Genetics and functional genomics of type 2 diabetes mellitus.
Genome-wide studies of transcription in the skeletal muscle of type 2 diabetic patients have identified coordinated changes in the expression of genes involved in oxidative phosphorylation, and have underlined the central role of the oxidative-phosphorylation regulator, PCG1alpha. These findings help unravel the complex pathogenesis and inheritance of polygenic type 2 diabetes mellitus.
Toye
Ayo
A
The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Gauguier
Dominique
D
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D023281:Genomics / Q000379:methods*; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology; D010085:Oxidative Phosphorylation; D014158:Transcription, Genetic