title: Dietary fat and the risk of clinical type 2 diabetes: the European prospective investigation of Cancer-Norfolk study.
abstract: The role of dietary fat in the etiology of type 2 diabetes remains uncertain. The authors investigated the association between dietary fat composition and risk of clinical type 2 diabetes in the European Prospective Investigation of Cancer-Norfolk study and identified food consumption patterns associated with dietary fat composition. Diet was assessed at baseline (1993-1997) using a semiquantitative food frequency questionnaire. From multiple sources of information, 414 incident cases of diabetes were identified among 23,631 men and women aged 40-78 years during 3-7 years of follow-up. The capture-recapture ascertainment level was 99%. The energy-adjusted dietary polyunsaturated:saturated fat ratio was inversely associated with the risk of diabetes (odds ratio (OR) = 0.84 per standard deviation change, 95% confidence interval (CI): 0.75, 0.94). Adjustment for age, sex, family history of diabetes, smoking, physical activity, total fat, protein, and alcohol attenuated the association (OR = 0.88, 95% CI: 0.78, 0.99), and it was no longer statistically significant after including body mass index and the waist:hip ratio (OR = 0.91, 95% CI: 0.81, 1.03). This prospective study showed that an increased dietary polyunsaturated:saturated fat ratio was associated with a reduced risk of diabetes, independent of age, sex, family history of diabetes, and other lifestyle factors.
authors.affiliation: Medical Research Council Epidemiology Unit, Cambridge, United Kingdom.
authors.forename: Anne-Helen
authors.initials: AH
authors.lastname: Harding
authors.forename: Nicholas E
authors.initials: NE
authors.lastname: Day
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Sheila
authors.initials: S
authors.lastname: Bingham
authors.forename: Robert
authors.initials: R
authors.lastname: Luben
authors.forename: Ailsa
authors.initials: A
authors.lastname: Welsh
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Wareham
mesh_terms: D000328:Adult; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology* / Q000209:etiology*; D004032:Diet; D015930:Diet Records; D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D005060:Europe / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011446:Prospective Studies; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D006442:Glycated Hemoglobin