title: Novel synthesis of 3-azabicyclo[3.1.0]hexanes by unusual palladium(0)-catalyzed cyclopropanation of allenenes.
abstract: Novel stereoselective synthesis of 3-azabicyclo[3.1.0]hexanes from allenenes is presented. Treatment of N-protected 4-alkyl-4-(N-allyl)amino allenes with allyl carbonate and a catalytic amount of Pd(2)(dba)(3).CHCl(3) in MeCN leads to stereoselective formation of the 3-azabicyclo[3.1.0]hexane framework in moderate to good yields. [reaction: see text]
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ohno
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Takeoka
authors.forename: Kumiko
authors.initials: K
authors.lastname: Miyamura
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Kadoh
authors.forename: Tetsuaki
authors.initials: T
authors.lastname: Tanaka