title: Proton MR spectroscopy in neuroborreliosis: a preliminary study.
abstract: We report results of a magnetic resonance spectroscopy (MRS) study in 12 patients with neuroborreliosis. We used a PRESS sequence, placing an 8 cm3 voxel in normal-appearing white matter of the frontal lobe. Peaks indicating N-acetylaspartate (NAA), choline (Cho), creatine (Cr), myo-inositol (mI), lipids (Lip) and lactate (Lac) were identified and ratios of NAA/Cr, Cho/Cr, mI/Cr, Lip/Cr, Lac/Cr calculated. Significant increases in Cho/Cr and Lip/Cr were noted. No abnormality was found in mean NAA/Cr and Lac/Cr, but in four patients there was a decreased NAA peak; mI/Cr ratio was slightly increased. Although the spectroscopic profile in patients with neuroborreliosis seems to be nonspecific, MRS might be useful for assessing tissue damage of the central nervous system.
authors.affiliation: Department of Radiology, Medical Academy, Bialystok, Poland. ambau@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Ustymowicz
authors.forename: E
authors.initials: E
authors.lastname: Tarasów
authors.forename: J
authors.initials: J
authors.lastname: Zajkowska
authors.forename: J
authors.initials: J
authors.lastname: Walecki
authors.forename: T
authors.initials: T
authors.lastname: Hermanowska-Szpakowicz
mesh_terms: D000328:Adult; D000368:Aged; D001927:Brain Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D020852:Lyme Neuroborreliosis / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011522:Protons
chemical_list: D011522:Protons