title: Cognitive change 5 years after coronary artery bypass surgery.
abstract: A longitudinal study of cognitive function after coronary artery bypass surgery examined 107 participants using 11 tests, preoperatively and at 6 days, 8 weeks, and 5 years after surgery. The overall neuropsychological (NP) change score declined at 6 days, showed some recovery at 8 weeks, and declined again at 5 years. The number of microemboli recorded during surgery, postoperative short-term cognitive change, and degree of recovery at 8 weeks were identified as predictors of change in NP score to 5 years. This suggests that even over a 5-year period, operative damage is detectable. Patients' vulnerability to short-term deterioration and resilience or ability to recover over a few weeks from operative cerebral insult are important processes of unknown mechanisms.
authors.affiliation: Unit of Health Psychology, Centre for Behavioural and Social Sciences in Medicine, University College London, London, United Kingdom.
authors.forename: Jan
authors.initials: J
authors.lastname: Stygall
authors.forename: Stanton P
authors.initials: SP
authors.lastname: Newman
authors.forename: Geraldine
authors.initials: G
authors.lastname: Fitzgerald
authors.forename: Liz
authors.initials: L
authors.lastname: Steed
authors.forename: Kathleen
authors.initials: K
authors.lastname: Mulligan
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Arrowsmith
authors.forename: Wilfred
authors.initials: W
authors.lastname: Pugsley
authors.forename: Steve
authors.initials: S
authors.lastname: Humphries
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Harrison
mesh_terms: D000081:Acetamides / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000368:Aged; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000523:psychology; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D001026:Coronary Artery Bypass / Q000009:adverse effects* / Q000523:psychology*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D020766:Intracranial Embolism / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000627:therapeutic use; D009483:Neuropsychological Tests; D011183:Postoperative Complications / Q000523:psychology*; D011184:Postoperative Period; D013997:Time Factors
chemical_list: D000081:Acetamides; D018696:Neuroprotective Agents; C067553:remacemide