Neutropenic colitis with cecal perforation during antithyroid therapy.
Neutropenic colitis, characterized by neutropenia plus cecal and ascending colon inflammation, is a rare complication of chemotherapy in hematological malignancies and, less commonly, of medication used to treat other diseases (e.g., hyperthyroidism). We report a case of neutropenic colitis with cecal perforation in a 44-year-old woman treated with methimazole for hyperthyroidism. The patient had received subtotal thyroidectomy for hyperthyroidism in 1984 and recurrent hyperthyroidism was found in 1993. She was then treated with methimazole for almost 3 months, when sustained fever, diarrhea, weakness, and progressive abdominal pain developed. Due to the findings of peritonitis and neutropenia, she underwent emergent laparotomy. During the operation, chronic ulceration of the cecum with perforation was found and resection of the ileocecal segment and ileostomy were performed. Three months later, closure of the ileostomy with anastomosis of the ileocolostomy was performed. Her condition was stable during 9 years' follow-up. In conclusion, neutropenic enterocolitis has a broad spectrum of clinical presentations that require alertness in patients with neutropenia. When detected late, it may lead to bowel perforation and even mortality.
Chen
Der-Fang
DF
Division of General Surgery, Department of Surgery, Cathay General Hospital, Taipei, Taiwan.
Chao
Ing-Ming
IM
Huang
Shi-Hsin
SH
D000328:Adult; D013956:Antithyroid Agents / Q000009:adverse effects*; D002429:Cecal Diseases / Q000139:chemically induced* / Q000601:surgery; D003092:Colitis / Q000139:chemically induced* / Q000601:surgery; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D007416:Intestinal Perforation / Q000139:chemically induced* / Q000601:surgery; D008713:Methimazole / Q000009:adverse effects*; D009503:Neutropenia / Q000139:chemically induced*
D013956:Antithyroid Agents; D008713:Methimazole