Constituents of Hypericum laricifolium and their cyclooxygenase (COX) enzyme activities.
Investigation of the aerial parts of the medicinal plant Hypericum laricifolium led to the isolation of two new natural products, hentriacontanyl caffeate (1a), nonacosanyl caffeate (1b). In addition, stigmasterol, beta-sitosterol, 3-epi-betulinic acid (2), caffeic acid (3), ferulic acid, docosanol, p-hydroxybenzoic acid, 3,4-dimethoxy benzoic acid, quercetin (4), quercetin-3-O-galactoside (5), quercetin-3-O-rutinoside (6), quercetin-3-O-rhamnoside (7), quercetin-3-O-glucuronide (8) and shikimic acid were also isolated. The structures were determined by 1D- and 2D-NMR, mass spectrometry, and chemical transformations. The anti-inflammatory effects of the isolated compounds were discussed briefly.
El-Seedi
Hesham Rushdey
HR
Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, Sweden. Hesham.El-Seedi@fkog.uu.se
Ringbom
Therese
T
Torssell
Kurt
K
Bohlin
Lars
L
D000818:Animals; D002417:Cattle; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020902:Hypericum / Q000737:chemistry*; D007527:Isoenzymes / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018514:Plant Structures; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D012756:Sheep
D004791:Enzyme Inhibitors; D007527:Isoenzymes; D010936:Plant Extracts; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases