title: Insulin resistance and maximal oxygen uptake.
abstract: BACKGROUND
  Type 2 diabetes, coronary atherosclerosis, and physical fitness all correlate with insulin resistance, but the relative importance of each component is unknown.
  
  
  OBJECTIVE
  This study was undertaken to determine the relationship between insulin resistance, maximal oxygen uptake, and the presence of either diabetes or ischemic heart disease.
  
  
  METHODS
  The study population comprised 33 patients with and without diabetes and ischemic heart disease. Insulin resistance was measured by a hyperinsulinemic euglycemic clamp; maximal oxygen uptake was measured during a bicycle exercise test.
  
  
  RESULTS
  There was a strong correlation between maximal oxygen uptake and insulin-stimulated glucose uptake (r = 0.7, p = 0.001), and maximal oxygen uptake was the only factor of importance for determining insulin sensitivity in a model, which also included the presence of diabetes and ischemic heart disease.
  
  
  CONCLUSIONS
  Maximal oxygen uptake may be a more important determinant for insulin sensitivity than ischemic heart disease and type 2 diabetes.
authors.affiliation: Gentofte University Hospital, Denmark. ms@heart.dk
authors.forename: Marie
authors.initials: M
authors.lastname: Seibaek
authors.forename: Henrik
authors.initials: H
authors.lastname: Vestergaard
authors.forename: Hans
authors.initials: H
authors.lastname: Burchardt
authors.forename: Carsten
authors.initials: C
authors.lastname: Sloth
authors.forename: Christian
authors.initials: C
authors.lastname: Torp-Pedersen
authors.forename: Steen Levin
authors.initials: SL
authors.lastname: Nielsen
authors.forename: Per
authors.initials: P
authors.lastname: Hildebrandt
authors.forename: Oluf
authors.initials: O
authors.lastname: Pedersen
mesh_terms: D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000378:metabolism / Q000503:physiopathology*; D015444:Exercise / Q000502:physiology; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism; D009203:Myocardial Infarction / Q000378:metabolism / Q000503:physiopathology*; D010100:Oxygen / Q000378:metabolism*; D010809:Physical Fitness; D011446:Prospective Studies
chemical_list: D010100:Oxygen