title: [Endothelium derived relaxing factor and its effect on vascular disease].
abstract: The finding of endothelium derived relaxing factor (EDRF) and the illumination of its chemical identity, bio-synthesis and physiological functions promoted greatly the research on vascular disease. The EDRF was verified as NO or R-O-NO by many experimental results, and several pathological processes such as hypertension, atherosclerosis and heart failure were considered to be associated with abnormalities of endothellium-dependent vascular relaxation and decrease of basal EDRF and/or storage EDRF. As the provider of EDRF, Nitryl vascular relaxation substance could remedy EDRF and might play an important role in clinical therapy and prevention of human vascular disease.
authors.affiliation: College of Food and Bioengineering, South China University of Technology, Guangzhou 510640, China.
authors.forename: Jufang
authors.initials: J
authors.lastname: Wang
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Li
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D004285:Dogs; D045462:Endothelium-Dependent Relaxing Factors / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology; D011817:Rabbits; D051381:Rats; D013552:Swine; D014665:Vasodilator Agents / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D045462:Endothelium-Dependent Relaxing Factors; D014665:Vasodilator Agents; D009569:Nitric Oxide