title: Comparison between polarography and titrimetry methods for determination of ascorbic acid in pharmaceutical dosage forms.
abstract: In view of the widespread use of vitamin C several methods were developed for the determination of vitamin C in pharmaceutical preparation. Titrimetric and colorimetric methods commonly used to assay ascorbic acid. Unfortunately these methods have some failures regarding manipulative steps. Ascorbic acid oxidizes at DME and it can be a specific way with fewer steps in sample preparation in order to assay vitamin C. In this study a polarographic method was performed to determine ascorbic acid in several pharmaceutical dosage forms. The samples were prepared in oxalic acid solution and a standard addition method was performed during the experiments. The method has comparable precision compared with common method and it is even gave less error percent. Polarographic assay also is faster and easier to perform and could be used for routine determination.
authors.affiliation: Department of Pharmaceutical Chemistry, Mazandaran University of Medical Sciences, Sari, Iran.
authors.forename: F
authors.initials: F
authors.lastname: Pourmorad
authors.forename: S
authors.initials: S
authors.lastname: Honary
authors.forename: R
authors.initials: R
authors.lastname: Enayatifard
authors.forename: S
authors.initials: S
authors.lastname: Shahrbandi
mesh_terms: D001205:Ascorbic Acid / Q000032:analysis*; D004304:Dosage Forms; D004563:Electrochemistry; D011048:Polarography
chemical_list: D004304:Dosage Forms; D001205:Ascorbic Acid