title: High-resolution solid-state NMR applied to polypeptides and membrane proteins.
abstract: Solid-state NMR provides unique possibilities to study insoluble or noncrystalline molecules at the atomic level. High-resolution conditions can be established by employing magic-angle spinning at ultrahigh magnetic fields. We discuss NMR methods that make use of these experimental improvements and allow for the study of multiply or uniformly [(13)C,(15)N]-labeled polypeptides and proteins. Recent biophysical applications are reviewed.
authors: Department of NMR-Based Structural Biology, Solid-state NMR, Max-Planck-Institute for Biophysical Chemistry, 37077 Göttingen, Germany.
authors: Sorin
authors: S
authors: Luca
authors: Henrike
authors: H
authors: Heise
authors: Marc
authors: M
authors: Baldus
mesh_terms: D008565:Membrane Proteins / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation
chemical_list: D008565:Membrane Proteins; D010455:Peptides