From beta-N-tert-butyloxycarbonyl N-carboxyanhydrides to beta-aminoacid derivatives.
beta-N-tert-butyloxycarbonyl-N-carboxyanhydrides are very reactive beta-amino acid derivatives. They react cleanly and smoothly with different nucleophiles like aminoesters, enolates, N-methyl-d-glucamine, amidoximes to afford in good to excellent yields peptides, beta-amino ketocompounds, beta-aminosugars and functionalized disubstituted 1,2,4-oxadiazoles.
Huck
J
J
UMR 5810, CNRS-LAPP Universités Montpellier I et II Place E, Bataillon 34095, Montpellier, Cédex, France. Jackhuck@chererful.com
Roumestant
M L
ML
Martinez
J
J
D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D000812:Anhydrides / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000596:Amino Acids; D000812:Anhydrides