Low incidence and prevalence of hepatitis C virus infection among sexually active non-intravenous drug-using adults, San Francisco, 1997-2000.
BACKGROUND
The rate of sexual transmission of hepatitis C virus (HCV) is debated.


OBJECTIVE
The goal was to measure the risk of sexual transmission of hepatitis C virus (HCV) in a sexually active population.


METHODS
Sexual behaviors and HCV antibody status were measured in persons seeking repeat HIV testing in San Francisco from October 1997 through March 2000.


RESULTS
Among 981 repeat testers, the prevalence of HCV antibody was 2.5%. Among men who have sex with men who denied intravenous drug use (n=746), factors associated with HCV antibody positivity include age greater than 50 years (odds ratio [OR], 8.5; 95% confidence interval [CI], 2.6-27.7), HIV infection (OR, 5.7; 95% CI, 1.6-20.6), and being nonwhite (OR, 3.3; 95% CI, 1.1-10.0). HCV antibody positivity was not associated with sexual risk behaviors. In 576.6 person-years of observation, no new HCV seroconversions occurred (incidence=0 per 100 person-year; 95% CI, 0-.6), whereas 6 new herpes simplex virus-2 infections (2.8 per 100 person-years) and 10 new HIV infections (1.8 per 100 person-years) occurred.


CONCLUSIONS
The absence of new HCV infections in this sample supports the hypothesis that the risk of sexual transmission of HCV is low.
Hammer
Gwendolyn P
GP
San Francisco Department of Public Health, San Francisco, California. ghammer@epi-center.ucsf.edu
Kellogg
Timothy A
TA
McFarland
Willi C
WC
Wong
Ernest
E
Louie
Brian
B
Williams
Ian
I
Dilley
James
J
Page-Shafer
Kimberly
K
Klausner
Jeffrey D
JD
D000293:Adolescent; D000328:Adult; D035041:Anonymous Testing; D005260:Female; D016174:Hepacivirus / Q000276:immunology / Q000302:isolation & purification; D006508:Hepatitis Antibodies / Q000032:analysis / Q000097:blood; D006526:Hepatitis C / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012495:San Francisco / Q000453:epidemiology; D012725:Sexual Behavior; D012749:Sexually Transmitted Diseases / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control*; D015819:Substance Abuse, Intravenous
D006508:Hepatitis Antibodies