title: [Gene expression of MMP1 and TIMP1 in lung cancer detected with a cDNA microarray technique].
abstract: OBJECTIVE
  To investigate the gene expression of matrix metalloproteinases 1 (MMP1) and tissue inhibitors of matrix metalloprotainases 1(TIMP1) in squmas cell lung cancer and adenocarcinoma.
  
  
  METHODS
  Gene expression profile cDNA microarray egntaining 4,096 genes was used to identify differentially expressed genes in squmas cell lung cancer and adenocarcinoma, and to analyze the gene expression of MMP1 and TIMP1.
  
  
  RESULTS
  Gene MMP1 and TIMP1 were differentially expressed in both squmas cell lung cancer and adenocarcinoma, and both of them were up-regulated.
  
  
  CONCLUSIONS
  MMP1 and TIMP1 may be important molecular markers of squmas cell lung cancer and adenocarcinoma.
authors.affiliation: Department of Respiration, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Qu-chang
authors.initials: QC
authors.lastname: Ouyang
authors.forename: Cheng-ping
authors.initials: CP
authors.lastname: Hu
authors.forename: Qing-hua
authors.initials: QH
authors.lastname: Liang
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000235:genetics; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000235:genetics*; D020781:Matrix Metalloproteinase 1 / Q000235:genetics* / Q000378:metabolism; D020411:Oligonucleotide Array Sequence Analysis; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000235:genetics* / Q000378:metabolism
chemical_list: D019715:Tissue Inhibitor of Metalloproteinase-1; D020781:Matrix Metalloproteinase 1