Prothrombin G20210A mutation and sudden death.
The authors present a case of sudden death in a previously healthy 36-year-old male. At autopsy there were bilateral pulmonary thromboemboli and right ventricular dilatation. Histologic findings in the lungs included recanalized, old thrombi and evidence of pulmonary hypertension. Genetic analysis for hereditary risk factors was heterozygous positive for the prothrombin G20210A mutation. Implications of this finding, its history and the diagnostic technique shall be discussed. The authors recommend that all cases of deep venous thromboses and pulmonary thromboemboli lacking known risk factors be evaluated for newly described genetic variations associated with an increased risk for venous thrombosis.
Andrew
Thomas A
TA
Office of the Chief Medical Examiner of the State of New Hampshire, Concord, New Hampshire, USA. thomas.andrew@doj.nh.gov
Fairweather
Robert
R
D000328:Adult; D003645:Death, Sudden / Q000209:etiology*; D006579:Heterozygote; D006801:Humans; D017380:Hypertrophy, Right Ventricular / Q000473:pathology; D008297:Male; D009154:Mutation; D011516:Prothrombin / Q000235:genetics*; D011655:Pulmonary Embolism / Q000473:pathology
D011516:Prothrombin