Effect of fenoldopam on renal function after nephrotomy in normal dogs.
OBJECTIVE
To evaluate effects of fenoldopam on renal function in normal dogs subjected to bisection nephrotomy. In addition, effects of bisection nephrotomy on renal function in normal dogs were evaluated.


METHODS
Controlled, randomized, blinded experiment.


METHODS
Sixteen mixed-breed adult dogs.


METHODS
Dogs were paired for sex, body weight, and approximate age and assigned to 1 of 2 groups: fenoldopam (F) or placebo (P). Baseline glomerular filtration rate (GFR) based on quantitative renal scintigraphy using (99m)Tc-DTPA, blood urea nitrogen (BUN), serum creatinine (SCr), urinalysis, and urine culture were performed before surgery. Left nephrotomy was performed via median celiotomy. Group F dogs were administered intravenous (IV) fenoldopam (0.1 microg/kg/min) for 90 minutes, whereas group P dogs were administered an equivalent volume of saline (0.9 % NaCl) solution for 90 minutes. Temperature, heart rate, respiration, direct arterial blood pressure, and urine volume were recorded during anesthesia. Renal function was assessed by measuring SCr, BUN, and GFR at 1, 21, and 42 days after surgery.


RESULTS
There was no significant difference between groups in measured physiologic variables. No significant difference in GFR, BUN, or SCr between groups or between operated or control kidneys was detected.


CONCLUSIONS
Bisection nephrotomy in normal dogs with renal arterial occlusion of 15 minutes and using a simple continuous capsular closure does not adversely affect renal function.


CONCLUSIONS
Bisection nephrotomy, as described in this study, does not decrease renal function; perioperative administration of renoprotective agents is not necessary in normal dogs.
Zimmerman-Pope
Nancy
N
Department of Small Animal Clinical Sciences and Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0442, USA.
Waldron
Don R
DR
Barber
Don L
DL
Forrester
S Dru
SD
Wilcke
Jeff R
JR
Marini
Michele
M
D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004283:Dog Diseases / Q000188:drug therapy* / Q000601:surgery; D004285:Dogs; D005260:Female; D018818:Fenoldopam / Q000494:pharmacology* / Q000627:therapeutic use; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000662:veterinary; D007668:Kidney / Q000187:drug effects* / Q000502:physiology / Q000601:surgery; D007674:Kidney Diseases / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D007677:Kidney Function Tests / Q000662:veterinary; D007684:Kidney Tubules / Q000187:drug effects; D008297:Male; D012079:Renal Circulation / Q000187:drug effects; D016284:Technetium Tc 99m Pentetate; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use
D014665:Vasodilator Agents; D003404:Creatinine; D018818:Fenoldopam; D016284:Technetium Tc 99m Pentetate