No evidence for a seriously increased malignancy risk in LGI1-caused epilepsy.
The Leucine-rich Glioma Inactivated-1 (LGI1) gene is supposed to be a tumor suppressor gene involved in glial tumors. Mutations in this gene were recently found to cause autosomal dominant lateral temporal lobe epilepsy (ADLTE). We have now analysed the comorbidity in a large Norwegian ADLTE family. No evidence was found that LGI1 is a high-penetrance tumor suppressor gene associated with a serious risk for malignancies in ADLTE families.
Brodtkorb
Eylert
E
Department of Neurology, St. Olavs's Hospital, Trondheim, Norway.
Nakken
Karl O
KO
Steinlein
Ortrud K
OK
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004833:Epilepsy, Temporal Lobe / Q000235:genetics*; D005190:Family; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009369:Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D018570:Risk Assessment
D047908:Intracellular Signaling Peptides and Proteins; C116499:LGI1 protein, human; D011506:Proteins