title: Decreased serum opsonic activity against Streptococcus pneumoniae in human immunodeficiency virus-infected Ugandan adults.
abstract: Type-specific immunoglobulin G (IgG) to pneumococcal capsular polysaccharide (CPS) and opsonic activity against Streptococcus pneumoniae were evaluated in serum samples from 36 Ugandan adults with community-acquired pneumonia and 58 asymptomatic Ugandan adults with or without human immunodeficiency virus type 1 (HIV-1) infection. The levels of serum IgG to CPS were significantly higher in HIV-1-infected subjects than in HIV-uninfected subjects. Serum samples from HIV-1-infected subjects that had lower IgG titers demonstrated higher opsonic activity against type 3 (titers of 7) and type 9 (titers of 7-11) pneumococcal strains. Plasma HIV-1 load also correlated inversely with serum opsonic activity against these strains, and peripheral blood CD4+ lymphocyte numbers also tended to correlate with serum opsonic activity in asymptomatic HIV-1-infected adults. Our findings suggest that the opsonic activity of type-specific IgG is impaired in the serum of HIV-1-infected African adults, which may expose them to a serious risk of invasive pneumococcal infections.
authors: Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University, Sakamoto, Nagasaki, Japan.
authors: Hidehiko
authors: H
authors: Takahashi
authors: Kazunori
authors: K
authors: Oishi
authors: Hiroyuki
authors: H
authors: Yoshimine
authors: Atsushi
authors: A
authors: Kumatori
authors: Kazuhiko
authors: K
authors: Moji
authors: Kiwao
authors: K
authors: Watanabe
authors: Hawa
authors: H
authors: Nalwoga
authors: Sitefano Buguruka
authors: SB
authors: Tugume
authors: Anthony
authors: A
authors: Kebba
authors: Roy
authors: R
authors: Mugerwa
authors: Peter
authors: P
authors: Mugyenyi
authors: Tsuyoshi
authors: T
authors: Nagatake
mesh_terms: D000328:Adult; D006678:HIV; D015658:HIV Infections / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D009895:Opsonin Proteins / Q000097:blood / Q000378:metabolism*; D011008:Pneumococcal Infections / Q000150:complications / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology* / Q000502:physiology
chemical_list: D007074:Immunoglobulin G; D009895:Opsonin Proteins