title: Experience improves successful use of fibrin sealant in total knee arthroplasty: implications for surgical education.
abstract: This study evaluating fibrin sealant application in total knee arthroplasty (TKA) found significant differences in the decline in adjusted hemoglobin loss at 48 hours postoperatively in the treatment group (FS) relative to the control group (C) when the groups were segregated into early and late subgroups. The decline between the late C, 3.53 +/- 0.22 g/dL, and the late FS, 3.01 +/- 0.20 g/dL, was 0.52 g/dL (p = 0.04). The decline between the early C, 3.51 +/- 0.21 g/dL, and the early FS, 3.25 +/- 0.22 g/dL, was 0.26 g/dL (p = 0.34). This study demonstrates the importance of experience and education in successful application of tissue adhesives.
authors.affiliation: Department of Orthopaedic Surgery, University of Virginia, Charlottesville, Virginia, USA.
authors.forename: Gwo-Jaw
authors.initials: GJ
authors.lastname: Wang
authors.forename: Charles A
authors.initials: CA
authors.lastname: Goldthwaite
authors.forename: Sandra G
authors.initials: SG
authors.lastname: Burks
authors.forename: William D
authors.initials: WD
authors.lastname: Spotnitz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D003710:Demography; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D013502:General Surgery / Q000193:education*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D016037:Single-Blind Method
chemical_list: D015718:Fibrin Tissue Adhesive