Drosophila invasive tumors: a model for understanding metastasis.
Inactivation of Drosophila tumor suppressor genes can cause excessive proliferation and, in some cases, neoplastic growth. Neoplastic growth in Drosophila tissues can also be followed by metastasis upon transplantation into hosts or in vivo. Recently, we have shown that metastatic tumors of Drosophila can provide a model in which to identify genes that are involved in the metastatic process.
Woodhouse
Elisa C
EC
National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. elisa@mail.nih.gov
Liotta
Lance A
LA
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism; D004330:Drosophila / Q000166:cytology / Q000235:genetics* / Q000378:metabolism; D029721:Drosophila Proteins; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D009361:Neoplasm Invasiveness / Q000235:genetics; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D039961:Semaphorins; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
D029721:Drosophila Proteins; D008562:Membrane Glycoproteins; C409766:SEMA3B protein, human; C498727:Sema5c protein, Drosophila; D039961:Semaphorins; D016212:Transforming Growth Factor beta; D025521:Tumor Suppressor Proteins