title: [Retrospective study of malignant melanoma patients treated with mistletoe extracts].
abstract: OBJECTIVE
  The aim of the present investigation was to analyze survival time and survival rate of all patients with malignant melanoma who had been counseled at the Tumorambulanz Herdecke of the Community Hospital Herdecke.
  
  
  METHODS
  284 melanoma patients were included in a retrospective questionnaire study. Only those patients were considered for analysis in whom the prognostic factors histology, tumor localization, and Clark level were known. The data of the study population were compared with patient data obtained from the literature.
  
  
  RESULTS
  94 patients were included in the analysis. 66 of whom had received and 7 had not received mistletoe treatment, in the remaining 21 patients there was no information whether or not mistletoe treatment had been given. Thus, we did our study without a clearly defined internal control group. The median survival time among patients treated with mistletoe had been 14.1 years. The 5- and 10-year survival rates were 80 and 68% for the mistletoe-treated patients, respectively.
  
  
  CONCLUSIONS
  The 5-year survival rate of the mistletoe-treated patients is comparable to that of patients without mistletoe therapy while the 10-year survival rate is a little bit lower. This may be due to the fact that, in contrast to the patients from the relevant literature, 33.3% of the patients suffered from lymph node and/or distant metastases already before counseling the Tumorambulanz Herdecke. Moreover, 50% of our patients had melanoma of Clark level IV in contrast to 22.2% or 31% in the relevant literature.
  
  
  CONCLUSIONS
  In spite of the theoretical reservations against mistletoe treatment in melanoma patients, our retrospective analysis did not show any clues about disadvantages of mistletoe treatment in melanoma patients. A controlled prospective study therefore should prove the efficacy of a mistletoe therapy in patients with malignant melanoma.
authors: Krebsforschung Herdecke e.V., Gemeinschaftskrankenhaus Herdecke, Universität Witten/Herdecke, Deutschland.
authors: C
authors: C
authors: Stumpf
authors: A
authors: A
authors: Rosenberger
authors: S
authors: S
authors: Rieger
authors: W
authors: W
authors: Tröger
authors: M
authors: M
authors: Schietzel
authors: G M
authors: GM
authors: Stein
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000188:drug therapy*; D008875:Middle Aged; D014784:Mistletoe; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D010936:Plant Extracts