title: Problems and solutions in calculating quality-adjusted life years (QALYs).
abstract: The quality-adjusted life-year (QALY) is a measure of the value of health outcomes. Since health is a function of length of life and quality of life, the QALY was developed as an attempt to combine the value of these attributes into a single index number. The QALY calculation is simple: the change in utility value induced by the treatment is multiplied by the duration of the treatment effect to provide the number of QALYs gained. QALYs can then be incorporated with medical costs to arrive at a final common denominator of cost/QALY. This parameter can be used to compare the cost-effectiveness of any treatment. Nevertheless, QALYs have been criticised on technical and ethical grounds. A salient problem relies on the numerical nature of its constituent parts. The appropriateness of the QALY arithmetical operation is compromised by the essence of the utility scale: while life-years are expressed in a ratio scale with a true zero, the utility is an interval scale where 0 is an arbitrary value for death. In order to be able to obtain coherent results, both scales would have to be expressed in the same units of measurement. The different nature of these two factors jeopardises the meaning and interpretation of QALYs. A simple general linear transformation of the utility scale suffices to demonstrate that the results of the multiplication are not invariant. Mathematically, the solution to these limitations happens through an alternative calculation of QALYs by means of operations with complex numbers rooted in the well known Pythagorean theorem. Through a series of examples, the new calculation arithmetic is introduced and discussed.
authors.affiliation: Health Outcomes Research Unit, Eli Lilly & Co, Spain, Av, de Industria 30, 28108 Alcobendas, Spain. prieto_luis@lilly.com
authors.forename: Luis
authors.initials: L
authors.lastname: Prieto
authors.forename: José A
authors.initials: JA
authors.lastname: Sacristán
mesh_terms: D003362:Cost-Benefit Analysis; D006304:Health Status; D006801:Humans; D008962:Models, Theoretical; D019057:Quality-Adjusted Life Years