Cross-reactivity between Anisakis simplex sensitization and visceral larva migrans by Toxocara canis.
The aim of this work was to study cross-reactivity in the diagnosis of two related ascaridosis. Nineteen patients diagnosed with recidivous acute urticaria (RAU) caused by Anisakis simplex and 26 patients diagnosed with visceral larva migrans (VLM) caused by Toxocara canis were studied employing commercial diagnostic kits and "in house" assay kits. Cross-reactivity observed was greater when using "in house" assay kits, suggesting that T. canis excretory-secretory antigens were not only recognized by antibodies from patients with RAU but with greater intensity compared to the A. simplex excretory-secretory antigens.
Perteguer
M J
MJ
Departamento de Parasitología, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain.
Cuéllar
C
C
Guillén
J L
JL
Aguila
C
C
Fenoy
S
S
Chivato
T
T
Laguna
R
R
D000818:Animals; D017129:Anisakiasis / Q000175:diagnosis* / Q000276:immunology; D017163:Anisakis / Q000276:immunology*; D000947:Antigens, Helminth / Q000276:immunology*; D003429:Cross Reactions; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007816:Larva Migrans, Visceral / Q000175:diagnosis* / Q000276:immunology; D011933:Reagent Kits, Diagnostic; D017166:Toxocara canis / Q000276:immunology*
D000947:Antigens, Helminth; D011933:Reagent Kits, Diagnostic