title: Treatment of venous malformations with sclerosant in microfoam form.
abstract: BACKGROUND
  Treatment of congenital venous malformations poses a major clinical challenge. Surgery is difficult and frequently unsuccessful, radiological intervention with embolization has an ill-defined role, and conventional sclerotherapy has little to offer.
  
  
  OBJECTIVE
  To evaluate the efficacy and safety of sclerosant in microfoam form in treating congenital venous malformations.
  
  
  METHODS
  A retrospective study of medical records, pretreatment and posttreatment color photographs, echo-Doppler ultrasonographic results, and/or magnetic resonance imaging in patients with congenital vascular malformations of venous predominance. Follow-up ranged from 6 to 103 months (mean, 30 months).
  
  
  METHODS
  Private vascular surgery clinic in Granada, Spain, and dermatology department at a university hospital in Pamplona. Patients The study population comprised 50 patients, 19 with limited venous malformations, 16 with infiltrating venous malformations, and 15 with Klippel-Trénaunay syndrome.Intervention Percutaneous sclerotherapy by direct injection of 0.25% to 4% polidocanol microfoam under du-plex ultrasonographic guidance. The number of sessions varied between 1 and 46 (mean, 12 sessions).
  
  
  METHODS
  The primary efficacy end point was defined as a reduction in size after completion of the treatment.
  
  
  RESULTS
  Sclerosis therapy with polidocanol microfoam was judged beneficial in 46 (92%) of the 50 patients. Among the 46 responders, 18 showed disappearance of treated malformations, 15 showed a reduction in malformation size of more than 50%, and 13 showed a reduction in malformation size of 50% or less. Of the 39 patients who presented with pain, the pain disappeared in 25 and was reduced in 14. No major adverse effects were reported by any patient. There were 4 cases of transient skin pigmentation and 3 cases of skin necrosis.
  
  
  CONCLUSIONS
  Color echo-Doppler ultrasonography-guided sclerotherapy with polidocanol microfoam was effective in 46 (92%) of the patients. The technique is delivered on a strictly ambulatory basis and has proved simple and innocuous. The quality and durability of the outcome make this novel procedure the treatment of choice in the care of patients with congenital venous malformations.
authors: Vascular Surgery Clinic, Granada, Spain.
authors: Juan
authors: J
authors: Cabrera
authors: Juan
authors: J
authors: Cabrera
authors: Ma Antonia
authors: MA
authors: Garcia-Olmedo
authors: Pedro
authors: P
authors: Redondo
mesh_terms: D000293:Adolescent; D000328:Adult; D000388:Air; D005260:Female; D006801:Humans; D007715:Klippel-Trenaunay-Weber Syndrome / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008863:Microspheres; D000077423:Polidocanol; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D012189:Retrospective Studies; D012597:Sclerosing Solutions / Q000008:administration & dosage*; D016896:Treatment Outcome; D018615:Ultrasonography, Doppler, Color; D014680:Veins / Q000002:abnormalities* / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology
chemical_list: D012597:Sclerosing Solutions; D000077423:Polidocanol; D011092:Polyethylene Glycols