title: Prospective study of job insecurity and coronary heart disease in US women.
abstract: OBJECTIVE
  To examine prospectively the relationship between job insecurity and incidence of coronary heart disease (CHD) among women.
  
  
  METHODS
  We conducted the study in 36,910 women from the Nurses' Health Study, a prospective cohort of female registered nurses residing in 11 US states. These women were 46 to 71 years old, and did not have diagnosed CHD, stroke, or cancer at baseline (1992). We collected information on job insecurity in 1992 and coronary heart disease incidence between baseline (June 1, 1992) and return of the 1996 questionnaire.
  
  
  RESULTS
  During 4 years of follow-up, we documented 154 incident cases of CHD (113 non-fatal cases of myocardial infarction (MI) and 41 CHD deaths). After adjustment for a wide array of potential confounders, the relative risk (RR) of total CHD over 2-year follow-up was 1.35 (95% CI, 0.78-2.34) and 1.04 (95% CI, 0.69-1.57) over 4-year follow-up. Job insecurity appeared to significantly increase the risk of non-fatal MI in the short term (2-year follow-up: RR=1.89, 95% CI, 1.03-3.50), though not over a longer follow-up period (RR=1.28, 95% CI, 0.82-2.00), nor fatal CHD in the short term (RR=0.49, 95% CI, 0.22-2.08).
  
  
  CONCLUSIONS
  These data suggest that job insecurity may increase the short-term risk of non-fatal MI in women.
authors.affiliation: Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA.
authors.forename: Sunmin
authors.initials: S
authors.lastname: Lee
authors.forename: Graham A
authors.initials: GA
authors.lastname: Colditz
authors.forename: Lisa F
authors.initials: LF
authors.lastname: Berkman
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kawachi
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000453:epidemiology* / Q000209:etiology; D004651:Employment / Q000523:psychology*; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009726:Nurses / Q000523:psychology*; D016272:Occupational Health / Q000706:statistics & numerical data*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D012944:Social Support; D013315:Stress, Psychological / Q000150:complications* / Q000453:epidemiology; D011795:Surveys and Questionnaires; D035501:Uncertainty; D014481:United States / Q000453:epidemiology; D016387:Women's Health