title: GDNF and bFGF are differentially involved in glial cell differentiation and neurite bundle formation in cultures from chick embryonic ciliary ganglia.
abstract: We have shown that the neurotrophic factors glial cell line-derived neurotrophic factor (GDNF) and basic fibroblast growth factor (bFGF) exert different effects on glial cells in cultures from chick embryo ciliary ganglia. bFGF acts as a mitogen on glial cells, and induces their aggregation to neuronal bodies; after 48 h of culture no glial cells could be observed along neurites. GDNF has no proliferative role; in contrast, it promotes the expression of the differentiative marker O4 and the association of glial cell bodies to neurites to form robust bundles.
authors.affiliation: Dipartimento di Biologia Animale e dell'Uomo, I-10123 Turin, Italy.
authors.forename: Pollyanna
authors.initials: P
authors.lastname: Zamburlin
authors.forename: Alessandra
authors.initials: A
authors.lastname: Gilardino
authors.forename: Paolo
authors.initials: P
authors.lastname: Ariano
authors.forename: Davide
authors.initials: D
authors.lastname: Lovisolo
authors.forename: Carla
authors.initials: C
authors.lastname: Distasi
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology*; D002478:Cells, Cultured; D002642:Chick Embryo; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology* / Q000502:physiology; D005724:Ganglia / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors / Q000494:pharmacology* / Q000502:physiology; D016501:Neurites / Q000187:drug effects / Q000502:physiology; D009457:Neuroglia / Q000166:cytology* / Q000187:drug effects; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000502:physiology
chemical_list: D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D016222:Fibroblast Growth Factor 2