title: Improved accuracy of hysteroembryoscopic biopsies for karyotyping early missed abortions.
abstract: OBJECTIVE
  To assess the potential of direct embryo and chorion biopsies obtained by hysteroembryoscopy for karyotyping early missed abortions.
  
  
  METHODS
  Clinical prospective descriptive study.
  
  
  METHODS
  Instituto Valenciano de Infertilidad, Valencia, Spain.
  
  
  METHODS
  Sixty-eight women (71 gestational sacs) with missed abortions. The gestational age on ultrasound was 6.3 weeks (range, 4-10 weeks).
  
  
  METHODS
  Transcervical hysteroembryoscopy before curettage.
  
  
  METHODS
  Comparison between the cytogenetic results from hysteroembryoscopic biospies and those of the curettage material.
  
  
  RESULTS
  Hysteroembryoscopic biopsies could be taken in 97.2% of the gestational sacs. Direct embryo and chorion biopsies were suitable for chromosomal analysis. Selective samples identified misdiagnoses of the conventional curettage karyotype due to maternal contaminating tissues in 22.2% of the cases. Direct hysteroembryoscopic biopsies also enabled the diagnosis of a true placental mosaicism and the study of the individual karyotype of each gestational sac in bizygotic twin missed abortions.
  
  
  CONCLUSIONS
  In early missed abortions, karyotypes from direct hysteroembryoscopic biopsies were more accurate than those from the curettage material. The finding of a 46,XX karyotype in the curettage material is not a reliable result.
authors: Instituto Valenciano de Infertilidad, Valencia, Spain. ummf@ivi.es
authors: Jaime
authors: J
authors: Ferro
authors: Ma Carmen
authors: MC
authors: Martínez
authors: Coral
authors: C
authors: Lara
authors: Antonio
authors: A
authors: Pellicer
authors: José
authors: J
authors: Remohí
authors: Vicente
authors: V
authors: Serra
mesh_terms: D000030:Abortion, Missed / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D000328:Adult; D001706:Biopsy; D002823:Chorion / Q000473:pathology; D003475:Curettage; D020732:Cytogenetic Analysis; D003951:Diagnostic Errors; D004622:Embryo, Mammalian / Q000473:pathology; D005260:Female; D005332:Fetoscopy; D006801:Humans; D015907:Hysteroscopy; D007621:Karyotyping / Q000379:methods*; D008875:Middle Aged; D009030:Mosaicism / Q000473:pathology; D010920:Placenta / Q000473:pathology; D011446:Prospective Studies; D014429:Twins, Dizygotic / Q000235:genetics