Antimicrobial resistance of Pseudomonas aeruginosa biofilms.
Resistance to antimicrobial agents is the most important feature of biofilm infections. As a result, infections caused by bacterial biofilms are persistent and very difficult to eradicate. Although several mechanisms have been postulated to explain reduced susceptibility to antimicrobials in bacterial biofilms, it is becoming evident that biofilm resistance is multifactorial. The contribution of each of the different mechanisms involved in biofilm resistance is now beginning to emerge.
Drenkard
Eliana
E
Department of Genetics, Harvard Medical School, Boston, MA 02114, USA. drenkard@molbio.mgh.harvard.edu
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000235:genetics / Q000502:physiology; D018441:Biofilms / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism / Q000502:physiology
D000900:Anti-Bacterial Agents