title: Metformin-associated lactic acidosis and acute renal failure in a type 2 diabetic patient.
abstract: Metformin belongs to a class of drugs known as the biguanides that are widely used in the treatment of type 2 diabetes mellitus. Its association with lactic acidosis is well established, although rare. Metformin-associated lactic acidosis is recognized as a potentially lethal condition that can occur in patients with contraindications to the drug, such as renal dysfunction, liver diseases, alcoholism, and cardiopulmonary diseases. In these cases, the plasma concentration of metformin is not necessarily abnormally high. We describe a 75-year-old diabetic woman with acute renal failure and life-threatening lactic acidosis due to metformin intoxication. Clinical manifestations included vomiting, diarrhea, hypothermia, hypotension and transitory blindness. Her initial renal function was recovered after hemodialysis and she was discharged 3 months after admission.
authors: Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
authors: Chen-Kuo
authors: CK
authors: Chu
authors: Yao-Tien
authors: YT
authors: Chang
authors: Bor-Jen
authors: BJ
authors: Lee
authors: Sung-Yuan
authors: SY
authors: Hu
authors: Wei-Hsiung
authors: WH
authors: Hu
authors: Dar-Yu
authors: DY
authors: Yang
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced*; D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008687:Metformin / Q000009:adverse effects*
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin