New and emerging data from clinical trials of statins.
Recent clinical trials of statins have clearly demonstrated the benefit of statin therapy in preventing both coronary and cerebral vascular events. These benefits have been demonstrated to be present without reference to older age, sex, or comorbid conditions, including hypertension and diabetes. Future trials will test the value of more aggressive low-density lipoprotein cholesterol lowering, the value of immediate statin intervention during acute coronary syndromes, the role of cholesterol lowering with or without angioplasty, and the role of cholesterol lowering in stroke prevention.
LaRosa
John C
JC
State University of New York Downstate Medical Center, 450 Clarkson Avenue, Box 1, Brooklyn, NY 11203-2098, USA. jclarosa@downstate.edu
D008078:Cholesterol, LDL / Q000097:blood; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000517:prevention & control*; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D020521:Stroke / Q000517:prevention & control*
D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents