Interference between avian endogenous ev/J 4.1 and exogenous ALV-J retroviral envelopes.
A new family of avian retroviral endogenous sequences designated ev/J or EAV-HP has been identified recently. Here an additional avian ev/J 4.1 endogenous sequence, ev/J 4.1 Rb, is reported. ev/J 4.1 Rb has the most extensive amino acid identity ever described for an endogenous envelope protein with the ALV-J avian leukosis virus. Here, we also demonstrate that ev/J 4.1 Rb functionally pseudotypes murine leukaemia virions and leads to a complete reciprocal interference with ALV-J envelopes. This is the first demonstration of such a high level of envelope interference between endogenous and exogenous avian retroviruses. Our results provide additional clues on the co-evolution of retroviral sequences among vertebrates.
Denesvre
Caroline
C
BASE, INRA Centre de Tours, 37380 Nouzilly, France.
Soubieux
Denis
D
BASE, INRA Centre de Tours, 37380 Nouzilly, France.
Pin
Gaelle
G
BASE, INRA Centre de Tours, 37380 Nouzilly, France.
Hue
Dominique
D
BASE, INRA Centre de Tours, 37380 Nouzilly, France.
Dambrine
Ginette
G
BASE, INRA Centre de Tours, 37380 Nouzilly, France.
D000595:Amino Acid Sequence; D001354:Avian Leukosis Virus / Q000235:genetics* / Q000502:physiology; D020077:Endogenous Retroviruses / Q000235:genetics* / Q000502:physiology; D015752:Genes, env; D009052:Leukemia Virus, Murine / Q000235:genetics; D008969:Molecular Sequence Data; D016865:Reassortant Viruses; D016415:Sequence Alignment; D014762:Viral Interference / Q000235:genetics*