Genetic testing for hemochromatosis: attitudes and acceptability among young and older adults.
Hemochromatosis is a genetic disorder of iron overload common in persons of northern European descent. We examined attitudes about testing for hemochromatosis in 118 young adults (YA) (19.7 years +/- 1.9) and 50 older adults (OA) (58.5 years +/- 13.7). Participants read about hemochromatosis and two related tests: transferrin saturation measurement (iron test) and HFE genotyping (HFE test). Interest in each test and attitudes about genetic testing were assessed. More than 80% of all participants were willing to undergo either test, if offered. A majority preferred the iron test because of the information it provides about current health. A majority of participants identified at least one benefit of genetic testing, with improved health through early detection/prevention being most common. YA were more likely to report disadvantages of genetic testing (p < 0.001) and were more concerned about potential negative psychological effects (p < 0.005). OA were more concerned about potential discrimination (p < 0.0001). These findings suggest that young and older adults view genetic testing as beneficial and would accept HFE testing were it offered as part of a screening program.
Hicken
Bret L
BL
Department of Psychology, University of Alabama at Birmingham, 1530 Third Avenue South, Birmingham, AL 35294-1170, USA.
Calhoun
David C
DC
Tucker
Diane C
DC
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001294:Attitude to Health; D005260:Female; D005820:Genetic Testing; D007722:Health Knowledge, Attitudes, Practice; D006432:Hemochromatosis / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014168:Transferrin / Q000032:analysis
D014168:Transferrin