title: Mixed papillary adenocarcinoma and transitional cell carcinoma of the uterine cervix.
abstract: A mixed papillary adenocarcinoma and transitional cell carcinoma (MAcTcc) was discovered in the uterine cervix of a 38-year-old woman. A condylomatous papillary lesion was found in the uterine cervix during a colposcopic study and histopathological examination showed that the tumor was composed of two different neoplastic subtypes. One was an adenocarcinoma (AC) component showing papillary and tubular structure with endocervical and intestinal differentiation; the other was a transitional cell carcinoma (TCC) component showing papillary excrescence mimicking papillary TCC of urothelial origin. To characterize the tumor, an immunohistochemical study of cytokeratins (CK) was performed. The AC component showed immunoreactivities similar to conventional adenocarcinomas: positive immunoreactivity of low-molecular-weight cytokeratins 7, 8 and 19, and negative immunoreactivity of CK20 and high-molecular-weight cytokeratin (34betaE12). The lower epithelial layer of the TCC component showed different immunoreactivity, but the superficial epithelial layer had similar immunohistochemical findings to the AC component. These findings indicate that the TCC component had the cellular character of AC rather than that of TCC or squamous cell carcinomas. This is thought to be the first report of a MAcTcc of the uterine cervix.
authors.affiliation: Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Japan. smurata@yamanashi.ac.jp
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Murata
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Miyata
authors.forename: Koji
authors.initials: K
authors.lastname: Takaishi
authors.forename: Kunio
authors.initials: K
authors.lastname: Mochizuki
authors.forename: Tadao
authors.initials: T
authors.lastname: Nakazawa
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kondo
authors.forename: Nobuki
authors.initials: N
authors.lastname: Nakamura
authors.forename: Ryohei
authors.initials: R
authors.lastname: Katoh
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002295:Carcinoma, Transitional Cell / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D009378:Neoplasms, Multiple Primary; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor