Protein-losing gastroenteropathy and retinitis associated with cytomegalovirus infection in an immunocompetent infant: a case report.
A 6-week-old immunocompetent girl developed protein-losing gastroenteropathy (PLGE) and retinitis associated with cytomegalovirus (CMV) infection. At presentation, CMV antigenaemia (6 cells/46,000 white blood cells) and its DNA were detected in the patient's blood and in the mother's milk. Intravenous ganciclovir and gamma-globulin rapidly ameliorated all symptoms and CMV antigenaemia disappeared. No immunological defects were identified in this patient. To the best of our knowledge, this case involves the youngest known immunocompetent patient demonstrating CMV-induced PLGE and retinitis.


CONCLUSIONS
breast-feeding by a cytomegalovirus-positive mother can be a primary cause of early onset cytomegalovirus infection in infants.
Iwanaga
Manabu
M
Department of Paediatrics, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, 849-8501 Saga, Japan.
Zaitsu
Masafumi
M
Ishii
Eiichi
E
Nishimura
Yoichi
Y
Inada
Shigeyasu
S
Yoshiki
Hiroka
H
Okinami
Satoshi
S
Hamasaki
Yuhei
Y
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D001942:Breast Feeding / Q000009:adverse effects*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008895:Milk, Human / Q000821:virology; D011504:Protein-Losing Enteropathies / Q000150:complications*; D012173:Retinitis / Q000150:complications*
D000998:Antiviral Agents; D015774:Ganciclovir