title: Monitoring renal oxygen supply in critically-ill patients using urinary oxygen tension.
abstract: Critically-ill patients are at risk of developing renal disorders as a consequence of systemic hypoperfusion. Ischemic acute tubular necrosis and resulting acute renal failure are caused by hypotension or therapeutic management. In this study, we tested the change of O(2) availability induced by fenoldopam mesylate using the continuous measurement of urinary oxygen tension (PuO(2)), a relatively noninvasive technique that could provide potentially important real-time data regarding renal oxygenation in intensive care unit patients. Fenoldopam was administered at different doses (0.03, 0.06, and 0.09 microg x kg(-1) x min(-1)) to 50 stable critically-ill patients. Urine output was collected every hour to assess volume and urinary electrolytes. Heart rate, mean arterial blood pressure, cardiac output, pulmonary artery occlusion pressure, arterial oxygen delivery index, and oxygen consumption index were analyzed after fenoldopam dose modifications and at infusion end. PaO(2) and PuO(2) continuous measurements were obtained through two sensors inserted in the radial artery and in the bladder. After a fenoldopam dose increase, PuO(2) significantly increased (P < 0.05), whereas PaO(2) remained unchanged. During the study, heart rate, mean arterial blood pressure, cardiac output, central venous pressure, pulmonary artery occlusion pressure, arterial oxygen delivery index, and oxygen consumption remained unchanged. Dose-dependent PuO(2) increases, unrelated to indexes of systemic perfusion and cardiac function, demonstrate that fenoldopam affects the balance between renal oxygen supply and demand in stable critically-ill patients.
  
  
  CONCLUSIONS
  Acute renal failure in critically-ill patients is associated with frequent mortality. Prolonged renal hypoperfusion cannot be detected by current systemic hemodynamic indexes. Using continuous measurement of urinary oxygen tension, which could indirectly provide real-time data regarding renal oxygenation, our study showed that fenoldopam increases the ratio between oxygen supply and demand.
authors: *Department of Anesthesiology and Intensive Care, University of Rome "La Sapienza"; and †Department of Anesthesiology and Intensive Care, Catholic University of Rome, Italy.
authors: Andrea
authors: A
authors: Morelli
authors: Monica
authors: M
authors: Rocco
authors: Giorgio
authors: G
authors: Conti
authors: Alessandra
authors: A
authors: Orecchioni
authors: Roberto
authors: R
authors: Alberto De Blasi
authors: Flaminia
authors: F
authors: Coluzzi
authors: Paolo
authors: P
authors: Pietropaoli
mesh_terms: D000293:Adolescent; D001806:Blood Urea Nitrogen; D002648:Child; D003404:Creatinine / Q000097:blood; D016638:Critical Illness; D004231:Diuresis / Q000187:drug effects; D018491:Dopamine Agonists / Q000494:pharmacology; D004567:Electrodes, Implanted; D005260:Female; D018818:Fenoldopam / Q000494:pharmacology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008991:Monitoring, Physiologic; D009318:Natriuresis / Q000187:drug effects; D010100:Oxygen / Q000652:urine*; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000652:urine; D001743:Urinary Bladder / Q000502:physiology; D014563:Urodynamics / Q000502:physiology
chemical_list: D018491:Dopamine Agonists; D003404:Creatinine; D018818:Fenoldopam; D011188:Potassium; D010100:Oxygen