Tinzaparin: considerations for use in clinical practice.
OBJECTIVE
To evaluate the safety and effectiveness of tinzaparin for the prevention and treatment of venous thromboembolism (VTE).


METHODS
A MEDLINE and PubMed database search (1980-December 2002) was conducted. Only articles written in English were reviewed.


METHODS
Articles reporting the safety, efficacy, and cost-effectiveness of tinzaparin in humans were evaluated. Emphasis was placed on randomized, controlled trials.


RESULTS
Tinzaparin sodium is a low-molecular-weight heparin (LMWH) that exerts its anticoagulant effect through inhibition of factors Xa and IIa and release of tissue factor pathway inhibitor from the vascular epithelium. Tinzaparin is indicated for treatment of acute symptomatic deep-vein thrombosis (DVT), with or without pulmonary embolism. Clinical studies suggest that tinzaparin is also effective for VTE prophylaxis, as well as other indications. Once-daily subcutaneous tinzaparin is equally or more effective than intravenous unfractionated heparin (UFH) for prevention and treatment of VTE, at least as safe as UFH for bleeding complications, and requires little or no monitoring. No dose "cap" is required for obese patients, and no initial dosing adjustments are necessary in elderly and/or renally impaired patients, although some monitoring is recommended. The few comparative data available suggest that tinzaparin efficacy may be comparable to that of other LMWHs; more comparative studies are needed. Pharmacoeconomic studies indicate a favorable cost-benefit ratio.


CONCLUSIONS
Tinzaparin is safe and effective for prevention and treatment of DVT. Consistent once-daily dosing may facilitate self-administration of tinzaparin in the outpatient setting.
Nutescu
Edith A
EA
Department of Pharmacy Practice, College of Pharmacy, The University of Illinois at Chicago, Chicago, IL, USA. enutescu@uic.edu
Shapiro
Nancy L
NL
Feinstein
Helen
H
Rivers
Christina W
CW
D000818:Animals; D002986:Clinical Trials as Topic / Q000191:economics / Q000379:methods / Q000706:statistics & numerical data*; D006495:Heparin, Low-Molecular-Weight / Q000191:economics / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans; D000078222:Tinzaparin; D020246:Venous Thrombosis / Q000188:drug therapy* / Q000191:economics / Q000378:metabolism
D006495:Heparin, Low-Molecular-Weight; D000078222:Tinzaparin