Effects of oxygenated carotenoid beta-cryptoxanthin on morphological differentiation and apoptosis in Neuro2a neuroblastoma cells.
Beta-Cryptoxanthin (beta Cx) was investigated for cell functions in neuroblastoma Neuro2a cells. The following results were obtained. 1. Beta-Cx induced neurite outgrowth. 2. Beta-Cx inhibited the etoposide-induced activation of caspase-3 activity in a dose-dependent manner. These data suggest a bioregulatry function of beta Cx in the control of differentiation and apoptosis in Neuro2a cells.
Noguchi
Satoko
S
Graduate School of Natural Science and Technology, Okayama University, Japan.
Sumida
Takashi
T
Ogawa
Hiroshi
H
Tada
Mikiro
M
Takahata
Kyoya
K
D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002454:Cell Differentiation / Q000187:drug effects*; D045744:Cell Line, Tumor; D065366:Cryptoxanthins; D006801:Humans; D009447:Neuroblastoma; D014212:Tretinoin / Q000494:pharmacology; D024341:Xanthophylls; D019207:beta Carotene / Q000031:analogs & derivatives* / Q000494:pharmacology*
D016588:Anticarcinogenic Agents; D065366:Cryptoxanthins; D024341:Xanthophylls; D019207:beta Carotene; D014212:Tretinoin