Mitochondrial regulation of intracellular Ca2+ signaling: more than just simple Ca2+ buffers.
Mitochondrial Ca(2+) uptake shapes the profile of intracellular Ca(2+) signals, both spatially and temporally. In addition, such uptake controls the gating of Ca(2+) release and store-operated Ca(2+) entry channels, partitions cells into subcellular Ca(2+) hotspots, and can result in the release of diffusible signals into the cytosol that subsequently regulate protein function.
Parekh
Anant B
AB
Department of Physiology, University of Oxford, Oxford OX1 3PT, UK.
D000818:Animals; D002021:Buffers; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D007425:Intracellular Membranes / Q000378:metabolism*; D008928:Mitochondria / Q000502:physiology*
D002021:Buffers; D002118:Calcium