title: Divergent effects of soy protein diet on the expression of adipocytokines.
abstract: Adipose tissue secretes various bioactive molecules called adipocytokines. Dysregulation of adipocytokines plays an important role in the development of atherosclerotic vascular diseases. Consumption of vegetable protein reduces the risks of atherosclerotic vascular diseases. Here, we investigated the effects of 10-day dietary soy protein isolate (SPI) on the regulation of adipocytokines in Wistar rats. No significant difference in body weight was observed between SPI and Casein (animal protein) group. Expression of adipose PAI-1 was lower and expression and plasma concentration of adiponectin were higher in SPI than Casein group. Triglyceride content was lower and fatty acid synthase mRNA level in adipose tissue was lower in SPI than Casein group. Although SREBP-1 mRNA expression was decreased in the liver of SPI group, adipose SREBP and PPARgamma mRNA levels remained unchanged. Our data suggest that dietary SPI alters the gene expressions in adipose tissue and has beneficial effects on the expression of adipocytokines.
authors: Department of Molecular Science and Internal Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan.
authors: Azumi
authors: A
authors: Nagasawa
authors: Kensuke
authors: K
authors: Fukui
authors: Makiko
authors: M
authors: Kojima
authors: Ken
authors: K
authors: Kishida
authors: Norikazu
authors: N
authors: Maeda
authors: Hiroyuki
authors: H
authors: Nagaretani
authors: Toshiyuki
authors: T
authors: Hibuse
authors: Hitoshi
authors: H
authors: Nishizawa
authors: Shinji
authors: S
authors: Kihara
authors: Masako
authors: M
authors: Waki
authors: Kiyoharu
authors: K
authors: Takamatsu
authors: Tohru
authors: T
authors: Funahashi
authors: Yuji
authors: Y
authors: Matsuzawa
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism*; D000284:Administration, Oral; D000818:Animals; D001823:Body Composition / Q000187:drug effects / Q000502:physiology; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D002364:Caseins / Q000008:administration & dosage*; D016207:Cytokines / Q000097:blood / Q000378:metabolism*; D004044:Dietary Proteins / Q000008:administration & dosage*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D030262:Soybean Proteins / Q000008:administration & dosage*
chemical_list: D002364:Caseins; D016207:Cytokines; D004044:Dietary Proteins; D030262:Soybean Proteins