[Circumstances of choroid and ciliary body melanoma detection].
OBJECTIVE
To report and analyze the circumstances of uveal melanoma detection.


METHODS
The records of 143 consecutive patients diagnosed in the Ophthalmology Department of Gustave Roussy Institute between September 1994 and September 2001 were analyzed. The study included 66 females and 77 males, aged from 21 to 91 years (mean, 62.75 years).


RESULTS
The first symptom was decreased visual acuity in 37% of cases. In 34.9%, there was no functional sign and a systematic fundus exam provided the diagnosis. Of the 143 patients, 18.8% presented alteration of the visual field or scotoma, 9.9% complained of phosphenes, 9% complained of metamorphopsia, and 6.5% complained of floaters. In 5.5% of cases, there was documented tumor growth. In 2%, the presence of extrascleral exteriorization was the first sign. At the time of diagnosis, anterior tumors tended to be significantly larger than posterior tumors (p<0.007). Smaller lesions were significantly associated with a systematic detection of the tumor (p<0.005). Liver metastasis occurred more frequently with ciliary body melanomas (p<0.001), which were more frequently the largest lesions.


CONCLUSIONS
These results emphasize the importance of early detection of uveal melanoma. We recommended frequent fundus examination after pupil dilatation.
Frau
E
E
Service d'Ophtalmologie, CHU de Bicêtre, 78, avenue du Général Leclerc, 94270 Le Kremlin Bicêtre, France.
Lautier-Frau
M
M
Labétoulle
M
M
Coquidet
C
C
Kirsch
O
O
Rumen
F
F
Offret
H
H
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002830:Choroid Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D002924:Ciliary Body; D003937:Diagnosis, Differential; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008297:Male; D008545:Melanoma / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D008875:Middle Aged; D009887:Ophthalmoscopy; D010719:Phosphenes; D011379:Prognosis; D012189:Retrospective Studies; D012607:Scotoma / Q000209:etiology; D017678:Sex Distribution; D013997:Time Factors; D014604:Uveal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D014786:Vision Disorders / Q000209:etiology; D014792:Visual Acuity; D014794:Visual Fields