Maintaining the permeability barrier during protein trafficking at the endoplasmic reticulum membrane.
Many proteins are translocated across or integrated into a cellular membrane without disrupting its integrity, although it is difficult to imagine how such macromolecular transmembrane movement can occur without simultaneously allowing significant small-molecule and ion diffusion across the bilayer. Recent studies have identified some molecular mechanisms that are involved in maintaining the permeability barrier of the endoplasmic reticulum membrane during co-translational protein translocation and integration. These mechanisms are both simple and direct in concept, but are operationally complex and require the co-ordinated and regulated interaction of several multicomponent complexes.
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Department of Medical Biochemistry and Genetics, College of Medicine, 116 Reynolds Medical Building, Texas A&M University System Health Science Center, 1114 TAMU, College Station, TX 77843-1114, U.S.A. aejohnson@tamu.edu
D002463:Cell Membrane Permeability; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism*; D021381:Protein Transport