title: Detailed analysis of the CD8+ T-cell response following adenovirus vaccination.
abstract: We examined CD8(+) T-cell expansion and function following intramuscular immunization with a recombinant adenovirus. This study has identified a number of properties which may explain the strong immunogenicity of adenovirus vectors: (i) the ability to deliver large amounts of antigen into the lymphoid tissues, (ii) the ability to induce rapid expansion and migration of CD8(+) T cells throughout the lymphatics, and (iii) the ability to produce a sustained, high-level CD8(+) T-cell response.
authors.affiliation: Center for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.
authors.forename: Teng Chih
authors.initials: TC
authors.lastname: Yang
authors.forename: Kelley
authors.initials: K
authors.lastname: Dayball
authors.forename: Yong Hong
authors.initials: YH
authors.lastname: Wan
authors.forename: Jonathan
authors.initials: J
authors.lastname: Bramson
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000276:immunology*; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D005822:Genetic Vectors / Q000008:administration & dosage* / Q000276:immunology*; D006801:Humans; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D010047:Ovalbumin / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology; D019076:Transgenes; D014611:Vaccination
chemical_list: D010047:Ovalbumin