Role of ion channels in mechanisms controlling gastrointestinal pain pathways.
Hypersensitivity or sensitization of nociceptive primary afferents in the gastrointestinal tract has been proposed as a mechanism for organic and functional gastrointestinal pain. This hypersensitivity can be the result of alterations, either induced by a sensitizing agent or without a peripheral cause, in the functional properties of ion channels located in primary afferents. The tetrodotoxin-resistent sodium channel, known as Na(v)1.8, is present in nociceptive primary afferents, including those from the gut, and it has been implicated as being the main candidate for the enhanced activity that characterizes nociceptor sensitization. Other voltage-gated channels, such as calcium and potassium channels, can also contribute to the sensitization of primary afferents observed in gastrointestinal pain states.
Cervero
Fernando
F
Anaesthesia Research Unit, McGill University, McIntyre Medical Building, Room 1207, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y6 Canada. fernando.cervero@mcgill.ca
Laird
Jennifer M A
JM
D000818:Animals; D015220:Calcium Channels / Q000378:metabolism / Q000502:physiology; D017615:Enteric Nervous System / Q000378:metabolism / Q000503:physiopathology; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000503:physiopathology*; D015640:Ion Channel Gating; D007473:Ion Channels / Q000378:metabolism / Q000502:physiology*; D009619:Nociceptors / Q000378:metabolism / Q000502:physiology; D010146:Pain / Q000503:physiopathology*; D015221:Potassium Channels / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction; D015222:Sodium Channels / Q000378:metabolism / Q000502:physiology; D017833:Visceral Afferents / Q000378:metabolism
D015220:Calcium Channels; D007473:Ion Channels; D015221:Potassium Channels; D015222:Sodium Channels