Mitotic mechanics: the auroras come into view.
Aurora kinases have recently taken centre stage in the regulation of key cell cycle processes. Aurora A is emerging as a critical regulator of centrosome and spindle function. Aurora B mediates chromosome segregation by ensuring proper biorientation of sister chromatids, possibly through the regulation of microtubule dynamics. This enzyme also functions in cytokinesis apparently by interacting with a critical GTPase and a kinesin-like protein. Recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division.
Andrews
Paul D
PD
Division of Gene Expression and Regulation, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK.
Knatko
Elena
E
Moore
William J
WJ
Swedlow
Jason R
JR
D000818:Animals; D064107:Aurora Kinase B; D064127:Aurora Kinases; D018797:Cell Cycle Proteins; D002455:Cell Division; D002842:Chromatids / Q000737:chemistry; D002843:Chromatin / Q000378:metabolism; D004330:Drosophila; D006004:Glycogen Debranching Enzyme System / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D008856:Microscopy, Fluorescence; D008870:Microtubules; D008938:Mitosis; D008954:Models, Biological; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D014981:Xenopus; D029867:Xenopus Proteins
D018797:Cell Cycle Proteins; D002843:Chromatin; D006004:Glycogen Debranching Enzyme System; D029867:Xenopus Proteins; C020569:4 alpha-glucanotransferase; D011494:Protein Kinases; C112134:AURKA protein, Xenopus; C576921:AURKB protein, human; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases