Conicamin, a novel histamine antagonist from the mediterranean tunicate Aplidium conicum.
In addition to the known 6-bromo-hypaphorine (2) and plakohypaphorine-A (3), the methanol extract of the Mediterranean tunicate Aplidium conicum was shown to contain conicamin, a novel indole alkaloid having histamine-antagonistic activity which structure was determined to be 1 on the basis of the spectral data.
Aiello
Anna
A
Dipartimento di Chimica delle Sostanze Naturali, via D. Montesano, 49, I-80131 Napoli, Italy.
Borrelli
Francesca
F
Capasso
Raffaele
R
Fattorusso
Ernesto
E
Luciano
Paolo
P
Menna
Marialuisa
M
D000818:Animals; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008968:Molecular Conformation; D015394:Molecular Structure; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D014561:Urochordata / Q000737:chemistry*
D006633:Histamine Antagonists; D026121:Indole Alkaloids; C488270:conicamin