Littoral cell angioma of the spleen in a patient with severe aplastic anaemia.
Littoral cell angioma (LCA) is a rare benign tumour of the spleen. We describe a patient with aplastic anaemia who, following multiple treatments with rabbit and horse Anti-Thymocyte Globulin and anabolic steroids developed marked splenomegaly and hypersplenism. LCA was diagnosed post splenectomy. This is the first case of LCA associated with aplastic anaemia and its treatment.
Tholouli
Eleni
E
Department of Haematology and Histopathology, Manchester Royal Infirmary, Manchester, UK.
Roulson
Jo-An
JA
Byers
Richard
R
Burton
Ian
I
Liu Yin
John A
JA
D000741:Anemia, Aplastic / Q000150:complications* / Q000188:drug therapy; D000818:Animals; D000961:Antilymphocyte Serum / Q000009:adverse effects; D001803:Blood Transfusion; D016572:Cyclosporine / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006391:Hemangioma / Q000139:chemically induced / Q000150:complications*; D006736:Horses; D006801:Humans; D006971:Hypersplenism / Q000209:etiology; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D008875:Middle Aged; D010110:Oxymetholone / Q000009:adverse effects / Q000627:therapeutic use; D011817:Rabbits; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000139:chemically induced / Q000150:complications*; D013601:T-Lymphocytes
D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D010110:Oxymetholone