title: Constituents of Hypericum laricifolium and their cyclooxygenase (COX) enzyme activities.
abstract: Investigation of the aerial parts of the medicinal plant Hypericum laricifolium led to the isolation of two new natural products, hentriacontanyl caffeate (1a), nonacosanyl caffeate (1b). In addition, stigmasterol, beta-sitosterol, 3-epi-betulinic acid (2), caffeic acid (3), ferulic acid, docosanol, p-hydroxybenzoic acid, 3,4-dimethoxy benzoic acid, quercetin (4), quercetin-3-O-galactoside (5), quercetin-3-O-rutinoside (6), quercetin-3-O-rhamnoside (7), quercetin-3-O-glucuronide (8) and shikimic acid were also isolated. The structures were determined by 1D- and 2D-NMR, mass spectrometry, and chemical transformations. The anti-inflammatory effects of the isolated compounds were discussed briefly.
authors.affiliation: Division of Pharmacognosy, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, Sweden. Hesham.El-Seedi@fkog.uu.se
authors.forename: Hesham Rushdey
authors.initials: HR
authors.lastname: El-Seedi
authors.forename: Therese
authors.initials: T
authors.lastname: Ringbom
authors.forename: Kurt
authors.initials: K
authors.lastname: Torssell
authors.forename: Lars
authors.initials: L
authors.lastname: Bohlin
mesh_terms: D000818:Animals; D002417:Cattle; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D020902:Hypericum / Q000737:chemistry*; D007527:Isoenzymes / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018514:Plant Structures; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D012756:Sheep
chemical_list: D004791:Enzyme Inhibitors; D007527:Isoenzymes; D010936:Plant Extracts; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases