Successful use of 111In-pentetrotide scintigraphy for localizing ectopic adrenocorticotropin-producing bronchial carcinoid tumor in a patient with Cushing's syndrome.
A 34-year-old man was diagnosed with clinical Cushing's syndrome based on circadian fluctuation of plasma adrenocorticotropin and serum cortisol levels and Liddle's-method. The presence of ectopic adrenocorticotropin production was suspected. Urine 5-hydroxyindoleaceturic acid level was high. Chest computed-tomography scan revealed a mass in the right upper lung. 111In-pentetrotide scintigraphy demonstrated marked accumulation in the right upper lung. We suspected an adrenocorticotropin-producing bronchial carcinoid. Plasma adrenocorticotropin and serum cortisol levels decreased immediately following resection of the tumor. Adrenocorticotropin production by tumor cells was confirmed by immunohistochemistry. This case indicates 111In-pentetrotide scintigraphy could be successfully used to identify and localize ectopic adrenocorticotropin-producing bronchial carcinoid.
Kishida
Ken
K
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka.
Moriwaki
Makoto
M
Miyagawa
Jun-ichiro
J
Okita
Kohei
K
Kondo
Takashi
T
Itoh
Kimiko
K
Umemura
Satoshi
S
Kozawa
Junji
J
Iwahashi
Hiromi
H
Yoshizumi
Tohru
T
Imagawa
Akihisa
A
Yamagata
Kazuya
K
Maruyama
Takao
T
Toyoshima
Hiroyuki
H
Kurokawa
Eiji
E
Funahashi
Tohru
T
Matsuzawa
Yuji
Y
D000182:ACTH Syndrome, Ectopic / Q000000981:diagnostic imaging / Q000209:etiology*; D000328:Adult; D001984:Bronchial Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D002276:Carcinoid Tumor / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D003480:Cushing Syndrome / Q000209:etiology*; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D011877:Radionuclide Imaging; D013004:Somatostatin / Q000031:analogs & derivatives*
D007205:Indium Radioisotopes; D013004:Somatostatin; C081788:pentetreotide