title: [End-organ damage in hyperlipidemias].
abstract: Epidemiological and experimental data have clearly demonstrated a strong association between elevated LDL-cholesterol levels and coronary heart disease. In concordance lipid-lowering trials with statins have shown a significant reduction of cardiovascular events. Although stroke is mainly caused by atherosclerotic vascular events, epidemiolgical data have so far failed to show a significant relationship between elevated lipid levels and stroke incidence. However, recent lipid intervention trials with statins have clearly demonstrated a significant reduction in stroke incidence. Moreover, elevated cholesterol levels are thought to contribute to progression of chronic renal insufficiency. In addition, cholesterol crystal emboli are a rare but frequently serious complication of vascular catheter interventions. Significant hypertriglyceridemia carries a significant risk of acute pancreatitis and is thought to contribute to the development of fatty liver disease.
authors: Klinik II und Poliklinik für Innere Medizin, Universität zu Köln.
authors: M
authors: M
authors: Faust
authors: W
authors: W
authors: Krone
mesh_terms: D000328:Adult; D005858:Germany / Q000453:epidemiology; D006331:Heart Diseases / Q000209:etiology; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control*; D007674:Kidney Diseases / Q000209:etiology; D008107:Liver Diseases / Q000209:etiology; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000209:etiology; D010523:Peripheral Nervous System Diseases / Q000209:etiology*; D011984:Sensory Receptor Cells / Q000503:physiopathology