title: blaVIM-7, an evolutionarily distinct metallo-beta-lactamase gene in a Pseudomonas aeruginosa isolate from the United States.
abstract: As part of the CANCER Antimicrobial Surveillance Program in North America, a Pseudomonas aeruginosa isolate, strain 07-406, was shown to possess a metallo-beta-lactamase, designated VIM-7. bla(VIM-7) is located on a 24-kb plasmid which can be readily transferred into Enterobacteriaceae and other pseudomonads. This is the first report of a mobile metallo-beta-lactamase gene, bla(VIM-7), being detected within the United States.
authors.affiliation: Department of Pathology and Microbiology, University of Bristol, Bristol BS8 1TD, United Kingdom. Mark.Toleman@bristol.ac.uk
authors.forename: Mark A
authors.initials: MA
authors.lastname: Toleman
authors.forename: Kenneth
authors.initials: K
authors.lastname: Rolston
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Jones
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Walsh
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D005260:Female; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D010957:Plasmids / Q000235:genetics; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000201:enzymology* / Q000235:genetics*; D014481:United States; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: C481670:VIM-7 metallo-beta-lactamase; D001618:beta-Lactamases