Telomestatin-induced stabilization of the human telomeric DNA quadruplex monitored by electrospray mass spectrometry.
Electrospray mass spectrometry (ESI-MS) was used to monitor the kinetics of duplex formation between the human telomeric DNA quadruplex and its complementary strand; the complexation of telomestatin to the G-quadruplex delays the unwinding of the quadruplex structure and formation of the duplex.
Rosu
Frédéric
F
Department of Chemistry, University of Liege, Sart-Tilman Bat. B6c, B-4000 Liège, Belgium.
Gabelica
Valérie
V
Shin-ya
Kazuo
K
De Pauw
Edwin
E
D004247:DNA / Q000737:chemistry*; D054856:G-Quadruplexes; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000737:chemistry; D010080:Oxazoles / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D016615:Telomere / Q000737:chemistry*; D013696:Temperature
D009841:Oligonucleotides; D010080:Oxazoles; C431888:telomestatin; D004247:DNA