Effect of short follicular phase with follicular maturity on conception outcome.
OBJECTIVE
To determine if a short follicular phase despite attaining a mature follicle is associated with a lower pregnancy rate. Furthermore the study would determine if delaying the maturation of the follicle by the use of ethinyl estradiol could improve the pregnancy rate.


METHODS
The clinical and viable pregnancy rates of 32 infertile patients were matched to 32 similar controls who ovulated at or past day 11. After 2-3 cycles of demonstrating ovulation before day 11 some patients were treated with ethinyl E2, 20 mcg daily, from day 2 of the cycle until ovulation.


RESULTS
Clinical and viable pregnancy rates for the normal ovulators (84.4%, 59.3%) were significantly higher than the rates for early ovulators (21.8%, 9.3%). However, the pregnancy rates were 83.3% and 66.7% for the subset of early ovulators who were made to ovulate later by ethinyl E2.


CONCLUSIONS
The short follicular phase per se reduces fecundity.
Check
J H
JH
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, NJ, USA.
Liss
J R
JR
Shucoski
K
K
Check
M L
ML
D000328:Adult; D016022:Case-Control Studies; D002996:Clomiphene / Q000627:therapeutic use*; D015331:Cohort Studies; D005260:Female; D005306:Fertilization / Q000187:drug effects / Q000502:physiology; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D005498:Follicular Phase / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007247:Infertility, Female; D006080:Ovarian Follicle / Q000187:drug effects / Q000502:physiology*; D010060:Ovulation / Q000187:drug effects* / Q000502:physiology; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity
D002996:Clomiphene; D005640:Follicle Stimulating Hormone