Seizure outcome after temporal lobectomy in temporal lobe cortical dysplasia.
OBJECTIVE
To identify the temporal lobe cortical dysplasia (CD) histopathology classification subtype and determine the seizure outcome of patients who underwent temporal lobectomy with coincident CD.


METHODS
We reviewed the data of 28 patients with temporal lobe epilepsy who underwent surgery with pathologically verified CD at our institution from 1990 to 2000. The seizure outcome was assessed at a minimum of 1 year after surgery according to Engel's classification.


RESULTS
Of 28 patients who underwent surgery, nine (32.1%) had isolated CD, and 19 (67.9%) had CD and hippocampal sclerosis (CD&HS). Twenty-six (92.9%) patients had histopathology subtype Ia (architectural abnormalities). Twenty (71.4%) patients were seizure free (Engel class I). Favorable seizure outcome (Engel class I, II) was achieved in 26 (92.9%) patients. No difference in seizure outcome was noted between patients with CD and CD&HS.


CONCLUSIONS
The most common histopathologic subtype in patients with temporal lobe CD is type Ia (architectural abnormalities). Temporal lobectomy in temporal lobe epilepsy patients with CD can achieve favorable seizure outcome.
Srikijvilaikul
Teeradej
T
Department of Neurosurgery, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Najm
Imad M
IM
Hovinga
Collin A
CA
Prayson
Richard A
RA
Gonzalez-Martinez
Jorge
J
Bingaman
William E
WE
D000293:Adolescent; D000328:Adult; D038481:Anterior Temporal Lobectomy; D002648:Child; D002675:Child, Preschool; D003952:Diagnostic Imaging; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis* / Q000503:physiopathology; D012598:Sclerosis; D013702:Temporal Lobe / Q000002:abnormalities* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D016896:Treatment Outcome