title: Incidence of aspirin nonresponsiveness using the Ultegra Rapid Platelet Function Assay-ASA.
abstract: We report the incidence of aspirin nonresponsiveness in a prospective, multicenter registry (n=422 patients) to be 23% using the Ultegra Rapid Platelet Function Assay-ASA, and determined a history of coronary artery disease to be associated with twice the odds of being an aspirin nonresponder (odds ratio 2.01, 95% confidence interval 1.189 to 3.411, p=0.009). Further prospective studies are needed to correlate aspirin nonresponsiveness to adverse clinical events.
authors.affiliation: Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. jwang@partners.org
authors.forename: John C
authors.initials: JC
authors.lastname: Wang
authors.forename: Denise
authors.initials: D
authors.lastname: Aucoin-Barry
authors.forename: Deborah
authors.initials: D
authors.lastname: Manuelian
authors.forename: Rachele
authors.initials: R
authors.lastname: Monbouquette
authors.forename: Mark
authors.initials: M
authors.lastname: Reisman
authors.forename: William
authors.initials: W
authors.lastname: Gray
authors.forename: Peter C
authors.initials: PC
authors.lastname: Block
authors.forename: Elizabeth H
authors.initials: EH
authors.lastname: Block
authors.forename: Marc
authors.initials: M
authors.lastname: Ladenheim
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Simon
mesh_terms: D001241:Aspirin / Q000627:therapeutic use*; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D004351:Drug Resistance; D005260:Female; D006400:Hematocrit; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010976:Platelet Count; D010979:Platelet Function Tests / Q000379:methods; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012042:Registries
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin