AMH signaling: from receptor to target gene.
Anti-Müllerian hormone (AMH), also known as Müllerian inhibiting substance (MIS), is a member of the transforming growth factor beta (TGFbeta) superfamily and plays a crucial role during male sexual differentiation. Although the AMH type II receptor has been identified, the identity of the other signaling components has remained unknown. This review describes the identification of candidate AMH type I receptors and an AMH-target gene involved in Müllerian duct regression.
Visser
Jenny A
JA
Department of Internal Medicine, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands. j.visser@erasmusmc.nl
D030201:Activin Receptors, Type I / Q000235:genetics / Q000502:physiology; D000818:Animals; D054304:Anti-Mullerian Hormone; D052005:Bone Morphogenetic Protein Receptors, Type I; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics / Q000502:physiology; D008954:Models, Biological; D009095:Mullerian Ducts / Q000196:embryology / Q000502:physiology; D010750:Phosphoproteins / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000502:physiology; D017978:Receptors, Growth Factor / Q000235:genetics / Q000502:physiology; D018000:Receptors, Peptide / Q000502:physiology*; D018125:Receptors, Transforming Growth Factor beta; D012733:Sex Differentiation / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D051785:Smad Proteins; D051902:Smad5 Protein; D051904:Smad8 Protein; D013735:Testicular Hormones / Q000502:physiology*; D015534:Trans-Activators / Q000235:genetics
D004268:DNA-Binding Proteins; D006023:Glycoproteins; D010750:Phosphoproteins; D017978:Receptors, Growth Factor; D018000:Receptors, Peptide; D018125:Receptors, Transforming Growth Factor beta; C497797:SMAD5 protein, human; C107514:SMAD9 protein, human; D051785:Smad Proteins; D051902:Smad5 Protein; D051904:Smad8 Protein; D013735:Testicular Hormones; D015534:Trans-Activators; C084621:anti-Mullerian hormone receptor; D054304:Anti-Mullerian Hormone; D017346:Protein Serine-Threonine Kinases; D030201:Activin Receptors, Type I; D052005:Bone Morphogenetic Protein Receptors, Type I; D020778:Matrix Metalloproteinase 2