title: Aspermytin A: a new neurotrophic polyketide isolated from a marine-derived fungus of the genus Aspergillus.
abstract: A new polyketide, aspermytin A (1), was isolated from a cultured marine fungus, Aspergillus sp., which was separated from the mussel, Mytilus edulis. Its structure was elucidated on the basis of their spectral data, and the absolute configuration of 1 was determined by the CD spectrum. Aspermytin A induced neurite outgrowth in rat pheochromocytoma (PC-12) cells at concentration of 50 microM.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, 920-0934, Kanazawa, Japan. sachiko@p.kanazawa-u.ac.jp
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tsukamoto
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Miura
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Tomihisa
authors.initials: T
authors.lastname: Ohta
mesh_terms: D000818:Animals; D001230:Aspergillus / Q000302:isolation & purification*; D049872:Bivalvia; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009414:Nerve Growth Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects / Q000502:physiology; D016716:PC12 Cells; D051381:Rats
chemical_list: D018942:Macrolides; D009414:Nerve Growth Factors