title: Large B-cell lymphoma of the leg in a patient with multiple malignant tumours.
abstract: A patient who had primary gastric B-cell non-Hodgkin's lymphoma, invasive ductal breast cancer and a basocellular carcinoma of the forehead in her medical history was studied. Three years after polychemotherapy and irradiation of the breast cancer, a rapidly enlarging, ulcerated violaceous tumour developed on the patient's left leg. The tumour was identified by the histopathological, immunohistochemical and immunoglobulin gene rearrangement analyses as a cutaneous large B-cell lymphoma. No signs of extracutaneous involvement were detectable. Despite surgical excision, interferon-alpha2b treatment and chlorambucil + prednisone chemotherapy, a relapse occurred in the previously affected site, whereafter the patient received radiotherapy. She was lost to follow-up, and died approximately 14 months after the surgical intervention without autopsy. We discuss the clinical and histologic features and outcome of the large B-cell lymphoma of the leg, its coincidence with other diseases, and the uncommon occurrence of primary multiple malignant tumours.
authors: Department of Dermatology, Semmelweis Hospital, Miskolc, Hungary. dr.eros@freemail.hu
authors: Nora
authors: N
authors: Eros
authors: Zsuzsanna
authors: Z
authors: Karolyi
authors: Anikó
authors: A
authors: Kovács
authors: András
authors: A
authors: Matolcsy
authors: Tibor
authors: T
authors: Barna
authors: Gábor
authors: G
authors: Kelényi
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000150:complications* / Q000628:therapy; D002280:Basal Cell Carcinoma / Q000150:complications* / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000150:complications* / Q000628:therapy; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D005546:Forehead; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000628:therapy; D012878:Skin Neoplasms / Q000150:complications* / Q000628:therapy; D013274:Stomach Neoplasms / Q000150:complications* / Q000628:therapy