[Influence of SEN virus infection on their response to lamivudine in patients with chronic hepatitis B].
OBJECTIVE
To investigate the influence of SEN virus infection on their response to lamivudine in patients with chronic hepatitis B (CHB).


METHODS
SEN virus-D and -H DNA were detected in 45 CHB patients who received lamivudine 12 months with nested-PCR, and YMDD motif mutations in HBV DNA were investigated with gene chip.


RESULTS
The positive rate of SEN virus DNA was 11.1% (5/45), and there were four out of the five SEN virus DNA positive patients whose HBV DNA was positive, among them, two patients existed YMDD motif mutation. While ten out of the forty SEN virus DNA negative patients appeared HBV DNA positive. The response rate was significant lower in SEN virus-infected patients than that in uninfected patients (chi 2=3.97, P<0.05).


CONCLUSIONS
Coinfection with SEN virus in chronic hepatitis B patients may adversely affect the outcome of treatment with lamivudine
Xu
Dong
D
Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Tian
De-Ying
DY
Zhang
Zhen-gang
ZG
Chen
Hong-yun
HY
Song
Pei-hui
PH
D019380:Anti-HIV Agents / Q000494:pharmacology; D004279:DNA, Viral / Q000032:analysis / Q000187:drug effects*; D006515:Hepatitis B virus / Q000187:drug effects* / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000821:virology; D006801:Humans; D019259:Lamivudine / Q000494:pharmacology*; D010253:Respirovirus Infections / Q000150:complications*; D029082:Sendai virus
D019380:Anti-HIV Agents; D004279:DNA, Viral; D019259:Lamivudine