title: Clinical and [99mTc]TRODAT-1/[123I]IBZM SPECT imaging findings in dopa-responsive dystonia.
abstract: We report the clinical and dopamine transporter/D2 receptor single-photon emission computed tomographic (SPECT) imaging findings in a 39-year-old woman with a 24-year history of dopa-responsive dystonia (DRD). The SPECT imaging of the dopamine transporter with [(99m)Tc]TRODAT-1 is helpful in differentiating DRD from early-onset idiopathic parkinsonism. In the later clinical course, the [(123)I]IBZM SPECT is also helpful in differentiating these two conditions. The patient showed a dramatic and sustained response to levodopa, and needed a smaller dose of levodopa for symptom control in the later course.
authors: Department of Neurology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. wjhwang@mail.ncku.edu
authors: Wen-Juh
authors: WJ
authors: Hwang
authors: Wei-Jen
authors: WJ
authors: Yao
authors: Shiaw-Pyng
authors: SP
authors: Wey
authors: Gann
authors: G
authors: Ting
mesh_terms: D000328:Adult; D001549:Benzamides; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D003287:Contrast Media; D003937:Diagnosis, Differential; D015259:Dopamine Agents / Q000627:therapeutic use; D050483:Dopamine Plasma Membrane Transport Proteins; D004421:Dystonia / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins; D015609:Organotechnetium Compounds; D020734:Parkinsonian Disorders / Q000175:diagnosis; D011759:Pyrrolidines; D019275:Radiopharmaceuticals; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014326:Tropanes
chemical_list: D001549:Benzamides; D003287:Contrast Media; D015259:Dopamine Agents; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D015609:Organotechnetium Compounds; D011759:Pyrrolidines; D019275:Radiopharmaceuticals; D017448:Receptors, Dopamine D2; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1; D007980:Levodopa; C055743:3-iodo-2-hydroxy-6-methoxy-N-((1-ethyl-2-pyrrolidinyl)methyl)benzamide