Meta-analysis of randomized clinical trials on the usefulness of acetylcysteine for prevention of contrast nephropathy.
Multiple small studies of oral N-acetylcysteine for prevention of contrast nephropathy have been performed, demonstrating variable efficacy. We performed a meta-analysis of the randomized clinical trials to clarify the degree of benefit.
Isenbarger
Daniel W
DW
Cardiovascular Service, Walter Reed Army Medical Center, Washington, DC, USA. daniel.isenbarger@na.amedd.army.mil
Kent
Steven M
SM
O'Malley
Patrick G
PG
D000111:Acetylcysteine / Q000627:therapeutic use*; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000517:prevention & control*; D000975:Antioxidants / Q000627:therapeutic use*; D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D006801:Humans; D016032:Randomized Controlled Trials as Topic
D000975:Antioxidants; D003287:Contrast Media; D003404:Creatinine; D000111:Acetylcysteine