[Nicorandil reduces incidence and severity of pain on propofol injection].
BACKGROUND
Propofol is commonly used for induction and maintenance of anesthesia, but the pain during injection of propofol remains a clinical problem. We studied whether nicorandil prevents the pain on propofol injection.


METHODS
The study was conducted in 120 adult patients scheduled for elective surgery. The patients were assigned to two groups; Group C (n = 60) received bolus injection of propofol alone; Group N (n = 60) received bolus injection of 2 mg of nicrorandil 3 minutes before propofol injection, and followed by continuous nicorandil infusion at a rate of 6 mg.h-1. The pain on injection was assessed as, none, mild, moderate, or severe at 15-second intervals.


RESULTS
The incidence of propofol-induced pain was significantly higher in Group C (77%) than in Group N (30%) (P < 0.05). The severity of pain was significantly higher in Group C than in Group N (P < 0.05).


CONCLUSIONS
Nicorandil reduces the incidence and severity of pain on propofol injection.
Yoshimura
Yasuhiro
Y
Department of Anesthesiology, Hakodate National Hospital, Hakodate 041-8512.
Iwasaki
Tatsuma
T
Shimizu
Yukio
Y
Takasaki
Mayumi
M
D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D020108:Nicorandil / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000517:prevention & control*; D015742:Propofol / Q000008:administration & dosage* / Q000009:adverse effects*; D012720:Severity of Illness Index
D018686:Anesthetics, Intravenous; D020108:Nicorandil; D015742:Propofol