title: Roc, a Ras/GTPase domain in complex proteins.
abstract: We identified a novel group of the Ras/GTPase superfamily, termed Roc, that is present as domain in complex proteins together with other domains, including leucine-rich repeats (LRRs), ankyrin repeats, WD40 repeats, kinase domains, RasGEF and RhoGAP domains. Roc is always succeeded by a novel 300-400-amino-acid-long domain, termed COR. Proteins with Roc/COR are present in prokaryotes, Dictyostelium, plants and metazoa.
authors.affiliation: Department of Biochemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
authors.forename: Leonard
authors.initials: L
authors.lastname: Bosgraaf
authors.forename: Peter J M
authors.initials: PJ
authors.lastname: Van Haastert
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004023:Dictyostelium / Q000737:chemistry; D005656:Fungal Proteins / Q000737:chemistry / Q000145:classification; D006801:Humans; D020930:MAP Kinase Kinase Kinases / Q000737:chemistry; D046911:Macromolecular Substances; D008969:Molecular Sequence Data; D010802:Phylogeny; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D018631:ras Proteins / Q000737:chemistry* / Q000145:classification*
chemical_list: D005656:Fungal Proteins; D046911:Macromolecular Substances; D020930:MAP Kinase Kinase Kinases; D018631:ras Proteins