title: Effect of prostaglandin E1 on graft function of kidneys from living related donors.
abstract: Prostaglandin E1 (PGE1) was used in renal transplant recipients with living related donors. The drug was given intravenously from day 1 to day 7 after transplantation at a dose of 40 microg/kg twice a day. A total of 45 patients were studied divided into two groups: 25 patients were treated with PGE1 (group B) and the remaining 20 patients did not receive the drug (group A). In group B, 24-h creatinine clearance (Ccr) was 66 +/- 12.8 ml/min compared with 40.3 +/- 13.4 ml/min in group A on the fifth postoperative day (P < 0.05). Urinary levels of N-acetyl-beta-D-glucosaminidase (NAG) and serum levels of platelet factor 4 (PF4) in group B were significantly lower than in group A. On the fourth postoperative day, the urinary excretion of thromboxan B2 (TxB2) in group A was higher than in group B, but not significantly (5.1 +/- 3.0 ng/day and 2.8 +/- 1.1 ng/day, respectively). Acute rejection occurred in four patients in group B and in 10 patients (40%) in group A. The percentage of Leu2a-positive lymphocytes in group B was higher than in group A. We conclude that postoperative administration of PGE1 improves graft function in kidneys from living related donors.
authors: Third Department of Surgery, Tokyo Women's Medical College, 8-1 Kawada-cho Sinjuku-ku, Tokyo, Japan.
authors: S
authors: S
authors: Ohsaki
authors: S
authors: S
authors: Teraoka
authors: T
authors: T
authors: Tojimbara
authors: K
authors: K
authors: Takahasi
authors: H
authors: H
authors: Toma
authors: T
authors: T
authors: Agishi
authors: K
authors: K
authors: Ota
mesh_terms: D000328:Adult; D000527:Alprostadil / Q000627:therapeutic use*; D001787:Blood Group Incompatibility; D003404:Creatinine / Q000097:blood; D005190:Family; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D010978:Platelet Factor 4 / Q000378:metabolism; D013929:Thromboxane B2 / Q000652:urine
chemical_list: D010978:Platelet Factor 4; D013929:Thromboxane B2; D003404:Creatinine; D000527:Alprostadil