title: Serum concentrations of perfluorooctanesulfonate and other fluorochemicals in an elderly population from Seattle, Washington.
abstract: Perfluorooctanesulfonyl fluoride (POSF, C8F17SO2F) related-materials have been used as surfactants, paper and packaging treatments, and surface (e.g., carpet, textile, upholstery) protectants. A metabolite, perfluorooctanesulfonate (PFOS, C8F17SO3-), has been identified in the serum and liver of non-occupationally exposed humans and wildlife. Because of its persistence, an important question was whether elderly humans might have higher PFOS concentrations. From a prospective study designed to examine cognitive function in the Seattle (WA) metropolitan area, blood samples were collected from 238 dementia-free subjects (ages 65-96). High-pressure liquid chromatography-electrospray tandem mass spectrometry determined seven fluorochemicals: PFOS; N-ethyl perfluorooctanesulfonamidoacetate; N-methyl perfluorooctanesulfonamidoacetate; perfluorooctanesulfonamidoacetate; perfluorooctanesulfonamide; perfluorooctanoate; and perfluorohexanesulfonate. Serum PFOS concentrations ranged from less than the lower limit of quantitation (3.4 ppb) to 175.0 ppb (geometric mean 31.0 ppb; 95% CI 28.8-33.4). An estimate of the 95% tolerance limit was 84.1 ppb (upper 95% confidence limit 104.0 ppb). Serum PFOS concentrations were slightly lower among the most elderly. There were no significant differences by sex or years residence in Seattle. The distributions of the other fluorochemicals were approximately an order of magnitude lower. Similar to other reported findings of younger adults, the geometric mean serum PFOS concentration in non-occupational adult populations likely approximates 30-40 ppb with 95% of the population's serum PFOS concentrations below 100 ppb.
authors.affiliation: Medical Department, 3M Company, Mail Stop 220-3W-05, St. Paul, MN 55144, USA. gwolsen@mmm.com
authors.forename: Geary W
authors.initials: GW
authors.lastname: Olsen
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Church
authors.forename: Eric B
authors.initials: EB
authors.lastname: Larson
authors.forename: Gerald
authors.initials: G
authors.lastname: van Belle
authors.forename: James K
authors.initials: JK
authors.lastname: Lundberg
authors.forename: Kristen J
authors.initials: KJ
authors.lastname: Hansen
authors.forename: Jean M
authors.initials: JM
authors.lastname: Burris
authors.forename: Jeffrey H
authors.initials: JH
authors.lastname: Mandel
authors.forename: Larry R
authors.initials: LR
authors.lastname: Zobel
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D017738:Alkanesulfonic Acids / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D002947:Cities; D004784:Environmental Monitoring; D005260:Female; D017611:Fluorine Compounds / Q000097:blood*; D005466:Fluorocarbons / Q000097:blood*; D006801:Humans; D008297:Male; D013058:Mass Spectrometry; D012737:Sex Factors; D013501:Surface-Active Agents; D014861:Washington
chemical_list: D017738:Alkanesulfonic Acids; D017611:Fluorine Compounds; D005466:Fluorocarbons; D013501:Surface-Active Agents; C076994:perfluorooctane sulfonic acid