title: [The relationship between silicosis and the polymorphism of HLA-DRB1 *, DQB1 * genes].
abstract: OBJECTIVE
  To investigate the relation between the susceptibility to silicosis and the polymorphism of HLA-DRB1 *, DQB1 * genes in Chinese Hans.
  
  
  METHODS
  HLA-DRB1 * and DQB1 * gene polymorphism were tested in 48 silicosis patients and 100 normal controls by using polymerase chain reaction of sequence-specific primers (PCR-SSP).
  
  
  RESULTS
  The allele frequencies of DRB1 * 1401 and DQB1 * 05 in silicosis patients were significantly higher than those in normal controls (chi 2 = 5.61, P = 0.0066, RR = 17.40; chi 2 = 10.70, P = 0.0011, RR = 3.81, respectively), while the allele frequency of DRB1 * 09 was significantly lower in silicosis patients than that in controls (chi 2 = 5.70, P = 0.0187, RR = 0.21). There was a significant difference between the patient group and control group.
  
  
  CONCLUSIONS
  HLA-DRB1 * 1401 and DQB1 * 05 may be the susceptible genes and HLA-DRB1 * 09 the protection gene of silicosis, both susceptibility and protection may be related to HLA-DR gene locus. The joint action of allele genes may affect the pathogenesis of silicosis.
authors.affiliation: Department of Clinical Laboratory, Attached Kai Luan Hospital of North China Coal Medical College, Tangshan 063000, China.
authors.forename: Baojun
authors.initials: B
authors.lastname: Yuan
authors.forename: Zhixin
authors.initials: Z
authors.lastname: Zhang
authors.forename: Hongfen
authors.initials: H
authors.lastname: Li
authors.forename: Yanhe
authors.initials: Y
authors.lastname: Chang
authors.forename: Zhizhong
authors.initials: Z
authors.lastname: Liu
authors.forename: Jimin
authors.initials: J
authors.lastname: Zou
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Shan
mesh_terms: D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012829:Silicosis / Q000235:genetics*
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains