title: Virtual colonoscopy compared with conventional colonoscopy for stricturing postoperative recurrence in Crohn's disease.
abstract: BACKGROUND
  The place of virtual colonoscopy (VC) in patients with Crohn's disease (CD) requiring endoscopic follow-up after surgery is unknown. The authors compared findings from VC versus conventional colonoscopy (CC) for assessing the postoperative recurrence of CD.
  
  
  METHODS
  Sixteen patients with ileocolonic anastomosis for CD were prospectively enrolled from January 2001 to January 2002. Recurrence was assessed by CC according to Rutgeerts et al. VC was performed with a computed tomography scanner, with images examined by three radiologists who were unaware of the endoscopic findings.
  
  
  RESULTS
  CC showed perianastomotic recurrence in 15 of 16 patients. Perianastomotic narrowing or stenosis was detected by VC in 11 of these 15 patients. There were 11 true positive, 1 true negative, 0 false-positive, and 4 false-negative findings (73% sensitivity, 100% specificity, 100% positive predictive value, 20% negative predictive value, 75% accuracy). Among the eight patients showing a rigid stenosis of the anastomosis not allowing passage of the colonoscope, VC detected narrowing or stenosis in seven patients.
  
  
  CONCLUSIONS
  The current findings suggest that although the widespread use of VC in CD is currently not indicated because of possible false-negative findings, this technique may represent an alternative to CC in noncompliant postsurgical patients with a rigid stenosis not allowing passage of the endoscope.
authors.affiliation: Cattedra di Gastroenterologia, Dipartimento di Medicina Interna, Center of Excellence for the Study of the Genomic Risk of Complex Multifactoral Diseases, Università di Roma, Rome, Italy. biancone@med.uniroma2.it
authors.forename: Livia
authors.initials: L
authors.lastname: Biancone
authors.forename: Roberto
authors.initials: R
authors.lastname: Fiori
authors.forename: Claudio
authors.initials: C
authors.lastname: Tosti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Marinetti
authors.forename: Mario
authors.initials: M
authors.lastname: Catarinacci
authors.forename: Francesca
authors.initials: F
authors.lastname: De Nigris
authors.forename: Giovanni
authors.initials: G
authors.lastname: Simonetti
authors.forename: Francesco
authors.initials: F
authors.lastname: Pallone
mesh_terms: D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical / Q000009:adverse effects; D003106:Colon / Q000601:surgery; D023881:Colonography, Computed Tomographic; D003113:Colonoscopy; D003251:Constriction, Pathologic; D003424:Crohn Disease / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007082:Ileum / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis; D011237:Predictive Value of Tests; D012008:Recurrence; D012680:Sensitivity and Specificity