High body mass index, asthma and allergy in Swedish schoolchildren participating in the International Study of Asthma and Allergies in Childhood: Phase II.
OBJECTIVE
To assess the relationship between high body mass index (BMI) and asthma and atopic manifestations in 12-y-old children.


METHODS
The relationship between high BMI and asthma symptoms was studied in 457 sixth-grade children, with (n = 161) and without (n = 296) current wheeze. High BMI was defined as > or = 75th percentile of gender-specific BMI reference values for Swedish children at 12 y of age; overweight as a subgroup of high BMI was defined as > or = 95th percentile. Children with a BMI < 75th percentile served as controls. Questionnaires were used to assess asthmatic and allergic symptoms, and bronchial hyperresponsiveness was assessed by hypertonic saline provocation tests.


RESULTS
Current wheeze was associated with high BMI after adjustment for confounding factors (adjusted OR 1.7, 95% CI 1.0-2.5) and overweight had an even more pronounced effect (adjusted OR 1.9, 95% CI 1.0-3.6). In addition, asthma severity was associated with high BMI, as evaluated by the number of wheezing episodes during the previous 12 mo among the wheezing children (adjusted OR 2.0, 95% CI 1.0-4.0). There was also an association between high BMI and the presence of eczema in wheezing children (adjusted OR 2.2, 95% CI 1.0-4.6). However, high BMI was not significantly associated with hay fever, positive skin prick tests or bronchial hyperresponsiveness.


CONCLUSIONS
The study confirms and extends a previously observed relationship between BMI and the presence of wheezing and asthma.
Mai
X M
XM
Department of Molecular and Clinical Medicine, Division of Paediatrics, Faculty of Health Sciences, Linköping University, Sweden. xiama@imk.liu.se
Nilsson
L
L
Axelson
O
O
Bråbäck
L
L
Sandin
A
A
Kjellman
N I M
NI
Björkstén
B
B
D000293:Adolescent; D001249:Asthma / Q000453:epidemiology* / Q000503:physiopathology; D015992:Body Mass Index; D001835:Body Weight; D016535:Bronchial Hyperreactivity / Q000453:epidemiology; D002648:Child; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D016015:Logistic Models; D008297:Male; D012016:Reference Values; D012135:Respiratory Sounds; D013548:Sweden / Q000453:epidemiology