When to initiate HIV therapy: a control theoretic approach.
This paper shows an application of control theory to human immunodeficiency virus (HIV)/AIDS models. Minimum singular value decomposition is applied to HIV/AIDS models to measure the extent to which the different stages in the progression of HIV/AIDS disease are controllable and, consequently, when best to initiate therapy such that the general objectives of therapy are satisfied. Simulations will be used to demonstrate the effect of treatment at various stages. Comparisons will be made between mono-class and combination therapies and between when therapy is initiated at the acute infection, asymptomatic and the advanced stages.
Jeffrey
Annah M
AM
Department of Electrical, Electronic, and Computer Engineering Engineering, University of Pretoria, Pretoria 0002, South Africa. mjeffrey@tuks.co.za
Xia
Xiaohua
X
Craig
Ian K
IK
D044966:Anti-Retroviral Agents / Q000008:administration & dosage*; D003198:Computer Simulation; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D006678:HIV / Q000187:drug effects* / Q000276:immunology; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008954:Models, Biological; D011157:Population Dynamics; D013598:Systems Theory; D019562:Viral Load / Q000379:methods*
D044966:Anti-Retroviral Agents