title: Abnormal ocular pigment deposition and glaucoma in the dog.
abstract: The combined occurrence of ocular pigment deposition and glaucoma has been described in Cairn Terriers. Recently, this condition was also observed in two other breeds: the Boxer (two cases) and the Labrador Retriever (one case). Six dogs were referred to the Ophthalmology section of the Department of Clinical Sciences of Companion Animals and to a private referral clinic because of glaucoma or blindness in one or both eyes. In five cases ophthalmic examination showed pigment depositions in the sclera around the entire circumference of the perilimbal zone. Eight enucleated eyes (four eyes of two Cairn Terriers, three eyes of two Boxers and one eye of a Labrador Retriever) were examined microscopically. All eyes showed the same findings: an extensive infiltration of large melanin-containing cells with an eccentric nucleus, located in the iris, ciliary body, retina, choroids and sclera. Transmission electron microscopy of two of the examined eyes revealed that the morphology of most of these cells was consistent with melanophages. While reports in the veterinary literature concerning this condition are limited the cells concerned have been described to be melanocytes. Further research is needed to conclusively identify the cell type. As described in the present report, the histologic and transmission electron microscopic findings suggest a different etiology of the ocular pigment deposition and glaucoma compared with the pigment dispersal syndrome in humans.
authors.affiliation: Ophthalmology Section, Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, the Netherlands. rromvdsandt@wxs.nl
authors.forename: Roswitha R O M
authors.initials: RR
authors.lastname: van de Sandt
authors.forename: Michael H
authors.initials: MH
authors.lastname: Boevé
authors.forename: Frans C
authors.initials: FC
authors.lastname: Stades
authors.forename: Maria J L
authors.initials: MJ
authors.lastname: Kik
mesh_terms: D000818:Animals; D003315:Cornea / Q000648:ultrastructure; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D004285:Dogs; D005260:Female; D005901:Glaucoma / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D007498:Iris / Q000648:ultrastructure; D008297:Male; D010375:Pedigree; D010857:Pigment Epithelium of Eye / Q000002:abnormalities* / Q000648:ultrastructure; D010859:Pigmentation Disorders / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D012590:Sclera / Q000648:ultrastructure