title: Cold air analgesia in photodynamic therapy of basal cell carcinomas and Bowen's disease: an effective addition to treatment: a pilot study.
abstract: BACKGROUND
  There is considerable interpatient variability in pain tolerance during and after treatment of skin cancer with photodynamic therapy (PDT). Additionally, erythema and edema are common, with mild crusting and healing over 1 to 2 weeks.
  
  
  OBJECTIVE
  To determine whether concurrent cold air analgesia improves the tolerability of PDT.
  
  
  METHODS
  Twenty-six patients with two similar superficial skin cancers were treated with PDT. One lesion was treated with cold air analgesia and the other without. Patients rated their pain during treatment using the Wong Baker Faces Pain Scale and detailed duration of posttreatment pain. At week 2, the inflammatory response was assessed.
  
  
  RESULTS
  A statistically significant difference in the analgesia group was shown with respect to the mean duration of pain and the level of erythema after the first treatment as well as pain scores during the second treatment.
  
  
  CONCLUSIONS
  Patient acceptance of PDT for treatment of nonmelanoma skin cancer is improved with lessened morbidity assessed with concurrent use of cold air analgesia to the treatment field.
authors.affiliation: Dermatology Specialist Centre, Clayfield, Brisbane, Queensland, Western Australia. johnpagliaro@bigpond.com.au
authors.forename: John
authors.initials: J
authors.lastname: Pagliaro
authors.forename: Tim
authors.initials: T
authors.lastname: Elliott
authors.forename: Max
authors.initials: M
authors.lastname: Bulsara
authors.forename: Camilla
authors.initials: C
authors.lastname: King
authors.forename: Carl
authors.initials: C
authors.lastname: Vinciullo
mesh_terms: D000698:Analgesia; D001913:Bowen's Disease / Q000188:drug therapy*; D002280:Basal Cell Carcinoma / Q000188:drug therapy*; D003080:Cold Temperature; D006801:Humans; D010778:Photochemotherapy / Q000379:methods*; D010865:Pilot Projects; D012878:Skin Neoplasms / Q000188:drug therapy*