title: [Calibration of a room air gas monitor with certified reference gases].
abstract: Photo-acoustic infrared spectrometry is considered to be the gold standard for on-line measurement of anesthetic waste gas in room air. For maintenance of the precision of the measurements, the manufacturer recommends calibration of the gas monitor monitor every 3-12 months. We investigated whether the use of reference gases with analysis certificate could serve as a feasible alternative to commercial recalibration. We connected a multi-gas monitor type1302 (Bruel & Kjaer, Naerum, Denmark) to compressed air bottles containing reference gases with analysis certificate. Using a T-piece with a flow-meter, we avoided the entry of room air during the calibration phase. Highly purified nitrogen was used for zero calibration. The reference concentrations for desflurane, enflurane, halothane, isoflurane, and sevoflurane ranged from 41.6-51.1 ml/m(3) (ppm) in synthetic air. Since there is an overlap of the infrared absorption spectra of volatile anesthetics with alcohol used in operating rooms, we performed a cross-compensation with iso-propanol (107.0 ppm). A two-point calibration was performed for N(2)O (96.2 and 979.0 ppm), followed by cross-compensation with CO(2). Nafion tubes were used in order to avoid erroneous measurements due to molecular relaxation phenomena. The deviation of the measurement values ranged initially from 0-2.0% and increased to up to 4.9% after 18 months. For N(2)O, the corresponding values were 4.2% and 2.7%, respectively. Thus, our calibration procedure using certified reference gases yielded precise measurements with low deterioration over 18 months. It seems to be advantageous that the precision can be determined whenever deemed necessary. This allows for an individual decision, when the gas monitor needs to be calibrated again. The costs for reference gases and working time as well as logistic aspects such as storage and expiration dates must be individually balanced against the costs for commercial recalibration.
authors.affiliation: Klinik für Anaesthesiologie und Intensivmedizin, Universität Tübingen, Tübingen. wolfgang.krueger@uni-tuebingen.de
authors.forename: W A
authors.initials: WA
authors.lastname: Krueger
authors.forename: M
authors.initials: M
authors.lastname: Trick
authors.forename: T H
authors.initials: TH
authors.lastname: Schroeder
authors.forename: K E
authors.initials: KE
authors.lastname: Unertl
mesh_terms: D019840:2-Propanol / Q000032:analysis; D016902:Air Pollution, Indoor / Q000032:analysis*; D018685:Anesthetics, Inhalation / Q000032:analysis*; D002138:Calibration; D004784:Environmental Monitoring / Q000295:instrumentation* / Q000592:standards; D009584:Nitrogen / Q000032:analysis; D009609:Nitrous Oxide / Q000032:analysis; D016273:Occupational Exposure / Q000032:analysis; D009873:Operating Rooms; D012015:Reference Standards; D013055:Spectrophotometry, Infrared
chemical_list: D018685:Anesthetics, Inhalation; D009609:Nitrous Oxide; D009584:Nitrogen; D019840:2-Propanol