Interleukin-10 and pathogenesis of murine ocular toxoplasmosis.
To understand the role of interleukin-10 (IL-10) in ocular toxoplasmosis, we compared C57BL/6 (B6) and BALB/c background mice lacking a functional IL-10 gene (IL-10(-/-)) and B6 transgenic mice expressing IL-10 under the control of the IL-2 promoter. Increased cellular infiltration and necrosis were observed in the eye tissue of IL-10(-/-) mice of both the B6 and BALB/c backgrounds with associated changes in the levels of cytokines in serum. In contrast, there was no evidence of necrosis in the eye tissue from IL-10 transgenic mice following parasite exposure. Our results demonstrate that IL-10 is important in the regulation of inflammation during acute ocular toxoplasmosis.
Lu
Fangli
F
Department of Medicine and Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA.
Huang
Shiguang
S
Kasper
Lloyd H
LH
D000818:Animals; D004195:Disease Models, Animal; D005123:Eye / Q000473:pathology; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D014122:Toxoplasma / Q000472:pathogenicity; D014126:Toxoplasmosis, Ocular / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*
D016753:Interleukin-10