title: A three-dimensional breast software phantom for mammography simulation.
abstract: This paper presents a methodology for three-dimensional (3D) computer modelling of the breast, using a combination of 3D geometrical primitives and voxel matrices that can be further subjected to simulated x-ray imaging, to produce synthetic mammograms. The breast phantom is a composite model of the breast and includes the breast surface, the duct system and terminal ductal lobular units. Cooper's ligaments, the pectoral muscle, the 3D mammographic background and breast abnormalities. A second analytical x-ray matter interaction modelling module is used to generate synthetic images from monoenergetic fan beams. Mammographic images of various synthesized breast models differing in size, shape and composition were produced. A preliminary qualitative assessment performed by three radiologists and a quantitative evaluation study using fractal and grey-level histogram analysis were conducted. A comparative study of extracted features with published data has also been performed. The evaluation results indicated good correlation of characteristics between synthetic and actual radiographs. Applications foreseen are not only in the area of breast imaging experimentation but also in education and training.
authors.affiliation: Department of Medical Physics, School of Medicine, University of Patras, 26500, Rio, Patras, Greece. nipa@bme.med.upatras.gr
authors.forename: K
authors.initials: K
authors.lastname: Bliznakova
authors.forename: Z
authors.initials: Z
authors.lastname: Bliznakov
authors.forename: V
authors.initials: V
authors.lastname: Bravou
authors.forename: Z
authors.initials: Z
authors.lastname: Kolitsi
authors.forename: N
authors.initials: N
authors.lastname: Pallikarakis
mesh_terms: D001940:Breast / Q000033:anatomy & histology*; D005260:Female; D006801:Humans; D008327:Mammography / Q000295:instrumentation; D008432:Mathematical Computing; D008953:Models, Anatomic; D019047:Phantoms, Imaging; D011857:Radiographic Image Interpretation, Computer-Assisted; D012984:Software