title: Synthesis of styrylbenzofuran derivatives as styrylquinoline analogues for HIV-1 integrase inhibitor.
abstract: A series of styrylbenzofuran derivatives (8a-i) as styrylquinoline isosters were efficiently prepared by Wittig reaction and evaluated for inhibitory activity against HIV-1 integrase. In this series, compounds 8g, 8h and 8i containing a free catechol ring showed moderate inhibitory activities (IC50= approximately 40 microM) against HIV-1 integrase, while less than the corresponding styrylquinoline compound (I).
authors: Medicinal Chemistry Research Center, Life Sciences Division, Korea Institute of Science & Technology, P.O. Box 131 Cheongryang, Seoul 130-650, South Korea.
authors: Ho
authors: H
authors: Yoo
authors: Jae Yeol
authors: JY
authors: Lee
authors: Jang Hyun
authors: JH
authors: Park
authors: Bong Young
authors: BY
authors: Chung
authors: Yong Sup
authors: YS
authors: Lee
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000494:pharmacology; D019427:HIV Integrase / Q000378:metabolism*; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D001572:Benzofurans; D019428:HIV Integrase Inhibitors; D011804:Quinolines; C481600:styrylquinoline; D019427:HIV Integrase