title: Polarizing the Nazarov cyclization: efficient catalysis under mild conditions.
abstract: Substituted divinyl ketones were studied in the Nazarov cyclization. alpha-Carbomethoxy divinyl ketones underwent efficient Nazarov cyclization with catalytic copper triflate (2 mol %) to give a single cyclopentenone regio- and stereoisomer. The efficiency of the cyclizations correlated with the ability of the substituents to favorably polarize the pi-system of the cationic intermediate.
authors: Department of Chemistry, University of Rochester, Rochester, NY 14627, USA.
authors: Wei
authors: W
authors: He
authors: Xiufeng
authors: X
authors: Sun
authors: Alison J
authors: AJ
authors: Frontier