title: [Sequelae of hypertension on end-organs of the brain].
abstract: Hypertension is the most important risk factor for stroke and vascular dementia. Antihypertensive treatment reduces stroke risk by 40%. Most probably all antihypertensive drugs are equally effective with the exception of alpha-blockers. Blood pressure is increased in many patients with acute stroke. In this phase sudden drops in blood pressure should be avoided. The combination of an ACE-inhibitor and a diuretic reduced strokes by 28% after TIA or a first stroke. Whether this is a drug specific effect or due to lowering blood pressure per se is investigated at the moment.
authors: Neurologische Universitätsklinik Essen. h.diener@uni-essen.de
authors: H C
authors: HC
authors: Diener
authors: Th
authors: T
authors: Philipp
authors: J
authors: J
authors: Schrader
mesh_terms: D000959:Antihypertensive Agents / Q000145:classification* / Q000627:therapeutic use*; D001794:Blood Pressure; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D012307:Risk Factors; D011984:Sensory Receptor Cells / Q000503:physiopathology; D020521:Stroke / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents