Association between folic acid food fortification and congenital orofacial clefts.
By January 1998, most of Canada's cereal grain products were being fortified with folic acid. Among 336963 women who underwent antenatal maternal serum screening, the prevalence of orofacial clefts did not change from before (1.15 per 1000) to after (1.21 per 1000) food fortification (prevalence ratio, 1.06; 95% confidence interval, 0.86-1.30).
Ray
Joel G
JG
Department of Laboratory Medicine, University of Toronto, Toronto, Ontario, Canada. jray515445@aol.com
Meier
Chris
C
Vermeulen
Marian J
MJ
Wyatt
Philip R
PR
Cole
David E c
DE
D002170:Canada / Q000453:epidemiology; D002971:Cleft Lip / Q000453:epidemiology / Q000517:prevention & control*; D002972:Cleft Palate / Q000453:epidemiology / Q000517:prevention & control*; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage*; D005527:Food, Fortified; D006397:Hematinics / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D015397:Program Evaluation; D012189:Retrospective Studies
D006397:Hematinics; D005492:Folic Acid