title: Corpus callosum abnormalities in psychopathic antisocial individuals.
abstract: BACKGROUND
  Psychopathic antisocial individuals have previously been characterized by abnormal interhemispheric processing and callosal functioning, but there have been no studies on the structural characteristics of the corpus callosum in this group.
  
  
  OBJECTIVE
  To assess whether (1) psychopathic individuals with antisocial personality disorder show structural and functional impairments in the corpus callosum, (2) group differences are mirrored by correlations between dimensional measures of callosal structure and psychopathy, (3) callosal abnormalities are associated with affective deficits, and (4) callosal abnormalities are independent of psychosocial deficits.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Community sample.
  
  
  METHODS
  Fifteen men with antisocial personality disorder and high psychopathy scores and 25 matched controls, all from a larger sample of 83 community volunteers.
  
  
  METHODS
  Structural magnetic resonance imaging measures of the corpus callosum (volume estimate of callosal white matter, thickness, length, and genu and splenium area), functional callosal measures (2 divided visual field tasks), electrodermal and cardiovascular activity during a social stressor, personality measures of affective and interpersonal deficits, and verbal and spatial ability.
  
  
  RESULTS
  Psychopathic antisocial individuals compared with controls showed a 22.6% increase in estimated callosal white matter volume (P<.001), a 6.9% increase in callosal length (P =.002), a 15.3% reduction in callosal thickness (P =.04), and increased functional interhemispheric connectivity (P =.02). Correlational analyses in the larger unselected sample confirmed the association between antisocial personality and callosal structural abnormalities. Larger callosal volumes were associated with affective and interpersonal deficits, low autonomic stress reactivity, and low spatial ability. Callosal abnormalities were independent of psychosocial deficits.
  
  
  CONCLUSIONS
  Corpus callosum abnormalities in psychopathic antisocial individuals may reflect atypical neurodevelopmental processes involving an arrest of early axonal pruning or increased white matter myelination. These findings may help explain affective deficits and previous findings of abnormal interhemispheric transfer in psychopathic individuals.
authors: Department of Psychology, University of Southern California, Los Angeles, CA 90089-1061, USA. raine@usc.edu
authors: Adrian
authors: A
authors: Raine
authors: Todd
authors: T
authors: Lencz
authors: Kristen
authors: K
authors: Taylor
authors: Joseph B
authors: JB
authors: Hellige
authors: Susan
authors: S
authors: Bihrle
authors: Lori
authors: L
authors: Lacasse
authors: Mimi
authors: M
authors: Lee
authors: Sharon
authors: S
authors: Ishikawa
authors: Patrick
authors: P
authors: Colletti
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology; D061085:Agenesis of Corpus Callosum; D000987:Antisocial Personality Disorder / Q000175:diagnosis* / Q000523:psychology; D001143:Arousal / Q000502:physiology; D016022:Case-Control Studies; D003337:Corpus Callosum / Q000473:pathology; D004292:Dominance, Cerebral / Q000502:physiology; D006801:Humans; D007089:Image Enhancement; D007090:Image Interpretation, Computer-Assisted; D007398:Interpersonal Relations; D008279:Magnetic Resonance Imaging; D008297:Male; D008432:Mathematical Computing; D010552:Personality Assessment; D014888:Wechsler Scales