title: Treatment of squamous cell carcinoma with intralesional 5-Fluorouracil.
abstract: BACKGROUND
  5-Fluorouracil (5-FU) has been used topically and intralesionally to treat lesions related to squamous cell carcinoma (SCC) such as actinic keratosis, Bowen's disease, and keratoacanthoma.
  
  
  OBJECTIVE
  We sought to determine whether intralesional 5-FU might be effective in treating a patient with SCC.
  
  
  METHODS
  A patient with SCC at the junction of the right alar crease and right nasolabial fold was treated with eight weekly injections of 5-FU, with doses ranging from 0.8 to 2.4 mL.
  
  
  RESULTS
  A repeat biopsy after the eighth treatment showed total clearance of the cancer, and the patient has remained free of recurrence during a 5-month follow-up period.
  
  
  CONCLUSIONS
  This modality may provide patients with SCC in cosmetically important locations or in areas that require complex surgery the advantage of a nonsurgical cure.
authors.affiliation: Department of Dermatology, Louisiana State University Health Sciences Center, 1542 Tulane Avenue, New Orleans, LA 70112, USA.
authors.forename: Lisa G
authors.initials: LG
authors.lastname: Morse
authors.forename: Christina
authors.initials: C
authors.lastname: Kendrick
authors.forename: Deirdre
authors.initials: D
authors.lastname: Hooper
authors.forename: Holly
authors.initials: H
authors.lastname: Ward
authors.forename: Edward
authors.initials: E
authors.lastname: Parry
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D005145:Face; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D008875:Middle Aged; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil