Immunotherapy and gene therapy of cancer using antibodies or their genes against tumor-associated antigens.
The purpose of this article is to review the current significance of anti-tumor-associated antigen (TAA) antibodies in the therapy of cancer. Current data suggest that antibodies or their genes against TAAs can be used in order to increase the tumor specificity of various therapeutic approaches against cancer, thereby enhancing the tumoricidal effect of each treatment while reducing the side-effects.
Kuroki
Masahide
M
Department of Biochemistry, Fukuoka University School of Medicine, Fukuoka University Molecular Oncology Center, Fukuoka, Japan. kurokima@fukuoka-u.ac.jp
Shibaguchi
Hirotomo
H
Imakiire
Takayuki
T
Uno
Koichi
K
Shirota
Kyoko
K
Higuchi
Takao
T
Shitama
Tomomi
T
Yamada
Hiromi
H
Hirose
Yumiko
Y
Nagata
Akihisa
A
Kuroki
Motomu
M
D000818:Animals; D000912:Antibodies, Neoplasm / Q000235:genetics* / Q000276:immunology / Q000627:therapeutic use*; D000951:Antigens, Neoplasm / Q000276:immunology*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm