title: Synthesis and aqueous solution properties of novel sugar methacrylate-based homopolymers and block copolymers.
abstract: We report the facile preparation of a range of novel, well-defined cyclic sugar methacrylate-based polymers without recourse to protecting group chemistry. 2-Gluconamidoethyl methacrylate (GAMA) and 2-lactobionamidoethyl methacrylate (LAMA) were prepared directly by reacting 2-aminoethyl methacrylate with D-gluconolactone and lactobionolactone, respectively. Homopolymerization of GAMA and LAMA by atom transfer radical polymerization (ATRP) gave reasonably low polydispersities as judged by aqueous gel permeation chromatography. A wide range of sugar-based block copolymers were prepared using near-monodisperse macroinitiators based on poly(ethylene oxide) [PEO], poly(propylene oxide) [PPO], or poly(e-caprolactone) [PCL] and/or by sequential monomer addition of other methacrylic monomers such as 2-(diethylamino)ethyl methacrylate [DEA], 2-(diisopropylaminoethyl methacrylate [DPA], or glycerol monomethacrylate [GMA]. The reversible micellar self-assembly of selected sugar-based block copolymers [PEO23-GAMA50-DEA100, PEO23-LAMA30-DEA50, PPO33-GAMA50, and PPO33-LAMA50] was studied in aqueous solution as a function of pH and temperature using dynamic light scattering, transmission electron microscopy, surface tensiometry, and 1H NMR spectroscopy.
authors: School of Chemistry, Physics and Environmental Science, Sussex University, Falmer, Brighton, East Sussex, BN1 9QJ United Kingdom.
authors: Ravin
authors: R
authors: Narain
authors: Steven P
authors: SP
authors: Armes
mesh_terms: D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry; D016503:Drug Delivery Systems; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D015394:Molecular Structure; D011109:Polymethacrylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D012995:Solubility; D012996:Solutions; D013500:Surface Tension; D013696:Temperature
chemical_list: D002241:Carbohydrates; D008823:Micelles; D011109:Polymethacrylic Acids; D012996:Solutions