title: Isolated central nervous system (CNS) relapse in a case of childhood systemic anaplastic large cell lymphoma without initial CNS involvement.
abstract: Central nervous system (CNS) involvement in cases of anaplastic large cell lymphoma (ALCL) has been described only rarely. The authors describe an 11-year-old girl with ALCL who developed isolated CNS relapse but had no CNS disease at initial diagnosis and had received CNS-prophylactic treatment. The patient achieved a second remission following intensive treatment of the relapse and continues to be in remission at the time of writing. This case serves to emphasize that isolated CNS relapse without detectable initial CNS involvement can arise even after CNS-prophylactic treatment in pediatric ALCL cases.
authors.affiliation: Department of Pediatrics, Keio University School of Medicine, Tokyo, Japan. moreite@sc.itc.keio.ac.jp
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mori
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sugita
authors.forename: Kyoko
authors.initials: K
authors.lastname: Kimura
authors.forename: Tomoko
authors.initials: T
authors.lastname: Fuke
authors.forename: Takuma
authors.initials: T
authors.lastname: Miura
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Kiyokawa
authors.forename: Junichiro
authors.initials: J
authors.lastname: Fujimoto
mesh_terms: D016543:Central Nervous System Neoplasms / Q000473:pathology* / Q000517:prevention & control / Q000628:therapy; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000188:drug therapy / Q000473:pathology* / Q000628:therapy; D036102:Peripheral Blood Stem Cell Transplantation; D012008:Recurrence; D012074:Remission Induction / Q000379:methods; D014182:Transplantation, Autologous