title: 1,3-dihydrobenzo[c]furan nucleoside analogues: additional studies of the thymine derivative.
abstract: The detailed study of the 1,3-dihydrobenzo[c]furan derivative of thymine is reported. The lack of anti-HIV activity of this compound in cell culture experiments is shown to be related to the inability of the corresponding 5'-triphosphate derivative to interact efficiently with the reverse transcriptase.
authors.affiliation: UMR 5625 CNRS-UM II, Université Montpellier II, cc 008, place E. Bataillon, 34095 Cedex 5, Montpellier, France.
authors.forename: David
authors.initials: D
authors.lastname: Egron
authors.forename: Christian
authors.initials: C
authors.lastname: Périgaud
authors.forename: Gilles
authors.initials: G
authors.lastname: Gosselin
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Aubertin
authors.forename: Abdesslem
authors.initials: A
authors.lastname: Faraj
authors.forename: Majid
authors.initials: M
authors.lastname: Sélouane
authors.forename: Denis
authors.initials: D
authors.lastname: Postel
authors.forename: Christophe
authors.initials: C
authors.lastname: Len
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry; D001572:Benzofurans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006207:Half-Life; D006863:Hydrogen-Ion Concentration; D009705:Nucleosides; D018119:Stavudine / Q000737:chemistry; D013329:Structure-Activity Relationship; D013941:Thymine / Q000031:analogs & derivatives*
chemical_list: D019380:Anti-HIV Agents; D001572:Benzofurans; D009705:Nucleosides; D018119:Stavudine; D013941:Thymine