title: Perinatal dioxin exposure and later effects--a review.
abstract: Negative effects of perinatal exposure to background levels of dioxins and PCBs in Europe and the USA have been documented. Four facets of development are reviewed in this paper: 1. Brain development and thyroid hormone metabolism. 2. Hepatic effects. 3. Hematopoietic system effects. 4. Lung function. Effects on IQ and behaviour have been documented in children on both sides of the Atlantic Ocean. Non-dioxin-like PCBs, measured in maternal and cord blood and current plasma samples have been implicated. Interference with thyroid hormone metabolism in the mother, in the foetus and in the newborn baby could be responsible for these effects on brain development. During early gestation the foetus is completely dependent on maternal thyroxine (T4). Lower T4 levels in the mother, caused by dioxins and PCBs, might negatively influence (early) brain development. It is plausible that the intrauterine dependency on maternal T4 and the high T4 need shortly after birth makes both these periods vulnerable for environmental influences. Effects of dioxin exposure on thyroid hormone metabolism have been described in the period shortly after birth. These effects are no longer found after two years of age indicating a transient effect. In animal studies, in utero exposure has led to effects on brain development due to abnormal induction of liver enzymes. This induction resulted in lower testosterone and estrogen levels, interfering with brain development in the vulnerable period of language development and the development of visuo-spatial abilities. In humans this developmental period occurs around the thirtieth week of pregnancy. Follow-up studies in puberty and adolescence of the different cohorts studied is necessary to evaluate these negative influences. Damaging effects on the liver found shortly after birth have proven to be transient. Effects on the haematopoietic system are clear immediately after birth, for instance on white blood cells and thrombocytes. An increase in middle ear infections (otitis media) in relation to current levels of PCBs at the age of 4 years was described in the Rotterdam study. Negative effects on lung function in the sense of increased obstruction was found after 8 years in relation to perinatal exposure to dioxins in the Zaandam study. This rather new finding might explain the sharp increase in lung problems in children in the Western world.
authors.affiliation: Department of Paediatrics and Neonatology, Emma Children's Hospital Academic Medical Centre, University of Amsterdam, Hollandstraat 6, 3634 AT Loenersloot, The Netherlands.
authors.forename: Gavin W
authors.initials: GW
authors.lastname: ten Tusscher
authors.forename: Janna G
authors.initials: JG
authors.lastname: Koppe
mesh_terms: D001923:Brain Chemistry / Q000187:drug effects*; D004147:Dioxins / Q000032:analysis / Q000633:toxicity*; D004781:Environmental Exposure; D005060:Europe; D006413:Hematopoietic System / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D014481:United States
chemical_list: D004147:Dioxins