title: Increased expression of VEGF in glomeruloid reactive angioendotheliomatosis.
abstract: Reactive angioendotheliomatosis (RAE) is a very rare disorder characterized by marked proliferation of endothelial cells. It is often associated with infections, such as subacute bacterial endocarditis, but has also been described as an early sign of a developing hematological malignancy. We report the case of a 71-year-old Caucasian female who developed lupus-like RAE lesions. A thorough diagnostic workup and subsequent 3-year clinical follow-up revealed no sign of an underlying infectious or neoplastic disorder. Repetitive serum immunofixations were only once consistent with a monoclonal gammopathy of undetermined significance. In lesional skin, the pronounced bud-like endothelial cell formation was associated with an increased epidermal expression of vascular endothelial growth factor (VEGF), a potent angiogenic mediator. In accordance with the paracrine action of epidermally derived VEGF, vascular endothelial cells in lesional skin revealed increased expression of the VEGF receptor VEGFR-2 (KDR). This case suggests a possible role of epidermally derived VEGF in endothelial cell proliferation in RAE.
authors.affiliation: Department of Dermatology, University of Cologne, Cologne, Germany. sabine.eming@uni-koeln.de
authors.forename: Sabine A
authors.initials: SA
authors.lastname: Eming
authors.forename: Christopher
authors.initials: C
authors.lastname: Sacher
authors.forename: Dorothee
authors.initials: D
authors.lastname: Eich
authors.forename: Andreas
authors.initials: A
authors.lastname: Kuhn
authors.forename: Thomas
authors.initials: T
authors.lastname: Krieg
mesh_terms: D000368:Aged; D005260:Female; D006390:Hemangioendothelioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D017445:Skin Diseases, Vascular / Q000378:metabolism* / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis*
chemical_list: D042461:Vascular Endothelial Growth Factor A