title: Pustular generalized perforating granuloma annulare.
abstract: We report a 84-year-old man with a 13-year history of recurrent generalized asymptomatic pustular lesions. Histology revealed areas of necrobiosis surrounded by palisading granulomas and transepidermal and follicular elimination of the necrobiotic material. A dense infiltrate of neutrophils was also found. Although 26% of patients with generalized perforating granuloma annulare have some yellow pustule-like papules, these correspond histologically to the yellow viscous necrobiotic material extruding through the epidermis and not to a real neutrophilic infiltrate. This is the first case report of perforating granuloma annulare with recurrent generalized pustular lesions with a dense infiltrate of neutrophils.
authors: Department of Dermatology, Hospital 12 de Octubre, Avda de Andalucía Km 5.400, 28041 Madrid, Spain. reyesgamo@vodafone.es
authors: R
authors: R
authors: Gamo Villegas
authors: J
authors: J
authors: Sopena Barona
authors: A
authors: A
authors: Guerra Tapia
authors: A
authors: A
authors: Vergara Sanchez
authors: J L
authors: JL
authors: Rodríguez Peralto
authors: L
authors: L
authors: Iglesias DIez
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016460:Granuloma Annulare / Q000473:pathology*; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000473:pathology; D012008:Recurrence