title: Intrauterine undernutrition--renal and vascular origin of hypertension.
abstract: A large number of clinical and experimental studies supports the hypothesis that intrauterine undernutrition is an important determinant of hypertension, coronary heart disease and non-insulin-dependent diabetes in the adult offspring. In this review, the renal and vascular repercussions of maternal undernutrition are emphasized, and the physiopatologic mechanisms discussed. The origin of hypertension is detailed based upon the findings of kidney functional parameters and endothelium function studies. A working model linking hypertension to intrauterine undernutrition is proposed.
authors: Departamento de Farmacologia, Instituto de Ciências Biomédicas I (ICB-I), Universidade de São Paulo, 05508-900, Av Prof Lineu Prestes, 1524, sala 205, São Paulo, SP, Brazil. mdcfranco@yahoo.com
authors: Maria
authors: M
authors: do Carmo Pinho Franco
authors: Dorothy
authors: D
authors: Nigro
authors: Zuleica B
authors: ZB
authors: Fortes
authors: Rita C A
authors: RC
authors: Tostes
authors: Maria Helena C
authors: MH
authors: Carvalho
authors: Sandra Regina Rodrigues
authors: SR
authors: Lucas
authors: Guiomar Nascimento
authors: GN
authors: Gomes
authors: Terezila Machado
authors: TM
authors: Coimbra
authors: Frida Zaladek
authors: FZ
authors: Gil
mesh_terms: D000818:Animals; D001120:Arginine / Q000378:metabolism; D001682:Biological Availability; D005314:Embryonic and Fetal Development; D004730:Endothelium, Vascular / Q000503:physiopathology; D004967:Estrogens / Q000378:metabolism; D005260:Female; D005317:Fetal Growth Retardation / Q000150:complications*; D005783:Gender Identity; D005865:Gestational Age; D005938:Glucocorticoids / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D007668:Kidney / Q000196:embryology / Q000503:physiopathology; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D009569:Nitric Oxide / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D014666:Vasomotor System / Q000502:physiology
chemical_list: D004967:Estrogens; D005938:Glucocorticoids; D009569:Nitric Oxide; D001120:Arginine