Polychlorobiphenyls and other organochlorine compounds in human follicular fluid.
Based on observations in animals, there is an increasing evidence that a number of persistent organochlorine pollutants can alter the endocrine homeostasis, this resulting in toxic effects in particular in the developing organism. However, the role of these chemicals in determining endocrine-related diseases in humans, and possibly a decrease of fertility, is still controversial. Exposure data concerning the human reproductive system are essential for risk assessment. Based on this, the occurrence in follicular fluid of polychlorobiphenyls (PCBs), 2,3,7,8-chlorosubstituted polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), 1,1,1-trichloro-2,2-bis(4-chlorophenyl)-ethane (p,p'-DDT) and its metabolites, and hexachlorobenzene (HCB) was investigated. With respect to PCBs, the sum of the three most abundant congeners (PCBs 138, 153 and 180) was 1230 ng/g, lipid basis (0.37 ng/g, wet weight). Congener distribution profile overlapped what is usually observed in other human tissues, as blood and milk. PCDDs, PCDFs, p,p'-DDT and 1,1-dichloro-2,2-bis(4-chlorophenyl)-ethane (p,p'-DDD) were below their determination limits. 1,1-dichloro-2,2-bis(4-chlorophenyl)-ethene (p,p'-DDE) and HCB were detected in concentrations respectively in the order of 700 and 70 ng/g, lipid basis (approximately 0.2 and approximately 0.02 ng/g, wet weight).
De Felip
Elena
E
Laboratory of Comparative Toxicology and Ecotoxicology, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. defelip@iss.it
di Domenico
Alessandro
A
Miniero
Roberto
R
Silvestroni
Leopoldo
L
D001572:Benzofurans / Q000032:analysis*; D003634:DDT / Q000032:analysis*; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins / Q000032:analysis*; D004784:Environmental Monitoring; D005260:Female; D015571:Follicular Fluid / Q000737:chemistry*; D006581:Hexachlorobenzene / Q000032:analysis*; D006801:Humans; D007558:Italy; D011078:Polychlorinated Biphenyls / Q000032:analysis*
D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins; D006581:Hexachlorobenzene; D003634:DDT; D011078:Polychlorinated Biphenyls