title: Vaccinia virus recombinant expressing gene of tick-borne encephalitis virus non-structural NS1 protein elicits protective activity in mice.
abstract: A vaccinia virus recombinant containing the non-structural tick-borne encephalitis virus (TBEV) NS1 gene was developed. The recombinant expressed native dimeric form of the NS1 protein in infected cells and protected mice against lethal infection with TBEV.
authors.affiliation: Chumakov Institute of Poliomyelitis and Viral Encephalitides RAMS, Moscow, Russia.
authors.forename: M V
authors.initials: MV
authors.lastname: Khoretonenko
authors.forename: M F
authors.initials: MF
authors.lastname: Vorovitch
authors.forename: L G
authors.initials: LG
authors.lastname: Zakharova
authors.forename: G V
authors.initials: GV
authors.lastname: Pashvykina
authors.forename: N V
authors.initials: NV
authors.lastname: Ovsyannikova
authors.forename: J R
authors.initials: JR
authors.lastname: Stephenson
authors.forename: A V
authors.initials: AV
authors.lastname: Timofeev
authors.forename: A D
authors.initials: AD
authors.lastname: Altstein
authors.forename: A M
authors.initials: AM
authors.lastname: Shneider
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D002460:Cell Line; D004669:Encephalitis Viruses, Tick-Borne / Q000235:genetics / Q000276:immunology*; D004675:Encephalitis, Tick-Borne / Q000276:immunology* / Q000517:prevention & control* / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D015531:Radioimmunoprecipitation Assay; D015996:Survival Rate; D014616:Vaccinia virus / Q000235:genetics*; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; C100315:NS1 protein, Flavivirus; D017361:Viral Nonstructural Proteins; D014765:Viral Vaccines