title: Enzyme-prodrug systems: carboxylesterase/CPT-11.
authors.affiliation: Department of Molecular Pharmacology, St. Jude Children's Research Hospital, Memphis, TN, USA.
authors.forename: Mary K
authors.initials: MK
authors.lastname: Danks
authors.forename: Philip M
authors.initials: PM
authors.lastname: Potter
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000493:pharmacokinetics / Q000627:therapeutic use / Q000633:toxicity; D001711:Biotransformation; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics* / Q000627:therapeutic use / Q000633:toxicity; D043182:Carboxylesterase / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D002265:Carboxylic Ester Hydrolases / Q000235:genetics / Q000378:metabolism; D041722:Genes, Transgenic, Suicide; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D000077146:Irinotecan; D008099:Liver / Q000201:enzymology; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000188:drug therapy*; D011355:Prodrugs / Q000493:pharmacokinetics* / Q000627:therapeutic use / Q000633:toxicity; D011817:Rabbits; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D011355:Prodrugs; D000077146:Irinotecan; C072888:CPT-11 converting enzyme; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase; D002166:Camptothecin