title: [Systemic infection of Aspergillus flavus in a patient with acute lymphoblastic leukemia].
abstract: A 57-year-old woman with acute lymphoblastic leukemia (ALL) developed an antibiotics-resistant fever after remission induction therapy. Chest X-ray and computed tomography scan revealed multiple consolidations and cavities. Successively, numerous subcutaneous nodules and a thyroid mass emerged. Aspergillus flavus (A. flavus) was cultured from both sites. Despite the patient's granulocyte recovery, the fever persisted and multiorgan function deteriorated rapidly. However, she was successfully treated with intensive supportive therapy including continuous hemodialysis and filtration. Prolonged use of amphoterin B and itraconazole failed to cure her aspergillosis, but the illness remained indolent thereafter.
authors.affiliation: Department of Hematology and Oncology, JA Aichi Showa Hospital, Konan.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Narimatsu
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Morishita
authors.forename: Akio
authors.initials: A
authors.lastname: Kohno
authors.forename: Shigeki
authors.initials: S
authors.lastname: Saito
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Shimada
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ozeki
authors.forename: Keiji
authors.initials: K
authors.lastname: Funahashi
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kato
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D001228:Aspergillosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D001231:Aspergillus flavus; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000473:pathology
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B