[Kinetics of free-radical oxidation of blood serum as an indicator of tumor effect on organism].
The experiments were made with 83 outbred male rats with transplanted sarcoma-45. The method of initiated chemiluminescence (CL) was used to measure the parameters of blood-serum lipid peroxidation in the animals. The index of free-radical blood-serum lipid peroxidation was shown to reflect in rats the tumor-body ratio. Initially, the kinetic parameters of induced CL were significantly increasing, which was accompanied by a minor remission of the tumor volume. The subsequent stages of tumor growth were associated with increasing, parameters in the studied enzymes' activity, which is apparently related with the expression of genes crucial for the body's antioxidant properties. This enables the tumor cells to escape the monitoring of non-specific cellular immunity with the result being an uncontrollable tumor-volume growth.
Sharipov
F K
FK
Balenkov
Iu O
IuO
Kireev
G V
GV
D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood*; D016166:Free Radical Scavengers / Q000097:blood*; D007700:Kinetics; D008054:Lipid Peroxides / Q000097:blood*; D010084:Oxidation-Reduction; D051381:Rats; D012513:Sarcoma, Experimental / Q000097:blood*
D014408:Biomarkers, Tumor; D016166:Free Radical Scavengers; D008054:Lipid Peroxides