[Effect of modulator of the signal transmission from opioid receptor to sodium channels on hypothalamus self-stimulation].
We investigated effects of different doses of a new preparation comenic acid as a modulator of the transmission of signals from an opioid receptor to slow sodium channels on the hypothalamic rewarding system in male Wistar rats. Comenic acid has been shown to inhibit the reaction of the hypothalamic self-stimulation (SS) in a dose-dependent fashion with the strongest effect at doses of 28.8-30 mg/kg. We observed a decrease in the rate of lever-pressings, induced by the threshold for SS current intensity, and an increase in the threshold for the response of SS, or its cessation. The similar suppressing effect of the preparation was found at its repeated injections. Thus, those results showed that comenic acid failed in both activation of the rewarding system of the lateral hypothalamus and adaptation to it.
Butkevich
I P
IP
I.P. Pavlov Institute of Physiology, RAN, St. Petersburg, Donetsk Medical University.
Mikhaĭlenko
V A
VA
Krylov
B V
BV
Kazakov
V N
VN
Panova
T I
TI
Otellin
V A
VA
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D004566:Electrodes; D007026:Hypothalamic Area, Lateral / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D008297:Male; D011753:Pyrones / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000378:metabolism / Q000502:physiology*; D012653:Self Stimulation / Q000187:drug effects*; D015222:Sodium Channels / Q000378:metabolism / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
D011753:Pyrones; D011957:Receptors, Opioid; D015222:Sodium Channels