Effect of micronized fenofibrate on vascular endothelial function in patients with hypertriglyceridemia.
OBJECTIVE
To investigate the effect of micronized fenofibrate on vascular endothelial function in patients with hypertriglyceridemia.


METHODS
Using high-resolution ultrasound, we measured flow- and nitroglycerin-induced dilatation of the brachial artery in 30 patients with hypertriglyceridemia before and after treatment with micronized fenofibrate at a dose of 200 mg once daily for 4 weeks. Simultaneously, both serum lipid and plasma endothelin (ET) levels were determined.


RESULTS
After micronized fenofibrate therapy, serum triglyceride (TG) levels decreased significantly (P < 0.05). Plasma ET levels also decreased markedly [(82.66 +/- 15.46) microg/L vs. (106.22 +/- 19.16) microg/L, P < 0.001]. Flow-induced vasodilatation was much improved (11.0% +/- 9.0% vs 2.7% +/- 2.0%, P < 0.01). However, no significant changes in vasodilatation occurred in response to nitroglycerin (16.2% +/- 6.0% vs 15.0% +/- 5.0%, P > 0.05) in patients with hypertriglyceridemia.


CONCLUSIONS
Micronized fenofibrate can improve impaired endothelium-dependent vasodilatation in patients with hypertriglyceridemia. Improving endothelial function may also be the mechanism responsible for the beneficial effects of micronized fenofibrate.
Huang
Yun
Y
Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. huangyun1207@163.com
Dai
Guizhu
G
Feng
Zongchen
Z
Lu
Chengfa
C
Cheng
Bei
B
Wang
Qiufen
Q
Nie
Fuding
F
Li
Jingdong
J
D000328:Adult; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D005260:Female; D011345:Fenofibrate / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D014664:Vasodilation / Q000187:drug effects
D011345:Fenofibrate