title: [Superficial grade G2 tumors of the bladder: recurrence, progression, prognosis].
abstract: OBJECTIVE
  The primary objective of this study was to describe the course of a series of grade 2 noninvasive urothelial carcinomas and to determine their prognosis by establishing recurrence, progression and mortality rates The initial histological and endoscopic characteristics were analysed in order to identify risk factors for recurrence and progression towards detrusor invasion.
  
  
  METHODS
  This retrospective study was conducted on 75 patients with initially grade 2 superficial bladder tumours. Tumours were initially multifocal in 47% of cases and were classified as follows: 52 pTa tumours (69%) and 23 pT1 tumours (31%). The mean follow-up was 58 months.
  
  
  RESULTS
  After the initial endoscopic resection, 26 patients (3.9%) received adjuvant therapy by intravesical instillations. The overall recurrence and progression rates in this series were 67% and 7%, respectively. Twelve patients (16%) underwent cystectomy. The specific mortality rate was 2.6%. Among the initial prognostic criteria, only the multifocal nature was identified as a risk factor for recurrence and progression towards detrusor invasion.
  
  
  CONCLUSIONS
  This study confirmed the uncertain prognosis of grade 2 superficial bladder tumours. These tumours have a high recurrence risk with a cystectomy rate of 16%. These tumours require surveillance identical to that of high-grade tumours, at least half-yearly for the first 3 years then annually thereafter.
authors.affiliation: Service d'Urologie, Hôpital Foch, 40, rue Worth, BP 36, 92150 Suresnes.
authors.forename: Philippe
authors.initials: P
authors.lastname: Sebe
authors.forename: Thierry
authors.initials: T
authors.lastname: Lebret
authors.forename: Vincent
authors.initials: V
authors.lastname: Molinie
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Herve
authors.forename: Laurent
authors.initials: L
authors.lastname: Yonneau
authors.forename: Pierre-Marie
authors.initials: PM
authors.lastname: Lugagne
authors.forename: François
authors.initials: F
authors.lastname: Saporta
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Orsoni
authors.forename: Martine
authors.initials: M
authors.lastname: Butreau
authors.forename: Henry
authors.initials: H
authors.lastname: Botto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000473:pathology* / Q000628:therapy*