title: Palladium-catalyzed regioselective arylation of imidazo[1,2-a]pyrimidine.
abstract: Imidazo[1,2-a]pyrimidine can be arylated at the 3-position with aryl bromides in the presence of base and a catalytic amount of palladium. This provides an efficient one-step synthesis of 3-arylimidazo[1,2-a]pyrimidines from the unsubstituted heterocycle. [reaction: see text]
authors.affiliation: Process Research Department, Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA. wenjie_li@merck.com
authors.forename: Wenjie
authors.initials: W
authors.lastname: Li
authors.forename: Dorian P
authors.initials: DP
authors.lastname: Nelson
authors.forename: Mark S
authors.initials: MS
authors.lastname: Jensen
authors.forename: R Scott
authors.initials: RS
authors.lastname: Hoerrner
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Javadi
authors.forename: Dongwei
authors.initials: D
authors.lastname: Cai
authors.forename: Robert D
authors.initials: RD
authors.lastname: Larsen