title: Lateral approach to the sciatic nerve in the popliteal fossa: a comparison between 1.5% mepivacaine and 0.75% ropivacaine.
abstract: OBJECTIVE
  Ropivacaine and mepivacaine are commonly used local anesthetics for peripheral nerve blockade. The purpose of the present study was to compare onset time, quality of anesthesia, and duration of analgesia with ropivacaine 0.75% and mepivacaine 1.5% for lateral popliteal nerve block.
  
  
  METHODS
  Fifty American Society of Anesthesiologists (ASA) physical status I or II patients scheduled for foot and ankle surgery with calf tourniquet under lateral popliteal sciatic nerve block were randomly assigned to receive 30 mL of either ropivacaine 0.75% or mepivacaine 1.5%. Time required for onset of sensory and motor block, resolution of motor blockade, onset of postsurgical pain, and time of first analgesic medication were recorded.
  
  
  RESULTS
  The 2 groups were similar with regard to demographic variables and duration of surgery. Onset of sensory and motor block was significantly shorter in the mepivacaine group (9.9 +/- 3.3 min and 14.7 +/- 3.6 min, respectively) than in the ropivacaine group (18.1 +/- 6.1 min and 23.6 +/- 5.5 min, respectively) (P < 0.001). Resolution of motor block occurred later in the ropivacaine group than in the mepivacaine group (P < 0.001), and duration of postoperative analgesia was significantly longer in the ropivacaine group (19 +/- 3.4 h) compared with the mepivacaine group (5.9 +/- 1.1 h) (P < 0.001). Analgesic requirements were higher in mepivacaine group than in the ropivacaine group (P < 0.001). There were 2 failed blocks, one in each group.
  
  
  CONCLUSIONS
  Both ropivacaine and mepivacaine provided effective sciatic nerve blockade. Mepivacaine 1.5% displayed a significantly shorter onset time than ropivacaine 0.75%. Postoperatively, ropivacaine 0.75% resulted in longer-lasting analgesia and less need for oral pain medication.
authors.affiliation: Department of Anesthesiology, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain. manutabo@mixmail.com
authors.forename: Manuel
authors.initials: M
authors.lastname: Taboada
authors.forename: Joaquín
authors.initials: J
authors.lastname: Cortés
authors.forename: Jaime
authors.initials: J
authors.lastname: Rodríguez
authors.forename: Beatriz
authors.initials: B
authors.lastname: Ulloa
authors.forename: Julián
authors.initials: J
authors.lastname: Alvarez
authors.forename: Peter G
authors.initials: PG
authors.lastname: Atanassoff
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000577:Amides / Q000008:administration & dosage*; D001340:Autonomic Nerve Block / Q000379:methods*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000187:drug effects* / Q000502:physiology / Q000601:surgery; D008297:Male; D008619:Mepivacaine / Q000008:administration & dosage*; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy; D000077212:Ropivacaine; D012584:Sciatic Nerve / Q000187:drug effects* / Q000502:physiology; D018709:Statistics, Nonparametric
chemical_list: D000577:Amides; D000077212:Ropivacaine; D008619:Mepivacaine