Osmotic drug delivery using swellable-core technology.
Swellable-core technology (SCT) formulations that used osmotic pressure and polymer swelling to deliver drugs to the GI tract in a reliable and reproducible manner were studied. The SCT formulations consisted of a core tablet containing the drug and a water-swellable component, and one or more delivery ports. The in vitro and in vivo performance of two model drugs, tenidap and sildenafil, formulated in four different SCT core configurations: homogeneous-core (single layer), tablet-in-tablet (TNT), bilayer, and trilayer core, were evaluated. In vitro dissolution studies showed that the drug-release rate was relatively independent of the core configuration but the extent of release was somewhat lower for the homogeneous-core formulation, particularly under non-sink conditions. The drug-release rate was slower with increasing coating thickness and decreasing coating permeability, and was relatively independent of the drug loading and the number and size of the delivery ports. The drug-release rates were similar for the two model drugs despite significant differences in their physicochemical properties. Tablet-recovery and pharmacokinetic studies conducted in beagle dogs showed that the in vivo release of drug from SCT formulations was comparable to the in vitro drug release.
Thombre
A G
AG
Pfizer Global R&D, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA. Avinash_G_Thombre@groton.pfizer.com
Appel
L E
LE
Chidlaw
M B
MB
Daugherity
P D
PD
Dumont
F
F
Evans
L A F
LA
Sutton
S C
SC
D000818:Animals; D002626:Chemistry, Pharmaceutical; D004285:Dogs; D016503:Drug Delivery Systems / Q000379:methods*; D008297:Male; D009997:Osmotic Pressure / Q000187:drug effects; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*
D011108:Polymers