Anti-angiogenic and inhibitory activity on inducible nitric oxide production of the mushroom Ganoderma lucidum.
Fresh fruit bodies of Ganoderma lucidum were extracted with 70% ethanol at room temperature. The extract (GL) showed significant anti-angiogenic activity, which was detected using a chick embryo chorioallantoic membrane assay. GL significantly inhibited LPS-induced NO production in RAW 264.7 macrophages. These results support the anti-tumor effect of Ganoderma lucidum.
Song
Yun Seon
YS
Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, PO Box 131, Seoul 130-650, South Korea.
Kim
Sun-Hyoung
SH
Sa
Jae-Hoon
JH
Jin
Changbae
C
Lim
Chang-Jin
CJ
Park
Eun-Hee
EH
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D005638:Fruit; D066298:In Vitro Techniques; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D010936:Plant Extracts / Q000494:pharmacology; D020940:Reishi
D020533:Angiogenesis Inhibitors; D010936:Plant Extracts; D009569:Nitric Oxide