title: P-selectin and platelet-derived microparticles associated with monocyte activation markers in patients with pulmonary embolism.
abstract: Platelet activation markers (platelet-derived microparticles and P-selectin on activated platelets), chemokines (monocyte chemotactic peptide and regulated on activation normally T-cell expressed and secreted), and soluble markers (sP-selectin, sE-selectin, sVCAM-1, and sCD14) were measured and compared in patients with pulmonary embolism (PE). These substances are thought to participate in the pathogenesis of PE. Levels of all of the platelet activation markers, chemokines, and soluble markers were higher in the patients with PE than in normal controls. Levels of platelet activation markers were also significantly increased postoperatively after total knee arthroplasty. Anti-platelet therapy significantly inhibited the elevation of platelet activation markers after total knee arthroplasty. These findings suggest that antiplatelet therapy may be useful for PE-related interaction of platelets, leukocytes, and endothelial cells.
authors.affiliation: Department of Internal Medicine, Kansai Medical Kohri Hospital, Neyagawa, Osaka, Japan.
authors.forename: Norihito
authors.initials: N
authors.lastname: Inami
authors.forename: Shosaku
authors.initials: S
authors.lastname: Nomura
authors.forename: Hiraku
authors.initials: H
authors.lastname: Kikuchi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kajiura
authors.forename: Kohichi
authors.initials: K
authors.lastname: Yamada
authors.forename: Hisahito
authors.initials: H
authors.lastname: Nakamori
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Takahashi
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Tsuda
authors.forename: Makoto
authors.initials: M
authors.lastname: Hikosaka
authors.forename: Motoko
authors.initials: M
authors.lastname: Masaki
authors.forename: Toshiji
authors.initials: T
authors.lastname: Iwasaka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee / Q000009:adverse effects; D015415:Biomarkers / Q000032:analysis; D001792:Blood Platelets / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure; D016022:Case-Control Studies; D018925:Chemokines / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D021962:Membrane Microdomains; D008875:Middle Aged; D009000:Monocytes / Q000502:physiology*; D019007:P-Selectin / Q000032:analysis*; D010316:Particle Size; D015539:Platelet Activation; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011655:Pulmonary Embolism / Q000097:blood / Q000209:etiology*
chemical_list: D015415:Biomarkers; D018925:Chemokines; D019007:P-Selectin; D010975:Platelet Aggregation Inhibitors