title: Seroprevalence of neutralizing antibodies to measles virus in a vaccinated population in Iran, 1998.
abstract: Measles is an acute highly infectious viral disease. Although live attenuated vaccine is used throughout the world, outbreaks of disease still occur in many countries including Iran. In this cross-sectional study, by implementing a viral neutralization test and cell culture techniques, the seroprevalence of neutralizing anti-measles antibodies was assessed. Three hundred and fifty-four blood samples were collected and random-cluster classified from healthy subjects 6 months to 16 years old, residing in the town of Khodabandeh and its rural areas. Of the total subjects, 174 (49.2%) were girls and 180 (50.8%) were boys. From 354 subjects studied, 310 (87.6%) had neutralizing anti-measles antibody titer of 1:8 or higher and were considered to be immune and 44 (12.4%) had lower antibody titers. At the time of specimen collection, information with regards to age, sex, history of vaccination and place of residence were collected. Chi2 statistical test demonstrated a significant association between immune status and grouped age at the time of first vaccination (p < 0.009). The proportion test indicated significant differences in rate of seropositivity in paired age groups (3-8 vs. 9-11 and 9-11 vs. 12-64 months) (p < 0.02). The use of reliable techniques for assessing success of vaccination programs and performing seroepidemiological studies in order to organize national programs of control and eradication of measles are necessary.
authors: Department of Virology, Faculty of Medical Sciences, Tarbiat Modarres University, Tehran, Iran.
authors: Mazaher Khodabandeh
authors: MK
authors: Loo
authors: Farzaneh
authors: F
authors: Sabahi
authors: Horieh
authors: H
authors: Soleimanjdahi
authors: Anooshirvan
authors: A
authors: Kazemnejad
authors: Mohammod Hassan
authors: MH
authors: Roustai
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D017589:Immunization Programs; D007115:Immunization Schedule; D007223:Infant; D007492:Iran / Q000453:epidemiology; D008297:Male; D008457:Measles / Q000097:blood / Q000453:epidemiology* / Q000276:immunology* / Q000517:prevention & control; D008458:Measles Vaccine / Q000276:immunology* / Q000627:therapeutic use; D008459:Measles virus / Q000276:immunology*; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral; D008458:Measles Vaccine