title: Lost in space: misregulated positional cues create tripotent neural progenitors in cell culture.
abstract: In a widely held view of vertebrate CNS development, neurons, astrocytes, and oligodendrocytes arise from a common tripotent progenitor cell. However, tripotent progenitors have never been detected in developing embryos. In this issue of Neuron, Gabay et al. show that tripotent progenitors can be created in vitro by deregulation of normal dorsoventral positional cues.
authors.affiliation: Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Charles D
authors.initials: CD
authors.lastname: Stiles
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D019521:Body Patterning / Q000502:physiology; D002449:Cell Aggregation; D018929:Cell Culture Techniques; D002454:Cell Differentiation / Q000502:physiology*; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D053823:Hedgehog Proteins; D051379:Mice; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D009836:Oligodendroglia / Q000378:metabolism; D051381:Rats; D013234:Stem Cells / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism
chemical_list: D053823:Hedgehog Proteins; D015534:Trans-Activators