title: Modulatory serotonin receptors on the soma of command neurons in edible snail.
abstract: Local application of serotonin (5-hydroxytryptamine, 5-HT) to the soma of command neurons LPa2, LPa3, PPa3, and PPa2 of edible snail Helix lucorum reversibly decreased acetylcholine-induced inward current in these neurons. NAN-190 and methiothepin, antagonists of 5-HT1 serotonin receptors, prevented this modulatory effect of 5-HT. By contrast, LY-53.857, ICS-205.930, and SDZ-205.557, antagonists of 5-HT2, 5-HT3, and 5-HT4 serotonin receptors, respectively, produced no effect on the modulatory effect of serotonin. The data confirm the presence of modulator 5-HT1 serotonin receptor on the soma of command neurons of Helix pomatia.
authors: Department of Higher Nervous Activity, M. V. Lomonosov Moscow State University.
authors: A S
authors: AS
authors: Pivovarov
authors: V L
authors: VL
authors: Nistratova
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism; D006372:Helix, Snails / Q000033:anatomy & histology / Q000378:metabolism*; D017136:Ion Transport / Q000502:physiology; D008564:Membrane Potentials / Q000502:physiology; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D018408:Patch-Clamp Techniques; D044263:Receptors, Serotonin, 5-HT1 / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D044263:Receptors, Serotonin, 5-HT1; D012702:Serotonin Antagonists; D012701:Serotonin; D000109:Acetylcholine