Induction of c-fos in nucleus accumbens in naive male Balb/c mice after wheel running.
Immunocytochemical labeling of the transcription factor c-Fos was used to determine whether wheel running (WR) activates nucleus accumbens (NAcc) neurons in naive male Balb/c mice. The results indicate compared to novel environment exploration and forced locomotor activity, WR increases c-Fos labeling in the middle level of the core but not the shell of the NAcc. These data show that WR activates middle-core NAcc neurons more effectively than other locomotor activities. The middle core of the NAcc may be a critical region for the self-reinforcing properties of WR.
Vargas-Pérez
Héctor
H
Departamento de Neurobiología Conductual y Cognitiva, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Apartado postal 1-1141, Querétaro, Qro. 76001, Mexico. vargas@calli.inb.unam.mx
Mena-Segovia
Juan
J
Giordano
Magda
M
Díaz
José Luis
JL
D000818:Animals; D005106:Exploratory Behavior / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000502:physiology*; D009714:Nucleus Accumbens / Q000737:chemistry / Q000378:metabolism*; D010805:Physical Conditioning, Animal / Q000379:methods; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics
D016760:Proto-Oncogene Proteins c-fos