[Bacterial cyclostatin, or how do bacteria manipulate the eukaryotic cell cycle].
Several bacterial proteins have been recently described that share the ability to inhibit the proliferation of cells in culture without causing early signs of cytotoxicity. Such observations suggest the existence of bacterial mechanisms of control of the eukaryotic cell cycle contributing to pathogenicity or adaptation to the host. This emerging concept of cellular microbiology is critically analyzed considering as a model the cytolethal distending toxins (CDT), a family of toxins whose mode of action on the cell cycle has been thoroughly studied over the last few years. CDTs activate a physiological G2 checkpoint in exposed cells, probably from an initial DNA alteration whose precise molecular nature has not yet been determined. Experimental data are lacking to extrapolate in vivo the antiproliferative effect of these bacterial proteins that we tentatively propose to call cyclostatins.
De Rycke
Jean
J
Laboratoire Inra de Pathologie Infectieuse et Immunologie, BP 1 37380 Nouzilly, France. derycke@tours.inra.fr
Ducommun
Bernard
B
D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D002453:Cell Cycle / Q000502:physiology*; D002455:Cell Division / Q000187:drug effects*; D004249:DNA Damage; D005057:Eukaryotic Cells / Q000502:physiology; D007166:Immunosuppressive Agents / Q000494:pharmacology*
D001427:Bacterial Toxins; D007166:Immunosuppressive Agents; C067044:cytolethal distending toxin