HIV-1 superinfection.
During the past year, a number of reports have described HIV-1 superinfection in human subjects, defined as the reinfection of an individual with a second heterologous strain of HIV-1. These reports have challenged the assumption that HIV-1-specific immune responses generated during primary infection are protective against subsequent infection and have raised concern, not only with respect to HIV-1-positive individuals engaging in unsafe sex but also from the standpoint of developing effective vaccines. Herein we review the published reports of HIV-1 superinfection and highlight studies providing additional insight into the potential for HIV-1 superinfections to affect the global epidemic.
Allen
Todd M
TM
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.
Altfeld
Marcus
M
D000818:Animals; D004195:Disease Models, Animal; D015195:Drug Design; D015658:HIV Infections; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D011995:Recombination, Genetic; D015163:Superinfection; D014765:Viral Vaccines
D014765:Viral Vaccines