title: A novel HLA-A allele: A*0257.
abstract: A novel human leucocyte antigen-A*02 (HLA-A*02) allele was detected by reference strand-mediated conformation analysis (RSCA) of a DNA sample from a Tarahumara individual. Direct sequencing of HLA-A locus polymerase chain reaction products identified a mutation in one of the alleles. Cloning and sequencing confirmed the presence of a new allele, A*0257 which differed from A*0206 by two nucleotides at positions 355 and 362, inducing changes in residues 95 and 97, respectively, within the peptide-binding site. Those changes suggest that allele A*0257 may have resulted from an intralocus recombination event.
authors.affiliation: Departamento de Inmunobiología Molecular, Centro de Investigación Biomédica, Facultad de Medicina, Universidad Autónoma de Coahuila, Torreón, Coahuila, México.
authors.forename: J E
authors.initials: JE
authors.lastname: García-Ortiz
authors.forename: S T
authors.initials: ST
authors.lastname: Cox
authors.forename: L
authors.initials: L
authors.lastname: Sandoval-Ramirez
authors.forename: A M
authors.initials: AM
authors.lastname: Little
authors.forename: S G E
authors.initials: SG
authors.lastname: Marsh
authors.forename: J A
authors.initials: JA
authors.lastname: Madrigal
authors.forename: J R
authors.initials: JR
authors.lastname: Argüello
mesh_terms: D000483:Alleles; D001483:Base Sequence; D015234:HLA-A Antigens / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA
chemical_list: D015234:HLA-A Antigens