title: Glucose-regulated stress proteins and antibacterial immunity.
abstract: The role of stress proteins in immunity and their feasibility as vaccine vehicles against infectious disease have been the focus of intensive examination. Endoplasmic reticulum (ER)-resident stress proteins in particular are interesting model proteins as they perform crucial functions in an organelle that responds promptly to cell stress. We describe transcriptional regulation of ER-resident stress proteins, their involvement in the cellular response to infection and discuss their potential as vaccine candidates against infectious diseases.
authors: Max Planck Institute for Infection Biology, Schumannstrasse 21-22, 10117 Berlin, Germany. rapp@mpiib-berlin.mpg.de
authors: Ulrike K
authors: UK
authors: Rapp
authors: Stefan H E
authors: SH
authors: Kaufmann
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D015551:Autoimmunity; D001692:Biological Transport; D004721:Endoplasmic Reticulum / Q000276:immunology* / Q000378:metabolism; D005786:Gene Expression Regulation; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology*; D011401:Promoter Regions, Genetic
chemical_list: D018840:HSP70 Heat-Shock Proteins; D008565:Membrane Proteins; C018551:glucose-regulated proteins