EGFR and wingless signaling pathways interact to specify the ocellar pattern in Drosophila.
This report shows that the Wingless signaling pathway regulates the expression of epidermal growth factor receptor (EGFR) in Drosophila. This pathway specifies cell fate during head development. Blocking wingless signaling upregulates Drosophila epidermal growth factor receptor (DER) activity and expands its expression domains in the eye primordium. Moreover, ectopic expression of wingless inhibits DER signaling and dramatically restricts its expression domain. This study suggests a novel role of wingless in specifying the Drosophila dorsal head via blocking vein expression in this region.
Amin
Amr
A
Biology Department, UAE University, Al-Ain, UAE. a.amin@uaeu.ac.ae
D000818:Animals; D019070:Cell Lineage; D003433:Crosses, Genetic; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism*; D006579:Heterozygote; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008855:Microscopy, Electron, Scanning; D009030:Mosaicism; D017956:Photoreceptor Cells, Invertebrate / Q000196:embryology; D017434:Protein Structure, Tertiary; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D011995:Recombination, Genetic; D015398:Signal Transduction; D015854:Up-Regulation; D051155:Wnt1 Protein
D029721:Drosophila Proteins; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D051155:Wnt1 Protein; C074622:wg protein, Drosophila; D066246:ErbB Receptors