Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats.
3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") is a drug frequently used under hot conditions in nightclubs. In rats tested in the social interaction paradigm, greater prosocial effects of MDMA (5.0 mg/kg) were seen at a hot temperature (30 degrees C) relative to normal laboratory temperature (21 degrees C). In the intravenous drug self-administration paradigm, hot temperature (30 degrees C) increased the number of MDMA infusions (0.1, 0.3 or 1.0 mg/kg/infusion) self-administered by rats. Hot temperatures thus appear to affect both the social and reinforcing effects of MDMA.
Cornish
Jennifer L
JL
School of Psychology, University of Sydney, A19 NSW 2006, Australia.
Shahnawaz
Zeeshan
Z
Thompson
Murray R
MR
Wong
Suzanna
S
Morley
Kirsten C
KC
Hunt
Glenn E
GE
McGregor
Iain S
IS
D000818:Animals; D006358:Hot Temperature; D007398:Interpersonal Relations; D008297:Male; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012646:Self Administration
D018817:N-Methyl-3,4-methylenedioxyamphetamine