Effects of low-dose angiotensin II receptor blocker candesartan on cardiovascular events in patients with coronary artery disease.
OBJECTIVE
The purpose of this study was to investigate the effects of angiotensin II receptor blockers on the prevention of cardiovascular events in patients with coronary artery disease (CAD).


BACKGROUND
Angiotensin II may contribute to the pathogenesis of CAD. Long-term clinical trials have shown that blockade of the renin-angiotensin system can reduce cardiovascular events in patients with acute myocardial infarction complicated by heart failure.


METHODS
Patients with a history of coronary intervention and no significant coronary stenosis on follow-up angiography 6 months after intervention were randomly assigned into a candesartan group (n = 203; baseline treatment plus candesartan 4 mg/d) or a control group (n = 203; baseline treatment alone). The primary end point was a composite of revascularization, nonfatal myocardial infarction, or cardiovascular death. The secondary end point was hospitalization for cardiovascular causes.


RESULTS
There were no changes in blood pressure and in other coronary risk factors in either group during a mean follow-up of 24 months. Primary end point risk was significantly lower in the candesartan group (n = 12) than in control group patients (n = 25) (P =.03). Candesartan treatment reduced primary end point risk (5.9% vs 12.3% for control subjects; relative risk, 0.47; 95% CI, 0.24 to 0.93). The incidence of all events including secondary end points and noncardiovascular death was significantly lower in the candesartan group than in control group patients (23 vs 40 cases) (P =.02).


CONCLUSIONS
Relatively low-dose candesartan, which did not alter blood pressure levels, reduces cardiovascular risk in high-risk patients with CAD.
Kondo
Junichiro
J
Department of Cardiology, Ogaki Municipal Hospital, Ogaki, Japan.
Sone
Takahito
T
Tsuboi
Hideyuki
H
Mukawa
Hiroaki
H
Morishima
Itsuro
I
Uesugi
Michitaka
M
Kono
Tomohiro
T
Kosaka
Takashi
T
Yoshida
Tomohiro
T
Numaguchi
Yasushi
Y
Matsui
Hideo
H
Murohara
Toyoaki
T
Okumura
Kenji
K
D000368:Aged; D000787:Angina Pectoris / Q000209:etiology / Q000517:prevention & control; D057911:Angiotensin Receptor Antagonists; D001562:Benzimidazoles / Q000627:therapeutic use*; D001713:Biphenyl Compounds; D003327:Coronary Disease / Q000188:drug therapy*; D016757:Death, Sudden, Cardiac; D005260:Female; D006333:Heart Failure / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000401:mortality / Q000517:prevention & control; D009204:Myocardial Revascularization; D011446:Prospective Studies; D013223:Statistics as Topic; D013777:Tetrazoles / Q000627:therapeutic use*
D057911:Angiotensin Receptor Antagonists; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D013777:Tetrazoles; C081643:candesartan