[Study on the total activity of PKC and the quantity of PKC (alpha, beta) in left auricle tissues of the patients with mitral disease and atrial fibrillation].
OBJECTIVE
To investigate the possible relation of atrial fibrillation (AF) with the total activity of protein kinase C (PKC) and the quantity of PKC (alpha, beta) in the left auricle tissues of the patients with mitral disease.


METHODS
Thirty-five patients hospitalized for valve replacement surgery were divided into four groups: group A (simple mitral stenosis with AF), group B(simple mitral stenosis with sinus rhythm), group C(simple mitral regurgitation with AF), group D (simple mitral regurgitation with sinus rhythm), The total PKC, activity and the quantity of PKC alpha and PKC beta were measured and compared in an attempt to find out whether significant difference exists between the groups.


RESULTS
There was no significant difference in total PKC activity between the four groups (P > 0.05). The quantity of PKC alpha in patients with AF was lower than that in patients with sinus rhythm, the quantity of PKC beta in patients with AF was higher than in patients with sinus rhythm. But these differences were not statistically significant (P > 0.05).


CONCLUSIONS
Under conditions of the same rhythm and the same heart disease, the total PKC activity and the quantity of PKC (alpha, beta) of the four groups showed no significant difference. No obvious relation was seen between the total activity of PKC in left auricle tissue and the occurrence of AF in patients with mitral disease, but more research on the relation between AF and the quantity of PKC isoforms in left auricle tissues would be needed.
Cao
Ge
G
Department of Cardiothoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
Xiao
Xijun
X
Xu
Yanhua
Y
Fu
Mingde
M
Nie
Liangming
L
D001281:Atrial Fibrillation / Q000201:enzymology* / Q000209:etiology; D006325:Heart Atria / Q000201:enzymology; D006801:Humans; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000201:enzymology*; D008946:Mitral Valve Stenosis / Q000150:complications / Q000201:enzymology*; D011493:Protein Kinase C / Q000032:analysis / Q000378:metabolism*; D064546:Protein Kinase C beta; D051571:Protein Kinase C-alpha
C496628:PRKCA protein, human; D011493:Protein Kinase C; D064546:Protein Kinase C beta; D051571:Protein Kinase C-alpha