Isolated IgA deficiency after chemotherapy for acute myelogenous leukemia in an infant.
IgA deficiency is a relatively common congenital immunodeficiency in children. It can either be asymptomatic or lead to frequent infections, most often of the sinuses and lungs. Intensive chemotherapy for acute leukemia is also profoundly immunosuppressive and can be complicated with life-threatening infections, usually associated with neutropenia and prolonged lymphopenia in the post-bone marrow transplant setting. Isolated, acquired immunoglobulin deficiency that occurs during treatment has been described but is usually transient. In this report, the authors describe a patient with infant acute myelogenous leukemia with acquired, persistent IgA deficiency.
Uram
Rebecca
R
Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Box 2916, Durham, NC 27710, USA.
Rosoff
Philip M
PM
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D003630:Daunorubicin / Q000008:administration & dosage / Q000009:adverse effects; D003907:Dexamethasone / Q000008:administration & dosage / Q000009:adverse effects; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D017098:IgA Deficiency / Q000139:chemically induced* / Q000628:therapy; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007223:Infant; D007948:Leukemia, Monocytic, Acute / Q000150:complications* / Q000188:drug therapy; D008297:Male; D013866:Thioguanine / Q000008:administration & dosage / Q000009:adverse effects
D016756:Immunoglobulins, Intravenous; D003561:Cytarabine; D005047:Etoposide; D003907:Dexamethasone; D013866:Thioguanine; D003630:Daunorubicin