title: [A case of pseudoscleroderma as paraneoplastic syndrome due to carcinoma of cervical uteri].
abstract: A 65-year-old female began experiencing arthralgia, morning stiffness and psychroesthesia in April 2000. She visited a rheumatologist and was suspected of having early-stage rheumatoid arthritis. She was referred to our hospital, and was admitted in December 2000. At that time, sclerosis of the skin was advanced, and Raynaud's phenomenon was confirmed. The patient also exhibited nailfold bleeding, and was diagnosed as having systemic scleroderma. She visited a gynecologist for screening and cervical uteri carcinoma was confirmed. She underwent surgery in March 2001, and subsequently, sclerosis in her skin was almost stopped. We believe that these clinical symptoms were related to paraneoplastic syndrome. We therefore immunochemically investigated the pathogenesis of paraneoplastic syndrome and found that connective tissue growth factor (CTGF) might be involved and transforming growth factor-beta (TGF-beta) might not be involved in this case.
authors.affiliation: First Department of Internal Medicine, Sapporo Medical University, School of Medicine.
authors.forename: Motohisa
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Chisako
authors.initials: C
authors.lastname: Suzuki
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Naishiro
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsukuda
authors.forename: Rieko
authors.initials: R
authors.lastname: Murakami
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Kohzoh
authors.initials: K
authors.lastname: Imai
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D005260:Female; D006801:Humans; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D012595:Scleroderma, Systemic / Q000209:etiology*; D002583:Uterine Cervical Neoplasms / Q000150:complications*