title: Two-year follow-up of subthalamic deep brain stimulation in Parkinson's disease.
abstract: We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN-DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow-up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow-up, STN-DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN-DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN-DBS beyond the first year after surgical procedure. Complications of STN-DBS comprise a wide range of psychiatric adverse events which, however, were temporary.
authors.affiliation: Department of Neurology, Christian-Albrechts Universität Kiel, Kiel, Germany.
authors.forename: Jan
authors.initials: J
authors.lastname: Herzog
authors.forename: Jens
authors.initials: J
authors.lastname: Volkmann
authors.forename: Paul
authors.initials: P
authors.lastname: Krack
authors.forename: Florian
authors.initials: F
authors.lastname: Kopper
authors.forename: Monika
authors.initials: M
authors.lastname: Pötter
authors.forename: Delia
authors.initials: D
authors.lastname: Lorenz
authors.forename: Meike
authors.initials: M
authors.lastname: Steinbach
authors.forename: Stefan
authors.initials: S
authors.lastname: Klebe
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hamel
authors.forename: Bettina
authors.initials: B
authors.lastname: Schrader
authors.forename: Dieter
authors.initials: D
authors.lastname: Weinert
authors.forename: Dieter
authors.initials: D
authors.lastname: Müller
authors.forename: Hubertus M
authors.initials: HM
authors.lastname: Mehdorn
authors.forename: Günther
authors.initials: G
authors.lastname: Deuschl
mesh_terms: D004558:Electric Stimulation / Q000295:instrumentation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000175:diagnosis / Q000628:therapy*; D012720:Severity of Illness Index; D020531:Subthalamic Nucleus / Q000502:physiology*