title: For investigational targeted drugs, combination trials pose challenges.
authors.forename: Bruce
authors.initials: B
authors.lastname: Goldman
mesh_terms: D000911:Antibodies, Monoclonal / Q000494:pharmacology; D061067:Antibodies, Monoclonal, Humanized; D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D000068258:Bevacizumab; D001943:Breast Neoplasms / Q000188:drug therapy; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy; D002986:Clinical Trials as Topic; D017321:Clinical Trials, Phase I as Topic; D017322:Clinical Trials, Phase II as Topic; D004345:Drug Industry / Q000592:standards*; D015507:Drugs, Investigational / Q000494:pharmacology*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D000069347:Erlotinib Hydrochloride; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D016393:Lymphoma, B-Cell / Q000188:drug therapy; D009101:Multiple Myeloma / Q000188:drug therapy; D009316:National Institutes of Health (U.S.); D011799:Quinazolines / Q000494:pharmacology; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000187:drug effects; D000069283:Rituximab; D013792:Thalidomide / Q000494:pharmacology; D000068878:Trastuzumab; D014481:United States
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D058846:Antibodies, Monoclonal, Murine-Derived; D000068258:Bevacizumab; D015507:Drugs, Investigational; D066246:ErbB Receptors; D000069347:Erlotinib Hydrochloride; D011799:Quinazolines; D018719:Erb-b2 Receptor Tyrosine Kinases; D000069283:Rituximab; D013792:Thalidomide; D000068878:Trastuzumab