title: Development and physical characterization of sorbitan monoester niosomes for insulin oral delivery.
abstract: Niosomes of sorbitan monoesters (Span 20, 40, 60, and 80) were prepared using the film hydration method without sonication. Unlike the other surfactants, Span 80 did not form niosomes in the absence of a sufficient amount of cholesterol. The size of vesicles depended on the cholesterol molar ratio or charge incorporation. The amount of insulin released in simulated intestinal fluid from Span 40 and 60 was lower than Span 20 and 80 vesicles. Vesicles containing Span 60 showed the highest protection of insulin against proteolytic enzymes and good stability in the presence of sodium desoxycholate and storage temperatures.
authors: Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. J_varshosaz@hotmail.com
authors: Jaleh
authors: J
authors: Varshosaz
authors: Abbas
authors: A
authors: Pardakhty
authors: Val-Iollah
authors: VI
authors: Hajhashemi
authors: Abdolhossein Rouholamini
authors: AR
authors: Najafabadi
mesh_terms: D000284:Administration, Oral; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D011136:Polysorbates / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D004337:Drug Carriers; D007328:Insulin; D011136:Polysorbates; D013501:Surface-Active Agents