A tyrosine-modified hypocrellin B with affinity for and photodamaging ability towards calf thymus DNA.
An enhanced photodamaging ability towards CT-DNA was achieved in a tyrosine-modified hypocrellin B by improving the affinity of the sensitizer to DNA.
Xia
Sheng Qin
SQ
Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.
Zhou
Jia Hong
JH
Chen
Jing Rong
JR
Wang
Xue Song
XS
Zhang
Bao Wen
BW
D000818:Animals; D001665:Binding Sites; D002417:Cattle; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004249:DNA Damage / Q000187:drug effects* / Q000528:radiation effects*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010100:Oxygen / Q000378:metabolism; D010569:Perylene / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D011809:Quinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013053:Spectrophotometry; D014443:Tyrosine / Q000737:chemistry*
D011809:Quinones; D014443:Tyrosine; D010569:Perylene; D004247:DNA; C427203:calf thymus DNA; D010100:Oxygen; C064522:hypocrellin B