Increased hypocretin-1 levels in cerebrospinal fluid after REM sleep deprivation.
Rat cisternal (CSF) hypocretin-1 in cerebrospinal fluid was measured after 6 or 96 h of REM sleep deprivation and following 24 h of REM sleep rebound. REM deprivation was found to increase CSF hypocretin-1 collected at zeitgeber time (ZT) 8 but not ZT0. Decreased CSF hypocretin levels were also observed at ZT8 after 24 h of REM sleep rebound. These results suggest that REM sleep deprivation activates and REM sleep rebound inhibits the hypocretin system. Increased hypocretin tone during REM deprivation may be important in mediating some of the effects of REM sleep deprivation such as antidepressant effects, hyperphagia and increased sympathetic activity.
Pedrazzoli
Mario
M
Department of Psychobiology/Sleep Institute, Universidade Federal de São Paulo, Rua Napoleao de Barros 925, São Paulo, SP, CEP: 04024-002, Brazil. pedrazzo@psicobio.epm.br
D'Almeida
Vania
V
Martins
Paulo J F
PJ
Machado
Ricardo B
RB
Ling
Lin
L
Nishino
Seiji
S
Tufik
Sergio
S
Mignot
Emmanuel
E
D000818:Animals; D002352:Carrier Proteins / Q000134:cerebrospinal fluid*; D002940:Circadian Rhythm / Q000502:physiology*; D007031:Hypothalamus / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D000068797:Orexins; D051381:Rats; D017208:Rats, Wistar; D012892:Sleep Deprivation / Q000134:cerebrospinal fluid*; D012895:Sleep, REM / Q000502:physiology*; D015854:Up-Regulation / Q000502:physiology; D014851:Wakefulness / Q000502:physiology
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins