Ethanol-oxidizing and NO-synthesizing enzymes in monoaminergic nuclei of human brain.
Serotonin-, dopamine-, and noradrenergic nuclei in human brainstem were examined histochemically for alcohol dehydrogenase, aldehyde dehydrogenase, and NADPH diaphorase. The findings indicate that monoaminergic centers are characterized by different repertoire of NO-ergic and ethanol-oxidizing enzymes, whose distribution correlates with the transmitter specialization of neurons.
Konovko
O O
OO
Department of Histology, Vladivostok State Medical University, Vladivostok.
Dyuizen
I V
IV
Motavkin
P A
PA
D000426:Alcohol Dehydrogenase / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001933:Brain Stem / Q000033:anatomy & histology / Q000201:enzymology*; D000431:Ethanol / Q000378:metabolism*; D006801:Humans; D009252:NADPH Dehydrogenase / Q000378:metabolism; D009474:Neurons / Q000737:chemistry / Q000166:cytology / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats
D015306:Biogenic Monoamines; D009569:Nitric Oxide; D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000444:Aldehyde Dehydrogenase; D009252:NADPH Dehydrogenase