Regulation of myocardial triacylglycerol synthesis and metabolism.
Studies showing a correlation of excess myocardial triacylglycerol stores with apoptosis, fibrosis, and contractile dysfunction indicate that dysregulation of triacylglycerol metabolism may contribute to cardiac disease. This review covers the regulation of heart triacylglycerol accumulation at the critical control points of fatty acid uptake, enzymes of triacylglycerol synthesis, lipolysis, and lipoprotein secretion. These pathways are discussed in the context of the central role myocardial triacylglycerol plays in cardiac energy metabolism and heart disease.
Lewin
Tal M
TM
Department of Nutrition, School of Public Health, University of North Carolina, CB #7400, Pittsboro Street, Chapel Hill, NC 27599, USA.
Coleman
Rosalind A
RA
D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D008066:Lipolysis; D008074:Lipoproteins / Q000096:biosynthesis / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D014280:Triglycerides / Q000096:biosynthesis* / Q000378:metabolism*
D005227:Fatty Acids; D008074:Lipoproteins; D014280:Triglycerides