title: MRI and EEG findings in surgically treated patients with partial seizures due to neuronal migration disorders, their relations to each other and to surgery outcome.
abstract: OBJECTIVE
  To evaluate magnetic resonance imaging (MRI) and electro-encephalogram (EEG) findings of patients with therapy-resistant partial seizures due to neuronal migration disorders (NMD), and compare them with each other and with surgery outcome.
  
  
  METHODS
  The MRI, interictal and ictal EEG findings, and their relations to each other in 41 patients with NMD were compared with class IA surgery outcome.
  
  
  RESULTS
  The patients showed an MRI lesion in decreasing frequency from the frontal to the occipital areas. A predominantly extratemporal location of the interictal EEG foci (73.3%) and ictal patterns (82.4%) was therefore apparent, also showing a diminishing frequency from the anterior to the posterior areas. Comparing the EEG foci with the MRI lesions, the same location of the interictal foci was found in 68.4% and of the ictal foci in 52.7%, including several cases with a more widespread EEG focus or MRI lesion. The same location of interictal as well as ictal foci was evident in 85.7%. The most favourable surgery outcome (class IA) was, on average, apparent in patients with an MRI lesion (28.6% vs 25%), a main interictal EEG focus (50% vs 18%) and an ictal seizure pattern (37.5% vs 16.7%) located in the temporal area; likewise, if the interictal focus (30.8% vs 18.2%) and the ictal pattern (31.8% vs 12.5%) showed the same location as the MRI lesion, as well as when the interictal and ictal EEG changes had an equal location (30% vs 20%).
  
  
  CONCLUSIONS
  MRI and EEG recordings show relatively close relations to each other and might be important methods to predict surgery outcome in NMD patients.
authors: Telgter Str. 42, 33619 Bielefeld, Germany. angela.ploeger@t-online.de
authors: R
authors: R
authors: Degen
authors: A
authors: A
authors: Ebner
authors: R
authors: R
authors: Lahl
authors: St
authors: S
authors: Bartling
authors: H W
authors: HW
authors: Pannek
authors: I
authors: I
authors: Tuxhorn
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002465:Cell Movement; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D020938:Epilepsy, Partial, Motor / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009474:Neurons / Q000502:physiology*; D012189:Retrospective Studies; D016896:Treatment Outcome