Cholinesterase inhibitory activity of two farnesylacetone derivatives from the brown alga Sargassum sagamianum.
Two known farnesylacetone derivatives (1 and 2) were isolated from the Korean brown alga Sargassum sagamianum off Jeju Island, Korea. Compounds 1 and 2 were identified as (5E,10Z)-6,10,14-trimethylpentadeca-5,10-dien-2,12-dione and (5E,9E,13E)-6,10,4-trimethyl-pentadeca-5,9,13-trien-2,12-dione, respectively, by comparison with the literature data. Compounds 1 and 2 showed moderate acetylcholinesterase and butyrylcholinesterase inhibitory activities with IC50 values of 65.0 approximately 48.0 and 34.0 approximately 23.0 microM, respectively.
Ryu
Geonseek
G
Regional Research Center, Department of Chemical Technology, Hanbat National University, 16-1 Dukmyung-dong, Yusung-gu, Daejon 305-719, Korea.
Park
Soo Hee
SH
Kim
Eun Sook
ES
Choi
Byoung Wook
BW
Ryu
Shi Yong
SY
Lee
Bong Ho
BH
D002091:Butyrylcholinesterase / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D007536:Isomerism; D007659:Ketones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000459:Phaeophyceae / Q000737:chemistry*; D044647:Sargassum / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
C487422:6,10,14-trimethylpentadeca-5,10-dien-2,12-dione; C487423:6,10,14-trimethylpentadeca-5,9,13-trien-2,12-dione; D002800:Cholinesterase Inhibitors; D007659:Ketones; D013729:Terpenes; C014549:farnesylacetone; D002091:Butyrylcholinesterase