title: Determination of serum C-reactive protein (CRP) in healthy beagle dogs of various ages and pregnant beagle dogs.
abstract: Serum C-reactive protein (CRP) concentrations in healthy beagle dogs of various ages and in pregnant beagles were measured by enzyme-linked immunosorbent assay (ELISA). Serum CRP concentrations were 1.5-16.0 microg/ml (mean 7.9 +/- 3.4 microg/ml) in male, and 1.8-18.9 microg/ml (mean 8.3 +/- 4.0 microg/ml) in female dogs. No significant sex-related differences were observed in the values. Further, there were no significant age-related differences either. Serum CRP concentrations increased during pregnancy. The concentration of serum CRP in pregnant dogs peaked at 70.2-90.4 microg/ml (mean 77.5 +/- 7.1 microg/ml) 30 or 45 days after ovulation, demonstrating two characteristic features of CRP concentration change in pregnant dogs.
authors: Laboratory of Immunology, College of Environmental and Health Sciences, Azabu University, Sagamihara, Kanagawa, Japan.
authors: Takashi
authors: T
authors: Kuribayashi
authors: Tokihiro
authors: T
authors: Shimada
authors: Mariko
authors: M
authors: Matsumoto
authors: Katsuhito
authors: K
authors: Kawato
authors: Toshio
authors: T
authors: Honjyo
authors: Masafumi
authors: M
authors: Fukuyama
authors: Yutaka
authors: Y
authors: Yamamoto
authors: Shizuo
authors: S
authors: Yamamoto
mesh_terms: D000375:Aging / Q000097:blood*; D000818:Animals; D002097:C-Reactive Protein / Q000032:analysis*; D004285:Dogs / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000097:blood*
chemical_list: D002097:C-Reactive Protein