title: Heparanase, galectin-3, and tissue factor mRNA are expressed in benign neoplasms of the thyroid.
abstract: OBJECTIVE
  Heparanase, galectin-3, and tissue factor (TF) are overexpressed in solid malignant thyroid tumors. We studied their expression in multinodular goiters (MNGs).
  
  
  METHODS
  Thyroid tissue specimens from 15 MNGs were obtained during surgery. mRNA expression for galectin-3, heparanase, and TF was assessed by RT-PCR.
  
  
  RESULTS
  Isolated expressions of heparanase and galectin- 3 mRNA were expressed in 2 and 4 of the 15 MNGs, respectively; 8/15 MNGs were positive for both heparanase and galectin-3. TF mRNA was found in all MNG specimens.
  
  
  CONCLUSIONS
  Galectin-3, heparanase, and TF RNA expression is prevalent in MNGs. Further studies will be needed to determine the prognostic significance of these findings.
authors.affiliation: Diabetes Unit and Internal Medicine "C", Assaf Harofeh Medical Center, Zerifin 70300, Israel. abuchs@netvision.net.il
authors.forename: Andreas E
authors.initials: AE
authors.lastname: Buchs
authors.forename: Sergei
authors.initials: S
authors.lastname: Zehavi
authors.forename: Osnat
authors.initials: O
authors.lastname: Sher
authors.forename: Eyal
authors.initials: E
authors.lastname: Yeheskely
authors.forename: Michael
authors.initials: M
authors.lastname: Muggia-Sulam
authors.forename: Yoav
authors.initials: Y
authors.lastname: Sherman
authors.forename: Micha J
authors.initials: MJ
authors.lastname: Rapoport
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D005260:Female; D037502:Galectin 3 / Q000032:analysis* / Q000235:genetics; D005966:Glucuronidase / Q000032:analysis* / Q000235:genetics; D006044:Goiter, Nodular / Q000378:metabolism*; D006801:Humans; D008297:Male; D012333:RNA, Messenger / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013925:Thromboplastin / Q000032:analysis* / Q000235:genetics; D013964:Thyroid Neoplasms / Q000737:chemistry; D000099175:Heparanase
chemical_list: D014408:Biomarkers, Tumor; D037502:Galectin 3; D005966:Glucuronidase; D012333:RNA, Messenger; D013925:Thromboplastin; D000099175:Heparanase