Tandem or sequential coupling-IMDA cycloaddition approach to highly fused polycarbocycles.
The Diels-Alder cycloadduct made from 3,5-dibromo-2-pyrone and 2-bromo-styrene was successfully transformed stereoselectively into a series of novel benzotetracycles via a tandem or sequential Pd-catalyzed coupling-intramolecular Diels-Alder (IMDA) cycloaddition. The resulting polycarbocycles can be readily converted into a bicyclo[3.3.1]nonane system upon ozonolysis of the internal double bond.
Pang
Soo-Jin
SJ
Department of Chemistry, Hanyang University, Seoul 131-791, Korea.
Min
Soo-Hyun
SH
Lee
Haiwon
H
Cho
Cheon-Gyu
CG