title: Clinical effectiveness of antibiotic-impregnated cement spacers for the treatment of infected implants of the hip joint.
abstract: It is difficult to treat an infected implant of the hip joints, as it requires long-term treatment and eventually may lead to amputation or arthrodesis, involving immeasurable physical and psychological suffering for the patient. We utilized antibiotic-impregnated cement spacers for 17 infections after total hip arthroplasty and bipolar arthroplasty with good clinical results. We thoroughly removed any foreign material and formed an antibiotic-impregnated cement spacer into a shape similar to that of the implants. This enabled high-concentration antibiotics to act on the infected sites. It also can prevent leg-length discrepancy and atrophy of bones or muscles. Although cement spacers have been reported to have problems regarding shape and strength, we achieved good results with cement spacer molds in the present study. All revision surgeries were performed using a two-stage procedure. No infection has recurred at a mean follow-up of 3 years 2 months.
authors.affiliation: Department of Orthopedic Surgery, Tokyo Medical University, 6-7-1 Nishi-shinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
authors.forename: Kengo
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Naoki
authors.initials: N
authors.lastname: Miyagawa
authors.forename: Toshinori
authors.initials: T
authors.lastname: Masaoka
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Katori
authors.forename: Takaaki
authors.initials: T
authors.lastname: Shishido
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Imakiire
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects* / Q000379:methods; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D001843:Bone Cements; D004343:Drug Implants; D005260:Female; D005500:Follow-Up Studies; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000302:isolation & purification; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology; D012189:Retrospective Studies; D018570:Risk Assessment; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D001843:Bone Cements; D004343:Drug Implants