title: Bone diseases in children receiving growth hormone.
abstract: The authors report two cases of bone disorders in children with short stature, with confirmed growth hormone (GH) deficiency treated by GH supplementation. The first patient, aged 15 years, developed avascular necrosis of the femoral head and scoliosis. The second one, aged 17 years, had avascular necrosis of the femoral capital epiphysis on one side and acute slipped capital femoral epiphysis (SCFE) on the other side. All these complications were diagnosed while they were receiving GH-therapy. The exact aetiology and the role of GH in the pathogenesis of these conditions are still unknown.
authors.affiliation: Department of Paediatric Orthopaedics, Tunis Children's Hospital (Hôpital d'Enfants de Tunis), Bab Saadoun 1007 Tunis, Tunisia. mahmoud.smida@rns.tn
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Smida
authors.forename: Hbib
authors.initials: H
authors.lastname: Nouri
authors.forename: Hajer
authors.initials: H
authors.lastname: Kandara
authors.forename: Chakib
authors.initials: C
authors.lastname: Jalel
authors.forename: Maher
authors.initials: M
authors.lastname: Ben Ghachem
mesh_terms: D000293:Adolescent; D004839:Epiphyses, Slipped / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005271:Femur Head Necrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000175:diagnosis / Q000188:drug therapy; D019382:Human Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011859:Radiography; D018570:Risk Assessment; D012600:Scoliosis / Q000139:chemically induced* / Q000000981:diagnostic imaging; D012720:Severity of Illness Index
chemical_list: D019382:Human Growth Hormone