title: [Comparative assessment of the WHO and Gilson histological classifications of prostatic neoplasms (taking into account data of ploidy studies)].
abstract: We estimated ploidometric nuclear parameters of predominating cell population in various prostatic adenocarcinomas in using WHO vs Glison classification to define advantages of the above classifications. Ploidometry provides information on cell composition and proliferative activity of cells. We observed greater ploidity in different grades of cell atypia. WHO histological classification by differentiation grade corresponds to ploidometric characterization of tumor cell populations but fails to reflect the presence of different histological types of the tumor. Currently introduced classification by Glison is more effective both diagnostically and prognostically as it reveals a dominant histological type of the tumor and shows other variants of tumor growth progression.
authors.forename: L V
authors.initials: LV
authors.lastname: Gundorova
authors.forename: G G
authors.initials: GG
authors.lastname: Avtandilov
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Zakhmatov
authors.forename: G I
authors.initials: GI
authors.lastname: Varentsov
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Borshch
mesh_terms: D000230:Adenocarcinoma / Q000145:classification* / Q000235:genetics* / Q000473:pathology; D002467:Cell Nucleus / Q000235:genetics; D006801:Humans; D008297:Male; D011003:Ploidies; D011471:Prostatic Neoplasms / Q000145:classification* / Q000235:genetics* / Q000473:pathology; D012189:Retrospective Studies; D014944:World Health Organization