[Insulin signal transduction disorder and development of insulin resistance].
Insulin action is initiated through the binding to its cell-surface receptor, stiring up a series of signal transduction and eventually reach various effectors which produce various physiological effects. Insulin signal transduction is crucial to insulin action. Impairment of insulin signal transduction results in attenuation of insulin action and finally leads to insulin resistance. This article reviewed the function of insulin signal transduction disorder in the development of insulin resistance.
Huang
Dong-Mei
DM
Institute of Integrated Traditional and Western Medicine, Affiliated Tongji Hospital, Tongji Medical University, Huazhong Science and Technology University, Wuhan 430030.
Lu
Fu-Er
FE
D000818:Animals; D006801:Humans; D055504:Insulin Receptor Substrate Proteins; D007333:Insulin Resistance / Q000502:physiology*; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D010750:Phosphoproteins / Q000502:physiology; D011972:Receptor, Insulin / Q000502:physiology*; D015398:Signal Transduction
C526292:IRS1 protein, human; D055504:Insulin Receptor Substrate Proteins; D010750:Phosphoproteins; D019869:Phosphatidylinositol 3-Kinases; D011972:Receptor, Insulin