New minor taxane derivatives from the needles of Taxus canadensis.
Seven minor taxane derivatives were isolated for the first time from the needles of Taxus canadensis. Four of these natural taxanes are O-glycosylated (1-4), with 4 being the only reported taxane with a glucose on ring C, and two have a dimethylamino-C-5 side chain (5 and 6). An unusual double bond at C-5(6) has been identified in taxane 7.
Shi
Qing-Wen
QW
Human Health Research Center, INRS-Institut Armand-Frappier, Université du Québec, 531 Boulevard des Prairies, Laval, Québec, Canada H7V 1B7.
Sauriol
Françoise
F
Mamer
Orval
O
Zamir
Lolita O
LO
D001952:Bridged-Ring Compounds / Q000737:chemistry / Q000302:isolation & purification*; D002170:Canada; D002851:Chromatography, High Pressure Liquid; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D043823:Taxoids; D020946:Taxus / Q000737:chemistry*
D001952:Bridged-Ring Compounds; D043823:Taxoids; C080625:taxane