Effect of Bu-zhong-yi-qi-tang on seminal plasma cytokine levels in patients with idiopathic male infertility.
Twenty-two idiopathic infertile patients were treated with Oriental herbal medicine, Bu-zhong-yi-qi-tang (Hochu-ekki-to). Seminal plasma sFas level elevated significantly after herb administration. There was an inverse correlation between seminal plasma IL-6 level and sperm concentration before treatment. After the administration of herb seminal plasma, sFas levels significantly correlated with sperm concentration. Seminal plasma IL-8 level did not change. Certain kinds of cytokine in the seminal plasma might play some role in improving semen quality with treatment.
Furuya
Y
Y
Department of Urology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama 930-0194, Japan. furuyayu@ms.toyama-mpu.ac.jp
Akashi
T
T
Fuse
H
H
D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D016209:Interleukin-8 / Q000378:metabolism; D008297:Male; D009845:Oligospermia / Q000188:drug therapy*; D012661:Semen / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D019014:fas Receptor / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D015850:Interleukin-6; D016209:Interleukin-8; C402943:bu-zhong-yi-qi-tang; D019014:fas Receptor