Gut mucosal and plasma concentrations of glutamine: a comparison between two enriched enteral feeding solutions in critically ill patients.
BACKGROUND
Addition of glutamine to enteral nutrition formulas is consistently associated with a significant decrease in septic morbidity in critically ill patients, possibly related to the attenuation of gut dysfunction. This pilot study was undertaken to compare the effects of enteral administration of two glutamine-enriched formulas containing either additional free glutamine or glutamine-rich proteins, with a standard solution on plasma and mucosal concentrations of glutamine in patients admitted in the Department of Intensive Care.


METHODS
Following randomization, glutamine concentration was determined in endoscopically sampled duodenal biopsies and plasma, before and after a 7-day period of continuous administration of the designated solution.


RESULTS
The mucosal concentration of glutamine increased in the duodenal biopsies sampled from patients randomized to the solution containing the glutamine-rich proteins (from 3.6 +/- 2.2 to 6.7 +/- 5.2 micro-mol/g protein), but not from the others. There were no differences between the 3 groups in the plasma concentrations of glutamine, which remained stable over time.


CONCLUSIONS
The source of supplemental glutamine can influence gut mucosal glutamine concentrations, suggesting differences in its availability or utilization.
Preiser
Jean-Charles
JC
Department of Intensive Care, Centre Hospitalier Universitaire de Liège, Belgium. jean-charles.preiser@chu.ulg.ac.be
Peres-Bota
Daliana
D
Eisendrath
Pierre
P
Vincent
Jean-Louis
JL
Van Gossum
André
A