The effect of repetitive transcranial magnetic stimulation on long-term potentiation in rat hippocampus depends on stimulus intensity.
We investigated the effect of repetitive transcranial magnetic stimulation (rTMS) on long-term potentiation (LTP) in the rat hippocampus. Rats were magnetically stimulated at a rate of 1000 pulses/day for 7 days by a round coil, in which the peak magnetic fields at the center of the coil were 0.75 and 1.00 T. LTP enhancement was observed only in the 0.75-T rTMS group, while no change was observed in the 1.00-T rTMS group. These results suggest that the effect of rTMS on LTP depends on the stimulus intensity.
Ogiue-Ikeda
Mari
M
Department of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-0033, Japan. ogiue@medes.m.u-tokyo.ac.jp
Kawato
Suguru
S
Ueno
Shoogo
S
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods*; D006624:Hippocampus / Q000033:anatomy & histology / Q000502:physiology / Q000528:radiation effects*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000502:physiology / Q000528:radiation effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D050781:Transcranial Magnetic Stimulation