title: Revaccination with the 23-valent pneumococcal polysaccharide vaccine in middle-aged and elderly persons previously treated for pneumonia.
abstract: Revaccination with the 23-valent pneumococcal polysaccharide vaccine (PPV) has remained controversial due to lack of immunological data and fear of side effects. We re-vaccinated 61 elderly patients (median age 75 years), who had a history of hospital treatment for pneumonia, with PPV on average 5.3 years after their primary vaccination. Revaccination resulted in significant increases of the geometric mean antibody concentration (GMC) and the geometric mean antibody fold increase (GMFI), although to lower levels than after primary vaccination. 36/61 (59%) of the patients responded with a GMFI of > or =2 to > or =2 of six serotypes. Local reactions to revaccination were common (63%), but mild, and there were no serious adverse events. We conclude that revaccination of elderly with PPV after 5-10 years is safe and induce a significant immune response in a majority of persons.
authors: Department of Medicine, Unit of Infectious Diseases, Karolinska Hospital, Karolinska Institutet, S-17176 Stockholm, Sweden. jan.torling@ks.se
authors: Jan
authors: J
authors: Törling
authors: Jonas
authors: J
authors: Hedlund
authors: Helle Bossen
authors: HB
authors: Konradsen
authors: Ake
authors: A
authors: Ortqvist
mesh_terms: D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis / Q000096:biosynthesis; D015331:Cohort Studies; D005260:Female; D006760:Hospitalization; D006801:Humans; D007273:Injections, Intramuscular; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D011018:Pneumonia, Pneumococcal / Q000276:immunology* / Q000628:therapy; D011134:Polysaccharides / Q000276:immunology; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D008070:Lipopolysaccharides; D022242:Pneumococcal Vaccines; D011134:Polysaccharides