Leptin levels increase during flutamide therapy in women with polycystic ovary syndrome.
OBJECTIVE
To evaluate the serum leptin levels and the effects of flutamide treatment on the leptin levels in women with polycystic ovary syndrome (PCOS).


METHODS
20 women with PCOS and 20 controls were enrolled in the study. Leptin levels and leptin response to an oral glucose tolerance test were assessed in both groups before and after a 4-week flutamide therapy period.


RESULTS
The leptin levels were similar in both groups at baseline. In the PCOS group, leptin levels and area under curve for leptin levels increased significantly after flutamide treatment.


CONCLUSIONS
Women with PCOS had similar leptin levels to those of controls with similar age and body mass index. Flutamide treatment led to increased leptin levels and leptin responses to oral glucose tolerance tests in PCOS patients. Further studies are needed to gain insights into the clinical consequences of these effects of flutamide.
Sahin
Ibrahim
I
Department of Endocrinology and Metabolic Diseases, Inönü University Faculty of Medicine, Malatya, Turkey. isahin@inonu.edu.tr
Serter
Rustu
R
Karakurt
Feridun
F
Demirbas
Berrin
B
Guler
Serdar
S
Culha
Cavit
C
Taskapan
Cagatay
C
Aral
Yalcin
Y
D000293:Adolescent; D000328:Adult; D000726:Androgen Antagonists / Q000627:therapeutic use*; D000886:Anthropometry; D019540:Area Under Curve; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D005485:Flutamide / Q000627:therapeutic use*; D005951:Glucose Tolerance Test; D006728:Hormones / Q000097:blood; D006801:Humans; D020738:Leptin / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000188:drug therapy*
D000726:Androgen Antagonists; D001786:Blood Glucose; D006728:Hormones; D020738:Leptin; D005485:Flutamide