title: Mutagenic activity as a parameter to assess ambient air quality for protection of the environment and human health.
abstract: Atmospheric pollution has significant effects on maintaining the integrity of ecosystems and on the population's quality of life. Epidemiological studies have clearly associated related health problems, especially respiratory diseases, with exposure to air pollution. Organic compounds adsorbed to the airborne particulate matter are mutagenic in the Salmonella/microsome assay, and a considerable number of them are known to be carcinogenic to rodents. Studies performed at four sites within the urban area of Porto Alegre, capital of the state of Rio Grande do Sul, identified higher mutagenic activity at the sites with heavier vehicle traffic in assays without and with metabolic activation. The responses varied at different seasons of the year, and the highest revertants per cubic meter (rev/m(3)) values were observed in spring for moderately polar compounds, and in summer for non-polar ones. A pilot study was also performed in the region under the influence of a industrial petrochemical area. Most of the sites studied within the industrial area, as compared to others sampled in the nearby environment, presented higher levels of mutagenic activity independent of total suspended particulates (TSP) concentration in the sample. In the urban and industrial regions, the observed mutagenic activities were strongly associated with the presence of polycyclic aromatic hydrocarbons (PAHs). The responses observed in the TA98NR and TA98/1,8-DNP(6) strains suggest the activity of nitrocompounds in both studies. The Salmonella/microsome assay is a sensitive method to define areas contaminated by these compounds, even in samples with TSP values that are consistent with the legal environmental quality standards.
authors.affiliation: Programa de Pesquisas Ambientais, Fundação Estadual de Proteção Ambiental Henrique Luis Roessler (FEPAM), Avenida Dr. Salvador França, 1707 CEP: 90690-000, Porto Alegre, RS, Brazil. vvargas@brturbo.com
authors.forename: Vera Maria Ferrão
authors.initials: VM
authors.lastname: Vargas
mesh_terms: D000388:Air / Q000592:standards*; D003247:Conservation of Natural Resources / Q000379:methods*; D006801:Humans; D009153:Mutagens / Q000633:toxicity*
chemical_list: D009153:Mutagens