ENTH/ANTH proteins and clathrin-mediated membrane budding.
The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. Structural analyses and ligand-binding studies have shown that a set of proteins previously designated as harboring an ENTH domain in fact contain a highly similar, yet unique module referred to as an AP180 N-terminal homology (ANTH) domain. ENTH and ANTH (E/ANTH) domains bind both inositol phospholipids and proteins and contribute to the nucleation and formation of clathrin coats on membranes. ENTH domains also function in the development of membrane curvature through lipid remodeling during the formation of clathrin-coated vesicles. E/ANTH-bearing proteins have recently been shown to function with adaptor protein-1 and GGA adaptors at the trans-Golgi network, which suggests that E/ANTH domains are universal components of the machinery for clathrin-mediated membrane budding.
Legendre-Guillemin
Valerie
V
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada.
Wasiak
Sylwia
S
Hussain
Natasha K
NK
Angers
Annie
A
McPherson
Peter S
PS
D033942:Adaptor Proteins, Vesicular Transport; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002966:Clathrin / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D008561:Membrane Fusion / Q000502:physiology*; D008563:Membrane Lipids / Q000378:metabolism; D008958:Models, Molecular; D034041:Monomeric Clathrin Assembly Proteins / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009479:Neuropeptides / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D011485:Protein Binding; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D033921:Vesicular Transport Proteins
D033942:Adaptor Proteins, Vesicular Transport; C475910:CLINT1 protein, human; D002352:Carrier Proteins; D002966:Clathrin; D008563:Membrane Lipids; D034041:Monomeric Clathrin Assembly Proteins; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D010716:Phosphatidylinositols; D033921:Vesicular Transport Proteins; C439023:clathrin assembly protein AP180; C114154:epsin; C097702:synaptojanin; D010744:Phosphoric Monoester Hydrolases