The relationship between membrane pathology and language disorder in schizophrenia.
Receptive language disorder in schizophrenia has been hypothesized to involve a fundamental deficit in the temporal (time-based) dynamics of brain function that includes disruptions to patterns of activation and synchronization. In this paper, candidate mechanisms and pathways that could account for this basic deficit are discussed. Parallels are identified between the patterns of language dysfunction observed for schizophrenia and dyslexia, two separate clinical disorders that may share a common abnormality in cell membrane phospholipids. A heuristic is proposed which details a trajectory involving an interaction of brain fatty acids and second-messenger function that modulates synaptic efficacy, and, in turn, influences language processing in schizophrenia patients. It is additionally hypothesized that a primary deficit of functional excitation originating in the cerebellum, in combination with a compensatory decrease of functional inhibition in the prefrontal cortex, influences receptive language dysfunction in schizophrenia.
Condray
Ruth
R
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA. condrayr@msx.upmc.edu
Glasgow
Angela G
AG
D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002462:Cell Membrane / Q000378:metabolism* / Q000473:pathology; D004410:Dyslexia / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007806:Language Disorders / Q000503:physiopathology*; D008563:Membrane Lipids / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D012559:Schizophrenia / Q000473:pathology / Q000503:physiopathology*
D008563:Membrane Lipids; D010743:Phospholipids