title: [Gene expression profile changes in human multiple myeloma].
abstract: OBJECTIVE
  To determine the difference in gene expression between human multiple myeloma (MM) and normal bone marrow.
  
  
  METHODS
  cDNA chip was used to detect the mRNA of mononuclear cell from 10 untreated MM patients and 10 cases of normal bone marrow.
  
  
  RESULTS
  Of the 2,048 genes, we found 566 different expression genes, of which the expression of 237 genes was higher and 329 lower in MM than in the normal bone marrow.
  
  
  CONCLUSIONS
  Many genes may be involved in the pathogenesis of MM. cDNA chip technology is an effective tool in the study of tumor related genes.
authors.affiliation: Molecular Biology Research Center, Xiangya School of Medicine, Central South University, Changsha 410078, China.
authors.forename: Yi-wu
authors.initials: YW
authors.lastname: Shi
authors.forename: Wei-xin
authors.initials: WX
authors.lastname: Hu
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Tang
mesh_terms: D000328:Adult; D000368:Aged; D001897:Boronic Acids; D000069286:Bortezomib; D004815:Epidermal Growth Factor / Q000096:biosynthesis / Q000235:genetics; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D066257:Heparin-binding EGF-like Growth Factor; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics*; D009687:Nuclear Proteins / Q000096:biosynthesis / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D017027:Protein Tyrosine Phosphatases / Q000096:biosynthesis / Q000235:genetics; D011719:Pyrazines; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics
chemical_list: D001897:Boronic Acids; C587883:HBEGF protein, human; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; C100853:MLF2 protein, human; D009687:Nuclear Proteins; D011719:Pyrazines; D012333:RNA, Messenger; D004815:Epidermal Growth Factor; D000069286:Bortezomib; D017027:Protein Tyrosine Phosphatases