Cytokinesis: progress on all fronts.
Cell multiplication requires sequestration of the duplicated and segregated genome into two daughter cells. The mitotic spindle is critical for orchestrating sister chromatid separation and division plane positioning. During anaphase, spindle microtubules become bundled to form the central spindle, which is essential for completion of cytokinesis. Central spindle assembly is mediated by a microtubule-associated protein and a kinesin-RhoGAP complex, both of which are regulated by phosphorylation/dephosphorylation. The central spindle also plays a role in cleavage furrow positioning, which appears to involve activation of RhoA. New results have provided some initial clues as to how furrow positioning is achieved. Particularly notable is the discovery that a protein activated by RhoA, formin, has actin nucleation activity.
Glotzer
Michael
M
Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria. mglotzer@imp.univie.ac.jp
D000199:Actins / Q000378:metabolism; D000705:Anaphase; D000818:Animals; D017173:Caenorhabditis elegans; D002453:Cell Cycle; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism; D004330:Drosophila; D016547:Kinesins; D008870:Microtubules; D010766:Phosphorylation; D008941:Spindle Apparatus / Q000502:physiology; D020742:rhoA GTP-Binding Protein / Q000378:metabolism
D000199:Actins; D016547:Kinesins; D020742:rhoA GTP-Binding Protein