Differential effects of progestogens on breast cancer cell lines.
Our in vitro results indicate that not all progestogens act equally on breast cancer cells. Some progestogens (medroxyprogesterone acetate (MPA), norethisterone acetate (NETA) and dienogest) alone or combined with estradiol (E2) stimulate proliferation of breast cancer cells, while others (dihydrodydrogesterone (DHD), the active metabolite of dydrogesterone, tibolone and progesterone (Prog)) alone or combined with estradiol induce apoptosis. Further pharmacological and clinical studies should be initiated to evaluate these findings in vivo.
Franke
Henk R
HR
Department of Obstetrics and Gynaecology, Medisch Spectrum Twente Hospital Group, P.O. Box 50000, 7500 KA Enschede, The Netherlands. hfranke@xs4all.nl
Vermes
Istvan
I
D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D006801:Humans; D009640:Norethindrone / Q000031:analogs & derivatives* / Q000494:pharmacology; D000077563:Norethindrone Acetate; D011374:Progesterone / Q000494:pharmacology; D011372:Progestins / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D003280:Contraceptives, Oral, Synthetic; D011372:Progestins; D011374:Progesterone; D004958:Estradiol; D000077563:Norethindrone Acetate; D009640:Norethindrone