Total synthesis of (+/-)-acetoxyodontoschismenol using zirconium chemistry.
The dolabellane diterpene (+/-)-acetoxyodontoschismenol has been synthesised for the first time by a short route in which a three component coupling on zirconium is used to assemble all the carbons needed for the skeleton in onepot.
Baldwin
Ian R
IR
Department of Chemistry, University of Southampton, Southampton, UK SO17 1BJ.
Whitby
Richard J
RJ
D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry*; D035926:Hepatophyta / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D015040:Zirconium / Q000737:chemistry*
D004224:Diterpenes; D009942:Organometallic Compounds; C493386:acetoxyodontoschismenol; C023398:Zirconocene dichloride; D015040:Zirconium