title: Insecticidal activity of the enantiomers of fipronil.
abstract: The two enantiomers of the insecticide fipronil were made by preparative HPLC. The insecticidal activities of the racemic mixture and the two enantiomers against selected agricultural or household pests (cotton stainer, Dysdercus cingulatus F; grain weevil, Sitophilus granarius L and house fly, Musca domestica L) were determined. There was no significant difference in acute or residual activity between the racemic mixture and the enantiomers of fipronil, indicating that there is no preferred chiral form of the compound in these key species of important insects. This observation clearly suggests that there is no major scope for marketing the insecticide in a one-enantiomer form.
authors.affiliation: Cheminova A/S, PO Box 9, DK-7620 Lemvig, Denmark. hbt@cheminova.dk
authors.forename: Harald B
authors.initials: HB
authors.lastname: Teicher
authors.forename: Britt
authors.initials: B
authors.lastname: Kofoed-Hansen
authors.forename: Niels
authors.initials: N
authors.lastname: Jacobsen
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D001517:Coleoptera / Q000187:drug effects; D005260:Female; D020062:Heteroptera / Q000187:drug effects; D006793:Houseflies / Q000187:drug effects; D007313:Insecta / Q000187:drug effects*; D007306:Insecticides / Q000138:chemical synthesis / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D011720:Pyrazoles / Q000138:chemical synthesis / Q000633:toxicity*; D013237:Stereoisomerism
chemical_list: D007306:Insecticides; D011720:Pyrazoles; C082360:fipronil