[Type I diabetes: an enteropathy?].
In the animal model of type-1 diabetes found in BioBreeding rats, an enteropathy characterized by morphological, biochemical and functional features precedes the autoimmune insulitis, and both lesions are modulated in their severity by dietary factors. Alterations of the intestinal mucin content, of gut permeability and of the information transfer between intestinal GLP-1 and its islet receptors, may link this enteropathy to the islet pathology.
Malaisse
W J
WJ
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000209:etiology*; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications* / Q000378:metabolism