Triterpenoids from Schisandra henryi with cytotoxic effect on leukemia and Hela cells in vitro.
Four known lanostane triterpenoids, schiprolactone A (1), schisanlactone B (2), nigranoic acid (3) and schisandronic acid (4) were isolated from the stems of Schisandra henryi for the first time. Their structures were characterized by IR, MS and NMR techniques. Compounds 1, 2 and 4 showed moderate cytotoxic activity against Leukemia cells in vitro. Cytotoxic activity of compounds 1-4 showed IC50 of 0.0097, 0.01, 0.097 and 0.0099 micromol/mL respectively toward Leukemia cells and IC50 of 0.097, 0.1, 0.097 and 0.099 micromol/mL toward Hela cells respectively. It is the first report that these compounds possess cytotoxic activity on Leukemia and Hela cells.
Chen
Ye-Gao
YG
Department of Chemistry, Yunnan Normal University, Kunming 650092, China. ygchen48@hotmail.com
Wu
Zheng-Cai
ZC
Lv
Yu-Ping
YP
Gui
Shi-Hong
SH
Wen
Jin
J
Liao
Xin-Rong
XR
Yuan
Li-Ming
LM
Halaweish
Fathi
F
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006367:HeLa Cells; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000473:pathology*; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D018547:Plant Stems; D032141:Schisandra; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D010936:Plant Extracts; D014315:Triterpenes