title: Stereotactic MR imaging for planning neural transplantation: a reliable technique at 3 Tesla?
abstract: The purpose of this study was to assess the accuracy of high field (3 Tesla) MR in target localization for stem cell transplantation. Three patients with Huntington's disease were imaged with a stereotactic frame in place for both MRI and CT. Quality assurance procedures and manual shimming were performed before each MRI study to minimize image distortion. The images were fused using multi-modality rigid body image registration software. Image fusion demonstrated the MR images to be in agreement with CT to within 1.5 mm, as assessed by measuring the coordinates of markers on the frame and on the shape and size of the lateral ventricles. Target coordinates for transplantation were selected from the MR images. Postoperative imaging confirmed accurate graft placement.
authors.affiliation: Wolfson Brain Imaging Centre, University of Cambridge, UK. t.donovan@ulsm.ac.uk
authors.forename: T
authors.initials: T
authors.lastname: Donovan
authors.forename: T D
authors.initials: TD
authors.lastname: Fryer
authors.forename: A
authors.initials: A
authors.lastname: Peña
authors.forename: C
authors.initials: C
authors.lastname: Watts
authors.forename: T A
authors.initials: TA
authors.lastname: Carpenter
authors.forename: J D
authors.initials: JD
authors.lastname: Pickard
mesh_terms: D016380:Brain Tissue Transplantation / Q000379:methods / Q000592:standards; D003342:Corpus Striatum / Q000637:transplantation*; D006801:Humans; D006816:Huntington Disease / Q000601:surgery*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015203:Reproducibility of Results; D013234:Stem Cells; D013238:Stereotaxic Techniques; D014057:Tomography, X-Ray Computed / Q000379:methods