title: An air quality data analysis system for interrelating effects, standards, and needed source reductions: Part 13--Applying the EPA Proposed Guidelines for Carcinogen Risk Assessment to a set of asbestos lung cancer mortality data.
abstract: The Clean Air Act Amendments of 1990 (CAAA-90) list 189 hazardous air pollutants (HAPs) for which "safe" ambient concentrations are to be determined. The primary purpose of this paper is to develop two mathematical models, lognormal and logarithmic, that effectively express excess lung cancer mortality as a function of asbestos concentration for an example set of data and also to suggest using these two models for additional HAPs. The secondary purpose of this paper is to calculate a "safe" asbestos concentration by first assuming a default linear extrapolation (to one excess death per million people, as specified for carcinogenic HAPs). The resulting "safe" concentration is an impossible-to-achieve 1/1000 of present background asbestos concentrations. A letter to the editor and a response in this Journal issue use additional asbestos data that suggest that the "safe" concentration should be about 730 times higher than first calculated here and that a default nonlinear extrapolation should be used instead, with the "safe" concentration proportional to the desired mortality level raised to the 0.39 power. These results suggest that the most important problem in setting a "safe" concentration for each carcinogenic HAP is to determine the correct nonlinear extrapolation to use for each HAP.
authors.affiliation: Exposure Modeling Research Branch, Human Exposure and Atmospheric Sciences Division, National Exposure Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.
authors.forename: Ralph I
authors.initials: RI
authors.lastname: Larsen
mesh_terms: D001194:Asbestos / Q000009:adverse effects* / Q000032:analysis*; D004777:Environment; D004781:Environmental Exposure; D004784:Environmental Monitoring; D004787:Environmental Pollution / Q000517:prevention & control; D017408:Guidelines as Topic; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000401:mortality*; D008962:Models, Theoretical; D011634:Public Health; D018570:Risk Assessment; D012449:Safety; D014481:United States; D014484:United States Environmental Protection Agency
chemical_list: D001194:Asbestos