title: Solitary intracranial extra-osseous plasmacytoma presenting with ophthalmic signs.
abstract: Solitary plasmacytomas rarely develop in the skull, meninges, or brain. Ophthalmic signs as the initial manifestations of solitary intracranial plasmacytoma have rarely been described. We report the neuro-ophthalmologic, imaging, and pathologic findings for two patients. One patient presented with optic neuropathy, the second with bilateral sixth nerve palsies. Plasmacytoma is a treatable intracranial tumor that should be considered in the differential diagnosis of patients who present with optic neuropathy or sixth nerve palsy.
authors.affiliation: Birmingham & Midland Eye Center, City Hospital NHS Trust, Dudley Road, Birmingham B18 7QU, UK. suzanne@brannan43.fsnet.co.uk
authors.forename: Suzanne O
authors.initials: SO
authors.lastname: Brannan
authors.forename: Bethan N
authors.initials: BN
authors.lastname: Matthews
authors.forename: Vijay
authors.initials: V
authors.lastname: Savant
authors.forename: Ray D
authors.initials: RD
authors.lastname: Brown
authors.forename: Timothy D
authors.initials: TD
authors.lastname: Matthews
mesh_terms: D020434:Abducens Nerve Diseases / Q000175:diagnosis* / Q000209:etiology; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000175:diagnosis* / Q000209:etiology; D010954:Plasmacytoma / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy; D014057:Tomography, X-Ray Computed