title: Differences in genetic and transcriptional organization of the glpTQ operons between Haemophilus influenzae type b and nontypeable strains.
abstract: The glpTQ operon of Haemophilus influenzae type b (Hib) and nontypeable H. influenzae (NTHi) strains is highly conserved, except for a 1.4-kb glpTQ intergenic region that was found in most Hib strains. The presence of this intergenic region results in divergent glpTQ transcriptional profiles for Hib and NTHi where Hib strains appear to have evolved an alternative promoter for glpQ expression. Based on the intergenic region's low G+C content, we speculate that this DNA fragment was acquired by lateral transfer.
authors.affiliation: Vaccine & Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E3 Canada.
authors.forename: Xin-Ming
authors.initials: XM
authors.lastname: Song
authors.forename: Håkan
authors.initials: H
authors.lastname: Janson
mesh_terms: D001482:Base Composition; D001483:Base Sequence; D015964:Gene Expression Regulation, Bacterial; D019741:Haemophilus influenzae type b / Q000145:classification / Q000235:genetics*; D008969:Molecular Sequence Data; D016296:Mutagenesis; D009876:Operon / Q000235:genetics; D011401:Promoter Regions, Genetic; D012329:RNA, Bacterial / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D012329:RNA, Bacterial