title: Cell migration: integrating signals from front to back.
abstract: Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mental retardation, atherosclerosis, and arthritis. The migrating cell is highly polarized with complex regulatory pathways that spatially and temporally integrate its component processes. This review describes the mechanisms underlying the major steps of migration and the signaling pathways that regulate them, and outlines recent advances investigating the nature of polarity in migrating cells and the pathways that establish it.
authors.affiliation: Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK.
authors.forename: Anne J
authors.initials: AJ
authors.lastname: Ridley
authors.forename: Martin A
authors.initials: MA
authors.lastname: Schwartz
authors.forename: Keith
authors.initials: K
authors.lastname: Burridge
authors.forename: Richard A
authors.initials: RA
authors.lastname: Firtel
authors.forename: Mark H
authors.initials: MH
authors.lastname: Ginsberg
authors.forename: Gary
authors.initials: G
authors.lastname: Borisy
authors.forename: J Thomas
authors.initials: JT
authors.lastname: Parsons
authors.forename: Alan Rick
authors.initials: AR
authors.lastname: Horwitz
mesh_terms: D008841:Actin Cytoskeleton / Q000502:physiology; D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D016764:Cell Polarity; D006801:Humans; D016023:Integrins / Q000502:physiology; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism; D011554:Pseudopodia / Q000502:physiology; D015398:Signal Transduction
chemical_list: D016023:Integrins; D011506:Proteins