title: Surgical feasibility of ipsilateral multifocal non-small cell lung cancer in different lobes: excellent survival in node-negative subgroup.
abstract: OBJECTIVE
  The management of ipsilateral multifocal non-small cell lung cancer (NSCLC) in different lobes is still controversial. We analyzed our surgical results and the prognostic factors with the findings of other studies and evaluated the surgical feasibility.
  
  
  METHODS
  Between January 1, 1983 and December 31, 2001, 1408 patients underwent operation for primary NSCLC, including 20 patients who received complete resections for multifocal NSCLC of the same histological type in ipsilateral different lobes.
  
  
  RESULTS
  The 1-, 2- and 5-year survival rate of the 20 patients were 60.0, 39.3 and 28.1%, respectively. There were no statistically significant differences in T-status, gender, pathological type, and stage. An excellent 5-year survival rate of 66.7% (median, 101 months) in the group without node involvement was found (N0 vs. N1+2, P=0.0872).
  
  
  CONCLUSIONS
  Our data suggest that surgical resection is mandatory in patients with ipsilateral multifocal NSCLC when there is no evidence of node metastasis.
authors.affiliation: Division of Thoracic Surgery, Department of Surgery, Taichung Veterans General Hospital, #160, Sec. 3, Taichung-Kang Road, Taichung, 407, Taiwan.
authors.forename: Yung Wei
authors.initials: YW
authors.lastname: Tung
authors.forename: Chung Ping
authors.initials: CP
authors.lastname: Hsu
authors.forename: Sen Ei
authors.initials: SE
authors.lastname: Shai
authors.forename: Jiun Yi
authors.initials: JY
authors.lastname: Hsia
authors.forename: Shyh Sheng
authors.initials: SS
authors.lastname: Yang
authors.forename: Chih Yi
authors.initials: CY
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome