Tissue factor expression and prognosis in patients with metastatic prostate cancer.
OBJECTIVE
To assess immunohistochemically the pattern of tissue factor (TF) expression in patients with metastatic prostate cancer, because TF is aberrantly expressed in human cancer. TF is the primary initiator of the coagulation cascade.


METHODS
Seventy-three patients with untreated metastatic prostate cancer who received hormonal therapy were included in the present study. Biopsy specimens were stained with anti-human TF antibody. We evaluated the histologic grade, extent of bony metastasis, clinical response to hormonal therapy, and patient prognosis.


RESULTS
TF was detected in 75.3% of the tumors of the patients with metastatic prostate cancer. TF expression showed no association with histologic grade, extent of bony metastasis, or clinical response to hormonal therapy. Patients with TF-positive tumors had a poorer cause-specific survival than those with TF-negative tumors. Multivariate analysis showed that TF expression, clinical response to hormonal therapy, and extent of bony metastasis were significant prognostic factors.


CONCLUSIONS
The TF content measured using immunohistochemical staining was a useful prognostic factor for patients with metastatic prostate cancer treated with androgen withdrawal therapy.
Akashi
Takuya
T
Department of Urology, Toyama Medical and Pharmaceutical University Faculty of Medicine, Sugitani, Toyama, Japan.
Furuya
Yuzo
Y
Ohta
Shoichiro
S
Fuse
Hideki
H
D000230:Adenocarcinoma / Q000188:drug therapy / Q000378:metabolism / Q000401:mortality / Q000556:secondary*; D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000401:mortality / Q000556:secondary*; D002715:Chlormadinone Acetate / Q000627:therapeutic use; D004054:Diethylstilbestrol / Q000627:therapeutic use; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D009919:Orchiectomy; D011379:Prognosis; D016016:Proportional Hazards Models; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000401:mortality; D016019:Survival Analysis; D013925:Thromboplastin / Q000096:biosynthesis* / Q000235:genetics
D018931:Antineoplastic Agents, Hormonal; D009363:Neoplasm Proteins; D002715:Chlormadinone Acetate; D004054:Diethylstilbestrol; D013925:Thromboplastin