Pasteurized tumoral autograft and adjuvant chemotherapy for the treatment of canine distal radial osteosarcoma: 13 cases.
OBJECTIVE
To report outcome in 13 dogs with distal radial osteosarcoma, without evidence of metastasis, treated by a combination of adjuvant chemotherapy and a pasteurized autograft limb-sparing procedure.


METHODS
Prospective clinical study.


METHODS
Thirteen dogs with distal radial osteosarcoma.


METHODS
Limb-sparing procedure was performed using an autograft from the excised tumoral segment, pasteurized at 65 degrees C for 40 minutes. Adjuvant chemotherapy (cisplatin or cisplatin and doxorubicin) was administered in all dogs.


RESULTS
Mean and median survival times were 531 and 324 days, respectively (range, 180 to 1,868 days). Overall survival was 100% at 6 months, 50% at 12 months, 44% at 18 months, and 22% at 24 months. Lung metastasis occurred in 5 (38%) dogs. Observed complications were local recurrence (2 dogs, 15%), allograft infection (4 dogs, 31%), and implant failure (3 dogs, 23%). Limb function was good in 12 dogs (92%) and fair in 1 dog.


CONCLUSIONS
Pasteurized bone autograft derived from the tumoral bone segment was an effective alternative to cortical bone allograft for limb sparing in canine distal radial osteosarcoma, in terms of feasibility, pattern of healing, complications, and survival.


CONCLUSIONS
Use of a pasteurized bone autograft eliminates the need for a canine bone allograft bank and has the added advantage of good fit to the recipient site.
Morello
Emanuela
E
Dipartimento di Patologia Animale, School of Veterinary Medicine, Turin, Italy.
Vasconi
Elisabetta
E
Martano
Marina
M
Peirone
Bruno
B
Buracco
Paolo
P
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery / Q000662:veterinary*; D016025:Bone Transplantation / Q000379:methods / Q000662:veterinary*; D017024:Chemotherapy, Adjuvant / Q000662:veterinary; D002945:Cisplatin / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D004285:Dogs; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000662:veterinary; D012516:Osteosarcoma / Q000188:drug therapy / Q000401:mortality / Q000601:surgery / Q000662:veterinary*; D011183:Postoperative Complications / Q000662:veterinary; D011446:Prospective Studies; D011884:Radius / Q000473:pathology; D016019:Survival Analysis; D014182:Transplantation, Autologous / Q000662:veterinary; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D004317:Doxorubicin; D002945:Cisplatin