Relationships between S-100 protein-positive cells and clinicopathological factors in patients with colorectal cancer.
BACKGROUND
An increased number of dendritic cells (DCs), as indicated by positive S-100 protein staining, has been shown to correlate with good prognosis in several malignancies. The clinicopathological significance of S-100 protein-positive cells in human colorectal cancer is unclear and was thus examined.


METHODS
We investigated the relationships between the density of S-100 protein-positive cells at the peripheral area of the tumor, prognosis and clinicopathological factors in 30 patients with colorectal cancer. S-100 protein-positive cells were detected by immunohistochemistry using a mouse monoclonal antibody against S-100 protein.


RESULTS
The number of S-100 protein-positive cells was significantly higher in patients with a good prognosis or those without recurrence or worsening of their condition, but was significantly lower in patients with lymph node metastasis, T3-T4, hepatic metastasis or tumors more advanced than stage III (TNM).


CONCLUSIONS
S-100 protein-positive cells may act as one line of defense against malignant cells in patients with colorectal cancer.
Nakayama
Yoshifumi
Y
Department of Surgery 1, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi-ku, Kita-kyushu 807-8555, Japan.
Inoue
Yuzuru
Y
Minagawa
Noritaka
N
Katsuki
Takefumi
T
Nagashima
Nobuo
N
Onitsuka
Koji
K
Tsurudome
Yosuke
Y
Sako
Tatsuhiko
T
Hirata
Keiji
K
Nagata
Naoki
N
Itoh
Hideaki
H
D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000276:immunology / Q000378:metabolism*
D009418:S100 Proteins