[The study on the effects of the oil from Hippophae rhamnoides in hematopoiesis].
OBJECTIVE
To investigate the possibility of the oil from Hippophae rhamnoides (OHR) in supporting the hematopoitic reconstitution after high dose chemotherapy.


METHODS
The mice were fed with OHR and variation of blood cell counts of the mice was recorded. Animal models of myelosuppression were built by 5-Fu intra-peritoneal infusion. The effects of OHR in the hematopoietic reconstitution were observed.


RESULTS
The counts of erythrocytes of OHR group were significantly elevated. The blood cell counts in myelosuppression mice fed with OHR exceeded those in control group, and the mortality was decreased.


CONCLUSIONS
OHR can improve the hematopoiesis of erythroid linage. Like G-CSF, OHR can stimulate the recovery of hematopoiesis after chemotherapy.
Chen
Yunxian
Y
First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080.
Zhong
Xueyun
X
Liu
Tianhao
T
Ge
Zhihong
Z
D000818:Animals; D001772:Blood Cell Count; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D004906:Erythrocyte Count; D005260:Female; D005472:Fluorouracil; D006410:Hematopoiesis / Q000187:drug effects*; D031281:Hippophae / Q000737:chemistry; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D016513:Mice, SCID; D010938:Plant Oils / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D016511:Severe Combined Immunodeficiency / Q000097:blood* / Q000139:chemically induced
D004365:Drugs, Chinese Herbal; D010938:Plant Oils; D005472:Fluorouracil