title: Methotrexate treatment for tubal pregnancy. Criteria for medical approach.
abstract: OBJECTIVE
  The purpose of this retrospective study is to underline the indications for the use of systemic methotrexate (MTX) in tubal pregnancies.
  
  
  METHODS
  One hundred and four (n=104) consecutive women were treated in our Department for tubal pregnancy. The database analysis showed that after careful respect for inclusion criteria, the treatment chosen was the intravenous administration of MTX in 68 patients, whereas laparoscopy constituted the primary treatment in 36 patients. A single dose of MTX was intravenously administered, diluted in saline solution, with a dosage of 50 mg/m2 of body surface. Close serum beta-hCG monitoring was performed, and in the case of a short fall, a 2nd dose of methotrexate was submitted.
  
  
  RESULTS
  The overall success rate of MTX treatment was 91%; the 2nd dose of MTX was used in 12% of patients, whereas in only 6 out of 68 patients included in the medical treatment group a surgical approach for suspected tubal rupture was necessary.
  
  
  CONCLUSIONS
  Treatment with methotrexate is effective and safe in the presence of these criteria: patient hemodynamically stable, absence of tubal rupture sign and hemoperitoneum, an adnexal mass with a diameter < or = 5 cm, an amenorrhea < or = 6 weeks and HCG levels < or = 10,000 mIU/ml. Laparoscopy is indicated in diagnostic uncertainty, when MTX is not suggested, when adnexal mass is > 5 cm, or in patients in which beta-hCG levels was > 10,000 mIU/ml.
authors.affiliation: Department of Gynecology and Obstetrics, Second University of Naples, Naples, Italy. luigicobellis@yahoo.it
authors.forename: G
authors.initials: G
authors.lastname: Cobellis
authors.forename: G
authors.initials: G
authors.lastname: Pierno
authors.forename: E
authors.initials: E
authors.lastname: Pecori
authors.forename: C
authors.initials: C
authors.lastname: Scaffa
authors.forename: L
authors.initials: L
authors.lastname: Stradella
authors.forename: E M
authors.initials: EM
authors.lastname: Messalli
authors.forename: B
authors.initials: B
authors.lastname: Festa
authors.forename: L
authors.initials: L
authors.lastname: Cobellis
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000627:therapeutic use*; D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008727:Methotrexate / Q000627:therapeutic use*; D018579:Patient Selection; D011247:Pregnancy; D011274:Pregnancy, Tubal / Q000188:drug therapy*; D012189:Retrospective Studies
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D006063:Chorionic Gonadotropin; D008727:Methotrexate