title: Physicochemical and crystallographic characterization of mefenamic acid complexes with alkanolamines.
abstract: The preparation of mefenamic acid (MH)-alkanolamine (propanolamine, diethanolamine, triethanolamine) complexes was attempted to increase the transdermal flux of MH. Differential scanning calorimetry, Fourier transform infrared spectroscopy, and X-ray crystallographic studies demonstrated that MH and each alkanolamine formed an ion pair complex. The series of amine complexes had a lower melting point and higher solubility in water compared with pure MH.
authors.affiliation: Faculty of Pharmaceutial Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan.
authors.forename: Liang
authors.initials: L
authors.lastname: Fang
authors.forename: Sachihiko
authors.initials: S
authors.lastname: Numajiri
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kobayashi
authors.forename: Hideo
authors.initials: H
authors.lastname: Ueda
authors.forename: Koji
authors.initials: K
authors.lastname: Nakayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miyamae
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Morimoto
mesh_terms: D000473:Alkanes / Q000032:analysis / Q000737:chemistry*; D000588:Amines / Q000032:analysis / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D018360:Crystallography, X-Ray / Q000379:methods; D046911:Macromolecular Substances; D008528:Mefenamic Acid / Q000032:analysis / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods
chemical_list: D000473:Alkanes; D000588:Amines; D046911:Macromolecular Substances; D008528:Mefenamic Acid