title: Mitochondrial complex II is essential for hypoxia-induced ROS generation and vasoconstriction in the pulmonary vasculature.
abstract: Hypoxia induces an increase in the ROS generation by cells of small intrapulmonary vessels. Based on our results we suppose that this is caused by a switch in the catalytic activity of mitochondrial complex II from succinate dehydrogenase to fumarate reductase. Functional complex II is also necessary for hypoxic pulmonary vasoconstriction.
authors.affiliation: Institute for Anatomy and Cell Biology, Justus-Liebig-University, 35385 Giessen, Germany.
authors.forename: Renate
authors.initials: R
authors.lastname: Paddenberg
authors.forename: Anna
authors.initials: A
authors.lastname: Goldenberg
authors.forename: Petra
authors.initials: P
authors.lastname: Faulhammer
authors.forename: Ruediger C
authors.initials: RC
authors.lastname: Braun-Dullaeus
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kummer
mesh_terms: D000818:Animals; D042963:Electron Transport Complex II / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D066298:In Vitro Techniques; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D009574:Nitro Compounds; D011422:Propionates / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013804:Thenoyltrifluoroacetone / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology
chemical_list: D009574:Nitro Compounds; D011422:Propionates; D017382:Reactive Oxygen Species; D013804:Thenoyltrifluoroacetone; D042963:Electron Transport Complex II; D013385:Succinate Dehydrogenase; C015392:3-nitropropionic acid