title: Sunpollenol and five other rearranged 3,4-seco-tirucallane-type triterpenoids from sunflower pollen and their inhibitory effects on Epstein-Barr virus activation.
abstract: Six new rearranged 3,4-seco-tirucallane-type triterpenoids (1-6) have been isolated from the diethyl ether extract of the pollen grains of sunflower (Helianthus annuus). These compounds were evaluated with respect to their inhibitory effects on the induction of Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. All of the compounds tested showed potent inhibitory effects on EBV-EA activation (97-100% inhibition at 1 x 10(3) mol ratio/TPA).
authors.affiliation: College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan.
authors.forename: Motohiko
authors.initials: M
authors.lastname: Ukiya
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Akihisa
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Kazuo
authors.initials: K
authors.lastname: Koike
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kimura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Asano
authors.forename: Shigeyasu
authors.initials: S
authors.lastname: Motohashi
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Nikaido
authors.forename: Hoyoku
authors.initials: H
authors.lastname: Nishino
mesh_terms: D000956:Antigens, Viral / Q000187:drug effects; D006368:Helianthus / Q000737:chemistry*; D006801:Humans; D007564:Japan; D016393:Lymphoma, B-Cell; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D011058:Pollen / Q000737:chemistry*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014775:Virus Activation
chemical_list: D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D014315:Triterpenes; C482482:sunpollenol; D013755:Tetradecanoylphorbol Acetate