Kidney development conserved over species: essential roles of Sall1.
The kidney develops in three stages: pronephros, mesonephros, and metanephros. Molecular mechanisms underlying these three steps are similar, and we can thus examine genetic cascades occurring during development. The induction system for pronephros in vitro has been established in Xenopus. Using this system, we isolated Sall1 that is essential for the initial step in metanephros formation. The potential mechanisms involved and future directions regarding kidney development are discussed.
Nishinakamura
Ryuichi
R
Division of Stem Cell Regulation, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan. ryuichi@ims.u-tokyo.ac.jp
D000818:Animals; D005075:Biological Evolution; D006801:Humans; D007668:Kidney / Q000196:embryology*; D008648:Mesoderm / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D009154:Mutation; D010641:Phenotype; D013045:Species Specificity; D014157:Transcription Factors / Q000378:metabolism*; D014981:Xenopus
C104146:SALL1 protein, human; C491254:Sall1 protein, mouse; D014157:Transcription Factors