title: Factors associated with health-related quality of life in chronic pancreatitis.
abstract: OBJECTIVE
  Chronic pancreatitis may lead to considerable reduction in health-related quality of life, but factors associated with a poor perceived health status have not been investigated.
  
  
  METHODS
  We recruited 265 patients with chronic pancreatitis from a tertiary care gastroenterology clinic. Health-related quality of life was assessed using the Short Form-36 Health Survey. Data were compared with age- and gender-adjusted values from the German general population (6964 adults). Factors associated with poor perceived health status were identified by logistic regression.
  
  
  RESULTS
  All domains of health-related quality of life were reduced in chronic pancreatitis. Decrements were most pronounced in role limitations caused by physical (-25%) and emotional health problems (-15%), and general health perceptions (-19%). Severity of abdominal pain, chronic pancreatic diarrhea, low body weight, and loss of work independently contributed to the physical component score of the Short Form-36 (adjusted R2= 33.8%) and were the factors most closely associated with poor health status perception. The etiology and duration of the disease or changes in pancreatic morphology had no impact on health-related quality of life.
  
  
  CONCLUSIONS
  Patients with chronic pancreatitis experience substantial impairments in health-related quality of life. The severity of chronic pancreatitis-related symptoms is directly associated with patient function and well-being. These data offer further insight into the impact of chronic pancreatitis on patient health status and may serve as the basis for the development of disease-specific instruments, which are needed to measure the effect of therapeutic interventions on patient-derived health outcomes.
authors.affiliation: Department of Medicine I, University of Erlangen-Nuremberg, Ulmenweg 18, 91054 Erlangen, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Wehler
authors.forename: Ralf
authors.initials: R
authors.lastname: Nichterlein
authors.forename: Bernhard
authors.initials: B
authors.lastname: Fischer
authors.forename: Michael
authors.initials: M
authors.lastname: Farnbacher
authors.forename: Udo
authors.initials: U
authors.lastname: Reulbach
authors.forename: Eckhart Georg
authors.initials: EG
authors.lastname: Hahn
authors.forename: Thomas
authors.initials: T
authors.lastname: Schneider
mesh_terms: D000328:Adult; D002908:Chronic Disease; D005260:Female; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000503:physiopathology / Q000523:psychology; D011788:Quality of Life; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires