title: Functional and structural alterations of the intraparietal sulcus in a developmental dyscalculia of genetic origin.
abstract: Cognitive theories of numerical representation suggest that understanding of numerical quantities is driven by a magnitude representation associated with the intraparietal sulcus and possibly under genetic control. The aim of this study was to investigate, using fMRI and structural imaging, the interaction between the abnormal development of numerical representation in an X-linked condition, Turner syndrome (TS), and the development of the intraparietal sulcus. fMRI during exact and approximate calculation in TS showed an abnormal modulation of intraparietal activations as a function of number size. Morphological analysis revealed an abnormal length, depth, and sulcal geometry of the right intraparietal sulcus, suggesting an important disorganization of this region in TS. Thus, a genetic form of developmental dyscalculia can be related to both functional and structural anomalies of the right intraparietal sulcus, suggesting a crucial role of this region in the development of arithmetic abilities.
authors: INSERM U 562, Cognitive Neuroimaging, Service Hospitalier Frédéric Joliot, CEA/DSV, IFR 49 Orsay, France. molko@wanadoo.fr
authors: Nicolas
authors: N
authors: Molko
authors: Arnaud
authors: A
authors: Cachia
authors: Denis
authors: D
authors: Rivière
authors: Jean François
authors: JF
authors: Mangin
authors: Marie
authors: M
authors: Bruandet
authors: Denis
authors: D
authors: Le Bihan
authors: Laurent
authors: L
authors: Cohen
authors: Stanislas
authors: S
authors: Dehaene
mesh_terms: D000328:Adult; D001931:Brain Mapping; D041321:Chromosomes, Human, X / Q000235:genetics; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D007859:Learning Disabilities / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology; D008279:Magnetic Resonance Imaging; D008297:Male; D008433:Mathematics; D009415:Nerve Net / Q000002:abnormalities / Q000473:pathology / Q000503:physiopathology; D009421:Nervous System Malformations / Q000473:pathology / Q000503:physiopathology* / Q000523:psychology; D009434:Neural Pathways / Q000002:abnormalities / Q000473:pathology / Q000503:physiopathology; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology*; D014424:Turner Syndrome / Q000150:complications* / Q000503:physiopathology / Q000523:psychology