The influence of an improved preservation solution on prognostic factors for graft survival in pediatric liver transplantation.
We investigated the influence of Eurocollins (EC) and University of Wisconson solution (UW) on prognostic factors for graft survival after pediatric liver transplantation. The 1-year graft survival was studied for 30 patients in which 38 transplantations were performed between 1982 and 1988. We preserved 19 grafts in EC and the other 19 grafts in UW solution. For grafts preserved in EC, the median preservation time was 5 h compared to 10.8 h for grafts preserved in UW solution (P < 0.01). Graft survival at 1 year was equivalent in both groups (63%). No significant differences were observed between the two groups for the following variables: patient diagnosis, child-pugh score, age, operative time, anhepatic phase, blood loss, morbidity, ICU stay, donor age and graft survival. Multivariate analysis indicated that in the EC group anhepatic phase, blood loss and preservation time were significant predictors of graft survival whereas in the UW group, none of these factors appeared to be significant. We concluded that UW was superior to EC solution in pediatric liver transplantations because it allowed longer preservation times, the length of the anhepatic phase was less important and the tolerance for blood loss seemed to be extended.
Peeters
P M
PM
Liver Transplant Group, University Hospital Groningen, Department of Surgery, Groningen, The Netherlands.
ten Vergert
E M
EM
Pisarski
S
S
Bijleveld
C M
CM
Bleichrodt
R P
RP
Slooff
M J
MJ
D000293:Adolescent; D000328:Adult; D016063:Blood Loss, Surgical; D002648:Child; D002675:Child, Preschool; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D007223:Infant; D008099:Liver; D016031:Liver Transplantation / Q000379:methods / Q000502:physiology*; D015999:Multivariate Analysis; D019188:Organ Preservation Solutions; D011183:Postoperative Complications / Q000453:epidemiology; D011237:Predictive Value of Tests; D011379:Prognosis; D014019:Tissue Donors
D019188:Organ Preservation Solutions