Oral colon-specific drug delivery for bee venom peptide: development of a coated calcium alginate gel beads-entrapped liposome.
Colon-specific drug delivery systems (CDDSs) can be used to improve the bioavailability of protein and peptide drugs through the oral route. A novel formulation for oral administration using coated calcium alginate gel beads-entrapped liposome and bee venom peptide as a model drug has been investigated for colon-specific drug delivery in vitro. Drug release studies under conditions mimicking stomach to colon transit have shown that the drug was protected from being released completely in the physiological environment of the stomach and small intestine. The release rate of bee venom from the coated calcium alginate gel beads-entrapped liposome was dependent on the concentration of calcium and sodium alginate, the amount of bee venom in the liposome, as well as the coating. Furthermore, a human gamma-scintigraphy technique was used in vivo to determine drug delivery more precisely. The colonic arrival time of the tablets was found to be 4-5 h. The results clearly demonstrated that the coated calcium alginate gel beads-entrapped liposome is a potential system for colon-specific drug delivery.
Xing
Liu
L
Department of Pharmaceutical Science, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 100016, China.
Dawei
Chen
C
Liping
Xie
X
Rongqing
Zhang
Z
D000284:Administration, Oral; D000328:Adult; D000464:Alginates / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D001514:Bee Venoms / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D003106:Colon / Q000187:drug effects* / Q000378:metabolism; D016503:Drug Delivery Systems / Q000379:methods*; D005782:Gels; D020723:Glucuronic Acid / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D006603:Hexuronic Acids / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D008081:Liposomes; D008297:Male; D008863:Microspheres
D000464:Alginates; D001514:Bee Venoms; D005782:Gels; D006603:Hexuronic Acids; D008081:Liposomes; D020723:Glucuronic Acid