Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation.
Gene expression profiling of beta-catenin, Cripto and Wnt3 mutant mouse embryos has been used to characterise the genetic networks that regulate early embryonic development. We have defined genes whose expression is regulated by beta-catenin during formation of the anteroposterior axis and the mesoderm, and have identified Cripto, which encodes a Nodal co-receptor, as a primary target of beta-catenin signals both in embryogenesis as well as in colon carcinoma cell lines and tissues. We have also defined groups of genes regulated by Wnt3/beta-catenin signalling during primitive streak and mesoderm formation. Our data assign a key role to beta-catenin upstream of two distinct gene expression programs during anteroposterior axis and mesoderm formation.
Morkel
Markus
M
Max Delbrueck Center for Molecular Medicine, Robert-Roessle-Strasse 10, 13125 Berlin, Germany.
Huelsken
Joerg
J
Wakamiya
Maki
M
Ding
Jixiang
J
van de Wetering
Marc
M
Clevers
Hans
H
Taketo
Makoto M
MM
Behringer
Richard R
RR
Shen
Michael M
MM
Birchmeier
Walter
W
D000818:Animals; D019521:Body Patterning / Q000235:genetics*; D015820:Cadherins / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000235:genetics*; D004815:Epidermal Growth Factor; D005786:Gene Expression Regulation / Q000235:genetics*; D006133:Growth Substances / Q000235:genetics; D008562:Membrane Glycoproteins; D008648:Mesoderm / Q000502:physiology*; D051379:Mice; D016296:Mutagenesis; D009154:Mutation; D009363:Neoplasm Proteins / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D015534:Trans-Activators / Q000502:physiology*; D051153:Wnt Proteins; D060508:Wnt3 Protein; D051176:beta Catenin
C495267:CTNNB1 protein, mouse; D015820:Cadherins; D003598:Cytoskeletal Proteins; D006133:Growth Substances; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D011506:Proteins; C489450:Tdgf1 protein, mouse; D015534:Trans-Activators; D051153:Wnt Proteins; D060508:Wnt3 Protein; C555508:Wnt3 protein, mouse; D051176:beta Catenin; D004815:Epidermal Growth Factor