Occupational exposure and urological cancer.
Occupational exposure is definitely a major cause of cancer. In the field of urology, the urinary bladder is the most important target. A classical cause of bladder cancer is exposure to carcinogenic aromatic amines, especially benzidine and beta-naphthylamine. Such exposures were related to work places in the chemical industry, implying production and processing of classical aromatic amines, and in the rubber industry. Occupational bladder cancer has also been observed in dyers, painters and hairdressers. Even some occupations with much lower exposures to carcinogenic aromatic amines, like coke oven workers or workers in the rubber industry after the ban on beta-naphthylamine, are at risk. In these occupations, exposure to complex mixtures of substances containing combustion products (e.g. polycyclic aromatic hydrocarbons) or nitrosamines is common. Renal cell cancer has been observed as an occupational disease in cases of very high exposure to trichloroethylene having led to narcotic or prenarcotic symptoms. Occupationally related cancers of the prostate or the testes appear currently not relevant.
Golka
Klaus
K
Institute for Occupational Physiology at the University of Dortmund (IfADo), Ardeystr. 67, 44139 Dortmund, Germany. golka@ifado.de
Wiese
Andreas
A
Assennato
Giorgio
G
Bolt
Hermann M
HM
D000588:Amines / Q000009:adverse effects; D002292:Carcinoma, Renal Cell / Q000139:chemically induced*; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000139:chemically induced*; D008297:Male; D009602:Nitrosamines / Q000009:adverse effects; D016273:Occupational Exposure / Q000009:adverse effects*; D011084:Polycyclic Aromatic Hydrocarbons / Q000009:adverse effects; D014241:Trichloroethylene / Q000009:adverse effects; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D000588:Amines; D009602:Nitrosamines; D011084:Polycyclic Aromatic Hydrocarbons; D014241:Trichloroethylene