title: [A case of severe Chlamydia pneumoniae pneumonia requiring mechanical ventilation and complicated with disseminated intravascular coagulation].
abstract: A previously healthy 48-year-old man presented to his primary care physician with high fever, dry cough and dyspnea. Pneumonia was diagnosed and intravenous administration of imipenem/cilastatin was begun, but his respiratory condition worsened and he was admitted to our hospital with severe hypoxia. A chest radiograph showed reticular opacity and consolidation in both lung fields. The case was complicated with disseminated intravascular coagulation. Analysis of the bronchoalveolar lavage fluid showed increases in the total cell counts and an elevated percentage of lymphocytes. Sputum, blood and bronchoalveolar lavage examinations failed to reveal etiology to explain his severe respiratory illness. Treatment consisted of mechanical ventilation and administration of steroid pulse-therapy and gabexate mesilate. On the basis of his clinical course, we suspected possible atypical pneumonia, and began therapy with intravenous minocyclin and oral erythromycin administration. On the third hospital day, the arterial blood gas data improved and the bilateral pulmonary infiltration on the chest radiographs disappeared. Using paired sera, we detected increases of 1.35 in ID for anti-Chlamydia pneumoniae IgG antibodies by ELISA, and arrived at a diagnosis of Chlamydia pneumoniae pneumonia.
authors.affiliation: Third Department of Internal Medicine, Miyazaki Medical College, Kiyotake 5200, Miyazaki 889-1692, Japan.
authors.forename: Shigehisa
authors.initials: S
authors.lastname: Yanagi
authors.forename: Junichi
authors.initials: J
authors.lastname: Ashitani
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Arimura
authors.forename: Arisa
authors.initials: A
authors.lastname: Sano
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kato
mesh_terms: D000208:Acute Disease; D023521:Chlamydophila Infections / Q000150:complications / Q000382:microbiology / Q000628:therapy*; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification; D004211:Disseminated Intravascular Coagulation / Q000209:etiology* / Q000628:therapy; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000008:administration & dosage; D016670:Gabexate / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D008911:Minocycline / Q000008:administration & dosage; D018410:Pneumonia, Bacterial / Q000150:complications / Q000382:microbiology / Q000628:therapy*; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D016670:Gabexate; D004917:Erythromycin; D008911:Minocycline; D008775:Methylprednisolone