Antifungal activity of some deoxyhypusine synthase inhibitors (short communication: plant mycology and crop protection).
Several inhibitors of deoxyhypusine synthase were examined for antifungal activity. All compounds, used at concentrations of 1.0 mM or less, reduced mycelial growth of the oat leaf stripe pathogen Pyrenophora avenae grown on solid media. Four of the compounds completely inhibited fungal growth, 4a doing so at a concentration of only 0.61 mM. Inhibition of fungal growth afforded by some of the compounds was more marked than was reflected by the radial growth measurements.
Mackintosh
Caroline A
CA
Department of Plant Biology, Plant Science Division, The Scottish Agricultural College, Auchincruive, Ayr KA6 5HW, UK.
Walters
Dale R
DR
D000935:Antifungal Agents / Q000494:pharmacology; D001203:Ascomycota / Q000187:drug effects* / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000037:antagonists & inhibitors*
D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D000587:Oxidoreductases Acting on CH-NH Group Donors; C063507:deoxyhypusine synthase