title: Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: meeting summary.
abstract: Childhood osteogenic sarcoma (OS) is a rare bone cancer occurring primarily in adolescents. The North American pediatric cooperative groups have performed a series of clinical treatment trials in this disease over the past several decades, and biology studies of tumor tissue have been an important study component. A meeting was held in Bethesda, Maryland on November 29-30, 2001, sponsored by the NIH Office of Rare Diseases, the Children's Oncology Group, and the National Cancer Institute-Cancer Therapy Evaluation Program with the general objectives: (a) to review the current state of knowledge regarding OS biology; (b) to identify, prioritize, and support the development of biology studies of potential clinical relevance in OS; and (c) to discuss the available tissue resources and the appropriate methods for analysis of OS samples for the conduct of biology studies. This report summarizes the information presented and discussed by the meeting participants.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
authors.forename: Richard
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authors.lastname: Gorlick
authors.forename: Peter
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authors.lastname: Anderson
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authors.lastname: Bridge
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authors.lastname: Cheung
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authors.lastname: Hansen
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authors.lastname: Hock
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authors.lastname: Houghton
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authors.lastname: Houghton
authors.forename: Andrew
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authors.lastname: Huvos
authors.forename: Chand
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authors.lastname: Khanna
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authors.lastname: Kieran
authors.forename: Eugenie
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authors.lastname: Kleinerman
authors.forename: Marc
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authors.lastname: Ladanyi
authors.forename: Ching
authors.initials: C
authors.lastname: Lau
authors.forename: David
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authors.lastname: Malkin
authors.forename: Neyssa
authors.initials: N
authors.lastname: Marina
authors.forename: Paul
authors.initials: P
authors.lastname: Meltzer
authors.forename: Paul
authors.initials: P
authors.lastname: Meyers
authors.forename: Deborah
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authors.lastname: Schofield
authors.forename: Cindy
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authors.lastname: Schwartz
authors.forename: Malcolm A
authors.initials: MA
authors.lastname: Smith
authors.forename: Jeffrey
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authors.lastname: Toretsky
authors.forename: Maria
authors.initials: M
authors.lastname: Tsokos
authors.forename: Leonard
authors.initials: L
authors.lastname: Wexler
authors.forename: Jon
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authors.lastname: Wigginton
authors.forename: Stephen
authors.initials: S
authors.lastname: Withrow
authors.forename: Mason
authors.initials: M
authors.lastname: Schoenfeldt
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authors.lastname: Anderson
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000235:genetics / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D002648:Child; D006801:Humans; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D012516:Osteosarcoma / Q000235:genetics / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy
chemical_list: D020533:Angiogenesis Inhibitors