Complete hydatidiform mole in a triplet pregnancy coexisting two viable fetuses: case report and review of the literature.
We report a rare case of a complete hydatidiform mole with two or more coexisting fetuses where both infants survived without complications. A male infant weighing 1258 g and a female infant weighing 880 g were delivered without complications and discharged 95 days after the birth. The analysis of DNA microsatellite polymorphisms indicated that the mole was of paternal origin and probably homozygous. The mother suffered from multiple pulmonary metastasis of the hydatidiform mole which was detected 3 days after the surgery and was successfully treated with methotrexate. A complete hydatidiform mole with two or more coexisting fetuses produces a dilemma between immediate termination and pregnancy continuation. Although the present case resulted in a favorable outcome, a review of the 14 reported cases suggests that the high fetal loss rate (90%) must be a consideration in the decision regarding management of such a pregnancy.
Takagi
Kimiyo
K
Department of Obstetrics, Center for Perinatal Medicine, Nagano Children's Hospital, Japan.
Unno
Nobuya
N
Hyodo
Hiro-e M
HE
Hyodo
Hironobu
H
Kashima
Hiroyasu
H
Kubota
Noriko
N
Ogiso
Yoshihumi
Y
Noike
Masami
M
Itoh
Kazuko
K
Shiobara
Shigeki
S
Konishi
Ikuo
I
Saito
Shigeru
S
D000328:Adult; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D014310:Triplets; D014463:Ultrasonography