[The PATCHED/Sonic Hedgehog signalling pathway in superficial bladder cancer].
Superficial bladder cancer shows a high frequency of total or partial chromosome 9 losses. Loss of heterozygosity at position 9q22.3 is one of the most frequent and is associated with highly recurrent tumours. The PATCHED gene, ortholog of a gene first described in the drosophila as a segment polarity gene, is located at 9q22.3. It is a member of a signal transduction pathway and a tumour suppressor gene (TSG), involved in basal cell carcinoma. We propose PATCHED as a TSG candidate in superficial bladder cancer.
LaRue
Hélène
H
Centre de recherche en cancérologie de l'Université Laval, CHUQ-L'Hôtel-Dieu de Québec, 10, rue MacMahon, G1R 2J6 Québec, Canada.
Simoneau
Maryse
M
Aboulkassim
Tahar O
TO
Lemieux
Patricia
P
Girard
Johanne
J
Hamed
Sahar
S
Hovington
Hélène
H
Jeannotte
Lucie
L
Fradet
Yves
Y
D002280:Basal Cell Carcinoma / Q000235:genetics* / Q000503:physiopathology*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D016147:Genes, Tumor Suppressor; D006801:Humans; D019656:Loss of Heterozygosity; D008565:Membrane Proteins / Q000235:genetics* / Q000494:pharmacology*; D000072079:Patched Receptors; D011956:Receptors, Cell Surface; D015398:Signal Transduction; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000503:physiopathology*
D008565:Membrane Proteins; D000072079:Patched Receptors; D011956:Receptors, Cell Surface