title: Intraocular oxygen tensions in normal and diseased eyes of farmed halibut.
abstract: We have previously documented ocular abnormalities in farmed halibut and reported that the production of gas-filled posterior segment cysts appears to be central in the pathogenesis of many, if not all of the signs in these eyes. In a number of fish, gas bubbles may be seen in the anterior chamber of the eye, especially after trauma or strenuous exertion associated with handling. A knowledge of the composition of this gas is important in understanding fully the mechanism of gas and cyst production. Here we report investigations into the composition of gas in the globes of normal fish, fish in which intraocular cysts have been documented previously by ultrasonography and fish where post-mortem examination demonstrated both gas- and fluid-filled choroidal cysts. High levels of oxygen were demonstrated in samples of aqueous from all fish but fish with affected eyes had a statistically significantly higher partial pressure of oxygen than did fish with normal eyes.
authors: Department of Clinical Veterinary Medicine, Madingley Road, Cambridge CB3 OES, UK. doctordlwilliams@aol.com
authors: D L
authors: DL
authors: Williams
authors: W M
authors: WM
authors: Brancker
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000473:pathology / Q000502:physiology; D017756:Aquaculture; D003560:Cysts / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D005123:Eye / Q000473:pathology* / Q000503:physiopathology; D005128:Eye Diseases / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D005393:Fish Diseases / Q000209:etiology / Q000473:pathology*; D005432:Flounder; D007429:Intraocular Pressure; D010100:Oxygen / Q000378:metabolism*
chemical_list: D010100:Oxygen