Protein-peptide complexes of angiotensins in the mechanisms of thirst motivation.
A comparative analysis of the physiological actions of native angiotensin I and angiotensin II and protein-peptide complexes of angiotensin I and angiotensin II on drinking behavior in rats was performed. The protein-peptide complexes of angiotensin I and angiotensin II had wider spectra of physiological activity than the native peptides. Protein-conjugated angiotensin I, unlike the motivationally neutral native angiotensin I, produced marked activation of innate drinking behavior in mice. The protein-peptide complex of angiotensin II showed selective effects on acquired drinking behavior. These data are assessed with respect to the specific involvement of protein-peptide complexes of angiotensin I and angiotensin II in the mechanisms of thirst motivation during the performance of innate and acquired habits.
Kotov
A V
AV
P. K. Anokhin Science Research Institute of Normal Physiology, 4/11 Mokhovaya Street, 103009 Moscow, Russia.
Tolpygo
S M
SM
Pevtsova
E I
EI
Obukhova
M F
MF
D000803:Angiotensin I / Q000737:chemistry / Q000502:physiology*; D000804:Angiotensin II / Q000737:chemistry / Q000502:physiology*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal; D002216:Captopril / Q000494:pharmacology; D004327:Drinking Behavior / Q000187:drug effects; D004338:Drug Combinations; D007323:Instinct; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology; D013894:Thirst / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors; D004338:Drug Combinations; D000804:Angiotensin II; D012710:Serum Albumin, Bovine; D000803:Angiotensin I; D002216:Captopril