Acanthamoeba keratitis as a complication of orthokeratology.
OBJECTIVE
To present four cases of Acanthamoeba keratitis as a complication of orthokeratology.


METHODS
Observational case report.


METHODS
Four patients with Acanthamoeba keratitis had histories of overnight orthokeratology lens wear of 6 months to 2 years.


RESULTS
Three cases were diagnosed with Acanthamoeba keratitis by corneal scraping and one by confocal microscopy examination. The patients were treated with chlorhexidine, metronidazole, and neomycin sulfate, resulting in a rapid resolution of ocular inflammation.


CONCLUSIONS
Overnight wear of orthokeratology lenses may induce Acanthamoeba keratitis.
Xuguang
Sun
S
Department of Eye Microbiology, Beijing Institute of Ophthalmology, TongRen Hospital, Beijing, China. sunxuguang@yahoo.com
Lin
Chen
C
Yan
Zhang
Z
Zhiqun
Wang
W
Ran
Li
L
Shiyun
Luo
L
Xiuying
Jin
J
D000048:Acanthamoeba / Q000302:isolation & purification; D015823:Acanthamoeba Keratitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use; D002710:Chlorhexidine / Q000627:therapeutic use; D003261:Contact Lenses / Q000009:adverse effects*; D003315:Cornea / Q000469:parasitology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D009216:Myopia / Q000628:therapy; D009355:Neomycin / Q000627:therapeutic use
D000890:Anti-Infective Agents; D008795:Metronidazole; D009355:Neomycin; D002710:Chlorhexidine