Whole blood manganese correlates with high signal intensities on T1-weighted MRI in patients with liver cirrhosis.
We examined whole blood (MnB), plasma (MnP) and urinary Mn (MnU) concentrations in 33 cirrhotics and 11 healthy controls to clarify: (1) whether, in chronic liver diseases, MnB or MnP reflects pallidal signal intensities in magnetic resonance imaging (MRI); and (2) which factors in chronic liver diseases correlate with pallidal signal intensities in T1-weighted MRI. Increased signal intensity in the pallidum was observed in 27 (81.8%) of 33 patients with liver cirrhosis in T1-weighted MRI. There was a significant correlation between MnB and pallidal index (PI) (gamma = 0.559, P < 0.01) in the patients. However, no significant correlation was observed between MnP and PI (gamma = 0.353, P > 0.05). According to a multiple linear regression, MnB reflected the signal intensities of T1-weighted MRI better than MnP or MnU. Child/Pugh score and total bilirubin level also correlated with PI. However, the hemoglobin level did not correlate with PI significantly.
Park
Neung Hwa
NH
Department of Internal Medicine, Ulsan University Hospital, #290-3 Cheonha-Dong, Dong-Ku, Ulsan 682-060, South Korea.
Park
Ji Kang
JK
Choi
Younghee
Y
Yoo
Cheol-In
CI
Lee
Choong Ryeol
CR
Lee
Hun
H
Kim
Hyo Kyung
HK
Kim
Sung-Ryul
SR
Jeong
Tae-Heum
TH
Park
Jungsun
J
Yoon
Chung Sik
CS
Kim
Yangho
Y
D000328:Adult; D000368:Aged; D005917:Globus Pallidus / Q000378:metabolism; D006801:Humans; D016014:Linear Models; D008103:Liver Cirrhosis / Q000097:blood*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008345:Manganese / Q000097:blood*; D008875:Middle Aged
D008345:Manganese