[AT1 receptor autoantibodies and essential hypertension].
OBJECTIVE
To observe the relationship between AT1 receptor autoantibodies and clinical features in essential hypertension, and to compare the therapeutic effect of losartan between the positive and the negative group.


METHODS
Clinical data were collected in patients with essential hypertension (n = 123). AT1 receptor autoantibodies were checked. Twenty-four patients from either AT1-positive or AT1-negative group were treated with losartan for 12 weeks.


RESULTS
The average age in the positive group was significantly higher than that of the negative one (P = 0.023). Logistic regression analysis indicated that age was an independant risk factor of AT1 receptor autoantibody. Antihypertensive efficiency of losartan showed no obvious difference between the two groups.


CONCLUSIONS
Positive response of AT1 receptor autoantibody is related only to age. Anti-hypertensive therapy with losartan in the positive group shows no advantage over the negative one, indicating that AT1 receptor autoantibodies possibly have no vascular activity in vivo.
Liu
Hong
H
Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Yang
Yu
Y
Chen
Long-long
LL
D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000276:immunology; D019808:Losartan / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D044140:Receptor, Angiotensin, Type 1 / Q000276:immunology*
D000959:Antihypertensive Agents; D001323:Autoantibodies; D044140:Receptor, Angiotensin, Type 1; D019808:Losartan