Development and selection of T cells: how many subsets? How many rules?
Since the discovery indicating that thymus-derived lymphocytes (T cells) can be divided into two subpopulations: CD8+ (killer) and CD4+ (helper) cells, subsequent studies revealed a bewildering heterogeneity of T cells. In the present review an attempt is made to present the current picture of T cell heterogeneity, introduce some order into the nomenclature, and summarize the rules behind the development and selection of different currently recognized T cell subsets.
Kisielow
Paweł
P
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland. kisielow@iitd.pan.wroc.pl
D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000378:metabolism; D016176:T-Lymphocyte Subsets; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology / Q000502:physiology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
D011948:Receptors, Antigen, T-Cell