Rig-1 a new member of Robo family genes exhibits distinct pattern of expression during mouse development.
The Robo genes encode a family of proteins that are the receptors for the midline repellent Slits and play a role in axon guidance. In addition to Robo1 and Robo2, Rig-1 has been recently identified in mouse as a novel member of the Robo family of proteins. As a first step in elucidating the role of Rig-1 during vertebrate development, we characterised the expression of Rig-1 by in situ hybridisation together with Robo1 and Robo2 in the spinal cord and other tissues of the mouse embryo. Our results show that Rig-1 has a dynamic pattern of expression in the developing CNS. In the spinal cord Rig-1 shows overlapping but distinct pattern of expression with Robo1 and Robo2.
Camurri
Laura
L
MRC Centre for Developmental Neurobiology, Molecular Neurobiology Department, 4th floor South Wing, New Hunt's House, King's College London, Guy's Campus, London Bridge, London SE1 1UL, UK.
Mambetisaeva
Elvira
E
Sundaresan
Vasi
V
D000818:Animals; D001921:Brain / Q000196:embryology / Q000378:metabolism; D004622:Embryo, Mammalian / Q000196:embryology / Q000378:metabolism*; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics*; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic / Q000235:genetics; D013116:Spinal Cord / Q000196:embryology / Q000378:metabolism; D000097905:Roundabout Proteins
D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D000097905:Roundabout Proteins; C498888:Robo2 protein, mouse; C118348:Robo3 protein, mouse