title: Bone turnover markers and PTH levels in surgical versus natural menopause.
abstract: In order to assess similarities and differences in women that suffer surgical versus natural menopause, a series of bone, clinical, and biochemical parameters was assayed in a clinical sample of 35 women with surgical menopause and 112 women with natural menopause. Biochemical parameters included hormones [parathyroid hormone (PTH) and the sex steroids estradiol and testosterone] and several markers of bone turnover measured in urine (N-telopeptide and calcium/creatinine ratio) or serum (osteocalcin, total alkaline phosphatase, total and ionic calcium, phosphate, and magnesium). In addition to type of menopause, women were divided by years since menopause (ysm </= 2 or >2). To detect differences and relationships between variables, ANOVA, ANCOVA, and linear regression analyses were used. Only N-telopeptide, one resorption marker, was significantly affected by the variable years since menopause </=2 or >2 ( P <0.01), but not by type of menopause. The age-corrected level of PTH was significantly decreased in the surgical menopause group ( P < 0.05). In conclusion, type of menopause did not impose significant differences in bone turnover markers. PTH, one powerful resorption hormone, was diminished in surgical menopause.
authors.affiliation: Research Unit, Hospital Clínico Universitario de Valencia, Valencia, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: García-Pérez
authors.forename: J
authors.initials: J
authors.lastname: Moreno-Mercer
authors.forename: J J
authors.initials: JJ
authors.lastname: Tarín
authors.forename: A
authors.initials: A
authors.lastname: Cano
mesh_terms: D015502:Absorptiometry, Photon; D015415:Biomarkers / Q000032:analysis*; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism; D003094:Collagen / Q000652:urine; D024042:Collagen Type I; D005260:Female; D006801:Humans; D008594:Menopause, Premature / Q000097:blood* / Q000652:urine*; D008875:Middle Aged; D010012:Osteogenesis / Q000502:physiology*; D010281:Parathyroid Hormone / Q000097:blood*; D010455:Peptides / Q000652:urine
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010281:Parathyroid Hormone; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D003094:Collagen