title: A case of uveal, palpebral, and orbital invasions in adult T-Cell leukemia.
abstract: BACKGROUND
  Patients with adult T-cell leukemia (ATL) may have eyelid lymphoma, uveitis, or cytomegalovirus retinitis due to being immunocompromised. However, there have been few reports on the invasion of multiple ocular lesions. We treated 1 unusual ATL patient with uveitis in whom multiple ocular invasions were suspected.
  
  
  METHODS
  A woman in whom ATL was diagnosed 10 years previously complained of blurred vision and decreased visual acuity in the right eye. Anterior uveitis of the right eye was suspected. One week later the cells increased in the anterior chamber, and fibrin exudates and hyphema appeared. She was admitted to our hospital.
  
  
  METHODS
  The visual acuity was 0.04 in the right eye and finger-counting from 30 cm in the left. She was treated with systemic steroid therapy. Inflammation disappeared, but both eyelids became swollen and multiple ocular lesions appeared. She was given carcinostatic therapy once more and the mass lesions decreased. Mass lesions appeared in the iris and in the bulbar conjunctiva. Computed tomography and magnetic resonance imagining (MRI) showed that the mass lesions extended to the right orbit and both nasal cavities. MRI also demonstrated choroidal thickening in the left eye.
  
  
  CONCLUSIONS
  This case documents that ATL cells may cause severe uveitis and invade multiple ocular tissues such as the iris, eyelid, choroids, and orbit.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto, Nagasaki, Japan.
authors.forename: Ayano
authors.initials: A
authors.lastname: Mori
authors.forename: Hiroko Eida
authors.initials: HE
authors.lastname: Deguchi
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Mishima
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitaoka
authors.forename: Tsugio
authors.initials: T
authors.lastname: Amemiya
mesh_terms: D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005143:Eyelids / Q000473:pathology*; D005260:Female; D006801:Humans; D015458:Leukemia, T-Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D009361:Neoplasm Invasiveness; D009915:Orbit / Q000473:pathology*; D011239:Prednisolone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014602:Uvea / Q000473:pathology*; D014792:Visual Acuity
chemical_list: D018931:Antineoplastic Agents, Hormonal; D011239:Prednisolone