title: Preparative therapies used for those with Fanconi's anemia undergoing stem cell transplants and subsequent engraftment rates.
abstract: Fanconi anemia patients are often treated with stem cell transplants to prevent myelodysplastic changes or leukemic progression. A variety of preparative regimens have been utilized. A case of a 13-year-old child with Fanconi's anemia is presented to highlight the preparative therapy utilized, engraftment rates which have been seen and the incidence of graft-vs.-host disease (GvHD). A review of the literature suggests the most successful preparative therapies with the highest engraftment rates and also suggests the best GvHD regimens.
authors.affiliation: Department of Pediatrics, Division of Blood and Bone Marrow Transplantation, A. I. duPont Hospital for Children, Wilmington, DE 19803, USA.
authors.forename: Michael E
authors.initials: ME
authors.lastname: Trigg
authors.forename: Robert
authors.initials: R
authors.lastname: Bond
mesh_terms: D000293:Adolescent; D005199:Fanconi Anemia / Q000628:therapy*; D006801:Humans; D008297:Male; D033581:Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D019172:Transplantation Conditioning / Q000009:adverse effects / Q000379:methods*