[Characteristic changes of acetylcholine receptor in rat lateral pterygoid muscles after functional mandibule advancement].
OBJECTIVE
The purpose of this study was to evaluate the maximum binding(Bmax) and affinity(Kd value) changes of acetylcholine receptor (n-AchR) in rat lateral pterygoid muscles after functional mandibule advancement.


METHODS
40 five-weeks-old male Sprague-Dawley rats were equally divided into experimental and control group. The mimic functional appliances were used in experiment group and the rats were killed after 1, 3, 7, 14 days. Radio-ligand binding assay (RBA) was applied to determine the maximum binding(Bmax) and Kd value of n-AchR of lateral pterygoid muscle.


RESULTS
The Bmax of n-AchR in experimental group was higher than that in control group and the Kd value always kept in high level.


CONCLUSIONS
The functional orthopedics can increase the Bmax of n-AchR in rapid growing rat lateral pterygoid muscles.
Chen
Kaiyun
K
Department of Orthodontics, Oral Hospital of Guangdong Province, Guangzhou 510280, China.
Luo
Songjiao
S
D000818:Animals; D001665:Binding Sites; D002462:Cell Membrane / Q000378:metabolism; D008297:Male; D019186:Mandibular Advancement; D017289:Orthodontic Appliances, Functional; D011626:Pterygoid Muscles / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011950:Receptors, Cholinergic / Q000378:metabolism*
D011950:Receptors, Cholinergic