title: Blood coagulation factor VIII: An overview.
abstract: Factor VIII (FVIII) functions as a co-factor in the blood coagulation cascade for the proteolytic activation of factor X by factor IXa. Deficiency of FVIII causes hemophilia A, the most commonly inherited bleeding disorder. This review highlights current knowledge on selected aspects of FVIII in which both the scientist and the clinician should be interested.
authors.affiliation: Research and Development Division, Hindustan Antibiotics Ltd, Pimpri, Pune 411 018, India. girishbhopale@rediffmail.com
authors.forename: G M
authors.initials: GM
authors.lastname: Bhopale
authors.forename: R K
authors.initials: RK
authors.lastname: Nanda
mesh_terms: D005169:Factor VIII / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use; D006467:Hemophilia A / Q000188:drug therapy / Q000235:genetics; D006801:Humans; D009154:Mutation
chemical_list: D005169:Factor VIII