Synthesis and cytotoxicity of 5-fluorouracil/diazeniumdiolate conjugates.
5-Fluorouracil/diazeniumdiolate conjugates were first synthesized, and showed greater cytotoxicities than 5-fluorouracil for DU 145 human prostate and HeLa cancer cells.
Cai
Tingwei Bill
TB
Departments of Biochemistry and Chemistry, The Ohio State University, OH 43210, USA. pgwang@chemistry.ohio-state.edu
Tang
Xiaoping
X
Nagorski
Janet
J
Brauschweiger
Paul G
PG
Wang
Peng George
PG
D001391:Azo Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D005472:Fluorouracil / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008297:Male
D001391:Azo Compounds; C452539:diazeniumdiolate; D005472:Fluorouracil