Analysis of fibril formation of amyloid-beta-protein by stretched exponential function.
Kinetic behavior of aggregation of amyloid-beta-protein (Abeta) is represented by a stretched exponential function, F=A[1-exp(-Bt(n))]. Differences in temperature-dependence of A, B and n are studied for Abeta 1-40 and Abeta 1-42. As the temperature is lowered, parameter A is increased, parameter B is decreased and parameter n is increased in Abeta 1-40, while these parameters are less sensitive to temperature in a more hydrophobic protein Abeta 1-42. ln B is a linear function of n, which is shown by ln B = -6.34n + 3.69.
Shinozaki
Ken-ichi
K
Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
Konakahara
Takeo
T
Okuno
Hiroaki
H
Kodaka
Masato
M
D016229:Amyloid beta-Peptides / Q000737:chemistry*; D001923:Brain Chemistry; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D012997:Solvents; D013696:Temperature
D016229:Amyloid beta-Peptides; D012997:Solvents