[Effect of the bone cement on human fibroblast culture and possible ways of its correction by cytoprotector preparations].
The results of in vitro investigation are used to assess the effect of poly(methyl methacrylate) based bone cements (BCs) upon human fibroblast culture. The dose dependent cytotoxic effect of BCs (Polacris) was manifested by the development of oxidative stress and hypoxia (on the cell level) and by a decrease in the cell ability to multiplication. The drugs possessing antihypoxant (mafusol) and antioxidant (erysod) activity, introduced into the incubation medium in clinically adequate doses, significantly reduced the toxic effect of BCs. The maximum positive effect was observed upon a combined administration of both drugs.
Eropkina
E M
EM
Vreden Institute of Traumatology and Orthopedics, ul. Akademika Baikova 8, St. Petersburg, 195427 Russia.
Mamaeva
E G
EG
Eropkin
M Iu
MIu
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001843:Bone Cements / Q000737:chemistry / Q000633:toxicity*; D002478:Cells, Cultured; D019610:Cytoprotection / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D005561:Formates / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020366:Methylmethacrylate / Q000737:chemistry / Q000633:toxicity; D013482:Superoxide Dismutase / Q000737:chemistry / Q000494:pharmacology
D000975:Antioxidants; D001843:Bone Cements; D005561:Formates; C030544:formic acid; D020366:Methylmethacrylate; D013482:Superoxide Dismutase