title: BRing it on: new insights into the mechanism of brassinosteroid action.
abstract: Several recent breakthroughs have filled in key details of the brassinosteroid (BR) response. Identification of BAK1, a BRI1 interacting protein, the negative regulator BIN2, as well as direct targets of BIN2, BZR1 and BES1, provide a link between BR perception at the cell surface and regulation of gene expression in the nucleus. Global expression studies further defined the downstream events in this pathway, confirming the role of several factors acting in negative feedback regulation on BR levels. New links to the plant hormone, auxin, were also uncovered.
authors.affiliation: Plant Biology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Nemhauser
authors.forename: Joanne
authors.initials: J
authors.lastname: Chory
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000682:Amyloid / Q000502:physiology; D017360:Arabidopsis / Q000201:enzymology / Q000235:genetics / Q000502:physiology*; D029681:Arabidopsis Proteins / Q000502:physiology*; D004268:DNA-Binding Proteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009687:Nuclear Proteins / Q000502:physiology; D011494:Protein Kinases / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013256:Steroids / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000682:Amyloid; D029681:Arabidopsis Proteins; D004268:DNA-Binding Proteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D013256:Steroids; C456160:BES1 protein, Arabidopsis; C454444:BZR1 protein, Arabidopsis; C120083:ITM2B protein, human; C463660:BAK1 protein, Arabidopsis; C448985:At4g18710 protein, Arabidopsis