Low doses of topiramate are effective in essential tremor: a report of three cases.
We here report on 3 patients with essential tremor, otherwise unresponsive to pharmacological treatment, who greatly benefited from low doses of topiramate (50 mg/d). No side effects were observed and improvement was sustained during a mean of 7 months (range 3-12 months) follow up. Our results suggest that topiramate titration should be performed gradually, so as not to neglect cases responsive to low doses.
Gatto
Emilia M
EM
Parkinson's Disease and Movement Disorders Unit, Institute of Applied Neurosciences, José de San Martin Hospital de Clinicas, Buenos Aires, Argentina.
Roca
M Claudia Uribe
MC
Raina
Gabriela
G
Micheli
Federico
F
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000368:Aged; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000150:complications / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D020329:Essential Tremor / Q000188:drug therapy*; D005632:Fructose / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D009483:Neuropsychological Tests; D011324:Primidone / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D000077236:Topiramate
D000319:Adrenergic beta-Antagonists; D000927:Anticonvulsants; D018696:Neuroprotective Agents; D000077236:Topiramate; D011324:Primidone; D005632:Fructose; D011433:Propranolol