title: Eruptive large melanocytic nevus in a patient with hereditary epidermolysis bullosa simplex.
abstract: Hereditary epidermolysis bullosa (HEB) is a group of genetically determined mechanobullous disorders characterized by blister formation following minor trauma. Unusual melanocytic lesions may be a rare feature of all major categories of HEB. We report a large melanocytic nevus, clinically simulating malignant melanoma, which developed at a site of healing blisters in an 8-year-old male with recessive generalized epidermolysis bullosa simplex (EBS). Histological findings were consistent with a compound nevus. This is the third reported case of an eruptive melanocytic nevus developing in EBS. Due to their unique features, it has been suggested that these nevi may represent a distinct variant, referred to as epidermolysis bullosa nevi. Despite the atypical picture, no malignant transformation of HEB nevi has been seen. Therefore, after histologic verification, regular long-term follow-up rather than radical surgery is recommended.
authors.affiliation: Department of Dermatology and Venereology, A. Sygros Hospital, National and Kapodistrian University of Athens, Athens, Greece. dr_stravianeas@hotmail.com
authors.forename: N G
authors.initials: NG
authors.lastname: Stavrianeas
authors.forename: A C
authors.initials: AC
authors.lastname: Katoulis
authors.forename: V
authors.initials: V
authors.lastname: Moussatou
authors.forename: E
authors.initials: E
authors.lastname: Bozi
authors.forename: H
authors.initials: H
authors.lastname: Petropoulou
authors.forename: C
authors.initials: C
authors.lastname: Limas
authors.forename: S
authors.initials: S
authors.lastname: Georgala
mesh_terms: D002648:Child; D016110:Epidermolysis Bullosa Simplex / Q000150:complications*; D006801:Humans; D008297:Male; D009508:Nevus, Pigmented / Q000209:etiology*