Comparison between sublobar resection and 125Iodine brachytherapy after sublobar resection in high-risk patients with Stage I non-small-cell lung cancer.
BACKGROUND
Sublobar resection (SR) can be performed in high-risk non-small-cell lung carcinoma (NSCLC) patients but is associated with an increased local recurrence. This abstract reviews our intraoperative (125)Iodine brachytherapy experience after SR in high-risk Stage I NSCLC patients and compares these results with our previous series of SR alone in similar patients.


METHODS
One hundred two Stage I NSCLC patients who underwent SR alone were compared with 101 Stage I patients who underwent SR and intraoperative (125)Iodine brachytherapy placed over the SR staple line.


CONCLUSIONS
Local recurrence after SR and (125)Iodine brachytherapy (2%) in high-risk Stage I NSCLC patients was significantly less than after SR alone (18.6%). This safe, pulmonary function-preserving and practical intraoperative brachytherapy method should be considered when SR is used as a "compromise" therapy in these patients.
Santos
Ricardo
R
Division of General Thoracic Surgery, Department of Radiation Oncology, Allegheny General Hospital, 320 E. North Avenue, Pittsburgh, PA 15212, USA.
Colonias
Athanasios
A
Parda
David
D
Trombetta
Mark
M
Maley
Richard H
RH
Macherey
Robin
R
Bartley
Susan
S
Santucci
Tibetha
T
Keenan
Robert J
RJ
Landreneau
Rodney J
RJ
D001918:Brachytherapy; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008168:Lung / Q000601:surgery*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy*; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011182:Postoperative Care; D013902:Radiography, Thoracic; D018570:Risk Assessment; D014057:Tomography, X-Ray Computed
D007457:Iodine Radioisotopes