title: [Effect of intravenous administration of monoantibody to P-selectin on the distribution of ACC-M adhesion in lung].
abstract: OBJECTIVE
  To investigate the effect of intravenous administration of monoantibody to P-selectin (PS1) on the lung-metastasis characteristic of highly lung metastatic adenoid cystic carcinoma cell strain (ACC-M).
  
  
  METHODS
  3HTdR labeled ACC-M cells were injected intravenously through tail vein after using monoantibody to P-selectin. A mice of each group were killed at 2 h, 6 h and 18 h after infusion, respectively. The relative radioactivity (CPM) in the lung and liver was detected.
  
  
  RESULTS
  3H-activity per gram in lung of mAb group was lower than in control group. There was significant difference between the two groups (P < 0.001). There was no difference between the two groups of liver tissues (P > 0.005).
  
  
  CONCLUSIONS
  The results of this study suggested that the highly lung metastasis characteristic of ACC-M may be partially inhibited by the use of monoantibody to the P-selectin.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Stomatology, Shanghai Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.
authors.forename: Xin-jun
authors.initials: XJ
authors.lastname: Wang
authors.forename: Wan-tao
authors.initials: WT
authors.lastname: Chen
authors.forename: Yang
authors.initials: Y
authors.lastname: Yu
authors.forename: Xiao-jian
authors.initials: XJ
authors.lastname: Zhou
authors.forename: Qin
authors.initials: Q
authors.lastname: Xu
authors.forename: Dian-cai
authors.initials: DC
authors.lastname: Cai
mesh_terms: D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology / Q000628:therapy*; D002448:Cell Adhesion; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary*; D051379:Mice; D008819:Mice, Nude; D019007:P-Selectin / Q000276:immunology / Q000502:physiology*
chemical_list: D000906:Antibodies; D019007:P-Selectin