Treatment of squamous cell carcinoma with intralesional 5-Fluorouracil.
BACKGROUND
5-Fluorouracil (5-FU) has been used topically and intralesionally to treat lesions related to squamous cell carcinoma (SCC) such as actinic keratosis, Bowen's disease, and keratoacanthoma.


OBJECTIVE
We sought to determine whether intralesional 5-FU might be effective in treating a patient with SCC.


METHODS
A patient with SCC at the junction of the right alar crease and right nasolabial fold was treated with eight weekly injections of 5-FU, with doses ranging from 0.8 to 2.4 mL.


RESULTS
A repeat biopsy after the eighth treatment showed total clearance of the cancer, and the patient has remained free of recurrence during a 5-month follow-up period.


CONCLUSIONS
This modality may provide patients with SCC in cosmetically important locations or in areas that require complex surgery the advantage of a nonsurgical cure.
Morse
Lisa G
LG
Department of Dermatology, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, New Orleans, LA 70112, USA.
Kendrick
Christina
C
Hooper
Deirdre
D
Ward
Holly
H
Parry
Edward
E
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D005145:Face; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D008875:Middle Aged; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil