Viridepyronone, a new antifungal 6-substituted 2H-pyran-2-one produced by Trichoderma viride.
A new antifungal 6-substituted 2H-pyran-2-one, named viridepyronone, has been isolated from a cultural filtrate of a strain of Trichoderma viride showing antagonistic activity in vitro toward Sclerotium rolfsii, which is the causal agent of crown and stem rot of artichoke. Viridepyronone was characterized as 6-(4-oxopentyl)-2H-pyran-2-one 2 with spectroscopic methods. Bioassays showed that viridepyronone had a good antifungal activity against S. rolfsii, and its minimum inhibitory concentration (over 90% inhibition) was found to be 196 microg/mL. This is the first report of viridepyronone produced by any species of fungi.
Evidente
Antonio
A
Dipartimento di Scienze del Suolo, della Pianta e dell'Ambiente, Università di Napoli Federico II, 80055 Portici, Italy. evidente@unina.it
Cabras
Annalisa
A
Maddau
Lucia
L
Serra
Salvatorica
S
Andolfi
Anna
A
Motta
Andrea
A
D005659:Fungicides, Industrial / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D010935:Plant Diseases / Q000382:microbiology; D020072:Polyporales / Q000187:drug effects; D014242:Trichoderma / Q000378:metabolism*
D005659:Fungicides, Industrial