title: Effects of atorvastatin and pravastatin on glucose tolerance in diabetic rats mildly induced by streptozotocin.
abstract: Effects of atorvastatin and pravastatin on glucose tolerance in mildly induced diabetic rats by streptozotocin at 24 mg/kg, i.v. were studied. Non-diabetic and diabetic rats were given orally 0.5% carboxymethylcellulose (control), 8 mg/kg atorvastatin or 8 mg/kg pravastatin once a day for 6 weeks. An oral glucose tolerance test (OGTT) was carried out 1, 2, 3, and 6 weeks after the administration. The blood glucose and plasma insulin levels measured before OGTT in the diabetic rats were not different from those in the non-diabetic rats. However, the hyperglycemic response to OGTT in the diabetic rats significantly exceeded that in the non-diabetic rats. The plasma insulin increased by OGTT in the diabetic rats appeared to be lower than that in the non-diabetic rats. Statin treatments for 1 week did not modify the OGTT-induced hyperglycemia appreciably, although there were some significant differences. More than 2 weeks after administration, the blood glucose levels at several time points after a glucose intake in the atorvastatin-treated diabetic rats were significantly higher than the respective levels in the control diabetic rats. Neither atorvastatin nor pravastatin modified the OGTT-induced insulin secretion. Statins, especially atorvastatin, may influence the glucose tolerance in mildly induced diabetic rats without alterations of insulin secretion.
authors.affiliation: Department of Pharmacology, Hokkaido College of Pharmacy, Katsuraoka, Otaru, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Kanda
authors.forename: Kumi
authors.initials: K
authors.lastname: Satoh
authors.forename: Kazuo
authors.initials: K
authors.lastname: Ichihara
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000069059:Atorvastatin; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004347:Drug Interactions; D005947:Glucose / Q000008:administration & dosage; D005951:Glucose Tolerance Test / Q000009:adverse effects* / Q000379:methods; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D007275:Injections, Intravenous; D007328:Insulin / Q000096:biosynthesis / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D017035:Pravastatin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011758:Pyrroles / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D013311:Streptozocin / Q000008:administration & dosage / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D006538:Heptanoic Acids; D007328:Insulin; D011758:Pyrroles; D013311:Streptozocin; D000069059:Atorvastatin; D005947:Glucose; D017035:Pravastatin