Amphidinolide Y, a novel 17-membered macrolide from dinoflagellate Amphidinium sp.: plausible biogenetic precursor of amphidinolide X.
A novel cytotoxic 17-membered macrolide, amphidinolide Y (1), has been isolated from a marine dinoflagellate Amphidinium sp., and it was elucidated to exist as a 9:1 equilibrium mixture of 6-keto- and 6(9)-hemiacetal forms (1a and 1b, respectively) on the basis of 2D NMR data and chemical means. The feeding experiments with (13)C-labeled acetates suggested that amphidinolide Y (1) may be a biogenetic precursor of 16-membered macrodiolide, amphidinolide X (2).
Tsuda
Masashi
M
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Izui
Naoko
N
Shimbo
Kazutaka
K
Sato
Masaaki
M
Fukushi
Eri
E
Kawabata
Jun
J
Kobayashi
Jun'ichi
J
D000818:Animals; D004141:Dinoflagellida / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment; D000097442:Amphidinolides
D018942:Macrolides; C480942:amphidinolide X; D000097442:Amphidinolides; C482967:amphidinolide Y