MR demonstration of partial lesions of the lateral geniculate body and its functional intra-nuclear topography.
Two rare cases with a partial lesion of the lateral geniculate body (LGB) presumably due to ischemia are demonstrated on high resolution MR imaging. A 62-year-old woman (case 1) presented with left homonymous superior quadrantanopia on Goldmann perimetry. Heavily T2 weighted MR images showed a localized lesion at the lateral portion of the LGB. The visual field defect was macular and horizontal meridian sparing and persisted for 9 years. A 49-year-old woman (case 2) presented with a sudden onset of left homonymous horizontal sectoranopia on Humphrey automated perimetry and heavily T2 weighted images demonstrated a lesion localized at the more medial part of the right LGB. Axons originating from inferior, central and superior retina are essentially located laterally, centrally and medially, respectively, in the LGB, based on the electrophysiological studies of animal experiments and this observation has been applied to humans. This study radiologically shows that a discrete lateral lesion of the LGB produced homonymous upper quadrantanopia in case 1, whereas a more medially located lesion produced homonymous sectoranopia in case 2, and reveals that the axons originating from inferior retina are located more laterally than those from central retina in the human LGB.
Saeki
Naokatsu
N
Departments of Neurological Surgery and Ophthalmology, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuoh-ku, Chiba-shi, Chiba 260-8670, Japan. saeki@med.m.chiba-u.ac.jp
Fujimoto
Naoya
N
Kubota
Motoo
M
Yamaura
Akira
A
D001369:Axons / Q000473:pathology; D002545:Brain Ischemia / Q000175:diagnosis*; D001931:Brain Mapping; D002544:Cerebral Infarction / Q000175:diagnosis*; D002829:Choroid / Q000098:blood supply / Q000473:pathology; D003937:Diagnosis, Differential; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005829:Geniculate Bodies / Q000098:blood supply* / Q000473:pathology; D006423:Hemianopsia / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D020656:Posterior Thalamic Nuclei / Q000098:blood supply / Q000473:pathology; D012160:Retina / Q000473:pathology; D058609:Visual Field Tests; D014795:Visual Pathways / Q000473:pathology