title: Microbial transformation of baccatin VI and 1beta-hydroxy baccatin I by Aspergillus niger.
abstract: The biotransformation of baccatin VI (1) and 1beta-hydroxybaccatin I (2) with the filamentous fungus Aspergillus niger produced four new taxane diterpenoids taxumairol S(1) (3), taxumairol T(1) (4) and taxumairol S (5), taxumairol T (6), respectively. 1beta-Dehydroxybaccatin VI (7) remained unreacted under the same condition.
authors.affiliation: Institute of Marine Resources, National Sun Yat-sen University, 70 Lien Hai Road, Kaohsiung 80424, Taiwan ROC. ycshen@mail.nsysu.edu.tw
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
authors.forename: Kuang-Liang
authors.initials: KL
authors.lastname: Lo
authors.forename: Chun-Ling
authors.initials: CL
authors.lastname: Lin
authors.forename: Rupak
authors.initials: R
authors.lastname: Chakraborty
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000493:pharmacokinetics*; D001234:Aspergillus niger / Q000378:metabolism*; D001711:Biotransformation; D004224:Diterpenes / Q000493:pharmacokinetics; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000493:pharmacokinetics*; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D043823:Taxoids / Q000493:pharmacokinetics; D014121:Toxoids / Q000737:chemistry / Q000493:pharmacokinetics*
chemical_list: C488272:1beta-hydroxy baccatin I; D000470:Alkaloids; D004224:Diterpenes; D006576:Heterocyclic Compounds, 4 or More Rings; D007202:Indicators and Reagents; D043823:Taxoids; D014121:Toxoids; C488271:baccatin VI