title: Progression of a myxoid pleomorphic fibroma to myxofibrosarcoma.
abstract: A 75-year-old man presented with a protuberant stable lesion of many years on his left second toe. Histology on an incisional biopsy showed myxoid pleomorphic fibroma. Over the subsequent 21 months, the lesion enlarged and became exophytic and irregular. Repeat biopsy showed features consistent with a grade III myxofibrosarcoma. Treatment involved amputation of his toe. Six months later he remains well, with no evidence of local recurrence or systemic spread.
authors: Department of Dermatology, Royal Brisbane Hospital, Herston, Queensland, Australia. nigelandamanda@bigpond.com
authors: Amanda
authors: A
authors: Dore
authors: Ivan
authors: I
authors: Robertson
authors: Richard
authors: R
authors: Williamson
authors: David
authors: D
authors: Weedon
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005500:Follow-Up Studies; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009236:Myxosarcoma / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome