Association of intercellular adhesion molecule-1 gene with type 1 diabetes.
Intercellular adhesion molecule-1 (ICAM-1) functions via its ligands, the leucocyte integrins, in adhesion of immune cells to endothelial cells and in T cell activation. The third immunoglobulin-like extracellular domain binds integrin Mac-1 and contains a common non-conservative aminoacid polymorphism, G241R. Phenotypically, ICAM-1 has been associated with type 1 diabetes, a T-cell-mediated autoimmune disease. We assessed two independent datasets, and noted that R241 was associated with lower risk of type 1 diabetes than is G241 (3695 families, relative risk 0.91, p=0.03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments.
Nejentsev
Sergey
S
Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke's Hospital, CB2 2XY, Cambridge, UK. sergey.nejentsev@cimr.cam.ac.uk
Guja
Cristian
C
McCormack
Rose
R
Cooper
Jason
J
Howson
Joanna M M
JM
Nutland
Sarah
S
Rance
Helen
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Walker
Neil
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Undlien
Dag
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Ronningen
Kjersti S
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Tuomilehto-Wolf
Eva
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Tuomilehto
Jaakko
J
Ionescu-Tirgoviste
Constantin
C
Gale
Edwin A M
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Bingley
Polly J
PJ
Gillespie
Kathleen M
KM
Savage
David A
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Carson
Dennis J
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Patterson
Chris C
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Maxwell
A Peter
AP
Todd
John A
JA
D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide
D018799:Intercellular Adhesion Molecule-1