title: [Dopamine and kidney in sepsis: a systematic review].
abstract: Acute renal failure has a high morbidity and mortality in critically ill patients. Severe sepsis and septic shock are important risk factors for the development of acute renal failure. Low-dose dopamine (0.5 to 3 mg/kg/min) has been used for decades as a renal-protective therapy in such patients, even in the absence of any controlled study to support this concept.
  
  
  BACKGROUND
  To Check the literature for evidences supporting the routine use of low-dose dopamine in severe sepsis and septic shock.
  
  
  METHODS
  Systematic review of the literature, on electronic databasis (MEDLINE, EMBASE and LILACS), and handsearching.
  
  
  RESULTS
  Only five randomized clinical trials were found, but none of them studied renal outcomes. Eight cases series studies were included on a qualitative review. Dopamine was associated with some adverse effects, such as increase in pulmonary shunting, tachyarrhythmias, and increase in pulmonary artery pressure, that were not statistically significant. Mortality also did not change with the use of dopamine.
  
  
  CONCLUSIONS
  There are no sufficient evidences in the literature to support the routine use of low-dose dopamine as a renal protective agent in severe sepsis and septic shock.
authors.affiliation: Unidade de Terapia Intensiva do Instituto da Criança do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Denise Varella
authors.initials: DV
authors.lastname: Katz
authors.forename: Eduardo Juan
authors.initials: EJ
authors.lastname: Troster
authors.forename: Flavio Adolfo Costa
authors.initials: FA
authors.lastname: Vaz
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004298:Dopamine / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012772:Shock, Septic / Q000150:complications / Q000188:drug therapy*
chemical_list: D004298:Dopamine