title: Effects of sevoflurane and isoflurane on the ratio of cerebral blood flow/metabolic rate for oxygen in neurosurgery.
abstract: OBJECTIVE
  To examine the changes in cerebral blood flow (CBF) equivalent (CBF divided by cerebral metabolic rate for oxygen) during craniotomy under isoflurane and sevoflurane anesthesia in patients with intracranial disorders.
  
  
  METHODS
  In 16 neurosurgical patients (8 anesthetized with isoflurane and 8 with sevolflurane), the CBF equivalent was measured while the end-tidal concentration of the selected volatile anesthetic was maintained at 0.5 and 1.0 minimum alveolar concentration (MAC) before surgery, and then 1.0 MAC during surgery, which lasted more than 4 hr.
  
  
  RESULTS
  There was no significant difference in CBF equivalent at 0.5 MAC between isoflurane (20 +/- 4ml blood.ml oxygen) groups. With increasing anesthetic depth from 0.5 to 1.0 MAC, the CBF equivalent significantly (P<0.5) increased in both groups (22 +/- 7 and 21 +/- 5, respectively). At 1.0 MAC during operation, the CBF equivalent with both anesthetics was maintained with minimal fluctuation for 4h. There were no significant differences in the average value of the CBF equivalent during a 4-h period at 1.0 MAC between the isoflurane (23 +/- 5) and the sevoflurane (20 +/- 4) groups.
  
  
  CONCLUSIONS
  Deepening anesthesia from 0.5 to 1.0 MAC was maintained with no difference between the two agents during 4h of neurosurgery.
authors.affiliation: Department of Anesthesia, Yamaguchi Riosai Hospital, Onoda, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kuroda
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: J
authors.initials: J
authors.lastname: Tsuruta
authors.forename: T
authors.initials: T
authors.lastname: Murakawa
authors.forename: Y
authors.initials: Y
authors.lastname: Shiroyama