Renal angioplasty and stenting with distal protection of the main renal artery in ischemic nephropathy: early experience.
OBJECTIVE
We present a retrospective review of a single tertiary hospital experience in renal artery stent revascularization with distal protection in patients with ischemic nephropathy. The objectives of the study included preliminary assessment of the effect of distal protection on procedure-related acute deterioration in renal function and on renal salvage.


METHODS
All patients had significant atherosclerotic main renal artery stenosis, documented at preprocedural imaging, and a degree of chronic renal impairment before revascularization. Forty-six renal arteries were treated in 37 patients with preprocedural renal impairment, which was mild in 10 patients, moderate in 19 patients, and severe in 8 patients. Median patient age was 72 years (range, 59-85 years). All patients underwent primary stenting of renal artery ostial stenoses with adjuvant use of a filter device (Angioguard guide wire system; Cordis Corp, Division of Johnson & Johnson, Miami, Fla) in the distal main renal artery. The filter baskets were recaptured for pathologic analysis.


RESULTS
Overall, in 95% of patients, including all patients with preprocedural mild or moderate renal impairment, renal function was stabilized or improved after revascularization. In 5% of patients decline in renal function was unchanged. No patients had acute postprocedural deterioration. Mean follow-up was 12.5 months (range, 2-28 months). These results are better than in most reports in the literature and also better than in a historical group of similar patients with ischemic nephropathy who underwent stent revascularization without distal protection at the same institution. The improved results are thought to be due to prevention of cholesterol atheroembolization during the procedure by the distal filter baskets. Sixty-five percent of the distal protection baskets contained embolic material, including fresh thrombus, chronic thrombus, atheromatous fragments, and cholesterol clefts.


CONCLUSIONS
A distal protection device may significantly improve results during stent revascularization. There are a number of unique demands on a renal protection device, and the ideal device has not yet been developed.
Holden
Andrew
A
Department of Radiology, Auckland Hospital, New Zealand. andrewh@adhb.govt.nz
Hill
Andrew
A
D000368:Aged; D000369:Aged, 80 and over; D000800:Angioplasty, Balloon / Q000009:adverse effects* / Q000295:instrumentation / Q000379:methods*; D004864:Equipment and Supplies; D005260:Female; D006801:Humans; D007511:Ischemia / Q000209:etiology*; D007668:Kidney / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D012078:Renal Artery Obstruction / Q000150:complications / Q000628:therapy*; D012189:Retrospective Studies; D015607:Stents; D013923:Thromboembolism / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome