title: Multi-detector row CT of left ventricular function with dedicated analysis software versus MR imaging: initial experience.
abstract: OBJECTIVE
  To determine left ventricular (LV) volumetric and functional parameters from retrospectively electrocardiographically gated multi-detector row computed tomography (CT) by using semiautomated analysis software and to correlate results with those of magnetic resonance (MR) imaging.
  
  
  METHODS
  In 30 patients (mean age, 59.2 years +/- 7.1 [SD]) known to have or suspected of having coronary artery disease, four-channel multi-detector row CT was performed with standard technique, and diastolic and systolic image reconstructions were generated. With commercially available analysis software capable of semiautomated contour detection, end diastolic and end systolic LV volumes were determined from short-axis secondary CT reformations. Steady-state free-precession cine MR images were acquired in short-axis orientation within 48 hours and analyzed by using dedicated software. Bland-Altman analysis was performed to calculate limits of agreement and systematic errors between CT and MR imaging.
  
  
  RESULTS
  Mean end diastolic (138.8 mL +/- 31.9) and end systolic (53.9 mL +/- 21.2) LV volumes as determined with CT correlated well with MR imaging measurements (142.0 mL +/- 32.5 [r = 0.93] and 54.9 mL +/- 22.8 [r = 0.94], respectively [P <.001]). LV ejection fraction (61.6% +/- 10.6 for CT vs 62.3% +/- 10.1 for MR imaging; r = 0.89) and stroke volume (84.6 mL +/- 20.9 for CT vs 86.9 mL +/- 21.5 for MR imaging; r = 0.88) also showed good correlation (P <.001). Bland-Altman analysis showed acceptable limits of agreement (+/-9.8% for ejection fraction) without systematic errors.
  
  
  CONCLUSIONS
  In selected patients, semiautomated analysis software enables LV volumetric and functional analysis based on multi-detector row CT data sets, the results of which correlate well with MR imaging findings.
authors.affiliation: Department of Clinical Radiology, University of Muenster, Albert-Schweitzer-Strasse 33, D-48149 Muenster, Germany. kujuerg@uni-muenster.de
authors.forename: Kai Uwe
authors.initials: KU
authors.lastname: Juergens
authors.forename: Matthias
authors.initials: M
authors.lastname: Grude
authors.forename: David
authors.initials: D
authors.lastname: Maintz
authors.forename: Eva Maria
authors.initials: EM
authors.lastname: Fallenberg
authors.forename: Thomas
authors.initials: T
authors.lastname: Wichter
authors.forename: Walter
authors.initials: W
authors.lastname: Heindel
authors.forename: Roman
authors.initials: R
authors.lastname: Fischbach
mesh_terms: D000368:Aged; D002306:Cardiac Volume / Q000502:physiology*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology; D003971:Diastole / Q000502:physiology; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008432:Mathematical Computing; D008875:Middle Aged; D011857:Radiographic Image Interpretation, Computer-Assisted; D012984:Software; D013223:Statistics as Topic; D013318:Stroke Volume / Q000502:physiology; D013599:Systole / Q000502:physiology; D036542:Tomography, Spiral Computed; D016277:Ventricular Function, Left / Q000502:physiology*