title: Comparison of quantitative 99mTc-HMPAO and 67Ga citrate lung scans in patients with active diffuse infiltrative lung disease.
abstract: Diffuse infiltrative lung disease (ILD) is a heterogeneous group of disorders that predominantly affect the lung parenchyma and spare the airway. To objectively assess the degree of pulmonary vascular endothelium damage in active ILD, lung/liver uptake ratios (L/L ratios) on 99mTc hexamethylpropylene amine oxime (99mTc-HMPAO) lung scans were determined in 21 patients with active ILD. Meanwhile, the 67Ga citrate uptake index (GUI) on 67Ga lung scans was measured in order to evaluate the severity of lung inflammation in active ILD. The results show there were statistically significant differences between normal controls and patients with active ILD, as shown in the L/L ratio and GUI. However, when the patients were divided into two groups: (1) eight patients with normal chest X-ray findings, and (2) 13 patients with abnormal X-ray findings, there was no significant difference between groups 1 and 2 for the results of L/L ratio and GUI. In addition, no correlation between the degree of damage to the pulmonary vascular endothelium and the severity of lung inflammation was found. In conclusion, L/L ratios on 99mTc-HMPAO lung scans and GUI on 67Ga lung scans are different to the findings of chest X-rays and have the potential to objectively detect the degree of damage to the pulmonary vascular endothelium and the severity of lung inflammation in active IDL. However, the relationship between L/L ratio and GUI in active ILD is not significant.
authors: Department of Nuclear Medicine, Far Eastern Memorial Hospital, Taipei, Taiwan.
authors: F Y
authors: FY
authors: Liu
authors: Y C
authors: YC
authors: Shiau
authors: A
authors: A
authors: Kao
authors: W H
authors: WH
authors: Hsu
authors: J J
authors: JJ
authors: Wang
authors: C H
authors: CH
authors: Tsai
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D002951:Citrates; D005260:Female; D005708:Gallium; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D019690:Technetium Tc 99m Exametazime
chemical_list: D002951:Citrates; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D005708:Gallium; C103850:gallium citrate