Mobile elements and mammalian genome evolution.
Mobile elements make up large portions of most eukaryotic genomes. They create genetic instability, not only through insertional mutation but also by contributing recombination substrates, both during and long after their insertion. The combination of whole-genome sequences and the development of innovative new assays to test the function of mobile elements have increased our understanding of how these elements mobilize and how their insertion impacts genome diversity and human disease.
Deininger
Prescott L
PL
Department of Environmental Health Sciences, Tulane University Health Sciences Center, New Orleans, LA 70112, USA. pdeinin@tulane.edu
Moran
John V
JV
Batzer
Mark A
MA
Kazazian
Haig H
HH
D000818:Animals; D005057:Eukaryotic Cells; D019143:Evolution, Molecular; D014644:Genetic Variation; D016678:Genome; D042822:Genomic Instability; D006801:Humans; D020071:Interspersed Repetitive Sequences; D008322:Mammals / Q000235:genetics*; D018626:Retroelements / Q000235:genetics*; D017422:Sequence Analysis, DNA
D018626:Retroelements