title: Persistent atrial fibrillation: a population based study of patients with their first cardioversion.
abstract: BACKGROUND
  Electrical cardioversion is effective in terminating even long standing atrial fibrillation (AF), but the relapse risk of AF is high. Data on long-term success of cardioversion in real life clinical practice are scant.
  
  
  METHODS
  Restoration and maintenance of sinus rhythm as well as acceptance of permanent AF was studied in a population based cohort (catchment area with a population of 440,000) of patients with persistent AF after first elective cardioversion.
  
  
  RESULTS
  Of the 183 patients having their first electrical cardioversion during the 1-year study period, sinus rhythm was restored in 153 patients (84%). Only 39 of these (25%) maintained sinus rhythm for 1 year, even though 108 (71%) patients had anti-arrhythmic medication. Age, hypertension, coronary artery disease, heart failure and valvular disease, or absence of these known risk factors for AF were not associated with the outcome. The outcome was better if the cardioversion was performed earlier than the median delay (78 days) from the diagnosis of AF to cardioversion compared to longer delay (P=0.022 in multivariate modelling). The decision of acceptance of permanent AF was made in 74 cases (40%) during 1 year of follow-up.
  
  
  CONCLUSIONS
  Patients with persistent AF had a high tendency to remain in or relapse into AF, even though most patients had anti-arrhythmic medication after first cardioversion. Short history of arrhythmia was associated with better outcome. Acceptance of permanent AF was made in almost half of the cases during 1 year of follow-up.
authors.affiliation: Department of Medicine, Maria Hospital, Helsinki University Hospital, 00290 Helsinki, Finland. mika.lehto@fimnet.fi
authors.forename: Mika
authors.initials: M
authors.lastname: Lehto
authors.forename: Risto
authors.initials: R
authors.lastname: Kala
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000453:epidemiology / Q000628:therapy*; D015331:Cohort Studies; D004554:Electric Countershock; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016016:Proportional Hazards Models; D012008:Recurrence; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents