Reactivation of Epstein-Barr virus in patients with systemic lupus erythematosus.
A link between Epstein-Barr Virus (EBV) and systemic lupus erythematosus (SLE) has been suggested. However, recent advances in molecular technology now permit more detailed analysis. Sera from SLE patients were tested for antibodies to several EBV antigens and had a significantly higher prevalence of immunoglobulin G antibodies against EBV early antigens than in normal or disease controls. This suggests that recent EBV infection or virus reactivation was occurring in these patients.
Huggins
Mary L
ML
Division of Immunology, School of Molecular Medical Sciences, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK. mary.huggins@nottingham.ac.uk
Todd
Ian
I
Powell
Richard J
RJ
D000328:Adult; D017677:Age Distribution; D000368:Aged; D016022:Case-Control Studies; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology*; D019309:Epstein-Barr Virus Nuclear Antigens / Q000032:analysis / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D004854:Herpesvirus 4, Human / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000276:immunology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011336:Probability; D012016:Reference Values; D018570:Risk Assessment; D017678:Sex Distribution; D018709:Statistics, Nonparametric
D019309:Epstein-Barr Virus Nuclear Antigens