Effect of noopept and afobazole on the development of neurosis of learned helplessness in rats.
We studied the effects of new psychotropic preparations noopept and afobazole on acquisition of the conditioned active avoidance response and development of neurosis of learned helplessness in rats. Noopept in doses of 0.05-0.10 mg/kg accelerated acquisition of conditioned active avoidance response and reduced the incidence of learned helplessness in rats. Afobazole in a dose of 5 mg/kg produced an opposite effect, which is probably related to high selective anxiolytic activity of this preparation.
Uyanaev
A A
AA
Department of Pharmacology, Therapeutic Faculty, I. M. Sechenov Moscow Medical Academy. uyanaev@mmascience.ru
Fisenko
V P
VP
Khitrov
N K
NK
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D004151:Dipeptides / Q000494:pharmacology / Q000627:therapeutic use*; D004558:Electric Stimulation; D006380:Helplessness, Learned; D011619:Psychotropic Drugs / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats
D014151:Anti-Anxiety Agents; D004151:Dipeptides; D011619:Psychotropic Drugs; C103871:ethyl phenylacetyl-Pro-Gly