[Effects of ursolic acid on liver-protection and bile secretion].
OBJECTIVE
To study the liver-protection and promoting bile secretion of ursolic acid.


METHODS
Ursolic acid was administrated to the mice with liver injury induced by CCl4 or APIT. ALT, AST levels in serum were examined. The bile flow rate and the concentration of the main components in the bile of rats administrated with ursolic acid were estimated.


RESULTS
Ursolic acid could decrease the serum ALT, AST, SB levels in the mice treated with CCl4 or APIT, promote the secretion of bile and increase the concentration of bilirubin in the bile.


CONCLUSIONS
Ursolic acid exhibited significant liver protection and promoting blie secretion.
Xiong
Xiaojuan
X
Yichun College, Yichun, Jiangxi 336000.
Chen
Weiyun
W
Cui
Jianglong
J
Yi
Shaobo
S
Zhang
Ziwen
Z
Li
Kaiquan
K
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001646:Bile / Q000378:metabolism*; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D017879:Isothiocyanates; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D020011:Protective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D027923:Sambucus / Q000737:chemistry; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D000097245:Ursolic Acid
D000410:Alanine Transaminase; D001219:Aspartate Aminotransferases; D004365:Drugs, Chinese Herbal; D017879:Isothiocyanates; D020011:Protective Agents; D014315:Triterpenes; D000097245:Ursolic Acid; C058305:phenethyl isothiocyanate