Evaluation of standardized versus individualized total parenteral nutrition regime for neonates less than 33 weeks gestation.
OBJECTIVE
To evaluate the difference in nutrient intakes and biochemical responses in newborn infants <33 weeks gestation who received standardized versus individualized total parenteral nutrition (TPN) regimes.


METHODS
Comparison of nutrient intakes and daily biochemical responses in newborn infants <33 weeks gestation who received standardized regime versus those who received individualized TPN regimes from day 2 to day 7 of life.


RESULTS
Twenty-seven infants in the standardized TPN group and 31 infants in the individualized TPN group were compared. There were no statistically significant differences (P > 0.05) between the two groups in gestation, birthweight, Clinical Risk Index for Babies scores, daily TPN volume intake and biochemical responses. Infants in the standardized TPN group received less sodium (P < 0.01) and no potassium on day 2 as required, more protein (P < 0.02) every day, and more calcium and phosphate (P < 0.02 from day 4).


CONCLUSIONS
There were no significant clinical and statistical differences in biochemical responses in newborn infants <33 weeks gestation who received standardized versus individualized TPN regimes during the first week of life. The economic cost of TPN provision using standardized TPN formulation was approximately 30% lower.
Yeung
M Y
MY
Neonatal Intensive Care Unit, Nepean Hospital, New South Wales, Australia. melinda.yeung@swsahs.nsw.gov.au
Smyth
J P
JP
Maheshwari
R
R
Shah
S
S
D003362:Cost-Benefit Analysis; D005526:Food, Formulated / Q000191:economics; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007363:Intensive Care Units, Neonatal; D009517:New South Wales; D015596:Nutrition Assessment; D010289:Parenteral Nutrition, Total / Q000191:economics / Q000379:methods*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric