title: Peptide Epitalon activates chromatin at the old age.
abstract: OBJECTIVES and design. We have studied the effect of synthetic peptide Epitalon on the activity of ribosomal genes, denaturation parameters of total heterochromatin, polymorphism of structural C-heterochromatin and the variability of facultative heterochromatin in cultured lymphocytes of persons aged 76-80 years.
  
  
  RESULTS
  The obtained data demonstrate that Epitalon induces the activation of ribosomal genes, decondensation of pericentromeric structural heterochromatin and the release of genes repressed due to the age-related condensation of euchromatic chromosome regions.
  
  
  CONCLUSIONS
  Epitalon has shown its ability to activate chromatin by modifying heterochromatin and heterochromatinized chromosome regions in the cells of older persons.
authors.affiliation: St Petersburg Institute of Bioregulation and Gerontology of the North-Western Branch of the Russian Academy of Medical Sciences, Russia. khavinson@gerontology.ru
authors.forename: Vladimir Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: Teimuraz A
authors.initials: TA
authors.lastname: Lezhava
authors.forename: Jamlet R
authors.initials: JR
authors.lastname: Monaselidze
authors.forename: Tinatin A
authors.initials: TA
authors.lastname: Jokhadze
authors.forename: Nana A
authors.initials: NA
authors.lastname: Dvalishvili
authors.forename: Nino K
authors.initials: NK
authors.lastname: Bablishvili
authors.forename: Svetlana V
authors.initials: SV
authors.lastname: Trofimova
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D002478:Cells, Cultured; D022041:Euchromatin / Q000187:drug effects / Q000235:genetics; D006570:Heterochromatin / Q000187:drug effects* / Q000235:genetics*; D006358:Hot Temperature; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D009842:Oligopeptides / Q000494:pharmacology*; D011489:Protein Denaturation; D012269:Ribosomal Proteins / Q000235:genetics; D015533:Transcriptional Activation / Q000187:drug effects
chemical_list: D022041:Euchromatin; D006570:Heterochromatin; D009842:Oligopeptides; D012269:Ribosomal Proteins; C421253:alanyl-glutamyl-aspartyl-glycine