title: [Bradykinin receptors: towards new pathophysiological roles].
abstract: In addition to being a pro-inflammatory mediator, bradykinin is now recognized as a neuromediator and regulator of several vascular and renal functions. New breakthroughs point to unusual and atypical signalling pathways for a G-protein coupled receptor that could explain the anti-proliferative and anti-fibrogenic effects of bradykinin. The availability of transgenic and knock out animal models for bradykinin receptors or bradykinin-synthesizing or -catabolic enzymes confirms these cardiac and renal protective roles for this peptide system. Bradykinin receptors are involved in the therapeutic action of angiotensin-1 converting enzyme inhibitors that are used in the treatment of arterial hypertension, heart failure and diabetes. Nevertheless, recent evidence highlights dissimilar mechanisms in the regulation and function of these receptors between the central nervous system and peripheral tissues. Therefore, the development of more specific bradykinin receptor agonists or antagonists devoid of central actions seems to evolve as a new therapeutic approach.
authors.affiliation: Inserm U.388, Institut Louis Bugnard, CHU Rangueil, avenue Jean-Poulhas, 31403 Toulouse Cedex 4, France.
authors.forename: Jean-Loup
authors.initials: JL
authors.lastname: Bascands
authors.forename: Joost P
authors.initials: JP
authors.lastname: Schanstra
authors.forename: Réjean
authors.initials: R
authors.lastname: Couture
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Girolami
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D030801:Animals, Genetically Modified; D065168:Bradykinin Receptor Antagonists; D002320:Cardiovascular Physiological Phenomena; D003920:Diabetes Mellitus / Q000188:drug therapy; D019204:GTP-Binding Proteins / Q000494:pharmacology; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007668:Kidney / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D018002:Receptors, Bradykinin / Q000819:agonists / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D065168:Bradykinin Receptor Antagonists; D018002:Receptors, Bradykinin; D019204:GTP-Binding Proteins