Triplet pregnancy after oocyte donation in women 46 years of age and older: three case reports.
OBJECTIVE
Presentation of three triplet pregnancies achieved in women 46 years of age and older with the use of donated oocytes.


METHODS
Two healthy perimenopausal women 46 and 48 years old and one healthy menopausal woman 48 years old, requesting fertility options. All of them followed oocyte donation programs resulting in triplet pregnancy. Maternal as well as perinatal complications, mode of delivery and birth weight are reported.


RESULTS
Three triplet pregnancies were achieved using donated oocytes. Prenatal diagnosis was reassuring. Preterm rupture of membranes, preterm labor and gestational diabetes complicated the pregnancies. Cesarean section was the mode of delivery for all the cases giving birth to nine healthy neonates weighing between 1,130 and 2,450 g. No postpartum complications were encountered.


CONCLUSIONS
Triplet pregnancies achieved with the use of donated oocytes at a very advanced maternal age represent high-risk obstetrical cases. Cautious prenatal evaluation of maternal health and intensive antenatal surveillance are imperative principles allowing the most favorable outcome of these pregnancies.
Makrakis
E
E
Centre for Human Reproduction, Athens, Greece.
Grammatis
M
M
Vitoratos
N
N
Stavrou
D
D
Karantzis
P
P
Pantos
K
K
D002585:Cesarean Section; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005500:Follow-Up Studies; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged; D018587:Oocyte Donation; D011247:Pregnancy; D011256:Pregnancy Outcome; D011272:Pregnancy, Multiple; D018570:Risk Assessment; D014310:Triplets