title: Coumarin-4-ylmethoxycarbonyls as phototriggers for alcohols and phenols.
abstract: Caged compounds can be used to regulate the spatial and temporal dynamics of signaling molecules in live cells. Photochemical properties of coumarin-4-ylmethoxy carbonates (1a-d) are investigated to construct caged compounds of hydroxy-containing molecules. All the compounds possess desired properties as phototriggers for alcohols and phenols. The 6-bromo-7-hydroxycoumarin-4-ylmethoxycarbonyl (Bhcmoc) group has the highest photochemical efficiency and is applied to make caged compounds of 1,2-dioctanoylglycerol (diC(8)), Tyr-OMe, and adenosine. [reaction: see text]
authors.affiliation: Department of Biomolecular Science, Toho University, 2-2-1 Miyama, Funabashi, 274-8510 Japan.
authors.forename: Akinobu Z
authors.initials: AZ
authors.lastname: Suzuki
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Watanabe
authors.forename: Mika
authors.initials: M
authors.lastname: Kawamoto
authors.forename: Keiko
authors.initials: K
authors.lastname: Nishiyama
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Yamashita
authors.forename: Megumi
authors.initials: M
authors.lastname: Ishii
authors.forename: Michiko
authors.initials: M
authors.lastname: Iwamura
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Furuta