title: Chlamydia-infected cells continue to undergo mitosis and resist induction of apoptosis.
abstract: Both anti- and proapoptotic activities have been reported to occur during chlamydial infection. To reconcile the apparent controversy, we compared host cell apoptotic responses to infection with 17 different chlamydial serovars and strains. None of the serovars caused any biologically significant apoptosis in the infected host cells. Host cells in chlamydia-infected cultures can continue to undergo DNA synthesis and mitosis. Chlamydia-infected cells are resistant to apoptosis induction, although the extent of the antiapoptotic ability varied between serovars. These observations have demonstrated that an anti- but not proapoptotic activity is the prevailing event in chlamydia-infected cultures.
authors.affiliation: Department of Microbiology and Immunology. University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
authors.forename: Whitney
authors.initials: W
authors.lastname: Greene
authors.forename: Yangming
authors.initials: Y
authors.lastname: Xiao
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Huang
authors.forename: Grant
authors.initials: G
authors.lastname: McClarty
authors.forename: Guangming
authors.initials: G
authors.lastname: Zhong
mesh_terms: D017209:Apoptosis; D002478:Cells, Cultured; D002689:Chlamydia / Q000145:classification / Q000472:pathogenicity* / Q000502:physiology*; D004247:DNA / Q000096:biosynthesis; D006367:HeLa Cells; D006801:Humans; D008938:Mitosis
chemical_list: D004247:DNA