Interleukin-10 gene promoter region polymorphisms in patients with type 1 diabetes and autoimmune thyroid disease.
Type 1 diabetes is a heterogeneous autoimmune disease and is frequently associated with other organ-specific autoimmune diseases, including autoimmune thyroid disease (AITD). Type 1 diabetic patients with AITD are known to show distinct clinical and immunological features from patients without AITD. This study investigated whether interleukin-10 (IL-10) gene promoter region polymorphisms are associated with susceptibility to type 1 diabetes and AITD. The frequency of -1082G/A, -819C/T, and -592C/A polymorphisms was analyzed in 54 type 1 diabetic patients with AITD, 74 type 1 diabetic patients without AITD, 124 nondiabetic patients with AITD, and 107 healthy subjects in a case-control study. No significant differences on the allele and genotype frequencies of three polymorphisms were found not only in type 1 diabetic patients with AITD compared with normal controls, but also between nondiabetic patients with AITD and healthy controls. The distribution of IL-10 gene haplotypes was also similar between both patient groups and normal controls. These results suggest that IL-10 gene promoter region polymorphisms are not associated with genetic susceptibility to type 1 diabetes and AITD.
Ide
Akane
A
First Department of Internal Medicine, Graduate School of Biochemical Sciences, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan.
Kawasaki
Eiji
E
Abiru
Norio
N
Sun
Fuyan
F
Fukushima
Tetsuya
T
Ishii
Reiko
R
Takahashi
Ryoko
R
Kuwahara
Hironaga
H
Fujita
Naruhiro
N
Kita
Atsushi
A
Imaizumi
Misa
M
Oshima
Katsuya
K
Usa
Toshiro
T
Uotani
Shigeo
S
Ejima
Eri
E
Yamasaki
Hironori
H
Ashizawa
Kiyoto
K
Yamaguchi
Yoshihiko
Y
Eguchi
Katsumi
K
D001327:Autoimmune Diseases / Q000150:complications / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000235:genetics*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D013959:Thyroid Diseases / Q000150:complications / Q000235:genetics*
D016753:Interleukin-10