title: Toluene exposure increases aminophylline-induced seizure susceptibility in mice.
abstract: The effects of toluene on the sensitivity to seizures induced by aminophylline were investigated. Mice were pretreated with an ip injection of corn oil or toluene (100-500 mg/kg) followed by a timed intravenous infusion of aminophylline at various time intervals to assess the seizure thresholds and lethal doses. Toluene increased seizure susceptibility to aminophylline in a dose- and time-dependent manner. Toluene-induced enhancement of seizure susceptibility to aminophylline occurred as early as 30 min and persisted for at least 3 days after a single administration of toluene (500 mg/kg). Treatment of benzaldehyde, one of toluene's metabolites, also showed an increase in the susceptibility to aminophylline. The enhancing effect was also observed in caffeine-induced seizures 1 h, but not 1 day after toluene treatment. These results suggest that individuals with toluene exposure may increase the risk for convulsive and even lethal complications associated with the therapeutic use of aminophylline.
authors.affiliation: Department of Pharmacology, Tzu Chi University, Hualien, Taiwan.
authors.forename: Ming-Huan
authors.initials: MH
authors.lastname: Chan
authors.forename: Hwei-Hsien
authors.initials: HH
authors.lastname: Chen
mesh_terms: D000628:Aminophylline / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001547:Benzaldehydes / Q000008:administration & dosage / Q000633:toxicity; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology; D004195:Disease Models, Animal; D004357:Drug Synergism; D007262:Infusions, Intravenous; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D012997:Solvents / Q000008:administration & dosage / Q000633:toxicity*; D014050:Toluene / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D001547:Benzaldehydes; D001993:Bronchodilator Agents; D012997:Solvents; D000628:Aminophylline; D014050:Toluene; D002110:Caffeine; C032175:benzaldehyde