title: Protein-losing gastroenteropathy and retinitis associated with cytomegalovirus infection in an immunocompetent infant: a case report.
abstract: A 6-week-old immunocompetent girl developed protein-losing gastroenteropathy (PLGE) and retinitis associated with cytomegalovirus (CMV) infection. At presentation, CMV antigenaemia (6 cells/46,000 white blood cells) and its DNA were detected in the patient's blood and in the mother's milk. Intravenous ganciclovir and gamma-globulin rapidly ameliorated all symptoms and CMV antigenaemia disappeared. No immunological defects were identified in this patient. To the best of our knowledge, this case involves the youngest known immunocompetent patient demonstrating CMV-induced PLGE and retinitis.
  
  
  CONCLUSIONS
  breast-feeding by a cytomegalovirus-positive mother can be a primary cause of early onset cytomegalovirus infection in infants.
authors.affiliation: Department of Paediatrics, Faculty of Medicine, Saga University, 5-1-1 Nabeshima, 849-8501 Saga, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Iwanaga
authors.forename: Masafumi
authors.initials: M
authors.lastname: Zaitsu
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ishii
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Shigeyasu
authors.initials: S
authors.lastname: Inada
authors.forename: Hiroka
authors.initials: H
authors.lastname: Yoshiki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Okinami
authors.forename: Yuhei
authors.initials: Y
authors.lastname: Hamasaki
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D001942:Breast Feeding / Q000009:adverse effects*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D015774:Ganciclovir / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008895:Milk, Human / Q000821:virology; D011504:Protein-Losing Enteropathies / Q000150:complications*; D012173:Retinitis / Q000150:complications*
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir