Analysis of the requirement for glycoprotein m in herpes simplex virus type 1 morphogenesis.
A mutant of herpes simplex virus type 1 lacking both glycoprotein M and glycoprotein E was marginally compromised in terms of its in vitro growth characteristics. This finding is in marked contrast to a similar mutant of the related alphaherpesvirus, pseudorabies virus (A. R. Brack, J. M. Dijkstra, H. Granzow, B. G. Klupp, and T. C. Mettenleiter, J. Virol. 73:5364-5372, 1999), and suggests that the glycoprotein requirements for virion assembly may vary among different members of this family of viruses.
Browne
Helena
H
Division of Virology, Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom. hb100@mole.bio.cam.ac.uk
Bell
Susanne
S
Minson
Tony
T
D000818:Animals; D002460:Cell Line; D002522:Chlorocebus aethiops; D006224:Cricetinae; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D009024:Morphogenesis; D014709:Vero Cells; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism*; D014771:Virion / Q000378:metabolism
D014759:Viral Envelope Proteins; C044768:glycoprotein E, herpes simplex virus type 1