title: Quantitative structure-activity relationship study on sulfanilamide schiff's bases: carbonic anhydrase (CA) inhibitors.
abstract: The paper deals with quantitative structure-activity studies on a group of sulfanilamide Schiff's base inhibitors of carbonic anhydrase (CA) using distance-based topological indices. The regression analysis of the data has shown that the activities of the compounds used in inhibiting Carbonic AnhydraseII (CAII) activity can be modeled excellently in multi-parametric model in that some indicator parameters are also involved. The results are discussed critically.
authors.affiliation: QSAR and Computer Chemical Laboratories, APS University, Rewa-486 003, India.
authors.forename: Vijay K
authors.initials: VK
authors.lastname: Agrawal
authors.forename: Shachi
authors.initials: S
authors.lastname: Srivastava
authors.forename: Padmakar V
authors.initials: PV
authors.lastname: Khadikar
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
mesh_terms: D024402:Carbonic Anhydrase II / Q000037:antagonists & inhibitors*; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D021281:Quantitative Structure-Activity Relationship; D012545:Schiff Bases / Q000737:chemistry / Q000494:pharmacology*; D013424:Sulfanilamides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D012545:Schiff Bases; D013424:Sulfanilamides; D024402:Carbonic Anhydrase II