[Comparative analysis of disorders in duodenal lymphoid tissue of mice treated with azathioprine and herbicide 2,4-dichlorophenoxyacetic acid and their correction by plant and animal origin remedies].
Comparative study of disturbances of intramural duodenal lymphoid tissue in mice, which were induced by the action of "classical" immunosuppressing drug azathioprine and by herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) showed similar immunosuppressing effect that was more potent after herbicide treatment. Significant reduction in the number of the cells of lymphoid series found in the duodenal wall was accompanied by inflammatory-destructive processes and adipose tissue outgrowth. Administration of hypolipidemic plant extract to animals immunosuppressed with either azathioprine or herbicide 2,4-D, promoted the restoration of intramural duodenal morphological structures and the restitution of lymphoid cell parameters in lamina propria practically to the level of control values. The results obtained indicate the immuno-correcting effect of the plant extract, which is determined by a rich complex of biologically active substances of its components. Active thymic fraction (AFT-2) was also found to possess an immuno-correcting effect, promoting the restoration of cellular composition of diffuse lymphoid tissue in duodenal lamina propria. Immuno-correcting effect of AFT-2 seems to result from the activity of its component thymic peptides.
Sapin
M R
MR
Problem Scientific Research Laboratory of Immunochemistry, East-Siberian State Technological University, Ulan-Ude.
Lebedeva
S N
SN
Zhamsaranova
S D
SD
Erofeeva
L M
LM
D015084:2,4-Dichlorophenoxyacetic Acid / Q000633:toxicity; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001379:Azathioprine / Q000633:toxicity; D002417:Cattle; D002452:Cell Count; D004386:Duodenum / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D006540:Herbicides / Q000633:toxicity; D007166:Immunosuppressive Agents / Q000633:toxicity*; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D013950:Thymus Gland / Q000737:chemistry
D000276:Adjuvants, Immunologic; D006540:Herbicides; D007166:Immunosuppressive Agents; D010455:Peptides; D010936:Plant Extracts; D015084:2,4-Dichlorophenoxyacetic Acid; D001379:Azathioprine