title: Ischemic and hemorrhagic disturbances in cerebral circulation alter contractile responses of the rat middle cerebral artery.
abstract: In our study, we examined middle cerebral artery (MCA) contractile responses in two animal models. After hemorrhagic disturbances in rats of Krushinsky-Molodkina strain (KMRs) a decrease in contractile responses to serotonin (5-HT) was observed. During incomplete global cerebral ischemia, MCAs had increased responsiveness to endothelin-1 (ET-1), but reduced responsiveness to serotonin. These findings suggest that cerebral circulation disorders alter cerebrovascular function possibly leading to secondary disturbances in brain circulation.
authors.affiliation: Faculty of Medicine, Lomonosov Moscow State University, Lomonosovsky Pr., 31/5 Moscow 117192, Russia. olevfa@fbm.msu.ru
authors.forename: Olga E
authors.initials: OE
authors.lastname: Fadyukova
authors.forename: Tatiana P
authors.initials: TP
authors.lastname: Storozhevykh
authors.forename: Vsevolod G
authors.initials: VG
authors.lastname: Pinelis
authors.forename: Vladimir B
authors.initials: VB
authors.lastname: Koshelev
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D002543:Cerebral Hemorrhage / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects / Q000502:physiology*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D019332:Endothelin-1 / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D008297:Male; D020768:Middle Cerebral Artery / Q000187:drug effects / Q000503:physiopathology*; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*
chemical_list: D019332:Endothelin-1; D012701:Serotonin