Experimental evaluation of antifungal and antiseptic agents against Rhodotorula spp.
We studied the susceptibility of 21 strains of Rhodotorula rubra and nine strains of R. glutinis to eight antifungals and tested eight antiseptic agents on one strain of R. rubra. The tested strains were susceptible to ketoconazole, 5-fluorocytosine, amphotericin B, and nystatin, intermediate to econazole and resistant to fluconazole, itraconazole and miconazole. After 5-min contact, six of the eight antiseptic agents tested showed a fungicidal activity on the tested R. rubra strain.
Preney
L
L
Laboratoire de Parasitologie-Mycologie, Centre Hospitalier Universitaire, Rennes, France. jean-pierre.gangneux@chu-rennes.fr
Théraud
M
M
Guiguen
C
C
Gangneux
J P
JP
D000666:Amphotericin B / Q000494:pharmacology; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D025141:Drug Resistance, Fungal; D004464:Econazole / Q000494:pharmacology; D015725:Fluconazole / Q000494:pharmacology; D005437:Flucytosine / Q000494:pharmacology; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D007654:Ketoconazole / Q000494:pharmacology; D008825:Miconazole; D008826:Microbial Sensitivity Tests / Q000379:methods; D009761:Nystatin / Q000494:pharmacology; D012248:Rhodotorula / Q000187:drug effects*
D000891:Anti-Infective Agents, Local; D000935:Antifungal Agents; D009761:Nystatin; D017964:Itraconazole; D004464:Econazole; D008825:Miconazole; D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine; D007654:Ketoconazole