title: Isolation, structure elucidation and biological activities of trichofumins A, B, C and D, new 11 and 13mer peptaibols from Trichoderma sp. HKI 0276W.
abstract: Trichofumins A-D were isolated from cultures of Trichoderma sp. HKI 0276 as new 11 and 13mer peptaibols. Similar to 15mer peptaibols they promote morphogenesis of the fungus Phoma destructiva and cause hypothermia in mice as a characteristic of neuroleptic activity. Membrane measurements using a synthetic BLM model showed that A, B, C and D increased membrane permeability for cations in a similar manner as was shown for larger peptaibols but with comparably lower efficiency.
authors.affiliation: Hans-Knöll-Institute for Natural Products Research, Beutenbergstrasse 11a, D-07745 Jena, Germany. aberg@pmail.hki-Jena.de
authors.forename: Albrecht
authors.initials: A
authors.lastname: Berg
authors.forename: Pavel A
authors.initials: PA
authors.lastname: Grigoriev
authors.forename: Thomas
authors.initials: T
authors.lastname: Degenkolb
authors.forename: Torsten
authors.initials: T
authors.lastname: Neuhof
authors.forename: Albert
authors.initials: A
authors.lastname: Härtl
authors.forename: Brigitte
authors.initials: B
authors.lastname: Schlegel
authors.forename: Udo
authors.initials: U
authors.lastname: Gräfe
mesh_terms: D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D004594:Electrophysiology; D005656:Fungal Proteins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D007035:Hypothermia / Q000139:chemically induced; D007476:Ionophores / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008051:Lipid Bilayers; D008297:Male; D051379:Mice; D009024:Morphogenesis / Q000187:drug effects; D014242:Trichoderma / Q000737:chemistry*
chemical_list: D005656:Fungal Proteins; D007476:Ionophores; D008051:Lipid Bilayers