title: The application of serial MRI analysis techniques to the study of cerebral atrophy in late-onset dementia.
abstract: We have used a serial MR image analysis technique previously developed for studies of cerebral atrophy in early-onset dementia and applied it to a study of late-onset dementia patients with images acquired using a different scanner and scan sequence. Validation and optimisation tests showed that with only small changes to key analysis parameters the technique can successfully be applied to previously untested data with dissimilar image characteristics. The overall accuracy in estimation of cerebral atrophy using the technique was determined to be between 2 and 4 ml (1sigma) depending on the conditions during image acquisition. By comparing the results of alternative registration techniques we demonstrate the potential of using of fully automated 9 DOF image registration as an effective and efficient means of correcting for scanner pixel size variations, even in the presence of significant cerebral atrophy. Applied to the late-onset dementia study, patients were found to have significantly increased mean atrophy rates (p<0.001) compared to controls. In general the analysis technique is shown to be a robust, accurate and transferable tool of potential value for future studies of dementia and related neuro-degenerative disorders.
authors.affiliation: Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK. S.M.paling@shef.ac.uk
authors.forename: S M
authors.initials: SM
authors.lastname: Paling
authors.forename: E D
authors.initials: ED
authors.lastname: Williams
authors.forename: R
authors.initials: R
authors.lastname: Barber
authors.forename: E J
authors.initials: EJ
authors.lastname: Burton
authors.forename: W R
authors.initials: WR
authors.lastname: Crum
authors.forename: N C
authors.initials: NC
authors.lastname: Fox
authors.forename: J T
authors.initials: JT
authors.lastname: O'Brien
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D000544:Alzheimer Disease / Q000175:diagnosis; D001284:Atrophy / Q000175:diagnosis; D002540:Cerebral Cortex / Q000473:pathology*; D003704:Dementia / Q000175:diagnosis*; D015140:Dementia, Vascular / Q000175:diagnosis; D018450:Disease Progression; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D020961:Lewy Body Disease / Q000175:diagnosis; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D013382:Subtraction Technique