title: [Autoimmune hepatitis in children and adolescents: clinical study, diagnosis and therapeutic response].
abstract: OBJECTIVE
  The aim of this study was to evaluate the clinical, laboratory and histopathological characteristics and the response to immunosuppression in children and adolescents with autoimmune hepatitis (AIH).
  
  
  METHODS
  The present research is a descriptive study consisting of 39 children and adolescents with AIH who receive care at the Department of Pediatric Gastroenterology of Hospital das Clínicas (UFMG) from 1986 to 1998.
  
  
  RESULTS
  Children's age ranged from 1.6 to 17 years (mean 8.7 +/- 3.49), most of them were females (87.2%). There were three types of clinical presentations: chronic (53.9%), acute (41%), and serious hepatic failure (5.1%). The most relevant laboratory parameters were the aminotransferases and gamma-globulin increase. Antinuclear antibodies were positive in 66.7% of the patients, while smooth muscle antibodies were positive in 52.8% and anti-LKM1 in 3% of the patients. In the histopathology the most important findings were the piecemeal necrosis (93.7%), moderate to severe portal inflammation (78.1%), definitive or incomplete cirrhosis (76.9%), absence of lesion of biliary ducts (93.7%) and presence of rosettes (90.6%). During the treatment, 77.8% obtained complete resolution, associated to side effects in 27.8% of them. Seven patients died (17.9%). During the treatment there was significant z score reduction (p<0.05) for height/age.
  
  
  CONCLUSIONS
  After carrying out this study, we observed that the typical characteristics of AIH were: female sex, several clinical presentations, increased aminotransferase, and hypergammaglobulinemia. Histopathology showed a predominance of incipient and/or definitive cirrhosis associated with moderate to severe portal inflammation and piecemeal necrosis. Treatment using corticosteroids and azathioprine, turned out to be effective. However, the reduction in the height/age z score probably represents an adverse effect of corticoid treatment.
authors.affiliation: Gastroenterologia Pediátrica, Universidade Federal de Minas Gerais, Belo Horizonte, MG. alexfer@net.em.com.br
authors.forename: Alexandre R
authors.initials: AR
authors.lastname: Ferreira
authors.forename: Mariza L V
authors.initials: ML
authors.lastname: Roquete
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Penna
authors.forename: Nivaldo H
authors.initials: NH
authors.lastname: Toppa