title: [Blood lactate levels during fast-track cardiac anesthesia].
abstract: BACKGROUND
  Lactate is a very sensitive marker of outcomes in critically ill patients. The aim of this study was to investigate the significance of blood lactate measurement during fast-track cardiac anesthesia.
  
  
  METHODS
  We examined arterial blood lactate levels of 12 patients following coronary artery bypass graft surgery under intermittent aortic cross clamping with fast-track cardiac anesthesia. Anesthesia was induced with propofol and fentanyl, and maintained with propofol, fentanyl (total 400-1000 micrograms) and isoflurane. Blood samples were collected from a radical artery catheter.
  
  
  RESULTS
  At the termination of the extracorporeal circulation, the blood lactate was 10.3 +/- 2.0 (7.4-12.5) mmol.l-1. This value decreased slowly to 1.5 +/- 0.4 mmol.l-1 on the second postoperative day. All patients were extubated within 4 hours after surgery. Vital signs were stable, and no cardiac events occurred perioperatively.
  
  
  CONCLUSIONS
  A continuous decline in blood lactate levels was related to a favorable postoperative course. Further research might be required to prevent transient hyperlactecemia at the end of cardiopulmonary bypass.
authors.affiliation: Department of Anesthesiology, Saitama Medical Center, Saitama Medical School, Kawagoe 350-8550.
authors.forename: Kaoru
authors.initials: K
authors.lastname: Koyama
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Okuyama
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Fukuyama
authors.forename: Yumi
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Jun
authors.initials: J
authors.lastname: Kawasaki
authors.forename: Hideki
authors.initials: H
authors.lastname: Miyao
mesh_terms: D000368:Aged; D000768:Anesthesia, General / Q000009:adverse effects* / Q000379:methods; D015415:Biomarkers / Q000097:blood; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D001026:Coronary Artery Bypass; D005260:Female; D006439:Hemodynamics; D006801:Humans; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D011379:Prognosis; D013997:Time Factors
chemical_list: D015415:Biomarkers; D019344:Lactic Acid