Glancing behind virus load variation in HIV-1 infection.
Although the steady-state virus load during HIV-1 infection is remarkably stable within a patient, it displays variation over several orders of magnitude between patients. Despite intensive research, the host and virus factors that are responsible for the observed variation remain poorly understood. Comparison of model predictions with clinical data suggests that most of the variation in steady-state virus load between patients reflects variation of the net rate at which activated CD4 cells are produced.
Bonhoeffer
Sebastian
S
Ecology & Evolution, ETH Zürich, ETH Zentrum NW, CH-8092 Zürich, Switzerland. Bonhoeffer@eco.umnw.ethz.ch
Funk
Georg A
GA
Günthard
Huldrych F
HF
Fischer
Marek
M
Müller
Viktor
V
D014644:Genetic Variation; D015658:HIV Infections / Q000276:immunology / Q000382:microbiology / Q000821:virology*; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D019562:Viral Load; D014779:Virus Replication