title: Raman dye-labeled nanoparticle probes for proteins.
abstract: In this paper, we demonstrate how one can chemically design Raman dye-functionalized nanoparticle probes with specific protein-binding affinities and use these probes, coupled with surface-enhanced Raman scattering (SERS) spectroscopy, to perform multiplexed screening of protein-small molecule interactions and protein-protein interactions in a protein microarray format.
authors.affiliation: Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.
authors.forename: Y Charles
authors.initials: YC
authors.lastname: Cao
authors.forename: Rongchao
authors.initials: R
authors.lastname: Jin
authors.forename: Jwa-Min
authors.initials: JM
authors.lastname: Nam
authors.forename: C Shad
authors.initials: CS
authors.lastname: Thaxton
authors.forename: Chad A
authors.initials: CA
authors.lastname: Mirkin
mesh_terms: D019297:2,4-Dinitrophenol / Q000737:chemistry; D000911:Antibodies, Monoclonal / Q000737:chemistry; D001710:Biotin / Q000737:chemistry; D004076:Digoxigenin / Q000737:chemistry; D006873:Hydroquinones / Q000737:chemistry; D036103:Nanotechnology; D010316:Particle Size; D040081:Protein Array Analysis / Q000379:methods*; D011506:Proteins / Q000032:analysis*; D012834:Silver / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods*
chemical_list: D000911:Antibodies, Monoclonal; D006873:Hydroquinones; D011506:Proteins; D012834:Silver; D001710:Biotin; D004076:Digoxigenin; D019297:2,4-Dinitrophenol; C031927:hydroquinone