title: Methylene 3, 4 dioxymethamphetamine-induced acute myocardial infarction.
abstract: Methylene 3, 4 dioxymethamphetamine (MDMA) has been gaining popularity as a recreational drug over the past few decades around the globe. Although once thought to be safer than its mother compound, amphetamine, several life-threatening adverse reactions have been reported. Among the cardiovascular toxicities documented, MDMA commonly causes various forms of arrhythmia and heart failure. However, MDMA-induced acute myocardial infarction is rarely reported. We report a case of acute myocardial infarction in a young man shortly after taking MDMA. Massive thrombosis over the right coronary artery was demonstrated by means of emergency angiography. After treatment with intravenous glycoprotein IIb/IIIa inhibitor and intracoronary urokinase infusion, the coronary artery was shown to be patent without any apparent stenotic lesions. The mechanism of MDMA-induced acute myocardial infarction was discussed.
authors.affiliation: Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Republic of China.
authors.forename: Ting-I
authors.initials: TI
authors.lastname: Lai
authors.forename: Juey-Jen
authors.initials: JJ
authors.lastname: Hwang
authors.forename: Cheng-Chung
authors.initials: CC
authors.lastname: Fang
authors.forename: Wen-Jone
authors.initials: WJ
authors.lastname: Chen
mesh_terms: D000284:Administration, Oral; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D006328:Cardiac Catheterization; D017023:Coronary Angiography; D003402:Creatine Kinase / Q000032:analysis; D004562:Electrocardiography; D006213:Hallucinogens / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood / Q000652:urine; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects* / Q000097:blood / Q000652:urine; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood / Q000652:urine; D016896:Treatment Outcome; D019210:Troponin I / Q000032:analysis
chemical_list: D015415:Biomarkers; D006213:Hallucinogens; D013287:Illicit Drugs; D019210:Troponin I; D003402:Creatine Kinase; D018817:N-Methyl-3,4-methylenedioxyamphetamine