title: Increased lung uptake of technetium-99m hexamethylpropylene amine oxime in diffuse infiltrative lung disease.
abstract: BACKGROUND
  Diffuse infiltrative lung disease (ILD) is a heterogeneous group of disorders which predominantly affect the lung parenchyma and spare the airway.
  
  
  OBJECTIVE
  To assess pulmonary vascular endothelium damage in ILD, the lung uptake of technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO) was determined.
  
  
  METHODS
  In 20 ILD patients and 25 controls without ILD, the lung uptake of 99mTc-HMPAO was measured. Anterior lung imaging, including a large part of the liver, was made 10 min after intravenous injection of 20-25 mCi of 99mTc-HMPAO. Regions of interest covered the liver and lung to calculate the lung/liver uptake ratios. The 20 ILD patients included 10 patients with clinically manifest pulmonary disease (group 1) and 10 asymptomatic patients (group 2). All of the study subjects had normal pulmonary function test results.
  
  
  RESULTS
  The mean lung/liver uptake ratio in the 25 controls without ILD (0.36 +/- 0.10) was significantly lower than that in the 20 ILD patients (0.97 +/- 0.61). In addition, the mean lung/liver uptake ratio in the 10 ILD patients with clinically manifest pulmonary disease (1.45 +/- 0.51) was higher than that of the other 10 asymptomatic ILD patients (0.49 +/- 0.09).
  
  
  CONCLUSIONS
  Our results indicated that determining the lung/liver uptake ratio on 99mTc-HMPAO lung imaging should be an objective method to assess subclinical pulmonary damage in ILD patients.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, China Medical College Hospital, Taichung, Taiwan.
authors.forename: L-W
authors.initials: LW
authors.lastname: Hang
authors.forename: Y-C
authors.initials: YC
authors.lastname: Shiau
authors.forename: W-H
authors.initials: WH
authors.lastname: Hsu
authors.forename: J J-P
authors.initials: JJ
authors.lastname: Tsai
authors.forename: J-J
authors.initials: JJ
authors.lastname: Yeh
authors.forename: A
authors.initials: A
authors.lastname: Kao
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008168:Lung / Q000000981:diagnostic imaging*; D008171:Lung Diseases / Q000000981:diagnostic imaging*; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime