title: Markers of bone metabolism in dog breeds of different size.
abstract: Serum and urinary markers of bone turnover may be of value in animals as noninvasive tools for determining the response of the skeleton to disease and injury. Although normal values for bone markers have been reported for the Beagle, concerns remain that breed to breed differences will complicate the interpretation of bone marker data in dogs. To explore this, we examined serum bone markers in two breeds of vastly different size, Pomeranians and Irish Wolfhounds. Our hypothesis was that serum concentrations of bone markers are similar in toy and giant dog breeds and fall within the same range as those reported for Beagles. Bone alkaline phosphatase (BALP) and carboxy-terminal telopeptide of type I collagen (ICTP), respectively markers of bone formation and bone resorption, were measured in age matched Pomeranians (n=14) and Irish Wolfhounds (n=14). No statistically significant differences between the mean BALP and mean ICTP serum concentrations from Pomeranians and Irish Wolfhounds were found. All BALP and ICTP concentrations were within the reference range reported for Beagles. The results of this study suggest that serum BALP and ICTP concentrations in giant and toy breeds are the same as in Beagles and that these assays may be used for dogs of all sizes.
authors.affiliation: Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN 47907, USA. breur@purdue.edu
authors.forename: Gert J
authors.initials: GJ
authors.lastname: Breur
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Allen
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Carlson
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Richardson
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001824:Body Constitution; D001842:Bone and Bones / Q000378:metabolism*; D024042:Collagen Type I; D004285:Dogs / Q000033:anatomy & histology* / Q000378:metabolism*; D010446:Peptide Fragments / Q000097:blood; D010455:Peptides; D011347:Procollagen / Q000097:blood; D013045:Species Specificity
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; D000469:Alkaline Phosphatase