title: Fas-ligand mediated apoptosis in severe sepsis and shock.
abstract: Alterations in the apoptotic process in lymphoid tissues is a common condition which is encountered in the severely septic animal and critically ill patient. Here we attempt to delineate the pathological significance of these apoptotic changes and the role of Fas-FasL mediated contribution to this process.
authors: Division of Surgical Research, Department of Surgery, Brown University School of Medicine, Rhode Island Hospital, Providence, RI 02903, USA. AAYALA@LIFESPAN.org
authors: Alfred
authors: A
authors: Ayala
authors: Joanne L
authors: JL
authors: Lomas
authors: Patricia S
authors: PS
authors: Grutkoski
authors: Shiang
authors: S
authors: Chung
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology / Q000502:physiology*; D053222:Fas Ligand Protein; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D051379:Mice; D018805:Sepsis / Q000276:immunology / Q000473:pathology*; D012772:Shock, Septic / Q000276:immunology / Q000473:pathology*; D013950:Thymus Gland / Q000473:pathology
chemical_list: C505661:FASLG protein, human; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D008562:Membrane Glycoproteins