Intrauterine undernutrition--renal and vascular origin of hypertension.
A large number of clinical and experimental studies supports the hypothesis that intrauterine undernutrition is an important determinant of hypertension, coronary heart disease and non-insulin-dependent diabetes in the adult offspring. In this review, the renal and vascular repercussions of maternal undernutrition are emphasized, and the physiopatologic mechanisms discussed. The origin of hypertension is detailed based upon the findings of kidney functional parameters and endothelium function studies. A working model linking hypertension to intrauterine undernutrition is proposed.
do Carmo Pinho Franco
Maria
M
Departamento de Farmacologia, Instituto de Ciências Biomédicas I (ICB-I), Universidade de São Paulo, 05508-900, Av Prof Lineu Prestes, 1524, sala 205, São Paulo, SP, Brazil. mdcfranco@yahoo.com
Nigro
Dorothy
D
Fortes
Zuleica B
ZB
Tostes
Rita C A
RC
Carvalho
Maria Helena C
MH
Lucas
Sandra Regina Rodrigues
SR
Gomes
Guiomar Nascimento
GN
Coimbra
Terezila Machado
TM
Gil
Frida Zaladek
FZ
D000818:Animals; D001120:Arginine / Q000378:metabolism; D001682:Biological Availability; D005314:Embryonic and Fetal Development; D004730:Endothelium, Vascular / Q000503:physiopathology; D004967:Estrogens / Q000378:metabolism; D005260:Female; D005317:Fetal Growth Retardation / Q000150:complications*; D005783:Gender Identity; D005865:Gestational Age; D005938:Glucocorticoids / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D007668:Kidney / Q000196:embryology / Q000503:physiopathology; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D009569:Nitric Oxide / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D014666:Vasomotor System / Q000502:physiology
D004967:Estrogens; D005938:Glucocorticoids; D009569:Nitric Oxide; D001120:Arginine