Comparative in vitro susceptibilities and bactericidal activities of investigational fluoroquinolone ABT-492 and other antimicrobial agents against human mycoplasmas and ureaplasmas.
We determined in vitro susceptibilities for ABT-492 and other antimicrobials against Mycoplasma pneumoniae, Mycoplasma fermentans, Mycoplasma hominis, and Ureaplasma species. ABT-492 MICs were < or =1 microg/ml, and the agent was bactericidal against selected isolates of M. pneumoniae and M. hominis. ABT-492 has potential for treatment of infections due to these microorganisms.
Waites
Ken B
KB
Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA. waites@path.uab.edu
Crabb
Donna M
DM
Duffy
Lynn B
LB
D000890:Anti-Infective Agents / Q000494:pharmacology*; D024841:Fluoroquinolones; D006801:Humans; D008826:Microbial Sensitivity Tests; D009174:Mycoplasma / Q000187:drug effects*; D016858:Mycoplasma fermentans / Q000187:drug effects; D019535:Mycoplasma hominis / Q000187:drug effects; D009177:Mycoplasma pneumoniae / Q000187:drug effects; D015363:Quinolones / Q000494:pharmacology*; D014509:Ureaplasma / Q000187:drug effects*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C477891:delafloxacin