[Expression of multidrug resistance-associated protein 1 in osteosarcoma and its relationship with clinicopathologic characteristics].
OBJECTIVE
To detect the expression of multidrug resistance-associated protein 1 (MRP1) in human ostesarcoma and to explore its relationship with clinicopathologic characteristics.


METHODS
Six normal bone specimens and 45 osteosarcomas from patients were analysed for MRP1 expression by immunohistochemistry. The expression levels of MRP1 with the clinicopathologic parameters of the patients were examined using Chisquare test.


RESULTS
The expression of MRP1 was observed in 32 (71.11%) osteosarcoma specimens. More(P < 0.05) specimens expressed MRP1 in high-grade osteosarcomas(30/38, 78.95%) than in low-grade osteosarcomas (2/7, 28.57%). The correlation coefficient between expression of MRP1 and grade of pathology was 0.844. In a limited number of patients, the expression of MRP1 was not related to the the age and sex of the patients, Enneking surgical stage, osteosarcoma size, serum concentration of ALP and duration before diagnosis. No expression of MRP1 in 6 normal bone specimens was observed.


CONCLUSIONS
MRP1 is expressed in osteosarcoma and its expression is positively correlated with the malignancy of osteosarcoma.
Tu
Chongqi
C
Department of Orthopaedic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Tian
Yonggang
Y
Pei
Fuxing
F
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis*; D000135:Acid Phosphatase / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000737:chemistry* / Q000473:pathology; D002648:Child; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000737:chemistry* / Q000473:pathology
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000135:Acid Phosphatase