title: [Management of the acute respiratory distress syndrome].
abstract: OBJECTIVE
  To review the current support and treatment strategies of the acute respiratory distress syndrome.
  
  
  METHODS
  Original data from our research laboratory and from representative scientific articles on acute respiratory distress syndrome and acute lung Injury searched through Medline.
  
  
  RESULTS
  Despite advances in the understanding of the pathogenesis of acute respiratory distress syndrome, this syndrome still results in significant morbidity and mortality. Mechanical ventilation, the main therapeutic modality for acute respiratory distress syndrome, is no longer considered simply a support modality, but a therapy capable of influencing the course of the disease. New ventilation strategies, such as high-frequency oscillatory ventilation appear to be promising. This text reviews the current knowledge of acute respiratory distress syndrome management, including conventional and non-conventional ventilation, the use of surfactant, nitric oxide, modulators of inflammation, extracorporeal membrane oxygenation and prone position.
  
  
  CONCLUSIONS
  The last decade was marked by significant advances, such as the concept of protective ventilation for acute respiratory distress syndrome. The benefit of alternative strategies, such as high-frequency oscillatory ventilation, the use of surfactant and immunomodulators continue to be the target of study.
authors.affiliation: State University of New York at Buffallo, NY 14222, USA. arotta@buffalo.edu
authors.forename: Alexandre Tellechea
authors.initials: AT
authors.lastname: Rotta
authors.forename: Cláudia Laura Barberio
authors.initials: CL
authors.lastname: Kunrath
authors.forename: Budi
authors.initials: B
authors.lastname: Wiryawan
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D015199:Extracorporeal Membrane Oxygenation; D006612:High-Frequency Ventilation; D006801:Humans; D009569:Nitric Oxide / Q000627:therapeutic use; D016684:Prone Position; D011663:Pulmonary Surfactants / Q000627:therapeutic use; D012121:Respiration, Artificial / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000628:therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D011663:Pulmonary Surfactants; D009569:Nitric Oxide