Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids.
The oxidation of polyunsaturated fatty acids such as arachidonic and linoleic acid initiates a plethora of cell signaling pathways in animals and plants. The chemistry of the enzymatic oxidation has been investigated for several enzymes, most notably prostaglandin synthase and the lipoxygenases, revealing many surprises and impressive examples of enzymatic control of hydrogen atom abstraction and subsequent oxygenation.
McGinley
Chris M
CM
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Ave, Urbana, Illinois 61801, USA.
van der Donk
Wilfred A
WA
D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D006859:Hydrogen / Q000378:metabolism*; D008084:Lipoxygenase / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism
D005231:Fatty Acids, Unsaturated; D006859:Hydrogen; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases