title: Clinical evaluation of an enamel matrix derivative in the treatment of mandibular degree II furcation involvement: a 36-month case series.
abstract: The aim of the present study was to evaluate the clinical outcome following application of an enamel matrix derivative in degree II mandibular furcation involvements. Ten patients with chronic periodontitis, presenting a total of eight buccal and eight lingual degree II furcation involvements, were included in the study. The following clinical parameters were evaluated prior to treatment and after 6, 12, and 36 months: probing attachment level in horizontal direction in the buccal and/or lingual furcation area (PAL-H) and probing attachment level in vertical direction (PAL-V) at the center of the buccal/lingual furcation area. The postoperative healing phase was uneventful in all cases, and no complications were observed throughout the entire study period. At 6 months, the mean PAL-H of the buccal defects was reduced from 4.0 +/- 1.3 mm to 2.6 +/- 1.4 mm, and the mean PAL-V was reduced from 5.2 +/- 2.0 mm to 4.0 +/- 1.6 mm. At the lingual defects, the mean PAL-H was reduced from 3.6 +/- 1.3 mm to 3.1 +/- 1.1 mm, and the mean PAL-V was reduced from 5.6 +/- 2.0 mm to 4.3 +/- 1.8 mm. At 12 and 36 months, clinical parameters remained similar, without any further clinical improvement. These results suggest that the treatment of degree II mandibular furcation involvements with enamel matrix derivative might lead to clinical improvement. However, controlled clinical trials and histologic studies are needed to examine the clinical significance of these results and the characteristics of healing following application of enamel matrix derivative.
authors: Department of Periodontology, Royal Dental College, University of Aarhus, Denmark. N.Donos@eastman.ucl.ac.uk
authors: Nikolaos
authors: N
authors: Donos
authors: Leif
authors: L
authors: Glavind
authors: Thorkild
authors: T
authors: Karring
authors: Anton
authors: A
authors: Sculean
mesh_terms: D000328:Adult; D000368:Aged; D001861:Bone Regeneration / Q000187:drug effects*; D003746:Dental Enamel Proteins / Q000494:pharmacology*; D017823:Furcation Defects / Q000601:surgery*; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D008567:Membranes, Artificial; D008875:Middle Aged; D008963:Molar; D010512:Periodontal Index; D011138:Polytetrafluoroethylene; D018709:Statistics, Nonparametric; D013357:Subgingival Curettage
chemical_list: D003746:Dental Enamel Proteins; D008567:Membranes, Artificial; C109069:enamel matrix proteins; D011138:Polytetrafluoroethylene