Total syntheses of variolin B and deoxyvariolin B.
Two alternative synthetic routes have been developed for the preparation of variolin B and deoxyvariolin B. The strategy is based on the preparation of the core tricyclic ring common to all variolins, pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine, followed by a palladium-catalyzed cross-coupling reaction to give the tetracyclic system.
Ahaidar
Abderaouf
A
Barcelona Biomedical Research Institute, Barcelona Scientific Park, University of Barcelona, Josep Samitier 1-5, E 08028 Barcelona, Spain.
Fernández
David
D
Danelón
Gerardo
G
Cuevas
Carmen
C
Manzanares
Ignacio
I
Albericio
Fernando
F
Joule
John A
JA
Alvarez
Mercedes
M
D000470:Alkaloids / Q000138:chemical synthesis; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D010165:Palladium / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*
D000470:Alkaloids; D001372:Aza Compounds; D011743:Pyrimidines; C474921:variolin B; D010165:Palladium