New cytotoxic sesterterpenoids and norsesterterpenoids from two sponges of the genus Sarcotragus.
New norsesterterpenoids (3 and 4), a sesterterpenoid (6), pyrroloterpenoids (7-10), and a stereoisomer of kurospongin (5) were isolated, along with known furanosesterterpenes (11-15), from two marine sponges of the genus Sarcotragus. The gross structures were established on the basis of NMR and MS analysis. The stereochemistry was defined by combined use of NMR and CD spectroscopy. The compounds were evaluated for cytotoxicity against five human tumor cell lines and were found to exhibit marginal to moderate activity.
Liu
Yonghong
Y
College of Pharmacy, Pusan National University, Busan 609-735, Korea.
Mansoor
Tayyab A
TA
Hong
Jongki
J
Lee
Chong-O
CO
Sim
Chung Ja
CJ
Im
Kwang Sik
KS
Kim
Nam Deuk
ND
Jung
Jee H
JH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016543:Central Nervous System Neoplasms; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007723:Korea; D008175:Lung Neoplasms; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010051:Ovarian Neoplasms; D011161:Porifera / Q000737:chemistry*; D012878:Skin Neoplasms; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D013729:Terpenes