title: Antibacterial activity of Leontopodium alpinum (Edelweiss).
abstract: Extracts and individual constituents of Leontopodium alpinum Cass. (Asteraceae) were tested for their antimicrobial activity in two different assays. Extracts were screened in agar diffusion assays, whereas the minimum inhibitory concentrations (MIC) of single compounds were determined by the microbroth dilution method according to NCCLS criteria. Significant antimicrobial activities were found against various strains of Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pneumoniae, and Streptococcus pyogenes strains. These results support the ethnomedicinal use of Leontopodium alpinum for the treatment of respiratory and abdominal disorders.
authors: Institut für Pharmazie, Abteilung Pharmakognosie, Leopold-Franzens-Universität Innsbruck, A-6020 Innsbruck, Austria.
authors: Michael J
authors: MJ
authors: Dobner
authors: Stefan
authors: S
authors: Schwaiger
authors: Ilse H
authors: IH
authors: Jenewein
authors: Hermann
authors: H
authors: Stuppner
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts