title: A qualitative research study of the evolution of symptoms in individuals identified as prodromal to psychosis.
abstract: Because schizophrenia is difficult to treat and exacts large personal and societal costs, there is an effort underway to identify adolescents and young adults at high risk for psychosis. Theory-derived criteria of subthreshold positive symptoms identify a "prodromal" or clinically at-risk population who have conversion rates to psychosis of 40 to 50% within one to two years. However, further characterization of the psychosis prodrome by qualitative research methods could increase the predictive value of the "prodromal" designation. We conducted open-ended interviews with 20 parents of prodromal adolescents that focused on changes observed. The narratives fell into two thematically distinct subgroups, identified as "declining" and "never normal." The prodromal adolescents described as "declining" had a higher subsequent rate of conversion to psychosis than did the "never normal" group. Although preliminary, these results suggest that a trajectory of change in personality, relationships, and behavior from an essentially normal baseline may be consistent with increased risk for psychosis among prodromal adolescents.
authors.affiliation: New York State Psychiatric Institute/Columbia University, 1051 Riverside Drive, New York, NY 10032, USA. cc788@columbia.edu
authors.forename: Cheryl
authors.initials: C
authors.lastname: Corcoran
authors.forename: Larry
authors.initials: L
authors.lastname: Davidson
authors.forename: Rachel
authors.initials: R
authors.lastname: Sills-Shahar
authors.forename: Connie
authors.initials: C
authors.lastname: Nickou
authors.forename: Dolores
authors.initials: D
authors.lastname: Malaspina
authors.forename: Tandy
authors.initials: T
authors.lastname: Miller
authors.forename: Thomas
authors.initials: T
authors.lastname: McGlashan
mesh_terms: D000293:Adolescent; D017028:Caregivers / Q000523:psychology; D018450:Disease Progression; D005195:Family Relations; D005260:Female; D006801:Humans; D007398:Interpersonal Relations; D007406:Interview, Psychological; D008297:Male; D016487:Parenting / Q000523:psychology; D010552:Personality Assessment / Q000706:statistics & numerical data; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011594:Psychometrics; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis* / Q000523:psychology; D012803:Sick Role; D012919:Social Behavior