Use of a telemetry system to examine recovery of the cardiovascular system after excitement induced by handling stress in a conscious cynomolgus monkey (Macaca fascicularis).
The aim of this study was to determine the time required for the cardiovascular system of a conscious cynomolgus monkey, in which a telemetry had been implanted, to recover from excitement induced by handling stress. With enforcement of guidelines regarding safety pharmacological studies, cardiovascular studies in primates have become more important. However, as macaque monkeys are promptly excited under experimental procedures, it is often difficult to evaluate the drug effects on the cardiovascular system. Therefore, we tested monkey chair restraint and intravenous injection of saline. After monkey chair restraint and intravenous injection, approximately 30 minutes were required for recovery of both heart rate and blood pressure to their pre-treatment level; however, ECG parameters such as PR, QRS interval, and QTc did not drastically change. Based on our current results and with sufficient consideration of autonomic nervous effects, accurate evaluation of drug effects on the cardiovascular system should now be possible.
Hassimoto
M
M
Toxicology Laboratory, Research Center, Mochida Pharmaceutical Co., Ltd, Shizuoka, Japan. hassie-dvm@umin.ac.jp
Harada
T
T
D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D004562:Electrocardiography / Q000662:veterinary; D006234:Handling, Psychological; D006339:Heart Rate / Q000502:physiology; D008252:Macaca fascicularis / Q000502:physiology*; D013686:Telemetry / Q000379:methods*