title: Effects of a combined micronutrient supplementation on maternal biological status and newborn anthropometrics measurements: a randomized double-blind, placebo-controlled trial in apparently healthy pregnant women.
abstract: OBJECTIVE
  To investigate the possible beneficial effects of a micronutrient supplementation to apparently healthy pregnant women on maternal biological status and new born anthropometric characteristics.
  
  
  METHODS
  Departments of Obstetric of the University Hospital of Grenoble (France) and Lyon (France), Laboratoire of Biology of Oxidative Stress, UFR de Pharmacie. Grenoble (France).
  
  
  METHODS
  Double-blind, randomized placebo-controlled intervention trial.
  
  
  METHODS
  A total of 100 apparently healthy pregnant women were recruited at 14+/-2 weeks of gestation to delivery. At the end, they were 65 women to follow out the study.
  
  
  METHODS
  Daily consumption over gestation of a micronutrients supplement or placebo.
  
  
  METHODS
  Plasma micronutrient levels and oxidative stress parameters were measured in mothers at 14 and 38 weeks of gestation. New born's anthropometric characteristics were measured at delivery.
  
  
  RESULTS
  In the supplemented group, folic acid, vitamin C, E, B2, B6 and beta-carotene levels were higher than in the placebo group. Oxidative stress parameters were not different between the groups. Birth weights were increased by 10% and the number of low newborn weights (<2700 g) decreased significantly when the mother received the supplementation. Maternal plasma Zn levels were positively correlated to the newborn heights.
  
  
  CONCLUSIONS
  A regular intake of a micronutrient supplement at nutritional dose may be sufficient to improve micronutrient status of apparently healthy pregnant women and could prevent low birth weight of newborn.
authors.affiliation: LBSO, Faculté de Pharmacie, Université Joseph. Fourier, La Tronche, France.
authors.forename: I
authors.initials: I
authors.lastname: Hininger
authors.forename: M
authors.initials: M
authors.lastname: Favier
authors.forename: J
authors.initials: J
authors.lastname: Arnaud
authors.forename: H
authors.initials: H
authors.lastname: Faure
authors.forename: J M
authors.initials: JM
authors.lastname: Thoulon
authors.forename: E
authors.initials: E
authors.lastname: Hariveau
authors.forename: A
authors.initials: A
authors.lastname: Favier
authors.forename: A M
authors.initials: AM
authors.lastname: Roussel
mesh_terms: D000328:Adult; D000886:Anthropometry; D001724:Birth Weight / Q000187:drug effects*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006304:Health Status; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn / Q000254:growth & development*; D018977:Micronutrients / Q000008:administration & dosage* / Q000097:blood; D009752:Nutritional Status; D018384:Oxidative Stress / Q000187:drug effects; D010919:Placebos; D011247:Pregnancy; D011248:Pregnancy Complications / Q000517:prevention & control; D011256:Pregnancy Outcome; D015032:Zinc / Q000008:administration & dosage / Q000097:blood
chemical_list: D018977:Micronutrients; D010919:Placebos; D015032:Zinc