MoMLV reverse transcriptase regulates its own expression.
A precise ratio of Gag:Gag-Pol expression is required for assembly of infectious retroviral virions. In this issue of Cell, Orlova et al. show that MoMLV reverse transcriptase binds the translation release factor eRF1, and that this interaction promotes translation readthrough to make Gag-Pol.
Bradley
Christina
C
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 20892, Bethesda, MD, USA
Craigie
Robert
R
D000818:Animals; D015685:Fusion Proteins, gag-pol / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D008979:Moloney murine leukemia virus / Q000201:enzymology* / Q000235:genetics / Q000502:physiology; D010454:Peptide Termination Factors / Q000378:metabolism*; D011485:Protein Binding; D014176:Protein Biosynthesis; D012194:RNA-Directed DNA Polymerase / Q000235:genetics / Q000378:metabolism*; D013379:Substrate Specificity; D014771:Virion / Q000737:chemistry / Q000378:metabolism; D014779:Virus Replication
C489003:Etf1 protein, mouse; D015685:Fusion Proteins, gag-pol; D010454:Peptide Termination Factors; D012194:RNA-Directed DNA Polymerase