Does polymorphism C1377T of the calcitonin receptor gene determine bone mineral density in postmenopausal women?
In a cross-sectional study we investigated the potential association between CALCR polymorphism (C1377T) and bone mineral density in 114 postmenopausal women. T homozygotes had higher BMD (g/cm2) at the femoral neck compared with carriers of C allele (p < 0.02, ANCOVA). Means of BMD at the lumbar spine did not differ among the genotypes (ANCOVA). In conclusion, the CALCR gene is associated with bone mass at the femoral neck in postmenopausal women.
Zofková
I
I
Institute of Endocrinology, Prague, Czech Republic. izofko@endo.cz
Zajícková
K
K
Hill
M
M
Krepelová
A
A
D000483:Alleles; D015519:Bone Density / Q000235:genetics*; D003430:Cross-Sectional Studies; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005260:Female; D005272:Femur Neck / Q000502:physiology; D006801:Humans; D008159:Lumbar Vertebrae / Q000502:physiology; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause / Q000235:genetics*; D018003:Receptors, Calcitonin / Q000235:genetics*
D018003:Receptors, Calcitonin; D004247:DNA