title: Stable prediction of mood and anxiety disorders based on behavioral and emotional problems in childhood: a 14-year follow-up during childhood, adolescence, and young adulthood.
abstract: OBJECTIVE
  The goal of this study was to predict the onset of mood and anxiety disorders from parent-reported emotional and behavioral problems in childhood across a 14-year period from childhood into young adulthood.
  
  
  METHODS
  In 1983, parent reports of behavioral and emotional problems were obtained with the Child Behavior Checklist for children and adolescents 4-16 years of age from the Dutch general population. At follow-up 14 years later, lifetime mood and anxiety diagnoses were obtained by a standardized DSM-IV interview for 1,580 subjects. Cox proportional hazards models were used to predict the incidence of mood and anxiety disorders from childhood problems and demographic covariates.
  
  
  RESULTS
  Mood disorders were significantly predicted by high scores on the anxious/depressed scale and on the internalizing composite (withdrawn, somatic complaints, and anxious/depressed). Anxiety disorders were significantly predicted by the social problems scale and the externalizing composite (delinquent behavior and aggressive behavior). Anxiety disorders predominantly started in childhood and early adolescence, whereas the incidence of mood disorders increased sharply in adolescence and young adulthood.
  
  
  CONCLUSIONS
  These results suggest different developmental pathways for mood and anxiety disorders. The predictions based on problem behavior remained stable during the 14-year period across adolescence and young adulthood. The results therefore underline the importance of early intervention and prevention of behavioral and emotional problems in childhood.
authors.affiliation: Department of Child and Adolescent Psychiatry, Sophia Children's Hospital, Erasmus Medical Center, Dr. Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands.
authors.forename: Sabine J
authors.initials: SJ
authors.lastname: Roza
authors.forename: Marijke B
authors.initials: MB
authors.lastname: Hofstra
authors.forename: Jan
authors.initials: J
authors.lastname: van der Ende
authors.forename: Frank C
authors.initials: FC
authors.lastname: Verhulst
mesh_terms: D000293:Adolescent; D000328:Adult; D000342:Affective Symptoms / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D000374:Aggression / Q000523:psychology; D001008:Anxiety Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D002648:Child; D002653:Child Behavior Disorders / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D002675:Child, Preschool; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003710:Demography; D003866:Depressive Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007389:Internal-External Control; D007604:Juvenile Delinquency / Q000523:psychology; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D010552:Personality Assessment / Q000706:statistics & numerical data*; D016016:Proportional Hazards Models; D011594:Psychometrics / Q000706:statistics & numerical data; D015203:Reproducibility of Results