title: Does ultrasound contrast agent improve the diagnostic value of colour and power Doppler sonography in superficial lymph node enlargement?
abstract: OBJECTIVE
  to analyse whether ultrasound contrast agent (UCA) improves the diagnostic accuracy to differentiate between benign and malignant superficial lymph node enlargement by using colour-coded duplex sonography (CCDS) and power Doppler (PD).
  
  
  METHODS
  32 patients with suspected malignant superficial lymph node enlargement prospectively underwent standardised ultrasound examinations using B-mode sonography and native and contrast-enhanced CCDS and PD immediately before biopsy. Solbiati-Index (longitudinal-transverse diameter ratio) and intranodal flow patterns by using different vascularisation types were assessed. Histological and sonographical findings were correlated.
  
  
  RESULTS
  27 malignant and 5 benign lymph nodes were found. Solbiati-Index was lower in malignant lymph nodes than in benign nodes (mean 1.5 vs. 2.4, P<0.045). More intranodal flow patterns could be detected after UCA (53 vs. 43) but the number of correctly identified malignant nodes decreased after UCA (26 vs. 24) and the number of correctly identified benign nodes remained constant compared with native CCDS and PD. In 31% of the colour-mode studies, PD was considered to visualise more clearly intranodal vascular flow patterns than CCDS.
  
  
  CONCLUSIONS
  despite depicting more intranodal vascular patterns, the use of an ultrasound contrast agent seems not to improve the diagnostic value of CCDS and PD compared with native colour-mode studies in superficial lymph node enlargement.
authors.affiliation: Department of Radiology, Klinikum Augsburg, Stenglinstr. 2, D-86156 Augsburg, Germany. gernot.sad@gmx.de
authors.forename: Gernot
authors.initials: G
authors.lastname: Schulte-Altedorneburg
authors.forename: Johannes
authors.initials: J
authors.lastname: Demharter
authors.forename: Renate
authors.initials: R
authors.lastname: Linné
authors.forename: Dirk W
authors.initials: DW
authors.lastname: Droste
authors.forename: Klaus
authors.initials: K
authors.lastname: Bohndorf
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Bücklein
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000379:methods; D003287:Contrast Media / Q000008:administration & dosage*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008198:Lymph Nodes / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D008199:Lymphadenitis / Q000000981:diagnostic imaging* / Q000473:pathology; D008207:Lymphatic Metastasis; D008223:Lymphoma / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides / Q000008:administration & dosage; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014388:Tuberculosis, Lymph Node / Q000000981:diagnostic imaging; D018615:Ultrasonography, Doppler, Color / Q000379:methods*
chemical_list: D003287:Contrast Media; D011134:Polysaccharides; C059891:SHU 508