FolM, a new chromosomally encoded dihydrofolate reductase in Escherichia coli.
Escherichia coli (thyA DeltafolA) mutants are viable and can grow in minimal medium when supplemented with thymidine alone. Here we present evidence from in vivo and in vitro studies that the ydgB gene determines an alternative dihydrofolate reductase that is related to the trypanosomatid pteridine reductases. We propose to rename this gene folM.
Giladi
Moshe
M
Department of Molecular Microbiology and Biotechnology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.
Altman-Price
Neta
N
Levin
Itay
I
Levy
Liat
L
Mevarech
Moshe
M
D000595:Amino Acid Sequence; D001708:Biopterins / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology*; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D009154:Mutation; D016415:Sequence Alignment; D013762:Tetrahydrofolate Dehydrogenase / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D013763:Tetrahydrofolates / Q000378:metabolism
D029968:Escherichia coli Proteins; D013763:Tetrahydrofolates; D001708:Biopterins; C030371:5,6,7,8-tetrahydrofolic acid; C479919:FolM protein, E coli; D013762:Tetrahydrofolate Dehydrogenase