title: New indole alkaloids from the North Sea bacterium Vibrio parahaemolyticus Bio249.
abstract: Several bis- and tris-indole derivatives were isolated from a North Sea bacterium that was closely related to Vibrio parahaemolyticus (98% homology). 1,1,3-Tris(3-indolyl)butane (3) is a new compound, and 3,3-bis(3-indolyl)butane-2-one (1a), arundine (1b), and 1,1,1-tris(3-indolyl)methane (2a) were isolated from a microorganism for the first time here. Additionally, many other known compounds were obtained from the ethyl acetate extract of the culture. Their structures were established on the basis of various spectral data, and their origin is discussed. All compounds were inactive against a range of bacteria and fungi.
authors.affiliation: Department of Organic Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
authors.forename: Ravikanth
authors.initials: R
authors.lastname: Veluri
authors.forename: Imelda
authors.initials: I
authors.lastname: Oka
authors.forename: Irene
authors.initials: I
authors.lastname: Wagner-Döbler
authors.forename: Hartmut
authors.initials: H
authors.lastname: Laatsch
mesh_terms: D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D009089:Mucor / Q000187:drug effects; D009659:North Sea; D019906:Nuclear Magnetic Resonance, Biomolecular; D013211:Staphylococcus aureus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects; D014736:Vibrio parahaemolyticus / Q000737:chemistry*
chemical_list: D026121:Indole Alkaloids