[The study on specific anti-Streptococcus mutans IgY against dental caries in rats].
OBJECTIVE
To investigate the effect of specific anti-streptococcus mutans IgY against streptococcus mutans on dental caries development in rats.


METHODS
35 wistar rats were divided into 5 groups: group A received IgY gargle; group B received IgY lyophilized powder; group C received sterilized water as control; group D and E received egg yolk food with or without specific IgY individually. They were all fed with caries-inducing diet 2000#. The number of caries scores was counted by the procedure of Keyes'.


RESULTS
There was a significant lower mean of caries scores in groups treated with IgY lyophilized powder and gargle. By treating with egg-yolk food contained specific IgY, the mean of caries scores decreased comparing with no treatment group.


CONCLUSIONS
Local passive immunization with specific anti-streptococcus mutans IgY may be an effective way to prevent the development of dental caries.
Fan
Mingwen
M
Department of Endodontics, College of Stomatology, Wuhan University, Wuhan 430070, China.
Jiang
Qianzhou
Q
Bian
Zhuan
Z
D000818:Animals; D000907:Antibodies, Bacterial / Q000008:administration & dosage; D003731:Dental Caries / Q000517:prevention & control*; D005260:Female; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000276:immunology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D022541:Streptococcal Vaccines / Q000276:immunology*; D013295:Streptococcus mutans / Q000276:immunology*
D000907:Antibodies, Bacterial; C016512:IgY; D007136:Immunoglobulins; D022541:Streptococcal Vaccines