title: Mycobacterial peritonitis in pediatric peritoneal dialysis patients.
abstract: Peritonitis is the most common complication and the leading cause of death in pediatric peritoneal dialysis (PD) patients. According to the most recent data available from the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS), approximately 25% of pediatric PD patients who die succumb to infection. There are no reported cases of Mycobacterium tuberculosis (MTB) or Mycobacterium avium-intracellulare peritonitis in the NAPRTCS registry. With an increasing incidence of MTB worldwide and the impairment of cellular immunity in chronic renal failure patients, it is not surprising that mycobacterium peritonitis can occur in PD patients. We report two pediatric PD patients with mycobacterial peritoneal infection diagnosed over an 11-year period at our institution. One patient presented with a malfunctioning Tenckhoff catheter and again 3 years later with hyponatremia and ascites. The other presented with recurrent culture-negative peritonitis. These cases illustrate the importance of more extensive evaluation of PD complications, to include evaluation for mycobacterium with special media or peritoneal biopsy, in the above clinical settings if the routine work-up is unrevealing.
authors.affiliation: Department of Pediatrics, Division of Pediatric Nephrology, University of California San Diego, 200 W. Arbor Drive MC 0831, San Diego, CA 92103, USA. sferrara@san.rr.com
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Ferrara
authors.forename: Jacques
authors.initials: J
authors.lastname: Lemire
authors.forename: Paul C
authors.initials: PC
authors.lastname: Grimm
authors.forename: Vivian M
authors.initials: VM
authors.lastname: Reznik
authors.forename: Stanley A
authors.initials: SA
authors.lastname: Mendoza
authors.forename: John A
authors.initials: JA
authors.lastname: Leake
authors.forename: Nadine M
authors.initials: NM
authors.lastname: Benador
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D009164:Mycobacterium Infections / Q000175:diagnosis* / Q000382:microbiology; D015269:Mycobacterium avium Complex / Q000302:isolation & purification; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010538:Peritonitis / Q000382:microbiology*