Genistein appears to prevent early postmenopausal bone loss as effectively as hormone replacement therapy.
Recent data from a randomized, double-blind, placebo-controlled, yearlong clinical trial suggest that supplementation with the dietary phytoestrogen genistein (54 mg/day) may be as effective as hormone replacement therapy in attenuating menopause-related bone loss without causing the associated side effects. These findings may have implications for the development of diet-based strategies aimed at osteoporosis prevention.
Cotter
Alice
A
Department of Food and Nutritional Sciences, University College, Cork, Ireland.
Cashman
Kevin D
KD
D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D015519:Bone Density / Q000187:drug effects; D005260:Female; D019833:Genistein / Q000627:therapeutic use*; D020249:Hormone Replacement Therapy; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control*; D013997:Time Factors
D016588:Anticarcinogenic Agents; D019833:Genistein