Behavioral phenotype of the reeler mutant mouse: effects of RELN gene dosage and social isolation.
Reeler (rl/rl) and reeler/wild-type (+/rl) mice synthesize Reln at subnormal rates, as do patients with schizophrenia, bipolar disorder, and autism, thereby forming the basis for a Reln hypothesis for vulnerability to these psychopathologies and justifying attention to the behavioral phenotypes of Reln-deficient mice. Tests of gait, emotionality, social aggression, spatial working memory, novel-object detection, fear conditioning, and sensorimotor reflex modulation revealed the behavioral phenotype of rl/rl, but not +/rl, mice to be different from that of wild-type (+/+) mice. These results reveal no effect of Reln gene dosage and provide significant challenges to both the Reln and the neurodevelopmental hypotheses of the etiology of major psychopathologies.
Salinger
Walter L
WL
Department of Psychology, University of North Carolina at Greensboro, 27402-6170, USA. salinger@uncg.edu
Ladrow
Pamela
P
Wheeler
Catherine
C
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D003071:Cognition / Q000502:physiology; D004644:Emotions / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005260:Female; D005684:Gait / Q000235:genetics*; D006579:Heterozygote; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000235:genetics*; D009419:Nerve Tissue Proteins; D010641:Phenotype; D000091042:Reelin Protein; D013216:Reflex, Startle / Q000235:genetics*; D012697:Serine Endopeptidases; D012934:Social Isolation
D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; C000717128:Reln protein, mouse; D012697:Serine Endopeptidases