title: The objective severity assessment of atopic dermatitis score: an objective measure using permeability barrier function and stratum corneum hydration with computer-assisted estimates for extent of disease.
abstract: OBJECTIVE
  Clinical scores used to assess the severity of atopic dermatitis (AD) rely entirely on subjective criteria to evaluate the severity of lesions and the extent of involvement. The aim of this study was to develop an objective measure of AD severity by measuring stratum corneum (SC) functions and by using computer-assisted estimates of involved body surface areas (BSAs).
  
  
  METHODS
  Barrier function of the SC was assessed by measuring transepidermal water loss, and SC hydration was assessed by measuring capacitance. The extent of disease was assessed using a computer-assisted algorithm.
  
  
  METHODS
  A total of 38 sequential volunteers aged 4 months to 18 years (25 girls, 13 boys) with mild to severe AD at a university outpatient pediatric dermatology clinic.
  
  
  METHODS
  The computer-assisted method for estimating BSA was compared with estimates using the "rule of nines." The Objective Severity Assessment of Atopic Dermatitis (OSAAD) score, derived from measurements of SC barrier function and SC hydration and normalized for extent of disease was compared with the Scoring Atopic Dermatitis (SCORAD) index.
  
  
  RESULTS
  Measurements of epidermal permeability barrier function and SC hydration correlated with clinical estimates of disease severity. The computer-assisted measurements of the extent of disease correlated with estimates derived from the rule of nines. The OSAAD scores correlated with the currently used instrument for AD severity, the SCORAD index.
  
  
  CONCLUSIONS
  The OSAAD is a new AD severity score that avoids the pitfalls of currently used subjective scoring systems by using objective measures.
authors: Departments of Dermatology, University of California, San Francisco 94115, USA.
authors: Jeffrey L
authors: JL
authors: Sugarman
authors: Joachim W
authors: JW
authors: Fluhr
authors: Ashley J
authors: AJ
authors: Fowler
authors: Thomas
authors: T
authors: Bruckner
authors: Thomas L
authors: TL
authors: Diepgen
authors: Mary L
authors: ML
authors: Williams
mesh_terms: D000293:Adolescent; D001830:Body Surface Area; D001834:Body Water / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000378:metabolism / Q000503:physiopathology*; D003936:Diagnosis, Computer-Assisted; D004817:Epidermis / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010539:Permeability; D010865:Pilot Projects; D012720:Severity of Illness Index; D014870:Water Loss, Insensible