Promoter polymorphisms of the CD14 gene are not associated with bronchial asthma in Caucasian children.
Several studies have investigated the association of a promoter polymorphism in CD14 with atopic phenotypes. We screened this and another polymorphism in 182 asthmatic children and found no association with asthma. Furthermore, there was substantial linkage disequilibrium of the polymorphisms. Thus CD14 does not play a major role in the development of asthma in our population of Caucasian children.
Heinzmann
A
A
University of Freiburg, Freiburg, Germnay. heinzemann@kikli.ukl.uni-freiburg.de
Dietrich
H
H
Jerkic
S-P
SP
Kurz
T
T
Deichmann
K A
KA
D000293:Adolescent; D001249:Asthma / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D005858:Germany; D006801:Humans; D015810:Linkage Disequilibrium; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic
D018950:Lipopolysaccharide Receptors