title: Synthesis of deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids.
abstract: Deuterated isotopomers of 7alpha- and (25R,S)-26-hydroxycholesterol, internal standards for in vivo determination of the two biosynthetic pathways of bile acids formation from cholesterol, were prepared from [2,2,3,4,4,6-2H(6)]-cholesterol and (20S)-[7,7,21,21-2H(4)]-3beta-(tert-butyldimethylsilyl)oxy-20-methylpregna-5-en-21-ol, respectively.
authors: Dipartimento di Scienze Precliniche LITA Vialba, Universitá degli Studi di Milano, Via G.B. Grassi, 74-20157, Milan, Italy.
authors: Pierangela
authors: P
authors: Ciuffreda
authors: Silvana
authors: S
authors: Casati
authors: Laura
authors: L
authors: Alessandrini
authors: Giancarlo
authors: G
authors: Terraneo
authors: Enzo
authors: E
authors: Santaniello
mesh_terms: D001647:Bile Acids and Salts / Q000378:metabolism*; D003903:Deuterium / Q000737:chemistry*; D006888:Hydroxycholesterols / Q000737:chemistry*; D007553:Isotope Labeling; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001647:Bile Acids and Salts; D006888:Hydroxycholesterols; C007042:cholest-5-ene-3 beta,26-diol; C011724:cholest-5-en-3 beta,7 alpha-diol; D003903:Deuterium