[Age-related post-translational modification of proteins in human tissue and its use determination of age in forensic medicine. Review].
This article deals with some of posttranslational modification of proteins which are, or could be useful to work out objective and standard methods for age estimation in forensic medicine. From many posttranslational modifications other than racemization, the evaluation of pentosidine, one of the products of nonenzymatic glycosylation, seems to be promising. The enlargement of menu of methods for age estimation is important mainly for forensic sciences when determination of the age of an unknown dead body is necessary. Morphological methods are quite often subjective and charged with errors.
Pilin
A
A
Ustav soudního lékarství a toxikologie 1. LF UK a VFN, Praha.
Pudil
F
F
Sajdok
J
J
Zídková
J
J
Bezdícková
D
D
Bencko
V
V
D000375:Aging / Q000378:metabolism*; D001120:Arginine / Q000031:analogs & derivatives* / Q000378:metabolism; D005554:Forensic Medicine / Q000379:methods*; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000378:metabolism; D011499:Protein Processing, Post-Translational
D017127:Glycation End Products, Advanced; D001120:Arginine; C062187:pentosidine; D008239:Lysine