title: [Extraprostatic disease prediction in patients with carcinoma of the prostate: role of PSA, prostatic biopsy fragments percentage and Gleason score].
abstract: OBJECTIVE
  To valuate the behavior of the prostatic biopsy fragments percentage, guided by transrectal ultrasonography in extraprostatic disease prediction in patients with localized adenocarcinoma of the prostate gland and, also, to compare the efficiency of this pattern with them got by the valuation of PSA and preoperative Gleason score.
  
  
  METHODS
  This retrospective non-controlled study consisted of 522 patients with adenocarcinoma located in the prostate. They were submitted to surgical treatment through retropubic radical prostatectomy. The ages of the patients ranged from 42 to 76 years with a mean of 62.44 years. All of them were submitted to transrectal ultrasonography with prostatic biopsy (direct of the lesion and/or suspected area and sextant) previous to the radical surgical treatment. The 522 patients were divided in groups according to the positive fragments found by the biopsy, what was correlated with the anatomicpathologic findings of intraprostatic disease (limited to the gland) and extraprostatic (invasion periprostatic adiposity and/or the bladder neck and/or the seminal vesicles and/or positive pelvic lymph nodes) of the surgical specimen.
  
  
  RESULTS
  Regarding the analysis of the positive fragments percentage, the groups G1 (0-25%), G2 (20-50%) and G3 (51-75%) showed an incidence of the intraprostatic disease two and three times greater than the extraprostatic one. However, when more than 75% of the biopsy fragments were positive (G4, 76-100%), the relation inverted occurring a predominance of the extraprostatic disease over the intraprostatic. In this group 56.98% of the patients showed extraprostatic disease. There was a statistically significant difference of the extraprostatic disease between the groups G3 and G4 (p 0.0068).
  
  
  CONCLUSIONS
  When we compared the three inconstant to evaluate the efficiency order anticipating extraprostatic disease, we verified that the preoperative PSA was the most discriminated (p = 0.000000) followed by the Gleason score of prostatic biopsy (p = 0.000003) and by the positive biopsies percentage (p = 0.000574).
authors.affiliation: Universidad Federal de São Paulo, Escola Paulista de Medicina, São Paulo, SP, Brasil.
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Calvete
authors.forename: Miguel
authors.initials: M
authors.lastname: Srougi
authors.forename: Luciano Jo o
authors.initials: LJ
authors.lastname: Nesrallah
authors.forename: Marcos Francisco
authors.initials: MF
authors.lastname: Dall'Oglio
authors.forename: Valdemar
authors.initials: V
authors.lastname: Ortiz
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D017430:Prostate-Specific Antigen