title: New developments in SPME, Part 1: The use of vapor-phase deprotonation and on-fiber derivatization with alkylchloroformates in the analysis of preparations containing amphetamines.
abstract: Due to their high polarity and low vapor pressure, most amine salts of amphetamine-type drugs are not directly amenable to headspace recovery using solid-phase microextraction (SPME). Described in this article is a simple vapor-phase procedure for the conversion of solid drug salt samples into their free bases by the use of triethylamine. This process can be conducted simultaneously with headspace SPME, the outcome being that solid drug salts can be sampled directly for GC-MS without the need for dissolution and chemical processing. Potential applications for this methodology include the noninvasive recovery of drug traces from objects such as banknotes and garments. This new process for recovery of amphetamine-type drugs has been combined with on-fiber derivatization using alkylchloroformates. This extra step was included to improve the chromatographic performance of analytes and allow for the resolution of drug enantiomers.
authors.affiliation: Flinders University of South Australia, GPO Box 2100, Adelaide, South Australia.
authors.forename: Hayley
authors.initials: H
authors.lastname: Brown
authors.forename: K Paul
authors.initials: KP
authors.lastname: Kirkbride
authors.forename: Paul E
authors.initials: PE
authors.lastname: Pigou
authors.forename: G Stewart
authors.initials: GS
authors.lastname: Walker
mesh_terms: D000662:Amphetamines / Q000737:chemistry / Q000302:isolation & purification*; D000697:Central Nervous System Stimulants / Q000302:isolation & purification*; D005554:Forensic Medicine / Q000379:methods; D005561:Formates; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D015394:Molecular Structure; D015813:Substance Abuse Detection / Q000379:methods
chemical_list: D000662:Amphetamines; D000697:Central Nervous System Stimulants; D005561:Formates