[A research of endothelial cell-targeted therapy for cure of hypertrophic scar].
OBJECTIVE
To investigate the feasibility of endothelial cell-targeted therapy to cure post-burn hypertrophic scar.


METHODS
A hypertrophic scar animal model was made. Intralesional injecting of VEGF monoclonal antibody was performed for three weeks. The changes of scar in volume and morphology were observed.


RESULTS
1. The volume of scar decreased. 2. The number of the capillary, the amount of collagen I and collagen III decreased. 3. Transmission electron microscope examinations demonstrated many dead or apoptotic fibroblasts and endothelial cells. Fibrocytes were seen relatively common.


CONCLUSIONS
VEGF induces the growth and development of hypertrophic scar in that it induces excessive and uncontrollable angiogenesis, which favors excessive collagen synthesis. Endothelial cell-targeted therapy may be a promising method to cure post-burn hypertrophic scar.
Shen
Rui
R
Department of Burn, First Affiliated Hospital, Sun Yatsen University of Medical Sciences, Guangzhou 510080, China.
Li
Tian-zeng
TZ
Qi
Shao-hai
SH
Liang
Hui-zhen
HZ
Xu
Ying-bin
YB
Xie
Ju-lin
JL
Wu
Yi-fang
YF
Feng
Xiang-sheng
XS
Du
Yong-jun
YJ
D000818:Animals; D017209:Apoptosis; D002056:Burns / Q000150:complications*; D017439:Cicatrix, Hypertrophic / Q000139:chemically induced / Q000628:therapy*; D024042:Collagen Type I; D024061:Collagen Type III; D004195:Disease Models, Animal; D042783:Endothelial Cells; D005240:Feasibility Studies; D009389:Neovascularization, Pathologic / Q000209:etiology; D042461:Vascular Endothelial Growth Factor A
D024042:Collagen Type I; D024061:Collagen Type III; D042461:Vascular Endothelial Growth Factor A