title: Iron deficiency anemia and restless legs syndrome: is there an electrophysiological abnormality?
abstract: OBJECTIVE
  The pathogenesis of restless legs syndrome (RLS) is unknown. Although iron deficiency anemia (IDA) is related with RLS, the mechanism of this relationship is still unknown. Therefore, we decided to examine some neurophysiological parameters that reflect the function of brainstem, spinal cord and peripheral nervous system.
  
  
  METHODS
  34 patients diagnosed with IDA at the hematology department were questioned with a structured battery for RLS and additional symptoms. Of those, 14 patients had symptoms of RLS, while remaining 20 had no signs of this disorder. In both groups, electrophysiological examination including motor and sensory nerve conduction, F-responses, H-reflex, blink-reflex, and mixed nerve silent periods was performed.
  
  
  RESULTS
  Neurological examination of all patients was normal. The two groups were identical for age and sex, and the difference between both groups concerning motor and sensory nerve conduction, F-wave, H-reflex, blink-reflex, and mixed nerve silent periods was insignificant.
  
  
  CONCLUSIONS
  Results suggest that IDA does not cause electrophysiological changes in the peripheral nerves, spinal cord and brainstem, and therefore, measurement of these parameters in IDA patients does not seem effective for the confirmation of RLS.
authors.affiliation: Department of Neurology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey. aakyol59@hotmail.com
authors.forename: Ali
authors.initials: A
authors.lastname: Akyol
authors.forename: Nefati
authors.initials: N
authors.lastname: Kiylioglu
authors.forename: Gurhan
authors.initials: G
authors.lastname: Kadikoylu
authors.forename: Ali Zahit
authors.initials: AZ
authors.lastname: Bolaman
authors.forename: Nihat
authors.initials: N
authors.lastname: Ozgel
mesh_terms: D000328:Adult; D000368:Aged; D018798:Anemia, Iron-Deficiency / Q000150:complications / Q000503:physiopathology*; D001767:Blinking / Q000502:physiology; D001933:Brain Stem / Q000503:physiopathology*; D004576:Electromyography; D005260:Female; D006181:H-Reflex / Q000502:physiology; D006801:Humans; D007866:Leg / Q000294:innervation; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation; D009460:Neurologic Examination; D009475:Neurons, Afferent / Q000502:physiology; D010525:Peripheral Nerves / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012148:Restless Legs Syndrome / Q000209:etiology / Q000503:physiopathology*; D013116:Spinal Cord / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000502:physiology