Heat shock proteins (HSP) for immunotherapy of rheumatoid arthritis (RA).
Rheumatoid arthritis (RA) is an inflammatory disease that primarily involves the joints and has a worldwide prevalence of about one percent, with a female to male ratio of 3:1. This chapter summarizes some of the recent progress in molecular immunology, and discusses the application of this new knowledge for therapeutic purposes. We focus on our recent experiences and that of others in modulation of antigen specific responses as a tool for manipulating autoimmune inflammation. Particular emphasis is given to the concept of exploiting for therapeutic purposes a natural mechanism of immune regulation. This mechanism is based on sequential cross recognition of bacterial and human derived heat shock protein peptides.
Puga Yung
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Departments of Medicine and Pediatrics, University of California San Diego, 9500 Gilman Jolla, San Diego, CA 92093-0663, USA.
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Roord
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Prakken
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Albani
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D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000628:therapy*; D002986:Clinical Trials as Topic; D000939:Epitopes; D004926:Escherichia coli / Q000378:metabolism; D005260:Female; D006360:Heat-Shock Proteins / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D007249:Inflammation; D008297:Male; D008954:Models, Biological; D010455:Peptides / Q000737:chemistry; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000939:Epitopes; D006360:Heat-Shock Proteins; D010455:Peptides