title: Liquid chromatographic determination of pyrantel tartrate in medicated formulations.
abstract: The validation of a novel liquid chromatographic (LC) method for the determination of pyrantel tartrate in feed is presented. The method provides a significant improvement over the efficiency and precision of AOAC Official Method 978.30. The method was shown to be accurate, precise, linear, and robust for medicated articles. Unlike the official method, the LC method was shown to be a superior stability-indicating method. After the method was validated by using laboratory blends, the effectiveness of the method was demonstrated with marketed product as well.
authors: Pfizer Global Manufacturing, Quality Operations, One Pfizer Way, Lee's Summit, MO 64081, USA.
authors: Joyce A
authors: JA
authors: Konrardy
authors: Mary A
authors: MA
authors: Burner
authors: Tommy W
authors: TW
authors: Garner
authors: Mark A
authors: MA
authors: Litchman
authors: Gregory K
authors: GK
authors: Webster
mesh_terms: D000821:Animal Feed / Q000032:analysis*; D000871:Anthelmintics / Q000032:analysis*; D002853:Chromatography, Liquid / Q000191:economics / Q000379:methods*; D011717:Pyrantel Tartrate / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D000871:Anthelmintics; D011717:Pyrantel Tartrate