Mice deficient for the close homologue of the neural adhesion cell L1 (CHL1) display alterations in emotional reactivity and motor coordination.
Motor and cognitive phenotypes were assessed in mice deficient for the close homologue of the L1 adhesion molecule (CHL1). The CHL1-deficient mice displayed signs of decreased stress and a modification of exploratory behaviour. The mice also showed motor impairments on the Rotarod, but they were able to move as fast as controls in the alleys of a T-maze. The observed changes were assumed to be related to a deficit in attention. In addition, gender differences in CHL1 deficits were found and are discussed in view of a possible interaction with other cell adhesion molecules (CAMs) during development. The results are discussed in relation with motor and cognitive deficits in the human, caused by mutations of the distal part of the chromosome 3 which contains the CHL1 orthologue.
Pratte
M
M
Institut de Neurosciences Physiologiques et Cognitives, CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille 20, France. pratte@dpm.cnrs-mrs.fr
Rougon
G
G
Schachner
M
M
Jamon
M
M
D000818:Animals; D001824:Body Constitution / Q000235:genetics; D001835:Body Weight / Q000235:genetics; D015815:Cell Adhesion Molecules; D004644:Emotions / Q000502:physiology*; D005106:Exploratory Behavior; D005260:Female; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008565:Membrane Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout / Q000502:physiology*; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time; D012420:Running; D012737:Sex Factors; D013997:Time Factors
C490650:CHL1 protein, human; D015815:Cell Adhesion Molecules; C490649:Chl1 protein, mouse; D008565:Membrane Proteins; D011506:Proteins