title: A pH-mucosa area unit of measure to consider morphology of the oesophagus when evaluating oesophagitis.
abstract: Gastro-oesophageal pH measurements are routinely carried out to quantify and determine if levels of acid reflux are responsible for symptoms. Although considered the 'gold standard', evidence suggests that pH measurements do not correlate well with the degree of oesophagitis seen during endoscopy. In this study the current measure of pH was critically examined taking into account both the effects of changes in luminal diameter and endoscopy observations. The oesophageal lumen diameter was investigated using a barium swallow for 25 patients presenting with oesophageal disorders. For each subject the widest luminal diameter was measured for a series of five controlled swallows. The results showed that the lumen diameter varied widely from 0.9 to 3.8 cm. An alternative approach to the current measurement of pH was explored. In this approach the exposure not only included the luminal pH and time exposed but also the area of mucosa exposed as a result of differing luminal diameters. Although it is currently not possible to assess the diameter or morphology of the oesophageal lumen during a pH study, the analysis highlighted that the current measure of pH exposure time does not include the area of mucosa exposed. These results may explain, to some extent, the poor correlation between pH measurements and degree of oesophagitis seen during endoscopy.
authors.affiliation: GI Investigation Unit, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK. k.haylett@computer.org
authors.forename: K R
authors.initials: KR
authors.lastname: Haylett
authors.forename: P
authors.initials: P
authors.lastname: Vales
authors.forename: S H
authors.initials: SH
authors.lastname: Lee
authors.forename: R F
authors.initials: RF
authors.lastname: McCloy
mesh_terms: D001466:Barium Sulfate; D003287:Contrast Media; D003679:Deglutition / Q000502:physiology; D004941:Esophagitis / Q000378:metabolism / Q000473:pathology*; D004947:Esophagus / Q000737:chemistry / Q000473:pathology*; D005764:Gastroesophageal Reflux / Q000473:pathology; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008365:Manometry; D009092:Mucous Membrane / Q000737:chemistry / Q000473:pathology
chemical_list: D003287:Contrast Media; D001466:Barium Sulfate