title: Neurobehavioral correlates of impulsivity: evidence of prefrontal involvement.
abstract: Impulsivity is associated with the functioning of prefrontal-subcortical circuits particularly, the orbitofrontal circuit, which is shown in neuro-imaging studies of neurological and psychological disorders. Objective behavioral measures, such as go/no-go, antisaccades, and delayed alternation, have demonstrated sensitivity to prefrontal function. This study examined the relationship between orbitofrontal-sensitive measures and impulsivity in healthy adults, as measured by the Barratt Impulsiveness Scale-11 (BIS). Go/no-go and antisaccades correlated positively and delayed alternations correlated negatively with BIS subscales, even after controlling for demographic influences. The results add to the validity of the BIS and support a role for prefrontal cortex in impulse control.
authors.affiliation: Division of Social and Behavioral Sciences, Richard Stockton College of New Jersey, Pomona, New Jersey 08240-0195, USA. marcello.spinella@stockton.edu
authors.forename: Marcello
authors.initials: M
authors.lastname: Spinella
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001288:Attention; D005260:Female; D006801:Humans; D007175:Impulsive Behavior; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D017397:Prefrontal Cortex / Q000502:physiology*; D011594:Psychometrics; D015203:Reproducibility of Results; D012438:Saccades / Q000502:physiology; D013223:Statistics as Topic