title: Multiple squamous cell carcinomas of the head and neck show different phenotypes of allelic loss patterns suggesting different clonal origin of carcinogenesis.
abstract: BACKGROUND
  Multiple squamous cell carcinomas in the head and neck are not such a rare phenomenon in patients. To examine if these tumors have the same genetic basis or not, we investigated genetic alterations such as allelic loss in such multiple tumors to see if they showed identical patterns.
  
  
  METHODS
  Patterns of the loss of heterozygosity at 3p, 9p and 17p loci were analyzed in multiple head and neck squamous cell carcinomas of the same patient.
  
  
  RESULTS
  Metachronous laryngeal and tongue tumors of a patient were found to have identical patterns of allelic loss, while synchronous tumors of three other patients had different patterns of such loss.
  
  
  CONCLUSIONS
  Our data support the idea that field carcinogenesis caused by exposure of oral, laryngeal and pharyngeal mucosa to carcinogens may lead to the independent development of synchronous non-related tumors at different sites of the upper aerodigestive tract.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Tohoku University School of Medicine, Sendai, Japan. kshiga@orl.med.tohoku.ac.jp
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Shiga
authors.forename: Takenori
authors.initials: T
authors.lastname: Ogawa
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Yoshida
authors.forename: Kazuto
authors.initials: K
authors.lastname: Matsuura
authors.forename: Masaru
authors.initials: M
authors.lastname: Tateda
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saijo
authors.forename: Taeko
authors.initials: T
authors.lastname: Miyagi
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Kobayashi
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics; D002999:Clone Cells; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000473:pathology; D006801:Humans; D019656:Loss of Heterozygosity; D008297:Male; D008875:Middle Aged; D010641:Phenotype