Rad53: a controller ensuring the fine-tuning of histone levels.
Checkpoint proteins are activated in response to genotoxic insults or replication stress to maintain genome integrity. Their function is believed to depend largely on the detection of the DNA damage or defects occurring during replication fork progression.
Quivy
Jean-Pierre
JP
Institut Curie, Research Section, UMR 218 du CNRS, 75218 Paris cedex 05, France.
Almouzni
Geneviève
G
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics*; D064447:Checkpoint Kinase 2; D004249:DNA Damage / Q000235:genetics*; D004261:DNA Replication / Q000235:genetics*; D018816:Genes, cdc / Q000502:physiology; D042822:Genomic Instability / Q000235:genetics; D006657:Histones / Q000378:metabolism*; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins
D018797:Cell Cycle Proteins; D006657:Histones; D029701:Saccharomyces cerevisiae Proteins; D064447:Checkpoint Kinase 2; D017346:Protein Serine-Threonine Kinases; C067022:RAD53 protein, S cerevisiae