title: Cobalt-mediated macrocyclizations. Facile synthesis of 2-oxo pyridinophanes via [2 + 2 + 2] cycloaddition of alpha, omega-diynes and isocyanates.
abstract: [reaction: see text] Cobalt-mediated [2 + 2 + 2] cycloaddition of alpha,omega-diynes and isocyanates provides a direct approach to macrocyclic 2-oxopyridinophanes. This macrocyclization process, which proceeded most efficiently with aliphatic isocyanates, was conveniently performed at a moderate temperature (85 degrees C) without irradiation or syringe-pump addition.
authors: Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development, Spring House, Pennsylvania 19477-0776, USA.
authors: Llorente V R
authors: LV
authors: Boñaga
authors: Han-Cheng
authors: HC
authors: Zhang
authors: Diane A
authors: DA
authors: Gauthier
authors: Indrasena
authors: I
authors: Reddy
authors: Bruce E
authors: BE
authors: Maryanoff