title: [Celecoxib in NSAID-induced cutaneous and respiratory adverse reactions].
abstract: OBJECTIVE
  Inhibition of COX-1 appears to be a key event in most non-steroidal anti-inflammatory drugs (NSAIDs)-induced adverse reactions. We evaluated celecoxib tolerance, a highly specific COX-2 inhibitor, in NSAIDs-sensitive patients.
  
  
  METHODS
  Intolerant patients were challenged in a single-blind study with placebo and celecoxib (increasing doses up to 400 mg).
  
  
  RESULTS
  We included 59 patients (41 women): 34 with urticaria with or without angiodema, 21 with bronchospasm, and 4 with urticaria and bronchospasm. Only two patients on celecoxib developed urticaria (3.4%).
  
  
  CONCLUSIONS
  Celecoxib is well tolerated by most NSAIDs-intolerant patients and can be a safe alternative when analgesic or antiinflammatory therapy is indicated.
authors.affiliation: Servicio de Neumología y Alergia Respiratoria. Hospital Clínic. Barcelona. Spain. cpicado@medicina.ub.es
authors.forename: Antonio
authors.initials: A
authors.lastname: Valero
authors.forename: Ernesto
authors.initials: E
authors.lastname: Enrique
authors.forename: Miquel
authors.initials: M
authors.lastname: Baltasar
authors.forename: Ana
authors.initials: A
authors.lastname: Cisteró
authors.forename: Enrique
authors.initials: E
authors.lastname: Martí
authors.forename: César
authors.initials: C
authors.lastname: Picado
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D003875:Drug Eruptions / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011720:Pyrazoles; D012130:Respiratory Hypersensitivity / Q000139:chemically induced* / Q000188:drug therapy*; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib