Acute methanol poisonings reported to the Drug and Poison Information Center in Izmir, Turkey.
The demographics, sources and outcomes of methanol poisoning have not been described in Turkey. Our study identified the profile of acute methanol exposures reported to Drug and Poison Information Center (DPIC) in Izmir, Turkey, from 1993 to 2002. Data analysis included patient demographics, sources of methanol, reason for the exposure, clinical effects and outcomes of methanol poisoning. The DPIC recorded 30,485 calls concerning poisoning; 996 (3.3%) alcohol poisonings were recorded and 113 (11.3%) of them were methanol poisonings. There were 91 (80.5%) males and 22 (19.5%) females with a mean age of 34.7+/-1.3 y (range 19-65) and 4.8+/-0.9 y (range 1-18) in adults and children, respectively. The sources of methanol were eu de cologne (72.6%), spirits (10.6%) and antifreeze (2.7%). Accidental poisoning occurred in all children between 0 and 12 y old, abuse (55.7%) and intentional poisoning (27.3%) were predominant in adults. Clinical signs in all cases were central nervous system symptoms (45.1%), metabolic acidosis (23.0%), visual symptoms (21.2%) and gastrointestinal symptoms (10.6%). Sixteen patients (14.1%) died, 63 (55.8%) had complete recovery and 1 (0.9%) had irreversible visual problems. Most patients with methanol poisoning may die or present serious morbidity without appropriate treatment in a health care facility. Methanol for producing cheap "eu de colognes" in Turkey is the principal reason for severe poisoning and deaths. Public education about colognes and legislative control of cologne production are important in preventing methanol poisoning.
Kalkan
Sule
S
Department of Pharmacology, Dokuz Eylul University School of Medicine, Izmir, Turkey.
Cevik
Arif Alper
AA
Cavdar
Caner
C
Aygoren
Oguz
O
Akgun
Aylin
A
Ergun
Nurdan
N
Tuncok
Yesim
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000175:diagnosis / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D004638:Emergency Treatment; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008499:Medical Records; D000432:Methanol / Q000506:poisoning*; D008875:Middle Aged; D011039:Poison Control Centers / Q000706:statistics & numerical data; D011041:Poisoning / Q000453:epidemiology / Q000209:etiology / Q000401:mortality / Q000517:prevention & control; D012189:Retrospective Studies; D019966:Substance-Related Disorders; D013406:Suicide, Attempted; D014057:Tomography, X-Ray Computed; D014421:Turkey / Q000453:epidemiology
D000432:Methanol