[Differences in prooxidant effect of neuroleptics haloperidol and aminazine].
In the in vitro experiments with hydrobiont Daphnia magna Straus as the test-object the comparative evaluation of the prooxydant activity of two neuroleptics galoperidol and aminazine, was performed. It was shown that galoperidol possesses the pronounced prooxydant activity compared with hydrogen peroxyde. Aminazine didn't display such an action. The exogenios reduced glutathione is capable to protect Daphnia from the prooxydant action of galoperidol may be used for the investigation of anti- and prooxydant effects of toxicants and medicines in vivo.
Podosinovikova
N P
NP
Department of Biochemistry, Department of Toxicology, Institute of Toxicology Ministry of Health of Russia, 193019, St.-Petersburg, Bekhterev str. 1.
Petrov
V V
VV
Kosmachev
A B
AB
Kubarskaia
L G
LG
Dagaev
S G
SG
Dolgo-Saburov
V B
VB
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002746:Chlorpromazine / Q000633:toxicity*; D003621:Daphnia / Q000187:drug effects*; D006220:Haloperidol / Q000633:toxicity*; D006861:Hydrogen Peroxide / Q000633:toxicity; D007928:Lethal Dose 50; D016877:Oxidants / Q000633:toxicity*
D000975:Antioxidants; D016877:Oxidants; D006861:Hydrogen Peroxide; D006220:Haloperidol; D002746:Chlorpromazine