title: Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects.
abstract: A novel non-vanilloid VR1 antagonist consisting of a new vanilloid equivalent exhibits excellent analgesic effects as well as highly potent antagonistic activities in both capsaicin single channel and calcium uptake assays. In addition, the structural requirement for the vanilloid equivalent of the potent VR1 antagonist has also been elucidated.
authors.affiliation: College of Pharmacy, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742, South Korea. ygsuh@snu.ac.kr
authors.forename: Young-Ger
authors.initials: YG
authors.lastname: Suh
authors.forename: Yong-Sil
authors.initials: YS
authors.lastname: Lee
authors.forename: Kyung-Hoon
authors.initials: KH
authors.lastname: Min
authors.forename: Ok-Hui
authors.initials: OH
authors.lastname: Park
authors.forename: Ho-Sun
authors.initials: HS
authors.lastname: Seung
authors.forename: Hee-Doo
authors.initials: HD
authors.lastname: Kim
authors.forename: Hyoung-Geun
authors.initials: HG
authors.lastname: Park
authors.forename: J- Yeon
authors.initials: J
authors.lastname: Choi
authors.forename: Jeewoo
authors.initials: J
authors.lastname: Lee
authors.forename: Sang-Wook
authors.initials: SW
authors.lastname: Kang
authors.forename: Uh-taek
authors.initials: UT
authors.lastname: Oh
authors.forename: Jae-yeon
authors.initials: JY
authors.lastname: Koo
authors.forename: Yung-Hyup
authors.initials: YH
authors.lastname: Joo
authors.forename: Sun-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Jin Kwan
authors.initials: JK
authors.lastname: Kim
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Park
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002211:Capsaicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D010146:Pain / Q000517:prevention & control; D011955:Receptors, Drug / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D011955:Receptors, Drug; D002211:Capsaicin