title: Urethral injection for stress urinary incontinence: long-term results with dextranomer/hyaluronic acid copolymer.
abstract: Urethral injection is a convenient, minimally invasive means of treating stress urinary incontinence (SUI). We present long-term follow-up data from 20 patients originally recruited in 1994-95 (mean age 67 years) to receive urethral injection with dextranomer/hyaluronic acid (Dx/HA) copolymer. The majority of patients had failed previous therapy for SUI. If the first injection was unsuccessful, up to two further injections were offered. Only 3 patients (15%) failed to show a response to treatment. Sixteen women were reassessed during 2001 (4 had died of causes unrelated to the study treatment). A sustained response throughout the follow-up period was reported in 9/16 patients (57%), with incontinence recurring in just 4 (25%). None of the 7 patients with persistent or recurrent incontinence were cured by subsequent treatments, including surgery. In conclusion, urethral injection with Dx/HA copolymer offers promising long-term efficacy in the treatment of SUI, regardless of old age or failure to respond to previous therapy.
authors: Department of Gynecology, Enköping Hospital, Box 908, SE-745 25 Enköping, Sweden. asa.stenberg@kc.le.lul.se
authors: A M
authors: AM
authors: Stenberg
authors: G
authors: G
authors: Larsson
authors: P
authors: P
authors: Johnson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials / Q000008:administration & dosage*; D003911:Dextrans / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage*; D007267:Injections; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D014521:Urethra; D014550:Urinary Incontinence, Stress / Q000628:therapy*
chemical_list: D001672:Biocompatible Materials; D003911:Dextrans; C013471:dextranomer; D006820:Hyaluronic Acid