title: Characterization of murine leukemia virus restriction in mammals.
abstract: Restriction of murine leukemia virus (MLV) was examined in cells from a range of mammals. All nonmurine restrictions were saturable blocks to N-tropic MLV infection, and several were prior to reverse transcription. We demonstrate restriction in cells from bat and show that if we express the murine restriction factor Fv1 in human cells, then Fv1, not the human host, defines the stage at which infection is blocked.
authors.affiliation: Wohl Virion Centre, Department of Immunology and Molecular Pathology, University College London, London W1T 4JF, United Kingdom.
authors.forename: Caroline
authors.initials: C
authors.lastname: Besnier
authors.forename: Laura
authors.initials: L
authors.lastname: Ylinen
authors.forename: Benjamin
authors.initials: B
authors.lastname: Strange
authors.forename: Adrian
authors.initials: A
authors.lastname: Lister
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Goff
authors.forename: Greg J
authors.initials: GJ
authors.lastname: Towers
mesh_terms: D000818:Animals; D002417:Cattle; D002460:Cell Line; D006224:Cricetinae; D006801:Humans; D009052:Leukemia Virus, Murine / Q000472:pathogenicity* / Q000502:physiology*; D008322:Mammals / Q000821:virology*; D051379:Mice; D041681:NIH 3T3 Cells; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: C103189:Fv1 protein, mouse; D011506:Proteins