Reproduction of postweaning multisystemic wasting syndrome in pigs experimentally inoculated with a Swedish porcine circovirus 2 isolate.
In recent years, porcine circovirus type 2 (PCV2)-associated postweaning multisystemic wasting syndrome (PMWS) has been reported worldwide. However, to date, PMWS has not been reported in Sweden despite the demonstration of serum antibodies to a PCV2-like virus in Swedish pigs. This communication reports the experimental reproduction of clinical PMWS after inoculation of colostrum-deprived (CD) pigs, derived from a Northern Ireland herd, with an isolate of PCV2 virus recovered from a clinically normal Swedish pig that was necropsied in 1993. The clinical disease and histological lesions observed in CD pigs inoculated with this virus were indistinguishable from those observed in previous studies on CD pigs inoculated with a PCV2 virus isolate recovered from pigs with PMWS. These results highlight the disease potential of PCV2 isolated from regions apparently free of PMWS and suggest that the status of the host and its environment is an important factor in the development of clinical PMWS.
Allan
Gordon
G
Veterinary Sciences Division, Department of Agriculture and Rural Development, Belfast BT4 3SD, Northern Ireland, UK.
McNeilly
Francis
F
Meehan
Brian
B
McNair
Irene
I
Ellis
John
J
Krakowka
Steve
S
Fossum
Caroline
C
Wattrang
Eva
E
Wallgren
Per
P
Adair
Brian
B
D000818:Animals; D000831:Animals, Newborn; D001483:Base Sequence; D018173:Circoviridae Infections / Q000503:physiopathology / Q000662:veterinary*; D017925:Circovirus / Q000472:pathogenicity*; D004279:DNA, Viral / Q000032:analysis; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000662:veterinary; D013548:Sweden; D013553:Swine Diseases / Q000821:virology*; D019282:Wasting Syndrome / Q000662:veterinary*; D014886:Weaning
D004279:DNA, Viral