title: [Expression of vascular endothelial growth factor in the peritoneal fluid and eutopic endometrium of patients with endometriosis].
abstract: OBJECTIVE
  To investigate the significance of vascular endothelial growth factor (VEGF) on the etiology of endometriosis.
  
  
  METHODS
  The level of VEGF in the peritoneal fluid from women with endometriosis (n = 19) and non-endometriosis (n = 21) was studied by ELISA. The expression of VEGF of eutopic endometrium collected from women with endometriosis (n = 15) and non-endometriosis (n = 12) was determined by relative quantity RT-PCR.
  
  
  RESULTS
  The level of VEGF in the peritoneal fluid in the endometriosis was higher than that of the controls (P < 0.05). Cyclic variation in VEGF concentration was seen in the peritoneal fluid from patients with endometriosis, and the VEGF concentration in the proliferative phase was significantly higher than that in the secretory phase (P < 0.05). No cyclic variation in VEGF was seen in the control group (P > 0.05). The expression of VEGF in the eutopic endometrium with endometriosis was significantly higher than that of the controls (P < 0.001). There was no significant difference between the proliferative and secretory phase in endometriosis (P > 0.05).
  
  
  CONCLUSIONS
  The increase of VEGF in the peritoneal fluid and eutopic endometrium with endometriosis may be important to the occurrence and development of endometriosis.
authors.affiliation: Department of Gynecology and Obstetrics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Xiao-ling
authors.initials: XL
authors.lastname: Fang
authors.forename: Xiao-meng
authors.initials: XM
authors.lastname: Xia
authors.forename: Qiu-hua
authors.initials: QH
authors.lastname: Lin
mesh_terms: D000328:Adult; D001202:Ascitic Fluid / Q000378:metabolism*; D004715:Endometriosis / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D010388:Pelvis; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D042461:Vascular Endothelial Growth Factor A