The clinical uses of leptin.
Leptin is the first of a group of adipocyte-secreted hormones to be used clinically to treat hypoleptinemic states. In children with congenital leptin deficiency and extreme obesity, leptin induces satiety and a dramatic loss of weight. In hypoleptinemic patients with extreme insulin resistance and lipodystrophy, leptin ameliorates insulin resistance, hyperglycemia, hyperinsulinemia, dyslipidemia and hepatic steatosis. In both these leptin-deficient states, leptin therapy restores gonadotrophin secretion, as well as luteinizing hormone and thyroid-stimulating hormone pulsitility.
Gorden
Phillip
P
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 8S-235S, Bethesda, MD 20892-1770, USA. PhillipG@intra.niddk.nih.gov
Gavrilova
Oksana
O
D000818:Animals; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007333:Insulin Resistance; D020738:Leptin / Q000172:deficiency / Q000627:therapeutic use*; D008060:Lipodystrophy / Q000188:drug therapy; D009765:Obesity / Q000188:drug therapy*; D010913:Pituitary-Adrenal System / Q000187:drug effects; D012527:Satiation / Q000187:drug effects; D015431:Weight Loss / Q000187:drug effects
D020738:Leptin