Incorporation of vancomycin-supplemented bone incorporation of vancomycin-supplemented bone allografts: radiographical, histopathological and immunohistochemical study in pigs.
We compared the incorporation of bone allografts with or without vancomycin in tibial defects of 18 pigs. High-quality radiographs, histological examination, immunological expression of metalloproteinase-13 (MMP-13) and transforming growth factor-beta 2 (TGFbeta2) indicated that there was no significant difference in bone allograft incorporation between up to 220 times the MIC (minimum inhibitory concentration) in bone allografts with 1 g of vancomycin in each 300 g of allograft or without this supplement.
Buttaro
Martin A
MA
Institute of Orthopaedics Carlos E. Ottolenghi, Hospital ltaliano de Buenos Aires, Argentina. cadera@hospitalitaliano.org.ar
González Della Valle
Alejandro M
AM
Piñeiro
Laura
L
Mocetti
Esteban
E
Morandi
Ana A
AA
Piccaluga
Francisco
F
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016025:Bone Transplantation / Q000473:pathology*; D017364:Collagenases / Q000378:metabolism; D005355:Fibrosis; D007150:Immunohistochemistry; D008297:Male; D053509:Matrix Metalloproteinase 13; D009336:Necrosis; D013552:Swine; D013977:Tibia / Q000473:pathology / Q000637:transplantation; D016212:Transforming Growth Factor beta / Q000378:metabolism; D053781:Transforming Growth Factor beta2; D014640:Vancomycin / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D016212:Transforming Growth Factor beta; D053781:Transforming Growth Factor beta2; D014640:Vancomycin; D017364:Collagenases; D053509:Matrix Metalloproteinase 13