title: Antibody-directed enzyme-prodrug therapy.
authors.affiliation: Cancer Research UK Targeting and Imaging Group, Department of Oncology, Royal Free and University College Medical School, London, UK.
authors.forename: R Barbara
authors.initials: RB
authors.lastname: Pedley
authors.forename: Surinder K
authors.initials: SK
authors.lastname: Sharma
authors.forename: Robert E
authors.initials: RE
authors.lastname: Hawkins
authors.forename: Kerry A
authors.initials: KA
authors.lastname: Chester
mesh_terms: D000818:Animals; D000906:Antibodies / Q000235:genetics* / Q000627:therapeutic use; D000951:Antigens, Neoplasm / Q000276:immunology; D001483:Base Sequence; D017931:DNA Primers; D004798:Enzymes / Q000235:genetics*; D005818:Genetic Engineering / Q000379:methods; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D008727:Methotrexate / Q000493:pharmacokinetics / Q000627:therapeutic use; D051379:Mice; D008954:Models, Biological; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D016133:Polymerase Chain Reaction / Q000379:methods; D011355:Prodrugs / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011623:gamma-Glutamyl Hydrolase / Q000235:genetics / Q000378:metabolism
chemical_list: D000906:Antibodies; D000951:Antigens, Neoplasm; D017931:DNA Primers; D004798:Enzymes; D011355:Prodrugs; D011623:gamma-Glutamyl Hydrolase; D008727:Methotrexate