Structure and function of AMPA receptors.
The application of X-ray diffraction has allowed the structure of the ligand-binding core of AMPA receptors to be determined. Here I review the insights that this has given into the molecular mechanisms of activation and desensitization of these receptors.
Gouaux
Eric
E
Department of Biochemistry and Molecular Biophysics and Howard Hughes Medical Institute, Columbia University, 650 West 168th Street, New York, NY 10032, USA. jeg52@columbia.edu
D000818:Animals; D006801:Humans; D015640:Ion Channel Gating / Q000502:physiology; D018091:Receptors, AMPA / Q000737:chemistry* / Q000502:physiology*; D013329:Structure-Activity Relationship
D018091:Receptors, AMPA