title: Somatotropic-axis deficiency affects brain substrates of selective attention in childhood-onset growth hormone deficient patients.
abstract: Reduced levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) are associated with deteriorated cognitive performance in senescence. Little work has been done on the effect of GH and IGF-1 on a crucial aspect of cognition, selective attention. This study investigated the effect of GH/IGF-1 on performance and brain potentials (EEG) during a selective-attention task in patients with low levels of GH and IGF-1 (childhood-onset growth hormone deficiency) compared to healthy controls. Detection of occasional visual target patterns was impaired in patients. This was paralleled by a reduction in an attention-related brain potential, which has been associated previously with anterior cingulate cortex functioning.
authors.affiliation: Department of Psychopharmacology, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands. m.lijffijt@pharm.uu.nl
authors.forename: M
authors.initials: M
authors.lastname: Lijffijt
authors.forename: P S
authors.initials: PS
authors.lastname: Van Dam
authors.forename: J L
authors.initials: JL
authors.lastname: Kenemans
authors.forename: H P F
authors.initials: HP
authors.lastname: Koppeschaar
authors.forename: W R
authors.initials: WR
authors.lastname: de Vries
authors.forename: M L
authors.initials: ML
authors.lastname: Drent
authors.forename: A
authors.initials: A
authors.lastname: Wittenberg
authors.forename: C
authors.initials: C
authors.lastname: Kemner
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D005071:Evoked Potentials; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000172:deficiency*; D008297:Male; D010364:Pattern Recognition, Visual / Q000502:physiology; D010775:Photic Stimulation
chemical_list: D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I