Interleukin-6 levels in hyperemesis gravidarum.
BACKGROUND
Hyperemesis gravidarum (HG) is associated with higher levels of serum beta-hCG levels and hyperthyroidism. Interleukin-6 (IL-6), a pro-inflammatory cytokine, is reported to enhance secretion of beta-hCG from trophoblastic cell line.


METHODS
We measured serum levels of IL-6, thyroid hormones and beta-hCG of hyperemetic patients and gestational age-matched controls to search for a difference between the two groups.


RESULTS
There was a significant difference in beta-hCG ( p=0.028), though IL-6 levels were higher in the hyperemetic group, it did not reach a significant level. Interleukin-6 positively correlated with beta-hCG ( r=0.38 and p=0.13).
Kuscu
Naci K
NK
Department of Obstetrics and Gynecology, School of Medicine, Celal Bayar University, 45020 Manisa, Turkey. kemal.kuscu@bayar.edu.tr
Yildirim
Yasemin
Y
Koyuncu
Faik
F
Var
Ahmet
A
Uyanik
Bekir S
BS
D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood*; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D018709:Statistics, Nonparametric; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D006063:Chorionic Gonadotropin; D015850:Interleukin-6; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine