title: Inflammation, homocysteine, and vitamin B6 status after ischemic stroke.
abstract: OBJECTIVE
  Epidemiological studies have described an association between low vitamin B6 (measured as pyridoxal 5'-phosphate [PLP]) and ischemic stroke, independent of homocysteine (tHcy). We investigated B6 status, tHcy, and inflammation (measured by C-reactive protein [CRP]) in patients with stroke and controls.
  
  
  METHODS
  Consecutive cases with new ischemic stroke were compared with matched controls. Fasting tHcy, PLP, and CRP were measured.
  
  
  RESULTS
  The adjusted odds ratio of low PLP in the highest compared with the lowest CRP quartile was 16.6 (2, 139.9, P=0.01). Age, CRP, supplemental vitamin use, and albumin were independent predictors of PLP (P<0.05 for all). No relationship was observed between CRP and tHcy.
  
  
  CONCLUSIONS
  The relationship between inflammation and low B6 status may partially explain the findings of previous epidemiological studies.
authors.affiliation: Stroke Service, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Fruit St, Boston, Mass 02114, USA. pjkelly@partners.org
authors.forename: P J
authors.initials: PJ
authors.lastname: Kelly
authors.forename: J P
authors.initials: JP
authors.lastname: Kistler
authors.forename: V E
authors.initials: VE
authors.lastname: Shih
authors.forename: R
authors.initials: R
authors.lastname: Mandell
authors.forename: N
authors.initials: N
authors.lastname: Atassi
authors.forename: M
authors.initials: M
authors.lastname: Barron
authors.forename: H
authors.initials: H
authors.lastname: Lee
authors.forename: S
authors.initials: S
authors.lastname: Silveira
authors.forename: K L
authors.initials: KL
authors.lastname: Furie
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D002097:C-Reactive Protein / Q000032:analysis; D015897:Comorbidity; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D008297:Male; D015999:Multivariate Analysis; D016017:Odds Ratio; D011732:Pyridoxal Phosphate / Q000097:blood* / Q000172:deficiency; D020521:Stroke / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D026681:Vitamin B 6 Deficiency / Q000453:epidemiology*
chemical_list: D006710:Homocysteine; D011732:Pyridoxal Phosphate; D002097:C-Reactive Protein