[Barrett's esophagus: new developments in endoscopic surveillance].
The current surveillance strategies for patients with a Barrett's oesophagus are hampered by the poor endoscopic visibility of early neoplastic lesions, the sampling error of random biopsies, the subjectivity of the histological evaluation, and the low incidence of carcinoma. New endoscopic techniques are available for a more reliable evaluation of a Barrett's oesophagus: high-resolution endoscopy, chromoendoscopy, fluorescence endoscopy and optical coherence tomography. The use of molecular markers will probably lead to a better risk stratification of patients. Detection of aneuploid cell populations and assessment of an increase of the number of cells in the S- and G2-phase are possible with DNA flow cytometry; flow cytometric abnormalities may be a more reliable predictor of carcinoma than histological assessment. A combined approach with the new endoscopic techniques and molecular markers may lead to a more efficient and cost-effective surveillance programme.
Marsman
W A
WA
Academisch Medisch Centrum, afd. Maag-, Darm- en Leverziekten, Meibergdreef 9, 1105 AZ Amsterdam.
Krishnadath
K K
KK
Fockens
P
P
Tytgat
G N
GN
Bergman
J J
JJ
D001471:Barrett Esophagus / Q000175:diagnosis*; D002453:Cell Cycle; D004938:Esophageal Neoplasms / Q000175:diagnosis; D004945:Esophagoscopy / Q000379:methods / Q000639:trends; D004947:Esophagus / Q000166:cytology / Q000473:pathology; D005434:Flow Cytometry; D006801:Humans; D011230:Precancerous Conditions / Q000175:diagnosis