title: [Change of circulating TNF-alpha in patients with advanced periodontitis before and after periodontal initial therapy].
abstract: OBJECTIVE
  To investigate the effect of periodontal initial therapy on circulating tumor necrosis factor-alpha (TNF-alpha) in patients with periodontitis.
  
  
  METHODS
  Patients with advanced periodontitis were selected. Sulcus bleeding index (SBI), probing depth (PD), and circulating TNF-alpha concentration were assessed respectively before and 4-6 weeks after periodontal initial therapy.
  
  
  RESULTS
  The level of circulating TNF-alpha in patients with periodontitis was significantly higher than that in healthy control subjects (P < 0.01). After periodontal initial therapy, SBI, PD and circulating TNF-alpha concentration were reduced significantly (P < 0.01) in patients with periodontitis.
  
  
  CONCLUSIONS
  Periodontitis may have profound effects on systemic health through the elevation of circulating TNF-alpha. Prevention and treatment of periodontitis should be important in maintaining systemic health.
authors.affiliation: Department of Periodontology, School of Stomatology, Qilu Hospital, Shandong University, Shandong 250012, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Pi-shan
authors.initials: PS
authors.lastname: Yang
authors.forename: Xiang-min
authors.initials: XM
authors.lastname: Qi
authors.forename: Jian-min
authors.initials: JM
authors.lastname: Ren
authors.forename: Shao-hua
authors.initials: SH
authors.lastname: Ge
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000097:blood* / Q000628:therapy; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D014409:Tumor Necrosis Factor-alpha