title: The structure of a sulfated galactan from Porphyra haitanensis and its in vivo antioxidant activity.
abstract: The sulfated galactan fraction F1 isolated from the red seaweed, Porphyra haitanensis, showed typical porphyran structure. It has a linear backbone of alternating 3-linked beta-D-galactosyl units and 4-linked alpha-L-galactosyl 6-sulfate and 3,6-anhydro-alpha-L-galactosyl units. The L-residues are mainly composed of alpha-L-galactosyl 6-sulfate units, and the 3,6-anhydrogalactosyl units are minor. Partial methylation occurred at the C-6 position of the D-galactosyl units and at the C-2 position of the 3,6-anhydro-alpha-L-galactosyl units. Intraperitoneal administration of F1 significantly decreased the lipid peroxidation in aging mice. F1 treatment increased the total antioxidant capacity and the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in aging mice. The results indicated that F1 had significant in vivo antioxidant activity.
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China. qb-zhang@ms.qdio.ac.cn
authors.forename: Quanbin
authors.initials: Q
authors.lastname: Zhang
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Xiguang
authors.initials: X
authors.lastname: Liu
authors.forename: Zengqin
authors.initials: Z
authors.lastname: Zhao
authors.forename: Zhien
authors.initials: Z
authors.lastname: Li
authors.forename: Zuhong
authors.initials: Z
authors.lastname: Xu
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D001921:Brain / Q000378:metabolism; D005685:Galactans / Q000737:chemistry* / Q000494:pharmacology; D005690:Galactose / Q000737:chemistry; D005979:Glutathione Peroxidase / Q000378:metabolism; D006321:Heart / Q000502:physiology; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D051379:Mice; D044664:Porphyra / Q000737:chemistry*; D012624:Seaweed / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005685:Galactans; C046510:galactan polysulfate; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005690:Galactose