title: [The correlation study of CT enhancement, intratumoral microvessel density and pathological grades in pancreatic carcinoma].
abstract: OBJECTIVE
  The purpose of this work was to study the correlation of pancreatic phase CT enhancement, intratumoral microvessel density (MVD) and histopathological grades in pancreatic carcinoma and to evaluate the relationship between CT enhancement degree and the malignancy degree of pancreatic carcinoma.
  
  
  METHODS
  34 patients with pancreatic carcinoma underwent CT scanning before resection. The enhancement degrees and forms of tumor were observed in pancreatic-phase. The operational sample was stained with HE and CD34 marked by immunohistochemistry. MVD and histopathological grades of pancreatic carcinoma were examined. CT enhancement of the tumor, MVD counting in hot spots areas of neoplastic parenchymal cells and pathological grades of pancreatic carcinoma were comparatively analyzed.
  
  
  RESULTS
  Highly differentiated pancreatic adenocarcinoma was identified in 16 patients, moderately differentiated tumor in 7 and poorly differentiated tumor in 11. Isodensity CT enhancement was demonstrated in 13 cases, slight low density enhancement in 9, slight low density enhancement along with small cyst lesion in 9 and slight low density enhancement along with large cyst lesion in 3. The counting of MVD with CD34 marked by immunohistochemistry in hot spot areas of neoplastic parenchyma cells were small in 10 cases, medium in 16 and large in 8. The pathological grades correlated with CT enhancement of tumor (r = 0. 785 7, P < 0.001). The pathological grade correlated with MVD counting of tumor (r = 0.361 3, P < 0.05). The CT enhancement of tumor correlated with MVD (r = 0.676 8, P < 0.001).
  
  
  CONCLUSIONS
  There was obvious and significant correlation between CT enhancement, pathological grades MVD numbers in the hot spot areas of tumor. The malignant degree of pancreatic carcinoma was inversely proportional to the extent of CT enhancement and inversely proportional to MVD numbers in the hot spot areas of tumor.
authors.affiliation: Department of Medical Imaging, Jinling Hospital, Nanjing University Medical School, Nanjing 210002, China.
authors.forename: Zhong-qiu
authors.initials: ZQ
authors.lastname: Wang
authors.forename: Jie-shou
authors.initials: JS
authors.lastname: Li
authors.forename: Guang-ming
authors.initials: GM
authors.lastname: Lu
authors.forename: Xin-hua
authors.initials: XH
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D011856:Radiographic Image Enhancement; D014057:Tomography, X-Ray Computed