Effect of the PercuSurge GuardWire device on the integrity of microvasculature and clinical outcomes during primary transradial coronary intervention in acute myocardial infarction.
The present study investigates whether preintervention thrombectomy with a PercuSurge distal balloon protection device can improve final angiographic results compared with adjunctive tirofiban therapy during primary percutaneous coronary intervention (PCI) in large infarct-related arteries (IRAs) (vessel size >/=3.5 mm) with high-burden thrombus formation (HBTF). Results indicate that this mechanical device is superior to adjunctive tirofiban therapy during primary PCI in large IRAs with HBTF in terms of final epicardial flow, microvasculature integrity, and 30-day clinical outcomes.
Yip
Hon-Kan
HK
Division of Cardiology and the Department of Pathology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Wu
Chiung-Jen
CJ
Chang
Hsueh-Wen
HW
Fang
Chih-Yuan
CY
Yang
Cheng-Hsu
CH
Chen
Shyh-Ming
SM
Hung
Wei-Chin
WC
Chen
Chien-Jen
CJ
Cheng
Cheng-I
CI
Hsieh
Yuan-Kai
YK
D015906:Angioplasty, Balloon, Coronary; D016009:Chi-Square Distribution; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology; D003328:Coronary Thrombosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000502:physiology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D018709:Statistics, Nonparametric; D017131:Thrombectomy / Q000295:instrumentation*; D000077466:Tirofiban; D016896:Treatment Outcome; D014443:Tyrosine / Q000008:administration & dosage / Q000031:analogs & derivatives*
D005343:Fibrinolytic Agents; D014443:Tyrosine; D000077466:Tirofiban