title: Clostridium perfringens type A myonecrosis in a horse in Korea.
abstract: Acute hemorrhagic myonecrosis accompanied by severe inter- and intrafascicular edema and hemorrhage of the right gluteal area was diagnosed in a 13-year-old male thoroughbred horse. Once the muscular and fascicular changes were subsided, the horse then developed acute respiratory problem. Histologically, the lung had diffuse severe hemorrhage with mild neutrophilic infiltration. The cause of death was acute respiratory failure that is believed to occur secondary to toxaemic event. Alpha and beta2 toxin secreting Clostiridum perfringens type A was isolated from the muscle and lung. The diagnosis was based on the light microscopic examination, bacterial toxinotyping and toxin genotyping from the muscular and pulmonary lesion. Also, susceptibility of the isolates to antimicrobial agents was determined.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea.
authors.forename: Yang-Kyu
authors.initials: YK
authors.lastname: Choi
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Kang
authors.forename: Han-Sang
authors.initials: HS
authors.lastname: Yoo
authors.forename: Deog-Yong
authors.initials: DY
authors.lastname: Lee
authors.forename: Hyun-Chul
authors.initials: HC
authors.lastname: Lee
authors.forename: Dae-Yong
authors.initials: DY
authors.lastname: Kim
mesh_terms: D000818:Animals; D001427:Bacterial Toxins; D003015:Clostridium Infections / Q000473:pathology / Q000662:veterinary*; D003016:Clostridium perfringens / Q000502:physiology*; D004586:Electrophoresis; D004768:Enterotoxins; D017809:Fatal Outcome; D006652:Histological Techniques; D006734:Horse Diseases / Q000382:microbiology* / Q000473:pathology*; D006736:Horses; D007723:Korea; D008168:Lung / Q000473:pathology; D008297:Male; D009135:Muscular Diseases / Q000473:pathology / Q000662:veterinary*; D009336:Necrosis
chemical_list: D001427:Bacterial Toxins; D004768:Enterotoxins; C109896:cpb2 protein, Clostridium perfringens; C035598:enterotoxin, Clostridium