Synthesis and biological activity of N-Acylated ornithine analogues of daptomycin.
N-Acylated ornithine analogues of daptomycin were synthesized and tested for their antibacterial efficacy.
Hill
Jason
J
Cubist Pharmaceuticals Inc., 65 Hayden Ave, Lexington, MA 02421, USA.
Siedlecki
James
J
Parr
Ian
I
Morytko
Michael
M
Yu
Xiang
X
Zhang
Yanzhi
Y
Silverman
Jared
J
Controneo
Nicole
N
Laganas
Valerie
V
Li
Tongchuan
T
Lai
Jan-Ji
JJ
Keith
Dennis
D
Shimer
George
G
Finn
John
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017576:Daptomycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D008826:Microbial Sensitivity Tests; D009952:Ornithine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D018805:Sepsis / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000472:pathogenicity
D000900:Anti-Bacterial Agents; D009952:Ornithine; D017576:Daptomycin