title: Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice.
abstract: Interleukin-17 is a T cell-derived proinflammatory cytokine. This cytokine is suspected to be involved in the development of rheumatoid arthritis (RA) because this cytokine expression is augmented in synovial tissues of RA patients. The pathogenic roles of IL-17 in the development of RA, however, still remain to be elucidated. In this study, effects of IL-17 deficiency on collagen-induced arthritis (CIA) model were examined using IL-17-deficient mice (IL-17(-/-) mice). We found that CIA was markedly suppressed in IL-17(-/-) mice. IL-17 was responsible for the priming of collagen-specific T cells and collagen-specific IgG2a production. Thus, these observations suggest that IL-17 plays a crucial role in the development of CIA by activating autoantigen-specific cellular and humoral immune responses.
authors.affiliation: Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Nakae
authors.forename: Aya
authors.initials: A
authors.lastname: Nambu
authors.forename: Katsuko
authors.initials: K
authors.lastname: Sudo
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Iwakura
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D001323:Autoantibodies / Q000378:metabolism; D002455:Cell Division / Q000235:genetics / Q000276:immunology; D002478:Cells, Cultured; D002645:Chickens; D024043:Collagen Type II / Q000037:antagonists & inhibitors / Q000276:immunology*; D015536:Down-Regulation / Q000235:genetics* / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D007074:Immunoglobulin G / Q000378:metabolism; D015994:Incidence; D020381:Interleukin-17 / Q000172:deficiency* / Q000235:genetics* / Q000502:physiology; D008213:Lymphocyte Activation / Q000235:genetics / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
chemical_list: D001323:Autoantibodies; D024043:Collagen Type II; D018984:Epitopes, T-Lymphocyte; D007074:Immunoglobulin G; D020381:Interleukin-17