title: Design and syntheses of melanocortin subtype-4 receptor agonists: evolution of the pyridazinone archetype.
abstract: The discovery and optimization of a new class of non-peptidyl, pyridazinone derived melanocortin subtype-4 receptor agonists is disclosed.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065-0900, USA. f_ujjainwalla@merck.com
authors.forename: Feroze
authors.initials: F
authors.lastname: Ujjainwalla
authors.forename: Daniel
authors.initials: D
authors.lastname: Warner
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Walsh
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Wyvratt
authors.forename: Changyou
authors.initials: C
authors.lastname: Zhou
authors.forename: Lihu
authors.initials: L
authors.lastname: Yang
authors.forename: Rubana N
authors.initials: RN
authors.lastname: Kalyani
authors.forename: Tanya
authors.initials: T
authors.lastname: MacNeil
authors.forename: Lex H T
authors.initials: LH
authors.lastname: Van der Ploeg
authors.forename: Charles I
authors.initials: CI
authors.lastname: Rosenblum
authors.forename: Rui
authors.initials: R
authors.lastname: Tang
authors.forename: Aurawan
authors.initials: A
authors.lastname: Vongs
authors.forename: David H
authors.initials: DH
authors.lastname: Weinberg
authors.forename: Mark T
authors.initials: MT
authors.lastname: Goulet
mesh_terms: D000818:Animals; D001665:Binding Sites; D006801:Humans; D007202:Indicators and Reagents; D007700:Kinetics; D051379:Mice; D008968:Molecular Conformation; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D044105:Receptor, Melanocortin, Type 4 / Q000819:agonists*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D007202:Indicators and Reagents; D011724:Pyridazines; D044105:Receptor, Melanocortin, Type 4