title: Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples.
abstract: Knowledge of genetic polymorphisms in gene-environment studies may contribute to more accurate identification of avoidable risks and to developing tailor-made preventative measures. The aim of this study was to describe the allele frequencies of single nucleotide polymorphisms (SNPs) of select genes, which may be included in future gene-environment studies on cancer in Japan. SNP typing was performed on middle-aged Japanese men randomly selected from the general population in five areas of Japan. We genotyped and calculated allele frequencies of 153 SNPs located on 40 genes: CYP1A1, CYP1B1, CYP2C9, CYP2C19, CYP2E1, CYP17A1, CYP19A1, AHR, ESR1, ESR2, ERRRG, PGR, EPHX1, EPHX2, HSD17B2, HSD17B3, GSTM2, GSTM3, GSTT2, GSTP1, NAT1, NAT2, COMT, ADH1A, ADH1B, ADH1C, ALDH2, NOS2A, NOS3, IL1A, IL1B, OGG1, NUDT1 [MTH1], DRD2, DRD3, DRD4, SLC6A4, NR3C1 [GCCR], MTHFR, and NQO1. In the present study, the Japanese allele frequencies were verified by using nationwide population samples.
authors.affiliation: Cancer Information and Epidemiology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. kyoshimu@ncc.go.jp.
authors.forename: Kimio
authors.initials: K
authors.lastname: Yoshimura
authors.affiliation: Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Chiba, Japan.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Hanaoka
authors.affiliation: Genetics Division, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: Shumpei
authors.initials: S
authors.lastname: Ohnami
authors.affiliation: Genetics Division, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: Sumiko
authors.initials: S
authors.lastname: Ohnami
authors.affiliation: Biology Division, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kohno
authors.affiliation: Cancer Information and Epidemiology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Genetics Division, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Yoshida
authors.affiliation: Genetics Division, National Cancer Center Research Institute, Tokyo, Japan.
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sakamoto
authors.affiliation: Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Chiba, Japan.
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Tsugane
mesh_terms: D000483:Alleles; D000596:Amino Acids / Q000737:chemistry; D004247:DNA / Q000032:analysis; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007564:Japan; D009369:Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011897:Random Allocation
chemical_list: D000596:Amino Acids; D004247:DNA