title: Specific site involvement in fixed drug eruption.
abstract: A total of 105 patients with established fixed drug eruption (FDE) by oral provocation were evaluated with regard to a drug-related site involvement. Cotrimoxazole was the leading causative agent (63.8%), followed by naproxen sodium (23.8%), dipyrone (5.7%), oxicams (4.8%) and other rare causes (1.9%). Cotrimoxazole most frequently induced lesions on genital mucosa; naproxen and oxicams on lips; and dipyrone on trunk and extremities. Isolated FDE on male genitalia (n = 16) was exclusively because of cotrimoxazole. A highly significant association could be established between naproxen and FDE on lips (chi-square = 28.3; corrected P =.000002). As this study represents the largest series of patients with naproxen-induced FDE, we would suggest that naproxen should be considered as an important potential cause of FDE on lips.
authors.affiliation: Department of Dermatology, Istanbul Medical Faculty, Istanbul University, 34390 Capa, Istanbul, Turkey. bayazit@turk.net
authors.forename: Esen
authors.initials: E
authors.lastname: Ozkaya-Bayazit
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004177:Dipyrone / Q000009:adverse effects; D003875:Drug Eruptions / Q000473:pathology*; D005148:Facial Dermatoses / Q000473:pathology; D005260:Female; D005533:Foot Dermatoses / Q000473:pathology; D005832:Genital Diseases, Male; D006229:Hand Dermatoses / Q000473:pathology; D006801:Humans; D008047:Lip Diseases / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000009:adverse effects; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects
chemical_list: D009288:Naproxen; D004177:Dipyrone; D015662:Trimethoprim, Sulfamethoxazole Drug Combination