Role of LH in controlled ovarian stimulation.
Controlled ovarian stimulation has become an integral part of infertility treatment. Specific gonadotropin based protocols become the main strategies for controlled stimulation. To avoid the potentially detrimental effect of premature LH surge on oocytes and/or endometrium development, the GnRH analogs have been incorporated into controlled ovarian stimulation strategies. With the availability of recombinant gonadotropins (i.e. recombinant FSH devoided of LH activity) it is necessary to establish precise role of LH in the folliculogenesis and endometrium development. The benefit of exogenous LH may vary with the GnRH-agonists and antagonists regiment used. The optimal amount of LH or ratio FSH to LH used during therapeutically stimulated growth of follicles is still a problem that needs to be solved in the near future.
Wiesak
Teresa
T
Shore Institute for Reproductive Medicine, Brick, NJ 08724, USA. twiesak@aol.com
D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000037:antagonists & inhibitors; D006801:Humans; D007246:Infertility / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000378:metabolism / Q000627:therapeutic use*; D009865:Oocytes / Q000378:metabolism; D010062:Ovulation Induction / Q000379:methods*; D013256:Steroids / Q000096:biosynthesis
D013256:Steroids; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone