title: Androgen-dependent atypical fibromas spontaneously arising in the skin of Djungarian hamsters (Phodopus sungorus).
abstract: Spontaneous atypical fibromas that arose in the thoracoabdominal skin of one aged female and 31 aged male Djungarian hamsters (Phodopus sungorus) were examined histologically, immunohistochemically, and ultrastructurally. The normal skin from both sexes obtained at various intervals until the age of 12 months was examined, as were the tumors. These tumors were composed of ganglion cell-like (GL) cells that had one or two ovoid nuclei, basophilic foamy cytoplasm, and various amount of collagen fibers between the cells. The tumor cells had positive reaction to vimentin and androgen receptor (AR); the stromal collagen fibers reacted positively with the antibody against collagen type I or III. Ultrastructurally, the tumor cells had abundant rough endoplasmic reticulum in the cytoplasm. On the other hand, small nests of the cells mimicking tumor GL cells were present in the dermal layer to the panniculus of the normal thoracoabdominal skin of adult males, but were seldom found in adult females. The morphologic and immunohistochemical features of these tumor GL cells were basically similar to those of normal skin GL cells, although the former had a certain degree of atypia. These results suggest that atypical skin fibroma in the Djungarian hamster is an androgen-dependent tumor and originates from skin GL cells.
authors.affiliation: Department of Veterinary Pathology, Nippon Veterinary and Animal Science University, 1-7-1 Kyonan-cho, Musashinoshi, Tokyo 180-8602, Japan.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Baba
authors.forename: Kimimasa
authors.initials: K
authors.lastname: Takahashi
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000728:Androgens / Q000378:metabolism*; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D024042:Collagen Type I / Q000378:metabolism; D024061:Collagen Type III / Q000378:metabolism; D006224:Cricetinae; D018870:Endoplasmic Reticulum, Rough / Q000648:ultrastructure; D005260:Female; D005350:Fibroma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D017111:Phodopus; D011944:Receptors, Androgen / Q000378:metabolism; D012376:Rodent Diseases / Q000378:metabolism / Q000473:pathology*; D012867:Skin / Q000378:metabolism* / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D014746:Vimentin / Q000378:metabolism
chemical_list: D000728:Androgens; D014408:Biomarkers, Tumor; D024042:Collagen Type I; D024061:Collagen Type III; D011944:Receptors, Androgen; D014746:Vimentin