[Inhibitive effect of soybean isoflavone on prostate hyperplasia in rats].
OBJECTIVE
To explore the inhibitive effect of soybean isoflavone on benign prostatic hyperplasia in rats.


METHODS
By subcutaneously injecting testosterone propionate to induce prostate hyperplasia in rats, the changes of prostate wet weight, prostatic index, morphological change, prostate-specific acid phosphatase (PAP), acid phosphatase in the control, the model, low, moderate, high dose of soybean isoflavone groups were observed.


RESULTS
The ventral prostate wet weight, prostatic index, and PAP in the low, moderate, and high dose groups were significantly lower than those in the models (P < 0.05). The ventral prostate wet weight, prostatic index, and PAP in the moderate, and high dose groups were significantly lower than those in the low dose group (P < 0.05).


CONCLUSIONS
Soybean isoflavone inhibits prostate hyperplasia and the increase of acid phosphatase and PAP in a dose-dependent manner in rats. Soybean isoflavone may serve as supplementary therapy and prevent benign prostatic hyperplasia.
Ren
Guo-feng
GF
Department of Nutrition and Food Hygiene, School of Public Health, Central South University, Changsha 410078, China.
Huang
Yi-ming
YM
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003864:Depression, Chemical; D007529:Isoflavones / Q000494:pharmacology*; D008297:Male; D048789:Phytoestrogens; D028321:Plant Preparations / Q000494:pharmacology*; D011470:Prostatic Hyperplasia / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology*; D029584:Prostatic Secretory Proteins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013025:Glycine max / Q000737:chemistry*; D043343:Testosterone Propionate
D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; D029584:Prostatic Secretory Proteins; D000135:Acid Phosphatase; D043343:Testosterone Propionate