[Chromosomal alterations in juvenile angiofibromas].
BACKGROUND
Despite their benign histological appearance, juvenile angiofibromas, which occur mainly in adolescent males, have a locally aggressive growth pattern. beta-catenin-mutations represent their only known genetic abnormality.


METHODS
Angiofibroma tissue from seven patients was available for comparative genomic hybridization (CGH).


RESULTS
In six out of the seven angiofibromas, CGH detected various abnormalities on 18 different chromosomes. Frequent chromosomal gains were observed on chromosomes 4q, 6q, and 8q. In four out of seven angiofibromas a complete loss of the chromosome Y was detected.


CONCLUSIONS
CGH is a suitable method for the examination of angiofibromas for genetic alterations. Considering the sex distribution of this neoplasm, the frequent loss of chromosome Y is of particular interest.
Brunner
C
C
Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Universitätskliniken des Saarlandes, Kirrberger Strasse, 66421, Homburg/Saar. hnocbru@uniklinik-saarland.de
Urbschat
S
S
Jung
V
V
Praetorius
M
M
Schick
B
B
Plinkert
P K
PK
D000293:Adolescent; D000328:Adult; D018322:Angiofibroma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D041322:Chromosomes, Human, Y; D003598:Cytoskeletal Proteins / Q000235:genetics*; D004252:DNA Mutational Analysis; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D006824:Hybridization, Genetic; D007091:Image Processing, Computer-Assisted; D008297:Male; D008856:Microscopy, Fluorescence; D018715:Microscopy, Video; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D009305:Nasopharynx / Q000473:pathology; D012729:Sex Chromosome Aberrations; D015534:Trans-Activators / Q000235:genetics*; D051176:beta Catenin
C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D004273:DNA, Neoplasm; D015534:Trans-Activators; D051176:beta Catenin