Chronomics: circadian and circaseptan timing of radiotherapy, drugs, calories, perhaps nutriceuticals and beyond.
We suggest a putative benefit from timing nutriceuticals (substances that are both nutrients and pharmaceuticals) such as antioxidants for preventive or curative health care, based on the proven merits of timing nutrients, drugs, and other treatments, as documented, i.a., in India. The necessity of timing melatonin, a major antioxidant, is noted. A protocol to extend the scope of chronoradiotherapy awaits testing. Imaging in time by mapping rhythms and broader time structures, chronomes, for earliest diagnoses, for example detection of vascular disease risk, is recommended. The study of rhythms and broader chronomes leads to a dynamic functional genomics, guided by imaging in time of free radicals and antioxidants, amongst many other variables.
Halberg
Franz
F
University of Minnesota, Minneapolis, MN, USA.
Cornélissen
Germaine
G
Wang
Zhengrong
Z
Wan
Chaomin
C
Ulmer
Waldemar
W
Katinas
George
G
Singh
Ranjana
R
Singh
R K
RK
Singh
Rajesh Kumar
RK
Gupta
B D
BD
Singh
R B
RB
Kumar
Adarsh
A
Kanabrocki
Eugene
E
Sothern
Robert B
RB
Rao
Gundu
G
Bhatt
Madan L B
ML
Srivastava
Madhu
M
Rai
Gulshan
G
Singh
Subhash
S
Pati
Atanu Kumar
AK
Nath
Panchanan
P
Halberg
Francine
F
Halberg
Julia
J
Schwartzkopff
Othild
O
Bakken
Earl
E
Governor Shri Vishnu Kant Shastri
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002909:Chronobiology Phenomena / Q000502:physiology*; D019454:Chronotherapy / Q000379:methods; D002940:Circadian Rhythm / Q000502:physiology*; D002149:Energy Intake / Q000502:physiology*; D006801:Humans; D008550:Melatonin / Q000502:physiology; D009747:Nutritional Physiological Phenomena / Q000502:physiology*; D018714:Radiotherapy, Adjuvant
D000970:Antineoplastic Agents; D008550:Melatonin