title: Urinary metabolites of nobiletin orally administered to rats.
abstract: During the course of our systematic investigation of the metabolism of flavonoids, the polymethoxyflavone nobiletin, occurring in the fruits of Citrus depressa, was orally administered to rats. The urinary metabolites were separated and identified by three-dimensional HPLC equipped with a photodiode array detector and the structure was determined by spectroscopic methods to be 4'-hydroxy-3',5,6,7,8-pentamethoxyflavone (1).
authors.affiliation: Department of Phytochemistry, Tohoku Pharmaceutical University, Sendai, Miyagi, Japan.
authors.forename: Takaaki
authors.initials: T
authors.lastname: Yasuda
authors.forename: Yukako
authors.initials: Y
authors.lastname: Yoshimura
authors.forename: Hisako
authors.initials: H
authors.lastname: Yabuki
authors.forename: Takahiro
authors.initials: T
authors.lastname: Nakazawa
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ohsawa
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Mimaki
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sashida
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001711:Biotransformation; D047309:Flavones; D005419:Flavonoids / Q000008:administration & dosage* / Q000737:chemistry / Q000652:urine*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D047309:Flavones; D005419:Flavonoids; C008661:nobiletin