Effects of tamoxifen therapy on the expression of p27 protein in the endometrium of women with primary breast cancer.
The cyclin-dependent kinase inhibitor, p27, has been shown to mediate cell growth arrest thereby significantly reducing the percentage of proliferating cells. It seems that p27 expression is essential for the control of normal endometrial proliferation, and reduced or absent p27 expression may be an important step in endometrial carcinogenesis. Our aim was to demonstrate the effects of tamoxifen therapy on the expression of p27 protein in the endometrium of postmenopausal breast cancer patients. Fifty-three pre- and post-tamoxifen treatment endometrium samples were examined immunohistochemically using p27 antibody. Tamoxifen therapy (20 mg/day) for 60 days increased the expression of p27 protein in the endometrium of postmenopausal breast cancer patients. We conclude that tamoxifen therapy does not seem to be directly involved in the carcinogenesis of endometrial carcinoma since the expression of p27 is not decreased.
Siufi
Adalberto Abraão
AA
Department of Gynecology, Federal University of Mato Grosso, São Paulo, Brazil.
Cotrim G  Da Silva
Ismael Dale
ID
De Cassia M  Dardes
Rita
R
Takita
Luiz Carlos
LC
Rodrigues De Lima
Geraldo
G
Gonçalves
Wagner José
WJ
D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000517:prevention & control; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D004965:Estrogen Antagonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008840:Microfilament Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D009124:Muscle Proteins; D017698:Postmenopause; D013629:Tamoxifen / Q000627:therapeutic use*; D013997:Time Factors
D018931:Antineoplastic Agents, Hormonal; D004965:Estrogen Antagonists; D008840:Microfilament Proteins; D009124:Muscle Proteins; C058992:Tagln protein, mouse; D013629:Tamoxifen