A2E, a byproduct of the visual cycle.
A substantial portion of the lipofuscin that accumulates with age and in some retinal disorders in retinal pigment epithelial (RPE) cells, forms as a consequence of light-related vitamin A recycling. Major constituents of RPE lipofuscin are the di-retinal conjugate A2E and its photoisomers. That the accretion of A2E has consequences for the cell, with the adverse effects of A2E being attributable to its amphiphilic structure and its photoreactivity, is consistent with evidence of an association between atrophic age-related macular degeneration (AMD) and excessive lipofuscin accumulation.
Sparrow
Janet R
JR
Department of Ophthalmology, Columbia University, 630 W. 168th Street, New York, NY 10032, USA. jrs88@columbia.edu
Fishkin
Nathan
N
Zhou
Jilin
J
Cai
Bolin
B
Jang
Young P
YP
Krane
Sonja
S
Itagaki
Yasuhiro
Y
Nakanishi
Koji
K
D001284:Atrophy / Q000378:metabolism; D006801:Humans; D008027:Light / Q000009:adverse effects; D008062:Lipofuscin / Q000378:metabolism*; D008268:Macular Degeneration / Q000378:metabolism*; D010857:Pigment Epithelium of Eye / Q000378:metabolism* / Q000528:radiation effects; D011726:Pyridinium Compounds / Q000378:metabolism*; D012160:Retina / Q000378:metabolism / Q000473:pathology*; D012172:Retinaldehyde / Q000378:metabolism; D012176:Retinoids / Q000378:metabolism*; D014801:Vitamin A / Q000378:metabolism
C112040:A2-E (N-retinylidene-N-retinylethanolamine); D008062:Lipofuscin; D011726:Pyridinium Compounds; D012176:Retinoids; D014801:Vitamin A; D012172:Retinaldehyde