Massive hyperplasia of marginal zone B-cells with clear cytoplasm in the lymph node: a case report.
An enlarged axillary lymph node from a 63-year-old woman showed proliferating marginal zone B-cells arranged in a vague nodular pattern or in band-forming aggregates throughout the cortex. Marginal zone B-cells, which also infiltrated the adjacent fatty tissue, had round or slightly indented nuclei of medium size and a moderate amount of clear cytoplasm. Immunohistochemically, these cells were CD20+, CD79a+, Bcl-2+, sIgD-, CD5-, CD10-, CD21-, CD23-, CD45RO-, Bcl-6-, and cyclin D-. A portion of the cells were sIgM- and CD43-positive. The polytypic nature of these cells was demonstrated by immunohistochemistry and polymerase chain reaction. Systemic bacterial infection appears to be the cause of marginal zone B-cell hyperplasia. This unusual marginal zone B-cell hyperplasia should be differentiated from low-grade B cell lymphomas, and particularly from nodal marginal zone B-cell lymphomas.
Kojima
Masaru
M
Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ohta, Japan. mkojima@gunma-cc.jp
Nakamura
Shigeo
S
Tanaka
Hiroshi
H
Yamane
Yuko
Y
Sugihara
Shiro
S
Masawa
Nobuhide
N
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015703:Antigens, CD / Q000378:metabolism; D001365:Axilla; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology*; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D003593:Cytoplasm / Q000473:pathology; D004247:DNA / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D017403:In Situ Hybridization; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology*; D016393:Lymphoma, B-Cell / Q000175:diagnosis; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011239:Prednisolone / Q000627:therapeutic use; D019310:Pseudolymphoma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*
D000900:Anti-Bacterial Agents; D015703:Antigens, CD; D015415:Biomarkers; D004247:DNA; D011239:Prednisolone