title: Physicochemical evaluation of PLA nanoparticles stabilized by water-soluble MPEO-PLA block copolymers.
abstract: Different water-soluble MPEO-PLA diblock copolymers with various alpha-methoxy-omega-hydroxyl polyethylene (MPEO) and poly(lactic acid) (PLA) block lengths have been synthesized. Their surface-active properties were evidenced by surface tension (water/air) measurements. In each case the surface tension leveled down above a critical polymer concentration, which was attributed to the formation of a dense polymer layer at the liquid-air interface. The applicability of copolymers as emulsion stabilizers in the preparation of PLA nanospheres by an o/w emulsion/evaporation technique was then investigated. Four copolymers presenting sufficient water solubility and good surfactive properties were used to prepare PLA nanospheres with MPEO chains firmly anchored at the particle surface. The effect of polymer concentration in emulsion on particle size and surface coverage was examined. Whatever the copolymer characteristics, it was found that the optimal concentration to obtain a large amount of MPEO at the particle surface was similar (around 2 g/l). The effect of the copolymer composition on MPEO layer characteristics and on colloidal stability was also evaluated. The conformation of MPEO blocks at the PLA particle surface is discussed in relation to the layer thickness and the surface area occupied per molecule.
authors.affiliation: Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS-INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France.
authors.forename: D
authors.initials: D
authors.lastname: Chognot
authors.forename: J L
authors.initials: JL
authors.lastname: Six
authors.forename: M
authors.initials: M
authors.lastname: Leonard
authors.forename: F
authors.initials: F
authors.lastname: Bonneaux
authors.forename: C
authors.initials: C
authors.lastname: Vigneron
authors.forename: E
authors.initials: E
authors.lastname: Dellacherie