The annexin 1 receptor(s): is the plot unravelling?
Recent studies have proposed a functional link between annexin 1 (ANXA1), an endogenous anti-inflammatory mediator, and receptors of the formyl-peptide family. In particular, exogenous and endogenous ANXA1 and its peptidomimetics interact with one member of this family, the formyl-peptide-receptor-like 1. Further analyses of the interactions between ANXA1 and this and other members of this receptor family, and a better characterization of the ANXA1 receptor systems in models of inflammation, might clarify their mechanism of anti-inflammatory effects. This line of research will facilitate the development of ANXA1 mimetics and take advantage of >20 years of biological research into the functions of this glucocorticoid-modulated protein.
Perretti
Mauro
M
William Harvey Research Institute, Bart's and The London, Queen Mary School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK. M.Perretti@qmul.ac.uk
D000818:Animals; D017305:Annexin A1 / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D018836:Inflammation Mediators / Q000502:physiology; D008954:Models, Biological; D009504:Neutrophils / Q000378:metabolism; D044042:Receptors, Formyl Peptide / Q000378:metabolism; D018000:Receptors, Peptide / Q000378:metabolism*
D017305:Annexin A1; D018836:Inflammation Mediators; D044042:Receptors, Formyl Peptide; D018000:Receptors, Peptide