Microbial therapy of cancer: induction of apoptosis, recombinant vaccines, and inhibition of angiogenesis.
This review presents diverse approaches to cancer biotherapy including bacteriolytic therapy aimed at inducing apoptosis in tumor cells, bacterial vector-based cancer vaccines, and inhibition of tumor neoangiogenesis by microorganisms. The normal microflora in humans and animals may restrain malignant tumor regeneration.
Samuilov
V D
VD
Department of Physiology of Microorganisms, Faculty of Biology, Lomonosov Moscow State University, Moscow 119992, Russia. vds@8.cellimm.bio.msu.ru
D000818:Animals; D017209:Apoptosis; D001419:Bacteria / Q000235:genetics / Q000276:immunology*; D019496:Cancer Vaccines / Q000235:genetics / Q000276:immunology*; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D009389:Neovascularization, Pathologic
D019496:Cancer Vaccines