A review of approaches to the analysis of 3-nitrotyrosine.
Our understanding of in vivo tyrosine nitration has been confounded by problems associated with the analytical approaches that have been employed to quantify 3-nitroyrosine (3-NT). Trace analysis is a demanding task under the best of circumstances, but 3-NT offers some special concerns. This review examines some of these concerns and discusses approaches to ensuring that carefully validated analytical data are generated.
Duncan
M W
MW
Biochemical Mass Spectrometry, University of Colorado Health Sciences Center, Denver 80262, USA. mark.duncan@uchsc.edu
D000818:Animals; D002849:Chromatography, Gas / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002853:Chromatography, Liquid / Q000379:methods; D004563:Electrochemistry; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000032:analysis*
C002744:3-nitrotyrosine; D014443:Tyrosine