title: Decompressive craniectomy in severe brain injury.
abstract: OBJECTIVE
  The goal of this study was to evaluate the therapeutic role of decompressive craniectomy in severe brain injury.
  
  
  RESULTS
  Between 1996 and 1998 we treated 87 patients with severe brain injury (GCS 3-8) in our department. In 70 cases follow up data could be obtained. Mean age was 49 years (range 1-79). Initial CT scans of all patients demonstrated diffuse brain injury with generalised brain swelling and/or mass lesion. In 51 of these patients uni (n=40)- or bilateral (n=11) decompressive craniectomy was performed initially or secondarily after failure of standard treatment. In a retrospective analysis we performed statistical tests of the follow-up group. The mortality rate did not show a significant difference between the two treatment groups (p=0.802) with a slight advantage for the decompression. The log-rank-test demonstrated a non-significant improvement of the survival time for decompressed patients (p=0.632). Secondary decompression showed a significantly better survival rate and time compared to primary decompression. In all 7 pediatric cases (1-16 yrs) we performed craniectomy. 2 of them died immediately post emergency operation, 5 survived with good outcome (1 LOF).
  
  
  CONCLUSIONS
  A slight, but non-significant benefit could be demonstrated after decompressive craniectomy in the whole patient population. In young patients decompression seems to have a more positive influence on outcome and survival.
authors.affiliation: Neurosurgical Clinic, University Hospital, Heinrich-Heine-University, Düsseldorf, Germany. Messing-Juenger@med.uni-duesseldorf.de
authors.forename: A M
authors.initials: AM
authors.lastname: Messing-Jünger
authors.forename: J
authors.initials: J
authors.lastname: Marzog
authors.forename: G
authors.initials: G
authors.lastname: Wöbker
authors.forename: M
authors.initials: M
authors.lastname: Sabel
authors.forename: W J
authors.initials: WJ
authors.lastname: Bock
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001929:Brain Edema / Q000601:surgery; D001930:Brain Injuries / Q000401:mortality / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003399:Craniotomy; D019299:Decompression, Surgical; D005260:Female; D005500:Follow-Up Studies; D015600:Glasgow Coma Scale; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D012189:Retrospective Studies; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed