Factors associated with the development of chorioretinal atrophy around choroidal neovascularization in pathologic myopia.
OBJECTIVE
To examine the influencing factors on the development of chorioretinal atrophy, which is the main cause of long-term visual decrease in myopic choroidal neovascularization (CNV), in a large series of highly myopic patients.


METHODS
Sixty-five patients (81 eyes) with myopic CNV were studied retrospectively. The influence of the patient's age, refractive error, axial length, visual acuity at onset of CNV, size of CNV, and grade of myopic retinopathy on the extent of chorioretinal atrophy more than 3 years after CNV onset was investigated by means of multiple linear regression analysis.


RESULTS
Seventy-seven of 81 eyes (95.1%) developed chorioretinal atrophy around myopic CNV during the follow-up period. Multiple linear regression revealed that age was the most influencing factor for the development of chorioretinal atrophy in all the subjects. When we divided the subjects into two groups according to their age, however, CNV size was the only factor to influence the development of chorioretinal atrophy in the patients younger than 40 years, whereas age was still the only influencing factor in those older than 40 years.


CONCLUSIONS
The factors influencing the development of chorioretinal atrophy differ according to patient age. Local factors, such as CNV size, determine the tendency to develop chorioretinal atrophy in young patients. Systemic factors, such as patient age, play a greater part in older subjects.
Kojima
Ariko
A
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo , Japan.
Ohno-Matsui
Kyoko
K
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo , Japan. k.ohno.oph@med.tmd.ac.jp.
Teramukai
Satoshi
S
Division of Clinical Trial Design and Management, Translational Research Center, Kyoto University Hospital, Kyoto, Japan.
Yoshida
Takeshi
T
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo , Japan.
Ishihara
Yoko
Y
Department of Hygiene and Public Health, School of Medicine, Tokyo Women's Medical University, Tokyo, Japan.
Kobayashi
Kanako
K
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo , Japan.
Shimada
Noriaki
N
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo , Japan.
Yasuzumi
Kenjiro
K
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo , Japan.
Futagami
Soh
S
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo , Japan.
Tokoro
Takashi
T
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo , Japan.
Mochizuki
Manabu
M
Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo , Japan.
D001284:Atrophy; D002829:Choroid / Q000473:pathology*; D020256:Choroidal Neovascularization / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000150:complications*; D012160:Retina / Q000473:pathology*; D012189:Retrospective Studies; D012307:Risk Factors; D014792:Visual Acuity