[Adsorbent effect of activated carbon on small molecular uremic toxin and its influence factors].
OBJECTIVE
To analyze the adsorbent effect of activated carbon on uremic toxin and its influence factors.


METHODS
Uremic toxins (urea, creatinine and uric acid) were dissolved in the distilled water to obtain uremic toxic solution. Activated carbon was added to the solution, and the concentrations of uremic toxins were measured at different time spots. To determine the influence factors, some possible related materials, such as bile, amino acid, Ringer's, solution of glucose, HCl or NaOH respectively were added simultaneously.


RESULTS
The concentrations of toxins in uremic toxic solution decreased 5 min after adding the activated carbon. The concentration of urea was the lowest at 30 min, but it increased after 50 min; while the concentrations of creatinine and uric acid reached the lowest level from 10 to 30 min after adding the activated carbon, and maintained at the same level after that. The bile, amino acid, electrolyte, glucose and pH value did not influence the adsorption of uric acid significantly, but they influenced the adsorption of urea and creatinine. Bile and amino acid influenced the concentration of urea remarkably, following glucose, NaOH and HCl. The effect of pH 2.0 solution on the creatinine concentration was the most significant, following glucose.


CONCLUSIONS
Activated carbon has adsorptive effect on uremic toxins, but its adsorptive effect decreases as time goes on. Bile, glucose, amino acid, NaOH and HCl can affect the adsorptive effect of activated carbon on uremic toxins to some extent.
Yang
Bo
B
Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Jiang
Yun-sheng
YS
Li
Jun
J
D000327:Adsorption; D002606:Charcoal / Q000737:chemistry; D003404:Creatinine / Q000032:analysis / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D012996:Solutions; D014508:Urea / Q000032:analysis / Q000737:chemistry; D014511:Uremia; D014527:Uric Acid / Q000032:analysis / Q000737:chemistry
D012996:Solutions; D002606:Charcoal; D014527:Uric Acid; D014508:Urea; D003404:Creatinine