Evaluation of pulsatile and nonpulsatile flow in microvessels of the bulbar conjunctiva in the goat with an undulation pump artificial heart.
This study has three purposes, as follows. The first is to develop a microscopic system to observe the microcirculation of animals implanted with an artificial heart. The second is to investigate the influence of flow pattern change from pulsatile to nonpulsatile on the microcirculation. The third is to study the effects of pulsatility in blood flow on endothelium-derived nitric oxide release in the microvasculature. When the flow pattern was changed from pulsatile to nonpulsatile, the velocity of erythrocytes in many capillaries dropped and remained at a low level, and the number of perfused capillaries decreased. After the flow pattern was returned to pulsatile, the velocity of erythrocytes recovered to the initial level. In many cases, the flow of nonperfused capillaries recovered to the initial level as well. Also, the pulsatile flow enhances the basal and flow-stimulated endothelium-derived nitric oxide release in microvessels.
Baba
Atsushi
A
Department of Biomedical Engineering, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. atsushi@bme.rcast.u-tokyo.ac.jp
Dobsak
Petr
P
Mochizuki
Shuichi
S
Saito
Itsuro
I
Isoyama
Takashi
T
Takiura
Koki
K
Shibata
Masahiro
M
Abe
Yusuke
Y
Chinzei
Tsuneo
T
Vasku
Jaromir
J
Imachi
Kou
K
D000818:Animals; D005260:Female; D006041:Goats; D006354:Heart, Artificial; D006439:Hemodynamics; D008833:Microcirculation / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism*; D011673:Pulsatile Flow / Q000502:physiology*
D009569:Nitric Oxide