beta-alanine dipeptides as MC4R agonists.
beta-Alanine derivative 2 (IC(50)=16 nM) and related compounds were found to be potent MC4R agonists.
Ruel
Réjean
R
Bristol-Myers Squibb Pharmaceutical Research Institute, 100 boul. de l'Industrie, Candiac, Quebec, Canada J5R 1J1. rejean.ruel@bms.com
Herpin
Timothy F
TF
Iben
Lawrence
L
Luo
Guanglin
G
Martel
Alain
A
Mason
Helen
H
Mattson
Gail
G
Poirier
Brigitte
B
Ruediger
Edward H
EH
Shi
Dan
D
Thibault
Carl
C
Yu
Guixue
G
Antal Zimanyi
Ildiko
I
Poindexter
Graham S
GS
Macor
John E
JE
D000818:Animals; D001665:Binding Sites; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D015195:Drug Design; D005247:Feeding Behavior / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D023421:Models, Animal; D008958:Models, Molecular; D044105:Receptor, Melanocortin, Type 4 / Q000819:agonists*; D013329:Structure-Activity Relationship; D015091:beta-Alanine / Q000493:pharmacokinetics / Q000494:pharmacology*
D004151:Dipeptides; D044105:Receptor, Melanocortin, Type 4; D015091:beta-Alanine