Rat model of borna disease virus transmission: epidemiological implications.
Rapid transmission of Borna disease virus occurred upon cohabitation of persistently infected and naive rats. Infectious virus, which was abundantly present in fresh urine samples of carrier rats, entered the brains of recipient rats via the olfactory route. Thus, susceptible farm animals possibly acquire the virus from persistently infected rats.
Sauder
Christian
C
Department of Virology, University of Freiburg, D-79104 Freiburg, Germany. Sauder@cber.FDA.gov
Staeheli
Peter
P
D000818:Animals; D001890:Borna Disease / Q000453:epidemiology / Q000635:transmission*; D001891:Borna disease virus / Q000302:isolation & purification*; D002353:Carrier State; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051381:Rats; D014556:Urine / Q000821:virology