[Evaluation of arterial infusion chemotherapy for liver metastasis from gastric cancer].
We evaluated the effectiveness of arterial infusion chemotherapy for liver metastasis from gastric cancer. Nineteen patients (9 synchronous cases, 10 metachronous cases) were treated with hepatic arterial infusion chemotherapy (HAIC). The response rate was 26% (CR 3, PR 2, PD 14), and the median survival time was 357 days after the diagnosis of liver metastasis. The treatment was discontinued in 8 patients because of treatment associated complications and disease progression. Absence of extrahepatic lesion, response of HAIC, and hepatectomy did not improve the prognosis. The combination of systemic chemotherapy with HAIC tended to improve the prognosis. It may be necessary to reevaluate HAIC as a treatment modality for liver metastasis from gastric cancer.
Takeno
Atsushi
A
Dept. of Surgery, Osaka National Hospital.
Fujitani
Kazumasa
K
Tsujinaka
Toshimasa
T
Hirao
Motohiro
M
Takeda
Yutaka
Y
Kashiwazaki
Masaki
M
Mishima
Hideyuki
H
Ikenaga
Masakazu
M
Sawamura
Toshiro
T
Hasuike
Yasunori
Y
D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D009378:Neoplasms, Multiple Primary; D016609:Neoplasms, Second Primary; D013274:Stomach Neoplasms / Q000473:pathology*; D015996:Survival Rate
D016685:Mitomycin; D002945:Cisplatin; D005472:Fluorouracil