title: Chlamydia pneumoniae DNA in peripheral blood mononuclear cells in healthy control subjects and patients with diabetes mellitus, acute coronary syndrome, stroke, and arterial hypertension.
abstract: Infection with Chlamydia pneumoniae has been suggested to play a role in the development and maintenance of atherosclerosis based on differences in the prevalence of antibodies against Chlamydia pneumoniae in patients with and without atherosclerotic lesions. We evaluated the prevalence of Chlamydia pneumoniae DNA in the white cells of the peripheral blood in 194 patients with diabetes mellitus, 50 patients with acute coronary syndrome, 102 hypertensive patients, 193 patients having suffered a stroke and in 368 healthy subjects with a nested polymerase chain reaction (nPCR). Overall the prevalence of Chlamydia pneumoniae DNA in peripheral blood cells was: diabetes mellitus (11.9%), stroke (10.4%), hypertension (6.9%), acute coronary syndrome (4.0%) and healthy subjects (7.9%). The prevalence of Chlamydia pneumoniae DNA in the patients was not significantly different from prevalence in the healthy subjects. However, a significant association was found between high levels of triglycerides and presence of C. pneumoniae DNA (OR = 3.27, p < 0.04). The prevalence of C. pneumoniae DNA was not associated with age, gender, smoking, BMI, HDL, CRP, plasma creatinine and symptoms or signs of ischaemic heart disease. The association between high levels of triglycerides and C. pneumoniae DNA suggests that infection by C. pneumoniae affects lipid metabolism.
authors: Department of Medicine, Holstebro Hospital, Holstebro, Denmark. ajam@ringamt.dk
authors: Jakob
authors: J
authors: Müller
authors: Dorthe S
authors: DS
authors: Møller
authors: Mogens
authors: M
authors: Kjaer
authors: Ole
authors: O
authors: Nyvad
authors: Niels A
authors: NA
authors: Larsen
authors: Erling B
authors: EB
authors: Pedersen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000382:microbiology*; D016022:Case-Control Studies; D023521:Chlamydophila Infections / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D016993:Chlamydophila pneumoniae / Q000235:genetics / Q000302:isolation & purification*; D003327:Coronary Disease / Q000097:blood / Q000382:microbiology; D004269:DNA, Bacterial / Q000032:analysis*; D003920:Diabetes Mellitus / Q000097:blood / Q000382:microbiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000382:microbiology; D007963:Leukocytes, Mononuclear / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000382:microbiology; D014280:Triglycerides / Q000097:blood
chemical_list: D004269:DNA, Bacterial; D014280:Triglycerides