title: The sensitivity of axillary staging when using sentinel node biopsy in breast cancer.
abstract: OBJECTIVE
  We aimed to study factors, which enhance the sensitivity of sentinel node biopsy.
  
  
  METHODS
  Three hundred and sixty-three clinically node negative breast cancer patients with successful sentinel node biopsy were studied. All focally radioactive and/or blue nodes in the axilla were harvested. All palpably suspicious lymph nodes were also removed for a similar histological evaluation.
  
  
  RESULTS
  Sentinel node metastases were found in 129 patients. The metastasis was detected in the three first retrieved sentinel nodes in 126 cases and in the fourth or fifth node in three cases. The 'hottest' sentinel node was not the involved one in 18 cases. Five patients with tumour negative sentinel nodes had metastases in other palpably suspicious nodes.
  
  
  CONCLUSIONS
  Harvesting all focally radioactive and/or blue nodes and other palpably suspicious nodes minimises the false negative rate in sentinel node biopsy. Removal of more than five nodes does not significantly improve the sensitivity of axillary staging.
authors: Breast Surgery Unit, Maria Hospital, Helsinki, Finland. marjut.leidenius@hus.fi
authors: M
authors: M
authors: Leidenius
authors: L
authors: L
authors: Krogerus
authors: T
authors: T
authors: Toivonen
authors: E
authors: E
authors: Leppänen
authors: K
authors: K
authors: von Smitten
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology*; D004396:Coloring Agents; D005260:Female; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy; D013668:Technetium Tc 99m Aggregated Albumin
chemical_list: D004396:Coloring Agents; D013668:Technetium Tc 99m Aggregated Albumin; C083602:technetium Tc 99m nanocolloid