Rosai-Dorfman disease of the pleura: a rare extranodal presentation.
We present a case of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) manifesting primarily as a pleural disease without involvement of the lung parenchyma. The patient is an 81-year-old man who presented with increasing shortness of breath. Radiographic studies revealed a large loculated left-sided pleural effusion and parietal pleural thickening. Video-assisted thoracoscopic biopsy of the pleura showed the characteristic S100-positive histiocytes exhibiting emperipolesis. In this rare case of pleural Rosai-Dorfman disease, the extensive involvement of the pleural lymphatics by the characteristic histiocytes appears to have been responsible for the pleural effusion.
Ohori
N Paul
NP
Department of Pathology, University of Pittsburgh School of Medicine and UPMC-Presbyterian, PA 15213, USA.
Yu
Jing
J
Landreneau
Rodney J
RJ
Thaete
F Leland
FL
Kane
Kevin
K
D000368:Aged; D000369:Aged, 80 and over; D006644:Histiocytes / Q000378:metabolism / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D010995:Pleural Diseases / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D010996:Pleural Effusion / Q000209:etiology; D009418:S100 Proteins / Q000378:metabolism
D009418:S100 Proteins