High levels of myocardial antioxidant defense in aging nondiabetic normotensive Zucker obese rats.
Chronic renal failure often induces left ventricular hypertrophy. We assessed whether the heart is affected in the Zucker obese rat, a model of chronic renal failure associated with obesity, glucose intolerance, and insulin resistance without hypertension or hyperglycemia. After systemic blood pressure measurement, the heart, the aorta, and the kidneys were removed from anesthetized 9- and 13-mo-old Zucker obese and lean control male rats (n = 33, n = 24, n = 25, and n = 21, respectively). Determination of left ventricular geometry, quantification of myocardium collagen density, and measurement of heart antioxidant enzyme activity were made, as well as aorta and kidney parameters. Mean blood pressure remained at a normal range whatever the age and group considered. Whereas kidney structure and function were severely impaired, no sign of myocardial infarction or inflammatory process was noticed. A moderate left ventricular hypertrophy was observed in 13-mo-old obese rats. While heart malondialdehyde was stable with age and among groups, antioxidant enzyme activity was higher in obese rats. In conclusion, in the absence of hypertensive or hyperglycemic disorders, the heat seems to display a sufficient line of defense against oxidative stress during the development of cardiac hypertrophy.
Conti
Marc
M
Bicêtre Hospital, Le Kremlin-Bicêtre, France.
Renaud
Isabelle M
IM
Poirier
Bruno
B
Michel
Odile
O
Belair
Marie-France
MF
Mandet
Chantal
C
Bruneval
Patrick
P
Myara
Isaac
I
Chevalier
Jacques
J
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D003094:Collagen / Q000378:metabolism; D003331:Coronary Vessels / Q000473:pathology; D005978:Glutathione / Q000378:metabolism; D006352:Heart Ventricles / Q000473:pathology; D006439:Hemodynamics / Q000502:physiology; D007150:Immunohistochemistry; D007677:Kidney Function Tests; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009765:Obesity / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D009929:Organ Size / Q000502:physiology; D018384:Oxidative Stress / Q000502:physiology; D051381:Rats; D011924:Rats, Zucker
D000975:Antioxidants; D001786:Blood Glucose; D008315:Malondialdehyde; D003094:Collagen; D005978:Glutathione