title: [A case of successful treatment of advanced hepatocellular carcinoma with tumor thrombi in the major portal branches and inferior vena cava with combined intraarterial 5-fluorouracil, adriamycin and cisplatin therapy].
abstract: The patient is a 75-year-old male. Abdominal ultrasound tomography in June 2002 revealed hepatocellular carcinoma with intrahepatic metastasis (IM3) and tumor thrombi (Vp4, Vv3) at S4 in the major portal and hepatic vein. From July 2002, he received hepatic arterial infusion therapy (FAP: 5-fluorouracil, CDDP and adriamycin) for these lesions. In December 2002, these lesions had disappeared completely after 6 sessions of arterial infusion therapy. The patient is still alive with no recurrence after 2 years since the beginning of this treatment. Recently, we treated 9 patients with combined arterial infusion chemotherapy (FAP), and the response rate (CR and PR) was 44% and no major side effect was observed. In conclusion, some patients may obtain longer survival through this treatment, even in cases of advanced HCC with tumor thrombus in the major trunks of portal vein and/or hepatic vein.
authors: Dept. of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University.
authors: Hideo
authors: H
authors: Ota
authors: Hiroaki
authors: H
authors: Nagano
authors: Masato
authors: M
authors: Sakon
authors: Tameyoshi
authors: T
authors: Yamamoto
authors: Masato
authors: M
authors: Nakamura
authors: Shigeru
authors: S
authors: Marubashi
authors: Atsushi
authors: A
authors: Miyamoto
authors: Keizo
authors: K
authors: Dono
authors: Koji
authors: K
authors: Umeshita
authors: Shoji
authors: S
authors: Nakamori
authors: Takamichi
authors: T
authors: Murakami
authors: Hironobu
authors: H
authors: Nakamura
authors: Morito
authors: M
authors: Monden
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006503:Hepatic Veins / Q000473:pathology; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D011169:Portal Vein / Q000473:pathology; D012074:Remission Induction; D013927:Thrombosis / Q000473:pathology; D014682:Vena Cava, Inferior / Q000473:pathology
chemical_list: D004317:Doxorubicin; D002945:Cisplatin; D005472:Fluorouracil