Activity of combinations of ceftazidime, imipenem and pefloxacin against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa.
The chequerboard technique was used to look for synergistic combinations of ceftazidime, imipenem and pefloxacin. The synergistic combinations were used in vivo in mice experimentally infected with Escherichia coli, Salmonella typhimurium and Pseudomonas aeruginosa. In vitro ceftazidime/imipenem, ceftazidime/pefloxacin and pefloxacin/imipenem combinations showed synergistic effects against Staphylococcus aureus and S. typhimurium and additive effects against P. aeruginosa. Only the ceftazidime/pefloxacin combination was synergistic against E. coli while the ceftazidime/imipenem and pefloxacin/imipenem combinations resulted in additive effects. In vivo, combination of ceftazidime/imipenem against E. coli infection and the pefloxacin/imipenem combination against S. typhimurium infection were protective.
El-Sukhon
Saeb Nazmi
SN
Faculty of Veterinary Medicine, Jordan University of Science and Technology, PO Box 3030, Irbid, Jordan. sukhon@just.edu.jo
Faiza Boukhatem
Zineb
Z
D000818:Animals; D002442:Ceftazidime / Q000008:administration & dosage*; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000008:administration & dosage*; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000188:drug therapy; D015378:Imipenem / Q000008:administration & dosage*; D066298:In Vitro Techniques; D051379:Mice; D008826:Microbial Sensitivity Tests; D015366:Pefloxacin / Q000008:administration & dosage*; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects*
D015366:Pefloxacin; D015378:Imipenem; D002442:Ceftazidime