Chromosome 7q31 allelic imbalance and somatic mutations of RAY1/ST7 gene in colorectal cancer.
ST7 is a putative tumor suppressor gene on chromosome 7q31. However, the role of ST7 as a tumor suppressor is uncertain as somatic mutations have been difficult to demonstrate. In order to investigate the genetic role of RAY1/ST7 in tumorigenesis, we have screened 135 colorectal cancers for loss of heterozygosity (LOH) at chromosome 7q31. The entire RAY1/ST7 gene, including intron/exon boundaries and alternate 5' and 3' sequences of 15/124 (12%) informative cancers with LOH were characterized. No somatic mutations of the RAY1/ST7 gene were observed. Our results do not support a role for RAY1/ST7 as a colorectal cancer tumor suppressor gene.
Haddad
Riad
R
Department of Surgery, Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Ave, Suite 1225, Toronto, Ont. M5G IX5, Canada.
Vincent
John B
JB
Gryfe
Robert
R
Kim
Hyeja
H
Wen
Joseph
J
Redston
Mark
M
Scherer
Stephen W
SW
Gallinger
Steven
S
D000230:Adenocarcinoma / Q000235:genetics*; D022981:Allelic Imbalance; D002897:Chromosomes, Human, Pair 7; D015179:Colorectal Neoplasms / Q000235:genetics*; D006801:Humans; D009154:Mutation; D011506:Proteins / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*
D011506:Proteins; C412123:ST7 protein, human; D025521:Tumor Suppressor Proteins