Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives.
We describe the synthesis and the antiviral evaluation of novel alpha and beta dideoxynucleoside derivatives in which the base has been replaced by a 3-hydroxy-2-methylpyridin-4-one. The syntheses were successfully achieved by the use of the standard Vorbrüggen coupling conditions. Moderate activity of these compounds were found on herpes simplex virus (HSV) type 1 and type 2.
Barral
Karine
K
Laboratoire des Matériaux Moléculaires et des Biomatériaux (UMR-CNRS 6114), Faculté des Sciences de Luminy, case 901, 13288 09, Marseille cedex, France.
Hider
Robert C
RC
Balzarini
Jan
J
Neyts
Johan
J
De Clercq
Erik
E
Camplo
Michel
M
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000077543:Deferiprone; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D008958:Models, Molecular; D011728:Pyridones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D015224:Dideoxynucleosides; D011728:Pyridones; D000077543:Deferiprone