title: Induction of localized differences in rat uterine radial artery behavior and structure during gestation.
abstract: OBJECTIVE
  The objectives of this study were to investigate differences in diameter and vasoconstriction of premyometrial versus uteroplacental radial arteries and to evaluate the contribution of nitric oxide (NO) to myogenic tone as a function of vessel location.
  
  
  METHODS
  Radial arteries supplying either the myometrium or placenta were dissected from the uterus of pregnant rats. Constrictor responses to pressure elevation were studied before and after inhibition of endothelial NO synthase (eNOS).
  
  
  RESULTS
  Passive lumen diameters of premyometrial and proximal uteroplacental arteries were comparable and significantly smaller than those of distal uteroplacental vessels. High potassium- and pressure-induced responses were also similar in premyometrial and proximal but were virtually absent in distal uteroplacental segments. L-NNA enhanced pressure-induced tone, but was without effect in distal uteroplacental segments.
  
  
  CONCLUSIONS
  Gestational remodeling alters arterial structure and reactivity in a highly localized manner. During pregnancy, enhanced basal production of NO may be an important local mechanism for uterine blood flow regulation.
authors.affiliation: Department of Obstetrics and Gynecology, Given C-220, College of Medicine, University of Vermont, Burlington, VT 05405, USA. Natalia.Gokina@uvm.edu
authors.forename: Natalia I
authors.initials: NI
authors.lastname: Gokina
authors.forename: Maurizio
authors.initials: M
authors.lastname: Mandalà
authors.forename: George
authors.initials: G
authors.lastname: Osol
mesh_terms: D000818:Animals; D001158:Arteries / Q000033:anatomy & histology / Q000187:drug effects / Q000201:enzymology / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000502:physiology; D052250:Nitric Oxide Synthase Type III; D019335:Nitroarginine / Q000494:pharmacology; D010920:Placenta / Q000098:blood supply; D011188:Potassium / Q000008:administration & dosage; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D011312:Pressure; D051381:Rats; D017207:Rats, Sprague-Dawley; D014599:Uterus / Q000098:blood supply*; D014661:Vasoconstriction; D014666:Vasomotor System / Q000187:drug effects
chemical_list: D004791:Enzyme Inhibitors; D019335:Nitroarginine; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat; D011188:Potassium