The role of cell cycle proteins in Glomerular disease.
Although initially identified and characterized as regulators of the cell cycle and hence proliferation, an extended role for cell cycle proteins has been appreciated more recently in a number of physiologic and pathologic processes, including development, differentiation, hypertrophy, and apoptosis. Their precise contribution to the cellular response to injury appears to be dependent on both the cell type and the nature of the initiating injury. The glomerulus offers a remarkable situation in which to study the cell cycle proteins, as each of the 3 major resident cell types (the mesangial cell, podocyte, and glomerular endothelial cell) has a specific pattern of cell cycle protein expression when quiescent and responds uniquely after injury. Defining their roles may lead to potential therapeutic strategies in glomerular disease.
Griffin
Siân V
SV
Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Pichler
Raimund
R
Wada
Takehiko
T
Vaughan
Michael
M
Durvasula
Raghu
R
Shankland
Stuart J
SJ
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism* / Q000502:physiology; D002455:Cell Division; D002478:Cells, Cultured; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D005920:Glomerular Mesangium / Q000166:cytology / Q000378:metabolism; D005921:Glomerulonephritis / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism* / Q000502:physiology; D011379:Prognosis; D012680:Sensitivity and Specificity
D018797:Cell Cycle Proteins; D018844:Cyclin-Dependent Kinases