A new family with the rare genodermatosis keratosis punctata palmoplantaris Buschke-Fischer-Brauer.
We describe a new family with the rare genodermatosis keratosis punctata palmo-plantaris Buschke-Fischer-Brauer (keratoma disseminatum). In all, 3 family members in 3 generations were affected, a pattern consistent with autosomal dominant inheritance. Clinical symptoms started in the third decade with disseminated, small, round, hyperkeratotic papules on the palms and soles. Punctate keratoses coalesced into hyperkeratotic plaques on pressure points. Identification of additional families is necessary to permit definitive genetic classification of this genodermatosis.
Emmert
Steffen
S
Department of Dermatology, University of Göttingen, von-Siebold-Strasse 3, 37075 Göttingen, Germany.
Küster
Wolfgang
W
Zutt
Markus
M
Hänssle
Holger
H
Hallermann
Christian
C
Kretschmer
Lutz
L
Neumann
Christine
C
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007223:Infant; D007645:Keratoderma, Palmoplantar / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010375:Pedigree