The source of cells for allografting.
Peripheral blood is used almost exclusively as the source of hematopoietic cells for autografting, but the best source of cells for allografting is the subject of considerable discussion and debate. Randomized studies comparing unstimulated bone marrow with G-CSF-mobilized peripheral blood in the sibling allogeneic setting have indicated a trend to more chronic graft-versus-host disease in peripheral blood recipients. However, whether the use of G-CSF-mobilized peripheral blood cells leads to more acute graft-versus-host disease is uncertain. Adults undergoing sibling allografting appear to benefit in terms of improved disease-free survival or improved overall survival with the use of G-CSF-mobilized peripheral blood. It is not clear, however, whether these benefits also extend to children or those undergoing matched unrelated transplantation.
Couban
Stephen
S
Department of Medicine, Queen Elizaberth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada. stephen.couban@cdha.nshealth.ca
Barnett
Michael
M
D016026:Bone Marrow Transplantation / Q000379:methods; D002648:Child; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods; D006412:Hematopoietic Stem Cells; D006801:Humans; D011994:Recombinant Proteins; D014184:Transplantation, Homologous / Q000706:statistics & numerical data*
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor