Efficient route to 1,3-Di-N-imidazolylbenzene. A comparison of monodentate vs bidentate carbenes in Pd-catalyzed cross coupling.
A new bis(carbene) ligand architecture has been developed and was evaluated in the Suzuki-Miyaura cross-coupling reaction of various aryl halides with phenylboronic acid. Several new bis(carbene) ligands were tested in different carbene:Pd ratios. Pd(OAc)(2) and Pd(2)(dba)(3) were compared for efficiency as a Pd source. It was found that the Pd(OAc)(2)/bis(carbene) system formed a catalyst for the activation of chlorobenzene. [reaction: see text]
Vargas
Victor C
VC
Department of Chemistry, University of California-Riverside, Riverside, CA 92521-0403, USA.
Rubio
Ramel J
RJ
Hollis
T Keith
TK
Salcido
Martha E
ME