Synthesis and anti-microbial activities of choline-like quaternary ammonium chlorides.
New choline-like quaternary ammonium chlorides were obtained. The work-up procedure of synthesis was quick and efficient. The obtained chlorides showed anti-microbial activities. Quaternary ammonium chlorides derivatives of deanol esters exhibited strong activity and wide anti-bacterial spectra, similar to the activity of benzalkonium chloride. The relationship between chemical structure and anti-microbial activity was analyzed by the QSAR method.
Pernak
Juliusz
J
Poznań University of Technology, pl M Skłodowskiej-Curie 2, 60-965 Poznań, Poland. juliusz.pernak@put.poznan.pl
Chwała
Przemysław
P
D000643:Ammonium Chloride / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002794:Choline / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D021281:Quantitative Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000643:Ammonium Chloride; D002794:Choline