title: Stability of intravesical epirubicin infusion: a sequential temperature study.
abstract: OBJECTIVE
  To investigate the stability of epirubicin bladder instillation, prepared from two different epirubicin formulations, under refrigerated storage, transportation and clinical use conditions.
  
  
  METHODS
  A sequential study design was used. Epirubicin instillation (1 mg/mL) in polypropylene syringes was sequential incubated for periods of 84 days at 8 degrees C followed by 2 h at 25 degrees C and 1 h at 37 degrees C, the latter two temperatures replicating transport and intravesical conditions, respectively.
  
  
  RESULTS
  The instillation was both chemically and physically stable under those incubation conditions. The formulation of epirubicin used to prepare the instillation infusions did not affect stability.
authors: Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, UK. prsgjs@bath.ac.uk
authors: G J
authors: GJ
authors: Sewell
authors: A E
authors: AE
authors: Rigby-Jones
authors: M J
authors: MJ
authors: Priston
mesh_terms: D000283:Administration, Intravesical; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical; D002853:Chromatography, Liquid; D004355:Drug Stability; D004356:Drug Storage; D015251:Epirubicin / Q000008:administration & dosage*
chemical_list: D000903:Antibiotics, Antineoplastic; D015251:Epirubicin