title: FDG-PET scanning after radiation can predict tumor regrowth three months later.
abstract: OBJECTIVE
  Positron emission tomography (PET) with 2-[(18)F]fluoro-2-deoxy-D-glucose (FDG) is well known for providing excellent clinical information regarding malignant tumors. We investigated whether dual-time FDG-PET performed immediately post radiation could predict early regrowth of malignant tumors.
  
  
  METHODS
  Twenty patients with malignant tumors were included in this study. All patients received radiation, and each underwent FDG-PET before the initiation of therapy and within 10 days of completing their course of irradiation. PET images after irradiation were obtained at 60 min and 180 min post FDG injection. For 26 lesions in 20 patients, standardized uptake value (SUV) before and after treatment was calculated and then correlated with postradiation tumor response and outcome at 3 months status post irradiation.
  
  
  RESULTS
  Retention index [RI = (SUV on delayed image - SUV on early image)/SUV on early image] after irradiation showed a significant difference between patients with residual tumor and those without residual tumor at 3 months status post irradiation (p < 0.0025). All 9 lesions in 6 patients with residual tumors showed more than 0.1 of RI, whereas none of the lesions with less than 0.1 of RI revealed residual tumors.
  
  
  CONCLUSIONS
  Dual-time FDG-PET imaging just after irradiation is potentially useful for predicting early regrowth of malignant tumors.
authors: Department of Radiology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan.
authors: Izumi
authors: I
authors: Koike
authors: Motoko
authors: M
authors: Ohmura
authors: Masaharu
authors: M
authors: Hata
authors: Nobukazu
authors: N
authors: Takahashi
authors: Takashi
authors: T
authors: Oka
authors: Ichiro
authors: I
authors: Ogino
authors: Jin
authors: J
authors: Lee
authors: Tomoko
authors: T
authors: Umezawa
authors: Kazuhiro
authors: K
authors: Kinbara
authors: Kiichi
authors: K
authors: Watai
authors: Yukihiko
authors: Y
authors: Ozawa
authors: Tomio
authors: T
authors: Inoue
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging*; D018365:Neoplasm, Residual; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18