title: An elevated value of C-reactive protein is the only predictive factor of restenosis after percutaneous coronary intervention.
abstract: BACKGROUND
  The current techniques for percutaneous coronary interventions (PCI) remain limited by restenosis. Recent studies have provided evidence of inflammation playing a role in the pathogenesis of cardiovascular disease.
  
  
  METHODS
  Whether inflammatory markers are predictors of subsequent restenosis were prospectively tested in 272 consecutive patients with angiographically proven coronary artery disease. Patients having undergone PCI at Chonnam National University Hospital, between Sept. 1999 and Mar. 2001, were divided into two groups according to the occurrence of restenosis on a follow-up coronary angiogram: Group I were patients with restenosis (n = 99, 59.5 +/- 10.8 years, M:F = 77:22) and Group II were those without restenosis (n = 173, 58.8 +/- 10.2 years, M:F = 131:42). The IgG seropositivity, cytomegalovirus (CMV) titers, C. pneumoniae. H. pylori and levels of C-reactive protein (CRP) were compared between the two groups.
  
  
  RESULTS
  There were no statistical differences in the seropositivity of the CMV IgG C. pneumoniae IgG and H. pylori IgG between the two groups (Groups I vs. II: 100 vs. 100%, 24.7 vs. 25.7% and 62.2 vs. 63.7%, respectively). Of the angiographic parameters, a low Thrombolysis in Myocardial Infarction (TIMI) flow (TIMI 0 or 1) was more common in Group I than Group II (p = 0.038). The patients with an elevated CRP (> 0.5 mg/dL) were more common in Group I than Group II (57.6 vs. 36.4%, p = 0.001), with the CRP values being higher in Group I than Group II (3.3 +/- 5.8 vs. 1.3 +/- 2.6 mg/dL, p = 0.001). According to a multiple logistic regression analysis, the CRP was the only predictor of restenosis, with an odds ratio of 2.1169 (95% C.I. 1.2062-3.7154, p = 0.009).
  
  
  CONCLUSIONS
  The CRP value is the most important predictor of restenosis after PCI.
authors: Cardiac Catheterization Laboratory, Heart Center of Chonnam National University Hospital, Hakdong 8, Dong-gu, Gwangju, 501-757, Korea.
authors: Woo Kon
authors: WK
authors: Jeong
authors: Myung Ho
authors: MH
authors: Jeong
authors: Kye Hun
authors: KH
authors: Kim
authors: Sang Rok
authors: SR
authors: Lee
authors: Ok Young
authors: OY
authors: Park
authors: Ju Hyup
authors: JH
authors: Yum
authors: Joo Han
authors: JH
authors: Kim
authors: Won
authors: W
authors: Kim
authors: Jae Young
authors: JY
authors: Rhew
authors: Youn Keun
authors: YK
authors: Ahn
authors: Jeong Gwan
authors: JG
authors: Cho
authors: Byoung Hee
authors: BH
authors: Ahn
authors: Soon Pal
authors: SP
authors: Suh
authors: Jong Chun
authors: JC
authors: Park
authors: Sang Hyung
authors: SH
authors: Kim
authors: Jung Chaee
authors: JC
authors: Kang
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D000907:Antibodies, Bacterial / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D015415:Biomarkers / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis*; D016993:Chlamydophila pneumoniae / Q000276:immunology; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000097:blood* / Q000175:diagnosis / Q000628:therapy*; D003587:Cytomegalovirus / Q000276:immunology; D005260:Female; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence
chemical_list: D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D015415:Biomarkers; D002097:C-Reactive Protein