Linezolid penetration into bone and joint tissues infected with methicillin-resistant staphylococci.
Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of 35 to 124 min after administration of the preoperative dose, except in bone specimens, where they reached 3.9 +/- 2.0 mg/liter.
Kutscha-Lissberg
Friedrich
F
Department of Surgery-Trauma Center, BG Kliniken Bergmannsheil-Universitätsklinik, Ruhr University, Bochum, Germany. Friedrich.Kutscha-Lissberg@ruhr-uni-bochum.de
Hebler
Ute
U
Muhr
Gert
G
Köller
Manfred
M
D000081:Acetamides / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001842:Bone and Bones / Q000378:metabolism*; D003646:Debridement; D005260:Female; D006801:Humans; D007596:Joints / Q000378:metabolism*; D000069349:Linezolid; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D009336:Necrosis; D023303:Oxazolidinones / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000378:metabolism*
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid