Running into problems: how cells cope with replicating damaged DNA.
The ability of cells to fully and faithfully replicate DNA is essential for preventing genomic instability and cancer. DNA is susceptible to damage both in resting and in actively replicating cells. Thus, genome duplication necessarily involves replication of damaged DNA. The many mechanism cells use to avoid or overcome the problems of replicating an imperfect DNA template are discussed.
McGowan
Clare H
CH
Department of Molecular Biology and Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. chmcg@scripps.edu
D000818:Animals; D004249:DNA Damage; D004260:DNA Repair / Q000502:physiology*; D004261:DNA Replication / Q000502:physiology*; D005057:Eukaryotic Cells / Q000502:physiology; D006801:Humans; D011387:Prokaryotic Cells / Q000502:physiology; D011995:Recombination, Genetic