Synthesis and studies of 1,2-dihydroquinoline derivatives as inhibitors of lipid peroxidation.
A series of new spiro[naphto[2,1-c][2,7]naphtiridine-5,4'-piperidine] derivatives was prepared. Biochemical investigations revealed that all members of this series were potent inhibitors of both NADPH- and Fe(2+)-dependent lipid peroxidation (IC50 < 10 mumol/l) in rat brain microsomes and rat brain homogenate, respectively.
Barta-Szalai
Gizella
G
Gedeon Richter Ltd., Budapest, Hungary. b.szalai@richter.hu
Gere
Anikó
A
Takács-Novák
Krisztina
K
Domány
György
G
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D007501:Iron / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D009249:NADP / Q000494:pharmacology; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology; D010880:Piperidines / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D009281:Naphthalenes; D010880:Piperidines; D011804:Quinolines; D013141:Spiro Compounds; D009249:NADP; D007501:Iron