Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones.
A convenient and efficient palladium-catalysed retro-ene-assisted method has been developed to prepare a series of 5-substituted-6-phenyl-3(2H)-pyridazinones as potential antiplatelet drugs. The most active compounds were those that contain a 3-phenyl-3-oxo-propenyl fragment or a phenylthio group at position 5 of the heterocyclic ring.
Coelho
Alberto
A
Departamento de Qui;mica Orgánica, Laboratorio de Qui;mica Farmacéutica, Drug Research & Development Group, Universidade de Santiago de Compostela, 15782-, Santiago de Compostela, Spain.
Sotelo
Eddy
E
Fraiz
Nuria
N
Yáñez
Matilde
M
Laguna
Reyes
R
Cano
Ernesto
E
Raviña
Enrique
E
D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology*
D010975:Platelet Aggregation Inhibitors; D011724:Pyridazines