The phosphotransferase system of Streptomyces coelicolor is biased for N-acetylglucosamine metabolism.
Mutation of the crr-ptsI gene locus revealed that Streptomyces coelicolor uses the phosphotransferase system (PTS) for N-acetylglucosamine uptake. crr, ptsI, and ptsH, which encode the three general PTS phosphotransferases, are induced by N-acetylglucosamine but not by other PTS substrates. Thus, the S. coelicolor PTS is biased for N-acetylglucosamine utilization, a novel feature that distinguishes this PTS from others.
Nothaft
Harald
H
Lehrstuhl für Mikrobiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, D-91058 Erlangen, Germany.
Dresel
Dagmar
D
Willimek
Andreas
A
Mahr
Kerstin
K
Niederweis
Michael
M
Titgemeyer
Fritz
F
D000117:Acetylglucosamine / Q000378:metabolism*; D005798:Genes, Bacterial; D009154:Mutation; D010770:Phosphotransferases / Q000235:genetics / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism*; D013379:Substrate Specificity
D010770:Phosphotransferases; D000117:Acetylglucosamine