title: Integron-mediated antibiotic multiresistance in Acinetobacter baumannii clinical isolates from Spain.
abstract: OBJECTIVE
  To determine whether non-epidemiologically related, antibiotic-resistant isolates of Acinetobacter baumannii from different geographical origins possess common type 1 integrons.
  
  
  METHODS
  The epidemiologic relationships between seven A. baumannii strains recovered from different Spanish hospitals were established by pulsed-field gel electrophoresis, the presence of integrons being determined by PCR and DNA sequencing.
  
  
  RESULTS
  Integron analysis showed the presence of four different integrons, containing six different known genes (aacC1, aacA4, aadA1, aadB, oxa21 and oxa37) plus an ORF. It was found that the same integron was present in different unrelated strains and that related strains could have different integrons.
  
  
  CONCLUSIONS
  These results show the potential risk of integron dissemination among different strains of A. baumannii.
authors: Institut Clinic d'Infeccions i Immunologia Clínica, IDIBAPS, Hospital Clínic, Facultat de Medicina, Universitat de Barcelona, Villaroel 170, 08036-Barcelona, Spain.
authors: J
authors: J
authors: Ruiz
authors: M M
authors: MM
authors: Navia
authors: C
authors: C
authors: Casals
authors: J M
authors: JM
authors: Sierra
authors: M T
authors: MT
authors: Jiménez De Anta
authors: J
authors: J
authors: Vila
mesh_terms: D000151:Acinetobacter Infections / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000235:genetics*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D016521:Electrophoresis, Gel, Pulsed-Field; D006801:Humans; D032023:Integrons / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D013030:Spain
chemical_list: D004269:DNA, Bacterial