title: Preventing mother-to-child HIV transmission in a developing country: the Dominican Republic experience.
abstract: Transmission of HIV in the Dominican Republic occurs primarily through heterosexual contact. As part of a continuing strategy to prevent and contain the spread of HIV infection, the Ministry of Health of the Dominican Republic established an integrated package of interventions to reduce HIV mother-to-child transmission that was initiated on May 15, 2000. The program was designed to be implemented in 3 phases. The 1st phase included 4 mother and child hospitals; the 2nd phase included 8 mother and child health institutions in Santo Domingo, the capital of the Dominican Republic, and 7 additional mother and child hospitals. The 3rd phase will include the remaining 12 mother and child health care institutions of the Dominican Republic. Evaluation of the 1st year of this program, involving 8 hospitals and >40000 pregnant women, identified specific benefits and limitations. Low numbers of voluntary counseling sessions (6528/42666 = 28%) and inadequate number of HIV rapid tests (23067/42666 = 54%) were the 2 main obstacles encountered. From the 23067 pregnant women tested, 581 (2.5%) were HIV positive. Advantageous aspects included the successful administration of antiretroviral treatment to 89% (164/185) of the mothers and 98% (183/186) of the children. Cesarean section was performed in 67% (124/185) of the HIV-positive pregnant women, and infant formula was dispensed to 47% (87/186) of all cases. These findings demonstrate the feasibility of implementing a large-scale program to prevent mother-to-child transmission in a developing country.
authors.affiliation: National Research Center on Maternal and Child Health (CENISMI), Santo Dominican Republic. ept26@yahoo.com
authors.forename: Eddy
authors.initials: E
authors.lastname: Perez-Then
authors.forename: Ricarda
authors.initials: R
authors.lastname: Peña
authors.forename: Maria
authors.initials: M
authors.lastname: Tavarez-Rojas
authors.forename: Cleotilde
authors.initials: C
authors.lastname: Peña
authors.forename: Salvador
authors.initials: S
authors.lastname: Quiñonez
authors.forename: Marta
authors.initials: M
authors.lastname: Buttler
authors.forename: Arthur
authors.initials: A
authors.lastname: Ammann
authors.forename: William
authors.initials: W
authors.lastname: Hernández
authors.forename: Miguel
authors.initials: M
authors.lastname: Goyanes
authors.forename: Maria Jose
authors.initials: MJ
authors.lastname: Miguez
authors.forename: Gail
authors.initials: G
authors.lastname: Shor-Posner
mesh_terms: D001903:Bottle Feeding; D036861:Delivery, Obstetric; D003906:Developing Countries; D004293:Dominican Republic; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D019829:Nevirapine / Q000627:therapeutic use*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control / Q000821:virology*; D011256:Pregnancy Outcome; D011295:Prenatal Care; D019562:Viral Load
chemical_list: D017320:HIV Protease Inhibitors; D019829:Nevirapine