Frontal behavioral syndromes and functional status in probable Alzheimer disease.
OBJECTIVE
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METHODS
The authors used the Frontal Systems Behavior Scale (FrSBe) to determine the frequency of frontal behavioral syndromes in 49 subjects with mild-to-moderate dementia and 23 subjects with severe dementia of Alzheimer disease (AD) and 23 healthy control (HC) participants.


RESULTS
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CONCLUSIONS
Frontal behavior syndromes occurred with higher frequency in AD. Apathy and executive dysfunction were elevated both in mild-to-moderate and severe AD. Disinhibition was elevated only in severe AD. In AD, apathy was associated with difficulty in basic activities of daily living (ADL), whereas executive dysfunction was related to impairment in instrumental ADLs.
Stout
Julie C
JC
Department of Psychology, Indiana University, Bloomington, IN 47405-7007, USA. jcstout@indiana.edu
Wyman
Mary F
MF
Johnson
Shannon A
SA
Peavy
Guerry M
GM
Salmon
David P
DP
D000203:Activities of Daily Living; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000503:physiopathology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis* / Q000503:physiopathology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires