Cutaneous lymphoplasmacytoid lymphoma (immunocytoma) with Waldenström's macroglobulinemia mimicking rosacea.
A 50-year-old woman presented with a 2-year history of facial lesions that were resistant to rosacea therapy. Evaluation of histology, immunohistochemistry, gene rearrangement study, bone-marrow biopsy specimen, and systemic workup revealed the findings of lymphoplasmacytoid lymphoma (immunocytoma) in both the skin lesions and bone marrow, and IgM kappa paraprotein. Lesions cleared after chemotherapy.
Colvin
Jill H
JH
Department of Dermatology, University of Cincinnati College of Medicine, Cincinnati, OH 45267-0592, USA.
Lamerson
Cindy L
CL
Cualing
Hernani
H
Mutasim
Diya F
DF
D001854:Bone Marrow Cells; D003937:Diagnosis, Differential; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007150:Immunohistochemistry; D015451:Leukemia, Lymphocytic, Chronic, B-Cell; D016393:Lymphoma, B-Cell / Q000473:pathology*; D008875:Middle Aged; D010266:Paraproteins / Q000032:analysis; D012393:Rosacea / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*; D008258:Waldenstrom Macroglobulinemia / Q000473:pathology*
D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D010266:Paraproteins