The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants.
A previously undetected domain, named CW for its conserved cysteine and tryptophan residues, appears to be a four-cysteine zinc-finger motif found exclusively in vertebrates, vertebrate-infecting parasites and higher plants. Of the twelve distinct nuclear protein families that comprise the CW domain-containing superfamily, only the microrchida (MORC) family has begun to be characterized. However, several families contain other domains suggesting a relationship between the CW domain and either chromatin methylation status or early embryonic development.
Perry
Jason
J
Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.
Zhao
Yunde
Y
D000595:Amino Acid Sequence; D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D017124:Conserved Sequence; D003545:Cysteine / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data; D010271:Parasites / Q000235:genetics* / Q000378:metabolism; D010940:Plant Proteins / Q000235:genetics; D010944:Plants / Q000235:genetics* / Q000378:metabolism; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid; D014364:Tryptophan / Q000737:chemistry; D014714:Vertebrates / Q000235:genetics* / Q000378:metabolism / Q000469:parasitology; D016335:Zinc Fingers / Q000235:genetics*
D002843:Chromatin; D010940:Plant Proteins; D014364:Tryptophan; D003545:Cysteine