A highly enantioselective phase-transfer catalyzed epoxidation of enones with a mild oxidant, trichloroisocyanuric acid.
The enantioselective epoxidation can be carried out using trichloroisocyanuric acid (TCCA) as oxidant in the presence of chiral quaternary ammonium salt as a phase-transfer catalyst; treatment of chalcone derivatives with TCCA under mild conditions afforded the corresponding epoxy ketones in good yields with moderate to excellent enantioselectivities of up to 96%.
Ye
Jinxing
J
Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 161 Zhongshan Road, Dalian 116011, China. jinxingye@dicp.ac.cn
Wang
Yongcan
Y
Liu
Renhua
R
Zhang
Guofu
G
Zhang
Qing
Q
Chen
Jiping
J
Liang
Xinmiao
X