Interdigitation--fusion liposomes.
IF-liposomes are formed by a unique process that involves fusing small liposomes into interdigitated lipid sheets, using either ethanol or hydrostatic pressure. The interdigitation-fusion method requires liposome formulations with lipids that form the L beta I phase. Preparing ethanol-induced IF-liposomes is simple and quick. IF-liposomes are particularly well suited for biomembrane research experiments that require large unilamellar liposomes and for liposome drug delivery applications that require a high drug-to-lipid ratio.
Ahl
Patrick L
PL
Bio Delivery Sciences International, Inc., UMDNJ-New Jersey Medical School, 185 South Orange Avenue, ADMC4 Newark, New Jersey 07103, USA.
Perkins
Walter R
WR
D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry*; D005456:Fluorescent Dyes; D005614:Freeze Fracturing; D007202:Indicators and Reagents; D008051:Lipid Bilayers / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D008561:Membrane Fusion; D008854:Microscopy, Electron; D010316:Particle Size; D014961:X-Ray Diffraction / Q000379:methods
D005456:Fluorescent Dyes; D007202:Indicators and Reagents; D008051:Lipid Bilayers; D008081:Liposomes; D015060:1,2-Dipalmitoylphosphatidylcholine