Genotypes of Pneumocystis jiroveci isolates obtained in Harare, Zimbabwe, and London, United Kingdom.
Isolates of Pneumocystis jiroveci from sulfa-exposed and nonexposed patients from London, United Kingdom, and Harare, Zimbabwe, were genotyped. At the dihydropteroate synthase (DHPS) locus, there was evidence of selection pressure from sulfa drug exposure, and reversal of DHPS genotype ratios occurred when selection pressure was absent or was removed.
Miller
Robert F
RF
Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London, London WC1E 6AU, United Kingdom. rmiller@gum.ucl.ac.uk
Lindley
Austin R
AR
Ambrose
Helen E
HE
Malin
Adam S
AS
Wakefield
Ann E
AE
D005838:Genotype; D015658:HIV Infections / Q000150:complications; D015497:HIV-1; D006801:Humans; D008131:London; D009181:Mycoses / Q000382:microbiology*; D011010:Pneumocystis / Q000235:genetics*; D016720:Pneumocystis Infections / Q000382:microbiology*; D012335:RNA, Ribosomal / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology; D006113:United Kingdom; D015030:Zimbabwe
D012335:RNA, Ribosomal; D012367:RNA, Viral; D015662:Trimethoprim, Sulfamethoxazole Drug Combination