Syndecan-2 expression enhances adhesion and proliferation of stably transfected Swiss 3T3 cells.
Syndecans (heparan sulfate proteoglycans) participate in cell-cell and cell-matrix adhesion and are co- and low-affinity receptors for growth factors and enzymes, respectively. We examined the influence of stable syndecan-2 expression in Swiss 3T3 cells on cell-adhesion and proliferation. Higher syndecan-2 expression changed cell morphology and increased spreading and adhesion in these cells and proliferation induced by FCS and FGF-2. This emphasizes the role of syndecan-2 in the integration of signals from soluble and insoluble factors.
Villena
Joan
J
Department of Cellular Biology, Faculty of Biology, University of Barcelona, Diagonal 645, Catalunya, Barcelona 08028, Spain. jvilena@porthos.bio.ub.es
Berndt
Christine
C
Granés
Francesc
F
Reina
Manuel
M
Vilaró
Senén
S
D000818:Animals; D015153:Blotting, Western; D002448:Cell Adhesion; D002455:Cell Division; D018076:DNA, Complementary / Q000378:metabolism; D003720:Densitometry; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000502:physiology*; D051379:Mice; D011509:Proteoglycans / Q000096:biosynthesis* / Q000502:physiology*; D041701:Swiss 3T3 Cells; D053669:Syndecan-2; D013997:Time Factors; D014162:Transfection
D018076:DNA, Complementary; D008562:Membrane Glycoproteins; D011509:Proteoglycans; C508246:Sdc2 protein, mouse; D016222:Fibroblast Growth Factor 2; D053669:Syndecan-2