Abnormal sensorimotor integration is related to disease severity in Parkinson's disease: a TMS study.
Hyperexcitability of the motor system has been reported in Parkinson's disease (PD). We evaluate how cutaneous afferents modulate motor excitability in PD patients and whether abnormal modulation is correlated to parkinsonian symptoms. Digital stimulation causes abnormal enhancement of motor responses in patients. This effect may be one of the features of motor hyperexcitability in PD. Cutaneomotor hyperexcitability correlates with clinical scores, suggesting that abnormal processing of cutaneous inputs might contribute to the pathogenesis of parkinsonian symptoms.
Tamburin
Stefano
S
Department of Neurological Sciences and Vision, Section of Neurological Rehabilitation, University of Verona, Verona, Italy. stefano.tamburin@mail.univr.it
Fiaschi
Antonio
A
Idone
Domenico
D
Lochner
Piergiorgio
P
Manganotti
Paolo
P
Zanette
Giampietro
G
D000368:Aged; D000369:Aged, 80 and over; D019054:Evoked Potentials, Motor / Q000502:physiology; D005246:Feedback; D005260:Female; D020233:Gait Disorders, Neurologic / Q000175:diagnosis*; D006801:Humans; D008280:Magnetics / Q000295:instrumentation; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000175:diagnosis; D012720:Severity of Illness Index; D012886:Skull