Saliva secretory IgA antibodies against molds and mycotoxins in patients exposed to toxigenic fungi.
Upper respiratory exposure to different environmental antigens results first in the activation of mucosal immunity and production of IgA antibodies in different secretions including saliva. Despite this there is no study, which addresses secretory antibodies against molds and mycotoxins. The purpose of this study was to evaluate mold-specific salivary IgA in individuals exposed to molds and mycotoxins in a water-damaged building environment. Saliva IgA antibody levels against seven different molds and two mycotoxins were studied in 40 patients exposed to molds and in 40 control subjects. Mold-exposed patients showed significantly higher levels of salivary IgA antibodies against one or more mold species. A majority of patients with high IgA antibodies against molds exhibited elevation in salivary IgA against mycotoxins, as well. These IgA antibodies against molds and mycotoxins are specific, since using molds and mycotoxins in immune absorption could reduce antibody levels, significantly. Detection of high counts of molds in water-damaged buildings, strongly suggests the existence of a reservoir of mold spores in the environment. This viable microbial activity with specific mold and mycotoxin IgA in saliva may assist in the diagnosis of mold exposure. Whether mold and mycotoxin specific IgA antibodies detected in saliva are indicative of the role of IgA antibodies in the late phase of type-1 hypersensitivity reaction or in type-2 and type-3 delayed sensitivities is a matter that warrants further investigation.
Vojdani
Aristo
A
Immunosciences Lab., Inc., Section of Neuroimmunology, Beverly Hills, California 90211, USA. immunsci@ix.netcom.com
Kashanian
Albert
A
Vojdani
Elroy
E
Campbell
Andrew W
AW
D000328:Adult; D016902:Air Pollution, Indoor; D000908:Antibodies, Fungal / Q000378:metabolism*; D000946:Antigens, Fungal; D016022:Case-Control Studies; D015169:Colony Count, Microbial; D004783:Environmental Microbiology; D005658:Fungi / Q000276:immunology* / Q000472:pathogenicity; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology / Q000276:immunology; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D008875:Middle Aged; D009183:Mycotoxins / Q000276:immunology* / Q000633:toxicity; D016273:Occupational Exposure; D012463:Saliva / Q000276:immunology*
D000908:Antibodies, Fungal; D000946:Antigens, Fungal; D007071:Immunoglobulin A, Secretory; D009183:Mycotoxins