Tolerance of granulocyte donors towards granulocyte colony-stimulating factor stimulation and of patients towards granulocyte transfusions: results of a multicentre study.
Data of 507 granulocyte donations from 183 donors were evaluated. No severe granulocyte colony-stimulating factor (G-CSF)-related side-effects were observed. Three donors complained of severe itching following infusion of hydroxyethyl starch (HES). A high proportion (85%) of the donors stated that they would donate granulocytes again. The mean granulocyte yield was 4.3 x 10(10). High-molecular-weight HES resulted in a significantly higher yield compared with low-molecular-weight HES. Mild, but no severe, adverse transfusion reactions were observed in 16% of the recipients. A leucocyte alloimmunization rate of 24% was found. G-CSF stimulation and transfusion of G-CSF-mobilized granulocytes were well tolerated by donors and recipients, respectively.
Bux
J
J
Department of Transfusion Medicine, University of Giessen, Giessen, Germany. Juergen.Bux@immunologie.med.uni-giessen.de
Cassens
U
U
Dielschneider
T
T
Duchscherer
M
M
Edel
E
E
Eichler
H
H
Haas
C
C
Moog
R
R
Peschke
H
H
Peters
C
C
Ryzenkov
I
I
Schlenke
P
P
Ullrich
H
H
Wiesneth
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001782:Blood Donors; D003601:Cytotoxicity Tests, Immunologic; D004244:Dizziness / Q000139:chemically induced; D003875:Drug Eruptions / Q000209:etiology; D005221:Fatigue / Q000139:chemically induced; D005260:Female; D005334:Fever / Q000209:etiology; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects* / Q000494:pharmacology; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007937:Leukapheresis; D007958:Leukocyte Count; D017708:Leukocyte Transfusion / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim