Genetic association between the phospholipase A2 gene and unipolar affective disorder: a multicentre case-control study.
The co-segregation in one pedigree of bipolar affective disorder with Darier's disease whose gene is on chromosome 12q23-q24.1, and findings from linkage and association studies with the neighbouring gene of phospholipase A2 (PLA2) indicate that PLA2 may be considered as a candidate gene for affective disorders. All relevant genetic association studies, however, were conducted on bipolar patients. In the present study, the possible association between the PLA2 gene and unipolar affective disorder was examined on 321 unipolar patients and 604 controls (all personally interviewed), recruited from six countries (Belgium, Bulgaria, Croatia, Germany, Greece, and Italy) participating in the European Collaborative Project on Affective Disorders. After controlling for population group and gender, one of the eight alleles of the investigated marker (allele 7) was found to be more frequent among unipolar patients with more than three major depressive episodes than among controls (P<0.01); genotypic association was also observed, under the dominant model of genetic transmission (P<0.02). In addition, presence of allele 7 was correlated with a higher frequency of depressive episodes (P<0.02). These findings suggest that structural variations at the PLA2 gene or the chromosomal region around it may confer susceptibility for unipolar affective disorder.
Papadimitriou
George N
GN
Athens University Medical School, Department of Psychiatry, Eginition Hospital, Athens, Greece. gnpapad@med.uoa.gr
Dikeos
Dimitris G
DG
Souery
Daniel
D
Del-Favero
Jurgen
J
Massat
Isabelle
I
Avramopoulos
Dimitrios
D
Blairy
Sylvie
S
Cichon
Sven
S
Ivezic
Sladjana
S
Kaneva
Radka
R
Karadima
Georgia
G
Lilli
Roberta
R
Milanova
Vihra
V
Nöthen
Markus
M
Oruc
Lilijana
L
Rietschel
Marcella
M
Serretti
Alessandro
A
Van Broeckhoven
Christine
C
Stefanis
Costas N
CN
Mendlewicz
Julien
J
D016022:Case-Control Studies; D002874:Chromosome Mapping; D003866:Depressive Disorder / Q000235:genetics*; D005060:Europe; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D010741:Phospholipases A / Q000235:genetics*; D054467:Phospholipases A2
D010741:Phospholipases A; D054467:Phospholipases A2