title: Ultrasonography in the evaluation of renal scarring using DMSA scan as the gold standard.
abstract: Dimercaptosuccinic acid (DMSA) renal scan is presently the technique of choice for assessing renal scars. Recent advances suggest that ultrasonography could replace DMSA scan for this purpose. This paper describes the experience of a tertiary pediatric referral hospital performing ultrasonography and DMSA scans in the assessment of renal scarring. Investigations were conducted 3-6 months after patients presented with urinary tract infection (UTI). Results were extracted from the radiology information system and recorded for analysis. All children with a UTI who had undergone DMSA and ultrasound examination on the same day between January 1995 and December 1999 were included; 930 kidneys were compared. DMSA scan was utilized as the reference method. When used to detect focal renal scarring, ultrasonography had a sensitivity of 5.2%, specificity of 98.3%, a positive predictive value (PPV) of 50% and a negative predictive value (NPV) of 75.8%. When used to detect diffuse renal scarring, ultrasonography had a sensitivity of 47.2%, specificity of 91.8%, PPV of 60.8% and NPV of 86.6%. Our results demonstrate that although ultrasonography has a good specificity for the detection of renal scarring compared with DMSA, it has low sensitivity, PPV and NPV. Ultrasonography cannot be substituted for DMSA scan in the evaluation of focal renal scarring.
authors.affiliation: Department of Radiology, Guy's and St Thomas' NHS Trust, London, UK. jimandima@aol.com
authors.forename: Ima
authors.initials: I
authors.lastname: Moorthy
authors.forename: Deirdre
authors.initials: D
authors.lastname: Wheat
authors.forename: Isky
authors.initials: I
authors.lastname: Gordon
mesh_terms: D002648:Child; D002921:Cicatrix / Q000000981:diagnostic imaging*; D006801:Humans; D007674:Kidney Diseases / Q000000981:diagnostic imaging*; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D004113:Succimer; D014463:Ultrasonography
chemical_list: D004113:Succimer