title: Indications for and outcome of antidepressant medication in a general population: a prescription database and medical record study, in Jämtland county, Sweden, 1995.
abstract: OBJECTIVE
  To examine the indications for prescribing antidepressants and the clinical outcome when they are prescribed for the treatment of depression, and compare tricyclic antidepressants (TCAs) and selective serotonin re-uptake inhibitors (SSRIs) in these respects.
  
  
  METHODS
  A naturalistic study of a prospective prescription monitoring database and medical records.
  
  
  RESULTS
  Depression was the indication for 23% of the tricyclic treatments and for 82% of the SSRI treatments. A successful treatment of the depression was found in 20% of the TCA cases and 41% of the SSRI cases (NS).
  
  
  CONCLUSIONS
  This study provides evidence that the main use of SSRIs in 1995 is the treatment of depression. The study implies that SSRIs have a more favourable outcome in "real life" than TCAs.
authors: NEUROTEC, Division of Psychiatry, Karolinska Institute, Huddinge University Hospital, S-171 76 Stockholm, Sweden. svante.henriksson@neurotec.ki.se
authors: S
authors: S
authors: Henriksson
authors: G
authors: G
authors: Boëthius
authors: J
authors: J
authors: Håkansson
authors: G
authors: G
authors: Isacsson
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D003628:Database Management Systems; D003866:Depressive Disorder / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D011153:Population; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D013548:Sweden / Q000453:epidemiology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000929:Antidepressive Agents, Tricyclic; D017367:Selective Serotonin Reuptake Inhibitors