Psychological stress and cortisol secretion in anhedonic alcoholic men.
We investigated plasma cortisol in a psychological stress paradigm in seven weaned anhedonic alcoholics in comparison with seven age-matched healthy controls. Alcoholics had significantly higher mean plasma cortisol at baseline and no increase following a psychological stress paradigm. Anhedonic alcoholics judged the experimental situation less agreeable than controls. Anhedonic alcoholics may have blunted cortisol response to psychological stress.
Marra
D
D
Département de Pharmacologie, Hôpital Pitié-Salpêtrière, 47, Bd de l'Hôpital, 75634 Paris 13, France.
Warot
D
D
Berlin
I
I
Hispard
E
E
Dally
S
S
D000328:Adult; D000342:Affective Symptoms / Q000097:blood* / Q000523:psychology*; D000437:Alcoholism / Q000097:blood* / Q000523:psychology* / Q000534:rehabilitation; D001143:Arousal / Q000502:physiology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010469:Perceptual Distortion / Q000502:physiology; D011340:Problem Solving / Q000502:physiology; D013067:Speech Perception / Q000502:physiology; D013315:Stress, Psychological / Q000097:blood / Q000150:complications*; D013695:Temperance / Q000523:psychology; D014705:Verbal Behavior / Q000502:physiology
D006854:Hydrocortisone