[Estimation of maximum acceptable concentration of lead and cadmium in plants and their medicinal preparations].
Heavy metals (lead, cadmium) are possible dashes which quantity is defined by the limiting acceptable contents. Different drugs preparations: infusions, decoctions, tinctures, extracts, etc. are produced using medicinal plants. The objective of this research was to study the impurities of heavy metals (lead, cadmium) in medicinal plants and some drug preparations.


METHODS
We investigated liquid extracts of fruits Crataegus monogyna Jacq. and herbs of Echinacea purpurea Moench., tinctures--of herbs Leonurus cardiaca L. The raw materials were imported from Poland. Investigations were carried out in cooperation with the Laboratory of Antropogenic Factors of the Institute for Biomedical Research. Amounts of lead and cadmium were established after "dry" mineralisation using "Perkin-Elmer Zeeman/3030" model electrothermic atomic absorption spectrophotometer (ETG AAS/Zeeman). It was established that lead is absorbed most efficiently after estimation of absorption capacity of cellular fibers. About 10.73% of lead crosses tinctures and extracts, better cadmium--49.63%. Herbs of Leonurus cardiaca L. are the best in holding back lead and cadmium. About 14.5% of lead and cadmium crosses the tincture of herbs Leonurus cardiaca L. We estimated the factors of heavy metals (lead, cadmium) in the liquid extracts of Crataegus monogyna Jacq. and Echinacea purpurea Moench., tincture of Leonurus cardiaca L. after investigations of heavy metals (lead, cadmium) in drugs and preparations of it. The amounts of heavy metals (lead, cadmium) don't exceed the allowable norms in fruits of Crataegus monogyna Jacq., herbs of Leonurus cardiaca L. and Echinacea purpurea Moench. after estimation of lead and cadmium extraction factors, the maximum of acceptable daily intake and the quantity of drugs consumption in day.
Zitkevicius
Virgilijus
V
Department of Pharmaceutical Chemistry and Pharmacognosy, Kaunas University of Medicine, Kaunas, Lithuania.
Savickiene
Nijole
N
Abdrachmanovas
Olegas
O
Ryselis
Stanislovas
S
Masteiková
Rūta
R
Chalupova
Zuzana
Z
Dagilyte
Audrone
A
Baranauskas
Algirdas
A
D002104:Cadmium / Q000032:analysis*; D027825:Crataegus / Q000737:chemistry*; D020900:Echinacea / Q000737:chemistry*; D006801:Humans; D007854:Lead / Q000032:analysis*; D031332:Leonurus / Q000737:chemistry*; D008452:Maximum Allowable Concentration; D008956:Models, Chemical; D010936:Plant Extracts / Q000737:chemistry*; D013054:Spectrophotometry, Atomic
D010936:Plant Extracts; D002104:Cadmium; D007854:Lead