[Pulmonary embolic ischemia: clinical and experimental aspects].
Pulmonary ischemia is usually related with embolics mechanisms, and this mechanic artery occlusion is not always followed by severe ischemic consequences, because the bronchial circulation changes supply the areas without blood flow. However, small artery vascular remodeling occurs, related to persistent high pulmonary pressure levels, mainly in the chronic pulmonary thromboembolism. Experimental models have been produced to study the relation-ship between mechanic artery occlusion, pulmonary hypertension and vascular remodeling, however, more systematic evaluation is necessary to understand such a these relation-ship, in the ischemic and not ischemic lung parenchyma.
Jatene
Fabio Biscegli
FB
Instituto do Coração do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brasil.
Bernardo
Wanderley Marques
WM
D000818:Animals; D001794:Blood Pressure; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D007511:Ischemia / Q000503:physiopathology*; D023421:Models, Animal; D011652:Pulmonary Circulation / Q000502:physiology; D011655:Pulmonary Embolism / Q000503:physiopathology*; D015427:Reperfusion Injury