[Influenza virus infection and apoptosis].
Many viruses including influenza virus induce apoptosis of host cells. Influenza virus-induced apoptosis shares common features of apoptosis, i.e. activation of caspases and inhibition by bcl-2. Fas and its ligand and double stranded-RNA activated-protein kinase (PKR) are partly involved in the apoptosis. Virus proteins as nonstructural protein I, neuraminidase as well as a novel protein, PB1-F2, play some roles in promoting the virus-induced apoptosis. Apoptotic cells are effectively engulfed by macrophages, which recognize phosphatidylserine on the outer leaflet of the membrane of apoptotic cell. Neuraminidase activity is required for the effective phagocytosis. All these evidence suggest that the virus-induced apoptosis is one of the mechanisms of host defense system.
Takizawa
Takenori
T
Department of Biochemistry, Institute for Developmental Research, Aichi Human Service Center.
D017209:Apoptosis; D020169:Caspases / Q000378:metabolism; D053222:Fas Ligand Protein; D006801:Humans; D007251:Influenza, Human / Q000276:immunology* / Q000821:virology; D008264:Macrophages / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000502:physiology; D009439:Neuraminidase / Q000502:physiology; D009975:Orthomyxoviridae / Q000201:enzymology / Q000502:physiology*; D010587:Phagocytosis; D014764:Viral Proteins / Q000502:physiology; D014779:Virus Replication; D019892:eIF-2 Kinase / Q000502:physiology; D019014:fas Receptor / Q000502:physiology
C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D014764:Viral Proteins; D019014:fas Receptor; C077346:influenza virus polymerase basic protein 1; D019892:eIF-2 Kinase; D009439:Neuraminidase; D020169:Caspases