Epidemiology of breast cancer--selected highlights.
The main risk factors for breast cancer can be usefully grouped into four major categories-family history/genetic, reproductive/hormonal, proliferative benign breast pathology, and mammographic density. These factors are briefly reviewed and quantitative estimaters of risk are given. A computer programme for combining them to produce individualized risk profiles is described. The ongoing IBIS-II trial of chemoprevention for high risk postmenopausal women is presented as one approach to managing high risk women.
Cuzick
Jack
J
Cancer Research UK Department of Epidemiology, Mathematics and Statistics, Wolfson Institute of Preventive Medicine, London, UK. jack.cuzick@cancer.org.uk
D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000517:prevention & control; D005260:Female; D006801:Humans; D008327:Mammography; D018570:Risk Assessment; D012307:Risk Factors