The impact of ischemic lesions in the donor kidney, donor age, recipient age and HLA (A, B, C, DR, DQ) matching on clinical course after kidney grafting.
It is generally accepted that HLA matching improves graft survival. However, there is no consensus on whether this improvement is reflected on daily clinical course. Clinical course after renal transplantation depends on many factors, such as donor age, recipient age, ischemic score in the kidney, and HLA matching. The relative contribution of these factors is unknown. Because management of the recipients in the various centers differs considerably, only a single centre study would reveal the relative contribution of all these factors. Therefore, in our centre we studied the influence of these parameters on the clinical course after renal allografting.
Christiaans
M H
MH
Department of Internal Medicine, University Hospital Maastricht, Maastricht, The Netherlands.
Peltenburg
H G
HG
Niemann
F H
FH
Kootstra
G
G
Lavrijssen
A T
AT
van den Berg-Loonen
P M
PM
Tiebosch
A
A
Leunissen
K M
KM
van Hooff
J P
JP
D000367:Age Factors; D000704:Analysis of Variance; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology* / Q000276:immunology; D006085:Graft Survival / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D015234:HLA-A Antigens / Q000276:immunology; D015235:HLA-B Antigens / Q000276:immunology; D015236:HLA-C Antigens / Q000276:immunology; D006683:HLA-DQ Antigens / Q000276:immunology; D006684:HLA-DR Antigens / Q000276:immunology; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D007511:Ischemia / Q000276:immunology*; D007668:Kidney / Q000098:blood supply* / Q000276:immunology*; D008875:Middle Aged; D012044:Regression Analysis; D014019:Tissue Donors / Q000706:statistics & numerical data*; D016896:Treatment Outcome
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens