Effect of morphine and M-cholinoceptor blocking drugs on human sphincter of Oddi during choledochofiberscopy manometry.
OBJECTIVE
To evaluate the effects of morphine on the human sphincter of Oddi pressure and the antagonism of anticholinergic agents against morphine.


METHODS
The action of these drugs on the sphincter of Oddi (SO) was evaluated by means of choledochofiberscopy manometry in 40 operated patients with T-tube. The patients were divided randomly into 4 groups: anisodamine, atropine, buscopan, and control. The following data were recorded: duodenal pressure (DP), basal pressure of the sphincter of Oddi (BPSO), contractive amplitude of the sphincter of Oddi (CASO), contractive frequency of the sphincter of Oddi (CFSO), contractive duration of the sphincter of Oddi (CDSO), and pressure of the common bile duct (PCBD). Both morphine and anticholinergic agents were given intramuscularly.


RESULTS
After injection of 10 mg morphine, BPSO, CASO, CFSO, and PCBD increased significantly. After injection of 15 mg anisodamine or 0.75 mg atropine, CASO, BPSO declined obviously, and after injection of 20 mg buscopan, CASO, BPSO, CFSO declined obviously, but in anisodamine, atropine and buscopan groups, they differed insignificantly.


CONCLUSIONS
The results illustrate that SO manometry via choledochofiberscopy is a new method for SO dynamic study. Morphine can increase DP, BPSO, CASO, PCBD, but anisodamine atropine and buscopan can antagonize the effect of morphine.
Wu
Shuo-Dong
SD
Department of Hepatobiliary, Second Affiliated Hospital, China Medical University, Shenyang 110004, China.
Kong
Jing
J
Wang
Wei
W
Zhang
Qiang
Q
Jin
Jun-Zhe
JZ
D000328:Adult; D000368:Aged; D001285:Atropine / Q000494:pharmacology; D002086:Butylscopolammonium Bromide / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000494:pharmacology*; D004336:Drug Antagonism; D016145:Endoscopy, Digestive System / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods; D008875:Middle Aged; D009020:Morphine / Q000494:pharmacology*; D009294:Narcotics / Q000494:pharmacology*; D011312:Pressure; D011950:Receptors, Cholinergic / Q000187:drug effects*; D012991:Solanaceous Alkaloids / Q000494:pharmacology; D009803:Sphincter of Oddi / Q000187:drug effects* / Q000502:physiology
D018680:Cholinergic Antagonists; D009294:Narcotics; D011950:Receptors, Cholinergic; D012991:Solanaceous Alkaloids; C003922:anisodamine; D002086:Butylscopolammonium Bromide; D009020:Morphine; D001285:Atropine