Increased plasma thioredoxin in patients with acute myocardial infarction.
OBJECTIVE
Thioredoxin is an important biomarker for oxidative stress. We investigated whether thioredoxin levels were elevated in patients with acute myocardial infarction (AMI) and were associated with the results of coronary reperfusion.


METHODS
The present study determined plasma thioredoxin levels in 51 patients with AMI, 30 patients with stable exertional angina (SEA), and 30 patients with chest pain syndrome (CPS). Plasma sampling was performed on admission, at 12 h, 1 week, 2 weeks, and 4 weeks in patients with AMI, and after admission in patients with SEA and CPS.


RESULTS
Plasma thioredoxin levels on admission were higher in patients with AMI than in those with SEA and CPS. Plasma thioredoxin levels in patients with AMI were decreased in 12 h without further change thereafter. However, thioredoxin levels in patients with AMI remained higher than in those with SEA. In multivariate analysis, higher levels of thioredoxin on admission were a risk factor for failure in emergent reperfusion therapy in patients with AMI independent of other factors.


CONCLUSIONS
Plasma thioredoxin levels are elevated in patients with AMI, and higher thioredoxin levels may predict subsequent failed coronary reperfusion therapy in patients with AMI.
Soejima
Hirofumi
H
Department of Cardiovascular Medicine, Kumamoto University School of Medicine, Honjo, Kumamoto, Japan. yuuki@gpo.kumamoto-u.ac.jp
Suefuji
Hisakazu
H
Miyamoto
Shinzo
S
Kajiwaram
Ichiro
I
Kojima
Sunao
S
Hokamaki
Jun
J
Sakamoto
Tomohiro
T
Yoshimura
Michihiro
M
Nakamura
Hajime
H
Yodoi
Junji
J
Ogawa
Hisao
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000787:Angina Pectoris / Q000097:blood / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002637:Chest Pain / Q000097:blood / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D018384:Oxidative Stress; D013879:Thioredoxins / Q000097:blood*
D015415:Biomarkers; D013879:Thioredoxins