title: Synthesis and biological evaluation of ebselen and its acyclic derivatives.
abstract: Five ebselen and three acyclic ebselen derivatives were synthesized. These compounds were screened for their glutathione peroxidase (GSH Px)-like activity and scavenging activity against 1,1-diphenyl-2-pycryl-hydrazyl (DPPH) and peroxynitrite radical. All tested compounds displayed similar significant GSH Px-like activity, which are slightly higher than that of ebselen. The peroxynitrite scavenging activity showed that the acyclic allylseleno 4c was five times more potent than ebselen.
authors.affiliation: Department of Biochemistry, National Defense Medical Center, Neihu, Taipei, Taiwan, ROC.
authors.forename: Tsu-Chung
authors.initials: TC
authors.lastname: Chang
authors.forename: Mei-Lan
authors.initials: ML
authors.lastname: Huang
authors.forename: Wen-Lin
authors.initials: WL
authors.lastname: Hsu
authors.forename: Jing-Min
authors.initials: JM
authors.lastname: Hwang
authors.forename: Ling-Yih
authors.initials: LY
authors.lastname: Hsu
mesh_terms: D001393:Azoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000494:pharmacology; D006839:Hydrocarbons, Acyclic / Q000138:chemical synthesis / Q000494:pharmacology; D054833:Isoindoles; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D001393:Azoles; D016166:Free Radical Scavengers; D006839:Hydrocarbons, Acyclic; D054833:Isoindoles; D016566:Organoselenium Compounds; C042986:ebselen