title: Successful use of 111In-pentetrotide scintigraphy for localizing ectopic adrenocorticotropin-producing bronchial carcinoid tumor in a patient with Cushing's syndrome.
abstract: A 34-year-old man was diagnosed with clinical Cushing's syndrome based on circadian fluctuation of plasma adrenocorticotropin and serum cortisol levels and Liddle's-method. The presence of ectopic adrenocorticotropin production was suspected. Urine 5-hydroxyindoleaceturic acid level was high. Chest computed-tomography scan revealed a mass in the right upper lung. 111In-pentetrotide scintigraphy demonstrated marked accumulation in the right upper lung. We suspected an adrenocorticotropin-producing bronchial carcinoid. Plasma adrenocorticotropin and serum cortisol levels decreased immediately following resection of the tumor. Adrenocorticotropin production by tumor cells was confirmed by immunohistochemistry. This case indicates 111In-pentetrotide scintigraphy could be successfully used to identify and localize ectopic adrenocorticotropin-producing bronchial carcinoid.
authors: Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka.
authors: Ken
authors: K
authors: Kishida
authors: Makoto
authors: M
authors: Moriwaki
authors: Jun-ichiro
authors: J
authors: Miyagawa
authors: Kohei
authors: K
authors: Okita
authors: Takashi
authors: T
authors: Kondo
authors: Kimiko
authors: K
authors: Itoh
authors: Satoshi
authors: S
authors: Umemura
authors: Junji
authors: J
authors: Kozawa
authors: Hiromi
authors: H
authors: Iwahashi
authors: Tohru
authors: T
authors: Yoshizumi
authors: Akihisa
authors: A
authors: Imagawa
authors: Kazuya
authors: K
authors: Yamagata
authors: Takao
authors: T
authors: Maruyama
authors: Hiroyuki
authors: H
authors: Toyoshima
authors: Eiji
authors: E
authors: Kurokawa
authors: Tohru
authors: T
authors: Funahashi
authors: Yuji
authors: Y
authors: Matsuzawa
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000000981:diagnostic imaging / Q000209:etiology*; D000328:Adult; D001984:Bronchial Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D002276:Carcinoid Tumor / Q000150:complications / Q000000981:diagnostic imaging / Q000378:metabolism*; D003480:Cushing Syndrome / Q000209:etiology*; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D011877:Radionuclide Imaging; D013004:Somatostatin / Q000031:analogs & derivatives*
chemical_list: D007205:Indium Radioisotopes; D013004:Somatostatin; C081788:pentetreotide