title: [Risk of underestimating platelet count because of the increase of mean platelet volume at the end of pregnancy].
abstract: We report the case of a pregnant woman for whom the platelet count (77 x 10(9)/L) was underestimated by Coulter STKS analyzer during the third trimester because of large platelets. The microscopic counting of platelets revealed an isolated thrombocytopenia (120 x 10(9)/L). When not pregnant, the patient has low but normal platelet count (155 x 10(9)/L) with high mean platelet volume (MPV > 12 fL). This case report recalls that concomitantly to the decrease in platelet count, the MPV significantly increases at the end of pregnancy. This poorly known phenomenon does not impair platelet count by blood cell analyzers in as much as the platelet volume is in the range of measurement but may be responsible for underestimation of the platelet count if the MPV is already high before pregnancy. We describe how to detect this anomaly and propose simple guidelines for thrombocytopenia in normal pregnancy.
authors.affiliation: Service d'hématologie biologique, CHU de Nancy, 54511 Vandoeuvre-Les-Nancy.
authors.forename: A
authors.initials: A
authors.lastname: Fohlen-Walter
authors.forename: E
authors.initials: E
authors.lastname: de Maistre
authors.forename: C
authors.initials: C
authors.lastname: Vigneron
authors.forename: T
authors.initials: T
authors.lastname: Lecompte
authors.forename: J F
authors.initials: JF
authors.lastname: Lesesve
mesh_terms: D000328:Adult; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D010976:Platelet Count / Q000592:standards*; D011247:Pregnancy / Q000097:blood*; D011263:Pregnancy Trimester, Third; D012306:Risk