Usefulness of shear stress pattern in predicting neointima distribution in sirolimus-eluting stents in coronary arteries.
The true 3-dimensional neointimal thickness distribution in sirolimus-eluting stents was investigated in relation to the shear stress distribution, which was obtained from computational fluid dynamics calculations. Small pits were observed between the stent struts in all patients, and a significant inverse relation between neointimal thickness and shear stress was found, indicating that deeper pits were present in the outside curve of the stented segments.
Gijsen
Frank J H
FJ
Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands. f.gijsen@erasmusmc.nl
Oortman
Remko M
RM
Wentzel
Jolanda J
JJ
Schuurbiers
Johan C H
JC
Tanabe
Kengo
K
Degertekin
Muzaffer
M
Ligthart
Jurgen M
JM
Thury
Attila
A
de Feyter
Pim J
PJ
Serruys
Patrick W
PW
Slager
Cornelis J
CJ
D001783:Blood Flow Velocity; D017023:Coronary Angiography; D003326:Coronary Circulation; D003327:Coronary Disease / Q000628:therapy; D003331:Coronary Vessels / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D020123:Sirolimus / Q000008:administration & dosage*; D015607:Stents; D017539:Tunica Intima / Q000473:pathology*
D007166:Immunosuppressive Agents; D020123:Sirolimus