title: Use of a gonadotropin-releasing hormone antagonist for endometrial maturation and synchronization in an ovum recipient.
abstract: OBJECTIVE
  To report the novel use of hMG and the GnRH antagonist for endometrial preparation and synchronization in a woman participating in an ovum donation program who was resistant to endometrial preparation with estrogen replacement.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Tertiary fertility center.
  
  
  METHODS
  The patient had inadequate endometrial maturation, as determined by pelvic ultrasound (thickness of <5 mm), after estrogen replacement. Ovarian hyperstimulation with hMG and a GnRH antagonist resulted in an endometrial thickness of 7.5 mm. Synchronization with a ovum donor resulted in a delivered twin gestation.
  
  
  METHODS
  : Late follicular transvaginal ultrasound.
  
  
  METHODS
  Appropriate endometrial maturation and pregnancy.
  
  
  RESULTS
  Appropriate endometrial maturation.
  
  
  CONCLUSIONS
  For women with inadequate endometrial maturation with simple estrogen replacement, ovarian hyperstimulation with hMG and a GnRH antagonist can yield appropriate endometrial maturation for pregnancy through ovum donation.
authors.affiliation: Bethesda Hospital, Cincinnati, Ohio, USA. hofmannge@aol.com
authors.forename: Glen E
authors.initials: GE
authors.lastname: Hofmann
authors.forename: James P
authors.initials: JP
authors.lastname: Sosnowski
authors.forename: Pradeep
authors.initials: P
authors.lastname: Warikoo
authors.forename: Ann
authors.initials: A
authors.lastname: Bertsche
mesh_terms: D000328:Adult; D004717:Endometrium / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D006801:Humans; D008297:Male; D010062:Ovulation Induction / Q000379:methods*; D010298:Parity; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D007987:Gonadotropin-Releasing Hormone