Dietary components may prevent mutation-related diseases in humans.
Since it is not always possible to reduce human exposure to mutagens, attempts have been directed to identify potential antimutagens and anticarcinogens for use in protecting the population against environmental disease. The purpose of this paper is to provide the reader with information about the antimutagenic and anticarcinogenic potentials of some dietary constituents and foods widely consumed in Brazil, and to reinforce diet as a key factor in determining genomic stability and preventing human diseases. In this report, we have summarized data that show interactive effects between some dietary components and specific chemical mutagens or carcinogens using in vitro and in vivo short- or medium-term assays. The summary indicates that certain dietary compounds may be useful agents for disease prevention.
Ribeiro
Lúcia Regina
LR
Programa de Pós-Graduação em Patologia, Faculdade de Medicina de Botucatu-UNESP, 18618-000 Botucatu, SP, Brazil.
Salvadori
Daisy Maria Favero
DM
D000363:Agaricales; D016588:Anticarcinogenic Agents; D016587:Antimutagenic Agents; D003110:Colonic Neoplasms / Q000517:prevention & control; D004032:Diet; D005505:Food Coloring Agents; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000517:prevention & control*; D006801:Humans; D027805:Phaseolus; D011429:Propolis / Q000627:therapeutic use
D016588:Anticarcinogenic Agents; D016587:Antimutagenic Agents; D005505:Food Coloring Agents; D011429:Propolis