title: Spontaneous adrenal haemorrhage as a manifestation of isolated relapse of non-Hodgkin's lymphoma.
abstract: Retroperitoneal haemorrhage due to metastatic disease is a rare event not previously reported in lymphomas. We describe a 36-year-old woman diagnosed with diffuse large B cell lymphoma (DLBCL) of bone marrow, liver and spleen presenting in the leukaemic phase. The patient attained complete remission after 'ALL-like' chemotherapy (cyclophosphamide, vincristine, adriamycin, dexamethasone); 22 months later, she developed an isolated central nervous system (CNS) relapse which was successfully managed with a combination of chemotherapy and CNS irradiation. Six months later, she was rehospitalized because of abdominal pain; an MRI revealed a large haemorrhagic mass in the left adrenal. Surgical removal of the lesion confirmed an adrenal relapse of the primary DLBCL.
authors.affiliation: BMT Unit, Haematology Department, G. Papanicolaou General Hospital, Thessaloniki, Greece.
authors.forename: Charalambos
authors.initials: C
authors.lastname: Kartsios
authors.forename: Panayotis
authors.initials: P
authors.lastname: Kaloyannidis
authors.forename: Evangelia
authors.initials: E
authors.lastname: Yannaki
authors.forename: Photios
authors.initials: P
authors.lastname: Iordanidis
authors.forename: Vassilios
authors.initials: V
authors.lastname: Penopoulos
authors.forename: Ioanna
authors.initials: I
authors.lastname: Sakellari
authors.forename: Achilles
authors.initials: A
authors.lastname: Anagnostopoulos
mesh_terms: D000307:Adrenal Gland Diseases / Q000150:complications / Q000175:diagnosis*; D000328:Adult; D005260:Female; D006470:Hemorrhage / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D012008:Recurrence