GABA(A) receptor subunit and gephyrin protein changes differ in the globus pallidus in Huntington's diseased brain.
Immunoreactivity of GABA(A) receptor subunits and the receptor anchoring protein gephyrin was investigated in the human globus pallidus using antibodies raised against the alpha(1) and gamma(2) subunits of the GABA(A) receptor complex and gephyrin. The results revealed increased GABA(A) receptor subunit immunoreactivity and unchanged levels of gephyrin immunoreactivity in Huntington's diseased (HD) globus pallidus (GP). The results demonstrate that gephyrin immunoreactivity did not change in unison with GABA(A) receptor changes in HD, suggesting that the receptor anchoring protein gephyrin is unaltered and maintains a stable lattice structure in the face of GABA(A) receptor changes in HD.
Thompson-Vest
N M
NM
Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Waldvogel
H J
HJ
Rees
M I
MI
Faull
R L M
RL
D002352:Carrier Proteins / Q000378:metabolism*; D002452:Cell Count / Q000379:methods; D005917:Globus Pallidus / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006816:Huntington Disease / Q000473:pathology*; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000378:metabolism*; D021122:Protein Subunits / Q000378:metabolism*; D011963:Receptors, GABA-A / Q000378:metabolism*
D002352:Carrier Proteins; D008565:Membrane Proteins; D021122:Protein Subunits; D011963:Receptors, GABA-A; C073441:gephyrin