title: In vivo imaging and tumor therapy with the sodium iodide symporter.
abstract: There has been great progress in the design of vectors for cancer gene therapy. However, it has been difficult to translate success in the laboratory into clinical practice. A major hurdle in understanding these failures has been the relative difficulty in monitoring repeatedly and non-invasively the biodistribution, gene expression and replication of these viral vector systems. With the advent of molecular imaging technology, this deficiency is being rapidly rectified. A number of reporter genes have been used to monitor gene expression. In this review, we discuss the role of the sodium iodide symporter (NIS) as a reporter and therapeutic gene for cancer gene therapy when combined with various radioactive isotopes.
authors.affiliation: Molecular Medicine Program, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, Minnesota 55905, USA.
authors.forename: David
authors.initials: D
authors.lastname: Dingli
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Russell
authors.forename: John C
authors.initials: JC
authors.lastname: Morris
mesh_terms: D000818:Animals; D003952:Diagnostic Imaging; D017930:Genes, Reporter; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors; D006801:Humans; D009369:Neoplasms / Q000473:pathology* / Q000628:therapy*; D011868:Radioisotopes / Q000378:metabolism; D027981:Symporters / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000099209:Sodium-Iodide Symporters
chemical_list: D011868:Radioisotopes; D027981:Symporters; D000099209:Sodium-Iodide Symporters