Enzyme-prodrug systems: thymidine phosphorylase/5'-deoxy-5-fluorouridine.
Evrard
Alexandre
A
Department of Toxicology, Faculty of Pharmacy, University of Montpellier, Montpellier, France.
Ciccolini
Joseph
J
Cuq
Pierre
P
Cano
Jean-Paul
JP
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001711:Biotransformation; D002460:Cell Line; D018920:Coculture Techniques; D018076:DNA, Complementary / Q000493:pharmacokinetics; D005467:Floxuridine / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005472:Fluorouracil / Q000493:pharmacokinetics; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D008322:Mammals; D015183:Restriction Mapping; D013939:Thymidine Phosphorylase / Q000235:genetics* / Q000378:metabolism*; D014162:Transfection / Q000379:methods*; D014316:Tritium; D014407:Tumor Cells, Cultured
D000964:Antimetabolites, Antineoplastic; D018076:DNA, Complementary; D005467:Floxuridine; D014316:Tritium; D013939:Thymidine Phosphorylase; D005472:Fluorouracil