Biodegradable poly(ether-ester) multiblock copolymers for controlled release applications.
Multiblock poly(ether-ester)s based on poly(ethylene glycol), butylene terephthalate, and butylene succinate units were synthesized by a two-step melt polycondensation reaction, with the aim of developing a new series of degradable polymers for controlled release applications. The copolymers were characterized with respect to their composition (NMR), thermal properties (DSC), and swelling. The main focus was on the degradation kinetics and release properties of the copolymers. The crystallinity and swelling could be tailored by the PEG segment length and the ratio of the building units. With increasing mol fraction succinate in the hard segment, the swelling increased. The in vitro degradation was found to occur by molecular weight decrease and mass loss. Substitution of the aromatic terephthalate units by aliphatic succinate units increased the degradation rate of the copolymers. Polymers with PEG segments of 1000 kg/mol showed a more pronounced degradation than copolymers containing shorter and longer PEG segments. Model proteins were successfully incorporated and released from the poly(ether-ester) films. Depending on the size of the protein, the release mechanism was based on diffusion of the protein and degradation of the matrix.
van Dijkhuizen-Radersma
R
R
Chienna B.V., Prof. Bronkhorstlaan 10-D, 3723 MB Bilthoven, The Netherlands. riemke.van.dijkhuizen@chienna.com
Roosma
J R
JR
Kaim
P
P
Métairie
S
S
Péters
F L A M A
FL
de Wijn
J
J
Zijlstra
P G
PG
de Groot
K
K
Bezemer
J M
JM
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D004987:Ethers / Q000737:chemistry* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D008970:Molecular Weight; D011091:Polyesters / Q000737:chemistry* / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D013386:Succinates / Q000737:chemistry; D013696:Temperature
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004987:Ethers; D011091:Polyesters; D011108:Polymers; D011506:Proteins; D013386:Succinates; D011092:Polyethylene Glycols