Recent advances in enantioseparations of peptides by capillary electrophoresis.
The present review summarizes peptide enantioseparations by capillary electrophoresis with the focus on recent developments. These include the application of new chiral selectors and systematic studies involving series of di- and tripeptides with either common features or with a variety of structures. One section emphasizes mechanistic aspects of the migration order of the enantiomers in cyclodextrin-assisted chiral separations with respect to the complexation constants and the mobilities of the transient diastereomeric complexes. In addition, short paragraphs on the application of chiral capillary electrophoresis to the determination of the stereochemical purity of peptidomimetics and on chiral separations of peptides by capillary electrochromatography have also been included.
Scriba
Gerhard K E
GK
University of Jena, School of Pharmacy, Department of Pharmaceutical Chemistry, Jena, Germany. gerhard.scriba@uni-jena.de
D003505:Cyclodextrins / Q000737:chemistry*; D004151:Dipeptides / Q000032:analysis*; D019075:Electrophoresis, Capillary
D003505:Cyclodextrins; D004151:Dipeptides