[Phagocytosis of polymer microspheres immobilized with bioligands by peripheral blood leukocytes in patients with acute pancreatitis].
Phagocytosis of polymer microspheres both modified and unmodified by bioligands (gelatin, fibronectin and A protein) by leukocytic blood cells of patients with acute pancreatitis. The presence of bioligands in the surface of polymer microspheres and their activity were monitored by the reaction of latex agglutination with an appropriate ligand being involved. The study resulted in designing a method of phagocytosis implementation that can be used to evaluate the content of certain receptors in cellular membranes and, subsequently, to define the changed receptor cell apparatus caused by a disease. The nature of polymer microspheric bioligands immobilized to the surface was shown to influence significantly the activity of leukocytic blood cells.
Stanishevskiĭ
Ia M
IaM
Skopintsev
V B
VB
Kravtsov
E G
EG
Grigor'evskaia
I I
II
Bykov
V A
VA
Gritskova
I A
IA
D000208:Acute Disease; D005353:Fibronectins / Q000378:metabolism; D005780:Gelatin / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008024:Ligands; D008863:Microspheres; D009504:Neutrophils / Q000378:metabolism / Q000502:physiology*; D010195:Pancreatitis / Q000097:blood*; D010587:Phagocytosis / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D017469:Receptors, Fibronectin / Q000378:metabolism; D013205:Staphylococcal Protein A / Q000378:metabolism
D005353:Fibronectins; D008024:Ligands; D011956:Receptors, Cell Surface; D017469:Receptors, Fibronectin; D013205:Staphylococcal Protein A; D005780:Gelatin