Gender differences in the levels of bisphenol A metabolites in urine.
The metabolism of bisphenol A (BPA), a suspected endocrine disruptor, should be considered for monitoring human exposure to BPA, because the conjugation with beta-D-glucuronide and sulfate reduces the estrogenic activity. In this study, BPA levels in 30 healthy Koreans (men, N=15, 42.6+/-2.4 years; women, N=15, 43.0+/-2.7 years) were analyzed from urine treated with/without beta-glucuronidase and/or sulfatase by an RP-HPLC with fluorescence detection. The total BPA concentrations including free BPA and the urinary conjugates were similar in men and women (2.82+/-0.73 and 2.76+/-0.54 ng ml(-1), respectively), but gender differences were found in the levels of urinary BPA conjugates. Men had significantly higher levels of BPA-glucuronide (2.34+/-0.85 ng ml(-1)) than women (1.00+/-0.34 ng ml(-1)), whereas women had higher levels of BPA-sulfate (1.20+/-0.32 ng ml(-1)) than men (0.49+/-0.27 ng ml(-1)).
Kim
Yong-Hak
YH
Department of Preventive Medicine, School of Medicine, Seoul-National University, 28 Yon-gun Dong, Chong-no Gu, Seoul 110-799, Republic of Korea.
Kim
Cheong-Sik
CS
Park
Soyeon
S
Han
Soon Young
SY
Pyo
Myoung-Yun
MY
Yang
Mihi
M
D000328:Adult; D001559:Benzhydryl Compounds; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004785:Environmental Pollutants / Q000652:urine*; D005260:Female; D005966:Glucuronidase / Q000737:chemistry*; D006801:Humans; D008297:Male; D010636:Phenols / Q000737:chemistry* / Q000378:metabolism / Q000652:urine*; D011485:Protein Binding; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods; D013429:Sulfatases / Q000737:chemistry*; D016482:Urinalysis / Q000379:methods*; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D005966:Glucuronidase; D010636:Phenols; D013429:Sulfatases; C006780:bisphenol A; D000098826:Bisphenol A Compounds