Coronary artery disease and the MEF2A transcription factor.
Coronary artery disease (CAD) that results from lesions of the vascular wall is a major cause of myocardial infarction (MI) and stroke. A human pedigree with a predisposition to CAD and MI has been shown to harbor a mutation in the MEF2A transcription factor. These findings reveal a new function for this regulator of cardiovascular development and raise intriguing questions about the underlying mechanisms of CAD.
Olson
Eric N
EN
Department of Molecular Biology, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA. eric.olson@utsouthwestern.edu
D003324:Coronary Artery Disease / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000502:physiology; D006801:Humans; D026161:MADS Domain Proteins; D064326:MEF2 Transcription Factors; D009154:Mutation; D018006:Myogenic Regulatory Factors; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology
D004268:DNA-Binding Proteins; D026161:MADS Domain Proteins; D064326:MEF2 Transcription Factors; C578035:MEF2A protein, human; D018006:Myogenic Regulatory Factors; D014157:Transcription Factors