Concentration-independent spontaneously forming biomimetric vesicles.
In this Letter we present small-angle neutron scattering data from a biomimetic system composed of the phospholipids dimyristoyl and dihexanoyl phosphorylcholine (DMPC and DHPC, respectively). Doping DMPC-DHPC multilamellar vesicles with either the negatively charged lipid dimyristoyl phosphorylglycerol (DMPG, net charge -1) or the divalent cation, calcium (Ca2+), leads to the spontaneous formation of energetically stabilized monodisperse unilamellar vesicles whose radii are concentration independent and in contrast with previous experimental observations.
Nieh
M-P
MP
National Research Council, Steacie Institute for Molecular Sciences, Chalk River, Ontario, K0J 1J0, Canada.
Harroun
T A
TA
Raghunathan
V A
VA
Glinka
C J
CJ
Katsaras
J
J
D040761:Biomimetic Materials / Q000737:chemistry*; D002118:Calcium / Q000737:chemistry; D002413:Cations, Divalent; D004134:Dimyristoylphosphatidylcholine / Q000737:chemistry*; D007700:Kinetics; D008081:Liposomes / Q000737:chemistry*; D010742:Phospholipid Ethers / Q000737:chemistry*; D013816:Thermodynamics
C052298:1,2-dihexadecyl-sn-glycero-3-phosphocholine; D002413:Cations, Divalent; D008081:Liposomes; D010742:Phospholipid Ethers; D002118:Calcium; D004134:Dimyristoylphosphatidylcholine