[Effect of acetylsalicylic and mefenamic acids on cytoarchitectonic of skin in rats with acute local cryogenic trauma].
The effect of acetylsalicylic (250 mg/kg) and mephenamic (50 mg/kg) acids on the process of skin cytoarchitectonics restoration was studied in rats with acute local cryogenic traumas induced by acting with a stream of ethyl chloride upon epilated back skin area (1.5 cm2). The animals were killed under narcosis on the 12th day of post-treatment observation. Both acetylsalicylic and mephenamic acids were administered per os twice per day over various periods after cryogenic damage. The effect depended on the treatment duration. The normal skin cytoarchitectonics was restored by acetylsalicylic acid in half, and by mephenamic acid, in one-third of cases (for a "combined" administration scheme).
Nazarenko
N A
NA
Department of Pharmacology, Archangelsk State Medical Academy, Troitskii pr. 51, Archangelsk, 163051 Russia.
Khodasevich
L S
LS
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005627:Frostbite / Q000188:drug therapy*; D008297:Male; D008528:Mefenamic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008528:Mefenamic Acid; D001241:Aspirin