title: [Comparison of serum leptin clearance with different blood purification].
abstract: OBJECTIVE
  To compare the serum Leptin clearance efficiency with different blood purification treatment.
  
  
  METHODS
  Thirty-one chronic end-stage renal failure hemodialysis (HD) patients (16 men, 15 women, mean age (54.0+/-11.0) years) were enrolled into the study. All the patients were treated with routine hemodialysis, the serum Leptin levels were examined before and after HD. Then they were divided into two groups, one was to be treated with hemodiafiltration (12 patients), and the other was to be treated with blood adsorption (8 patients). The same serum Leptin levels were examined before and after treatment. Serum Leptin concentration was detected by radioimmunoassay (RIA).
  
  
  RESULTS
  The concentration of serum Leptin was not significantly decreased after routine hemodialysis in HD patients ((11.820+/-5.507) microg/L vs. (12.255+/-5.172) microg/L, P>0.05). Leptin concentrations after hemodiafiltration and blood adsorption therapy were decreased to the levels of (29.07+/-8.56) percent and (40.29+/-8.33) percent respectively, and their curative effect was significantly different (P=0.001).
  
  
  CONCLUSIONS
  Routine hemodialysis can influence serum Leptin levels in HD patients. Hemodiafiltration and blood adsorption therapy can lower serum Leptin levels. Blood adsorption therapy is better than hemodiafiltration in the clearance of serum Leptin.
authors.affiliation: The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong, China.
authors.forename: Tan-qi
authors.initials: TQ
authors.lastname: Lou
authors.forename: Yu-ping
authors.initials: YP
authors.lastname: You
authors.forename: Zhu-jiang
authors.initials: ZJ
authors.lastname: Chen
authors.forename: Cheng-gang
authors.initials: CG
authors.lastname: Shi
authors.forename: Xun
authors.initials: X
authors.lastname: Liu
authors.forename: Hua
authors.initials: H
authors.lastname: Tang
mesh_terms: D000327:Adsorption; D000328:Adult; D000368:Aged; D005260:Female; D017583:Hemodiafiltration; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
chemical_list: D020738:Leptin