title: Transsacral exenteration of fixed primary and recurrent anorectal cancer.
abstract: BACKGROUND
  Posteriorly fixed anorectal cancer is often considered incurable, but may be resectable using transsacral approaches.
  
  
  METHODS
  We reviewed 45 patients undergoing transsacral exenteration for this problem since 1983 to determine outcome of such surgery.
  
  
  RESULTS
  The group consisted of 38 men and 7 women; 17 had primary tumors, 28 had recurrent cancer: local excision, 1; low anterior resection, 11; or abdominoperineal resection, 16. Thirty-nine had prior XRT. Operative mortality was 4%. Severe pain was relieved in 16 of 22 (72%) patients. Crude recurrence rates are local 22%, local plus distant 11%, distant 16%. Five-year disease-free survival is 31% for primary disease, 32% for recurrence. Median survival is abdominoperineal resection recurrence, 24 months; primary cancer, 30 months; low anterior resection recurrence, 37 months.
  
  
  CONCLUSIONS
  Transsacral exenteration relieved pain in 70% of patients with fixed anorectal cancer, and led to long-term survival in 31% to 32%. Prognosis trended toward benefit for recurrence after low anterior resection.
authors.affiliation: Department of Surgery, University of Colorado Health Sciences Center, Denver, CO, USA.
authors.forename: Ricardo J
authors.initials: RJ
authors.lastname: Gonzalez
authors.forename: Martin D
authors.initials: MD
authors.lastname: McCarter
authors.forename: Tracy
authors.initials: T
authors.lastname: McDermott
authors.forename: Nathan W
authors.initials: NW
authors.lastname: Pearlman
mesh_terms: D000328:Adult; D000368:Aged; D001005:Anus Neoplasms / Q000401:mortality / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010385:Pelvic Exenteration / Q000009:adverse effects / Q000379:methods*; D011183:Postoperative Complications; D012004:Rectal Neoplasms / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate