title: Isolated teratozoospermia and intrauterine insemination.
abstract: OBJECTIVE
  This study tests the hypothesis that IUI treatment in cases with isolated teratozoospermia (<10% normal forms using strict criteria, normal motility and normal count), results in a lower cumulative live birth rate compared to cases with normozoospermia.
  
  
  METHODS
  A retrospective cohort study.
  
  
  METHODS
  An academic fertility center.
  
  
  METHODS
  Eight hundred seventy-two IUI cycles in 440 couples were analyzed.
  
  
  METHODS
  Couples (n = 440) were classified in three groups: normozoospermia (n = 213), isolated teratozoospermia (n = 104), and male factor infertility (n = 123).
  
  
  METHODS
  Live birth rate per cycle and cumulative live birth rate (CLBR).
  
  
  RESULTS
  The three groups were similar with regard to female age, female infertility factors, and ovarian response after hormonal stimulation. The overall CLBR after four cycles was 41.5%, and was significantly increased in the normozoospermic group (52.8%) when compared to the isolated teratozoospermia group (33.4%) and the male factor infertility group (31.4%).
  
  
  CONCLUSIONS
  This study documents for the first time that the CLBR after four IUI cycles is significantly and similarly reduced in couples with isolated teratozoospermia as in couples with other sperm defects, when compared to couples with normozoospermia. As with couples with male factor infertility, couples with isolated teratozoospermia should be counseled about other treatment options such as IVF, as the CLBR after three IVF cycles is 70%-80% in our program.
authors: Leuven University Fertility Centre, University Hospital Leuven, Leuven, Belgium. carl.spiessens@uz.kuleuven.ac.be
authors: Carl
authors: C
authors: Spiessens
authors: Dirk
authors: D
authors: Vanderschueren
authors: Christel
authors: C
authors: Meuleman
authors: Thomas
authors: T
authors: D'Hooghe
mesh_terms: D000328:Adult; D001723:Birth Rate; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000503:physiopathology; D007317:Insemination, Artificial, Homologous; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D013094:Spermatozoa / Q000002:abnormalities*