title: Gastroprotective effect of leptin on gastric mucosal injury induced by ischemia-reperfusion is related to gastric histamine content in rats.
abstract: Leptin has cytoprotective effect to gastric mucosal injury in rats. We aimed to test the hypothesis that leptin induced histamine is involved in the prevention of ischemia-reperfusion (I/R) induced gastric mucosal injury in rats. At the end of the 30 min celiac artery occlusion and 12h reperfusion process, serum and gastric tissue samples were taken from three group of rats to measure oxidative status, histamine levels and for histological examinations. Leptin decreased ulcer and polymorphonuclear leukocyte (PMNL) index, and serum malondialdehyde (MDA) and protein carbonyl content but increased gastric tissue histamine levels. We concluded that leptin exerts a protective effect on gastric mucosa to I/R induced gastric injury probably through increasing tissue histamine content which, in turn, maintain the gastric mucosal blood flow.
authors: Department of Physiology, Medical Faculty, Osmangazi University, Eskişehir, Turkey. nerkasap@ogu.edu.tr
authors: Nilüfer
authors: N
authors: Erkasap
authors: Kubilay
authors: K
authors: Uzuner
authors: Mustafa
authors: M
authors: Serteser
authors: Tülay
authors: T
authors: Köken
authors: Yasemin
authors: Y
authors: Aydin
mesh_terms: D000818:Animals; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D006632:Histamine / Q000378:metabolism*; D020738:Leptin / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000188:drug therapy*
chemical_list: D020738:Leptin; D006632:Histamine