Interleukin-8 expressed in the granulocytes of the eye in a patient with Behçet's disease complicated by lens-induced endophthalmitis.
BACKGROUND
Interleukin-8 (IL-8) is believed to be involved in the progression of intraocular inflammation. We sought the source of IL-8 in the enucleated eye of the present patient.


METHODS
A 40-year-old Japanese man was diagnosed as having Behçet's disease. His vision deteriorated due to persistent uveitis and secondary glaucoma. His left eye had lens-induced endophthalmitis.


METHODS
The left eye had to be enucleated, and it was investigated by an immunohistochemical analysis using antibodies for CD 1a (dendritic cells), CD 3 (T cells), CD 68 (monocytes/macrophages), interferon-gamma, or IL-8. Fibrovascular tissue had formed on and beneath the lens where inflammatory cells had infiltrated. Most of the mononuclear inflammatory cells were T cells. A large number of macrophages were observed especially around the lens. Interferon-gamma-positive cells were scattered, while IL-8 was observed only in the accumulated granulocytes, but not in either mononuclear cells or macrophages.


CONCLUSIONS
IL-8 is thus considered to play a role in the progression of intraocular inflammation, and granulocytes are thought to be a possible source of IL-8 in endophthalmitis.
Sakamoto
Hidehisa
H
Department of Ophthalmology, Kyushu University, Graduate School of Medicine, Fukuoka, Japan.
Sakamoto
Taiji
T
Kubota
Toshiaki
T
Duan
Hong
H
Koga
Tetsuya
T
Furue
Masutaka
M
Ishibashi
Tatsuro
T
D000328:Adult; D001528:Behcet Syndrome / Q000150:complications / Q000378:metabolism* / Q000473:pathology*; D009877:Endophthalmitis / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D005128:Eye Diseases / Q000150:complications*; D015353:Eye Enucleation; D006098:Granulocytes / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D016209:Interleukin-8 / Q000378:metabolism*; D007908:Lens, Crystalline; D008297:Male
D016209:Interleukin-8