Immunohistochemical aid at risk stratification of melanocytic neoplasms.
There is increasing awareness of the population about the risk of cutaneous melanoma. In recent years, some improvement was gained in the early recognition of clinical warning signs using dermoscopy. As a result, the number of puzzling cases exhibiting limited classical clues for malignancy are submitted to the dermatopathologist. Thus, the risk of microscopic uncertainty or misdiagnosis may be increasing. The aim of the study was to assess retrospectively the contribution of immunohistochemistry in establishing the histological diagnosis of 520 melanocytic neoplasms. According to the disease evolution and the histological presentation, 6 profiles of phenotypical expressions were distinguished.
Quatresooz
Pascale
P
Department of Dermatopathology, University Hospital Sart Tilman, B-4000 Liège, Belgium.
Arrese
Jorge E
JE
Pierard-Franchimont
Claudine
C
Pierard
Gerald E
GE
D000911:Antibodies, Monoclonal / Q000276:immunology; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000276:immunology; D026122:Factor XIIIa / Q000032:analysis; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D058965:MART-1 Antigen; D008545:Melanoma / Q000175:diagnosis* / Q000378:metabolism; D058950:Melanoma-Specific Antigens; D014442:Monophenol Monooxygenase / Q000032:analysis; D054778:NM23 Nucleoside Diphosphate Kinases; D009363:Neoplasm Proteins / Q000032:analysis; D009701:Nucleoside-Diphosphate Kinase; D037121:Plant Lectins / Q000032:analysis; D011379:Prognosis; D011506:Proteins / Q000032:analysis; D012189:Retrospective Studies; D009418:S100 Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D006023:Glycoproteins; D019394:Ki-67 Antigen; D058965:MART-1 Antigen; C094218:MEL-5 protein, human; C548667:MLANA protein, human; D058950:Melanoma-Specific Antigens; D054778:NM23 Nucleoside Diphosphate Kinases; D009363:Neoplasm Proteins; D037121:Plant Lectins; D011506:Proteins; D009418:S100 Proteins; C036850:Ulex europaeus lectins; D014442:Monophenol Monooxygenase; D026122:Factor XIIIa; D009701:Nucleoside-Diphosphate Kinase