N-nitration of secondary amines with 4-chloro-5-methoxy-2-nitropyridazin-3-one.
N-Nitration of 4-chloro-5-substituted-pyridazin-3-one with copper nitrate trihydrate in acetic anhydride gave the corresponding 4-chloro-2-nitro-5-substituted-pyridazin-3-one. 4-Chloro-5-alkoxy-2-nitropyridazin-3-ones such as 5-methoxy (2b) and 5-ethoxy (2d) derivatives showed excellent nitro group transfer potentiality. N-Nitration of some secondary amines with 2b gave the corresponding N-nitramines under mild neutral condition in good yields.
Park
Young-Dae
YD
Department of Chemistry and Research Institute of Natural Sciences, Gyeongsang National University, Chinju 660-701, Korea.
Kim
Ho-Kyun
HK
Kim
Jeum-Jong
JJ
Cho
Su-Dong
SD
Kim
Sung-Kyu
SK
Shiro
Motoo
M
Yoon
Yong-Jin
YJ