title: Predisposition locus for major depression at chromosome 12q22-12q23.2.
abstract: Major depression disorder is a common psychiatric disease with a major economic impact on society. In many cases, no effective treatment is available. The etiology of major depression is complex, but it is clear that the disease is, to a large extent, determined genetically, especially among individuals with a familial history of major depression, presumably through the involvement of multiple predisposition genes in addition to an environmental component. As a first step toward identification of chromosomal loci contributing to genetic predisposition to major depression, we have conducted a genomewide scan by using 628 microsatellite markers on 1,890 individuals from 110 Utah pedigrees with a strong family history of major depression. We identified significant linkage to major depression in males at marker D12S1300 (multipoint heterogeneity LOD score 4.6; P=.00003 after adjustment for multiple testing). With additional markers, the linkage evidence became highly significant, with the multipoint heterogeneity LOD score at marker D12S1706 increasing to 6.1 (P=.0000007 after adjustment for multiple testing). This study confirms the presence of one or more genes involved in psychiatric diseases on the q arm of chromosome 12 and provides strong evidence for the existence of a sex-specific predisposition gene to major depression at 12q22-q23.2.
authors: Myriad Genetics, Salt Lake City, UT, 84108, USA. victor@myriad.com
authors: Victor
authors: V
authors: Abkevich
authors: Nicola J
authors: NJ
authors: Camp
authors: Charles H
authors: CH
authors: Hensel
authors: Chris D
authors: CD
authors: Neff
authors: Deanna L
authors: DL
authors: Russell
authors: Dana C
authors: DC
authors: Hughes
authors: Agnes M
authors: AM
authors: Plenk
authors: Michael R
authors: MR
authors: Lowry
authors: R Lynn
authors: RL
authors: Richards
authors: Catherine
authors: C
authors: Carter
authors: Georges C
authors: GC
authors: Frech
authors: Steven
authors: S
authors: Stone
authors: Kerry
authors: K
authors: Rowe
authors: Chi Ai
authors: CA
authors: Chau
authors: Kathleen
authors: K
authors: Cortado
authors: Angelene
authors: A
authors: Hunt
authors: Karanina
authors: K
authors: Luce
authors: Gayanne
authors: G
authors: O'Neil
authors: Jeff
authors: J
authors: Poarch
authors: Jennifer
authors: J
authors: Potter
authors: Gregg H
authors: GH
authors: Poulsen
authors: Heidi
authors: H
authors: Saxton
authors: Michelle
authors: M
authors: Bernat-Sestak
authors: Victor
authors: V
authors: Thompson
authors: Alexander
authors: A
authors: Gutin
authors: Mark H
authors: MH
authors: Skolnick
authors: Donna
authors: D
authors: Shattuck
authors: Lisa
authors: L
authors: Cannon-Albright
mesh_terms: D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics*; D003865:Major Depressive Disorder / Q000235:genetics*; D008040:Genetic Linkage / Q000235:genetics*; D005820:Genetic Testing; D015894:Genome, Human; D006801:Humans; D018895:Microsatellite Repeats / Q000235:genetics; D010375:Pedigree; D014589:Utah