Human immunodeficiency virus in plasma and cervicovaginal secretions in Filipino women.
This study examined 30 HIV-infected women in Manila to assess the relationship between cervicovaginal and plasma HIV-1 viral load. An interview and gynaecologic examination was conducted and cervicovaginal lavage (CVL) and venous blood specimens were collected. HIV-1 RNA was detected in plasma samples of 24 patients (80%) and in CVL samples of 18 women (60%); 16 patients (53%) had detectable levels in both. CVL HIV-1 RNA was detectable in 75% of women (6/8) with plasma viral loads between 10,000 and 100,000 copies/mL and in 77% of women (10/13) with plasma viral loads higher than 100,000 copies/mL (P =0.0086). Among women with CD4 cell counts of less than 200, 200-500, and greater than 500/mm(3), CVL HIV-1 RNA was detected in 73%, 69%, and 17% of women, respectively (P =0.1428). HIV-1 RNA shedding in the genital tract was significantly associated with plasma viral load.
Natividad-Villanueva
G U
GU
University of Philippines, Philippine General Hospital Department of Obstetrics and Gynecology, Manila, Philippines.
Santiago
E
E
Manalastas
R M
RM
Brown
H W
HW
Ingersoll
J
J
Caliendo
A M
AM
Mayer
K H
KH
Cu-Uvin
S
S
D000328:Adult; D018791:CD4 Lymphocyte Count; D002584:Cervix Uteri / Q000378:metabolism / Q000821:virology*; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000097:blood*; D015497:HIV-1; D006801:Humans; D016015:Logistic Models; D015999:Multivariate Analysis; D010679:Philippines; D012367:RNA, Viral / Q000302:isolation & purification; D014621:Vagina / Q000378:metabolism / Q000821:virology*; D014626:Vaginal Smears; D019562:Viral Load
D012367:RNA, Viral