title: Clinical features of infants with subependymal germinolysis and choroid plexus cysts.
abstract: BACKGROUND
  Periventricular cysts are not rare findings in neonates. However, they are sometimes associated with serious clinical complications, such as congenital viral infections and anomalies.
  
  
  METHODS
  We performed a retrospective follow-up study on newborns who had periventricular cysts on routine cranial ultrasound examination.
  
  
  RESULTS
  We followed 13 infants (three preterm) with periventricular cysts. Ten had single or multiple germinolysis cysts and the remaining three had choroid plexus cysts. All infants had various kinds of underlying complications, including congenital viral infection (two with cytomegalovirus and one with rubella),Sotos syndrome (n = 4), intrauterine growth retardation (n = 5), large-for-dates(n = 4), congenital heart disease (n = 1),myelomeningocele (n = 1) and other minor anomalies. All cases of germinolysis except for one developed a neurodevelopmental abnormality and/or delay. In contrast,all three cases with choroid plexus cysts appeared to develop well,despite the underlying complications.
  
  
  CONCLUSIONS
  Germinolysis cysts seem to be associated with systemic diseases and should be treated as a high-risk sign for impaired neurological development.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia.
authors.forename: ElisabethSiti
authors.initials: E
authors.lastname: Herini
authors.forename: Syuichi
authors.initials: S
authors.lastname: Tsuneishi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takada
authors.lastname: Sunarini
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D020863:Central Nervous System Cysts / Q000150:complications / Q000151:congenital* / Q000175:diagnosis; D002657:Child Development; D002831:Choroid Plexus; D004805:Ependyma; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male