title: Synthesis and hypolipidemic activity of N-substituted phthalimides. Part V.
abstract: A series of N-aryl- or N-(1,2,4-triazol-yl)-phthalimides (4a-4i) have been synthesized starting from phthalic anhydride (1) and an appropriate amine (2a-2i). All compounds presented hypolipidemic activity, but compound 4d proved to be the most active and reduced plasma cholesterol and triglyceride levels in Swiss white mice significantly.
authors: Departamento de Química Fundamental, Universidade Federal de Pernambuco (UFPE), Av. Luis Freire, S/N, Cidade Universitária, CEP 50.740-540 Recife, PE, Brazil.
authors: Vera L M
authors: VL
authors: Sena
authors: Rajendra M
authors: RM
authors: Srivastava
authors: Ricardo O
authors: RO
authors: Silva
authors: Vera L M
authors: VL
authors: Lima
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D051379:Mice; D010797:Phthalimides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D000960:Hypolipidemic Agents; D010797:Phthalimides; D014280:Triglycerides; D002784:Cholesterol