title: Possible contribution of circulating interleukin-10 (IL-10) to anti-tumor immunity and prognosis in patients with unresectable hepatocellular carcinoma.
abstract: OBJECTIVES: Interleukin-10 (IL-10) has been implicated in immune deficiency in patients with cancer. The relationship of this cytokine as measured in serum to anti-tumor immunity and prognosis was investigated in unresectable hepatocellular carcinoma. METHODS: This study consisted of 74 consecutive patients with unresectable hepatocellular carcinoma (median age, 65 years). Forty-four healthy age-matched subjects and 32 patients with cirrhosis but no carcinoma served as controls. Patients with hepatocellular carcinoma were divided into those with serum IL-10 concentrations above (high group, n=39) or below (low group, n=35) 10pg/ml. RESULTS: Age, gender, Child-Pugh grade, and tumor stage distributions were similar in high and low groups. The patients of high group showed lower in lymphokine-activated killer (LAK) and natural killer (NK) activities than those of low group (P<0.01 and 0.01, respectively). Serum IL-10 concentration was a significant factor contributing to low activities of LAK and NK by logistic regression analysis (P<0.05 and 0.05, respectively). The high group had a significantly shorter survival (median, 3 months) than low group (median, 12 months; P<0.02, generalized Wilcoxon test). CONCLUSIONS: These data suggest that serum IL-10 concentration is a possible factor contributing to poor prognosis and low anti-tumor immunity in patients with unresectable hepatocellular carcinoma.
authors.affiliation: Second Department of Internal Medicine, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, 990-9585, Yamagata, Japan
authors.forename: Etsuko
authors.initials: E
authors.lastname: Hattori
authors.forename: Kazuo
authors.initials: K
authors.lastname: Okumoto
authors.forename: Tohru
authors.initials: T
authors.lastname: Adachi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Takeda
authors.forename: Jun itsu
authors.initials: J
authors.lastname: Ito
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sugahara
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Koji
authors.initials: K
authors.lastname: Saito
authors.forename: Takafumi
authors.initials: T
authors.lastname: Saito
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Togashi
authors.forename: Sumio
authors.initials: S
authors.lastname: Kawata