Antiparasitic activity of highly conjugated pyrimidine-2,4-dione derivatives.
4-[2-(1,3-Dimethyl-5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)vinyl]benzaldehyde was synthesized in four steps from 6-methyl-1H,3H-pyrimidine-2,4-dione. This aldehyde was functionalized by various substituted anilines or substituted benzylamines. Antiparasitic activities of the corresponding azomethines were assessed against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum compared to their toxicity versus human cells.
Azas
Nadine
N
Laboratoire de Parasitologie, EA 864, Faculté de Pharmacie, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France. nadine.azas@pharmacie.univ-mrs.fr
Rathelot
Pascal
P
Djekou
Serge
S
Delmas
Florence
F
Gellis
A
A
Di Giorgio
Carole
C
Vanelle
Patrice
P
Timon-David
Pierre
P
D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004912:Erythrocytes / Q000187:drug effects / Q000469:parasitology; D006801:Humans; D018314:Leishmania infantum / Q000187:drug effects / Q000254:growth & development; D009000:Monocytes / Q000187:drug effects; D010963:Plasmodium falciparum / Q000187:drug effects / Q000254:growth & development; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*; D014246:Trichomonas vaginalis / Q000187:drug effects / Q000254:growth & development
D000977:Antiparasitic Agents; D011743:Pyrimidines