Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease.
In its late stage, Alzheimer's disease results in progressive muscle weakness in the arms and legs. The aim of this study was to determine whether mice expressing the skeletal muscle-specific mutant PS2 gene (a model of Alzheimer's disease) are a useful experimental system to study the protective effect of exercise on A beta-42 reduction, improvement of behavioural function and changes in metabolic parameters. With this aim in mind, the transgenic mice were subjected to treadmill exercise for 3 months. The results showed that in transgenic mice, but not in normal mice, treadmill exercise resulted in a reduction of A beta-42 deposits and an improvement in behavioural function, thereby restoring normal concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride. Thus, exercise may represent a practical therapeutic strategy for use with human patients with Alzheimer's disease.
Cho
Jun Y
JY
Division of Laboratory Animal Resources, National Institute of Toxicological Research, Korea FDA, Seoul 122-704, Korea.
Hwang
Dae Y
DY
Kang
Tae S
TS
Shin
Dong H
DH
Hwang
Jin H
JH
Lim
Chae H
CH
Lee
Su H
SH
Lim
Hwa J
HJ
Min
Sae H
SH
Seo
Su J
SJ
Song
Youn S
YS
Nam
Ki T
KT
Lee
Kyu S
KS
Cho
Jung S
JS
Kim
Yong K
YK
D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D018482:Muscle, Skeletal / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000235:genetics*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D053766:Presenilin-2; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008565:Membrane Proteins; C508861:PSEN2 protein, human; D053766:Presenilin-2; D014280:Triglycerides; D002784:Cholesterol; D010751:Phosphopyruvate Hydratase