title: New cytotoxic sesterterpenoids and norsesterterpenoids from two sponges of the genus Sarcotragus.
abstract: New norsesterterpenoids (3 and 4), a sesterterpenoid (6), pyrroloterpenoids (7-10), and a stereoisomer of kurospongin (5) were isolated, along with known furanosesterterpenes (11-15), from two marine sponges of the genus Sarcotragus. The gross structures were established on the basis of NMR and MS analysis. The stereochemistry was defined by combined use of NMR and CD spectroscopy. The compounds were evaluated for cytotoxicity against five human tumor cell lines and were found to exhibit marginal to moderate activity.
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Korea.
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Liu
authors.forename: Tayyab A
authors.initials: TA
authors.lastname: Mansoor
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Chong-O
authors.initials: CO
authors.lastname: Lee
authors.forename: Chung Ja
authors.initials: CJ
authors.lastname: Sim
authors.forename: Kwang Sik
authors.initials: KS
authors.lastname: Im
authors.forename: Nam Deuk
authors.initials: ND
authors.lastname: Kim
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016543:Central Nervous System Neoplasms; D003110:Colonic Neoplasms; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D007723:Korea; D008175:Lung Neoplasms; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010051:Ovarian Neoplasms; D011161:Porifera / Q000737:chemistry*; D012878:Skin Neoplasms; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D013729:Terpenes