title: [Radiation-induced cardiac disease].
abstract: Radiation-induced effects may damage various cardiac structures chronically and cause heart valve dysfunction as well as occlusive lesions of coronary and other arteries exposed to radiation. A 72-year-old woman with a history of radiation treatment after breast cancer was admitted 25 years later with symptoms of tachycardia and acute dyspnea. We found valvular thickening, medium to severe valvular dysfunction and high grade occlusive coronary artery disease in proximal portions. The left subclavian artery also was affected. Surgical treatment was required immediately. Long-term follow-up cardiac evaluation even in asymptomatic patients is mandatory to uncover cardiac injuries by radiation. To lower the risk and maximize the benefit, early intervention by valvular replacement and myocardial revascularization is indicated. Restrictive myopathy and chronic pericarditis increase risk and have to be clarified. Diagnosis in these radiation exposed patients can be made by typical findings. Echocardiography is of eminent relevancy.
authors.affiliation: I. Medizinische Klinik, Diakoniekrankenhaus Rotenburg, 27342 Rotenburg, Germany. Andresen@diako-online.de
authors.forename: H
authors.initials: H
authors.lastname: Andresen
authors.forename: N
authors.initials: N
authors.lastname: Kaag
authors.forename: A
authors.initials: A
authors.lastname: Meinhardt
authors.forename: J
authors.initials: J
authors.lastname: Potratz
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D023921:Coronary Stenosis / Q000175:diagnosis* / Q000601:surgery; D003331:Coronary Vessels / Q000528:radiation effects*; D004452:Echocardiography; D004699:Endocardium / Q000528:radiation effects*; D004719:Endomyocardial Fibrosis / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006349:Heart Valve Diseases / Q000175:diagnosis* / Q000601:surgery; D006351:Heart Valves / Q000528:radiation effects*; D006801:Humans; D008408:Mastectomy; D011832:Radiation Injuries / Q000175:diagnosis* / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D014261:Tricuspid Valve / Q000528:radiation effects / Q000601:surgery