title: Lack of association between TrkA single nucleotide polymorphisms and sporadic Alzheimer's disease in a Japanese population.
abstract: Nerve growth factor and its receptor with tyrosine kinase activity (TrkA) have been implicated in the development of Alzheimer's disease (AD). Entire coding regions of TrkA gene harboring exons 1 through 17 were sequenced in 114 patients with sporadic AD and 112 control subjects in a Japanese population, and six known and two novel single nucleotide polymorphisms were identified, but no mutation associated with sporadic AD was identified. Concurrently, case-control analysis of TrkA gene A1674G polymorphism in 534 patients with sporadic AD and 454 control subjects has revealed no significant differences in TrkA genotype or allele frequencies even after stratification for Apolipoprotein E epsilon4 carrier statuses. Thus, the TrkA genotype does not appear to influence the risk of developing sporadic AD in a Japanese population.
authors.affiliation: Department of Cortical Function Disorders, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187-8502, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sakasegawa
authors.forename: Hitaru
authors.initials: H
authors.lastname: Kishida
authors.forename: Michiko
authors.initials: M
authors.lastname: Sakurai
authors.forename: Takashi
authors.initials: T
authors.lastname: Asada
authors.forename: Toru
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Goto
authors.forename: Hideo
authors.initials: H
authors.lastname: Kimura
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kuroiwa
authors.forename: Naomi S
authors.initials: NS
authors.lastname: Hachiya
authors.forename: Kiyotoshi
authors.initials: K
authors.lastname: Kaneko
mesh_terms: D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005091:Exons; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D020917:Receptor, trkA; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods
chemical_list: D002352:Carrier Proteins; D008565:Membrane Proteins; D020917:Receptor, trkA