Physicochemical and crystallographic characterization of mefenamic acid complexes with alkanolamines.
The preparation of mefenamic acid (MH)-alkanolamine (propanolamine, diethanolamine, triethanolamine) complexes was attempted to increase the transdermal flux of MH. Differential scanning calorimetry, Fourier transform infrared spectroscopy, and X-ray crystallographic studies demonstrated that MH and each alkanolamine formed an ion pair complex. The series of amine complexes had a lower melting point and higher solubility in water compared with pure MH.
Fang
Liang
L
Faculty of Pharmaceutial Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan.
Numajiri
Sachihiko
S
Kobayashi
Daisuke
D
Ueda
Hideo
H
Nakayama
Koji
K
Miyamae
Hiroshi
H
Morimoto
Yasunori
Y
D000473:Alkanes / Q000032:analysis / Q000737:chemistry*; D000588:Amines / Q000032:analysis / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D018360:Crystallography, X-Ray / Q000379:methods; D046911:Macromolecular Substances; D008528:Mefenamic Acid / Q000032:analysis / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods
D000473:Alkanes; D000588:Amines; D046911:Macromolecular Substances; D008528:Mefenamic Acid