title: Acid-etched microtexture for enhancement of bone growth into porous-coated implants.
abstract: We designed an in vivo study to determine if the superimposition of a microtexture on the surface of sintered titanium beads affected the extent of bone ingrowth. Cylindrical titanium intramedullary implants were coated with titanium beads to form a porous finish using commercial sintering techniques. A control group of implants was left in the as-sintered condition. The test group was etched in a boiling acidic solution to create an irregular surface over the entire porous coating. Six experimental dogs underwent simultaneous bilateral femoral intramedullary implantation of a control implant and an acid etched implant. At 12 weeks, the implants were harvested in situ and the femora processed for undecalcified, histological examination. Eight transverse serial sections for each implant were analysed by backscattered electron microscopy and the extent of bone ingrowth was quantified by computer-aided image analysis. The extent of bone ingrowth into the control implants was 15.8% while the extent of bone ingrowth into the etched implants was 25.3%, a difference of 60% that was statistically significant. These results are consistent with other research that documents the positive effect of microtextured surfaces on bone formation at an implant surface. The acid etching process developed for this study represents a simple method for enhancing the potential of commonly available porous coatings for biological fixation.
authors.affiliation: Division of Orthopaedics, McGill University, Montreal, Quebec, Canada.
authors.forename: S A
authors.initials: SA
authors.lastname: Hacking
authors.forename: E J
authors.initials: EJ
authors.lastname: Harvey
authors.forename: M
authors.initials: M
authors.lastname: Tanzer
authors.forename: J J
authors.initials: JJ
authors.lastname: Krygier
authors.forename: J D
authors.initials: JD
authors.lastname: Bobyn
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible; D004285:Dogs; D005269:Femur; D006851:Hydrochloric Acid; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007595:Joint Prosthesis; D008422:Materials Testing / Q000379:methods; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D011474:Prosthesis Design; D013499:Surface Properties; D014025:Titanium
chemical_list: D020099:Coated Materials, Biocompatible; D014025:Titanium; D006851:Hydrochloric Acid