title: Paget's disease.
abstract: A review of the signs, symptoms, and treatment of Paget's disease is presented. Paget, or osteitis deformans, is a chronic, progressive, bone disease of viral etiology. Recent investigations about the causative agent of this disorder have implicated the measles virus of the paramyxovirus family. Additional studies have demonstrated that abnormal virus-infected osteoclasts generate interleukin (IL)-6, a resorptive cytokine from the bone marrow of patients with Paget's bone disease.
authors.affiliation: Department of Dental Medicine, Albert Einstein Medical Center, Philadelphia, PA, USA.
authors.forename: I B
authors.initials: IB
authors.lastname: Bender
mesh_terms: D006801:Humans; D007571:Jaw Diseases / Q000175:diagnosis* / Q000188:drug therapy; D010001:Osteitis Deformans / Q000175:diagnosis* / Q000188:drug therapy; D014076:Tooth Diseases / Q000175:diagnosis* / Q000188:drug therapy