INS VNTR is a QTL for the insulin response to oral glucose in obese children.
We performed a genotype-phenotype association study to examine whether the insulin VNTR (INS VNTR) polymorphism located in the insulin gene promoter was associated with changes in insulin response to oral glucose. Two classes of INS VNTR alleles are observed in Caucasians, the "short" class I and the "long" class III. Plasma insulin and glucose concentrations and indices of insulin secretion (IGI) and sensitivity (ISI) were measured using an oral glucose tolerance test (OGTT) in 387 obese children aged 12 +/- 0.1 yr with a mean body mass index (BMI) of 30.6 kg/m(2) (161% of the normal mean). During OGTT, plasma insulin and IGI were 20-30% higher in I/I obese children vs. III carriers (P < 0.01). A general linear model adjusting for age, sex, and puberty was also used to evaluate the influence of the VNTR genotype on the BMI-IGI (P = 0.07) and the BMI-ISI (P < 0.006) relationships. The INS VNTR can therefore be considered a quantitative trait locus influencing glucose-stimulated insulin physiology in obese juveniles.
Dos Santos
Christine
C
Department of Pediatric Endocrinology and Unité 561 Institut National de la Santé et de la Recherche Médicale, Hôpital Saint Vincent de Paul, René Descartes University, 75014 Paris, France.
Fallin
Daniele
D
Le Stunff
Catherine
C
LeFur
Sophie
S
Bougnères
Pierre
P
D000284:Administration, Oral; D000483:Alleles; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D015992:Body Mass Index; D002648:Child; D004032:Diet; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D005947:Glucose / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D000078790:Insulin Secretion; D016014:Linear Models; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics*; D009765:Obesity / Q000097:blood* / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D010641:Phenotype; D011627:Puberty; D040641:Quantitative Trait Loci / Q000235:genetics*; D044465:White People / Q000235:genetics
D001786:Blood Glucose; D005819:Genetic Markers; D007328:Insulin; D005947:Glucose