title: [The evaluation of thyroid nodules: is routine use of frozen-section examination necessary following preoperative fine-needle aspiration biopsy? ].
abstract: OBJECTIVE
  We evaluated the role of fine-needle aspiration biopsy as a single parameter in determining the extent of thyroidectomy and the necessity of routine use of frozen-section examination in patients with nodular thyroid disease.
  
  
  METHODS
  We reviewed 67 patients (40 females, 27 males; mean age 44 years; range 17 to 78 years) who underwent thyroidectomy for nodular thyroid disease. Preoperative fine-needle aspiration biopsy and intraoperative frozen-section examination were performed in 46 patients and 40 patients, respectively. The results were compared with histopathologic diagnoses.
  
  
  RESULTS
  Histopathologically, 25 patients (37.3%) had malignant and 42 patients (62.7%) had benign disease. The sensitivity, specificity, and diagnostic accuracy were 50%, 95%, and 77% for fine-needle aspiration biopsy, and 100%, 87%, and 91% for frozen-section examination, respectively.
  
  
  CONCLUSIONS
  In view of lower sensitivity and accuracy rates for fine-needle aspiration biopsy, the routine use of frozen-section examination seems to be necessary especially in cases with highly suggestive clinical findings of malignancy.
authors.affiliation: Department of Otolaryngology, Bayindir Hospital, Ankara, Turkey. leventsaydam@lycos.com
authors.forename: Levent
authors.initials: L
authors.lastname: Saydam
authors.forename: M Tayyar
authors.initials: MT
authors.lastname: Kalcioğlu
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kizilay
authors.forename: Mete Kaan
authors.initials: MK
authors.lastname: Bozkurt
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000379:methods / Q000592:standards*; D005260:Female; D005629:Frozen Sections; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011300:Preoperative Care; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy