[Hypoxic therapy of arterial hypertension in patients with different variability of arterial pressure].
Sixty two patients with essential hypertension stage II were divided into two groups. 32 patients of group 1 received combined therapy including a course of inhalations of gas hypoxic mixture containing 10% oxygen and conventional medication (ACE inhibitors, beta-blockers, calcium antagonists, diuretics). 30 patients of group 2 (controls) were given medication alone. 24-h monitoring of arterial pressure (AP) and echocardiography suggested that high AP variability (APV) in hypertensive subjects leads to more significant changes in left ventricular and atrial structure and function typical for hypertensive heart. In high VAP, its night values are subnormal while daytime values are high in patients on combined medication and hypoxic therapy. The patients on standard medication had significantly low VAP at night while their daytime VAP tended to decrease. VAP positively correlated with hypertensive load. In high VAP hypoxic and drug therapies are less effective.
Simonenko
V B
VB
Ermolaev
A L
AL
Potievskaia
V I
VI
Stepaniants
O S
OS
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004232:Diuretics / Q000627:therapeutic use; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D008991:Monitoring, Physiologic; D010102:Oxygen Inhalation Therapy
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D004232:Diuretics