title: The use of botulinum toxin type A treatment in children with spasticity.
abstract: The current modalities in managing spastic children have some limitations; thus, alternative therapeutic agents are in need. The purpose of this study is to investigate whether intramuscular botulinum toxin type A administration may be an alternative agent in the treatment of children with cerebral palsy. Eighteen children who were aged between 3 and 17 years and manifested cerebral palsy were administered intramuscular botulinum toxin type A with a total dose of 6 U/kg body weight. Outcome measurements were determined with four methods, including Ashworth Spasticity Scale, standardized videotape assessments, observational gait analysis, and walking velocity. Ashworth Spasticity Scale and videotape assessments were statistically significant before and after treatment in all muscles (P < 0.001). The best improvement in video gait analysis was evident at week 8. The botulinum toxin type A injections yielded an improved walking velocity at all visits. The observational gait analysis and walking velocity demonstrated an improvement after treatment in the gastrocnemius-injected group (P < 0.001). In conclusion, intramuscular botulinum toxin type A administration may be effective in children with cerebral palsy, especially at week 4 and when injected in gastrocnemius.
authors.affiliation: SSK Tepecik Teaching Hospital, Clinics of Pediatrics, Izmir, Turkey.
authors.forename: Berrak
authors.initials: B
authors.lastname: Sarioglu
authors.forename: Gul
authors.initials: G
authors.lastname: Serdaroglu
authors.forename: Sarenur
authors.initials: S
authors.lastname: Tutuncuoglu
authors.forename: Esra A
authors.initials: EA
authors.lastname: Ozer
mesh_terms: D000293:Adolescent; D019274:Botulinum Toxins, Type A / Q000494:pharmacology / Q000627:therapeutic use*; D002547:Cerebral Palsy / Q000188:drug therapy / Q000503:physiopathology; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D009128:Muscle Spasticity / Q000188:drug therapy* / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D018709:Statistics, Nonparametric; D014743:Videotape Recording / Q000379:methods
chemical_list: D019274:Botulinum Toxins, Type A