title: Quick parathormone assay in the surgical management of hyperparathyroidism.
abstract: BACKGROUND
  Among the various new technologies in the field of parathyroid surgery is intraoperative quick parathormone measurements.
  
  
  OBJECTIVE
  To evaluate the contribution of QPTH measurements during parathyroidectomy to the achievement of higher success rates.
  
  
  METHODS
  QPTH assay using Immulite Turbo Intact PTH was measured in 32 patients undergoing parathyroidectomy: 30 for primary and 2 for secondary hyperparathyroidism. QPTH levels were measured at time 0 minutes (before incision) and at 10, 20, and 30 minutes after excision of the hyperfunctioning gland. Only a drop of 60% or more from the 0' level was considered to be a positive result.
  
  
  RESULTS
  The mean QPTH level at time 0' for PHPT patients was 38.12 +/- 25.15 pmol/L (range 9.1-118 pmol/L). At 10 minutes post-excision of the hyperfunctioning gland (or glands), QPTH dropped by a mean of 73.80% to 9.89 +/- 18.78 pmol/L.
  
  
  CONCLUSIONS
  Intraoperative QPTH level measurement is helpful in parathyroid surgery. A drop of 60% or more from 0' level indicates a successful procedure, and further exploration should be avoided.
authors.affiliation: Surgical Division, Assaf Harofeh Medical Center, Zerifin, Israel. ahalevi@asaf.health.gov.il
authors.forename: Ariel
authors.initials: A
authors.lastname: Halevy
authors.forename: Albert
authors.initials: A
authors.lastname: Stepansky
authors.forename: Zvi
authors.initials: Z
authors.lastname: Halpern
authors.forename: Ilan
authors.initials: I
authors.lastname: Wassermann
authors.forename: Zehava
authors.initials: Z
authors.lastname: Chen-Levy
authors.forename: Shlomo
authors.initials: S
authors.lastname: Pytlovich
authors.forename: Ora
authors.initials: O
authors.lastname: Marcus
authors.forename: Anat
authors.initials: A
authors.lastname: Mor
authors.forename: Philip
authors.initials: P
authors.lastname: Hagag
authors.forename: Tifha
authors.initials: T
authors.lastname: Horne
authors.forename: Semione
authors.initials: S
authors.lastname: Polypodi
authors.forename: Judith
authors.initials: J
authors.lastname: Sandbank
mesh_terms: D000236:Adenoma / Q000150:complications / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002828:Choristoma / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D006965:Hyperplasia / Q000150:complications / Q000473:pathology; D007430:Intraoperative Care / Q000379:methods; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000000981:diagnostic imaging / Q000601:surgery; D010043:Outcome and Process Assessment, Health Care; D010280:Parathyroid Glands / Q000000981:diagnostic imaging / Q000601:surgery; D010281:Parathyroid Hormone / Q000097:blood*; D010282:Parathyroid Neoplasms / Q000150:complications / Q000473:pathology; D011300:Preoperative Care / Q000379:methods; D013965:Thyroidectomy; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D010281:Parathyroid Hormone