title: Rosai-Dorfman disease of the pleura: a rare extranodal presentation.
abstract: We present a case of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) manifesting primarily as a pleural disease without involvement of the lung parenchyma. The patient is an 81-year-old man who presented with increasing shortness of breath. Radiographic studies revealed a large loculated left-sided pleural effusion and parietal pleural thickening. Video-assisted thoracoscopic biopsy of the pleura showed the characteristic S100-positive histiocytes exhibiting emperipolesis. In this rare case of pleural Rosai-Dorfman disease, the extensive involvement of the pleural lymphatics by the characteristic histiocytes appears to have been responsible for the pleural effusion.
authors.affiliation: Department of Pathology, University of Pittsburgh School of Medicine and UPMC-Presbyterian, PA 15213, USA.
authors.forename: N Paul
authors.initials: NP
authors.lastname: Ohori
authors.forename: Jing
authors.initials: J
authors.lastname: Yu
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Landreneau
authors.forename: F Leland
authors.initials: FL
authors.lastname: Thaete
authors.forename: Kevin
authors.initials: K
authors.lastname: Kane
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D006644:Histiocytes / Q000378:metabolism / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D010995:Pleural Diseases / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D010996:Pleural Effusion / Q000209:etiology; D009418:S100 Proteins / Q000378:metabolism
chemical_list: D009418:S100 Proteins