title: Flavonoids from Dalbergia louvelii and their antiplasmodial activity.
abstract: Four new flavonoids (1-4), along with 13 known compounds, were isolated from the heartwood of Dalbergia louvelii by following their potential to inhibit in vitro the growth of Plasmodium falciparum. Of the isolated compounds, four known compounds showed antiplasmodial activity with IC(50) values ranging from 5.8 to 8.7 microM, namely, (R)-4' '-methoxydalbergione (5), obtusafuran (6), 7,4'-dihydroxy-3'-methoxyisoflavone (7), and isoliquiritigenin (8). The structures of the new compounds were determined using spectroscopic techniques as 1-(3-hydroxyphenyl)-3-(4-hydroxy-2,5-dimethoxyphenyl)propane (1), spirolouveline (2), (3R)-7,2'-dihydroxy-4',5'-dimethoxyisoflavanone (3), and 3-(2,4-dihydroxy-5-methoxy)phenyl-7-hydroxycoumarin (4), respectively.
authors.affiliation: USM 0502-UMR 8041CNRS Chimie et Biochimie des Substances Naturelles, Muséum National d'Histoire Naturelle, 63 Rue Buffon, 75231 Paris Cedex 05, France.
authors.forename: Naïma
authors.initials: N
authors.lastname: Beldjoudi
authors.forename: Lengo
authors.initials: L
authors.lastname: Mambu
authors.forename: Mehdi
authors.initials: M
authors.lastname: Labaïed
authors.forename: Philippe
authors.initials: P
authors.lastname: Grellier
authors.forename: David
authors.initials: D
authors.lastname: Ramanitrahasimbola
authors.forename: Philippe
authors.initials: P
authors.lastname: Rasoanaivo
authors.forename: Marie Thérèse
authors.initials: MT
authors.lastname: Martin
authors.forename: François
authors.initials: F
authors.lastname: Frappier
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D035782:Dalbergia / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008270:Madagascar; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D013237:Stereoisomerism
chemical_list: D000962:Antimalarials; D005419:Flavonoids