[Biochemical pharmacological effects of lurongjing on young or old mice].
OBJECTIVE
To investigate the effect of Lurongjing (LRJ) on young or old mice.


METHODS
In vivo monoamine oxidase (MAO) and superoxide dismutase(SOD) activities, the contents of monoamines(5-HT, NE, DA), malondialdehyde (MDA), RNA and protein, and the incorporations of [3H] Uridine into RNA and [3H] Leucine into protein in liver tissue were measured.


RESULTS
The inhibition of MAO-B activity and the increase of monoamines(5-HT, DA) level, the increase of RNA and protein level, and the incorporations of [3H] Uridine into RNA and [3H] Leucine into protein in liver tissue, the enhancement of SOD activity and the decrease of MDA content in brain and liver tissues were selectively observed in old mice(24 months) than in young mice(1 month) by LRJ (i.g., 4.0 g/kg) administrated orally for 10 successive days.


CONCLUSIONS
LRJ exhibits some anti-aging effect in old mice.
Wang
Yan
Y
First Affiliated Hospital, Jilin University, Changchun 130021.
Chen
Xiaoguang
X
D000375:Aging / Q000187:drug effects*; D000818:Animals; D001921:Brain / Q000378:metabolism; D003670:Deer; D005260:Female; D006733:Horns / Q000737:chemistry*; D008099:Liver / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
D008419:Materia Medica; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D008995:Monoamine Oxidase