COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells.
We have detected an expressed mRNA encoding a splice variant of COX-1 in the mouse central nervous system. This isoform, referred to as COX-3, is identical in sequence to COX-1 except for the in-frame retention of intron 1. Like its counterpart COX-1, COX-3 does not generally appear to be induced by acute inflammatory stimulation.
Shaftel
Solomon S
SS
Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Olschowka
John A
JA
Hurley
Sean D
SD
Moore
Amy H
AH
O'Banion
M Kerry
MK
D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D001253:Astrocytes / Q000201:enzymology; D001483:Base Sequence / Q000235:genetics; D001921:Brain / Q000166:cytology / Q000201:enzymology*; D002478:Cells, Cultured; D051545:Cyclooxygenase 1; D018076:DNA, Complementary / Q000032:analysis / Q000235:genetics; D004660:Encephalitis / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics; D007438:Introns / Q000235:genetics; D007527:Isoenzymes / Q000235:genetics; D008565:Membrane Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D017628:Microglia / Q000201:enzymology; D008969:Molecular Sequence Data; D009457:Neuroglia / Q000166:cytology / Q000201:enzymology*; D009474:Neurons / Q000166:cytology / Q000201:enzymology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics*; D020033:Protein Isoforms / Q000235:genetics
D018076:DNA, Complementary; D007527:Isoenzymes; D008565:Membrane Proteins; D020033:Protein Isoforms; D051545:Cyclooxygenase 1; D011451:Prostaglandin-Endoperoxide Synthases; C496512:Ptgs1 protein, mouse; C466421:cyclooxygenase-3