title: Current therapy of ulcerative colitis in children.
abstract: Ulcerative colitis presents in childhood in 10% of those affected, usually with pancolitis. Important features in management include growth, development and avoidance of treatment toxicity. This review addresses the current treatment options including both the paediatric evidence-based experience and areas where paediatric practice is informed by adult studies. Standard treatments include sulfasalazine or 5-aminosalicylates, corticosteroids, purine derivatives (azathioprine or 6-mercaptopurine) and surgery. Other immunosuppressant therapies and the emerging roles for biological therapies and probiotics are discussed.
authors.affiliation: Division of Infection, Inflammation and Repair, University of Southampton Medical School, South Academic Block (Mailpoint 813), Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK. r.bremner@soton.ac.uk
authors.forename: Alan Ronald
authors.initials: AR
authors.lastname: Bremner
authors.forename: David Mervyn
authors.initials: DM
authors.lastname: Griffiths
authors.forename: Robert Mark
authors.initials: RM
authors.lastname: Beattie
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001781:Blood Component Removal; D002648:Child; D002986:Clinical Trials as Topic; D003093:Colitis, Ulcerative / Q000178:diet therapy / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D004334:Drug Administration Schedule; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007167:Immunotherapy; D019936:Probiotics / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D007166:Immunosuppressive Agents