Modelling the controls of the eukaryotic cell cycle.
The eukaryotic cell-division cycle is regulated by three modules that control G(1)/S, G(2)/M and meta/anaphase transitions. By using mathematical modelling, we show the dynamic characteristics of these individual modules and we also assemble them together into a comprehensive model of the eukaryotic cell-division cycle. With this comprehensive model, we also discuss the mechanisms by which different checkpoint pathways stabilize different cell-cycle states and inhibit the transitions that drive cell-cycle progression.
Novák
B
B
Molecular Network Dynamics Research Group of Hungarian Academy of Sciences and Budapest University of Technology and Economics, 1521 Budapest, Gellért tér 4, Hungary. bnovak@mail.bme.hu
Tyson
J J
JJ
D002453:Cell Cycle; D005057:Eukaryotic Cells; D008954:Models, Biological