title: The effects of different alcoholic drinks on lipids, insulin and haemostatic and inflammatory markers in older men.
abstract: Light to moderate drinking is associated with lower risk of coronary heart (CHD) than non-drinkers. We have examined the relationships between total alcohol intake and type of alcoholic beverage and several potential biological mechanisms. We carried out the study in 3158 men aged 60-79 years drawn from general practices in 24 British towns with no history of myocardial infarction, stroke or diabetes and who were not on warfarin. Total alcohol consumption showed a significant positive dose-response relationship with high density lipoprotein cholesterol (HDL-C), coagulation factor IX, haematocrit, blood viscosity, and tissue plasminogen (t-PA) antigen, and an inverse dose-response relationship with insulin, fibrinogen, von Willebrand factor (vWF) and triglycerides after adjustment for possible confounders. Total alcohol consumption showed weak associations with plasma viscosity and fibrin D-dimer, and no association with factors VII, VIII, or C-reactive protein (CRP). Wine was specifically associated with lower CRP, plasma viscosity, factor VIII and triglycerides. The findings are consistent with the suggestion that HDL-C in particular but also insulin and haemostatic factors may contribute to the beneficial effect of light to moderate drinking on risk of CHD. Wine has effects that may confer greater protection than other alcoholic beverages.
authors.affiliation: Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill St, London, NW3 2PF, UK. goya@pcps.ucl.ac.uk
authors.forename: Sasiwarang Goya
authors.initials: SG
authors.lastname: Wannamethee
authors.forename: Gordon D O
authors.initials: GD
authors.lastname: Lowe
authors.forename: Gerald
authors.initials: G
authors.lastname: Shaper
authors.forename: Peter H
authors.initials: PH
authors.lastname: Whincup
authors.forename: Ann
authors.initials: A
authors.lastname: Rumley
authors.forename: Mary
authors.initials: M
authors.lastname: Walker
authors.forename: Lucy
authors.initials: L
authors.lastname: Lennon
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000097:blood*; D000434:Alcoholic Beverages; D015415:Biomarkers / Q000097:blood; D001809:Blood Viscosity; D004305:Dose-Response Relationship, Drug; D006487:Hemostasis; D006801:Humans; D007249:Inflammation / Q000097:blood; D007328:Insulin / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014920:Wine
chemical_list: D015415:Biomarkers; D007328:Insulin; D008055:Lipids