Reactivity of renal transplant sera against a 17 kD mononuclear cell antigen.
In recent years, studies have shown that non-HLA antigens can be involved in renal graft rejection. The so called minor antigens have been found to be expressed on a variety of cells, including endothelial cells. With the aim of understanding better the role of minor antigens in graft rejection, we undertook a Western blot screening of sera from patients waiting for or having received grafts from living-related or cadaveric donors. In this study we described the reactivity of these sera against a 17 kD antigen with expression in many different cell types.
Neumann
J
J
Laboratory of Transplantation Immunology Heart Institute and Renal Transplant Unit, Division of Urology, Faculty of Medicine, University of Sao Paulo, Brazil.
Spadafora-Ferreira
M
M
Goldberg
A C
AC
Tuder
R
R
Macaubas
C
C
Sabbaga
E
E
Kalil
J
J
D001402:B-Lymphocytes / Q000276:immunology; D015153:Blotting, Western; D002460:Cell Line; D016027:Heart Transplantation / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007519:Isoantigens / Q000276:immunology*; D016030:Kidney Transplantation / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008970:Molecular Weight; D012016:Reference Values; D013601:T-Lymphocytes / Q000276:immunology
D007074:Immunoglobulin G; D007519:Isoantigens