title: Case-control study of the alpha-synuclein interacting protein gene and Parkinson's disease.
abstract: We conducted a case-control study of the alpha-synuclein-interacting protein gene (SNCAIP, also known as synphilin-1) and Parkinson's disease (PD). A total of 319 PD cases and 195 controls were genotyped for four SNCAIP variants, including a microsatellite repeat in intron 4 and three restriction fragment length polymorphisms (RFLP) proximal to the 5' terminal of exons 1, 4, and 6. None of the variants were found associated with PD overall. Global score statistics were not significant for four, three, and two loci haplotypes. All four loci were in linkage disequilibrium for cases, controls, or both groups combined (P < 0.0001). Recursive partitioning showed no interactions between variants of the SNCAIP gene and variants of the alpha-synuclein gene (SNCA) or the parkin (PARK2) gene.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA. dmaraganore@mayo.edu
authors.forename: Demetrius M
authors.initials: DM
authors.lastname: Maraganore
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Farrer
authors.forename: Timothy G
authors.initials: TG
authors.lastname: Lesnick
authors.forename: Mariza
authors.initials: M
authors.lastname: de Andrade
authors.forename: James H
authors.initials: JH
authors.lastname: Bower
authors.forename: Dena
authors.initials: D
authors.lastname: Hernandez
authors.forename: John A
authors.initials: JA
authors.lastname: Hardy
authors.forename: Walter A
authors.initials: WA
authors.lastname: Rocca
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D005091:Exons / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism*; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism*; D017354:Point Mutation / Q000235:genetics; D012150:Polymorphism, Restriction Fragment Length; D016037:Single-Blind Method; D051843:Synucleins; D044767:Ubiquitin-Protein Ligases / Q000235:genetics; D051844:alpha-Synuclein
chemical_list: D002352:Carrier Proteins; D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; C118958:SNCAIP protein, human; D051843:Synucleins; D051844:alpha-Synuclein; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein