Lacticacidosis after short-term infusion of propofol for anaesthesia in a child with osteogenesis imperfecta.
We describe the case of a 7-year-old boy with osteogenesis imperfecta, who underwent anaesthesia with propofol-fentanyl-nitrous oxide-suxamethonium for orthopaedic surgery of a distal femur fracture. He developed lacticacidosis after short-term propofol infusion (150 min, mean infusion rate 13.5 mg.kg-1.h-1) associated with a prolonged recovery time without serious haemodynamic changes. The highest lactate concentration was 9.2 mmol.l-1 at 160 min after discontinuation of propofol. There was no significant increase in body temperature. The boy fully recovered.
Kill
Clemens
C
Department of Anaesthesiology and Intensive Care Medicine, Philipps-University, Marburg, Germany. killc@mailer.uni-marburg.de
Leonhardt
Andreas
A
Wulf
Hinnerk
H
D000140:Acidosis, Lactic / Q000097:blood / Q000139:chemically induced*; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D002648:Child; D004305:Dose-Response Relationship, Drug; D005215:Fasting / Q000378:metabolism; D005264:Femoral Fractures / Q000150:complications / Q000601:surgery; D005283:Fentanyl / Q000008:administration & dosage; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage; D010013:Osteogenesis Imperfecta / Q000150:complications*; D015742:Propofol / Q000009:adverse effects*; D013390:Succinylcholine / Q000008:administration & dosage; D013997:Time Factors
D018686:Anesthetics, Intravenous; D003473:Neuromuscular Nondepolarizing Agents; D019344:Lactic Acid; D013390:Succinylcholine; D005283:Fentanyl; D015742:Propofol