title: Genetics and functional genomics of type 2 diabetes mellitus.
abstract: Genome-wide studies of transcription in the skeletal muscle of type 2 diabetic patients have identified coordinated changes in the expression of genes involved in oxidative phosphorylation, and have underlined the central role of the oxidative-phosphorylation regulator, PCG1alpha. These findings help unravel the complex pathogenesis and inheritance of polygenic type 2 diabetes mellitus.
authors.affiliation: The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
authors.forename: Ayo
authors.initials: A
authors.lastname: Toye
authors.forename: Dominique
authors.initials: D
authors.lastname: Gauguier
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D023281:Genomics / Q000379:methods*; D006801:Humans; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology; D010085:Oxidative Phosphorylation; D014158:Transcription, Genetic