title: Silica-based monoliths for capillary electrochromatography: methods of fabrication and their applications in analytical separations.
abstract: This review article is intended to provide the reader with the recent advances made in the fabrication of silica-based monolithic capillary columns for use in capillary electrochromatography (CEC). The silica-based monoliths can be produced by three different approaches, namely (i) fusion of silica particles by thermal sintering, (ii) cross-linking/entrapping silica particles in a packed bed using the sol-gel process, and (iii) polymerization of silicon alkoxide precursors using the sol-gel process. Thus far, approach (iii) is the most widely used for fabricating silica monoliths. After providing a thorough description of each of the three approaches used for the production of silica-based monolithic capillary columns, the analytical separations performed by CEC on each kind of monolith are discussed.
authors.affiliation: Department of Chemistry, Oklahoma State University, Stillwater, OK 74078-3071, USA.
authors.forename: Darin
authors.initials: D
authors.lastname: Allen
authors.forename: Ziad
authors.initials: Z
authors.lastname: El Rassi
mesh_terms: D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D011108:Polymers; D012821:Silanes; D012822:Silicon Dioxide; D012825:Silicon