Association of MICA polymorphism with rheumatoid arthritis patients in Koreans.
To investigate whether genetic variations of MICA are associated with susceptibility to rheumatoid arthritis (RA), the (GCT)n microsatellite polymorphism of the transmembrane domain was analyzed in 144 Korean patients with RA and in 297 unrelated healthy controls. The allele frequency of MICA*A9 significantly decreased in RA patients compared with controls (9.0% vs. 15.3%, odds ratio [OR] = 0.55, p = 0.0098, p(c) = 0.049), whereas the frequency of the MICA*A4 and MICA*A5.1 alleles tended to increase in RA patients (21.2% vs. 14.8%, OR = 1.55, p = 0.018, p(c) > 0.05; 20.5% vs. 15.0%, OR = 1.46, p = 0.0403, p(c) > 0.05). By subgroup analysis, the MICA*A4 allele significantly increased in seropositive RA patients versus controls (23.0% vs. 14.8%, OR = 1.69, p = 0.0082, p(c) = 0.041). HLA-DRB1*0405 was strongly associated with RA (p(c) = 0.0000008), and strong linkage disequilibrium was observed between HLA-DRB1*0405 and MICA*A4 alleles in controls (p(c) = 0.000004) as well as in RA patients (p(c) = 0.0012). In Korean patients, HLA-DRB1*0405 was primarily associated with RA and the weak association of RA with MICA*A4 was secondary to that with HLA-DRB1*0405. Additionally, MICA*A9 might have a weak protective effect on the susceptibility to RA in Koreans.
Mok
Jee Won
JW
Department of Biology, Sungshin Women's University, Seoul, South Korea.
Lee
Yun Jong
YJ
Kim
Jeong Yeon
JY
Lee
Eun Bong
EB
Song
Yeong Wook
YW
Park
Myoung Hee
MH
Park
Kyung Sook
KS
D000293:Adolescent; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology; D002648:Child; D015395:Histocompatibility Antigens Class I / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007723:Korea; D015810:Linkage Disequilibrium; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*
D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A