Predicting glaucomatous sensitivity loss using perimetric color saturation test.
OBJECTIVE
To predict future glaucomatous sensitivity loss using a perimetric color saturation test (PCST) that measures the color saturation discrimination threshold for six hues (red, yellow, green, green-blue, blue, and purple) at 9 degrees in horizontal and 3 degrees in vertical extrafoveal points.


METHODS
This new test was carried out on 31 patients (31 eyes) with early glaucoma or ocular hypertension. The sensitivity loss at the four points approximately 9.5 degrees apart from the fixation point was prospectively evaluated annually for 3 years using the Humphrey Field Analyzer (HFA) program central 30-2. The initial results of PCST and the total deviation (TD) in the follow-up HFA results were compared.


RESULTS
Twenty-seven patients (27 eyes) were followed up for 3 years. The color saturation threshold for six hues was correlated with the TD of HFA results at 108 points in the 27 eyes. The TD was -4 dB or better at the baseline measurement in 91 out of the 108 points. The averaged TD in the second and the third year in the follow-up period decreased below -4 dB in 10 of these 91 points, which were categorized as progression points in relation to the 81 nonprogression points. In the initial PCST, only the saturation threshold for purple was higher in the progression points when compared with the nonprogression points (P=.0004, Mann-Whitney U-test).


CONCLUSIONS
Future sensitivity loss is most likely at the points where the threshold of color saturation discrimination is increased for purple in eyes with early glaucoma or ocular hypertension.
Kogure
Satoshi
S
Department of Ophthalmology, Faculty of Medicine, The University of Yamanashi, Yamanashi, Japan.
Chiba
Tatsuya
T
Saito
Shin
S
Iijima
Hiroyuki
H
Tsukahara
Shigeo
S
D000328:Adult; D000368:Aged; D003118:Color Perception; D003117:Color Vision Defects / Q000209:etiology* / Q000503:physiopathology; D018450:Disease Progression; D005901:Glaucoma / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D009798:Ocular Hypertension / Q000150:complications; D011379:Prognosis; D012684:Sensory Thresholds; D014787:Vision Tests; D058609:Visual Field Tests