title: Hypotony and choroidal effusion induced by topical timolol and dorzolamide in patients with previous glaucoma drainage device implantation.
abstract: Three patients with glaucoma drainage devices and one patient who had trabeculectomy with mitomycin C were treated with a combination of topical timolol 0.5% and dorzolamide hydrochloride in the late postoperative period to decrease the intraocular pressure to the target level. All four patients developed ciliochoroidal effusions with hypotony that resolved with the discontinuation of the topical medication. Aqueous suppressants can induce ciliochoroidal effusions and hypotony in the late postoperative phase in some patients with glaucoma drainage devices. Discontinuation of the medication usually results in the resolution of the choroidal effusions.
authors: Department of Ophthalmology, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA.
authors: Claiborne
authors: C
authors: Callahan
authors: Ramesh S
authors: RS
authors: Ayyala
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects*; D015862:Choroid Diseases / Q000139:chemically induced*; D004359:Drug Therapy, Combination; D005260:Female; D005901:Glaucoma / Q000188:drug therapy / Q000601:surgery*; D020327:Glaucoma Drainage Implants; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use; D015814:Ocular Hypotension / Q000139:chemically induced*; D009883:Ophthalmic Solutions; D019919:Prosthesis Implantation; D013449:Sulfonamides / Q000009:adverse effects; D013876:Thiophenes / Q000009:adverse effects; D013999:Timolol / Q000009:adverse effects; D014130:Trabeculectomy
chemical_list: D000959:Antihypertensive Agents; D009883:Ophthalmic Solutions; D013449:Sulfonamides; D013876:Thiophenes; D016685:Mitomycin; D013999:Timolol; C062765:dorzolamide