title: Automated quantification of mitral valve regurgitation based on normalized centerline velocity distribution.
abstract: Previous echocardiographic techniques for quantifying valvular regurgitation are limited by factors including uncertainties for orifice location and a hemispheric convergence assumption that often results in over- and underestimation of flow rate and regurgitant orifice area. Using computational fluid dynamics simulations, these factors were eliminated, allowing a more accurate assessment of regurgitation. A model was developed to allow automated quantification of regurgitant orifice diameter based on the centerline velocity data available from color M-mode echocardiography. The model, validated using in vitro unsteady flow data, demonstrated improved accuracy for orifice diameter (y=0.95x + 0.38, r=0.96) and volume (y=1.18x - 4.72, r=0.93).
authors.affiliation: The Cleveland Clinic Foundation, Cleveland, Ohio, USA.
authors.forename: D
authors.initials: D
authors.lastname: Deserranno
authors.forename: N L
authors.initials: NL
authors.lastname: Greenberg
authors.forename: J D
authors.initials: JD
authors.lastname: Thomas
authors.forename: M J
authors.initials: MJ
authors.lastname: Garcia
mesh_terms: D001783:Blood Flow Velocity; D003198:Computer Simulation; D018618:Echocardiography, Doppler, Color / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology; D008944:Mitral Valve Insufficiency / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity