title: Incidence and prevalence of multiple sclerosis in Olmsted County, Minnesota, 1985-2000.
abstract: BACKGROUND
  Epidemiologic data for multiple sclerosis (MS) in Olmsted County, MN, have been recorded for almost 100 years and have indicated that the increasing prevalence rate was likely due in part to an increasing incidence rate.
  
  
  METHODS
  All cases of MS diagnosed from 1985 to 2000 were identified using the centralized diagnostic index at the Mayo Clinic and the Rochester Epidemiology Program Project, a shared database of all medical practitioners in the county. Patients were required to have established residency at least 1 year prior to diagnosis of MS. Results were also age- and sex-adjusted to control for shifts in the population structure.
  
  
  RESULTS
  The raw prevalence of MS was determined to be 177 per 100,000 on December 1, 2000, and the raw incidence rate was 7.5 per 100,000 person-years at risk from 1985 to 2000.
  
  
  CONCLUSIONS
  After age and sex adjustment to a common population, these prevalence and incidence rates of MS appear to have been stable rather than increasing over the past 20 years.
authors.affiliation: Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: W T
authors.initials: WT
authors.lastname: Mayr
authors.forename: S J
authors.initials: SJ
authors.lastname: Pittock
authors.forename: R L
authors.initials: RL
authors.lastname: McClelland
authors.forename: N W
authors.initials: NW
authors.lastname: Jorgensen
authors.forename: J H
authors.initials: JH
authors.lastname: Noseworthy
authors.forename: M
authors.initials: M
authors.lastname: Rodriguez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence