title: Serum adrenal androgens in women with primary operable breast cancer and their relationship with age and body mass index.
abstract: Several studies have found elevated levels of adrenal androgens in postmenopausal women and depressed levels in premenopausal women with breast cancer, suggesting a role for adrenal androgens in the aetiology of breast cancer. We have measured serum dehydroepiandrosterone sulphate and androstenedione in 81 women with primary operable breast cancer and 62 age-matched controls. Results showed that serum levels of both adrenal androgens fell significantly with age in women with breast cancer (P=0.003). However, no relationship was observed between serum adrenal androgen levels and body mass index in either women with breast cancer or controls. Dehydroepiandrosterone sulphate levels were elevated in postmenopausal women with breast cancer compared to controls, and this was not due to preoperative stress. No differences were observed in androstenedione levels between premenopausal or postmenopausal women with breast cancer and controls, nor were dehydroepiandrostenedione sulphate levels significantly different between premenopausal women with breast cancer and controls. These results suggest that dehydroepiandrosterone sulphate has a role in the aetiology of postmenopausal breast cancer.
authors.affiliation: School of Surgery and Reproductive Sciences, The Medical School, University of Newcastle, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK. sebaspinall@tiscali.co.uk
authors.forename: S R
authors.initials: SR
authors.lastname: Aspinall
authors.forename: D B
authors.initials: DB
authors.lastname: Cook
authors.forename: B K
authors.initials: BK
authors.lastname: Shenton
authors.forename: A B
authors.initials: AB
authors.lastname: Griffiths
authors.forename: C D M
authors.initials: CD
authors.lastname: Griffith
authors.forename: R D
authors.initials: RD
authors.lastname: Bliss
authors.forename: T W J
authors.initials: TW
authors.lastname: Lennard
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000735:Androstenedione / Q000097:blood*; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000097:blood* / Q000378:metabolism*; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause
chemical_list: D000735:Androstenedione; D019314:Dehydroepiandrosterone Sulfate