Enantioresolution of fluorinated diphenylmethanols and determination of their absolute configurations by X-Ray crystallographic and 1H NMR anisotropy methods.
Various fluorinated diphenylmethanols were enantioresolved by the methods of chiral camphorsultam-dichlorophthalic acid (CSDP acid) and/or 2-methoxy-2-(1-naphthyl)propionic acid (MalphaNP acid) yielding enantiopure alcohols. Their absolute configurations were unambiguously determined by X-ray crystallography of CSDP esters and/or by the (1)H NMR anisotropy method of MalphaNP esters for the first time.
Naito
Junpei
J
Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Sendai, Japan.
Kosaka
Masashi
M
Sugito
Takeo
T
Watanabe
Masataka
M
Harada
Nobuyuki
N
Pirkle
William H
WH