title: Prevention and therapy of fungal infection in severe acute pancreatitis: A prospective clinical study.
abstract: OBJECTIVE
  To investigate the prevention and therapy of fungal infection in patients with severe acute pancreatitis (SAP).
  
  
  METHODS
  Seventy patients with SAP admitted from Jan. 1998 to Dec. 2002 were randomly divided into garlicin prevention group, fluconazole (low dosage) prevention group and control group. The incidence of fungal infection, the fungal clearance and mortality after treatment were compared.
  
  
  RESULTS
  The incidence of fungal infection in garlicin group and fluconazole group was lower than that in control group (16% vs 30%, P<0.05 and 9% vs 30%, P<0.01, respectively). Amphotericin B or therapy-dose fluconazole had effects on patients with fungal infection in garlicin group and control group, but had no effects on patients with fungal infection in fluconzole group.
  
  
  CONCLUSIONS
  Prophylactic dosage of antifungal agents (garlicin or low dosage fluconazole) can reduce the incidence of fungal infection in patients with SAP. But once fungal infection occurs, amphotericin B should be used as early as possible if fluconazole is not effective.
authors: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan Province, China. heym@medmail.com.cn
authors: Yue-Ming
authors: YM
authors: He
authors: Xin-Sheng
authors: XS
authors: Lv
authors: Zhong-Li
authors: ZL
authors: Ai
authors: Zhi-Su
authors: ZS
authors: Liu
authors: Qun
authors: Q
authors: Qian
authors: Quan
authors: Q
authors: Sun
authors: Ji-Wei
authors: JW
authors: Chen
authors: Dao-Xiong
authors: DX
authors: Lei
authors: Cong-Qing
authors: CQ
authors: Jiang
authors: Yu-Fong
authors: YF
authors: Yuan
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000498:Allyl Compounds / Q000008:administration & dosage; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage*; D004220:Disulfides / Q000008:administration & dosage; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy* / Q000401:mortality / Q000517:prevention & control*; D010195:Pancreatitis / Q000382:microbiology* / Q000401:mortality; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000498:Allyl Compounds; D000935:Antifungal Agents; D004220:Disulfides; C028009:diallyl disulfide; D000666:Amphotericin B; D015725:Fluconazole