[Clinical characteristics and genetic analysis of rare chromosome aberration in peripheral blood].
OBJECTIVE
To investigate the main clinical characteristics and genetic analysis of rare chromosome aberration in peripheral blood.


METHODS
Peripheral blood cells were cultured for 72 hours with routine method and slids performed, and then the slide was read and mode analysis was carried out. The diagnostic standard of rare chromosomal aberation was: 1-2 abnormal kary types were found in every 30, 60, 200 mitotic phass.


RESULTS
The main clinical characteristics of 52 cases of individual chromosomal aberation in peripheral blood included: 1. spontaneous abortion; 2. abnormal sex development; 3. reproduction diseases; and 4. morbid and deformity.


CONCLUSIONS
Rare chromosomal aberation should be regarded as chromosomal diseases. Prenatal diagnosis is necessary for people with such chromosomal aberation in their reproductive actions.
Chen
Sheng-xiang
SX
Hunan Reproduction Engineering Research Institute, Xiangya School of Medicine, Central South University, Changsha 410008, China.
Liu
Li
L
Wu
Han-wen
HW
D000026:Abortion, Habitual / Q000235:genetics; D000293:Adolescent; D000328:Adult; D001773:Blood Cells / Q000166:cytology; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders / Q000235:genetics; D020732:Cytogenetic Analysis; D005260:Female; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged