Peptide Epitalon activates chromatin at the old age.
OBJECTIVES and design. We have studied the effect of synthetic peptide Epitalon on the activity of ribosomal genes, denaturation parameters of total heterochromatin, polymorphism of structural C-heterochromatin and the variability of facultative heterochromatin in cultured lymphocytes of persons aged 76-80 years.


RESULTS
The obtained data demonstrate that Epitalon induces the activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin and the release of genes repressed due to the age-related condensation of euchromatic chromosome regions.


CONCLUSIONS
Epitalon has shown its ability to activate chromatin by modifying heterochromatin and heterochromatinized chromosome regions in the cells of older persons.
Khavinson
Vladimir Kh
VKh
St Petersburg Institute of Bioregulation and Gerontology of the North-Western Branch of the Russian Academy of Medical Sciences, Russia. khavinson@gerontology.ru
Lezhava
Teimuraz A
TA
Monaselidze
Jamlet R
JR
Jokhadze
Tinatin A
TA
Dvalishvili
Nana A
NA
Bablishvili
Nino K
NK
Trofimova
Svetlana V
SV
D000368:Aged; D000375:Aging / Q000502:physiology*; D002478:Cells, Cultured; D022041:Euchromatin / Q000187:drug effects / Q000235:genetics; D006570:Heterochromatin / Q000187:drug effects* / Q000235:genetics*; D006358:Hot Temperature; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D009842:Oligopeptides / Q000494:pharmacology*; D011489:Protein Denaturation; D012269:Ribosomal Proteins / Q000235:genetics; D015533:Transcriptional Activation / Q000187:drug effects
D022041:Euchromatin; D006570:Heterochromatin; D009842:Oligopeptides; D012269:Ribosomal Proteins; C421253:alanyl-glutamyl-aspartyl-glycine