Synaptic slaughter in Alzheimer's disease.
Synaptic loss is currently established as the best neurobiological correlate of the cognitive deficits of Alzheimer's disease (AD) [Ann. Neurol. 27 (1990) 457; Ann. Neurol. 30 (1991) 572]. We provide evidence that still living neurons lose synapses in AD, in addition to the synapse loss due to death of neurons. We also provide evidence indicating that in addition to loss of synapses, synaptic function is also affected in AD by decrements in transcript species related to synaptic vesicle trafficking.
Coleman
Paul D
PD
Univesity of Rochester, Center for Aging and Developmental Biology, Rochester, NY 14642, USA. paul_coleman@urmc.rochester.edu
Yao
Pamela J
PJ
D000544:Alzheimer Disease / Q000473:pathology* / Q000503:physiopathology*; D000818:Animals; D020869:Gene Expression Profiling; D006801:Humans; D009410:Nerve Degeneration / Q000473:pathology* / Q000503:physiopathology*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D016874:Neurofibrillary Tangles / Q000378:metabolism / Q000473:pathology; D021381:Protein Transport / Q000502:physiology; D013569:Synapses / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D013572:Synaptic Vesicles / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure
D009419:Nerve Tissue Proteins