Antibody-directed enzyme-prodrug therapy.
Pedley
R Barbara
RB
Cancer Research UK Targeting and Imaging Group, Department of Oncology, Royal Free and University College Medical School, London, UK.
Sharma
Surinder K
SK
Hawkins
Robert E
RE
Chester
Kerry A
KA
D000818:Animals; D000906:Antibodies / Q000235:genetics* / Q000627:therapeutic use; D000951:Antigens, Neoplasm / Q000276:immunology; D001483:Base Sequence; D017931:DNA Primers; D004798:Enzymes / Q000235:genetics*; D005818:Genetic Engineering / Q000379:methods; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D008727:Methotrexate / Q000493:pharmacokinetics / Q000627:therapeutic use; D051379:Mice; D008954:Models, Biological; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D016133:Polymerase Chain Reaction / Q000379:methods; D011355:Prodrugs / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011623:gamma-Glutamyl Hydrolase / Q000235:genetics / Q000378:metabolism
D000906:Antibodies; D000951:Antigens, Neoplasm; D017931:DNA Primers; D004798:Enzymes; D011355:Prodrugs; D011623:gamma-Glutamyl Hydrolase; D008727:Methotrexate