Patients with essential hypertension present higher levels of sE-selectin and sVCAM-1 than normotensive volunteers.
In essential hypertension (EH) patients, blood pressure can modify serum concentrations of some soluble forms of cell adhesion molecules (CAM), e.g., soluble E-selectin (sE-selectin) and soluble vascular cell adhesion molecule-1 (sVCAM-1). The objective of this study was to compare the serum levels of these CAMs in compensated (CH) and non-compensated (NCH) EH patients. Our findings show that sE-selectin and sVCAM-1 levels are higher in EH patients than normotensive subjects (sVCAM-1: 796+/-52 vs. 605+/-24 ng/mL, p<0.0001, and sE-selectin: 71+/-21 vs. 48+/-14 ng/mL, p<0.0001). Serum concentrations of both CAMs was higher in NCH patients than CH patients. High arterial blood pressure (ABP) may therefore increase the production of cell adhesion molecules, probably through endothelial activation.
Palomo
Iván
I
Department of Clinical Biochemistry and Immunohematology, School of Health Sciences, University of Talca, Talca, Chile. ipalomo@utalca.cl
Marín
Patricio
P
Alarcón
Marcelo
M
Gubelin
Gilda
G
Viñambre
Ximena
X
Mora
Eduardo
E
Icaza
Gloria
G
D001794:Blood Pressure; D016022:Case-Control Studies; D019040:E-Selectin / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1