Cytotoxic cucurbitacin constituents from Sloanea zuliaensis.
A new cucurbitacin D analogue, 2-deoxycucurbitacin D (1), as well as cucurbitacin D (2) and 25-acetylcucurbitacin F (3) were isolated from Sloanea zuliaensis. Compound 1 was found only in the young leaves of the plant and not in the mature leaves, and its structure was established using spectroscopic means. Compounds 1-3 demonstrated potent cytotoxic activity against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines.
Rodriguez
Nelson
N
Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Apartado 10767, Estafeta Universitaria, Panamá, República de Panamá.
Vasquez
Yelkaira
Y
Hussein
Ahmed A
AA
Coley
Phyllis D
PD
Solis
Pablo N
PN
Gupta
Mahabir P
MP
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001943:Breast Neoplasms; D016543:Central Nervous System Neoplasms; D004354:Drug Screening Assays, Antitumor; D045467:Elaeocarpaceae / Q000737:chemistry*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms; D015394:Molecular Structure; D010176:Panama; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
C482490:2-deoxycucurbitacin D; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C038105:cucurbitacin D