Volume expansion enhances plasma endothelin-1.
We hypothesized that acute volume expansion by saline infusion triggers the release of endothelin-1. Bolus intravenous saline infusion (8 mL/min) in six groups of conscious Wistar rats and spontaneously hypertensive rats did not change mean arterial pressure or heart rate (n = 8 to 12). At 1 min after infusion, the plasma endothelin-1 level was significantly increased in Wistar rats and in spontaneously hypertensive rats by 42% and 61%, respectively (unpaired data). In 12 Wistar rats, the endothelin-1 level increased from 0.68 +/- 0.13 to 1.19 +/- 0.17 fmol/mL (mean +/- SEM, P <.0001, paired data). Thus, acute volume load by rapid saline infusion increases plasma endothelin-1 levels. Vasoconstriction induced by endothelin-1 may counteract enhanced circumferential stretch created by volume expansion.
Abdel-Sayed
Saad
S
Division of Hypertension and Vascular Medicine, University Hospital, Lausanne, Switzerland.
Brunner
Hans Rudolf
HR
Nussberger
Juerg
J
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D019332:Endothelin-1 / Q000097:blood / Q000187:drug effects* / Q000502:physiology; D005440:Fluid Therapy / Q000379:methods; D006339:Heart Rate / Q000187:drug effects; D007262:Infusions, Intravenous; D008297:Male; D023421:Models, Animal; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000008:administration & dosage*; D014661:Vasoconstriction / Q000502:physiology
D019332:Endothelin-1; D012965:Sodium Chloride