Preparation of 1-hydroxyethylidene-1,1-diphosphonic acid-intercalated layered double hydroxide and its physicochemical properties.
The intercalation of 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), which is a drug for osteoporosis, in layered double hydroxide (LDH) was examined with the goal of developing a novel drug delivery system (DDS) of HEDP. To prevent side reactions, the intercalation reaction was carried out at 0 degrees C, and at pH 4-6. The uptake of HEDP was determined as 3.5 mmol x g(-1) of LDH, and the interlayer distance increased from 7.8 to 13 A. The HEDP-release profiles into K(2)CO(3) aqueous solution and into various buffer solutions were also examined.
Nakayama
Hirokazu
H
Department of Functional Molecular Chemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakitamachi, Higashinada-ku, Kobe 658-8558 Japan. hiro@kobepharma-u.ac.jp
Takeshita
Koji
K
Tsuhako
Mitsutomo
M
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D012968:Etidronic Acid / Q000032:analysis / Q000737:chemistry* / Q000493:pharmacokinetics*; D006878:Hydroxides / Q000032:analysis / Q000737:chemistry* / Q000493:pharmacokinetics*
D006878:Hydroxides; D012968:Etidronic Acid