Highly enantioselective alkaloid synthesis via ene-type cyclizations catalyzed by cationic chiral palladium(II) complexes of PN-ligands with an achiral oxazoline unit.
A highly efficient asymmetric alkaloid synthesis via ene-type cyclizations catalyzed by cationic chiral palladium(II) complexes of PN-ligands with an achiral gem-dimethyl oxazoline unit is shown to give 5-membered products with a quaternary carbon center, including a spiro-amide, almost quantitatively with extremely high enantiomeric excesses.
Hatano
Manabu
M
Department of Applied Chemistry, Graduate School of Science and Technology, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo 152-8552, Japan.
Mikami
Koichi
K