[Importance of cell cultures in biocompatible dental materials research].
The need for biocompatible materials implies the necessity of toxicity testing. The toxicity of a dental material can be evaluated by in vitro tests, by animal experimentation including usage tests, and by clinical studies in humans. In vitro studies are mainly performed to evaluate the cytotoxicity (cell damage) or the genotoxicity (specific DNA damage or chromosomal aberration) of a dental material. Cell or tissue cultures play an important role because they allow a maximum standardization. This paper describes their application and interpretation of results in biocompatibility tests.
Nahid
Mohebbian
M
Département de Dentisterie Restauratrice, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Bruxelles.
Bottenberg
Peter
P
D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D018929:Cell Culture Techniques / Q000379:methods*; D002478:Cells, Cultured / Q000187:drug effects; D003764:Dental Materials / Q000633:toxicity*; D018865:Dental Research / Q000379:methods*; D006801:Humans; D008422:Materials Testing / Q000379:methods; D018675:Toxicity Tests / Q000379:methods*
D001672:Biocompatible Materials; D003764:Dental Materials