[Thoracic nocardiasis associated with macrophage activation syndrome].
Nocardiasis is an uncommon bacterial disease often observed in immunodepressed patients. Its interactions with the immune system remain poorly known. We report a case of Nocardia asteroides thoracic nocaridiasis in an African subject who also had macrophage activation syndrome. We recall the classic data on nocardiasis in Africa and emphasize the importance of emergence in HIV-infected subjects. The association between nocardiasis and macrophage activation syndrome suggest a possible pathogenic mechanism involving the immune system (lymphocytes and macrophages) and Nocardia asteroides.
Simon
F
F
Service de Pneumologie, Hôpital d'Instruction des Armées Percy, BP 01, 00480 Armées, France.
Koninck
J C
JC
Vaylet
F
F
Samson
T
T
Falque
L
L
Herve
V
V
Ayar
M
M
Le Vagueresse
R
R
Crevon
T
T
L'Her
P
P
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D000583:Amikacin / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D001706:Biopsy; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology; D002443:Ceftriaxone / Q000627:therapeutic use; D003937:Diagnosis, Differential; D018432:Drug Resistance, Multiple; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D015616:Histiocytosis, Non-Langerhans-Cell / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D008168:Lung / Q000276:immunology / Q000473:pathology; D008262:Macrophage Activation / Q000187:drug effects / Q000276:immunology*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009617:Nocardia Infections / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D009616:Nocardia asteroides / Q000187:drug effects / Q000276:immunology*; D018410:Pneumonia, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D012008:Recurrence; D013583:Synovial Membrane / Q000276:immunology / Q000473:pathology; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D014057:Tomography, X-Ray Computed
D002443:Ceftriaxone; D000583:Amikacin