Exploring the immunogenome with bioinformatics.
A better description of the immune system can be afforded if the latest developments in bioinformatics are applied to integrate sequence with structure and function. Clear guidelines for the upgrade of the bioinformatic capability of the immunogenetics laboratory are discussed in the light of more powerful methods to detect homology, combined approaches to predict the three dimensional properties of a protein and a robust strategy to represent the biological role of a gene.
de Bono
Bernard
B
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK. bdb@mrc-lmb.cam.ac.uk
Trowsdale
John
J
D000818:Animals; D019295:Computational Biology; D016678:Genome; D023281:Genomics / Q000379:methods*; D006801:Humans; D007125:Immunogenetics / Q000379:methods*; D011110:Polymorphism, Genetic / Q000235:genetics