Adrenomedullin expression in coronary circulation after stent implantation as a prognostic factor for restenosis.
The authors determined the changes in adrenomedullin (AM) expression in the coronary circulation of patients with ischemic heart disease who underwent coronary stent implantation. Blood samples were drawn from the coronary sinus before, immediately after and four hours after coronary stent implantation, and plasma levels of AM were measured. AM levels in the coronary sinus blood were significantly increased four hours after stent implantation. On the other hand, in the femoral arterial blood, no significant changes in AM levels were observed. A significant positive correlation was found between AM level in the coronary sinus blood four hours after stent implantation and late loss index six months after the procedure. These results suggest that inflammation after coronary stent implantation induces AM expression, which might play an important role in restenosis after stenting.
Hojo
Yukihiro
Y
Division of Cardiovascular Medicine, Jichi Medical School, Tochigi, Japan.
Ikeda
Uichi
U
Mizuno
Osamu
O
Katsuki
Taka-aki
TA
Shimada
Kazuyuki
K
D053607:Adrenomedullin; D015906:Angioplasty, Balloon, Coronary; D016022:Case-Control Studies; D017023:Coronary Angiography; D003326:Coronary Circulation; D023903:Coronary Restenosis / Q000209:etiology; D023921:Coronary Stenosis / Q000097:blood / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000628:therapy*; D010455:Peptides / Q000097:blood*; D011379:Prognosis; D015607:Stents; D013997:Time Factors; D014665:Vasodilator Agents / Q000097:blood*
D010455:Peptides; D014665:Vasodilator Agents; D053607:Adrenomedullin