title: Intrauterine cerebral infarcts and bilateral frontal cortical leukomalacia following chronic maternal inhalation of carburetor cleaning fluid during pregnancy.
abstract: Little is known about the effect of inhalation of methanol and other solvents on the pregnancy and the growth of the fetus. We report a preterm male infant who developed cerebral infarcts in utero, leading to large areas of bilateral frontal cortical leukomalacia following chronic maternal inhalation of carburetor-cleaning fluid during pregnancy. The infant presented with acute fetal distress with significant metabolic acidosis at birth. Initial hypotonia was followed by generalized hypertonicity. This infant did not exhibit typical facial features of fetal alcohol syndrome.
authors.affiliation: Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA.
authors.forename: Des
authors.initials: D
authors.lastname: Bharti
mesh_terms: D000096:Acetone / Q000009:adverse effects; D000138:Acidosis / Q000139:chemically induced; D002544:Cerebral Infarction / Q000139:chemically induced*; D004338:Drug Combinations; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000139:chemically induced*; D007969:Leukomalacia, Periventricular / Q000139:chemically induced* / Q000000981:diagnostic imaging; D008297:Male; D000432:Methanol / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012997:Solvents / Q000009:adverse effects*; D019966:Substance-Related Disorders / Q000150:complications*; D014050:Toluene / Q000009:adverse effects; D014463:Ultrasonography
chemical_list: D004338:Drug Combinations; D012997:Solvents; D000096:Acetone; D014050:Toluene; D000432:Methanol