[Effect of GABA on phosphoinositide cycle and membrane lipid modification in the brain synaptosomes of rats in hypokinesia].
The influence of a 30-day hypokinesia on the phosphoinositide cycle (PIC) initiation and on the inclusion of [14C]-arachidonic acid into cerebral synaptosome phospholipids was studied in rats. The results show that the catabolism of phospholipids prevails on the background of signal transduction in synaptosomes on the 30th day of hypokinesia. The effect of gamma-aminobutyric acid (GABA) is manifested by a sharp increase in the PIC activity 5 sec upon initiation and leads to normalization of the PIC activity in the late stage (5 min).
Akopian
V P
VP
Department of Pharmacology, Yerevan State Medical University, ul. Koryuna 2, Erevan, 375025 Armenia.
Melkonian
K V
KV
Tadevosian
Iu V
IuV
Batikian
T B
TB
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D018476:Hypokinesia / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism; D051381:Rats; D018080:Receptors, GABA-B / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D008563:Membrane Lipids; D010716:Phosphatidylinositols; D018080:Receptors, GABA-B; D016718:Arachidonic Acid; D005680:gamma-Aminobutyric Acid