Efficacy of sulforaphane in eradicating Helicobacter pylori in human gastric xenografts implanted in nude mice.
Sulforaphane, an isothiocyanate abundant in the form of its glucosinolate precursor in broccoli sprouts, has shown in vitro activity against Helicobacter pylori. We evaluated the effect of sulforaphane in vivo against this bacterium by using human gastric xenografts in nude mice. H. pylori was completely eradicated in 8 of the 11 sulforaphane-treated grafts. This result suggests that sulforaphane might be beneficial in the treatment of H. pylori-infected individuals.
Haristoy
Xavier
X
Laboratoire de Bactériologie-Virologie, UMR CNRS 75-65, Faculté de Médecine, Université Henri-Poincaré, Vandaeuvre-les-Nancy, France.
Angioi-Duprez
Karine
K
Duprez
Adrien
A
Lozniewski
Alain
A
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001937:Brassica / Q000737:chemistry*; D015169:Colony Count, Microbial; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D017879:Isothiocyanates; D051379:Mice; D008819:Mice, Nude; D010936:Plant Extracts / Q000494:pharmacology; D013270:Stomach / Q000382:microbiology* / Q000637:transplantation*; D013454:Sulfoxides; D013861:Thiocyanates / Q000627:therapeutic use*; D014183:Transplantation, Heterologous
D000890:Anti-Infective Agents; D017879:Isothiocyanates; D010936:Plant Extracts; D013454:Sulfoxides; D013861:Thiocyanates; C016766:sulforaphane