Unexplained visual loss.
Dominant optic atrophy is the most common heredodegenerative optic neuropathy. Typically, patients present with slowly progressive, bilaterally decreased central visual acuity. Subtle central or cecocentral visual field defect and normal peripheral isopters are demonstrated with perimetry. A defect in blue-yellow discrimination (tritan error axis) is the most common type of dyschromatopsia, however protan and deutan axes may be superimposed. A characteristic optic disk appearance includes temporal disk pallor with excavation. An autosomal dominant inheritance pattern can often be elicited from the family history.
Buono
Lawrence M
LM
Neuro-Ophthalmology Service, Wills Eye Hospital/Thomas Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA.
Foroozan
Rod
R
Sergott
Robert C
RC
D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D029241:Optic Atrophy, Autosomal Dominant / Q000150:complications / Q000175:diagnosis*; D014786:Vision Disorders / Q000175:diagnosis* / Q000209:etiology; D014792:Visual Acuity; D014794:Visual Fields