Sialylated endogenous glycoconjugates in plant cells.
Bioengineered plants are emerging as promising systems for the production of therapeutically valuable proteins. It has been commonly accepted that plants do not perform mammalian-like post-translational modifications, particularly sialylation of glycoconjugates, and no evidence has previously been reported to suggest that they have such capabilities. Here we report the presence of sialylated glycoconjugates in suspension-cultured cells of Arabidopsis thaliana and suggest that a genetic and enzymatic basis for sialylation exists in plants.
Shah
Miti M
MM
Harrington Department of Bioengineering and Arizona BioDesign Institute, Arizona State University, PO Box 879709, Tempe, Arizona 85287-9709, USA.
Fujiyama
Kazuhito
K
Flynn
C Robert
CR
Joshi
Lokesh
L
D017360:Arabidopsis / Q000378:metabolism*; D001212:Asialoglycoproteins / Q000032:analysis* / Q000378:metabolism*; D006001:Glycoconjugates / Q000032:analysis* / Q000378:metabolism*; D006031:Glycosylation; D019158:N-Acetylneuraminic Acid / Q000032:analysis* / Q000378:metabolism*
D001212:Asialoglycoproteins; D006001:Glycoconjugates; D019158:N-Acetylneuraminic Acid