title: Intranuclear inclusions in a case of pigmented villonodular synovitis of the ankle.
abstract: Pigmented villonodular synovitis (PVNS) is a proliferative disorder of the synovial lining of the joints. Although the cytological findings of this disorder have been described in the literature, there is no mention of intranuclear cytoplasmic inclusions in this entity. A 65-yr-old woman presented with a painful swelling on the ankle. In addition to other characteristic findings of PVNS, we found the presence of intranuclear cytoplasmic inclusions in the fine-needle aspiration (FNA) smears. The characteristic cytological findings of abundant mononuclear cells occurring singly and in papillary clusters, multinucleated giant cells, and hemosiderin deposition should aid in the diagnosis of PVNS and in its differentiation from melanoma and other soft tissue sarcomas, even in the presence of uncommon features such as intranuclear inclusions.
authors.affiliation: Department of Pathology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Wardha 442102 Maharashtra, India. nitingangane@rediffmail.com
authors.forename: Nitin
authors.initials: N
authors.lastname: Gangane
authors.lastname: Anshu
authors.forename: V B
authors.initials: VB
authors.lastname: Shivkumar
authors.forename: S M
authors.initials: SM
authors.lastname: Sharma
mesh_terms: D000368:Aged; D000843:Ankle Joint / Q000378:metabolism / Q000473:pathology*; D015415:Biomarkers / Q000032:analysis; D044963:Biopsy, Fine-Needle; D003937:Diagnosis, Differential; D005260:Female; D015726:Giant Cells / Q000378:metabolism / Q000473:pathology; D006485:Hemosiderin / Q000378:metabolism; D006801:Humans; D045586:Intranuclear Inclusion Bodies / Q000473:pathology*; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000473:pathology; D008545:Melanoma / Q000175:diagnosis / Q000378:metabolism; D012509:Sarcoma / Q000175:diagnosis / Q000378:metabolism; D012878:Skin Neoplasms / Q000175:diagnosis / Q000378:metabolism; D012983:Soft Tissue Neoplasms / Q000175:diagnosis / Q000378:metabolism; D013583:Synovial Membrane / Q000378:metabolism / Q000473:pathology*; D013586:Synovitis, Pigmented Villonodular / Q000378:metabolism / Q000473:pathology*
chemical_list: D015415:Biomarkers; D006485:Hemosiderin