title: Effects of illicit drug use on adherence to prescribed antiretroviral medication.
abstract: This exploratory analysis compared adherence to antiretroviral medication on days that illicit drugs were used and on matched abstinence days in twelve subjects who used MEMS caps during participation in a clinical trial. Adherence on drug use days was lower in seven subjects, higher in one, and the same in four. Three subjects maintained 100% adherence despite illicit substance use on studied days. Thus, in a subset of patients, the actions involved in procuring drugs and the acute effects of using them contribute to non-adherence on those specific drug use days, associated with substance abuse. (Am J Addict 2003;12:455-458)
authors.affiliation: Department of Psychiatry, VA Connecticut Healthcare System, West Haven, CT 06516, USA. marc.rosen@yale.edu
authors.forename: Marc I
authors.initials: MI
authors.lastname: Rosen
authors.forename: Michael O
authors.initials: MO
authors.lastname: Rigsby
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Dieckhaus
authors.forename: Joyce A
authors.initials: JA
authors.lastname: Cramer
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D015897:Comorbidity; D003376:Counseling; D005246:Feedback; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000523:psychology; D006801:Humans; D013287:Illicit Drugs; D008297:Male; D019966:Substance-Related Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000523:psychology; D014040:Token Economy; D016896:Treatment Outcome; D016312:Treatment Refusal / Q000523:psychology / Q000706:statistics & numerical data*
chemical_list: D019380:Anti-HIV Agents; D013287:Illicit Drugs