title: Doses to fetal and maternal organs from intravenous 59FeCl3 or 57CoCl2.
abstract: Doses from intravenous intakes of 59Fe or 57Co chloride during pregnancy were estimated. Near term fetal organ doses were derived via the MIRDOSE3 newborn phantom, with mean dose/cumulated activity (S) values rescaled for compatibility with near term fetus whole body S. A detailed in vivo biodistribution database provided indications of residence times in important maternal and fetal organs. 59Fe doses to the fetus whole body from early to late pregnancy were 7-11 mGy MBq(-1) (8.5-14.3 mSv MBq(-1)), similar to that to the mother. Doses to near term fetal spleen (59 mGy MBq(-1)), liver (36), and red marrow (9) were similar or higher than to the mother. 57Co doses to fetus whole body from early to late pregnancy were 0.7-3.3 mGy MBq(-1) (2.5-8.2 mSv MBq(-1)), similar or higher than to the mother. Doses to near term fetal small intestine (34 mGy MBq(-1)). liver (4.7) and red marrow (2.7) were similar or higher than to the mother.
authors.affiliation: Medical Physics, Division of Oncology, University of Bristol, UK.
authors.forename: M
authors.initials: M
authors.lastname: Saunders
authors.forename: A M
authors.initials: AM
authors.lastname: Palmer
authors.forename: R K
authors.initials: RK
authors.lastname: Millard
authors.forename: A W
authors.initials: AW
authors.lastname: Preece
mesh_terms: D001822:Body Burden; D003037:Cobalt Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003198:Computer Simulation; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D007504:Iron Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D009928:Organ Specificity; D011247:Pregnancy; D011264:Pregnancy Trimesters / Q000502:physiology; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D012062:Relative Biological Effectiveness; D018570:Risk Assessment / Q000379:methods*
chemical_list: D003037:Cobalt Radioisotopes; D007504:Iron Radioisotopes