Placental metastasis of maternal melanoma.
Metastasis of maternal malignant tumor to the products of conception is a rare event. Melanoma is the most common maternal malignant tumor to metastasize to the placenta and the fetus. We report the case of a 28-year-old woman with melanoma during pregnancy. At parturition, histologic evaluation of the placenta revealed metastatic melanoma, and multiple organ metastasis developed. The infant was free of disease. Metastasis to products of conception portends a poor prognosis for the mother. To our knowledge, this report is the first of a patient with melanoma metastasis to the placenta to survive more than 7 months after parturition. As caretakers of patients with melanoma, dermatologists are in a position to coordinate and direct the care and follow-up treatment of affected patients.
Altman
Jamie F
JF
Department of Dermatology, University of Michigan, 1910 Taubman Center, Ann Arbor, MI 48109-0314, USA.
Lowe
Lori
L
Redman
Bruce
B
Esper
Peg
P
Schwartz
Jennifer L
JL
Johnson
Timothy M
TM
Haefner
Hope K
HK
D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008545:Melanoma / Q000473:pathology*; D009362:Neoplasm Metastasis; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*