Early growth response-1: blocking angiogenesis by shooting the messenger.
Early growth response-1 (Egr-1) is an immediate early gene, which encodes a zinc finger transcription factor. Recent evidence indicates that Egr-1 plays a crucial role in angiogenesis, the formation of new blood vessels from the pre-existing vasculature. DNAzymes (catalytic single-stranded DNA) targeting the Egr-1 mRNA inhibit Egr-1 and FGF-2 expression, block endothelial cell growth, and suppress neovascularization and tumor angiogenesis in various animal models.
Khachigian
Levon M
LM
Centre for Vascular Research, Department of Pathology, University of New South Wales, Sydney, NSW 2052, Australia. L.Khachigian@unsw.edu.au
D000818:Animals; D002455:Cell Division / Q000502:physiology; D021881:DNA, Catalytic / Q000378:metabolism; D042783:Endothelial Cells / Q000378:metabolism; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D051379:Mice; D023421:Models, Animal; D009374:Neoplasms, Experimental / Q000098:blood supply; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D012333:RNA, Messenger / Q000037:antagonists & inhibitors / Q000378:metabolism*
D021881:DNA, Catalytic; D012333:RNA, Messenger; D016222:Fibroblast Growth Factor 2