title: Comparison of four different suture materials in soft tissues of rats.
abstract: OBJECTIVE
  The purpose of this in vivo study was to histopathologically evaluate the inflammatory reaction incited by Vicryl in rats and compare this material with various suture materials that are widely used in the clinic.
  
  
  METHODS
  Four different suture materials, catgut, silk, polypropylene, and Vicryl were used in soft tissues of 32 Sprague-Dawley rats. Incisions performed were sutured by a standard technique. Eight rats were killed at the first, third, fifth, and seventh days. Histopathological evaluation of the en bloc samples was performed by determining the density of seven cell-types. A numerical grading from one to three was used. The data were statistically analysed by Kruskal-Wallis one way ANOVA and Dunn's tests.
  
  
  RESULTS
  Vicryl has produced the mildest tissue reaction among the test materials at all experimental periods (P<0.05). Total cell number value in Vicryl group was found to be significantly lower than the one in catgut group (P<0.05).
  
  
  CONCLUSIONS
  Under the conditions of this study, the results demonstrated that Vicryl as a suture material produced the mildest tissue reaction during early healing period.
authors: Department of Oral Surgery and Medicine, Faculty of Dentistry, Istanbul University, Capa, Istanbul, Turkey. myaltrk@yahoo.com
authors: M
authors: M
authors: Yaltirik
authors: K
authors: K
authors: Dedeoglu
authors: B
authors: B
authors: Bilgic
authors: M
authors: M
authors: Koray
authors: H
authors: H
authors: Ersev
authors: H
authors: H
authors: Issever
authors: O
authors: O
authors: Dulger
authors: S
authors: S
authors: Soley
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D012831:Bombyx; D002398:Catgut; D002452:Cell Count; D007249:Inflammation / Q000473:pathology; D019476:Insect Proteins / Q000737:chemistry; D008297:Male; D011098:Polyglactin 910 / Q000737:chemistry; D011126:Polypropylenes / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D047011:Silk; D012867:Skin / Q000473:pathology*; D018709:Statistics, Nonparametric; D013537:Sutures; D013997:Time Factors; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D019476:Insect Proteins; D011126:Polypropylenes; D047011:Silk; D011098:Polyglactin 910