Conductometric and spectrofluorimetric characterization of the mixed micelles constituted by dodecyltrimethylammonium bromide and a tricyclic antidepressant drug in aqueous solution.
Conductivity and static fluorescence measurements have been carried out at 25 degrees C to study the monomeric and micellar phases of aqueous solutions of mixed micelles constituted by a conventional cationic surfactant, dodecyltrimethylammonium bromide (D(12)TAB), and a tricyclic antidepressant drug, amitriptyline hydrochloride (AMYTP), with aggregation properties. From conductivity data, the total mixed critical micelle concentration and the dissociation degree of the mixed micelle have been obtained, while fluorescence experiments allow for the determination of the total aggregation number, and the micropolarity of micellar inside. Furthermore, the partial contribution of each surfactant to the mixed micellization process, through their critical micelle concentrations and their aggregation numbers have been determined, as well. The solubilization of the drug in the mixed micelles has been also studied through the mass action model, by determining the association constant between the micelles and the drug. From these results, the use of the micelles studied in this work as potential models for vectors of antidepressant drugs of the amitriptyline family has been discussed. The theoretical aspects of the mixed micellization process have been also analyzed.
Rodríguez
Alberto
A
Departamento de Química Física I, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040, Madrid, Spain.
Junquera
Elena
E
del Burgo
Patricia
P
Aicart
Emilio
E
D000639:Amitriptyline / Q000737:chemistry*; D000929:Antidepressive Agents, Tricyclic / Q000737:chemistry*; D003217:Conductometry; D004553:Electric Conductivity; D005470:Fluorometry; D008823:Micelles; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D012996:Solutions; D014867:Water / Q000737:chemistry
D000929:Antidepressive Agents, Tricyclic; D008823:Micelles; D000644:Quaternary Ammonium Compounds; D012996:Solutions; D014867:Water; D000639:Amitriptyline; C022806:dodecyltrimethylammonium