title: Effects of pneumoperitoneum on intraoperative pulmonary mechanics and gas exchange during laparoscopic gastric bypass.
abstract: BACKGROUND
  Hypercarbia and elevated intraabdominal pressure resulting from carbon dioxide (CO2) pneumoperitoneum can adversely affect respiratory mechanics. This study examined the changes in mechanical ventilation, CO2 homeostasis, and pulmonary gas exchange in morbidly obese patients undergoing a laparoscopic or open gastric bypass (GBP) procedure.
  
  
  METHODS
  In this study, 58 patients with a body mass index (BMI) of 40 to 60 kg/m2 were randomly allocated to laparoscopic ( n = 31) or open ( n = 27) GBP. Minute ventilation was adjusted to maintain a low normal arterial partial pressure of CO2 (PaCO2), low normal end-tidal partial pressure of CO2 (ETCO2), and low airway pressure. Respiratory compliance, ETCO2, peak inspiratory pressure (PIP), total exhaled CO2 per minute (VCO2), and pulse oximetry (SO2) were measured at 30-min intervals. The acid-base balance was determined by arterial blood gas analysis at 1-h intervals. The pulmonary gas exchange was evaluated by calculation of the alveolar dead space-to-tidal volume ratio (V(Dalv)/V(T)) and alveolar-arterial oxygen gradient (PAO2-PaO2).
  
  
  RESULTS
  The two groups were similar in age, gender, and BMI. As compared with open GBP, laparoscopic GBP resulted in higher ETCO2, PIP, and VCO2, and a lower respiratory compliance. Arterial blood gas analysis demonstrated higher PaCO2 and lower pH during laparoscopic GBP than during open GBP ( p < 0.05). The V(Dalv)/V(T) ratio and PAO2-PaO2 gradient did not change significantly during laparoscopic GBP. Intraoperative oxygen desaturation (SO2 < 90%) did not develop in any of the patients in either group.
  
  
  CONCLUSIONS
  Laparoscopic GBP alters intraoperative pulmonary mechanics and acid-base balance but does not significantly affect pulmonary oxygen exchange. Changes in pulmonary mechanics are well tolerated in morbidly obese patients when proper ventilator adjustments are maintained.
authors: Department of Surgery, University of California, Irvine Medical Center, 101 The City Drive, Building 55, Room 106, Orange, CA 92868, USA. ninhn@uci.edu
authors: N T
authors: NT
authors: Nguyen
authors: J T
authors: JT
authors: Anderson
authors: M
authors: M
authors: Budd
authors: N W
authors: NW
authors: Fleming
authors: H S
authors: HS
authors: Ho
authors: J
authors: J
authors: Jahr
authors: C M
authors: CM
authors: Stevens
authors: B M
authors: BM
authors: Wolfe
mesh_terms: D000136:Acid-Base Equilibrium; D000328:Adult; D000713:Anastomosis, Roux-en-Y; D015992:Body Mass Index; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D015390:Gastric Bypass; D006801:Humans; D006935:Hypercapnia / Q000209:etiology*; D010535:Laparoscopy; D008170:Lung Compliance; D008297:Male; D008875:Middle Aged; D010092:Oximetry; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects; D011659:Pulmonary Gas Exchange; D015656:Respiratory Mechanics; D013990:Tidal Volume
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen