title: Long-term follow-up of pediatric en bloc renal transplantation.
abstract: We reviewed the outcomes of pediatric en bloc renal transplantation at two Canadian centers in the cyclosporine era. Between 1984 and 2002, 16 patients received pediatric en bloc renal transplants. Mean recipient age and weight were 45 +/- 17 years and 72.2 +/- 14.4 kg, respectively. En bloc kidneys were procured from donors aged 2.1 +/- 0.8 years (range, 0.7 to 4.0), weighing an average of 14.3 +/- 2.0 kg (range, 12 to 17). All en bloc kidneys were successfully transplanted without thrombosis. All patients received calcineurin inhibitors and corticosteroids. Only three patients received antibody-based induction therapy. Rejection episodes occurring in seven grafts were all successfully treated. Mean follow-up was 3.7 years (range 0.4 to 15.0). Mean serum creatinine values at 3 months and 1 and 3 years were 138.8 +/- 54.5 micromol/L, 118.6 +/- 38.1 micromol/L, and 95.1 +/- 24.4 micromol/L, respectively. The mean creatinine value of five patients with at least 5 years follow-up was 96.8 +/- 12.3 micromol/L. Three-year graft and patient survival rates were 94%. Two deaths with functioning grafts occurred secondary to cardiac and infectious etiologies. None of the grafts were lost independent of death. We conclude that en bloc transplantation has excellent short- and long-term results. Improving graft function after 3 years represented by reduced serum creatinine suggests that these kidneys have excellent renal reserve and growth potential.
authors: Multi-Organ Transplant Program, London Health Sciences Centre, the University of Western Ontario, London, Ontario, Canada.
authors: K A
authors: KA
authors: Beasley
authors: F
authors: F
authors: Balbontin
authors: A
authors: A
authors: Cook
authors: M
authors: M
authors: Bloch
authors: V C
authors: VC
authors: McAlister
authors: J
authors: J
authors: Lawen
authors: P P W
authors: PP
authors: Luke
mesh_terms: D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D016030:Kidney Transplantation / Q000379:methods* / Q000401:mortality / Q000502:physiology*; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D003404:Creatinine