Are statins indicated for the primary prevention of coronary heart disease in octogenarians? protagonist viewpoint.
Statins should be given to octogenarians for primary prevention of coronary heart disease. There is a substantial burden of disease and disability in this population that statin treatment can address in an effective manner. It has been shown that statin treatment is both effective and safe, and details of the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER) trial are reviewed. It may be useful to tease out those at particularly high risk who would benefit from statin treatment. In this regard, a low high-density lipoprotein cholesterol level, high-sensitivity C-reactive protein level, and subclinical measures of atherosclerosis may be particularly useful.
Stone
Neil J
NJ
The Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. n-stone@northwestern.edu
D000368:Aged; D000369:Aged, 80 and over; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002097:C-Reactive Protein / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000517:prevention & control*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D011322:Primary Prevention; D012307:Risk Factors
D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002097:C-Reactive Protein