title: Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase.
abstract: Functional evidence for programmed loss of co-linearity on the borrelidin modular polyketide synthase (PKS) is presented.
authors.affiliation: Departamento de Biología Funcional e Instituto Universitario de Oncologia del Principado de Asturias, Universidad de Oviedo, 33006 Oviedo, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Olano
authors.forename: Barrie
authors.initials: B
authors.lastname: Wilkinson
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Moss
authors.forename: Alfredo F
authors.initials: AF
authors.lastname: Braña
authors.forename: Carmen
authors.initials: C
authors.lastname: Méndez
authors.forename: Peter F
authors.initials: PF
authors.lastname: Leadlay
authors.forename: José A
authors.initials: JA
authors.lastname: Salas
mesh_terms: D000595:Amino Acid Sequence; D019677:Artificial Gene Fusion; D001483:Base Sequence; D005233:Fatty Alcohols / Q000737:chemistry / Q000378:metabolism; D005818:Genetic Engineering; D017434:Protein Structure, Tertiary
chemical_list: D005233:Fatty Alcohols; C005066:borrelidin