title: [Genetic engineering potential and perspectives in the management of critical ischemia].
abstract: The paper presents a new approach to management of lower limb critical ischemia which implements recent advances in molecular biology and genetic engineering technologies. A new original compound incorporating angiogenin gene was developed to activate neoangiogenesis processes after injection into living tissues. Experimental data evidence a potential efficacy of new method for complex management of critical ischemia.
authors.affiliation: Department of Vascular Surgery, Russian Research Center of Surgery, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: B A
authors.initials: BA
authors.lastname: Konstantinov
authors.forename: N P
authors.initials: NP
authors.lastname: Bochkov
authors.forename: A V
authors.initials: AV
authors.lastname: Gavrilenko
authors.forename: D A
authors.initials: DA
authors.lastname: Voronov
authors.forename: V Z
authors.initials: VZ
authors.lastname: Tarantul
authors.forename: G F
authors.initials: GF
authors.lastname: Sheremet'eva
authors.forename: S I
authors.initials: SI
authors.lastname: Skrylev
authors.forename: N V
authors.initials: NV
authors.lastname: Khaĭdarova
mesh_terms: D000818:Animals; D002642:Chick Embryo; D002908:Chronic Disease; D004274:DNA, Recombinant / Q000235:genetics; D005822:Genetic Vectors / Q000235:genetics; D007511:Ischemia / Q000235:genetics* / Q000601:surgery / Q000628:therapy*; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D018919:Neovascularization, Physiologic / Q000502:physiology; D010957:Plasmids / Q000235:genetics; D015202:Protein Engineering / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D012259:Ribonuclease, Pancreatic / Q000235:genetics* / Q000627:therapeutic use*; D014656:Vascular Surgical Procedures / Q000379:methods
chemical_list: D004274:DNA, Recombinant; C046366:angiogenin; D012259:Ribonuclease, Pancreatic