title: Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia.
abstract: An International Working Group met to revise the diagnostic and response criteria for acute myelogenous leukemia originally published in 1990, as well as to provide definitions of outcomes and reporting standards to improve interpretability of data and comparisons among trials. Since the original publication, there have been major advances in our understanding of the biology and molecular genetics of acute leukemia that are clinically relevant and warrant incorporation into response definitions. Differences from the 1990 recommendations included a category of leukemia-free state, new criteria for complete remission, including cytogenetic and molecular remissions and remission duration. Storage of viable blasts for correlative studies is important for future progress in the therapy of these disorders.
authors.affiliation: Department of Hematology/Oncology, Georgetown University, Lombardi Cancer Center, 3800 Reservoir Rd, NW, Washington, DC 20007, USA. bdc4@georgetown.edu
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Cheson
authors.forename: John M
authors.initials: JM
authors.lastname: Bennett
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Kopecky
authors.forename: Thomas
authors.initials: T
authors.lastname: Büchner
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Willman
authors.forename: Elihu H
authors.initials: EH
authors.lastname: Estey
authors.forename: Charles A
authors.initials: CA
authors.lastname: Schiffer
authors.forename: Hartmut
authors.initials: H
authors.lastname: Doehner
authors.forename: Martin S
authors.initials: MS
authors.lastname: Tallman
authors.forename: T Andrew
authors.initials: TA
authors.lastname: Lister
authors.forename: Francesco
authors.initials: F
authors.lastname: Lo-Coco
authors.forename: Roel
authors.initials: R
authors.lastname: Willemze
authors.forename: Andrea
authors.initials: A
authors.lastname: Biondi
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Hiddemann
authors.forename: Richard A
authors.initials: RA
authors.lastname: Larson
authors.forename: Bob
authors.initials: B
authors.lastname: Löwenberg
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Sanz
authors.forename: David R
authors.initials: DR
authors.lastname: Head
authors.forename: Ryuzo
authors.initials: R
authors.lastname: Ohno
authors.forename: Clara D
authors.initials: CD
authors.lastname: Bloomfield
authors.forename: Francesco
authors.initials: F
authors.lastname: LoCocco
mesh_terms: D002986:Clinical Trials as Topic / Q000592:standards*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000145:classification / Q000175:diagnosis* / Q000628:therapy; D012074:Remission Induction; D014481:United States