Resiniferatoxin reversibly blocks adjuvant-induced thermal hyperalgesia in the rat.
The role of capsaicin-sensitive sensory afferents and mast cells in complete Freund's adjuvant (CFA)-induced thermal hyperalgesia and edema was investigated in rats. A single systemic injection of resiniferatoxin produced a reversible prevention of adjuvant-induced thermal hyperalgesia which lasted several days. In addition, resiniferatoxin markedly reduced the early edema. Chronic degranulation of mast cells with compound 48/80 also reduced the thermal hyperalgesia and edema, especially in the early phase of inflammation. Co-pretreatment with resiniferatoxin and compound 48/80 induced effects similar to those of resiniferatoxin alone. The data support the involvement of capsaicin-sensitive fibers in the adjuvant-induced inflammation.
Zhang
Yi-Hong
YH
Institute of Neurobiology, Fudan University, 220 Handan Road, Shanghai 200433, China.
Chen
Yong
Y
Zhao
Zhi-Qi
ZQ
D000818:Animals; D004224:Diterpenes / Q000627:therapeutic use*; D005620:Freund's Adjuvant / Q000633:toxicity*; D006358:Hot Temperature / Q000009:adverse effects; D006930:Hyperalgesia / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000473:pathology; D051381:Rats
D004224:Diterpenes; D005620:Freund's Adjuvant; C024353:resiniferatoxin