Oxidative stress in type 1 diabetes.
We have been investigating the effects of preventing oxidative stress on pathogenesis and complications of type 1 diabetes in the NOD mouse model. Our studies have shown that damage caused by oxidative stress is higher in islets and vascular tissue of NOD mice than in nonautoimmune controls or a diabetes-resistant NOD mouse. In addition, phagocytic function and cytokine production by macrophages are aberrant in the NOD. We have demonstrated that treatment of prediabetic NOD mice for 2 weeks with a metalloporphyrin superoxide dismutase (SOD) mimetic results in marked reduction of oxidative stress in islets and vascular tissue and a reversal of macrophage defects.
Haskins
Kathryn
K
Department of Immunology, University of Colorado Health Sciences Center, and National Jewish Medical and Research Center, Denver, Colorado 80206, USA. katie.haskins@uchsc.edu
Bradley
Brenda
B
Powers
Katherine
K
Fadok
Valerie
V
Flores
Sonia
S
Ling
Xiaofeng
X
Pugazhenthi
Subbiah
S
Reusch
Jane
J
Kench
Jennifer
J
D000818:Animals; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000378:metabolism*; D003925:Diabetic Angiopathies / Q000517:prevention & control; D005260:Female; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D016688:Mice, Inbred NOD; D018716:Molecular Mimicry; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000737:chemistry / Q000494:pharmacology
D017362:Cyclic AMP Response Element-Binding Protein; D013482:Superoxide Dismutase