title: Absolute configuration and anticancer activity of taxiresinol and related lignans of Taxus wallichiana.
abstract: Absolute configuration of taxiresinol 1, a lignan from the heartwood of Taxus wallichiana has been determined as 8R, 8'R, and 7'R with the help of chemical correlation method and X-ray crystallography. The anticancer activity of taxiresinol 1 and other two lignans 2, 3 were also studied. Taxiresinol 1 showed notable anticancer activity in the in vitro bioassays against colon, liver, ovarian and breast cancer cell lines.
authors: Central Institute of Medicinal and Aromatic Plants (CIMAP), PO CIMAP, -226 015, Lucknow, India. chattsk@yahoo.com
authors: Sunil K
authors: SK
authors: Chattopadhyay
authors: T R Santha
authors: TR
authors: Kumar
authors: Prakas R
authors: PR
authors: Maulik
authors: Sachin
authors: S
authors: Srivastava
authors: Ankur
authors: A
authors: Garg
authors: Ashoke
authors: A
authors: Sharon
authors: Arvind S
authors: AS
authors: Negi
authors: Suman Preet S
authors: SP
authors: Khanuja
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D020946:Taxus / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005663:Furans; D017705:Lignans; D010936:Plant Extracts; C483062:taxiresinol