Clinical characteristics of 195 Japanese sarcoidosis patients treated with oral corticosteroids.
Questionnaires were sent to 46 hospitals of all over Japan in order to obtain the clinical data on sarcoidosis patients who were treated with oral corticosteroids. The number of female patients was greater than that of male patients (1.5:1), and the average age was 44.9 +/- 16.5 with peaks at 20 and at 50 to 60. The markers of disease activity were high in serum or bronchoalveolar lavage fluids (BALF): specifically, the serum angiotensin-converting enzyme (sACE) was 27.9 +/- 31.9 IU/ml (n.v. < 21.4), and the CD4/CD8 lymphocyte ratio was 6.5 +/- 5.7. Eye involvement was the most common reason for systemic steroid therapy, followed in order by lung and heart involvement. The main reasons for steroid therapy were the exacerbation of ocular symptoms, visual disturbance, respiratory symptoms, such as cough or exertional dyspnea, progression of chest radiographic findings, heart failure and severe arrhythmia, such as AV block. The initial corticosteroid dose was usually 30 mg of predinisolone per day, but for some refractory cases, a 40-60 mg per day was used. Immunosuppressive drugs, such as methotrexate, were also used in the small number of patients who responded poorly to the steroid. Overall, a good clinical response to the drug was found in 70-80% of the steroid treated patients, but in those with cardiac disease, the response rate was only 48%.
Sugisaki
Katsunori
K
Division of Pulmonary Disease, Department of Allergy and Immunology, Oita Medical University, Hazama-machi, Japan. sugisaki@oita-med.ac.jp
Yamaguchi
Tetsuo
T
Nagai
Sonoko
S
Ohmiti
Mitsuhide
M
Takenaka
Sinobu
S
Morimoto
Sin'ichiro
S
Ishihara
Mami
M
Tachibana
Teruo
T
Tsuda
Tomiyasu
T
D000284:Administration, Oral; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D004334:Drug Administration Schedule; D005260:Female; D006306:Health Surveys; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D012507:Sarcoidosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D012737:Sex Factors; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D007703:Peptidyl-Dipeptidase A