title: Sex differences in the relationships of abdominal fat to cardiovascular disease risk among normal-weight white subjects.
abstract: The objectives of this study are to investigate the relationships between abdominal fat and risk factors for cardiovascular disease (CVD) among normal-weight (NW) white subjects and to determine how these relationships differ by sex. NW adults (177 males and 258 females) and overweight adults (133 males and 111 females) from the Québec Family Study and the HERITAGE Family Study were retained for this study. Risk factors included systolic and diastolic blood pressures, low-density lipoprotein and high-density lipoprotein cholesterols, triglycerides, and fasting glucose. Only in NW female adults, abdominal visceral fat (AVF) area assessed by computed tomography was significantly correlated with all risk factors, except for fasting glucose, even after age, study cohort, and fat mass were taken into account. NW female subjects with at least one risk factor had a significantly higher AVF than those without risk factors, although the difference was small. Thus, only NW female adults with more AVF tended to have a more adverse CVD risk factor profile.
authors.affiliation: Division of Human Nutrition, National Institute of Health and Nutrition, Shinjuku-ku, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Togashi
authors.forename: T
authors.initials: T
authors.lastname: Rankinen
authors.forename: L
authors.initials: L
authors.lastname: Pérusse
authors.forename: A S
authors.initials: AS
authors.lastname: Leon
authors.forename: D C
authors.initials: DC
authors.lastname: Rao
authors.forename: J S
authors.initials: JS
authors.lastname: Skinner
authors.forename: J H
authors.initials: JH
authors.lastname: Wilmore
authors.forename: J P
authors.initials: JP
authors.lastname: Després
authors.forename: C
authors.initials: C
authors.lastname: Bouchard
mesh_terms: D000005:Abdomen / Q000033:anatomy & histology*; D000273:Adipose Tissue / Q000033:anatomy & histology*; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000473:pathology; D012307:Risk Factors; D012727:Sex Characteristics
chemical_list: D001786:Blood Glucose; D008055:Lipids