title: A dose delivery verification method for conventional and intensity-modulated radiation therapy using measured field fluence distributions.
abstract: Treatment verification has been a weak link in external beam radiation therapy. As new and more complicated treatment techniques, such as intensity-modulated radiation therapy (IMRT), are implemented into clinical practice, verifying the accuracy of treatment delivery becomes increasingly important. Existing methods for treatment verification are highly labor intensive. We have developed a method for verifying the delivery of external beam radiotherapy and implemented the methodology into a system consisting of both hardware and software components. The system uses grayscale images acquired on the treatment machine from the planned treatment beams. From these images, the photon fluence distribution of each beam is derived. These measured photon fluence maps are then used as input to a separate dose calculation engine to compute the delivered absolute dose and the dose distribution in the same patient, assuming that the patient is set up as required by the treatment plan. The dose distribution generated from the measured fluence maps can then be compared to that of the treatment plan. Software tools, such as overlaying isodose curves generated with this method on those imported from the plan, dose difference maps, dose difference volume histograms, and three-dimensional perspective views of the dose differences, have also been developed. The system thus provides a means to verify the dose, the dose prescription, and the monitor units applied. The potential exists with a suitable electronic portal imaging system to reduce the quality assurance efforts, especially for IMRT.
authors.affiliation: Math Resolution, LLC, 5975 Gales Lane, Columbia, Maryland 21045, USA. wendeldrenner@comcast.net
authors.forename: Wendel Dean
authors.initials: WD
authors.lastname: Renner
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Sarfaraz
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Earl
authors.forename: Cedric X
authors.initials: CX
authors.lastname: Yu
mesh_terms: D000465:Algorithms; D005373:Film Dosimetry / Q000295:instrumentation / Q000379:methods / Q000592:standards; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011785:Quality Assurance, Health Care / Q000379:methods* / Q000592:standards; D011874:Radiometry / Q000295:instrumentation* / Q000379:methods* / Q000592:standards; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods* / Q000592:standards; D015203:Reproducibility of Results; D012542:Scattering, Radiation; D012680:Sensitivity and Specificity; D012984:Software