Temporal relationship of muscle weakness and pain reduction in subjects treated with botulinum toxin A.
Botulinum toxin A has demonstrated efficacy in relieving pain in spastic and nonspastic muscle conditions. This analgesic property has generally been attributed to muscular relaxation. This study demonstrates initial muscular relaxation and concomitant pain relief in a masticatory muscle model. However, as muscle power returns to normal, pain relief is still very evident. This result suggests that the analgesic effect attributed to botulinum toxin is more complex than simple muscular relaxation.
Freund
Brian
B
Faculty of Dentistry, University of Toronto, Toronto, Canada. brian.freund@utoronto.ca
Schwartz
Marvin
M
D000293:Adolescent; D000328:Adult; D001732:Bite Force; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009126:Muscle Relaxation / Q000187:drug effects*; D018908:Muscle Weakness / Q000188:drug therapy* / Q000209:etiology; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D011446:Prospective Studies; D013705:Temporomandibular Joint Disorders / Q000150:complications*; D013997:Time Factors
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A