The odd couple: signal transduction and endocytosis.
Cell surface receptors are used to transmit extracellular information. The activation of cell surface receptors initiates signal transduction and receptor endocytosis. Signal transduction and the endosomal transport of activated receptors require precise regulation. New concepts for the integration of endocytosis and signaling arise from recent findings that suggest bidirectional interplay of these two processes. This review discusses the following questions: (i) do activated cell surface receptors modify the endosomal system to promote internalization and endosomal traffic, and (ii) do internalized cell surface receptors use specifically localized signaling complexes to generate specific biological signals?
Teis
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Institute of Anatomy, Histology and Embryology, Department of Histology and Molecular Cell Biology, University of Innsbruck, Muellerstrasse 59, 6020 Innsbruck, Austria. david.teis@uibkac.at
Huber
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D000818:Animals; D004705:Endocytosis / Q000502:physiology*; D011992:Endosomes / Q000502:physiology; D006801:Humans; D008247:Lysosomes / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D011956:Receptors, Cell Surface; D020794:Receptor Protein-Tyrosine Kinases