[Association of herpes simplex virus type2 infection with dyslipidemia in Chinese].
OBJECTIVE
To investigate the relationship between herpes simplex virus type 2 (HSV-2) infection and dyslipidemia.


METHODS
ELISA was used to detect the specific IgG to HSV-2 in the samples of peripheral blood collected in succession from 1 244 inpatients, 408 with dyslipidemia and 836 controls without dyslipidemia. Univariate and multivariate analyses were preformed.


RESULTS
No significant differences were found in sex and smoking status between the patients with and without dyslipidemia (both P > 0.05). However, the body mass index was significantly higher in the patients with dyslipidemia than in those without dyslipidemia (24.9 +/- 6.6 vs 23.9 +/- 7.6, P = 0.001). Diabetes and hypertension were more frequently found in patients with dyslipidemia in comparison with those without dyslipidemia (both P < 0.05). The prevalence of HSV-2 IgG seropositivity was significantly higher in the patients with dyslipidemia than those without dyslipidemia (38.2% vs 30.6%, P = 0.007). Binary Logistic regression analysis showed an association of HSV-2 IgG seropositivity with dyslipidemia, after adjustment for confoundings, the odds ratio for dyslipidemia was 1.34 (95% confidence interval, 1.04 to 1.72; P = 0.025) for HSV-2 IgG seropositivity. Other traditional risk factors, body mass index [adjusted OR 1.03 (1.01 - 1.05), P = 0.002], hypertension [adjusted OR 1.39 (1.09 - 1.79), P = 0.008] and diabetes [adjusted OR 1.50 (1.05 - 2.15), P = 0.028].


CONCLUSIONS
HSV-2 infection is an independent risk factor for dyslipidemia, and HSV-2 infection may increase the risk of dyslipidemia.
Sun
Yu-hua
YH
Sino-German Laboratory, Cardiovascular Institute & Fuwai Heart Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing 100037, China.
Pei
Wei-dong
WD
Wu
Yong-jian
YJ
Wang
Guo-gan
GG
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D006561:Herpes Simplex / Q000150:complications*; D018258:Herpesvirus 2, Human; D006801:Humans; D006949:Hyperlipidemias / Q000209:etiology*; D007074:Immunoglobulin G / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D000914:Antibodies, Viral; D007074:Immunoglobulin G