title: The Ki67 index a prognostic marker in medullary thyroid carcinoma.
abstract: Our objective was to examine the usefulness of the Ki67 proliferation index as a prognostic marker in patients with medullary thyroid carcinoma (MTC). It is difficult to predict the prognosis of MTC by using conventional prognostic factors. Immunocytochemical analysis of tumour proliferation has been used as a prognostic tool in some tumours, but only rarely in MTC. In all, 71 tumours from 36 patients were investigated, by using a semiautomatic image analysis programme. On average 10,000 nuclear profiles were counted per tumour, and the percentage of tumour cells expressing the proliferation marker, Ki67, was calculated. Primary tumours that had metastasised had higher Ki67 indices than primary tumours that had not metastasised. Recurrent lymph node metastasis had higher Ki67 indices than the primary tumours. By using a Poisson model, it was possible to estimate the median survival time for individual patients if the Ki67 index for the primary tumour and the age at surgery were known. The higher the Ki67 index and the age at operation were, the shorter was the survival. Estimating the median survival of individual patients will be of help for planning the patients' life and postoperative follow-up and treatment.
authors.affiliation: The Lundberg Laboratory for Cancer Research, Department of Surgery, Göteborg University Hospital, Göteborg University, Gothenburg, Sweden. larstisell@hotmail.com
authors.forename: L E
authors.initials: LE
authors.lastname: Tisell
authors.forename: A
authors.initials: A
authors.lastname: Oden
authors.forename: A
authors.initials: A
authors.lastname: Muth
authors.forename: G
authors.initials: G
authors.lastname: Altiparmak
authors.forename: J
authors.initials: J
authors.lastname: Mõlne
authors.forename: H
authors.initials: H
authors.lastname: Ahlman
authors.forename: O
authors.initials: O
authors.lastname: Nilsson
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D018276:Carcinoma, Medullary / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis*; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013964:Thyroid Neoplasms / Q000175:diagnosis*; D013965:Thyroidectomy; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D016159:Tumor Suppressor Protein p53