title: [Isoniazid and rifampicin resistance and prior treatment for tuberculosis].
abstract: A case-control study in Rio de Janeiro in 1994 included 552 patients with a positive culture for Mycobacterium tuberculosis and reported a 1.8% resistance rate to rifampicin and isoniazid. Prior treatment for tuberculosis (the exposure factor) was associated with resistance. The binomial proportion was used to test the hypothesis of no dependence between the observed associations based on prior exposure to the drugs. This test showed a greater than expected dependence between resistances to rifampicin and isoniazid.
authors.affiliation: Centro de Referência Professor Hélio Fraga, Fundação Nacional de Saúde, Rio de Janeiro, RJ, 22710-552, Brasil. sonianatal@uol.com.br
authors.forename: Sonia
authors.initials: S
authors.lastname: Natal
authors.forename: Joaquim Gonçalves
authors.initials: JG
authors.lastname: Valente
authors.forename: Alexandra Roma
authors.initials: AR
authors.lastname: Sánchez
authors.forename: Maria Lúcia Fernandes
authors.initials: ML
authors.lastname: Penna
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use*; D008297:Male; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D012293:Rifampin / Q000627:therapeutic use*; D012307:Risk Factors; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid; D012293:Rifampin