[The relationship between hemoglobin adducts of trinitrotoluene and exposed level].
OBJECTIVE
To explore the biomarkers for monitoring trinitrotoluene (TNT) exposure, the relationship between TNT hemoglobin adducts and TNT exposed level.


METHODS
Hemoglobin adducts (4A-Hb and 2A-Hb) were determined by GC-MS in 25 TNT exposed workers. TNT exposed level was evaluated by determining skin contaminated and inhaled TNT levels. The correlation between hemoglobin adducts level and TNT exposed level was analyzed.


RESULTS
There was a correlation between total TNT exposure level, especially skin exposure level, and 4A-Hb or 2A-Hb content. No significant difference was found between the slopes and intercepts of lin ear equation of (4A-Hb) vs TNT exposed level and linear equation of (4A-Hb +2A-Hb) vs TNT exposed level (P > 0.05).


CONCLUSIONS
Skin contamination is the major role of TNT exposure. TNT exposed level can be evaluated by determining the content of both 4A-Hb and 2A-Hb, and 4A-Hb is more suitable for monitoring TNT exposure.
Song
Wenjia
W
Institute of Occupational Health, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Wang
Yawen
Y
Yan
Huifang
H
Leng
Shuguang
S
Gu
Yeping
Y
Liu
Yuying
Y
Zheng
Yuxin
Y
D004784:Environmental Monitoring / Q000379:methods*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D016273:Occupational Exposure; D012867:Skin / Q000187:drug effects; D014303:Trinitrotoluene / Q000378:metabolism*
D006454:Hemoglobins; D014303:Trinitrotoluene