Ovariectomy aggravates nifedipine-induced flushing of tail skin in mice.
Flushing is one of the most common vasodilation-related adverse effects associated with Ca(2+) channel antagonist treatment. This symptom is known to occur more frequently in women than men. The present study aimed at investigating the effect of ovariectomy on nifedipine-induced flushing in mice. Ovariectomy markedly increased the tail skin temperature, a parameter of skin flushing, induced by nifedipine at a dose showing no influence on blood pressure. This event was blocked by estradiol replacement. Estrogen withdrawal is, therefore, included in the risk factors for nifedipine-induced flushing and this risk is lessened by estrogen replacement.
Kai
Mamiko
M
Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan, Fukuoka 814-0180, Japan.
Tominaga
Koji
K
Okimoto
Kisaragi
K
Yamauchi
Atsushi
A
Kai
Hisashi
H
Kataoka
Yasufumi
Y
D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005483:Flushing / Q000209:etiology*; D051379:Mice; D008813:Mice, Inbred ICR; D009543:Nifedipine / Q000494:pharmacology*; D010052:Ovariectomy / Q000009:adverse effects*; D012867:Skin / Q000098:blood supply / Q000187:drug effects* / Q000503:physiopathology; D012881:Skin Temperature / Q000187:drug effects; D013623:Tail; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; D004958:Estradiol; D009543:Nifedipine