Role of regulatory T cells in allergy and asthma.
Th2 cells play a critical role in the pathogenesis of allergy and asthma. However, the immunological mechanisms that downmodulate and protect against the development of these disorders are poorly understood. A spectrum of CD4(+) T cells, including Th3 cells, T(R) cells, CD4(+)CD25(+) cells and NKT cells play a critical role in regulating these diseases. A better understanding of the role of regulatory cells in allergic diseases may lead to the identification of novel therapeutic targets.
Akbari
Omid
O
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305-5208, USA.
Stock
Philippe
P
DeKruyff
Rosemarie H
RH
Umetsu
Dale T
DT
D000818:Animals; D001249:Asthma / Q000276:immunology*; D015704:CD4 Antigens / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007108:Immune Tolerance / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D015704:CD4 Antigens; D015375:Receptors, Interleukin-2