Acute electroretinographic changes during sildenafil (Viagra) treatment for erectile dysfunction.
The authors describe their findings on 12 subjects who were treated with 50 mg of sildenafil (Viagra) and underwent ERG measurements prior to and 1 hour after ingestion. The Naka-Rushton equation was used to describe the b-wave luminance-response function of the scotopic ERG. Statistically significant differences were noted in the Vmax and K values. Sildenafil ingestion resulted in an increase in Vmax (higher rod response to light stimuli) and a decrease in K (higher sensitivity).
Balacco Gabrieli
Corrado
C
Department of Ophthalmology, University of Rome La Sapienza, Rome, Italy. corrado.balacco@uniroma1.it
Regine
Federico
F
Vingolo
Enzo M
EM
Rispoli
Edoardo
E
Isidori
Aldo
A
D004596:Electroretinography; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects*; D010879:Piperazines / Q000009:adverse effects*; D011687:Purines; D012160:Retina / Q000187:drug effects* / Q000503:physiopathology*; D000068677:Sildenafil Citrate; D013450:Sulfones; D013997:Time Factors
D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate