Flavonoids from Andrographis viscosula.
Phytochemical investigation of the whole plant of Andrographis viscosula has led to the isolation of three new 2'-oxygenated flavonoids, (2R)-5-hydroxy-7,2',3'-trimethoxyflavanone (1), 7,2',5'-trimethoxyflavone (2), 5,7,2',3'-tetramethoxyflavone (3), and eight known flavones, 5,7,2'-trimethoxyflavone (4), 5,7,2',4',5'-pentamethoxyflavone (5), echioidinin (6), 5,2',6'-trihydroxy-7-methoxyflavone (7), 5-hydroxy-7,2'-dimethoxyflavone (8), echioidin (9), echioidinin 5-O-glucoside (10), and 5,2',6'-trihydroxy-7-methoxyflavone 2'-O-glucoside (11). The structures of 1-11 were elucidated by physical and spectral methods, including extensive 2D NMR studies. The presence of 2'-oxygenated flavonoids is apparently restricted to Andrographis species in Acanthaceae. Therefore, 2'-oxygenated flavonoids are regarded as chemotaxonomic markers of Andrographis genus in the Acanthaceae family.
Rao
Yerra Koteswara
YK
Natural Products Division, Department of Chemistry, Sri Venkateswara University, Tirupati, India.
Damu
Amooru Gangaiah
AG
Rao
Alahari Janardhan
AJ
Venkatesan
Shanmuganathan
S
Kuo
Ping-Chung
PC
Rao
Chunduri Venkata
CV
Wu
Tian-Shung
TS
D035685:Andrographis; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D018514:Plant Structures
D005419:Flavonoids; D010936:Plant Extracts