title: Conicamin, a novel histamine antagonist from the mediterranean tunicate Aplidium conicum.
abstract: In addition to the known 6-bromo-hypaphorine (2) and plakohypaphorine-A (3), the methanol extract of the Mediterranean tunicate Aplidium conicum was shown to contain conicamin, a novel indole alkaloid having histamine-antagonistic activity which structure was determined to be 1 on the basis of the spectral data.
authors.affiliation: Dipartimento di Chimica delle Sostanze Naturali, via D. Montesano, 49, I-80131 Napoli, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Aiello
authors.forename: Francesca
authors.initials: F
authors.lastname: Borrelli
authors.forename: Raffaele
authors.initials: R
authors.lastname: Capasso
authors.forename: Ernesto
authors.initials: E
authors.lastname: Fattorusso
authors.forename: Paolo
authors.initials: P
authors.lastname: Luciano
authors.forename: Marialuisa
authors.initials: M
authors.lastname: Menna
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008968:Molecular Conformation; D015394:Molecular Structure; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D014561:Urochordata / Q000737:chemistry*
chemical_list: D006633:Histamine Antagonists; D026121:Indole Alkaloids; C488270:conicamin