title: Treatment of grade III anal intraepithelial neoplasia with photodynamic therapy: report of a case.
abstract: OBJECTIVE
  We report the use of photodynamic therapy to treat a 53-year-old female with Grade III anal intraepithelial neoplasia.
  
  
  METHODS
  Topical 5-aminolevulinic acid cream was applied to the affected area five hours before light treatment. The distribution of 5-aminolevulinic acid-induced protoporphyrin IX was identified by its characteristic red fluorescence. The lesion was treated by illumination with a 630-nm red laser light that used a total energy of 125 J/cm2 for approximately 17 minutes.
  
  
  RESULTS
  Complete symptomatic relief was achieved after the first photodynamic therapy session, and macroscopic and microscopic ablation of dysplasia was achieved after a second session of photodynamic therapy. Healing was excellent, with no residual scarring or functional loss.
  
  
  CONCLUSIONS
  Photodynamic therapy offers a simple, noninvasive method for treatment of anal intraepithelial neoplasia.
authors: Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, Dundee, United Kingdom.
authors: Khaled A
authors: KA
authors: Hamdan
authors: Iain S
authors: IS
authors: Tait
authors: Valerie
authors: V
authors: Nadeau
authors: Miles
authors: M
authors: Padgett
authors: Frank
authors: F
authors: Carey
authors: Robert J
authors: RJ
authors: Steele
mesh_terms: D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002278:Carcinoma in Situ / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid