title: Genomic approaches in Xanthomonas campestris pv. vesicatoria allow fishing for virulence genes.
abstract: Xanthomonas campestris pv. vesicatoria is an economically important pathogen of pepper and tomato and has been established as a model organism to study bacterial infection strategies. In the last two decades, intensive genetic and molecular analyses led to the isolation of many genes that play a role in the intimate molecular relationship with the host plant. Essential for pathogenicity is a type III protein secretion system, which delivers bacterial effector proteins into the host cell. Currently, the genome of X. campestris pv. vesicatoria is being sequenced. The availability of genomic sequence information will pave the way for the identification of new bacterial virulence factors by bioinformatic approaches. In this article, we will present preliminary data from the genomic sequence analysis and describe recent and novel studies to identify bacterial type III effector genes.
authors.affiliation: Institut für Genetik, Martin-Luther-Universität Halle-Wittenberg, D-06099 Halle(Saale), Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Büttner
authors.forename: Laurent
authors.initials: L
authors.lastname: Noël
authors.forename: Frank
authors.initials: F
authors.lastname: Thieme
authors.forename: Ulla
authors.initials: U
authors.lastname: Bonas
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics; D016680:Genome, Bacterial; D023281:Genomics / Q000379:methods; D010935:Plant Diseases / Q000382:microbiology*; D037521:Virulence Factors / Q000235:genetics*; D016959:Xanthomonas campestris / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity*
chemical_list: D037521:Virulence Factors