title: [Pathogenetic basis of the application of calcium antagonists in the treatment of recurrent peptic ulcer].
abstract: Examination of 150 ulcer patients determined that the exacerbation of the disease proceeds against the background of essential augmentation of calcium in the blood, which is most expressed at the acute phase of relapse, at the localization of ulcer in the duodenum, in men of young age. This is accompanied by the rising production of hydrochloric acid and pepsinogen, decrease of production of gastromucoproteins, hypermotor dyskinesia of stomach, hypocoagulation, infringement of microcirculation in the mucous coat of the gastroduodenal zone displayed as microthromboses, plasmorrhagias, hemorrhages. The inclusion of the calcium antagonist Corinfarum in the complex therapy reliably accelerates the liquidation of signs of relapse, reduces terms, increases the percentage of ulcer cicatrisation, and promotes normalization of stomach functions, calcium balance, hemostasis and microcirculation.
authors.affiliation: Tver State Medical Academy.
authors.forename: V V
authors.initials: VV
authors.lastname: Chernin
authors.forename: L A
authors.initials: LA
authors.lastname: Fomina
mesh_terms: D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000097:blood; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D005260:Female; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000188:drug therapy*; D055502:Secondary Prevention
chemical_list: D002121:Calcium Channel Blockers; D002118:Calcium