title: Effect of micronized fenofibrate on vascular endothelial function in patients with hypertriglyceridemia.
abstract: OBJECTIVE
  To investigate the effect of micronized fenofibrate on vascular endothelial function in patients with hypertriglyceridemia.
  
  
  METHODS
  Using high-resolution ultrasound, we measured flow- and nitroglycerin-induced dilatation of the brachial artery in 30 patients with hypertriglyceridemia before and after treatment with micronized fenofibrate at a dose of 200 mg once daily for 4 weeks. Simultaneously, both serum lipid and plasma endothelin (ET) levels were determined.
  
  
  RESULTS
  After micronized fenofibrate therapy, serum triglyceride (TG) levels decreased significantly (P < 0.05). Plasma ET levels also decreased markedly [(82.66 +/- 15.46) microg/L vs. (106.22 +/- 19.16) microg/L, P < 0.001]. Flow-induced vasodilatation was much improved (11.0% +/- 9.0% vs 2.7% +/- 2.0%, P < 0.01). However, no significant changes in vasodilatation occurred in response to nitroglycerin (16.2% +/- 6.0% vs 15.0% +/- 5.0%, P > 0.05) in patients with hypertriglyceridemia.
  
  
  CONCLUSIONS
  Micronized fenofibrate can improve impaired endothelium-dependent vasodilatation in patients with hypertriglyceridemia. Improving endothelial function may also be the mechanism responsible for the beneficial effects of micronized fenofibrate.
authors.affiliation: Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. huangyun1207@163.com
authors.forename: Yun
authors.initials: Y
authors.lastname: Huang
authors.forename: Guizhu
authors.initials: G
authors.lastname: Dai
authors.forename: Zongchen
authors.initials: Z
authors.lastname: Feng
authors.forename: Chengfa
authors.initials: C
authors.lastname: Lu
authors.forename: Bei
authors.initials: B
authors.lastname: Cheng
authors.forename: Qiufen
authors.initials: Q
authors.lastname: Wang
authors.forename: Fuding
authors.initials: F
authors.lastname: Nie
authors.forename: Jingdong
authors.initials: J
authors.lastname: Li
mesh_terms: D000328:Adult; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D005260:Female; D011345:Fenofibrate / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014664:Vasodilation / Q000187:drug effects
chemical_list: D011345:Fenofibrate