title: Stress-induced fever after postischemic rectal temperature measurements in the gerbil.
abstract: Postischemic temperature, which modulates brain injury, is commonly determined via a rectal temperature (Trec) probe. This procedure causes a stress-induced fever (SIF) in rodents that may aggravate injury or diminish the efficacy of a neuroprotectant. We continually measured core temperature (Tcore) via an implanted telemetry probe and made 16 Trec measurements over 4 days in sham and ischemic gerbils (5 min bilateral carotid artery occlusion). Controls did not have Trec sampled, but Tcore was measured. Rectal temperature measurements predicted Tcore in sham and ischemic gerbils. The Trec measurements caused a SIF (1 degrees C peak) in shams that did not habituate, whereas the SIF was initially absent and then increased over days in ischemic gerbils. Ischemic groups had similar CA1 injury (approximately 32% remaining), presumably because Trec measurements only resulted in a significant SIF starting on day 2 postischemia, when cell death is less sensitive to hyperthermia. Caution is warranted with Trec measurements, since the resultant SIF occurs to different extents in normal and ischemic rodents. Furthermore, the SIF could vary according to many other factors, such as the type and severity of insult, the time and frequency of measurement, and drug treatment. Accordingly, postischemic Trec measurements should be replaced with telemetry probes.
authors: Department of Psychology, Center for Neuroscience, P217 Biological Sciences Building, University of Alberta, Edmonton, Alberta T6G 2E9, Canada.
authors: Darren L
authors: DL
authors: Clark
authors: Suzanne B
authors: SB
authors: DeBow
authors: Melanie D
authors: MD
authors: Iseke
authors: Frederick
authors: F
authors: Colbourne
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000502:physiology*; D001921:Brain / Q000503:physiopathology; D004195:Disease Models, Animal; D004567:Electrodes, Implanted; D005260:Female; D005334:Fever / Q000209:etiology* / Q000503:physiopathology; D005849:Gerbillinae; D017202:Myocardial Ischemia / Q000503:physiopathology; D012007:Rectum / Q000503:physiopathology*; D013312:Stress, Physiological / Q000150:complications* / Q000503:physiopathology; D013997:Time Factors