title: Mycobacterium avium subsp. paratuberculosis infection causes suppression of RANTES, monocyte chemoattractant protein 1, and tumor necrosis factor alpha expression in peripheral blood of experimentally infected cattle.
abstract: Blood from cattle with subclinical Mycobacterium avium subsp. paratuberculosis infection was stimulated with M. avium subsp. paratuberculosis antigens, and expression of interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha), RANTES, monocyte chemoattractant protein 1 (MCP-1), and IL-8 was measured. Expression of TNF-alpha, RANTES, and MCP-1 was lower in infected than in uninfected cattle. The reduced response may weaken protective immunity and perpetuate infection.
authors.affiliation: Paratuberculosis and Inflammatory Bowel Disease Research Team, National Institute of Animal Health, 3-1-5 Kan-nondai, Tsukuba 305-0856, Japan.
authors.forename: Joram J
authors.initials: JJ
authors.lastname: Buza
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Mori
authors.forename: Abusaleh M
authors.initials: AM
authors.lastname: Bari
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Hikono
authors.lastname: Aodon-geril
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Hirayama
authors.forename: Yujing
authors.initials: Y
authors.lastname: Shu
authors.forename: Eiichi
authors.initials: E
authors.lastname: Momotani
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology*; D018932:Chemokine CCL2 / Q000097:blood*; D018946:Chemokine CCL5 / Q000097:blood*; D016927:Mycobacterium avium subsp. paratuberculosis / Q000472:pathogenicity*; D010283:Paratuberculosis / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D018932:Chemokine CCL2; D018946:Chemokine CCL5; D014409:Tumor Necrosis Factor-alpha