Cell cycle regulation by the B-Myb transcription factor.
The expression of genes required for progression through the cell cycle is highly modulated through a regulatory axis containing the E2F transcription factor and retinoblastoma tumour suppressor protein families. One of the genes regulated through this mechanism encodes the B-Myb transcription factor, which has been shown to be critically required for early embryonal development in the mouse. Transcriptional activity of B-Myb is substantially enhanced in S phase through modification by cyclin A/cdk2, and the evidence points squarely to the major role being played by B-Myb during this phase of the cell cycle. We discuss in this review recent findings suggesting that B-Myb is a multifunctional protein that has, in addition to its transcriptional properties, the ability to interact directly with other regulators of the cell cycle.
Joaquin
M
M
Ludwig Institute for Cancer Research and Department of Virology, Faculty of Medicine, St Mary's Campus, Imperial College London, Norfolk Place, London W2 1PG, United Kingdom. mjoaquin@fmi.ch
Watson
R J
RJ
D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins; D019938:Cyclin D1 / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D050684:E2F Transcription Factors; D006801:Humans; D009687:Nuclear Proteins / Q000502:physiology; D010766:Phosphorylation; D011401:Promoter Regions, Genetic; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic; D025801:Ubiquitin / Q000378:metabolism
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; C064352:MYBL2 protein, human; D009687:Nuclear Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D025801:Ubiquitin; D019938:Cyclin D1