title: [Neuropsychiatric systemic lupus erythematosus associated with anti-phospholipid syndrome, showing massive intracranial calcifications].
abstract: We report a 46-year-old woman who extensively showed intracranial calcifications possibly due to neuropsychiatric systemic lupus erythematosus (NPSLE) and antiphospholipid syndrome (APS). She had been treated with oral prednisolone for SLE since age 15, and experienced two abortions due to APS at ages 28 and 35 respectively. After a convulsion attack due to NPSLE at age 30, she had been suffering from dysarthria and choreic movement in her extremities. On admission to our hospital brain CT demonstrated extensive and symmetrical calcifications bilaterally in basal ganglia, subcortical white matter of the frontal lobe and dentate nuclei. She was shown to have neither metabolic nor congenital disorders causing these intracranial abnormalities. In this patient both NPSLE and APS, therefore, might have contributed to the remarkable intracranial calcifications in a long clinical course.
authors.affiliation: Third Department of Medicine, Shinshu University School of Medicine, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shimojima
authors.forename: Takahisa
authors.initials: T
authors.lastname: Gono
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hoshi
authors.forename: Kanji
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Yoshida
authors.forename: Masayuki
authors.initials: M
authors.lastname: Matsuda
authors.forename: Shu-ichi
authors.initials: S
authors.lastname: Ikeda
mesh_terms: D016736:Antiphospholipid Syndrome / Q000150:complications*; D001927:Brain Diseases / Q000209:etiology*; D002114:Calcinosis / Q000209:etiology*; D005260:Female; D006801:Humans; D020945:Lupus Vasculitis, Central Nervous System / Q000150:complications*; D008875:Middle Aged