Expression of activation markers, HLA class II and IL-2R in acute vascular rejection of human renal allografts.
We analyzed the expression of class II antigens on graft tubular cells and the expression of IL-2R on lymphoid cells in 314 prospective aspiration biopsies taken from 30 consecutive patients with histologically verified acute vascular rejection (AVR). Based on histology, two main groups were seen: 11 grafts had features of AVR only and 19 grafts had a combination of AVR and acute cellular rejection (ACR). The AVR findings were also predominant in the latter group. In the grafts with a combination of AVR and ACR, patterns similar to ordinary ACR were seen in class II and IL-2R expression. On the contrary, no class II or IL-2R induction could be seen in the grafts with pure AVR and irreversible rejection. This pattern, demonstrated by immunocytology, suggested that AVR is a heterogenous group of rejections, where different cellular and molecular mechanisms are operating. Humoral mechanisms might be involved in these rejections.
von Willebrand
E
E
Transplantation Laboratory, University of Helsinki, Helsinki, Finland.
Salmela
K
K
Isoniemi
H
H
Taskinen
E
E
Krogerus
L
L
Häyry
P
P
D000208:Acute Disease; D015415:Biomarkers / Q000097:blood; D001707:Biopsy, Needle; D006084:Graft Rejection / Q000145:classification / Q000276:immunology* / Q000473:pathology; D006684:HLA-DR Antigens / Q000097:blood*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology; D011184:Postoperative Period; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012079:Renal Circulation; D013997:Time Factors; D014184:Transplantation, Homologous / Q000276:immunology
D015415:Biomarkers; D006684:HLA-DR Antigens; D015375:Receptors, Interleukin-2