title: Genome-wide linkage scan for the metabolic syndrome in the HERITAGE Family Study.
abstract: The metabolic syndrome involves multiple and interactive effects of genes and environmental factors. To identify chromosomal regions encoding genes possibly predisposing to the metabolic syndrome, we performed a genome-wide scan with 456 white and 217 black participants from 204 nuclear families of the HERITAGE Family Study, using regression-based, single- and multipoint linkage analyses on 509 markers. A principal component analysis was performed on 7 metabolic syndrome-related phenotypes. Two principal components, PC1 and PC2 (55% of the variance), were used as metabolic syndrome phenotypes. ANOVA was used to quantify the familial aggregation of PC1 and PC2. Family membership contributed significantly (P < 0.0023) to the variance in PC1 (r(2) = 0.38 in whites; r(2) = 0.55 in blacks) and PC2 (r(2) = 0.51; r(2) = 0.48). In whites, promising evidence for linkage (P < 0.0023) was found for PC1 (2 markers on 10p11.2) and PC2 (a marker on 19q13.4). Suggestive evidence of linkage (0.01 > P > 0.0023) appeared for PC1 (1q41 and 9p13.1) and PC2 (2p22.3). In blacks, promising linkage was found for PC2 on 1p34.1, and suggestive linkage was found on 7q31.3 and 9q21.1. The genome-wide scan revealed evidence for quantitative trait loci on chromosomal regions that have been previously linked with individual cardiovascular disease and type 2 diabetes risk factors. Some of these chromosomal regions harbor promising potential candidate genes.
authors.affiliation: Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA.
authors.forename: Ruth J F
authors.initials: RJ
authors.lastname: Loos
authors.forename: Peter T
authors.initials: PT
authors.lastname: Katzmarzyk
authors.forename: D C
authors.initials: DC
authors.lastname: Rao
authors.forename: Treva
authors.initials: T
authors.lastname: Rice
authors.forename: Arthur S
authors.initials: AS
authors.lastname: Leon
authors.forename: James S
authors.initials: JS
authors.lastname: Skinner
authors.forename: Jack H
authors.initials: JH
authors.lastname: Wilmore
authors.forename: Tuomo
authors.initials: T
authors.lastname: Rankinen
authors.forename: Claude
authors.initials: C
authors.lastname: Bouchard
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D044383:Black People / Q000235:genetics; D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage; D015894:Genome, Human; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D010641:Phenotype; D025341:Principal Component Analysis; D040641:Quantitative Trait Loci; D044465:White People / Q000235:genetics