A high frequency of BRCA2 gene mutations in Polish families with ovarian and stomach cancer.
Germ-line mutations in the BRCA2 gene are associated with a wide range of cancer types, including the breast, ovary, pancreas, prostate and melanoma. In this study, we evaluated the importance of a family history of stomach cancer in predicting the presence of a BRCA2 mutation in Polish patients with ovarian cancer. A BRCA2 mutation was found in eight of 34 women with ovarian cancer and a family history of stomach cancer versus three of 75 women with ovarian cancer and a family history of ovarian cancer, but not of stomach cancer (odds ratio=7.4; 95% CI 1.8-30; P=0.004). The results of this study suggest that, in the Polish population, the constellation of ovarian and stomach cancer predicts the presence of a germ-line BRCA2 mutation and confirms that stomach cancer is part of the spectrum of BRCA2 mutations. It is expected that the penetrance of BRCA2 mutations for stomach cancer will vary from country to country, reflecting local environmental and lifestyle factors.
Jakubowska
Anna
A
Department of Genetics and Pathology, Pomeranian Academy of Medicine, Szczecin, Poland. aniaj@sci.pam.szczecin.pl
Scott
Rodney
R
Menkiszak
Janusz
J
Gronwald
Jacek
J
Byrski
Tomasz
T
Huzarski
Tomasz
T
Górski
Bohdan
B
Cybulski
Cezary
C
Debniak
Tadeusz
T
Kowalska
Elzbieta
E
Starzyńska
Teresa
T
Ławniczak
Małgorzata
M
Narod
Steven
S
Lubinski
Jan
J
D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D024522:Genes, BRCA2; D018095:Germ-Line Mutation; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*; D011044:Poland