title: Damage to cultivated Japanese pearl oysters by oxidative stress that was related to "mass mortality".
abstract: Increased blood-DNA breakage was observed in diseased pearl oysters. They showed significant formation of 8-hydroxydeoxyguanosine (8-OHdG) and malondialdehyde (MDA), whereas the oysters that had a low mortality rate from the disease had high activity of superoxide dismutase (SOD) and low amounts of 8-OHdG and MDA. These results suggest that radical damage had occurred only in the diseased pearl oysters with the cytolysis of their haemocytes, which was related to the mass mortality of the Japanese pearl oysters.
authors.affiliation: Ehime Prefectural Fisheries Experimental Station., Uwajima, Ehime, Japan.
authors.forename: Yuushi
authors.initials: Y
authors.lastname: Uchimura
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yamashita
authors.forename: Makoto
authors.initials: M
authors.lastname: Kuramoto
authors.forename: Kohji
authors.initials: K
authors.lastname: Ishihara
authors.forename: Manabu
authors.initials: M
authors.lastname: Sugimoto
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Nakajima
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D003643:Death; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000032:analysis; D006434:Hemocytes / Q000502:physiology; D006458:Hemolymph / Q000502:physiology; D007564:Japan; D008315:Malondialdehyde / Q000378:metabolism; D018482:Muscle, Skeletal / Q000502:physiology; D010125:Ostreidae / Q000187:drug effects / Q000502:physiology*; D018384:Oxidative Stress / Q000502:physiology*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D008315:Malondialdehyde; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D013482:Superoxide Dismutase; D003849:Deoxyguanosine