Peptide derivatives of antibiotics tylosin and desmycosin, protein synthesis inhibitors.
Biologically active peptide derivatives of 16-member macrolide antibiotics were synthesized as potential probes for the investigation of nascent peptide chain topography in the ribosomal exit tunnel. The tylosin and desmycosin aldehyde groups at the C6 position of the lactone ring were modified by the aminooxyacetyl-L-alanyl-L-alanine methyl ester.
Sumbatyan
N V
NV
Faculty of Chemistry, Lomonosov Moscow State University, Moscow, 119992, Russia.
Korshunova
G A
GA
Bogdanov
A A
AA
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D014176:Protein Biosynthesis; D011500:Protein Synthesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry*; D015645:Tylosin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
D000900:Anti-Bacterial Agents; D010455:Peptides; D011500:Protein Synthesis Inhibitors; D015645:Tylosin