Proteolytic processing in development and leukemogenesis.
There are now numerous examples in the hematopoietic system of genes that are critical for normal hematopoietic development, but when mutated, rearranged, or overexpressed, contribute to leukemogenesis. Two papers in this issue of Cell provide a fascinating twist on this paradigm, and suggest that proteolytic processing of certain of these genes plays an important role both in development and in leukemogenesis. These findings also suggest the possibility that proteases may be therapeutic targets in leukemia.
Gilliland
D Gary
DG
Howard Hughes Medical Institute, Harvard Medical School, Harvard Institutes of Medicine, 4 Blackfan Circle, Room 418, 02115, Boston, MA, USA
D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism*; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D011495:Histone-Lysine N-Methyltransferase; D018398:Homeodomain Proteins / Q000235:genetics; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D019272:Leukocyte Elastase / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D051788:Myeloid-Lymphoid Leukemia Protein; D009363:Neoplasm Proteins / Q000737:chemistry / Q000378:metabolism*; D015514:Oncogene Proteins, Fusion / Q000737:chemistry / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D011519:Proto-Oncogenes; D013912:Threonine / Q000378:metabolism*; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; C497422:KMT2A protein, human; D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; D014157:Transcription Factors; C093476:promyelocytic leukemia-retinoic acid receptor alpha fusion oncoprotein; D051788:Myeloid-Lymphoid Leukemia Protein; D013912:Threonine; D011495:Histone-Lysine N-Methyltransferase; C497423:Kmt2a protein, mouse; D010450:Endopeptidases; D019272:Leukocyte Elastase