title: Management of the primary cutaneous lymphomas.
abstract: Cutaneous lymphomas are rare and, although some are a manifestation of systemic lymphoma, the majority arise primarily from the skin. These primary cutaneous lymphomas comprise both T- and B-cell subtypes and represent a wide spectrum of disorders, which at times can be difficult to diagnose and classify. Classical therapeutic strategies include topical corticosteroids, phototherapy, radiotherapy, retinoids, extracorporeal photopheresis, topical chemotherapy, systemic chemotherapy and biological response modifiers. Newer therapies include the synthetic retinoid bexarotene, the immunotoxin conjugate denileukin diftitox, interleukin-12 and monoclonal antibodies such as alemtuzumab and rituximab.
authors: Department of Haematology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. miles.prince@petermac.org
authors: H Miles
authors: HM
authors: Prince
authors: Christopher
authors: C
authors: McCormack
authors: Gail
authors: G
authors: Ryan
authors: Rod
authors: R
authors: O'Keefe
authors: John F
authors: JF
authors: Seymour
authors: Chris
authors: C
authors: Baker
mesh_terms: D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001707:Biopsy, Needle; D003131:Combined Modality Therapy; D004502:Education, Medical, Continuing; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007155:Immunologic Factors / Q000627:therapeutic use; D016410:Lymphoma, T-Cell, Cutaneous / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D008297:Male; D009182:Mycosis Fungoides / Q000401:mortality / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D010789:Phototherapy / Q000379:methods; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D012751:Sezary Syndrome / Q000401:mortality / Q000473:pathology / Q000628:therapy; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D007155:Immunologic Factors