High illumination levels potentiate the acoustic startle response in preweanling rats.
Fear potentiation of the acoustic startle response (FPS) by aversive conditioned stimuli does not emerge in rats until Postnatal Day (P)23 (see P. S. Hunt & B. A. Campbell, 1997). However, the present study found that when presented with an unconditioned fear-eliciting stimulus, rats younger than P23 display FPS. Specifically, high illumination levels were found to enhance startle amplitudes in rats aged 18 and 25 days, but not 14 days. Furthermore, the light-enhanced startle observed in P18 rats was prevented by a systemic injection of the noradrenergic beta-receptor antagonist propranolol. These data suggest that conditioned and unconditioned FPS have different ontogenetic trajectories, and thereby provide support for the idea that learned and unlearned fear are subserved by dissociable neural systems.
Weber
Marianne
M
School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.
Watts
Nicola
N
Richardson
Rick
R
D000161:Acoustic Stimulation; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000367:Age Factors; D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects / Q000528:radiation effects*; D005071:Evoked Potentials / Q000187:drug effects / Q000528:radiation effects; D005239:Fear / Q000187:drug effects / Q000528:radiation effects*; D005260:Female; D008027:Light; D008029:Lighting; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013216:Reflex, Startle / Q000187:drug effects / Q000528:radiation effects*
D000319:Adrenergic beta-Antagonists; D011433:Propranolol