title: [Effect of iron on peroxidation and non-enzymatic glycation in diabetic rats].
abstract: SD rats were peritoneally injected with streptozotocin to establish diabetes mellitus animal model. The changes of nonenzymatic glycation and peroxidation in rats supplemented with low iron high iron during five weeks were investigated. It was found that MDA in serum or renal cortex but not glycated hemoglobin, glycated LDL, renal cortical AGEs increased significantly after supplementation of high iron in diabetic rats. There was no change in serum MDA, renal cortical MDA, glycated hemoglobin, glycated LDL and AGEs after supplementation of low iron in diabetic rats. The results suggested that peroxidation could be enhanced obviously by supplementation of high iron so that chronic complications could be promoted by high dose iron in diabetic rats.
authors.affiliation: Department of Nutrition, No. 411 Hospital of PLA, Shanghai 200081, China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Qian
authors.forename: Junsheng
authors.initials: J
authors.lastname: Guo
authors.forename: Changyun
authors.initials: C
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Niu
authors.forename: Shengqiu
authors.initials: S
authors.lastname: Cheng
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D007501:Iron / Q000008:administration & dosage / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D017127:Glycation End Products, Advanced; D008315:Malondialdehyde; D007501:Iron