Remission of severe anemia persisting for over 20 years after eradication of Helicobacter pylori in cases of Ménètrier's disease and atrophic gastritis: Helicobacter pylori as a pathogenic factor in iron-deficiency anemia.
A man with a 20-year history of recurrent iron-deficiency anemia complicated by Helicobacter pylori-positive Ménètrier's disease was observed over a 10-year clinical course, during which time he was successfully treated for the anemia and a gastric Helicobacter pylori (H. pylori) infection through eradication. Considering the satisfactory therapeutic results in this case, we performed eradication therapy on another H. pylori-positive atrophic gastritis case with a 24-year history of iron-deficiency anemia of unknown etiology, and again, complete remission was obtained. The clinical evidence from these two cases suggests that the gastric H. pylori infection was deeply involved in the pathogeneses of the iron-deficiency anemia. We believe that these case reports will provide useful information on H. pylon-involved pathology in the fields of hematology and gastroenterology.
Yoshimura
Makoto
M
Yoshimura Medical Clinic, Fukui.
Hirai
Masamichi
M
Tanaka
Nobuyoshi
N
Kasahara
Yoshio
Y
Hosokawa
Osamu
O
D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000188:drug therapy* / Q000382:microbiology*; D000890:Anti-Infective Agents / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D005296:Ferrous Compounds / Q000627:therapeutic use; D005757:Gastritis, Atrophic / Q000150:complications; D005758:Gastritis, Hypertrophic / Q000150:complications; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D012074:Remission Induction
D000890:Anti-Infective Agents; D000897:Anti-Ulcer Agents; D005296:Ferrous Compounds