[Systemic infection of Aspergillus flavus in a patient with acute lymphoblastic leukemia].
A 57-year-old woman with acute lymphoblastic leukemia (ALL) developed an antibiotics-resistant fever after remission induction therapy. Chest X-ray and computed tomography scan revealed multiple consolidations and cavities. Successively, numerous subcutaneous nodules and a thyroid mass emerged. Aspergillus flavus (A. flavus) was cultured from both sites. Despite the patient's granulocyte recovery, the fever persisted and multiorgan function deteriorated rapidly. However, she was successfully treated with intensive supportive therapy including continuous hemodialysis and filtration. Prolonged use of amphoterin B and itraconazole failed to cure her aspergillosis, but the illness remained indolent thereafter.
Narimatsu
Hiroto
H
Department of Hematology and Oncology, JA Aichi Showa Hospital, Konan.
Morishita
Yoshihisa
Y
Kohno
Akio
A
Saito
Shigeki
S
Shimada
Kazuyuki
K
Ozeki
Kazutaka
K
Funahashi
Keiji
K
Kato
Yukio
Y
D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D001228:Aspergillosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D001231:Aspergillus flavus; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000473:pathology
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B