[Episodes of depression with attempted suicide after taking valsartan with hydrochlorothiazide].
METHODS
A 43-year-old woman was admitted after a suicide attempt with 1.5 g atenolol. Physical and neurological examination showed no abnormality, but psychiatric examination revealed symptoms of a major depression. Four weeks prior to admission a valsartan-hydrochlorothiazide combination had been added to the antihypertensive medication.


METHODS
Laboratory tests, electrocardiography, chest-x-ray, electroencephalography and cranial computerised tomography showed no abnormality.


METHODS
The depressive disorder resolved within ten days after discontinuation of valsartan and hydrochlorothiazide without specific treatment. Blood pressure was normal under treatment with metoprolol.


CONCLUSIONS
Depressive drug reactions can produce a substantial morbidity. This case of a drug induced affective disorder should heighten the awareness of unusual reactions to valsartan-hydrochlorothiazide therapy.
Ullrich
H
H
Klinik für Psychiatrie, Psychotherapie und Psychosomatik, Evangelische Kliniken Gelsenkirchen, Germany. heiko.ullrich@ruhr-uni-bochum.de
Passenberg
P
P
Agelink
M W
MW
D000328:Adult; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003863:Depression / Q000139:chemically induced*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects* / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy; D013406:Suicide, Attempted; D013777:Tetrazoles / Q000009:adverse effects* / Q000627:therapeutic use; D014633:Valine / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000627:therapeutic use; D000068756:Valsartan
D000959:Antihypertensive Agents; D013777:Tetrazoles; D006852:Hydrochlorothiazide; D000068756:Valsartan; D014633:Valine