Synthetic developments towards PNA-peptide conjugates.
Since the discovery of peptide nucleic acids (PNAs) as DNA mimics in the early 1990s, a tremendous effort has been directed to their application as antisense and antigene probes. With the aim of further enhancing their properties, PNAs have been conjugated to a variety of effector molecules. Among these, small peptide fragments, often derived from functional proteins, are able to convey their specific properties to the conjugate.
de Koning
Martijn C
MC
Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300 RA Leiden, The Netherlands.
van der Marel
Gijs A
GA
Overhand
Mark
M
D008024:Ligands; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
D008024:Ligands; D020135:Peptide Nucleic Acids; D010455:Peptides