Comparison of several formulas to assess insulin action in the fasting state with the hyperglycemic-hyperinsulinemic clamp technique in healthy individuals.
BACKGROUND
The aim of this study was to correlate several formulas to assess insulin action in the fasting state with the hyperglycemic-hyperinsulinemic clamp method in healthy individuals.


METHODS
A cross-sectional study was carried out in 33 healthy, non-obese volunteers. A hyperglycemic-hyperinsulinemic clamp technique was performed and the following formulas to assess insulin action in the fasting state were calculated: reciprocal insulin, glucose to insulin ratio, homeostasis model analysis, Raynaud index, Belfiore index, reciprocal of fasting insulin resistance index and quantitative insulin sensitivity check index. Pearson correlation was used to correlate the above mentioned formulas with the clamp method.


RESULTS
There were significant correlations between results of the several formulas and those obtained with the clamp technique. The reciprocal of insulin index had better correlation with the clamp method.


CONCLUSIONS
All formulas evaluated to assess insulin action in the fasting state had a significant correlation with the hyperglycemic clamp technique.
González-Ortiz
Manuel
M
Medical Research Unit in Clinical Epidemiology, West National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico. uiec@prodigy.net.mx
Martínez-Abundis
Esperanza
E
D000293:Adolescent; D000328:Adult; D003430:Cross-Sectional Studies; D005215:Fasting / Q000097:blood*; D005260:Female; D015309:Glucose Clamp Technique / Q000379:methods*; D006801:Humans; D006943:Hyperglycemia; D006946:Hyperinsulinism; D007328:Insulin / Q000494:pharmacology*; D008297:Male
D007328:Insulin