title: B-ring unsaturated estrogens: biological evaluation of 17alpha-Dihydroequilein and novel B-Nor-6-thiaequilenins as tissue selective estrogens.
abstract: The pharmacology and SAR of representative equine estogens is described. 17alpha-Dihydroequilenin was found to prevent bone loss after 5 weeks of oral administration to ovariectomized rats. The stereochemical significance of the D-ring and the C/D ring juncture was investigated with a series of benzothiophene-based equilenin analogues.
authors.affiliation: Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.
authors.forename: Charles W
authors.initials: CW
authors.lastname: Lugar
authors.forename: David
authors.initials: D
authors.lastname: Magee
authors.forename: Mary D
authors.initials: MD
authors.lastname: Adrian
authors.forename: Pamela
authors.initials: P
authors.lastname: Shetler
authors.forename: Henry U
authors.initials: HU
authors.lastname: Bryant
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Dodge
mesh_terms: D000818:Animals; D004857:Equilin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045166:Estradiol Congeners / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D008958:Models, Molecular; D008968:Molecular Conformation; D009929:Organ Size / Q000187:drug effects; D010052:Ovariectomy; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014599:Uterus / Q000033:anatomy & histology / Q000187:drug effects
chemical_list: D045166:Estradiol Congeners; D004857:Equilin; C014482:dihydroequilin