Rapidly progressive parkinsonism in a self-reported user of ecstasy and other drugs.
A 38-year-old man developed parkinsonism that progressed to Hoehn and Yahr stage 5 within 4 years of onset. Response to ropinirole deteriorated, levodopa was not tolerated, and subthalamic nucleus stimulation has provided only partial relief of symptoms. He reported heavy use of Ecstasy through most of his twenties and thirties. His neurological problems may be unrelated to his drug use, but it is also possible they represent an idiosyncratic reaction.
O'Suilleabhain
Padraig
P
Department of Neurology, University of Texas Southwestern Medical School, Dallas, Texas, USA.
Giller
Cole
C
D000328:Adult; D000978:Antiparkinson Agents / Q000627:therapeutic use; D018450:Disease Progression; D006213:Hallucinogens / Q000009:adverse effects*; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D007211:Indoles / Q000627:therapeutic use; D008297:Male; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000009:adverse effects*; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000209:etiology*; D012650:Self Disclosure; D019966:Substance-Related Disorders / Q000150:complications*; D013997:Time Factors
D000978:Antiparkinson Agents; D006213:Hallucinogens; D007211:Indoles; C046649:ropinirole; D018817:N-Methyl-3,4-methylenedioxyamphetamine