Association between the metabolic syndrome and newly diagnosed coronary artery disease.
This case-control study was designed to outline age- and gender-related differences of metabolic risk factors in a group of patients with coronary artery disease (CAD). Accordingly, a total of 366 consecutive patients with a recent diagnosis of CAD (139 women, 41-79 yr; 227 men, 39-78 yr) were screened between October 1999 and April 2001 at Baskent University Adana Medical Center, and 366 age- and gender-matched individuals were selected as a control group. We compared demographics, blood pressure, body mass index, waist circumference, lipid profile, fasting and post-prandial glucose-insulin levels between CAD patients and the control group. Prevalence of metabolic syndrome was 72.6% in females, and 39.0% in males with CAD. Hypertension, obesity and diabetes were more common in female patients; 64.5% of female patients had premature CAD and 83.5% of those had metabolic syndrome. In logistic (OR: 3.57 for women and OR: 1.59 for men) regression analysis, metabolic syndrome was independently associated with CAD in both genders. As a conclusion, prevalence of metabolic syndrome was significantly higher in patients with CAD than the control group, especially in female patients. The metabolic syndrome was independently associated with CAD in both genders.
Baltali
M
M
Department of Cardiology, Baskent University, Faculty of Medicine, Adana, Turkey.
Gokcel
A
A
Kiziltan
H T
HT
Korkmaz
M E
ME
Topcu
S
S
Yalcin
F
F
Demircan
S
S
Yigit
F
F
Ozin
B
B
Muderrisoglu
I H
IH
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D005215:Fasting / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology / Q000378:metabolism; D016015:Logistic Models; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism; D008875:Middle Aged; D019518:Postprandial Period / Q000502:physiology; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D013223:Statistics as Topic; D014280:Triglycerides / Q000097:blood; D014421:Turkey / Q000453:epidemiology
D015415:Biomarkers; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides