title: [Randomized controlled clinical study on effect of Chinese compound changjitai in treating diarrheic irritable bowel syndrome].
abstract: OBJECTIVE
  To verify the clinical efficacy and safety of the proven Chinese Compound Changjitai (CJT), in treating the diarrheic irritable bowel syndrome (DIBS).
  
  
  METHODS
  Randomized controlled open clinical trial design was adopted, 45 patients were randomly divided into two groups, CJT and pinaverium bromide (PVB) were given as treated and control agent respectively. IBS scoring system (BSS), defecation state questionnaire (DSQ) were used to record the changes of the patients' main symptoms before and after treatment.
  
  
  RESULTS
  The total effective rate of CJT group was 83.3%, while that of PVB was 73.3%. CJT was superior in efficacy to that of PVB in improving stool quality, reducing defecation episodes of diarrheic patients, alleviating tenesmus symptoms, decreasing bellyache days and ameliorating abdominal distention. Any drug-related adverse reaction was not seen.
  
  
  CONCLUSIONS
  The efficacy of CJT in treating DIBS is definite and without any toxic and adverse effects.
authors.affiliation: Shanghai University of TCM, Shanghai 200032. shnyun51@163.com
authors.forename: Yun
authors.initials: Y
authors.lastname: Shen
authors.forename: Gan
authors.initials: G
authors.lastname: Cai
authors.forename: Xu
authors.initials: X
authors.lastname: Sun
mesh_terms: D000328:Adult; D003967:Diarrhea / Q000188:drug therapy / Q000209:etiology; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000627:therapeutic use; D008517:Phytotherapy
chemical_list: D004365:Drugs, Chinese Herbal; D009025:Morpholines; C013199:pinaverium