Synthesis and antiviral activity of novel trans-2,2-dimethyl cyclopropyl nucleosides.
Novel trans-2,2-dimethylcyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate, 3, was synthesized via five steps from ethyl chrysanthemate and condensed with purine bases using the Mitsunobu reaction to give six cyclopropyl nucleosides. These synthesized nucleosides did not show any significant antiviral activity against HSV-1, HSV-2, EMCV, Cox B3, or VSV, at concentrations up to 100 microM.
Kook
Min Chul
MC
College of Pharmacy, Chonnam National University, Kwangju 500-757, Korea.
Choi
Bo Gil
BG
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004686:Encephalomyocarditis virus / Q000187:drug effects / Q000254:growth & development; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000254:growth & development; D018258:Herpesvirus 2, Human / Q000187:drug effects / Q000254:growth & development; D009705:Nucleosides / Q000138:chemical synthesis* / Q000494:pharmacology*
D000998:Antiviral Agents; D009705:Nucleosides