title: Catalase-peroxidase activity has no influence on virulence in a murine model of tuberculosis.
abstract: The capacity to generate a chronic and persistent infection in the experimental murine model of tuberculosis induced aerogenically by a low-dose inoculum was determined in eight isoniazid-resistant clinical strains of Mycobacterium tuberculosis showing different catalase-peroxidase (C-P) activities. Determination of bacillary concentration in lung and spleen and the percentage of pulmonary parenchyma occupied by granulomas were monitored. Data showed no relation between the lack of C-P activity and the ability to develop a persistent infection, highlighting the potential of C-P negative strains to spread through the community.
authors: Unitat de Tuberculosi Experimental, Department of Microbiology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Crta del Canyet s/n, Badalona, 08916 Catalonia, Spain. pcardona@ns.hugtip.scs.es
authors: Pere Joan
authors: PJ
authors: Cardona
authors: Sergi
authors: S
authors: Gordillo
authors: Isabel
authors: I
authors: Amat
authors: Jorge
authors: J
authors: Díaz
authors: Joan
authors: J
authors: Lonca
authors: Cristina
authors: C
authors: Vilaplana
authors: Angeles
authors: A
authors: Pallarés
authors: Roger
authors: R
authors: Llatjós
authors: Aurelio
authors: A
authors: Ariza
authors: Vicenç
authors: V
authors: Ausina
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000378:metabolism*; D004195:Disease Models, Animal; D024881:Drug Resistance, Bacterial; D005260:Female; D005838:Genotype; D007538:Isoniazid / Q000627:therapeutic use; D008168:Lung / Q000382:microbiology / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000201:enzymology* / Q000472:pathogenicity*; D010544:Peroxidases / Q000378:metabolism*; D010641:Phenotype; D013053:Spectrophotometry / Q000379:methods; D014376:Tuberculosis / Q000201:enzymology / Q000382:microbiology* / Q000473:pathology; D018088:Tuberculosis, Multidrug-Resistant / Q000201:enzymology / Q000382:microbiology*; D014397:Tuberculosis, Pulmonary / Q000201:enzymology / Q000382:microbiology / Q000473:pathology; D014774:Virulence
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D010544:Peroxidases; C081610:catalase-peroxidase, bacteria; D007538:Isoniazid