title: Superiority of varicella skin test antigen over purified varicella-zoster virus glycoproteins in monitoring booster response to Oka varicella vaccine.
abstract: Varicella skin test antigen has been developed based on the induction of delayed-type hypersensitivity (DTH) to varicella-zoster virus (VZV). The booster immune response to Oka varicella vaccine was assessed by cutaneous reactivity to purified VZV glycoprotein complexes, gB, gE:gI, gH:gL, and varicella skin test antigen. Skin tests with these antigens significantly augmented antibody production to glycoproteins and VZV antigen resulting in no further augmentation by the subsequent vaccination. All glycoprotein complexes induced the cutaneous reaction similarly to varicella skin test antigen. Cutaneous reaction to glycoproteins and varicella skin test antigen was boosted after vaccination. However, the magnitude of cutaneous reaction to each glycoprotein complex before and after vaccination was rich in variety. These results indicated that skin test with varicella skin test antigen is a more suitable indicator in monitoring cell-mediated immunity to VZV than that using purified glycoproteins.
authors: Department of Virology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194 Toyama, Japan.
authors: Hitoshi
authors: H
authors: Sato
authors: Jun ichi
authors: Ji
authors: Yamamura
authors: Seiji
authors: S
authors: Kageyama
authors: Masahiko
authors: M
authors: Kurokawa
authors: Kimiyasu
authors: K
authors: Shiraki
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis; D000956:Antigens, Viral / Q000276:immunology*; D002644:Chickenpox / Q000175:diagnosis* / Q000276:immunology*; D019433:Chickenpox Vaccine / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006023:Glycoproteins / Q000276:immunology*; D014645:Herpesvirus 3, Human / Q000737:chemistry*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007117:Immunization, Secondary; D008297:Male; D012882:Skin Tests
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D019433:Chickenpox Vaccine; D006023:Glycoproteins