Sunpollenol and five other rearranged 3,4-seco-tirucallane-type triterpenoids from sunflower pollen and their inhibitory effects on Epstein-Barr virus activation.
Six new rearranged 3,4-seco-tirucallane-type triterpenoids (1-6) have been isolated from the diethyl ether extract of the pollen grains of sunflower (Helianthus annuus). These compounds were evaluated with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. All of the compounds tested showed potent inhibitory effects on EBV-EA activation (97-100% inhibition at 1 x 10(3) mol ratio/TPA).
Ukiya
Motohiko
M
College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan.
Akihisa
Toshihiro
T
Tokuda
Harukuni
H
Koike
Kazuo
K
Kimura
Yumiko
Y
Asano
Takeshi
T
Motohashi
Shigeyasu
S
Nikaido
Tamotsu
T
Nishino
Hoyoku
H
D000956:Antigens, Viral / Q000187:drug effects; D006368:Helianthus / Q000737:chemistry*; D006801:Humans; D007564:Japan; D016393:Lymphoma, B-Cell; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D011058:Pollen / Q000737:chemistry*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014775:Virus Activation
D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D014315:Triterpenes; C482482:sunpollenol; D013755:Tetradecanoylphorbol Acetate