[SMC (structural maintenance of chromosomes) structural protein family and their role in chromatin reorganization].
Structural chromatin proteins of the SMC (Structural Maintenance of Chromosomes) family play an important role in structural DNA reorganization in pro- and eukaryotes. Eukaryotic SMC proteins are the core components of the cohesin and condensin complexes. The cohesin complex is responsible for sister chromatid and homolog cohesion in mitosis and meiosis. The condensin complex uses ATP energy to induce positive coiled-coils in DNA, which results in compaction of the latter and formation of mitotic chromosome scaffold. In addition, the SMC proteins constitute recombination and recombination repair complexes. In hermaphrodites of nematode Caenorhabditis elegans, the SMC protein-containing complex controls dosage compensation and inactivation of the X chromosome genes.
Pavlova
S V
SV
Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, 630090 Russia.
Zakiian
S M
SM
D000255:Adenosine Triphosphate / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000502:physiology*; D002843:Chromatin / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D019281:Dimerization; D006868:Hydrolysis; D008540:Meiosis; D008938:Mitosis; D009695:Nucleic Acid Renaturation; D011487:Protein Conformation; D012854:Sister Chromatid Exchange
D018797:Cell Cycle Proteins; D002843:Chromatin; C438001:Smc1l2 protein, mouse; D000255:Adenosine Triphosphate; D004247:DNA