title: HAART induces the expression of HLA-G on peripheral monocytes in HIV-1 infected individuals.
abstract: The aim of this work is to analyze if the highly active antiretroviral therapy (HAART) has any effect in the number of peripheral monocytes expressing the tolerogenic molecule human leukocyte antigen G (HLA-G) in HIV-1 infected individuals. In this sense, expression of HLA-G was measured by flow cytometry on peripheral monocytes from HIV-1 antiretroviral-receiving and antiretroviral naïve patients and in HIV-1 patients at different times after the antiretroviral treatments were removed. It was found an increment of monocytes expressing HLA-G in HIV-1 infected individuals receiving HAART, whereas monocytes from untreated HIV-1 patients did not change. When the HLA-G was measured on monocytes after antiretroviral treatment was removed, the number of peripheral monocytes expressing HLA-G was progressively decreasing. These data suggest that antiretroviral therapy is able to induce the expression of the tolerogenic molecule HLA-G on peripheral monocytes from HIV-1 seropositive individuals.
authors: Service of Immunology, Reina Sofía University Hospital, University of Cordoba, Spain.
authors: Almudena
authors: A
authors: Cabello
authors: Antonio
authors: A
authors: Rivero
authors: Mariá José
authors: MJ
authors: Garcia
authors: José Manuel
authors: JM
authors: Lozano
authors: Julian
authors: J
authors: Torre-Cisneros
authors: Rafael
authors: R
authors: González
authors: Gema
authors: G
authors: Dueñas
authors: Maria Dolores
authors: MD
authors: Galiani
authors: Angela
authors: A
authors: Camacho
authors: Manuel
authors: M
authors: Santamaria
authors: Rafael
authors: R
authors: Solana
authors: Carmen
authors: C
authors: Montero
authors: José Mariá
authors: JM
authors: Kindelán
authors: José
authors: J
authors: Peña
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D005434:Flow Cytometry; D015658:HIV Infections / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D015497:HIV-1; D006680:HLA Antigens / Q000096:biosynthesis / Q000097:blood* / Q000235:genetics; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis / Q000097:blood* / Q000235:genetics; D006801:Humans; D009000:Monocytes / Q000276:immunology*; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use
chemical_list: D017320:HIV Protease Inhibitors; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D018894:Reverse Transcriptase Inhibitors