title: Interstitial glycerol increase in microdialysis after glycerol enema.
abstract: Microdialysis allows the measurement of extracellular concentrations of various endogenous substances, such as excitotoxic amino acids or metabolic end products. Recent advances in microdialysis techniques have led to widespread use in patients with brain disorders. Microdialysis has proved to be a useful tool for monitoring cerebral biochemical metabolism and secondary brain damage in severe head injury, subarachnoid haemorrhage, stroke, and epilepsy. In our neurosurgical intensive care unit, microdialysis was performed on 42 patients. Four patients received a glycerol enema for therapy of a paralytic ileus. A glycerol peak was observed in both intracerebral and subcutaneous microdialysis occurring three to four hours after the glycerol enema in all four patients. The highest glycerol value was 1187micromol/l cerebral and 2997micromol/l in the subcutaneous tissue. Our study indicates that besides the measurement of serum osmolality and serum glycerol level, microdialysis may be an additional valuable tool to control glycerol therapy in patients with cerebral oedema and elevated intracranial pressure.
authors.affiliation: Department of Neurosurgery, Medical University Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany. jan.gliemroth@t-online.de
authors.forename: Jan
authors.initials: J
authors.lastname: Gliemroth
authors.forename: Stephan
authors.initials: S
authors.lastname: Klaus
authors.forename: Ludger
authors.initials: L
authors.lastname: Bahlmann
authors.forename: Anke
authors.initials: A
authors.lastname: Klöhn
authors.forename: Kai
authors.initials: K
authors.lastname: Duysen
authors.forename: Anja
authors.initials: A
authors.lastname: Reith
authors.forename: Hans
authors.initials: H
authors.lastname: Arnold
mesh_terms: D000328:Adult; D004733:Enema / Q000379:methods*; D005990:Glycerol / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007418:Intestinal Pseudo-Obstruction / Q000188:drug therapy; D008297:Male; D017551:Microdialysis / Q000379:methods; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D005990:Glycerol