[Effect of intravenous administration of monoantibody to P-selectin on the distribution of ACC-M adhesion in lung].
OBJECTIVE
To investigate the effect of intravenous administration of monoantibody to P-selectin (PS1) on the lung-metastasis characteristic of highly lung metastatic adenoid cystic carcinoma cell strain (ACC-M).


METHODS
3HTdR labeled ACC-M cells were injected intravenously through tail vein after using monoantibody to P-selectin. A mice of each group were killed at 2 h, 6 h and 18 h after infusion, respectively. The relative radioactivity (CPM) in the lung and liver was detected.


RESULTS
3H-activity per gram in lung of mAb group was lower than in control group. There was significant difference between the two groups (P < 0.001). There was no difference between the two groups of liver tissues (P > 0.005).


CONCLUSIONS
The results of this study suggested that the highly lung metastasis characteristic of ACC-M may be partially inhibited by the use of monoantibody to the P-selectin.
Wang
Xin-jun
XJ
Department of Oral and Maxillofacial Surgery, School of Stomatology, Shanghai Ninth People's Hospital, Shanghai Second Medical University, Shanghai 200011, China.
Chen
Wan-tao
WT
Yu
Yang
Y
Zhou
Xiao-jian
XJ
Xu
Qin
Q
Cai
Dian-cai
DC
D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology / Q000628:therapy*; D002448:Cell Adhesion; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary*; D051379:Mice; D008819:Mice, Nude; D019007:P-Selectin / Q000276:immunology / Q000502:physiology*
D000906:Antibodies; D019007:P-Selectin