[The relationship between glutathione S-transferase M1 genotypes and lipid peroxidation in asbestos workers].
OBJECTIVE
To study the relationship between glutathione S-transferase M1 (GSTM1) genotypes and lipid peroxidation of asbestos workers.


METHODS
94 asbestos workers and 51 controls were selected as subjects. The general information, occupational history and individual habits were collected by questionnaires in all participants. The venous blood was sampled and the plasma was separated for the detection of malondialdehyde (MDA) level and lymphocytes for DNA isolation and GSTM1 genotyping.


RESULTS
MDA level was significantly higher in asbestos workers [(0.283 +/- 0.054) nmol/L] than that in controls [(0.163 +/- 0.053) nmol/L, P < 0.01], however, neither duration of exposure nor accumulated asbestos exposure dose was related to MDA levels; MDA levels in control workers with GSTM1 +/- genotype [(0.190 +/- 0.034) nmol/L] were significantly higher than that in control workers with GSTM1 +/+ genotype [(0.138 +/- 0.055) nmol/L, P < 0.01]. Among asbestos workers, the same trend could be found, but the differences was not significant(P > 0.05). When the workers were stratified by duration of exposure or accumulated asbestos exposure dose, MDA levels in individuals with GSTM1 -/- genotype were also higher than those with GSTM1 +/+ genotype, but the differences were also not significant(P > 0.05).


CONCLUSIONS
Both exposure to asbestos and deficiency of GSTM1 genotype were related to lipid peroxidation in workers, but the role of the former may be more important than that of the latter.
Yan
Lei
L
Department of Occupational and Environmental Health, School of Public Health, Peking University, Beijing 100083, China.
Wang
Qien
Q
Yin
Yanling
Y
Zhao
Xiaohong
X
Liu
Gangzhu
G
Yu
Fei
F
Wang
Yuejin
Y
Liu
Shijie
S
D001194:Asbestos / Q000009:adverse effects*; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000032:analysis; D016273:Occupational Exposure
D001194:Asbestos; D005982:Glutathione Transferase; D008315:Malondialdehyde