The human leukocyte antigen genotype has a modest effect on the insulin gene polymorphism-associated susceptibility to type 1 diabetes in the Finnish population.
In addition to the known human leukocyte antigen (HLA)-associated risk, polymorphisms of insulin gene region show association with type 1 diabetes. We analyzed possible interactions between the HLA class II genotypes and -2221 MspI (insulin) INS gene polymorphism in Finnish population, using a series of 1331 diabetic children and 2222 healthy newborns. C/C genotype was increased among diabetic children compared to the controls (83.2 vs 70.1%). This genotype was slightly more common in diabetic children with low or moderate HLA-associated risk than in those with high risk, but INS gene effect was clear in all major HLA-risk genotypes and, thus, can be used as an additional risk prediction marker, irrespective of HLA genotypes.
Laine
A P
AP
JDRF Centre for Prevention of Type 1 Diabetes, Department of Virology, University of Turku, Turku, Finland. aplaine@utu.fi
Hermann
R
R
Knip
M
M
Simell
O
O
Akerblom
H K
HK
Ilonen
J
J
D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005387:Finland; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007328:Insulin / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
D006680:HLA Antigens; D007328:Insulin