1,3-dihydrobenzo[c]furan nucleoside analogues: additional studies of the thymine derivative.
The detailed study of the 1,3-dihydrobenzo[c]furan derivative of thymine is reported. The lack of anti-HIV activity of this compound in cell culture experiments is shown to be related to the inability of the corresponding 5'-triphosphate derivative to interact efficiently with the reverse transcriptase.
Egron
David
D
UMR 5625 CNRS-UM II, Université Montpellier II, cc 008, place E. Bataillon, 34095 Cedex 5, Montpellier, France.
Périgaud
Christian
C
Gosselin
Gilles
G
Aubertin
Anne-Marie
AM
Faraj
Abdesslem
A
Sélouane
Majid
M
Postel
Denis
D
Len
Christophe
C
D019380:Anti-HIV Agents / Q000737:chemistry; D001572:Benzofurans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006207:Half-Life; D006863:Hydrogen-Ion Concentration; D009705:Nucleosides; D018119:Stavudine / Q000737:chemistry; D013329:Structure-Activity Relationship; D013941:Thymine / Q000031:analogs & derivatives*
D019380:Anti-HIV Agents; D001572:Benzofurans; D009705:Nucleosides; D018119:Stavudine; D013941:Thymine