Hydroxamic acids: proton donor and acceptor strength for use in drug design.
Hydroxamic acids, the naturally occurring and synthetic products, generally have low toxicities and are of interest for many therapeutic applications. The present investigation describes the measurement of hydrogen bond donor (HBD) strength of ten hydroxamic acids by measuring their log P(O/W) values. Hydroxamic acid functional group contains two oxygen and one nitrogen atom as the acceptor sites. Thus, HBA strength of these reagents is also computed. A knowledge of these parameters is valuable in the field of toxicology, pharmacology and environmental sciences.
Vanjari
Harsha
H
School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur, C.G. 492 010, India.
Pande
Rama
R
D015195:Drug Design; D006877:Hydroxamic Acids / Q000737:chemistry*; D011522:Protons
D006877:Hydroxamic Acids; D011522:Protons