Jaundice in low birthweight infants: pathobiology and outcome.
Jaundice in preterm, as well as full term, infants results from (a) an increased bilirubin load in the hepatocyte, (b) decreased hepatic uptake of bilirubin from the plasma, and/or (c) defective bilirubin conjugation. Hyperbilirubinaemia in preterm infants is more prevalent, more severe, and its course more protracted than in term neonates.
Watchko
J F
JF
Division of Neonatology and Developmental Biology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA. jwatchko@mail.magee.edu
Maisels
M J
MJ
D001663:Bilirubin / Q000378:metabolism; D006801:Humans; D006932:Hyperbilirubinemia / Q000150:complications / Q000378:metabolism / Q000628:therapy; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D007567:Jaundice, Neonatal / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D007647:Kernicterus / Q000209:etiology; D010789:Phototherapy / Q000379:methods; D011379:Prognosis; D012307:Risk Factors
D001663:Bilirubin