title: Use of NSE/PS2m-transgenic mice in the study of the protective effect of exercise on Alzheimer's disease.
abstract: In its late stage, Alzheimer's disease results in progressive muscle weakness in the arms and legs. The aim of this study was to determine whether mice expressing the skeletal muscle-specific mutant PS2 gene (a model of Alzheimer's disease) are a useful experimental system to study the protective effect of exercise on A beta-42 reduction, improvement of behavioural function and changes in metabolic parameters. With this aim in mind, the transgenic mice were subjected to treadmill exercise for 3 months. The results showed that in transgenic mice, but not in normal mice, treadmill exercise resulted in a reduction of A beta-42 deposits and an improvement in behavioural function, thereby restoring normal concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride. Thus, exercise may represent a practical therapeutic strategy for use with human patients with Alzheimer's disease.
authors: Division of Laboratory Animal Resources, National Institute of Toxicological Research, Korea FDA, Seoul 122-704, Korea.
authors: Jun Y
authors: JY
authors: Cho
authors: Dae Y
authors: DY
authors: Hwang
authors: Tae S
authors: TS
authors: Kang
authors: Dong H
authors: DH
authors: Shin
authors: Jin H
authors: JH
authors: Hwang
authors: Chae H
authors: CH
authors: Lim
authors: Su H
authors: SH
authors: Lee
authors: Hwa J
authors: HJ
authors: Lim
authors: Sae H
authors: SH
authors: Min
authors: Su J
authors: SJ
authors: Seo
authors: Youn S
authors: YS
authors: Song
authors: Ki T
authors: KT
authors: Nam
authors: Kyu S
authors: KS
authors: Lee
authors: Jung S
authors: JS
authors: Cho
authors: Yong K
authors: YK
authors: Kim
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D018482:Muscle, Skeletal / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000235:genetics*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D053766:Presenilin-2; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008565:Membrane Proteins; C508861:PSEN2 protein, human; D053766:Presenilin-2; D014280:Triglycerides; D002784:Cholesterol; D010751:Phosphopyruvate Hydratase