Angiogenesis in nervous system disorders.
Angiogenesis is a crucial requirement for embryonal development and new vessel formation during adult life. Various disease processes such as cancer, ischemia, vascular malformations, and inflammatory processes also depend on pathological angiogenesis. A better understanding of the complex and coordinated interactions among various angiogenic pathways involved in pathological angiogenesis is necessary to improve our therapeutic approaches to the various disease processes observed in the central nervous system. This review summarizes the current understanding of the role of principal angiogenic factors relevant to neurosurgical abnormalities.
Zadeh
Gelareh
G
Arthur & Sonia Labatts Brain Tumor Center, Hospital for Sick Children's Research Institute, University of Toronto, Toronto, Ontario, Canada.
Guha
Abhijit
A
D043924:Angiogenesis Modulating Agents / Q000494:pharmacology; D042501:Angiogenic Proteins / Q000502:physiology; D006801:Humans; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D009420:Nervous System / Q000098:blood supply*; D009422:Nervous System Diseases / Q000503:physiopathology*
D043924:Angiogenesis Modulating Agents; D042501:Angiogenic Proteins