Synthesis and biological evaluation of a novel phenyl substituted sydnone series as potential antitumor agents.
A series of compounds containing an N-(4'-substituted-3'-nitrophenyl)sydnone moiety with potential antitumor activity was prepared based on active analogues. The rationale behind the design of these compounds is presented along with the 4-step synthetic route to the derivatives in the 4'-position of the phenyl sydnone framework. Out of the six novel compounds, the 4'-fluoro derivative has an improved activity against all three cell lines as compared to the earlier leads.
Dunkley
Christopher S
CS
Department of Chemistry and Biochemistry, University of the Sciences in Philadelphia, PA 19104, USA.
Thoman
Charles J
CJ
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013558:Sydnones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D001555:Benzene Derivatives; D013558:Sydnones