title: Bactericidal effect of cethromycin (ABT-773) in an immunocompetent murine pneumococcal pneumonia model.
abstract: The efficacy of cethromycin was assessed against isolates of Streptococcus pneumoniae in the presence of neutrophils. Comparison with data from our previous neutropenic model revealed that the presence of neutrophils enhanced the bacteriostatic and bactericidal effect of cethromycin by an average of two- to four-times, respectively.
authors.affiliation: Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, PO Box 5037, Hartford, CT 06102-5037, USA.
authors.forename: Blair
authors.initials: B
authors.lastname: Capitano
authors.forename: Dana
authors.initials: D
authors.lastname: Maglio
authors.forename: Mary Anne
authors.initials: MA
authors.lastname: Banevicius
authors.forename: Charles H
authors.initials: CH
authors.lastname: Nightingale
authors.forename: David P
authors.initials: DP
authors.lastname: Nicolau
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D004917:Erythromycin / Q000031:analogs & derivatives / Q000494:pharmacology*; D005260:Female; D007121:Immunocompetence; D048628:Ketolides; D051379:Mice; D008808:Mice, Inbred CBA; D009503:Neutropenia / Q000276:immunology / Q000382:microbiology; D009504:Neutrophils / Q000276:immunology; D011018:Pneumonia, Pneumococcal / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D004917:Erythromycin; C405499:cethromycin