title: Pulmonary involvement in pediatric lymphoma.
abstract: BACKGROUND
  The prevalence of pulmonary lymphoma in the pediatric age group is not documented in the literature.
  
  
  OBJECTIVE
  This study was designed to assess the prevalence of pulmonary parenchymal lymphoma in children with Hodgkin disease (HD), non-Hodgkin lymphoma (NHL) and post-transplant lymphoproliferative disorder (PTLD).
  
  
  METHODS
  A 10-year retrospective analysis of 161 lymphoma patients (62 girls and 99 boys), mean age of 12.4 years, was performed. The definition of pulmonary lymphoma excluded those with isolated pleural disease and/or mediastinal adenopathy.
  
  
  RESULTS
  Eighty-two patients had HD, 65 had NHL, and 14 had PTLD. Overall prevalence of pulmonary parenchymal involvement was 13% (21/161), including 12% of patients with HD, 10% of patients with NHL, and 29% of patients with PTLD. CT findings included: pulmonary nodules (90%) or mass (38%); interstitial (9%) or alveolar (9%) disease; cavitation (9%); and pleural based mass (9%).
  
  
  CONCLUSIONS
  Pulmonary parenchymal disease in our pediatric lymphoma population was more prevalent than expected (13%). This is significant for patient management. New pulmonary lesions in patients with known lymphoma should be regarded with suspicion. In the setting of immune suppression, pulmonary lesions treated as infection may actually represent lymphoma. Expeditious biopsy of lesions failing to respond promptly to antibiotic therapy should be considered.
authors: Department of Radiology, University of Michigan Health Systems, 1500 E. Medical Center Drive/F3505, Ann Arbor, MI 48109-0030, USA.
authors: Katherine E
authors: KE
authors: Maturen
authors: Caroline E
authors: CE
authors: Blane
authors: Peter J
authors: PJ
authors: Strouse
authors: J Thomas
authors: JT
authors: Fitzgerald
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D008223:Lymphoma / Q000000981:diagnostic imaging*; D008232:Lymphoproliferative Disorders / Q000000981:diagnostic imaging*; D008297:Male; D013902:Radiography, Thoracic; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed