Genome sequencing and comparative genomics of tropical disease pathogens.
The sequencing of eukaryotic genomes has lagged behind sequencing of organisms in the other domains of life, archae and bacteria, primarily due to their greater size and complexity. With recent advances in high-throughput technologies such as robotics and improved computational resources, the number of eukaryotic genome sequencing projects has increased significantly. Among these are a number of sequencing projects of tropical pathogens of medical and veterinary importance, many of which are responsible for causing widespread morbidity and mortality in peoples of developing countries. Uncovering the complete gene complement of these organisms is proving to be of immense value in the development of novel methods of parasite control, such as antiparasitic drugs and vaccines, as well as the development of new diagnostic tools. Combining pathogen genome sequences with the host and vector genome sequences is promising to be a robust method for the identification of host-pathogen interactions. Finally, comparative sequencing of related species, especially of organisms used as model systems in the study of the disease, is beginning to realize its potential in the identification of genes, and the evolutionary forces that shape the genes, that are involved in evasion of the host immune response.
Carlton
Jane M
JM
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. carlton@tigr.org
D000818:Animals; D000977:Antiparasitic Agents / Q000494:pharmacology / Q000627:therapeutic use; D019295:Computational Biology / Q000379:methods; D019143:Evolution, Molecular; D005828:Genetics, Population; D016678:Genome; D023281:Genomics / Q000379:methods*; D006790:Host-Parasite Interactions; D010271:Parasites / Q000235:genetics* / Q000472:pathogenicity; D010272:Parasitic Diseases / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA; D014612:Vaccines
D000977:Antiparasitic Agents; D014612:Vaccines