CSF hypocretin-1 levels in restless legs syndrome.
CSF hypocretin-1 levels at 6 PM did not significantly differ between patients with restless legs syndrome (RLS) and control subjects as measured by direct radioimmunoassay and after acid extraction. The authors did not observe significant differences between early onset and late onset RLS. Hypocretin-1 levels did not correlate with RLS severity or polysomnographic measures. These results contrast with previous findings reporting significantly increased CSF hypocretin-1 in the late evening and mostly in early onset RLS.
Stiasny-Kolster
K
K
Department of Neurology, Philipps-University Marburg, Germany. stiasny@staff.uni-marburg.de
Mignot
E
E
Ling
L
L
Möller
J C
JC
Cassel
W
W
Oertel
W H
WH
D000328:Adult; D000368:Aged; D002352:Carrier Proteins / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D000068797:Orexins; D012148:Restless Legs Syndrome / Q000134:cerebrospinal fluid* / Q000175:diagnosis
D002352:Carrier Proteins; C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins