title: Stereostructure of komodoquinone A, a neuritogenic anthracycline, from marine Streptomyces sp. KS3.
abstract: The absolute stereostructure of komodoquinone A (1), a neuritogenic anthracycline, which was isolated from a cultured marine Streptomyces sp. KS3, has been determined on the basis of chemical derivatization. Komodoquinone A (1) induces neuronal cell differentiation in the neuroblastoma cell line, Neuro 2A and arrests the cell cycle at the G1 phase. The effect of a solid-state medium on the production of 1 and its aglycone, komodoquinone B (2), was examined.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
authors.forename: Takuya
authors.initials: T
authors.lastname: Itoh
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kinoshita
authors.forename: Hong
authors.initials: H
authors.lastname: Wei
authors.forename: Motomasa
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D018943:Anthracyclines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000880:Anthraquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology; D045744:Cell Line, Tumor; D005285:Fermentation; D051379:Mice; D012623:Seawater / Q000382:microbiology; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry* / Q000254:growth & development
chemical_list: D018943:Anthracyclines; D000880:Anthraquinones; C481241:komodoquinone A