Perfusion of rabbit hearts with human blood results in immediate graft thrombosis, a temporally distinct component of hyperacute rejection.
Hyperacute discordant xenograft rejection can be simulated by a blood-perfused working isolated heart. The survival of the heart is dependent on its functional integrity, and the preparation is thus sensitive to early myocardial damage. Perfusion of rabbit hearts with human blood produces immediate graft destruction by a thrombotic process which is a distinct component of hyperacute rejection.
Forty
J
J
Papworth Hospital, Cambridge, UK.
Hasan
R
R
Cary
N
N
White
D J
DJ
Wallwork
J
J
D000208:Acute Disease; D000818:Animals; D003328:Coronary Thrombosis / Q000209:etiology; D016027:Heart Transplantation / Q000009:adverse effects / Q000473:pathology*; D006801:Humans; D010477:Perfusion; D011817:Rabbits; D014183:Transplantation, Heterologous / Q000473:pathology*