title: Normal values of left ventricular systolic and diastolic function derived from signal-averaged acoustic quantification waveforms: a multicenter study.
abstract: Automated border-detection techniques such as acoustic quantification have proven accurate and useful for quantifying left ventricular (LV) function. We acquired LV acoustic quantification waveforms from the parasternal short-axis window in 140 healthy patients in the age range of 16 to 78 years. Signal-averaged waveforms were analyzed for parameters of systolic and diastolic performance. The average fractional area change was 54 +/- 12%, and there were no significant changes in LV systolic function in the age range studied. There were significant changes in diastolic parameters with aging. The percentage of contribution to total LV filling occurring during atrial filling nearly tripled during the 6 decades studied, from 13% in the youngest cohort to 36% in the eighth decade of life. This study provides normal reference values for systolic and diastolic parameters of LV function determined from signal-averaged acoustic quantification waveforms acquired from the parasternal short-axis view in adult and adolescent patients over a wide age range.
authors.affiliation: Section of Cardiology, University of Chicago, Medical Center, Illinois 60637, USA. kspencer@medicine.bsd.uchicago.edu
authors.forename: Kirk T
authors.initials: KT
authors.lastname: Spencer
authors.forename: Victor
authors.initials: V
authors.lastname: Mor-Avi
authors.forename: Jim
authors.initials: J
authors.lastname: Kirkpatrick
authors.forename: John
authors.initials: J
authors.lastname: Gorcsan
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Kimball
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Monaghan
authors.forename: Julio E
authors.initials: JE
authors.lastname: Perez
authors.forename: Lynn
authors.initials: L
authors.lastname: Weinert
authors.forename: James
authors.initials: J
authors.lastname: Bednarz
authors.forename: Kathy
authors.initials: K
authors.lastname: Edelman
authors.forename: Betty
authors.initials: B
authors.lastname: Glascock
authors.forename: Jane
authors.initials: J
authors.lastname: Hancock
authors.forename: Chris
authors.initials: C
authors.lastname: Baumann
authors.forename: Roberto M
authors.initials: RM
authors.lastname: Lang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003971:Diastole / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013318:Stroke Volume; D013599:Systole / Q000502:physiology*; D016277:Ventricular Function, Left