Quantification of Human T-lymphotropic virus type I (HTLV-I) provirus load in a rural West African population: no enhancement of human immunodeficiency virus type 2 pathogenesis, but HTLV-I provirus load relates to mortality.
Human T-lymphotropic virus type I (HTLV-I) provirus load was examined in a cohort of a population in Guinea-Bissau among whom human immunodeficiency virus (HIV) type 2 is endemic. Geometric mean of HIV-2 RNA load among HTLV-I-coinfected subjects was significantly lower than that in subjects infected with HIV-2 alone (212 vs. 724 copies/mL; P=.02). Adjusted for age, sex, and HIV status, the risk of death increased with HTLV-I provirus load; mortality hazard ratio was 1.59 for each log10 increase in HTLV-I provirus copies (P=.038). There is no enhancing effect of HTLV-I coinfection on HIV-2 disease, but high HTLV-I provirus loads may contribute to mortality.
Ariyoshi
Koya
K
Medical Research Council Laboratories, Fajara, The Gambia. ariyoshi@nih.go.jp.
Berry
Neil
N
Cham
Fatim
F
Jaffar
Shabbar
S
Schim van der Loeff
Maarten
M
Jobe
Ousman
O
N'Gom
Pa Tamba
PT
Larsen
Olav
O
Andersson
Sören
S
Aaby
Peter
P
Whittle
Hilton
H
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000401:mortality / Q000821:virology*; D000328:Adult; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006169:Guinea-Bissau; D015498:HIV-2 / Q000472:pathogenicity*; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011533:Proviruses / Q000302:isolation & purification*; D012367:RNA, Viral / Q000032:analysis; D019562:Viral Load
D012367:RNA, Viral