Risk factors of posthepatectomy liver failure after portal vein embolization.
OBJECTIVE
Major hepatectomy has been successfully performed after portal vein embolization (PE). However, post-hepatectomy liver failure following hyperbilirubinemia (HB) sometimes occurs even after PE. Our objective was to determine what factors affected post-hepatectomy HB and liver failure.


METHODS
Forty-two patients underwent PE before major hepatectomy or repeat hepatic resection after partial hepatectomy. Having a prognostic score over 40, they all belonged to a high-risk group. They were classified into two groups according to post-hepatectomy levels of total bilirubin: normal group and HB group. The HB group was further divided into two subgroups: recovered subgroup and fatal subgroup. We investigated the differences between the two groups and the two subgroups.


RESULTS
Ten of 14 cases (71%) in the HB group were biliary tract disease with jaundice before PE. The indocyanine green retention rate (ICGR15) before PE, skeletonization of the hepatoduodenal ligament (HDL), and portal venous pressure after PE were significantly different between the two groups as shown by multivariate analysis. Postoperative complication was the only factor significantly different between the two subgroups by univariate analysis.


CONCLUSIONS
When the patients underwent major hepatectomy combined with skeletonization of the HDL for biliary tract disease with jaundice, they were subject to post-hepatectomy HB even after PE. If they had postoperative complications, fatal hepatic failure must have occurred.
Fujii
Yoshiro
Y
Second Department of Surgery, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Shimada
Hiroshi
H
Endo
Itaru
I
Morioka
Daisuke
D
Nagano
Yasuhiko
Y
Miura
Yasuhiko
Y
Tanaka
Kuniya
K
Togo
Shinji
S
D000368:Aged; D004067:Digestive System Neoplasms / Q000601:surgery*; D004621:Embolization, Therapeutic / Q000009:adverse effects*; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects*; D006801:Humans; D006932:Hyperbilirubinemia / Q000209:etiology*; D017093:Liver Failure / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D012307:Risk Factors