Discovery of novel PTP1b inhibitors.
A small library of 19 compounds was designed based on unique structural features of PTP1b. Utilizing electrospray ionization mass spectrometry (ESI-MS) to provide binding information about complexes of enzyme and small molecule ligands, two classes of lead compounds were discovered.
Ockey
Denise A
DA
Genentech, Inc., Department of Bioorganic Chemistry, One DNA Way, South San Francisco, CA 94080, USA. ockey@speakeasy.net
Gadek
Thomas R
TR
D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000378:metabolism; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods
D004791:Enzyme Inhibitors; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases