The inhibitory effect of ginseng saponins on the stress-induced plasma interleukin-6 level in mice.
The effect of ginseng saponins on plasma interleukin-6 (IL-6) in non-stressed and immobilization-stressed mice were investigated. Ginseng total saponins, ginsenosides Rb2, Rg1 and Rd administered intraperitoneally attenuated the immobilization stress-induced increase in plasma IL-6 level. But, intracerebroventricular injection of each ginsenoside did not affect plasma IL-6 level induced by immobilization stress. Ginsenosides Rb2, Rd and Rg1 significantly decreased norepinephrine and/or epinephrine-induced increase of IL-6 level in macrophage cell line (RAW 264.7). Thus, it can be suggested that the inhibitory action of ginseng saponins against the immobilization stress-induced increase of plasma IL-6 level would be in periphery; at least in part, mediated by blocking norepinephrine- and/or epinephrine-induced increase of IL-6 level in macrophage rather than in the brain. Ginseng saponins might be proposed as a possible candidate in the research or therapeutic modulation of stress-related disorders.
Kim
Do-Hoon
DH
Department of Psychiatry, College of Medicine, Institute of Natural Medicine, Hallym University, Chunchon, Kangwon-Do, 200-702, South Korea.
Moon
Yoo-Sun
YS
Lee
Tae-Hee
TH
Jung
Jun-Sub
JS
Suh
Hong-Won
HW
Song
Dong-Keun
DK
D000818:Animals; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes / Q000662:veterinary; D004347:Drug Interactions; D004837:Epinephrine / Q000494:pharmacology; D036145:Ginsenosides / Q000145:classification / Q000494:pharmacology*; D007103:Immobilization / Q000009:adverse effects; D007274:Injections, Intraperitoneal / Q000379:methods; D007276:Injections, Intraventricular / Q000379:methods; D015850:Interleukin-6 / Q000097:blood*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009638:Norepinephrine / Q000494:pharmacology; D005894:Panax / Q000737:chemistry*; D010949:Plasma / Q000187:drug effects* / Q000378:metabolism; D013312:Stress, Physiological / Q000097:blood*; D014662:Vasoconstrictor Agents / Q000494:pharmacology
D036145:Ginsenosides; D015850:Interleukin-6; D014662:Vasoconstrictor Agents; D009638:Norepinephrine; D004837:Epinephrine