Unchanged striatal dopamine transporter availability in narcolepsy: a PET study with [11C]-CFT.
OBJECTIVE
To investigate dopamine reuptake sites (dopamine transporter) in the caudate nucleus and putamen in narcolepsy.


METHODS
Ten patients with narcolepsy and 15 controls were studied with positron emission tomography. A cocaine analogue [11C]-CFT was used as a radioligand.


RESULTS
The uptake of[11C]-CFT was within normal limits (89% of age-adjusted control mean in the caudate nucleus and 91% in the putamen) in patients with narcolepsy.


CONCLUSIONS
No evidence of altered striataldopamine transporter availability was found in narcolepsy.
Rinne
J O
JO
Turku PET-Centre, University of Turku, Turku, Finland. juha.rinne@pet.tyks.fi
Hublin
C
C
Någren
K
K
Helenius
H
H
Partinen
M
M
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002421:Caudate Nucleus / Q000473:pathology* / Q000502:physiology; D003042:Cocaine / Q000031:analogs & derivatives*; D050483:Dopamine Plasma Membrane Transport Proteins; D018765:Dopamine Uptake Inhibitors; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000502:physiology*; D008875:Middle Aged; D009290:Narcolepsy / Q000503:physiopathology*; D009419:Nerve Tissue Proteins; D011699:Putamen / Q000473:pathology* / Q000502:physiology; D014055:Tomography, Emission-Computed
D050483:Dopamine Plasma Membrane Transport Proteins; D018765:Dopamine Uptake Inhibitors; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C021279:(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester; D003042:Cocaine