title: MRI findings in central nervous system systemic lupus erythematosus are associated with immunoserological parameters and hypertension.
abstract: Involvement of the brain is one of the most important complications of systemic lupus erythematosus (SLE). To investigate the correlation between abnormal cranial MRI findings and age, duration of SLE, neuropsychiatric (NP) manifestations, hypertensive status, and the presence of antiphospholipid antibodies (PA) in patients with SLE we evaluated the MRI results of 81 SLE patients in nine NP clinical subgroups.Immunoserological status was described by the presence of lupus anticoagulant (LA), and anticardiolipin antibodies (aCL). The MRI findings were categorized as normal [41], cerebral atrophy [15], small subcortical hyperintensity [7], and infarct larger than 10mm [18]. Mean age differed among the clinical subgroups (ANOVA, p = 0.002), whereas there was no age difference among the subgroups based on MRI and immunoserological results. Patients with hypertension (33/81) were a mean of 6 years older at the time of examination (p = 0.033) and had stroke more frequently, than normotensive ones (p = 0.0015). MRI abnormalities were more frequent in patients with LA positivity (p < 0.01) than in those without these antibodies, and in the hypertensive than in the normotensive subgroup (p = 0.00041). The presence of PA was associated with abnormal MRI even after controlling for the effect of age and hypertensive status (p = 0.011). In our study the MRI findings in central nervous system SLE were independent of the age of patients and the age at the diagnosis of SLE, and were not influenced by the duration of SLE; however, they were associated with immunoserological parameters and hypertension.
authors.affiliation: Dept. of Neurology, University of Debrecen, Nagyerdei krt.98, 4012, Debrecen, Hungary. csepany@jaguar.dote.hu
authors.forename: Tünde
authors.initials: T
authors.lastname: Csépány
authors.forename: Dániel
authors.initials: D
authors.lastname: Bereczki
authors.forename: József
authors.initials: J
authors.lastname: Kollár
authors.forename: Judit
authors.initials: J
authors.lastname: Sikula
authors.forename: Emese
authors.initials: E
authors.lastname: Kiss
authors.forename: László
authors.initials: L
authors.lastname: Csiba
mesh_terms: D000328:Adult; D000367:Age Factors; D017153:Antibodies, Anticardiolipin / Q000097:blood; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications*; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D020945:Lupus Vasculitis, Central Nervous System / Q000097:blood / Q000150:complications / Q000276:immunology / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged
chemical_list: D017153:Antibodies, Anticardiolipin; D016682:Lupus Coagulation Inhibitor