Macrophage infiltration of pancreatic acini and islets in acute Kawasaki disease.
A report of 2 patients who developed diabetes after Kawasaki disease (KD) led us to determine whether macrophages and/or T cells infiltrate acute KD pancreas. Three of 10 acute fatal KD cases had diffuse macrophage infiltration of the pancreas; T cells were not prominent. Affected islets were seen in close proximity to normal islets. These findings may explain the rarity of diabetes after KD.
Miura
Masaru
M
Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA. miura@as.email.ne.jp
Garcia
Francesca
F
Crawford
Susan E
SE
Rowley
Anne H
AH
D000208:Acute Disease; D001707:Biopsy, Needle; D016022:Case-Control Studies; D046508:Culture Techniques; D003920:Diabetes Mellitus / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000276:immunology / Q000473:pathology*; D008264:Macrophages / Q000276:immunology* / Q000473:pathology; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000276:immunology / Q000473:pathology*; D011379:Prognosis; D012016:Reference Values; D012680:Sensitivity and Specificity