title: [Improved method of fluvoxamine synthesis].
abstract: To modify the synthetic method of fluvoxamine.
  
  
  
  Fluvoxamine was synthesized from 4-trifluoromethylbenzonitrile by the steps of Grignard reaction, hydrolysis and oximation.
  
  
  
  The chemical structure of the synthesized product was confirmed by (1)HNMR, and the total yield reached to 36.16%.
  
  
  
  The results indicate that the synthetic route is practical.
authors: College of Pharmaceutical Sciences  Zhejiang University, Hangzhou 310031 China.
authors: Tao
authors: T
authors: Liu
authors: Rong
authors: R
authors: Sheng
authors: Yong-zhou
authors: YZ
authors: Hu
mesh_terms: D016666:Fluvoxamine / Q000138:chemical synthesis*; D017367:Selective Serotonin Reuptake Inhibitors / Q000138:chemical synthesis*
chemical_list: D016666:Fluvoxamine; D017367:Selective Serotonin Reuptake Inhibitors