Vaginal colonization by orally administered Lactobacillus rhamnosus GG.
BACKGROUND
The lack of lactobacilli in the vagina of postmenopausal women due to estrogen deficiency plays an important role in the development of bacteriuria. In the last few years the use of lactobacilli for the prevention of genitourinary infections has been explored using different probiotic strains.


OBJECTIVE
To evaluate the vaginal colonization by Lactobacillus rhamnosus GG in postmenopausal healthy women following oral administration of the bacteria in a yogurt base for 1 month, as a first step in evaluating the potential probiotic role of LGG in the prevention of recurrent urinary tract infections.


METHODS
One or two doses per day of yogurt containing 10(9) colony-forming units of LGG were administered orally to 42 postmenopausal healthy women for 1 month. Vaginal and rectal swabs were cultured at the beginning and end of the study.


RESULTS
At the end of the study the vaginas of only four women (9.5%) were colonized with LGG, at a very low number of bacteria, despite the fact that the gastrointestinal tracts of 33 women (78.6%) were colonized. There were no significant differences between one or two doses daily.


CONCLUSIONS
LGG should not be considered as a probiotic agent in urinary infections since it does not attach well to the vaginal epithelium.
Colodner
Raul
R
Clinical Microbiology Laboratory, HaEmek Medical Center, Afula, Israel. colodner_ra@clalit.org.il
Edelstein
Hana
H
Chazan
Bibiana
B
Raz
Raul
R
D000284:Administration, Oral; D000368:Aged; D018407:Bacterial Physiological Phenomena; D015169:Colony Count, Microbial; D005260:Female; D006801:Humans; D007778:Lactobacillus / Q000254:growth & development* / Q000302:isolation & purification; D008875:Middle Aged; D010865:Pilot Projects; D017698:Postmenopause; D019936:Probiotics / Q000008:administration & dosage*; D012007:Rectum / Q000382:microbiology; D055502:Secondary Prevention; D014552:Urinary Tract Infections / Q000178:diet therapy / Q000517:prevention & control; D014621:Vagina / Q000382:microbiology*; D015014:Yogurt / Q000382:microbiology