title: Initial pharmacokinetic, safety and efficacy evaluation of nasal morphine gluconate for breakthrough pain in cancer patients.
abstract: Patients with controlled background pain associated with cancer frequently also experience episodes of moderate to severe intensity breakthrough pain. Opioid pharmacotherapy, particularly with oral morphine, remains the cornerstone for the management of cancer pain. Nasal administration of opioids provides a mechanism for more rapid drug absorption and more rapid onset of pain relief compared with oral dosing. This non-randomized, open-label, uncontrolled investigation evaluated the pharmacokinetics, safety and efficacy of a single 40 mg dose of nasal morphine gluconate, administered to cancer patients in response to an episode of breakthrough pain. Single dose nasal morphine gluconate administered to 11 patients was associated with effective plasma morphine concentrations (mean C(max) 64 ng/ml; range 33.8-121 ng/ml) and low plasma morphine metabolites (morphine-6-glucuronide mean C(max) 114 ng/ml; range 46-189 ng/ml; morphine-3-glucuronide mean C(max) 572 ng/ml; range 257-990 ng/ml). Side effects were minor and limited to nasal irritation. Patients reported rapid onset of pain relief (perceptible pain relief achieved in 10/11 patients, time to onset 2.4+/-2.1 min; and meaningful pain relief, achieved in five patients, 6.8+/-7.3 min to onset, mean t(max) 0.36 h). Pain intensity scores were significantly reduced at all times after dosing; pain relief scores were unchanged. Patient satisfaction ratings were high. These results show that nasal morphine has rapid absorption and apparent onset of effect. Additional multi-dose, dose-ranging and placebo-controlled studies of nasal morphine for cancer pain are warranted.
authors.affiliation: Department of Anesthesiology, University of Washington, Box 356540, 1959 NE Pacific St., Seattle, WA 98195, USA Department of Medicinal Chemistry, University of Washington, Seattle, WA, USA.
authors.forename: Dermot
authors.initials: D
authors.lastname: Fitzgibbon
authors.forename: Donna
authors.initials: D
authors.lastname: Morgan
authors.forename: Deanna
authors.initials: D
authors.lastname: Dockter
authors.forename: Chris
authors.initials: C
authors.lastname: Barry
authors.forename: Evan D
authors.initials: ED
authors.lastname: Kharasch
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects* / Q000097:blood; D009369:Neoplasms / Q000097:blood / Q000150:complications*; D010146:Pain / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D018709:Statistics, Nonparametric
chemical_list: D009020:Morphine