title: Inhibitory effects of plant-derived flavonoids and phenolic acids on malonaldehyde formation from ethyl arachidonate.
abstract: The antioxidant activities of naturally occurring plant compounds were measured in a lipid peroxidation system consisting of ethyl arachidonate and Fenton's reagent. Inhibitory effects of 24 plant-derived flavonoids and 5 phenolic acids on malonaldehyde (MA) formation from ethyl arachidonate were examined using gas chromatography (GC) with a nitrogen-phosphorus detector (NPD). Luteolin, which showed the strongest antioxidant activity, inhibited MA formation by 94% and 97% at the levels of 0.5 and 1.0 mM, respectively. The antioxidant activities of the flavones and flavonols decreased in the following order: luteolin > rhamnetin > fisetin > kaempferol > morin > quercetin. Among the flavanones tested, hesperitin, taxifolin, and naringenin exhibited appreciable antioxidant activities (61-84%) at the 1.0 mM level. The inhibitory effect of epigallocatechin gallate (82.5% at the 1.0 mM level) was the strongest among the flavan-3-ols tested. Ferulic acid had the most potent antioxidant activity (74.6% at the 1.0 mM level) of the phenolic acids tested.
authors: Department of Food Science and Technology, Dongguk University, 3-26 Pil-dong, Chung-gu, Seoul 100-715, Korea.
authors: Kwang-Geun
authors: KG
authors: Lee
authors: Takayuki
authors: T
authors: Shibamoto
authors: Gary R
authors: GR
authors: Takeoka
authors: Sung-Eun
authors: SE
authors: Lee
authors: Jeong-Han
authors: JH
authors: Kim
authors: Byeoung-Soo
authors: BS
authors: Park
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D001095:Arachidonic Acids / Q000737:chemistry*; D002849:Chromatography, Gas; D044950:Flavanones / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology*; D044948:Flavonols / Q000494:pharmacology; D006861:Hydrogen Peroxide / Q000737:chemistry; D062385:Hydroxybenzoates / Q000494:pharmacology*; D007501:Iron / Q000737:chemistry; D015227:Lipid Peroxidation; D047311:Luteolin; D008315:Malondialdehyde / Q000737:chemistry*; D010084:Oxidation-Reduction; D010944:Plants / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001095:Arachidonic Acids; C045076:Fenton's reagent; D044950:Flavanones; D005419:Flavonoids; D044948:Flavonols; D062385:Hydroxybenzoates; C035723:ethyl arachidonate; D008315:Malondialdehyde; D006861:Hydrogen Peroxide; D007501:Iron; C017616:phenolic acid; D047311:Luteolin