title: June 2003: 33-year-old male with a frontal lobe mass.
abstract: The June 2003 COM. A 33-year-old male with a history of seizures was found to have an intra- and extra-axial frontal lobe mass. The histology of the resected tumor showed a meningioma with underlying meningioangiomatosis. Meningioangiomatosis (MA) is a benign intracortical plaque-like proliferation of meningothelial cells, microvasculature and fibroblast-like cells probably of hamartomatous origin. Very rarely, MA is associated with an overlying meningioma as in this case. When MA is accompanied by a meningioma, it is generally not associated with clinical evidence of neurofibromatosis. It is important to distinguish MA from an invasive meningioma, because of its favorable prognosis after resection.
authors.affiliation: Department of Pathology and Laboratory Medicine (Neuropathology), Cedars-Sinai Medical Center and UCLA School of Medicine, Los Angeles, Calif, USA.
authors.forename: G
authors.initials: G
authors.lastname: Iezza
authors.forename: C
authors.initials: C
authors.lastname: Loh
authors.forename: T H
authors.initials: TH
authors.lastname: Lanman
authors.forename: W H
authors.initials: WH
authors.lastname: Yong
mesh_terms: D000328:Adult; D050701:E2F6 Transcription Factor; D017352:Echo-Planar Imaging / Q000379:methods; D017034:Epilepsy, Frontal Lobe / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008579:Meningioma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D016518:Neurofibromatosis 2 / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D050701:E2F6 Transcription Factor; C491744:E2F6 protein, human; D019394:Ki-67 Antigen; D012097:Repressor Proteins; D014157:Transcription Factors