Inflated and contradictory category naming deficits in Alzheimer's disease?
Although some studies have documented category-specific deficits in patients with Alzheimer's disease, others have not. One possible reason is that where control groups have been used in previous studies, they have performed at ceiling; and this may spuriously affect the incidence and type of deficit reported (especially with common statistical techniques such as z-scores). We examined this issue in 18 Alzheimer's patients and 26 elderly controls, who named two picture sets: a simple set that typically produces ceiling effects (Set 1) and one that produces a normal distribution in controls (Set 2). Sets 1 and 2 produced inconsistent and even contradictory deficits in the same patients. The results also show that ceiling effects may inflate the number of living thing deficits and hence, distort the reported ratio of living to nonliving cases.
Laws
Keith R
KR
Brain and Cognition Research Group, Division of Psychology, Nottingham Trent University, UK. keith.laws@ntu.ac.uk
Leeson
Verity C
VC
Gale
Tim M
TM
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications*; D000849:Anomia / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D012720:Severity of Illness Index