Absence of ATM deletions in 16 cases of splenic marginal-zone B-cell lymphoma (SMZBCL).
We present the study of 16 cases of splenic marginal zone B-cell lymphoma (SMZBL) combining conventional cytogenetics and fluorescence in situ hybridization technique (FISH). We used a locus specific probe (11q22.3) that hybridizes with Ataxia Telangiectasia Mutated gene (ATM) and a centromeric probe of chromosome 11 as a control. Deletions in ATM gene region have been found in B-cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma (MCL) and have been considered as an independent prognosis factor in these pathologies. The aim of our study was to determine the ATM status in SMZBL because no specific studies concerning ATM status in SMZBL have been reported and other B-cell malignances have shown ATM deletions. No deletions were detected in any of the 16 cases. ATM deletions could be considered a rare event in SMZBCL.
Salido
Marta
M
Astier
Laura
L
Puigdecanet
Eulàlia
E
Espinet
Blanca
B
Florensa
Lourdes
L
Solé
Francesc
F
D064007:Ataxia Telangiectasia Mutated Proteins; D018797:Cell Cycle Proteins; D020223:Chromosome Painting; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D004268:DNA-Binding Proteins; D017353:Gene Deletion; D016147:Genes, Tumor Suppressor; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D013160:Splenic Neoplasms / Q000235:genetics*; D025521:Tumor Suppressor Proteins
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D025521:Tumor Suppressor Proteins; C576324:ATM protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D017346:Protein Serine-Threonine Kinases