Urinary extracellular matrix measurement as a reliable and cost effective diagnostic tool for bladder tumors.
Although numerous markers for bladder tumor (BT) have been investigated, a more effective, less expensive test is needed. To address this issue, we examined the urinary extracellular matrix (U-ECM) measurement in urine from patients with BT, and investigated the U-ECM measurement and its correlation with tumor grade and invasion. We also investigated the U-ECM measurement to ascertain the condition of the bladder wall injured by transurethral resection of bladder tumor (TUR-bt). Fresh urine samples were obtained from 170 patients with BT, 38 patients with chronic cystitis (CC) and 50 with normal bladder (NB). U-ECM measurements were higher in BT groups than in CC and in NB groups. There was no significant difference in the U-ECM measurement between grades. However, in another comparison between stages, U-ECM measurements were higher in advanced cancer than in early stage cancer. After surgery, U-ECM concentration increased on day 1 and levels of U-ECM that were higher prior to TUR-bt continued to increase until day 6. U-ECM continued to decrease after day 6 and reached normal range on day 14. Our results demonstrated that measurement of U-ECM is a highly efficient, reliable and cost effective marker for screening and monitoring bladder tumors and is also a beneficial diagnostic tool. Evaluation of the results is relatively simple and accurate and the running cost of measuring U-ECM is significantly lower than other tests.
Yoshimura
Rikio
R
Department of Urology, Osaka City University Hospital, Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno, Osaka 545-8585, Japan. jasmin@med.osaka-cu.ac.jp
Wada
Seiji
S
Matsuyama
Masahide
M
Hase
Taro
T
Goto
Takeshi
T
Tanaka
Tomoaki
T
Kuratsukuri
Katsuyuki
K
Tsuchida
Kenji
K
Nakatani
Tatsuya
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005109:Extracellular Matrix / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D001743:Urinary Bladder / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis*; D014556:Urine / Q000502:physiology*