[Study of pharmacological activity of complex magnesium-containing preparation based on mineral bishofit and pyridoxine hydrochloride in a rat model of chronic alcoholic intoxication].
Nervous disturbances accompanying alcoholic illness were studied in relation to the depletion of magnesium ion content in the organism. The possibility of correcting the development of psychic (behavioral) pathologies by treatment with a complex magnesium-containing preparation based on mineral bishofit and pyridoxine hydrochloride (below, Mg-containing preparation) was studied in rats upon three-month voluntary alcoholization. A decrease in the locomotor (number of crossed squares) and vertical (number of standings) activity as evaluated in the open-field test and an increase in the immobilization time in the forced swim test showed evidence of depressive state in animals after long-term ethanol administration. After treatment with the Mg-containing preparation (50 mg Mg/kg in 2.5 ml volume, p.o.), the immobilization time of alcohol-preferring rats decreased in comparison to that before treatment and showed no statistically significant differences from the value in the intact control group. A decrease in the immobilization time (the main sign of antidepressant action) allows the Mg-containing preparation to be considered as antidepressant. The level of magnesium in rat blood erythrocytes decreased upon three-month voluntary alcoholization by 40.95 +/- 2.41% relative to control (p < 0.05). After a 5-week treatment with Mg-containing preparation under conditions of free access to alcohol, the content of magnesium in the erythrocytes of alcohol-preferring rats restored on a normal level. Chronic alcoholism reduces the content of microelements and vitamins (in particular, B6), these changes being mutually related.
Spasov
A A
AA
Pharmacology Department, Volgograd State Medical Academy, pl. Pavshikh Bortsov 1a, Volgograd, 400066, Russia. Farm@interda-com.ru
Petrov
V I
VI
Iezhitsa
I N
IN
Onishchenko
N V
NV
Churbakova
N V
NV
Parshev
V V
VV
D000437:Alcoholism / Q000097:blood / Q000150:complications* / Q000503:physiopathology / Q000523:psychology; D000818:Animals; D003863:Depression / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D004338:Drug Combinations; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005106:Exploratory Behavior / Q000187:drug effects; D005260:Female; D008274:Magnesium / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008903:Minerals / Q000737:chemistry; D009043:Motor Activity / Q000187:drug effects; D011736:Pyridoxine / Q000494:pharmacology*; D051381:Rats; D013550:Swimming; D014149:Tranquilizing Agents / Q000494:pharmacology*
D004338:Drug Combinations; D008903:Minerals; D014149:Tranquilizing Agents; D008274:Magnesium; D011736:Pyridoxine