Characterization of murine leukemia virus restriction in mammals.
Restriction of murine leukemia virus (MLV) was examined in cells from a range of mammals. All nonmurine restrictions were saturable blocks to N-tropic MLV infection, and several were prior to reverse transcription. We demonstrate restriction in cells from bat and show that if we express the murine restriction factor Fv1 in human cells, then Fv1, not the human host, defines the stage at which infection is blocked.
Besnier
Caroline
C
Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, London W1T 4JF, United Kingdom.
Ylinen
Laura
L
Strange
Benjamin
B
Lister
Adrian
A
Takeuchi
Yasuhiro
Y
Goff
Stephen P
SP
Towers
Greg J
GJ
D000818:Animals; D002417:Cattle; D002460:Cell Line; D006224:Cricetinae; D006801:Humans; D009052:Leukemia Virus, Murine / Q000472:pathogenicity* / Q000502:physiology*; D008322:Mammals / Q000821:virology*; D051379:Mice; D041681:NIH 3T3 Cells; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
C103189:Fv1 protein, mouse; D011506:Proteins