title: Diterpenoids from the stem barks of Croton robustus.
abstract: Three compounds were isolated from the stem barks of Croton robustus. Their structures were elucidated as trachyloban-19-oic acid, trachyloban-19-ol and poilaneic acid by spectroscopic analysis. Among them, trachyloban-19-ol and methyl trachyloban-19-oate exhibited weak cytotoxic activity against gastric carcinoma and colon carcinoma with ED50 of 9.2, 9.6 and 8.3, 9.1 microg/mL, respectively.
authors.affiliation: Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkom University, Bangkok 10330, Thailand.
authors.forename: Nattaya
authors.initials: N
authors.lastname: Ngamrojnavanich
authors.forename: Sorasaree
authors.initials: S
authors.lastname: Tonsiengsom
authors.forename: Preecha
authors.initials: P
authors.lastname: Lertpratchya
authors.forename: Sophon
authors.initials: S
authors.lastname: Roengsumran
authors.forename: Songchan
authors.initials: S
authors.lastname: Puthong
authors.forename: Amorn
authors.initials: A
authors.lastname: Petsom
mesh_terms: D045744:Cell Line, Tumor; D029802:Croton; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems
chemical_list: D004224:Diterpenes; D010936:Plant Extracts