title: [Expression of S100 in oral submucose fibrosis].
abstract: OBJECTIVE
  To study the expression of S100 in oral submucose fibrosis(OSF).
  
  
  METHODS
  Immunohistochemistry assay was performed on 10 cases of OSF, 10 cases of oral epithelial dysplasia (OED) and 8 cases of normal oral epithelium using monoclonal antibody against S100 protein.
  
  
  RESULTS
  S100 did not express in the normal oral muscosal epithelium. The S100 positive nuclear staining was found in 50% of the OSF and OED cases, which was significantly higher than that in the normal oral epithelium (P < 0.05). But the positive staining in the OSF and OED cases had no difference (P > 0.05).
  
  
  CONCLUSIONS
  S100 expression is closely related to the development of OSF and OED. The positive staining expression in the OSF and OED cases is the same.
authors.affiliation: Department of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China.
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Xie
authors.forename: Zhan-gui
authors.initials: ZG
authors.lastname: Tang
authors.forename: Zhi-gang
authors.initials: ZG
authors.lastname: Yao
mesh_terms: D006801:Humans; D007150:Immunohistochemistry; D009061:Mouth Mucosa / Q000378:metabolism* / Q000473:pathology; D009914:Oral Submucous Fibrosis / Q000378:metabolism*; D011230:Precancerous Conditions / Q000378:metabolism; D009418:S100 Proteins / Q000032:analysis / Q000378:metabolism*
chemical_list: D009418:S100 Proteins