title: Association study of the human FZD3 locus with schizophrenia.
abstract: The FZD3 protein is a transmembrane receptor for secreted Wnt glycoproteins involved in the Wnt signal transduction cascades. The alteration of Wnt signal transduction cascades has been thought to be involved in producing the cytoarchitectural defects observed in schizophrenia. Because the human FZD3 gene is mapped to chromosome 8p21, which is a potential region containing a gene for schizophrenia, it may play a role in conferring susceptibility to the disease. This study was conducted with the detection of three single nucleotide polymorphisms (SNPs) located within the FZD3 locus by using the polymerase chain reaction-based restriction fragment length polymorphism (RFLP) analysis among 246 schizophrenic family trios of Chinese Han descent.The transmission disequilibrium test (TDT) demonstrated that the three SNPs all showed a preferential transmission with a p value ranging from.0003-.000007. The global chi-squared test for haplotype transmission also showed a strong association (chi(2) = 48.84, df = 7, p <.000001).The strong association between the FZD3 locus and schizophrenia suggests that the gene itself may play a role in underlying schizophrenia, although a nearby gene responsible for predisposing to the illness cannot be ruled out.
authors.affiliation: Institute of Mental Health, Peking University, Beijing, China.
authors.forename: Jianzhong
authors.initials: J
authors.lastname: Yang
authors.forename: Tianmei
authors.initials: T
authors.lastname: Si
authors.forename: Yansu
authors.initials: Y
authors.lastname: Ling
authors.forename: Yan
authors.initials: Y
authors.lastname: Ruan
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Han
authors.forename: Xiling
authors.initials: X
authors.lastname: Wang
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhang
authors.forename: Qingmei
authors.initials: Q
authors.lastname: Kong
authors.forename: Xueni
authors.initials: X
authors.lastname: Li
authors.forename: Cui
authors.initials: C
authors.lastname: Liu
authors.forename: Darong
authors.initials: D
authors.lastname: Zhang
authors.forename: Mo
authors.initials: M
authors.lastname: Zhou
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Yu
authors.forename: Shuzeng
authors.initials: S
authors.lastname: Liu
authors.forename: Liang
authors.initials: L
authors.lastname: Shu
authors.forename: Dalong
authors.initials: D
authors.lastname: Ma
authors.forename: Jun
authors.initials: J
authors.lastname: Wei
authors.forename: Dai
authors.initials: D
authors.lastname: Zhang
mesh_terms: D002898:Chromosomes, Human, Pair 8; D005260:Female; D051157:Frizzled Receptors; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D043562:Receptors, G-Protein-Coupled / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: C105574:FZD3 protein, human; D051157:Frizzled Receptors; D043562:Receptors, G-Protein-Coupled