The regulation of lupus-associated autoantibodies: immunoglobulin transgenic models.
Several advances have been made regarding the regulation of lupus-associated autoantibodies, including the identification of factors that lead to their production in autoimmunity. Recent studies have further defined the receptor-editing mechanisms used to eliminate autoreactive B cells, and have shown that these may be altered in autoimmune mice. In addition, evidence that autoreactive B cells persisting in the periphery can be activated by both T-dependent and T-independent stimuli suggests potential pathways by which autoantibodies may arise in lupus.
Fields
Michele L
ML
The Wistar Institute, Room 276, 3601 Spruce Street, Philadelphia, PA 19104, USA.
Erikson
Jan
J
D000818:Animals; D001323:Autoantibodies / Q000235:genetics / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D004247:DNA / Q000276:immunology; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D051379:Mice; D008822:Mice, Transgenic
D001323:Autoantibodies; D004247:DNA