Electrophysiological interactions between striatal glutamatergic and dopaminergic systems.
Glutamatergic and dopaminergic systems play a primary role in frontal-subcortical circuits involved in motor and cognitive functions. Considerable evidence has emerged indicating that the complex interaction between these neurotransmitter systems within the dorsal striatum and nucleus accumbens is critically involved in the gating of information flow in these highly integrative brain regions. As a result, disruptions of the interaction between glutamate and dopamine has been proposed as a pathological basis for a number of disorders, including the pathophysiology of schizophrenia. In this chapter, we discuss recent studies that have significantly advanced our understanding of the reciprocal interactions between glutamatergic and dopaminergic systems within the striatal complex in the normal brain and in pathological states.
West
Anthony R
AR
Department of Neuroscience, Finch University of Health Sciences/The Chicago Medical School, North Chicago, Illinois 60064, USA. westa@finchcms.edu
Floresco
Stan B
SB
Charara
Ali
A
Rosenkranz
J Amiel
JA
Grace
Anthony A
AA
D000818:Animals; D004298:Dopamine / Q000502:physiology*; D004594:Electrophysiology; D018698:Glutamic Acid / Q000502:physiology*; D006801:Humans; D008606:Mental Processes / Q000502:physiology; D008636:Mesencephalon / Q000166:cytology / Q000502:physiology; D017072:Neostriatum / Q000166:cytology / Q000502:physiology*; D009475:Neurons, Afferent / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology; D009435:Synaptic Transmission / Q000502:physiology
D018698:Glutamic Acid; D004298:Dopamine