title: Comparative efficacy of flubendazole chewable tablets and a tablet combination of febantel, pyrantel embonate and praziquantel against Trichuris vulpis in experimentally infected dogs.
abstract: Fourteen of 23 dogs developing patent Trichuris vulpis infections by 120 days p.i. with 5000 embryonated eggs were allocated into three groups. One group was treated with flubendazole 220 mg chewable tablets (Flubenol) at the recommended dose regimen once daily for 3 days. The second group was given the recommended single treatment with a tablet containing 150 mg febantel, 144 mg pyrantel embonate and 50 mg praziquantel in combination (Drontal Plus). The third group remained untreated. All dogs were necropsied for worm counts 10 or 11 days after (first) treatment. No worms were recovered from the flubendazole treated dogs resulting in a significant worm count reduction of 100%. In contrast, 2 of 5 animals treated with the combination of febantel, pyrantel embonate and praziquantel remained infected; the geometric mean worm burden was reduced by 99.4% as compared to the control group but did not differ significantly from those of the controls.
authors.affiliation: Department of Veterinary Microbiology, Infectious and Parasitic Diseases, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria.
authors.forename: P N
authors.initials: PN
authors.lastname: Prelezov
authors.forename: C
authors.initials: C
authors.lastname: Bauer
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004359:Drug Therapy, Combination; D005260:Female; D006146:Guanidines / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008463:Mebendazole / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D011223:Praziquantel / Q000494:pharmacology / Q000627:therapeutic use; D011715:Pyrantel / Q000494:pharmacology / Q000627:therapeutic use; D013607:Tablets; D016896:Treatment Outcome; D014257:Trichuriasis / Q000188:drug therapy / Q000662:veterinary*; D014258:Trichuris / Q000187:drug effects*
chemical_list: D000969:Antinematodal Agents; D006146:Guanidines; D013607:Tablets; D011715:Pyrantel; D011223:Praziquantel; D008463:Mebendazole; C018945:flubendazole; C017309:febantel