Placental malaria and perinatal transmission of human immunodeficiency virus type 1.
Prevalence of placental malaria in human immunodeficiency virus (HIV) type 1-infected and -uninfected women and the effect of placental malaria on genital shedding and perinatal transmission of HIV-1 were examined. Genital samples for HIV-1 DNA RNA were collected during labor. Infants were tested for HIV-1 at 1 day and 6 weeks postpartum. Placental malaria was diagnosed by histopathological examination: 372 placentas of HIV-1-infected women and 277 of HIV-1-uninfected women were processed. A higher prevalence of placental malaria was seen in HIV-1-infected women. No association was found between placental malaria and either maternal virus load, genital HIV-1 DNA, or HIV-1 RNA. Placental malaria did not correlate with in utero or peripartal transmission of HIV-1.
Inion
Ingrid
I
International Centre for Reproductive Health, Ghent University, Ghent, Belgium.
Mwanyumba
Fabian
F
Gaillard
Philippe
P
Chohan
Varsha
V
Verhofstede
Chris
C
Claeys
Patricia
P
Mandaliya
Kishorchandra
K
Van Marck
Eric
E
Temmerman
Marleen
M
D000163:Acquired Immunodeficiency Syndrome / Q000635:transmission*; D000328:Adult; D005260:Female; D015497:HIV-1; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008288:Malaria / Q000821:virology*; D010922:Placenta Diseases / Q000821:virology*; D011247:Pregnancy; D019562:Viral Load