Mandibular reconstruction: a histological and histomorphometric study on the use of autogenous scaffolds, particulate cortico-cancellous bone grafts and platelet rich plasma in goats.
Twenty-eight goats underwent a continuity resection of the mandibular angle. In all goats primary reconstruction was carried out using specially designed pre-shaped osteosynthesis plates and monocortical screws. The original cortical scaffold was used to bridge the defect, filled with an autogenous particulate bone graft in 14 goats, whereas platelet-rich-plasma (PRP) was added in another 14 goats. Both groups were divided in three subgroups that were sacrificed after 3, 6 and 12 weeks. Histological and histomorphometric evaluation revealed that the use of PRP enhanced the bone healing considerably. This effect was statistically significant and particularly visible in the 6 and 12 weeks' groups
Fennis
J P M
JP
Department of Oral & Maxillofacial Surgery, University Medical Centre, University of Nijmegen, The Netherlands. j.fennis@chello.nl
Stoelinga
P J W
PJ
Jansen
J A
JA
D000818:Animals; D001792:Blood Platelets; D001860:Bone Plates; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods / Q000502:physiology*; D005782:Gels / Q000494:pharmacology; D006041:Goats; D008334:Mandible / Q000098:blood supply / Q000601:surgery*; D019647:Oral Surgical Procedures; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D010983:Plateletpheresis; D019651:Plastic Surgery Procedures
D005782:Gels; D010982:Platelet-Derived Growth Factor