Highly stereoselective synthesis of (-)-monatin, a high-intensity sweetener, using chelation-controlled nitrone cycloaddition.
Synthesis of (-)-monatin was achieved by chelation-controlled cycloaddition of nitrone 2 with allyl alcohol 3a in the presence of MgBr2-OEt2.
Tamura
Osamu
O
Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi, Kanazawa 920-0934, Japan. tamura@p.kanazawa-u.ac.jp
Shiro
Tomoya
T
Toyao
Atsushi
A
Ishibashi
Hiroyuki
H