Detection of peptidoglycans by NOD proteins.
Mechanisms of innate immune defense are based on the recognition of invariant microbial molecular patterns by specific receptors, followed by the activation of signaling pathways and the expression of effector molecules that will defeat the invading microorganism. Two recent reports add to the growing list of these pattern-recognition receptors by showing that the intracellular nucleotide-binding oligomerization domain 1 (NOD1) protein recognizes a diaminopimelate-containing muropeptide, a cell-wall component of Gram-negative bacteria.
Royet
Julien
J
UPR 9022 CNRS, IBMC, 15 Rue René Descartes, Université Louis Pasteur, 67084 cedex, Strasbourg, France. J.Royet@ibmc.u-strasbg.fr
Reichhart
Jean Marc
JM
D048868:Adaptor Proteins, Signal Transducing; D017209:Apoptosis; D002352:Carrier Proteins / Q000502:physiology*; D006094:Gram-Positive Bacteria / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D053474:Nod1 Signaling Adaptor Protein; D009842:Oligopeptides / Q000032:analysis* / Q000737:chemistry; D010457:Peptidoglycan / Q000737:chemistry* / Q000494:pharmacology; D011971:Receptors, Immunologic / Q000378:metabolism; D015398:Signal Transduction
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; C119067:NOD1 protein, human; D053474:Nod1 Signaling Adaptor Protein; D009842:Oligopeptides; D010457:Peptidoglycan; D011971:Receptors, Immunologic