Ethnic differences in the relationship between fasting leptin and BMI in children.
OBJECTIVE
To compare the relationship between fasting serum leptin levels and body mass index (BMI) in children from different ethnic groups.


METHODS
Children aged 6-10 y from rural Gambia (n=471) and central Italy (n=839).


METHODS
Anthropometry (z-score of BMI) and fasting serum leptin concentrations.


RESULTS
The Italian children had significantly higher mean BMI z-scores than the Gambian children (males: Italy 1.58, Gambia -1.44, P< or =0.0001; females: Italy 1.33, Gambia -1.42, P< or =0.0001) and significantly higher serum leptin concentrations (males: Italy 8.86 ng ml(-1), Gambia 1.78 ng ml(-1), P< or =0.0001; females: Italy 11.31 ng ml(-1), Gambia 2.22 ng ml(-1), P< or =0.0001). A significantly different relationship was observed between z-score of BMI and serum leptin levels in the Gambian and the Italian children for both boys and girls.


CONCLUSIONS
A different relationship exists between z-score of BMI and leptin levels in these two groups of children from very diverse ethnic backgrounds. Future studies using detailed measures of body composition and energy balance are needed to help understand this relationship.
Moore
S E
SE
MRC International Nutrition Group, Public Health Nutrition Unit, London School of Hygiene and Tropical Medicine, London, UK. Sophie.Moore@LSHTM.ac.uk
Falorni
A
A
Bini
V
V
Fulford
A J C
AJ
O'Connell
M A
MA
Prentice
A M
AM
D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D002648:Child; D005260:Female; D005714:Gambia / Q000208:ethnology; D006801:Humans; D007558:Italy / Q000208:ethnology; D020738:Leptin / Q000097:blood*; D008297:Male; D012044:Regression Analysis; D012727:Sex Characteristics
D020738:Leptin