title: Cutaneous T-cell lymphomas: a review with emphasis on new treatment approaches.
abstract: Primary cutaneous T-cell lymphomas represent a wide variety of non-Hodgkin lymphomas that are characterized by a distinct clinical presentation. Advanced molecular and biological techniques have enhanced the recognition of cutaneous T-cell lymphomas. The most common subtypes of cutaneous T-cell lymphomas are the epidermotropic variants mycosis fungoides and Sézary syndrome. At present, a stage-adjusted therapy is the best concept available, since early aggressive treatment options did not improve the prognosis of patients with cutaneous T-cell lymphomas. Accurate diagnostic and clinical assessment as well as identification of prognostic factors provides a helpful basis for treatment strategies. Current medical literature on diagnosis, prognosis, and treatment is reviewed with emphasis on new biologic response-modifying treatment options.
authors.affiliation: Division of Hematology/Oncology, Department of Dermatology, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. c-querfeld@northwestern.edu
authors.forename: Christiane
authors.initials: C
authors.lastname: Querfeld
authors.forename: Steven T
authors.initials: ST
authors.lastname: Rosen
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Kuzel
authors.forename: Joan
authors.initials: J
authors.lastname: Guitart
mesh_terms: D001691:Biological Therapy / Q000379:methods*; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology* / Q000628:therapy*; D009367:Neoplasm Staging; D012878:Skin Neoplasms / Q000473:pathology / Q000628:therapy*