Pregnancy outcomes in patients after radical trachelectomy.
OBJECTIVE
This study was undertaken to review and analyze the fertility and pregnancy outcomes in patients who have undergone radical trachelectomy as the method of management of invasive carcinoma of the cervix.


METHODS
All preoperative, operative, and follow-up data were collected prospectively. Perinatal information was completed by chart reviews and patient questionnaires.


RESULTS
Of 80 patients having undergone the above procedure, 39 have attempted to conceive for a median of 11 months (range 1-85). There have been a total of 22 pregnancies in 18 patients (4 patients pregnant twice). Of the 22 pregnancies, 18 were viable, with 12 progressing to term and delivering by caesarean section. Preterm premature rupture of membranes was the primary cause of preterm delivery.


CONCLUSIONS
This series confirms that pregnancy is a safe and realistic outcome for women undergoing radical trachelectomy for invasive carcinoma of the cervix. Given the apparently high incidence of preterm premature rupture of membranes, these pregnancies should be managed as high risk.
Bernardini
Marcus
M
Divisions of Gynecologic Oncology and Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Sunnybrook and Women's College Health Science Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.
Barrett
Jon
J
Seaward
Gareth
G
Covens
Allan
A
D000328:Adult; D002277:Carcinoma / Q000473:pathology / Q000601:surgery*; D005260:Female; D005298:Fertility; D005322:Premature Rupture of Fetal Membranes / Q000150:complications; D006801:Humans; D009361:Neoplasm Invasiveness; D007752:Obstetric Labor, Premature / Q000209:etiology; D011184:Postoperative Period; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology / Q000601:surgery*; D011256:Pregnancy Outcome; D011446:Prospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*