title: Age affects severity of venous gas emboli on decompression from 14.7 to 4.3 psia.
abstract: BACKGROUND
  Variables that define who we are, such as age, weight and fitness level influence the risk of decompression sickness (DCS) and venous gas emboli (VGE) from diving and aviation decompressions. We focus on age since astronauts that perform space walks are approximately 10 yr older than our test subjects. Our null hypothesis is that age is not statistically associated with the VGE outcomes from decompression to 4.3 psia.
  
  
  METHODS
  Our data are from 7 different NASA tests where 188 men and 50 women performed light exercise at 4.3 psia for planned exposures no less than 4 h. Prebreathe (PB) time on 100% oxygen ranged from 150-270 min, including ascent time, with exercise of different intensity and length being performed during the PB in four of the seven tests with 150 min of PB. Subjects were monitored for VGE in the pulmonary artery using a Doppler ultrasound bubble detector for a 4-min period every 12 min. There were six design variables; the presence or absence of lower body adynamia and five PB variables; plus five concomitant variables on physical characteristics: age, weight height, body mass index, and gender that were available for logistic regression (LR). We used LR models for the probability of DCS and VGE, and multinomial logit (ML) models for the probability of Spencer VGE Grades 0-IV at exposure times of 61, 95, 131, 183 min, and for the entire exposure.
  
  
  RESULTS
  Age was significantly associated with VGE in both the LR and ML models, so we reject the null hypothesis. Lower body adynamia was significant for all responses.
  
  
  CONCLUSIONS
  Our selection of tests produced a wide range of the explanatory variables, but only age, lower body adynamia, height, and total PB time was helpful in various combinations to model the probability of DCS and VGE.
authors: Human Adaptations and Countermeasures Office, Environmental Physiology Laboratory, NASA/Johnson Space Center, Houston, TX 77058-3696, USA. jconkin@ems.jsc.nasa.gov
authors: Johnny
authors: J
authors: Conkin
authors: Michael R
authors: MR
authors: Powell
authors: Michael L
authors: ML
authors: Gernhardt
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003664:Decompression / Q000009:adverse effects*; D003665:Decompression Sickness / Q000150:complications* / Q000503:physiopathology; D004618:Embolism, Air / Q000209:etiology* / Q000503:physiopathology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000503:physiopathology*; D012307:Risk Factors