[Age-specific reference ranges for serum prostate-specific antigen in Chinese men].
OBJECTIVE
To evaluate the age-specific reference ranges for serum prostate-specific antigen in Chinese men.


METHODS
Serum tPSA and fPSA were measured by enzyme-linked immunosorbent assay (ELISA) and fPSA/tPSA ratio was calculated in 1,096 health Chinese men of 23 - 85 years old. The relationship between age and PSA indexes was analyzed with simple linear regression.


RESULTS
The recommended age-specific reference range (95th percentile) for serum PSA for Chinese were: 1.20 microg/L for 20-29 years; 1.21microg/L for 30-39 years; 1.23 microg/L for 40-49 years; 2.35 microg/L for 50-59 years; 3.20 microg/L for 60-69 years; 3.39 microg/L for >or= 70 years. The serum PSA concentration correlated directly with age. The age-specific reference range was lower for Chinese men than not only for white and black men, but also for Japanese and Koreans men.


CONCLUSIONS
The age-specific reference ranges for serum PSA are lower significantly for Chinese men than for black, white men, even for Japanese and Koreans men. Study the normal upper limit of PSA and the age-specific reference ranges for serum prostate-specific antigen in Chinese men is very important.
Wang
Ming-zhu
MZ
Institute of Urology of Xi'an Jiaotong University, Xi'an 710061, China.
Gao
Zhong-wei
ZW
He
Da-lin
DL
Chen
Xing-fa
XF
He
Hui
H
Wang
Wu-sheng
WS
Nan
Xun-yi
XY
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D044383:Black People; D002681:China / Q000208:ethnology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D012016:Reference Values; D044465:White People
D017430:Prostate-Specific Antigen