Hydroxyurea-induced pneumonitis in a patient with chronic idiopathic myelofibrosis after prolonged drug exposure.
We describe a 63-yr-old patient diagnosed with chronic idiopathic myelofibrosis whose disease was treated with hydroxyurea for 2 yr. He developed respiratory symptoms that were extensively investigated including lung biopsy. Clinical, radiological and histological features were compatible with a diagnosis of hydroxyurea-induced pneumonitis. Following drug withdrawal there was remarkable improvement in clinical and radiological findings.
Wong
Chi C
CC
Department of Haematology, The Whittington Hospital, London, UK. c.wong@zen.co.uk
Brown
David
D
Howling
Sarah J
SJ
Parker
Norman E
NE
D003937:Diagnosis, Differential; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced* / Q000175:diagnosis; D055728:Primary Myelofibrosis / Q000150:complications / Q000188:drug therapy*
D006918:Hydroxyurea