Components of the anti-Müllerian hormone signaling pathway in gonads.
Anti-Müllerian hormone (AMH) is a member of the Transforming Growth Factor-beta (TGF-beta) family implicated in the regression of Müllerian ducts in male fetuses and in the development and function of gonads of both sexes. Members of the TGF-beta family signal through two types of serine/threonine kinase receptors called type I and type II, and two types of Smad proteins, receptor-regulated Smad (R-Smad) and common Smad, Smad4. Components of the AMH signaling pathway have been identified in gonads and gonadal cell lines. The AMH type II receptor is highly specific. In contrast, the identity of the AMH type I receptor is not clear; three type I receptors of Bone Morphogenetic Proteins (BMPs), Alk2, Alk3 and Alk6 may transduce AMH signals, but none of them has all the characteristics of an AMH type I receptor. AMH activates BMP-specific R-Smads and reporter genes.
di Clemente
N
N
Unité INSERM 493, 32 rue des Carnets, Clamart 92140, France. nathalie.diclemente@inserm.ipsc.i-psud.fr
Josso
N
N
Gouédard
L
L
Belville
C
C
D030201:Activin Receptors, Type I / Q000502:physiology; D000818:Animals; D054304:Anti-Mullerian Hormone; D052005:Bone Morphogenetic Protein Receptors, Type I; D004268:DNA-Binding Proteins / Q000502:physiology; D005260:Female; D015870:Gene Expression; D006023:Glycoproteins / Q000502:physiology*; D006066:Gonads / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008297:Male; D009095:Mullerian Ducts / Q000737:chemistry; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D017978:Receptors, Growth Factor / Q000502:physiology; D018000:Receptors, Peptide / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D018125:Receptors, Transforming Growth Factor beta; D015398:Signal Transduction / Q000502:physiology*; D051785:Smad Proteins; D013735:Testicular Hormones / Q000502:physiology*; D015534:Trans-Activators / Q000502:physiology
D004268:DNA-Binding Proteins; D006023:Glycoproteins; D017978:Receptors, Growth Factor; D018000:Receptors, Peptide; D018125:Receptors, Transforming Growth Factor beta; D051785:Smad Proteins; D013735:Testicular Hormones; D015534:Trans-Activators; C084621:anti-Mullerian hormone receptor; D054304:Anti-Mullerian Hormone; D017346:Protein Serine-Threonine Kinases; D030201:Activin Receptors, Type I; C498214:BMPR1B protein, human; D052005:Bone Morphogenetic Protein Receptors, Type I