Recovery of renal function after long-term dialysis in hemolytic uremic syndrome.
Long-lasting recovery of renal function of the native kidneys after prolonged renal replacement therapy is rare. An 8-year-old girl and a 3-year-old boy had suffered from acute atypical and diarrhea-associated hemolytic uremic syndrome (HUS), respectively, with subsequent apparent end-stage renal failure. Both recovered renal function after long-lasting anuria and dialysis of 8 and 16 months, respectively. After prolonged follow-up, i.e., 7 and 5 years after cessation of dialysis, they attained normal or slightly reduced renal function (plasma creatinine 84 and 90 micro mol/l, respectively). In addition, growth and cognitive development were normal. We conclude that caution is appropriate before offering early renal transplantation to pediatric patients with presumed end-stage kidney disease secondary to HUS.
Brunner
Kathrin
K
Division of Pediatric Nephrology, University of Bern, Bern, Switzerland.
Bianchetti
Mario G
MG
Neuhaus
Thomas J
TJ
D002648:Child; D002675:Child, Preschool; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D020127:Recovery of Function; D006435:Renal Dialysis; D013997:Time Factors