Cell polarity and Dictyostelium development.
Cell polarity is essential for unicellular and multicellular stages of Dictyostelium development. Chemotaxis during early development requires each cell to rapidly reorganize its cytoskeleton to point towards a source of cAMP. This involves a balance between local induction of F-actin polymerization and suppression of pseudopods that point in other directions. Both the lipid phosphatidylinositol (3,4,5) trisphosphate and the soluble signal cGMP have been implicated in these processes, in addition to conserved and novel proteins. During later development cells adopt newly discovered, alternative modes of movement and interact through adhesion molecules. Finally, cells polarize secretion to particular regions of their surface.
Williams
Hazel P
HP
MRC Laboratory for Molecular Cell Biology & Dept of Biology, University College London, Gower Street, London WC1E 6BT, UK.
Harwood
Adrian J
AJ
D000818:Animals; D016764:Cell Polarity; D004023:Dictyostelium / Q000166:cytology* / Q000254:growth & development*