title: Effect of hypothalamic proline-rich-polypeptide on voltage-gated Ca2+ currents in retinal ganglion cells.
abstract: Neurotrophins are molecules that regulate neuronal survival, nervous system plasticity, and many other physiological functions of neuronal and glial cells. Here we studied the physiological action of a novel neurosecretory polypeptide proline-rich polypeptide (PRP), isolated from bovine neurohypophysis neurosecretory granules, on voltage-gated Ca currents and spike firing activity of retinal ganglion cells. PRP reversibly increased high voltage-activated L-type Ca current, but was without effect on low voltage-activated T-type current. PRP also increased the spike after hyperpolarization and reduced the frequency of spike firing, most likely by affecting a Ca-dependent potassium current.
authors.affiliation: Department of Ophthalmology, New York University School of Medicine, New York, New York 10016, USA. aa3@nyu.edu
authors.forename: Abram
authors.initials: A
authors.lastname: Akopian
authors.forename: Armen
authors.initials: A
authors.lastname: Galoyan
mesh_terms: D000200:Action Potentials; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism* / Q000502:physiology; D007031:Hypothalamus / Q000378:metabolism*; D015640:Ion Channel Gating; D010455:Peptides / Q000378:metabolism*; D055232:Proline-Rich Protein Domains; D012165:Retinal Ganglion Cells / Q000166:cytology / Q000378:metabolism*; D014562:Caudata
chemical_list: D015220:Calcium Channels; D010455:Peptides