title: [Association of angiotensinogen gene polymorphism with hypertension in type 2 diabetic patients].
abstract: OBJECTIVE
  To investigate the relationship between angiotensinogen (AGT) gene polymorphism and hypertension in type 2 diabetic patients.
  
  
  METHODS
  A total of 240 patients with type 2 diabetes mellitus were divided into normotensive and hypertensive groups according to their blood pressure measurement, and their fasting plasma glucose, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein and very-low-density lipoprotein were measured. The AGT genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  The distributions of AGT genotypes in normotensive and hypertensive groups were similar, and the frequency of M allele in female hypertensive patients was significantly higher than that in female normotensive patients.
  
  
  CONCLUSIONS
  The M allele of AGT gene is probably related to hypertension in female type 2 diabetic patients.
authors: Department of Endocrinology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
authors: Yao-ming
authors: YM
authors: Xue
authors: Mei-ping
authors: MP
authors: Guan
authors: Shi-qun
authors: SQ
authors: Liu
authors: Qian
authors: Q
authors: Zhang
authors: Lin
authors: L
authors: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D000808:Angiotensinogen / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D000808:Angiotensinogen