[The electro-physiological change of guinea pig cochlea caused by intracochlear perfusion of sodium salicylate].
OBJECTIVE
To investigate the way how sodium salicylate affects cochlear function and discuss its possible mechanism.


METHODS
Sodium salicylate was perfused through guinea pig cochlea. The thresholds and input-output (I/O) functions of compound action potential (CAP) and summating potential (SP) were monitored during the perfusion.


RESULTS
Sodium salicylate caused a significant change of CAP and SP threshold as well as I/O curve. The relationship between CAP and SP threshold change at 10 kHz during perfusion with 10 mmol/L salicylate tends to be 1:1.


CONCLUSIONS
Outer hair cells are most likely to be the sites of action of sodium salicylate and this action on the outer hair cell active process might lead to its ototoxicity.
Zhang
Siyi
S
Department of Otolaryngology, Guangdong Provincial People's Hospital, Guangzhou 510100.
Robertson
Don
D
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003051:Cochlea / Q000187:drug effects / Q000502:physiology*; D003055:Cochlear Microphonic Potentials / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D018072:Hair Cells, Auditory, Outer / Q000187:drug effects / Q000502:physiology; D008297:Male; D010477:Perfusion; D012980:Sodium Salicylate / Q000633:toxicity*
D012980:Sodium Salicylate