title: Application of genome-wide expression analysis to identify molecular markers useful in monitoring industrial fermentations.
abstract: Genome-wide expression analysis of an industrial strain of Saccharomyces cerevisiae identified the YOR387c and YGL258w homologues as highly inducible in zinc-depleted conditions. Induction was specific for zinc deficiency and was dependent on Zap1p. The results indicate that these sequences may be valuable molecular markers for detecting zinc deficiency in industrial fermentations.
authors.affiliation: Clive and Vera Ramaciotti Centre for Gene Function Analysis, University of New South Wales, Sydney, New South Wales 2052, Australia. v.higgins@unsw.edu.au
authors.forename: Vincent J
authors.initials: VJ
authors.lastname: Higgins
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Rogers
authors.forename: Ian W
authors.initials: IW
authors.lastname: Dawes
mesh_terms: D003470:Culture Media; D005285:Fermentation; D020869:Gene Expression Profiling; D015966:Gene Expression Regulation, Fungal; D005819:Genetic Markers; D016681:Genome, Fungal; D007218:Industrial Microbiology / Q000379:methods; D020411:Oligonucleotide Array Sequence Analysis; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism*; D015032:Zinc / Q000378:metabolism
chemical_list: D003470:Culture Media; D005819:Genetic Markers; D029701:Saccharomyces cerevisiae Proteins; D015032:Zinc