title: Cross-couplings of unactivated secondary alkyl halides: room-temperature nickel-catalyzed Negishi reactions of alkyl bromides and iodides.
abstract: The development of a nickel- or palladium-catalyzed method for cross-coupling unactivated secondary alkyl halides has been a long-standing challenge in synthetic chemistry. This communication describes a simple catalyst system-Ni(cod)2/s-Bu-Pybox-that achieves room-temperature Negishi reactions of an array of functionalized primary and secondary alkyl bromides and iodides.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Jianrong Steve
authors.initials: JS
authors.lastname: Zhou
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Fu
mesh_terms: D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000138:chemical synthesis / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry; D013696:Temperature
chemical_list: D006842:Hydrocarbons, Brominated; D006847:Hydrocarbons, Iodinated; D009942:Organometallic Compounds; D010165:Palladium; D009532:Nickel