title: [Agmatine--an endogenous ligand of imidazoline receptors].
abstract: The existence of imidazoline receptors was suggested based on the results of investigation of the central hypotensive action of the alpha 2-adrenoreceptor agonist clonidine containing imidazoline group in the molecule structure. Experiments on the rostral venterolateral medulla oblongata (RVLM) neurons in rats showed that not less that 36% of specific binding sites in this zone differ from adrenergic and recognize imidazoline derivatives. Agmatine has proved to be an endogenous ligand of such imidazoline receptors.
authors.affiliation: Department of Fundamental Medicine, Moscow State University, Lomonosovskii pr. 31/5, Moscow, 117192 Russia.
authors.forename: L P
authors.initials: LP
authors.lastname: Kozaeva
authors.forename: N V
authors.initials: NV
authors.lastname: Korobov
mesh_terms: D000376:Agmatine / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D006801:Humans; D054755:Imidazoline Receptors; D008024:Ligands; D018377:Neurotransmitter Agents / Q000378:metabolism* / Q000494:pharmacology; D011955:Receptors, Drug / Q000378:metabolism*
chemical_list: D054755:Imidazoline Receptors; D008024:Ligands; D018377:Neurotransmitter Agents; D011955:Receptors, Drug; D000376:Agmatine