[A case of advanced gastric cancer that had invaded the duodenum treated with combined chemotherapy using TS-1 and low-dose CDDP, which prevented the need for a pancreaticoduodenectomy].
A 59-year-old woman visited our hospital with a chief complaint of body weight loss and abdominal distension. Gastrofiberscopy revealed a gastric tumor that had invaded the duodenum of the second portion. The patient was treated with combined chemotherapy using TS-1 and CDDP, as it was deemed necessary to perform a pancreaticoduodenectomy for surgical curative resection. TS-1 (80 mg/m2) was orally administered for 3 weeks and CDDP (6 mg/m2) was simultaneously administered 3 times for 5 days each followed by a 2-day interval (for 3 weeks). The patient experienced grade 3 leukocytopenia. Endoscopic examination revealed partial response after chemotherapy. The patient was subjected to curative distal gastrectomy. Pathological efficacy was Grade 1b. Adjuvant chemotherapy was provided following the same regimen because of its pathological efficacy and the absence of severe adverse events. Six months after the operation, the patient was very healthy and showed no signs of recurrence of cancer. This TS-1/CDDP combination chemotherapy was suitable as neoadjuvant chemotherapy because of its rapid effect.
Egawa
Tomohisa
T
Dept. of Surgery, Saiseikai Kanagawaken Hospital.
Nagashima
Atsushi
A
Kitano
Mitsuhide
M
Doi
Masakazu
M
Hayashi
Shinobu
S
Yoshii
Hiroshi
H
D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004379:Duodenal Neoplasms / Q000473:pathology*; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D010094:Oxonic Acid / Q000008:administration & dosage; D016577:Pancreaticoduodenectomy; D011725:Pyridines / Q000008:administration & dosage; D012074:Remission Induction; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage
D004338:Drug Combinations; D011725:Pyridines; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin