title: Hepatic cirrhosis occurring in a young woodchuck (Marmota monax) due to vertical transmission of woodchuck hepatitis virus (WHV).
abstract: Histologic and clinicopathologic findings of a woodchuck (Marmota monax) vertically infected with woodchuck hepatitis virus (WHV) are presented. The liver exhibits marked cirrhotic changes, which is characteristic of the pre-transformation phase of WHV. At necropsy, the woodchuck exhibited ascites and the liver had a grossly nodular appearance. Microscopically, focal hepatocyte necrosis and inflammatory cells were observed in midzonal and periportal areas in the liver. In Macchiavellos stained sections, cytoplasmic inclusion bodies appeared reddish granular materials. We believe that this may represent a new suitable and cost-effective cirrhotic model for the disease processes associated with hepadnaviruses in a number of other species, most notably Hepatitis B virus infection in man.
authors: College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea.
authors: Da-hee
authors: DH
authors: Jeong
authors: Won-il
authors: WI
authors: Jeong
authors: Jae-yong
authors: JY
authors: Chung
authors: Mi-young
authors: MY
authors: An
authors: Chae-yong
authors: CY
authors: Jung
authors: Gyoung-jae
authors: GJ
authors: Lee
authors: Jong-soo
authors: JS
authors: Kang
authors: Byeong-cheol
authors: BC
authors: Kang
authors: Young-heun
authors: YH
authors: Jee
authors: Bruce H
authors: BH
authors: Williams
authors: Young-oh
authors: YO
authors: Kwon
authors: Kyu-shik
authors: KS
authors: Jeong
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D006509:Hepatitis B / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D017919:Hepatitis B Virus, Woodchuck / Q000302:isolation & purification*; D008103:Liver Cirrhosis / Q000097:blood / Q000473:pathology / Q000662:veterinary*; D008392:Marmota; D012016:Reference Values; D012376:Rodent Diseases / Q000097:blood / Q000473:pathology*
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase