title: Patients with essential hypertension present higher levels of sE-selectin and sVCAM-1 than normotensive volunteers.
abstract: In essential hypertension (EH) patients, blood pressure can modify serum concentrations of some soluble forms of cell adhesion molecules (CAM), e.g., soluble E-selectin (sE-selectin) and soluble vascular cell adhesion molecule-1 (sVCAM-1). The objective of this study was to compare the serum levels of these CAMs in compensated (CH) and non-compensated (NCH) EH patients. Our findings show that sE-selectin and sVCAM-1 levels are higher in EH patients than normotensive subjects (sVCAM-1: 796+/-52 vs. 605+/-24 ng/mL, p<0.0001, and sE-selectin: 71+/-21 vs. 48+/-14 ng/mL, p<0.0001). Serum concentrations of both CAMs was higher in NCH patients than CH patients. High arterial blood pressure (ABP) may therefore increase the production of cell adhesion molecules, probably through endothelial activation.
authors.affiliation: Department of Clinical Biochemistry and Immunohematology, School of Health Sciences, University of Talca, Talca, Chile. ipalomo@utalca.cl
authors.forename: Iván
authors.initials: I
authors.lastname: Palomo
authors.forename: Patricio
authors.initials: P
authors.lastname: Marín
authors.forename: Marcelo
authors.initials: M
authors.lastname: Alarcón
authors.forename: Gilda
authors.initials: G
authors.lastname: Gubelin
authors.forename: Ximena
authors.initials: X
authors.lastname: Viñambre
authors.forename: Eduardo
authors.initials: E
authors.lastname: Mora
authors.forename: Gloria
authors.initials: G
authors.lastname: Icaza
mesh_terms: D001794:Blood Pressure; D016022:Case-Control Studies; D019040:E-Selectin / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1