Nonarteritic anterior ischemic optic neuropathy and surgery of the anterior segment: temporal relationship analysis.
OBJECTIVE
This study analyzes the temporal relationship between intraocular lens surgery and nonarteritic anterior ischemic optic neuropathy (NAION).


METHODS
Retrospective cohort study.


METHODS
Eighteen cases of NAION in 17 subjects occurring within 1 year after lens-related surgery were identified with a retrospective review of patients diagnosed with NAION. The temporal relationship between NAION onset and surgery was evaluated by using an exact chi-square test of goodness of fit to compare the observed with a uniform distribution, which would be expected if intraocular surgery were not causal.


RESULTS
All 18 cases occurred within 6 months of surgery (mean interval, 35 days; range, 1-130 days), which is significantly different from a uniform distribution (P <.001).


CONCLUSIONS
Our data indicate that intraocular lens surgery is associated with the occurrence of NAION.
McCulley
Timothy J
TJ
Department of Ophthalmology, University of California at Irvine, College of Medicine, Irvine, California 92697-4375, USA. tmcculle@uci.edu
Lam
Byron L
BL
Feuer
William J
WJ
D000368:Aged; D000369:Aged, 80 and over; D000869:Anterior Eye Segment / Q000601:surgery*; D002387:Cataract Extraction / Q000009:adverse effects*; D005260:Female; D013700:Giant Cell Arteritis / Q000209:etiology; D006801:Humans; D019654:Lens Implantation, Intraocular / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D018917:Optic Neuropathy, Ischemic / Q000175:diagnosis / Q000209:etiology*; D011183:Postoperative Complications; D012189:Retrospective Studies; D013997:Time Factors