Cytotoxic effects of sesquiterpene lactones from the flowers of Hemisteptia lyrata B.
Four guaia-12,6-olide type sesquiterpene lactones, aguerin B (1), 8alpha-acetoxyzaluzanin C (2), cynaropicrin (3), and deacylcynaropicrin (4), were isolated from the flowers of Hemisteptia lyrata Bunge. It is the first report on the isolation of compounds 1-4 from Hemisteptia species. All the isolates (1-4) were examined for their cytotoxic activity against SK-OV-3, LOX-IMVI, A549, MCF-7, PC-3, and HCT-15 human cancer cell lines.
Ha
Tae Joung
TJ
Institute of Agriculture and Life Science, Gyeongsang National University, Chinju 660-701, Korea.
Jang
Dae Sik
DS
Lee
Jong Rok
JR
Lee
Kyung Dong
KD
Lee
Jun
J
Hwang
Seon Woo
SW
Jung
Hwa Jin
HJ
Nam
Sang Hae
SH
Park
Ki Hun
KH
Yang
Min Suk
MS
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D019659:Asteraceae; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D035264:Flowers / Q000633:toxicity*; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*
D000970:Antineoplastic Agents; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes