Treadmill exercise decreases intrastriatal hemorrhage-induced neuronal cell death via suppression on caspase-3 expression in rats.
Intracerebral hemorrhage is one of the most devastating types of stroke. This disease is known to cause severe neurological damage and also has a very high mortality rate. In this study, the effect of treadmill exercise on intrastriatal hemorrhage-induced neuronal cell death was investigated. Intrastriatal hemorrhage was caused by injection of collagenase into the striatum using a stereotaxic instrument. Animals of the exercise group were made to run on a treadmill for 30 min once a day during 10 consecutive days. In the present results, treadmill exercise was shown to suppress the increase in the size of hemorrhage-induced lesions and the increase in caspase-3 expression in the striatum. Based on these results, it is possible that treadmill exercise aids in the recovery from central nervous system sequelae following intracerebral hemorrhage.
Lee
Hee-Hyuk
HH
Department of Physiology, College of Medicine, Kyung Hee University, # 1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea.
Kim
Hong
H
Lee
Myoung-Hwa
MH
Chang
Hyun-Kyung
HK
Lee
Taeck-Hyun
TH
Jang
Mi-Hyeon
MH
Shin
Min-Chul
MC
Lim
Baek-Vin
BV
Shin
Mal-Soon
MS
Kim
Young-Pyo
YP
Yoon
Jin-Hwan
JH
Jeong
Il-Gyu
IG
Kim
Chang-Ju
CJ
D000818:Animals; D053148:Caspase 3; D061945:Caspase Inhibitors; D020169:Caspases / Q000096:biosynthesis* / Q000502:physiology; D016923:Cell Death / Q000502:physiology; D002543:Cerebral Hemorrhage / Q000201:enzymology* / Q000473:pathology / Q000517:prevention & control; D003342:Corpus Striatum / Q000201:enzymology* / Q000473:pathology; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology; D008297:Male; D009474:Neurons / Q000201:enzymology* / Q000473:pathology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D061945:Caspase Inhibitors; C505410:Casp3 protein, rat; D053148:Caspase 3; D020169:Caspases