Determination of selective biochemical variables in pregnant and lactating mice after stobadine administration.
The aim of this study was to investigate the effects of the oral administration of stobadine (STB), a neuro- and cardioprotective drug with high antioxidant properties, on selective biochemical variables in pregnant and lactating mice. STB was administered orally at a dose of 50 mg/kg from day 15 of gestation to day 21 of lactation. Creatinine and urea were determined in serum, while acidity, proteins, glucose, ketones, bilirubin, urobilinogen, blood and creatinine were determined in urine from females on days 0, 15 and 18 of gestation and on days 7, 14, 21, and 28 postpartum (pp). In the biochemical variables investigated, no significant differences in STB-treated animals compared with controls were recorded on any of the days studied. Histopathological examination of kidney tissue did not reveal any adverse effect of STB administration.
Navarová
J
J
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovakia. Jana.Navarova@savba.sk
Ujházy
E
E
Líska
J
J
Dubovický
M
M
D000284:Administration, Oral; D000818:Animals; D002243:Carbolines / Q000008:administration & dosage*; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007774:Lactation / Q000097:blood / Q000187:drug effects* / Q000378:metabolism* / Q000652:urine; D051379:Mice; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D002243:Carbolines; C100106:dicarbine