title: Long-term outcome after implantation of bare metal stents for the treatment of coronary artery disease: rationale for the clinical use of antiproliferative stent coatings.
abstract: BACKGROUND
  The widespread use of drug-eluting stents in patients with coronary artery disease (CAD) is hampered by unequal regulations for reimbursement. Identification of patients with maximal benefit from this technology may be achieved by assessing long-term clinical outcome after implantation of uncoated bare metal stents.
  
  
  METHODS
  A consecutive series of 1,000 patients with CAD treated with bare metal coronary stents of various designs from January 1995 to December 1995 was retrospectively followed over 4 years. The primary end points of the study were major adverse cardiac events.
  
  
  RESULTS
  The mean age of patients was 62 +/- 10.3 years, 77.5% were male, and 18% were diabetic. Clinical follow-up was obtained in 821 patients (82.1%) after 4.6 +/- 1.1 years. During this period of time, 31.8% were admitted for repeat PCI, 15.1% underwent CABG operation, 3.5% had myocardial infarctions, and 3.7% died. At 4 years, 46.3% of diabetic patients survived without event versus 57.6% of nondiabetic patients (P < 0.05). Patients with CAD I survived without event in 65.3% versus 54.0% of patients with CAD II and 48.5% of patients with CAD III (P < 0.02).
  
  
  CONCLUSIONS
  Implantation of uncoated stents provides the worst long-term clinical outcome in patients with diabetes and those with multivessel CAD. Both groups of patients appear to be primary candidates for the use of drug-eluting stents.
authors: Red Cross Hospital Cardiology Center, Frankfurt/Main, Germany. kardio.centrum@t-online.de
authors: Jürgen
authors: J
authors: Haase
authors: Tobias
authors: T
authors: Jung
authors: Hans
authors: H
authors: Störger
authors: Manfred
authors: M
authors: Hofmann
authors: Harald
authors: H
authors: Reinemer
authors: Claus-Eberhard
authors: CE
authors: Schwarz
authors: Josef
authors: J
authors: Schöpf
authors: Franz
authors: F
authors: Schwarz
mesh_terms: D020099:Coated Materials, Biocompatible; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000628:therapy*; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D008670:Metals; D008875:Middle Aged; D009204:Myocardial Revascularization / Q000534:rehabilitation / Q000706:statistics & numerical data*; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies; D015607:Stents / Q000009:adverse effects / Q000706:statistics & numerical data*; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D020099:Coated Materials, Biocompatible; D008670:Metals