title: Highly conserved protein kinases involved in the regulation of carbon and amino acid metabolism.
abstract: It has been clear for over a decade and a half that ancient signalling pathways controlling fundamental cellular processes are highly conserved throughout the eukaryotes. Two plant protein kinases, sucrose non-fermenting 1 (SNF1)-related protein kinase (SnRK1) and general control non-derepressible 2 (GCN2)-related protein kinase are reviewed here. These protein kinases show an extraordinary level of conservation with their fungal and animal homologues given the span of time since they diverged from them. However, close examination of the signalling pathways in which they operate also reveals intriguing differences in activation and function.
authors.affiliation: Crop Performance and Improvement, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK. nigel.halford@bbsrc.ac.uk
authors.forename: Nigel G
authors.initials: NG
authors.lastname: Halford
authors.forename: Sandra
authors.initials: S
authors.lastname: Hey
authors.forename: Deveraj
authors.initials: D
authors.lastname: Jhurreea
authors.forename: Sophie
authors.initials: S
authors.lastname: Laurie
authors.forename: Rowan S
authors.initials: RS
authors.lastname: McKibbin
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Zhang
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Paul
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000378:metabolism*; D002244:Carbon / Q000378:metabolism*; D017124:Conserved Sequence / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic; D018506:Gene Expression Regulation, Plant; D010944:Plants / Q000201:enzymology* / Q000235:genetics; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D002244:Carbon; D011494:Protein Kinases