title: Gastrointestinal hormone secretion after surgery in neonates with congenital intestinal anomalies during starvation and introduction of enteral nutrition.
abstract: OBJECTIVE
  Gastrointestinal hormones modulate gut function in response to enteral nutrition. Infants with a congenital intestinal anomaly with loss of bowel length either pre-or postnatal, who are on total parenteral nutrition for prolonged periods after surgery, are especially prone to a disturbed secretion of gut hormones. The aim of this study was to determine whether circulating gut hormones were altered in these patients and to collect baseline data for future studies in short bowel patients using different enteral substrates.
  
  
  METHODS
  Gastrin, cholecystokinin, and peptide YY were measured in 14 operated neonates who had a congenital intestinal anomaly during starvation and introduction of enteral nutrition. None of the neonates had a short bowel. Fourteen neonates who underwent surgery for other major congenital anomalies served as age-matched controls. Gut hormones were measured with radioimmunoassays.
  
  
  RESULTS
  Postprandial gut hormone values were higher than basal gut hormone values within both groups. Compared with the controls, postprandial gastrin and cholecystokinin were significantly higher in the patients.
  
  
  CONCLUSIONS
  Neonates with a congenital intestinal anomaly in the absence of a short bowel have a similar secretion pattern of gastrointestinal hormones as neonates with a structurally normal intestinal tract, both during starvation and enteral nutrition.
authors: Department of Pediatric Surgery, Sophia Children's Hospital, Rotterdam, The Netherlands.
authors: M
authors: M
authors: Sharman-Koendjbiharie
authors: M
authors: M
authors: Piena-Spoel
authors: W P M
authors: WP
authors: Hopman
authors: M J I J
authors: MJ
authors: Albers
authors: J B M J
authors: JB
authors: Jansen
authors: D
authors: D
authors: Tibboel
mesh_terms: D000714:Anastomosis, Surgical; D002766:Cholecystokinin / Q000378:metabolism*; D003125:Colostomy; D004064:Digestive System / Q000378:metabolism*; D004750:Enteral Nutrition; D005508:Food Deprivation; D005755:Gastrins / Q000378:metabolism*; D006801:Humans; D007081:Ileostomy; D007231:Infant, Newborn; D007422:Intestines / Q000002:abnormalities* / Q000601:surgery; D007582:Jejunostomy; D019894:Peptide YY / Q000378:metabolism*; D012636:Secretory Rate
chemical_list: D005755:Gastrins; D019894:Peptide YY; D002766:Cholecystokinin