Parasite antigenaemia and IgG4 antibodies to a filarial protease in an endemic human population in India.
Levels of circulating filarial antigen (Og4C3) and IgG4 antibodies to a filarial protease were determined in subjects of Wuchereria bancrofti exposed sera from Orissa, India. In addition to all individuals with antigenaemia (microfilaraemia), IgG4 antibodies were also detected in some individuals without antigenaemia. A 2-year longitudinal follow-up indicated that IgG4 seropositivity in asymptomatic amicrofilaraemics could be a risk factor for acquiring infection (antigenaemia).
Bal
M S
MS
Division of Immunology, Regional Medical Research Centre, Indian Council of Medical Research, Orissa, India.
Beuria
M K
MK
Mandal
N N
NN
Das
M K
MK
D000293:Adolescent; D000328:Adult; D000818:Animals; D000947:Antigens, Helminth / Q000097:blood*; D002648:Child; D004605:Elephantiasis, Filarial / Q000276:immunology; D019353:Endemic Diseases; D010450:Endopeptidases / Q000276:immunology*; D005368:Filariasis / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007194:India / Q000453:epidemiology; D012307:Risk Factors; D012698:Serologic Tests / Q000379:methods; D014958:Wuchereria bancrofti / Q000201:enzymology / Q000276:immunology*
D000947:Antigens, Helminth; D007074:Immunoglobulin G; D010450:Endopeptidases