[Effect of iron on peroxidation and non-enzymatic glycation in diabetic rats].
SD rats were peritoneally injected with streptozotocin to establish diabetes mellitus animal model. The changes of nonenzymatic glycation and peroxidation in rats supplemented with low iron high iron during five weeks were investigated. It was found that MDA in serum or renal cortex but not glycated hemoglobin, glycated LDL, renal cortical AGEs increased significantly after supplementation of high iron in diabetic rats. There was no change in serum MDA, renal cortical MDA, glycated hemoglobin, glycated LDL and AGEs after supplementation of low iron in diabetic rats. The results suggested that peroxidation could be enhanced obviously by supplementation of high iron so that chronic complications could be promoted by high dose iron in diabetic rats.
Qian
Pingping
P
Department of Nutrition, No. 411 Hospital of PLA, Shanghai 200081, China.
Guo
Junsheng
J
Liu
Changyun
C
Niu
Yan
Y
Cheng
Shengqiu
S
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D007501:Iron / Q000008:administration & dosage / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D017127:Glycation End Products, Advanced; D008315:Malondialdehyde; D007501:Iron