[Ninety-day dietary toxicity study of mulberry leaf extract in rats].
Mulberry leaf extract was studied toxicologically in male and female SD rats. The extract was administered orally at concentrations of 0% (control group), 0.1%, 0.4% and 1% in basal diet for 90 days. No remarkable change in test animals of both sexes was observed in terms of body weight gain or at necropsy. Hematology and blood chemistry revealed no abnormalities. Pathological examination revealed no toxic change in any organ observed. These findings indicate that dietary intake of 1% mulberry leaf extract for 90 days (884.5 mg/kg/day for males and 995.7 mg/kg/day for females as mean daily intake) causes no toxicological change in rats.
Miyazawa
Maki
M
Kanagawa Prefectural Institute of Public Health: 1-3-1, Shimomachiya, Chigasaki-shi, Kanagawa 253-0087, Japan.
Miyahara
Chieko
C
Satoh
Shuji
S
Sakai
Anri
A
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D006403:Hematologic Tests; D008297:Male; D031625:Morus; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D010936:Plant Extracts