New indole alkaloids from the North Sea bacterium Vibrio parahaemolyticus Bio249.
Several bis- and tris-indole derivatives were isolated from a North Sea bacterium that was closely related to Vibrio parahaemolyticus (98% homology). 1,1,3-Tris(3-indolyl)butane (3) is a new compound, and 3,3-bis(3-indolyl)butane-2-one (1a), arundine (1b), and 1,1,1-tris(3-indolyl)methane (2a) were isolated from a microorganism for the first time here. Additionally, many other known compounds were obtained from the ethyl acetate extract of the culture. Their structures were established on the basis of various spectral data, and their origin is discussed. All compounds were inactive against a range of bacteria and fungi.
Veluri
Ravikanth
R
Department of Organic Chemistry, University of Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
Oka
Imelda
I
Wagner-Döbler
Irene
I
Laatsch
Hartmut
H
D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D009089:Mucor / Q000187:drug effects; D009659:North Sea; D019906:Nuclear Magnetic Resonance, Biomolecular; D013211:Staphylococcus aureus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects; D014736:Vibrio parahaemolyticus / Q000737:chemistry*
D026121:Indole Alkaloids