Effects of increased concentrations of glucose on platelet reactivity in healthy subjects and in patients with and without diabetes mellitus.
Hyperglycemia has been linked to adverse outcomes after myocardial infarction. We characterized the effect of selected concentrations of glucose or mannitol on platelet function in whole blood samples from healthy volunteers and from patients with and without diabetes mellitus. Activation of platelet glycoprotein IIb/IIIa and P-selectin expression was increased similarly after addition of isosmotic concentrations of glucose and mannitol, suggesting that increased osmolarity associated with hyperglycemia increases platelet reactivity.
Keating
Friederike K
FK
Department of Medicine, University of Vermont, Burlington, Vermont 05446, USA. friederike.keating@vtmednet.org
Sobel
Burton E
BE
Schneider
David J
DJ
D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis*; D001792:Blood Platelets / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D006943:Hyperglycemia / Q000378:metabolism*; D008297:Male; D019007:P-Selectin / Q000378:metabolism; D015539:Platelet Activation / Q000502:physiology*
D001786:Blood Glucose; D019007:P-Selectin