Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase.
Functional evidence for programmed loss of co-linearity on the borrelidin modular polyketide synthase (PKS) is presented.
Olano
Carlos
C
Departamento de Biología Funcional e Instituto Universitario de Oncologia del Principado de Asturias, Universidad de Oviedo, 33006 Oviedo, Spain.
Wilkinson
Barrie
B
Moss
Steven J
SJ
Braña
Alfredo F
AF
Méndez
Carmen
C
Leadlay
Peter F
PF
Salas
José A
JA
D000595:Amino Acid Sequence; D019677:Artificial Gene Fusion; D001483:Base Sequence; D005233:Fatty Alcohols / Q000737:chemistry / Q000378:metabolism; D005818:Genetic Engineering; D017434:Protein Structure, Tertiary
D005233:Fatty Alcohols; C005066:borrelidin