title: Reversible dilated cardiomyopathy related to amphotericin B therapy.
abstract: We describe a patient who developed dilated cardiomyopathy and clinical congestive heart failure after 2 months of therapy with amphotericin B (AmB) for disseminated coccidioidomycosis. His echocardiographic abnormalities and heart failure resolved after posaconazole was substituted for AmB. It is important to recognize the rare and potentially reversible toxicity of AmB.
authors.affiliation: Department of Infectious Diseases, David Grant USAF Medical Center, Travis AFB, CA 94535, USA. patrick.danaher@60mdg.travis.af.mil
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Danaher
authors.forename: Michael K
authors.initials: MK
authors.lastname: Cao
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Anstead
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Dolan
authors.forename: Caroline C
authors.initials: CC
authors.lastname: DeWitt
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002311:Cardiomyopathy, Dilated / Q000139:chemically induced*; D003047:Coccidioidomycosis / Q000188:drug therapy*; D004338:Drug Combinations; D004452:Echocardiography; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D010715:Phosphatidylglycerols / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D010713:Phosphatidylcholines; D010715:Phosphatidylglycerols; C068538:liposomal amphotericin B; D000666:Amphotericin B