Primary Ewing's sarcoma of the suodenum: a case report.
We report a case of Ewing's sarcoma arising from the duodenum in a 20-year-old woman who presented with a rapidly progressive ulcerative lesion. The surgical specimen obtained via Whipple's operation revealed a small round-cell tumor (SRCT) in the first and second portion of the duodenum. The tumor cells revealed strong immunore-activity for CD 99 and vimentin and focal paranuclear dot-like immunoreactivity for cytokeratin. Electron microscopy showed primitive tumor cells with few cytoplasmic organelles, but neither neurosecretory granules nor specific cell junctions were present. On Western blot study, 68-kDa EWS/FLI1 fusion protein was detected. The occurrence of Ewing's sarcoma in the gastrointestinal hollow viscus has recently been recognized, and this case expands the known anatomic sites that can harbor Ewing's sarcoma by demonstrating primary duodenal involvement.
Kie
Jeong-Hae
JH
Department of Pathology, National Health Insurance Cooperation Ilsan Hospital, Koyang, Korea.
Lee
Mi-Kyung
MK
Kim
Chong-Jai
CJ
Lee
Kyibeom
K
Kwon
Kuk-Whan
KW
Yang
Woo-Ick
WI
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D015153:Blotting, Western; D004379:Duodenal Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D015514:Oncogene Proteins, Fusion / Q000378:metabolism; D051789:Proto-Oncogene Protein c-fli-1; D034802:RNA-Binding Protein EWS; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012512:Sarcoma, Ewing / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D014157:Transcription Factors / Q000378:metabolism
D014408:Biomarkers, Tumor; C106031:EWS-FLI fusion protein; D015514:Oncogene Proteins, Fusion; D051789:Proto-Oncogene Protein c-fli-1; D034802:RNA-Binding Protein EWS; D014157:Transcription Factors