title: Tenofovir-related Fanconi syndrome with nephrogenic diabetes insipidus in a patient with acquired immunodeficiency syndrome: the role of lopinavir-ritonavir-didanosine.
abstract: Tenofovir-related tubular damage, like all other recently reported cases, occurred in patients receiving the protease inhibitor (PI) ritonavir, often with lopinavir. Increased plasma concentrations of didanosine were also observed after the addition of tenofovir. It was suspected that tenofovir with PIs interacted with renal organic anion transporters, leading to nephrotoxic tubular concentrations of tenofovir and systemic accumulation of didanosine. Until there is a better understanding of these interactions, close monitoring is recommended for patients receiving tenofovir, PIs, and didanosine.
authors.affiliation: Internal Medicine, Cochin and Saint Vincent de Paul Hospital, Paris, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Rollot
authors.forename: Eve-Marie
authors.initials: EM
authors.lastname: Nazal
authors.forename: Laurence
authors.initials: L
authors.lastname: Chauvelot-Moachon
authors.forename: Charikleia
authors.initials: C
authors.lastname: Kélaïdi
authors.forename: Nathalie
authors.initials: N
authors.lastname: Daniel
authors.forename: Mona
authors.initials: M
authors.lastname: Saba
authors.forename: Sebastien
authors.initials: S
authors.lastname: Abad
authors.forename: Philippe
authors.initials: P
authors.lastname: Blanche
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy*; D000225:Adenine / Q000031:analogs & derivatives*; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D018500:Diabetes Insipidus, Nephrogenic / Q000150:complications*; D016049:Didanosine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005198:Fanconi Syndrome / Q000139:chemically induced / Q000150:complications*; D006801:Humans; D061466:Lopinavir; D008297:Male; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D011744:Pyrimidinones / Q000627:therapeutic use; D019438:Ritonavir / Q000627:therapeutic use; D000068698:Tenofovir
chemical_list: D019380:Anti-HIV Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D011744:Pyrimidinones; D061466:Lopinavir; D000068698:Tenofovir; D000225:Adenine; D016049:Didanosine; D019438:Ritonavir