The nature and identification of quantitative trait loci: a community's view.
This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?
Abiola
Oduola
O
Angel
Joe M
JM
Avner
Philip
P
Bachmanov
Alexander A
AA
Belknap
John K
JK
Bennett
Beth
B
Blankenhorn
Elizabeth P
EP
Blizard
David A
DA
Bolivar
Valerie
V
Brockmann
Gundrun A
GA
Buck
Kari J
KJ
Bureau
Jean-Francoise
JF
Casley
William L
WL
Chesler
Elissa J
EJ
Cheverud
James M
JM
Churchill
Gary A
GA
Cook
Melloni
M
Crabbe
John C
JC
Crusio
Wim E
WE
Darvasi
Ariel
A
de Haan
Gerald
G
Dermant
Peter
P
Doerge
R W
RW
Elliot
Rosemary W
RW
Farber
Charles R
CR
Flaherty
Lorraine
L
Flint
Jonathan
J
Gershenfeld
Howard
H
Gibson
John P
JP
Gu
Jing
J
Gu
Weikuan
W
Himmelbauer
Heinz
H
Hitzemann
Robert
R
Hsu
Hui-Chen
HC
Hunter
Kent
K
Iraqi
Fuad F
FF
Jansen
Ritsert C
RC
Johnson
Thomas E
TE
Jones
Byron C
BC
Kempermann
Gerd
G
Lammert
Frank
F
Lu
Lu
L
Manly
Kenneth F
KF
Matthews
Douglas B
DB
Medrano
Juan F
JF
Mehrabian
Margarete
M
Mittlemann
Guy
G
Mock
Beverly A
BA
Mogil
Jeffrey S
JS
Montagutelli
Xavier
X
Morahan
Grant
G
Mountz
John D
JD
Nagase
Hiroki
H
Nowakowski
Richard S
RS
O'Hara
Bruce F
BF
Osadchuk
Alexander V
AV
Paigen
Beverly
B
Palmer
Abraham A
AA
Peirce
Jeremy L
JL
Pomp
Daniel
D
Rosemann
Michael
M
Rosen
Glenn D
GD
Schalkwyk
Leonard C
LC
Seltzer
Ze'ev
Z
Settle
Stephen
S
Shimomura
Kazuhiro
K
Shou
Siming
S
Sikela
James M
JM
Siracusa
Linda D
LD
Spearow
Jimmy L
JL
Teuscher
Cory
C
Threadgill
David W
DW
Toth
Linda A
LA
Toye
Ayo A
AA
Vadasz
Csaba
C
Van Zant
Gary
G
Wakeland
Edward
E
Williams
Robert W
RW
Zhang
Huang-Ge
HG
Zou
Fei
F
D000818:Animals; D030801:Animals, Genetically Modified; D002874:Chromosome Mapping / Q000592:standards*; D006801:Humans; D040641:Quantitative Trait Loci