Motor coordination in mice with hotfoot, Lurcher, and double mutations of the Grid2 gene encoding the delta-2 excitatory amino acid receptor.
Grid2(ho/ho) is a loss of function gene mutation resulting in abnormal dendritic arborizations of Purkinje cells. These mutants were compared in a series of motor coordination tests requiring balance and equilibrium to nonataxic controls (Grid2(ho/+)) and to a double mutant (Grid2(ho/Lc)) with an inserted Lc mutation. The performance of Grid2(ho/ho) mutant mice was poorer than that of controls on stationary beam, coat hanger, unsteady platform, and rotorod tests. Grid2(ho/Lc) did not differ from Grid2(Lc/+) mice. However, the insertion of the Lc mutation in Grid2(ho/Lc) potentiated the deficits found in Grid2(ho/ho) in stationary beam, unsteady platform, and rotorod tests. These results indicate a deleterious effect of the Lc mutation on Grid2-deficient mice.
Lalonde
R
R
Faculté de Médecine et de Pharmacie, Université de Rouen, 22 bld Gambetta, Bâtiment de Recherche, EMI-INSERM 9906, IFRMP 23, 76183 Rouen, France. lalonde@epeire.univ-rouen.fr
Hayzoun
K
K
Selimi
F
F
Mariani
J
J
Strazielle
C
C
D000483:Alleles; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001835:Body Weight / Q000235:genetics; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D008818:Mice, Neurologic Mutants / Q000002:abnormalities* / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time; D017470:Receptors, Glutamate / Q000235:genetics / Q000502:physiology*; D016138:Walking / Q000502:physiology
D017470:Receptors, Glutamate; C107913:glutamate receptor delta 2