title: [Community acquired pneumonia and influenza in children].
abstract: Children without chronic or serious medical conditions are at increased risk for hospitalization during influenza seasons, mainly with respiratory tract infections. But influenza virus infections frequently remain undiagnosed, even in hospitalized patients. We prospectively studied the rate of concomitant and preceding influenza infections in children hospitalized with a community acquired pneumonia (CAP).
  
  
  METHODS
  All 1-15-year-old children with CAP requiring hospitalization between 1st April 2000 and 2002 had nasopharyngeal aspirate for viruses, immunofluorescence and serologies for respiratory pathogens. The peak of influenza IgG measured by complement fixation (CF) is transient, and a titer of 1/64 or more indicates an acute influenza infection in the preceding weeks. Children with chronic disease were excluded and a control group of patients from outpatient clinic was measured.
  
  
  RESULTS
  Among 33 previously healthy children (age 4.9 years, range 1.2-14 years), 8 had a pneumococcal pneumonia, 10 a pneumonia caused by Mycoplasma pneumoniae (MP), 1 by Chlamydia pneumonia, and 8 of unknown origin. In six patients immunofluorescence was positive: Respiratory Syncitial Virus, 2, Adenovirus, 1 and Influenza A, 3 (including a patient with concomitant MP infection). Thirteen of the 33 children (39.4%) had evidence of a recent influenza A infection with CF ab > or = 1/64: with pneumococcal pneumonia, 5/10 with MP pneumonia, 3/8 with unknown origin pneumonia, 9/13 of these previous influenza infections being clinically inapparent. Only 1/30 children of control group (3.3%) had CF ab > or = 1/64.
  
  
  CONCLUSIONS
  In this study, influenza infection is the direct cause of CAP of children in 12% of cases. In other children with CAP, 39.4% of patients had an influenza infection in the preceding weeks which leads to secondary infection caused by Streptococcus pneumoniae or by MP or other pathogens.
authors.affiliation: Service de pédiatrie générale, hôpital Saint-Vincent-de-Paul, AP-HP, 82, avenue Denfert-Rochereau, 75014 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Pons-Catalano
authors.forename: C
authors.initials: C
authors.lastname: Vallet
authors.forename: M
authors.initials: M
authors.lastname: Lorrot
authors.forename: M
authors.initials: M
authors.lastname: Soulier
authors.forename: F
authors.initials: F
authors.lastname: Moulin
authors.forename: E
authors.initials: E
authors.lastname: Marc
authors.forename: M
authors.initials: M
authors.lastname: Chalumeau
authors.forename: J
authors.initials: J
authors.lastname: Raymond
authors.forename: P
authors.initials: P
authors.lastname: Lebon
authors.forename: D
authors.initials: D
authors.lastname: Gendrel
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D009980:Influenza A virus / Q000472:pathogenicity; D009981:Influenza B virus / Q000472:pathogenicity; D007251:Influenza, Human / Q000150:complications*; D008297:Male; D011014:Pneumonia / Q000453:epidemiology* / Q000209:etiology*; D011446:Prospective Studies; D012307:Risk Factors