Population-wide infant screening for HLA-based type 1 diabetes risk via dried blood spots from the public health infrastructure.
The frequency of type 1 diabetes mellitus (T1DM)-associated HLA DQ alleles in the U.S. Pacific Northwest is as high as in Scandinavia, which has the highest T1DM incidence in the world. The high regional rate of islet autoimmunity observed among DPT-1 relatives supports this notion. Fortunately, Washington State archives dried blood spots after legislature-mandated newborn screening. The Diabetes Evaluation in Washington (DEW-IT) study aims to show that population-based prospective prediction of T1DM by HLA genotype screening followed by autoantibody surveillance can be performed within the public health infrastructure.
Wion
Emily
E
Pacific Northwest Research Institute, Seattle, Washington, USA. ewion@prni.org
Brantley
Michael
M
Stevens
Jeff
J
Gallinger
Susan
S
Peng
Hui
H
Glass
Michael
M
Hagopian
William
W
D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening / Q000706:statistics & numerical data*; D011446:Prospective Studies; D015980:Public Health Practice; D012307:Risk Factors; D014861:Washington / Q000453:epidemiology
D006683:HLA-DQ Antigens