Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients.
Reduced levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are associated with deteriorated cognitive performance in senescence. Little work has been done on the effect of GH and IGF-1 on a crucial aspect of cognition, selective attention. This study investigated the effect of GH/IGF-1 on performance and brain potentials (EEG) during a selective-attention task in patients with low levels of GH and IGF-1 (childhood-onset growth hormone deficiency) compared to healthy controls. Detection of occasional visual target patterns was impaired in patients. This was paralleled by a reduction in an attention-related brain potential, which has been associated previously with anterior cingulate cortex functioning.
Lijffijt
M
M
Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands. m.lijffijt@pharm.uu.nl
Van Dam
P S
PS
Kenemans
J L
JL
Koppeschaar
H P F
HP
de Vries
W R
WR
Drent
M L
ML
Wittenberg
A
A
Kemner
C
C
D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D005071:Evoked Potentials; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000172:deficiency*; D008297:Male; D010364:Pattern Recognition, Visual / Q000502:physiology; D010775:Photic Stimulation
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I