Roles of reproductive corticotropin-releasing hormone.
Corticotropin-releasing hormone (CRH), the principal regulator of the hypothalamic-pituitary-adrenal axis, as well as its receptors, have been identified in most female reproductive tissues, including the uterus, placenta, and ovary. Endometrial CRH may participate in decidualization, implantation, and early maternal tolerance; placental CRH may participate in the physiology of pregnancy and the onset of parturition, and ovarian CRH may participate in follicular maturation, ovulation, and luteolysis. The hypercortisolism of the latter half of pregnancy can be explained by increased levels of placental CRH in plasma. This hypercortisolism is followed by a transient suppression of hypothalamic CRH secretion in the postpartum period, which may explain the blues or depression and autoimmune phenomena frequently observed during this period.
Kalantaridou
Sophia N
SN
Department of Obstetrics and Gynecology, University of Ioannina Medical School, University Hospital, Panepistimiou Avenue, 45500 Ioannina, Greece. kalantas@exchange.nih.gov
Makrigiannakis
Antonis
A
Mastorakos
George
G
Chrousos
George P
GP
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D010064:Embryo Implantation; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008597:Menstrual Cycle / Q000502:physiology; D036801:Parturition / Q000502:physiology*; D010913:Pituitary-Adrenal System / Q000502:physiology*; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D012098:Reproduction / Q000502:physiology*; D012680:Sensitivity and Specificity
D003346:Corticotropin-Releasing Hormone