Cronkhite-Canada syndrome with adenomatous and carcinomatous transformation of colonic polyp.
We describe a 70-year-old woman who presented with watery diarrhea and was found to have gastric and colonic polyposis, cutaneous hyperpigmentation, alopecia and onychodystrophy (Cronkhite-Canada syndrome). Histology of a polyp from the stomach showed features of juvenile or retention type (hamartomatous) polyp. One colonic polyp revealed features of tubular adenoma, with moderate dysplasia. Another large pedunculated colonic polyp showed a tubulovillous adenoma with a focus of well-differentiated adenocarcinoma confined to the submucosa of the stalk. Adenomatous and carcinomatous epithelial changes can occur in Cronkhite-Canada syndrome.
Jain
Anil
A
Department of Medicine, Maulana Azad Medical College, New Delhi 110 002.
Nanda
Soni
S
Chakraborty
P
P
Kundra
A
A
Anuradha
S
S
Reddy
B S N
BS
Kar
P
P
D000230:Adenocarcinoma / Q000473:pathology*; D000236:Adenoma / Q000473:pathology*; D018253:Adenoma, Villous / Q000473:pathology*; D000368:Aged; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology*; D003111:Colonic Polyps / Q000473:pathology*; D005260:Female; D006801:Humans; D044483:Intestinal Polyposis / Q000473:pathology*