title: Building a BRIDGE for the integration of heterogeneous data from functional genomics into a platform for systems biology.
abstract: The flood of data acquired from the increasing number of publicly available genomes has led to new demands for bioinformatics software. With the growing amount of information resulting from high throughput experiments new questions arise that often focus on the comparison of genes, genomes, and their expression profiles. Inferring new knowledge by combining different kinds of "post-genomics" data obviously necessitates the development of new approaches that allow the integration of variable data sources into a flexible framework. In this paper, we describe our concept for the integration of heterogeneous data into a platform for systems biology. We have implemented a Bioinformatics Resource for the Integration of heterogeneous Data from Genomic Explorations (BRIDGE) and illustrate the usability of our approach as a platform for systems biology for two sample applications.
authors.affiliation: Center for Genome Research, Bielefeld University, D-33594 Bielefeld, Germany. alexander.goesmann@genetik.uni-bielefeld.de
authors.forename: Alexander
authors.initials: A
authors.lastname: Goesmann
authors.forename: Burkhard
authors.initials: B
authors.lastname: Linke
authors.forename: Oliver
authors.initials: O
authors.lastname: Rupp
authors.forename: Lutz
authors.initials: L
authors.lastname: Krause
authors.forename: Daniela
authors.initials: D
authors.lastname: Bartels
authors.forename: Michael
authors.initials: M
authors.lastname: Dondrup
authors.forename: Alice C
authors.initials: AC
authors.lastname: McHardy
authors.forename: Andreas
authors.initials: A
authors.lastname: Wilke
authors.forename: Alfred
authors.initials: A
authors.lastname: Pühler
authors.forename: Folker
authors.initials: F
authors.lastname: Meyer
mesh_terms: D000465:Algorithms; D003628:Database Management Systems; D030541:Databases, Genetic; D020869:Gene Expression Profiling / Q000379:methods*; D023281:Genomics / Q000379:methods*; D016247:Information Storage and Retrieval / Q000379:methods*; D012984:Software; D012985:Software Design; D018511:Systems Integration; D014584:User-Computer Interface