Lung protective mechanical ventilation in acute respiratory distress syndrome.
The evidence supports the idea that mechanical ventilation can potentially cause further lung injury. The only ventilator manipulation that so far has been shown definitively to reduce injury and improve mortality is the reduction of VT to 6 mL/kg PBW or lower and targeting Pplat to 30 cm H2O or lower. Much research is needed to provide further guidance in applying ventilatory support techniques.
Haas
Carl F
CF
University Hospital Respiratory Care, Critical Care Support Services, University of Michigan Hospitals and Health Centers, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA. chaas@umich.edu
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D055370:Lung Injury; D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D012121:Respiration, Artificial / Q000009:adverse effects* / Q000379:methods; D012128:Respiratory Distress Syndrome / Q000628:therapy*; D013990:Tidal Volume; D015300:Ventilator Weaning