Disseminated trichosporonosis in China.
A 20-year-old female patient presented with erythematous plaques on the nose which were progressively spreading to the trunk and the extremities, sometimes with erosions and scars. The patient was misdiagnosed as having seborrhoeic dermatitis and subacute cutaneous lupus erythematosus. The histopathological biopsy revealed mycotic infectious granuloma. Samples taken from skin lesions and other locations grew Trichosporon asahii in cultures. The identification was confirmed by molecular biological methods. The patient was treated successfully with liposomal amphotericin B in combination with fluconazole orally.
Yang
R
R
Department of Dermatology, General Hospital of Beijing Military Command of PLA, Beijing, China.
Ao
J
J
Wang
W
W
Song
K
K
Li
R
R
Wang
D
D
D000328:Adult; D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use; D002681:China; D004275:DNA, Ribosomal / Q000737:chemistry / Q000302:isolation & purification; D003881:Dermatomycoses / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology* / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D015725:Fluconazole / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D016533:Mycological Typing Techniques; D009181:Mycoses / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D012335:RNA, Ribosomal / Q000235:genetics; D017422:Sequence Analysis, DNA; D014250:Trichosporon / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification*
D000935:Antifungal Agents; D004275:DNA, Ribosomal; D012335:RNA, Ribosomal; C065096:RNA, ribosomal, 26S; D000666:Amphotericin B; D015725:Fluconazole