Tau phosphorylation, tangles, and neurodegeneration: the chicken or the egg?
Pathological aggregation of the microtubule-associated protein tau is a common feature of many neurodegenerative diseases. Although tau aggregation is associated with abnormal tau phosphorylation, the role of phosphorylation in the initiation of neurodegeneration has been unclear. Now, several animal models and data from human patients provide converging evidence that aberrant tau phosphorylation can cause a neurodegenerative phenotype similar to that seen in human neurodegenerative diseases.
Geschwind
Daniel H
DH
The Neuropsychiatric Institute, David Geffen School of Medicine, University of California, Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095, USA. dhg@ucla.edu
D000818:Animals; D001921:Brain / Q000378:metabolism; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D009410:Nerve Degeneration / Q000378:metabolism*; D016874:Neurofibrillary Tangles / Q000378:metabolism*; D010766:Phosphorylation; D016875:tau Proteins / Q000378:metabolism*
D016875:tau Proteins; D018844:Cyclin-Dependent Kinases