title: Trends of oral and oropharyngeal cancer survival over five decades in 3267 patients treated in a single institution.
abstract: The objective of this study was to analyze the influence of changes in the treatment on the prognosis of patients treated over 44 years in a single institution. The 5-decade trends in treatment approach and 5-year survival of 3267 patients treated between 1953 and 1997 were analyzed. An increase was observed in primary surgical treatment and its association with radiotherapy. In the 1950s, 29.1% of the patients were treated by surgery, 54.5% by radiotherapy and 16.4% by combined treatment; in the 1990s, these proportions were 39.7, 9.7 and 50.6%, respectively (P<0.001). There was a significant increase in the 5-year survival rates from 28.7% for patients treated in the 1950s to 43.2% in the 1990s (P<0.001). The changes in treatment approach for oral and oropharyngeal cancer over the last 5 decades, with an increase of surgical treatment and its combination with radiotherapy significantly improved the survival rates.
authors.affiliation: Head and Neck Surgery and Otorhinolaringology Department Centro de Tratamento e Pesquisa, Hospital do Câncer AC Camargo Rua Professor Antonio Prudente, 211, São Paulo 01509-010, Brazil.
authors.forename: André L
authors.initials: AL
authors.lastname: Carvalho
authors.forename: Mauro K
authors.initials: MK
authors.lastname: Ikeda
authors.forename: José
authors.initials: J
authors.lastname: Magrin
authors.forename: Luiz P
authors.initials: LP
authors.lastname: Kowalski
mesh_terms: D001938:Brazil / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D009959:Oropharyngeal Neoplasms / Q000401:mortality* / Q000532:radiotherapy / Q000601:surgery; D011379:Prognosis; D012044:Regression Analysis; D016019:Survival Analysis; D015996:Survival Rate