title: Prognostic value of heart rate variability in patients with hypertrophic cardiomyopathy.
abstract: Hypertrophic cardiomyopathy (HCM) have been reported to display impaired heart rate variability, although little is known regarding its prognostic value. By using fast Fourier transformation of 24-hour Holter recordings in 73 HCM patients at a stable clinical condition, we computed 4 spectral components: very low frequency, low frequency, high frequency, and total power. During 28 months, 7 HCM patients experienced death or acquired hospitalization for heart failure. Sudden death did not occurred. High frequency component was lower in HCM patients with cardiac events than that in patients without cardiac events (3.78 +/- 0.66 vs. 4.43 +/- 0.92 In(ms(2)), P =.045). There were no significant differences in other heart rate variability variables between HCM patients with and without cardiac events. In multivariate analysis, high frequency component remained to be an independent predictor of cardiac events (relative risk=0.10, 95% CI 0.01-0.73, P =.023). Heart rate variability analysis is predictive of heart failure in our cohort of HCM patients, whereas its predictive value of sudden death remains unclear.
authors.affiliation: Department of Cardiology, Matushita Memorial Hospital, Morigu-chi city, Osaka, Japan. js-k@wf6.so-net.ne.jp
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kawasaki
authors.forename: Akihiro
authors.initials: A
authors.lastname: Azuma
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Sakatani
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Hadase
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Kamitani
authors.forename: Shingo
authors.initials: S
authors.lastname: Kawasaki
authors.forename: Toshiro
authors.initials: T
authors.lastname: Kuribayashi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Sugihara
mesh_terms: D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D004452:Echocardiography; D015716:Electrocardiography, Ambulatory; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D012307:Risk Factors; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D013575:Syncope / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology
chemical_list: D000889:Anti-Arrhythmia Agents