Trans-sodium crocetinate increases oxygen delivery to brain parenchyma in rats on oxygen supplementation.
Trans-sodium crocetinate (TSC) is a vitamin A-analog that increases diffusivity of oxygen in aqueous solutions, including plasma. The current study is the initial investigation of the effects of TSC on oxygen delivery to brain. Adult male rats were intubated and ventilated with 21%, 60%, or 100% oxygen. A craniotomy was performed and a Licox rat brain tissue PO(2) probe inserted into parietal cortex. Rats were then administered intravenous infusions of either TSC or saline and brain tissue PO(2) values were recorded. TSC significantly increased brain tissue oxygen delivery. This effect was minimal in rats ventilated with normal air and substantial in rats on oxygen supplementation. Arterial blood gas parameters did not differ within groups. These results provide clear indication to study the utility of TSC in ameliorating hypoxic/ischemic insults in neurological disorders.
Okonkwo
David O
DO
Department of Neuroscience, University of Virginia, P.O. Box 800212, Charlottesville, VA 22908-0212, USA. doo5a@hscmail.mcc.virginia.edu
Wagner
Jaime
J
Melon
David E
DE
Alden
Tord
T
Stone
James R
JR
Helm
Gregory A
GA
Jane
John A
JA
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002545:Brain Ischemia / Q000188:drug therapy / Q000378:metabolism; D002338:Carotenoids; D008297:Male; D010100:Oxygen / Q000008:administration & dosage* / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects* / Q000502:physiology; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000627:therapeutic use
C487773:trans-sodium crocetinate; D014801:Vitamin A; D002338:Carotenoids; D010100:Oxygen