title: Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats.
authors.affiliation: The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. pjkenny@scripps.edu
authors.forename: P J
authors.initials: PJ
authors.lastname: Kenny
authors.forename: N E
authors.initials: NE
authors.lastname: Paterson
authors.forename: B
authors.initials: B
authors.lastname: Boutrel
authors.forename: S
authors.initials: S
authors.lastname: Semenova
authors.forename: A A
authors.initials: AA
authors.lastname: Harrison
authors.forename: F
authors.initials: F
authors.lastname: Gasparini
authors.forename: G F
authors.initials: GF
authors.lastname: Koob
authors.forename: P D
authors.initials: PD
authors.lastname: Skoubis
authors.forename: A
authors.initials: A
authors.lastname: Markou
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D003042:Cocaine / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000523:psychology*; D004305:Dose-Response Relationship, Drug; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D012201:Reward; D014029:Tobacco Use Disorder / Q000523:psychology*
chemical_list: D018722:Nicotinic Agonists; D011725:Pyridines; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; D009538:Nicotine; C121465:6-methyl-2-(phenylethynyl)pyridine; D003042:Cocaine