Oral isotretinoin: an analysis of its utilization in a managed care organization.
OBJECTIVE
To assess utilization of oral isotretinoin within a managed care organization.


METHODS
A retrospective analysis of pharmacy and medical claims from a southern California HMO was performed to (1) determine the prescribing patterns of oral isotretinoin from 1997 to 2000, stratified by age and gender, (2) categorize and quantify the use of antiacne prescriptions in the 6-month period immediately prior to the first oral isotretinoin prescription claim observed during this study; and (3) identify the amount of oral isotretinoin dispensed in a 210-day period following the dispensing date of the first oral isotretinoin prescription.


RESULTS
The number of prescriptions was distributed almost equally between males and females, and the average number of prescriptions dispensed per patient decreased with age. A total of 39% of patients who received an oral isotretinoin prescription had not received a prescription for any antiacne medication in the preceding 6 months, and an additional 31% had not received a prescription for a topical retinoid. Approximately 27% of patients received more than a 150-day supply within the 210-day period following the first oral isotretinoin claim.


CONCLUSIONS
These data suggest that in the 6 months preceding the first observed oral isotretinoin prescription, up to 70% of patients had not received a trial of a topical retinoid before receiving oral isotretinoin even though the product labeling advises that oral isotretinoin should be used only in patients unresponsive to.conventional therapy. (which is generally defined as at least a topical retinoid plus an oral antibiotic). Up to 27% of patients appeared to continue a course of treatment for longer than the 15-20 weeks advised in the isotretinoin product labeling.
Chen
Kristina
K
Pharmacoeconomics and Health Outcomes Research, Prescription Solutions, Costa Mesa, CA 92626, USA. kristina.chen@rxsol.com
White
T Jeffrey
TJ
Juzba
Michael
M
Chang
Eunice
E