Removal of gelatin from live vaccines and DTaP-an ultimate solution for vaccine-related gelatin allergy.
From the early 1990s infants started to receive acellular pertussis vaccine combined with diphtheria and tetanus toxoids (DTaP) before live vaccines such as measles, rubella, and mumps vaccines, which contained gelatin as a stabilizer. Then, an increasing number of cases of anaphylactic/allergic reactions to those live vaccines were reported. Almost all these cases had a previous history of receiving three or four doses of DTaP containing gelatin.Anaphylactic/allergic reactions to live measles vaccine were analyzed using information obtained from the Reporting System, a retrospective study, as well as from the Monitoring System, a prospective study. Dramatic decreases in anaphylactic/allergic reactions to live measles vaccines were observed immediately after each manufacturer marketed gelatin-free or gelatin (hypo-allergic)-containing live measles vaccine, and since the end of 1998 reports on anaphylactic/allergic reactions to live measles vaccine have almost ceased.
Kuno-Sakai
Harumi
H
Department of Public Health and Social Medicine, School of Medicine, Tokai University, 143 Shimokasuya, Isehara City, Kanagawa, 259-1193, Japan.
Kimura
Mikio
M
D000707:Anaphylaxis / Q000209:etiology / Q000517:prevention & control; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology / Q000302:isolation & purification*; D004342:Drug Hypersensitivity / Q000209:etiology / Q000517:prevention & control; D005780:Gelatin / Q000009:adverse effects* / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007564:Japan; D011446:Prospective Studies; D012189:Retrospective Studies
D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D005780:Gelatin