title: Human ileal bile acid-binding protein promoter and the effects of CDX2.
abstract: The ileal bile acid-binding protein (IBABP) is important for the reabsorption of bile salts in the distal small intestine. Studies with the human IBABP gene (FABP6, on chromosome 5q33.3-q34) defined the major transcription start site and identified conserved elements. A consensus element for the caudal-related homeobox factor CDX2 was functional in gel-shift assays and in transfection experiments.
authors.affiliation: Gastroenterology Section, Faculty of Medicine, Imperial College London, UK.
authors.forename: Natalie F
authors.initials: NF
authors.lastname: Barley
authors.forename: Vivienne
authors.initials: V
authors.lastname: Taylor
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Shaw-Smith
authors.forename: Probir
authors.initials: P
authors.lastname: Chakravarty
authors.forename: Alison
authors.initials: A
authors.lastname: Howard
authors.forename: Stephen
authors.initials: S
authors.lastname: Legon
authors.forename: Julian R F
authors.initials: JR
authors.lastname: Walters
mesh_terms: D001483:Base Sequence; D000071616:CDX2 Transcription Factor; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D006913:Hydroxysteroid Dehydrogenases; D007082:Ileum / Q000378:metabolism*; D008562:Membrane Glycoproteins; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D015534:Trans-Activators; D045002:3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
chemical_list: D000071616:CDX2 Transcription Factor; D002352:Carrier Proteins; D018398:Homeodomain Proteins; D006913:Hydroxysteroid Dehydrogenases; D008562:Membrane Glycoproteins; D015534:Trans-Activators; C037643:bile acid binding proteins; C435496:AKR1C2 protein, human; D045002:3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)