title: TMC-260, a new inhibitor of IL-4 signal transduction produced by Acremonium kiliense Grütz TC 1703.
authors: Discovery & Pharmacology Research Laboratories, Tanabe Seiyaku Co., Ltd., 2-50 Kawagishi-2-chome, Toda-shi, Saitama 335-8505, Japan. sakura@tanabe.co.jp
authors: Masaaki
authors: M
authors: Sakurai
authors: Hiroyuki
authors: H
authors: Hoshino
authors: Jun
authors: J
authors: Kohno
authors: Maki
authors: M
authors: Nishio
authors: Noboru
authors: N
authors: Kishi
authors: Toru
authors: T
authors: Okuda
authors: Kimio
authors: K
authors: Kawano
authors: Tetsuo
authors: T
authors: Ohnuki
mesh_terms: D000164:Acremonium / Q000254:growth & development / Q000378:metabolism*; D002460:Cell Line; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015847:Interleukin-4 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects*
chemical_list: D011760:Pyrrolidinones; C479707:TMC 260; D015847:Interleukin-4