title: Coloration of fundus lesions in bilateral diffuse uveal melanocytic proliferation.
abstract: OBJECTIVE
  To report differences in the coloration of fundus lesions between Asian and Caucasian patients with bilateral diffuse uveal melanocytic proliferation (BDUMP).
  
  
  METHODS
  This syndrome was detected in 2 Japanese patients, 69 and 73 years old, with lung cancer who visited our department complaining of visual disturbances. The coloration of the fundus lesions was investigated in these 2 patients.
  
  
  RESULTS
  The fundus lesions in the first patient appeared gray or grayish-brown in color at the first visit. Six months later, the fundus appeared as a mixture of white to dark-brown lesions. The fundus in the second patient exhibited a mixture of white, gray, and dark-brown lesions from the first visit.
  
  
  CONCLUSIONS
  The fundus lesions in these BDUMP patients appeared gray or grayish-brown in color at the early stage of the disease, probably because of the abundance of melanin pigments in the uveal melanocytes. At the advanced stage, the fundus exhibited a mixture of dark-brown lesions due to melanin deposits and white, depigmented lesions caused by atrophy and/or necrosis of the melanocytes.
authors.affiliation: Department of Ophthalmology, Osaka City General Hospital, Osaka, Japan.
authors.forename: Saiyuu
authors.initials: S
authors.lastname: Yu
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Ikeda
authors.forename: Naohiro
authors.initials: N
authors.lastname: Ikeda
authors.forename: Osamu
authors.initials: O
authors.lastname: Mimura
authors.forename: Keiko
authors.initials: K
authors.lastname: Sato
mesh_terms: D000368:Aged; D044466:Asian People; D003116:Color; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D008544:Melanocytes / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000208:ethnology* / Q000473:pathology*; D014602:Uvea / Q000473:pathology*