title: [A comparative study of the treatment of high grade gliomas].
abstract: BACKGROUND
  The influence of surgery, radiotherapy and/or chemotherapy on the outcome on the results in patients with malignant gliomas is controversial.
  
  
  METHODS
  We studied 44 patients (26, women; 18 men; age 38 72 years) diagnosed with grades III and IV astrocytoma who had been operated and then received adjuvant radiotherapy and either BCNU or temozolamyde chemotherapy. Survival time and adverse effects of the chemotherapy were analysed.
  
  
  CONCLUSIONS
  Aggressive surgery associated with radiotherapy and temozolamyde chemotherapy prolonged survival in our patients with malignant astrocytomas.
authors.affiliation: Servicio de Neurocirugía, Hospital Universitario La Paz, Madrid, España. neurobudke@yahoo.es
authors.forename: M
authors.initials: M
authors.lastname: Budke
authors.forename: A
authors.initials: A
authors.lastname: Isla-Guerrero
authors.forename: C
authors.initials: C
authors.lastname: Pérez-López
authors.forename: M
authors.initials: M
authors.lastname: Pérez-Alvarez
authors.forename: A
authors.initials: A
authors.lastname: García-Grande
authors.forename: M J
authors.initials: MJ
authors.lastname: Bello
authors.forename: J
authors.initials: J
authors.lastname: Rey
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D001254:Astrocytoma / Q000401:mortality / Q000628:therapy*; D001932:Brain Neoplasms / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents