Fulminant liver failure induced by hepatosplenic alphabeta T-cell lymphoma.
Since survival rates of fulminant liver failure are low, early consideration of liver transplantation in patients developing hepatic encephalopathy due to progressive liver failure is mandatory. Rapid diagnostic work-up is necessary to identify the underlying disease and to rule out contraindications to liver transplantation. We report the case of a 35-year-old patient presenting with fulminant hepatitis and a four-week history of biopsy-proven autoimmune hepatitis. Despite high-dose steroid-treatment liver function progressively worsened and hepatic encephalopathy rapidly developed. Histopathologic evaluation of a liver biopsy specimen revealed necrotizing hepatitis and rare atypical lymphocytes. Surgical biopsy specimens confirmed the suspicion of an aggressive hepatosplenic alphabeta T-cell lymphoma which represents a contraindication to liver transplantation.
Petersen-Benz
C
C
Department of Gastroentrology, University Hospital of Cologne, Joseph-Stelzmann-Str. 9, 50 931 Cologne.
Hoffmann
N
N
Beckurts
T
T
Goeser
T
T
Steffen
H-M
HM
Dries
V
V
D000328:Adult; D001706:Biopsy; D006501:Hepatic Encephalopathy / Q000209:etiology / Q000401:mortality; D006505:Hepatitis / Q000473:pathology; D019693:Hepatitis, Autoimmune / Q000150:complications / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007813:Laparotomy; D008099:Liver / Q000473:pathology; D017093:Liver Failure / Q000209:etiology* / Q000401:mortality; D008113:Liver Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D008297:Male; D013154:Spleen / Q000473:pathology; D013160:Splenic Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology