Association between vitamin D receptor gene haplotypes and bone mass in postmenopausal Korean women.
OBJECTIVE
The objective of the study was to evaluate the effect of vitamin D receptor (VDR) gene haplotypes on bone mineral density (BMD).


METHODS
The VDR Bsm I, Apa I, Taq I, and poly(A) polymorphisms were analyzed in 417 postmenopausal Korean women. Serum 1,25(OH)(2) vitamin D(3), osteocalcin, bone alkaline phosphatase, and CrossLaps were measured by immunoradiometric assay and enzyme-linked immunosorbent assay. BMD at the lumbar spine and proximal femur was determined by dual-energy x-ray absorptiometry.


RESULTS
At all skeletal sites, genotypes not carrying the baTL haplotype allele (uppercase letters signifying the absence, lowercase letters the presence, of the restriction site, and L a repeat length of more than 17) had significantly lower BMD than baTL homozygotes. The former genotypes were more prevalent in women with low bone mass than in healthy women. No significant differences in vitamin D(3) or bone markers levels were noted among the baTL haplotype genotypes.


CONCLUSIONS
The VDR baTL haplotype allele is related to bone mass in Korean women.
Kim
Jung Gu
JG
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University Hospital, 28 Yeungun-dong Chongno-Ku, Seoul 110-744, Korea. kimjg@plaza.snu.ac.kr
Kwon
Jae Hee
JH
Kim
Seok Hyun
SH
Choi
Young Min
YM
Moon
Shin Yong
SY
Lee
Jin Yong
JY
D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D015519:Bone Density; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006720:Homozygote; D006801:Humans; D015810:Linkage Disequilibrium; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause / Q000502:physiology*; D018167:Receptors, Calcitriol / Q000235:genetics*; D012044:Regression Analysis
D018167:Receptors, Calcitriol