title: A randomized controlled trial of calcium with vitamin D, alone or in combination with intravenous pamidronate, for the treatment of low bone mineral density associated with Crohn's disease.
abstract: BACKGROUND
  Osteoporosis is a common complication of Crohn's disease.
  
  
  OBJECTIVE
  To study the effect on the bone mineral density of a bisphosphonate (pamidronate) given intravenously, in combination with oral calcium and vitamin D supplements, compared with oral calcium and vitamin D supplements alone.
  
  
  METHODS
  Seventy-four patients with Crohn's disease and low bone mineral density at the lumbar spine and/or hip were randomized to receive either a daily dose of 500 mg of calcium with 400 IU of vitamin D alone or in combination with four three-monthly infusions of 30 mg of intravenous pamidronate over the course of 12 months. The main outcome measure was the change in bone mineral density at the lumbar spine and hip, measured by dual X-ray absorptiometry, at baseline and 12 months.
  
  
  RESULTS
  Both groups gained bone mineral density at the lumbar spine and hip after 12 months. There were significant (P < 0.05) changes in the pamidronate group, with gains of + 2.6%[95% confidence interval (CI), 1.4-3.0] at the spine and + 1.6% (95% CI, 0.6-2.5) at the hip, compared with gains of + 1.6% (95% CI, - 0.1-3.2) and + 0.9% (95% CI, - 0.4-2.1) at the spine and hip, respectively, in the group taking vitamin D and calcium supplements alone.
  
  
  CONCLUSIONS
  In patients with Crohn's disease and low bone mineral density, intravenous pamidronate significantly increases the bone mineral density at the lumbar spine and hip.
authors.affiliation: Musculoskeletal Unit Department of Biochemistry, Freeman Hospital, Newcastle-upon-Tyne, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Bartram
authors.forename: R T
authors.initials: RT
authors.lastname: Peaston
authors.forename: D J
authors.initials: DJ
authors.lastname: Rawlings
authors.forename: R M
authors.initials: RM
authors.lastname: Francis
authors.forename: N P
authors.initials: NP
authors.lastname: Thompson
mesh_terms: D000284:Administration, Oral; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D018488:Bone Demineralization, Pathologic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology / Q000652:urine; D015519:Bone Density; D002118:Calcium / Q000008:administration & dosage*; D003094:Collagen / Q000652:urine; D024042:Collagen Type I; D003424:Crohn Disease / Q000150:complications* / Q000503:physiopathology / Q000652:urine; D004164:Diphosphonates / Q000008:administration & dosage*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D007262:Infusions, Intravenous; D000077268:Pamidronate; D010455:Peptides / Q000652:urine; D016896:Treatment Outcome; D014807:Vitamin D / Q000008:administration & dosage*
chemical_list: D000893:Anti-Inflammatory Agents; D024042:Collagen Type I; D004164:Diphosphonates; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D014807:Vitamin D; D003094:Collagen; D000077268:Pamidronate; D002118:Calcium