Cellular consequences of transthyretin deposition.
Mutant forms of transthyretin (TTR) deposit in tissues of patients presenting with familial amyloidotic polyneuropathy (FAP). The cellular consequences of tissue TTR deposition have only been addressed recently and are summarized here. Inflammatory and oxidative stress pathways are triggered by fibrillar and non-fibrillar TTR deposits, a fact to take into account in future forms of FAP treatment.
Saraiva
Maria J
MJ
Instituto de Biologia Molecular e Celular, Instituto de Ci ncias Biom dicas Abel Salazar, University of Porto, Portugal. mjsaraiv@ibmc.up.pt
D028227:Amyloid Neuropathies, Familial / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D017209:Apoptosis; D002478:Cells, Cultured; D006801:Humans; D026561:Low Density Lipoprotein Receptor-Related Protein-2 / Q000378:metabolism*; D051379:Mice; D009154:Mutation; D009474:Neurons / Q000378:metabolism* / Q000648:ultrastructure; D009569:Nitric Oxide / Q000378:metabolism; D011228:Prealbumin / Q000378:metabolism*; D051381:Rats
D026561:Low Density Lipoprotein Receptor-Related Protein-2; D011228:Prealbumin; D009569:Nitric Oxide