HCV prevalence in Hodgkin and non-Hodgkin lymphoma cases.
OBJECTIVE
In this study we aimed to investigate the relation between hepatitis C virus (HCV) and B cell lymphoproliferative diseases.


METHODS
Eighty-four patients with B-cell non-Hodgkin lymphoma and 50 patients with Hodgkin lymphoma were included. Control group consisted of another 100 otherwise healthy blood donors who had no previous history of invasive surgery, blood transfusions, and viral hepatitis. HCV positivity was investigated in both case groups and control group.


RESULTS
Anti-HCV positivity was significantly more frequent in B-cell non-Hodgkin lymphoma patients compared to control group (7.1% vs. 1%, p<0.05). In Hodgkin lymphoma patients however, frequency was comparable with the control group (2% vs. 1%, p<0.05).


CONCLUSIONS
These findings suggest that HCV may play a role in the development of B-cell non-Hodgkin lymphoma, but not in Hodgkin lymphoma.
Yenice
Necati
N
Department of Internal Medicine 3rd Section, SSK Okmeydani Training Hospital, Istanbul, Turkey. netyayincilik@turk.net
Güllük
Fatih
F
Arican
Nurten
N
Türkmen
Sembol
S
D000328:Adult; D017677:Age Distribution; D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D015897:Comorbidity; D005260:Female; D016174:Hepacivirus / Q000302:isolation & purification*; D006526:Hepatitis C / Q000175:diagnosis / Q000453:epidemiology*; D006689:Hodgkin Disease / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012016:Reference Values; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D014421:Turkey / Q000453:epidemiology