[The ultradian rhythm of sleep: diverse relations with pituitary and adrenal hormones].
We evaluated the relationship between the ultradian rhythm of sleep and the secretory episodes of pituitary-adrenal hormones. Prolactin (PRL) and TSH exhibited opposite phase relationships with delta waves, PRL increasing and TSH decreasing when delta waves developed. Delta waves never increased together with an increase in cortisol secretion. They oscillated independently from each other throughout the 24 hour period, but when they were present at the same time, they oscillated in opposing phases. Concerning growth hormone (GH), its major peak which occurred shortly after sleep onset in association with the first slow wave sleep episode was blunted during sleep deprivation. However, this blunting was compensated during the day, so that the amount of GH secreted during a 24-hr period was similar whether or not a person had slept during the night. The physiological significance and the clinical implications of the various relationships of the endocrine systems with sleep are poorly known.
Brandenberger
G
G
Institut de Physiologie, Laboratoire des Régulations Physiologiques et des Rythmes Biologiques chez l'Homme, Strasbourg. Brandenberger.Gabrielle@medecine.u-strasbg.fr
D000328:Adult; D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm / Q000502:physiology*; D003700:Delta Rhythm; D006130:Growth Disorders / Q000209:etiology / Q000503:physiopathology; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D007223:Infant; D010913:Pituitary-Adrenal System / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism; D012636:Secretory Rate; D012894:Sleep Stages / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000150:complications / Q000503:physiopathology; D013972:Thyrotropin / Q000378:metabolism
D019382:Human Growth Hormone; D011388:Prolactin; D013972:Thyrotropin; D006854:Hydrocortisone