title: Addressing parents' concerns: do vaccines contain harmful preservatives, adjuvants, additives, or residuals?
abstract: Vaccines often contain preservatives, adjuvants, additives, or manufacturing residuals in addition to pathogen-specific immunogens. Some parents, alerted by stories in the news media or information contained on the World Wide Web, are concerned that some of the substances contained in vaccines might harm their children. We reviewed data on thimerosal, aluminum, gelatin, human serum albumin, formaldehyde, antibiotics, egg proteins, and yeast proteins. Both gelatin and egg proteins are contained in vaccines in quantities sufficient to induce rare instances of severe, immediate-type hypersensitivity reactions. However, quantities of mercury, aluminum, formaldehyde, human serum albumin, antibiotics, and yeast proteins in vaccines have not been found to be harmful in humans or experimental animals.
authors.affiliation: Division of Infectious Diseases, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, and Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104, USA. offit@email.chop.edu
authors.forename: Paul A
authors.initials: PA
authors.lastname: Offit
authors.forename: Rita K
authors.initials: RK
authors.lastname: Jew
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000009:adverse effects / Q000592:standards; D000818:Animals; D001688:Biological Products / Q000009:adverse effects / Q000737:chemistry / Q000592:standards; D004340:Drug Contamination; D004356:Drug Storage; D006801:Humans; D010592:Pharmaceutic Aids / Q000009:adverse effects* / Q000592:standards*; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects / Q000592:standards; D012306:Risk; D014612:Vaccines / Q000009:adverse effects* / Q000737:chemistry / Q000592:standards*
chemical_list: D000277:Adjuvants, Pharmaceutic; D001688:Biological Products; D010592:Pharmaceutic Aids; D011310:Preservatives, Pharmaceutical; D014612:Vaccines