title: Polyethylene wear and acetabular component orientation.
abstract: BACKGROUND
  Polyethylene wear contributes substantially to both periprosthetic osteolysis and aseptic loosening after total hip arthroplasty. Acetabular component orientation has been shown to affect the range of motion of the hip as well as contact stresses. A series of studies was designed to test the hypothesis that acetabular component orientation can affect the magnitude and direction of polyethylene wear.
  
  
  METHODS
  A finite-element model was used to compute contact stresses during a normal gait cycle. Wear at the end of each gait cycle was calculated with use of the sliding-distance-coupled finite-element formulation. The wear that was calculated with use of finite-element analysis was validated by comparison with the findings of hip wear simulator studies with the acetabular liner oriented to simulate 45 degrees and 55 degrees of abduction. In a clinical study, fifty-six patients who underwent sixty hip arthroplasties with use of a single prosthetic design were followed for as long as five years. Radiographs were analyzed to measure the abduction angle of the acetabular component and polyethylene wear.
  
  
  RESULTS
  The finite-element analysis predicted increased peak contact stresses with an increased abduction angle and reduced peak contact stresses with an increased anteversion angle. Linear wear rates ranging from 0.036 to 0.045 mm/million cycles were also predicted, and increased acetabular abduction angles were predicted to be associated with higher linear wear rates. In the hip wear simulator studies, significantly different wear rates were found between the cups with acetabular abduction angles of 45 degrees and 55 degrees (mean, 17.2 compared with 21.7 mg/million cycles; p < 0.01). In the clinical study, radiographic analysis revealed significant correlation between the acetabular abduction angle and the linear polyethylene wear rate. A 40% increase in mean linear polyethylene wear was seen in cups with an abduction angle of >or=45 degrees. The direction of wear was more medial (by 9.4 degrees ) in cups with an abduction angle of <45 degrees.
  
  
  CONCLUSIONS
  All three studies presented here underlined the importance of optimizing the position of the acetabular component. Careful attention to acetabular position may help to minimize wear.
authors.affiliation: Orthopaedic Research Laboratories, Scripps Clinic Center for Orthopaedic Research and Education, La Jolla, CA 92037, USA.
authors.forename: Shantanu
authors.initials: S
authors.lastname: Patil
authors.forename: Arnie
authors.initials: A
authors.lastname: Bergula
authors.forename: Peter C
authors.initials: PC
authors.lastname: Chen
authors.forename: Clifford W
authors.initials: CW
authors.lastname: Colwell
authors.forename: Darryl D
authors.initials: DD
authors.lastname: D'Lima
mesh_terms: D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000295:instrumentation*; D001672:Biocompatible Materials / Q000627:therapeutic use*; D015331:Cohort Studies; D003198:Computer Simulation; D019544:Equipment Failure Analysis / Q000379:methods*; D005260:Female; D020342:Finite Element Analysis; D006621:Hip Joint / Q000503:physiopathology / Q000601:surgery; D006622:Hip Prosthesis; D006801:Humans; D007592:Joint Diseases / Q000503:physiopathology / Q000601:surgery; D020959:Polyethylene / Q000627:therapeutic use*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011475:Prosthesis Failure; D016059:Range of Motion, Articular / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; D020959:Polyethylene