Diagnostic value of sural nerve matrix metalloproteinase-9 in diabetic patients with CIDP.
Patients with diabetes mellitus (DM) may develop chronic inflammatory demyelinating polyneuropathy (CIDP), which may be difficult to distinguish from diabetic neuropathy (DNP). Here the authors show that immunoreactivity for matrix metalloproteinase-9 on sural nerve biopsies may help to identify CIDP-DM. In a pilot study on 10 CIDP-DM patients with IV immunoglobulins and tight glycemic control, the CIDP-DM patients had a better outcome than DNP patients treated with tight glycemic control only.
Jann
S
S
Department of Neurology, Vimercate Hospital, Milan, Italy.
Bramerio
M A
MA
Beretta
S
S
Koch
S
S
Defanti
C A
CA
Toyka
K V
KV
Sommer
C
C
D000328:Adult; D000368:Aged; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000188:drug therapy; D003929:Diabetic Neuropathies / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000032:analysis* / Q000276:immunology; D008875:Middle Aged; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D013497:Sural Nerve / Q000201:enzymology* / Q000473:pathology
D020780:Matrix Metalloproteinase 9