Functional MRI reveals an interhemispheric dissociation of frontal and temporal language regions in a patient with focal epilepsy.
We report the case of a patient with frontal lobe epilepsy in whom the Wada test failed to lateralize representation of language (fluent speech was observed after amobarbital injection on both the right and left side). Functional magnetic resonance imaging (fMRI) during a lexical processing task revealed an atypical organization of language represented by an interhemispheric dissociation of language regions with a right frontal dominance and a left temporal dominance. Consistent with the fMRI results, the patient's ability to name pictures was not reliably impaired by electrocortical stimulation (ECS) of left frontal cortex. The findings from Wada, fMRI, and ECS were confirmed by a lack of language impairment after left frontal lobectomy for seizures. This case illustrates that fMRI can precisely map cortical language networks in epileptic patients and that fMRI may be used to help interpret laterality results provided by the Wada procedure.
Baciu
M V
MV
Department of Psychology, Pierre Mendes-France University, Grenoble, France.
Watson
J M
JM
McDermott
K B
KB
Wetzel
R D
RD
Attarian
H
H
Moran
C J
CJ
Ojemann
J G
JG
D000328:Adult; D001931:Brain Mapping; D004558:Electric Stimulation / Q000379:methods; D004828:Epilepsies, Partial / Q000473:pathology* / Q000503:physiopathology*; D005625:Frontal Lobe / Q000473:pathology*; D007839:Functional Laterality; D006801:Humans; D007802:Language; D007807:Language Tests; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D013702:Temporal Lobe / Q000473:pathology*