Intracerebroventricular injection of muscimol, baclofen or nipecotic acid stimulates food intake in layer-type, but not meat-type, chicks.
This study was designed to compare the effects of muscimol (GABA(A) agonist), baclofen (GABA(B) agonist) and nipecotic acid (GABA uptake inhibitor) on food intake in two chicken strains (meat-type and layer-type chicks). The intracerebroventricular (ICV) injection of all GABA agents induced hyperphagia in layer-type chicks. However, in broiler chicks, there were similar tendencies with muscimol and nipecotic acid but not significantly different. Conversely, ICV injection of baclofen depressed feeding of broiler chicks. These results suggest that there are some differences in central GABAergic systems between these strains of chicks, but GABAergic systems have an important role in the regulation of food intake in neonatal chicks.
Bungo
Takashi
T
Laboratory of Animal Science, Department of Agrobiological Science, Faculty of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama 790-8566, Japan. bungo@agr.ehime-u.ac.jp
Izumi
Tomofumi
T
Kawamura
Kazuya
K
Takagi
Tomo
T
Ueda
Hiroshi
H
Furuse
Mitsuhiro
M
D000818:Animals; D000831:Animals, Newborn; D001418:Baclofen / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002645:Chickens / Q000145:classification; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D018755:GABA Agonists / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009118:Muscimol / Q000494:pharmacology*; D009557:Nipecotic Acids / Q000494:pharmacology*; D013045:Species Specificity
D018755:GABA Agonists; D009557:Nipecotic Acids; C030278:nipecotic acid; D009118:Muscimol; D001418:Baclofen