title: Impulsive-like behavior in differential-reinforcement-of-low-rate 36 s responding in mice depends on training history.
abstract: Prior behavioral history in operant conditioning paradigms may induce impulsive-like responding as shown in rats. Little is known to what extent behavioral history influences subsequent behavior in mice, therefore the present study investigated the effects of lever-pressing under a fixed-ratio 5 schedule of reinforcement on subsequent differential-reinforcement-of-low-rate (DRL) 36 s performance in wild type mice compared to the behavior of 5-HT1B receptor knockout mice. Acquisition of both autoshaping and fixed-ratio 5 training was faster in 5-HT1B receptor knockout compared to wild type mice. Nevertheless, in the DRL 36 s procedure no differences were observed between genotypes. Both wild type and 5-HT1B receptor knockout mice displayed premature or impulsive-like responding in the DRL 36 s procedure, for example a peak location of responses around 20 s and high rates of responding. Taken together, the present data suggest that impulsive-like responding in the DRL 36 s procedure in mice depends on prior behavioral history.
authors.affiliation: Department of Anatomy, University Medical Center St Radboud, Geert Grooteplein 21, 6525 EZ Nijmegen, The Netherlands. t.pattij@anat.umcn.nl
authors.forename: Tommy
authors.initials: T
authors.lastname: Pattij
authors.forename: Laus M
authors.initials: LM
authors.lastname: Broersen
authors.forename: Stefanie
authors.initials: S
authors.lastname: Peter
authors.forename: Berend
authors.initials: B
authors.lastname: Olivier
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001923:Brain Chemistry / Q000235:genetics; D003216:Conditioning, Operant / Q000502:physiology*; D005838:Genotype; D007175:Impulsive Behavior / Q000235:genetics* / Q000378:metabolism / Q000523:psychology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D011930:Reaction Time / Q000235:genetics / Q000502:physiology; D044302:Receptor, Serotonin, 5-HT1B / Q000172:deficiency / Q000235:genetics; D012054:Reinforcement, Psychology; D012701:Serotonin / Q000378:metabolism
chemical_list: D044302:Receptor, Serotonin, 5-HT1B; D012701:Serotonin