SUMO: ligases, isopeptidases and nuclear pores.
Small ubiquitin-related modifier (SUMO) proteins are reversibly coupled to numerous intracellular targets and modulate their interactions, localization, activity or stability. Recent advances in the SUMO field have uncovered the first SUMO E3 ligases and point to a complex family of isopeptidases. SUMO has been linked to many different pathways, including nucleocytoplasmic transport. Modifying enzymes and an isopeptidase have been detected at nuclear pore complexes. In addition, studies in yeast suggest a requirement of SUMO conjugation for nuclear protein import, and specific SUMO targets depend on modification for nuclear import or export.
Melchior
Frauke
F
Max-Planck Institute for Biochemistry, Am Klopferspitz 18a, 82152 Martinsried, Germany. melchior@biochem.mpg.de
Schergaut
Marion
M
Pichler
Andrea
A
D021581:Active Transport, Cell Nucleus; D000818:Animals; D019759:Carbon-Nitrogen Lyases / Q000378:metabolism*; D006801:Humans; D022022:Nuclear Pore / Q000502:physiology*; D028861:Nuclear Pore Complex Proteins; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
D028861:Nuclear Pore Complex Proteins; D025841:Small Ubiquitin-Related Modifier Proteins; D044767:Ubiquitin-Protein Ligases; D019759:Carbon-Nitrogen Lyases; C034300:isopeptidase