title: Synthesis and antimycobacterial activity of capuramycin analogues. Part 2: acylated derivatives of capuramycin-related compounds.
abstract: Acylated derivatives of capuramycin and A-500359A were synthesized and tested for antimycobacterial activity. Compound 20 having a decanoyl group showed very potent activity.
authors: Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan. hotoda@hq.sankyo.co.jp
authors: Hitoshi
authors: H
authors: Hotoda
authors: Makiko
authors: M
authors: Daigo
authors: Miyuki
authors: M
authors: Furukawa
authors: Kazuhiro
authors: K
authors: Murayama
authors: Chikako Akiyama
authors: CA
authors: Hasegawa
authors: Masakatsu
authors: M
authors: Kaneko
authors: Yasunori
authors: Y
authors: Muramatsu
authors: Michiko Miyazawa
authors: MM
authors: Ishii
authors: Shun-ichi
authors: S
authors: Miyakoshi
authors: Toshio
authors: T
authors: Takatsu
authors: Masatoshi
authors: M
authors: Inukai
authors: Masayo
authors: M
authors: Kakuta
authors: Tomomi
authors: T
authors: Abe
authors: Takashi
authors: T
authors: Fukuoka
authors: Yukio
authors: Y
authors: Utsui
authors: Satoshi
authors: S
authors: Ohya
mesh_terms: D000215:Acylation; D000617:Aminoglycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D007536:Isomerism; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014166:Transferases / Q000037:antagonists & inhibitors
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D011355:Prodrugs; C049983:capuramycin; D014166:Transferases