title: Olefin metathesis in glycobiology: new routes towards diverse neoglycoconjugates.
abstract: This report provides a historical overview of the implementation of olefin metathesis in carbohydrate chemistry, with the emphasis on the construction of neoglycoconjugates. The current state-of-the-art in catalyst design allows the preparation of carbohydrate-containing molecules with great structural and functional diversity. Recent examples of complex neoglycoconjugates, including glycopolymers, glycoclusters, glycopeptide and glycolipid analogues are highlighted. Finally, future perspectives in the scope of olefin metathesis mediated neoglycoconjugate synthesis are discussed.
authors.affiliation: Leiden Institute of Chemistry, Leiden University, PO Box 9502, 2300 RA, Leiden, The Netherlands.
authors.forename: Michiel A
authors.initials: MA
authors.lastname: Leeuwenburgh
authors.forename: Gijsbert A
authors.initials: GA
authors.lastname: van der Marel
authors.forename: Herman S
authors.initials: HS
authors.lastname: Overkleeft
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D001669:Biochemical Phenomena; D001671:Biochemistry; D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000138:chemical synthesis; D006001:Glycoconjugates / Q000138:chemical synthesis*; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D009942:Organometallic Compounds / Q000737:chemistry
chemical_list: D000475:Alkenes; D002241:Carbohydrates; D006001:Glycoconjugates; D009942:Organometallic Compounds