title: The value of the ultrastructural pattern of myeloperoxidase and platelet peroxidase in identification of two blastic cell types during transformation of a chronic myeloproliferative disorder.
abstract: The value of the ultrastructural pattern of myeloperoxidase (MPO) and plateletperoxidase (PPO) staining is evaluated for the identification of the type of blastic cells during the acute transformation of a chronic myeloproliferative disorder. MPO and PPO are generally accepted as lineage specific markers for the detection of myeloid or megakaryocytic differentiation of the blast cells. The ultrastructural pattern of myeloperoxidase (MPO) and plateletperoxidase (PPO) permitted us to identify two types of blastic cells (one from the myeloid and the other from the megakaryoblastic lineage) in the acute transformation of a chronic myeloproliferative disorders.
authors.affiliation: Victor Babes Institute, Bucharest, Romania.
authors.forename: E
authors.initials: E
authors.lastname: Moldoveanu
authors.forename: A
authors.initials: A
authors.lastname: Moicean
authors.forename: A
authors.initials: A
authors.lastname: Colita
authors.forename: F
authors.initials: F
authors.lastname: Halalau
mesh_terms: D015415:Biomarkers; D001752:Blast Crisis / Q000097:blood* / Q000201:enzymology; D019070:Cell Lineage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood* / Q000201:enzymology / Q000473:pathology; D008533:Megakaryocytes / Q000201:enzymology* / Q000648:ultrastructure; D008875:Middle Aged; D022423:Myeloid Cells / Q000201:enzymology* / Q000648:ultrastructure; D009363:Neoplasm Proteins / Q000097:blood*; D014411:Neoplastic Stem Cells / Q000145:classification / Q000201:enzymology* / Q000648:ultrastructure; D009195:Peroxidase / Q000097:blood*; D010544:Peroxidases / Q000097:blood*
chemical_list: D015415:Biomarkers; D009363:Neoplasm Proteins; D010544:Peroxidases; D009195:Peroxidase