title: Observational study on the efficacy of tibolone in counteracting early carotid atherosclerotic lesions in postmenopausal women.
abstract: OBJECTIVE
  To study whether tibolone affects lipid profile and diffused intima media thickness (IMT) of the common carotid arteries (CCA) in postmenopausal women (PMW).
  
  
  METHODS
  Twenty-two PMW and 20 premenopausal women participated in the study. The PMW were randomly divided into 11 women who did not receive any treatment and 11 women who received tibolone (2.5 mg once a day).
  
  
  RESULTS
  After 6 months the treated women had lipoprotein(a) (Lpa), total-cholesterol (total-C), and LDL-cholesterol (LDL-C) levels lower than before, while in the non-treated women Lpa was increased. The IMT of CCA was unmodified in the treated women, whereas it increased in non-treated women.
  
  
  CONCLUSIONS
  This preliminary study suggests that a 6-month tibolone treatment could counteract the increase of the IMT of CCA observed in untreated PMW.
authors.affiliation: Department of Internal Medical Sciences, University of Cagliari, Cagliari, Italy.
authors.forename: Francesca Maria
authors.initials: FM
authors.lastname: Anedda
authors.forename: Andrea
authors.initials: A
authors.lastname: Velati
authors.forename: Stefano
authors.initials: S
authors.lastname: Lello
authors.forename: Marisa
authors.initials: M
authors.lastname: Orrù
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Paoletti
authors.forename: Gian Benedetto
authors.initials: GB
authors.lastname: Melis
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Binaghi
mesh_terms: D000328:Adult; D016893:Carotid Stenosis / Q000097:blood / Q000473:pathology*; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D020847:Estrogen Receptor Modulators / Q000494:pharmacology*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood; D008875:Middle Aged; D009652:Norpregnenes / Q000494:pharmacology*; D017698:Postmenopause / Q000097:blood / Q000187:drug effects*; D017539:Tunica Intima / Q000187:drug effects* / Q000473:pathology
chemical_list: D008078:Cholesterol, LDL; D020847:Estrogen Receptor Modulators; D017270:Lipoprotein(a); D009652:Norpregnenes; D002784:Cholesterol; C027385:tibolone