title: Human blood groups: inheritance and importance in transfusion medicine.
abstract: Human blood group antigens are unique, inherited polymorphisms on the extracellular surface of red blood cells. They have been used as genetically discrete markers of human polymorphism since the discovery of the ABO system in 1900. Since then, many blood group antigens have been identified, the genes cloned, and their biological significance elucidated. Blood group antigens and antibodies play an important role in Transfusion Medicine. In addition, blood groups have provided anthropologists with a tool to study polymorphism in the different peoples across the world and provided geneticists with inherited markers to understand complex mechanisms of linkage and disease inheritance.
authors: Blood Centre, University Hospital, 22185 Lund, Sweden.
authors: Jill R
authors: JR
authors: Storry
mesh_terms: D001741:Black or African American / Q000235:genetics; D001789:Blood Group Antigens / Q000145:classification / Q000235:genetics*; D001803:Blood Transfusion / Q000379:methods* / Q000639:trends; D005787:Gene Frequency; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic / Q000235:genetics; D015995:Prevalence; D065227:Transfusion Reaction; D014481:United States; D044465:White People / Q000235:genetics
chemical_list: D001789:Blood Group Antigens; D005819:Genetic Markers