TRP channels as cellular sensors.
TRP channels are the vanguard of our sensory systems, responding to temperature, touch, pain, osmolarity, pheromones, taste and other stimuli. But their role is much broader than classical sensory transduction. They are an ancient sensory apparatus for the cell, not just the multicellular organism, and they have been adapted to respond to all manner of stimuli, from both within and outside the cell.
Clapham
David E
DE
Howard Hughes Medical Institute, Pediatric Cardiology, Children's Hospital of Boston, Department of Neurobiology, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA. dclapham@enders.tch.harvard.edu
D000818:Animals; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002477:Cells / Q000378:metabolism*; D006801:Humans; D015640:Ion Channel Gating; D008954:Models, Biological; D015398:Signal Transduction; D050052:TRPC Cation Channels
D015220:Calcium Channels; D050052:TRPC Cation Channels; D002118:Calcium