In vitro antigiardial activity of IRE-6A and IRE-7B, two ethyl-phenylcarbamate derivatives.
Resistance is a practical problem associated to the use of benzimidazoles in the antigiardial therapy. Since benzimidazole-resistant strains of fungi have shown increased sensitivity to phenylcarbamates, in this study we synthesized and in vitro tested novel substituted phenylcarbamates against the protozoa Giardia intestinalis. IRE-6A and IRE-7B, two 4-R-ethyl-phenylcarbamates demonstrated an important antigiardial activity although that was modest when compared to albendazole in axenic cultures of Giardia intestinalis. Results of this study suggest a potential role of phenylcarbamates as alternative to benzimidazoles in the therapy of giardiasis.
Jiménez-Cardoso
Enedina
E
Hospital Infantil de México, SSA.
Flores-Luna
Andrés
A
Angeles
E
E
Martínez
P
P
López-Castañares
R
R
Castañeda-Hernández
G
G
Pérez-Urizar
José
J
D015766:Albendazole / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002219:Carbamates / Q000494:pharmacology*; D016829:Giardia lamblia / Q000187:drug effects*
D000981:Antiprotozoal Agents; D002219:Carbamates; C481945:IRE-6A; C481946:IRE-7B; D015766:Albendazole