Efforts to determine the role of oxidant stress in dialysis outcomes.
The role of elevated markers of oxidant stress needs to be established in longitudinal studies. Oxidant stress markers such as malonaldehyde (MDA), isoprostanes, and breath hydrocarbons warrant rigorous application to outcomes, if they are to be used as clinical parameters. For example, investigations of C-reactive protein (CRP), parathyroid hormone (PTH), and several other clinical indicators have shown that these markers can be used to predict outcomes such as morbidity and mortality. Long-term followup is needed for intervention studies with antioxidants, since effects with short-term studies may be focused on critically-ill individuals where intervention would not be expected to be effective. Oxidant stress studies in this population especially need a long-term approach to test the hypothesis that antioxidant intervention is beneficial.
Handelman
Garry J
GJ
Health and Clinical Science, University of Massachusetts, Lowell, Massachusetts 01854, USA. Garry_Handelman@uml.edu
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D006801:Humans; D018384:Oxidative Stress; D011237:Predictive Value of Tests; D017382:Reactive Oxygen Species / Q000032:analysis*; D006435:Renal Dialysis / Q000009:adverse effects*
D000975:Antioxidants; D017382:Reactive Oxygen Species