title: Glycoxidation and inflammation in chronic haemodialysis patients.
abstract: BACKGROUND
  Uraemia and haemodialysis treatment are associated with microinflammation and oxidative as well as carbonyl stress, which result in enhanced formation of glycoxidation products. Although both glycoxidation and inflammation can contribute to severe vascular and cardiovascular complications, the role that these pathogenic mechanisms play in the complex response of the whole organism remains to be elucidated.
  
  
  METHODS
  We performed a cross-sectional study in 34 clinically stable chronic haemodialysis patients and in 14 healthy controls while determining serum concentrations of pentosidine, fluorescent advanced glycation end-products (AGEs), advanced oxidation protein products (AOPPs) and acute phase reactants. We further assessed the relationship between these glycoxidation products and parameters of inflammation.
  
  
  RESULTS
  Glycoxidation products as well as certain acute phase reactants were elevated in haemodialysis patients. There were significant correlations between AOPPs and inflammatory parameters such as orosomucoid (0.39, P < 0.05), fibrinogen (0.49, P < 0.05) and pregnancy-associated protein A (PAPP-A; 0.46, P < 0.05), but no correlations between pentosidine or fluorescent AGEs and any of the inflammatory parameters.
  
  
  CONCLUSIONS
  Oxidative damage showed a closer relationship to inflammation than advanced glycation (glycoxidation). AOPPs may represent a superior acute biochemical marker, whereas AGEs may better describe chronic long-lasting damage.
authors: Institute of Medical Biochemistry, Department of Medicine Strahov, First Faculty of Medicine, Charles University and General University Hospital, Katerinská 32, CZ 121 08 Prague 2, Czech Republic.
authors: Marta
authors: M
authors: Kalousová
authors: Sylvie
authors: S
authors: Sulková
authors: Lenka
authors: L
authors: Fialová
authors: Jirina
authors: J
authors: Soukupová
authors: Ivan Matous
authors: IM
authors: Malbohan
authors: Pavel
authors: P
authors: Spacek
authors: Martin
authors: M
authors: Braun
authors: Ludmila
authors: L
authors: Mikulíková
authors: Magdaléna
authors: M
authors: Fortová
authors: Magdaléna
authors: M
authors: Horejsí
authors: Vladimír
authors: V
authors: Tesar
authors: Tomás
authors: T
authors: Zima
mesh_terms: D000209:Acute-Phase Proteins / Q000276:immunology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood / Q000276:immunology*; D006031:Glycosylation; D006801:Humans; D007154:Immune System Diseases / Q000276:immunology* / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000276:immunology / Q000502:physiology*; D006435:Renal Dialysis / Q000009:adverse effects*
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; D017127:Glycation End Products, Advanced