Orphanin FQ/nociceptin blocks methamphetamine place preference in rats.
Orphanin FQ/nociceptin (NOC) has been reported to regulate dopaminergic neurotransmission in rewarding pathway, and to suppress the development of conditioned place preference (CPP) induced by certain addictive drugs. In this study, we investigated the effect of NOC on CPP induced by repeated administration of methamphetamine (MAP) in rats. Repeated administration of MAP (1 mg/kg, i.p.) induced substantial CPP. MAP-induced CPP was completely suppressed by NOC (10 nmol, i.c.v.). Pretreatment with [Nphe1]nociceptin(1-13)NH2 (50 nmol, i.c.v.), an antagonist of the NOC receptor, antagonized the suppressive effect of NOC on MAP-induced CPP. These results suggest that NOC blocks MAP-induced CPP by activation of the NOC receptor.
Zhao
Rong-Jie
RJ
Department of Pharmacology, Chonbuk National University Medical School, Chonju, Republic of Korea.
Woo
Ran-Sook
RS
Jeong
Min-Suk
MS
Shin
Byoung-Soo
BS
Kim
Dong-Goo
DG
Kim
Kee-Won
KW
D000818:Animals; D016739:Behavior, Addictive / Q000188:drug therapy / Q000523:psychology; D003213:Conditioning, Psychological / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D018847:Opioid Peptides / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D000097629:Nociceptin
D008694:Methamphetamine; D018847:Opioid Peptides; D000097629:Nociceptin