title: Relationships between S-100 protein-positive cells and clinicopathological factors in patients with colorectal cancer.
abstract: BACKGROUND
  An increased number of dendritic cells (DCs), as indicated by positive S-100 protein staining, has been shown to correlate with good prognosis in several malignancies. The clinicopathological significance of S-100 protein-positive cells in human colorectal cancer is unclear and was thus examined.
  
  
  METHODS
  We investigated the relationships between the density of S-100 protein-positive cells at the peripheral area of the tumor, prognosis and clinicopathological factors in 30 patients with colorectal cancer. S-100 protein-positive cells were detected by immunohistochemistry using a mouse monoclonal antibody against S-100 protein.
  
  
  RESULTS
  The number of S-100 protein-positive cells was significantly higher in patients with a good prognosis or those without recurrence or worsening of their condition, but was significantly lower in patients with lymph node metastasis, T3-T4, hepatic metastasis or tumors more advanced than stage III (TNM).
  
  
  CONCLUSIONS
  S-100 protein-positive cells may act as one line of defense against malignant cells in patients with colorectal cancer.
authors.affiliation: Department of Surgery 1, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi-ku, Kita-kyushu 807-8555, Japan.
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Inoue
authors.forename: Noritaka
authors.initials: N
authors.lastname: Minagawa
authors.forename: Takefumi
authors.initials: T
authors.lastname: Katsuki
authors.forename: Nobuo
authors.initials: N
authors.lastname: Nagashima
authors.forename: Koji
authors.initials: K
authors.lastname: Onitsuka
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Tsurudome
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Sako
authors.forename: Keiji
authors.initials: K
authors.lastname: Hirata
authors.forename: Naoki
authors.initials: N
authors.lastname: Nagata
authors.forename: Hideaki
authors.initials: H
authors.lastname: Itoh
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000276:immunology / Q000378:metabolism*
chemical_list: D009418:S100 Proteins