Avascular necrosis of the femoral head in a HIV-1 infected patient receiving lopinavir/ritonavir.
The wide use of protease inhibitors (PI) as part of a highly active antiretroviral (HAART) regimen is associated with the development of several side effects. Among these, the development of avascular necrosis (AVN) of the bone is being reported more frequently and it has been related both to the use of PI and to HIV-1 infection itself. We report here a case of AVN of the bone in a patient taking the new PI lopinavir (LPV)/ritonavir (RTV) as part of a HAART regimen.
Bongiovanni
Marco
M
Institute of Infectious Diseases and Tropical Medicine, Luigi Sacco Hospital, University of Milan, Via G.B. Grassi 74, 20157 Milan, Italy. marco.bongiovanni@unimi.it
Chiesa
Elisabetta
E
Riva
Agostino
A
d'Arminio Monforte
Antonella
A
Bini
Teresa
T
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D005271:Femur Head Necrosis / Q000209:etiology*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D015497:HIV-1; D006801:Humans; D061466:Lopinavir; D008297:Male; D011744:Pyrimidinones / Q000009:adverse effects*; D019438:Ritonavir / Q000009:adverse effects*
D011744:Pyrimidinones; D061466:Lopinavir; D019438:Ritonavir