title: Acetazolamide as a vasodilatory stimulus in cerebrovascular diseases and in conditions affecting the cerebral vasculature.
abstract: Pathologic processes affecting the brain vessels may damage cerebral vasodilatory capacity. Early detection of cerebral dysfunction plays an important role in the prevention of cerebrovascular diseases. In recent decades acetazolamide (AZ) has frequently been used for this purpose. In the present work the mechanism of action and the previous studies are reviewed. The authors conclude that AZ tests are useful in cerebrovascular research. Further investigations are recommended to prove how impaired reserve capacity and reactivity influence the stroke risk in patients and whether these tests may indicate therapeutic interventions.
authors.affiliation: Department of Neurology, Health and Medical Science Center, University of Debrecen, Debrecen, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Settakis
authors.forename: C
authors.initials: C
authors.lastname: Molnár
authors.forename: L
authors.initials: L
authors.lastname: Kerényi
authors.forename: J
authors.initials: J
authors.lastname: Kollár
authors.forename: D
authors.initials: D
authors.lastname: Legemate
authors.forename: L
authors.initials: L
authors.lastname: Csiba
authors.forename: B
authors.initials: B
authors.lastname: Fülesdi
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use*; D000375:Aging / Q000502:physiology; D000818:Animals; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D012727:Sex Characteristics; D020521:Stroke / Q000188:drug therapy / Q000503:physiopathology; D014665:Vasodilator Agents
chemical_list: D014665:Vasodilator Agents; D000086:Acetazolamide