title: Acanthamoeba keratitis as a complication of orthokeratology.
abstract: OBJECTIVE
  To present four cases of Acanthamoeba keratitis as a complication of orthokeratology.
  
  
  METHODS
  Observational case report.
  
  
  METHODS
  Four patients with Acanthamoeba keratitis had histories of overnight orthokeratology lens wear of 6 months to 2 years.
  
  
  RESULTS
  Three cases were diagnosed with Acanthamoeba keratitis by corneal scraping and one by confocal microscopy examination. The patients were treated with chlorhexidine, metronidazole, and neomycin sulfate, resulting in a rapid resolution of ocular inflammation.
  
  
  CONCLUSIONS
  Overnight wear of orthokeratology lenses may induce Acanthamoeba keratitis.
authors.affiliation: Department of Eye Microbiology, Beijing Institute of Ophthalmology, TongRen Hospital, Beijing, China. sunxuguang@yahoo.com
authors.forename: Sun
authors.initials: S
authors.lastname: Xuguang
authors.forename: Chen
authors.initials: C
authors.lastname: Lin
authors.forename: Zhang
authors.initials: Z
authors.lastname: Yan
authors.forename: Wang
authors.initials: W
authors.lastname: Zhiqun
authors.forename: Li
authors.initials: L
authors.lastname: Ran
authors.forename: Luo
authors.initials: L
authors.lastname: Shiyun
authors.forename: Jin
authors.initials: J
authors.lastname: Xiuying
mesh_terms: D000048:Acanthamoeba / Q000302:isolation & purification; D015823:Acanthamoeba Keratitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002710:Chlorhexidine / Q000627:therapeutic use; D003261:Contact Lenses / Q000009:adverse effects*; D003315:Cornea / Q000469:parasitology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D009216:Myopia / Q000628:therapy; D009355:Neomycin / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole; D009355:Neomycin; D002710:Chlorhexidine