title: Depression in adult women: age changes and cohort effects.
abstract: OBJECTIVE
  We sought to separate age and cohort associations with depression, assessed 3 times within a 10-year period in 701 women born between 1928 and 1958.
  
  
  METHODS
  We used regression analysis to examine age differences in women with depression in 2 birth cohorts, pre-1945 and post-1944, who were assessed at comparable ages. Multilevel modeling was used to estimate changes with age in successive birth year cohorts.
  
  
  RESULTS
  An age by cohort interaction indicated more depression among younger than older women in the post-1944 cohort but a flat age profile in the pre-1945 cohort. Longitudinal analyses indicated declines in depression with age in more recent cohorts but increases in earlier ones.
  
  
  CONCLUSIONS
  Increases in depression in younger women in successive cohorts may be offset by decreases in middle age.
authors.affiliation: Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. kasenst@pi.cpmc.columbia.edu
authors.forename: Stephanie
authors.initials: S
authors.lastname: Kasen
authors.forename: Patricia
authors.initials: P
authors.lastname: Cohen
authors.forename: Henian
authors.initials: H
authors.lastname: Chen
authors.forename: Dorothy
authors.initials: D
authors.lastname: Castille
mesh_terms: D000328:Adult; D000367:Age Factors; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000453:epidemiology*; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017533:Marital Status; D008875:Middle Aged; D009518:New York / Q000453:epidemiology; D012307:Risk Factors; D016387:Women's Health