Tritiation of nonpeptide substance P antagonist CP-96,345 and its azido analogue. Synthetic and characterization details.
CP-96,345 (1) was the first nonpeptide antagonist discovered for the SP receptor and [3H] CP-96,345 was required to study the mechanism of receptor action. The radioligand was prepared at high specific activity by catalytic dehalogenation of a dibrominated precursor and this same approach was also used to prepare a photoaffinity analogue.
Egan
Judith A
JA
PerkinElmer Life and Analytical Sciences, Inc., 549 Albany Street, Boston, MA 02118, USA.
Filer
Crist N
CN
D001386:Azides; D001713:Biphenyl Compounds / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000302:isolation & purification; D013373:Substance P / Q000037:antagonists & inhibitors*; D014316:Tritium / Q000737:chemistry*
D001386:Azides; D001713:Biphenyl Compounds; D019275:Radiopharmaceuticals; D014316:Tritium; D013373:Substance P; C066892:CP 96345