title: Head and neck cancer patients with pulmonary nodules: value and role of CT-guided transthoracic needle aspiration biopsies.
abstract: BACKGROUND
  To evaluate transthoracic needle aspiration biopsies of pulmonary lesions in patients with squamous cell cancer of head and neck.
  
  
  METHODS
  Retrospective series of 85 patients with squamous cell cancer of head and neck cancer and pulmonary nodules who underwent CT-guided needle aspiration biopsy.
  
  
  RESULTS
  Diagnostic samples were obtained in 85% of patients. There were 8 benign and 77 malignant lesions. Among the 73 proved cases, 4 were false-negative cases. CT-guided biopsy had an accuracy of 81%, a sensitivity of 94%, and a negative predictive value of 60%. Accuracies were 68% for lesions of 20 mm or smaller and 89% for lesions greater than 20 mm. In a subset of 45 solitary lesions, among 30 positive biopsies, 15 were categorized as primary malignancies, 3 as metastatic, and 12 as indeterminate malignancies.
  
  
  CONCLUSIONS
  In head and neck cancer patients, the prevalence of thoracic malignancies is high when a pulmonary lesion is detected. CT-guided biopsy of pulmonary lesion is an accurate procedure. However, a third of positive biopsies were categorized as indeterminate malignancies.
authors: Department of Radiology, Institut Gustave-Roussy, 39 rue Camille Desmoulins, F-94805 Villejuif Cedex, France. benoit.mesurolle@muhc.mcgill.ca
authors: Benoît
authors: B
authors: Mesurolle
authors: François
authors: F
authors: Mignon
authors: Philippe
authors: P
authors: Meingan
authors: Christian
authors: C
authors: Domenge
authors: Manuella
authors: M
authors: Vasile
authors: Robert
authors: R
authors: Sigal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000556:secondary*; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000473:pathology*; D012680:Sensitivity and Specificity; D003074:Solitary Pulmonary Nodule / Q000473:pathology*; D025321:Surgery, Computer-Assisted; D014057:Tomography, X-Ray Computed