title: GSTM1 polymorphism and oral squamous cell carcinoma.
abstract: We investigated the frequency of the GSTM1 genotypes in 70 Brazilian patients with oral squamous cell carcinoma (OSCC) and 82 age-sex matched controls. The GSTM1 genotypes were studied by PCR-based methods. The frequency of male patients with OSCC and null for the GSTM1 (70.5%) was statistically different from the male patients from the control group (48.5%) (Odds Ratio, OR=2.53, 95% CI=1.22-5.24, P<0.05). The frequency of the GSTM1 null genotype (0/0) in the group with OSCC (65.7%) was statistically different from the controls (48.7%) (OR=2.01, 95% CI=1.04-3.88, P<0.05). The prevalence of GSTM1 deficiency (null) was significantly higher for patients with oral cancer of the floor of the mouth (OR=3.67, 95% CI=1.11-12.11, P<0.05). In conclusion, the GSTM1 null genotype may increase the risk for OSCC development.
authors.affiliation: Departmento de Patologia e Cirurgia, Faculdade de Odontologia, Av Antônio Carlos, 6627, Belo Horizonte, 31270-901, Brazil.
authors.forename: Sérgio Neves
authors.initials: SN
authors.lastname: Drummond
authors.forename: Luiz
authors.initials: L
authors.lastname: De Marco
authors.forename: Júlio Carlos Motta
authors.initials: JC
authors.lastname: Noronha
authors.forename: Ricardo Santiago
authors.initials: RS
authors.lastname: Gomez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D005982:Glutathione Transferase