[CCR5, a new target of anti-HIV drugs].
CCR5, a membrane protein on cell surface, is a member of the G protein-coupled receptor superfamily and one of the major co-receptors for HIV-1 infection. The roles of CCR5 in HIV-1 infection have been elucidated since 1996. Because of the biological nature of CCR5, it has became a molecular target for the novel drugs against HIV-1. Antagonists for CCR5 could be grouped as following, chemokine derivatives, small molecule non-peptide compounds, monoclonal antibodies and peptides. The latest progress in this field is reviewed in this article.
Han
Yan-xing
YX
Laboratory of Virology, Institute of Medicinal Biotechnology, CAMS and PUMC, Beijing 100050, China. hanyanxing@hotmail.com
Jiang
Jian-dong
JD
D019380:Anti-HIV Agents / Q000494:pharmacology*; D000911:Antibodies, Monoclonal; D065100:CCR5 Receptor Antagonists; D015195:Drug Design; D015658:HIV Infections / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects; D019713:Receptors, CCR5 / Q000187:drug effects*; D019707:Receptors, Chemokine / Q000187:drug effects*
D019380:Anti-HIV Agents; D000911:Antibodies, Monoclonal; D065100:CCR5 Receptor Antagonists; D019713:Receptors, CCR5; D019707:Receptors, Chemokine