title: Novel biologically active natural and unnatural products.
abstract: Natural products have been used as medicinal agents for many years. In addition, these compounds have served as the starting points for semisynthetic analogs with improved properties. This review highlights work on several classes of natural products and their derivatives, including both well established and emerging structural classes that are in, or nearing, clinical use for a variety of important indications.
authors.affiliation: Kosan Biosciences, Inc., 3832 Baycenter Place, Hayward, CA 94545, USA. myles@kosan.com
authors.forename: David C
authors.initials: DC
authors.lastname: Myles
mesh_terms: D000473:Alkanes / Q000737:chemistry / Q000302:isolation & purification; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification; D002219:Carbamates / Q000737:chemistry / Q000302:isolation & purification; D034261:Epothilones / Q000737:chemistry* / Q000302:isolation & purification; D004917:Erythromycin / Q000737:chemistry* / Q000302:isolation & purification; D005663:Furans; D006094:Gram-Positive Bacteria / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification; D008055:Lipids; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification; D008956:Models, Chemical; D011753:Pyrones; D013329:Structure-Activity Relationship; D043823:Taxoids / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D000473:Alkanes; D000935:Antifungal Agents; D002219:Carbamates; D034261:Epothilones; D005663:Furans; D007783:Lactones; D008055:Lipids; D018942:Macrolides; D011753:Pyrones; D043823:Taxoids; C470814:dictyostatin; C058744:tautomycetin; D004917:Erythromycin; C071229:discodermolide