Regulation of neuronal morphogenesis and synaptic function by Abl family kinases.
Recent studies provide insights into the mechanisms by which Abelson non-receptor tyrosine kinases relay information from axon guidance and growth factor receptors to promote cytoskeletal rearrangements in developing neurons. Abelson non-receptor tyrosine kinases are also found in mature synapses, where their activities are required for optimal synaptic function.
Moresco
Eva M Y
EM
Department of Genetics, Yale School of Medicine, PO Box 208024, New Haven, CT 06520-8204, USA. eva.moresco@yale.edu
Koleske
Anthony J
AJ
D000818:Animals; D016313:Genes, abl / Q000502:physiology*; D006801:Humans; D009024:Morphogenesis / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
D011505:Protein-Tyrosine Kinases