title: Genotypes of Pneumocystis jiroveci isolates obtained in Harare, Zimbabwe, and London, United Kingdom.
abstract: Isolates of Pneumocystis jiroveci from sulfa-exposed and nonexposed patients from London, United Kingdom, and Harare, Zimbabwe, were genotyped. At the dihydropteroate synthase (DHPS) locus, there was evidence of selection pressure from sulfa drug exposure, and reversal of DHPS genotype ratios occurred when selection pressure was absent or was removed.
authors.affiliation: Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London, London WC1E 6AU, United Kingdom. rmiller@gum.ucl.ac.uk
authors.forename: Robert F
authors.initials: RF
authors.lastname: Miller
authors.forename: Austin R
authors.initials: AR
authors.lastname: Lindley
authors.forename: Helen E
authors.initials: HE
authors.lastname: Ambrose
authors.forename: Adam S
authors.initials: AS
authors.lastname: Malin
authors.forename: Ann E
authors.initials: AE
authors.lastname: Wakefield
mesh_terms: D005838:Genotype; D015658:HIV Infections / Q000150:complications; D015497:HIV-1; D006801:Humans; D008131:London; D009181:Mycoses / Q000382:microbiology*; D011010:Pneumocystis / Q000235:genetics*; D016720:Pneumocystis Infections / Q000382:microbiology*; D012335:RNA, Ribosomal / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology; D006113:United Kingdom; D015030:Zimbabwe
chemical_list: D012335:RNA, Ribosomal; D012367:RNA, Viral; D015662:Trimethoprim, Sulfamethoxazole Drug Combination