title: Solid phase synthesis of 2-aminoquinazoline-based compounds.
abstract: A versatile method for the solid-phase synthesis of 2-aminoquinazoline-based derivatives, 3-substituted-3,4-dihydroquinazolin-2-amines and imidazoquinazolines, has been developed. They were obtained by treating the amino group of polymer-linked amino acids with 2-nitrobenzaldehyde followed by reduction of the nitro group to an amine. Cyclization of the resulting immobilized intermediates with cyanogen bromide followed by acidic/basic cleavage yielded the desired quinazoline-based compounds in high yields and purities.
authors: Medicinal Chemistry Division and NMR Lab, Sophisticated Analytical Instrumentation Facility, Central Drug Research Institute, Lucknow 226001, India.
authors: Gaurav K
authors: GK
authors: Srivastava
authors: Amit P
authors: AP
authors: Kesarwani
authors: Rajesh K
authors: RK
authors: Grover
authors: Raja
authors: R
authors: Roy
authors: T
authors: T
authors: Srinivasan
authors: Bijoy
authors: B
authors: Kundu
mesh_terms: D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D000634:Aminoquinolines