[Effects of metoclopramide on intelligence and memory in patients with Tourette syndrome].
OBJECTIVE
To investigate the effects of metoclopramide on the intelligence and memory in patients with Tourette syndrome.


METHODS
Before and after the 3 month treatment of metoclopramide, the intelligence of 25 children with Tourette syndrome was evaluated by the Wechsler intelligence scale fo children, and the memory by the Wechsler memory scale for children.


RESULTS
The scores of intelligence in children treated by metoclopramide increased from 82.27 +/- 13.20 to 90.53 +/- 15.50, with significant difference (P < 0.05). The scores of performance intelligence quotient increased from 84.13 +/- 10.60 to 92.40 +/- 15.30 (P < 0.01). The scores of arithmetic subtle test for the support memory/attention, the block pattern subtle test for the support perception constitution factor, and the vision recognition subtle test for mean short-term memory increased from 8.20 +/- 2.70 to 10.20 +/- 3.21, 9.13 +/- 2.33 to 10.53 +/- 2.94, and 6.07 +/- 4.56 to 8.40 +/- 3.56, respectively.


CONCLUSIONS
Metoclopramide can improve the intelligence, short-term memory and attention in children with Tourette syndrome.
Ye
Hai-cui
HC
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
Xie
Xiao-ling
XL
You
Yong
Y
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007360:Intelligence / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D008787:Metoclopramide / Q000627:therapeutic use*; D005879:Tourette Syndrome / Q000188:drug therapy*; D014888:Wechsler Scales
D008787:Metoclopramide