Biology of human bone marrow stem cells.
The bone marrow is constituted of two separate and distinct stem cells. The hematopoietic stem cells (HSC) are responsible for the production and maintenance of all the mature blood cells. The mesenchymal stem cells constituted the bone marrow stroma. In this report we review our current understanding on both stem cell populations. We also discuss the recent unexpected degree of differentiation plasticity that have been reported recently and the impacts these new discoveries may have in stem cell therapy.
Bonnet
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Hematopoietic Stem Cell Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields, WC2A3PX London, UK. dominique.bonnet@cancer.org.uk
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology* / Q000502:physiology; D003114:Colony-Forming Units Assay / Q000379:methods; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D008648:Mesoderm / Q000166:cytology / Q000502:physiology; D051379:Mice; D016513:Mice, SCID