title: Neuroimaging correlates of dementia rating scale performance at baseline and 12-month follow-up among patients with vascular dementia.
abstract: The authors previously reported that subcortical hyperintensity (SH) and whole-brain volume (WBV) each covary with different subscale scores of the Mattis Dementia Rating Scale (MDRS) among vascular dementia (VaD) patients. The present longitudinal analysis examined these relationships for change. The authors found that SH volume increased and WBV decreased significantly over 12 months. At baseline, SH volume accounted for significant variance in MDRS total score and every subscale score, except Memory. WBV was unrelated to any MDRS measure. After 12 months, SH volume was related only to the Construction subscale score, whereas WBV accounted for the majority of variance in Attention and Memory subscale performance. These findings indicate that although SH volume increases with disease progression, the relative impact of SH volume on cognitive status decreases among patients with advanced VaD.
authors.affiliation: Brown University Medical School, Miriam Hospital, Providence, RI 20903, USA. lawrence_sweet@brown.edu
authors.forename: Lawrence H
authors.initials: LH
authors.lastname: Sweet
authors.forename: Robert H
authors.initials: RH
authors.lastname: Paul
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Cohen
authors.forename: David
authors.initials: D
authors.lastname: Moser
authors.forename: Brian R
authors.initials: BR
authors.lastname: Ott
authors.forename: Norman
authors.initials: N
authors.lastname: Gordon
authors.forename: Jeff N
authors.initials: JN
authors.lastname: Browndyke
authors.forename: Pari
authors.initials: P
authors.lastname: Shah
authors.forename: Kelly D
authors.initials: KD
authors.lastname: Garrett
mesh_terms: D000368:Aged; D001479:Basal Ganglia / Q000473:pathology; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000175:diagnosis; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use*; D015140:Dementia, Vascular / Q000175:diagnosis* / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013788:Thalamus / Q000473:pathology
chemical_list: D018697:Nootropic Agents; D003566:Cytidine Diphosphate Choline