[Effects of soybean phospholipid on the content of malondialdehyde and lipofuscin in heart, liver and spleen in mice].
In order to observe the effects of soybean phospholipids on the SOD activity in liver and the content of malondialdehyde and lipofuscin in heart, liver and spleen in mice, forty male mice were divided into 4 groups. Experimental mice were fed with different doses of soybean phospholipids (2.5, 5 and 10 g/kg BW) and the control mice were fed with normal saline by tube feeding for 18 days. After that, the SOD activity in liver and the content of malondialdehyde and lipofuscin in heart, liver and spleen were measured. The results showed that the three doses of soybean phospholipid could significantly increased the SOD activity of liver (P < 0.05), and also could remarkably decrease the malondialdehyde content of in heart(P < 0.01) and in liver (P < 0.05). The soybean phospholipid at dose of 2.5 g/kg BW could significantly decrease the malondialdehyde content of in spleen(P < 0.05). But the three doses of soybean phospholipid did not obviously affect the content of lipofusin in liver, heart and spleen. The study indicated that the soybean phospholipid was effective on the inhibition of lipid peroxide.
Shao
Linxiang
L
College of Life and Environment, Zhejiang Normal University, Jinhua 321004, China.
Xu
Lishan
L
Liu
Ying
Y
Wang
Weiqiang
W
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008062:Lipofuscin / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D009206:Myocardium / Q000378:metabolism; D010743:Phospholipids / Q000494:pharmacology*; D013025:Glycine max; D013154:Spleen / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
D008062:Lipofuscin; D010743:Phospholipids; D008315:Malondialdehyde; D013482:Superoxide Dismutase