[Content of protein lactoferrin in precancer laryngeal disease].
Lactoferrin was studied in 50 patients with laryngeal precancer: chronic hyperplastic laryngitis (n=28), leukoplakia (n=22). Lactoferrin was measured before the treatment, 10-12 days and 12 months after the treatment. Blood serum concentration of lactoferrin was significantly increased before the treatment. By the authors, it was due to inflammation in laryngeal tissues. Conservative treatment of patients with chronic hyperplastic laryngitis resulted in a considerable reduction in this protein concentration. Surgical removal of leukoplakias stimulated laryngeal inflammation and raised lactoferrin concentration in blood serum. One year after the examination, those patients who had neither exacerbation of chronic hyperplastic laryngitis no recurrent leukoplakia exhibited serum lactoferrin in concentrations close to the baseline but still higher than in healthy individuals. This is explained by chronicity of inflammation in laryngeal tissues. These findings can be used in diagnosis and prognosis of the disease course in patients with laryngeal precancer.
Osipov
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D000328:Adult; D006801:Humans; D007781:Lactoferrin / Q000097:blood*; D007822:Laryngeal Neoplasms / Q000097:blood*; D007972:Leukoplakia, Oral / Q000098:blood supply; D008297:Male; D011230:Precancerous Conditions
D007781:Lactoferrin