title: [Genetic differentiation of residents of Central Asia from autosomal marker data].
abstract: The gene pool of five ethnic groups of the Central Asian population was characterized using nine human-specific polymorphic insertion/deletion loci (ACE, PLAT, APOA1, PV92, F13B, A25, B65, CD4, Mt-Nuc). It has been shown for the first time that at the CD4 locus, the frequency of Alu(-) is inversely related to the Mongoloid component of the population. For the Central Asian populations, the lowest and highest frequencies of the Alu deletion at locus CD4 were recorded respectively in Dungans (0.04), immigrants from China, and Tajiks (0.15). The coefficient of gene differentiation in the Central Asian populations for all the genes was 2.8%, which indicates a relatively low level of population genetic subdivision in this region. The unity of the gene pool of the Central Asian Caucasoids was shown.
authors.affiliation: Research Institute of Medical Genetics, Tomsk Research Center, Russian Academy of Medical Sciences, Tomsk, 634050 Russia.
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Khitrinskaia
authors.forename: V A
authors.initials: VA
authors.lastname: Stepanov
authors.forename: V P
authors.initials: VP
authors.lastname: Puzyrev
authors.forename: M G
authors.initials: MG
authors.lastname: Spiridonova
authors.forename: M I
authors.initials: MI
authors.lastname: Voevoda
mesh_terms: D000483:Alleles; D001208:Asia; D005787:Gene Frequency; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans
chemical_list: D005819:Genetic Markers