title: Restenosis following balloon dilation of benign esophageal stenosis.
abstract: OBJECTIVE
  To elucidate the mechanism of restenosis following balloon dilation of benign esophageal stenosis.
  
  
  METHODS
  A total of 49 rats with esophageal stenosis were induced in 70 rats using 5 ml of 50% sodium hydroxide solution and the double-balloon method, and an esophageal restenosis (RS) model was developed by esophageal stenosis using dilation of a percutaneous transluminal coronary angioplasty (PTCA) balloon catheter. These 49 rats were divided into two groups: rats with benign esophageal stricture caused by chemical burn only (control group, n=21) and rats with their esophageal stricture treated with balloon catheter dilation (experimental group, n=28). Imaging analysis and immunohistochemistry were used for both quantitative and qualitative analyses of esophageal stenosis and RS formation in the rats, respectively.
  
  
  RESULTS
  Cross-sectional areas and perimeters of the esophageal mucosa layer, muscle layer, and the entire esophageal layers increased significantly in the experimental group compared with the control group. Proliferating cell nuclear antigen (PCNA) was expressed on the 5th day after dilation, and was still present at 1 month. Fibronectin (FN) was expressed on the 1st day after dilation, and was still present at 1 month.
  
  
  CONCLUSIONS
  Expression of PCNA and FN plays an important role in RS after balloon dilation of benign esophageal stenosis.
authors: Department of Radiology, Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200233, China. chengys@sh163.net
authors: Ying-Sheng
authors: YS
authors: Cheng
authors: Ming-Hua
authors: MH
authors: Li
authors: Ren-Jie
authors: RJ
authors: Yang
authors: Hui-Zhen
authors: HZ
authors: Zhang
authors: Zai-Xian
authors: ZX
authors: Ding
authors: Qi-Xin
authors: QX
authors: Zhuang
authors: Zhi-Ming
authors: ZM
authors: Jiang
authors: Ke-Zhong
authors: KZ
authors: Shang
mesh_terms: D000818:Animals; D002404:Catheterization; D004940:Esophageal Stenosis / Q000378:metabolism / Q000473:pathology* / Q000628:therapy*; D004947:Esophagus / Q000378:metabolism / Q000473:pathology; D005353:Fibronectins / Q000378:metabolism; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology; D009130:Muscle, Smooth / Q000378:metabolism / Q000473:pathology; D011183:Postoperative Complications / Q000378:metabolism / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012008:Recurrence
chemical_list: D005353:Fibronectins; D018809:Proliferating Cell Nuclear Antigen