title: Vasodilatory activity in horsefly and deerfly salivary glands.
abstract: Salivary gland extract (SGE) of four horsefly species (Hybomitra bimaculata Macquart, Hybomitra ciureai Séguy, Tabanus bromius L., Tabanus glaucopis Meigen) and one deerfly species (Chrysops relictus Meigen) (Diptera: Tabanidae) were shown to contain vasodilatory activity. Aliquots equivalent to 1, 5 and 10 pairs of salivary glands (SG) relaxed rat femoral artery (with intact endothelium) pre-constricted with phenylephrine. Vasodilatory activity was dose-dependent. SGE of one horsefly species (Haematopota pluvialis L.) did not induce relaxation. The kinetics of vasodilation induced by SGE of four horsefly species differed from the deerfly. These results indicate that tabanid species may produce more than one type of vasodilator to aid blood feeding.
authors.affiliation: Institute of Zoology, Slovak Academy of Sciences, Bratislava, Slovakia.
authors.forename: P
authors.initials: P
authors.lastname: Rajská
authors.forename: O
authors.initials: O
authors.lastname: Pechánová
authors.forename: P
authors.initials: P
authors.lastname: Takác
authors.forename: M
authors.initials: M
authors.lastname: Kazimírová
authors.forename: L
authors.initials: L
authors.lastname: Roller
authors.forename: L
authors.initials: L
authors.lastname: Vidlicka
authors.forename: F
authors.initials: F
authors.lastname: Ciampor
authors.forename: M
authors.initials: M
authors.lastname: Labuda
authors.forename: P A
authors.initials: PA
authors.lastname: Nuttall
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects / Q000662:veterinary; D004175:Diptera / Q000737:chemistry* / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D005263:Femoral Artery / Q000187:drug effects; D006790:Host-Parasite Interactions; D007700:Kinetics; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012469:Salivary Glands / Q000737:chemistry*; D013045:Species Specificity; D014020:Tissue Extracts / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D014020:Tissue Extracts; D014665:Vasodilator Agents