title: [Intraoperative extracorporeal irradiation and replantation in local treatment of primary malignant bone tumors].
abstract: In 13 patients with primary malignant bone tumors (10 Ewing's sarcoma, 1 parosteal osteosarcoma, 1 adamantinoma recurrence, and 1 MFH) local therapy was performed as intraoperative extracorporeal irradiation and replantation (IEIR) of the involved bone segment (5 tibia, 2 femur, and 6 pelvis). Of the 13 patients (69%), 9 are alive at the time of the follow-up (5 CDF, 4 AWM(treated)) and 4 patients died of disease (DOD). Up to now during the follow-up of 32 months (6-57), no local recurrence was observed in the replanted bone segments. The complication rate was very high (18 complications in 11 of the 13 patients, including 6 cases with complication V degrees according to Ruggieri with loss of the reconstruction). The typical complication is severe local infection necessitating removal of the replant. In cases of mechanical failure, the replanted segment could mostly be preserved by surgical revision and autologous bone grafting. If serious complications can be managed or avoided, functional results can be achieved. IEIR must be seen as an extraordinary reconstruction procedure in cases where established procedures such as endoprosthesis, biological reconstructions, or rotationplasties cannot be used or are refused by the patient.
authors: Abteilung Orthopädie I, Orthopädische Universitätsklinik, Heidelberg. desiderius.sabo@ok.uni-heidelberg.de
authors: D
authors: D
authors: Sabo
authors: L
authors: L
authors: Bernd
authors: M
authors: M
authors: Buchner
authors: M
authors: M
authors: Treiber
authors: M
authors: M
authors: Wannenmacher
authors: V
authors: V
authors: Ewerbeck
authors: D
authors: D
authors: Parsch
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000564:Ameloblastoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D000671:Amputation, Surgical / Q000379:methods*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D001918:Brachytherapy / Q000379:methods*; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005266:Femoral Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D005500:Follow-Up Studies; D054747:Histiocytic Sarcoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D023821:Limb Salvage / Q000379:methods*; D008297:Male; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D009367:Neoplasm Staging; D012516:Osteosarcoma / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D011879:Radiotherapy Dosage; D012092:Replantation / Q000379:methods*; D012512:Sarcoma, Ewing / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D013977:Tibia / Q000473:pathology / Q000601:surgery