At the crossroads of skeletal responses to estrogen and exercise.
The recent observation that mice deficient in estrogen receptor alpha (ERalpha) have an impaired response to mechanical strain suggests that ERalpha plays an important role in mediating the response of the skeleton to mechanical loading as well as to estrogen. In view of previous findings that estrogen deficiency leads to a fall in ERalpha numbers, postmenopausal bone loss might result from the impaired response of bone to mechanical strain caused by deficient ERalpha signalling.
Tobias
Jonathan H
JH
Rheumatology Unit, Bristol Royal Infirmary, BS2 8HW, Bristol, UK. Jon.Tobias@bristol.ac.uk
D000818:Animals; D001842:Bone and Bones / Q000502:physiology*; D047628:Estrogen Receptor alpha; D004967:Estrogens / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D006801:Humans; D005082:Physical Exertion / Q000502:physiology*; D011960:Receptors, Estrogen / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013314:Stress, Mechanical
D047628:Estrogen Receptor alpha; D004967:Estrogens; D011960:Receptors, Estrogen