title: Whole blood manganese correlates with high signal intensities on T1-weighted MRI in patients with liver cirrhosis.
abstract: We examined whole blood (MnB), plasma (MnP) and urinary Mn (MnU) concentrations in 33 cirrhotics and 11 healthy controls to clarify: (1) whether, in chronic liver diseases, MnB or MnP reflects pallidal signal intensities in magnetic resonance imaging (MRI); and (2) which factors in chronic liver diseases correlate with pallidal signal intensities in T1-weighted MRI. Increased signal intensity in the pallidum was observed in 27 (81.8%) of 33 patients with liver cirrhosis in T1-weighted MRI. There was a significant correlation between MnB and pallidal index (PI) (gamma = 0.559, P < 0.01) in the patients. However, no significant correlation was observed between MnP and PI (gamma = 0.353, P > 0.05). According to a multiple linear regression, MnB reflected the signal intensities of T1-weighted MRI better than MnP or MnU. Child/Pugh score and total bilirubin level also correlated with PI. However, the hemoglobin level did not correlate with PI significantly.
authors.affiliation: Department of Internal Medicine, Ulsan University Hospital, #290-3 Cheonha-Dong, Dong-Ku, Ulsan 682-060, South Korea.
authors.forename: Neung Hwa
authors.initials: NH
authors.lastname: Park
authors.forename: Ji Kang
authors.initials: JK
authors.lastname: Park
authors.forename: Younghee
authors.initials: Y
authors.lastname: Choi
authors.forename: Cheol-In
authors.initials: CI
authors.lastname: Yoo
authors.forename: Choong Ryeol
authors.initials: CR
authors.lastname: Lee
authors.forename: Hun
authors.initials: H
authors.lastname: Lee
authors.forename: Hyo Kyung
authors.initials: HK
authors.lastname: Kim
authors.forename: Sung-Ryul
authors.initials: SR
authors.lastname: Kim
authors.forename: Tae-Heum
authors.initials: TH
authors.lastname: Jeong
authors.forename: Jungsun
authors.initials: J
authors.lastname: Park
authors.forename: Chung Sik
authors.initials: CS
authors.lastname: Yoon
authors.forename: Yangho
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D005917:Globus Pallidus / Q000378:metabolism; D006801:Humans; D016014:Linear Models; D008103:Liver Cirrhosis / Q000097:blood*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008345:Manganese / Q000097:blood*; D008875:Middle Aged
chemical_list: D008345:Manganese