FcgammaRIIB is differentially expressed during B cell maturation and in B-cell lymphomas.
FcgammaRIIB, a low affinity receptor for the Fc portion of immunoglobulin G (IgG), is thought to drive negative selection of B cells in germinal centers (GC) by inducing apoptosis upon interaction with immune complexes. Its expression was investigated by immunohistochemistry in 22 reactive lymphoid tissues and 112 B-cell lymphomas. Pre-GC mantle cells, marginal zone cells and their neoplastic counterparts expressed FcgammaRIIB. The B chronic lymphocytic leukaemia (B-CLL)/small lymphocytic lymphomas were also positive. Not detected in GC, FcgammaRIIB was expressed in 52% of follicular lymphomas and in 20% of diffuse large B cell lymphomas (DLBCL). In DLBCL, FcgammaRIIB expression was linked to transformation (P < 0.001). Re-analysis of a gene profile data set from the Lymphochip microarrays showed that FcgammaRIIB expression in the activated B-like DLBCL subgroup was higher than in the GC-like one (P < 0.04), and was associated with an adverse prognostic both in univariate (P < 0.003) and in multivariate analysis including the International Prognostic Indicator (IPI) (P < 0.01). Thus these results challenge the potential role of FcgammaRIIB during B-cell selection in GC, and suggest a prognostic value of FcgammaRIIB expression in DLBCL.
Camilleri-Broët
Sophie
S
Service d'Anatomie Pathologique, Hôtel Dieu, AP-HP, Université Paris VI, Paris, France. sophie.camilleri-broet@htd.ap-hop-paris.fr
Cassard
Lydie
L
Broët
Philippe
P
Delmer
Alain
A
Le Touneau
Agnès
A
Diebold
Jacques
J
Fridman
Wolf Herman
WH
Molina
Thierry Jo
TJ
Sautès-Fridman
Catherine
C
D015703:Antigens, CD / Q000378:metabolism*; D001402:B-Lymphocytes / Q000378:metabolism* / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D015536:Down-Regulation; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000378:metabolism* / Q000473:pathology; D008224:Lymphoma, Follicular / Q000378:metabolism* / Q000473:pathology; D017452:Receptors, IgG / Q000378:metabolism*; D016019:Survival Analysis
D015703:Antigens, CD; C080571:Fc gamma receptor IIB; D017452:Receptors, IgG