Analogs of RGDVY and GRGD peptides inhibit Mycobacterium kansasii phagocytosis.
Continuing our research on Mycobacteria kansasii phagocytosis inhibition, we have examined in that context three series of peptides derived from the RGDVY and GRGD sequences. It was found that the levels of the inhibitory activity depend on the amino acid composition as well as on the particular peptide sequence. Distinct inhibitory activity was found in the case of thymopentin (RKDVY), the active fragment of thymopoietin. In this case the Mycobacterium phagocytosis inhibition should be combined with general immunostimulatory activity of RKDVY peptide. Our examination of a series of GRGDV analogs with a successively prolonged oligo-Gly linker inserted into the peptide chain showed that the distance between the Arg and Asp residues required for such an activity should be about 9A.
Siemion
Ignacy Z
IZ
Institute of Chemistry, University of Wroclaw, Joliot-Curie 14, 50-383, Wroclaw, Poland. siemion@wchuwr.chem.uni.wroc.pl
Gawlowska
Monika
M
Krajewski
Krzysztof
K
Strug
Iwona
I
Wieczorek
Zbigniew
Z
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006790:Host-Parasite Interactions / Q000187:drug effects; D006801:Humans; D007962:Leukocytes / Q000187:drug effects; D051379:Mice; D019909:Mycobacterium kansasii / Q000187:drug effects*; D009842:Oligopeptides / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D009842:Oligopeptides; C064597:glycyl-arginyl-glycyl-aspartic acid