Molecular mechanism of ureteric bud development.
The urinary collecting system is derived from an epithelial protrusion arising from the Wolffian duct called the ureteric bud (UB) by the signal from its inductive tissue, metanephric mesenchyme (MM). Targeted gene mutation studies have shown that several transcription factors and MM-secreted glial cell line-derived neurotrophic factor (GDNF) are critical for initiation of the UB. After initiation, the UB undergoes branching morphogenesis. Results obtained from in vitro culture systems, including an isolated UB culture, together with gene mutation studies suggest that interplay of multiple positive and negative soluble factors as well as extracellular matrix (ECM) and matrix-degrading proteinases regulate branching morphogenesis.
Sakurai
Hiroyuki
H
Division of Nephrology-Hypertension, Department of Medicine, University of California, San Diego, 9500 Gilman Drive 0693, La Jolla, CA 92093-0693, USA. hsakurai@ucsd.edu
D000818:Animals; D019521:Body Patterning; D002352:Carrier Proteins / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000378:metabolism; D051100:Glial Cell Line-Derived Neurotrophic Factor; D017228:Hepatocyte Growth Factor / Q000378:metabolism; D006801:Humans; D008648:Mesoderm / Q000378:metabolism; D008954:Models, Biological; D009154:Mutation; D009414:Nerve Growth Factors / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism; D014513:Ureter / Q000196:embryology* / Q000378:metabolism
D002352:Carrier Proteins; D016207:Cytokines; C495039:GDNF protein, human; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; C066845:pleiotrophin; D005346:Fibroblast Growth Factors; D017228:Hepatocyte Growth Factor