title: Eukaryotic domain evolution inferred from genome comparisons.
abstract: Comparative analyses of eukaryotic genomes are providing insights into the mode and tempo of domain family evolution. Gene duplication, the source of family expansion, far exceeds the rate of emergence of domains from non-coding sequence, and the rate of recruitment of domains into novel architectures. Domain families that appear to be restricted to certain lineages are likely to be the result of gene duplication, coupled with rapid sequence diversification. If such families are evidence of past adaptation, then their functions must relate to the underlying mechanism of selection: competition among organisms.
authors.affiliation: Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
authors.forename: Richard R
authors.initials: RR
authors.lastname: Copley
authors.forename: Leo
authors.initials: L
authors.lastname: Goodstadt
authors.forename: Chris
authors.initials: C
authors.lastname: Ponting
mesh_terms: D000818:Animals; D005057:Eukaryotic Cells; D019143:Evolution, Molecular; D020440:Gene Duplication; D016678:Genome; D006801:Humans; D017434:Protein Structure, Tertiary; D012641:Selection, Genetic