title: Some new 2,3,6-trisubstituted quinazolinones as potent anti-inflammatory, analgesic and COX-II inhibitors.
abstract: Various 2-(substitutedphenylmethyleneimino)aminoacetylmethylene-3-(2'-substitutedindol-3'-yl)-halosubstituted-4(3H)quinazolinones (5a-5i) and 2-(substituted phenylaminomethyleneacetyl-4'-oxo-1'-thiazolidinyl-3-(2"-substitutedindol-3"-yl) 4(3H)-quinazolinones (6a-6i) have been synthesized in the present studies. The structure of these compounds have been elucidated by elemental (C, H, N) and spectral (IR, 1H NMR and mass) analysis. Furthermore, above said compounds were evaluated for their anti-inflammatory, analgesic, ulcerogenic activities and acute toxicity study. Compound 6d was found to be most potent. Compound exihibiting less ulcerogenic liability and ALD(50) >2000mg/kg po.
authors: Medicinal Chemistry Division, Department of Pharmacology, L.L.R.M Medical College, (U.P.)-250004, Meerut, India. rajput_ak@indiatimes.com
authors: Ashok
authors: A
authors: Kumar
authors: Shalabh
authors: S
authors: Sharma
authors: Archana
authors: Kiran
authors: K
authors: Bajaj
authors: Shipra
authors: S
authors: Sharma
authors: Hemant
authors: H
authors: Panwar
authors: Tripti
authors: T
authors: Singh
authors: V K
authors: VK
authors: Srivastava
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology*; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D007527:Isoenzymes / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D011451:Prostaglandin-Endoperoxide Synthases / Q000187:drug effects*; D011799:Quinazolines / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013057:Spectrum Analysis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D011799:Quinazolines; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases