[Study on the relationship between changes of adrenomedulin in plasma and vascular resistance during traumatic shock in rats].
OBJECTIVE
To observe the changes of adrenomedulin in plasma and vascular resistance during traumatic shock in rats.


METHODS
The concentration of adrenomedulin in plasma of rats after traumatic shock was detected by radio immunization. Mean arterial pressure, total peripheral vascular resistance (TPVR) and cardiac index (CI) were estimated by electrical conductance method.


RESULTS
The concentration of adrenomedulin in plasma of traumatic shock without resuscitation group (68.34+/-3.71)ng/L and traumatic shock with resuscitation group (146.27+/-9.83)ng/L were higher than that of control group(32.63+/-7.55)ng/L (P<0.01 and P<0.05). TPVR of traumatic shock with resuscitation group (10.57+/-0.35) kPa.s.L-1 was lower than that of traumatic shock without resuscitation group (16.75+/-0.23) kPa.s.L-1(P<0.01) and its CI (215.59+/-1.29) ml.min-1.kg-1 was higher than that of traumatic shock without resuscitation group (143.11+/-0.86) ml.min-1.kg-1 (P<0.01).


CONCLUSIONS
Adrenomedulin is closely correlated with changes of vascular resistance and plays an important role during pathophysiological processes in rats after traumatic shock.
Sun
Gao-bin
GB
Department of General Surgery, First Military Medical University, Guangzhou 510280, Guangdong, China.
Huang
Zong-hai
ZH
Li
Zhou
Z
Song
Hui-juan
HJ
Tao
Wei-guo
WG
Long
Jun
J
D053607:Adrenomedullin; D000818:Animals; D001794:Blood Pressure; D005260:Female; D008297:Male; D010455:Peptides / Q000097:blood*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012774:Shock, Traumatic / Q000097:blood* / Q000503:physiopathology; D014655:Vascular Resistance
D010455:Peptides; D053607:Adrenomedullin