Programmed cell death protein 4 (pdcd4): a novel target for antineoplastic therapy?
Pdcd4 is a novel gene first identified as a differentially expressed protein during apoptosis. In the meantime not only the impact of Pdcd4 in programmed cell death but also an implication in transformation suppression by inhibition of protein translation is discussed. These features implicate a potential value of Pdcd4 as a molecular target in cancer therapy. This review summarizes the current knowledge about expression, structure and function of Pdcd4.
Lankat-Buttgereit
Brigitte
B
Clinical Research Unit for Gastrointestinal Endocrinology, University of Marburg, 35037 Marburg, Germany. lankatbu@mailer.uni-marburg.de
Göke
Rüdiger
R
D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D039603:Eukaryotic Initiation Factor-4G / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000628:therapy; D016601:RNA-Binding Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics* / Q000502:physiology*; D015854:Up-Regulation
D051017:Apoptosis Regulatory Proteins; D039603:Eukaryotic Initiation Factor-4G; C498443:Pdcd4 protein, mouse; D016601:RNA-Binding Proteins; D025521:Tumor Suppressor Proteins