title: [Study on the relationship between changes of adrenomedulin in plasma and vascular resistance during traumatic shock in rats].
abstract: OBJECTIVE
  To observe the changes of adrenomedulin in plasma and vascular resistance during traumatic shock in rats.
  
  
  METHODS
  The concentration of adrenomedulin in plasma of rats after traumatic shock was detected by radio immunization. Mean arterial pressure, total peripheral vascular resistance (TPVR) and cardiac index (CI) were estimated by electrical conductance method.
  
  
  RESULTS
  The concentration of adrenomedulin in plasma of traumatic shock without resuscitation group (68.34+/-3.71)ng/L and traumatic shock with resuscitation group (146.27+/-9.83)ng/L were higher than that of control group(32.63+/-7.55)ng/L (P<0.01 and P<0.05). TPVR of traumatic shock with resuscitation group (10.57+/-0.35) kPa.s.L-1 was lower than that of traumatic shock without resuscitation group (16.75+/-0.23) kPa.s.L-1(P<0.01) and its CI (215.59+/-1.29) ml.min-1.kg-1 was higher than that of traumatic shock without resuscitation group (143.11+/-0.86) ml.min-1.kg-1 (P<0.01).
  
  
  CONCLUSIONS
  Adrenomedulin is closely correlated with changes of vascular resistance and plays an important role during pathophysiological processes in rats after traumatic shock.
authors.affiliation: Department of General Surgery, First Military Medical University, Guangzhou 510280, Guangdong, China.
authors.forename: Gao-bin
authors.initials: GB
authors.lastname: Sun
authors.forename: Zong-hai
authors.initials: ZH
authors.lastname: Huang
authors.forename: Zhou
authors.initials: Z
authors.lastname: Li
authors.forename: Hui-juan
authors.initials: HJ
authors.lastname: Song
authors.forename: Wei-guo
authors.initials: WG
authors.lastname: Tao
authors.forename: Jun
authors.initials: J
authors.lastname: Long
mesh_terms: D053607:Adrenomedullin; D000818:Animals; D001794:Blood Pressure; D005260:Female; D008297:Male; D010455:Peptides / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012774:Shock, Traumatic / Q000097:blood* / Q000503:physiopathology; D014655:Vascular Resistance
chemical_list: D010455:Peptides; D053607:Adrenomedullin