title: A polymeric mini-stent designed to facilitate the vasectomy reversal operation. A rabbit model study.
abstract: Vasectomy has become popular since it is the safest surgical method for contraception. It is known that approximately 6% of the men that undergo vasectomy will seek reversal (vasovasostomy). This operation is, however, technically demanding and relatively time-consuming. This study was based on the hypothesis that a polymeric mini-stent can facilitate and accelerate vasovasostomies. A mini-stent was manufactured out of a crosslinked hydrogel biomaterial, which was synthesized from N-vinyl-pyrrolidinone (NVP), n-butylmethacrylate, and (triethyleneglycol) dimethacrylate. The device was tested with 28 rabbits, which were divided over two equal groups. In one group, the vasa deferentia were dissected and reanastomosed via microsurgical one-layer technique (end-to-end group). In the other group, the vasa deferentia were dissected and reattached through implantation of the mini-stent. Sperm counts revealed 100% patency in both groups, i.e. all vasovasostomies were successful. It was experienced that the operation was easier and faster in the case of the mini-stent, probably since the mini-stent keeps the lumens of both vas ends exactly in line during suturing. This study demonstrates the feasibility of the mini-stent. Further work is necessary to evaluate the utility of this approach for clinical vasovasostomies.
authors: Department of Urology, Catharina Hospital, Eindhoven, The Netherlands.
authors: Eric J
authors: EJ
authors: Vrijhof
authors: Adriaan
authors: A
authors: de Bruïne
authors: August A B
authors: AA
authors: Lycklama à Nijeholt
authors: Leo H
authors: LH
authors: Koole
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D019544:Equipment Failure Analysis / Q000379:methods*; D006801:Humans; D007248:Infertility, Male / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D008866:Microsurgery / Q000295:instrumentation / Q000379:methods; D008904:Miniaturization; D011108:Polymers; D011474:Prosthesis Design; D011817:Rabbits; D020127:Recovery of Function; D013076:Sperm Count; D015607:Stents; D016896:Treatment Outcome; D014649:Vas Deferens / Q000473:pathology* / Q000601:surgery*; D014669:Vasovasostomy / Q000295:instrumentation* / Q000379:methods*
chemical_list: D011108:Polymers