[Effect of mexidol on efficacy of traditional therapy of sick sinus syndrome in adolescents].
ECG data obtained with a Holter monitor in a group of 90 adolescent patients with vegetovascular dystonia and sick sinus syndrome (SSS) showed that mexidol, intravenously instilled in a daily dose of 2-4 mg/kg over a period of 10 days in combination with a standard neurometabolic scheme results in the development of a therapeutic effect in 93-100% of patients with clinical-ECG variants I and II of the disorder. In most cases, both clinical state and ECG quality were improved and the functional capacity of myocardium was increased. Repeated courses of mexidol administration increased efficacy of the ambulatory SSS treatment on the average by 20%.
Balykova
L A
LA
Department of Pediatry, Mordvinian State University, ul. Ul'yanova 26, Saransk, Mordvinia, 430003 Russia.
D000293:Adolescent; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002648:Child; D004359:Drug Therapy, Combination; D015716:Electrocardiography, Ambulatory; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010847:Picolines / Q000008:administration & dosage / Q000627:therapeutic use*; D012804:Sick Sinus Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome
D000975:Antioxidants; D002317:Cardiovascular Agents; D010847:Picolines; C070020:emoxypine succinate