title: Effects of lifestyle modification and lipid intake variations on patients with peripheral vascular disease.
abstract: The aim of the present study was to evaluate the effects of diets enriched in monounsaturated fatty acids (MUFA) (olive oil) or MUFA plus n-3 polyunsaturated fatty acids (PUFA) (olive oil plus fish oil), associated with an intervention program that focused on lifestyle habits, physical performance, plasma lipids, and lipoprotein composition in patients with peripheral vascular disease (PVD). A 15-month longitudinal nutritional and lifestyle intervention study was carried out with 24 free-living male patients aged 58.0 +/- 2.2 years diagnosed with PVD (Fontaine grade II). The patients were clinically evaluated and counseled to change their dietary and lifestyle habits for six months, after this period they consumed an olive oil-based diet for three months: after a three-month wash-out period, their diet was supplemented with a combination of fish oil and olive oil for the final three months. Lifestyle interventions resulted in a significant decrease in cigarette smoking and an increase in physical activity. Claudicometry was lower at the end of the study than at the beginning. Intake of the fish oil supplement led to significant changes in lipid lipoprotein composition, decreasing low-density lipoprotein (LDL) cholesterol. The lifestyle intervention program, together with a high intake of olive plus fish oil, seems to produce important beneficial effects in nutritional management, physical performance, and clinical parameters of PVD patients.
authors.affiliation: Institute of Nutrition and Food Technology, Department of Physiology, University of Granada.
authors.forename: Teresa
authors.initials: T
authors.lastname: Nestares
authors.forename: María
authors.initials: M
authors.lastname: López-Jurado
authors.forename: Gloria
authors.initials: G
authors.lastname: Urbano
authors.forename: Isabel
authors.initials: I
authors.lastname: Seiquer
authors.forename: María C
authors.initials: MC
authors.lastname: Ramírez-Tortosa
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ros
authors.forename: José
authors.initials: J
authors.lastname: Mataix
authors.forename: Angel
authors.initials: A
authors.lastname: Gil
mesh_terms: D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D015243:Cholesterol, VLDL / Q000097:blood / Q000187:drug effects; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000097:blood; D002149:Energy Intake / Q000187:drug effects / Q000502:physiology; D005080:Exercise Test; D005121:Extremities / Q000098:blood supply* / Q000473:pathology*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000097:blood; D005395:Fish Oils / Q000008:administration & dosage / Q000378:metabolism; D006801:Humans; D008019:Life Style; D008137:Longitudinal Studies; D008297:Male; D018977:Micronutrients / Q000008:administration & dosage; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D000069463:Olive Oil; D016491:Peripheral Vascular Diseases / Q000097:blood / Q000178:diet therapy*; D010938:Plant Oils / Q000008:administration & dosage / Q000378:metabolism; D040242:Risk Reduction Behavior; D012907:Smoking; D013030:Spain; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D005395:Fish Oils; D018977:Micronutrients; D000069463:Olive Oil; D010938:Plant Oils; D014280:Triglycerides