[GPIIB/IIIA blockade after high-risk angioplasty: new perspectives].
The treatment of acute coronary syndromes knows today revolution, with the clinical use of platelet glycoprotein IIb/IIIa inhibitors. The benefit of these agents as adjunctive treatment for percutaneous coronary intervention has been substantial and consistently proved among trials; however patients undergoing revascularization after drug discontinuation demonstrated a moderate event reduction. In this analysis, including the entire large-scale trial experience of intravenous glycoprotein IIb/IIIa inhibitors, we try to evaluate this therapeutic class in the high risk coronary intervention, in patients with acute coronary syndromes primarily medically managed, and in combination therapy with thrombolytics in the acute myocardial infarction. The purpose was to demonstrate the reduction of cardiac events after administration of this drug in the different indications and to precise their different adverse effects.
Smiri
Zahreddine
Z
Service de Cardiologie, Hôpital Militaire Principal d'Instruction de Tunis.
Lahidheb
Dhaker
D
Hajlaoui
Néjib
N
Barakett
Nadia
N
Rahal
Néjib
N
Azzouzi
Foued
F
Fehri
Wafa
W
Mhenni
Hédi
H
Haouala
Habib
H
D015906:Angioplasty, Balloon, Coronary; D003327:Coronary Disease / Q000628:therapy; D006801:Humans; D009203:Myocardial Infarction / Q000628:therapy; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*
D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex