title: Phagocytosis by neutrophils.
abstract: Phagocytosis is central to the microbicidal function of neutrophils. Pathogens are initially engulfed into a plasma membrane-derived vacuole, the phagosome, which proceeds to acquire degradative properties by a complex process termed maturation. In this chapter, we discuss the current knowledge of the molecular mechanisms underlying phagosome formation and maturation in neutrophils.
authors: Cell Biology Program, Hospital for Sick Children and Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5G 1X8.
authors: Warren L
authors: WL
authors: Lee
authors: Rene E
authors: RE
authors: Harrison
authors: Sergio
authors: S
authors: Grinstein
mesh_terms: D000818:Animals; D006801:Humans; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis / Q000235:genetics / Q000502:physiology; D010588:Phagosomes / Q000502:physiology; D015398:Signal Transduction