Increased serum levels of interleukin-6 in malnourished patients with colorectal cancer.
Peri-operative serum levels of interleukin-6 (IL-6) were determined in 62 patients who underwent resection of colorectal cancer to clarify the relationship between nutritional status and IL-6 response. Patients were divided into two groups based on creatinine height index: malnourished group (n=13) and normally nourished group (n=49). The preoperative median serum level of IL-6 in the malnourished group was significantly higher than in the normally nourished group (P=0.041). The postoperative median serum level of IL-6 in the malnourished group also tended to be higher. In conclusion, the peri-operative IL-6 response may be activated in malnourished colorectal cancer patients.
Nakagoe
Tohru
T
First Department of Surgery, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852 8501, Japan. nakagoe@net.nagasaki-u.ac.jp
Tsuji
Takashi
T
Sawai
Terumitsu
T
Tanaka
Kenji
K
Hidaka
Shigekazu
S
Shibasaki
Shin ichi
Si
Nanashima
Atsushi
A
Ohbatake
Masayuki
M
Yamaguchi
Hiroyuki
H
Yasutake
Toru
T
Sugawara
Kazuyuki
K
Inokuchi
Naoko
N
Kamihira
Shimeru
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood* / Q000601:surgery; D003404:Creatinine / Q000652:urine; D004032:Diet; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D044342:Malnutrition / Q000097:blood*; D008875:Middle Aged; D009752:Nutritional Status; D015854:Up-Regulation
D015415:Biomarkers; D015850:Interleukin-6; D003404:Creatinine