title: Interleukin 1 beta enhances conditioned fear memory in rats: possible involvement of glucocorticoids.
abstract: Central administration of 15 ng interleukin (IL)-1beta in the rat significantly enhanced conditioned fear memory assessed by a passive avoidance task, when retested at 24 and 48 h post-training. Pain threshold was unaffected by 15 ng IL-1beta administration. IL-1beta treatment also increased serum corticosterone. This increase in serum corticosterone was further enhanced in rats given both IL-1beta and footshock. Furthermore, the glucocorticoid receptor antagonist mifepristone blocked IL-1beta-induced elevation in corticosterone and also attenuated the enhanced conditioned fear memory. Central administration of IL-1beta significantly increased prostaglandin E2 and decreased the anti-inflammatory cytokine IL-10 release from whole blood cultures; therefore this treatment appears to be effective in inducing an inflammatory response in both the periphery and the brain. The present study confirms that IL-1beta can enhance conditioned fear memory, an effect which is correlated with changes in glucocorticoid function. This facilitation of defensive behaviour could reflect adaptive responses which may enhance survival during sickness.
authors: Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, Canada, V6T 2A1. caisong@interchange.ubc.ca
authors: Cai
authors: C
authors: Song
authors: Anthony G
authors: AG
authors: Phillips
authors: Brian
authors: B
authors: Leonard
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects*; D003345:Corticosterone / Q000097:blood*; D015232:Dinoprostone / Q000378:metabolism; D004347:Drug Interactions; D004597:Electroshock / Q000379:methods; D005239:Fear / Q000187:drug effects*; D006727:Hormone Antagonists / Q000494:pharmacology; D007276:Injections, Intraventricular / Q000379:methods; D007375:Interleukin-1 / Q000494:pharmacology*; D016753:Interleukin-10 / Q000378:metabolism; D008297:Male; D015735:Mifepristone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
chemical_list: D006727:Hormone Antagonists; D007375:Interleukin-1; D016753:Interleukin-10; D015735:Mifepristone; D015232:Dinoprostone; D003345:Corticosterone