title: Interactions of inertial cavitation bubbles with stratum corneum lipid bilayers during low-frequency sonophoresis.
abstract: Interactions of acoustic cavitation bubbles with biological tissues play an important role in biomedical applications of ultrasound. Acoustic cavitation plays a particularly important role in enhancing transdermal transport of macromolecules, thereby offering a noninvasive mode of drug delivery (sonophoresis). Ultrasound-enhanced transdermal transport is mediated by inertial cavitation, where collapses of cavitation bubbles microscopically disrupt the lipid bilayers of the stratum corneum. In this study, we describe a theoretical analysis of the interactions of cavitation bubbles with the stratum corneum lipid bilayers. Three modes of bubble-stratum corneum interactions including shock wave emission, microjet penetration into the stratum corneum, and impact of microjet on the stratum corneum are considered. By relating the mechanical effects of these events on the stratum corneum structure, the relationship between the number of cavitation events and collapse pressures with experimentally measured increase in skin permeability was established. Theoretical predictions were compared to experimentally measured parameters of cavitation events.
authors.affiliation: Department of Chemical Engineering, University of California, Santa Barbara, California 93106, USA.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Tezel
authors.forename: Samir
authors.initials: S
authors.lastname: Mitragotri
mesh_terms: D000162:Acoustics; D000535:Aluminum / Q000737:chemistry; D000818:Animals; D001703:Biophysics / Q000379:methods*; D004817:Epidermis / Q000378:metabolism*; D008051:Lipid Bilayers / Q000737:chemistry*; D015233:Models, Statistical; D011485:Protein Binding; D012867:Skin / Q000378:metabolism; D013552:Swine; D013997:Time Factors; D014465:Ultrasonics
chemical_list: D008051:Lipid Bilayers; D000535:Aluminum