title: Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide.
abstract: Renieramycins M (1m) and N (1n) were isolated from the Thai sponge Xestospongia sp., pretreated with potassium cyanide in methanolic buffer solution, and their structures and relative stereochemistries were elucidated on the basis of spectroscopic data. This strategy is the first example of the gram-scale preparation of this series of compounds and presents a potential solution for increasing the gram-scale supply of novel natural products from marine sources.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.
authors.forename: Khanit
authors.initials: K
authors.lastname: Suwanborirux
authors.forename: Surattana
authors.initials: S
authors.lastname: Amnuoypol
authors.forename: Anuchit
authors.initials: A
authors.lastname: Plubrukarn
authors.forename: Sunibhond
authors.initials: S
authors.lastname: Pummangura
authors.forename: Akinori
authors.initials: A
authors.lastname: Kubo
authors.forename: Chieko
authors.initials: C
authors.lastname: Tanaka
authors.forename: Naoki
authors.initials: N
authors.lastname: Saito
mesh_terms: D000818:Animals; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D011190:Potassium Cyanide; D044005:Tetrahydroisoquinolines / Q000737:chemistry* / Q000302:isolation & purification*; D013785:Thailand
chemical_list: D044005:Tetrahydroisoquinolines; C482478:renieramycin M; C482479:renieramycin N; D011190:Potassium Cyanide