title: Total syntheses of variolin B and deoxyvariolin B.
abstract: Two alternative synthetic routes have been developed for the preparation of variolin B and deoxyvariolin B. The strategy is based on the preparation of the core tricyclic ring common to all variolins, pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine, followed by a palladium-catalyzed cross-coupling reaction to give the tetracyclic system.
authors.affiliation: Barcelona Biomedical Research Institute, Barcelona Scientific Park, University of Barcelona, Josep Samitier 1-5, E 08028 Barcelona, Spain.
authors.forename: Abderaouf
authors.initials: A
authors.lastname: Ahaidar
authors.forename: David
authors.initials: D
authors.lastname: Fernández
authors.forename: Gerardo
authors.initials: G
authors.lastname: Danelón
authors.forename: Carmen
authors.initials: C
authors.lastname: Cuevas
authors.forename: Ignacio
authors.initials: I
authors.lastname: Manzanares
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
authors.forename: John A
authors.initials: JA
authors.lastname: Joule
authors.forename: Mercedes
authors.initials: M
authors.lastname: Alvarez
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D010165:Palladium / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D001372:Aza Compounds; D011743:Pyrimidines; C474921:variolin B; D010165:Palladium