Duplicate, decouple, disperse: the evolutionary transience of human centromeric regions.
Human centromeric regions are enriched for segmental duplications, which elsewhere in the genome precipitate both genetic disease and gene formation. Molecular cytogenetic analyses of primate chromosomes have established that centromeres frequently move without altering the surrounding gene order. Recently, the positions of two ancestral centromeres have been mapped to regions of the human genome that are both rich in segmental duplications and are associated with duplication-based clinical phenotypes. This suggests a model for the evolution of euchromatic segmental duplication families involving the localised elevation of recombination rates within the duplication-rich heterochromatin of recently inactivated centromeres, and raises the possibility that the distribution of duplication/deletion syndromes within our genome has been heavily influenced by such events. The relaxation of the heterochromatin environment that must accompany centromere inactivation would also increase the transcriptional activity within previously pericentromeric DNA, increasing the likelihood of chimaeric gene creation through pericentromeric-directed duplication events.
Jackson
Michael
M
The Institute Of Human Genetics, The International Centre For Life, University Of Newcastle Upon Tyne, Central Parkway, Newcastle Upon Tyne NE1 3BZ, UK. m.s.jackson@ncl.ac.uk
D002503:Centromere / Q000235:genetics*; D002678:Chimera; D019143:Evolution, Molecular; D017353:Gene Deletion; D020440:Gene Duplication; D006570:Heterochromatin / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D010641:Phenotype; D011995:Recombination, Genetic
D006570:Heterochromatin