title: Increased serum levels of interleukin-6 in malnourished patients with colorectal cancer.
abstract: Peri-operative serum levels of interleukin-6 (IL-6) were determined in 62 patients who underwent resection of colorectal cancer to clarify the relationship between nutritional status and IL-6 response. Patients were divided into two groups based on creatinine height index: malnourished group (n=13) and normally nourished group (n=49). The preoperative median serum level of IL-6 in the malnourished group was significantly higher than in the normally nourished group (P=0.041). The postoperative median serum level of IL-6 in the malnourished group also tended to be higher. In conclusion, the peri-operative IL-6 response may be activated in malnourished colorectal cancer patients.
authors.affiliation: First Department of Surgery, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852 8501, Japan. nakagoe@net.nagasaki-u.ac.jp
authors.forename: Tohru
authors.initials: T
authors.lastname: Nakagoe
authors.forename: Takashi
authors.initials: T
authors.lastname: Tsuji
authors.forename: Terumitsu
authors.initials: T
authors.lastname: Sawai
authors.forename: Kenji
authors.initials: K
authors.lastname: Tanaka
authors.forename: Shigekazu
authors.initials: S
authors.lastname: Hidaka
authors.forename: Shin ichi
authors.initials: Si
authors.lastname: Shibasaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nanashima
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ohbatake
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Toru
authors.initials: T
authors.lastname: Yasutake
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Sugawara
authors.forename: Naoko
authors.initials: N
authors.lastname: Inokuchi
authors.forename: Shimeru
authors.initials: S
authors.lastname: Kamihira
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood* / Q000601:surgery; D003404:Creatinine / Q000652:urine; D004032:Diet; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D044342:Malnutrition / Q000097:blood*; D008875:Middle Aged; D009752:Nutritional Status; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D003404:Creatinine