Heparan sulfate proteoglycan 2 polymorphism in Alzheimer's disease and correlation with neuropathology.
A genetic association of an intronic single nucleotide polymorphism site of heparan sulfate proteoglycan 2 (HSPG2) with Alzheimer's disease (AD) was investigated among Finnish AD patients (n=213) and controls (n=269). No association of the HSPG2 polymorphism alone was observed with AD. However, an association of HSPG2 A allele with AD was detected in apolipoprotein (APOE) epsilon4 allele carriers. The odds ratio for AD was doubled in subjects carrying both epsilon4 and HSPG2 A alleles (OR=6.6) when compared to subjects with epsilon4 allele alone (OR=3.1). The impact of HSPG2 polymorphism on beta amyloid and tau pathology was studied using immunohistochemistry. Paired helical filament labeling was significantly more pronounced in AD patients carrying both epsilon4 and HSPG A alleles when compared to epsilon4 carriers lacking the HSPG2 A allele. In conclusion, HSPG2 A allele may possess an additive risk effect among the APOE epsilon4 carriers in AD.
Iivonen
Susan
S
Department of Neuroscience and Neurology, University Hospital and University of Kuopio, P.O. Box 1627, 70211, Kuopio, Finland. susan.iivonen@uku.fi
Helisalmi
Seppo
S
Mannermaa
Arto
A
Alafuzoff
Irina
I
Lehtovirta
Maarit
M
Soininen
Hilkka
H
Hiltunen
Mikko
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D016001:Confidence Intervals; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D019812:Heparan Sulfate Proteoglycans / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics*; D018709:Statistics, Nonparametric
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D019812:Heparan Sulfate Proteoglycans