title: [Barrett's esophagus: endoscopic treatment of high-grade dysplasia and early cancer].
abstract: In a Barrett's oesophagus without dysplasia, endoscopic control every 3-5 years is sufficient. If low-grade dysplasia is encountered in the surveillance biopsies, then endoscopy should be repeated within 3-6 months and yearly thereafter if the low-grade dysplasia persists. Antacid medication must be prescribed in cases with extensive inflammation. The endoscopic treatment of patients with high-grade dysplasia and/or early cancer of the mucosa in a Barrett's oesophagus (tissue ablation and/or mucosa resection) seems a promising alternative to surgery in view of the combination of effectiveness, limited invasiveness compared to surgical resection, and the preservation of a functional oesophagus. Data from long-term follow-up are still limited. Strict endoscopic surveillance will probably detect metachronic abnormalities in an early and still curable stage, creating a new opportunity for endoscopic treatment.
authors.affiliation: Afd. Maag-, Darm- en Leverziekten, Academisch Medisch Centrum, Meibergdreef 9, 1105 AZ Amsterdam. j.j.bergman@amc.uva.nl
authors.forename: J J
authors.initials: JJ
authors.lastname: Bergman
authors.forename: W A
authors.initials: WA
authors.lastname: Marsman
authors.forename: K K
authors.initials: KK
authors.lastname: Krishnadath
authors.forename: P
authors.initials: P
authors.lastname: Fockens
authors.forename: J J
authors.initials: JJ
authors.lastname: van Lanschot
authors.forename: G N
authors.initials: GN
authors.lastname: Tytgat
mesh_terms: D001471:Barrett Esophagus / Q000473:pathology / Q000601:surgery*; D001706:Biopsy; D004938:Esophageal Neoplasms / Q000473:pathology / Q000601:surgery*; D004945:Esophagoscopy / Q000379:methods*; D004947:Esophagus / Q000473:pathology; D006801:Humans; D009367:Neoplasm Staging; D011230:Precancerous Conditions / Q000473:pathology / Q000601:surgery*