Combination therapy of disseminated Fusarium oxysporum infection with terbinafine and amphotericin B.
A case of disseminated infection with Fusarium oxysporum following chemotherapy of acute myelogenous leukemia is reported. Antifungal treatment was successful with a 13-day course of oral terbinafine 250 mg t.i.d. in combination with amphotericin B deoxycholate 1.0-1.5 mg/kg qd and subsequently intravenous liposomal amphotericin B 5 mg/kg qd. Preceding monotherapy with amphotericin B deoxycholate 1.0-1.5 mg/kg qd had not stopped the progression of infection. The combination therapy described here represents a novel approach to the treatment of Fusarium spp. in the immunocompromised host in whom Fusarium spp. are known to cause disseminated infection with high mortality.
Rothe
A
A
Klinik I für Innere Medizin, Universität zu Köln, Joseph-Stelzmann-Str. 9, 50931 Cologne, Germany.
Seibold
M
M
Hoppe
Th
T
Seifert
H
H
Engert
A
A
Caspar
C
C
Karthaus
M
M
Fätkenheuer
G
G
Bethe
U
U
Tintelnot
K
K
Cornely
O A
OA
D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D003881:Dermatomycoses / Q000097:blood / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D004359:Drug Therapy, Combination; D005670:Fusarium; D006801:Humans; D016867:Immunocompromised Host; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000382:microbiology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009281:Naphthalenes / Q000008:administration & dosage* / Q000097:blood; D009503:Neutropenia / Q000188:drug therapy / Q000473:pathology; D000077291:Terbinafine; D016896:Treatment Outcome
D000935:Antifungal Agents; D009281:Naphthalenes; D000666:Amphotericin B; D000077291:Terbinafine