title: Cerebral perfusion SPECT imaging for assessment of the effect of hyperbaric oxygen therapy on patients with postbrain injury neural status.
abstract: OBJECTIVE
  To evaluate the effects of hyperbaric oxygen (HBO) therapy on patients with postbrain injury neural status.
  
  
  METHODS
  Two to 4 courses of HBO therapy and/or medications were used to treat 320 patients who were randomly divided into two groups. Assessment was made with (99m)Tc-ethyl cysteinate dimer ( (99m)Tc-ECD) single photon emission computed tomography (SPECT) before and after treatment.
  
  
  RESULTS
  There was a significant difference between the HBO therapy group and the non-HBO therapy group. HBO therapy was superior to medication treatment alone in the recovery of clinical symptoms, control of epilepsy, and resolution of hydrocephalus (P<0.01).
  
  
  CONCLUSIONS
  HBO therapy has specific curative effects on patients with postbrain injury neural status, and (99m)Tc-ECD SPECT could play an important role in diagnosing postbrain injury neural status and monitoring the therapeutic effects of HBO.
authors.affiliation: The 2nd Hospital Affiliated to Medical College of Zhejiang University, Hangzhou 310009, China. jzyx@mail.hz.zj.cn
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Shi
authors.forename: Zhong-quan
authors.initials: ZQ
authors.lastname: Tang
authors.forename: Bing
authors.initials: B
authors.lastname: Xiong
authors.forename: Jian-xiu
authors.initials: JX
authors.lastname: Bao
authors.forename: Da
authors.initials: D
authors.lastname: Sun
authors.forename: Yun-qiu
authors.initials: YQ
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Yao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001930:Brain Injuries / Q000000981:diagnostic imaging* / Q000628:therapy*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D016009:Chi-Square Distribution; D002648:Child; D003545:Cysteine / Q000031:analogs & derivatives*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006931:Hyperbaric Oxygenation / Q000379:methods*; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011336:Probability; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
chemical_list: D015609:Organotechnetium Compounds; C059659:technetium Tc 99m bicisate; D003545:Cysteine