Thiourea inhibitors of herpes viruses. Part 1: bis-(aryl)thiourea inhibitors of CMV.
Bis-(aryl)thioureas were found to be potent and selective inhibitors of cytomegalovirus (CMV) in cultured HFF cells. Of these, the thiazole analogue 38 was investigated as a potential development candidate.
Bloom
Jonathan D
JD
Wyeth Research, Pearl River, NY 10965, USA. bloomj@wyeth.com
DiGrandi
Martin J
MJ
Dushin
Russell G
RG
Curran
Kevin J
KJ
Ross
Adma A
AA
Norton
Emily B
EB
Terefenko
Eugene
E
Jones
Thomas R
TR
Feld
Boris
B
Lang
Stanley A
SA
D000215:Acylation; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects*; D006564:Herpesviridae / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000998:Antiviral Agents; D001555:Benzene Derivatives; D013890:Thiourea