Evaluation of myocardial blood flow reserve in patients with chronic congestive heart failure due to idiopathic dilated cardiomyopathy.
This study demonstrates a significant impairment in coronary blood flow reserve in most patients with idiopathic dilated cardiomyopathy despite normal epicardial coronary arteries. This change may prevent appropriate increases in coronary blood flow and thus lead to myocardial ischemia and progression of disease. An association between decreased response to adenosine and acetylcholine supports previous observations indicating that adenosine-induced vasodilation of coronary microcirculation is dependent on endothelial nitric oxide production.
Canetti
Menahem
M
Heart Failure Program, Division of Cardiology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Akhter
Mohammed W
MW
Lerman
Amir
A
Karaalp
Ilyas S
IS
Zell
Jason A
JA
Singh
Harpreet
H
Mehra
Anilkumar
A
Elkayam
Uri
U
D000328:Adult; D001810:Blood Volume / Q000502:physiology; D002311:Cardiomyopathy, Dilated / Q000150:complications* / Q000000981:diagnostic imaging; D002908:Chronic Disease; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology*; D010496:Pericardium / Q000000981:diagnostic imaging / Q000503:physiopathology; D012720:Severity of Illness Index