Microtubule-associated protein 2 (MAP2) expression during synaptic plasticity in the guinea pig cochlea.
The expression of different isoforms of microtubule-associated proteins 2 (MAP2), including the low molecular weight form MAP2c present mainly in developing neurons, was investigated in the primary auditory neurons after alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) perfusion in the guinea pig cochlea. MAP2 expression appeared to be tightly regulated in the repairing neurons. Neurite regrowth seems to involve the MAP2c isoform. In cochlear neurons, mechanisms involved in the period of development might be reactivated after excitotoxic injury in the mature cochlea.
Ladrech
Sabine
S
INSERM U583 et Universités Montpellier I et II, Physiopathologie et Thérapie des Déficits Sensoriels et Moteurs, 71, rue de Navacelles, 34090 Montpellier, France.
Lenoir
Marc
M
Ruel
Jérôme
J
Puel
Jean-Luc
JL
D000200:Action Potentials; D000818:Animals; D003051:Cochlea / Q000502:physiology*; D003055:Cochlear Microphonic Potentials / Q000502:physiology; D018690:Excitatory Amino Acid Agonists / Q000633:toxicity; D005260:Female; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008970:Molecular Weight; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D013569:Synapses / Q000502:physiology*; D000159:Vestibulocochlear Nerve / Q000378:metabolism*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000633:toxicity
D018690:Excitatory Amino Acid Agonists; D008869:Microtubule-Associated Proteins; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid