Initial predictors of development of pure red cell aplasia in myasthenia gravis after thymectomy.
Pure red cell aplasia (PRCA) is well known to be concomitant with myasthenia gravis (MG), but it is difficult to predict the development of PRCA in patients with MG. Of 135 patients with MG, four (2.9%) had PRCA. All patients developed PRCA after thymectomy during a period when MG was in remission. The frequencies of thymoma, bulbar involvement and high anti-acetylcholine receptor (AChR) antibody levels were significantly higher in four patients with PRCA. Japanese MG patients with these characteristics at presentation were at significant risk for the development of PRCA after thymectomy.
Suzuki
Shigeaki
S
Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
Nogawa
Shigeru
S
Tanaka
Kortaro
K
Koto
Atsuo
A
Fukuuchi
Yasuo
Y
Kuwana
Masataka
M
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000276:immunology / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology* / Q000276:immunology; D011950:Receptors, Cholinergic / Q000276:immunology; D012010:Red-Cell Aplasia, Pure / Q000209:etiology* / Q000276:immunology; D012307:Risk Factors; D013934:Thymectomy; D013945:Thymoma / Q000276:immunology / Q000601:surgery; D013953:Thymus Neoplasms / Q000276:immunology / Q000601:surgery
D001323:Autoantibodies; D011950:Receptors, Cholinergic