title: Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats.
abstract: 3,4-Methylenedioxymethamphetamine (MDMA, "Ecstasy") is a drug frequently used under hot conditions in nightclubs. In rats tested in the social interaction paradigm, greater prosocial effects of MDMA (5.0 mg/kg) were seen at a hot temperature (30 degrees C) relative to normal laboratory temperature (21 degrees C). In the intravenous drug self-administration paradigm, hot temperature (30 degrees C) increased the number of MDMA infusions (0.1, 0.3 or 1.0 mg/kg/infusion) self-administered by rats. Hot temperatures thus appear to affect both the social and reinforcing effects of MDMA.
authors.affiliation: School of Psychology, University of Sydney, A19 NSW 2006, Australia.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Cornish
authors.forename: Zeeshan
authors.initials: Z
authors.lastname: Shahnawaz
authors.forename: Murray R
authors.initials: MR
authors.lastname: Thompson
authors.forename: Suzanna
authors.initials: S
authors.lastname: Wong
authors.forename: Kirsten C
authors.initials: KC
authors.lastname: Morley
authors.forename: Glenn E
authors.initials: GE
authors.lastname: Hunt
authors.forename: Iain S
authors.initials: IS
authors.lastname: McGregor
mesh_terms: D000818:Animals; D006358:Hot Temperature; D007398:Interpersonal Relations; D008297:Male; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012646:Self Administration
chemical_list: D018817:N-Methyl-3,4-methylenedioxyamphetamine