[Association of angiotensinogen gene polymorphism with hypertension in type 2 diabetic patients].
OBJECTIVE
To investigate the relationship between angiotensinogen (AGT) gene polymorphism and hypertension in type 2 diabetic patients.


METHODS
A total of 240 patients with type 2 diabetes mellitus were divided into normotensive and hypertensive groups according to their blood pressure measurement, and their fasting plasma glucose, total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein and very-low-density lipoprotein were measured. The AGT genotypes were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).


RESULTS
The distributions of AGT genotypes in normotensive and hypertensive groups were similar, and the frequency of M allele in female hypertensive patients was significantly higher than that in female normotensive patients.


CONCLUSIONS
The M allele of AGT gene is probably related to hypertension in female type 2 diabetic patients.
Xue
Yao-ming
YM
Department of Endocrinology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Guan
Mei-ping
MP
Liu
Shi-qun
SQ
Zhang
Qian
Q
Zhou
Lin
L
D000328:Adult; D000368:Aged; D000808:Angiotensinogen / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D000808:Angiotensinogen