title: The activity in the CNS catecholaminergic systems covaries with thyroid hormone metabolism in humans.
abstract: Do the CNS monoaminergic (MA) systems regulate thyroid hormone metabolism in humans? In 23 unmedicated, male, violent offenders without signs of thyroid disease, we found positive correlations between the catecholaminergic CSF metabolites HVA and MHPG and the peripheral T3/T4 ratio (rho=0.55, p=0.010 and 0.51, p=0.018), indicating that increased activity in the brain MA systems, especially the dopaminergic, is associated with increased peripheral thyroid hormone activity.
authors.affiliation: Institute of Surgical Sciences, Göteborg University, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Yhede
authors.forename: K
authors.initials: K
authors.lastname: Blennow
authors.forename: A
authors.initials: A
authors.lastname: Forsman
authors.forename: H
authors.initials: H
authors.lastname: Soderstrom
mesh_terms: D000328:Adult; D015306:Biogenic Monoamines / Q000134:cerebrospinal fluid* / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D013963:Thyroid Hormones / Q000097:blood*; D014754:Violence
chemical_list: D015306:Biogenic Monoamines; D013963:Thyroid Hormones