Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1.
Adaptor proteins act as conduits to channel upstream signals into downstream effector branches. Two B cell-associated adaptors, Bam32 and Carma1, regulate the ERK, JNK, and NF-kappaB branches of the BCR signaling pathway. Recent studies of Bam32-/- and Carma1-/- mice suggest that each adaptor controls a distinct conduit regulating either only proliferation (Bam32) or both the proliferation and survival of B cells (Carma1).
Niiro
Hiroaki
H
Department of Microbiology, University of Washington, Seattle, WA 98195, USA.
Clark
Edward A
EA
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D051528:Guanylate Kinases; D008074:Lipoproteins; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009703:Nucleoside-Phosphate Kinase / Q000378:metabolism*; D011947:Receptors, Antigen, B-Cell / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C403524:Dapp1 protein, mouse; D008074:Lipoproteins; D008565:Membrane Proteins; D011947:Receptors, Antigen, B-Cell; D009703:Nucleoside-Phosphate Kinase; D051528:Guanylate Kinases