title: Experimental infection of goats at different stages of pregnancy with caprine herpesvirus 1.
abstract: Three goats from a group of five caprine herpesvirus 1 (CpHV.1) seronegative pregnant goats were inoculated intranasally with a virulent BA.1 strain of CpHV.1. Goat n.1 was infected on day 45 of pregnancy, goat n.2 on day 92 and goat n.3 on day 127. Each of the three goats produced a single foetus 10-60 days after infection. Foetus n.1 was never found and so it could not be examined for virological findings. Goat n.2 delivered at term of gestation and CpHV.1 was detected by PCR and isolated from most of the foetal organs. Foetus n.3 was partially autolysed and the virus was only detected by PCR but not isolated from foetal organs. The results confirm the damaging effect of CpHV.1 infection on pregnancy, the difficulty in diagnosing the CpHV.1 induced abortion, and the importance developing appropriate prophylactic programmes.
authors.affiliation: Faculty of Veterinary Medicine, Department of Health and Animal Welfare, University of Bari, Strada provinciale per Casamassima km 3, Valenzano, 70010, Bari, Italy. m.tempesta@veterinaria.uniba.it
authors.forename: M
authors.initials: M
authors.lastname: Tempesta
authors.forename: M
authors.initials: M
authors.lastname: Camero
authors.forename: R L
authors.initials: RL
authors.lastname: Sciorsci
authors.forename: G
authors.initials: G
authors.lastname: Greco
authors.forename: R
authors.initials: R
authors.lastname: Minoia
authors.forename: V
authors.initials: V
authors.lastname: Martella
authors.forename: A
authors.initials: A
authors.lastname: Pratelli
authors.forename: C
authors.initials: C
authors.lastname: Buonavoglia
mesh_terms: D000034:Abortion, Veterinary / Q000473:pathology / Q000821:virology*; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D005260:Female; D005333:Fetus / Q000473:pathology / Q000821:virology; D015511:Goat Diseases / Q000473:pathology / Q000821:virology*; D006041:Goats; D006566:Herpesviridae Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D008297:Male; D009500:Neutralization Tests / Q000662:veterinary; D016133:Polymerase Chain Reaction / Q000662:veterinary; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000473:pathology / Q000662:veterinary*; D018140:Varicellovirus / Q000235:genetics / Q000254:growth & development*
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral