title: Simultaneous registration and activation detection for fMRI.
abstract: Registration using the least-squares cost function is sensitive to the intensity fluctuations caused by the blood oxygen level dependent (BOLD) signal in functional MRI (fMRI) experiments, resulting in stimulus-correlated motion errors. These errors are severe enough to cause false-positive clusters in the activation maps of datasets acquired from 3T scanners. This paper presents a new approach to resolving the coupling between registration and activation. Instead of treating the two problems as individual steps in a sequence, they are combined into a single least-squares problem and are solved simultaneously. Robustness tests on a variety of simulated three-dimensional EPI datasets show that the stimulus-correlated motion errors are removed, resulting in a substantial decrease in false-positive and false-negative activation rates. The new method is also shown to decorrelate the motion estimates from the stimulus by testing it on different in vivo fMRI datasets acquired from two different 3T scanners.
authors: School of Computing Science, Simon Fraser University, Burnaby, BC V5A 1S6, Canada. jorchard@cs.uwaterloo.ca
authors: Jeff
authors: J
authors: Orchard
authors: Chen
authors: C
authors: Greif
authors: Gene H
authors: GH
authors: Golub
authors: Bruce
authors: B
authors: Bjornson
authors: M Stella
authors: MS
authors: Atkins
mesh_terms: D000465:Algorithms; D016477:Artifacts; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology; D001931:Brain Mapping / Q000379:methods*; D019416:Head Movements; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009038:Motion; D010100:Oxygen / Q000378:metabolism; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique
chemical_list: D010100:Oxygen