Monitoring of radiation-induced germline mutation in humans.
Estimating the genetic hazards of radiation and other mutagens in humans depends on extrapolation from experimental systems. Recent data have shown that minisatellite loci provide a useful and sensitive experimental approach for monitoring radiation-induced mutation in humans. This review describes the progress made in validating this approach and presents the results of recent publications on the analysis of minisatellite mutation rates in the irradiated families.
Dubrova
Yuri E
YE
Department of Genetics, University of Leicester, United Kingdom. yed2@le.ac.uk
D000016:Abnormalities, Radiation-Induced / Q000235:genetics; D015331:Cohort Studies; D004276:DNA, Satellite / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005854:Germ Cells / Q000528:radiation effects*; D018095:Germ-Line Mutation / Q000235:genetics / Q000528:radiation effects*; D006801:Humans; D018598:Minisatellite Repeats / Q000235:genetics / Q000528:radiation effects*; D011839:Radiation, Ionizing; D018788:Radioactive Hazard Release; D002094:Republic of Belarus; D014455:Ukraine
D004276:DNA, Satellite