title: Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c mice.
abstract: The T-box expressed in T cells gene (T-bet) is a member of the T-box family of transcription factors. T-bet-deficient mice show normal lymphoid development, but exhibit profound defects in their Th1-mediated immune responses. As the balance between Th1- and Th2-mediated immune responses plays a role in autoimmune-prone diseases, we have investigated the diabetes-related insulin autoantibody (IAA) and cellular immune responses (insulitis), in the absence of Th1 lineage commitment, in T-bet KO Balb/c mice, after immunization with the B9-23 insulin peptide. We have therefore investigated whether absence of the T-bet gene influences diabetes-related phenotypes in Balb/c T-bet KO mice.
authors.affiliation: Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, Denver, Colorado 80262, USA. eviemel@pasteur.fr
authors.forename: Evie
authors.initials: E
authors.lastname: Melanitou
authors.forename: Edwin
authors.initials: E
authors.lastname: Liu
authors.forename: Dongmei
authors.initials: D
authors.lastname: Miao
authors.forename: Liping
authors.initials: L
authors.lastname: Yu
authors.forename: Laurie H
authors.initials: LH
authors.lastname: Glimcher
authors.forename: George
authors.initials: G
authors.lastname: Eisenbarth
mesh_terms: D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D010641:Phenotype; D020825:T-Box Domain Proteins; D014157:Transcription Factors / Q000235:genetics*; D000098815:T-bet Transcription Factor
chemical_list: D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D014157:Transcription Factors