Biologic strategies for the therapy of intervertebral disc degeneration.
Recent advances in tissue engineering have led to promising new approaches for the biologic treatment of disc degeneration. At present, there is no effective therapy for disc degeneration, a condition which results in large healthcare and socio-economic costs. This article will examine the current approaches used in biologic therapies for disc degeneration, including cell-based tissue engineering, gene therapy and the application of mesenchymal stem cells, and discuss their therapeutic potential, as demonstrated in animal models and experimental studies to date.
Gruber
Helen E
HE
Department of Orthopaedic Surgery, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232, USA. helen.gruber@carolinashealthcare.org
Hanley
Edward N
EN
D000818:Animals; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007403:Intervertebral Disc / Q000473:pathology*; D008648:Mesoderm / Q000166:cytology; D013122:Spinal Diseases / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods*