Ocular myasthenia gravis associated with euthyroid ophthalmopathy.
We report a 71-year-old woman with concomitant ocular myasthenia gravis and euthyroid Graves' ophthalmopathy. Unilateral ophthalmoplegia, including ptosis, initially was responsive to edrophonium and corticosteroids, except for diplopia on upward gaze, but refractory swelling of the inferior rectus muscle and proptosis followed. Autoantibodies to acetylcholine and thyrotropin receptors were detected. Her ophthalmopathy abated after orbital irradiation in combination with systemic steroids. There may be an immunological basis for the association of ocular myasthenia gravis with euthyroid Graves' ophthalmopathy.
Kusuhara
Tomohiko
T
Department of Neurology, Fukuoka University School of Medicine, 7-45-1 Nanakuma Johnan-ku, Fukuoka 814-0180, Japan.
Nakajima
Masashi
M
Imamura
Akiko
A
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D005128:Eye Diseases / Q000150:complications* / Q000473:pathology; D005260:Female; D006111:Graves Disease / Q000150:complications* / Q000473:pathology; D006801:Humans; D007116:Immunization, Passive; D008279:Magnetic Resonance Imaging; D008775:Methylprednisolone / Q000627:therapeutic use; D009157:Myasthenia Gravis / Q000150:complications* / Q000473:pathology; D014786:Vision Disorders / Q000209:etiology
D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone