title: MmTRA1b/phospholipid scramblase 1 gene expression is a new prognostic factor for acute myelogenous leukemia.
abstract: We previously found that expression of the Mm-1 cell-derived transplantability-associated gene 1b (MmTRA1b)/phospholipid scramblase 1 gene was markedly induced during the granulocytic differentiation of human myeloid leukemia cells. To evaluate the role of MmTRA1b expression in human myeloid leukemia, we investigated the relative levels of MmTRA1b transcripts in 81 patients with acute myelogenous leukemia (AML) by the reverse transcriptase polymerase chain reaction. The expression of MmTRA1b in AML-M1, -M5a and -M5b was significantly lower than that in normal bone marrow cells. The levels of MmTRA1b expression in AML-M2 and -M4 varied among patients. Higher MmTRA1b mRNA levels were associated with significantly longer overall survival in AML, especially in AML-M4 patients, independent of chromosomal aberrations such as t(8;21) and inv(16). The present results suggest that the MmTRA1b mRNA level is a new prognostic factor for AML, especially the AML-M4 subtype.
authors.affiliation: Department of Hematology, Showa University School of Medicine, Tokyo, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yokoyama
authors.forename: Takuya
authors.initials: T
authors.lastname: Yamashita
authors.forename: Eisuke
authors.initials: E
authors.lastname: Shiozawa
authors.forename: Atsuko
authors.initials: A
authors.lastname: Nagasawa
authors.forename: Junko
authors.initials: J
authors.lastname: Okabe-Kado
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Nakamaki
authors.forename: Shigeru
authors.initials: S
authors.lastname: Tomoyasu
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kimura
authors.forename: Kazuo
authors.initials: K
authors.lastname: Motoyoshi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Honma
authors.forename: Takashi
authors.initials: T
authors.lastname: Kasukabe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000473:pathology; D002352:Carrier Proteins / Q000032:analysis / Q000235:genetics*; D016022:Case-Control Studies; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000145:classification / Q000175:diagnosis* / Q000201:enzymology; D008297:Male; D008565:Membrane Proteins / Q000032:analysis / Q000235:genetics*; D008875:Middle Aged; D049294:Phospholipid Transfer Proteins; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016019:Survival Analysis
chemical_list: D002352:Carrier Proteins; D008565:Membrane Proteins; D049294:Phospholipid Transfer Proteins; D012333:RNA, Messenger