Ischemic and hemorrhagic disturbances in cerebral circulation alter contractile responses of the rat middle cerebral artery.
In our study, we examined middle cerebral artery (MCA) contractile responses in two animal models. After hemorrhagic disturbances in rats of Krushinsky-Molodkina strain (KMRs) a decrease in contractile responses to serotonin (5-HT) was observed. During incomplete global cerebral ischemia, MCAs had increased responsiveness to endothelin-1 (ET-1), but reduced responsiveness to serotonin. These findings suggest that cerebral circulation disorders alter cerebrovascular function possibly leading to secondary disturbances in brain circulation.
Fadyukova
Olga E
OE
Faculty of Medicine, Lomonosov Moscow State University, Lomonosovsky Pr., 31/5 Moscow 117192, Russia. olevfa@fbm.msu.ru
Storozhevykh
Tatiana P
TP
Pinelis
Vsevolod G
VG
Koshelev
Vladimir B
VB
D000818:Animals; D002545:Brain Ischemia / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D019332:Endothelin-1 / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D008297:Male; D020768:Middle Cerebral Artery / Q000187:drug effects / Q000503:physiopathology*; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*
D019332:Endothelin-1; D012701:Serotonin