Association of alpha 2-macroglobulin polymorphisms and Alzheimer disease in Mainland Han Chinese.
This study used case-control method to investigate roles of two alpha 2-macroglobulin (A2M) polymorphisms, a 5-bp insertion/deletion (A2M-I/D) and an A-->G substitution (A2M-A/G), in the development of sporadic Alzheimer disease (AD) in Mainland Han Chinese. Our results showed a trend of lower D-carrying genotype frequency in APOE-epsilon 4 carrying AD patients than in corresponding control subjects (chi(2)=3.67, p=0.055). The ID/AA genotype frequency was lower in AD patients comparing with controls (chi(2)=4.04, p=0.044). In AD patients, the G-carrying genotype frequency was significantly higher in APOE-epsilon 4 carrier subgroup than in APOE-epsilon 4 non-carriers (chi(2)=7.38, OR=2.99, 95% CI: 1.33-6.71, p=0.007). These results indicated that A2M-D allele was probably a weak AD protective factor, and there was a possible interaction of APOE-epsilon 4 and A2M-G alleles to increase AD risk in Mainland Han Chinese.
Chen
Deng
D
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, The Chinese Academy of Medical Sciences and The Peking Union Medical College, Beijing 100005, People's Republic of China.
Zhang
Jun-Wu
JW
Zhang
Zhen-Xin
ZX
Wu
Ya-Ning
YN
Qu
Qiu-Ming
QM
D017668:Age of Onset; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D019943:Amino Acid Substitution; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017384:Sequence Deletion; D000511:alpha-Macroglobulins / Q000235:genetics*
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D000511:alpha-Macroglobulins