Quantitative MRI comparison of systemic hemodynamics in Mustard/Senning repaired patients and healthy volunteers at rest.
The purpose of the present study was to non-invasively compare ascending aortic blood flow and cross-sectional area (CSA) variations vs time in Mustard or Senning repaired (MSR) patients against those of healthy volunteers at rest. Velocity-encoded MR imaging was performed in 10 male patients (age range 18-24 years, median age 20.5 years) late after a Mustard or Senning correction, and in 10 male healthy volunteers (age range 21-25 years, median age 22.5 years), at the upper part of the ascending aorta. Both aortic cross-sectional area (CSA) and blood-flow variations were recorded over a complete cardiac cycle, with a 30-ms time of resolution. The body-surface area (BSA), the mean CSA over the systolic phase, and the BSA-normalized systemic ventricle power and work were significantly lower in the patient series compared with those of the volunteer series. The BSA-normalized right ventricle (RV) power and work of MSR patients were equal to 87 and 83% on average of those of the left ventricle (LV) of healthy volunteers. We conclude that, at rest, the mechanical performance of the systemic RV in MSR patients is significantly lower than that of the LV in healthy volunteers. Furthermore, the significantly lower aortic CSA found in MSR patients than in healthy volunteers may reveal an increase in the vasomotor tone.
Laffon
Eric
E
Service de Médecine Nucléaire, Hôpital du Haut-Lévêque, 33604 Pessac, France. elaffon@u-bordeaux2.fr
Jimenez
Maria
M
Latrabe
Valérie
V
Ducassou
Dominique
D
Choussat
Alain
A
Marthan
Roger
R
Laurent
François
F
D000293:Adolescent; D000328:Adult; D001011:Aorta / Q000502:physiology / Q000503:physiopathology*; D001783:Blood Flow Velocity / Q000502:physiology; D001830:Body Surface Area; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D011184:Postoperative Period; D012016:Reference Values; D018709:Statistics, Nonparametric; D013318:Stroke Volume / Q000502:physiology; D013997:Time Factors; D014188:Transposition of Great Vessels / Q000503:physiopathology* / Q000601:surgery; D016276:Ventricular Function / Q000502:physiology