title: Chronomics: circadian and circaseptan timing of radiotherapy, drugs, calories, perhaps nutriceuticals and beyond.
abstract: We suggest a putative benefit from timing nutriceuticals (substances that are both nutrients and pharmaceuticals) such as antioxidants for preventive or curative health care, based on the proven merits of timing nutrients, drugs, and other treatments, as documented, i.a., in India. The necessity of timing melatonin, a major antioxidant, is noted. A protocol to extend the scope of chronoradiotherapy awaits testing. Imaging in time by mapping rhythms and broader time structures, chronomes, for earliest diagnoses, for example detection of vascular disease risk, is recommended. The study of rhythms and broader chronomes leads to a dynamic functional genomics, guided by imaging in time of free radicals and antioxidants, amongst many other variables.
authors.affiliation: University of Minnesota, Minneapolis, MN, USA.
authors.forename: Franz
authors.initials: F
authors.lastname: Halberg
authors.forename: Germaine
authors.initials: G
authors.lastname: Cornélissen
authors.forename: Zhengrong
authors.initials: Z
authors.lastname: Wang
authors.forename: Chaomin
authors.initials: C
authors.lastname: Wan
authors.forename: Waldemar
authors.initials: W
authors.lastname: Ulmer
authors.forename: George
authors.initials: G
authors.lastname: Katinas
authors.forename: Ranjana
authors.initials: R
authors.lastname: Singh
authors.forename: R K
authors.initials: RK
authors.lastname: Singh
authors.forename: Rajesh Kumar
authors.initials: RK
authors.lastname: Singh
authors.forename: B D
authors.initials: BD
authors.lastname: Gupta
authors.forename: R B
authors.initials: RB
authors.lastname: Singh
authors.forename: Adarsh
authors.initials: A
authors.lastname: Kumar
authors.forename: Eugene
authors.initials: E
authors.lastname: Kanabrocki
authors.forename: Robert B
authors.initials: RB
authors.lastname: Sothern
authors.forename: Gundu
authors.initials: G
authors.lastname: Rao
authors.forename: Madan L B
authors.initials: ML
authors.lastname: Bhatt
authors.forename: Madhu
authors.initials: M
authors.lastname: Srivastava
authors.forename: Gulshan
authors.initials: G
authors.lastname: Rai
authors.forename: Subhash
authors.initials: S
authors.lastname: Singh
authors.forename: Atanu Kumar
authors.initials: AK
authors.lastname: Pati
authors.forename: Panchanan
authors.initials: P
authors.lastname: Nath
authors.forename: Francine
authors.initials: F
authors.lastname: Halberg
authors.forename: Julia
authors.initials: J
authors.lastname: Halberg
authors.forename: Othild
authors.initials: O
authors.lastname: Schwartzkopff
authors.forename: Earl
authors.initials: E
authors.lastname: Bakken
authors.lastname: Governor Shri Vishnu Kant Shastri
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002909:Chronobiology Phenomena / Q000502:physiology*; D019454:Chronotherapy / Q000379:methods; D002940:Circadian Rhythm / Q000502:physiology*; D002149:Energy Intake / Q000502:physiology*; D006801:Humans; D008550:Melatonin / Q000502:physiology; D009747:Nutritional Physiological Phenomena / Q000502:physiology*; D018714:Radiotherapy, Adjuvant
chemical_list: D000970:Antineoplastic Agents; D008550:Melatonin