title: Effects of 9-cis- and all-trans-retinoic acids on blood glucose homeostasis in the fiddler crab, Uca pugilator.
abstract: 9-cis-Retinoic acid (9CRA) and all-trans-retinoic acid (ATRA) are known to be involved in the regulation of glucose homeostasis in vertebrates by inducing insulin release and expression of glucose transporter proteins. In view of the fact that both 9CRA and ATRA are endogenous to the fiddler crab, Uca pugilator, that a retinoid X receptor exists in this fiddler crab and that activities of insulin-like and insulin-like growth factor-like peptides have been reported for crustaceans, we investigated whether 9CRA and ATRA also play a role in glucose homeostasis in U. pugilator. Neither 9CRA nor ATRA was found to produce hypoglycemic effects at a dose of 10 microg/g live mass. However, 9CRA, but not ATRA, induced hyperglycemia. Such 9CRA-induced hyperglycemia was apparently mediated by the eyestalk hormone CHH since injection of 9CRA into eyestalk-ablated crabs did not result in hyperglycemia. ATRA was found to have an inhibitory effect on the recovery of blood glucose concentration following ATRA administration. Discussion on the possible mechanisms for the actions of 9CRA and ATRA was presented.
authors.affiliation: Department of Biological Sciences, Nicholls State University, Highway 1, Thibodaux, LA 70310, USA. biol-ez@nicholls.edu
authors.forename: Enmin
authors.initials: E
authors.lastname: Zou
authors.forename: Ryan
authors.initials: R
authors.lastname: Bonvillain
mesh_terms: D000818:Animals; D060829:Arthropod Proteins; D001786:Blood Glucose / Q000187:drug effects* / Q000502:physiology; D003386:Brachyura / Q000502:physiology*; D005123:Eye / Q000378:metabolism; D006706:Homeostasis / Q000187:drug effects* / Q000502:physiology; D006943:Hyperglycemia / Q000139:chemically induced; D007447:Invertebrate Hormones; D009419:Nerve Tissue Proteins / Q000378:metabolism; D013508:Ophthalmologic Surgical Procedures; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D060829:Arthropod Proteins; D001786:Blood Glucose; D007447:Invertebrate Hormones; D009419:Nerve Tissue Proteins; C015947:hyperglycemic hormone, crustacean; C105492:9,13-retinoic acid; D014212:Tretinoin