title: Intestinal metaplasia: evolution after Helicobacter pylori eradication and influence in the success of eradicating therapy.
abstract: BACKGROUND
  intestinal metaplasia associated with Helicobacter pylori infection is a stage of the temporal sequence of histological lesions gradually induced by this microorganism. It is considered a preneoplastic lesion and its regression after eradication is controversial.
  
  
  OBJECTIVE
  to assess the evolution of intestinal metaplasia after eradication and to investigate whether metaplasia is a factor that contributes to successful treatment.
  
  
  METHODS
  four hundred Helicobacter pylori positive patients were studied. Eradicating therapy was administered and endoscopic biopsies of gastric antrum and body were taken before and after eradication. Among other histological data, the presence of intestinal metaplasia was assessed.
  
  
  RESULTS
  of all patients successfully treated, biopsies were taken before and after eradication in 268 of them: 71 (26,5%) had metaplasia before and 50 (18,7%) after eradication. A significant difference was observed in the outcome (p = 0,036) of the first eradicating treatment between the group without initial metaplasia (72,7%) and the group with initial metaplasia (61.2%).
  
  
  CONCLUSIONS
  Helicobacter pylori eradication can revert intestinal metaplasia in some patients. On the other hand, the first treatment could be less successful in patients with intestinal metaplasia.
authors.affiliation: Servicio de Gastroenterología y Hepatología. Hospital Ramón y Cajal. Madrid. Spain.
authors.forename: M
authors.initials: M
authors.lastname: Vázquez Romero
authors.forename: D
authors.initials: D
authors.lastname: Boixeda de Miquel
authors.forename: M P
authors.initials: MP
authors.lastname: Valer López-Fando
authors.forename: E
authors.initials: E
authors.lastname: Albéniz Arbizu
authors.forename: R
authors.initials: R
authors.lastname: González Alonso
authors.forename: F
authors.initials: F
authors.lastname: Bermejo San José
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D007422:Intestines / Q000473:pathology*; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D011446:Prospective Studies