[Study on effects of Erigeron breviscapus extract on anticoagulation].
OBJECTIVE
To study the effect of Erigeron breviscapus extract on anticoagulation.


METHODS
Coagulation time (CT), prothrombin time (PT), platelet factor III (PF3) and euglobulin lysis time (ELT) have been used to evaluate the anticoagulation activities of Erigeron breviscapus extract.


RESULTS
Erigeron breviscapus extract significantly delayed CT and PT, inhibited the activity of PF3, and decreased ELT.


CONCLUSIONS
Erigeron breviscapus extract plays an role in anticoagulation by inhibiting PF3 and prothrombin V. It can also enhance the activity of fibrimolysis.
Wang
Ying
Y
Huazhong University of Sciences and Technology, Wuhan 430074.
Yang
Xiangliang
X
Liu
Hong
H
Tang
Xiaoqiao
X
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D010977:Platelet Factor 3 / Q000187:drug effects*; D011517:Prothrombin Time; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley
D000925:Anticoagulants; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D010977:Platelet Factor 3