title: Prognostic predictors for survival in patients with COPD using cardiopulmonary exercise testing.
abstract: We studied the relationship between physiologic parameters in cardiopulmonary exercise testing (CPET) and prognosis in terms of survival time in patients with chronic obstructive pulmonary disease (COPD) in order to accurately assess the severity of the disease. From a group of 195 patients with COPD who had consecutively undergone CPET between July 1989 and October 1997, we enrolled 120 subjects (mean age 67.6 years, 104 males) with exertional dyspnoea into a cohort protocol. Of these subjects, 34 (28.3%) died during the 3-5-year follow-up period after CPET. By univariate analysis, the following factors were significantly associated with survival time: age, body mass index, %FVC, %FEV1, FEV1%, PaCO2 at rest, severity of exercise-induced hypoxemia evaluated by DeltaPaO2/DeltaVO2 (PaO2-slope), oxygen uptake, ventilation, tidal volume, PaCO2 and oxygen pulse at maximum exercise, as well as prescribing long-term oxygen therapy. By multivariate analysis, age and the PaO2-slope showed significance as independent prognostic factors, and the PaO2-slope was most closely associated with the survival time. These results reveal that CPET is a useful technique to accurately assess the relationship between the functional impairments and the prognosis of patients with COPD.
authors: Department of Internal Medicine, Toneyama National Hospital, Osaka, Japan.
authors: Toru
authors: T
authors: Hiraga
authors: Ryoji
authors: R
authors: Maekura
authors: Yoshinari
authors: Y
authors: Okuda
authors: Takashi
authors: T
authors: Okamoto
authors: Atsushi
authors: A
authors: Hirotani
authors: Seigo
authors: S
authors: Kitada
authors: Kenji
authors: K
authors: Yoshimura
authors: Soichiro
authors: S
authors: Yokota
authors: Masami
authors: M
authors: Ito
authors: Takeshi
authors: T
authors: Ogura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005080:Exercise Test / Q000379:methods* / Q000706:statistics & numerical data*; D005260:Female; D006334:Heart Function Tests / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000401:mortality*; D015203:Reproducibility of Results; D012129:Respiratory Function Tests / Q000379:methods / Q000706:statistics & numerical data; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013534:Survival; D016019:Survival Analysis