title: In vitro activity of tigecycline against Staphylococcus epidermidis growing in an adherent-cell biofilm model.
abstract: The activity of tigecycline against Staphylococcus epidermidis growing in an in vitro adherent-cell biofilm model was determined. Tigecycline minimum bactericidal concentrations (MBCs) ranged from 1 to 8 microg/ml for S. epidermidis growing in a biofilm of adherent cells, compared to MBCs of 0.12 to >32 microg/ml for freely growing cells. The killing activity of tigecycline against the adherent bacteria was at least fourfold better than that of vancomycin and daptomycin.
authors.affiliation: Infectious Disease Research, Wyeth, Pearl River, New York 10965, USA.
authors.forename: Pornpen
authors.initials: P
authors.lastname: Labthavikul
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Petersen
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Bradford
mesh_terms: D001422:Bacterial Adhesion; D018441:Biofilms; D015169:Colony Count, Microbial; D003470:Culture Media; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011134:Polysaccharides / Q000378:metabolism; D013212:Staphylococcus epidermidis / Q000187:drug effects* / Q000254:growth & development; D000078304:Tigecycline
chemical_list: D003470:Culture Media; D011134:Polysaccharides; D000078304:Tigecycline; D008911:Minocycline