Chemotherapy-induced secondary malignancies.
Changes in chemotherapy protocols have influenced the risk and rate of secondary malignancies in high-risk populations. The alkylating agents, topoisomerase inhibitors, and anthracycline agents pose the highest risk of initiating carcinogenesis. Normal cells that are especially sensitive to chemotherapy and most likely to begin carcinogenesis include those of the bone marrow, hair follicles, and the epithelial cells of the gastrointestinal tract. Thus, the development of secondary hematologic cancers such as leukemia and lymphoma pose the greatest risk to adult and childhood cancer survivors. Lifelong surveillance is recommended.
Vega-Stromberg
Teri
T
St. Joseph Regional Medical Center, Nursing Office, Milwaukee, WI 53210, USA. tstrombe@covhealth.org
D000359:Aftercare / Q000379:methods; D018943:Anthracyclines / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000009:adverse effects*; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects; D003043:Cocarcinogenesis; D004250:DNA Topoisomerases, Type II / Q000187:drug effects; D005190:Family / Q000523:psychology; D006801:Humans; D007255:Information Services; D016609:Neoplasms, Second Primary / Q000139:chemically induced* / Q000451:nursing; D024802:Nurse's Role; D009859:Oncology Nursing / Q000379:methods; D010353:Patient Education as Topic / Q000379:methods; D012307:Risk Factors; D017741:Survivors; D059005:Topoisomerase II Inhibitors
D018943:Anthracyclines; D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D059005:Topoisomerase II Inhibitors; D004250:DNA Topoisomerases, Type II