Cerebral perfusion SPECT imaging for assessment of the effect of hyperbaric oxygen therapy on patients with postbrain injury neural status.
OBJECTIVE
To evaluate the effects of hyperbaric oxygen (HBO) therapy on patients with postbrain injury neural status.


METHODS
Two to 4 courses of HBO therapy and/or medications were used to treat 320 patients who were randomly divided into two groups. Assessment was made with (99m)Tc-ethyl cysteinate dimer ( (99m)Tc-ECD) single photon emission computed tomography (SPECT) before and after treatment.


RESULTS
There was a significant difference between the HBO therapy group and the non-HBO therapy group. HBO therapy was superior to medication treatment alone in the recovery of clinical symptoms, control of epilepsy, and resolution of hydrocephalus (P<0.01).


CONCLUSIONS
HBO therapy has specific curative effects on patients with postbrain injury neural status, and (99m)Tc-ECD SPECT could play an important role in diagnosing postbrain injury neural status and monitoring the therapeutic effects of HBO.
Shi
Xiao-yan
XY
The 2nd Hospital Affiliated to Medical College of Zhejiang University, Hangzhou 310009, China. jzyx@mail.hz.zj.cn
Tang
Zhong-quan
ZQ
Xiong
Bing
B
Bao
Jian-xiu
JX
Sun
Da
D
Zhang
Yun-qiu
YQ
Yao
Yu
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001930:Brain Injuries / Q000000981:diagnostic imaging* / Q000628:therapy*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D016009:Chi-Square Distribution; D002648:Child; D003545:Cysteine / Q000031:analogs & derivatives*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000379:methods*; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011336:Probability; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
D015609:Organotechnetium Compounds; C059659:technetium Tc 99m bicisate; D003545:Cysteine