Serine phosphorylation: arming Stat1 against infection.
A powerful weapon is critical to a soldier when battling with a strong enemy. In this issue of Immunity, Varinou et al. suggest that serine phosphorylation of Stat1, an important signal transducer and activator of transcription in interferon (IFN) signaling, is required for Stat1 to fight against a highly pathogenic infection.
Shuai
Ke
K
Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D051379:Mice; D010766:Phosphorylation; D010770:Phosphotransferases / Q000378:metabolism*; D050794:STAT1 Transcription Factor; D012694:Serine / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism*
D004268:DNA-Binding Proteins; D050794:STAT1 Transcription Factor; C494080:Stat1 protein, mouse; D015534:Trans-Activators; D012694:Serine; D010770:Phosphotransferases