title: Unchanged striatal dopamine transporter availability in narcolepsy: a PET study with [11C]-CFT.
abstract: OBJECTIVE
  To investigate dopamine reuptake sites (dopamine transporter) in the caudate nucleus and putamen in narcolepsy.
  
  
  METHODS
  Ten patients with narcolepsy and 15 controls were studied with positron emission tomography. A cocaine analogue [11C]-CFT was used as a radioligand.
  
  
  RESULTS
  The uptake of[11C]-CFT was within normal limits (89% of age-adjusted control mean in the caudate nucleus and 91% in the putamen) in patients with narcolepsy.
  
  
  CONCLUSIONS
  No evidence of altered striataldopamine transporter availability was found in narcolepsy.
authors.affiliation: Turku PET-Centre, University of Turku, Turku, Finland. juha.rinne@pet.tyks.fi
authors.forename: J O
authors.initials: JO
authors.lastname: Rinne
authors.forename: C
authors.initials: C
authors.lastname: Hublin
authors.forename: K
authors.initials: K
authors.lastname: Någren
authors.forename: H
authors.initials: H
authors.lastname: Helenius
authors.forename: M
authors.initials: M
authors.lastname: Partinen
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002421:Caudate Nucleus / Q000473:pathology* / Q000502:physiology; D003042:Cocaine / Q000031:analogs & derivatives*; D050483:Dopamine Plasma Membrane Transport Proteins; D018765:Dopamine Uptake Inhibitors; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000502:physiology*; D008875:Middle Aged; D009290:Narcolepsy / Q000503:physiopathology*; D009419:Nerve Tissue Proteins; D011699:Putamen / Q000473:pathology* / Q000502:physiology; D014055:Tomography, Emission-Computed
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D018765:Dopamine Uptake Inhibitors; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C021279:(1R-(exo,exo))-3-(4-fluorophenyl)-8-methyl-8- azabicyclo(3.2.1)octane-2-carboxylic acid, methyl ester; D003042:Cocaine