Mannosyl glycodendritic structure inhibits DC-SIGN-mediated Ebola virus infection in cis and in trans.
We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.
Lasala
Fátima
F
Laboratorio de Microbiología Molecular, Servicio de Microbiología, Hospital Universitario 12 de Octubre, Madrid, Spain.
Arce
Eva
E
Otero
Joaquín R
JR
Rojo
Javier
J
Delgado
Rafael
R
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D015815:Cell Adhesion Molecules / Q000187:drug effects*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D029043:Ebolavirus / Q000187:drug effects* / Q000254:growth & development; D019142:Hemorrhagic Fever, Ebola / Q000188:drug therapy* / Q000821:virology; D006801:Humans; D037181:Lectins, C-Type / Q000187:drug effects*; D016086:Lentivirus / Q000235:genetics; D008351:Mannans / Q000138:chemical synthesis* / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000187:drug effects*; D013237:Stereoisomerism; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects / Q000254:growth & development; D014759:Viral Envelope Proteins / Q000737:chemistry / Q000187:drug effects; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D000998:Antiviral Agents; D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D008351:Mannans; D011956:Receptors, Cell Surface; D014759:Viral Envelope Proteins; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C480354:BH30sucMan