The effect of ruthenium(III) chloride on the formation of protonated parent ions in electrospray mass spectrometry.
We report the use of RuCl3 as an "alkali metal sponge". This is a general and highly efficient method for generating protonated parent ions for a variety of compounds that usually do not show this ion in electrospray mass spectrometry. This technique is demonstrated to be highly useful in "cleaning up" spectra from multiply metallated ions, thereby substantially improving the signal-to-noise ratio.
Stark
Christian B W
CB
University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge, UK CB2 1EW.
Lopes
Norberto P
NP
Fonseca
Tatiana
T
Gates
Paul J
PJ
D003505:Cyclodextrins / Q000737:chemistry; D005663:Furans / Q000737:chemistry; D007477:Ions / Q000737:chemistry; D008985:Monensin / Q000737:chemistry; D011522:Protons; D017975:Ruthenium Compounds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D014634:Valinomycin / Q000737:chemistry; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D005663:Furans; D007477:Ions; D011522:Protons; D017975:Ruthenium Compounds; D047392:beta-Cyclodextrins; D014634:Valinomycin; C038119:heptakis(2,6-O-dimethyl)beta-cyclodextrin; D008985:Monensin; C055416:tetronasin; C038365:ruthenium chloride