[Gene expression of MMP1 and TIMP1 in lung cancer detected with a cDNA microarray technique].
OBJECTIVE
To investigate the gene expression of matrix metalloproteinases 1 (MMP1) and tissue inhibitors of matrix metalloprotainases 1(TIMP1) in squmas cell lung cancer and adenocarcinoma.


METHODS
Gene expression profile cDNA microarray egntaining 4,096 genes was used to identify differentially expressed genes in squmas cell lung cancer and adenocarcinoma, and to analyze the gene expression of MMP1 and TIMP1.


RESULTS
Gene MMP1 and TIMP1 were differentially expressed in both squmas cell lung cancer and adenocarcinoma, and both of them were up-regulated.


CONCLUSIONS
MMP1 and TIMP1 may be important molecular markers of squmas cell lung cancer and adenocarcinoma.
Ouyang
Qu-chang
QC
Department of Respiration, Xiangya Hospital, Central South University, Changsha 410008, China.
Hu
Cheng-ping
CP
Liang
Qing-hua
QH
D000230:Adenocarcinoma / Q000201:enzymology / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000235:genetics*; D020781:Matrix Metalloproteinase 1 / Q000235:genetics* / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000235:genetics* / Q000378:metabolism
D019715:Tissue Inhibitor of Metalloproteinase-1; D020781:Matrix Metalloproteinase 1