The solid-phase conjugation of purpurin-18 with a synthetic targeting peptide.
It has been demonstrated that efficient site-specific coupling of the highly active photodynamic therapy sensitiser purpurin-18 to the synthetic targeting peptide G-G-V-K-R-K-K-K-P-G-Y-G can be achieved with greater than 85% purity.
Walker
Ian
I
Centre for Photobiology and Photodynamic Therapy, Department of Biochemistry and Molecular Biology, University of Leeds, LS2 9JT, Leeds, UK.
Vernon
David I
DI
Brown
Stanley B
SB
D016503:Drug Delivery Systems / Q000379:methods*; D009842:Oligopeptides / Q000032:analysis / Q000737:chemistry*; D017319:Photosensitizing Agents / Q000032:analysis / Q000737:chemistry*; D011166:Porphyrins / Q000032:analysis / Q000737:chemistry*
D009842:Oligopeptides; D017319:Photosensitizing Agents; D011166:Porphyrins; C059051:purpurin 18