title: [A report of two cases--two patients of the extremely advanced hepatocellular carcinoma have responded completely for a long time after a combination therapy consisting of arterial chemotherapy and injection of interferon-alpha].
abstract: The prognosis of advanced hepatocellular carcinoma (HCC) is extremely poor. Patient 1 was a 43-year-old male with major portal tumor thrombi. He received combination therapy consisting of continuous arterial infusion (MTX 30 mg/m2, day 1, CDDP/5-FU 6 mg/m2: 250 mg/m2, day 1-14) and subcutaneous injection of IFN-alpha (500 x 10(4) U, 3 times a week, 4 weeks). Patient 2 was a 66-year-old male with major hepatic venous tumor thrombi. He received combination therapy consisting of continuous arterial infusion (5-FU 6 mg/m2: 250 mg/m2, day 1-14) and subcutaneous injection of IFN-alpha (500 x 10(4) U, 3 times a week, 4 weeks). Decrease in tumor was observed in both patients markers and marked regression of tumor was observed in both patients. They are still in complete response. This combination therapy is an effective strategy for advanced HCC.
authors: Dept. of Surgery, Gastrointestinal Research Center, Minoh City Hospital.
authors: Shohei
authors: S
authors: Iijima
authors: Nobuaki
authors: N
authors: Kikkawa
authors: Eiji
authors: E
authors: Kurokawa
authors: Hitoshi
authors: H
authors: Yamamoto
authors: Takeshi
authors: T
authors: Kato
authors: Masaki
authors: M
authors: Tsujie
authors: Satoshi
authors: S
authors: Ohshima
authors: Taro
authors: T
authors: Hayashi
authors: Yasuto
authors: Y
authors: Naoi
authors: Toshihiro
authors: T
authors: Hatanaka
authors: Michiki
authors: M
authors: Danno
authors: Masato
authors: M
authors: Sakon
authors: Hiroaki
authors: H
authors: Nagano
authors: Keizo
authors: K
authors: Dono
authors: Shoji
authors: S
authors: Nakamori
authors: Koji
authors: K
authors: Umeshita
authors: Morito
authors: M
authors: Monden
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D007261:Infusions, Intra-Arterial; D007279:Injections, Subcutaneous; D016898:Interferon-alpha / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D011379:Prognosis; D012074:Remission Induction
chemical_list: D016898:Interferon-alpha; D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate