title: Results of a new serologic test suggest an association of Waddlia chondrophila with bovine abortion.
abstract: Waddlia chondrophila is a little-known intracellular organism belonging to the order Chlamydiales that has twice been isolated from aborted bovine fetuses. To initiate an investigation of the possibility that W. chondrophila may be an abortifacient pathogen, a serologic test was developed and used to screen bovine sera that were submitted to the Washington Animal Disease Diagnostic Laboratory (Pullman, WA). A highly significant statistical association (P < 0.00001) was observed when comparing antibody titers in cows that had aborted with those in other classes of cattle. Although this result is consistent with the possibility that infection with W. chondrophila may be a cause of bovine abortion, it is also possible that seroprevalence simply increases with age or that exposure rates differ between cows and other classes of cattle. Future serologic studies should specifically compare antibody titers between aborting cows and carefully matched nonaborting cohorts.
authors.affiliation: Washington Animal Disease Diagnostic Laboratory, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA.
authors.forename: Pam
authors.initials: P
authors.lastname: Dilbeck-Robertson
authors.forename: Milton M
authors.initials: MM
authors.lastname: McAllister
authors.forename: Dan
authors.initials: D
authors.lastname: Bradway
authors.forename: James F
authors.initials: JF
authors.lastname: Evermann
mesh_terms: D000034:Abortion, Veterinary / Q000382:microbiology*; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology*; D002695:Chlamydiales / Q000472:pathogenicity*; D005260:Female; D016036:Seroepidemiologic Studies; D012698:Serologic Tests / Q000662:veterinary
chemical_list: D000907:Antibodies, Bacterial