Mycobacterium avium subsp. paratuberculosis infection causes suppression of RANTES, monocyte chemoattractant protein 1, and tumor necrosis factor alpha expression in peripheral blood of experimentally infected cattle.
Blood from cattle with subclinical Mycobacterium avium subsp. paratuberculosis infection was stimulated with M. avium subsp. paratuberculosis antigens, and expression of interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), RANTES, monocyte chemoattractant protein 1 (MCP-1), and IL-8 was measured. Expression of TNF-alpha, RANTES, and MCP-1 was lower in infected than in uninfected cattle. The reduced response may weaken protective immunity and perpetuate infection.
Buza
Joram J
JJ
Paratuberculosis and Inflammatory Bowel Disease Research Team, National Institute of Animal Health, 3-1-5 Kan-nondai, Tsukuba 305-0856, Japan.
Mori
Yasuyuki
Y
Bari
Abusaleh M
AM
Hikono
Hirokazu
H
Aodon-geril
Hirayama
Sachiyo
S
Shu
Yujing
Y
Momotani
Eiichi
E
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*; D018932:Chemokine CCL2 / Q000097:blood*; D018946:Chemokine CCL5 / Q000097:blood*; D016927:Mycobacterium avium subsp. paratuberculosis / Q000472:pathogenicity*; D010283:Paratuberculosis / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D018932:Chemokine CCL2; D018946:Chemokine CCL5; D014409:Tumor Necrosis Factor-alpha