title: Historical background for the maternal PKU syndrome.
abstract: OBJECTIVE
  To provide information on the history of maternal phenylketonuria.
  
  
  METHODS
  A review of the literature and personal observations were conducted.
  
  
  RESULTS
  Compilation of sequential information about the development of our understanding of maternal PKU was produced.
  
  
  CONCLUSIONS
  The history of maternal PKU reflects continuous additions to our understanding of this teratogenic syndrome.
authors.affiliation: Division of Genetics, Children's Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA. harvey.levy@tch.harvard.edu
authors.forename: Harvey L
authors.initials: HL
authors.lastname: Levy
mesh_terms: D002648:Child; D005314:Embryonic and Fetal Development; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology / Q000266:history; D006330:Heart Defects, Congenital / Q000209:etiology / Q000266:history; D049673:History, 20th Century; D006801:Humans; D008607:Intellectual Disability / Q000209:etiology / Q000266:history*; D008831:Microcephaly / Q000209:etiology / Q000266:history; D017042:Phenylketonuria, Maternal / Q000150:complications / Q000178:diet therapy / Q000266:history*; D011247:Pregnancy