Surgical approaches and intestinal transplantation.
The surgical treatment of short-bowel syndrome has been traditionally based on the correction of mechanical obstruction, which is responsible for bacterial overgrowth syndrome, or on intestinal expansion procedures. Since the introduction of clinical intestinal transplantation by Lillehei in 1964, there have been remarkable advances in the immunosuppressive regimens to control rejection and in preservation techniques, monitoring and critical care. Newer and more powerful immunosuppressants have helped to transform intestinal transplantation into a clinical reality-transplantation can now be a life-saving procedure for patients with intestinal failure. It is currently indicated in the event of life-threatening complications of an underlying disease or from total parenteral nutrition (TPN). Rehabilitation in successful cases is excellent.
Benedetti
Enrico
E
University of Illinois at chicago, 1Division of Transplantation, 840 S. Wood St., Chicago, IL 60612, USA. enrico@uic.edu
Panaro
Fabrizio
F
Holterman
Mark
M
Abcarian
Herand
H
D000465:Algorithms; D002102:Cadaver; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000601:surgery* / Q000637:transplantation; D019520:Living Donors; D016377:Organ Transplantation / Q000379:methods; D010289:Parenteral Nutrition, Total / Q000009:adverse effects; D011788:Quality of Life; D012778:Short Bowel Syndrome / Q000601:surgery*; D009927:Tissue and Organ Procurement