C-C chemokine receptor 2 gene polymorphism in Japanese patients with multiple sclerosis.
C-C chemokine receptor 2 (CCR2) is a receptor for chemoattractant protein-1 (MCP-1) and associated with infiltrating lymphocytes in chronic active multiple sclerosis (MS) lesions. To study the role of CCR2 gene in the development of MS, we investigated the CCR2-64I polymorphism in 122 MS patients and 112 healthy controls in a Japanese population. We also analysed the influence of CCR2-64I polymorphism on the clinical course, age at disease onset, and severity. The distribution of the CCR2-64I allele was significantly different between patients and controls (p=0.0187), and the 64I/64I homozygote was significantly less common in MS than in control. Logistic analysis, adjusted for HLA-DRB1*1501-positivity, revealed negative association between the CCR2-64I and MS (p=0.0204). There were no significant associations between CCR2 polymorphism and the clinical features of MS. Our results indicate that the presence of CCR2-64I allele seems to provide protection against the development of MS.
Miyagishi
Ryuji
R
Department of Neurology, Hokkaido University Graduate School of Medicine, Kita-15 Nishi-7, Kita, Sapporo 060-8638, Hokkaido, Japan.
Niino
Masaaki
M
Fukazawa
Toshiyuki
T
Yabe
Ichiro
I
Kikuchi
Seiji
S
Tashiro
Kunio
K
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000483:Alleles; D000704:Analysis of Variance; D044466:Asian People / Q000235:genetics; D019742:Chemokines, CC / Q000378:metabolism*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D054390:Receptors, CCR2; D019707:Receptors, Chemokine / Q000235:genetics*; D012720:Severity of Illness Index
C515334:CCR2 protein, human; D019742:Chemokines, CC; D054390:Receptors, CCR2; D019707:Receptors, Chemokine