H-NS in Gram-negative bacteria: a family of multifaceted proteins.
DNA-packaging and the control of gene expression constitute a major challenge for bacteria to survive and adapt to environmental changes. The use of multiple strategies to solve these problems could explain the presence of various nucleoid-associated proteins in bacteria. H-NS, one of these proteins, has been extensively studied in Escherichia coli, and a variety of phenotypes have been associated with a mutation in its structural gene. However, the role of H-NS in bacterial physiology and its mechanism of action are still a matter of debate. The expanding number of H-NS-related proteins identified in Gram-negative bacteria reveals interesting clues about their structure-function-evolution relationship.
Tendeng
Christian
C
MRC Centre for Dev. Neurobiology, New Hunt's House, Guy's Campus, London, SE1 9RT, UK.
Bertin
Philippe N
PN
D001426:Bacterial Proteins / Q000235:genetics* / Q000302:isolation & purification / Q000502:physiology; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification / Q000502:physiology; D019143:Evolution, Molecular; D005544:Forecasting; D006090:Gram-Negative Bacteria / Q000235:genetics* / Q000502:physiology
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C031908:H-NS protein, bacteria