Purinergic signaling along the renal tubule: the current state of play.
ATP-sensitive P2 receptors have been described in all mammalian nephron segments. A reductionist approach has demonstrated purinergic control of renal transporters in cell lines and heterologous expression systems. This brief update focuses on what is known of these receptors in native nephron segments (excluding the glomerulus) and outlines recent advances and possible future directions.
Unwin
Robert J
RJ
Centre for Nephrology, Department of Physiology, and Autonomic Neuroscience Institute, Royal Free and University College Medical School, London W1W 7EY, United Kingdom.
Bailey
Matthew A
MA
Burnstock
Geoffrey
G
D000818:Animals; D007668:Kidney / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism*; D007685:Kidney Tubules, Collecting / Q000378:metabolism; D007686:Kidney Tubules, Distal / Q000378:metabolism; D007687:Kidney Tubules, Proximal / Q000378:metabolism; D008138:Loop of Henle / Q000378:metabolism; D011687:Purines / Q000378:metabolism*; D018048:Receptors, Purinergic P2 / Q000378:metabolism; D015398:Signal Transduction
D011687:Purines; D018048:Receptors, Purinergic P2