title: New cinnamylphenols from Dalbergia species with cancer chemopreventive activity.
abstract: Five new cinnamylphenols (1,3-diphenylpropenes), dalberatins A (1), B (2), C (3), D (4), and E (5), were isolated from plants of the Dalbergia species. They were characterized and tested for their inhibitory activities against Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The cinnamylphenols were found to show remarkably potent activities. The result of the present investigation indicated that some of these cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters).
authors.affiliation: Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan.
authors.forename: Chihiro
authors.initials: C
authors.lastname: Ito
authors.forename: Masataka
authors.initials: M
authors.lastname: Itoigawa
authors.forename: Tetsufumi
authors.initials: T
authors.lastname: Kanematsu
authors.forename: Nijsiri
authors.initials: N
authors.lastname: Ruangrungsi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Higashihara
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Hoyoku
authors.initials: H
authors.lastname: Nishino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Furukawa
mesh_terms: D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000956:Antigens, Viral / Q000187:drug effects; D035782:Dalbergia / Q000737:chemistry*; D006801:Humans; D016393:Lymphoma, B-Cell; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013785:Thailand
chemical_list: D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D010636:Phenols; D013755:Tetradecanoylphorbol Acetate