IL-6, TNF-alpha and atherosclerosis risk indicators in a healthy family population: the STANISLAS cohort.
There are no satisfactory data on circulating concentrations of inflammatory cytokines and their potential relationship with traditional and nontraditional atherosclerosis risk factors in a large healthy young population. The present study was conducted to examine, in 179 healthy families selected from the STANISLAS cohort, the association between interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP), orosomucoid, haptoglobin, cell-adhesion molecules (ICAM-1, E-, L- and P-selectin) and lipid parameter concentrations. Age, BMI, white blood cells and tobacco consumption contributed to the variation of IL-6 concentrations. Age and tobacco contributed also to TNF-alpha variation. Taking into account potential covariates, we showed strong positive correlation between IL-6 and both inflammatory markers TNF-alpha and CRP in parents and in offspring (P<0.001). In parents, IL-6 was associated with ICAM-1 and L-selectin (P<0.01), while IL-6 and TNF-alpha predicted E-selectin in offspring only (0.001<P<0.01). Furthermore, IL-6 showed a strong negative relationship with apo A-1 and HDL-cholesterol in females only (P<0.001). This study demonstrated that in a large healthy family population, children included, levels of IL-6 are closely associated with traditional and non-traditional atherosclerosis risk factors. All these data are useful for defining the precise role of cytokines in atherosclerosis mechanisms in physiological conditions.
Haddy
Nadia
N
INSERM Unite 525 equipe 4, Centre de Médecine Préventive, 2, avenue du Doyen Jacques Parisot, 54501 Vandoeuvre-lès-Nancy, France.
Sass
Catherine
C
Droesch
Suzanne
S
Zaiou
Mohamed
M
Siest
Gérard
G
Ponthieux
Anne
A
Lambert
Daniel
D
Visvikis
Sophie
S
D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood; D001161:Arteriosclerosis / Q000097:blood* / Q000235:genetics; D002097:C-Reactive Protein / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D005192:Family Health; D005260:Female; D005602:France; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D012307:Risk Factors; D019087:Selectins / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D016632:Apolipoprotein A-I; D008076:Cholesterol, HDL; D018836:Inflammation Mediators; D015850:Interleukin-6; D008055:Lipids; D019087:Selectins; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein