[Acute fluoroacetamide poisoning with main damage to the heart].
OBJECTIVE
To observe the heart damage in 10 patients with acute fluoroacetamide poisoning.


METHODS
Monitoring serum activities of myocardial enzymes [creatine kinase (CK), asparate aminotransferase (AST), lactate dehydrogenase(LDH) and hydroxybutyrate dehydrogenase(HBDH)] and recording ECG on these 10 patients were performed during the period of their hospitalization. In the mean while, 24 hour dynamic ECG were also recorded and analysed using GP7000L Holter.


RESULTS
(1) Urinary fluorine ion concentrations were increased in 9 patients before therapy and in all these 10 patients during therapeutic period. (2) The activities of serum CK in 2 patients and that of serum HBDH in one patient were increased before therapy. However, the serum activities of one or more than one myocardial enzymes were increased in all these 10 patients during therapeutic period. (3) Four patients had abnormal change of ECG before therapy and 5 patients during therapeutic period. (4) 24 hour dynamic ECG records showed that there were heart electrical alternans in 9 patients. One patient had wandering pacemaker and 6 patients had arythmia.


CONCLUSIONS
Fluoroacetamide may cause obvious heart damage, and also heart electrical alternation.
Lin
Jieming
J
Department of Special Examination, Guangzhou No. 12 Hospital, Guangzhou 510620, China.
Jiang
Chaoqiang
C
Ou
Jianping
J
Xia
Gang
G
D000208:Acute Disease; D000410:Alanine Transaminase / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D004562:Electrocardiography / Q000187:drug effects; D005463:Fluoroacetates / Q000506:poisoning*; D006321:Heart / Q000187:drug effects*; D006801:Humans; D006884:Hydroxybutyrate Dehydrogenase / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood
D005463:Fluoroacetates; C007741:fluoroacetamide; D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase; D000410:Alanine Transaminase; D003402:Creatine Kinase