title: Improvement of generalised dystonia by olanzapine treatment.
abstract: This is the first report on generalised dystonia beneficially treated by olanzapine. A 63-year-old Taiwanese man with intractable general dystonia was treated with olanzapine starting at a dose of 2.5 mg/day to the maximal dose of 15 mg/day. Clinically, there was slow, but steady, improvement in his dystonia and disability after olanzapine treatment. Evaluation of his dystonia 3 months later revealed 70% improvement on dystonic movement and 60% on disability on the Burke-Fahn-Marsden Dystonia Scale. The result suggests that treatment with olanzapine can be an alternative therapy for patients with generalised dystonia.
authors.affiliation: Department of Neurology, Chushang Show-Chwan Hospital, ROC, Nantou, Taiwan. jjlinn@tcts.seed.net.tw
authors.forename: Juei Jueng
authors.initials: JJ
authors.lastname: Lin
authors.forename: Dar Cheng
authors.initials: DC
authors.lastname: Chang
mesh_terms: D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D004185:Disability Evaluation; D004421:Dystonia / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D012720:Severity of Illness Index
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine