title: Evaluation of the blood-aqueous barrier by laser flare cell photometry following retinal cryocoagulation.
abstract: OBJECTIVE
  To evaluate the influence of peripheral 360 degrees retinal cryocoagulation on the blood-aqueous barrier of patients with retinal vascular disorders.
  
  
  METHODS
  The aqueous of 50 eyes of 50 patients with diabetic retinopathy or central vein occlusion was measured by laser flare photometry (FC-2000, Kowa) before peripheral 360 degrees retinal cryocoagulation and 1 day, 1 week, and 1 month thereafter.
  
  
  RESULTS
  Mean aqueous flare values before treatment were 15.7 (+/-8.2) photon counts/ms; mean cell count was 9.8 (+/-14.8) cells/0.5 mm(3). One day after retinal cryocoagulation flare values had increased statistically significantly to a mean of 39.2 (+/-85.8) photon counts/ms, while the increase in mean cell number to 15.0 (+/-37.2) cells/0.5 mm(3) did not reach statistical significance. One week following treatment, mean flare values had dropped to 30.9 (+/-49.6) photon counts/ms and were no longer significantly elevated compared with baseline, while the mean cell count of 11.1 (+/-27.0) cells/0.5 mm(3) was now statistically significantly elevated compared with baseline. One month after treatment the flare values had decreased to a mean of 19.7 (+/-12.0) photon counts/ms, and mean cell count had decreased to 8.1 (+/-10.4) cells/0.5 mm(3); at this point neither parameter showed a statistically significant difference from baseline values.
  
  
  CONCLUSIONS
  Peripheral 360 degrees retinocryocoagulation does not lead to permanent disturbance of the blood-aqueous barrier.
authors.affiliation: Department of Ophthalmology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105 , Bonn, Germany. eter@uni-bonn.de.
authors.forename: Nicole
authors.initials: N
authors.lastname: Eter
authors.affiliation: Department of Ophthalmology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105 , Bonn, Germany.
authors.forename: Manfred
authors.initials: M
authors.lastname: Spitznas
authors.affiliation: Department of Ophthalmology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105 , Bonn, Germany.
authors.forename: Zaher
authors.initials: Z
authors.lastname: Sbeity
authors.affiliation: Department of Ophthalmology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105 , Bonn, Germany.
authors.forename: Antje
authors.initials: A
authors.lastname: Vogel
mesh_terms: D001082:Aqueous Humor / Q000166:cytology*; D018916:Blood-Aqueous Barrier; D002452:Cell Count; D003452:Cryosurgery; D003930:Diabetic Retinopathy / Q000601:surgery*; D006801:Humans; D017075:Laser Coagulation; D007834:Lasers; D010783:Photometry / Q000379:methods*; D012170:Retinal Vein Occlusion / Q000601:surgery*