[Relationship between ALDH gene polymorphism and alcoholic liver diseases].
OBJECTIVE
To study the relationship between aldehyde dehydrogenase (ALDH) gene polymorphism and alcoholic liver disease, and investigate the genetic pathogenesis of alcoholic liver disease (ALD).


METHODS
PCR, restriction endonuclease and electrophoresis were used, to detect the genotypes and alleles frequencies of ALDH gene in patients in the control group, alcohol dependent group and ALD group, and each group contained 20 patients.


RESULTS
The frequencies of ALDH2*1 and ALDH2*2 allele had statistic significance between control group and ALD group (x2=4.80, P<0.05), and no statistic significance between control group and alcohol dependent group. ALDH2*1/*1 was predominant in alcohol dependent group and ALD group, while ALDH2*2/*2 was not detected.


CONCLUSIONS
The gene polymorphism of ALDH is close to ALD. The allele of ALDH2*2 may be a negative risk factor for the developing of ALD
Yan
Ming
M
Department of Gastroenterology, Qilu Hospital, Shandong University, Ji'nan 250012, China.
Zhu
Kong-xi
KX
Meng
Fan-li
FL
Wang
Hong-juan
HJ
Wu
Mei-ling
ML
D000328:Adult; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000483:Alleles; D005787:Gene Frequency; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D012307:Risk Factors
D000444:Aldehyde Dehydrogenase