title: The interleukin-1 gene family in multiple sclerosis susceptibility and disease course.
abstract: Multiple sclerosis (MS) is a chronic disease of presumed autoimmune origin with a considerable polygenic influence. We have previously observed that a specific allele combination in genes of the interleukin-1 (IL-1) family influenced the progression rate in MS. We have considerably expanded our patient population (492 MS patients and 228 controls). In the present study, we investigated the role of the IL-IA--889, IL-1B--511, IL-1B f3953 and IL-1RN VNTR gene polymorphisms in MS. In addition, we performed preliminary analyses on longitudinal magnetic resonance imaging (MRI) data. We found no associations between the polymorphisms and susceptibility to MS or clinical features. In addition, we observed no significant effect of the polymorphisms on brain or lesion volumes, Based on our data and those from the literature, one can conclude that there is currently no evidence to support a role for the IL-1 genes in MS.
authors.affiliation: Department of Neurology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands. T.Hooper-vanVeen@vumc.nl
authors.forename: Tineke
authors.initials: T
authors.lastname: Hooper-van Veen
authors.forename: Hans M
authors.initials: HM
authors.lastname: Schrijver
authors.forename: Antoon
authors.initials: A
authors.lastname: Zwiers
authors.forename: J Bart A
authors.initials: JB
authors.lastname: Crusius
authors.forename: Dirk L
authors.initials: DL
authors.lastname: Knol
authors.forename: Nynke F
authors.initials: NF
authors.lastname: Kalkers
authors.forename: Marja L
authors.initials: ML
authors.lastname: Laine
authors.forename: Frederik
authors.initials: F
authors.lastname: Barkhof
authors.forename: A Salvador
authors.initials: AS
authors.lastname: Peña
authors.forename: Chris H
authors.initials: CH
authors.lastname: Polman
authors.forename: Bernard M J
authors.initials: BM
authors.lastname: Uitdehaag
mesh_terms: D000328:Adult; D000483:Alleles; D004843:Epistasis, Genetic; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D005810:Multigene Family / Q000235:genetics; D009103:Multiple Sclerosis / Q000235:genetics* / Q000473:pathology
chemical_list: D007375:Interleukin-1