Inhibitory effects of 3-O-acyl-(+)-catechins on Epstein-Barr virus activation.
In the course of an exploratory investigation of antitumor-promoting catechins, 3-O-acyl-(+)-catechins of varying carbon lengths from C(4) to C(18) were assessed for inhibitory effects on the activation of the Epstein-Barr virus early antigen. Like 3-O-acyl-(-)-epigallocatechins, the (+)-catechin derivatives showed promising effects with the C-3 acyl chain of C(8)-C(11) carbon atoms.
Uesato
Shinichi
S
Department of Biotechnology, Faculty of Engineering, Kansai University, Suita, Osaka, Japan. uesato@ipcku.kansai-u.ac.jp
Taniuchi
Keisuke
K
Kumagai
Ayako
A
Nagaoka
Yasuo
Y
Seto
Ryota
R
Hara
Yukihiko
Y
Tokuda
Harukuni
H
Nishino
Hoyoku
H
D000956:Antigens, Viral / Q000378:metabolism*; D002392:Catechin / Q000737:chemistry* / Q000494:pharmacology*; D002460:Cell Line; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D014775:Virus Activation / Q000187:drug effects*
D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D002392:Catechin