title: Comparative map between chicken chromosome 15 and human chromosomal region 12q24 and 22q11-q12.
abstract: The physical and comparative map of GGA15 was improved by the construction of 9 BAC contigs around loci previously mapped on GGA15 by linkage analysis. In total, 240 BAC clones were isolated, covering 30-35% of GGA15, and 120 STS were developed (104 STS derived from BAC end sequences and 18 STS derived within genes). Seventeen chicken orthologues of human genes located on human Chr 22q11-q12 were directly mapped within BAC contigs of GGA15. Furthermore, the partial sequences of the chicken BAC clones were compared with sequences present in the EMBL/GenBank databases and revealed matches to 26 genes, ESTs, and genomic clones located on HSA22q11-q12 and HSA12q24. These results provide a better alignment of GGA15 with the corresponding regions in human and mouse, and improve our knowledge of the evolution and dynamics of the vertebrate genome.
authors: Wageningen Institute of Animal Sciences, Animal Breeding and Genetics Group, Wageningen University, Marijkeweg 40, 6709 PG Wageningen, The Netherlands. danyel.jennen@wur.nl
authors: Danyel G J
authors: DG
authors: Jennen
authors: Richard P M A
authors: RP
authors: Crooijmans
authors: Bram
authors: B
authors: Kamps
authors: Rukiye
authors: R
authors: Açar
authors: Jan J
authors: JJ
authors: van der Poel
authors: Martien A M
authors: MA
authors: Groenen
mesh_terms: D000818:Animals; D001483:Base Sequence; D002645:Chickens / Q000235:genetics*; D002874:Chromosome Mapping; D022202:Chromosomes, Artificial, Bacterial / Q000235:genetics; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D020451:Contig Mapping; D004247:DNA / Q000235:genetics; D015321:Gene Rearrangement; D005819:Genetic Markers; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D013045:Species Specificity; D038204:beta-Crystallins / Q000235:genetics
chemical_list: D005819:Genetic Markers; D038204:beta-Crystallins; D004247:DNA