Tumor vasculature address book: identification of stage-specific tumor vessel zip codes by phage display.
Using in vivo phage display technology with murine tumorigenesis models, two reports have identified peptide motifs that selectively home to distinct molecular vascular targets in a tumor type- and stage-specific manner (Hoffman et al., 2003 and Joyce et al., 2003 [this issue of Cancer Cell]). By probing the surface-protein repertoire of these unique vascular beds, a pioneering draft of a molecular roadmap to decipher the heterogeneity of the vascular system in the context of carcinogenic progression has been plotted. Analysis of these phage peptides that differentially home to dysplastic or invasive tumor vasculature will lay the foundation for identifying unique functional tumor vascular-specific motifs that could potentially be applied to targeted therapeutic and imaging modalities.
Rafii
Shahin
S
Department of Genetic Medicine, Division of Hematology-Oncology, Cornell University Medical College, New York, NY 10021, USA. srafii@med.cornell.edu
Avecilla
Scott T
ST
Jin
David K
DK
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism*; D007610:Kallikreins / Q000378:metabolism; D051379:Mice; D009363:Neoplasm Proteins / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000235:genetics; D010179:Pancreas / Q000378:metabolism; D019151:Peptide Library; D010455:Peptides / Q000235:genetics / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012867:Skin / Q000378:metabolism
D009363:Neoplasm Proteins; D019151:Peptide Library; D010455:Peptides; D011956:Receptors, Cell Surface; C410801:KLK9 protein, human; D007610:Kallikreins