Differentially functionalized diamines as novel ligands for the NPY2 receptor.
The synthesis of novel ligands for the NPY(2) receptor using solid phase split pool methodology is described. One of the analogues, diamine 16, was found to be a potent NPY(2) binder.
Andres
Charles J
CJ
Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492, USA.
Antal Zimanyi
Ildiko
I
Deshpande
Milind S
MS
Iben
Lawrence G
LG
Grant-Young
Katharine
K
Mattson
Gail K
GK
Zhai
Weixu
W
D000215:Acylation; D045744:Cell Line, Tumor; D003959:Diamines / Q000138:chemical synthesis / Q000378:metabolism*; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands; D009447:Neuroblastoma / Q000378:metabolism; D011869:Radioligand Assay; D017476:Receptors, Neuropeptide Y / Q000378:metabolism*; D013329:Structure-Activity Relationship
D003959:Diamines; D008024:Ligands; D017476:Receptors, Neuropeptide Y; C095889:neuropeptide Y2 receptor