title: Estrogen effect on some enzymes in female rats after downhill running.
abstract: The study investigates the effect of administered estrogen on plasma creatine kinase (CK) and lactate dehydrogenase (LD) levels in female ovariectomized rats after downhill running. Rats ovariectomized before sexual maturity were subcutaneously implanted with pellets containing 17 beta-estradiol or placebo. Three weeks later they were subjected to a 90-min intermittent downhill running protocol. Blood samples were obtained from the jugular vein immediately after and 72 h after exercise for determination of plasma CK, LD and 17 beta-estradiol levels. A two-way analysis of variance was used for data evaluation. Plasma CK and LD levels were significantly lower (p<0.05) in the estrogen-supplemented, ovariectomized animals which suggests that less muscle damage occurred compared to the controls immediately and 72 h after exercise. Estrogens may have a protective effect on muscle tissue possibly due to their antioxidant and membrane stabilizing properties.
authors.affiliation: Department of Physical Education and Sports Science, Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece. sotiriadou@yahoo.com
authors.forename: S
authors.initials: S
authors.lastname: Sotiriadou
authors.forename: A
authors.initials: A
authors.lastname: Kyparos
authors.forename: V
authors.initials: V
authors.lastname: Mougios
authors.forename: Ch
authors.initials: Ch
authors.lastname: Trontzos
authors.forename: G
authors.initials: G
authors.lastname: Sidiras
authors.forename: Ch
authors.initials: Ch
authors.lastname: Matziari
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D003402:Creatine Kinase / Q000097:blood*; D004958:Estradiol / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology*; D005080:Exercise Test; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D012420:Running / Q000502:physiology*; D013997:Time Factors
chemical_list: D004967:Estrogens; D004958:Estradiol; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase