[Study of antiarrhythmic activity and duration of action of quaternidine].
The results of experiments on dogs showed that quaternidine, a quaternary ammonium derivative of trimecaine, produces a significant antiarrhythmogenic effect in cases of rhythm disorders in the late stage of a model myocardial infarction. For drugs administered in a single isotoxic dose, the therapeutic effect of quaternidine in animals with acute myocardial ischemia considerably exceeds the duration of action of lidocaine and trimecaine.
Moiseeva
I Ia
IIa
Department of Pharmacology, Mordvinian State University, ul. Bol'shevistskaya 68, Saransk, Mordvinia, 430000 Russia.
Blinov
D S
DS
Kostin
Ia V
IaV
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D000644:Quaternary Ammonium Compounds / Q000627:therapeutic use*; D011802:Quinidine / Q000627:therapeutic use; D014288:Trimecaine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D018879:Ventricular Premature Complexes / Q000188:drug therapy* / Q000503:physiopathology
D000889:Anti-Arrhythmia Agents; D000644:Quaternary Ammonium Compounds; C482579:quaternidine; D014288:Trimecaine; D011802:Quinidine