title: Outcome of patients with hepatitis C virus-related single, small hepatocellular carcinoma.
abstract: To clarify the cumulative recurrence-free interval and survival rate with hepatitis C virus (HCV)-related single, small hepatocellular carcinoma (HCC), we studied 32 patients with surgical resection, 61 with ablation therapy and 28 with transcatheter chemoembolization (TACE). A log-rank test revealed that there were no significant differences in the recurrence-free interval (p = 0.08) and survival (p = 0.279) between the resection and the ablation groups. Univariate analysis using the Cox proportional hazards regression model showed initial treatment (p = 0.0051) was associated with recurrence-free interval. Platelet count (p = 0.009), indocianine green retention rate at 15 minutes (p = 0.003), Child-Pugh classification (p = 0.001), serum albumin level (p = 0.0012) and serum total bililubin (p = 0.015) were associated with survival. Hence patients with HCV-related single, small HCC should be treated according to their hepatic reserve.
authors.affiliation: Division of Hepatology, Nanpuh Hospital, 14-3 Nagatacho, Kagoshima 892-8512, Japan. k-sako@nanpuh.or.jp
authors.forename: Katsumi
authors.initials: K
authors.lastname: Sako
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Komorizono
authors.forename: Makoto
authors.initials: M
authors.lastname: Oketani
authors.forename: Susumu
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Naruhiro
authors.initials: N
authors.lastname: Yamasaki
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Shibatou
authors.forename: Masahiko
authors.initials: M
authors.lastname: Maeda
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kohara
authors.forename: Shuhou
authors.initials: S
authors.lastname: Shigenobu
authors.forename: Hiramine
authors.initials: H
authors.lastname: Yasunari
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Sakurai
authors.forename: Takuya
authors.initials: T
authors.lastname: Hiwaki
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Ishibashi
authors.forename: Terukatsu
authors.initials: T
authors.lastname: Arima
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000601:surgery / Q000628:therapy* / Q000821:virology*; D017115:Catheter Ablation; D016461:Chemoembolization, Therapeutic; D018572:Disease-Free Survival; D005260:Female; D016174:Hepacivirus; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000601:surgery / Q000628:therapy* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome