title: Fibroblast growth factor receptor-1 interacts with the T-cell receptor signalling pathway.
abstract: Fibroblast growth factor receptors are expressed by some T cells, and provide costimulation for these cells. Such receptors allow T cells to respond to fibroblast growth factors expressed in response to injury and inflammation and may provide a mechanism for 'context-dependent' responses to antigens within the local microenvironment. The mechanisms by which fibroblast growth factor receptors might interact with the TCR signalling pathway are not defined. Here we show that the TCR and fibroblast growth factor receptors co-localize during combined stimulation. Signalling via fibroblast growth factor receptors alone results in phosphorylation of Lck and induces nuclear translocation of nuclear factors of activated T cells. Combined stimulation via fibroblast growth factor receptors and the TCR synergistically enhances the activation of nuclear factors of activated T cells. The results suggest that peptide growth factors produced at sites of injury and inflammation can contribute to the outcome of T-cell encounters with antigen.
authors.affiliation: Department of Medicine, Vanderbilt University Medical School, Nashville, USA.
authors.forename: Victor M
authors.initials: VM
authors.lastname: Byrd
authors.forename: Dawn M
authors.initials: DM
authors.lastname: Kilkenny
authors.forename: Michael M
authors.initials: MM
authors.lastname: Dikov
authors.forename: Martha B
authors.initials: MB
authors.lastname: Reich
authors.forename: Jonathan V
authors.initials: JV
authors.lastname: Rocheleau
authors.forename: Wade J
authors.initials: WJ
authors.lastname: Armistead
authors.forename: James W
authors.initials: JW
authors.lastname: Thomas
authors.forename: Geraldine G
authors.initials: GG
authors.lastname: Miller
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000187:drug effects; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D017252:CD3 Complex / Q000276:immunology; D002462:Cell Membrane / Q000378:metabolism; D005346:Fibroblast Growth Factors / Q000494:pharmacology; D006801:Humans; D019169:Jurkat Cells; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000187:drug effects / Q000378:metabolism; D050778:NFATC Transcription Factors / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000032:analysis / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D017252:CD3 Complex; D050778:NFATC Transcription Factors; D011948:Receptors, Antigen, T-Cell; D005346:Fibroblast Growth Factors; D051496:Receptor, Fibroblast Growth Factor, Type 1; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck)