Gastric bypass in a Japanese man with Prader-Willi syndrome and morbid obesity.
BACKGROUND
In Prader-Willi syndrome (PrWS), marked obesity is the most serious and common complication, contributing significantly to morbidity and mortality. Because of the associated psychosocial difficulties, bariatric surgery appears to be the only effective treatment.


METHODS
A 30-year-old man with PrWS weighing 108 kg (BMI 50 kg/m2), underwent Roux-en-Y gastric bypass (RYGBP). 3 months before the RYGBP, he weighed 146 kg (BMI 68.5), partly because of heart failure. 18 months after RYGBP, he weighed 92.4 kg (BMI 43.3), with no postoperative complications. Moreover, he showed considerable increase in serum HDL-cholesterol levels with reciprocal reduction in LDL-cholesterol after the surgery.


CONCLUSIONS
RYGBP resulted in satisfactory weight loss and improvement in serum lipid profile in a Japanese morbidly obese patient with PrWS.
Kobayashi
Junji
J
Department of Internal Medicine, Shimotsuga General Hospital, Tochigi City, Tochigi, Japan. maryland95@angel.ne.jp
Kodama
Masaaki
M
Yamazaki
Kazuma
K
Morikawa
Okamichi
O
Murano
Shunichi
S
Kawamata
Norifumi
N
Kawamura
Isao
I
D000328:Adult; D000713:Anastomosis, Roux-en-Y; D002784:Cholesterol / Q000097:blood; D015390:Gastric Bypass / Q000379:methods*; D006801:Humans; D007564:Japan; D008297:Male; D009767:Obesity, Morbid / Q000209:etiology / Q000601:surgery*; D011218:Prader-Willi Syndrome / Q000150:complications*; D013270:Stomach / Q000601:surgery*; D015431:Weight Loss
D002784:Cholesterol