title: History and future of growth hormone research.
abstract: The understanding of the mechanisms of growth hormone (GH) action has seen great accomplishments over the last two decades. These achievements include the cloning of a variety of GH and GH receptor (GHR) genes and cDNAs; solving of the three-dimensional structure of GH and the GH/GHR complex, and the discovery of GH antagonists. These GH antagonists have resulted in a new class of drugs with important clinical implications. Animal models in which the GH/insulin-like growth factor (IGF)-I axis has been perturbed also have resulted in many novel findings. We have now entered the era of genomics and proteomics. Genes and proteins that are up- or downregulated as a function of GH action (or lack thereof) will add to the repertoire of knowledge that will lead to a better understanding of the molecular basis of GH action.
authors.affiliation: Edison Biotechnology Institute and Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701, USA. kopchick@ohio.edu
authors.forename: John J
authors.initials: JJ
authors.lastname: Kopchick
mesh_terms: D000818:Animals; D023281:Genomics; D013006:Growth Hormone / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D019382:Human Growth Hormone / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D008958:Models, Molecular; D040901:Proteomics; D011986:Receptors, Somatotropin / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D011986:Receptors, Somatotropin; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone