Enteroviruses and type 1 diabetes mellitus.
Despite decades of research, the etiology of type 1 diabetes mellitus (DM) is unknown. Several risk factors have been associated with type 1 DM, including viral infections, genetic predisposition, nutritional factors, and chemicals. Several investigators hypothesize that the etiologies of type 1 DM result from a complex interaction of genetic and environmental factors. In this paper we review the epidemiologic data linking enteroviruses to type 1 DM and discuss potential mechanisms of pathogenesis.
Haverkos
Harry W
HW
Center for Drug Evaluation and Research, Food and Drug Administration, HFD-530, 5600 Fishers Lane, Rockville, MD 20857, USA. haverkosh@cder.fda.gov
Battula
Narayana
N
Drotman
D Peter
DP
Rennert
Owen M
OM
D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics / Q000821:virology*; D004770:Enterovirus / Q000472:pathogenicity / Q000502:physiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D012307:Risk Factors