Phenytoin-induced linear IgA dermatosis mimicking toxic epidermal necrolysis.
A 60-year-old woman developed a severe widespread blistering eruption that also involved the palms and soles, but spared the mucosae, approximately 7 days after starting phenytoin. Phenytoin was commenced postoperatively after a craniotomy resection of a glioblastoma multiforme. The clinical features resembled that seen in toxic epidermal necrolysis. However, the patient was systemically well and the histology and immunofluorescence revealed linear IgA dermatosis. The skin lesions began to slowly heal 2 weeks after discontinuation of the phenytoin.
Tran
Diana
D
Royal North Shore Hospital St Leonards, New South Wales, Australia.
Kossard
Steven
S
Shumack
Stephen
S
D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007150:Immunohistochemistry; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use; D018570:Risk Assessment; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology*; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology*
D007070:Immunoglobulin A; D010672:Phenytoin