title: [Investigations of poisonings with benzodiazepine derivatives mixtures by thin-layer chromatography].
abstract: The thin-layer chromatography method was proposed for separation and identification of drugs in mixture alprazolam : brotizolam : clorazepate dipotassium. The mixture of these drugs excreted from body fluid (blood) was investigated by the thin-layer chromatography. Most acceptable is this mobile phase : benzene : dioxane : conc. ammonia : methanol : ethanol (60:25:5:10:10). Rf values for drugs: alprazolam 0.81-0.83, brotizolam 0.59-0.62, clorazepate dipotassium 0.67-0.69.
authors.affiliation: Department of Analytical and Toxicological Chemistry, Kaunas University of Medicine, A. Mickeviciaus 9, 3000 Kaunas, Lithuania. augusta@kaunas.init.lt
authors.forename: Augusta
authors.initials: A
authors.lastname: Zevzikoviene
authors.forename: Andrejus
authors.initials: A
authors.lastname: Zevzikovas
authors.forename: Albertas
authors.initials: A
authors.lastname: Bertulis
mesh_terms: D000525:Alprazolam / Q000097:blood / Q000506:poisoning; D014151:Anti-Anxiety Agents / Q000097:blood* / Q000506:poisoning; D001381:Azepines / Q000097:blood / Q000506:poisoning; D001569:Benzodiazepines / Q000097:blood* / Q000506:poisoning; D002855:Chromatography, Thin Layer / Q000379:methods*; D003009:Clorazepate Dipotassium / Q000097:blood / Q000506:poisoning; D006801:Humans; D006993:Hypnotics and Sedatives / Q000097:blood / Q000506:poisoning; D007202:Indicators and Reagents
chemical_list: D014151:Anti-Anxiety Agents; D001381:Azepines; D006993:Hypnotics and Sedatives; D007202:Indicators and Reagents; D001569:Benzodiazepines; C020960:brotizolam; D003009:Clorazepate Dipotassium; D000525:Alprazolam