title: Diphtheria: the patch remains.
abstract: This study analysed the number of patients admitted with diphtheria to a teaching hospital in the state of Assam in India over a period of five years and compared the disease characteristics and management with outcomes and incidences of diphtheria reported in the literature. It was a retrospective analysis of data elicited from clinical records of patients admitted to hospital. A total of 101 admissions were recorded during a five-year period between March 1997 to March 2002, mostly with pharyngeal diphtheria (90 per cent). The majority of patients had no history of immunization (70 per cent). Significant presenting features were a tonsillar patch, sore throat, respiratory distress and fever. All patients were treated with anti-diphtheritic serum and intravenous antibiotics. Steroids were given to 81 per cent of patients and tracheostomy was carried out in 10 per cent of cases. The mortality was 16 per cent. Diphtheria of the respiratory tract remains a potentially fatal disease commonly presenting with membranous pharyngitis. Early diagnosis and treatment with anti-diphtheritic serum and antibiotics remain the cornerstone of treatment. Inadequate immunization cover is deemed responsible for the continued menace of diphtheria.
authors.affiliation: Department of Otolaryngology, the Princess Margaret Hospital, Swindon, UK.
authors.forename: Raj
authors.initials: R
authors.lastname: Nandi
authors.forename: Mriganka
authors.initials: M
authors.lastname: De
authors.forename: Simon
authors.initials: S
authors.lastname: Browning
authors.forename: Prabhati
authors.initials: P
authors.lastname: Purkayastha
authors.forename: A K
authors.initials: AK
authors.lastname: Bhattacharjee
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004165:Diphtheria / Q000453:epidemiology* / Q000517:prevention & control / Q000628:therapy; D004166:Diphtheria Antitoxin / Q000627:therapeutic use; D004168:Diphtheria Toxoid / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007114:Immunization / Q000706:statistics & numerical data; D007194:India / Q000453:epidemiology; D008297:Male; D010612:Pharyngitis / Q000453:epidemiology* / Q000382:microbiology / Q000628:therapy; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D004166:Diphtheria Antitoxin; D004168:Diphtheria Toxoid