title: Endophilin and synaptojanin hook up to promote synaptic vesicle endocytosis.
abstract: Clathrin-mediated endocytosis of synaptic vesicles requires molecular rearrangements of proteins as well as lipids. In this issue of Neuron, Schuske et al. and Verstreken et al. show that the lipid-modifying enzyme endophilin recruits and stabilizes the polyphosphoinositide phosphatase synaptojanin at nerve terminals. This remarkable pairing of two enzymatic activities promotes multiple steps of clathrin-mediated endocytosis of synaptic vesicles.
authors: Neuroscience Graduate Program, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors: Wei
authors: W
authors: Song
authors: Konrad E
authors: KE
authors: Zinsmaier
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002966:Clathrin / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D006801:Humans; D009154:Mutation / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D017729:Presynaptic Terminals / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology; D013572:Synaptic Vesicles / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D002966:Clathrin; D009419:Nerve Tissue Proteins; C107640:SH3GL2 protein, human; C097702:synaptojanin; D010744:Phosphoric Monoester Hydrolases