Renal oncocytosis presenting in childhood: a case report.
Renal oncocytosis is a rare condition in which a spectrum of oncocytic lesions, including oncocytomas, diffusely involve the kidney. Few cases have been reported and all were in adult patients. We report here such a case in a 12-year-old girl. In addition to the unusual age at presentation, this case is remarkable for its heterogeneous tumor morphology, with some areas containing chromophobe carcinoma-like cells. Electron microscopy, immunohistochemistry, Hale's colloidal iron staining, and cytogenetics were performed to further evaluate the different morphologic areas. Our results suggest that the cells in the chromophobe carcinoma-like areas do not fulfill all the diagnostic criteria of chromophobe carcinoma. We caution pathologists in making a malignant diagnosis in such cases, especially in younger patients.
Chen
Terina S
TS
Department of Pathology and Laboratory Medicine, Rochester, New York 14642, USA.
McNally
Melanie
M
Hulbert
William
W
Di Sant'Agnese
P Anthony
PA
Huang
Jiaoti
J
D000230:Adenocarcinoma / Q000473:pathology; D018249:Adenoma, Oxyphilic / Q000473:pathology* / Q000503:physiopathology / Q000648:ultrastructure; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000648:ultrastructure; D008854:Microscopy, Electron