[Expression of E-cadherin gene protein in oral verrucous carcinoma].
OBJECTIVE
To determine the relationship between E-cadherin over-expression and progression in oral verrucous carcinoma.


METHODS
Immunohistochemistry assay was performed on 12 cases of oral verrucous carcinoma (VC) and 20 cases of oral squamous epithelial cells carcinoma (SCC) using monoclonal antibody against E-cadherin gene protein.


RESULTS
The E-cadherin positive expression in VC (83.3%) was significantly higher than that in the poorly differentiated SCC(37.5%; P < 0.05), but the negative expression of E-cadherin in VC was between the well differentiated squamous cell carcinoma and the poorly differentiated squamous cell carcinoma.


CONCLUSIONS
E-cadherin over-expression plays an important role in oral verrucous carcinoma.
Tang
Zhan-gui
ZG
Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha 410078, China.
Zou
Ping
P
Xie
Xiao-li
XL
D000328:Adult; D015820:Cadherins / Q000096:biosynthesis* / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism; D018289:Carcinoma, Verrucous / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000235:genetics / Q000378:metabolism*
D015820:Cadherins