Correlation between the numbers of naive T cells infused with blood stem cell allografts and the counts of naive T cells after transplantation.
Naive T cells after allogeneic hematopoietic cell transplantation are thought to originate from the engrafted hematopoietic cells. In this report, we show that there is a correlation between the number of naive CD4 T cells infused with peripheral blood stem cell grafts and the absolute number of peripheral naive CD4 T cells on day 30 (R = 0.65; P <.001), day 80 (R = 0.63; P <.001), and day 180 (R = 0.66; P <.001) after transplantation. These results suggest that in the first 6 months after transplantation, most naive CD4 T cells are derived from the naive T cells infused with the graft.
Storek
Jan
J
Fred Hutchinson Cancer Research Center and University of Washington, Seattle, Washington, USA. jstorek@fhcrc.org
Dawson
Monja A
MA
Maloney
David G
DG
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D018791:CD4 Lymphocyte Count; D019070:Cell Lineage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D013601:T-Lymphocytes / Q000166:cytology / Q000637:transplantation*; D013997:Time Factors; D014184:Transplantation, Homologous