[Types of biochemical response to acute pharmacological indomethacin probe in healthy volunteers].
By the type of biochemical response to acute pharmacological indomethacin probe, a group of both male and female healthy volunteers can be subdivided into two parts. The first part includes volunteers with a stability index reduced as a result of accumulation of the oxidized products and a decrease in the content of reduced glutathione (GSH). The second part includes volunteers with the stability index increased as a result of decrease in the amount of lipid peroxidation products and an increase in the GSH content. A difference between males and females with respect to the response type consisted in that females features changes in the gutathione buffer components, and males, in the activity of antioxidant enzymes (catalase and peroxidase).
Ziganshina
L E
LE
Department of Clinical Pharmacology and Pharmacotherapy, Kazan State Medical Academy, ul. Mushtari 11, Kazan, Tatarstan, 420012 Russia.
Titarenko
A F
AF
Valeeva
I Kh
IKh
Ziganshin
A U
AU
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D002374:Catalase / Q000097:blood; D005260:Female; D005767:Gastrointestinal Diseases / Q000097:blood / Q000139:chemically induced / Q000378:metabolism; D005978:Glutathione / Q000097:blood; D006801:Humans; D007213:Indomethacin / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D009195:Peroxidase / Q000097:blood
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D015415:Biomarkers; D008054:Lipid Peroxides; D002374:Catalase; D009195:Peroxidase; D005978:Glutathione; D007213:Indomethacin