[Effect of DC therapy combined with chemotherapy in advanced cancer cases].
Dendritic cells (DC) are powerful antigen-presenting cells, and have attracted attention in recent years from the viewpoint of DC vaccine therapy against cancer. However, the existence of an immunosuppressive state in cancer individuals leads to anergy and immunotolerance, which has been reported to be caused by T cell and DC immunosuppressive subsets or cytokines such as Th2, Tc2, CD4+CD25+, DC2 and IL-10 against Th1, Tc1, DC1 and IL-12. Therefore, DC therapy could be incompatible with severe chemotherapy. Conversely, there are some reports that indicate tumor specific cytotoxicity in DC therapy could be augmentedly un exposure to tumor antigen caused by apoptosis in combination radiation or chemotherapy. In this study we examined the usefulness of DC therapy combined with chemotherapy and BRM (PSK) administration by analyzing the immunocyte subsets and cytokines as well as the combination effect. The results indicate this method can be useful in advanced cancer patients.
Kanazawa
Masashi
M
Dept. of Surgery 2, Fukushima Medical University.
Mori
Yayoi
Y
Yoshihara
Kazue
K
Iwadate
Manabu
M
Suzuki
Satoshi
S
Endoh
Yoshiyuki
Y
Takita
Ken-ichi
K
Sekikawa
Kouji
K
Takenoshita
Seiichi
S
Ogata
Takashi
T
Ohto
Hitoshi
H
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D015704:CD4 Antigens / Q000097:blood; D003110:Colonic Neoplasms / Q000276:immunology / Q000628:therapy*; D003131:Combined Modality Therapy; D016207:Cytokines / Q000097:blood; D003713:Dendritic Cells / Q000637:transplantation*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D015979:Killer Cells, Lymphokine-Activated / Q000637:transplantation; D011509:Proteoglycans / Q000008:administration & dosage*; D015375:Receptors, Interleukin-2 / Q000097:blood; D013274:Stomach Neoplasms / Q000276:immunology / Q000628:therapy*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology
D000276:Adjuvants, Immunologic; D015704:CD4 Antigens; D016207:Cytokines; D011509:Proteoglycans; D015375:Receptors, Interleukin-2; D016753:Interleukin-10; D018664:Interleukin-12; C010770:polysaccharide-K