Hemimegalencephaly with tuberous sclerosis: a longitudinal imaging study.
Hemimegalencephaly is a rare cerebral malformation characterized by asymmetry of the hemispheres and cortical dysplasias. We report clinical and imaging findings in a child with hemimegalencephaly involving the right cerebral hemisphere with associated manifestations of tuberous sclerosis complex. Gross abnormal myelination pattern and gyral abnormalities were seen in the enlarged hemisphere. Subsequent scans showed atrophy of the frontoparietal region in the enlarged hemisphere and normal growth of the opposite hemisphere exceeding the size of the abnormal hemisphere in the frontoparietal region. A few white-matter lesions that were seen in the normal hemisphere on neonatal scan were difficult to appreciate on subsequent MR studies. The white-matter lesions were better seen in the neonatal period, whereas cortical tubers were better detected at a later age.
Parmar
Hemant
H
Department of Radiology, King Edward VII Memorial Hospital, Bombay, India. parurad@hotmail.com
Patkar
Deepak
D
Shah
Jeshil
J
Patankar
Tufail
T
D002540:Cerebral Cortex / Q000002:abnormalities* / Q000473:pathology; D003937:Diagnosis, Differential; D006801:Humans; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D014402:Tuberous Sclerosis / Q000175:diagnosis* / Q000473:pathology