title: Development of subcutaneous wound oxygen measurement in humans: contributions of Thomas K Hunt, MD.
abstract: When, in the early 1960s, Thomas K. Hunt, MD began investigating the role of oxygen in wound healing, he recognized that translation to humans would require the ability to measure oxygen tension in human wounds. This article will review his contributions to the development of subcutaneous tissue oxygen measurement and to the understanding of wound physiology and oxygen delivery, particularly through use of oxygen measurement. Hunt's major contributions to the field include the observations that all wounds show some degree of hypoxia, while many are severely hypoxic; the degree of hypoxia in wounds is sufficient to impair wound healing, and particularly bacterial killing by neutrophils, collagen deposition, angiogenesis, and epithelization; the sympathetic nervous system plays a central role in decreasing wound oxygen supply; and wound oxygen delivery and wound healing capacity can be increased by controlling the sympathetic nervous system. All these observations required tissue oxygen measurement, and, in particular, translation of basic scientific observations to clinical research required a method of measuring wound oxygen tension in humans.
authors: Department of Anesthesia and Perioperative Care, University of California, San Francisco, California 94143-0648, USA. hhopf@itsa.ucsf.edu
authors: Harriet W
authors: HW
authors: Hopf
mesh_terms: D015687:Cell Hypoxia / Q000502:physiology; D049673:History, 20th Century; D008365:Manometry; D010100:Oxygen / Q000378:metabolism / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D010100:Oxygen