title: Acute electroretinographic changes during sildenafil (Viagra) treatment for erectile dysfunction.
abstract: The authors describe their findings on 12 subjects who were treated with 50 mg of sildenafil (Viagra) and underwent ERG measurements prior to and 1 hour after ingestion. The Naka-Rushton equation was used to describe the b-wave luminance-response function of the scotopic ERG. Statistically significant differences were noted in the Vmax and K values. Sildenafil ingestion resulted in an increase in Vmax (higher rod response to light stimuli) and a decrease in K (higher sensitivity).
authors.affiliation: Department of Ophthalmology, University of Rome La Sapienza, Rome, Italy. corrado.balacco@uniroma1.it
authors.forename: Corrado
authors.initials: C
authors.lastname: Balacco Gabrieli
authors.forename: Federico
authors.initials: F
authors.lastname: Regine
authors.forename: Enzo M
authors.initials: EM
authors.lastname: Vingolo
authors.forename: Edoardo
authors.initials: E
authors.lastname: Rispoli
authors.forename: Aldo
authors.initials: A
authors.lastname: Isidori
mesh_terms: D004596:Electroretinography; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects*; D010879:Piperazines / Q000009:adverse effects*; D011687:Purines; D012160:Retina / Q000187:drug effects* / Q000503:physiopathology*; D000068677:Sildenafil Citrate; D013450:Sulfones; D013997:Time Factors
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate