title: Extranodal diffuse follicular center lymphoma mimicking mantle cell lymphoma of the intestine.
abstract: We report a case of diffuse follicular center lymphoma (FCL), which is a morphological variant of follicular lymphoma, resembling multiple lymphomatous polyposis (mantle cell lymphoma of the intestine). The patient was a 48-year-old Japanese man who was found, by colonoscopy, to have numerous small polypoid lesions along the entire large intestine. Abdominal computed tomography revealed hepatosplenomegaly and enlargement of multiple mesenteric lymph nodes. Histologically, the lesion was characterized by diffuse proliferation of small- to medium-sized lymphocytes with cleaved nuclei in the mucosa and submucosa. Immunohistochemical studies showed that the tumor cells were CD20+, CD10+, BCL-2+, CD5-, surface IgM-, and cyclin D1-. Moreover, a cytogenetic study showed a translocation at (14;18)(q32;q21). Finally, this case was diagnosed as diffuse FCL, although the tumor was mimicking mantle cell lymphoma.
authors.affiliation: Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine, Mibu, Shimo-tsuga, Tochigi, Japan.
authors.forename: Shigeki
authors.initials: S
authors.lastname: Tomita
authors.forename: Masaru
authors.initials: M
authors.lastname: Kojima
authors.forename: Johji
authors.initials: J
authors.lastname: Imura
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Hori
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Ueda
authors.forename: Ayako
authors.initials: A
authors.lastname: Koitabashi
authors.forename: Yasunaga
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Nakamura
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Kinuko
authors.initials: K
authors.lastname: Mitani
authors.forename: Akira
authors.initials: A
authors.lastname: Terano
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohkura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kawamata
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujimori
mesh_terms: D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D023881:Colonography, Computed Tomographic; D003113:Colonoscopy; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D007414:Intestinal Neoplasms / Q000175:diagnosis*; D008214:Lymphocytes / Q000473:pathology; D008224:Lymphoma, Follicular / Q000175:diagnosis*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis; D020522:Lymphoma, Mantle-Cell / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic