Kinetics of amide and peptide cleavage by alkaline hydrogen peroxide.
The hydroperoxide anion cleaves unactivated amides and peptides although it is completely unreactive toward ethyl esters. The cleavage by HO2(-) proceeds faster than by OH(-) and involves additional routes with general acid assistance by H2O2 and general base assistance by OH(-) and HO2(-). Cleavage of polypeptides occurs at the N-terminal peptide bond. [reaction: see text]
Gómez-Reyes
Baldomero
B
Facultad de Química, Universidad Nacional Autónoma de México, 04510 D.F., Mexico.
Yatsimirsky
Anatoly K
AK
D000468:Alkalies / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry*; D007700:Kinetics; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*
D000468:Alkalies; D000577:Amides; D010455:Peptides; D006861:Hydrogen Peroxide