title: Expression of fibroblast growth factor-2 (FGF-2) in early stages (days 3-11) of the development of the avian lung, Gallus gallus variant domesticus: an immunocytochemical study.
abstract: In the avian lung, the bronchial system forms from epithelial (endodermal) cells. The intrapulmonary primary bronchus is the focal point of airway development. It originates secondary bronchi (SB) along its proximal-distal extent and parabronchi (tertiary bronchi) arise from and connect the SB. From as early as day 3.5, fibroblast growth factor-2 (FGF-2) is diffusely expressed in the epithelial and mesenchymal cells. Up-regulation of FGF-2 in discrete areas of the developing lung seem to set the growth rate, trajectories followed, areas appropriated, three-dimensional symmetry and coupling of the airways. Expressed early in development and persisting into the incubation period, FGF-2 may be involved in the formation of the avian lung. Morphogenetic differences between the avian and the mammalian lungs may explain the existing structural contrarieties.
authors.affiliation: School of Anatomical Sciences, Faculty of Health Sciences, The University of the Witwatersrand, Johannesburg, South Africa. mainajn@anatomy.wits.ac.za
authors.forename: J N
authors.initials: JN
authors.lastname: Maina
authors.forename: A K
authors.initials: AK
authors.lastname: Madan
authors.forename: B
authors.initials: B
authors.lastname: Alison
mesh_terms: D000818:Animals; D002642:Chick Embryo; D004210:Dissection; D004847:Epithelial Cells / Q000737:chemistry; D016222:Fibroblast Growth Factor 2 / Q000032:analysis*; D005865:Gestational Age; D007150:Immunohistochemistry / Q000379:methods; D008168:Lung / Q000737:chemistry* / Q000196:embryology*; D008648:Mesoderm / Q000737:chemistry; D009024:Morphogenesis / Q000502:physiology
chemical_list: D016222:Fibroblast Growth Factor 2