Sudden presentation of immune-mediated inner ear disease: characterization and acceptance of a cochleovestibular dysfunction.
Since the McCabe report, growing indirect evidence has accumulated to indicate the implication of immune mechanisms in the pathogenesis of immune-mediated inner-ear disease (IMIED). A clinical study of a group of patients affected by this condition was performed in order to characterize the immune group, based on a recently reported profile, and compared with the vascular, viral and idiopathic aetiologies of sudden deafness. Patients affected by immune-mediated inner-ear disease had the best and the earliest recovery rate of hearing (p = 0.0028 and p = 0.017, respectively). However, this group of patients also had the higher rate of recurrence (p = 0.034), supporting the typical clinical course of the autoimmune disorders. On the basis of the results the criteria used in the diagnosis of the sudden presentation of the immune-mediated inner ear disease could be accepted leading to the characterization of this condition. Likewise, the role of the supporting cells in the pathogenesis of the IMIED is discussed.
García-Berrocal
José Ramón
JR
Service of Otorhinolaryngology, Clinica Puerta de Hierro Hospital, Department of Surgery, Faculty of Medicine, Autónoma University, Madrid, Spain. jrgarciab@yahoo.com
Ramírez-Camacho
Rafael
R
Millán
Isabel
I
Górriz
Carmen
C
Trinidad
Almudena
A
Arellano
Beatriz
B
Lobo
David
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D007758:Ear, Inner / Q000276:immunology / Q000503:physiopathology / Q000648:ultrastructure; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D003639:Hearing Loss, Sudden / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D011379:Prognosis; D012008:Recurrence; D016896:Treatment Outcome; D014652:Vascular Diseases / Q000150:complications; D014777:Virus Diseases / Q000150:complications
D005938:Glucocorticoids; D011239:Prednisolone