Amino acids as regulators of gene expression: molecular mechanisms.
Regulation of gene expression by nutrients in mammals is an important mechanism allowing them to adapt their physiological functions according to the supply of nutrient in the diet. It has been shown recently that amino acids are able to regulate by themselves the expression of numerous genes. CHOP, asparagine synthetase, and IGFBP-1 regulation following AA starvation will be described in this review with special interest in the molecular mechanisms involved.
Jousse
Céline
C
Unité de Nutrition et Métabolisme Protéique, Institut National de la Recherche Agronomique de Theix, 63122 Saint Genès Champanelle, France.
Averous
Julien
J
Bruhat
Alain
A
Carraro
Valérie
V
Mordier
Sylvie
S
Fafournoux
Pierre
P
D051701:Activating Transcription Factor 4; D000596:Amino Acids / Q000494:pharmacology* / Q000502:physiology*; D000818:Animals; D001217:Aspartate-Ammonia Ligase / Q000378:metabolism; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics / Q000378:metabolism; D019587:Dietary Supplements; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism; D013217:Starvation / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism; D051742:Transcription Factor CHOP; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
C497109:ATF4 protein, human; D000596:Amino Acids; D022762:CCAAT-Enhancer-Binding Proteins; C497249:DDIT3 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D014157:Transcription Factors; D051701:Activating Transcription Factor 4; D051742:Transcription Factor CHOP; D001217:Aspartate-Ammonia Ligase