title: Alcohol consumption and the risk of mucinous and nonmucinous epithelial ovarian cancer.
abstract: OBJECTIVE
  To examine alcohol consumption as a risk factor for epithelial ovarian cancer according to tumor histology.
  
  
  METHODS
  We examined total alcohol consumption and consumption of beer, wine, and spirits as risk factors for mucinous and nonmucinous tumors in a population-based, case-control study comparing 761 incident cases of epithelial ovarian cancer with 1352 community controls frequency-matched to cases by age and three-digit telephone exchange. Multivariable, unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for mucinous and nonmucinous tumors associated with alcohol consumption. Adjustments were made for age, parity, oral contraceptive use, education, tubal ligation, smoking, and family history of ovarian cancer.
  
  
  RESULTS
  Overall, no association between total alcohol consumption and ovarian cancer was found. However, current heavy alcohol consumption (24 g or more per day) was associated with mucinous (OR 1.93; 95% CI 1.02, 3.65) but not nonmucinous tumors (OR 0.88; 95% CI 0.57, 1.37). The association between heavy current consumption and mucinous tumors was strongest for spirits (OR 8.83; 95% CI 2.89, 27.01) and apparent for beer (OR 2.53; 95% CI 0.86, 7.42). For nonmucinous tumors, no such associations were found for either spirits (OR 1.53; 95% CI 0.58, 4.00) or beer (OR 0.92; 95% CI 0.39, 2.14).
  
  
  CONCLUSIONS
  Current heavy consumption of alcohol might be a risk factor for mucinous but not nonmucinous epithelial ovarian cancer. This supports the hypothesis of a distinct etiology for mucinous tumors.
authors.affiliation: Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. fm@cs.cmu.edu
authors.forename: Francesmary
authors.initials: F
authors.lastname: Modugno
authors.forename: Roberta B
authors.initials: RB
authors.lastname: Ness
authors.forename: Glenn O
authors.initials: GO
authors.lastname: Allen
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000453:epidemiology* / Q000209:etiology; D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors