P-selectin and platelet-derived microparticles associated with monocyte activation markers in patients with pulmonary embolism.
Platelet activation markers (platelet-derived microparticles and P-selectin on activated platelets), chemokines (monocyte chemotactic peptide and regulated on activation normally T-cell expressed and secreted), and soluble markers (sP-selectin, sE-selectin, sVCAM-1, and sCD14) were measured and compared in patients with pulmonary embolism (PE). These substances are thought to participate in the pathogenesis of PE. Levels of all of the platelet activation markers, chemokines, and soluble markers were higher in the patients with PE than in normal controls. Levels of platelet activation markers were also significantly increased postoperatively after total knee arthroplasty. Anti-platelet therapy significantly inhibited the elevation of platelet activation markers after total knee arthroplasty. These findings suggest that antiplatelet therapy may be useful for PE-related interaction of platelets, leukocytes, and endothelial cells.
Inami
Norihito
N
Department of Internal Medicine, Kansai Medical Kohri Hospital, Neyagawa, Osaka, Japan.
Nomura
Shosaku
S
Kikuchi
Hiraku
H
Kajiura
Takayuki
T
Yamada
Kohichi
K
Nakamori
Hisahito
H
Takahashi
Nobuyuki
N
Tsuda
Nobuyuki
N
Hikosaka
Makoto
M
Masaki
Motoko
M
Iwasaka
Toshiji
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects; D015415:Biomarkers / Q000032:analysis; D001792:Blood Platelets / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure; D016022:Case-Control Studies; D018925:Chemokines / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D021962:Membrane Microdomains; D008875:Middle Aged; D009000:Monocytes / Q000502:physiology*; D019007:P-Selectin / Q000032:analysis*; D010316:Particle Size; D015539:Platelet Activation; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011655:Pulmonary Embolism / Q000097:blood / Q000209:etiology*
D015415:Biomarkers; D018925:Chemokines; D019007:P-Selectin; D010975:Platelet Aggregation Inhibitors