[Application of chemiluminescent analysis for comparative assessment of antioxidant activity of some pharmacological compounds].
A comparative analysis of the antioxidant activity of a series of pharmacological compounds was performed in vitro using Fe2+ induced chemiluminescence of lipoproteins. With respect to the protective action against lipoprotein oxidation, the compounds studied can be arranged in the following order: trolox > carnosine > emoxypine > L-carnitine = mildronate. The results show good prospects for using the proposed chemiluminescent technique for evaluating the antioxidant activity of pharmaceuticals.
Fedorova
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TN
Department of Neurochemistry, Institute of Neurology, Russian Academy of Medical Sciences, Volokolamskoc sh. 80, Moscow, 123367 Russia.
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D005296:Ferrous Compounds / Q000737:chemistry; D006801:Humans; D066298:In Vitro Techniques; D008074:Lipoproteins / Q000097:blood / Q000737:chemistry*; D008163:Luminescent Measurements; D016877:Oxidants / Q000737:chemistry; D010084:Oxidation-Reduction
D000975:Antioxidants; D005296:Ferrous Compounds; D008074:Lipoproteins; D016877:Oxidants