title: Lactose digestion in pregnant African-Americans.
abstract: OBJECTIVE
  This paper reports on the status of lactose digestion during early and late pregnancy and at 8 weeks postpartum in an African-American population. The hypothesis is that lactose digestion and milk tolerance do not change throughout pregnancy and do not differ from those of non-pregnant African-American women.
  
  
  METHODS
  This longitudinal study determined lactose digestion after ingesting 240 ml of 1% fat milk containing 12 g of lactose at: (1) early pregnancy, prior to 16 weeks (n=148); (2) late pregnancy, 30-35 weeks (n=77); and (3) 8 weeks postpartum (n=93). One hundred and one comparably matched non-pregnant African-American women served as controls.
  
  
  RESULTS
  Prevalence of lactose digestion, as measured by breath hydrogen, was 80.2% in the control women, 66.2% in early pregnancy, 68.8% in late pregnancy and 75.3% postpartum. The prevalence of women reporting symptoms was approximately 20% regardless of lactose absorption status. However, the control women reported significantly more symptoms than did the pregnant women.
  
  
  CONCLUSIONS
  This study indicates that there is no significant change in lactose digestion during pregnancy. The prevalence of lactose intolerance for the pregnant African-American women studied is similar to that for non-pregnant African-American women and similar to previous prevalence reports in adult African-Americans. There was no change in the tolerance of lactose noted during pregnancy in these women. There were, however, fewer symptoms reported by the lactose-maldigesting pregnant women.
authors.affiliation: Department of Population and Family Health Sciences, Johns Hopkins Bloomberg School of Public Health, 624 North Broadway, Room 280, Baltimore, MD 21205, USA. dpaige@jhsph.edu
authors.forename: David M
authors.initials: DM
authors.lastname: Paige
authors.forename: Frank R
authors.initials: FR
authors.lastname: Witter
authors.forename: Yvonne L
authors.initials: YL
authors.lastname: Bronner
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Kessler
authors.forename: Jay A
authors.initials: JA
authors.lastname: Perman
authors.forename: Tara R
authors.initials: TR
authors.lastname: Paige
mesh_terms: D000046:Academic Medical Centers; D000328:Adult; D001741:Black or African American; D015142:Baltimore; D001944:Breath Tests; D004063:Digestion / Q000502:physiology*; D005260:Female; D005414:Flatulence; D006801:Humans; D006859:Hydrogen / Q000032:analysis; D007785:Lactose / Q000032:analysis / Q000378:metabolism*; D007787:Lactose Intolerance / Q000208:ethnology* / Q000503:physiopathology; D008137:Longitudinal Studies; D049590:Postpartum Period / Q000208:ethnology / Q000378:metabolism*; D011247:Pregnancy; D011264:Pregnancy Trimesters / Q000208:ethnology / Q000378:metabolism*; D013997:Time Factors
chemical_list: D006859:Hydrogen; D007785:Lactose