Activation and suppression of the proinflammatory immune response by Vibrio cholerae toxins.
Vibrio cholerae induces either non-inflammatory diarrhea or inflammatory gastroenteritis, depending on the presence of cholera toxin, a fluid secretion inducer and a modulator of host immunity. In the absence of cholera toxin, other toxins induce inflammation, resulting in gastroenteritis. Thus, multiple toxins likely affect the safety of live attenuated vaccines.
Satchell
Karla J Fullner
KJ
Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Morton 6-626, Chicago, IL 60611,USA. k-fullner@northwestern.edu
D000818:Animals; D002771:Cholera / Q000276:immunology* / Q000503:physiopathology; D002772:Cholera Toxin / Q000494:pharmacology*; D022121:Cholera Vaccines / Q000009:adverse effects*; D006801:Humans; D007107:Immune System / Q000187:drug effects*; D007249:Inflammation / Q000209:etiology; D014734:Vibrio cholerae / Q000737:chemistry* / Q000145:classification / Q000276:immunology / Q000472:pathogenicity
D022121:Cholera Vaccines; D002772:Cholera Toxin