title: Immunoreactivity of brain-derived neurotrophic factor in rat dorsal root ganglion and spinal cord dorsal horn following exposure to herniated nucleus pulposus.
abstract: The pain mechanisms underlying radiculopathy due to disc herniation are still incompletely understood. This study assessed changes in brain-derived neurotrophic factor (BDNF) expression, a modulator of nociceptive information, in the dorsal root ganglion (DRG) and spinal cord dorsal horn following experimental disc herniation. Immunohistochemical analysis revealed an increase in percentage of BDNF-immunoreactive (IR) neurons profiles in the affected DRG and marked elevation in the BDNF-IR regions within both the superficial and deep layers at the corresponding spinal level with a peak at 3 days after nucleus pulposus (NP) application. These results thus show that herniated NP increases the BDNF production in the pain-processing neurons. Such changes can contribute to the development of inflammatory hyperalgesia.
authors: Department of Orthopaedics, Sahlgrenska University Hospital, Göteborg University, SE-413 45 Gothenburg, Sweden.
authors: Akira
authors: A
authors: Onda
authors: Yasuaki
authors: Y
authors: Murata
authors: Björn
authors: B
authors: Rydevik
authors: Karin
authors: K
authors: Larsson
authors: Shinichi
authors: S
authors: Kikuchi
authors: Kjell
authors: K
authors: Olmarker
mesh_terms: D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D005727:Ganglia, Spinal / Q000737:chemistry / Q000378:metabolism*; D007120:Immunochemistry; D007405:Intervertebral Disc Displacement / Q000378:metabolism*; D020671:Posterior Horn Cells / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019208:Brain-Derived Neurotrophic Factor