Neurological deficit and disturbances in higher nervous activity during modeling of perinatal hypoxic-ischemic damage to the central nervous system in rat pups.
Seven-day-old Wistar rat pups were subjected to unilateral occlusion of the common cerebral artery and maintained in oxygen-low atmosphere. Neurological and behavioral changes were monitored for 12 weeks. The survival rate of treated animals was 90%. Body weight gain in these rats was lower than in the control. Neurological deficit was maximum 1 week after treatment and slightly regressed by the 12th week. Locomotor activity in treated rats was higher than in controls. Administration of ketamine in subanesthetic doses caused permanent ipsilateral rotational asymmetry in animals. Spatial disorientation and cognitive deficit in rats with hypoxic-ischemic damage to the central nervous system were revealed in passive avoidance, Y-maze, and rotarod tests. The total area of the hemisphere decreased, while the area of the lateral cerebral ventricle increased at the side of occlusion over the first 4-5 weeks of postnatal development. The size of the ipsilateral hemisphere remained low in adult animals.
Lebedev
S V
SV
V. P. Serbskii State Research Center for Social and Forensic Psychiatry, Moscow.
Volodin
N N
NN
Blinov
D V
DV
Lazarenko
I P
IP
Rogatkin
S O
SO
Chekhonin
V P
VP
D000818:Animals; D001522:Behavior, Animal; D001835:Body Weight; D001921:Brain / Q000473:pathology; D002490:Central Nervous System / Q000254:growth & development / Q000473:pathology*; D002493:Central Nervous System Diseases / Q000378:metabolism; D002536:Cerebral Arteries / Q000473:pathology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005260:Female; D000860:Hypoxia; D020925:Hypoxia-Ischemia, Brain / Q000473:pathology*; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D009420:Nervous System / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D018691:Excitatory Amino Acid Antagonists; D007649:Ketamine; D010100:Oxygen