title: Syringolymphoid hyperplasia with alopecia: two case reports and review of the literature.
abstract: Syringolymphoid hyperplasia with alopecia is an uncommon, but histopathologically distinct, skin disorder that has been reported to occur with and possibly represent a syringotropic variant of cutaneous T-cell lymphoma. We report 2 patients with syringolymphoid hyperplasia with alopecia. Both had CD4-positive infiltrates; 1 also demonstrated loss of CD7. One patient had evidence of T-cell clonality by gene rearrangement studies, but neither had histologic evidence of cutaneous T-cell lymphoma. Because the natural progression of syringolymphoid hyperplasia with alopecia remains to be fully explained, close follow-up of patients is advised.
authors.affiliation: Department of Dermatology, Henry Ford Hospital, 2799 West Grand Boulevard, Detroit, MI 48202, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Hobbs
authors.forename: Marsha L
authors.initials: ML
authors.lastname: Chaffins
authors.forename: Margaret C
authors.initials: MC
authors.lastname: Douglass
mesh_terms: D000328:Adult; D000505:Alopecia / Q000150:complications*; D006801:Humans; D006965:Hyperplasia; D008221:Lymphoid Tissue / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology; D008297:Male; D012871:Skin Diseases / Q000473:pathology*