title: Research on infectious bursal disease--the past, the present and the future.
abstract: Infectious bursal disease (IBD) virus (IBDV) is the etiological agent of "Gumboro disease". Although first observed about 40 years ago, this disease continues to pose an important threat to the commercial poultry industry. The emergence of antigenic variant as well as very virulent strains in vaccinated flocks considerably stimulated research efforts on both, IBD and IBDV. In this review, some of the recent advances in the understanding of the structure, morphogenesis and molecular biology of the virus as well as in development of new diagnostic approaches and new strategies for vaccination against IBD are briefly summarized.
authors.affiliation: Institute for Virology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, D-04103 Leipzig, Germany. virology@vetmed.uni-leipzig.de
authors.forename: Hermann
authors.initials: H
authors.lastname: Müller
authors.forename: Md Rafiqul
authors.initials: MR
authors.lastname: Islam
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Raue
mesh_terms: D000818:Animals; D018175:Birnaviridae Infections / Q000276:immunology / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D002645:Chickens; D007243:Infectious bursal disease virus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D011201:Poultry Diseases / Q000276:immunology / Q000473:pathology / Q000821:virology*; D014611:Vaccination / Q000662:veterinary; D014613:Vaccines, Attenuated / Q000276:immunology / Q000592:standards; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines