Simplified serological diagnosis of endocarditis due to Coxiella burnetii and Bartonella.
We tested a single-step serological assay against Coxiella burnetii and Bartonella species and found a sensitivity of 100%, and a positive predictive value of 98% for the diagnosis of blood culture-negative endocarditis (BCNE). This assay should be considered as a possible commercial test for the diagnosis of BCNE.
Rolain
J M
JM
Unité des Rickettsies, CNRS UMR 6020, Faculté de Médecine, Université de la Méditerranée, 13385 Marseille Cedex 05, France.
Lecam
C
C
Raoult
D
D
D000907:Antibodies, Bacterial / Q000097:blood; D001473:Bartonella / Q000276:immunology* / Q000302:isolation & purification; D016022:Case-Control Studies; D016997:Coxiella burnetii / Q000276:immunology* / Q000302:isolation & purification; D003429:Cross Reactions / Q000276:immunology; D004696:Endocarditis / Q000209:etiology / Q000382:microbiology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D011237:Predictive Value of Tests; D011778:Q Fever / Q000175:diagnosis / Q000382:microbiology; D012680:Sensitivity and Specificity; D012698:Serologic Tests / Q000379:methods / Q000592:standards
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G