[Inhibiting effect of EGFR monoclonal antibody on proliferation of oral squamous cell carcinoma].
OBJECTIVE
To investigate the inhibiting effect of epidermal growth factor receptor (EGFRmAb) on proliferation of oral squamous cell carcinoma (SCC).


METHODS
Tca8113 squamous cell carcinoma cell line was treated with different concentration of EGFRmAb. Cell growth curve, clone inhibition rate, cell cycle redistribution and the expression of p27kip1 were analyzed.


RESULTS
EGFRmAb inhibited proliferation of oral SCC, leaded to elevation of cell proportion of G1phase cell, decreased the proportion of S phase cell and upregulated the express of p27kip1.


CONCLUSIONS
EGFRmAb inhibited the proliferation of oral SCC, which related with G1 phase arrest of tumor cell.
Wang
Ming-guo
MG
Dept. Of Oral & Maxillofacial Surgery, School of Stomatology, Shanghai Second Medical University, Shanghai 200011, China. wmgsh@163.com
Wang
Zhong-he
ZH
Hu
Hai-sheng
HS
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000235:genetics; D002455:Cell Division; D050760:Cyclin-Dependent Kinase Inhibitor p27; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D006801:Humans; D009062:Mouth Neoplasms / Q000473:pathology / Q000628:therapy*; D012333:RNA, Messenger / Q000032:analysis; D025521:Tumor Suppressor Proteins / Q000235:genetics
D000911:Antibodies, Monoclonal; D018797:Cell Cycle Proteins; D012333:RNA, Messenger; D025521:Tumor Suppressor Proteins; D050760:Cyclin-Dependent Kinase Inhibitor p27; D066246:ErbB Receptors