title: Tongue cancer: do patients younger than 40 do worse?
abstract: BACKGROUND
  Debate continues as to whether being young confers a worse prognosis for patients with squamous cell carcinoma of the tongue. Recent papers have provided conflicting views in this debate. In this study we aimed to investigate if young age at the time of diagnosis of squamous cell carcinoma of the tongue confers a worse prognosis.
  
  
  METHODS
  Eligible patients were identified through the computer database of the Department of Radiation Oncology, Westmead Hospital, Sydney. All eligible patients were treated with radical intent. Using age 40 as a cut off multivariate and survival analysis was undertaken to compare age groups.
  
  
  RESULTS
  Median age at diagnosis was 60 years (range, 19-86 years) in 84 males (65 per cent) and 45 females (35 per cent). Median follow-up time was 43 months (range, 2.3-203 months). Fifteen patients (12 per cent) were aged <40 years. On univariate analysis stage and age were significant determinants of disease-specific survival. There was no difference in overall survival between the young (<40 years) and middle-aged groups (40-60 years). However, the young and the middle aged were both more likely to survive than the older age group (>60 years). On multivariate analysis age remained a significant factor for determining disease-specific survival, with the older age group 2.9 times more likely to die than the younger groups.
  
  
  CONCLUSIONS
  Young age (<40 years) did not portend to worse survival in comparison to older tongue cancer patients.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Westmead Hospital, Sydney.
authors.forename: D M
authors.initials: DM
authors.lastname: Hyam
authors.forename: R C
authors.initials: RC
authors.lastname: Conway
authors.forename: Y
authors.initials: Y
authors.lastname: Sathiyaseelan
authors.forename: V
authors.initials: V
authors.lastname: Gebski
authors.forename: G J
authors.initials: GJ
authors.lastname: Morgan
authors.forename: D M
authors.initials: DM
authors.lastname: Walker
authors.forename: M J
authors.initials: MJ
authors.lastname: Veness
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking; D000704:Analysis of Variance; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000628:therapy; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012907:Smoking; D016019:Survival Analysis; D014062:Tongue Neoplasms / Q000175:diagnosis* / Q000628:therapy