Cell-cycle control during meiotic maturation.
The meiotic cell cycle, which is comprised of two consecutive M-phases, is crucial for the production of haploid germ cells. Although both mitotic and meiotic M-phases share cyclin-B-Cdc2/CDK1 as a key controller, there are meiosis-specific modulations in the regulation of cyclin-B-Cdc2. Recent insights indicate that a common pattern in these modulations can be found by considering the particular activities of mitogen-activated protein kinase (MAPK) during meiosis. The G(2)-phase arrest of meiosis I is released via specific, MAPK-independent signalling that leads to cyclin-B-Cdc2 activation; thereafter, however, the meiotic process is under the control of interplay between MAPK and cyclin-B-Cdc2.
Kishimoto
Takeo
T
Laboratory of Cell and Developmental Biology, Graduate School of Bioscience, Tokyo Institute of Technology, Nagatsuta 4259, Midoriku, Yokohama 226-8501, Japan. tkishimo@bio.titech.ac.jp
D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism; D002453:Cell Cycle; D019926:Cyclin B / Q000378:metabolism; D005854:Germ Cells; D006801:Humans; D020935:MAP Kinase Signaling System; D008540:Meiosis; D008954:Models, Biological; D015398:Signal Transduction; D014981:Xenopus / Q000502:physiology*
D019926:Cyclin B; D016203:CDC2 Protein Kinase