title: Qualitative evaluation of thermal desorption-programmable temperature vaporization-comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry for the analysis of selected halogenated contaminants.
abstract: The separation of 38 toxic and predominant polychlorinated biphenyl (PCB) congeners, 11 persistent halogenated pesticides, 1 brominated biphenyl (BB), and 8 polybrominated diphenyl ethers (PBDEs) has been optimized using comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (GC x GC-TOFMS). A thermal desorption-programmable temperature vaporization (TD-PTV) step was used for the injection. Different column sets were investigated, and a 100% dimethylpolysiloxane (15 m x 0.25 mm i.d. x 0.25 microm film thickness) narrowbore capillary column coupled to a high temperature (8% phenyl)-polycarborane-siloxane (2 m x 0.10 mm i.d. x 0.10 microm film thickness) microbore column set was selected. Of the 58 compounds investigated, only one pair of PCBs was not resolved. All other analytes were either baseline separated into the chromatographic plane or were virtually separated using the deconvolution capability of the TOFMS.
authors.affiliation: Centers for Disease Control and Prevention, National Centerfor Environmental Health, Division of Laboratory Sciences, Organic Analytical Toxicology Branch, 4770 Buford Hwy NE, Mail Stop F-17, Atlanta, GA 30341, USA. jfocant@cdc.gov
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Focant
authors.forename: Andreas
authors.initials: A
authors.lastname: Sjödin
authors.forename: Donald G
authors.initials: DG
authors.lastname: Patterson
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006219:Halogens / Q000032:analysis*; D012680:Sensitivity and Specificity
chemical_list: D006219:Halogens