Synthesis of some functionalized arylaminomethyl-1 ,2,4-triazoles, 1,3,4-oxa- and thiadiazoles.
Thiosemicarbazides undergo different cyclization reactions to give five membered heterocycles. The product of cyclization depends on the reagent used. This cyclization leads to the formation of 1,3,4-oxadiazole, 1,3,4-thiadiazole and 1,2,4-triazole derivatives. The reaction of thioglycolyl hydrazide derivatives of the 1,2,4-triazole compounds was discussed. The activity against hepatitis B virus (HBV) has been tested.
Abdel-Aal
M T
MT
Department of Chemistry, Faculty of Science, Menoufia University, Shebin El Koam, Egypt.
El-Sayed
W A
WA
Abdel Aleem
A H
AH
El Ashry
E S H
ES
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004797:Enzyme-Linked Immunosorbent Assay; D006515:Hepatitis B virus / Q000187:drug effects; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
D000998:Antiviral Agents; D007202:Indicators and Reagents; D010080:Oxazoles; D013844:Thiazoles; D014230:Triazoles