title: Individual aging and mortality rate: how are they related?
abstract: Many researchers working in the area of aging and longevity base their conclusions on the behavior of empirical age trajectories of mortality rates. In such analyses, changes in the slope of the logarithm of the mortality curve are often associated with changes in the rate of individual aging. We show that such interpretation may be incorrect: the changes in the slope of this curve do not necessarily correspond to the changes in the rate of individual aging. We use three models of mortality and aging to illustrate this statement. The first one is based on the idea of frailty. We show that changes in frailty distribution alone may be responsible for changes in the slope. The second model exploits the idea of saving lives. It evaluates changes in mortality rate after elimination of lethal stressful events. The third model uses the idea of Strehler and Mildvan (1960). It shows that changes in the rate of individual aging may take place without changes in the slope of the logarithm of the mortality curve.
authors.affiliation: Max Planck Institute for Demographic Research, Rostock, Germany.
authors.forename: Anatoli I
authors.initials: AI
authors.lastname: Yashin
authors.forename: Svetlana V
authors.initials: SV
authors.lastname: Ukraintseva
authors.forename: Serge I
authors.initials: SI
authors.lastname: Boiko
authors.forename: Konstantin G
authors.initials: KG
authors.lastname: Arbeev
mesh_terms: D000375:Aging / Q000502:physiology*; D006801:Humans; D007206:Individuality; D008017:Life Expectancy; D008954:Models, Biological; D015233:Models, Statistical; D011157:Population Dynamics; D012044:Regression Analysis; D013223:Statistics as Topic; D016019:Survival Analysis; D015996:Survival Rate; D013548:Sweden / Q000453:epidemiology