title: [Characteristics of distribution of nitric oxide synthase containing neurons in the medullary cardiovascular centers of dogs and rats].
abstract: The aim of the study was to characterize species-related differences in the distribution of nitric oxide synthase (NOS)-containing neurons in the medullary structures of dogs and rats involved in the regulation of the sympathetic or parasympathetic drives. Two main results have been obtained, namely: (i) the average number of NOS-containing neurons in the dorsomedial and ventrolateral medulla per section in dog was larger than that in rat, while the density of the positive cells in the both regions in dog was less than that in rat. (ii) Within the dorsal motor nucleus of vagus a lot of NOS-containing cells (preganglionic vagal neurons) were observed only in dog. Differences in the distribution of NO-generating neurons in the medullary cardiovascular centers, and heterogeneity in the basal level of NO release may contribute to the peculiarities of the hemodynamic responses induced by NOS inhibitors in these species.
authors.affiliation: A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
authors.forename: V V
authors.initials: VV
authors.lastname: Datsenko
authors.forename: V B
authors.initials: VB
authors.lastname: Pavliuchenko
authors.forename: O O
authors.initials: OO
authors.lastname: Moĭbenko
authors.forename: O I
authors.initials: OI
authors.lastname: Piliavs'kyĭ
authors.forename: O I
authors.initials: OI
authors.lastname: Kostiukov
authors.forename: V O
authors.initials: VO
authors.lastname: Maĭs'kyĭ
mesh_terms: D000344:Afferent Pathways; D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000294:innervation; D004285:Dogs; D005728:Ganglia, Sympathetic / Q000166:cytology / Q000201:enzymology / Q000502:physiology; D008297:Male; D008526:Medulla Oblongata / Q000166:cytology / Q000201:enzymology* / Q000502:physiology; D009475:Neurons, Afferent / Q000201:enzymology* / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D017552:Solitary Nucleus / Q000166:cytology / Q000201:enzymology / Q000502:physiology; D013045:Species Specificity; D014018:Tissue Distribution; D014630:Vagus Nerve / Q000166:cytology / Q000201:enzymology / Q000502:physiology
chemical_list: D019001:Nitric Oxide Synthase