title: Long-term suppression of lymphangitic lung metastasis from breast cancer using biweekly docetaxel: a case report.
abstract: A 45-year-old woman underwent a modified radical mastectomy for right breast cancer in July 1996. As lymph node metastases were quite advanced, chemotherapy was started with anthracyclines. Four years after surgery, cough and dyspnea appeared. Chest radiograph and CT showed reticular shadows bilaterally and slight pleural effusion, suggesting lymphangitic lung metastasis of breast cancer. Biweekly intravenous docetaxel (TXT,45 mg/m2) was initiated. Four courses of TXT ameliorated her complaints and radiographic findings. A total of 30 continuous courses of TXT suppressed disease exacerbation for 18 months until new lesions manifested in January 2002. The main side effects were grade 2 leukopenia and alopecia. This case report describes a patient with long-term suppression of lymphangitic lung metastasis of breast cancer using biweekly TXT without severe side effects or worsening quality of life.
authors.affiliation: Second Department of Surgery, Gunma University Faculty of Medicine, 3-39-15, Showa-machi, Maebashi, Gunma 371-8511, Japan. ninomiya@nifty.ne.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Ninomiya
authors.forename: Jun
authors.initials: J
authors.lastname: Horiguchi
authors.forename: Yukio
authors.initials: Y
authors.lastname: Koibuchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Yoshida
authors.forename: Kotaro
authors.initials: K
authors.lastname: Iijima
authors.forename: Miho
authors.initials: M
authors.lastname: Yoshida
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takata
authors.forename: Takao
authors.initials: T
authors.lastname: Yokoe
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Iino
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Morishita
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D000077143:Docetaxel; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000517:prevention & control* / Q000556:secondary*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D043823:Taxoids / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel