title: Role of regulatory T cells in allergy and asthma.
abstract: Th2 cells play a critical role in the pathogenesis of allergy and asthma. However, the immunological mechanisms that downmodulate and protect against the development of these disorders are poorly understood. A spectrum of CD4(+) T cells, including Th3 cells, T(R) cells, CD4(+)CD25(+) cells and NKT cells play a critical role in regulating these diseases. A better understanding of the role of regulatory cells in allergic diseases may lead to the identification of novel therapeutic targets.
authors: Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305-5208, USA.
authors: Omid
authors: O
authors: Akbari
authors: Philippe
authors: P
authors: Stock
authors: Rosemarie H
authors: RH
authors: DeKruyff
authors: Dale T
authors: DT
authors: Umetsu
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology*; D015704:CD4 Antigens / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007108:Immune Tolerance / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015704:CD4 Antigens; D015375:Receptors, Interleukin-2