Cancer incidence among laboratory workers in biomedical research and routine laboratories in Israel: Part I-the cohort study.
BACKGROUND
Laboratory work is associated with exposure to a mixture of carcinogens.


METHODS
The cohort is comprised of 4,300 laboratory workers. Cancer incidence was followed from 1960 to 1997.


RESULTS
A total of 230 cases were included in the cohort. The overall cancer standardized incidence ratio (SIR) was 1.04 (0.91-1.18). When a 20-year latency was introduced, SIR was increased significantly: 1.35 (1.13-1.61). Among routine workers and researchers, SIR was elevated significantly for the total population and for women, when a 20-year latency was introduced. SIR was also elevated significantly in research, routine, bacteriology and virology, and isotope laboratories. With respect to specific sites, significantly increased SIR was observed in breast, ovary, and thyroid cancer among women; and prostate cancer, leukemia, and melanoma among men.


CONCLUSIONS
We suggest that work in research and biomedical laboratories might involve an increased risk of certain types of cancer. Am. J. Ind. Med. 44:600-610, 2003.
Shaham
Judith
J
Occupational Cancer Department, National Institute of Occupational & Environmental Health, Raanana, Israel. Judiths@ioh.org.il
Gurvich
Rachel
R
Kneshet
Yael
Y
D035843:Biomedical Research; D002274:Carcinogens, Environmental / Q000009:adverse effects*; D016000:Cluster Analysis; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008297:Male; D017056:Medical Laboratory Personnel; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology*
D002274:Carcinogens, Environmental