title: Haemodynamics and mechanics following partial left ventriculectomy: a computer modeling analysis.
abstract: Mechanics following partial left ventriculectomy is still poorly understood. A computational cylindrical model of the left ventricle was developed, based on the myocardial fibre behaviour for the evaluation of the mechanical and haemodynamical effects of the operation. A healthy left ventricle with physiological geometry and function and a dilated hypokinetic heart were investigated. Haemodynamic and mechanical data were obtained at baseline and compared with those obtained at different degrees of volume reduction. Data included: ejection fraction (EF); stroke volume (SV); end-systolic and end-diastolic pressure-volume relationships (ESPVR and EDPVR), and efficiency. EF increases following volume reduction in both simulation but, concurrently, SV shows modest improvement (dilated ventricle) or reduction (healthy ventricle) at progressive degrees of resection. The ESPVR and EDPVR slope increases and shifts leftward with the resection extent, but the increase of the ESPVR slope is more pronounced in dilated ventricle. Efficiency is improved in the dilated heart after resections, while does not improve when the healthy-heart volume is reduced. The simulation of partial left ventriculectomy suggests an improvement of systolic performance, counterbalanced by increased diastolic stiffness following inverse remodelling. Efficiency of simulated dilated ventricles is enhanced by volume reduction, suggesting a favourable effect of reduction of the metabolic demand of the failing heart.
authors.affiliation: Department of Bioengineering, Politecnico di Milano, Via Golgi 39, 20133 Milan, Italy.
authors.forename: Alberto
authors.initials: A
authors.lastname: Redaelli
authors.forename: Francesco
authors.initials: F
authors.lastname: Maisano
authors.forename: Monica
authors.initials: M
authors.lastname: Soncini
authors.forename: Ottavio
authors.initials: O
authors.lastname: Alfieri
authors.forename: Franco Maria
authors.initials: FM
authors.lastname: Montevecchi
mesh_terms: D000818:Animals; D001794:Blood Pressure; D006348:Cardiac Surgical Procedures / Q000379:methods; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery*; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted; D006339:Heart Rate; D006352:Heart Ventricles / Q000503:physiopathology* / Q000601:surgery*; D018056:Hemorheology / Q000379:methods*; D006801:Humans; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D016896:Treatment Outcome; D020257:Ventricular Remodeling / Q000502:physiology*