title: Histamine and epidermal growth factor in women with fibrocystic changes of the breast.
abstract: In this study, the blood serum concentrations of histamine (HA) and epidermal growth factor (EGF) of women with fibrocystic changes (FCCs) of the breast were estimated. The control group comprised 32 women (mean age 44.9+/-4.4 years) without any pathologic changes in their breasts. The study group was made up of 81 women (mean age 44.5+/-3.5 years) with FCCs. The changes were divided into three subtypes: fibrous, cystic, and fibrocystic. In women with FCCs the concentrations of HA (P<0.01) and EGF (P<0.01) were significantly higher than in women without any changes in their breasts (control group). The concentration of EGF in blood serum was significantly higher in women with the fibrocystic subtype of FCC (P<0.001) than in healthy women. No correlations between the blood serum concentrations of HA and of EGF were found in either the control group or the study group. The significantly higher blood serum concentrations of HA and EGF women with FCCs than in healthy women suggest that HA and EGF have a role in the development of this disease.
authors.affiliation: Department of Menopause and Andropause, Pomeranian Academy of Medicine, Unii Lubelskiej 1 Street, 71-274 Szczecin, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Sieja
authors.forename: S
authors.initials: S
authors.lastname: Stanosz
authors.forename: N
authors.initials: N
authors.lastname: Glowińska
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001707:Biopsy, Needle; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D004815:Epidermal Growth Factor / Q000032:analysis / Q000097:blood*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000097:blood* / Q000473:pathology*; D006632:Histamine / Q000032:analysis / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D011336:Probability; D011379:Prognosis; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D004815:Epidermal Growth Factor; D006632:Histamine