title: [The PATCHED/Sonic Hedgehog signalling pathway in superficial bladder cancer].
abstract: Superficial bladder cancer shows a high frequency of total or partial chromosome 9 losses. Loss of heterozygosity at position 9q22.3 is one of the most frequent and is associated with highly recurrent tumours. The PATCHED gene, ortholog of a gene first described in the drosophila as a segment polarity gene, is located at 9q22.3. It is a member of a signal transduction pathway and a tumour suppressor gene (TSG), involved in basal cell carcinoma. We propose PATCHED as a TSG candidate in superficial bladder cancer.
authors: Centre de recherche en cancérologie de l'Université Laval, CHUQ-L'Hôtel-Dieu de Québec, 10, rue MacMahon, G1R 2J6 Québec, Canada.
authors: Hélène
authors: H
authors: LaRue
authors: Maryse
authors: M
authors: Simoneau
authors: Tahar O
authors: TO
authors: Aboulkassim
authors: Patricia
authors: P
authors: Lemieux
authors: Johanne
authors: J
authors: Girard
authors: Sahar
authors: S
authors: Hamed
authors: Hélène
authors: H
authors: Hovington
authors: Lucie
authors: L
authors: Jeannotte
authors: Yves
authors: Y
authors: Fradet
mesh_terms: D002280:Basal Cell Carcinoma / Q000235:genetics* / Q000503:physiopathology*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D016147:Genes, Tumor Suppressor; D006801:Humans; D019656:Loss of Heterozygosity; D008565:Membrane Proteins / Q000235:genetics* / Q000494:pharmacology*; D000072079:Patched Receptors; D011956:Receptors, Cell Surface; D015398:Signal Transduction; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000503:physiopathology*
chemical_list: D008565:Membrane Proteins; D000072079:Patched Receptors; D011956:Receptors, Cell Surface