Analysis of endocrine disruptors, pharmaceuticals, and personal care products in water using liquid chromatography/tandem mass spectrometry.
A method has been developed for the trace analysis of 27 compounds from a diverse group of pharmaceuticals, steroids, pesticides, and personal care products. The method employs solid-phase extraction (SPE) and liquid chromatography/tandem mass spectrometry (LC/MS/MS), using electrospray ionization (ESI) in both positive and negative modes and atmospheric pressure chemical ionization in positive mode. Unlike many previous methods, a single SPE procedure using 1 L of water coupled to a simple LC method is used for all ionization modes. Instrument detection limits for most compounds were below 1.0 pg on column with reporting limits of 1.0 ng/L in water. Recoveries for most compounds in deionized water were greater than 80%. Sulfuric acid was found to be the preferred sample preservative, and structures of all MS/MS product ions are proposed. Matrix effects from waters with a high content of treated municipal effluent were observed in both ESI modes and are discussed in the paper.
Vanderford
Brett J
BJ
Southern Nevada Water Authority, 243 Lakeshore Road, Boulder City, Nevada 89005, USA. brett.vanderford@lvvwd.com
Pearson
Rebecca A
RA
Rexing
David J
DJ
Snyder
Shane A
SA
D002853:Chromatography, Liquid; D005557:Formaldehyde; D006920:Hygiene; D009505:Nevada; D010575:Pesticides / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011310:Preservatives, Pharmaceutical; D012015:Reference Standards; D021241:Spectrometry, Mass, Electrospray Ionization; D013256:Steroids / Q000032:analysis; D013464:Sulfuric Acids; D014867:Water / Q000737:chemistry*; D014873:Water Pollutants / Q000032:analysis*
D010575:Pesticides; D004364:Pharmaceutical Preparations; D011310:Preservatives, Pharmaceutical; D013256:Steroids; D013464:Sulfuric Acids; D014873:Water Pollutants; D014867:Water; D005557:Formaldehyde; C033158:sulfuric acid