title: [Detection of lymph node metastases of malignant melanoma by palpation and ultrasound].
abstract: OBJECTIVE
  Early detection of metastases of malignant melanoma has therapeutic implications. The aim of this study was to evaluate palpation and ultrasound examination in the diagnostics of lymph node metastases in locally advanced melanoma.
  
  
  METHODS
  83 patients suffering from melanoma (Clark level IV or V) were examined for lymph node metastases by palpation and sonography. Findings were compared to histopathologic results after lymph node extirpation if available or the findings at the next follow-up visit.
  
  
  RESULTS
  Lymph node metastases were confirmed histopathologically in 14 patients at the first study visit, in three others at the control visit. Sensitivity, specificity, positive and negative predictive values of palpation for the detection of metastases or suspicious nodes with increasing volume at follow-up in this population were 65%, 81%, 48%, and 89%, and of ultrasound 100%, 66%, 45%, and 100%, respectively.
  
  
  CONCLUSIONS
  Sonography of lymph nodes should be included as a standard procedure in the detection of metastases of locally advanced malignant melanoma.
authors.affiliation: Klinik und Poliklinik für Innere Medizin I, Klinikum der Universität, Regensburg.
authors.forename: Frank H
authors.initials: FH
authors.lastname: Klebl
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: Gelbmann
authors.forename: Irene
authors.initials: I
authors.lastname: Lammert
authors.forename: Thomas
authors.initials: T
authors.lastname: Bogenrieder
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Stolz
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schölmerich
authors.forename: Klaus
authors.initials: K
authors.lastname: Schlottmann
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000000981:diagnostic imaging; D008875:Middle Aged; D010173:Palpation; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging; D013997:Time Factors; D014463:Ultrasonography