Liver transplantation for fulminant liver failure in children.
The mortality rate of fulminant hepatic failure (FHF) in childhood has remained between 70% and 95% despite recent improvements in medical therapy. Liver transplantation has become an important therapeutic option in adults with this entity, but has been infrequently performed in children. Many children do not receive transplants because of the rapid progression of the illness and the lack of suitable donor livers. We present our experience in liver transplantation in children with FHF. Between March 1988 and December 1989, seven children aged between 15 months and 12 years received eight liver transplants. The aetiology of FHF was viral hepatitis in five and drug hepatotoxicity (carbamazepine) in two. Five of our patients were in grade III-IV coma. Reduced-sized livers were used in six of the eight transplants. The post-operative morbidity included viral and fungal infections, and abdominal bleeding. Two patients died from graft-versus-host disease and one from brain aspergillosis. Four patients (57%) survived a median follow-up of 15 months. Liver transplantation should be the therapeutic option in children with FHF where the chances of medical recovery are poor.
Mondragon
R
R
Department of Surgery, King's College Hospital and King's College School of Medicine and Dentistry, London, UK.
Mieli-Vergani
G
G
Heaton
N D
ND
Mowat
A P
AP
Vougas
V
V
Williams
R
R
Tan
K C
KC
D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D006498:Hepatectomy / Q000379:methods; D006501:Hepatic Encephalopathy / Q000209:etiology / Q000601:surgery; D006801:Humans; D007223:Infant; D017093:Liver Failure / Q000601:surgery*; D016031:Liver Transplantation / Q000379:methods*; D012086:Reoperation; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors