title: Oesophageal perforation in preterm neonates: not an innocent bystander.
abstract: OBJECTIVE
  To compare the clinical course and neonatal outcomes of preterm infants with oesophageal perforation (OP).
  
  
  METHODS
  Retrospective case control study of infants admitted between 1994 and 2001 and diagnosed with OP was performed at two tertiary care centres in Toronto, Canada. One control per case was matched by the gestational age and the month of birth. Occurrence of air leak syndrome/pleural effusion requiring drainage, the duration of supplemental oxygen and the time to attain full feeds were compared.
  
  
  RESULTS
  Ten cases of OP were identified. The commonest clinical presentation was air leak syndrome/pleural effusion. There was a statistically significant increase in the time to attain full enteral feeds in OP group (P = 0.02). The duration of supplemental oxygen was prolonged in infants with OP, however, this was statistically insignificant (P = 0.20). The infants were managed conservatively and perforation healed in all.
  
  
  CONCLUSIONS
  Oesophageal perforation is a rare but important complication of modern neonatal intensive care setting. The diagnosis of OP should be considered in infants who present with sudden/acute deterioration in their respiratory status following procedures involving pharyngeal region. Conservative management in an otherwise uncomplicated case leads to complete recovery in neonates.
authors: Departments of Paediatrics, Mount Sinai Hospital, Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada. pshah@mtsinai.on.ca
authors: P S
authors: PS
authors: Shah
authors: M S
authors: MS
authors: Dunn
authors: V S
authors: VS
authors: Shah
mesh_terms: D016022:Case-Control Studies; D004939:Esophageal Perforation / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006776:Hospitals, Pediatric; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D009864:Ontario / Q000453:epidemiology; D011336:Probability; D035583:Rare Diseases; D012016:Reference Values; D012075:Remission, Spontaneous; D012189:Retrospective Studies; D018570:Risk Assessment; D017678:Sex Distribution; D018709:Statistics, Nonparametric