title: Spontaneous regression of severe acquired infantile hypothyroidism associated with multiple liver hemangiomas.
abstract: A 9-week-old infant presented with severe postnatal hypothyroidism. His hypothyroidism corrected only after his L-thyroxine dose was progressively increased to 28 micro g/kg/d. At 6 months of age, multiple clinically asymptomatic hepatic hemangiomas were detected and support a diagnosis of consumptive hypothyroidism as a result of increased type 3 iodothyronine deiodinase activity in the hemangiomas. Coincident with the involution of the hemangiomas, the child's hypothyroidism improved and L-thyroxin replacement could be stopped at the age of 3 years. Despite some degree of hypothyroidism for several weeks during infancy, his growth and development have been normal.
authors.affiliation: Division of Endocrinology, The Hospital for Sick Children, University of Toronto, Ontario, Canada.
authors.forename: Daniel
authors.initials: D
authors.lastname: Konrad
authors.forename: Graham
authors.initials: G
authors.lastname: Ellis
authors.forename: Kusiel
authors.initials: K
authors.lastname: Perlman
mesh_terms: D006391:Hemangioma / Q000150:complications* / Q000503:physiopathology; D020249:Hormone Replacement Therapy; D006801:Humans; D007037:Hypothyroidism / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D007223:Infant; D008113:Liver Neoplasms / Q000150:complications* / Q000503:physiopathology; D008297:Male; D012075:Remission, Spontaneous; D013963:Thyroid Hormones / Q000627:therapeutic use
chemical_list: D013963:Thyroid Hormones