Dietary intake and risk of persistent human papillomavirus (HPV) infection: the Ludwig-McGill HPV Natural History Study.
The association between dietary intake and persistence of type-specific human papillomavirus (HPV) infection, during a 12-month period, among 433 women participating in the Ludwig-McGill HPV Natural History Study was evaluated by use of a nested case-control design. Dietary intake was assessed by a food-frequency questionnaire at the month-4 visit. HPV status was assessed at months 0, 4, 8, and 12 by polymerase chain reaction (MY09/11). Only women who ever tested positive for HPV were included in the present study: 248 had transient HPV infections (1 of 4 positive tests or nonconsecutively positive), and 185 had persistent HPV infections (> or =2 consecutive tests positive for the same HPV type). Risk of type-specific, persistent HPV infection was lower among women reporting intake values of beta-cryptoxanthin and lutein/zeaxanthin in the upper 2 quartiles and intake values of vitamin C in the upper quartile, compared with those reporting intake in the lowest quartile. Consumption of papaya > or =1 time/week was inversely associated with persistent HPV infection.
Giuliano
Anna R
AR
University of Arizona Cancer Center and College of Public Health, Tucson, Arizona 85724-5024, USA. agiuliano@azcc.arizona.edu.
Siegel
Erin M
EM
Roe
Denise J
DJ
Ferreira
Silvandeiede
S
Baggio
Maria Luiza
ML
Galan
Lenice
L
Duarte-Franco
Eliane
E
Villa
Luisa L
LL
Rohan
Thomas E
TE
Marshall
James R
JR
Franco
Eduardo L
EL
D000328:Adult; D001205:Ascorbic Acid / Q000378:metabolism; D001938:Brazil; D016022:Case-Control Studies; D015331:Cohort Studies; D065366:Cryptoxanthins; D005247:Feeding Behavior; D005260:Female; D005638:Fruit / Q000378:metabolism; D006801:Humans; D008137:Longitudinal Studies; D014975:Lutein / Q000097:blood; D009752:Nutritional Status / Q000502:physiology*; D027383:Papillomaviridae / Q000254:growth & development*; D030361:Papillomavirus Infections / Q000209:etiology*; D011203:Poverty; D011795:Surveys and Questionnaires; D014412:Tumor Virus Infections / Q000209:etiology*; D014505:Urban Population; D024341:Xanthophylls; D019207:beta Carotene / Q000031:analogs & derivatives* / Q000097:blood
D065366:Cryptoxanthins; D024341:Xanthophylls; D019207:beta Carotene; D001205:Ascorbic Acid; D014975:Lutein