[Memantine for the treatment of dementia].
Problems in the Netherlands with respect to the reimbursement of memantine have led the patient organization 'Alzheimer Nederland' to establish an emergency fund. Several trials have documented the limited, but consistent beneficial effects of memantine in severely demented patients. It is not clear which subgroup of patients might benefit the most. The drug seems to have dopamimetic and antidepressant effects which might explain its overall effect. The publicity surrounding memantine contributes to an atmosphere in which patients and care providers have to explain why they are not yet using 'anti-dementia drugs'. This should be avoided. Patients can expect to gain more benefit from ongoing, thorough and independent investigations than from hastily established emergency funds to finance the use of a drug with a limited and poorly defined efficacy.
van Gool
W A
WA
Academisch Medisch Centrum, afd. Neurologie, Postbus 22.700, 1100 DE Amsterdam. w.a.vangool@amc.uva.nl
Eikelenboom
P
P
D003704:Dementia / Q000188:drug therapy*; D015259:Dopamine Agents / Q000191:economics / Q000627:therapeutic use*; D006801:Humans; D007349:Insurance, Health, Reimbursement; D008559:Memantine / Q000191:economics / Q000627:therapeutic use*; D009426:Netherlands; D016896:Treatment Outcome
D015259:Dopamine Agents; D008559:Memantine