title: Desquamative gingivitis: early presenting symptom of mucocutaneous disease.
abstract: Desquamation of the gingiva is a sign that may be encountered in clinical practice. Various diseases can affect the gingival tissues. Mild desquamation that is localized may be associated with mechanical irritation or induced by trauma. Moderate to severe generalized desquamation associated with ulceration and erythema may be indicative of a more serious systemic condition. Although often overlooked, mucocutaneous diseases frequently present with gingival desquamation as an early presenting symptom. The most common mucocutaneous diseases that affect the oral cavity are lichen planus, pemphigus, and mucous membrane pemphigoid. This article reviews the etiology, signs and symptoms, and therapies for these disorders. Increased knowledge of mucocutaneous diseases can help the clinician recognize these disorders and enable the patient to receive appropriate therapy.
authors: Department of Oral Medicine, University of Pennsylvania School of Dental Medicine, Philadelphia, Pennsylvania 19104, USA. ets@pobox.upenn.edu
authors: Eric T
authors: ET
authors: Stoopler
authors: Thomas P
authors: TP
authors: Sollecito
authors: Scott S
authors: SS
authors: DeRossi
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000188:drug therapy; D001706:Biopsy; D002990:Clobetasol / Q000627:therapeutic use; D003622:Dapsone / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005447:Fluocinonide / Q000627:therapeutic use; D005891:Gingivitis / Q000175:diagnosis* / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D017676:Lichen Planus, Oral / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D010390:Pemphigoid, Benign Mucous Membrane / Q000175:diagnosis* / Q000188:drug therapy; D010392:Pemphigus / Q000175:diagnosis* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D005447:Fluocinonide; D003622:Dapsone; D002990:Clobetasol; D011241:Prednisone