Lack of association between TrkA single nucleotide polymorphisms and sporadic Alzheimer's disease in a Japanese population.
Nerve growth factor and its receptor with tyrosine kinase activity (TrkA) have been implicated in the development of Alzheimer's disease (AD). Entire coding regions of TrkA gene harboring exons 1 through 17 were sequenced in 114 patients with sporadic AD and 112 control subjects in a Japanese population, and six known and two novel single nucleotide polymorphisms were identified, but no mutation associated with sporadic AD was identified. Concurrently, case-control analysis of TrkA gene A1674G polymorphism in 534 patients with sporadic AD and 454 control subjects has revealed no significant differences in TrkA genotype or allele frequencies even after stratification for Apolipoprotein E epsilon4 carrier statuses. Thus, the TrkA genotype does not appear to influence the risk of developing sporadic AD in a Japanese population.
Sakasegawa
Yuji
Y
Department of Cortical Function Disorders, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan.
Kishida
Hitaru
H
Sakurai
Michiko
M
Asada
Takashi
T
Kinoshita
Toru
T
Goto
Yuichi
Y
Kimura
Hideo
H
Kuroiwa
Yoshiyuki
Y
Hachiya
Naomi S
NS
Kaneko
Kiyotoshi
K
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005091:Exons; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D020917:Receptor, trkA; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
D002352:Carrier Proteins; D008565:Membrane Proteins; D020917:Receptor, trkA