[Study on the effects of curcumin on angiogenesis].
OBJECTIVE
The effects of curcumin on angiogenesis were studied.


METHODS
Proliferation of bovine aortic endothelial cells (BAECs) and cells of human cancerous cell line SGC-7901 were measured by MTT colorimetric assay after treated by various concentrations of curcumin. The effects of curcumin on BAECS proliferation promoted by tumor conditioned medium were observed by MTT colorimetric assay. The effects of various concentration of curcumin on the migration of BAECs and migration promoted by tumor conditioned medium were investigated by agorose assay.


RESULTS
Curcumin can obviously inhibit the proliferation of BAECs induced by fetal bovine serum (FBS) and tumor conditioned medium. Curcumin can also obviously inhibit the migration of BAECs induced by FBS and tumor conditioned medium.


CONCLUSIONS
Curcumin can inhibit angiogenesis by preventing proliferation and migration of endothelial cells. It also suggestes that curcumin is one kind of specific inhibitors of angiogenesis.
Gao
Chengxian
C
Molecular Medical Institute, Zhejiang College of Traditional Chinese Medicine, Hangzhou 310053.
Ding
Zhishan
Z
Liang
Bingbing
B
Chen
Nipi
N
Cheng
Dongqing
D
D000230:Adenocarcinoma / Q000098:blood supply; D020533:Angiogenesis Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000166:cytology; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D002478:Cells, Cultured; D030024:Curcuma / Q000737:chemistry; D003474:Curcumin / Q000302:isolation & purification / Q000494:pharmacology*; D042783:Endothelial Cells / Q000187:drug effects*; D004730:Endothelium, Vascular / Q000166:cytology; D006801:Humans; D009389:Neovascularization, Pathologic / Q000473:pathology*; D010946:Plants, Medicinal / Q000737:chemistry; D013274:Stomach Neoplasms / Q000098:blood supply; D014407:Tumor Cells, Cultured
D020533:Angiogenesis Inhibitors; D003474:Curcumin