title: No replication of the association between the Nicastrin gene and familial early-onset Alzheimer's disease.
abstract: Polymorphisms in the Nicastrin (NCSTN) gene have recently been associated with familial early-onset Alzheimer's disease (AD). The authors genotyped four NCTSN polymorphisms in a large cohort of 489 AD cases (including 158 sporadic early-onset AD cases and 95 familial early-onset AD cases) and 386 controls but failed to replicate the association between NCSTN haplotype B and AD.
authors.affiliation: Aventis Pharma, Evry Genetics Center and Neurodegenerative disease group, Paris Research Center, 13 Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Cousin
authors.forename: Didier
authors.initials: D
authors.lastname: Hannequin
authors.forename: Sandrine
authors.initials: S
authors.lastname: Macé
authors.forename: Bruno
authors.initials: B
authors.lastname: Dubois
authors.forename: Sylvain
authors.initials: S
authors.lastname: Ricard
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Génin
authors.forename: Christophe
authors.initials: C
authors.lastname: Brun
authors.forename: Céline
authors.initials: C
authors.lastname: Chansac
authors.forename: Laurent
authors.initials: L
authors.lastname: Pradier
authors.forename: Thierry
authors.initials: T
authors.lastname: Frebourg
authors.forename: Alexis
authors.initials: A
authors.lastname: Brice
authors.forename: Dominique
authors.initials: D
authors.lastname: Campion
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Deleuze
mesh_terms: D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D053829:Amyloid Precursor Protein Secretases; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D005602:France; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D008562:Membrane Glycoproteins; C413604:nicastrin protein; D053829:Amyloid Precursor Protein Secretases