title: Non-treatment-related chronic myeloid leukemia as a second malignancy.
abstract: The characteristics of the very rare non-treatment-related chronic myeloid leukemia (nTr-CML) cases have never before been analyzed. The literature up to December 2002 was screened using the Medline database to identify cases of Tr-CML and nTr-CML. We considered five cases with nTr-CML identified among 270 newly diagnosed CML at our Department. Our report thus considers nine cases with nTr-CML compared to 77 affected by Tr-CML as a secondary neoplasm. The median age at the appearance of the first tumor was higher in nTr-CML patients compared to that of the Tr-CML group (P<0.0001). The median age at CML diagnosis was significantly higher in the nTr-CML than in the Tr-CML group (P<0.0001). The proportion of hematological malignancies as first tumor type was not different in the two groups (44% in nTr-CML versus 56% in Tr-CML). Our study underlines that nTr-CML as a second malignancy is a rare entity associated with elderly age.
authors.affiliation: Department of Haematology, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy. emadhba@cimedoc.uniba.it
authors.forename: Giorgina
authors.initials: G
authors.lastname: Specchia
authors.forename: Caterina
authors.initials: C
authors.lastname: Buquicchio
authors.forename: Francesco
authors.initials: F
authors.lastname: Albano
authors.forename: Arcangelo
authors.initials: A
authors.lastname: Liso
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pannunzio
authors.forename: Anna
authors.initials: A
authors.lastname: Mestice
authors.forename: Rita
authors.initials: R
authors.lastname: Rizzi
authors.forename: Domenico
authors.initials: D
authors.lastname: Pastore
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Liso
mesh_terms: D000367:Age Factors; D000368:Aged; D005260:Female; D019337:Hematologic Neoplasms / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000453:epidemiology / Q000209:etiology*; D016239:MEDLINE; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence; D012189:Retrospective Studies