Multi-species sequence comparison: the next frontier in genome annotation.
Multi-species comparisons of DNA sequences are more powerful for discovering functional sequences than pairwise DNA sequence comparisons. Most current computational tools have been designed for pairwise comparisons, and efficient extension of these tools to multiple species will require knowledge of the ideal evolutionary distance to choose and the development of new algorithms for alignment, analysis of conservation, and visualization of results.
Dubchak
Inna
I
Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. ildubchak@lbl.gov
Frazer
Kelly
K
D000818:Animals; D017124:Conserved Sequence / Q000235:genetics; D019143:Evolution, Molecular; D016678:Genome; D006801:Humans; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics; D016415:Sequence Alignment / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods