abeodendroidin F (11) and epiabeodendroidin F (12) have been identified from Euphorbia dendroides L. The new compounds and six co-occurring known terracinolides were tested as inhibitors of the drug-efflux activity of P-glycoprotein from cancer cells. The results were used to extend the structure-activity relationships established for this class of compounds highlighting the relevance of substitution at positions 2, 3, 6, and 15 and disclosing a remarkable tolerance toward connectivity changes in the terpenoid core.
authors: Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli 'Federico II', Via D. Montesano 49, I-80131, Napoli, Italy.
authors: Gabriella
authors: G
authors: Corea
authors: Ernesto
authors: E
authors: Fattorusso
authors: Virginia
authors: V
authors: Lanzotti
authors: Orazio
authors: O
authors: Taglialatela-Scafati
authors: Giovanni
authors: G
authors: Appendino
authors: Mauro
authors: M
authors: Ballero
authors: Pierre Noël
authors: PN
authors: Simon
authors: Charles
authors: C
authors: Dumontet
authors: Attilio
authors: A
authors: Di Pietro
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000037:antagonists & inhibitors; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000494:pharmacology*; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D028481:Euphorbia / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D004224:Diterpenes