The causes of Charcot-Marie-Tooth disease.
Charcot-Marie-Tooth (CMT) disease serves as the summary term for the most frequent forms of inherited peripheral neuropathies that affect motor and sensory nerves. In the last 12 years, 14 genes have been identified that cause different CMT subforms. The genes found initially are predominantly responsible for demyelinating and dysmyelinating neuropathies. Genes affected in axonal and rare forms of CMT have only recently been identified. In this review, we will focus on the currently known genes that are associated with CMT syndromes with regards to their genetics and function.
Young
P
P
Department of Neurology, University of Münster, Münster, Germany.
Suter
U
U
D002607:Charcot-Marie-Tooth Disease / Q000145:classification / Q000209:etiology* / Q000235:genetics; D018740:Genetic Heterogeneity; D006801:Humans; D009185:Myelin Proteins / Q000235:genetics* / Q000378:metabolism
D009185:Myelin Proteins; C073687:PMP22 protein, human