title: Effects of intake of a mixture of thiamin, arginine, caffeine, and citric acid on adiposity in healthy subjects with high percent body fat.
abstract: We assessed the effects of intake of thiamin, arginine, caffeine, and citric acid (TACC) on lipid metabolism in healthy subjects. Thirty-one subjects with high percent body fat (> or = 25.0%) were randomly assigned to a 12-wk intervention with daily intake of TACC-supplemented tea (1.1, 1240, 52, and 540 mg, respectively; n=16) or control tea (n=15). The percent body fat decreased significantly during the intervention in both groups, especially in the TACC group. A percentage decrease in triceps skinfold was significantly greater in the TACC group than in the control group. The decrease in abdominal visceral fat in obese subjects was significantly greater in the TACC group than in the control group. Serum triglyceride was significantly lower during intervention than that during the non-intervention period in the TACC group. These results suggest that TACC may be effective in reducing body fat in obese subjects.
authors.affiliation: Research and Development Section, Takeda Food Products Ltd., Imoji, Itami, Japan. k_muroyama@mti.biglobe.ne.ne
authors.forename: Koutarou
authors.initials: K
authors.lastname: Muroyama
authors.forename: Shinji
authors.initials: S
authors.lastname: Murosaki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Ishijima
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Toh
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology* / Q000187:drug effects; D000328:Adult; D001120:Arginine / Q000378:metabolism* / Q000494:pharmacology; D015992:Body Mass Index; D002110:Caffeine / Q000493:pharmacokinetics* / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D019343:Citric Acid / Q000378:metabolism* / Q000494:pharmacology; D019587:Dietary Supplements; D002149:Energy Intake; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D013831:Thiamine / Q000493:pharmacokinetics* / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D014280:Triglycerides; D019343:Citric Acid; D002110:Caffeine; D001120:Arginine; D002784:Cholesterol; D013831:Thiamine