title: Rank-based statistical methodologies for quantitative trait locus mapping.
abstract: This article addresses the identification of genetic loci (QTL and elsewhere) that influence nonnormal quantitative traits with focus on experimental crosses. QTL mapping is typically based on the assumption that the traits follow normal distributions, which may not be true in practice. Model-free tests have been proposed. However, nonparametric estimation of genetic effects has not been studied. We propose an estimation procedure based on the linear rank test statistics. The properties of the new procedure are compared with those of traditional likelihood-based interval mapping and regression interval mapping via simulations and a real data example. The results indicate that the nonparametric method is a competitive alternative to the existing parametric methodologies.
authors.affiliation: Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599, USA. fzou@bios.unc.edu
authors.forename: Fei
authors.initials: F
authors.lastname: Zou
authors.forename: Brian S
authors.initials: BS
authors.lastname: Yandell
authors.forename: Jason P
authors.initials: JP
authors.lastname: Fine
mesh_terms: D003433:Crosses, Genetic; D016013:Likelihood Functions; D040641:Quantitative Trait Loci