title: Acute leukemia in pregnancy with ovarian metastasis: a case report and review of the literature.
abstract: Acute leukemias tend to affect a younger population and are much more common in pregnant patients than chronic leukemias are. We report a case of acute lymphoblastic leukemia diagnosed during the third trimester presenting with organomegaly and thrombocytopenia. Delivery of the fetus by cesarean section was decided because of the fulminant nature of the acute leukemia within days of admission. Bone marrow biopsy revealed acute lymphocytic leukemia, French American-British L2 subtype B cell immunotype. A left ovarian mass was identified during the cesarean section which later proved to be lymphoblastic infiltration. The patient was started on induction chemotherapy consisting of vincristine, daunorubicin, prednisolone, and l-asparaginase immediately after the diagnosis. The patient died of Acinetobacter septicemia 18 days after the first admission.
authors.affiliation: Department of Obstetrics and Gynecology, Ege University Faculty of Medicine, Izmir, Turkey. terek@med.ege.edu.tr
authors.forename: M C
authors.initials: MC
authors.lastname: Terek
authors.forename: E
authors.initials: E
authors.lastname: Ozkinay
authors.forename: O
authors.initials: O
authors.lastname: Zekioglu
authors.forename: Y
authors.initials: Y
authors.lastname: Erhan
authors.forename: S
authors.initials: S
authors.lastname: Cagirgan
authors.forename: M
authors.initials: M
authors.lastname: Pehlivan
authors.forename: L
authors.initials: L
authors.lastname: Mgoyi
mesh_terms: D000151:Acinetobacter Infections / Q000150:complications / Q000209:etiology; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001215:Asparaginase / Q000008:administration & dosage; D002585:Cesarean Section; D003630:Daunorubicin / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000556:secondary*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000473:pathology*; D011239:Prednisolone / Q000008:administration & dosage; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy* / Q000473:pathology*; D018805:Sepsis / Q000209:etiology; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D011239:Prednisolone; D001215:Asparaginase; D003630:Daunorubicin