title: [Integration of modern technologies in therapy of sarcomas of the pelvis. Computer-assisted hemipelvectomy and implantation of a "custom-made" Bonit gentamycin coated partial pelvic prosthesis].
abstract: The resection of primary malignancies in the pelvis is technically demanding as organs and structures are to be preserved and reconstruction of the defect as well as the postoperative function and rehabilitation are dependent on an optimal prosthesis. We present two patients with a sarcoma of the pelvis where for the first time a structured concept of technology integration led to a press-fit implantation of a hemipelvic prosthesis. This concept includes the design and production of a "custom-made" prosthesis as a hemipelvic substitute and the coating of this prosthesis with Bonit, a second-generation calcium phosphate, and gentamycin in watery solution. The tumor resection was done with computer-assisted surgery based on computed tomographies (CT) of the pelvis model done by rapid prototyping rather than on the CT of the patients' pelvis. With this procedure the presurgically simulated resection could be executed precisely with complete resection of the tumors and an accuracy which allowed an exact implantation of the prosthesis. The course was uneventful with primary healing and no sign of an infection or loosening after 6 months.
authors.affiliation: Unfallchirurgische Klinik, Medizinische Hochschule, Hannover. Bastian.Leonard@mh-hannover.de
authors.forename: L
authors.initials: L
authors.lastname: Bastian
authors.forename: T
authors.initials: T
authors.lastname: Hüfner
authors.forename: E
authors.initials: E
authors.lastname: Mössinger
authors.forename: J
authors.initials: J
authors.lastname: Geerling
authors.forename: T
authors.initials: T
authors.lastname: Goesling
authors.forename: M
authors.initials: M
authors.lastname: Busche
authors.forename: D
authors.initials: D
authors.lastname: Kendoff
authors.forename: S
authors.initials: S
authors.lastname: Bading
authors.forename: H
authors.initials: H
authors.lastname: Rosenthal
authors.forename: C
authors.initials: C
authors.lastname: Krettek
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D001860:Bone Plates; D001863:Bone Screws; D002130:Calcium Phosphates; D002813:Chondrosarcoma / Q000000981:diagnostic imaging / Q000601:surgery*; D020099:Coated Materials, Biocompatible; D003198:Computer Simulation; D017076:Computer-Aided Design / Q000295:instrumentation*; D005839:Gentamicins; D006428:Hemipelvectomy / Q000295:instrumentation*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D021621:Imaging, Three-Dimensional / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D010384:Pelvic Bones / Q000000981:diagnostic imaging / Q000601:surgery*; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000601:surgery; D011474:Prosthesis Design / Q000295:instrumentation; D019919:Prosthesis Implantation / Q000295:instrumentation*; D012086:Reoperation / Q000295:instrumentation; D015203:Reproducibility of Results; D012512:Sarcoma, Ewing / Q000000981:diagnostic imaging / Q000601:surgery*; D025321:Surgery, Computer-Assisted / Q000295:instrumentation*; D013673:Technology Assessment, Biomedical / Q000706:statistics & numerical data; D036542:Tomography, Spiral Computed / Q000295:instrumentation*
chemical_list: D002130:Calcium Phosphates; D020099:Coated Materials, Biocompatible; D005839:Gentamicins