Historical background for the maternal PKU syndrome.
OBJECTIVE
To provide information on the history of maternal phenylketonuria.


METHODS
A review of the literature and personal observations were conducted.


RESULTS
Compilation of sequential information about the development of our understanding of maternal PKU was produced.


CONCLUSIONS
The history of maternal PKU reflects continuous additions to our understanding of this teratogenic syndrome.
Levy
Harvey L
HL
Division of Genetics, Children's Hospital Boston, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA. harvey.levy@tch.harvard.edu
D002648:Child; D005314:Embryonic and Fetal Development; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology / Q000266:history; D006330:Heart Defects, Congenital / Q000209:etiology / Q000266:history; D049673:History, 20th Century; D006801:Humans; D008607:Intellectual Disability / Q000209:etiology / Q000266:history*; D008831:Microcephaly / Q000209:etiology / Q000266:history; D017042:Phenylketonuria, Maternal / Q000150:complications / Q000178:diet therapy / Q000266:history*; D011247:Pregnancy