Microwave-assisted synthesis utilizing supported reagents: a rapid and efficient acylation procedure.
[reaction: see text] The application of microwave heating to a polymer-assisted solution-phase (PASP) synthesis technique has been utilized to develop a rapid and efficient protocol for the solution-phase synthesis of amides from either amine or carboxylic acid cores.
Sauer
Daryl R
DR
High-Throughput Organic Synthesis Group, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6113, USA. daryl.r.sauer@abbott.com
Kalvin
Douglas
D
Phelan
Kathleen M
KM