Papular neutrophilic dermatosis and erythema elevatum diutinum following erythropoietin therapy in a patient with myelodysplastic syndrome.
A 65-year-old man with refractory anaemia with an excess of blasts developed an erythematous papular eruption symmetrically distributed on the legs and trunk 3 months after initiation of erythropoietin therapy. The lesions showed a dense neutrophilic infiltrate in the absence of leucocytoclastic vasculitis, and did not fit the criteria of a well-defined neutrophilic dermatosis. Concomitant with the rapid resolution of these skin lesions following erythropoietin discontinuation, typical lesions of erythema elevatum diutinum arose on the extensor surface of the fingers, knees and elbows, which responded to a brief course of dapsone treatment. Although typical and atypical neutrophilic dermatoses have been reported in patients with haematological disorders, they have also been associated with the use of drugs, in particular granulocyte colony-stimulating factor. To our knowledge this is the first report of unclassified neutrophilic dermatosis and erythema elevatum diutinum occurring following the administration of erythropoietin.
Gubinelli
Emanuela
E
Istituto Dermopatico dell'Immacolata, IRCCS, Rome, Italy.
Cocuroccia
Barbara
B
Fazio
Marcello
M
Annessi
Giorgio
G
Girolomoni
Giampiero
G
D000368:Aged; D003115:Colony-Stimulating Factors / Q000009:adverse effects*; D004890:Erythema / Q000139:chemically induced* / Q000276:immunology; D004921:Erythropoietin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000188:drug therapy*; D020556:Neutrophil Infiltration / Q000187:drug effects* / Q000276:immunology
D003115:Colony-Stimulating Factors; D004921:Erythropoietin