title: Role of the Nh (Non-hair) mutation in the development of dermatitis and hyperproduction of IgE in DS-Nh mice.
abstract: The DS-Nh (DS Non-hair) mouse is a spontaneous hairless mutant of the DS mouse. The inheritance mode of the Nh mutation is autosomal dominant, and the Nh locus is mapped to Chromosome 11. The roles of the Nh mutation in spontaneous dermatitis and IgE hyperproduction were studied using an Nh congenic strain with a genetic background from the BALB/c mouse. In contrast to DS-Nh (Nh/+) mice, BALB/c-Nh (Nh/+) mice under conventional conditions showed a marked increase in serum IgE, without the development of dermatitis. These results suggest that IgE hyperproduction is regulated by the Nh mutation, while other genetic factor(s) are also involved in the development of dermatitis.
authors: Developmental Research Laboratories, Shionogi & Co., Ltd., Toyonaka, Japan.
authors: Akira
authors: A
authors: Watanabe
authors: Mitsuo
authors: M
authors: Takeuchi
authors: Masafumi
authors: M
authors: Nagata
authors: Kazuichi
authors: K
authors: Nakamura
authors: Hiroyuki
authors: H
authors: Nakao
authors: Hirofumi
authors: H
authors: Yamashita
authors: Susumu
authors: S
authors: Makino
authors: Minoru
authors: M
authors: Harada
authors: Tsutomu
authors: T
authors: Hirasawa
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D003872:Dermatitis / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D051379:Mice; D008812:Mice, Hairless / Q000235:genetics*; D008807:Mice, Inbred BALB C; D008817:Mice, Mutant Strains / Q000235:genetics*; D009154:Mutation
chemical_list: D007073:Immunoglobulin E