Motor effects of amphetamine in rats pretreated with either dizocilpine or phencyclidine.
The aim of the present study was to examine motor effects of amphetamine (AMPH) in rats pretreated with either dizocilpine (MK-801) or phencyclidine (PCP), and to estimate possible differences in these effects. Our results showed that AMPH increases the duration of motor effects of PCP, while it does not change motor effects of MK-801. These findings may reflect different mechanisms of action of MK-801 and PCP, as well as selective influence of AMPH on metabolism of these drugs.
Pesić
Vesna
V
Laboratory of Electrophysiology and Behavior, Department of Neurobiology and Immunology, Institute for Biological Research, 29 Novembra 142, 11060 Belgrade, Yugoslavia. vesnav@ibiss.bg.ac.yu
Janać
Branka
B
Milanović
Desanka
D
Tomić
Mirko
M
Veskov
Rosica
R
Rakić
Ljubisav
L
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004347:Drug Interactions; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009068:Movement / Q000187:drug effects; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D000697:Central Nervous System Stimulants; D018691:Excitatory Amino Acid Antagonists; D016291:Dizocilpine Maleate; D000661:Amphetamine; D010622:Phencyclidine