title: Investigation of SEN virus infection in patients with cryptogenic acute liver failure, hepatitis-associated aplastic anemia, or acute and chronic non-A-E hepatitis.
abstract: SEN virus (SENV) has been tentatively linked to transfusion-associated non-A-E hepatitis. We investigated SENV's role in unexplained hepatitis in other settings. Polymerase chain reaction amplification was used to detect 2 SENV variants (SENV-D and SENV-H) in 1706 patients and control subjects. SENV was detected in 54 (22%) of 248 patients with acute or chronic non-A-E hepatitis, 9 (35%) of 26 patients with hepatitis-associated aplastic anemia, and 0 of 17 patients with cryptogenic acute liver failure, compared with 150 (24%) of 621 control subjects with liver disease and 76 (10%) of 794 healthy control subjects. When controlling for geographic region, the prevalence of SENV among case and control subjects was not significantly different. The severity of acute or chronic hepatitis A, B, or C was not influenced by coexisting SENV infection. No etiological role for SENV in the cause of cryptogenic hepatitis could be demonstrated.
authors: Department of Transfusion Medicine, Warren Grant Magnuson Clinical Center, National Heart, Lung, Blood Institute, National Institutes of Health, Bethesda, Maryland 20892-1184, USA.
authors: Takeji
authors: T
authors: Umemura
authors: Eiji
authors: E
authors: Tanaka
authors: George
authors: G
authors: Ostapowicz
authors: Kevin E
authors: KE
authors: Brown
authors: Stefan
authors: S
authors: Heringlake
authors: Nicolaos C
authors: NC
authors: Tassopoulos
authors: Richard Y-H
authors: RY
authors: Wang
authors: Anthony E T
authors: AE
authors: Yeo
authors: J Wai-Kuo
authors: JW
authors: Shih
authors: Koji
authors: K
authors: Orii
authors: Neal S
authors: NS
authors: Young
authors: Angelos
authors: A
authors: Hatzakis
authors: Michael P
authors: MP
authors: Manns
authors: William M
authors: WM
authors: Lee
authors: Kendo
authors: K
authors: Kiyosawa
authors: Harvey J
authors: HJ
authors: Alter
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000453:epidemiology / Q000821:virology*; D002648:Child; D018136:Circoviridae / Q000235:genetics / Q000254:growth & development*; D018173:Circoviridae Infections / Q000453:epidemiology / Q000821:virology*; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D005260:Female; D005858:Germany / Q000453:epidemiology; D006115:Greece / Q000453:epidemiology; D006518:Hepatitis Viruses / Q000254:growth & development; D006521:Hepatitis, Chronic / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D017114:Liver Failure, Acute / Q000453:epidemiology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D014481:United States / Q000453:epidemiology
chemical_list: D004279:DNA, Viral