Long-term genetic effects of radiation exposure.
To date, there has been little experimental knowledge on the genetic risks of human exposure to ionising radiation for humans. Recent data suggest that hypervariable tandem repeat minisatellite loci provide a useful and sensitive experimental approach for monitoring radiation-induced germline mutation in humans. Here, I review the results of studies on minisatellite mutation rates in human populations exposed to radioactive fallout after the Chernobyl accident and nuclear weapon tests in Kazakhstan.
Dubrova
Yuri E
YE
Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK. yed2@le.ac.uk
D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods; D005260:Female; D030342:Genetic Diseases, Inborn / Q000000981:diagnostic imaging; D006801:Humans; D018598:Minisatellite Repeats / Q000528:radiation effects*; D011247:Pregnancy; D011839:Radiation, Ionizing; D018788:Radioactive Hazard Release / Q000145:classification; D011877:Radionuclide Imaging