Effect of beta-adrenoceptor blockade on cardiac activity in rats during postnatal ontogeny.
Electrical stimulation of the right stellate ganglion produces a positive chronotropic effect in 21-, 56-, and 100-day-old rats. The response of the heart rate to suprathreshold stimulation increased from the 21st to 100th day. By contrast, during beta-adrenoceptor blockade the heart rate response decreased. The data suggest that the role of beta-adrenoceptor in the regulation of cardiac chronotropic function increased with age.
Anikina
T A
TA
Department of Anatomy, Physiology, and Human Health Protection, Kazan' State Pedagogical University.
Bilalova
G A
GA
Sitdikov
F G
FG
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000375:Aging; D000818:Animals; D001835:Body Weight; D004594:Electrophysiology; D005268:Femoral Vein / Q000378:metabolism; D006339:Heart Rate; D009206:Myocardium / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D013233:Stellate Ganglion / Q000473:pathology; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D011433:Propranolol