title: Effect of explosive resistance training on titin and myosin heavy chain isoforms in trained subjects.
abstract: The purpose of this investigation was to evaluate changes in myosin heavy chain (MyHC) and titin isoforms after using various loads during explosive jump squat training. Twenty-four male athletic subjects were recruited for this study. Two experimental groups performed 8-weeks of jump squats using either 30% (n = 9) or 80% (n = 9) of their previously determined 1 repetition maximum. A third group served as controls (n = 6). Muscle biopsies were obtained before and after 8 weeks from vastus lateralis. The analysis of titin within these subjects confirmed that human skeletal muscle contains 2 isoforms of titin. There was no significant group x time interaction for MyHC or titin isoform expression. The data from this investigation indicates that a relatively short period of explosive resistance training results in negligible changes in the expression of MyHC or titin isoforms.
authors.affiliation: Musculoskeletal Research Center, Department of Exercise and Sport Science, University of Wisconsin- La Crosse, La Crosse, Wisconsin 54601, USA. mcguigan.mich@uwlax.edu
authors.forename: Michael R
authors.initials: MR
authors.lastname: McGuigan
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Sharman
authors.forename: Robert U
authors.initials: RU
authors.lastname: Newton
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Davie
authors.forename: Aron J
authors.initials: AJ
authors.lastname: Murphy
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: McBride
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015153:Blotting, Western; D064211:Connectin; D004591:Electrophoresis, Polyacrylamide Gel; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D009124:Muscle Proteins / Q000378:metabolism*; D018995:Myosin Heavy Chains / Q000378:metabolism*; D020033:Protein Isoforms; D011494:Protein Kinases / Q000378:metabolism*; D014891:Weight Lifting / Q000502:physiology*
chemical_list: D064211:Connectin; D009124:Muscle Proteins; D020033:Protein Isoforms; C577285:TTN protein, human; D011494:Protein Kinases; D018995:Myosin Heavy Chains