Molecular cloning of PP2Ceta, a novel member of the protein phosphatase 2C family.
We have cloned a novel member of the mouse protein phosphatase 2C family, PP2Ceta. Sequence analysis suggests that PP2Ceta, PP2Czeta and NERPP-2C constitute a unique subgroup of the PP2C family. PP2Ceta had extremely low activity against alpha-casein compared with PP2Calpha and was localized mainly in cell nuclei, suggesting that PP2Ceta dephosphorylates a unique nuclear protein(s) in the cells.
Komaki
Ken-ichiro
K
Department of Biochemistry, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Katsura
Koji
K
Ohnishi
Motoko
M
Guang Li
Ming
M
Sasaki
Masato
M
Watanabe
Makoto
M
Kobayashi
Takayasu
T
Tamura
Shinri
S
D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D020224:Expressed Sequence Tags; D008969:Molecular Sequence Data; D010749:Phosphoprotein Phosphatases / Q000235:genetics*; D000071636:Protein Phosphatase 2C
D010749:Phosphoprotein Phosphatases; D000071636:Protein Phosphatase 2C