Eruptive large melanocytic nevus in a patient with hereditary epidermolysis bullosa simplex.
Hereditary epidermolysis bullosa (HEB) is a group of genetically determined mechanobullous disorders characterized by blister formation following minor trauma. Unusual melanocytic lesions may be a rare feature of all major categories of HEB. We report a large melanocytic nevus, clinically simulating malignant melanoma, which developed at a site of healing blisters in an 8-year-old male with recessive generalized epidermolysis bullosa simplex (EBS). Histological findings were consistent with a compound nevus. This is the third reported case of an eruptive melanocytic nevus developing in EBS. Due to their unique features, it has been suggested that these nevi may represent a distinct variant, referred to as epidermolysis bullosa nevi. Despite the atypical picture, no malignant transformation of HEB nevi has been seen. Therefore, after histologic verification, regular long-term follow-up rather than radical surgery is recommended.
Stavrianeas
N G
NG
Department of Dermatology and Venereology, A. Sygros Hospital, National and Kapodistrian University of Athens, Athens, Greece. dr_stravianeas@hotmail.com
Katoulis
A C
AC
Moussatou
V
V
Bozi
E
E
Petropoulou
H
H
Limas
C
C
Georgala
S
S
D002648:Child; D016110:Epidermolysis Bullosa Simplex / Q000150:complications*; D006801:Humans; D008297:Male; D009508:Nevus, Pigmented / Q000209:etiology*