Oral class III antiarrhythmics: what is new?
OBJECTIVE
This review describes the latest developments in the clinical usage of class III antiarrhythmics. It also discusses some new studies providing insight into the mechanism of action of these drugs.


RESULTS
New data suggest that amiodarone is one of the most effective drugs for management of ventricular as well as supraventricular tachyarrhythmias. As over the years we have learned to deal with the toxic side effects of this drug, the risk of bradyarrhythmias requiring placement of a pacemaker is becoming more significant. Sotalol was approved for treatment of atrial fibrillation and atrial flutter (AF). It was also found to be effective in management of postoperative AF. Dofetilide has been approved for the conversion and maintenance of sinus rhythm in AF; its role in ventricular arrhythmias remains unclear. Data are emerging regarding clinical efficacy of azimilide and dronedarone.


CONCLUSIONS
Management of arrhythmias in patients with structural heart disease remains a challenge. Class III antiarrhythmics are the mainstay of treatment in this group of patients.
Khan
Mazhar H
MH
Department of Medicine, Pennsylvania State University, College of Medicine, The Milton S. Hershey Medical Center, Hershey 17033, USA.
D000638:Amiodarone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D000077764:Dronedarone; D006801:Humans; D006827:Hydantoins; D007093:Imidazoles / Q000627:therapeutic use; D048289:Imidazolidines; D010627:Phenethylamines / Q000627:therapeutic use; D010879:Piperazines / Q000627:therapeutic use; D013015:Sotalol / Q000627:therapeutic use; D013449:Sulfonamides / Q000627:therapeutic use; D013617:Tachycardia, Supraventricular / Q000188:drug therapy*; D017180:Tachycardia, Ventricular / Q000188:drug therapy*; D016896:Treatment Outcome
D000889:Anti-Arrhythmia Agents; D006827:Hydantoins; D007093:Imidazoles; D048289:Imidazolidines; D010627:Phenethylamines; D010879:Piperazines; D013449:Sulfonamides; C067192:ibutilide; C086123:azimilide; D013015:Sotalol; D000077764:Dronedarone; D000638:Amiodarone; C063533:dofetilide