New bromotyrosine derivatives from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis.
Three new bromotyrosine derivatives (4-6) were isolated from an association of two sponges, Jaspis wondoensis and Poecillastra wondoensis, along with the previously described (E,E)-psammaplin A (1), (E,Z)-psammaplin A (2), psammaplin D (3), bisaprasin (7), and (3-bromo-4-hydroxyphenyl)acetonitrile (8). The structures of the new compounds were established on the basis of NMR and MS spectroscopic analysis. The compounds 1, 3, and 5-7 displayed significant cytotoxicity against human lung (A549), ovarian (SK-OV-3), skin (SK-MEL-2), CNS (XF498), and colon (HCT15) cancer cell lines. Compounds 3-7 were further evaluated for antibacterial activity against methicillin- or ofloxacin-resistant Staphylococcus strains. Compound 4 exhibited more potent antibacterial activity than meropenem against several strains.
Park
Yujin
Y
College of Pharmacy, Pusan National University, Busan 609-735, Korea.
Liu
Yonghong
Y
Hong
Jongki
J
Lee
Chong-O
CO
Cho
Heeyeong
H
Kim
Dong-Kyoo
DK
Im
Kwang Sik
KS
Jung
Jee H
JH
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016543:Central Nervous System Neoplasms; D003110:Colonic Neoplasms; D004220:Disulfides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004578:Electron Spin Resonance Spectroscopy; D005260:Female; D006801:Humans; D007723:Korea; D008175:Lung Neoplasms; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology; D010051:Ovarian Neoplasms; D011161:Porifera / Q000737:chemistry*; D012878:Skin Neoplasms; D013210:Staphylococcus / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D004220:Disulfides; C475724:bromotyrosine; C098378:psammaplin A; D014443:Tyrosine; D015242:Ofloxacin