Mitochondrial complex II is essential for hypoxia-induced ROS generation and vasoconstriction in the pulmonary vasculature.
Hypoxia induces an increase in the ROS generation by cells of small intrapulmonary vessels. Based on our results we suppose that this is caused by a switch in the catalytic activity of mitochondrial complex II from succinate dehydrogenase to fumarate reductase. Functional complex II is also necessary for hypoxic pulmonary vasoconstriction.
Paddenberg
Renate
R
Institute for Anatomy and Cell Biology, Justus-Liebig-University, 35385 Giessen, Germany.
Goldenberg
Anna
A
Faulhammer
Petra
P
Braun-Dullaeus
Ruediger C
RC
Kummer
Wolfgang
W
D000818:Animals; D042963:Electron Transport Complex II / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D066298:In Vitro Techniques; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D009574:Nitro Compounds; D011422:Propionates / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013804:Thenoyltrifluoroacetone / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology
D009574:Nitro Compounds; D011422:Propionates; D017382:Reactive Oxygen Species; D013804:Thenoyltrifluoroacetone; D042963:Electron Transport Complex II; D013385:Succinate Dehydrogenase; C015392:3-nitropropionic acid