title: SOLVE and RESOLVE: automated structure solution, density modification and model building.
abstract: The software SOLVE and RESOLVE can carry out all the steps in macromolecular structure solution, from scaling and heavy-atom location through phasing, density modification and model-building in the MAD, SAD and MIR cases. SOLVE uses scoring scheme to convert the decision-making in macromolecular structure solution to an optimization problem. RESOLVE carries out the identification of NCS, density modification and automated model-building. The procedure is fully automated and can function at resolutions as low as 3 A.
authors.affiliation: Los Alamos National Laboratory, USA. terwilliger@lanl.gov
authors.forename: Thomas
authors.initials: T
authors.lastname: Terwilliger
mesh_terms: D000465:Algorithms; D001665:Binding Sites; D003198:Computer Simulation; D003461:Crystallography / Q000379:methods*; D030562:Databases, Protein; D046911:Macromolecular Substances; D008958:Models, Molecular; D011485:Protein Binding; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D020539:Sequence Analysis, Protein; D012984:Software; D014584:User-Computer Interface
chemical_list: D046911:Macromolecular Substances; D011506:Proteins