Inhibitory effects of aqueous crude extract of Saffron (Crocus sativus L.) on chemical-induced genotoxicity in mice.
Saffron (dried stigmas of Crocus sativus L.), was evaluated in the mouse bone marrow micronucleus test for its possible protective effects against chromosomal damage induced by cisplatin (CIS), mitomycin-C (MMC) and urethane (URE). Three doses of saffron (25, 50 and 100 mg/kg body weight) were orally administered to mice for five consecutive days prior to administration of genotoxins under investigation. From the results obtained, it was evident that the administration of 50 and 100 mg saffron/kg body weight could significantly inhibit the in vivo genotoxicity of these genotoxins. However, all the three doses of saffron were effective in exerting a protective effect against urethane.
Premkumar
Kumpati
K
Department of Genetics, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai, India. pkumpati@yahoo.co.in
Abraham
Suresh K
SK
Santhiya
Sathiyavedu T
ST
Ramesh
Arabandi
A
D000818:Animals; D000970:Antineoplastic Agents; D001854:Bone Marrow Cells / Q000187:drug effects; D025063:Chromosome Disorders / Q000139:chemically induced / Q000517:prevention & control*; D002945:Cisplatin; D045424:Complex Mixtures / Q000008:administration & dosage / Q000494:pharmacology*; D027622:Crocus; D004249:DNA Damage / Q000187:drug effects*; D004195:Disease Models, Animal; D004900:Erythroblasts / Q000187:drug effects; D008297:Male; D051379:Mice; D016685:Mitomycin; D008517:Phytotherapy; D014520:Urethane
D000970:Antineoplastic Agents; D045424:Complex Mixtures; D014520:Urethane; D016685:Mitomycin; D002945:Cisplatin