title: Binding of a homologous series of anthraquinones to DNA.
abstract: The DNA binding characteristics of a series of homologous 2,6-disubstituted anthraquinone threading intercalators bearing one to four ethylene glycol units in their side chains have been studied. Binding constants were measured via surface plasmon resonance (SPR). These compounds bind to an AT-rich hairpin with slightly higher affinity than to a GC-rich hairpin. The binding constants decrease as the length of the side chain increases.
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, GA 30303, USA.
authors.forename: Ruel E
authors.initials: RE
authors.lastname: McKnight
authors.forename: Jianguo
authors.initials: J
authors.lastname: Zhang
authors.forename: Dabney W
authors.initials: DW
authors.lastname: Dixon
mesh_terms: D000880:Anthraquinones / Q000138:chemical synthesis* / Q000378:metabolism*; D001665:Binding Sites; D004247:DNA / Q000378:metabolism*; D007364:Intercalating Agents / Q000378:metabolism*
chemical_list: D000880:Anthraquinones; D007364:Intercalating Agents; D004247:DNA