title: Motor effects of amphetamine in rats pretreated with either dizocilpine or phencyclidine.
abstract: The aim of the present study was to examine motor effects of amphetamine (AMPH) in rats pretreated with either dizocilpine (MK-801) or phencyclidine (PCP), and to estimate possible differences in these effects. Our results showed that AMPH increases the duration of motor effects of PCP, while it does not change motor effects of MK-801. These findings may reflect different mechanisms of action of MK-801 and PCP, as well as selective influence of AMPH on metabolism of these drugs.
authors.affiliation: Laboratory of Electrophysiology and Behavior, Department of Neurobiology and Immunology, Institute for Biological Research, 29 Novembra 142, 11060 Belgrade, Yugoslavia. vesnav@ibiss.bg.ac.yu
authors.forename: Vesna
authors.initials: V
authors.lastname: Pesić
authors.forename: Branka
authors.initials: B
authors.lastname: Janać
authors.forename: Desanka
authors.initials: D
authors.lastname: Milanović
authors.forename: Mirko
authors.initials: M
authors.lastname: Tomić
authors.forename: Rosica
authors.initials: R
authors.lastname: Veskov
authors.forename: Ljubisav
authors.initials: L
authors.lastname: Rakić
mesh_terms: D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004347:Drug Interactions; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009068:Movement / Q000187:drug effects; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
chemical_list: D000697:Central Nervous System Stimulants; D018691:Excitatory Amino Acid Antagonists; D016291:Dizocilpine Maleate; D000661:Amphetamine; D010622:Phencyclidine