title: Characterization of psu dic(6;5)(p21.3;q13) with reverse chromosome painting in a patient with secondary myelodysplastic syndrome following treatment for multiple myeloma.
abstract: We report a case of a psu dic(6;5)(p21.3;q13) in a patient with secondary myelodysplastic syndrome (sMDS) following treatment for multiple myeloma. The abnormal chromosome was isolated by flow karyotyping and initially identified by reverse chromosome painting. The findings were then confirmed by forward painting. The value of flow karyotyping as a diagnostic technique in hematologic malignancies is discussed.
authors.affiliation: Tumour Molecular Genetics Group, Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK. Lee-JonesL@Cardigff.ac.uk
authors.forename: Lisa
authors.initials: L
authors.lastname: Lee-Jones
authors.forename: Bernard
authors.initials: B
authors.lastname: Ramsahoye
authors.forename: Margaret
authors.initials: M
authors.lastname: Booth
authors.forename: Peter
authors.initials: P
authors.lastname: Thompson
authors.forename: Jack
authors.initials: J
authors.lastname: Whittaker
authors.forename: Terry
authors.initials: T
authors.lastname: Hoy
mesh_terms: D002869:Chromosome Aberrations; D020223:Chromosome Painting / Q000379:methods*; D002895:Chromosomes, Human, Pair 5; D002896:Chromosomes, Human, Pair 6; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000628:therapy*; D009190:Myelodysplastic Syndromes / Q000235:genetics*