title: New synthesis of optically active 5-isoxazolidinones and beta-amino acids.
abstract: A new simple and stereoselective synthesis of 5-isoxazolidinones based on the reaction of lithiated 2-isopropyl-2-oxazolines with nitrones is described. A chiral version of such a methodology allows the preparation of highly enantioenriched 5-isoxazolidinones which are useful precursors for the synthesis of beta-amino acids
authors.affiliation: Dipartimento Farmaco-Chimico, Università degli Studi di Bari, Via E. Orabona 4, I-70126 Bari, Italy.
authors.forename: Renzo
authors.initials: R
authors.lastname: Luisi
authors.forename: Vito
authors.initials: V
authors.lastname: Capriati
authors.forename: Saverio
authors.initials: S
authors.lastname: Florio
authors.forename: Teresa
authors.initials: T
authors.lastname: Vista
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D006571:Heterocyclic Compounds / Q000737:chemistry; D008956:Models, Chemical; D009589:Nitrogen Oxides / Q000737:chemistry; D023303:Oxazolidinones / Q000138:chemical synthesis*; D013141:Spiro Compounds / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D006571:Heterocyclic Compounds; D009589:Nitrogen Oxides; D023303:Oxazolidinones; D013141:Spiro Compounds; C015388:nitrones