title: [A multicentric variant of renal carcinoma growth].
abstract: 78 kidneys removed for cancer in 1999-2002 were studied for multifocal growth of the tumor. The results demonstrated a direct correlation between multicenter growth of renal cell carcinoma (RCC), size of the primary tumor and stage of the disease. Most of the additional foci were detected at the distance of more than 2.0 cm from the primary tumor, i.e. outside the safety zones in conduction of organ-saving operations. Frequent coincidence of a morphological type of the primary and additional tumors (70%), degree of cell differentiation (80%) and higher incidence of multifocality in infiltrative growth of the primary tumor support the existing hypophysis about the role of intra-organ metastasizing as the underlying cause of multifocal lesions. Also, the study confirmed low preoperative detection of multifocality: 1.8% preoperatively and 19.2% under investigation.
authors.forename: O B
authors.initials: OB
authors.lastname: Loran
authors.forename: A V
authors.initials: AV
authors.lastname: Seregin
authors.forename: S E
authors.initials: SE
authors.lastname: Tsyganov
mesh_terms: D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D002454:Cell Differentiation; D014644:Genetic Variation; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000601:surgery; D009392:Nephrectomy; D012189:Retrospective Studies