title: [Study of midazolam for premedication in oral and maxillofacial surgery].
abstract: OBJECTIVE
  To study the effects of midazolam for premedication in oral-maxillofacial surgery.
  
  
  METHODS
  60 patients were selected and divided into 3 groups equally with 20 cases in each group. Different drugs were used for premedication. Group received midazolam 0.06 mg/kg, group received diazepam 0.12 mg/kg, group received luminal 3 mg/kg, Intramuscular injections of drugs were finished before 30 minutes of anesthesia. The sedative and anxiolytic effects, the changes of circulation and respiration and the side effects were evaluated.
  
  
  RESULTS
  In group, BIS (bispectral analysis of electroencephalogram) decreased obviously and Ramsay score increased significantly 5 minutes after drug administration, AVAT(Anxiety visual analog test) and SAI(State anxiety inventory) decreased obviously 30 minutes after administration drug (P < 0.05). But no significant changes in the other groups (P > 0.05). There were no remarkable changes of circulation and respiration in the three groups. No severe side effects were observed after premedication.
  
  
  CONCLUSIONS
  The premedication of using midazolam has good sedative and anxiolytic effects and few side effects.
authors.affiliation: Department of Anesthesiology, Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhu
authors.forename: Xu
authors.initials: X
authors.lastname: Wang
authors.forename: Ye-sen
authors.initials: YS
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008297:Male; D008874:Midazolam / Q000494:pharmacology*; D008875:Middle Aged; D019647:Oral Surgical Procedures; D011229:Preanesthetic Medication; D012119:Respiration / Q000187:drug effects
chemical_list: D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D008874:Midazolam