Diterpenoids from the stem barks of Croton robustus.
Three compounds were isolated from the stem barks of Croton robustus. Their structures were elucidated as trachyloban-19-oic acid, trachyloban-19-ol and poilaneic acid by spectroscopic analysis. Among them, trachyloban-19-ol and methyl trachyloban-19-oate exhibited weak cytotoxic activity against gastric carcinoma and colon carcinoma with ED50 of 9.2, 9.6 and 8.3, 9.1 microg/mL, respectively.
Ngamrojnavanich
Nattaya
N
Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkom University, Bangkok 10330, Thailand.
Tonsiengsom
Sorasaree
S
Lertpratchya
Preecha
P
Roengsumran
Sophon
S
Puthong
Songchan
S
Petsom
Amorn
A
D045744:Cell Line, Tumor; D029802:Croton; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems
D004224:Diterpenes; D010936:Plant Extracts