title: Cdk5 and the mystery of synaptic vesicle endocytosis.
abstract: Regulation of endocytosis by protein phosphorylation and dephosphorylation is critical to synaptic vesicle recycling. Two groups have now identified the neuronal kinase Cdk5 (cyclin-dependent kinase 5) as an important regulator of this process. Robinson and coworkers recently demonstrated that Cdk5 is necessary for synaptic vesicle endocytosis (SVE) (Tan et al., 2003), whereas a new report in this issue claims that Cdk5 negatively regulates SVE (Tomizawa et al., 2003). Careful examination of the data reveals a model that helps resolve the apparently contradictory nature of these reports.
authors.affiliation: Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9070, USA.
authors.forename: Chan
authors.initials: C
authors.lastname: Nguyen
authors.forename: James A
authors.initials: JA
authors.lastname: Bibb
mesh_terms: D000818:Animals; D051360:Cyclin-Dependent Kinase 5; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D034281:Dynamins / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D025461:Feedback, Physiological / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D010766:Phosphorylation; D017729:Presynaptic Terminals / Q000201:enzymology* / Q000648:ultrastructure; D013572:Synaptic Vesicles / Q000201:enzymology* / Q000648:ultrastructure
chemical_list: D051360:Cyclin-Dependent Kinase 5; C495905:CDK5 protein, human; D018844:Cyclin-Dependent Kinases; D034281:Dynamins