Human ileal bile acid-binding protein promoter and the effects of CDX2.
The ileal bile acid-binding protein (IBABP) is important for the reabsorption of bile salts in the distal small intestine. Studies with the human IBABP gene (FABP6, on chromosome 5q33.3-q34) defined the major transcription start site and identified conserved elements. A consensus element for the caudal-related homeobox factor CDX2 was functional in gel-shift assays and in transfection experiments.
Barley
Natalie F
NF
Gastroenterology Section, Faculty of Medicine, Imperial College London, UK.
Taylor
Vivienne
V
Shaw-Smith
Charles J
CJ
Chakravarty
Probir
P
Howard
Alison
A
Legon
Stephen
S
Walters
Julian R F
JR
D001483:Base Sequence; D000071616:CDX2 Transcription Factor; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D006913:Hydroxysteroid Dehydrogenases; D007082:Ileum / Q000378:metabolism*; D008562:Membrane Glycoproteins; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D015534:Trans-Activators; D045002:3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
D000071616:CDX2 Transcription Factor; D002352:Carrier Proteins; D018398:Homeodomain Proteins; D006913:Hydroxysteroid Dehydrogenases; D008562:Membrane Glycoproteins; D015534:Trans-Activators; C037643:bile acid binding proteins; C435496:AKR1C2 protein, human; D045002:3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)