Introduction to chromosome dynamics in mitosis.
To ensure that the genetic information, replicated in the S-phase of the cell cycle, is correctly distributed between daughter cells at mitosis, chromatin duplication and chromosome segregation are highly regulated events. Since the early 1980's, our knowledge of the mechanisms governing these two events has greatly increased due to the use of genetic and biochemical approaches. We present here, first, an overview of the replication process, highlighting molecular aspects involved in coupling replication with chromatin dynamics in mitosis. The second part will present the current understanding of chromosome condensation and segregation during mitosis in higher eukaryotes. Finally, we will underline the links that exist between replication and mitosis.
Watrin
Erwan
E
UMR 6061 CNRS, Université de Rennes I, Faculté de Médecine, 2 Avenue du Pr Léon Bernard, 35043 Rennes cedex, France. erwan.watrin@univ-rennes1.fr
Legagneux
Vincent
V
D000251:Adenosine Triphosphatases / Q000502:physiology; D000818:Animals; D002875:Chromosomes / Q000235:genetics* / Q000502:physiology; D004261:DNA Replication; D004250:DNA Topoisomerases, Type II / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D008938:Mitosis; D046912:Multiprotein Complexes; D012854:Sister Chromatid Exchange
D004268:DNA-Binding Proteins; D046912:Multiprotein Complexes; C108312:condensin complexes; D000251:Adenosine Triphosphatases; D004250:DNA Topoisomerases, Type II