Recent developments in ring opening polymerization of lactones for biomedical applications.
Aliphatic polyesters prepared by ring-opening polymerization of lactones are now used worldwide as bioresorbable devices in surgery (orthopaedic devices, sutures, stents, tissue engineering, and adhesion barriers) and in pharmacology (control drug delivery). This review presents the various methods of the synthesis of polyesters and tailoring the properties by proper control of molecular weight, composition, and architecture so as to meet the stringent requirements of devices in the medical field. The effect of structure on properties and degradation has been discussed. The applications of these polymers in the biomedical field are described in detail.
Albertsson
Ann-Christine
AC
Department of Fibre and Polymer Technology, The Royal Institute of Technology, S-10044 Stockholm, Sweden.
Varma
Indra K
IK
D020341:Absorbable Implants; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D001673:Biodegradation, Environmental; D002384:Catalysis; D007783:Lactones / Q000737:chemistry* / Q000627:therapeutic use; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use
D001672:Biocompatible Materials; D007783:Lactones; D011091:Polyesters