Disparity for a newly identified minor histocompatibility antigen, HA-8, correlates with acute graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling.
We recently identified a new minor histocompatibility antigen, termed HA-8, which is presented by human leucocyte antigen (HLA)-A*0201 or HLA-A*0202 and expressed ubiquitously among tissues. A retrospective analysis of 577 Caucasian patients with HLA-A*0201 or A*0202 who had received a haematopoietic stem cell transplant from a human leucocyte antigen (HLA)-identical sibling was conducted to determine whether HA-8 disparity correlated with clinical outcome. HA-8 disparity was detected in 72 recipients, and grades II-IV graft-versus-host disease (GVHD) occurred in 46 (64%), compared with 251 (50%) of the 503 patients without HA-8 disparity. After adjusting for known risk factors for acute GVHD, this difference was statistically significant (odds ratio, 1.8; 95% confidence interval, 1.0-3.1; P = 0.04). However, the hazards of clinical extensive chronic GVHD, overall mortality and recurrent malignancy were not statistically significantly different between the two groups. These data suggest that the increased risk of acute GVHD associated with recipient HA-8 disparity was not sufficient to change other clinical outcomes.
Akatsuka
Yoshiki
Y
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. yakatsuk@aichi-cc.jp
Warren
Edus H
EH
Gooley
Ted A
TA
Brickner
Anthony G
AG
Lin
Ming-Tseh
MT
Hansen
John A
JA
Martin
Paul J
PJ
Madtes
David K
DK
Engelhard
Victor H
VH
Takahashi
Toshitada
T
Riddell
Stanley R
SR
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology* / Q000401:mortality; D015789:HLA-A2 Antigen / Q000032:analysis; D018380:Hematopoietic Stem Cell Transplantation / Q000401:mortality; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015778:Minor Histocompatibility Antigens / Q000235:genetics / Q000276:immunology*; D011110:Polymorphism, Genetic; D011336:Probability; D015996:Survival Rate; D014181:Transplantation Immunology; D014185:Transplantation, Isogeneic
D015789:HLA-A2 Antigen; D015778:Minor Histocompatibility Antigens; C479948:PUM3 protein, human