[Protective effect of Polygonum multiflorum thunb on the cerebral cholinergic neurofibers in rats].
OBJECTIVE
To observe the number and morphological changes of cholinergic neurofibers in rats under the destruction of kainic acid, and to investigate the protective effect and the mechanism of polygonum multiflorum thunb (PMT) on acetyl-chorine esterase (AChE) neurofibers.


METHODS
Excitative neurotoxin kainic acid was injected into the basal forebrain, Meynert neucleus, medial septal neucleus and the Broca neucleus to establish the destruction model. Then the destructive experimental group was fed with PMT, and the histochemical method was used to display the changes of AChE fibers, the protection and activation of PMT.


RESULTS
The number of projecting AChE fibers to the cortex and the hippocampus in PMT group was larger than that in the control group, and no morphological destruction was seen in the experimental group (P < 0.01).


CONCLUSIONS
PMT has a protective effect on AchE projecting fibers in rats.
Li
Min
M
Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
Du
Xiao-ping
XP
Ye
Hui
H
D000544:Alzheimer Disease / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D002799:Cholinergic Fibers / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D007608:Kainic Acid; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D028502:Polygonum / Q000737:chemistry; D016548:Prosencephalon / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D007608:Kainic Acid