Cerebellar ataxia and leukoencephalopathy associated with cobalamin deficiency.
We report a patient who presented progressive cerebellar ataxia associated with vitamin B(12) deficiency. Brain magnetic resonance imaging (MRI) demonstrated a diffuse leukoencephalopathy. Six months after the initiation of methylcobalamin therapy, there were clinical improvement and reduction in the MRI abnormalities.
Morita
Shuhei
S
Department of Neurology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, Wakayama 641-8510, Japan.
Miwa
Hideto
H
Kihira
Tameko
T
Kondo
Tomoyoshi
T
D001933:Brain Stem / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D002524:Cerebellar Ataxia / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D002531:Cerebellum / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D015140:Dementia, Vascular / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005290:Ferric Compounds / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000378:metabolism / Q000473:pathology; D020127:Recovery of Function / Q000187:drug effects; D016896:Treatment Outcome; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014806:Vitamin B 12 Deficiency / Q000150:complications* / Q000188:drug therapy
D005290:Ferric Compounds; C000499:ferric oxide; C019476:mecobalamin; D014805:Vitamin B 12