Gene expression sigantures, cancer cell evolution and metastatic progression.
Global gene expression profiling and molecular cytogenetics for single cells provide new opportunities to resolve important questions, such as the mechanisms of tumor cell selection during cancer progression. While gene expression analyses show that metastatic progression correlates with the deregulation of certain gene sets in the primary tumor, the direct analysis of disseminated cancer cells, the putative precursors of metachronous metastases, suggests that dissemination is a very early event in the genetic development of human cancers.
Klein
Christoph A
CA
Institut für Immunologie, Ludwig-Maximilians Universität Munchen; Goethestr. 31, 80336 Munchen, Germany. klein@ifi.med.uni-muenchen.de
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D019143:Evolution, Molecular; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics* / Q000502:physiology; D006801:Humans; D007633:Keratins / Q000378:metabolism; D008954:Models, Biological; D009362:Neoplasm Metastasis / Q000235:genetics; D014407:Tumor Cells, Cultured
D007633:Keratins