[Rational therapeutic regime of glucocorticoid in patients with acute respiratory distress syndrome and its receptor mechanism].
OBJECTIVE
To study the change in glucocorticoid receptor (GR) and cortisol, for the purpose of proposing a rational use of glucocorticoid (GC) in patients with acute respiratory distress syndrome (ARDS), and to evaluate its receptor mechanism.


METHODS
ARDS patients in general ICU were enrolled for the study. GR of peripheral leukocytes in the patients were determined by radioligand binding assay using((3)H) dexamethasone as ligand. ARDS patients were stratified into three groups, i.e. mild, moderate and severe by clinical indices. The dosage of GC in the treatment of ARDS varied according to the level of GR and clinical indices.


RESULTS
The proposed usage of GC according to the levels of GR, cortisol and clinical indices in the treatment of ARDS was shown to be rational.


CONCLUSIONS
The therapeutic effect of individualized dosage of GC may be much better in the treatment of ARDS.
Ma
Jun
J
Transplantation Center, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
D005938:Glucocorticoids / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D011965:Receptors, Glucocorticoid / Q000032:analysis / Q000502:physiology*; D012128:Respiratory Distress Syndrome / Q000188:drug therapy* / Q000378:metabolism
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid