Tumbling down a different pathway to genetic instability.
Ulcerative colitis (UC), a chronic inflammatory condition associated with a predisposition to colon cancer, is frequently characterized by DNA damage in the form of microsatellite instability (MSI). A new report links inflammation in UC with increases in the DNA repair enzymes 3-methyladenine DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically, with increased MSI. These findings may represent a novel mechanism contributing to MSI in chronic inflammation.
Guo
Haiwei H
HH
Jospeh Gottstein Research Laboratory, Department of Pathology, University of Washington, Seattle 98195-7705, USA.
Loeb
Lawrence A
LA
D001483:Base Sequence; D003093:Colitis, Ulcerative / Q000235:genetics*; D004249:DNA Damage; D045647:DNA Glycosylases / Q000378:metabolism; D004260:DNA Repair; D043243:DNA Sequence, Unstable; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D018895:Microsatellite Repeats; D008954:Models, Biological; D008969:Molecular Sequence Data; D009154:Mutation
C021565:3-methyladenine-DNA glycosylase; D045647:DNA Glycosylases; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase