Juvenile onset psoriatic arthritis in a patient with X-linked agammaglobulinemia (Bruton's disease).
We describe a 47-year-old male patient suffering from X-linked (or Bruton's) agammaglobulinemia with severe psoriatic arthritis (PsA), which started in childhood. PsA has been previously described in T-cell defective disorders, such as HIV infection, but our observation demonstrates that this rheumatic disease can also occur in subjects with B-lymphocyte cell functional impairment. Chronic inflammatory (bacterial?) involvement of the bowel could represent a pathogenetic connection between X-linked agammaglobulinemia and PsA.
Palazzi
C
C
Division of Rheumatology, Villa Pini Clinic, Chieti, Italy. kaps57@virgilio.it
D'Amico
E
E
Cacciatore
P
P
Pennese
E
E
Petricca
A
A
Olivieri
I
I
D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D015535:Arthritis, Psoriatic / Q000150:complications* / Q000473:pathology; D040181:Genetic Diseases, X-Linked / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male