Palladium-catalyzed regioselective arylation of imidazo[1,2-a]pyrimidine.
Imidazo[1,2-a]pyrimidine can be arylated at the 3-position with aryl bromides in the presence of base and a catalytic amount of palladium. This provides an efficient one-step synthesis of 3-arylimidazo[1,2-a]pyrimidines from the unsubstituted heterocycle. [reaction: see text]
Li
Wenjie
W
Process Research Department, Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA. wenjie_li@merck.com
Nelson
Dorian P
DP
Jensen
Mark S
MS
Hoerrner
R Scott
RS
Javadi
Gary J
GJ
Cai
Dongwei
D
Larsen
Robert D
RD