(S)-(+)-N-acetylphenylglycineboronic acid: a chiral derivatizing agent for Ee determination of 1,2-diols.
A new chiral derivatizing agent for ee determination of 1,2-diols via (1)H NMR is described. (S)-(+)-N-acetylphenylglycineboronic acid (1) is synthesized in enantiomerically pure form; its reaction with chiral diols quantitatively yields cyclic boronic esters 5a-g. The latter show a remarkably high diastereodifferentiation of proton NMR signals useful for de determination. [reaction: see text]
Caselli
Emilia
E
Università di Modena e Reggio Emilia, via Campi 183, 41100 Modena, Italy.
Danieli
Chiara
C
Morandi
Stefania
S
Bonfiglio
Beatrice
B
Forni
Arrigo
A
Prati
Fabio
F