title: A study of the effect on nucleophilic hydrolytic activity of pancreatic elastase, trypsin, chymotrypsin, and leucine aminopeptidase by boronic acids in the presence of arabinogalactan: a subsequent study on the hydrolytic activity of chymotrypsin by boronic acids in the presence of mono-, di-, and trisaccharides.
abstract: The hydrolytic activity of trypsin, chymotrypsin, elastase, and leucine aminopeptidase, is inhibited by different boronic acids. However, all the enzymes are inhibited by the compound CbzAla(boro)Gly(OH)(2). Therefore, these additives can control the nucleophilic hydrolytic activity of these enzymes.
authors: Department of Medicinal Chemistry and Natural Products, Faculty of Medicine, The Hebrew University in Jerusalem, P.O. Box 12065, 91120 Jerusalem, Israel.
authors: Reem
authors: R
authors: Smoum
authors: Abraham
authors: A
authors: Rubinstein
authors: Morris
authors: M
authors: Srebnik
mesh_terms: D001897:Boronic Acids / Q000494:pharmacology*; D002918:Chymotrypsin / Q000737:chemistry* / Q000378:metabolism; D004187:Disaccharides / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005685:Galactans; D006868:Hydrolysis / Q000187:drug effects; D007931:Leucyl Aminopeptidase / Q000737:chemistry* / Q000378:metabolism; D009005:Monosaccharides / Q000494:pharmacology; D010196:Pancreatic Elastase / Q000737:chemistry* / Q000378:metabolism; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology; D014312:Trisaccharides / Q000494:pharmacology; D014357:Trypsin / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001897:Boronic Acids; D004187:Disaccharides; D004791:Enzyme Inhibitors; D005685:Galactans; D009005:Monosaccharides; D015842:Serine Proteinase Inhibitors; D014312:Trisaccharides; D007931:Leucyl Aminopeptidase; D002918:Chymotrypsin; D010196:Pancreatic Elastase; D014357:Trypsin; C005653:arabinogalactan