title: Neuropsychological outcome after fractionated stereotactic radiotherapy (FSRT) for base of skull meningiomas: a prospective 1-year follow-up.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the cognitive outcome after fractionated stereotactic radiotherapy (FSRT) in patients with base of skull meningiomas.
  
  
  METHODS
  A total of 40 patients with base of skull meningiomas were neuropsychologically evaluated before, after the first fraction (1.8 Gy), at the end of FSRT (n=37), 6 weeks (n=24), 6 (n=18) and 12 months (n=14) after FSRT. A comprehensive test battery including assessment of general intelligence, attention and memory functions was used. Alternate forms were used and current mood state was controlled.
  
  
  RESULTS
  After the first fraction a transient decline in memory function and simultaneous improvements in attention functions were observed. No cognitive deteriorations were seen during further follow-up, but increases in attention and memory functions were observed. Mood state improved after the first fraction, at the end of radiotherapy and 6 weeks after radiotherapy.
  
  
  CONCLUSIONS
  The present data support the conclusion that the probability for the development of permanent cognitive dysfunctions appears to be very low after FSRT. The transient memory impairments on day 1 are interpreted as most likely related to an increase of a preexisting peritumoral edema, whereas the significant acute improvements in attention functions are interpreted as practice effects. An analysis of localization specific effects of radiation failed to show clear hemisphere specific cognitive changes.
authors.affiliation: Department of Neurology, University of Heidelberg, Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Steinvorth
authors.forename: Grit
authors.initials: G
authors.lastname: Welzel
authors.forename: Martin
authors.initials: M
authors.lastname: Fuss
authors.forename: Jürgen
authors.initials: J
authors.lastname: Debus
authors.forename: Susanne
authors.initials: S
authors.lastname: Wildermuth
authors.forename: Michael
authors.initials: M
authors.lastname: Wannenmacher
authors.forename: Frederik
authors.initials: F
authors.lastname: Wenz
mesh_terms: D000328:Adult; D003071:Cognition / Q000528:radiation effects*; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D008297:Male; D008579:Meningioma / Q000532:radiotherapy*; D008875:Middle Aged; D009483:Neuropsychological Tests; D011446:Prospective Studies; D019292:Skull Base Neoplasms / Q000532:radiotherapy*; D013238:Stereotaxic Techniques; D016896:Treatment Outcome