Case-control study of the alpha-synuclein interacting protein gene and Parkinson's disease.
We conducted a case-control study of the alpha-synuclein-interacting protein gene (SNCAIP, also known as synphilin-1) and Parkinson's disease (PD). A total of 319 PD cases and 195 controls were genotyped for four SNCAIP variants, including a microsatellite repeat in intron 4 and three restriction fragment length polymorphisms (RFLP) proximal to the 5' terminal of exons 1, 4, and 6. None of the variants were found associated with PD overall. Global score statistics were not significant for four, three, and two loci haplotypes. All four loci were in linkage disequilibrium for cases, controls, or both groups combined (P < 0.0001). Recursive partitioning showed no interactions between variants of the SNCAIP gene and variants of the alpha-synuclein gene (SNCA) or the parkin (PARK2) gene.
Maraganore
Demetrius M
DM
Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA. dmaraganore@mayo.edu
Farrer
Matthew J
MJ
Lesnick
Timothy G
TG
de Andrade
Mariza
M
Bower
James H
JH
Hernandez
Dena
D
Hardy
John A
JA
Rocca
Walter A
WA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D005091:Exons / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism*; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism*; D017354:Point Mutation / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D016037:Single-Blind Method; D051843:Synucleins; D044767:Ubiquitin-Protein Ligases / Q000235:genetics; D051844:alpha-Synuclein
D002352:Carrier Proteins; D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; C118958:SNCAIP protein, human; D051843:Synucleins; D051844:alpha-Synuclein; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein