Carbamazepine, clonazepam and focal reflex proprioceptive seizures.
We studied a 34-year-old man with focal tonic-clonic seizures sometimes elicited by some active postures of the right hand and evolving at times to secondary generalization. Treatment with carbamazepine (CBZ) in combination with parenteral diazepam induced both a dramatic increase of focal reflex proprioceptive seizures and choreoathetoid dyskinesias in the affected hand. CBZ was withdrawn and clonazepam (CZP) given 2 mg daily, with complete relief of seizures and choreoathetoid dyskinesias. CZP had a suppressive effect on seizures for over 15 years, without development of tolerance.
Sechi
GianPietro
G
Department of Neurology, University of Sassari, Neurological Clinic, Viale S. Pietro 10, 07100-Sassari, Italy. gpsechi@ssmain.uniss.it
Corda
Davide
D
Deiana
Giovanni A
GA
Contu
Sabrina
S
Rosati
Giulio
G
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D002998:Clonazepam / Q000627:therapeutic use*; D004829:Epilepsy, Generalized / Q000188:drug therapy / Q000503:physiopathology; D020195:Epilepsy, Reflex / Q000188:drug therapy* / Q000503:physiopathology; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy / Q000503:physiopathology; D006225:Hand / Q000502:physiology; D006801:Humans; D008297:Male; D011187:Posture / Q000502:physiology; D012008:Recurrence; D012640:Seizures / Q000188:drug therapy* / Q000503:physiopathology
D000927:Anticonvulsants; D002220:Carbamazepine; D002998:Clonazepam