title: Prognostic value of cardiac autonomic neuropathy independent and incremental to perfusion defects in patients with diabetes and suspected coronary artery disease.
abstract: We investigated the prognostic value of cardiac autonomic neuropathy (CAN) in relation to perfusion defects in 146 diabetic patients with suspected coronary artery disease. Perfusion defects and CAN were significant univariate predictors of death (p=0.05 and p<0.001, respectively) and cardiac events (p<0.001 and p<0.002, respectively). However, CAN remained a significant predictor of death and cardiac events after adjustment for perfusion defects (both p<0.02), and provided prognostic information incremental to that offered by perfusion defects alone (p<0.003 and p<0.006, respectively).
authors.affiliation: Department of Nuclear Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea.
authors.forename: Kyung-Han
authors.initials: KH
authors.lastname: Lee
authors.forename: Hong-Joo
authors.initials: HJ
authors.lastname: Jang
authors.forename: Young-Hwan
authors.initials: YH
authors.lastname: Kim
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Lee
authors.forename: Yearn Seong
authors.initials: YS
authors.lastname: Choe
authors.forename: Yong
authors.initials: Y
authors.lastname: Choi
authors.forename: Mun Gyu
authors.initials: MG
authors.lastname: Lee
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Lee
authors.forename: Byung-Tae
authors.initials: BT
authors.lastname: Kim
mesh_terms: D000367:Age Factors; D000368:Aged; D003324:Coronary Artery Disease / Q000150:complications / Q000503:physiopathology*; D003326:Coronary Circulation / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006321:Heart / Q000294:innervation*; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D011237:Predictive Value of Tests; D011379:Prognosis; D012044:Regression Analysis; D013997:Time Factors