[Effect of the long-term intake of yttrium in drinking water on trace elements in F1 generation mice].
The effects of the long-term intake of yttrium on trace elements in tissues and yttrium in brain of F1 generation mice were studied so as to elucidate some physiological function of the rare earths. The mice were fed with Y3+ (0, 23.25 mg/L, 2325.00 mg/L) dissolved water at different levels for seven months. The level of trace elements such as Cu, Cd, Pb and Y in brain and Se in brain, liver, spleen and kidney of F1 generation mice were measured by ICP-MS and atom fluorescent method. The results showed that, compared with control mice, significant changes in content of Se (P < 0.05) in spleen and Y (P < 0.05) in brain were observed, but no changes were found in content of Pb, Cd, and Cu in brain for the high dose group, and an increase was detected in content of Se(P < 0.05) in spleen for the low dose group, suggesting that long-term intake of Y3+ might enhance the absorption of Se in some tissue that might be one of the biological effect of rare earth and, Y3+ might enter young mammalian brain.
Yang
Weidong
W
Department of Biotechnology, Jinan University, Guangzhou 510632, China.
Liu
Jiesheng
J
Shen
Zhiguo
Z
Wu
Chunli
C
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000378:metabolism; D014131:Trace Elements / Q000378:metabolism*; D015019:Yttrium / Q000008:administration & dosage / Q000493:pharmacokinetics*
D014131:Trace Elements; D015019:Yttrium