title: 20-year experience with elderly donors in living renal transplantation.
abstract: OBJECTIVE
  This study evaluates the impact of living renal donors (LD) aged 60 years and older on graft performance and patient survival in an old-for-young constellation.
  
  
  METHODS
  We analyzed 144 consecutive LDs between January 1983 and December 2002 (19 patients 60+/125 controls).
  
  
  RESULTS
  Mean donor age in the 60+ group was 63.7 (+/- 2.6) years and 43.7 (+/- 9.0) years for the <60 group. Mean recipient age was 42.4 (+/- 15.2) years versus 32.6 (+/- 15.3) years HLA-A, -B, and DR-mismatches were 3.16 (+/- 1.3) for the 60+ group and 3.13 (+/- 1.7) for the controls (P = NS). Rejection episodes in the first year following LD did not differ (53% versus 33%, P =.25). Mean serum creatinine for 65+ versus <65 after 1, 3, and 12 months was 1.91 +/- 1.2 versus 1.48 +/- 0.85 mg/dL (P =.16), 1.82 +/- 0.89 versus 1.29 +/- 0.35 mg/dL (P <.05) and 1.80 +/- 0.31 versus 1.37 +/- 0.38 mg/dL (P <.05) and mean creatinine clearance at 12 months 62 versus 82 mL/min (P =.06). Censored 1-, 3-, and 5-year graft survival was 100% versus 95% (P = NS), 100% versus 93% (P = NS) and 100% versus 83% (P = NS) with no significant difference in the log-rank test for Kaplan Meier.
  
  
  CONCLUSIONS
  No impact of donor age was found for graft survival but function of the 65+ kidneys at 3 and 12 months was reduced. Living renal donors 60+ are acceptable for carefully allocated recipients.
authors.affiliation: Department of Urology, University Hospital, Charité University Berlin, Schumanstrasse 20-21, D-10098 Berlin, Germany. markus.giessing@charite.de
authors.forename: M
authors.initials: M
authors.lastname: Giessing
authors.forename: T
authors.initials: T
authors.lastname: Slowinski
authors.forename: S
authors.initials: S
authors.lastname: Deger
authors.forename: I
authors.initials: I
authors.lastname: Tuerk
authors.forename: S
authors.initials: S
authors.lastname: Schönberger
authors.forename: K
authors.initials: K
authors.lastname: Budde
authors.forename: S A
authors.initials: SA
authors.lastname: Loening
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D005190:Family; D005260:Female; D006085:Graft Survival / Q000502:physiology; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D019520:Living Donors / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome