title: Association of depression, CD8+ T lymphocytes, and natural killer cell activity: implications for morbidity and mortality in Human immunodeficiency virus disease.
abstract: A heightened risk of mood disorders, such as major depression, and acute depressive symptoms has been observed among HIV-seropositive individuals since the start of the AIDS epidemic, and an accumulating body of data now shows that depression may have an impact on morbidity and mortality among individuals with HIV disease. Although the specific physiologic mechanisms involved in this process have not been delineated, there is some evidence to suggest that certain components of innate immunity, including killer lymphocytes such as CD8+ T lymphocytes and natural killer cells, may represent key pathways through which depression affects HIV disease progression. This paper reviews some of the main studies examining the effects of depression on immunity and HIV disease progression and discusses the potential role of killer lymphocytes as an underlying mechanism by which depression may impact morbidity and mortality.
authors: Department of Psychology, University of Pennsylvania, 3815 Walnut Street, Philadelphia, PA 19104, USA. dcruess@psych.upenn.edu
authors: Dean G
authors: DG
authors: Cruess
authors: Steven D
authors: SD
authors: Douglas
authors: John M
authors: JM
authors: Petitto
authors: Jane
authors: J
authors: Leserman
authors: Thomas
authors: T
authors: Ten Have
authors: David
authors: D
authors: Gettes
authors: Benoit
authors: B
authors: Dubé
authors: Dwight L
authors: DL
authors: Evans
mesh_terms: D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D015897:Comorbidity; D003863:Depression / Q000276:immunology* / Q000401:mortality; D003865:Major Depressive Disorder / Q000276:immunology* / Q000401:mortality; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000401:mortality; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D018655:Lymphocyte Count; D008297:Male; D011598:Psychoneuroimmunology; D012306:Risk; D015996:Survival Rate