Cardiovascular risk in women with type 2 diabetes.
Type 2 DM appears to eliminate the relative survival advantage experienced by premenopausal nondiabetic women compared with men with regard to CVD. The role of traditional cardiovascular risk factors, while important, cannot fully account for the disparate increase in CVD among women with type 2 DM compared with nondiabetic women. The interplay between type 2 DM and female hormones may prove important. Other less traditional risk factors such as endothelial dysfunction and impaired fibrinolysis may also play a role. Impairments in cardiovascular exercise performance in women with type 2 DM may provide insight in the future as representative of a pre-CVD state. Future research should focus on the specific causes of CVD in women with DM. In the meantime, it is important to aggressively treat modifiable risk factors in this population (Table 1). The impact of this health problem will continue to increase in our aging society, because a steadily increasing proportion of the population will be women; furthermore, an increasing percentage of these women will have diabetes if current trends continue.
Brandenburg
Suzanne L
SL
Division of General Internal Medicine, Department of Medicine, University of Colorado Health Sciences Center, Box B-180, 4200 East 9th Avenue, Denver, CO 80262, USA. suzanne.brandenburg@uchsc.edu
Lindenfeld
JoAnn
J
Reusch
Jane E B
JE
Regensteiner
Judith G
JG
D000428:Alcohol Drinking / Q000009:adverse effects; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology*; D015444:Exercise; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D006973:Hypertension / Q000150:complications; D007249:Inflammation / Q000150:complications; D009765:Obesity / Q000150:complications; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014481:United States