[Comparison of serum leptin clearance with different blood purification].
OBJECTIVE
To compare the serum Leptin clearance efficiency with different blood purification treatment.


METHODS
Thirty-one chronic end-stage renal failure hemodialysis (HD) patients (16 men, 15 women, mean age (54.0+/-11.0) years) were enrolled into the study. All the patients were treated with routine hemodialysis, the serum Leptin levels were examined before and after HD. Then they were divided into two groups, one was to be treated with hemodiafiltration (12 patients), and the other was to be treated with blood adsorption (8 patients). The same serum Leptin levels were examined before and after treatment. Serum Leptin concentration was detected by radioimmunoassay (RIA).


RESULTS
The concentration of serum Leptin was not significantly decreased after routine hemodialysis in HD patients ((11.820+/-5.507) microg/L vs. (12.255+/-5.172) microg/L, P>0.05). Leptin concentrations after hemodiafiltration and blood adsorption therapy were decreased to the levels of (29.07+/-8.56) percent and (40.29+/-8.33) percent respectively, and their curative effect was significantly different (P=0.001).


CONCLUSIONS
Routine hemodialysis can influence serum Leptin levels in HD patients. Hemodiafiltration and blood adsorption therapy can lower serum Leptin levels. Blood adsorption therapy is better than hemodiafiltration in the clearance of serum Leptin.
Lou
Tan-qi
TQ
The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China.
You
Yu-ping
YP
Chen
Zhu-jiang
ZJ
Shi
Cheng-gang
CG
Liu
Xun
X
Tang
Hua
H
D000327:Adsorption; D000328:Adult; D000368:Aged; D005260:Female; D017583:Hemodiafiltration; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D020738:Leptin