title: [Biochemical pharmacological effects of lurongjing on young or old mice].
abstract: OBJECTIVE
  To investigate the effect of Lurongjing (LRJ) on young or old mice.
  
  
  METHODS
  In vivo monoamine oxidase (MAO) and superoxide dismutase(SOD) activities, the contents of monoamines(5-HT, NE, DA), malondialdehyde (MDA), RNA and protein, and the incorporations of [3H] Uridine into RNA and [3H] Leucine into protein in liver tissue were measured.
  
  
  RESULTS
  The inhibition of MAO-B activity and the increase of monoamines(5-HT, DA) level, the increase of RNA and protein level, and the incorporations of [3H] Uridine into RNA and [3H] Leucine into protein in liver tissue, the enhancement of SOD activity and the decrease of MDA content in brain and liver tissues were selectively observed in old mice(24 months) than in young mice(1 month) by LRJ (i.g., 4.0 g/kg) administrated orally for 10 successive days.
  
  
  CONCLUSIONS
  LRJ exhibits some anti-aging effect in old mice.
authors.affiliation: First Affiliated Hospital, Jilin University, Changchun 130021.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Chen
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000378:metabolism; D003670:Deer; D005260:Female; D006733:Horns / Q000737:chemistry*; D008099:Liver / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D008419:Materia Medica; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D008995:Monoamine Oxidase