title: Recent progress in high-performance capillary bioseparations.
abstract: Bioanalysis is a fast growing domain with new technological developments in the field of mass spectrometry, separation science, and bioinformatics. The central role of separation prior to detection and evaluation of analytes is indisputable. In fact, since the decipherment of the human genome via multichannel capillary electrophoresis in combination with laser-induced fluorescence [1], the analysis of the proteome, i.e., the type and amount of all proteins expressed at a certain time by the genome in a cell or tissue [2] became of central interest. Therefore, new fast and sensitive capillary liquid chromatographic, electrophoretic, and electrochromatographic separation techniques, suitable for high-throughput analysis of proteins, peptides and nucleic acids, are required.
authors.affiliation: Institute of Analytical Chemistry and Radiochemistry, Leopold-Franzens University, Innsbruck, Austria. christian.w.huck@uibk.ac.at
authors.forename: Christian W
authors.initials: CW
authors.lastname: Huck
authors.forename: Günther
authors.initials: G
authors.lastname: Stecher
authors.forename: Rania
authors.initials: R
authors.lastname: Bakry
authors.forename: Günther K
authors.initials: GK
authors.lastname: Bonn
mesh_terms: D001483:Base Sequence; D002853:Chromatography, Liquid / Q000379:methods; D019295:Computational Biology; D019075:Electrophoresis, Capillary / Q000379:methods; D009696:Nucleic Acids / Q000032:analysis*; D020411:Oligonucleotide Array Sequence Analysis; D011506:Proteins / Q000032:analysis*
chemical_list: D009696:Nucleic Acids; D011506:Proteins