Infliximab treatment of Crohn disease ileovesical fistula.
Ileovesical fistula is a rare inaugural complication of Crohn disease. Current approaches associate antibiotics, total parenteral nutrition and various combinations of immunomodulatory agents. However, only a minority of fistulas subside under conventional treatment, as most of them ultimately require complex surgery to excise and close the structures involved. We report the case of a 31-year-old patient successfully treated by targeting the local production of tumour necrosis factor alpha with infliximab.
Gamé
X
X
Dept. of Urology, University Hospital Rangueil, Toulouse, France. xaviergame@hotmail.com
Malavaud
B
B
Alric
L
L
Mouzin
M
M
Sarramon
J P
JP
Rischmann
P
P
D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003424:Crohn Disease / Q000150:complications*; D006801:Humans; D007077:Ileal Diseases / Q000188:drug therapy* / Q000209:etiology; D000069285:Infliximab; D007412:Intestinal Fistula / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D001747:Urinary Bladder Fistula / Q000188:drug therapy* / Q000209:etiology
D000911:Antibodies, Monoclonal; D000069285:Infliximab