title: Midazolam compared with ketamine for invasive procedures.
abstract: The combination of ketamine and topical placebo cream was compared with the combination of midazolam and topical lidocaine-prilocaine cream (EMLA) in 13 children with leukaemia undergoing bone marrow punctures. This double-blind, randomized, crossover study showed that the children prefer midazolam and EMLA as sedation for invasive procedures and that some parents and the nursing staff have doubts because of the anxiety during the procedure and the physical restraint that often is necessary during midazolam and EMLA. Both methods cause several, more or less unpleasant, side effects.
authors.forename: Rienk Y J
authors.initials: RY
authors.lastname: Tamminga
authors.forename: Wineke
authors.initials: W
authors.lastname: Armbrust
authors.forename: Willem A
authors.initials: WA
authors.lastname: Kamps
mesh_terms: D000293:Adolescent; D019162:Anesthetics, Combined / Q000008:administration & dosage*; D001853:Bone Marrow / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007649:Ketamine / Q000008:administration & dosage*; D008297:Male; D008874:Midazolam / Q000008:administration & dosage*; D011677:Punctures
chemical_list: D019162:Anesthetics, Combined; D007649:Ketamine; D008874:Midazolam