Doses to fetal and maternal organs from intravenous 59FeCl3 or 57CoCl2.
Doses from intravenous intakes of 59Fe or 57Co chloride during pregnancy were estimated. Near term fetal organ doses were derived via the MIRDOSE3 newborn phantom, with mean dose/cumulated activity (S) values rescaled for compatibility with near term fetus whole body S. A detailed in vivo biodistribution database provided indications of residence times in important maternal and fetal organs. 59Fe doses to the fetus whole body from early to late pregnancy were 7-11 mGy MBq(-1) (8.5-14.3 mSv MBq(-1)), similar to that to the mother. Doses to near term fetal spleen (59 mGy MBq(-1)), liver (36), and red marrow (9) were similar or higher than to the mother. 57Co doses to fetus whole body from early to late pregnancy were 0.7-3.3 mGy MBq(-1) (2.5-8.2 mSv MBq(-1)), similar or higher than to the mother. Doses to near term fetal small intestine (34 mGy MBq(-1)). liver (4.7) and red marrow (2.7) were similar or higher than to the mother.
Saunders
M
M
Medical Physics, Division of Oncology, University of Bristol, UK.
Palmer
A M
AM
Millard
R K
RK
Preece
A W
AW
D001822:Body Burden; D003037:Cobalt Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003198:Computer Simulation; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D007504:Iron Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D009928:Organ Specificity; D011247:Pregnancy; D011264:Pregnancy Trimesters / Q000502:physiology; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D012062:Relative Biological Effectiveness; D018570:Risk Assessment / Q000379:methods*
D003037:Cobalt Radioisotopes; D007504:Iron Radioisotopes