Leukocyte CD15 expression and platelet activation in the coronary sinus after coronary intervention.
Markers associated with coronary restenosis must be identified to develop therapeutic strategies for improving the clinical outcome. We studied whether adhesion proteins on leukocytes and platelets from coronary sinus blood were associated with restenosis after coronary intervention in patients with stable coronary artery disease. Adhesion proteins on platelets and leukocytes were measured by flow cytometry. Pre- and postinterventional leukocyte CD15 expression was significantly higher in patients with restenosis than in those without it. Increased leukocyte CD15 expression during the intervention may contribute to coronary restenosis. Inhibition of leukocyte adhesion may be useful for the prevention of restenosis.
Rauch
Ursula
U
Department of Cardiology and Pulmonology, University Hospital Benjamin Franklin, Free University of Berlin, Berlin, Germany. ursula.rauch@medizin.fu-berlin.de
Wolff
Ursula Maria
UM
Schultheiss
Heinz-Peter
HP
Schwimmbeck
Peter Lothar
PL
D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects; D015415:Biomarkers / Q000097:blood; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000032:analysis; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000601:surgery; D023903:Coronary Restenosis / Q000097:blood* / Q000175:diagnosis / Q000209:etiology; D003331:Coronary Vessels / Q000601:surgery*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007962:Leukocytes / Q000737:chemistry* / Q000166:cytology; D016256:Lewis X Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation
D015415:Biomarkers; D015815:Cell Adhesion Molecules; D016256:Lewis X Antigen