title: PET measures of pre- and post-synaptic cardiac beta adrenergic function.
abstract: Positron Emission Tomography was used to measure global and regional cardiac beta-adrenergic function in 19 normal subjects and 9 congestive heart failure patients. [(11)C]-meta-hydroxyephedrine was used to image norepinephrine transporter function as an indicator of pre-synaptic function and [(11)C]-CGP12177 was used to measure cell surface beta-receptor density as an indicator of post-synaptic function. Pre-synaptic, but not post-synaptic, function was significantly different between normals and CHF patients. Pre-synaptic function was well matched to post-synaptic function in the normal hearts but significantly different and poorly matched in the CHF patients studied. This imaging technique can help us understand regional sympathetic function in cardiac disease.
authors.affiliation: Department of Radiology, Box 356004, University of Washington, Seattle, WA 98195, USA.
authors.forename: Jeanne M
authors.initials: JM
authors.lastname: Link
authors.forename: John R
authors.initials: JR
authors.lastname: Stratton
authors.forename: Wayne
authors.initials: W
authors.lastname: Levy
authors.forename: Jeanne E
authors.initials: JE
authors.lastname: Poole
authors.forename: Steven C
authors.initials: SC
authors.lastname: Shoner
authors.forename: Werner
authors.initials: W
authors.lastname: Stuetzle
authors.forename: James H
authors.initials: JH
authors.lastname: Caldwell
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001342:Autonomic Nervous System Diseases / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging / Q000294:innervation; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000378:metabolism*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013569:Synapses / Q000000981:diagnostic imaging* / Q000378:metabolism*; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed / Q000379:methods
chemical_list: D011943:Receptors, Adrenergic, beta