title: Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives.
abstract: We describe the synthesis and the antiviral evaluation of novel alpha and beta dideoxynucleoside derivatives in which the base has been replaced by a 3-hydroxy-2-methylpyridin-4-one. The syntheses were successfully achieved by the use of the standard Vorbrüggen coupling conditions. Moderate activity of these compounds were found on herpes simplex virus (HSV) type 1 and type 2.
authors.affiliation: Laboratoire des Matériaux Moléculaires et des Biomatériaux (UMR-CNRS 6114), Faculté des Sciences de Luminy, case 901, 13288 09, Marseille cedex, France.
authors.forename: Karine
authors.initials: K
authors.lastname: Barral
authors.forename: Robert C
authors.initials: RC
authors.lastname: Hider
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.forename: Johan
authors.initials: J
authors.lastname: Neyts
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Michel
authors.initials: M
authors.lastname: Camplo
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000077543:Deferiprone; D015224:Dideoxynucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D008958:Models, Molecular; D011728:Pyridones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D015224:Dideoxynucleosides; D011728:Pyridones; D000077543:Deferiprone