title: A new subdural probe for combined intracranial pressure (ICP) and cerebral blood flow (CBF) monitoring.
abstract: We report the development of a new subdural probe for combined intracranial pressure (ICP) and cerebral blood flow (CBF) monitoring with near infrared spectroscopy (NIRS) and indocyanine green (ICG) dye dilution. For NIRS a conventional subdural ICP monitoring probe was supplied with two fiber bundles and 90-degree prisms. Injections of 25 mg ICG were performed. Regional values for the mean transit time of ICG (rmtt(ICG)), cerebral blood flow (rCBF) and cerebral blood volume (rCBV) were calculated. With prototypes of the probe in two patients with intracerebral haemorrhage 18 comparative measurements obtained simultaneously with conventional NIRS (optodes placed on the skin) and the subdural NIRS probe were performed. The new subdural NIRS probe allows combined monitoring of ICP and cerebral hemodynamics in the brain directly, without the influence of extracerebral tissue.
authors.affiliation: Department of Neurosurgery, University of Zurich, Switzerland. Emanuela.Keller@usz.ch
authors.forename: E
authors.initials: E
authors.lastname: Keller
authors.forename: A
authors.initials: A
authors.lastname: Nadler
authors.forename: P
authors.initials: P
authors.lastname: Niederer
authors.forename: Y
authors.initials: Y
authors.lastname: Yonekawa
authors.forename: H-G
authors.initials: HG
authors.lastname: Imhof
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D003422:Critical Care; D004395:Dye Dilution Technique / Q000295:instrumentation*; D004567:Electrodes, Implanted; D004630:Emergencies; D004867:Equipment Design; D006408:Hematoma, Subdural / Q000601:surgery; D006801:Humans; D007208:Indocyanine Green; D020300:Intracranial Hemorrhages / Q000601:surgery*; D007427:Intracranial Pressure / Q000502:physiology*; D008866:Microsurgery; D016343:Monitoring, Intraoperative / Q000295:instrumentation*; D012039:Regional Blood Flow / Q000502:physiology; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation*; D013355:Subdural Space; D013673:Technology Assessment, Biomedical; D014207:Trephining
chemical_list: D007208:Indocyanine Green