title: Water-cooled, high-intensity ultrasound surgical applicators with frequency tracking.
abstract: High-intensity, focused ultrasound (HIFU) applicators have been developed for arresting bleeding with the ultimate intent of use in surgery. The design uses a tapered titanium component for transmission coupling of the ultrasound energy from a spherically curved transducer to biological tissues. The nominal operating frequency is 5.5 MHz, in a highly resonant mode (quality factor of 327 with water load). Liquid cooling is used to remove energy loss important at net applied power greater than 18 W/cm2 at the surface of the piezoelectric element. A downward resonance frequency shift (>20 kHz) occurs, even with cooling, as the applicator warms with normal operation. A feedback technique is used for maintaining the excitation near optimum resonance. Standing wave ratios of the applied power of 1.6 or less are thus sustained. The system and applicators have been found to be highly robust, effective in achieving hemostasis in the hemorrhaging liver, spleen, lung, or blood vessels in rabbit and pig experiments. One unit has been operated for over 1.7 hours in treating organ hemorrhage in blunt trauma experiments with nine swine with electrical net power of up to 158 W (31 W/cm2 across the transducer) and intensity of 2560 W/cm2 at focus.
authors: University of Washington, Seattle, WA 98195, USA. rmartin@apl.washington.edu
authors: Roy W
authors: RW
authors: Martin
authors: Shahram
authors: S
authors: Vaezy
authors: Andrew
authors: A
authors: Proctor
authors: Terrence
authors: T
authors: Myntti
authors: Janelle B J
authors: JB
authors: Lee
authors: Lawrence A
authors: LA
authors: Crum
mesh_terms: D000818:Animals; D003080:Cold Temperature; D003198:Computer Simulation; D004564:Electrocoagulation / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D005246:Feedback; D006470:Hemorrhage / Q000628:therapy*; D008954:Models, Biological; D011817:Rabbits; D013552:Swine; D014025:Titanium; D014159:Transducers; D014464:Ultrasonic Therapy / Q000295:instrumentation* / Q000379:methods; D014867:Water
chemical_list: D014867:Water; D014025:Titanium