title: Antimicrobial compounds from Pimpinella species growing in Turkey.
abstract: A new, 4-(2-propenyl)-phenyl angelate ( 1) and four known phenylpropanoids ( 2 - 5), were isolated from Pimpinella isaurica, a species endemic in Turkey. One new sesquiterpene, 1-methyl-4-(5-methyl-1-methylenehex-4-enyl)-7-oxabicyclo[4.1.0]heptane ( 6) was obtained from P. aurea and two known phenylpropanoids were isolated ( 7, 8), from P. corymbosa. The structure elucidation of the new compounds 1 and 6 was achieved by a combination of one- ( (1)H, and (13)C) and two-dimensional NMR techniques (G-DQF-COSY, G-HMQC, and G-HMBC) and LC-ESI-FTMS. Compounds 1, 2, 4, 6, 7, 8 have been evaluated for their antimalarial and antimicrobial activities. Compound 1, 2, 4, 6, 8 had antimicrobial activity against Mycobacterium intracellulare with IC (50) values of 7.0, 15.0, 2.5, 10.0 and 1.5 microg/mL, respectively.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
authors.forename: Nurhayat
authors.initials: N
authors.lastname: Tabanca
authors.forename: Erdal
authors.initials: E
authors.lastname: Bedir
authors.forename: Nese
authors.initials: N
authors.lastname: Kirimer
authors.forename: K Husnu Can
authors.initials: KH
authors.lastname: Baser
authors.forename: Shabana I
authors.initials: SI
authors.lastname: Khan
authors.forename: Melissa R
authors.initials: MR
authors.lastname: Jacob
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D015269:Mycobacterium avium Complex / Q000187:drug effects*; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D028042:Pimpinella; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D000962:Antimalarials; D010936:Plant Extracts