Microbial transformation of baccatin VI and 1beta-hydroxy baccatin I by Aspergillus niger.
The biotransformation of baccatin VI (1) and 1beta-hydroxybaccatin I (2) with the filamentous fungus Aspergillus niger produced four new taxane diterpenoids taxumairol S(1) (3), taxumairol T(1) (4) and taxumairol S (5), taxumairol T (6), respectively. 1beta-Dehydroxybaccatin VI (7) remained unreacted under the same condition.
Shen
Ya-Ching
YC
Institute of Marine Resources, National Sun Yat-sen University, 70 Lien Hai Road, Kaohsiung 80424, Taiwan ROC. ycshen@mail.nsysu.edu.tw
Lo
Kuang-Liang
KL
Lin
Chun-Ling
CL
Chakraborty
Rupak
R
D000470:Alkaloids / Q000737:chemistry / Q000493:pharmacokinetics*; D001234:Aspergillus niger / Q000378:metabolism*; D001711:Biotransformation; D004224:Diterpenes / Q000493:pharmacokinetics; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000493:pharmacokinetics*; D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D043823:Taxoids / Q000493:pharmacokinetics; D014121:Toxoids / Q000737:chemistry / Q000493:pharmacokinetics*
C488272:1beta-hydroxy baccatin I; D000470:Alkaloids; D004224:Diterpenes; D006576:Heterocyclic Compounds, 4 or More Rings; D007202:Indicators and Reagents; D043823:Taxoids; D014121:Toxoids; C488271:baccatin VI