An accurately-constructed structural model for an active site of Fe-containing superoxide dismutases (Fe-SODs).
A novel structural model, [Fe(bpga)(N(3))(OCH(3))] (1) (BPGA: bis(6-pivalamido-2-pyridylmethyl)(carboxy-methyl)amine), for an active site of Fe-containing SOD enzyme with N(3)(-) has been accurately designed and prepared, which has been characterized by X-ray structure analysis and UV-vis, ESR, and IR spectroscopies. Reaction of 1 with acid/base in methanol has shown that the superoxide-accessible site is the N(3)(-)-coordination site in the equatorial plane.
Yamaguchi
Syuhei
S
Department of Applied Chemistry, Nagoya Institute of Technology, Showa-ku, Nagoya 466-8555, Japan.
Kumagai
Akinori
A
Funahashi
Yasuhiro
Y
Jitsukawa
Koichiro
K
Masuda
Hideki
H
D001665:Binding Sites; D018360:Crystallography, X-Ray; D005290:Ferric Compounds / Q000737:chemistry*; D008024:Ligands; D008956:Models, Chemical; D010084:Oxidation-Reduction; D013056:Spectrophotometry, Ultraviolet; D013482:Superoxide Dismutase / Q000737:chemistry*
D005290:Ferric Compounds; D008024:Ligands; D013482:Superoxide Dismutase