Efficiency of high-flux hemodialysis in the treatment of valproic acid intoxication.
Recently, highly efficient (i.e., high volume) dialysis systems have been successfully introduced for the treatment of critically ill patients in the intensive care unit. They also can be a safer, more effective, and less costly alternative to traditional extracorporal techniques in the treatment of severe intoxication. This holds true even if the substance to be eliminated is believed to be a poor candidate for dialysis treatment. We report a case of successful treatment of potentially life-threatening intoxication, with valproic acid (VPA) using a GENIUS batch dialysis system for combined standard and extended high-volume hemodialysis therapy. Concentration of VPA in the total collected dialysate were measured.
Kielstein
J T
JT
Division of Nephrology, Department of Clinical Chemistry, Medical School Hannover, Hannover, Germany. kielstein@yahoo.com
Woywodt
A
A
Schumann
G
G
Haller
H
H
Fliser
D
D
D000328:Adult; D000927:Anticonvulsants / Q000506:poisoning*; D006801:Humans; D008297:Male; D006435:Renal Dialysis / Q000009:adverse effects; D013406:Suicide, Attempted; D013921:Thrombocytopenia / Q000209:etiology; D014635:Valproic Acid / Q000506:poisoning*
D000927:Anticonvulsants; D014635:Valproic Acid