[Prognostic value of high-sensitivity C-reactive protein in assessing intrahospital outcome of unstable angina].
Inflammation has been shown to play an important role in the pathogenesis of unstable angina. CRP has been demonstrated to be a reliable marker of prognosis is unstable angina. The aim of this study was to investigate the prognostic value of CRP in assessing short outcome of unstable angina. Our study is a prospective double blinded one. We measured CRP in 33 consecutive patients admitted for unstable angina at the 24th and 48th hour. The mean age is 60 years (30 to 84 years). There were 22 men and 11 women. 8 patients were included in class I of Braunwald classification, 5 were in class II and 20 in class III. 14 patients presented cardiac events. The CRP mean value was significantly higher among these patients (12 mg/l vs 5 mg/l, p < 10.4). Patients having a CRP > or = 3 mg/l have a higher risk of developing complications (66% vs 13%, p = 0.002). Elevation of CRP predicted poor outcome of intrahospital evolution with a sensitivity of 86%, a specificity 68%, a positive and negative predictive values of 66% and 86%. The CRP in our preliminary study is an independent risk factor of early outcome of unstable angina. In association with clinical scores and other cardiac markers will lead to a better identification of high risk patients.
Ben Halima
Afef
A
Service de Cardiologie, Hôpital Abderrahmen Mami, L'Ariana.
Kammoun
Ikram
I
Sdiri
Wissem
W
Bachraoui
Kaouther
K
Chine
Samira
S
Zoaoui
Walid
W
Châabène
Olfa
O
Gargouri
Sami
S
Keskes
Hend
H
Lefi
Abdellatif
A
Ben Ammar
Slim
S
Boujnah
M Rachid
MR
Kachboura
Salem
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000097:blood* / Q000145:classification; D002097:C-Reactive Protein / Q000032:analysis*; D004311:Double-Blind Method; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D014416:Tunisia
D002097:C-Reactive Protein