Functional genomics in rodent models of hypertension.
Inbred strains of rodents have been used to study mammalian physiology and pathophysiology in an attempt to understand the contribution of genes in the pathogenesis of the disease process. In this review we focus on experimental animal models to identify quantitative trait loci (QTL) and possible strategies for identifying underlying genetic determinants responsible for hypertension. Confirmation of the existence of the QTL and dissection of the implicated region can be undertaken by production of either recombinant inbred, consomic or congenic strains. Despite complex interactions and the relatively few confirmed causative genes underlying QTL, recent developments in rat genome resources and advancement in statistical and bioinformatic methods will facilitate the identification of major gene(s) responsible for complex, polygenic traits.
McBride
Martin W
MW
BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Glasgow G11 6NT, UK.
Charchar
Fadi J
FJ
Graham
Delyth
D
Miller
William H
WH
Strahorn
Pamela
P
Carr
Fiona J
FJ
Dominiczak
Anna F
AF
D000818:Animals; D004195:Disease Models, Animal; D023281:Genomics / Q000379:methods*; D006973:Hypertension / Q000235:genetics*; D012377:Rodentia