title: Evaluation of the antimicrobial property of Polyalthia longifolia var. pendula: isolation of a lactone as the active antibacterial agent from the ethanol extract of the stem.
abstract: Bioassay guided fractionation of the ethanolic extract of Polyalthia longifolia var. pendula stem, which showed promising antibacterial activity against thirteen Gram-positive and nine Gram-negative organisms, furnished (3S,4R)-3,4,5-trihydroxypentanoic acid-1,4-lactone (1) as the active principle. The structure of (1) was established by UV, IR, mass, 1H and 13C NMR as well as 2D NMR spectral studies and the formation of its acetate (1a). On acetylation activity of (1) was markedly reduced. It is synthetically well known and only recently isolated from two plants, however, its antimicrobial activity was not reported earlier. The extract, fractions and pure compounds did not show any remarkable activity against fungi and Mycobacterium fortuitum, and M. smegmatis.
authors.affiliation: H.E.J. Research Institute of Chemistry, University of Karachi, Karachi-75270, Pakistan. shaheen@khi.comsats.net.pk
authors.forename: Shaheen
authors.initials: S
authors.lastname: Faizi
authors.forename: Najma Rasool
authors.initials: NR
authors.lastname: Mughal
authors.forename: Rashid Ali
authors.initials: RA
authors.lastname: Khan
authors.forename: Shakeel Ahmed
authors.initials: SA
authors.lastname: Khan
authors.forename: Aqeel
authors.initials: A
authors.lastname: Ahmad
authors.forename: Nazia
authors.initials: N
authors.lastname: Bibi
authors.forename: Shaheena Anwar
authors.initials: SA
authors.lastname: Ahmed
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D007783:Lactones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects; D009161:Mycobacterium / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D031044:Polyalthia
chemical_list: D000890:Anti-Infective Agents; D007783:Lactones; D010936:Plant Extracts