Septic arthritis as the first sign of Candida tropicalis fungaemia in an acute lymphoid leukemia patient.
Fungal infections caused by Candida species have increased in incidence during the past two decades in England, North America and Europe. Candidal arthritis is rare in patients who are not intravenous drug users or are who not using a prostheses. We report the case of a 24-year-old man with acute lymphoid leukemia, who developed Candida tropicalis arthritis during an aplastic period after chemotherapy. This is the eighth case described in the literature of C. tropicalis causing arthritis without intra-articular inoculation. We call attention to an unusual first sign of fungal infection: septic arthritis without intra-articular inoculation. However, this case differs from the other seven, since despite therapy a fast and lethal evolution was observed. We reviewed reported cases, incidence, risk factors, mortality and treatment of neutropenic patients with fungal infections.
Vicari
Perla
P
Federal University of São Paulo, SP, Brazil.
Feitosa Pinheiro
Ronald
R
Chauffaille
Maria de Lourdes Lopes Ferrari
Mde L
Yamamoto
Mihoko
M
Figueiredo
Maria Stella
MS
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000188:drug therapy / Q000382:microbiology*; D041022:Candida tropicalis / Q000302:isolation & purification*; D017809:Fatal Outcome; D016469:Fungemia / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000382:microbiology
D000935:Antifungal Agents; D000666:Amphotericin B