title: Acute myocardial infarction in sickle cell anemia.
abstract: Cardiovascular dysfunction consistent with ischemia has been observed during episodes of painful crisis and following periods of heavy physical exertion in individuals with sickle cell disease. Similar findings have been observed in other individuals while taking the alpha-adrenergic agonist pseudoephedrine. However, acute myocardial infarction is extremely rare. The authors describe a case of sudden death in a child with sickle cell disease due to acute myocardial infarction and suggest that heavy exertional stress and use of pseudoephedrine may have precipitated the event.
authors.affiliation: Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas, 75390-9063, USA. Chatchawin.Assanasen@UTSouthwestern.edu
authors.forename: Chatchawin
authors.initials: C
authors.lastname: Assanasen
authors.forename: Reade A
authors.initials: RA
authors.lastname: Quinton
authors.forename: George R
authors.initials: GR
authors.lastname: Buchanan
mesh_terms: D000293:Adolescent; D000316:Adrenergic alpha-Agonists / Q000009:adverse effects; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000473:pathology; D001344:Autopsy; D017809:Fatal Outcome; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology*; D005082:Physical Exertion; D012307:Risk Factors
chemical_list: D000316:Adrenergic alpha-Agonists