title: Serial analysis of gene expression provides new insights into regulatory T cells.
abstract: It is now possible to induce donor-specific transplantation tolerance in adult rodents using a number of therapeutic strategies. Such peripheral tolerance is maintained by regulatory CD4+ T cells, not only in transplantation models, but also in autoimmunity. Differential gene expression analyses have been used to identify potential new markers for regulatory T cells, aiming to reveal new insights into their mechanisms of action, and to find novel targets for therapeutic manipulation of the immune system.
authors.affiliation: Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. stephen.cobbold@path.ox.ac.uk
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Cobbold
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Adams
authors.forename: Luis
authors.initials: L
authors.lastname: Graca
authors.forename: Herman
authors.initials: H
authors.lastname: Waldmann
mesh_terms: D000818:Animals; D015415:Biomarkers; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism
chemical_list: D015415:Biomarkers