Animal behavior models of the mechanisms underlying antipsychotic atypicality.
This review describes the animal behavior models that provide insight into the mechanisms underlying the critical differences between the actions of typical vs. atypical antipsychotic drugs. Although many of these models are capable of differentiating between antipsychotic and other psychotropic drugs, only a few seem to be able to differentiate between typical and atypical antipsychotics, such as the paw test and the phencyclidine (PCP)-induced disruption of prepulse inhibition (PPI) of startle in rats. Moreover, there is an urgent need for animal models focusing more on the negative and the cognitive symptoms. Hence, improved animal models are crucial for developing better treatments for schizophrenia.
Geyer
Mark A
MA
Department of Psychiatry, University of California at San Diego, 9500 Gilman Drive, 0804, La Jolla, CA 92093-0804, USA. mgeyer@ucsd.edu
Ellenbroek
Bart
B
D000818:Animals; D014150:Antipsychotic Agents / Q000145:classification / Q000494:pharmacology* / Q000627:therapeutic use; D001058:Apomorphine / Q000494:pharmacology; D001307:Auditory Perception / Q000187:drug effects; D001362:Avoidance Learning / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects; D006801:Humans; D006948:Hyperkinesis / Q000139:chemically induced; D007858:Learning / Q000187:drug effects; D023421:Models, Animal; D009433:Neural Inhibition; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D013216:Reflex, Startle; D012559:Schizophrenia / Q000188:drug therapy; D012934:Social Isolation
D014150:Antipsychotic Agents; D016194:Receptors, N-Methyl-D-Aspartate; D001058:Apomorphine