Hypothyroidism does not affect the dihydropyridine sensitivity of precontracted murine uterus.
Thyroid hormones are known to influence various processes of cell differentiation. Recently, it was reported that hypothyroidism reduces the sensitivity to Ca2+-channel antagonists in the rat uterus. We examined the sensitivity to dihydropyridines of the uterus from mice that had reduced thyroid hormone levels. Isradipine relaxed with the same potency precontracted uterine muscle strips from control and hypothyroid mice, independently from a pseudo-pregnant state. These results demonstrate that hypothyroidism does not change dihydropyridine sensitivity (i.e., the pattern of Ca2+-channel expression) in the murine uterus.
Wegener
Jörg W
JW
Institute of Pharmacology and Toxicology, Technische Universität München, Biedersteiner Strasse 29, 80202 Munich, Germany. Wegener@ipt.med.tu-muenchen.de
Lee
Matthias
M
Hofmann
Franz
F
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D020746:Calcium Channels, L-Type / Q000378:metabolism; D002454:Cell Differentiation / Q000502:physiology; D004095:Dihydropyridines / Q000494:pharmacology*; D005260:Female; D007037:Hypothyroidism / Q000503:physiopathology*; D066298:In Vitro Techniques; D017275:Isradipine / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D013963:Thyroid Hormones / Q000097:blood; D014590:Uterine Contraction / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects* / Q000502:physiology
D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D004095:Dihydropyridines; D013963:Thyroid Hormones; C038806:1,4-dihydropyridine; D017275:Isradipine