[Two advanced gastric cancer patients who showed malignant ileus soon after administration of combination therapy of preoperative intra-peritoneal chemotherapy and gastrectomy].
Forty-eight patients with serosa-invaded advanced gastric cancer were administered to pre-operative intra-peritoneal chemotherapy to prevent peritoneal recurrence. There were no severe adverse effects from the intra-peritoneal chemotherapy. Of these patients, 2 showed malignant ileus shortly after intra-peritoneal chemotherapy and gastrectomy, and needed laparotomy because of dilatation of duodenum stump and liver dysfunction. The intestines and mesothelium showed diffuse thickness and hardness. We report the clinicopathological features of these cases and therapeutic limitation of intra-peritoneal chemotherapy.
Fujiwara
Yoshiyuki
Y
Dept. of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University.
Taniguchi
Hirokazu
H
Kimura
Yutaka
Y
Takiguchi
Shuji
S
Yasuda
Takushi
T
Yano
Masahiko
M
Monden
Morito
M
D002293:Adenocarcinoma, Scirrhous / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D005743:Gastrectomy; D006801:Humans; D045823:Ileus / Q000209:etiology*; D007274:Injections, Intraperitoneal / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage / Q000009:adverse effects; D009361:Neoplasm Invasiveness; D011300:Preoperative Care; D013274:Stomach Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
D016685:Mitomycin; D002945:Cisplatin