The activation of bovine plasminogen by PauA is not required for virulence of Streptococcus uberis.
A mutant of Streptococcus uberis carrying a single copy of ISS1 within pauA was unable to activate bovine plasminogen. Contrary to a hypothesis postulated previously, this mutation did not alter the ability of the bacterium to grow in milk or to infect the lactating bovine mammary gland.
Ward
Philip N
PN
Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berks, United Kingdom RG20 7NN.
Field
Terence R
TR
Rapier
Christopher D
CD
Leigh
James A
JA
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology / Q000503:physiopathology; D005260:Female; D007774:Lactation; D008321:Mammary Glands, Animal / Q000382:microbiology / Q000503:physiopathology*; D008414:Mastitis, Bovine / Q000382:microbiology / Q000503:physiopathology*; D010958:Plasminogen / Q000378:metabolism*; D010960:Plasminogen Activators / Q000235:genetics / Q000378:metabolism*; D013291:Streptococcus / Q000472:pathogenicity*; D014774:Virulence
D001426:Bacterial Proteins; C121687:PauA protein, Streptococcus uberis; D010958:Plasminogen; D010960:Plasminogen Activators