title: Neuropathological characterisation of French bovine spongiform encephalopathy cases.
abstract: Bovine spongiform encephalopathy (BSE) in cattle is a neurodegenerative disease belonging to the transmissible spongiform encephalopathies, a group of diseases including sheep scrapie and human Creutzfeldt-Jakob disease. The pathological characteristics of BSE are vacuolation, mild gliosis, little neuronal degeneration without inflammatory process and abnormal prion protein (PrPsc) accumulation. The aim of this study was to define precisely the neuropathology of BSE in French cases by assessing the distributions of vacuolar lesions and PrPsc within cattle brains. We showed that vacuolation and PrPsc accumulation varied from one structure to the other, and most often coexisted. These distributions were in accordance with British and Portuguese data previously published. Seven types of PrPsc immunolabelling were described based on morphology and localisation. Besides mild gliosis mainly associated with vacuolation, we observed a very slight neuronal apoptosis. In addition, we saw a moderate vimentin labelling colocalised with vacuolation, a discrete ubiquitin staining and no Tau protein staining. This study provides precise histopathological data that will be completed with a quantitative study on more than 100 obex samples of French BSE cases.
authors: Laboratoire d'Etudes et de Recherches en Pathologie Bovine et Hygiène des Viandes, Unité Virologie-ATNC, AFSSA Lyon, 31 avenue Tony Garnier, 69364 Lyon cedex 07, France.
authors: Sabine
authors: S
authors: Debeer
authors: Thierry
authors: T
authors: Baron
authors: Anna
authors: A
authors: Bencsik
mesh_terms: D000686:Amyloidosis / Q000473:pathology; D000818:Animals; D017209:Apoptosis; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000378:metabolism / Q000473:pathology*; D005260:Female; D009457:Neuroglia / Q000473:pathology; D011328:Prions / Q000378:metabolism; D025801:Ubiquitin / Q000378:metabolism; D014617:Vacuoles / Q000473:pathology; D014746:Vimentin / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism
chemical_list: D011328:Prions; D025801:Ubiquitin; D014746:Vimentin; D016875:tau Proteins