[Role of matrix metalloproteinase-2 and components of the extracellular matrix--collagen type IV and laminin expression in detection of the invasive potential of pancreatic tumors].
Invasive potential of ductal tumors (adenocarcinoma, mucinous-cystic tumors, gastrinoma and undifferentiated tumors) positively correlated with the degree of metalloproteinase-2 expression and negatively correlated with stromal content of type IV collagen.
Gurevich
L E
LE
M.F. Vladimirsky Moscow Regional Clinical Institute, Research Institute of Human Morphology, Moscow.
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology*; D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000473:pathology; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D018278:Carcinoma, Neuroendocrine / Q000378:metabolism / Q000473:pathology; D024141:Collagen Type IV / Q000096:biosynthesis; D005109:Extracellular Matrix / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000096:biosynthesis; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis; D009361:Neoplasm Invasiveness; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor; D024141:Collagen Type IV; D016326:Extracellular Matrix Proteins; D007797:Laminin; D020778:Matrix Metalloproteinase 2