title: Acute verbal dyspraxia, a rare presentation in multiple sclerosis: a case report with MRI localization.
abstract: Cortical speech disorders rarely occur in multiple sclerosis (MS). We report a patient with relapsing-remitting MS, who presented with acute verbal dyspraxia. Magnetic resonance imaging (MRI) demonstrated an acute T2/Flair hyperintense, primarily white matter lesion underlying the middle third of the inferior frontal gyrus. The verbal dyspraxia cleared beginning 48 hours after the initiation of iv dexamethasone. Follow-up MRI demonstrated qualitative and quantitative diminution of the hyperintensity. This is the first report of a clinically definite MS patient with acute verbal dyspraxia. Moreover, there was a suggestive localization of verbal praxis to Brodmann areas 44/45.
authors.affiliation: Department of Neurology, Louisiana State University School of Medicine Shreveport, 1501 Kings Highway, Shreveport, LA 71130, USA.
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Jaffe
authors.forename: Michael F
authors.initials: MF
authors.lastname: Glabus
authors.forename: Roger E
authors.initials: RE
authors.lastname: Kelley
authors.forename: Alireza
authors.initials: A
authors.lastname: Minagar
mesh_terms: D000208:Acute Disease; D000328:Adult; D001072:Apraxias / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D001921:Brain / Q000473:pathology; D003907:Dexamethasone / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone