Clinical application of a hemoglobin-based oxygen-carrying solution.
Oxyglobin, a hemoglobin-based oxygen-carrying fluid, is indicated in the treatment of anemia in dogs and may be life saving if compatible red blood cells are not available for transfusion. The colloidal properties of Oxyglobin allow for expansion of the circulatory volume, which may be helpful in patients with hypovolemia, especially hemorrhagic shock. Oxyglobin's colloidal properties can also lead to circulatory overload, with development of pulmonary edema and pleural effusion, however, necessitating careful monitoring of the rate of administration and of the respiratory rate and effort of the patient. Measurement of total or plasma hemoglobin concentration can be used as an aid in monitoring patients receiving Oxyglobin.
Callan
Mary Beth
MB
Ryan Veterinary Hospital of the University of Pennsylvania, School of Veterinary Medicine, Philadelphia, 3900 Delancey Street, Philadelphia, PA 19104-6010, USA. callan@mail.vet.upenn.edu
Rentko
Virginia T
VT
D000818:Animals; D001802:Blood Substitutes / Q000009:adverse effects / Q000627:therapeutic use*; D002371:Cat Diseases / Q000628:therapy*; D002415:Cats; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D005260:Female; D006454:Hemoglobins / Q000009:adverse effects / Q000627:therapeutic use*; D010100:Oxygen / Q000097:blood; D012771:Shock, Hemorrhagic / Q000628:therapy / Q000662:veterinary*
D001802:Blood Substitutes; D006454:Hemoglobins; D010100:Oxygen