title: Development of an IL-6 antagonist peptide that induces apoptosis in 7TD1 cells.
abstract: Interleukin-6 (IL-6) is a pleiotropic cytokine involved in the regulation of proliferation and differentiation of hematopoietic cells and in the pathogenesis of many diseases, including multiple myeloma. This study pursues a way to interfere with IL-6 pathway in an attempt to modulate its biological activity. Here we describe the rational design and biological evaluation of peptides able to antagonize the murine IL-6 activity by interfering with IL-6 Receptor alpha in 7TD1 cells, a IL-6-dependent B-cell line. Of the peptide tested, only Guess 4a is capable of interfering with IL-6 transducing pathway, therefore inducing growth arrest and apoptosis of 7TD1 cells.
authors: Sezione di Chimica Biologica, Dipartimento di Scienze Biomediche, Università degli Studi di Modena e Reggio Emilia, Via Campi 297, 41100, Modena, Italy.
authors: Rossella
authors: R
authors: Manfredini
authors: Elena
authors: E
authors: Tenedini
authors: Michela
authors: M
authors: Siena
authors: Enrico
authors: E
authors: Tagliafico
authors: Monica
authors: M
authors: Montanari
authors: Alexis
authors: A
authors: Grande
authors: Tommaso
authors: T
authors: Zanocco-Marani
authors: Cristina
authors: C
authors: Poligani
authors: Roberta
authors: R
authors: Zini
authors: Claudia
authors: C
authors: Gemelli
authors: Anna
authors: A
authors: Bergamaschi
authors: Tatiana
authors: T
authors: Vignudelli
authors: Francesca
authors: F
authors: De Rienzo
authors: Pier Giuseppe
authors: PG
authors: De Benedetti
authors: Maria Cristina
authors: MC
authors: Menziani
authors: Sergio
authors: S
authors: Ferrari
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D001402:B-Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D019295:Computational Biology; D003198:Computer Simulation; D015850:Interleukin-6 / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D010455:Peptides / Q000494:pharmacology*; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D000093242:Interleukin-6 Inhibitors
chemical_list: D015850:Interleukin-6; D010455:Peptides; D000093242:Interleukin-6 Inhibitors