Preparation of buccal patch composed of carbopol, poloxamer and hydroxypropyl methylcellulose.
A polymeric film composed of Carbopol, Poloxamer and hydroxypropyl methylcellulose was prepared to develop a buccal patch and the effects of composition of the film on adhesion time, swelling ratio, and dissolution of the film were studied. The effects of plasticizers or penetration enhancers on the release of triamcinolone acetonide (TAA) were also studied. The hydrogen bonding between Carbopol and Poloxamer played important role in reducing swelling ratio and dissolution rate of polymer film and increasing adhesion time. The swelling ratio of the composite film was significantly reduced and the adhesion time was increased when compared with Carbopol film. As the ratio of Poloxamer to hydroxypropyl methylcellulose increased from 0/66 to 33/33, the release rate of TAA decreased. However, no further significant decrease of release rate was observed beyond the ratio of 33/33. The release rate of TAA in the polymeric film containing polyethylene glycol 400, a plasticizer, showed the highest release rate followed by triethyl citrate, and castor oil. The release rate of TAA from the polymeric film containing permeation enhancers was slower than that from the control without enhancers. Therefore, these observations indicated that a preparation of a buccal patch is feasible with the polymeric film composed of Cabopol, Poloxamer and hydropropyl methylcellulose.
Chun
Myung-Kwan
MK
College of Pharmacy, Chosun University, Gwangju, Korea 501-759.
Kwak
Byoung-Tae
BT
Choi
Hoo-Kyun
HK
D000180:Acrylic Resins; D000269:Adhesives / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D000278:Administration, Buccal; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics*; D009061:Mouth Mucosa / Q000187:drug effects / Q000378:metabolism; D020442:Poloxamer / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D011145:Polyvinyls / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D012995:Solubility
D000180:Acrylic Resins; D000269:Adhesives; D011145:Polyvinyls; C006912:carboxypolymethylene; D020442:Poloxamer; D065347:Hypromellose Derivatives; D008747:Methylcellulose