Analysis of small molecule metabolism in zebrafish.
Recent work has shown that it is possible to assay phospholipid metabolism and prostanoid synthesis in zebrafish. These preliminary studies suggest that important questions of lipid biology are amenable to large-scale high-throughput analyses in this model system. Lipid metabolism can now be added to the growing list of vertebrate developmental and physiological processes that can be assayed in zebrafish. The potential to identify new genes, or novel functions of known genes that regulate dietary lipid metabolism, or the generation of lipid signaling molecules, may lead to the development of treatment strategies for common human diseases.
Ho
Shiu-Ying
SY
Department of Microbiology and Immunology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Pack
Michael
M
Farber
Steven A
SA
D000818:Animals; D004195:Disease Models, Animal; D050356:Lipid Metabolism; D008956:Models, Chemical; D013997:Time Factors; D015027:Zebrafish / Q000196:embryology / Q000235:genetics* / Q000378:metabolism*