title: The angiotensin-converting-enzyme insertion/deletion polymorphism is not related to venous thrombosis.
abstract: The insertion/deletion (I/D) polymorphism of the gene for angiotensin-converting-enzyme (ACE) is associated with ACE plasma levels and activity. Conflicting results have been reported about the relevance of this polymorphism for venous thrombosis. The aim of the present study was to analyze the role of this polymorphism for deep venous thrombosis. The study was designed as a case-control study, including 330 patients with documented deep venous thrombosis and 354 controls. ACE genotype was determined by size-analysis of polymerase chain reaction products. Results showed that, ACE genotype frequencies were similar between patients (II: 24.8%; ID: 43.3%; DD: 31.8%) and controls (II: 22.9%; ID: 50.6%; DD: 26.6%, P = 0.15). The adjusted odds ratio of carriers of the DD geno-type for venous thrombosis was 1.24 (95% confidence interval 0.90-1.80). The polymorphism was furthermore not associated with age at first thromboembolic event or the occurrence of pulmonary embolism. From these results, we can conclude that the ACE I/D polymorphism is not a significant risk factor for deep venous thrombosis.
authors.affiliation: Division of Angiology, Department of Medicine, Karl-Franzens University, Graz, Austria. herwig.koeppel@klinikum-graz.at
authors.forename: Herwig
authors.initials: H
authors.lastname: Köppel
authors.forename: Wilfried
authors.initials: W
authors.lastname: Renner
authors.forename: Alexander
authors.initials: A
authors.lastname: Gugl
authors.forename: Lisa
authors.initials: L
authors.lastname: Cichocki
authors.forename: Robert
authors.initials: R
authors.lastname: Gasser
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Wascher
authors.forename: Ernst
authors.initials: E
authors.lastname: Pilger
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D017353:Gene Deletion; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D020246:Venous Thrombosis / Q000235:genetics*
chemical_list: D007703:Peptidyl-Dipeptidase A