1-aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents.
A set of novel 1-aryl-6,7-methylenedioxy-3H-quinazolin-4-(thi)ones (3a-f) has been designed and screened as anticonvulsant agents in DBA/2 mice. The new compounds are provided with anticonvulsant properties comparable to those of GYKI 52466. To clarify the mode of action, their affinity for the quinazolinone/2,3-benzodiazepine site of the AMPA receptor complex has been assayed.
Zappalà
Maria
M
Dipartimento Farmaco-Chimico, Università di Messina, viale Annunziata, 98168 Messina, Italy.
Grasso
Silvana
S
Micale
Nicola
N
Zuccalà
Giuseppe
G
Menniti
Frank S
FS
Ferreri
Guido
G
De Sarro
Giovambattista
G
De Micheli
Carlo
C
D000161:Acoustic Stimulation; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001569:Benzodiazepines / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D051379:Mice; D008958:Models, Molecular; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012640:Seizures / Q000209:etiology / Q000517:prevention & control; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D011799:Quinazolines; C061950:GYKI 52466; D001569:Benzodiazepines