Cell death in the nasal septum of normal and naris-occluded rats.
Blocking airflow through an external naris of a newborn rat results in a thinning of the olfactory mucosa by postnatal day (P) 20, at least partially due to a reduction in mitotic rates. We employed the TUNEL method to examine patterns of cell death. By P20-30, significant differences in the numbers of labeled profiles were found in the middle 50% of the tissue, a region primarily containing olfactory sensory cells.
Brunjes
Peter
P
Department of Psychology, University of Virginia, 102 Gilmer Hall Box 400400, Charlottesville, VA 22904-4400, USA. brunjes@virginia.edu
Shurling
Dixie C
DC
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002425:Cautery / Q000379:methods; D016923:Cell Death; D007839:Functional Laterality; D020287:In Situ Nick-End Labeling / Q000379:methods; D015508:Nasal Obstruction / Q000473:pathology* / Q000503:physiopathology; D009300:Nasal Septum / Q000254:growth & development / Q000473:pathology*; D009831:Olfactory Mucosa / Q000378:metabolism; D051381:Rats; D020318:Rats, Long-Evans; D018709:Statistics, Nonparametric