title: [Optimization of sanatorium treatment of patients with essential hypertension stage II by chronotherapy].
abstract: A comprehensive chronodiagnostic examination and treatment were performed in 45 patients with essential hypertension stage II aged 37 to 68 years taking 21-day treatment at sanatorium Osetia. The patients were divided into 2 groups: 20 patients of group 1 received basic antihypertensive treatment (enap, hypothiaside) and sulfurated hydrogen balneotherapy not adjusted to individual biorhythm; 25 patients of group 2 received the same treatment by adjusted to biorhythmic phases of basic cardiovascular indices and chronotype established according to Estberg's questionnaire. Estimation of the rhythms of the integral indices of physiological functions (systolic and diastolic arterial pressure, heart rate, body temperature) and "individual minute" was made within 3 days in 4-h intervals. Hemodynamics was studied before and in the end of the treatment with echocardiography, dopplerechocardiography and rheoencephalography. Positive shifts were registered in both groups: a significant fall in arterial pressure, total peripheral vascular resistance, double product and cardiac performance. Patients of group 2 had greater number of significant rhythms of physiological function parameters, primarily circadian, more frequent recovery of amplitude and phase parametric characteristics, better improvement of cerebral circulation, contractile and diastolic functions of the myocardium, reduction of the required medication doses and 2-fold lowering of side effects rate.
authors.forename: S D
authors.initials: SD
authors.lastname: Beliaev
authors.forename: R M
authors.initials: RM
authors.lastname: Zaslavskaia
authors.forename: L G
authors.initials: LG
authors.lastname: Khetagurova
mesh_terms: D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001452:Balneology; D019454:Chronotherapy; D002940:Circadian Rhythm; D004232:Diuretics; D004452:Echocardiography; D015150:Echocardiography, Doppler; D005260:Female; D006294:Health Resorts; D006439:Hemodynamics; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide