title: Herpes simplex virus in the respiratory tract of critical care patients: a prospective study.
abstract: BACKGROUND
  Herpes simplex virus (HSV) is occasionally detected in the lower respiratory tract of patients in intensive care, but its clinical importance in such situations remains unclear. We did a prospective cohort study to define the prevalence, origin, risk factors, and clinical relevance of HSV in the respiratory tract of patients undergoing critical care.
  
  
  METHODS
  We tested 764 patients admitted to intensive care for the presence of HSV in the respiratory tract, and assessed statistical relations between this virus and clinical variables.
  
  
  RESULTS
  HSV was detected by oropharyngeal swab in the upper respiratory tract of 169 (22%) of 764 patients, within 10 days of admission for 150 (89%) of these individuals. The virus was isolated in 58 (16%) of 361 patients whose lower respiratory tract was sampled. The presence of HSV in the throat was a risk factor for development of HSV infections in the lower respiratory tract (p<0.001). HSV was isolated most frequently in patients with severe disease. HSV in the throat was associated with acute respiratory distress syndrome (p<0.001) and with increased length of stay in intensive care (p<0.001).
  
  
  CONCLUSIONS
  Our data suggest that HSV reactivation or infection of the upper respiratory tract is frequent among patients in intensive care, and is a risk factor for development of lower respiratory tract infection with this virus, possibly by means of aspiration.
authors: Department of Microbiology, University Hospital of Antwerp, Antwerp, Belgium. peggy.bruynseels@uza.be
authors: Peggy
authors: P
authors: Bruynseels
authors: Philippe G
authors: PG
authors: Jorens
authors: Hendrik E
authors: HE
authors: Demey
authors: Herman
authors: H
authors: Goossens
authors: Stefaan R
authors: SR
authors: Pattyn
authors: Monique M
authors: MM
authors: Elseviers
authors: Joost
authors: J
authors: Weyler
authors: Leo L
authors: LL
authors: Bossaert
authors: Yves
authors: Y
authors: Mentens
authors: Margareta
authors: M
authors: Ieven
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001240:Aspirations, Psychological; D001530:Belgium / Q000453:epidemiology; D018893:Bronchoalveolar Lavage; D003422:Critical Care / Q000706:statistics & numerical data; D016638:Critical Illness / Q000628:therapy; D005260:Female; D006561:Herpes Simplex / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D009960:Oropharynx / Q000821:virology; D015995:Prevalence; D011446:Prospective Studies; D012128:Respiratory Distress Syndrome / Q000453:epidemiology / Q000821:virology; D012137:Respiratory System / Q000821:virology*; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000821:virology; D012307:Risk Factors; D018139:Simplexvirus / Q000302:isolation & purification*; D014780:Viruses / Q000302:isolation & purification