title: Chronically implanted epineural electrodes for repeated assessment of nerve conduction velocity and compound action potential amplitude in rodents.
abstract: Implanted epineural electrodes were used for the longitudinal assessment of peripheral nerve conduction velocity (NCV) and compound action potential (CAP) amplitude in rats. Custom-fabricated stimulating and recording electrodes were sutured over the tibial and sciatic nerves, respectively, and were used for weekly recordings of CAP latency and amplitude. Intra-day variability of nerve conduction velocity measurements had coefficients of variation of less than 2% for same day recordings from individual subjects. A clear trend in recovery of the NCV values following implant was observed over the 7-week trial period. These results demonstrate that implanted epineural electrodes provide a reliable method for chronic, in vivo monitoring of nerve conduction parameters in rodents.
authors.affiliation: School of Kinesiology, Simon Fraser University, Burnaby, BC, Canada V5A 1S6.
authors.forename: Blake
authors.initials: B
authors.lastname: Murphy
authors.forename: Charles
authors.initials: C
authors.lastname: Krieger
authors.forename: Joaquin-Andres
authors.initials: JA
authors.lastname: Hoffer
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004594:Electrophysiology / Q000379:methods*; D008297:Male; D009431:Neural Conduction / Q000502:physiology*; D010525:Peripheral Nerves / Q000502:physiology* / Q000528:radiation effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D013997:Time Factors