Negative regulation of cytokine signaling influences inflammation.
Inflammation is progressed by the action of pro-inflammatory cytokines, including IL-1, TNF, IFN-gamma and IL-6, and is resolved by anti-inflammatory cytokines, such as IL-4, IL-10, IL-13, IFN-alpha and transforming growth factor-beta (TGF-beta). Intracellular signal transduction pathways initiated by these cytokines have been studied extensively; these pathways ultimately activate transcription factors, such as NF-kappa B, Smad and STATs. Recently, negative feedback regulation of these pathways, mediated by molecules such as A-20, Smad7 and CIS/SOCS family proteins, has been identified. Negative regulation of cytokine signaling is quite important for inflammation.
Yoshimura
Akihiko
A
Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. yakihiko@bioreg.kyushu-u.ac.jp
Mori
Hiroyuki
H
Ohishi
Masanobu
M
Aki
Daisuke
D
Hanada
Toshikatsu
T
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D016207:Cytokines / Q000502:physiology*; D015536:Down-Regulation; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins; D012097:Repressor Proteins / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins
D002352:Carrier Proteins; D016207:Cytokines; D047908:Intracellular Signaling Peptides and Proteins; D012097:Repressor Proteins; C108944:SOCS1 protein, human; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins