IL-6 modulates hyperglycemia-induced changes of Na+ channel Beta-3 subunit expression by Schwann cells.
Our data show the suppressive effect of hyperglycemia on expression of voltage-gated Na+ channel beta3 subunit by Schwann cells as well as the protection of beta3 expression by treatment with IL-6. Our findings have direct relevance for therapy of diabetic neuropathy.
Skundric
Dusanka S
DS
Department of Neurology, Division of Neuroimmunology, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USA. skundric@cmb.biosci.wayne.edu
Dai
Rujuan
R
Mataverde
Philip
P
D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D017931:DNA Primers; D003929:Diabetic Neuropathies / Q000503:physiopathology; D006943:Hyperglycemia / Q000378:metabolism*; D015850:Interleukin-6 / Q000502:physiology*; D016133:Polymerase Chain Reaction; D051381:Rats; D012583:Schwann Cells / Q000378:metabolism*; D015222:Sodium Channels / Q000378:metabolism*
D017931:DNA Primers; D015850:Interleukin-6; D015222:Sodium Channels