Treatment of grade III anal intraepithelial neoplasia with photodynamic therapy: report of a case.
OBJECTIVE
We report the use of photodynamic therapy to treat a 53-year-old female with Grade III anal intraepithelial neoplasia.


METHODS
Topical 5-aminolevulinic acid cream was applied to the affected area five hours before light treatment. The distribution of 5-aminolevulinic acid-induced protoporphyrin IX was identified by its characteristic red fluorescence. The lesion was treated by illumination with a 630-nm red laser light that used a total energy of 125 J/cm2 for approximately 17 minutes.


RESULTS
Complete symptomatic relief was achieved after the first photodynamic therapy session, and macroscopic and microscopic ablation of dysplasia was achieved after a second session of photodynamic therapy. Healing was excellent, with no residual scarring or functional loss.


CONCLUSIONS
Photodynamic therapy offers a simple, noninvasive method for treatment of anal intraepithelial neoplasia.
Hamdan
Khaled A
KA
Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, Dundee, United Kingdom.
Tait
Iain S
IS
Nadeau
Valerie
V
Padgett
Miles
M
Carey
Frank
F
Steele
Robert J
RJ
D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D001005:Anus Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002278:Carcinoma in Situ / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D016896:Treatment Outcome
D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid