title: Management of iatrogenic perforation.
abstract: Iatrogenic perforation of the gastrointestinal tract is a medical emergency and is inevitable. An endoscopist must maintain a high index of suspicion despite minimal or atypical symptoms and negative radiologic studies, because perforation is a complication with tremendous morbidity and mortality. The endoscopist must know how to manage this complication appropriately and to seek immediate surgical consultation. There is ongoing controversy about when a patient should undergo nonoperative or surgical therapy. An evidence-based approach to manage iatrogenic perforation is not possible. The trend in the modern era is to less invasive, nonoperative therapy, given advancements in ICU care and antibiotics. Laparoscopy or laparoscopic-assisted (minilaparotomy) surgery is also being increasingly used with outcomes comparable with conventional laparotomy. Experience and advancements in accessories have enabled endoscopic repair of iatrogenic perforation in many situations [84]. The management algorithms provided synthesize the pertinent literature into reasonable guidelines to follow. Ultimately, an individualized approach must be taken to manage the patient with an iatrogenic perforation.
authors.affiliation: Division of Digestive and Liver Diseases, University of Texas Southwestern Medical Center at Dallas, Room F.4.310, 5323 Harry Hines Boulevard, Dallas, TX 75390-8887, USA.
authors.forename: Rajesh V
authors.initials: RV
authors.lastname: Putcha
authors.forename: J Steven
authors.initials: JS
authors.lastname: Burdick
mesh_terms: D000465:Algorithms; D003106:Colon / Q000293:injuries; D016099:Endoscopy, Gastrointestinal; D006801:Humans; D007416:Intestinal Perforation / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D007421:Intestine, Small / Q000293:injuries; D007431:Intraoperative Complications / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D013270:Stomach / Q000293:injuries*