title: Ureas of 5-aminopyrazole and 2-aminothiazole inhibit growth of gram-positive bacteria.
abstract: Ureas of 5-aminopyrazole and 2-aminothiazole emerged as lead compounds from a high-throughput screen assaying the growth of Staphylococcus aureus. Structure-activity relationships were developed for each compound series. Several compounds were also tested for activity against drug resistant strains of S. aureus in vivo.
authors.affiliation: Genzyme Drug Discovery and Development, Genzyme Corp, Cambridge MA 02139, USA. john.crane@genzyme.com
authors.forename: John L
authors.initials: JL
authors.lastname: Kane
authors.forename: Bradford H
authors.initials: BH
authors.lastname: Hirth
authors.forename: Beirong
authors.initials: B
authors.lastname: Liang
authors.forename: Brian B
authors.initials: BB
authors.lastname: Gourlie
authors.forename: Sharon
authors.initials: S
authors.lastname: Nahill
authors.forename: Gary
authors.initials: G
authors.lastname: Barsomian
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D011720:Pyrazoles; D013844:Thiazoles; D014508:Urea