Effect of regulatory peptides on gene transcription.
Experimental studies of geroprotective activity of synthetic oligopeptides and conformational analysis of the tetrapeptide Epithalon allowed us to hypothesize that regulatory oligopeptides directly initiate transcription of genes for vitally important proteins. Sequences of nucleotide pairs that can serve as binding sites for tetrapeptide Epithalon were identified in the promoter regions of retinal genes F379, telomerase, and RNA polymerase II.
Khavinson
V Kh
VKh
St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences. khavinson@gerontology.ru
Shataeva
L K
LK
Chernova
A A
AA
D000818:Animals; D004247:DNA / Q000737:chemistry; D004268:DNA-Binding Proteins / Q000737:chemistry; D006860:Hydrogen Bonding; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D011487:Protein Conformation; D012319:RNA Polymerase II / Q000737:chemistry; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D012984:Software; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D009842:Oligopeptides; D010455:Peptides; D004247:DNA; D012319:RNA Polymerase II; C421253:alanyl-glutamyl-aspartyl-glycine