title: Cytotoxic effects of sesquiterpene lactones from the flowers of Hemisteptia lyrata B.
abstract: Four guaia-12,6-olide type sesquiterpene lactones, aguerin B (1), 8alpha-acetoxyzaluzanin C (2), cynaropicrin (3), and deacylcynaropicrin (4), were isolated from the flowers of Hemisteptia lyrata Bunge. It is the first report on the isolation of compounds 1-4 from Hemisteptia species. All the isolates (1-4) were examined for their cytotoxic activity against SK-OV-3, LOX-IMVI, A549, MCF-7, PC-3, and HCT-15 human cancer cell lines.
authors.affiliation: Institute of Agriculture and Life Science, Gyeongsang National University, Chinju 660-701, Korea.
authors.forename: Tae Joung
authors.initials: TJ
authors.lastname: Ha
authors.forename: Dae Sik
authors.initials: DS
authors.lastname: Jang
authors.forename: Jong Rok
authors.initials: JR
authors.lastname: Lee
authors.forename: Kyung Dong
authors.initials: KD
authors.lastname: Lee
authors.forename: Jun
authors.initials: J
authors.lastname: Lee
authors.forename: Seon Woo
authors.initials: SW
authors.lastname: Hwang
authors.forename: Hwa Jin
authors.initials: HJ
authors.lastname: Jung
authors.forename: Sang Hae
authors.initials: SH
authors.lastname: Nam
authors.forename: Ki Hun
authors.initials: KH
authors.lastname: Park
authors.forename: Min Suk
authors.initials: MS
authors.lastname: Yang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D019659:Asteraceae; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D035264:Flowers / Q000633:toxicity*; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*
chemical_list: D000970:Antineoplastic Agents; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes