Aerobic ruthenium-catalyzed oxidative cyanation of tertiary amines with sodium cyanide.
RuCl3-catalyzed oxidative cyanation of tertiary amines with sodium cyanide under molecular oxygen (1 atm) at 60 degrees C gives the corresponding alpha-aminonitriles, which are versatile synthetic intermediates of various compounds such as amino acids and unsymmetrical 1,2-diamines, in excellent yields. This reaction is clean and should be an environmentally benign and useful process.
Murahashi
Shun-Ichi
S
Department of Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan. murahashi@high.ous.ac.jp
Komiya
Naruyoshi
N
Terai
Hiroyuki
H
Nakae
Takahiro
T
D000588:Amines / Q000737:chemistry*; D000596:Amino Acids / Q000138:chemical synthesis*; D002384:Catalysis; D010084:Oxidation-Reduction; D012428:Ruthenium / Q000737:chemistry*; D012966:Sodium Cyanide / Q000737:chemistry*
D000588:Amines; D000596:Amino Acids; D012428:Ruthenium; D012966:Sodium Cyanide