title: In vitro antigiardial activity of IRE-6A and IRE-7B, two ethyl-phenylcarbamate derivatives.
abstract: Resistance is a practical problem associated to the use of benzimidazoles in the antigiardial therapy. Since benzimidazole-resistant strains of fungi have shown increased sensitivity to phenylcarbamates, in this study we synthesized and in vitro tested novel substituted phenylcarbamates against the protozoa Giardia intestinalis. IRE-6A and IRE-7B, two 4-R-ethyl-phenylcarbamates demonstrated an important antigiardial activity although that was modest when compared to albendazole in axenic cultures of Giardia intestinalis. Results of this study suggest a potential role of phenylcarbamates as alternative to benzimidazoles in the therapy of giardiasis.
authors.affiliation: Hospital Infantil de México, SSA.
authors.forename: Enedina
authors.initials: E
authors.lastname: Jiménez-Cardoso
authors.forename: Andrés
authors.initials: A
authors.lastname: Flores-Luna
authors.forename: E
authors.initials: E
authors.lastname: Angeles
authors.forename: P
authors.initials: P
authors.lastname: Martínez
authors.forename: R
authors.initials: R
authors.lastname: López-Castañares
authors.forename: G
authors.initials: G
authors.lastname: Castañeda-Hernández
authors.forename: José
authors.initials: J
authors.lastname: Pérez-Urizar
mesh_terms: D015766:Albendazole / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002219:Carbamates / Q000494:pharmacology*; D016829:Giardia lamblia / Q000187:drug effects*
chemical_list: D000981:Antiprotozoal Agents; D002219:Carbamates; C481945:IRE-6A; C481946:IRE-7B; D015766:Albendazole