The effects of antipyretics on influenza virus encephalitis in mice and chicks.
To investigate the effect of antipyretics on the murine and poultry models of influenzal encephalitis, we injected large quantities of antipyretics, acetylsalicylic acid (aspirin) and dicrofenac sodium (voltaren). The effect of antipyretic treatment on the murine encephalitis model was unremarkable histologically and immunohistochemically. Whereas in chicks, CNS lesions consisting of perivascular cuffing and gliosis appeared only in those animals treated with the antipyretics and viral antigen was detected mainly in the nuclei of glial cells or vascular endothelia of voltaren-treated animals. We here demonstrate that antipyretic treatment aggravated the hematogenous spread of the influenza virus to the CNS in chicks, but did not affect the transneural infection in mice.
Sunden
Yuji
Y
Laboratory of Comparative Pathology, School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Park
C H
CH
Matsuda
Kazuya
K
Anagawa
Akiko
A
Kimura
Takashi
T
Ochiai
Kenji
K
Kida
Hiroshi
H
Umemura
Takashi
T
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001241:Aspirin / Q000627:therapeutic use; D002645:Chickens; D004008:Diclofenac / Q000627:therapeutic use; D004195:Disease Models, Animal; D018792:Encephalitis, Viral / Q000188:drug therapy* / Q000662:veterinary*; D006652:Histological Techniques; D007150:Immunohistochemistry; D009980:Influenza A virus; D005585:Influenza in Birds / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D001241:Aspirin