title: [Combined preoperative xeloda and radiotherapy for lower rectal cancer].
abstract: OBJECTIVE
  To evaluate the effect of combined preoperative xeloda and pelvic radiotherapy on locally advanced lower rectal cancer.
  
  
  METHODS
  Sixty lower rectal cancer patients were divided randomly into two groups. 30 patients (Group A) were treated with operation alone and 30 patients (Group B) were treated with xeloda and radiotherapy before operation.
  
  
  RESULTS
  The operative resection, anal preservation and local recurrence rates were 86.66%, 33.33%, 15.38% in group A and 100%, 83.33%, 0% in group B (P < 0.05 and P < 0.01).
  
  
  CONCLUSIONS
  Combined preoperative xeloda and radiotherapy for lower rectal cancer is able to significantly improve the operative resection, anal preservation and decrease the local recurrence rates.
authors.affiliation: Department of General Surgery, Second Hospital of Shantou Medical College, Shantou University, Guangdong 515041, China.
authors.forename: Chao-ping
authors.initials: CP
authors.lastname: Zhuang
authors.forename: Ting-han
authors.initials: TH
authors.lastname: Li
authors.forename: Jun-wei
authors.initials: JW
authors.lastname: Wu
authors.forename: Gao-yang
authors.initials: GY
authors.lastname: Cai
mesh_terms: D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D000069287:Capecitabine; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects; D012004:Rectal Neoplasms / Q000628:therapy*
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil