Pitfalls in the assessment of disability in individuals with low-grade gliomas.
In this study, the presence of motor and cognitive disability is described in a cohort of patients with low-grade glioma recruited from a geographical area with a well-defined population located in the middle of Sweden. The study group consisted of 35 patients, of which 24 were evaluated by both a neurologist and a neuropsychologist, and 11 only by a neurologist. The test battery according to EFIT (Edinburgh Functional Impairment Test) was used by the neurologist to measure impairments of limb function, memory and speech. Patients were asked to self-evaluate their deficits in motor function and cognition by responding to a specific questionnaire. In addition, a neuropsychological test battery was used by an experienced neuropsychologist who had no previous contact with the patients. In general, motor impairment was mild and predominantly found in the upper limb. Neuropsychological assessment revealed moderate or severe cognitive impairment in more than half of the patients. This impairment was not detected by neurological examination, and only to some extent reported by the patients them selves. The results show statistical differences in cognitive function, memory and language as recorded by the three assessors. In conclusion, this study demonstrates the usefulness of neuropsychological assessment as a complement to neurological examination to detect cognitive dysfunction in patients with low-grade gliomas.
Påhlson
Anneli
A
Department of Neurology, University Hospital Orebro, Sweden.
Ek
Lena
L
Ahlström
Gerd
G
Smits
Anja
A
D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis*; D003072:Cognition Disorders / Q000175:diagnosis*; D004185:Disability Evaluation; D005260:Female; D005910:Glioma / Q000175:diagnosis*; D006801:Humans; D007806:Language Disorders / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000175:diagnosis*; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D012647:Self-Assessment