title: Enantioselective synthesis of epoxides by alpha-deprotonation--electrophile trapping of achiral epoxides.
abstract: Enantioselective alpha-deprotonation of achiral epoxides 1, 21, and 26 using organolithiums in the presence of (-)-sparteine 2 and subsequent electrophile trapping gives access to enantioenriched trisubstituted epoxides 9-17, 22, 23, 27 and 28 (in up to 86% ee).
authors.affiliation: Dyson Perrins Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford, UK OX1 3QY. david.hodgson@chem.ox.ac.uk
authors.forename: David M
authors.initials: DM
authors.lastname: Hodgson
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Buxton
authors.forename: Iain D
authors.initials: ID
authors.lastname: Cameron
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Gras
authors.forename: Eirene H M
authors.initials: EH
authors.lastname: Kirton