3-hydroxypropionaldehyde: applications and perspectives of biotechnological production.
3-hydroxypropionaldehyde (3-HPA) forms, together with HPA-hydrate and HPA-dimer, a dynamic, multi-component system (HPA system) used in food preservation, as a precursor for many modern chemicals such as acrolein, acrylic acid, and 1,3-propanediol (1,3-PDO), and for polymer production. 3-HPA can be obtained both through traditional chemistry and bacterial fermentation. To date, 3-HPA has been produced from petrochemical resources as an intermediate in 1,3-PDO production. In vivo, glycerol is converted in one enzymatic step into 3-HPA. The 3-HPA-producing Lactobacillus reuteri is used as a probiotic in the health care of humans and animals. The biotechnological production of 3-HPA from renewable resources is desirable both for use of 3-HPA in foods and for the production of bulk chemicals. The main challenge will be the efficient production and recovery of pure 3-HPA.
Vollenweider
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Laboratory of Food Biotechnology, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, 8092 Zurich, Switzerland. sabine.vollenweider@ilw.agrl.ethz.ch
Lacroix
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D000171:Acrolein / Q000737:chemistry; D000179:Acrylates / Q000737:chemistry; D000447:Aldehydes; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000494:pharmacology; D001419:Bacteria / Q000378:metabolism*; D001709:Biotechnology / Q000379:methods; D004755:Enterobacteriaceae / Q000378:metabolism; D005285:Fermentation; D005520:Food Preservatives / Q000378:metabolism; D005985:Glyceraldehyde / Q000031:analogs & derivatives* / Q000378:metabolism*; D005990:Glycerol / Q000378:metabolism*; D006836:Hydro-Lyases / Q000378:metabolism*; D007778:Lactobacillus / Q000378:metabolism; D019936:Probiotics; D011407:Propane; D011409:Propylene Glycols / Q000378:metabolism
D000179:Acrylates; D000447:Aldehydes; D000900:Anti-Bacterial Agents; D005520:Food Preservatives; D011409:Propylene Glycols; C047158:3-hydroxypropionaldehyde; D005985:Glyceraldehyde; C041787:1,3-propanediol; D000171:Acrolein; D006836:Hydro-Lyases; C020671:glycerol dehydratase; C036658:acrylic acid; D005990:Glycerol; D011407:Propane