title: [Non-convulsive epileptic status associated with Lafora disease: two case reports].
abstract: BACKGROUND
  Lafora s disease is a type of progressive myoclonic epilepsy with poor prognosis, is characterized by myoclonic crisis, tonic clonic seizures, absence or partial complex seizures and other neurological manifestations with a progressive course and a poor response to the treatment. It has not been considered as a cause of epileptic status.
  
  
  METHODS
  Two women without important past medical history with normal psychomotor development before their suffering, with manifestations of 2 years of evolution the first one and 8 years on the second case characterized by myoclonic generalized, partial complex seizures and progressive deterioration of the mental functions that joined to our institution in a non convulsive epileptic status and they featured with a different evolution. The first patient with favorable control of the event with a single medication and functionality recover later, the second one with torpid evolution complicated with an epileptic status convulsive widespread condition and a prolonged permanency in the unit of intensive therapy. In both patients the diagnosis of Lafora s disease was established based in the findings of the skin axilar biopsy.
  
  
  CONCLUSIONS
  We believe that Lafora s disease must be suspected as a probable cause of non convulsive epileptic status in patients with myoclonic epilepsy associated with other neurological manifestations and a refractary response to the medical treatment. The evolution and clinical response will depend on the evolutionary stage of the disease.
authors.affiliation: Servicio de Neurología, Instituto Nacional de Neurología y Neurocirugía, Mexico DF, Mexico.
authors.forename: E G
authors.initials: EG
authors.lastname: Lopez-Meza
authors.forename: F
authors.initials: F
authors.lastname: Cerda-Tellez
authors.forename: I M
authors.initials: IM
authors.lastname: Alanis-Guevara
authors.forename: M C
authors.initials: MC
authors.lastname: Fernández González-Aragón
authors.forename: L A
authors.initials: LA
authors.lastname: Ruano-Calderón
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D020192:Lafora Disease / Q000150:complications*; D013226:Status Epilepticus / Q000150:complications*