title: [Synthesis of N-[2-(cholesteryloxycarbonylamino) ethyl] carbamoylmethylated mannan].
abstract: OBJECTIVE
  To study the synthesis of chol-AECM-mannan.
  
  
  METHODS
  Using mannan as the main material, we synthesized a compound with polysaccharides partially modified by cholesterol (namely chol-AECM-mannan) through carboxymethylating, carbamoylating and condensation reaction.
  
  
  RESULTS
  The product was confirmed by IR spectrum and 1H nuclear magnetic resonance (1HNMR). The proton integral ratio of mannan and cholesterol is 100: 5, that is to say, the numbers of the substituted cholesterol per 100 mannose units are 1. 1. The production rate is 24%.
  
  
  CONCLUSIONS
  The method is a effective pathway in term of synthesizing chol-AECM-mannan.
authors: Key Laboratory of Biotherapy of Human Diseases, West China Hospital, Sichuan University, Chengdu 610041, China.
authors: Li
authors: L
authors: Yang
authors: Li
authors: L
authors: Cheng
authors: Yuquan
authors: Y
authors: Wei
authors: Ling
authors: L
authors: Tian
mesh_terms: D002784:Cholesterol / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D008081:Liposomes; D009682:Magnetic Resonance Spectroscopy; D008351:Mannans / Q000138:chemical synthesis* / Q000737:chemistry; D013055:Spectrophotometry, Infrared
chemical_list: D008081:Liposomes; D008351:Mannans; C488215:N-(2-(cholesteryloxycarbonylamino)ethyl)carbamoylmethylated mannan; D002784:Cholesterol