title: Presumed Angel's trumpet (Brugmansia) poisoning: clinical effects and epidemiology.
abstract: OBJECTIVE
  To investigate the pattern and epidemiology of anticholinergic plant poisoning, and to characterize its time course and clinical features.
  
  
  METHODS
  We reviewed all anticholinergic plant poisonings using a prospective database of all poisonings admitted to a major toxicology unit in Australia. All patients that presented with anticholinergic plant poisoning between July 1990 and June 2000 were included. Patient demographics, details of poisoning, diagnostic clinical features, adverse effects (seizures, arrhythmias, hypotension, accidental injury), and treatments required were obtained. Important diagnostic features were analysed and compared to previous studies.
  
  
  RESULTS
  Thirty-three patients were presumed to have ingested Brugmansia spp. (Angel's trumpet) based on their description of the plant; median age 18 years (interquartile range 16-20); 82% males. Thirty-one ingested a brewed tea or parts of the plant (flower). Thirty-one used it recreationally. Common clinical features were: mydriasis (100%), mean duration 29 h (SD 13) and delirium (88%) with a mean duration of 18 h (SD 12). Tachycardia only occurred in 11 of the 33 patients (33%). In 24 patients where the time of ingestion was certain, 7 of 8 (88%) patients presenting within 5 h had tachycardia and only 5 out of 16 (31%) presenting after 5 h had tachycardia. There were no deaths, seizures or arrhythmias (excepting tachycardia). One patient had hypotension and two sustained accidental traumatic injuries. Nineteen patients required sedation, mainly with benzodiazepines. Physostigmine was used diagnostically in eight cases.
  
  
  CONCLUSIONS
  Anticholinergic plant abuse is sporadic in nature. Most cases were moderate in severity, requiring sedation only, and severe toxicity was rare. Mydriasis and delirium were the commonest features, the later having important implications for management.
authors: Discipline of Clinical Pharmacology, University of Newcastle, Department of Clinical Toxicology and Pharmacology, Newcastle Mater Misericordiae Hospital, Newcastle, New South Wales, Australia. gsbite@bigpond.com
authors: Geoffrey K
authors: GK
authors: Isbister
authors: Patrick
authors: P
authors: Oakley
authors: Andrew H
authors: AH
authors: Dawson
authors: Ian M
authors: IM
authors: Whyte
mesh_terms: D000293:Adolescent; D000328:Adult; D001315:Australia / Q000453:epidemiology; D018680:Cholinergic Antagonists / Q000506:poisoning; D004630:Emergencies; D005260:Female; D006801:Humans; D008297:Male; D018514:Plant Structures / Q000506:poisoning; D011041:Poisoning / Q000453:epidemiology / Q000503:physiopathology; D011446:Prospective Studies; D019657:Solanaceae / Q000506:poisoning*
chemical_list: D018680:Cholinergic Antagonists