title: Long-term genetic effects of radiation exposure.
abstract: To date, there has been little experimental knowledge on the genetic risks of human exposure to ionising radiation for humans. Recent data suggest that hypervariable tandem repeat minisatellite loci provide a useful and sensitive experimental approach for monitoring radiation-induced germline mutation in humans. Here, I review the results of studies on minisatellite mutation rates in human populations exposed to radioactive fallout after the Chernobyl accident and nuclear weapon tests in Kazakhstan.
authors.affiliation: Department of Genetics, University of Leicester, University Road, Leicester LE1 7RH, UK. yed2@le.ac.uk
authors.forename: Yuri E
authors.initials: YE
authors.lastname: Dubrova
mesh_terms: D004781:Environmental Exposure; D004784:Environmental Monitoring / Q000379:methods; D005260:Female; D030342:Genetic Diseases, Inborn / Q000000981:diagnostic imaging; D006801:Humans; D018598:Minisatellite Repeats / Q000528:radiation effects*; D011247:Pregnancy; D011839:Radiation, Ionizing; D018788:Radioactive Hazard Release / Q000145:classification; D011877:Radionuclide Imaging