title: Reassessment of the pathways responsible for cerebrospinal fluid absorption in the neonate.
abstract: OBJECTIVE
  In neonatal lambs, the quantitative evidence suggests that a significant volume of cranial CSF drainage is associated with transport along olfactory nerves with absorption primarily into extracranial lymphatics in the paranasal region. Arachnoid granulations appear to be poorly developed at this level of development and their function is unknown. In this report, we tested whether a CSF protein tracer ((131)I-human serum albumin) could transport directly into the superior sagittal sinus of newborn lambs.
  
  
  RESULTS
  The concentration of the tracer administered into the CSF compartment was measured in the confluence of the intracranial venous sinuses (torcula) and in the peripheral blood (inferior vena cava). Enrichment of the CSF tracer in the cranial venous system was most evident when the CSF-venous sinus pressure gradients approached 20-30 cm H(2)O.
  
  
  CONCLUSIONS
  The data suggests that neonatal CSF can be absorbed directly into the cranial venous system. However, contrary to the classical view, this route may represent an auxiliary system that is recruited to compliment lymphatic transport when intracranial pressures are very high.
authors: Neuroscience Research, Department of Laboratory Medicine and Pathobiology, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
authors: C
authors: C
authors: Papaiconomou
authors: A
authors: A
authors: Zakharov
authors: N
authors: N
authors: Azizi
authors: J
authors: J
authors: Djenic
authors: M
authors: M
authors: Johnston
mesh_terms: D000042:Absorption / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D000831:Animals, Newborn; D001692:Biological Transport / Q000502:physiology; D002555:Cerebrospinal Fluid / Q000378:metabolism / Q000502:physiology*; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology; D005070:Evans Blue / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology; D007456:Iodine Isotopes / Q000378:metabolism; D008297:Male; D011897:Random Allocation; D044967:Serum / Q000378:metabolism; D012756:Sheep; D012826:Silicone Elastomers / Q000493:pharmacokinetics; D012850:Sinus of Valsalva / Q000502:physiology; D013997:Time Factors
chemical_list: D007456:Iodine Isotopes; D012826:Silicone Elastomers; D005070:Evans Blue