Complex of vitamins and antioxidants protects low-density lipoproteins in blood plasma from free radical oxidation and activates antioxidants enzymes in erythrocytes from patients with coronary heart disease.
We studied the effect of a complex containing antioxidant vitamins C and E, provitamin A, and antioxidant element selenium on the contents of primary (lipid peroxides) and secondary products (malonic dialdehyde) of free radical lipid oxidation in low-density lipoproteins isolated from the plasma of patients with coronary heart disease and hypercholesterolemia by means of preparative ultracentrifugation. Activity of key antioxidant enzymes in the blood was measured during treatment with the antioxidant preparation. Combination treatment with antioxidant vitamins and antioxidant element selenium sharply decreased the contents of primary and secondary free radical oxidation products in circulating low-density lipoproteins and increased activity of antioxidant enzymes in erythrocytes. Activities of superoxide dismutase and selenium-containing glutathione peroxidase increased 1 and 2 months after the start of therapy, respectively.
Konovalova
G G
GG
Laboratory of Biochemistry of Free Radical Processes, A. L. Myasnikov Institute of Cardiology, Russian Research-and-Production Center for Cardiology, Russian Ministry of Health, Moscow. konovalova@vipmail.ru
Lankin
V Z
VZ
Tikhaze
A K
AK
Nezhdanova
I B
IB
Lisina
M O
MO
Kukharchuk
V V
VV
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D002374:Catalase / Q000097:blood; D003327:Coronary Disease / Q000188:drug therapy / Q000378:metabolism*; D004912:Erythrocytes / Q000201:enzymology*; D005609:Free Radicals / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D010084:Oxidation-Reduction; D012643:Selenium / Q000008:administration & dosage / Q000378:metabolism; D013482:Superoxide Dismutase / Q000097:blood; D014815:Vitamins / Q000378:metabolism* / Q000494:pharmacology
D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D008077:Lipoproteins, LDL; D014815:Vitamins; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium