Blockade of striatal 5-HT2 receptors produces retrograde amnesia in rats.
We have recently reported that intrastriatal administration of the serotonin (5-HT) releasing drug p-chloroamphetamine, and of 5-HT itself, produces a significant retention deficit of inhibitory avoidance. It is not known which of the 5-HT receptors are involved in the amnesic effect of serotonin. The present experiment was aimed at determining whether 5-HT2 receptors within the striatum are involved in memory consolidation. Ketanserine (0.5, 1.0, 2.0, or 4.0 ng) was infused bilaterally into the striatum of Wistar rats immediately after training of inhibitory avoidance, and retention of the task was measured 24 h later. A dose-dependent retention deficit was found. Together with the results from appropriate control groups, the results strongly suggest that striatal 5-HT2 receptors participate in memory consolidation of this aversive task.
Prado-Alcalá
Roberto A
RA
Instituto de Neurobiologi;a, Universidad Nacional Autónoma de México, PO Box 1-1141, Qro, Querétaro 76001, Mexico. prado@servidor.unam.mx
Solana-Figueroa
Rafael
R
Galindo
Luisa E
LE
Medina
Andrea C
AC
Quirarte
Gina L
GL
D000648:Amnesia, Retrograde / Q000139:chemically induced* / Q000523:psychology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000033:anatomy & histology; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004597:Electroshock; D007267:Injections; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D007650:Ketanserin