Antiviral drug-induced kidney and electrolytes disorders.
HIV patients are at a high risk for nephrotoxicity (HIV-induced nephrotoxicity, HIVAN). As a result, renal insufficiency, tubular dysfunction and renal-related biological disorders are frequently observed in those patients. However, in some cases those defects or anomalies in renal function may be related to antiviral therapies rather than the disease itself. This article reviews the incidence, presentation, prevention and management of antiviral drug-induced renal dysfunction.
Izzedine
H
H
Department of Nephrology, Pitie-Salpetriere Hospital, Paris, France. hassan.izzedine@psl.ap-hop-paris.fr
Launay-Vacher
V
V
Isnard-Bagnis
C
C
Deray
G
G
D019380:Anti-HIV Agents / Q000009:adverse effects; D000998:Antiviral Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003586:Cytomegalovirus Infections / Q000188:drug therapy; D006525:Hepatitis, Viral, Human / Q000188:drug therapy; D006561:Herpes Simplex / Q000188:drug therapy; D006562:Herpes Zoster / Q000188:drug therapy; D006801:Humans; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced*
D019380:Anti-HIV Agents; D000998:Antiviral Agents