title: Inhibitory activities of aromatic amino acid esters and peptides against ovalbumin permeation through Caco-2 cell monolayers.
abstract: Trp, Phe, and Tyr ethyl esters and their dipeptides with Gly at the C-terminals inhibited ovalbumin (OVA) permeation through Caco-2 monolayers. The inhibitory activity of Trp ethyl ester was the highest at near the concentration of 10(-6) M. It was suggested that Trp ethyl ester inhibited transcellular permeation of OVA.
authors.affiliation: Department of Food and Life-science, Takasaki University of Health and Welfare, Japan. teshoko@takasaki-u.ac.jp
authors.forename: Shoko
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Jun
authors.initials: J
authors.lastname: Watanabe
mesh_terms: D000230:Adenocarcinoma; D024322:Amino Acids, Aromatic / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms; D004952:Esters; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D010047:Ovalbumin / Q000187:drug effects / Q000493:pharmacokinetics*; D010455:Peptides / Q000494:pharmacology*
chemical_list: D024322:Amino Acids, Aromatic; D004952:Esters; D010455:Peptides; D010047:Ovalbumin