Synthesis and biological evaluation of benzazepine oxazolidinone antibacterials.
Novel benzazepine oxazolidinone antibacterials were synthesized and evaluated against clinically relevant susceptible and resistant organisms. The effect of ring nitrogen position and N-substitution on antibacterial activity is examined.
Johnson
Paul D
PD
Discovery-Chemistry, Pharmacia Corporation, 7000 Portage Road, Kalamazoo, MI 49001, USA. paul.d.johnson@pharmacia.com
Aristoff
Paul A
PA
Zurenko
Gary E
GE
Schaadt
Ronda D
RD
Yagi
Betty H
BH
Ford
Charles W
CW
Hamel
Judith C
JC
Stapert
Douglas
D
Moerman
Judy K
JK
D000081:Acetamides / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001552:Benzazepines / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D000069349:Linezolid; D051379:Mice; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000081:Acetamides; D000900:Anti-Bacterial Agents; D001552:Benzazepines; D023303:Oxazolidinones; D000069349:Linezolid