Synthesis and biological evaluation of ebselen and its acyclic derivatives.
Five ebselen and three acyclic ebselen derivatives were synthesized. These compounds were screened for their glutathione peroxidase (GSH Px)-like activity and scavenging activity against 1,1-diphenyl-2-pycryl-hydrazyl (DPPH) and peroxynitrite radical. All tested compounds displayed similar significant GSH Px-like activity, which are slightly higher than that of ebselen. The peroxynitrite scavenging activity showed that the acyclic allylseleno 4c was five times more potent than ebselen.
Chang
Tsu-Chung
TC
Department of Biochemistry, National Defense Medical Center, Neihu, Taipei, Taiwan, ROC.
Huang
Mei-Lan
ML
Hsu
Wen-Lin
WL
Hwang
Jing-Min
JM
Hsu
Ling-Yih
LY
D001393:Azoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology; D006839:Hydrocarbons, Acyclic / Q000138:chemical synthesis / Q000494:pharmacology; D054833:Isoindoles; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*
D001393:Azoles; D016166:Free Radical Scavengers; D006839:Hydrocarbons, Acyclic; D054833:Isoindoles; D016566:Organoselenium Compounds; C042986:ebselen