Extracellular beta-glucuronidase for gene-directed enzyme-prodrug therapy.
Brüsselbach
Sabine
S
Institute of Molecular Biology and Tumour Research (IMT), Philipps-University Marburg, Marburg, Germany.
D001711:Biotransformation; D004317:Doxorubicin / Q000493:pharmacokinetics / Q000627:therapeutic use; D015316:Genetic Therapy / Q000379:methods*; D005966:Glucuronidase / Q000235:genetics*; D006801:Humans; D007202:Indicators and Reagents; D007700:Kinetics; D008247:Lysosomes / Q000201:enzymology; D016538:Mucopolysaccharidosis VII / Q000188:drug therapy / Q000235:genetics; D011355:Prodrugs / Q000493:pharmacokinetics* / Q000633:toxicity
D007202:Indicators and Reagents; D011355:Prodrugs; D004317:Doxorubicin; D005966:Glucuronidase