Buckwheat concentrate reduces serum glucose in streptozotocin-diabetic rats.
The antihyperglycemic effects of chemically synthesized d-chiro-inositol (d-CI), a component of an insulin mediator, have been demonstrated in rats. Buckwheat contains relatively high levels of d-CI: thus, it has been proposed as a source of d-CI for reducing serum glucose concentrations in diabetics. The present study evaluates the effects of a buckwheat concentrate, containing d-CI, on hyperglycemia and glucose tolerance in streptozotocin (STZ) rats. In fed STZ rats, both doses of the buckwheat concentrate (containing 10 and 20 mg of d-CI/kg of body weight) were effective for lowering serum glucose concentrations by 12-19% at 90 and 120 min after administration. Findings from this study demonstrate that a buckwheat concentrate is an effective source of d-CI for lowering serum glucose concentrations in rats and therefore may be useful in the treatment of diabetes.
Kawa
Julianne M
JM
Department of Human Nutritional Sciences, University of Manitoba, H505 Duff Roblin Building, 190 Dysart Road, Winnipeg, Manitoba, Canada R3T 2N2.
Taylor
Carla G
CG
Przybylski
Roman
R
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D019612:Fagopyrum / Q000737:chemistry*; D005215:Fasting; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007295:Inositol Phosphates / Q000008:administration & dosage / Q000032:analysis; D007700:Kinetics; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D011134:Polysaccharides / Q000008:administration & dosage / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry*
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007295:Inositol Phosphates; D010936:Plant Extracts; D011134:Polysaccharides; C028039:inositol phosphate glycan