title: [Clinical study of yishen jianpi yangxue tongli therapy in treating polycystic ovary syndrome].
abstract: OBJECTIVE
  To observe the effect of Yishen Jianpi Yangxue Tongli Therapy (YJYTT) in treating polycystic ovary syndrome (PCOS) and to explore the therapeutic mechanism of YJYTT.
  
  
  METHODS
  One hundred and seven PCOS patients with syndrome differentiation of TCM as Pi-Shen Yang deficiency were randomly divided into two groups, the treated group (n = 76) was treated with Chinese herbal medicine, while the control group (n = 31) was treated by clomiphen. The therapeutic effect in both groups and the change of body mass index (BMI), Ferriman-Gallway (F-G) score, serum sex hormones and serum oral glucose tolerance test (OGTT) before and after treatment were observed.
  
  
  RESULTS
  The comparison of total effective rate between two groups was insignificantly different, but the pregnancy rate of the treated group (65.7%) was markedly higher than that of control group (25.0%, P < 0.01). Also, significant difference was shown in the aspect of BMI, F-G score, serum testosterone (T), luteinizing hormone (LH) and OGTT, etc. between the two groups (P < 0.05).
  
  
  CONCLUSIONS
  The YJYTT could markedly improve the clinical symptoms and pregnancy rate of PCOS patients, particularly showing good effect to the clomiphen resistant patients. The mechanism possibly was due to its regulation on hypothalamus-pituitary-ovarium axis and reducing the insulin resistance.
authors.affiliation: Department of Gynecology, Beijing Hospital of TCM, Beijing 100010. qiqihualing@yahoo.com.cn
authors.forename: Ling
authors.initials: L
authors.lastname: Hua
authors.forename: Yu-ning
authors.initials: YN
authors.lastname: Wu
authors.forename: Ju-ming
authors.initials: JM
authors.lastname: Zhang
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D008517:Phytotherapy; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D002996:Clomiphene