title: Onset of hepatic erythropoiesis after malarial infection in mice.
abstract: Plasmodium yoelii-infected erythrocytes were injected into mice with or without 6.5 Gy irradiation. This irradiation suppressed erythropoiesis and induced severe immunosuppression. However, these mice showed a rather delayed infection, suggesting that fresh erythrocytes may become malarial targets. In other words, malarial infection did not persist without newly generated erythrocytes in mice. We then examined erythropoiesis in the liver and bone marrow of mice with malaria. Surprisingly, erythropoiesis began in the liver. At this time, the serum level of erythropoietin (EPO) was prominently elevated and the EPO mRNA also became detectable in the kidney. Many clusters of red blood cells appeared de novo in the parenchymal space of the liver. These results revealed that malarial infection had a potential to induce the onset of hepatic erythropoiesis in mice.
authors.affiliation: Department of Immunology, Niigata University School of Medicine, Niigata 951-8510, Japan.
authors.forename: Ramesh C
authors.initials: RC
authors.lastname: Halder
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Abe
authors.forename: M Kaiissar
authors.initials: MK
authors.lastname: Mannoor
authors.forename: Sufi Reza M
authors.initials: SR
authors.lastname: Morshed
authors.forename: Anoja
authors.initials: A
authors.lastname: Ariyasinghe
authors.forename: Hisami
authors.initials: H
authors.lastname: Watanabe
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kawamura
authors.forename: Hiroho
authors.initials: H
authors.lastname: Sekikawa
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Hamada
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Ken
authors.initials: K
authors.lastname: Toba
authors.forename: Toru
authors.initials: T
authors.lastname: Abo
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004920:Erythropoiesis / Q000502:physiology*; D007150:Immunohistochemistry; D007963:Leukocytes, Mononuclear / Q000502:physiology; D008099:Liver / Q000473:pathology / Q000503:physiopathology*; D008288:Malaria / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018512:Parasitemia / Q000276:immunology / Q000503:physiopathology; D010967:Plasmodium yoelii; D012016:Reference Values; D013997:Time Factors