title: Intravesical bacillus Calmette-Guèrin for the treatment of superficial bladder cancer in renal transplant patients.
abstract: BACKGROUND
  Intravesical instillations with bacillus Calmette-Guérin (BCG) is considered the treatment of choice in the prophylaxis of high-grade superficial bladder carcinoma and in the treatment of carcinoma in situ (CIS) of the bladder.
  
  
  METHODS
  There is no previous experience with BCG treatment in patients with renal transplantation. Theoretically, immunosuppression is a contraindication because of the risk of severe morbidity and sepsis. We present our experience with endovesical BCG in three renal transplant patients, under immunosuppressive treatment, with high-grade superficial bladder cancer and CIS.
  
  
  RESULTS
  Two patients are free of disease at 17 and 60 months. One patient developed disease recurrence and underwent a radical cystectomy. There was neither change in renal function nor any clinical evidence of tuberculous infection.
  
  
  CONCLUSIONS
  Intravesical BCG in superficial bladder cancer and/or CIS is a valid option, with no added morbidity to renal transplant patients.
authors.affiliation: Urology Department, Fundació Puigvert, Universidad Autónoma de Barcelona, Barcelona, Spain. jpalou@fundacio-puigvert.es
authors.forename: Juan
authors.initials: J
authors.lastname: Palou
authors.forename: Oriol
authors.initials: O
authors.lastname: Angerri
authors.forename: José
authors.initials: J
authors.lastname: Segarra
authors.forename: Juan
authors.initials: J
authors.lastname: Caparrós
authors.forename: Luis
authors.initials: L
authors.lastname: Guirado
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Diaz
authors.forename: José
authors.initials: J
authors.lastname: Salvador-Bayarri
authors.forename: Humberto
authors.initials: H
authors.lastname: Villavicencio-Mavrich
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D001500:BCG Vaccine / Q000008:administration & dosage / Q000627:therapeutic use*; D002278:Carcinoma in Situ / Q000188:drug therapy / Q000601:surgery; D018572:Disease-Free Survival; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy; D012008:Recurrence; D013997:Time Factors; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000601:surgery
chemical_list: D001500:BCG Vaccine