No replication of the association between the Nicastrin gene and familial early-onset Alzheimer's disease.
Polymorphisms in the Nicastrin (NCSTN) gene have recently been associated with familial early-onset Alzheimer's disease (AD). The authors genotyped four NCTSN polymorphisms in a large cohort of 489 AD cases (including 158 sporadic early-onset AD cases and 95 familial early-onset AD cases) and 386 controls but failed to replicate the association between NCSTN haplotype B and AD.
Cousin
Emmanuelle
E
Aventis Pharma, Evry Genetics Center and Neurodegenerative disease group, Paris Research Center, 13 Quai Jules Guesde, 94400 Vitry-sur-Seine, France.
Hannequin
Didier
D
Macé
Sandrine
S
Dubois
Bruno
B
Ricard
Sylvain
S
Génin
Emmanuelle
E
Brun
Christophe
C
Chansac
Céline
C
Pradier
Laurent
L
Frebourg
Thierry
T
Brice
Alexis
A
Campion
Dominique
D
Deleuze
Jean-François
JF
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D053829:Amyloid Precursor Protein Secretases; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D005602:France; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D008562:Membrane Glycoproteins; C413604:nicastrin protein; D053829:Amyloid Precursor Protein Secretases