title: Mobile elements and mammalian genome evolution.
abstract: Mobile elements make up large portions of most eukaryotic genomes. They create genetic instability, not only through insertional mutation but also by contributing recombination substrates, both during and long after their insertion. The combination of whole-genome sequences and the development of innovative new assays to test the function of mobile elements have increased our understanding of how these elements mobilize and how their insertion impacts genome diversity and human disease.
authors.affiliation: Department of Environmental Health Sciences, Tulane University Health Sciences Center, New Orleans, LA 70112, USA. pdeinin@tulane.edu
authors.forename: Prescott L
authors.initials: PL
authors.lastname: Deininger
authors.forename: John V
authors.initials: JV
authors.lastname: Moran
authors.forename: Mark A
authors.initials: MA
authors.lastname: Batzer
authors.forename: Haig H
authors.initials: HH
authors.lastname: Kazazian
mesh_terms: D000818:Animals; D005057:Eukaryotic Cells; D019143:Evolution, Molecular; D014644:Genetic Variation; D016678:Genome; D042822:Genomic Instability; D006801:Humans; D020071:Interspersed Repetitive Sequences; D008322:Mammals / Q000235:genetics*; D018626:Retroelements / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D018626:Retroelements