Transfusion-related acute lung injury (TRALI) following allogeneic stem cell transplant for acute myeloid leukemia.
Transfusion-related acute lung injury (TRALI) is a serious complication of transfusion characterized by dyspnea, hypoxemia, hypotension, fever, and bilateral pulmonary infiltrates. Although the frequency is estimated at 1/1,120 to 1/5,000 transfusions, few cases have been reported after hematopoietic stem cell transplant. We report a case occurring in an allogeneic transplant recipient who developed acute respiratory distress and bilateral pulmonary infiltrates 2 hr after a platelet transfusion due to the presence of anti granulocyte antibody HNA-3a in the product. As there is a wide differential diagnosis for pulmonary infiltrates developing post transplant, TRALI may be under-recognized and should be considered in this setting.
Ganguly
Siddhartha
S
Center for Gene and Cell Therapy, Baylor College of Medicine, Houston, Texas 77030, USA.
Carrum
George
G
Nizzi
Frank
F
Heslop
Helen E
HE
Popat
Uday
U
D000208:Acute Disease; D000328:Adult; D000906:Antibodies / Q000032:analysis / Q000276:immunology; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000276:immunology; D017713:Platelet Transfusion / Q000009:adverse effects; D013902:Radiography, Thoracic; D012128:Respiratory Distress Syndrome / Q000000981:diagnostic imaging / Q000209:etiology / Q000276:immunology; D014184:Transplantation, Homologous / Q000009:adverse effects
D000906:Antibodies