Isolation, structure elucidation and biological activities of trichofumins A, B, C and D, new 11 and 13mer peptaibols from Trichoderma sp. HKI 0276W.
Trichofumins A-D were isolated from cultures of Trichoderma sp. HKI 0276 as new 11 and 13mer peptaibols. Similar to 15mer peptaibols they promote morphogenesis of the fungus Phoma destructiva and cause hypothermia in mice as a characteristic of neuroleptic activity. Membrane measurements using a synthetic BLM model showed that A, B, C and D increased membrane permeability for cations in a similar manner as was shown for larger peptaibols but with comparably lower efficiency.
Berg
Albrecht
A
Hans-Knöll-Institute for Natural Products Research, Beutenbergstrasse 11a, D-07745 Jena, Germany. aberg@pmail.hki-Jena.de
Grigoriev
Pavel A
PA
Degenkolb
Thomas
T
Neuhof
Torsten
T
Härtl
Albert
A
Schlegel
Brigitte
B
Gräfe
Udo
U
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D004594:Electrophysiology; D005656:Fungal Proteins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D007035:Hypothermia / Q000139:chemically induced; D007476:Ionophores / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008051:Lipid Bilayers; D008297:Male; D051379:Mice; D009024:Morphogenesis / Q000187:drug effects; D014242:Trichoderma / Q000737:chemistry*
D005656:Fungal Proteins; D007476:Ionophores; D008051:Lipid Bilayers