[Relationship between macrophage migration inhibitory factor and cardiac function in patients with congestive heart failure].
OBJECTIVE
To examine the level of plasma macrophage migration inhibitory factor (MIF) in patients with congestive heart failure (CHF) and its relationship with cardiac function.


METHODS
The levels of MIF were measured in 278 CHF patients and 85 normal subjects using enzyme-linked immuno-sorbent assay (ELISA).


RESULTS
Elevated MIF levels were detected in the patients with heart failure, and the elevation was more significant in cases of coronary artery disease in comparison with that identified in cases of dilated cardiomyopathy.


CONCLUSIONS
The overactivation of MIF may be involved in the pathogenesis of heart failure.
Liu
Yuan
Y
Department of Cardiology, Guangdong Provincial Cardiovascular Institute, Guangzhou 510080, China.
Yu
Xi-yong
XY
Lin
Qiu-xiong
QX
Yang
Min
M
Shan
Zhi-xin
ZX
Zheng
Meng
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002311:Cardiomyopathy, Dilated / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood*; D008297:Male; D008875:Middle Aged
D008263:Macrophage Migration-Inhibitory Factors