Determination of biguanide groups in polyhexamethylene biguanide hydrochloride by titrimetric methods.
The biguanide concentration of polyhexamethylene biguanide hydrochloride (PHMB-HCl) was measured by non-aqueous titration with HClO4, argentometric titration, the Kjeldhal method, and colloidal titration. The summation value of non-aqueous titration and argentometric titration corresponded to two titrable nitrogens in five nitrogens per one unit of PHMB-HCl, and consisted with the result of the Kjeldhal method to the five nitrogens. The colloidal titration of PHMB-HCl at pH 2.05 was equal to that with the two nitrogens. The relative standard deviations of non-aqueous titration, argentometric titration, the Kjeldhal method, and colloidal titration were 0.50% for 8 runs, 0.13% for 7 runs, 3.61% for 6 runs, and 0.69% for 6 runs, respectively.
Hattori
Toshiaki
T
Research Center for Chemometrics, Toyohashi University of Technology, Tempaku Hibarigaoka 1-1, Toyohashi 441-8580, Japan. hattori@tut3c.tut.ac.jp
Nakata
Yasuko
Y
Kato
Ryo
R
D001645:Biguanides / Q000032:analysis* / Q000737:chemistry*; D003102:Colloids / Q000737:chemistry; D004202:Disinfectants / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009584:Nitrogen / Q000032:analysis; D010472:Perchlorates / Q000737:chemistry; D011199:Potentiometry / Q000379:methods; D012835:Silver Nitrate / Q000737:chemistry; D017186:Titrimetry
D001645:Biguanides; D003102:Colloids; D004202:Disinfectants; D010472:Perchlorates; C031233:polihexanide; D012835:Silver Nitrate; D009584:Nitrogen