title: Talc functionality as lubricant: texture, mean diameter, and specific surface area influence.
abstract: Talc is widely used as a glidant (flow regulator) for powders. This study highlights the characteristics that confer to talcs new end use properties in improving the lubrication function during compression. We studied the contribution of texture, mean diameter (D50), and specific surface area on the residual die pressure, the ejection pressure, the lubrication index, and the tablet hardness. Different textures were studied: microcrystalline, macrocrystalline, and moderately macrocrystalline talc grade. The compression parameters were improved according to the texture. D50 varies from 0.62 to 15 microm. As D50 decreases, the lubrication performance is improved. Finally, the specific surface area of talcs was studied. This last characteristic of talcs was shown as the most relevant parameter in determining lubrication ability.
authors.affiliation: GEFSOD EA 2631, Laboratoires de Pharmacie Galénique, Facultés des Sciences Pharmaceutiques, Toulouse, France.
authors.forename: J
authors.initials: J
authors.lastname: Ribet
authors.forename: K
authors.initials: K
authors.lastname: Poret
authors.forename: D
authors.initials: D
authors.lastname: Arseguel
authors.forename: D
authors.initials: D
authors.lastname: Chulia
authors.forename: F
authors.initials: F
authors.lastname: Rodriguez
mesh_terms: D005079:Excipients / Q000737:chemistry*; D008153:Lubrication; D008422:Materials Testing; D010316:Particle Size; D011208:Powders; D011312:Pressure; D013607:Tablets; D013627:Talc / Q000737:chemistry*
chemical_list: D005079:Excipients; D011208:Powders; D013607:Tablets; D013627:Talc