title: Self-association of okadaic acid upon complexation with potassium ion.
abstract: Okadaic acid (OA) is a toxin responsible for diarrhetic shellfish poisoning and is an extremely useful tool for studying processes that are regulated by phosphorylation, although the exact mechanism of action is still undetermined. We report on a study that proved the existence of OA in an unusual dimeric form when complexed with potassium ion. The proposed structure of this dimer is based on spectroscopic and conformational studies.
authors.affiliation: Instituto Universitario de Bio-Organica Antonio Gonzalez, Universidad de La Laguna, Astrofisico Francisco Sanchez 2, 38206 La Laguna, Tenerife, Spain.
authors.forename: Antonio H
authors.initials: AH
authors.lastname: Daranas
authors.forename: José J
authors.initials: JJ
authors.lastname: Fernández
authors.forename: Ezequiel Q
authors.initials: EQ
authors.lastname: Morales
authors.forename: Manuel
authors.initials: M
authors.lastname: Norte
authors.forename: José A
authors.initials: JA
authors.lastname: Gavín
mesh_terms: D000818:Animals; D000838:Anions; D004141:Dinoflagellida / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008387:Marine Toxins / Q000737:chemistry* / Q000302:isolation & purification; D008958:Models, Molecular; D019319:Okadaic Acid / Q000737:chemistry* / Q000302:isolation & purification; D011188:Potassium / Q000737:chemistry*; D012996:Solutions
chemical_list: D000838:Anions; D008387:Marine Toxins; D012996:Solutions; D019319:Okadaic Acid; D011188:Potassium