title: Antiparasitic activity of highly conjugated pyrimidine-2,4-dione derivatives.
abstract: 4-[2-(1,3-Dimethyl-5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)vinyl]benzaldehyde was synthesized in four steps from 6-methyl-1H,3H-pyrimidine-2,4-dione. This aldehyde was functionalized by various substituted anilines or substituted benzylamines. Antiparasitic activities of the corresponding azomethines were assessed against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum compared to their toxicity versus human cells.
authors: Laboratoire de Parasitologie, EA 864, Faculté de Pharmacie, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France. nadine.azas@pharmacie.univ-mrs.fr
authors: Nadine
authors: N
authors: Azas
authors: Pascal
authors: P
authors: Rathelot
authors: Serge
authors: S
authors: Djekou
authors: Florence
authors: F
authors: Delmas
authors: A
authors: A
authors: Gellis
authors: Carole
authors: C
authors: Di Giorgio
authors: Patrice
authors: P
authors: Vanelle
authors: Pierre
authors: P
authors: Timon-David
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004912:Erythrocytes / Q000187:drug effects / Q000469:parasitology; D006801:Humans; D018314:Leishmania infantum / Q000187:drug effects / Q000254:growth & development; D009000:Monocytes / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects / Q000254:growth & development; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*; D014246:Trichomonas vaginalis / Q000187:drug effects / Q000254:growth & development
chemical_list: D000977:Antiparasitic Agents; D011743:Pyrimidines