Tolerance of the fetus by the maternal immune system: role of inflammatory mediators at the feto-maternal interface.
The adaptive immune system of placental mammals has evolved to tolerate the fetus. Rejection of the fetus by adaptive immune responses is therefore a rare event, with abortion being caused more frequently by inflammation in the placenta. This review will cover recent aspects of immune privilege and the innate immune system at the feto-maternal interface, citing examples of the role played by microbial infections in fetal demise.
Kanellopoulos-Langevin
Colette
C
Institut Jacques Monod, CNRS UMR 7592, Universités Paris 6 & 7, 2 place Jussieu, 75251 Paris Cedex 5, France. kanellopoulos@ijm.jussieu.fr
Caucheteux
Stéphane M
SM
Verbeke
Philippe
P
Ojcius
David M
DM
D005260:Female; D005313:Fetal Death / Q000276:immunology / Q000382:microbiology; D005333:Fetus / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007113:Immunity, Innate / Q000276:immunology; D018836:Inflammation Mediators / Q000276:immunology*; D011247:Pregnancy / Q000276:immunology*
D018836:Inflammation Mediators