title: [Quantitative characteristics of the frequency of chromosomal aberrations in a group of residents of a large western Siberian industrial region].
abstract: The results of a 15-year study of chromosome aberration frequency in cultured peripheral blood lymphocytes from subjects living in the Kuzbass industrial region are presented. The database for the analysis of the main parameters of chromosome aberrations contains data on 925 subjects, with the total number of cells examined being 92,900. It has been found that the total frequency of aberrant metaphases in the database is 3.73 +/- 0.1%, whereas this frequency for the sample of subjects from industrial areas of this region (the basic control group) is significantly lower (2.86 +/- 0.26%). It has been demonstrated that the sex and age of the subjects do not affect substantially the frequency of any type of chromosome aberrations. Tobacco smoking is associated with a slight increase in chromosome damage frequency; however, the difference between smokers and nonsmokers is insignificant even among subjects exposed to occupational hazards. The possible causes that have determined the increased basic and background chromosome aberration frequencies in the population of the Kemerovo oblast compared to these parameters for the European part of Russia and the CIS are discussed.
authors.affiliation: Department of Human and Animal Physiology, Kemerovo State University, Kemerovo, 650043 Russia. druzhinin_vladim@mail.ru
authors.forename: V G
authors.initials: VG
authors.lastname: Druzhinin
mesh_terms: D002869:Chromosome Aberrations; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D007221:Industry; D008297:Male; D012800:Siberia; D012907:Smoking / Q000235:genetics