Interleukin-1A (-889) genetic polymorphism increases the risk of multiple system atrophy.
In a case-control study using a clinically well-defined group of 30 multiple system atrophy (MSA) patients and 110 control subjects, homozygosity for interleukin-1A (IL-1A) allele 2 (high secretor of proinflammatory cytokine) in the regulatory region (-889) of the IL-1A gene was associated with a fivefold increased risk for MSA.
Combarros
Onofre
O
Neurology Service, University Hospital Marqués de Valdecilla, University of Cantabria, Santander, Spain. combarro@unican.es
Infante
Jon
J
Llorca
Javier
J
Berciano
José
J
D000328:Adult; D000368:Aged; D005260:Female; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000235:genetics* / Q000276:immunology*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors
D007375:Interleukin-1