title: Separate analysis of asialoglycoprotein receptors in the right and left hepatic lobes using Tc-GSA SPECT.
abstract: The asialoglycoprotein receptor (ASGPR) is abundantly expressed on the sinusoidal surfaces of hepatocytes. We aimed to clarify the clinical significance of the regional distribution of ASGPRs in the human liver, especially in chronic viral hepatitis. Eighteen volunteers, 34 patients with chronic hepatitis, and 33 patients with cirrhosis (11/Child-Pugh A, 11/Child-Pugh B, 11/Child-Pugh C) were studied using a newly developed, conventional technetium-99m-diethylenetriaminepentaacetic acid-galactosyl human serum albumin ((99m)Tc-GSA), single photon emission computed tomography (SPECT) method. Using Cantlie's line as a guide, ASGPR dynamics were analyzed separately in the right and left lobes, as well as in the whole liver, using novel indices (the liver uptake ratio [LUR] and the liver uptake density [LUD], which reflect the amount and density of ASGPRs in the liver, respectively). Mean LUR and LUD values for the whole liver and the right and left lobes decreased with increasing progression of chronic viral hepatitis. The LUR for the whole liver correlated well with parameters measuring the hepatic functional reserve and the platelet count. The right LUR correlated particularly well with conventional liver function tests, and comparison of the right LUD with histologic findings showed that it was a good indicator of periportal and/or bridging necrosis and fibrosis. In conclusion, our (99m)Tc-GSA SPECT method was clinically useful in evaluating regional hepatic function and the progression of chronic viral hepatitis using dynamic changes in ASGPRs.
authors.affiliation: Department of Internal Medicine and Molecular Therapeutics, Yamagata University School of Medicine, Yamagata, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sugahara
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Togashi
authors.forename: Kazuei
authors.initials: K
authors.lastname: Takahashi
authors.forename: Yuya
authors.initials: Y
authors.lastname: Onodera
authors.forename: Mai
authors.initials: M
authors.lastname: Sanjo
authors.forename: Keiko
authors.initials: K
authors.lastname: Misawa
authors.forename: Akihiko
authors.initials: A
authors.lastname: Suzuki
authors.forename: Tohru
authors.initials: T
authors.lastname: Adachi
authors.forename: Junitsu
authors.initials: J
authors.lastname: Ito
authors.forename: Kazuo
authors.initials: K
authors.lastname: Okumoto
authors.forename: Etsuko
authors.initials: E
authors.lastname: Hattori
authors.forename: Tadashi
authors.initials: T
authors.lastname: Takeda
authors.forename: Hisayoshi
authors.initials: H
authors.lastname: Watanabe
authors.forename: Koji
authors.initials: K
authors.lastname: Saito
authors.forename: Takafumi
authors.initials: T
authors.lastname: Saito
authors.forename: Yukio
authors.initials: Y
authors.lastname: Sugai
authors.forename: Sumio
authors.initials: S
authors.lastname: Kawata
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D037263:Asialoglycoprotein Receptor / Q000032:analysis*; D018450:Disease Progression; D005260:Female; D006521:Hepatitis, Chronic / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000737:chemistry* / Q000000981:diagnostic imaging; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D037263:Asialoglycoprotein Receptor; D013668:Technetium Tc 99m Aggregated Albumin; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; D016284:Technetium Tc 99m Pentetate