title: Glycosyl phenylthiosulfonates (glyco-PTS): novel reagents for glycoprotein synthesis.
abstract: Controlled site-selective glycosylation can be achieved by combining site-directed cysteine mutagenesis with chemical modification of the introduced thiol; a new class of more efficient chemoselective reagents, glycosyl phenylthiosulfonates, allow rapid glycosylations of representative simple thiols, peptides and proteins.
authors.affiliation: Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, UK OX1 3QY.
authors.forename: David P
authors.initials: DP
authors.lastname: Gamblin
authors.forename: Philippe
authors.initials: P
authors.lastname: Garnier
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Ward
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Oldham
authors.forename: Antony J
authors.initials: AJ
authors.lastname: Fairbanks
authors.forename: Benjamin G
authors.initials: BG
authors.lastname: Davis
mesh_terms: D006023:Glycoproteins / Q000138:chemical synthesis*; D007202:Indicators and Reagents / Q000737:chemistry*; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D013886:Thiosulfonic Acids / Q000737:chemistry*
chemical_list: D006023:Glycoproteins; D007202:Indicators and Reagents; D013886:Thiosulfonic Acids