Effect on growth parameters of bone marrow transplantation with a chemotherapy-only conditioning regimen.
BACKGROUND
The increasing use of bone marrow transplantation (BMT) has increased survival among a growing number of children and young adults afflicted by malignant and nonmalignant hematologic disorders. Accordingly, quality of life has emerged as an important issue. Because they are a concern in this group, we assessed growth and development, following chemotherapy-only conditioning regimens.


METHODS
Twelve prepubertal children (8 boys, G(1)P(1) and 4 girls, B(1)P(1)) with a mean age of 6 +/- 2 years (age range: 3.5 to 10 years) before and at 3, 6, 9, and 12 months post-BMT.


RESULTS
Growth velocity at 1 year posttransplant was 10.0 +/- 3.5 cm/y. One year post-BMT, the statistical deviation saturation for growth velocity was 4.31 +/- 4.21. Height standard deviation score was -1.4 +/- 1.2 before and -0.5 +/- 1.3 1 year post-BMT (P <.004). The average weight of our subjects was 20 +/- 6 kg before and 26 +/- 9.5 kg 1 year post-BMT.


CONCLUSIONS
BMT with a chemotherapy-only conditioning regimen not only does not disturb growth in children; it is actually associated with a relative growth spurt afterward.
Khoshniat
M
M
Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, 5th Floor, Doctor Shariati Hospital, North Kargar Avenue, Tehran 14114, Iran. emrc@sina.tums.ac.ir
Ghavamzadeh
A
A
Larijani
B
B
Bahar
B
B
Tabatabaei
O
O
D000365:Age Determination by Skeleton; D001827:Body Height / Q000502:physiology*; D001835:Body Weight / Q000502:physiology*; D016026:Bone Marrow Transplantation / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D005198:Fanconi Syndrome / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006128:Growth / Q000502:physiology*; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology / Q000601:surgery; D008297:Male; D009367:Neoplasm Staging; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology / Q000601:surgery; D013997:Time Factors; D017086:beta-Thalassemia / Q000601:surgery
D019382:Human Growth Hormone