title: Effects of oxygenated carotenoid beta-cryptoxanthin on morphological differentiation and apoptosis in Neuro2a neuroblastoma cells.
abstract: Beta-Cryptoxanthin (beta Cx) was investigated for cell functions in neuroblastoma Neuro2a cells. The following results were obtained. 1. Beta-Cx induced neurite outgrowth. 2. Beta-Cx inhibited the etoposide-induced activation of caspase-3 activity in a dose-dependent manner. These data suggest a bioregulatry function of beta Cx in the control of differentiation and apoptosis in Neuro2a cells.
authors.affiliation: Graduate School of Natural Science and Technology, Okayama University, Japan.
authors.forename: Satoko
authors.initials: S
authors.lastname: Noguchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Sumida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ogawa
authors.forename: Mikiro
authors.initials: M
authors.lastname: Tada
authors.forename: Kyoya
authors.initials: K
authors.lastname: Takahata
mesh_terms: D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects*; D045744:Cell Line, Tumor; D065366:Cryptoxanthins; D006801:Humans; D009447:Neuroblastoma; D014212:Tretinoin / Q000494:pharmacology; D024341:Xanthophylls; D019207:beta Carotene / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D016588:Anticarcinogenic Agents; D065366:Cryptoxanthins; D024341:Xanthophylls; D019207:beta Carotene; D014212:Tretinoin