Solitary plasmacytoma of the mandible in a renal transplant recipient.
A solitary plasmacytoma occurring in the mandible of a 15-year-old Korean male 6 years after renal transplantation is reported. The tumour presented as a hyperplastic gingival overgrowth in the right madibular molar area. Histology and immunohistochemistry revealed plasmacytoma and monoclonality of the kappa chain and IgG. In situ hybridization for Epstein-Barr virus encoded RNA (EBER) showed positive signals in the tumour cells. The tumour regressed after reducing the immunosuppressive agents with concurrent radiotherapy. The patient remains in a stable condition with normal renal functions after 7 years without recurrence. This case confirms that Epstein-Barr virus associated B-lymphoproliferative disorders are still a major complication of immunosuppression.
Yoon
J H
JH
Department of Oral Pathology, College of Dentistry, Chosun University, Gwangju, Korea.
Yook
J I
JI
Kim
H J
HJ
Cha
I H
IH
Yang
W I
WI
Kim
J
J
D000293:Adolescent; D020031:Epstein-Barr Virus Infections / Q000209:etiology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D017403:In Situ Hybridization; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008339:Mandibular Neoplasms / Q000209:etiology* / Q000473:pathology / Q000532:radiotherapy / Q000821:virology*; D010954:Plasmacytoma / Q000209:etiology* / Q000473:pathology / Q000532:radiotherapy / Q000821:virology*
D007166:Immunosuppressive Agents