title: Caspofungin activity against clinical isolates of fluconazole-resistant Candida.
abstract: A total of 7,837 clinical isolates of Candida were tested against fluconazole, and 351 resistant (fluconazole MIC >/=64 micro g/ml) isolates were identified (4% of the total tested). All fluconazole-resistant isolates were inhibited by caspofungin at concentrations that can be exceeded by standard doses (MIC at which 90% of the isolates were inhibited, 1 micro g/ml; 99% of the MICs were </=2 micro g/ml).
authors.affiliation: Departments of Pathology, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa 52242, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Pfaller
authors.forename: Shawn A
authors.initials: SA
authors.lastname: Messer
authors.forename: Linda
authors.initials: L
authors.lastname: Boyken
authors.forename: Cassie
authors.initials: C
authors.lastname: Rice
authors.forename: Shailesh
authors.initials: S
authors.lastname: Tendolkar
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Hollis
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Diekema
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification; D041221:Candida glabrata / Q000187:drug effects / Q000302:isolation & purification; D000077336:Caspofungin; D004352:Drug Resistance, Microbial / Q000502:physiology*; D054714:Echinocandins; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000494:pharmacology*; D010456:Peptides, Cyclic
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010455:Peptides; D010456:Peptides, Cyclic; D015725:Fluconazole; D000077336:Caspofungin