title: [GPIIB/IIIA blockade after high-risk angioplasty: new perspectives].
abstract: The treatment of acute coronary syndromes knows today revolution, with the clinical use of platelet glycoprotein IIb/IIIa inhibitors. The benefit of these agents as adjunctive treatment for percutaneous coronary intervention has been substantial and consistently proved among trials; however patients undergoing revascularization after drug discontinuation demonstrated a moderate event reduction. In this analysis, including the entire large-scale trial experience of intravenous glycoprotein IIb/IIIa inhibitors, we try to evaluate this therapeutic class in the high risk coronary intervention, in patients with acute coronary syndromes primarily medically managed, and in combination therapy with thrombolytics in the acute myocardial infarction. The purpose was to demonstrate the reduction of cardiac events after administration of this drug in the different indications and to precise their different adverse effects.
authors: Service de Cardiologie, Hôpital Militaire Principal d'Instruction de Tunis.
authors: Zahreddine
authors: Z
authors: Smiri
authors: Dhaker
authors: D
authors: Lahidheb
authors: Néjib
authors: N
authors: Hajlaoui
authors: Nadia
authors: N
authors: Barakett
authors: Néjib
authors: N
authors: Rahal
authors: Foued
authors: F
authors: Azzouzi
authors: Wafa
authors: W
authors: Fehri
authors: Hédi
authors: H
authors: Mhenni
authors: Habib
authors: H
authors: Haouala
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D003327:Coronary Disease / Q000628:therapy; D006801:Humans; D009203:Myocardial Infarction / Q000628:therapy; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*
chemical_list: D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex