Screening of plant extracts for antiprotozoal and cytotoxic activities.
Methanolic and aqueous extracts derived from 43 plant species, selected either from ethnobotanical or chemotaxonomical data, were screened for their antiprotozoal activity against Leishmania donovani and Trypanosoma brucei brucei. The cytotoxic activity against KB cells was also determined. Eight extracts had IC50 values of less than 10 microg/ml against Leishmania donovani. The most active was Triclisia patens with an IC50 value of 1.5 microg/ml against Leishmania donovani. Annona purpurea and Alstonia macrophylla had IC50 values below 10 microg/ml against Trypanosoma brucei brucei. Annona purpurea was the most cytotoxic against KB cells.
Camacho
M d R
Md
Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK. mrayocamacho@yahoo.com.mx
Phillipson
J D
JD
Croft
S L
SL
Solis
P N
PN
Marshall
S J
SJ
Ghazanfar
S A
SA
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D006801:Humans; D007624:KB Cells; D007893:Leishmania donovani / Q000187:drug effects; D000432:Methanol / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal; D014346:Trypanosoma brucei brucei / Q000187:drug effects; D014867:Water / Q000737:chemistry
D000970:Antineoplastic Agents; D000981:Antiprotozoal Agents; D010936:Plant Extracts; D014867:Water; D000432:Methanol