[A comparative study of the treatment of high grade gliomas].
BACKGROUND
The influence of surgery, radiotherapy and/or chemotherapy on the outcome on the results in patients with malignant gliomas is controversial.


METHODS
We studied 44 patients (26, women; 18 men; age 38 72 years) diagnosed with grades III and IV astrocytoma who had been operated and then received adjuvant radiotherapy and either BCNU or temozolamyde chemotherapy. Survival time and adverse effects of the chemotherapy were analysed.


CONCLUSIONS
Aggressive surgery associated with radiotherapy and temozolamyde chemotherapy prolonged survival in our patients with malignant astrocytomas.
Budke
M
M
Servicio de Neurocirugía, Hospital Universitario La Paz, Madrid, España. neurobudke@yahoo.es
Isla-Guerrero
A
A
Pérez-López
C
C
Pérez-Alvarez
M
M
García-Grande
A
A
Bello
M J
MJ
Rey
J
J
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D001254:Astrocytoma / Q000401:mortality / Q000628:therapy*; D001932:Brain Neoplasms / Q000401:mortality / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015996:Survival Rate
D000970:Antineoplastic Agents