Antifungal 3-hydroxy fatty acids from Lactobacillus plantarum MiLAB 14.
We report the identification and chemical characterization of four antifungal substances, 3-(R)-hydroxydecanoic acid, 3-hydroxy-5-cis-dodecenoic acid, 3-(R)-hydroxydodecanoic acid and 3-(R)-hydroxytetradecanoic acid, from Lactobacillus plantarum MiLAB 14. The concentrations of the 3-hydroxy fatty acids in the supernatant followed the bacterial growth. Racemic mixtures of the saturated 3-hydroxy fatty acids showed antifungal activity against different molds and yeasts with MICs between 10 and 100 micrograms ml-1.
Sjögren
Jörgen
J
Department of Chemistry, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden. jorgen.sjogren@kemi.slu.se
Magnusson
Jesper
J
Broberg
Anders
A
Schnürer
Johan
J
Kenne
Lennart
L
D000935:Antifungal Agents / Q000494:pharmacology*; D017077:Culture Media, Conditioned; D003652:Decanoic Acids / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D007778:Lactobacillus / Q000235:genetics / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D029592:Oleaceae / Q000382:microbiology; D017422:Sequence Analysis, DNA
D000935:Antifungal Agents; D017077:Culture Media, Conditioned; D003652:Decanoic Acids