[The distribution of individual radiation doses in liquidators of Chernobyl accident using cytogenetic analysis].
The cytogenetic screening was carried out in 100 Chernobyl clean-up workers (liquidators) with registered doses during 1 year after exposure. The bayesian analysis has been applied for constructing the individual distribution of probability density for biological doses estimated from dicentric and centric ring yields in liquidators. The coincidence of the biological and registered dose has been found in 25% of cases; among the rest persons the documented doses exceeded the biological estimations in 25% of cases and the cytogenetic doses were higher than registered ones in 50% of cases. The total distribution of biological doses was constructed by pooling the individual data in 50 mGy dose intervals. The distribution obtained had the maximum at 300-350 mGy and contained 68% of probability density in the dose range 0-1000 mGy. The probabilistic approach in cohort biodosimetry showed the necessity of corrections in radiogenic risk assessment for Chernobyl liquidators. The advantages of bayesian technique for biodosimetrical treatment of cytogenetic data in conditions of small number of cells scored and low aberration yields induced by low dose irradiation were discussed.
Maznik
N A
NA
Institute of Medical Radiology, Academy of Medical Sciences of Ukraine, Kharkiv, 61024 Ukraine. imr@online.kharkiv.net
Vinnikov
V A
VA
Maznik
V S
VS
D000328:Adult; D001499:Bayes Theorem; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000473:pathology / Q000528:radiation effects*; D008875:Middle Aged; D016273:Occupational Exposure / Q000032:analysis*; D011829:Radiation Dosage; D018788:Radioactive Hazard Release; D012189:Retrospective Studies; D014455:Ukraine