title: A decade of caspases.
abstract: Caspases are a family of cysteine proteases that play important roles in regulating apoptosis. A decade of research has generated a wealth of information on the signal transduction pathways mediated by caspases, the distinct functions of individual caspases and the mechanisms by which caspases mediate apoptosis and a variety of physiological and pathological processes.
authors.affiliation: Department of Cell Biology, Harvard Medical School, 240 Longwood Ave, Boston, MA 02115, USA.
authors.forename: Alexei
authors.initials: A
authors.lastname: Degterev
authors.forename: Michael
authors.initials: M
authors.lastname: Boyce
authors.forename: Junying
authors.initials: J
authors.lastname: Yuan
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000737:chemistry / Q000145:classification / Q000502:physiology*; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D015533:Transcriptional Activation
chemical_list: D004791:Enzyme Inhibitors; D020169:Caspases