title: Experimental study of a porous rat tracheal prosthesis made of T40: long-term survival analysis.
abstract: In order to repair large defects in the laryngotracheal area, we developed a biomaterial based on porous titanium (Ti40) formed of spherical particles that are welded together. These Ti40 beads were arranged in several layers to create the rat tracheal prosthesis. After a partial tracheal resection, the prosthesis was fixed to both extremities to replace the missing part. Tissue surrounding the prosthesis was collected from 33 surviving animals after an implantation period of 3 to 12 months. Histological analyses showed that the periphery of the prosthesis was covered with fibroblasts and a few lymphocytes that penetrated the titanium layers. A ciliary cylindrical epithelium of respiratory type was found on the endoluminal side. The inflammatory reaction observed was minimal. These data indicate that the prosthesis, implanted in a laryngotracheal environment, is well tolerated by animals. Our results represent the first step towards the construction of a total laryngeal prosthesis that should allow restoration of the essential functions of the larynx after a laryngectomy in cancer treatment.
authors.affiliation: Department of Otorhinoaryngology, CHU Hautepierre, avenue Molière, 67098, Strasbourg, France. philippe.schultz@chru-strasbourg.fr
authors.forename: P
authors.initials: P
authors.lastname: Schultz
authors.forename: D
authors.initials: D
authors.lastname: Vautier
authors.forename: C
authors.initials: C
authors.lastname: Egles
authors.forename: C
authors.initials: C
authors.lastname: Debry
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001705:Bioprosthesis; D004947:Esophagus / Q000473:pathology / Q000601:surgery*; D008297:Male; D008422:Materials Testing; D023421:Models, Animal; D016062:Porosity; D011474:Prosthesis Design; D011475:Prosthesis Failure; D019919:Prosthesis Implantation; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013499:Surface Properties; D015996:Survival Rate; D014025:Titanium
chemical_list: D001672:Biocompatible Materials; D014025:Titanium