Ligands of the peroxisome proliferator-activated receptor-gamma and heart failure.
Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. The PPAR subfamily comprises of three members, PPAR-alpha, PPAR-beta and PPAR-gamma. There is good evidence that ligands of PPAR-gamma, including certain thiazolinediones, reduce myocardial tissue injury and infarct size. The use of PPAR-gamma agonists in the treatment of heart failure is, however, controversial.
Thiemermann
C
C
The Department of Experimental Medicine, Nephrology and Critical Care, William Harvey Research Institute, St Bartholomew's and The Royal London School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ. c.thiemermann@qmul.ac.uk
D000818:Animals; D004195:Disease Models, Animal; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008024:Ligands; D051379:Mice; D009203:Myocardial Infarction / Q000188:drug therapy / Q000473:pathology; D047495:PPAR gamma / Q000627:therapeutic use*; D000077205:Pioglitazone; D051381:Rats; D013844:Thiazoles / Q000494:pharmacology / Q000627:therapeutic use; D045162:Thiazolidinediones / Q000494:pharmacology / Q000627:therapeutic use
D008024:Ligands; D047495:PPAR gamma; D013844:Thiazoles; D045162:Thiazolidinediones; D000077205:Pioglitazone