title: [Toxocological study of Guiera senegalensis Lam (Combretaceae)].
abstract: The study was based on an aqueous extract derived from a 60 degrees ethanolic tincture containing 0.032 g of dry matter per ml. The leaves of Guiera senegalensis Lam (Combretaceae) were collected in December 1991 at Nguekhokh a village within 20 km from Mbour (Senegal). The extract was administered for six months through daily forced-feeling at 2 g/kg to Wistar male and female rats whose weight at the beginning of the experiment tanged between 140 g and 180 g. The urine was analysed during the study and the animals were weighed every four weeks. At the end of the experiment, the animals were slaughtered and various analyses carried out. Haematological features in relation with erythropoiesis, haemoglobinogenesis and leucopoiesis, were studied in relation with renal and hepatic functions; biochemical features too. Some organs (heart, lungs, kidneys, brain, cerebellum, spleen and liver) were removed and examined in order to detect possible lesions following the experiment. Judging by the results, Guiera senegalensis Lam (Combretaceae), as used in the experiment, did not show any significant toxicity.
authors.affiliation: Laboratoire de Chimie Analytique et Toxicologie Faculté de Médecine et de Pharmacie/UCAD, Dakar.
authors.forename: A
authors.initials: A
authors.lastname: Diouf
authors.forename: A
authors.initials: A
authors.lastname: Cisse
authors.forename: S S
authors.initials: SS
authors.lastname: Gueye
authors.forename: V
authors.initials: V
authors.lastname: Mendes
authors.forename: T
authors.initials: T
authors.lastname: Siby
authors.forename: R M
authors.initials: RM
authors.lastname: Diouf Diop
authors.forename: E
authors.initials: E
authors.lastname: Bassene
mesh_terms: D000818:Animals; D001835:Body Weight; D029764:Combretaceae / Q000009:adverse effects / Q000506:poisoning; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004920:Erythropoiesis / Q000187:drug effects; D005260:Female; D007668:Kidney / Q000187:drug effects; D019891:Leukopoiesis / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D016488:Medicine, African Traditional; D010789:Phototherapy / Q000009:adverse effects; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology / Q000506:poisoning / Q000627:therapeutic use; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D012675:Senegal
chemical_list: D010936:Plant Extracts