title: Use of selenium-bound resin for the solid-phase synthesis of substituted isoxazolyl-substituted (E)-olefins.
abstract: [reaction: see text] The preparation of isoxazolyl- and isoxazolinyl-substituted olefins, based on polystyrene-supported selenenyl bromide, is described. Key steps include 1,3-dipolar cycloadditions and the alpha-alkylation reaction of selenium resins. The polystyrene-supported selenium resins used here not only facilitate separation of products, but also assist the crucial reaction of alpha-alkylation and selenoxide syn-elimination, which ensures the purity of the products.
authors: Department of Chemistry, Zhejiang University (Campus Xixi), Hangzhou, 310028, Peoples Republic of China. huangx@mail.hz.zj.cn
authors: Xian
authors: X
authors: Huang
authors: Wei-Ming
authors: WM
authors: Xu