4-(4-alkylpiperazin-1-yl)phenyl group: a novel class of basic side chains for selective estrogen receptor modulators.
In the structure-activity relationships of spiro[indene-1,1'-indane] series, the 4-(4-alkylpiperazin-1-yl)phenyl group was found to be functionally equipotent to the 4-(1-piperidinoethoxy)phenyl group, the most widely used basic side chain in selective estrogen receptor modulators.
Watanabe
Nobuhide
N
Chemistry Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Enoki-cho 33-94, Suita, Osaka 564-0053, Japan. nobuhide-watanabe@dainippon-pharm.co.jp
Nakagawa
Hiroshi
H
Ikeno
Akihisa
A
Minato
Hisao
H
Kohayakawa
Chie
C
Tsuji
Jun-ichi
J
D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D008968:Molecular Conformation; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D011960:Receptors, Estrogen / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014599:Uterus / Q000187:drug effects / Q000502:physiology
D000473:Alkanes; D010879:Piperazines; D011960:Receptors, Estrogen; D002784:Cholesterol