[Experimental study on spermatogenic and strengthening yang action of baxian capsule].
OBJECTIVE
To discuss spermatogenic and strengthening yang action of Baxian(BX) capsule and its possible mechanism.


METHODS
Rats or mice were divided randomly into five groups: control group, Baxian groups(2.5 g/kg, 7.5 g/kg, 22.5 g/kg) and positive group. After the drug had been given for 14 days, the levels of serum testosterone and cortisol in the low-aged rats were measured by radioimmunoassay. The coefficient of the reproductive organs in rats, the quantity of sperm and interstitial cells in mice were investigated, and the change of the latency time of penis erection in castrated rats, the capture and ejaculation in normal rats were observed at the same time.


RESULTS
BX capsule could obviously raise the concentration of serum testosterone and cortisol, and the coefficient of sex organ in rats, and increase the number of sperm and interstitial cells in mice. Also, it could improve the penis erection and sexual ability of the male rats.


CONCLUSIONS
The spermatogenic and strengthening yang action of BX capsule could be attributed to the improvement of the actions of the axis of lower thalamus-hypophysis-sexual gland and the axis of lower thalamus-hypophysis-adrenal cortex.
Chen
Xiao-Ming
XM
Department of Clinical Pharmacy, Nanjing General Hospital, Nanjing Command, PLA, Nanjing, Jiangsu 210002, China.
Ni
Li
L
Li
Jin-Heng
JH
Sun
Wei-Lin
WL
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005837:Genitalia, Male / Q000187:drug effects*; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000097:blood*
D004365:Drugs, Chinese Herbal; D013739:Testosterone; D006854:Hydrocortisone