title: Intracerebroventricular injection of muscimol, baclofen or nipecotic acid stimulates food intake in layer-type, but not meat-type, chicks.
abstract: This study was designed to compare the effects of muscimol (GABA(A) agonist), baclofen (GABA(B) agonist) and nipecotic acid (GABA uptake inhibitor) on food intake in two chicken strains (meat-type and layer-type chicks). The intracerebroventricular (ICV) injection of all GABA agents induced hyperphagia in layer-type chicks. However, in broiler chicks, there were similar tendencies with muscimol and nipecotic acid but not significantly different. Conversely, ICV injection of baclofen depressed feeding of broiler chicks. These results suggest that there are some differences in central GABAergic systems between these strains of chicks, but GABAergic systems have an important role in the regulation of food intake in neonatal chicks.
authors.affiliation: Laboratory of Animal Science, Department of Agrobiological Science, Faculty of Agriculture, Ehime University, 3-5-7 Tarumi, Matsuyama 790-8566, Japan. bungo@agr.ehime-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Bungo
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Izumi
authors.forename: Kazuya
authors.initials: K
authors.lastname: Kawamura
authors.forename: Tomo
authors.initials: T
authors.lastname: Takagi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ueda
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Furuse
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001418:Baclofen / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002645:Chickens / Q000145:classification; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D018755:GABA Agonists / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009118:Muscimol / Q000494:pharmacology*; D009557:Nipecotic Acids / Q000494:pharmacology*; D013045:Species Specificity
chemical_list: D018755:GABA Agonists; D009557:Nipecotic Acids; C030278:nipecotic acid; D009118:Muscimol; D001418:Baclofen