[Cortical alpha-2a adrenoreceptors involved in the inhibitory control of motor activity in neonatal rats].
Involvement of alpha 2A-adrenoceptors in control of motor activity in neonatal rats was investigated using intrabrain injections of antisense deoxyoligonucleotide targeting mRNA of these receptors. Antisense-induced decrease in the receptor expression in the brain accompanied by an augmentation of animal's motor activity, which was evaluated as a number of paddling movements with the right forepaw. This antisense effect was stimulatory and was not related to somatic growth and maturation of reflexes in the animals. The antisensetreated pups differed from controls neither in body weight nor the latency of righting reflex. The data suggest that alpha 2A-adrenoceptors are involved in inhibitory control of motor activity of rat pups from the first day of life.
Shishkina
G T
GT
Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk.
Kalinina
T S
TS
Masnavieva
L B
LB
Dygalo
N N
NN
D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000502:physiology*; D008124:Locomotion / Q000502:physiology*; D009044:Motor Cortex / Q000378:metabolism*; D009433:Neural Inhibition / Q000502:physiology*; D016372:RNA, Antisense / Q000008:administration & dosage / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics / Q000378:metabolism*; D012018:Reflex / Q000502:physiology; D020133:Reverse Transcriptase Polymerase Chain Reaction
D016372:RNA, Antisense; D012333:RNA, Messenger; D018341:Receptors, Adrenergic, alpha-2