Gastrointestinal stromal tumour--a paradigm shift in management of solid tumours.
Gastrointestinal stromal tumour (GIST) till recently were non-responsive to all chemotherapy agents. With the advent of c-kit, diagnosis of GIST has become more specific. STI-571, a tyrosine kinase, has become one of the first targeted therapeutic agent tobe active in solid tumour. At present it is the only agent with substantial activity in GIST.
Bapsy
P P
PP
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bangalore.
Prabhash
K
K
Babu
K G
KG
Girish
M H
MH
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D004621:Embolization, Therapeutic; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D005819:Genetic Markers; D006801:Humans; D000068877:Imatinib Mesylate; D007150:Immunohistochemistry; D009362:Neoplasm Metastasis; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D019009:Proto-Oncogene Proteins c-kit; D011743:Pyrimidines / Q000494:pharmacology / Q000627:therapeutic use*; D018714:Radiotherapy, Adjuvant
D000970:Antineoplastic Agents; D001549:Benzamides; D004791:Enzyme Inhibitors; D005819:Genetic Markers; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D011505:Protein-Tyrosine Kinases; D019009:Proto-Oncogene Proteins c-kit