Anti-Müllerian hormone and its role in ovarian function.
Anti-Müllerian hormone (AMH) is expressed after birth in the ovary in the granulosa cells of healthy, small growing follicles. We have shown that AMH affects two important regulatory steps during folliculogenesis. At initial recruitment, AMH inhibits recruitment of primordial follicles into the growing pool, while at cyclic recruitment AMH lowers the FSH-sensitivity of follicles. In these ways, AMH plays an important role in regulation of ovarian follicle growth. AMH serum level is a strong candidate marker for ovarian reserve in women. In normo-ovulatory women, AMH serum levels correlated strongly with the number of antral follicles. In addition, AMH is a strong predictor for the number of oocytes retrieved in patients undergoing IVF treatment. The convenience of determination and its relative stable expression during the menstrual cycle indicate that further validation of the use of serum AMH is recommended as a clinical measure of ovarian reserve.
Gruijters
Maria J G
MJ
Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands.
Visser
Jenny A
JA
Durlinger
Alexandra L L
AL
Themmen
Axel P N
AP
D000328:Adult; D000375:Aging / Q000097:blood; D000818:Animals; D054304:Anti-Mullerian Hormone; D005260:Female; D005298:Fertility / Q000502:physiology; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000502:physiology; D006023:Glycoproteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D006080:Ovarian Follicle / Q000254:growth & development / Q000502:physiology; D010053:Ovary / Q000502:physiology*; D013735:Testicular Hormones / Q000235:genetics / Q000502:physiology*
D006023:Glycoproteins; D013735:Testicular Hormones; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone