Antibacterial and antiproliferative activity of cationic fullerene derivatives.
We examined the antibacterial and antiproliferative activities of alkylated C(60)-bis(N,N-dimethylpyrrolidinium iodide) derivatives. The fullerene derivatives inhibited bacteria and cancer cell growth effectively. However, the fullerene derivatives with a long alkyl chain did not show antibacterial activity.
Mashino
Tadahiko
T
Kyoritsu College of Pharmacy, Shibakoen 1-5-30, Minato-ku, Tokyo 105-8512, Japan. mashino-td@kyoritsu-ph.ac.jp
Nishikawa
Dai
D
Takahashi
Kyoko
K
Usui
Noriko
N
Yamori
Takao
T
Seki
Masako
M
Endo
Toyoshige
T
Mochizuki
Masataka
M
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D037741:Fullerenes