Bactericidal effect of cethromycin (ABT-773) in an immunocompetent murine pneumococcal pneumonia model.
The efficacy of cethromycin was assessed against isolates of Streptococcus pneumoniae in the presence of neutrophils. Comparison with data from our previous neutropenic model revealed that the presence of neutrophils enhanced the bacteriostatic and bactericidal effect of cethromycin by an average of two- to four-times, respectively.
Capitano
Blair
B
Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, PO Box 5037, Hartford, CT 06102-5037, USA.
Maglio
Dana
D
Banevicius
Mary Anne
MA
Nightingale
Charles H
CH
Nicolau
David P
DP
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D004917:Erythromycin / Q000031:analogs & derivatives / Q000494:pharmacology*; D005260:Female; D007121:Immunocompetence; D048628:Ketolides; D051379:Mice; D008808:Mice, Inbred CBA; D009503:Neutropenia / Q000276:immunology / Q000382:microbiology; D009504:Neutrophils / Q000276:immunology; D011018:Pneumonia, Pneumococcal / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D048628:Ketolides; D004917:Erythromycin; C405499:cethromycin