Ca2+/calcineurin signalling in cells of the immune system.
Calcineurin is a serine-threonine - phosphatase that is expressed in a wide variety of tissues and has particularly critical functions in neurons, cardiac and skeletal muscle cells, and lymphocytes. This review focuses on recent studies elucidating the role of Ca(2+)/calcineurin signalling of the immune system.
Feske
Stefan
S
Department of Pathology, Harvard Medical School, Boston and The CBR Institute for Biomedical Research, 200 Longwood Ave., Boston, MA 02115, USA.
Okamura
Heidi
H
Hogan
Patrick G
PG
Rao
Anjana
A
D019703:Calcineurin / Q000276:immunology* / Q000378:metabolism*; D002118:Calcium / Q000276:immunology* / Q000378:metabolism*; D020013:Calcium Signaling / Q000276:immunology / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000276:immunology / Q000378:metabolism; D007111:Immunity, Cellular / Q000276:immunology / Q000502:physiology; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D014157:Transcription Factors / Q000276:immunology / Q000378:metabolism; D015533:Transcriptional Activation / Q000276:immunology
D004268:DNA-Binding Proteins; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D014157:Transcription Factors; D019703:Calcineurin; D002118:Calcium