Cognitive conditions of pathologically confirmed dementia with Lewy bodies and Parkinson's disease with dementia.
The relationship between dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) has been insufficiently described, and it is still problematic. Twenty-nine cases of DLB and 10 cases of PDD were investigated in the present study. DLB cases disclosed a significantly older disease onset and shorter disease duration than PDD cases (p<0.01 each). However, they showed no significant difference in dementia onset or dementia duration (p>0.05 each). Motor symptoms (parkinsonism) were suspected as the cause of the younger disease onset in PDD cases. Compared with 10 age-matched cases of definite Alzheimer's disease, both 19 DLB cases and 6 PDD cases had significantly better scores in the final test of mini-mental state examination (MMSE) and revised version of Hasegawa's Dementia Scale (HDSR) within 12 months before death, although no significant differences between DLB and PDD were indicated. DLB and PDD were suspected to show cognitive impairment of similar severity in the terminal stage. They would thus be difficult to classify as completely different entities.
Horimoto
Yoshihiko
Y
Choju Medical Institute, Fukushimura Hospital, Toyohashi, Aichi 441-8124, Japan. holly@hosp.midori.nagoya.jp
Matsumoto
Mitsuhiro
M
Nakazawa
Hideka
H
Yuasa
Hiroyuki
H
Morishita
Manabu
M
Akatsu
Hiroyasu
H
Ikari
Hiroyuki
H
Yamamoto
Takayuki
T
Kosaka
Kenji
K
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology / Q000523:psychology*; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000473:pathology / Q000503:physiopathology / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology / Q000523:psychology*