title: Fast-MAS total through-bond correlation spectroscopy using adiabatic pulses.
abstract: Pulse sequences consisting of adiabatic pulses for total through-bond correlation spectroscopy (TOBSY) under magic-angle spinning (MAS) are introduced. Above a certain threshold, the polarization transfer achieved with these sequences is largely insensitive to the amplitude and homogeneity of the radiofrequency field employed. An experimental transfer efficiency of up to 76% was achieved in a two-spin system using the sequence WiW9(24)(1) at a MAS frequency of 26.67 kHz. Applications to resonance assignments in the dipeptide L-Val-L-Phe and in the cyclic decapeptide antamanide are demonstrated.
authors.affiliation: Physical Chemistry, ETH Hoenggerberg, CH-8093 Zurich, Switzerland.
authors.forename: Edme H
authors.initials: EH
authors.lastname: Hardy
authors.forename: Andreas
authors.initials: A
authors.lastname: Detken
authors.forename: Beat H
authors.initials: BH
authors.lastname: Meier
mesh_terms: D000465:Algorithms; D002247:Carbon Isotopes; D003198:Computer Simulation; D004151:Dipeptides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009587:Nitrogen Isotopes; D010456:Peptides, Cyclic / Q000737:chemistry*; D012815:Signal Processing, Computer-Assisted; D013113:Spin Labels; D013223:Statistics as Topic
chemical_list: D002247:Carbon Isotopes; D004151:Dipeptides; D009587:Nitrogen Isotopes; D010456:Peptides, Cyclic; D013113:Spin Labels; C420709:phenylalanyl-valine; C100265:antamanide