title: A randomized controlled trial using the school for anti-inflammatory therapy in asthma.
abstract: This study investigated the impact of providing low-dose inhaled corticosteroids (ICS) at school or at home to asthmatic inner city children over a 14-week period, compared with the existing community standard. Eight elementary schools in the Dallas Independent School District with a high incidence of asthma located in predominantly urban African-American communities were randomly assigned to one of four groups. The treatment arms were school-based delivery of inhaled steroids, home-based delivery of inhaled steroids, and home-based delivery of inhaled steroids with school-based asthma education, and the control group was no change in current therapy. Fifty students were objectively diagnosed with mild, persistent asthma and participated in the study. Students in the treatment arms received beclomethasone (42 mcg/puff) 4 puffs, twice a day, either at school or at home. Students in the control, "community standard of care" group received no additional medical intervention. Higher peak flows for the treatment groups were seen in the first week and maintained throughout the study (P = .047). By week 5 significant differences were found in frequency of bronchodilator use (P = .025), episodes of nocturnal awakening with asthma symptoms (P = .022), and visits to the primary health care provider (P = .022). Treatment groups rated their asthma as "better than the week before" more frequently than the control group (P = .001). Delivering ICS in school is associated with improved asthma control than when anti-inflammatory medication was delivered to children with asthma in a home-based setting, and both are superior when compared with a control, "community standard of care" group in which no additional medical intervention occurred.
authors: Asthma and Pulmonary Rehabilitation Center, Baylor University Medical Center, Dallas, Texas, USA.
authors: Mark Warren
authors: MW
authors: Millard
authors: Pauline T
authors: PT
authors: Johnson
authors: Melanie
authors: M
authors: McEwen
authors: Jacquelin
authors: J
authors: Neatherlin
authors: Gretchen
authors: G
authors: Lawrence
authors: Donald K
authors: DK
authors: Kennerly
authors: Joanna L
authors: JL
authors: Bokovoy
mesh_terms: D000280:Administration, Inhalation; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy*; D001507:Beclomethasone / Q000008:administration & dosage*; D002648:Child; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D010353:Patient Education as Topic; D012572:School Health Services; D014504:Urban Health
chemical_list: D018927:Anti-Asthmatic Agents; D005938:Glucocorticoids; D001507:Beclomethasone