title: Enhanced phagocytosis of Candida species mediated by opsonization with a recombinant human antibody single-chain variable fragment.
abstract: Specific antibody opsonization significantly enhances the level of phagocytosis of Candida in the absence of complement. Furthermore, we have described a system using a recombinant human antibody single-chain variable fragment that allows a comparative study of phagocytosis of multiple Candida species opsonized via a common antigen.
authors.affiliation: Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA.
authors.forename: Melanie
authors.initials: M
authors.lastname: Wellington
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Bliss
authors.forename: Constantine G
authors.initials: CG
authors.lastname: Haidaris
mesh_terms: D000908:Antibodies, Fungal / Q000235:genetics / Q000276:immunology; D002175:Candida / Q000145:classification* / Q000276:immunology*; D006801:Humans; D007128:Immunoglobulin Fragments / Q000235:genetics / Q000276:immunology*; D007135:Immunoglobulin Variable Region; D009000:Monocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D009895:Opsonin Proteins / Q000378:metabolism*; D010587:Phagocytosis; D011994:Recombinant Proteins / Q000276:immunology*
chemical_list: D000908:Antibodies, Fungal; D007128:Immunoglobulin Fragments; D007135:Immunoglobulin Variable Region; D009895:Opsonin Proteins; D011994:Recombinant Proteins