Caspofungin activity against clinical isolates of fluconazole-resistant Candida.
A total of 7,837 clinical isolates of Candida were tested against fluconazole, and 351 resistant (fluconazole MIC >/=64 micro g/ml) isolates were identified (4% of the total tested). All fluconazole-resistant isolates were inhibited by caspofungin at concentrations that can be exceeded by standard doses (MIC at which 90% of the isolates were inhibited, 1 micro g/ml; 99% of the MICs were </=2 micro g/ml).
Pfaller
Michael A
MA
Departments of Pathology, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa 52242, USA.
Messer
Shawn A
SA
Boyken
Linda
L
Rice
Cassie
C
Tendolkar
Shailesh
S
Hollis
Richard J
RJ
Diekema
Daniel J
DJ
D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification; D041221:Candida glabrata / Q000187:drug effects / Q000302:isolation & purification; D000077336:Caspofungin; D004352:Drug Resistance, Microbial / Q000502:physiology*; D054714:Echinocandins; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000494:pharmacology*; D010456:Peptides, Cyclic
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010455:Peptides; D010456:Peptides, Cyclic; D015725:Fluconazole; D000077336:Caspofungin