title: Pineal parenchymal tumor with marked retinoblastic differentiation: case report.
abstract: A 53-year-old woman was found to have a tumor in the pineal region. Histologically, Homer-Wright rosettes were sporadically distributed in a diffuse proliferation of round tumor cells that were immunoreactive for synaptophysin and chromogranin. A few perivascular pseudorosettes were also present, and the perivascular tumor cells were immunoreactive for glial fibrillary acidic protein and vimentin. By electron microscopy, well-developed junctions and pronounced interdigitation of abutting plasma membranes were noted in many tumor cells, as well as abundant intracytoplasmic microtubules. These findings indicated that the tumor was a pineal parenchymal tumor accompanied by an extraordinary epithelial-like differentiation, suggesting retinoblastic photoreceptor cell differentiation.
authors: Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa 228-8555, Japan. utsuki@med.kitasato-u.ac.jp
authors: Satoshi
authors: S
authors: Utsuki
authors: Nobuyuki
authors: N
authors: Kawano
authors: Hidehiro
authors: H
authors: Oka
authors: Yutaka
authors: Y
authors: Fukushima
authors: Koji
authors: K
authors: Kondo
authors: Yoshinori
authors: Y
authors: Tanizaki
authors: Yoshie
authors: Y
authors: Yashui
authors: Kiyotaka
authors: K
authors: Fujii
authors: Saburo
authors: S
authors: Yagishita
mesh_terms: D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D002454:Cell Differentiation; D003937:Diagnosis, Differential; D004806:Ependymoma / Q000473:pathology; D004847:Epithelial Cells / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008854:Microscopy, Electron; D008875:Middle Aged; D010870:Pineal Gland / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D010871:Pinealoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D012175:Retinoblastoma / Q000473:pathology