title: Genome-wide screen in obese pedigrees with type 2 diabetes mellitus from a defined Dutch population.
abstract: A genome scan was performed in obese type 2 diabetes mellitus pedigrees to identify susceptibility loci involved in obesity-driven type 2 diabetes mellitus. We studied the 20% most obese diabetes pedigrees from a confined Dutch population from around the town of Breda. Previously we, and others, have already shown that a susceptibility locus influencing obesity in diabetes may reside on chromosome 18p11. We now report evidence to also suggest linkage for type 2 diabetes in these obese pedigrees on chromosome regions 11p (genome-wide P-value </= 0.061) and 12q (genome-wide P-value </= 0.029), thereby confirming previous findings from corresponding regions. The linkage found in the Breda Cohort of type 2 diabetes patients is influenced by obesity. This supports the notion that a genetic predisposition to obesity is probably intertwined with a genetic predisposition to type 2 diabetes. Further efforts should address the question of how, on a genetic level, these two factors interact.
authors.affiliation: University Medical Center, Utrecht, The Netherlands.
authors.forename: J H
authors.initials: JH
authors.lastname: van Tilburg
authors.forename: L A
authors.initials: LA
authors.lastname: Sandkuijl
authors.forename: L
authors.initials: L
authors.lastname: Franke
authors.forename: E
authors.initials: E
authors.lastname: Strengman
authors.forename: P L
authors.initials: PL
authors.lastname: Pearson
authors.forename: T W
authors.initials: TW
authors.lastname: van Haeften
authors.forename: C
authors.initials: C
authors.lastname: Wijmenga
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D015331:Cohort Studies; D003920:Diabetes Mellitus / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D016014:Linear Models; D008875:Middle Aged; D009765:Obesity; D010375:Pedigree