title: Genetic association between the phospholipase A2 gene and unipolar affective disorder: a multicentre case-control study.
abstract: The co-segregation in one pedigree of bipolar affective disorder with Darier's disease whose gene is on chromosome 12q23-q24.1, and findings from linkage and association studies with the neighbouring gene of phospholipase A2 (PLA2) indicate that PLA2 may be considered as a candidate gene for affective disorders. All relevant genetic association studies, however, were conducted on bipolar patients. In the present study, the possible association between the PLA2 gene and unipolar affective disorder was examined on 321 unipolar patients and 604 controls (all personally interviewed), recruited from six countries (Belgium, Bulgaria, Croatia, Germany, Greece, and Italy) participating in the European Collaborative Project on Affective Disorders. After controlling for population group and gender, one of the eight alleles of the investigated marker (allele 7) was found to be more frequent among unipolar patients with more than three major depressive episodes than among controls (P<0.01); genotypic association was also observed, under the dominant model of genetic transmission (P<0.02). In addition, presence of allele 7 was correlated with a higher frequency of depressive episodes (P<0.02). These findings suggest that structural variations at the PLA2 gene or the chromosomal region around it may confer susceptibility for unipolar affective disorder.
authors.affiliation: Athens University Medical School, Department of Psychiatry, Eginition Hospital, Athens, Greece. gnpapad@med.uoa.gr
authors.forename: George N
authors.initials: GN
authors.lastname: Papadimitriou
authors.forename: Dimitris G
authors.initials: DG
authors.lastname: Dikeos
authors.forename: Daniel
authors.initials: D
authors.lastname: Souery
authors.forename: Jurgen
authors.initials: J
authors.lastname: Del-Favero
authors.forename: Isabelle
authors.initials: I
authors.lastname: Massat
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Avramopoulos
authors.forename: Sylvie
authors.initials: S
authors.lastname: Blairy
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon
authors.forename: Sladjana
authors.initials: S
authors.lastname: Ivezic
authors.forename: Radka
authors.initials: R
authors.lastname: Kaneva
authors.forename: Georgia
authors.initials: G
authors.lastname: Karadima
authors.forename: Roberta
authors.initials: R
authors.lastname: Lilli
authors.forename: Vihra
authors.initials: V
authors.lastname: Milanova
authors.forename: Markus
authors.initials: M
authors.lastname: Nöthen
authors.forename: Lilijana
authors.initials: L
authors.lastname: Oruc
authors.forename: Marcella
authors.initials: M
authors.lastname: Rietschel
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
authors.forename: Christine
authors.initials: C
authors.lastname: Van Broeckhoven
authors.forename: Costas N
authors.initials: CN
authors.lastname: Stefanis
authors.forename: Julien
authors.initials: J
authors.lastname: Mendlewicz
mesh_terms: D016022:Case-Control Studies; D002874:Chromosome Mapping; D003866:Depressive Disorder / Q000235:genetics*; D005060:Europe; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D010741:Phospholipases A / Q000235:genetics*; D054467:Phospholipases A2
chemical_list: D010741:Phospholipases A; D054467:Phospholipases A2