Olefin metathesis in glycobiology: new routes towards diverse neoglycoconjugates.
This report provides a historical overview of the implementation of olefin metathesis in carbohydrate chemistry, with the emphasis on the construction of neoglycoconjugates. The current state-of-the-art in catalyst design allows the preparation of carbohydrate-containing molecules with great structural and functional diversity. Recent examples of complex neoglycoconjugates, including glycopolymers, glycoclusters, glycopeptide and glycolipid analogues are highlighted. Finally, future perspectives in the scope of olefin metathesis mediated neoglycoconjugate synthesis are discussed.
Leeuwenburgh
Michiel A
MA
Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300 RA, Leiden, The Netherlands.
van der Marel
Gijsbert A
GA
Overkleeft
Herman S
HS
D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D001669:Biochemical Phenomena; D001671:Biochemistry; D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000138:chemical synthesis; D006001:Glycoconjugates / Q000138:chemical synthesis*; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D009942:Organometallic Compounds / Q000737:chemistry
D000475:Alkenes; D002241:Carbohydrates; D006001:Glycoconjugates; D009942:Organometallic Compounds