title: Botulinum toxin for the treatment of secondary chronic anal fissure.
abstract: BACKGROUND
  Botulinum toxin A (BT-A) injection into internal or external anal sphincter causes relaxation of the anal sphincters, enhancing microcirculation at the fissure site and promoting fissure healing. There are no such observations in patients with secondary anal fissure.
  
  
  METHODS
  Six patients with fissures after surgical or nonsurgical treatment of hemorrhoids and four patients with ulcerative colitis received injections of BT-A on both edges of the fissure (total dose, 25 U Botox).
  
  
  RESULTS
  In the week following BTA injection, patients with fissure after hemorrhoids treatment had relief of fissure symptoms, but one month later the fissures still existed. They then received an additional 25 U Botox. One month after the second BT-A injection, all fissures were healed. The patients with ulcerative colitis had only symptomatic improvement after BT-A injection.
  
  
  CONCLUSIONS
  BT-A therapy seems effective for the treatment of chronic anal fissure after surgical or nonsurgical treatment of hemorrhoids.
authors: Second Department of Internal Medicine, St. Wojciech-Adalbertus Hospital, Gdańsk, Poland. m.h.madalinski@pro.onet.pl
authors: M H
authors: MH
authors: Madaliński
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000150:complications / Q000601:surgery; D005260:Female; D005401:Fissure in Ano / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D005500:Follow-Up Studies; D006484:Hemorrhoids / Q000150:complications / Q000601:surgery; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D018570:Risk Assessment; D012494:Sampling Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology
chemical_list: D019274:Botulinum Toxins, Type A