Acute respiratory distress syndrome induced by rifampicin with high levels of neutrophil and eosinophil products in bronchoalveolar lavage fluid.
We reported a case with acute respiratory distress syndrome (ARDS) caused by rifampicin during therapy for pulmonary tuberculosis. A high level of eosinophil cationic protein in bronchoalveolar lavage fluid (BALF) was detected as well as interleukin-8 and neutrophil elastase. Based on these results together with the positive result of the drug lymphocyte-stimulating test, we concluded that rifampicin was the causative drug leading to ARDS. Corticosteroid therapy resulted in clinical improvement and resolution of the pulmonary infiltrates on the chest radiograph without the recurrence of pulmonary tuberculosis.
Ashitani
Jun-Ichi
J
Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan. fwkc5913@mb.infoweb.ne.jp
Yanagi
Shigehisa
S
Arimura
Yasuji
Y
Sano
Arisa
A
Mukae
Hiroshi
H
D000368:Aged; D000369:Aged, 80 and over; D000904:Antibiotics, Antitubercular / Q000009:adverse effects*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis; D008297:Male; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000503:physiopathology; D012293:Rifampin / Q000009:adverse effects*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
D000904:Antibiotics, Antitubercular; D018836:Inflammation Mediators; D012293:Rifampin