title: [Simultaneous presence of macroamylase and macrolipase in a patient with celiac disease].
abstract: Celiac disease is a permanent intolerance to ingested gluten that results in immunologically mediated inflammatory damage of the small intestinal mucosa. Here we report the case of a patient with Celiac disease demonstrating simultaneous macroamylasemia and macrolipasemia. The patient showed persistently elevated levels of serum amylase and lipase. Amylase and lipase in normal serum were eluted from a Superdex-200 column after the 4S protein. These enzymes in the serum from this patient were eluted in the 19S protein. This finding indicated that these enzymes from this patient had a molecular weight greater than that of normal amylase and lipase. Immunoprecipitation assay showed that amylase was bound to polyclonal IgG and IgA, whereas lipase was bound to polyclonal IgA. To our knowledge, the simultaneous presence of macroamylase and macrolipase in the same patient has been previously reported in only four cases. Interestingly, two of those patients had Celiac disease. If macroamylase and macrolipase are present, the possibility of Celiac disease should be considered.
authors.affiliation: Department of Clinical Laboratory, Kobe City General Hospital, Kobe 650-0046.
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Oita
authors.forename: Akiko
authors.initials: A
authors.lastname: Yamashiro
authors.forename: Fumiko
authors.initials: F
authors.lastname: Mizutani
authors.forename: Akiyo
authors.initials: A
authors.lastname: Tamura
authors.forename: Kenji
authors.initials: K
authors.lastname: Sakizono
authors.forename: Akihiko
authors.initials: A
authors.lastname: Okada
mesh_terms: D000368:Aged; D000681:Amylases / Q000097:blood* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D002446:Celiac Disease / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000378:metabolism; D007074:Immunoglobulin G / Q000097:blood / Q000378:metabolism; D008049:Lipase / Q000097:blood* / Q000378:metabolism; D008970:Molecular Weight; D011233:Precipitin Tests; D011485:Protein Binding
chemical_list: D015415:Biomarkers; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D008049:Lipase; D000681:Amylases; C001663:macroamylase