title: Genomic characterisation of the severe acute respiratory syndrome coronavirus of Amoy Gardens outbreak in Hong Kong.
abstract: Severe acute respiratory syndrome (SARS) is a global health concern. In Hong Kong, two major outbreaks, one hospital based and the other in the Amoy Gardens apartments, were identified. The frequency of diarrhoea, admission to intensive care, and mortality differed significantly between the two outbreaks. We did genomic sequencing for viral isolates from five Amoy Gardens patients. The virus sequence was identical in four of these five patients. The sequence data from one hospital case and the four identical community cases had only three nucleotide differences. Alterations in the SARS coronavirus genome are unlikely to have caused the distinctive clinical features of the Amoy Gardens patients, and these results highlight the importance of non-viral genomic factors in this outbreak.
authors.affiliation: Department of Chemical Pathology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China.
authors.forename: S S C
authors.initials: SS
authors.lastname: Chim
authors.forename: S K W
authors.initials: SK
authors.lastname: Tsui
authors.forename: K C A
authors.initials: KC
authors.lastname: Chan
authors.forename: T C C
authors.initials: TC
authors.lastname: Au
authors.forename: E C W
authors.initials: EC
authors.lastname: Hung
authors.forename: Y K
authors.initials: YK
authors.lastname: Tong
authors.forename: R W K
authors.initials: RW
authors.lastname: Chiu
authors.forename: E K O
authors.initials: EK
authors.lastname: Ng
authors.forename: P K S
authors.initials: PK
authors.lastname: Chan
authors.forename: C M
authors.initials: CM
authors.lastname: Chu
authors.forename: J J Y
authors.initials: JJ
authors.lastname: Sung
authors.forename: J S
authors.initials: JS
authors.lastname: Tam
authors.forename: K P
authors.initials: KP
authors.lastname: Fung
authors.forename: M M Y
authors.initials: MM
authors.lastname: Waye
authors.forename: C Y
authors.initials: CY
authors.lastname: Lee
authors.forename: K Y
authors.initials: KY
authors.lastname: Yuen
authors.forename: Y M D
authors.initials: YM
authors.lastname: Lo
mesh_terms: D001483:Base Sequence / Q000235:genetics; D003428:Cross Infection / Q000821:virology; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D016679:Genome, Viral; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D045473:Severe acute respiratory syndrome-related coronavirus / Q000235:genetics*; D045169:Severe Acute Respiratory Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology*