title: Clinical presentation of parvovirus B19 infection in children with aplastic crisis.
abstract: The records of 22 children with parvovirus B19-induced aplastic crisis were reviewed. The group consisted of 16 children with sickle cell hemoglobinopathies and 6 with hereditary spherocytosis. Children presented to the hospital 0.5 to 8 days (mean, 2.4 days) after the onset of symptoms. The children with sickle-cell disease presented earlier (mean, 1.4 days) than did children with hereditary spherocytosis (mean, 5 days; P = 0.02. Fever was the most common symptom, occurring in 73% of children. Rash did not occur in either group. Reticulocyte counts began to rise 1 week after onset of illness associated with a rise in parvovirus B19-specific IgG antibody. These data suggest that parvovirus B19 infection in children with sickle-cell hemoglobinopathies and heredity spherocytosis differs from infection in normal children.
authors.affiliation: School of Medicine and Biomedical Sciences, State University of New York at Buffalo, The Children's Hospital of Buffalo, USA.
authors.forename: Richard
authors.initials: R
authors.lastname: Kellermayer
authors.forename: Howard
authors.initials: H
authors.lastname: Faden
authors.forename: Mauro
authors.initials: M
authors.lastname: Grossi
mesh_terms: D000293:Adolescent; D000741:Anemia, Aplastic / Q000209:etiology* / Q000503:physiopathology*; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000175:diagnosis; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D016731:Erythema Infectiosum / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D011336:Probability; D012016:Reference Values; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D013103:Spherocytosis, Hereditary / Q000150:complications* / Q000175:diagnosis