Flavonoids from Dalbergia louvelii and their antiplasmodial activity.
Four new flavonoids (1-4), along with 13 known compounds, were isolated from the heartwood of Dalbergia louvelii by following their potential to inhibit in vitro the growth of Plasmodium falciparum. Of the isolated compounds, four known compounds showed antiplasmodial activity with IC(50) values ranging from 5.8 to 8.7 microM, namely, (R)-4' '-methoxydalbergione (5), obtusafuran (6), 7,4'-dihydroxy-3'-methoxyisoflavone (7), and isoliquiritigenin (8). The structures of the new compounds were determined using spectroscopic techniques as 1-(3-hydroxyphenyl)-3-(4-hydroxy-2,5-dimethoxyphenyl)propane (1), spirolouveline (2), (3R)-7,2'-dihydroxy-4',5'-dimethoxyisoflavanone (3), and 3-(2,4-dihydroxy-5-methoxy)phenyl-7-hydroxycoumarin (4), respectively.
Beldjoudi
Naïma
N
USM 0502-UMR 8041CNRS Chimie et Biochimie des Substances Naturelles, Muséum National d'Histoire Naturelle, 63 Rue Buffon, 75231 Paris Cedex 05, France.
Mambu
Lengo
L
Labaïed
Mehdi
M
Grellier
Philippe
P
Ramanitrahasimbola
David
D
Rasoanaivo
Philippe
P
Martin
Marie Thérèse
MT
Frappier
François
F
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D035782:Dalbergia / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008270:Madagascar; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D013237:Stereoisomerism
D000962:Antimalarials; D005419:Flavonoids