Jenamidines A to C: unusual alkaloids from Streptomyces sp. with specific antiproliferative properties obtained by chemical screening.
Three new naturally occurring bicyclic alkaloids, jenamidines A (1), B (2) and C (3), were discovered and isolated from the culture broth of Streptomyces sp. (strain HKI0297) via the chemical screening approach. Fermentation, isolation, structure and biological activities of these three new secondary metabolites are reported. The jenamidines have an unusual octahydro-pyrido[1,2-a]pyrimidine skeleton. Jenamidine A (1) shows antiproliferative effects against the chronic myeloid leukaemic cell line K-562. In addition, the new tricyclic sesquiterpenoid, africantriol (4) was isolated from the same strain.
Hu
Jin-Feng
JF
Hans-Knöll-Institute for Natural Products Research, Beutenbergstrasse 11a, D-07745 Jena, Germany.
Wunderlich
Dirk
D
Thiericke
Ralf
R
Dahse
Hans-Martin
HM
Grabley
Susanne
S
Feng
Xiao-Zhang
XZ
Sattler
Isabel
I
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D011744:Pyrimidinones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D013302:Streptomyces / Q000254:growth & development / Q000378:metabolism*
D000470:Alkaloids; D000903:Antibiotics, Antineoplastic; D001952:Bridged-Ring Compounds; D011725:Pyridines; D011744:Pyrimidinones; D012717:Sesquiterpenes; C479699:africantriol; C479696:jenamidine A; C479697:jenamidine B; C479698:jenamidine C