title: Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment.
abstract: Thymidine kinase-negative mutants of herpes simplex virus did not reactivate from latency in mouse trigeminal ganglia, even when their latent viral loads were comparable to those that permitted reactivation by wild-type virus. Thus, reduced establishment of latency does not suffice to account for the failure to reactivate.
authors.affiliation: Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan 70101, Republic of China.
authors.forename: Shih-Heng
authors.initials: SH
authors.lastname: Chen
authors.forename: Angela
authors.initials: A
authors.lastname: Pearson
authors.forename: Donald M
authors.initials: DM
authors.lastname: Coen
authors.forename: Shun-Hua
authors.initials: SH
authors.lastname: Chen
mesh_terms: D000818:Animals; D006561:Herpes Simplex / Q000821:virology; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009154:Mutation; D018139:Simplexvirus / Q000201:enzymology / Q000235:genetics / Q000502:physiology*; D013937:Thymidine Kinase / Q000235:genetics / Q000378:metabolism*; D012668:Trigeminal Ganglion / Q000821:virology*; D014775:Virus Activation; D017735:Virus Latency
chemical_list: D013937:Thymidine Kinase