title: Abciximab for the treatment of an acute thrombotic coronary occlusion during stent implantation in a patient with severe hemophilia B.
abstract: Hemophilia B is a severe inherited coagulopathy caused by mutations in the gene that encodes factor IX. Surgical and invasive procedures in patients suffering from this congenital disease are to be considered as being at high risk of hemorrhage. We describe a case of a patient with unstable angina who suffered from severe hemophilia B, pre-treated with plasma purified factor IX concentrate and not on antithrombotic therapy, in whom the use of abciximab induced the complete lysis of an acute thrombus complicating the implantation of a stent on the left anterior descending coronary artery.
authors.affiliation: Department of Cardiology, Azienda Policlinico, Bari, Italy. francesco.bovenzi@tin.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Bovenzi
authors.forename: Leonardo
authors.initials: L
authors.lastname: De Luca
authors.forename: Nicola
authors.initials: N
authors.lastname: Signore
authors.forename: Filomena
authors.initials: F
authors.lastname: Fusco
authors.forename: Italo
authors.initials: I
authors.lastname: de Luca
mesh_terms: D000077284:Abciximab; D000368:Aged; D000789:Angina, Unstable / Q000150:complications / Q000000981:diagnostic imaging / Q000628:therapy*; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000379:methods; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D017023:Coronary Angiography; D003328:Coronary Thrombosis / Q000188:drug therapy* / Q000209:etiology; D005500:Follow-Up Studies; D002836:Hemophilia B / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage*; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D018570:Risk Assessment; D012720:Severity of Illness Index; D015607:Stents; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D010975:Platelet Aggregation Inhibitors; D000077284:Abciximab