title: Subthalamic somatosensory evoked potentials in Parkinson's disease.
abstract: Deep brain stimulation (DBS) of subthalamic nucleus (STN) is an effective treatment for advanced Parkinson's disease. It also provides an opportunity to record neural activity from the human basal ganglia. In this study, to investigate the involvement of the human STN in sensory functions, we recorded somatosensory evoked potentials (SEPs) elicited by contralateral median-nerve stimulation, from STN electrodes implanted for DBS in patients with Parkinson's disease. We suggest that the STN N18 component of SEPs in Parkinson's disease is a mainly local field potential elicited by muscle afferent input to the nucleus.
authors.affiliation: Dipartimento di Neuroscienze e Organi di Senso, IRCCS-Ospedale Maggiore Milano, Milano, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pesenti
authors.forename: Alberto
authors.initials: A
authors.lastname: Priori
authors.forename: Marco
authors.initials: M
authors.lastname: Locatelli
authors.forename: Marcello
authors.initials: M
authors.lastname: Egidi
authors.forename: Paolo
authors.initials: P
authors.lastname: Rampini
authors.forename: Filippo
authors.initials: F
authors.lastname: Tamma
authors.forename: Elena
authors.initials: E
authors.lastname: Caputo
authors.forename: Valentina
authors.initials: V
authors.lastname: Chiesa
authors.forename: Sergio
authors.initials: S
authors.lastname: Barbieri
mesh_terms: D000328:Adult; D000368:Aged; D004558:Electric Stimulation / Q000295:instrumentation; D004567:Electrodes, Implanted; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000294:innervation; D010300:Parkinson Disease / Q000503:physiopathology*; D020531:Subthalamic Nucleus / Q000503:physiopathology*