Multimodal signal integration in vestibular neurons of the primate fastigial nucleus.
The rostral fastigial nucleus contains vestibular neurons, which presumably are involved in spinal mechanisms (neck, gait, posture) and which are not modulated with individual eye movements. Single-unit recordings in the alert behaving monkey during natural stimulus conditions reveal that virtually all neurons demonstrate integration of several sensory inputs. This applies not only for canal-canal and canal-otolith interaction, but also for otolith-otolith interaction. There is also some evidence that most neurons receive not only an utriculus but also a sacculus input. Furthermore, most neurons also respond to large-field optokinetic stimulation, reflecting visual-vestibular interaction. Neurons are also affected by the head on trunk position, which would allow these neurons to operate in a body-centered rather than a head-centered reference frame. These complex, multisensory features could permit fastigial nucleus neurons to rather specifically affect spinal motor functions.
Büttner
U
U
Department of Neurology, Ludwig-Maximilians University, 81377 Munich, Germany. ubeuttner@brain.nefo.med.uni-muenchen.de
Glasauer
S
S
Glonti
L
L
Guan
Y
Y
Kipiani
E
E
Kleine
J
J
Siebold
C
C
Tchelidze
T
T
Wilden
A
A
D000818:Animals; D002529:Cerebellar Nuclei / Q000502:physiology*; D019416:Head Movements / Q000502:physiology; D008251:Macaca; D009046:Motor Neurons / Q000502:physiology*; D010037:Otolithic Membrane / Q000502:physiology; D011187:Posture / Q000502:physiology; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology; D012399:Rotation; D012665:Semicircular Canals / Q000502:physiology; D014726:Vestibular Nuclei / Q000502:physiology*