[Genetic predictors of left ventricular hypertrophy: do polymorphisms of peroxisome proliferator activated nuclear receptor genes play any role?].
OBJECTIVE
To assess possible associations of polymorphic markers of PPARA and PPARG2 genes with presence of left ventricular hypertrophy (LVH) in patients with hypertension.


METHODS
Patients with hypertension (n=163, mean age 60.93+/-0.82 years) with (n=110) and without (n=53) LVH.


METHODS
Echocardiography was used for evaluation of left ventricular mass and mass index and polymerase chain reaction - for identification of alleles and genotypes of polymorphic markers of ACE, NOS3, PPARA, PPARG2 genes.


CONCLUSIONS
There was no association between presence of LVH and polymorphic marker Pro12AIa. Carriers of 4a allele of a polymorphic marker ecNOS4a/4b of NOS3 gene, A allale of a polymorphic marker G7831A of ACE gene, and C allele of PPARA gene had significantly greater left ventricular myocardial mass index. Monofactorial regression analysis showed that degree of LVH was significantly related to age, duration of hypertension, maximal systolic blood pressure. No relationship was found between left ventricular mass index and smoking, maximal diastolic blood pressure, habitual systolic and diastolic blood pressure, duration of hypertension, presence of ischemic heart disease, diabetes. According to results of multifactorial analysis A allele of a polymorphic marker G7831A of ACE gene, age and maximal systolic blood pressure were while C allele of PPARA gene was not independently related to the presence of LVH.
Minushkina
L O
LO
Presidential Medical Center of Russia; ul. Marshala Timoschenko, 15, 121356 Moscow, Russia.
Brazhnik
V A
VA
Zateĭshchikov
D A
DA
Ignat'ev
I V
IV
Nosikov
V V
VV
Sidorenko
B A
BA
D005260:Female; D015870:Gene Expression / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors