Glycine transporters not only take out the garbage, they recycle.
Two articles in the current issue of Neuron examine the consequences of deleting the two genes that encode glycine transporters. Interestingly, loss of glial transporters enhances while loss of presynaptic neuronal transporters reduces glycinergic transmission. These two opposing phenotypes resemble distinct human diseases characterized by dysfunction in glycinergic signaling.
Brasnjo
Gabor
G
Department of Neurobiology, School of Medicine, University of California, Los Angeles, CA 90095, USA.
Otis
Thomas S
TS
D026921:Amino Acid Transport Systems, Neutral / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D005998:Glycine / Q000378:metabolism*; D050487:Glycine Plasma Membrane Transport Proteins; D006801:Humans; D051379:Mice; D008818:Mice, Neurologic Mutants; D009433:Neural Inhibition / Q000235:genetics; D009457:Neuroglia / Q000378:metabolism; D017729:Presynaptic Terminals / Q000378:metabolism*; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D009435:Synaptic Transmission / Q000235:genetics*
D026921:Amino Acid Transport Systems, Neutral; D050487:Glycine Plasma Membrane Transport Proteins; D020033:Protein Isoforms; D005998:Glycine