Remarkable correlation between increased HLA-DQ antigen positive monocytes and prognosis of renal transplantation.
Since cyclosporin A (CsA), a widely used immunosuppressive drug, strongly suppresses interleukin-2 (IL-2) secretion, it is frequently difficult to estimate T lymphocyte activation in early acute rejection. We found that, when evaluated based on HLA-DQ antigen expression, monocyte activation in the peripheral blood of renal transplantation patients was a very sharp parameter in diagosing acute rejection. All of 16 episodes of early acute rejection, which were relatively easily suppressed by steroid pulse therapy, showed a sharp increase in the proportion of HLA-DQ antigen-positive monocytes (DQ+ mono) and a quick return of DQ+ mono to previous values, along with a fall in serum creatinine levels. Since, however, HLA-DR antigen-positive T lymphocytes (DR+ T) were markedly increased over a long period in episodes of therapy-resistant and chronic rejection, their prolonged high value was regarded as a parameter indicative of poor prognosis.
Fukuda
Y
Y
Second Department of Surgery, Hiroshima University School of Medicine, Hiroshima, Japan.
Ishikawa
T
T
Yahata
H
H
Marubayashi
S
S
Dohi
K
K
D002102:Cadaver; D003404:Creatinine / Q000097:blood; D005434:Flow Cytometry; D006084:Graft Rejection / Q000276:immunology*; D006683:HLA-DQ Antigens / Q000097:blood*; D006684:HLA-DR Antigens / Q000097:blood; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology* / Q000502:physiology; D019520:Living Donors; D009000:Monocytes / Q000276:immunology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012016:Reference Values; D017741:Survivors; D013997:Time Factors; D014019:Tissue Donors
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D003404:Creatinine