The hypertriglyceridemic waist phenotype among women.
BACKGROUND
Elevated plasma triglycerides (TG) and waist girth (hypertriglyceridemic waist (HTGW)) has been associated with elevated insulin, small dense low-density lipoprotein (sLDL) particles, and Apo B in men. The HTGW has not been reported for women and the effect of cardiorespiratory fitness ("fitness") on associations between HTGW and coronary risk factors is unknown.


OBJECTIVE
To determine the prevalence of HTGW and the influence of fitness on the relationship between HTGW and coronary risk among 137 healthy women (54+/-9 year; body mass index (BMI)=28+/-6 kg/m(2)).


METHODS
HTGW was defined as waist girth >88 cm and TG >150 mg/dl. The metabolic triad was defined as insulin >31 pmol/l, Apo B >69 mg/dl and LDL-C >84 mg/dl. Fitness was assessed with a maximal treadmill exercise test.


RESULTS
The sample prevalence of HTGW (n=15) was 11% (95% CI=5.7-16.0%). Apo B (P=0.04) and insulin (P=0.0001) increased across quintiles of waist girth, and LDL-C (P=0.004) increased across quintiles of TG. Metabolic triad prevalence was highest (67%, n=10) among HTGW women and lowest (22%, n=26) among non-HTGW women. A trend for higher coronary heart disease CHD risk factors was observed among HTGW compared with non-HTGW women. Among the HTGW group, a trend for lower CHD risk factors was observed among fit (>or=6.5 METs, n=7) versus unfit women (<6.5 METs, n=8). Sample size limitations prohibited meaningful tests of significant differences in CHD risk factors when stratified simultaneously on HTGW and fitness status.


CONCLUSIONS
HTGW is associated with increased coronary risk factors similarly among women as reported for men. Higher fitness may improve the CHD risk profile among women with HTGW.
LaMonte
Michael J
MJ
Division of Cardiology, LDS Hospital, 8th Ave. and C Street, University of Utah School of Medicine, Salt Lake City, UT 84143, USA. ldmlamon@ihc.com
Ainsworth
Barbara E
BE
DuBose
Katrina D
KD
Grandjean
Peter W
PW
Davis
Paul G
PG
Yanowitz
Frank G
FG
Durstine
J Larry
JL
D001055:Apolipoproteins B / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D001823:Body Composition / Q000235:genetics*; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D007328:Insulin / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D010641:Phenotype; D010809:Physical Fitness / Q000502:physiology; D015995:Prevalence; D012307:Risk Factors; D013223:Statistics as Topic; D014280:Triglycerides / Q000097:blood; D016387:Women's Health
D001055:Apolipoproteins B; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D014280:Triglycerides; D002097:C-Reactive Protein