[Antisecretory therapy for prevention of stenoses of bougienage after-burn of esophageal strictures].
The purpose of the research was to study the efficacy of the bougienage of after-burn esophageal strictures against the background of long-term treatment with proton pump inhibitors of H2-blockers. 100 patients with after-burn esophageal strictures were divided into 3 groups in a random way: 1) only bougienage--53 patients; 2) bougienage and omeprazole, 20 mg per day during 12 months--20 patients; 3) bougienage and ranitidine, 300 mg per day during 12 months--27 patients. Bougienage was efficient in 83 patients (83%). 17 patients underwent esophagoplasty due to inefficiency of bougienage. Repeated bougienage was necessary for 35% of patients who were taking omeprazole (p = 0.04), 48.1%--ranitidine (p = 0.2), and 60.4% of patients who underwent only bougienage. Bougienage of the esophagus is efficient in treatment of after-burn strictures. Twelve-month treatment of these patients with omeprazole reduces the number of repeated bougienage courses significantly.
Allakhverdian
A S
AS
M.F. Vladimirsky Moscow Regional Clinical Research Institute.
Mazurin
V S
VS
Morozov
S V
SV
Isakov
V A
VA
D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002057:Burns, Chemical / Q000150:complications / Q000628:therapy*; D004940:Esophageal Stenosis / Q000139:chemically induced / Q000517:prevention & control* / Q000628:therapy; D004945:Esophagoscopy; D004947:Esophagus / Q000293:injuries* / Q000601:surgery; D005260:Female; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use; D017494:Proton Pumps / Q000627:therapeutic use; D011899:Ranitidine / Q000627:therapeutic use; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D017494:Proton Pumps; D011899:Ranitidine; D009853:Omeprazole