Delayed adverse reactions to iodinated radiographic contrast media after coronary angiography: a search for possible risk factors.
OBJECTIVE
The incidence of and risk factors for delayed adverse events (DAEs) that appear from 1 h to 7 days after injection of radiographic contrast media were investigated in patients who had undergone coronary angiography (CAG).


METHODS
DAEs were monitored by questionnaire in 155 patients who received iomeprol. Isosorbide dinitrate was injected in every case. Risk factors for DAEs were analysed by a logistic regression model.


RESULTS
Of 118 patients who returned questionnaires, 54 complained of DAEs, although no severe or fatal reactions occurred. Erythema, rash and nausea were frequent events. Female gender, total dose of isosorbide dinitrate <2 mg, and execution of acetylcholine provocation test were found to be the major risk factors, and the incidence of DAEs increased as the number of risk factors increased.


CONCLUSIONS
Care should be taken when CAG is performed on female patients who undergo acetylcholine provocation tests and receive low-dose nitric oxide donor injections.
Sakai
N
N
Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Sendo
T
T
Itoh
Y
Y
Hirakawa
Y
Y
Takeshita
A
A
Oishi
R
R
D000368:Aged; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D015994:Incidence; D007479:Iopamidol / Q000009:adverse effects* / Q000031:analogs & derivatives*; D007548:Isosorbide Dinitrate / Q000627:therapeutic use; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013997:Time Factors; D014665:Vasodilator Agents / Q000627:therapeutic use
D003287:Contrast Media; D014665:Vasodilator Agents; C057937:iomeprol; D007548:Isosorbide Dinitrate; D007479:Iopamidol