The nitroreductase/CB1954 enzyme-prodrug system.
Green
Nicola K
NK
Hybrid Systems Ltd., Littlemore Park, Oxford, UK.
Kerr
David J
DJ
Mautner
Vivien
V
Harris
Peter A
PA
Searle
Peter F
PF
D016475:3T3 Cells; D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000633:toxicity; D001388:Aziridines / Q000493:pharmacokinetics* / Q000633:toxicity; D001711:Biotransformation; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D005260:Female; D041722:Genes, Transgenic, Suicide; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D007668:Kidney; D051379:Mice; D008819:Mice, Nude; D009601:Nitroreductases / Q000235:genetics* / Q000378:metabolism*; D010051:Ovarian Neoplasms; D011355:Prodrugs / Q000493:pharmacokinetics*; D014407:Tumor Cells, Cultured; D010948:Viral Plaque Assay
D000970:Antineoplastic Agents; D001388:Aziridines; D011355:Prodrugs; C100099:tretazicar; D009601:Nitroreductases