Leukemia associated clonal expansion of TCR Vbeta subfamily T cells.
The analysis of the T cell receptor (TCR) Vbeta repertoire is one of the most sensitive methods to identify the clonal expansion T cells which respond to tumor associated antigens. Recently, studies have focused on clonally expanded T cells from patients or normal donors induced by leukemia associated antigens in vivo or in vitro. Understanding such clonality and restricted usage of TCR Vbeta repertoire of leukemia-associated expanded T cells may be useful for the design of new immuno-therapeutic strategy for leukemia.
Li
Yangqiu
Y
Institute of Hematology, Medical College, Jinan University, Guangzhou 510632, China. yangquili@hotmail.com
D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics* / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D016693:Receptors, Antigen, T-Cell, alpha-beta