[Pulse-therapy with glucocorticoids and cyclophosphamide in the treatment of thromboangiitis obliterans].
Effectiveness of glucocorticoid and cyclophosphamide pulse-therapy was studied in patients with thrombangitis abliterans (TA). We examined 28 males. All of them were treated with antiplatelet agents and vasodilators in standard doses. In addition, 16 patients received a standard three-day scheme of a glucocorticoid and cyclophosphamide pulse-therapy. The examination of the patients was carried out before the treatment and in a month. Estimation of clinical activity was made according to the BVAS index, serum levels of C-reactive protein (CRP) and von Willebrand factor antigen (VWF-Ag), ESR. Before the start of the treatment there were no significant differences in the values of BVAS, ESR and CRP between the groups. In a month, BVAS index, concentrations, the rate of high serum levels of CRP and frequency of amputations were significantly reduced in patients treated with pulse-therapy. So, this pulse-therapy has a considerable anti-inflammatory effect and decreases frequency of amputations in thrombangiitis obliterans.
Gur'eva
M S
MS
Baranov
A A
AA
Bagrakova
S V
SV
Kurdiukov
A A
AA
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000008:administration & dosage*; D003907:Dexamethasone / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D020551:Pulse Therapy, Drug; D013919:Thromboangiitis Obliterans / Q000188:drug therapy*; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D005938:Glucocorticoids; D003907:Dexamethasone; D003520:Cyclophosphamide; D008775:Methylprednisolone