Review of the quality monitoring methods used by countries using or implementing universal leukoreduction.
Several countries are implementing or have implemented universal leukoreduction (ULR). Specifications, leukocyte counting, and monitoring methods were essential elements in achieving process confidence and conformance. A review of these protocols is presented. A questionnaire was prepared, agreed, and circulated, and responses were collated. Different specifications have been adopted as well as disparate approaches to leukocyte counting and residual leukocyte monitoring. Parametric, nonparametric, and pass-rate methods of analysis were used. Despite these differences, users were satisfied that the methodologies were providing assurance of component quality.
Beckman
Neil
N
Birmingham Blood Center, National Blood Service, Birmingham, United Kingdom. neil.beckman@nbs.nhs.uk
Sher
Graham
G
Masse
Maurice
M
Richter
Ekkehard
E
Ringwald
Juergen
J
Rebulla
Paolo
P
van der Meer
Pieter
P
Justica
Benvindo
B
Walker
Brian
B
Rowe
Graham
G
D002469:Cell Separation / Q000379:methods*; D005374:Filtration; D005434:Flow Cytometry; D006801:Humans; D007391:International Cooperation; D007958:Leukocyte Count; D011786:Quality Control; D013223:Statistics as Topic; D011795:Surveys and Questionnaires