[Effect of stress on calcium homeostasis in muscular tissues].
A dynamics of the content of calcium (Ca) in aorta, heart and skeletal muscles was studied in rats exposed to a stress factor for 21 weeks. We observed a 7-fold increase in its content in all the organs examined by the middle of an experiment and its progressive decrease by the 21-st week. It might result from the stages of stress and development of hypercholisterinemia. An inhibitor of L-type calcium channels niphidipine did not change the dynamics of Ca content qualitatively but it decreased its quantitative parameters, especially at final stages of experiments. We suggest that possible mechanism of keeping calcium homeostasis in the organs examined at different stages of stress is an intensive work of ligand- and potential-dependent calcium channels.
Liashenko
V P
VP
Dnepropetrovsk National University, Ukraine.
Lukashov
S M
SM
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D020746:Calcium Channels, L-Type / Q000378:metabolism; D004195:Disease Models, Animal; D006706:Homeostasis / Q000187:drug effects / Q000502:physiology*; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D009132:Muscles / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism; D009543:Nifedipine / Q000494:pharmacology; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism* / Q000503:physiopathology
D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D009543:Nifedipine; D002118:Calcium