Why do cells require heat shock proteins to survive heat stress?
The cellular response to heat stress includes the induction of a group of proteins called the Heat Shock Proteins, whose functions include the synthesis of the thermoprotectant trehalose, refolding of denatured proteins, and ubiquitin- and proteasome-dependent degradation. Recent studies show that simply increasing the activity of ubiquitin- and proteasome-dependent degradation can replace the essential functions played by the induction of heat shock proteins during a heat stress. These results suggest that accumulation of denatured or aggregated proteins is the reason for the loss of cell viability due to heat stress.
Riezman
Howard
H
Department of Biochemistry, Sciences II, 30 quai E. Ansermet, CH-1211 Geneva 4, Switzerland. Howard.Riezman@biochem.unige.ch
D002470:Cell Survival / Q000502:physiology; D003546:Cysteine Endopeptidases / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology; D006360:Heat-Shock Proteins / Q000378:metabolism*; D018869:Heat-Shock Response / Q000502:physiology*; D006801:Humans; D009097:Multienzyme Complexes / Q000378:metabolism; D009154:Mutation; D019636:Neurodegenerative Diseases / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D011489:Protein Denaturation; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D013107:Sphingolipids / Q000096:biosynthesis*; D025801:Ubiquitin / Q000378:metabolism*; D025822:Ubiquitin C / Q000378:metabolism
D006360:Heat-Shock Proteins; D009097:Multienzyme Complexes; D029701:Saccharomyces cerevisiae Proteins; D013107:Sphingolipids; C417885:UBI4 protein, S cerevisiae; D025801:Ubiquitin; D025822:Ubiquitin C; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex