title: Cystectomy and orthotopic ileal neobladder in a male patient 12 years after kidney transplantation; good preservation of the renal function.
abstract: In case of cystectomy, some forms of urinary diversion can impair the graft function of renal transplant patients. Here we present the case of a 70-year-old male with carcinoma of the bladder 12 years after renal transplantation. Immunosuppression was achieved with Cyclosporin A (200 mg/day) and Prednisone (5 mg/day). The patient's serum creatinine level was 1.4 mg/dl. Following cystectomy, an orthotopic ileal neobladder was constructed by means of Studer technique, and the afferent ileal loop was anastomosed to the graft ureter. Pathology revealed pT1 G3 N+ transitional cell carcinoma. Ten months later, periaortic nodal recurrences necessitated four cycles of chemotherapy with Epidoxorubicyn and Gemcytabine. To date, 20 months after cystectomy, the patient is stable, with day and night-time urinary continence. His serum creatinine level is 1.3 mg/dl, and there is no evidence of hydronephrosis or acidosis. We conclude that the orthotopic ileal neobladder is an effective form of urinary diversion in renal transplant patients requiring cystectomy, allowing good preservation of the renal function.
authors.affiliation: Urologia Universitaria, Dipartmento di Chirurgia, Via Roma 67, 56126 Pisa, Italy. c.selli@dc.med.unipi.it
authors.forename: Cesare
authors.initials: C
authors.lastname: Selli
authors.forename: Ugo
authors.initials: U
authors.lastname: Boggi
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Travaglini
authors.forename: Fabio
authors.initials: F
authors.lastname: Vistoli
authors.forename: Marco
authors.initials: M
authors.lastname: Del Chiaro
authors.forename: Franco
authors.initials: F
authors.lastname: Mosca
mesh_terms: D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000601:surgery; D003404:Creatinine / Q000097:blood; D015653:Cystectomy; D006801:Humans; D007082:Ileum / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D011183:Postoperative Complications / Q000601:surgery; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000601:surgery*; D001749:Urinary Bladder Neoplasms / Q000601:surgery*
chemical_list: D003404:Creatinine