title: A prospective controlled study of a computer-assisted acenocoumarol dosage program.
abstract: The increase in oral anticoagulant (OA) treatment has led to development of new strategies for its control. We tested the efficacy of the GAO software (Dade Behring) in providing adequate acenocoumarol dosages for patients whose international normalised ratios (INRs) were no more than 0.5 points out of range. From December 1998 to August 1999, all outpatients in this setting were randomly assigned to receive computer-generated or traditionally fixed OA doses. Patients in their first 4 weeks of treatment were excluded. Overall, 8352 dosages were calculated by the computer and 7586 by the medical staff. The main endpoint of the study was the time spent in target INR range. The computer matched the traditional dosing, achieving a small but statistically significant greater efficacy in maintaining patients within the INR target range. The percentage of INR determinations over 5.5 was very low in both groups. Our results validate the computerised acenocoumarol dosing in our centre, achieving at least similar levels of effectiveness and safety compared with traditional dosage by medical staff.
authors: Servicio de Hematología del Hospital Universitario 'Marqués de Valdecilla', Universidad de Cantabria, Santander, Spain. fmarco@telefonica.net
authors: Fernando
authors: F
authors: Marco
authors: Carmen
authors: C
authors: Sedano
authors: Arancha
authors: A
authors: Bermúdez
authors: Mónica
authors: M
authors: López-Duarte
authors: Elena
authors: E
authors: Fernández-Fontecha
authors: Alberto
authors: A
authors: Zubizarreta
mesh_terms: D000074:Acenocoumarol / Q000008:administration & dosage*; D000284:Administration, Oral; D000367:Age Factors; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage; D001835:Body Weight; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D005260:Female; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D000074:Acenocoumarol