title: The linear process of somatic evolution.
abstract: Cancer is the consequence of an unwanted evolutionary process. Cells receive mutations that alter their phenotype. Especially dangerous are those mutations that increase the net reproductive rate of cells, thereby leading to neoplasia and later to cancer. The standard models of evolutionary dynamics consider well mixed populations of individuals in symmetric positions. Here we introduce a spatially explicit, asymmetric stochastic process that captures the essential architecture of evolutionary dynamics operating within tissues of multicellular organisms. The "linear process" has the property of cancelling out selective differences among cells yet retaining the protective function of apoptosis. This design can slow down the rate of somatic evolution dramatically and therefore delay the onset of cancer.
authors.affiliation: Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA. martin_nowak@harcard.edu
authors.forename: Martin A
authors.initials: MA
authors.lastname: Nowak
authors.forename: Franziska
authors.initials: F
authors.lastname: Michor
authors.forename: Yoh
authors.initials: Y
authors.lastname: Iwasa
mesh_terms: D000818:Animals; D017209:Apoptosis; D005075:Biological Evolution; D016147:Genes, Tumor Suppressor; D006801:Humans; D008962:Models, Theoretical; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D010641:Phenotype