Cell migration: integrating signals from front to back.
Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mental retardation, atherosclerosis, and arthritis. The migrating cell is highly polarized with complex regulatory pathways that spatially and temporally integrate its component processes. This review describes the mechanisms underlying the major steps of migration and the signaling pathways that regulate them, and outlines recent advances investigating the nature of polarity in migrating cells and the pathways that establish it.
Ridley
Anne J
AJ
Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK.
Schwartz
Martin A
MA
Burridge
Keith
K
Firtel
Richard A
RA
Ginsberg
Mark H
MH
Borisy
Gary
G
Parsons
J Thomas
JT
Horwitz
Alan Rick
AR
D008841:Actin Cytoskeleton / Q000502:physiology; D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D016764:Cell Polarity; D006801:Humans; D016023:Integrins / Q000502:physiology; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism; D011554:Pseudopodia / Q000502:physiology; D015398:Signal Transduction
D016023:Integrins; D011506:Proteins