title: Triterpenoids from Schisandra henryi with cytotoxic effect on leukemia and Hela cells in vitro.
abstract: Four known lanostane triterpenoids, schiprolactone A (1), schisanlactone B (2), nigranoic acid (3) and schisandronic acid (4) were isolated from the stems of Schisandra henryi for the first time. Their structures were characterized by IR, MS and NMR techniques. Compounds 1, 2 and 4 showed moderate cytotoxic activity against Leukemia cells in vitro. Cytotoxic activity of compounds 1-4 showed IC50 of 0.0097, 0.01, 0.097 and 0.0099 micromol/mL respectively toward Leukemia cells and IC50 of 0.097, 0.1, 0.097 and 0.099 micromol/mL toward Hela cells respectively. It is the first report that these compounds possess cytotoxic activity on Leukemia and Hela cells.
authors.affiliation: Department of Chemistry, Yunnan Normal University, Kunming 650092, China. ygchen48@hotmail.com
authors.forename: Ye-Gao
authors.initials: YG
authors.lastname: Chen
authors.forename: Zheng-Cai
authors.initials: ZC
authors.lastname: Wu
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Lv
authors.forename: Shi-Hong
authors.initials: SH
authors.lastname: Gui
authors.forename: Jin
authors.initials: J
authors.lastname: Wen
authors.forename: Xin-Rong
authors.initials: XR
authors.lastname: Liao
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Yuan
authors.forename: Fathi
authors.initials: F
authors.lastname: Halaweish
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006367:HeLa Cells; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000473:pathology*; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D018547:Plant Stems; D032141:Schisandra; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts; D014315:Triterpenes