title: Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist.
abstract: A new series of hPPARalpha agonists containing a 2,4-dihydro-3H-1,2,4-triazol-3-one (triazolone) core is described leading to the discovery of 5 (LY518674), a highly potent and selective PPARalpha agonist.
authors: Division of Eli Lilly & Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.
authors: Yanping
authors: Y
authors: Xu
authors: Daniel
authors: D
authors: Mayhugh
authors: Ashraf
authors: A
authors: Saeed
authors: Xiaodong
authors: X
authors: Wang
authors: Richard C
authors: RC
authors: Thompson
authors: Samuel J
authors: SJ
authors: Dominianni
authors: Raymond F
authors: RF
authors: Kauffman
authors: Jaipal
authors: J
authors: Singh
authors: James S
authors: JS
authors: Bean
authors: William R
authors: WR
authors: Bensch
authors: Robert J
authors: RJ
authors: Barr
authors: John
authors: J
authors: Osborne
authors: Chahrzad
authors: C
authors: Montrose-Rafizadeh
authors: Richard W
authors: RW
authors: Zink
authors: Nathan P
authors: NP
authors: Yumibe
authors: Naijia
authors: N
authors: Huang
authors: Debra
authors: D
authors: Luffer-Atlas
authors: Deepa
authors: D
authors: Rungta
authors: Dale E
authors: DE
authors: Maise
authors: Nathan B
authors: NB
authors: Mantlo
mesh_terms: D000284:Administration, Oral; D000818:Animals; D016632:Apolipoprotein A-I / Q000235:genetics; D001667:Binding, Competitive; D001682:Biological Availability; D002460:Cell Line; D004285:Dogs; D015195:Drug Design; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011869:Radioligand Assay; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists*; D013329:Structure-Activity Relationship; D014157:Transcription Factors / Q000819:agonists* / Q000378:metabolism; D014162:Transfection; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D016632:Apolipoprotein A-I; C479889:LY 518674; D011422:Propionates; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D014230:Triazoles