title: Pallial origin of mitral cells in the olfactory bulbs of Xenopus.
abstract: We used two developmental transcription factors, x-Eomes (T-box family) and x-Lhx5 (LIM-homeodomain family), to follow the origin and development of the olfactory bulbs in Xenopus. During embryonic and larval development, x-Eomes and x-Lhx5 were expressed in highly similar patterns, in the lateral and latero-ventral wall of the pallium. In adults, both markers were strongly and specifically expressed in mitral cells, i.e., in the projection neurons of the main and accessory olfactory bulbs. These results demonstrate the pallial origin of the olfactory projecting cells in Xenopus. Combined with previous results suggesting a subpallial origin for olfactory interneurons, these findings emphasize the dual origin of different neuronal populations in the bulbs of anamniotes, and suggest that this organization is a shared feature of tetrapods.
authors.affiliation: Departmento de Biología Celular, Facultad de Biología, Universidad Complutense, Madrid, Spain.
authors.forename: Nerea
authors.initials: N
authors.lastname: Moreno
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bachy
authors.forename: Sylvie
authors.initials: S
authors.lastname: Rétaux
authors.forename: Agustín
authors.initials: A
authors.lastname: González
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology* / Q000254:growth & development*; D007814:Larva; D009434:Neural Pathways / Q000166:cytology / Q000254:growth & development; D009830:Olfactory Bulb / Q000166:cytology* / Q000254:growth & development*; D013687:Telencephalon / Q000166:cytology / Q000254:growth & development; D014982:Xenopus laevis