title: Linezolid penetration into bone and joint tissues infected with methicillin-resistant staphylococci.
abstract: Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of 35 to 124 min after administration of the preoperative dose, except in bone specimens, where they reached 3.9 +/- 2.0 mg/liter.
authors.affiliation: Department of Surgery-Trauma Center, BG Kliniken Bergmannsheil-Universitätsklinik, Ruhr University, Bochum, Germany. Friedrich.Kutscha-Lissberg@ruhr-uni-bochum.de
authors.forename: Friedrich
authors.initials: F
authors.lastname: Kutscha-Lissberg
authors.forename: Ute
authors.initials: U
authors.lastname: Hebler
authors.forename: Gert
authors.initials: G
authors.lastname: Muhr
authors.forename: Manfred
authors.initials: M
authors.lastname: Köller
mesh_terms: D000081:Acetamides / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001842:Bone and Bones / Q000378:metabolism*; D003646:Debridement; D005260:Female; D006801:Humans; D007596:Joints / Q000378:metabolism*; D000069349:Linezolid; D008297:Male; D016106:Methicillin Resistance; D008875:Middle Aged; D009336:Necrosis; D023303:Oxazolidinones / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid