Stereostructure of komodoquinone A, a neuritogenic anthracycline, from marine Streptomyces sp. KS3.
The absolute stereostructure of komodoquinone A (1), a neuritogenic anthracycline, which was isolated from a cultured marine Streptomyces sp. KS3, has been determined on the basis of chemical derivatization. Komodoquinone A (1) induces neuronal cell differentiation in the neuroblastoma cell line, Neuro 2A and arrests the cell cycle at the G1 phase. The effect of a solid-state medium on the production of 1 and its aglycone, komodoquinone B (2), was examined.
Itoh
Takuya
T
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Kinoshita
Masahiro
M
Wei
Hong
H
Kobayashi
Motomasa
M
D000818:Animals; D018943:Anthracyclines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000880:Anthraquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology; D045744:Cell Line, Tumor; D005285:Fermentation; D051379:Mice; D012623:Seawater / Q000382:microbiology; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry* / Q000254:growth & development
D018943:Anthracyclines; D000880:Anthraquinones; C481241:komodoquinone A