Cytogenetic evidence for the origin of neoplastic cells in CD5-positive marginal zone B-cell lymphoma.
We describe an 87-year-old female patient presenting with a breast lump and axillary lymphadenopathy. Histological examination revealed the lump to be a CD5-positive extranodal marginal zone B-cell lymphoma (MZBCL) of mucosa-associated lymphoid tissue. Subsequent staging revealed disseminated disease including the head and neck region. Only 2 cases of CD5-positive MZBCL have undergone any form of cytogenetic analysis, and we report the first standard karyotype of such a case. This revealed partial trisomy 3,7q deletion and an additional marker chromosome. Notably, cells lacked the t(11;14) found at high frequency in mantle cell lymphoma and trisomy 12 found in B small lymphocytic lymphoma (B-SLL). These results, combined with the clinical, histological, and immunophenotypic picture, suggest a marginal zone origin for the neoplastic lymphocytes, rather than a relationship with mantle cell or small lymphocytic lymphoma.
Batstone
Paul
P
Pathology Department, Highland Acute Hospitals NHS Trust, Raigmore Hospital, Inverness, Scotland, UK.
Forsyth
Linda
L
Goodlad
John R
JR
D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle; D018956:CD5 Antigens / Q000378:metabolism; D002869:Chromosome Aberrations; D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D010166:Palliative Care; D032681:Spectral Karyotyping
D018956:CD5 Antigens