Isolation and expression pattern of three mouse homologues of chick Rgm.
Growth cones of developing neurons are guided to their targets by attractive and repulsive cues. We have isolated three mouse homologues of the chick 'repulsive guidance molecule', Rgm [Nature 419 (2002) 392], and characterized their expression patterns. RgmA and RgmB are predominantly expressed in the developing and adult central nervous system in distinct patterns with little overlap. The third member of the Rgm gene family, RgmC, shows exclusive expression in the muscle cell lineage. From sequence and expression data, we suggest RgmA to be the mouse orthologue of chick Rgm.
Schmidtmer
Jens
J
Max Planck Institute for Brain Research, Deutschordenstrasse 46, 60528 Frankfurt, Germany.
Engelkamp
Dieter
D
D000595:Amino Acid Sequence; D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal; D002490:Central Nervous System / Q000196:embryology / Q000378:metabolism; D002645:Chickens; D018076:DNA, Complementary / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification; D058851:GPI-Linked Proteins; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D008636:Mesencephalon / Q000196:embryology / Q000378:metabolism; D051379:Mice / Q000196:embryology / Q000235:genetics*; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010802:Phylogeny; D016548:Prosencephalon / Q000196:embryology / Q000378:metabolism; D012249:Rhombencephalon / Q000196:embryology / Q000378:metabolism; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D000071020:Hemochromatosis Protein
D015816:Cell Adhesion Molecules, Neuronal; D018076:DNA, Complementary; D058851:GPI-Linked Proteins; D009124:Muscle Proteins; D009419:Nerve Tissue Proteins; C483496:Rgma protein, mouse; C483497:Rgmb protein, mouse; C504414:HJV protein, mouse; D000071020:Hemochromatosis Protein