[Bacteriostasis of iodoform in vivo and in vitro].
OBJECTIVE
To investigate the bacteriostasis of iodoform in vivo and in vitro.


METHODS
Bacteriostasis of iodoform and economycin against different species of bacteria was observed in vitro and the curves of bacteriostasis were obtained for each agent. In rabbit models traumatic liver injury complicated by infection of the wounds with Staphylococcus aureus, Escherichia coli and Pseudomonas aerudomonas, common bandage supplemented respectively with 6% iodoform, 10% iodoform, economycin ointment, and saline were applied for wound addressing and the changes in the number of bacterium in the wounds was measured 1, 3, and 7 days later, respectively.


RESULTS
Iodoform showed better bacteriostatic effect than economycin in inhibiting the growth of the majority of the aerobic bacteria in vitro, and its action on anaerobic bacteria appeared similar to the effect of economycin. In rabbit models, iodoform at the concentration of 10% showed significantly better bacteriostatic effect against the 3 species of bacteria than economycin (P<0.01).


CONCLUSIONS
Iodoform possesses more potent bacteriostatic effect than economycin against most bacteria.
Tang
Li-jun
LJ
Department of Organ Transplatation, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. lijun_tang36@163.com
Gao
Yi
Y
Zhao
Zi-lin
ZL
Long
Jun
J
Zhou
Dong-yao
DY
D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D015169:Colony Count, Microbial; D003470:Culture Media; D005260:Female; D006847:Hydrocarbons, Iodinated / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008297:Male; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D014946:Wound Infection / Q000188:drug therapy / Q000382:microbiology
D003470:Culture Media; D006847:Hydrocarbons, Iodinated; C010473:iodoform