title: The changes of multifocal electroretinography in the early stage of photodynamic therapy for choroidal neovascularization.
abstract: To investigate short-term changes in the multifocal electroretinography (ERG) recordings after photodynamic therapy (PDT) for choroidal neovascularization (CNV), 16 patients (17 eyes) with classic CNV confirmed by fluorescein angiography (FA) and indocyanine green angiography (ICGA), including 11 cases (12 eyes) of exudative age-related macular degeneration (AMD), two cases (two eyes) of pathological myopia and three cases (three eyes) of idiopathic causes, were treated using PDT with verteporfin. The multifocal ERGs of these patients were tested with VERIS Science 4.0 imaging system. The latencies and average response densities of all six ring retinal regions were measured and compared before PDT and 3 or 7 days after PDT. The latencies and amplitude densities of the N1 and P1 waves in all six rings remained unchanged at 3 or 7 days post-treatment (p > 0.05). Therefore, there is no significant evidence to suggest an adverse effect from PDT for classic CNV on the outer retinal function in the early stage of treatment, with the aid of the multifocal ERG recordings.
authors.affiliation: Department of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing, 100730, China. jlb-jlb@sina.com
authors.forename: Libin
authors.initials: L
authors.lastname: Jiang
authors.forename: Chenjin
authors.initials: C
authors.lastname: Jin
authors.forename: Feng
authors.initials: F
authors.lastname: Wen
authors.forename: Shizhou
authors.initials: S
authors.lastname: Huang
authors.forename: Dezheng
authors.initials: D
authors.lastname: Wu
authors.forename: Lezheng
authors.initials: L
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D020256:Choroidal Neovascularization / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D004596:Electroretinography; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D011930:Reaction Time; D012160:Retina / Q000503:physiopathology*; D014792:Visual Acuity / Q000187:drug effects