title: beta-alanine dipeptides as MC4R agonists.
abstract: beta-Alanine derivative 2 (IC(50)=16 nM) and related compounds were found to be potent MC4R agonists.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, 100 boul. de l'Industrie, Candiac, Quebec, Canada J5R 1J1. rejean.ruel@bms.com
authors.forename: Réjean
authors.initials: R
authors.lastname: Ruel
authors.forename: Timothy F
authors.initials: TF
authors.lastname: Herpin
authors.forename: Lawrence
authors.initials: L
authors.lastname: Iben
authors.forename: Guanglin
authors.initials: G
authors.lastname: Luo
authors.forename: Alain
authors.initials: A
authors.lastname: Martel
authors.forename: Helen
authors.initials: H
authors.lastname: Mason
authors.forename: Gail
authors.initials: G
authors.lastname: Mattson
authors.forename: Brigitte
authors.initials: B
authors.lastname: Poirier
authors.forename: Edward H
authors.initials: EH
authors.lastname: Ruediger
authors.forename: Dan
authors.initials: D
authors.lastname: Shi
authors.forename: Carl
authors.initials: C
authors.lastname: Thibault
authors.forename: Guixue
authors.initials: G
authors.lastname: Yu
authors.forename: Ildiko
authors.initials: I
authors.lastname: Antal Zimanyi
authors.forename: Graham S
authors.initials: GS
authors.lastname: Poindexter
authors.forename: John E
authors.initials: JE
authors.lastname: Macor
mesh_terms: D000818:Animals; D001665:Binding Sites; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D015195:Drug Design; D005247:Feeding Behavior / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D023421:Models, Animal; D008958:Models, Molecular; D044105:Receptor, Melanocortin, Type 4 / Q000819:agonists*; D013329:Structure-Activity Relationship; D015091:beta-Alanine / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D004151:Dipeptides; D044105:Receptor, Melanocortin, Type 4; D015091:beta-Alanine