Coumarin-4-ylmethoxycarbonyls as phototriggers for alcohols and phenols.
Caged compounds can be used to regulate the spatial and temporal dynamics of signaling molecules in live cells. Photochemical properties of coumarin-4-ylmethoxy carbonates (1a-d) are investigated to construct caged compounds of hydroxy-containing molecules. All the compounds possess desired properties as phototriggers for alcohols and phenols. The 6-bromo-7-hydroxycoumarin-4-ylmethoxycarbonyl (Bhcmoc) group has the highest photochemical efficiency and is applied to make caged compounds of 1,2-dioctanoylglycerol (diC(8)), Tyr-OMe, and adenosine. [reaction: see text]
Suzuki
Akinobu Z
AZ
Department of Biomolecular Science, Toho University, 2-2-1 Miyama, Funabashi, 274-8510 Japan.
Watanabe
Takayoshi
T
Kawamoto
Mika
M
Nishiyama
Keiko
K
Yamashita
Hirotaka
H
Ishii
Megumi
M
Iwamura
Michiko
M
Furuta
Toshiaki
T