[Study on the status of cell differentiation in nasal NK/T-cell lymphomas].
OBJECTIVE
To evaluate the status of cell differentiation in nasal NK/T cell lymphomas.


METHODS
The clinical data of 88 cases of NK/T cell lymphomas were collected. Antibodies to the following antigens were used in the immunohistochemical study: T cell differentiation antigens (CD3epsilon, CD5 and CD1a); NK cell associated antigens (CD56, CD57) and antibodies of CD34 and CD38.


RESULTS
(1) Clinicopathology: clinically, frequently involved sites were the nasal cavity and the pharynx. Ulceration and erosion of the mucosa were common signs. Pathologically, diffuse infiltration of the tumor cells was observed in 68 of 88 (70.45%) cases of nasal NK/T cell lymphomas. In 71 (80.68%) cases infiltrated cells were predominantly medium to large sized; (2) Differentiation status of tumor cells: the tumor cells expressed CD3epsilon in 78/88 (88.64%); CD5 in 56/88 (63.63%), CD56 in 25/88 (28.41%) and no positivity for CD1a, CD57, CD34 and CD38.


CONCLUSIONS
Status of tumor cell differentiation in nasal NK/T cell lymphoma may have passed the stage of progenitor cell differentiation but not yet to the stage of mature T or NK cells.
Jiang
Yu-mei
YM
Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.
Liu
Wei-ping
WP
Tang
Qiong-lan
QL
Li
Gan-di
GD
Guo
Jia
J
Liao
Dian-ying
DY
D000293:Adolescent; D000328:Adult; D000368:Aged; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000276:immunology / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000276:immunology / Q000473:pathology*