title: Antibiotic prophylaxis with meropenem after allogeneic stem cell transplantation.
abstract: In the present study, we analyze the efficacy of prophylaxis with meropenem in patients receiving a matched related donor allogeneic transplant. In total, 38 patients were sequentially treated with meropenem starting on the day of the first febrile episode (n=17, group A) vs prophylactic meropenem starting on the first day with <500/mm(3) granulocytes (n=21, group B), and maintained until resolution of fever or after granulocyte count >500/mm(3). Of these, 16 (94%) patients in group A developed fever as compared to 16 (76%) in group B (P=0.02). While only one patient in group A did not require first-line antibiotherapy, there were seven (33%) in group B who did not require it (P=0.01) since fever lasted less than 72 h. In addition, 52% patients in group B did not require second-line antibiotics as compared to 11% among patients in group A (P=0.04). In multivariate analysis prophylaxis with meropenem (HR=2.83, 95% CI (1-8.02); P=0.04) and disease status at transplant (HR for early stage=0.15, 95% CI (0.04-0.62); P=0.04) significantly influenced the development of fever. In conclusion, the current pilot study suggests that the use of prophylaxis with meropenem during the period of neutropenia in patients undergoing allogeneic transplantation favorably affects the morbidity of the procedure by reducing febrile episodes.
authors.affiliation: Servicio de Hematología, Hospital Universitario de Salamanca, Paseo de San Vicente, s.n 37007 Salamanca, Spain. pesimo@usal.es
authors.forename: J A
authors.initials: JA
authors.lastname: Pérez-Simón
authors.forename: I
authors.initials: I
authors.lastname: García-Escobar
authors.forename: J
authors.initials: J
authors.lastname: Martinez
authors.forename: L
authors.initials: L
authors.lastname: Vazquez
authors.forename: D
authors.initials: D
authors.lastname: Caballero
authors.forename: C
authors.initials: C
authors.lastname: Cañizo
authors.forename: M V
authors.initials: MV
authors.lastname: Mateos
authors.forename: J F
authors.initials: JF
authors.lastname: San Miguel
mesh_terms: D000208:Acute Disease; D000328:Adult; D001424:Bacterial Infections / Q000453:epidemiology / Q000517:prevention & control*; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D005334:Fever / Q000453:epidemiology / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015994:Incidence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000628:therapy*; D007951:Leukemia, Myeloid / Q000628:therapy*; D008297:Male; D000077731:Meropenem; D008875:Middle Aged; D010865:Pilot Projects; D013845:Thienamycins / Q000008:administration & dosage*
chemical_list: D013845:Thienamycins; D000077731:Meropenem