title: Cholinesterase inhibitory activity of two farnesylacetone derivatives from the brown alga Sargassum sagamianum.
abstract: Two known farnesylacetone derivatives (1 and 2) were isolated from the Korean brown alga Sargassum sagamianum off Jeju Island, Korea. Compounds 1 and 2 were identified as (5E,10Z)-6,10,14-trimethylpentadeca-5,10-dien-2,12-dione and (5E,9E,13E)-6,10,4-trimethyl-pentadeca-5,9,13-trien-2,12-dione, respectively, by comparison with the literature data. Compounds 1 and 2 showed moderate acetylcholinesterase and butyrylcholinesterase inhibitory activities with IC50 values of 65.0 approximately 48.0 and 34.0 approximately 23.0 microM, respectively.
authors: Regional Research Center, Department of Chemical Technology, Hanbat National University, 16-1 Dukmyung-dong, Yusung-gu, Daejon 305-719, Korea.
authors: Geonseek
authors: G
authors: Ryu
authors: Soo Hee
authors: SH
authors: Park
authors: Eun Sook
authors: ES
authors: Kim
authors: Byoung Wook
authors: BW
authors: Choi
authors: Shi Yong
authors: SY
authors: Ryu
authors: Bong Ho
authors: BH
authors: Lee
mesh_terms: D002091:Butyrylcholinesterase / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D007536:Isomerism; D007659:Ketones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000459:Phaeophyceae / Q000737:chemistry*; D044647:Sargassum / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C487422:6,10,14-trimethylpentadeca-5,10-dien-2,12-dione; C487423:6,10,14-trimethylpentadeca-5,9,13-trien-2,12-dione; D002800:Cholinesterase Inhibitors; D007659:Ketones; D013729:Terpenes; C014549:farnesylacetone; D002091:Butyrylcholinesterase