title: Initial in situ secondary caries formation: effect of various fluoride-containing restorative materials.
abstract: This study evaluated the effects of various restorative materials (Ariston pHc; Dyract; Vitremer; Tetric Ceram; Compoglass F, F2000; Hytac and Ketac Molar) on initial secondary caries formation in situ. Eighty-eight enamel slabs from sound human molars were sterilized (ethylene dioxide) and embedded in epoxy resin. Standardized tooth preparations were filled with the various restorative materials according to manufacturers' recommendations. One specimen from each group was inserted into one of two buccal aspects of an intraoral appliance worn by 11 volunteers for four weeks, day and night. Oral hygiene was performed without additional fluoride application. During meals and oral hygiene procedures, the appliances were stored in sucrose solution (10%). After in situ exposure, the samples were prepared for microradiographic assessment. Mineral content and lesion depth were evaluated by a dedicated software package (TMR 1.24). Lesion depth and mineral loss of the carious lesions close to Ariston pHc was significantly lower when compared to distant parts of the same lesions (p < 0.05; t-test, Bonferroni-Holm correction). All other materials containing fluoride showed no caries protective effect on surrounding enamel (p > 0.05; t-test, Bonferroni-Holm correction). A hydroxyl-, calcium- and fluoride-containing restorative material hampers demineralization next to the restoration, whereas, fluoride release of various fluoride-containing restorative materials does not affect demineralization of adjacent enamel in situ.
authors.affiliation: Department of Operative Dentistry and Periodontology, University School of Dental Medicine, Freie Universität Berlin, Germany.
authors.forename: A M
authors.initials: AM
authors.lastname: Kielbassa
authors.forename: J
authors.initials: J
authors.lastname: Schulte-Monting
authors.forename: F
authors.initials: F
authors.lastname: Garcia-Godoy
authors.forename: H
authors.initials: H
authors.lastname: Meyer-Lueckel
mesh_terms: D000328:Adult; D002327:Cariostatic Agents / Q000008:administration & dosage*; D020770:Compomers / Q000737:chemistry; D003188:Composite Resins / Q000737:chemistry; D003731:Dental Caries / Q000209:etiology* / Q000473:pathology; D003743:Dental Enamel / Q000187:drug effects; D003764:Dental Materials / Q000737:chemistry*; D003793:Dental Restoration, Permanent; D005260:Female; D005459:Fluorides / Q000008:administration & dosage*; D005899:Glass Ionomer Cements / Q000737:chemistry; D006801:Humans; D008297:Male; D008689:Methacrylates / Q000737:chemistry; D008852:Microradiography; D008875:Middle Aged; D012008:Recurrence; D017001:Tooth Demineralization / Q000209:etiology / Q000473:pathology
chemical_list: C409382:Ariston pHc; D002327:Cariostatic Agents; C105428:Compoglass; D020770:Compomers; D003188:Composite Resins; D003764:Dental Materials; C088486:Dyract; C118368:F2000 cement; D005899:Glass Ionomer Cements; D008689:Methacrylates; C121818:Tetric ceram; C084550:Vitremer; C105429:hytac; C110712:ketac-molar; D005459:Fluorides