Paget's disease.
A review of the signs, symptoms, and treatment of Paget's disease is presented. Paget, or osteitis deformans, is a chronic, progressive, bone disease of viral etiology. Recent investigations about the causative agent of this disorder have implicated the measles virus of the paramyxovirus family. Additional studies have demonstrated that abnormal virus-infected osteoclasts generate interleukin (IL)-6, a resorptive cytokine from the bone marrow of patients with Paget's bone disease.
Bender
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Department of Dental Medicine, Albert Einstein Medical Center, Philadelphia, PA, USA.
D006801:Humans; D007571:Jaw Diseases / Q000175:diagnosis* / Q000188:drug therapy; D010001:Osteitis Deformans / Q000175:diagnosis* / Q000188:drug therapy; D014076:Tooth Diseases / Q000175:diagnosis* / Q000188:drug therapy