Tumor chemopreventive activity of 3-O-acylated (--)-epigallocatechins.
In order to seek promising cancer chemopreventive agents, we assessed the antitumor promoting activities of 3-O-octanoyl- or 3-O-(2-methyloctanoyl)-(--)-epigallocatechins, inhibiting markedly the activation of Epstein-Barr virus early antigen, in a two-stage mouse skin carcinogenesis assay. As a result, these derivatives inhibited a papilloma formation 1.3-1.6-fold more strongly than (--)-epigallocatechin gallate well established as anti-tumor promoter.
Kumagai
Ayako
A
Department of Biotechnology, Faculty of Engineering, Kansai University, Suita, Osaka 564-8680, Japan.
Nagaoka
Yasuo
Y
Obayashi
Tomoko
T
Terashima
Yasuhiro
Y
Tokuda
Harukuni
H
Hara
Yukihiko
Y
Mukainaka
Teruo
T
Nishino
Hoyoku
H
Kuwajima
Hiroshi
H
Uesato
Shinichi
S
D000215:Acylation; D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010212:Papilloma / Q000517:prevention & control*; D012878:Skin Neoplasms / Q000517:prevention & control*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
D016588:Anticarcinogenic Agents; D002392:Catechin; C057580:gallocatechol