Gabapentin-induced hypoglycemia in a long-term peritoneal dialysis patient.
An end-stage renal disease patient on long-term peritoneal dialysis was admitted with dizziness, fatigue, hypoglycemia, and hypotension. The hypotension resolved with intravenous normal saline, but the hypoglycemia persisted for 3 days despite an intravenous dextrose drip and discontinuation of gabapentin. The patient became normoglycemic on the fourth day of admission. None of the known causes for the hypoglycemia were identified except gabapentin, the dose of which was recently doubled 1 month before admission. Insulin and C-peptide levels were high during the hypoglycemic episode and returned to normal after discontinuation of gabapentin. The patient remains off gabapentin and has had no further episodes of hypoglycemia. To our knowledge, this is the first case of hypoglycemia induced by gabapentin.
Penumalee
Sreelatha
S
Department of Medicine, Division of Nephrology, Wayne State University School of Medicine, Detroit, MI 48201, USA. spenumalee@med.wayne.edu
Kissner
Paul Z
PZ
Migdal
Stephen D
SD
D000085:Acetates / Q000009:adverse effects* / Q000494:pharmacology; D000588:Amines; D002096:C-Peptide / Q000097:blood; D003509:Cyclohexanecarboxylic Acids; D005260:Female; D000077206:Gabapentin; D005943:Gluconeogenesis; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced* / Q000209:etiology / Q000378:metabolism; D007022:Hypotension / Q000139:chemically induced; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007672:Kidney Cortex / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D008099:Liver / Q000378:metabolism; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects; D016105:Parathyroidectomy; D010530:Peritoneal Dialysis; D011183:Postoperative Complications / Q000139:chemically induced; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D002096:C-Peptide; D003509:Cyclohexanecarboxylic Acids; D007328:Insulin; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin