title: Early results of a single-blinded, randomized, controlled, Internet-based multicenter trial comparing Prolene and Vypro II mesh in Lichtenstein hernioplasty.
abstract: BACKGROUND
  The standard polypropylene mesh used in Lichtenstein's operation induces a strong foreign-tissue reaction with potentially harmful effects. A mesh with less polypropylene could possibly be beneficial.
  
  
  METHODS
  Six hundred men with inguinal hernias were randomized to Lichtenstein's operation with Prolene or Vypro II in a single-blinded multicenter trial. The randomization was performed by a computer algorithm in a database through the Internet. All data were entered and directly validated in the database through the Internet.
  
  
  RESULTS
  The meshes had comparable results in return to work, return to daily activities, complications, postoperative pain, and quality of life during the first 8 weeks of rehabilitation.
  
  
  CONCLUSIONS
  Lichtenstein's operation with either Prolene or Vypro II is safe and well tolerated with an acceptable postoperative rehabilitation time and a high quality of life 2 months after surgery. The study was facilitated by the use of a database through the Internet.
authors.affiliation: Center For Surgical Sciences, K53 Karolinska Institutet at Huddinge University Hospital, 141 86, Stockholm, Sweden. sven.bringman@cfss.ki.se
authors.forename: Sven
authors.initials: S
authors.lastname: Bringman
authors.forename: Timo-Jaakko
authors.initials: TJ
authors.lastname: Heikkinen
authors.forename: Staffan
authors.initials: S
authors.lastname: Wollert
authors.forename: Johanna
authors.initials: J
authors.lastname: Osterberg
authors.forename: Sam
authors.initials: S
authors.lastname: Smedberg
authors.forename: Håkan
authors.initials: H
authors.lastname: Granlund
authors.forename: Stig
authors.initials: S
authors.lastname: Ramel
authors.forename: Göran
authors.initials: G
authors.lastname: Felländer
authors.forename: Bo
authors.initials: B
authors.lastname: Anderberg
mesh_terms: D000328:Adult; D000368:Aged; D006552:Hernia, Inguinal / Q000601:surgery*; D006801:Humans; D020407:Internet; D008297:Male; D008875:Middle Aged; D011098:Polyglactin 910; D011126:Polypropylenes; D011183:Postoperative Complications; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D016037:Single-Blind Method; D013526:Surgical Mesh
chemical_list: D011126:Polypropylenes; D011098:Polyglactin 910