The thyroid hormone receptor beta gene: structure and functions in the brain and sensory systems.
Thyroid hormone profoundly influences the development of the vertebrate nervous system. The thyroid hormone receptor beta gene (Thrb) is a key mediator of many of these actions. The Thrb gene is complex, spanning up to 400 kb in mammals, and differentially expresses distinct receptor subtypes through independent tissue-specific promoters and alternative splicing. These receptors serve a range of functions in the brain as well as particularly sensitive functions in the auditory and visual sensory systems. The Thrb gene illustrates how versatility in neurodevelopmental control can be achieved at the receptor level.
Jones
Iwan
I
Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA.
Srinivas
Maya
M
Ng
Lily
L
Forrest
Douglas
D
D000818:Animals; D001921:Brain / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D051379:Mice; D009154:Mutation; D010641:Phenotype; D051381:Rats; D011988:Receptors, Thyroid Hormone / Q000235:genetics*; D037042:Thyroid Hormone Receptors beta
D011988:Receptors, Thyroid Hormone; D037042:Thyroid Hormone Receptors beta