title: Acute right ventricular failure--from pathophysiology to new treatments.
abstract: The right ventricle (RV) provides sustained low-pressure perfusion of the pulmonary vasculature, but is sensitive to changes in loading conditions and intrinsic contractility. Factors that affect right ventricular preload, afterload or left ventricular function can adversely influence the functioning of the RV, causing ischaemia and right ventricular failure (RVF). As RVF progresses, a pronounced tricuspid regurgitation further decreases cardiac output and worsens organ congestion. This can degenerate into an irreversible vicious cycle. The effective diagnosis of RVF is optimally performed by a combination of techniques including echocardiography and catheterisation, which can also be used to monitor treatment efficacy. Treatment of RVF focuses on alleviating congestion, improving right ventricular contractility and right coronary artery perfusion and reducing right ventricular afterload. As part of the treatment, inhaled nitric oxide or prostacyclin effectively reduces afterload by vasodilating the pulmonary vasculature. Traditional positive inotropic drugs enhance contractility by increasing the intracellular calcium concentration and oxygen consumption of cardiac myocytes, while vasopressors such as norepinephrine increase arterial blood pressure, which improves cardiac perfusion but increases afterload. A new treatment, the calcium sensitiser, levosimendan, increases cardiac contractility without increasing myocardial oxygen demand, while preserving myocardial relaxation. Furthermore, it increases coronary perfusion and decreases afterload. Conversely, traditional treatments of circulatory failure, such as mechanical ventilation and volume loading, could be harmful in the case of RVF. This review outlines the pathophysiology, diagnosis and treatment of RVF, illustrated with clinical case studies.
authors: Department of Anaesthesiology and Critical Care Medicine, Hopital Lariboisière, 2 Rue Ambroise Pare, 75475 , Paris Cedex 10, France. alexandre.mebazaa@lrb.ap-hop-paris.fr.
authors: Alexandre
authors: A
authors: Mebazaa
authors: Department of Anaesthesiology and Critical Care Medicine, Hopital Lariboisière, 2 Rue Ambroise Pare, 75475 , Paris Cedex 10, France.
authors: Peter
authors: P
authors: Karpati
authors: Department of Anaesthesiology and Critical Care Medicine, Hopital Lariboisière, 2 Rue Ambroise Pare, 75475 , Paris Cedex 10, France.
authors: Estelle
authors: E
authors: Renaud
authors: Department of Anaesthesiology-Heart-Lung Division, University Hospital of Lund, 22185, Lund, Sweden.
authors: Lars
authors: L
authors: Algotsson
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002407:Catheterization, Swan-Ganz; D004452:Echocardiography; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012121:Respiration, Artificial; D014662:Vasoconstrictor Agents / Q000627:therapeutic use; D018497:Ventricular Dysfunction, Right / Q000150:complications / Q000503:physiopathology / Q000628:therapy*
chemical_list: D014662:Vasoconstrictor Agents