title: The role of chromosomal translocation (15;19) in the carcinoma of the upper aerodigestive tract in children.
abstract: OBJECTIVE
  To further evaluate the role of chromosomal translocation (15;19) in the presentation of the carcinoma (CA) of the upper aerodigestive tract.
  
  
  METHODS
  A retrospective study at a tertiary care pediatric medical center.
  
  
  RESULTS
  Seven patients with a mean age of 12 years presented with CA of nasopharynx (N = 2), sinonasal region (N = I), parotid gland (N = 2), or larynx (N = 2). Treatments included combinations of surgery (N = 5), chemotherapy (N = 5), and radiation therapy (N = 4). One patient with sinonasal CA and one patient with laryngeal CA had chromosomal translocation (15;19); these patients both died of their disease with a mean survival of 6 months. The 5 patients without translocation (15;19) responded well to treatment and are disease-free with a mean follow-up of 47 months.
  
  
  CONCLUSIONS
  The preliminary results appear to indicate poor prognosis associated with the presentation of chromosomal translocation (15;19) despite aggressive multi-modality treatment. Further investigation is needed to better understand the cause and relationship of the translocation (15;19) and aggressive behavior of these tumors.
authors.affiliation: Department of Otolaryngology, Children's Hospital, Boston, MA 02115, USA. reza.rahbar@childrens.edu
authors.forename: Reza
authors.initials: R
authors.lastname: Rahbar
authors.forename: Sara O
authors.initials: SO
authors.lastname: Vargas
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Miyamoto
authors.forename: Antonio R
authors.initials: AR
authors.lastname: Perez-Atayde
authors.forename: Christopher A
authors.initials: CA
authors.lastname: French
authors.forename: Caroline D
authors.initials: CD
authors.lastname: Robson
authors.forename: Greg R
authors.initials: GR
authors.lastname: Licameli
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Fletcher
authors.forename: Karen C
authors.initials: KC
authors.lastname: Marcus
authors.forename: Holcombe E
authors.initials: HE
authors.lastname: Grier
authors.forename: Trevor J
authors.initials: TJ
authors.lastname: McGill
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Healy
mesh_terms: D000293:Adolescent; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D002901:Chromosomes, Human, 13-15; D002903:Chromosomes, Human, 19-20; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D010307:Parotid Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D014178:Translocation, Genetic / Q000235:genetics*