A short and efficient synthesis of crocetin-dimethylester and crocetindial.
In this paper we describe an efficient six-step synthesis of crocetin-dimethylester that could be further reduced to a "four-step" synthesis through the use of in situ procedures. The simplicity of the whole process, the ready availability of starting materials, and the high overall yield render this strategy a very attractive synthesis of this very important compound, which is the key intermediate for the synthesis of several carotenoids and other polyene natural products.
Frederico
Daniel
D
Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, 14040-901 Ribeirão Preto, SP, Brazil.
Donate
Paulo Marcos
PM
Constantino
Mauricio Gomes
MG
Bronze
Erika Soares
ES
Sairre
Mirela I
MI