title: Screening test data analysis for liver disease prediction model using growth curve.
abstract: This study was done based on screening test data accumulated from 1994 to 2001 for studying of risk factor related with liver disease and prediction model of liver disease. In the existing study related with liver, the main current is studying on liver cancer, not on liver disease, previous step into liver cancer. As a result of estimating prediction model through the risk factors of liver disease and the growth curve on the basis of data, it is shown that most of the risk factors about liver disease are also those about known well as liver cancer. In addition, to investigate liver disease prevalence from the viewpoint of the future, this study presumed risk factor through the various growth curve analysis and examined logistic regression, decision tree and neural network from those estimators. In the case of neural network using growth curve estimator of Xi(5)=alphai+betaiT+epsiloniT, accuracy of liver disease was 72.55% and sensitivity was 78.62%. On the other hand, in the case of liver disease prediction model using recent screening test data estimator, accuracy was 72.09% and sensitivity was 71.72%. Those are lower than liver disease prediction model of growth curve analysis. In the various liver disease prediction models assumed by growth curve and many distinction models, when growth curve estimator was used, sensitivity value was improved.
authors.affiliation: Bioanalysis Biotransformation and Research Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, South Korea.
authors.forename: Young Sun
authors.initials: YS
authors.lastname: Kim
authors.forename: So Young
authors.initials: SY
authors.lastname: Sohn
authors.forename: Dong Kee
authors.initials: DK
authors.lastname: Kim
authors.forename: Donggeon
authors.initials: D
authors.lastname: Kim
authors.forename: Yong Han
authors.initials: YH
authors.lastname: Paik
authors.forename: Ho Shik
authors.initials: HS
authors.lastname: Shim
mesh_terms: D006801:Humans; D008107:Liver Diseases / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology; D008954:Models, Biological; D016571:Neural Networks, Computer; D011379:Prognosis; D012372:ROC Curve; D012307:Risk Factors