[Effect of different tension stress on the proliferation activity of human periodontal ligament fibroblast in vitro].
OBJECTIVE
The aim of this study was examine the proliferation activity of human periodontal ligament fibroblasts (HPDLF) under different tension stress in vitro so as to learn the stress-biological effect and growth regularity in orthodontic treatment of HPDLF.


METHODS
HPDLF were harvested and subjected to the cellular mechanical research system, and the levels of proliferation activity under static and dynamic tension stress in different frequency and magnitude were detected by use of 3H-TdR at 16 h, 24 h and 32 h.


RESULTS
It was found that the proliferation activity of HPDLF obviously increased in the static tension stress group (5 kPa), whereas the proliferation activity of HPDLF appeared to decrease in the dynamic tension stress groups (5 kPa-2.5 kPa-5 kPa; 5 kPa-0-5 kPa).


CONCLUSIONS
Different tension stress patterns have different effects on the proliferation of HPDLF. Static tension stress can obviously enhance the proliferation of HPDLF.
Zhou
Jixiang
J
Department of Orthodontics, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Zhao
Zhihe
Z
Tan
Lijun
L
Lin
Zhu
Z
D002455:Cell Division; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology*; D006801:Humans; D010513:Periodontal Ligament / Q000166:cytology*; D013718:Tensile Strength