Direct determination of triamterene by potentiometry using a coated wire selective electrode.
A coated wire triamterene-selective electrode based on the incorporation of a triamterene-tetraphenylborate ion-pair in a poly(vinylchloride) coating membrane was constructed. The influence of membrane composition, temperature, pH of the test solution, and foreign ions on the electrode performance were investigated. The electrode showed a Nernstian response over a triamterene concentration range from 1.0 x 10(-6) to 3.5 x 10(-2) M, at 25 degrees C, and was found to be very selective, precise, and usable within the pH range 4.5-7.5. The standard electrode potentials, E degrees, were determined at 15, 20, 25, 30, 35, 40 and 45 degrees C and used to calculate the isothermal temperature coefficient (dE degrees /dt) of the electrode. Temperatures higher than 45 degrees C seriously affected the electrode performance. The electrode was successfully applied to the potentiometric determination of triamterene hydrochloride both in pure solutions and in pharmaceutical preparations.
Arvand
M
M
Department of Chemistry, School of Sciences, Tarbiat Modarres University, P.O. Box 14115-111, Tehran, Iran.
Mousavi
M F
MF
Zanjanchi
M A
MA
Shamsipur
M
M
D017736:Ion-Selective Electrodes; D011199:Potentiometry / Q000379:methods; D014223:Triamterene / Q000032:analysis* / Q000737:chemistry* / Q000493:pharmacokinetics
D014223:Triamterene