Microwave-assisted [3 + 2] cycloadditions of azomethine ylides.
The microwave-assisted intramolecular [3 + 2] cycloaddition reaction of azomethine ylides to activated and nonactivated alkenes and alkynes is described. The procedure allows the synthesis of pyrrolidines and pyrrole products in good to excellent overall yields in short reaction times. It appears from parallel comparative studies that the microwave procedure favors the reaction times and overall purity of the crude reaction mixture. The reactions can also be performed in the absence of solvent. [reaction: see text]
Bashiardes
George
G
Département de Chimie, Méthodologie et Synthèse de Biomolécules, SFA-UMR 6514, Université de Poitiers, 40 avenue du Recteur Pineau, 86022 Poitiers, France. george.bashiardes@univ-poitiers.fr
Safir
Imad
I
Mohamed
Achmet Said
AS
Barbot
Francis
F
Laduranty
Joelle
J