title: [Osteoporosis and inflammatory bowel disease: prevalence and risk factors in Tunisian patients].
abstract: OBJECTIVE
  The study was aimed to evaluate osteoporosis prevalence in a group of Tunisian patients with inflammatory bowel disease (IBD), to determine its risk factors, and to describe its mechanisms.
  
  
  METHODS
  We included 67 IBD patients, 43 patients with Crohn's disease (CD) and 24 with ulcerative colitis (UC). Bone mineral density was measured at the lumbar spine and left femoral neck by dual-energy X-ray absorptiometry. We used T score to express bone loss (osteopenia: -2.5 SD<T<- 1 SD, osteoporosis: T< -2.5 SD). Biochemical assessment of serum total alkaline phosphatases, osteocalcin, parathyroid hormone, vitamin D, interleukin-6, and urinary degradation products of C-telopeptide of type I collagen (CrossLaps), was also performed.
  
  
  RESULTS
  Prevalence of femoral osteoporosis was 31.8% and 13% in CD and UC patients, respectively and that of lumbar osteoporosis 40.9% and 8.7%, respectively. Femoral neck osteoporosis tended to be more frequent in CD (odds-ratios-OR=3.13 [95% CI: 0.79-12.5], P=0.09), in females (OR=2.20 [0.69-6.72], P=0,18) and in patients with active disease (OR=3.13 [0.94-10.00], P=0.06). Lumbar osteoporosis was significantly associated with CD (OR=7.14 [1.52-33.33], P<0.01). Low body mass index<20 kg/m2, disease course > 2 years and active disease tended to be associated with lumbar osteoporosis; the ORs were respectively 4.87 [0.92-25.80] (P=0.06), 4.21 [0.87-20.57] (P=0.06), and 2.33 [0.78-6.67] (P=0.13). No association was found with cumulated dose of steroids even when considering only CD. Patients with osteoporosis showed significant increased CrossLaps and interleukin-6 levels that indicate both high bone resorption and inflammatory activity.
  
  
  CONCLUSIONS
  Osteoporosis is frequent in IBD patients, especially in CD patients. Female gender, malnutrition (body mass index <20 kg/m2), disease course (> 2 years) and active disease would be risk factors of bone mineral loss in IBD. Osteoporosis is associated with enhanced bone resorption, that seems be linked to excessive intestinal inflammation.
authors: Service de Gastro-Entérologie A, Hôpital La Rabta, Tunis, Tunisie. jalel.boubaker@rns.tn
authors: Jalel
authors: J
authors: Boubaker
authors: Moncef
authors: M
authors: Feki
authors: Mohamed
authors: M
authors: Hsairi
authors: Monia
authors: M
authors: Fekih
authors: Neziha
authors: N
authors: Kaabachi
authors: Azza
authors: A
authors: Filali
authors: Abderraouf
authors: A
authors: Mebazaa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence; D012307:Risk Factors