title: A substructure approach toward polymeric receptors targeting dihydrofolate reductase inhibitors. 2. Molecularly imprinted polymers against Z-l-glutamic acid showing affinity for larger molecules.
abstract: The preparation of a molecularly imprinted polymer against N-Z-L-glutamic acid using a novel bis-urea functional monomer is described. The polymer exhibits affinity for the template over N-Z-protected aspartic acid and glycine and, further, is capable of binding larger molecules, e.g., the anti-cancer drug methotrexate, containing the glutamate substructure.
authors: Institut für Anorganische Chemie und Analytische Chemie, Johannes Gutenberg Universität, Duesbergweg 10-14, D-55099, Mainz, Germany. andy@infu.uni-dortmund.de
authors: Andrew J
authors: AJ
authors: Hall
authors: Laura
authors: L
authors: Achilli
authors: Panagiotis
authors: P
authors: Manesiotis
authors: Milena
authors: M
authors: Quaglia
authors: Ersilia
authors: E
authors: De Lorenzi
authors: Börje
authors: B
authors: Sellergren
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry*; D005493:Folic Acid Antagonists / Q000737:chemistry* / Q000494:pharmacology; D018698:Glutamic Acid / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008727:Methotrexate / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry*; D013762:Tetrahydrofolate Dehydrogenase / Q000187:drug effects*
chemical_list: D004791:Enzyme Inhibitors; D005493:Folic Acid Antagonists; D011108:Polymers; D018698:Glutamic Acid; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate