title: Nonspecific interstitial pneumonia in collagen vascular diseases: comparison of the clinical characteristics and prognostic significance with usual interstitial pneumonia.
abstract: BACKGROUND
  Nonspecific interstitial pneumonia (NSIP) has recently been described as a distinct clinicopathological entity among idiopathic interstitial pneumonias (IIP), having more favorable prognosis than usual interstitial pneumonia (UIP). Although NSIP was initially reported to also occur in patients with interstitial pneumonia associated with collagen vascular diseases (IP-CVD), the prevalence of NSIP and its prognostic significance in IP-CVD remains to be determined. Thus, we attempted to clarify clinical characteristics and prognostic significance of NSIP in IP-CVD.
  
  
  METHODS
  We histologically examined surgical lung biopsies from 43 patients with IP-CVD based on a current classification of interstitial pneumonias, and compared the clinical characteristics and prognostic significance of NSIP with UIP in IP-CVD. We also studied 98 patients with biopsy-proven NSIP and UIP in IIP, and compared the prognostic significance of histopathologic subclassification in IIP with that in IP-CVD.
  
  
  RESULTS
  In IP-CVD, twenty-six patients (60%) were classified as NSIP, 17 (40%) as UIP. In contrast, 76 (77%) were categorized into UIP and 22 (23%) into NSIP of the patients with IIP. No significant difference in survival rates was observed between UIP and NSIP in IP-CVD (p = 0.3863), while, in IIP, NSIP has a significant better survival than UIP (p = 0.022).
  
  
  CONCLUSIONS
  These results suggest that NSIP is more common histologic pattern than UIP in IP-CVD and, unlike in IIP, the prognosis of NSIP patients may not be different from that of UIP patients in IP-CVD.
authors: Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
authors: Yutaro
authors: Y
authors: Nakamura
authors: Kingo
authors: K
authors: Chida
authors: Takafimi
authors: T
authors: Suda
authors: Hiroshi
authors: H
authors: Hayakawa
authors: Masatoshi
authors: M
authors: Iwata
authors: Shiro
authors: S
authors: Imokawa
authors: Tomoyoshi
authors: T
authors: Tsuchiya
authors: Masaaki
authors: M
authors: Ida
authors: Hitoshi
authors: H
authors: Gemma
authors: Kazumasa
authors: K
authors: Yasuda
authors: Takeshi
authors: T
authors: Yagi
authors: Toshihiro
authors: T
authors: Shirai
authors: Ryoji
authors: R
authors: Tamura
authors: Yutaka
authors: Y
authors: Nakano
authors: Takeo
authors: T
authors: Hirata
authors: Hirotoshi
authors: H
authors: Nakamura
authors: Thomas V
authors: TV
authors: Colby
mesh_terms: D000368:Aged; D001706:Biopsy; D003240:Connective Tissue Diseases / Q000150:complications*; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000209:etiology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis