title: Contribution of hematopoietic stem cells to skeletal muscle.
abstract: Cells from adult bone marrow participate in the regeneration of damaged skeletal myofibers. However, the relationship of these cells with the various hematopoietic and nonhematopoietic cell types found in bone marrow is still unclear. Here we show that the progeny of a single cell can both reconstitute the hematopoietic system and contribute to muscle regeneration. Integration of bone marrow cells into myofibers occurs spontaneously at low frequency and increases with muscle damage. Thus, classically defined single hematopoietic stem cells can give rise to both blood and muscle.
authors: The Biomedical Research Centre, University of British Columbia, 2222 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada.
authors: Stéphane Y
authors: SY
authors: Corbel
authors: Adrienne
authors: A
authors: Lee
authors: Lin
authors: L
authors: Yi
authors: Jeffrey
authors: J
authors: Duenas
authors: Timothy R
authors: TR
authors: Brazelton
authors: Helen M
authors: HM
authors: Blau
authors: Fabio M V
authors: FM
authors: Rossi
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018485:Muscle Fibers, Skeletal / Q000166:cytology; D018482:Muscle, Skeletal / Q000166:cytology* / Q000502:physiology; D012038:Regeneration