title: Derivatized amino acids relevant to native peptide synthesis by chemical ligation and acyl transfer.
abstract: Three amino acids were converted into the derivatives 5.2 (from glycine), 6.4a and 6.4b (from alanine), and 8.3a and 8.3b (from O-benzyl serine). These N-alkylated amino acids, which can be deprotected after conversion of the carboxyl into an amide, correspond to the general structure 2.1, a compound class of use in the study of peptide segment coupling by the ligation-acyl transfer method.
authors: Chemistry Department, University of Alberta, Edmonton, Alberta, Canada T6G 2G2. derrick.clive@ualberta.ca
authors: Derrick L J
authors: DL
authors: Clive
authors: Soleiman
authors: S
authors: Hisaindee
authors: Don M
authors: DM
authors: Coltart
mesh_terms: D000215:Acylation; D000409:Alanine / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D005998:Glycine / Q000737:chemistry; D008026:Ligation; D008956:Models, Chemical; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D012694:Serine / Q000737:chemistry
chemical_list: D000596:Amino Acids; D010455:Peptides; D012694:Serine; D000409:Alanine; D005998:Glycine