title: Control of effector CD8+ T cell function by the transcription factor Eomesodermin.
abstract: Activated CD8+ T cells play a critical role in host defense against viruses, intracellular microbes, and tumors. It is not clear if a key regulatory transcription factor unites the effector functions of CD8+ T cells. We now show that Eomesodermin (Eomes), a paralogue of T-bet, is induced in effector CD8+ T cells in vitro and in vivo. Ectopic expression of Eomes was sufficient to invoke attributes of effector CD8+ T cells, including interferon-gamma (IFN-gamma), perforin, and granzyme B. Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8+ T cells. We suggest that Eomesodermin is likely to complement the actions of T-bet and act as a key regulatory gene in the development of cell-mediated immunity.
authors: Abramson Family Cancer Research Institute, and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors: Erika L
authors: EL
authors: Pearce
authors: Alan C
authors: AC
authors: Mullen
authors: Gislâine A
authors: GA
authors: Martins
authors: Connie M
authors: CM
authors: Krawczyk
authors: Anne S
authors: AS
authors: Hutchins
authors: Valerie P
authors: VP
authors: Zediak
authors: Monica
authors: M
authors: Banica
authors: Catherine B
authors: CB
authors: DiCioccio
authors: Darrick A
authors: DA
authors: Gross
authors: Chai-An
authors: CA
authors: Mao
authors: Hao
authors: H
authors: Shen
authors: Nezih
authors: N
authors: Cereb
authors: Soo Y
authors: SY
authors: Yang
authors: Tullia
authors: T
authors: Lindsten
authors: Janet
authors: J
authors: Rossant
authors: Christopher A
authors: CA
authors: Hunter
authors: Steven L
authors: SL
authors: Reiner
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001117:Arenaviridae Infections / Q000276:immunology; D001483:Base Sequence; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000502:physiology; D002454:Cell Differentiation; D003602:Cytotoxicity, Immunologic; D005786:Gene Expression Regulation; D053804:Granzymes; D007371:Interferon-gamma / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012697:Serine Endopeptidases / Q000096:biosynthesis / Q000235:genetics; D020825:T-Box Domain Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018418:Th2 Cells / Q000276:immunology / Q000502:physiology; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D000098815:T-bet Transcription Factor
chemical_list: C491198:Eomes protein, mouse; D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D012333:RNA, Messenger; D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D014157:Transcription Factors; D054353:Perforin; D007371:Interferon-gamma; D053804:Granzymes; C509214:Gzmb protein, mouse; D012697:Serine Endopeptidases