A case of chronic renal dysfunction following treatment with oral acyclovir.
Nephrotoxicity is a well-known side effect of intravenous acyclovir treatment but occurs rarely by oral treatment. A 76-y-old healthy male, with normal baseline renal functions (blood creatinine 0.6 mg%), received oral acyclovir at a dose of 800 mg five times daily for 10 days for treatment of herpes zoster ophthalmicus. He developed renal failure with blood creatinine levels of 3 mg% and his renal function failed to improve within eight months of end of treatment. Affection of renal function has to be considered also in relation to oral acyclovir treatment, especially in elderly subjects.
Sodhi
Punita Kumari
PK
Department of Ophthalmology, Safdarjung Hospital, New Delhi, India. hardeep333@hotmail.com
Ratan
Simmi K
SK
D000212:Acyclovir / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000284:Administration, Oral; D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D006563:Herpes Zoster Ophthalmicus / Q000188:drug therapy; D006801:Humans; D007676:Kidney Failure, Chronic / Q000139:chemically induced*; D008297:Male
D000998:Antiviral Agents; D003404:Creatinine; D000212:Acyclovir