title: [Living donor liver transplantation treatment of Wilson's disease complicated with neuropathy].
abstract: OBJECTIVE
  To investigate living donor liver transplantation for Wilson disease with neurologic features.
  
  
  METHODS
  From Jan 2001 to Mar 2003, fifteen cases of living donor liver transplantation were performed for Wilson Disease (WD), five of those were complicated with neurologic features. A retrospective analysis was given for cooper metabolism and neurologic features.
  
  
  RESULTS
  All operation were living related liver transplantation and donors were mothers. Four left lobes with hepatic middle vein and one right lobe without hepatic middle vein were harvested from donors, and graft volume to recipient body weight ratio was 0.79 approximately 1.08. One patient occurred hepatic artery thrombosis and performed retransplantation later, the other recipients recovered satisfactorily. All patients showed Extrapyramidal sign and three patients companying with language handicap and dyskinesia alleviated postoperation follow-up between 2 and 16 months. All recipients are alive and remain well, and none have developed signs of recurrent WD.
  
  
  CONCLUSIONS
  Living donor liver transplantation is effective treatment for WD complicated with nervous system symptom, ceruloplasmin is normal and Kayser-Fleischer ring and nervous system symptom are to various extents.
authors.affiliation: Liver Transplantation Center, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Xue-hao
authors.initials: XH
authors.lastname: Wang
authors.forename: Feng
authors.initials: F
authors.lastname: Cheng
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Xiang-cheng
authors.initials: XC
authors.lastname: Li
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Qian
authors.forename: Lian-bao
authors.initials: LB
authors.lastname: Kong
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Guo-qiang
authors.initials: GQ
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D002570:Ceruloplasmin / Q000032:analysis; D002648:Child; D003300:Copper / Q000097:blood; D005260:Female; D006527:Hepatolenticular Degeneration / Q000601:surgery*; D006801:Humans; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000601:surgery*
chemical_list: D003300:Copper; D002570:Ceruloplasmin