title: Allogeneic hematopoietic stem cell transplantation in a patient affected by large granular lymphocyte leukemia and multiple sclerosis.
abstract: We describe a 57-year-old man, affected by large granular lymphocyte (LGL) leukemia and concomitant primary progressive multiple sclerosis (MS), treated with allogeneic hematopoietic stem cell transplantation (HSCT) from an HLA-identical sibling. The patient was conditioned with fludarabine, busulphan, and cyclophosphamide. Graft-versus-host disease (GVHD) prophylaxis consisted of cyclosporine and short-term methotrexate. At 3 years follow-up, the patient is in complete remission of LGL with a marked improvement in neurological conditions. This is the first case of allogeneic HSCT in a patient with LGL leukemia and concomitant primary progressive MS. Allogeneic HSCT, performed in our patient to cure the lymphoproliferative disorder, improved the clinical course of MS.
authors.affiliation: Centro Trapianti di Midollo Osseo, Centro Regionale Trapianti, Ospedale R. Binaghi ASL n degrees 8, Via Is Guadazzonis, 3, 09126 Cagliari, Italy. lanasa@tiscalinet.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: La Nasa
authors.forename: Roberto
authors.initials: R
authors.lastname: Littera
authors.forename: Eleonora
authors.initials: E
authors.lastname: Cocco
authors.forename: Luca
authors.initials: L
authors.lastname: Battistini
authors.forename: Maria Giovanna
authors.initials: MG
authors.lastname: Marrosu
authors.forename: Licinio
authors.initials: L
authors.lastname: Contu
mesh_terms: D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D015458:Leukemia, T-Cell / Q000150:complications / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications / Q000473:pathology / Q000628:therapy*; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous; D016896:Treatment Outcome