title: Traffic related air pollution and incidence of childhood asthma: results of the Vesta case-control study.
abstract: OBJECTIVE
  The Vesta project aims to assess the role of traffic related air pollution in the occurrence of childhood asthma.
  
  
  METHODS
  Case-control study conducted in five French metropolitan areas between 1998 and 2000. A set of 217 pairs of matched 4 to 14 years old cases and controls were investigated. An index of lifelong exposure to traffic exhausts was constructed, using retrospective information on traffic density close to all home and school addresses since birth; this index was also calculated for the 0-3 years age period to investigate the effect of early exposures.
  
  
  RESULTS
  Adjusted on environmental tobacco smoke, personal and parental allergy, and several confounders, lifelong exposure was not associated with asthma. In contrast, associations before age of 3 were significant: odds ratios for tertiles 2 and 3 of the exposure index, relative to tertile 1, exhibited a positive trend (1.48 (95%CI = 0.7 to 3.0) and 2.28 (1.1 to 4.6)), with greater odds ratios among subjects with positive skin prick tests.
  
  
  CONCLUSIONS
  These results suggest that traffic related pollutants might have contributed to the asthma epidemic that has taken place during the past decades among children.
authors.affiliation: Public Health Laboratory, School of Medicine, Nancy University, France. zmirou@nancy.inserm.fr
authors.forename: D
authors.initials: D
authors.lastname: Zmirou
authors.forename: S
authors.initials: S
authors.lastname: Gauvin
authors.forename: I
authors.initials: I
authors.lastname: Pin
authors.forename: I
authors.initials: I
authors.lastname: Momas
authors.forename: F
authors.initials: F
authors.lastname: Sahraoui
authors.forename: J
authors.initials: J
authors.lastname: Just
authors.forename: Y
authors.initials: Y
authors.lastname: Le Moullec
authors.forename: F
authors.initials: F
authors.lastname: Brémont
authors.forename: S
authors.initials: S
authors.lastname: Cassadou
authors.forename: P
authors.initials: P
authors.lastname: Reungoat
authors.forename: M
authors.initials: M
authors.lastname: Albertini
authors.forename: N
authors.initials: N
authors.lastname: Lauvergne
authors.forename: M
authors.initials: M
authors.lastname: Chiron
authors.forename: A
authors.initials: A
authors.lastname: Labbé
mesh_terms: D000367:Age Factors; D000393:Air Pollutants / Q000633:toxicity; D000397:Air Pollution / Q000009:adverse effects* / Q000706:statistics & numerical data; D001249:Asthma / Q000139:chemically induced* / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D014504:Urban Health; D001335:Vehicle Emissions / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D001335:Vehicle Emissions