title: Association of intercellular adhesion molecule-1 gene with type 1 diabetes.
abstract: Intercellular adhesion molecule-1 (ICAM-1) functions via its ligands, the leucocyte integrins, in adhesion of immune cells to endothelial cells and in T cell activation. The third immunoglobulin-like extracellular domain binds integrin Mac-1 and contains a common non-conservative aminoacid polymorphism, G241R. Phenotypically, ICAM-1 has been associated with type 1 diabetes, a T-cell-mediated autoimmune disease. We assessed two independent datasets, and noted that R241 was associated with lower risk of type 1 diabetes than is G241 (3695 families, relative risk 0.91, p=0.03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments.
authors.affiliation: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, CB2 2XY, Cambridge, UK. sergey.nejentsev@cimr.cam.ac.uk
authors.forename: Sergey
authors.initials: S
authors.lastname: Nejentsev
authors.forename: Cristian
authors.initials: C
authors.lastname: Guja
authors.forename: Rose
authors.initials: R
authors.lastname: McCormack
authors.forename: Jason
authors.initials: J
authors.lastname: Cooper
authors.forename: Joanna M M
authors.initials: JM
authors.lastname: Howson
authors.forename: Sarah
authors.initials: S
authors.lastname: Nutland
authors.forename: Helen
authors.initials: H
authors.lastname: Rance
authors.forename: Neil
authors.initials: N
authors.lastname: Walker
authors.forename: Dag
authors.initials: D
authors.lastname: Undlien
authors.forename: Kjersti S
authors.initials: KS
authors.lastname: Ronningen
authors.forename: Eva
authors.initials: E
authors.lastname: Tuomilehto-Wolf
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
authors.forename: Constantin
authors.initials: C
authors.lastname: Ionescu-Tirgoviste
authors.forename: Edwin A M
authors.initials: EA
authors.lastname: Gale
authors.forename: Polly J
authors.initials: PJ
authors.lastname: Bingley
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Gillespie
authors.forename: David A
authors.initials: DA
authors.lastname: Savage
authors.forename: Dennis J
authors.initials: DJ
authors.lastname: Carson
authors.forename: Chris C
authors.initials: CC
authors.lastname: Patterson
authors.forename: A Peter
authors.initials: AP
authors.lastname: Maxwell
authors.forename: John A
authors.initials: JA
authors.lastname: Todd
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide
chemical_list: D018799:Intercellular Adhesion Molecule-1