Prognostic value of combination of cardiac troponin T and B-type natriuretic peptide after initiation of treatment in patients with chronic heart failure.
BACKGROUND
Recent studies have suggested that cardiac troponin T (cTnT) and troponin I may detect ongoing myocardial damage involved in the progression of chronic heart failure (CHF). This study was prospectively designed to examine whether the combination of cTnT, a marker for ongoing myocardial damage, and B-type natriuretic peptide (BNP), a marker for left ventricular overload, would effectively stratify patients with CHF after initiation of treatment.


METHODS
We measured serum cTnT, plasma BNP, and left ventricular ejection fraction (LVEF) on admission for worsening CHF [New York Heart Association (NYHA) functional class III to IV] and 2 months after initiation of treatment to stabilize CHF (n = 100; mean age, 68 years).


RESULTS
Mean (SD) concentrations of cTnT [0.023 (0.066) vs 0.063 (0.20) micro g/L] and BNP [249 (276) vs 753 (598) ng/L], percentage increased cTnT (>0.01 micro g/L; 35% vs 60%), NYHA functional class [2.5 (0.6) vs 3.5 (5)], and LVEF [43 (13)% vs 36 (12)%] were significantly (P <0.01) improved 2 months after treatment compared with admission. During a mean follow-up of 391 days, there were 44 cardiac events, including 12 cardiac deaths and 32 readmissions for worsening CHF. On a stepwise Cox regression analysis, increased cTnT and BNP were independent predictors of cardiac events (P <0.001). cTnT >0.01 micro g/L and/or BNP >160 ng/L 2 months after initiation of treatment were associated with increased cardiac mortality and morbidity rates.


CONCLUSIONS
The combination of cTnT and BNP measurements after initiation of treatment may be highly effective for risk stratification in patients with CHF.
Ishii
Junnichi
J
Division of Critical Care, Fujita Health University Graduate School of Health Sciences, Toyoake 470-1192, Japan. jishi@fujita-hu.ac.jp
Cui
Wei
W
Kitagawa
Fumihiko
F
Kuno
Takahiro
T
Nakamura
Yuu
Y
Naruse
Hiroyuki
H
Mori
Yoshihisa
Y
Ishikawa
Takashi
T
Nagamura
Youichi
Y
Kondo
Takeshi
T
Oshima
Hisaji
H
Nomura
Masanori
M
Ezaki
Kouji
K
Hishida
Hitoshi
H
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D005260:Female; D006333:Heart Failure / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D006801:Humans; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010359:Patient Readmission / Q000706:statistics & numerical data; D011237:Predictive Value of Tests; D011446:Prospective Studies; D018570:Risk Assessment; D020107:Troponin T / Q000097:blood*; D016277:Ventricular Function, Left
D015415:Biomarkers; D020107:Troponin T; D020097:Natriuretic Peptide, Brain