Cup-ling oskar RNA localization and translational control.
RNA localization and spatially restricted translational control can serve to deploy specific proteins to particular places within a cell. oskar (osk) RNA is a key initiatior of posterior patterning and germ cell specification in Drosophila, and its localization and translation are under elaborate control. In this issue, Wilhelm et al. (2003) show that the protein Cup both promotes osk localization and participates in repressing translation of unlocalized osk.
Lasko
Paul
P
Department of Biology, McGill University, 115 West University Parkway, Montréal, Québec, Canada. Paul.Lasko@mcgill.ca
D000818:Animals; D019070:Cell Lineage / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics*; D005854:Germ Cells / Q000166:cytology / Q000378:metabolism*; D019476:Insect Proteins / Q000235:genetics*; D009865:Oocytes / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D009866:Oogenesis / Q000235:genetics*; D014176:Protein Biosynthesis / Q000235:genetics; D012313:RNA / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics
D029721:Drosophila Proteins; D019476:Insect Proteins; D012097:Repressor Proteins; C105238:cup protein, Drosophila; C091675:osk protein, Drosophila; D012313:RNA