Determining a detectable threshold of signal intensity in cDNA microarray based on accumulated distribution.
In microarray data mining, one of the key problems is how to handle weak signals. Based on a bent piecewise linear accumulated distribution generally found in the microarray data, a new detectable threshold finding method is proposed to filter genes with unreliable information in this paper. More reliable and reproducible data is produced for the subsequent data mining.
Gao
Xia
X
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai 200433, PR China.
Fu
Xuping
X
Li
Tao
T
Zi
Jian
J
Luo
Yao
Y
Wei
Qing
Q
Zeng
Erliang
E
Xie
Yi
Y
Li
Yao
Y
Mao
Yumin
Y
D018076:DNA, Complementary / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D015203:Reproducibility of Results
D018076:DNA, Complementary