title: Severe neurotoxicity in tacrolimus-treated living kidney transplantation in two cases.
abstract: Two living kidney-transplant recipients under tacrolimus-based immunosuppressive therapy experienced severe neurotoxicity, with tonic-clonic seizures. In both cases the dosage reduction did not result in improvement of symptoms, which completely disappeared after modification of the immunosuppressive regimen from tacrolimus to cyclosporine. Severe neurotoxicity, with seizures or uncommon clinical features, such as serious myalgias, is not foreseeable. We recommend the conversion to cyclosporine-based immunosuppression in such cases.
authors.affiliation: Department of Surgery, Transplantation and Advanced Technologies, Organ Transplant Unit, University Hospital of Catania, Catania, Italy. pveroux@mbox.unict.it
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Veroux
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Veroux
authors.forename: Carmelo
authors.initials: C
authors.lastname: Puliatti
authors.forename: Mariachiara
authors.initials: M
authors.lastname: Valvo
authors.forename: Maurizio
authors.initials: M
authors.lastname: Macarone
authors.forename: Dario
authors.initials: D
authors.lastname: Cappello
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation; D019520:Living Donors; D008297:Male; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D012720:Severity of Illness Index; D016559:Tacrolimus / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus