title: [Selective pharyngeal brain cooling].
abstract: Whole-body cooling can be used in the treatment of various brain pathologies, for example, after hypoxic events. Potential complications include haemodynamic instability, coagulation disorders and infection. Selective brain cooling (SBC) would therefore appear to make good sense. In an animal model a new approach to SBC was therefore evaluated. A rat weighing 350 g was sedated with alpha-chloralose (40 mg/kg/h) and d-tubocurarine (4.05 mg/kg/h), mechanically ventilated and placed on a heating pad. A thermocouple was introduced into the somatosensory cortex to a depth of 2.5 mm. SBC was achieved using a novel approach: PTFE tubing (ID 100 microns) with an inlet and an outlet was wrapped around and glued to a piece of wood, and introduced non traumatically into the pharynx. The tubing was perfused with cold water (+4 degrees C). Under SBC the cortical temperature dropped from 38.4 degrees C to 27.7 degrees C while the core temperature remained stable. In an animal model SBC was successfully accomplished via the pharynx. Further studies should now be done to evaluate the effectiveness of this approach in larger animals with potentially different anatomical features.
authors.affiliation: Dept. of Radiology and Neurology, Yale University, New Haven, CT 06520, USA. hubert.trubel@yale.edu
authors.forename: H
authors.initials: H
authors.lastname: Trübel
authors.forename: P
authors.initials: P
authors.lastname: Herman
authors.forename: C
authors.initials: C
authors.lastname: Kampmann
authors.forename: E
authors.initials: E
authors.lastname: Novotny
authors.forename: F
authors.initials: F
authors.lastname: Hyder
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000528:radiation effects*; D001927:Brain Diseases / Q000628:therapy; D002404:Catheterization / Q000295:instrumentation / Q000379:methods; D003080:Cold Temperature; D017679:Cryotherapy / Q000379:methods; D007036:Hypothermia, Induced / Q000295:instrumentation* / Q000379:methods*; D010614:Pharynx / Q000502:physiology* / Q000528:radiation effects*; D051381:Rats; D012680:Sensitivity and Specificity; D013003:Somatosensory Cortex / Q000502:physiology* / Q000528:radiation effects*