title: [Successful radiotherapy for the thoracic cord infiltration of adult T-cell leukemia/lymphoma].
abstract: A-51-year-old woman with a sixteen-year history of mixed connective tissue disease was admitted to the Kitasato University Hospital because of hypogastric pain in September 1999. Colonofiberscopy and computed tomography in the abdomen demonstrated thickening of the intestinal wall with a hemorrhagic ulcer in the terminal ileum. The histopathologic findings of the lesion revealed diffuse infiltration of atypical T-lymphocytes. The titers of anti-HTLV-I antibody and serum soluble IL-2 receptor were elevated. The diagnosis of adult T-cell leukemia/lymphoma (ATLL) infiltrating the terminal ileum was made. Combination chemotherapy including VEPA-M was undertaken, and resulted in a partial response. ATLL became refractory about June 2000. Flaccid paralysis, dysesthesia in the left lower limb and bladder-bowel disturbance emerged in a few days, July 2000. T2-weighed MRCT images demonstrated that a lesion with a high intensity signal was present in the spinal cord around Th 7. Flower-like cells were detected in the cerebrospinal fluid. Infiltration of ATLL into the thoracic cord was diagnosed. Administration of intrathecal methotrexate and prednisolone, systemic dexamethasone and local irradiation of 30 Gy improved the paralysis and the abnormal MRCT findings. Rehabilitation restored the patient's ability to walk.
authors.affiliation: Department of Internal Medicine IV, Section of Hematology, School of Medicine, Kitasato University.
authors.forename: Nobu
authors.initials: N
authors.lastname: Akiyama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ohtake
authors.forename: Akira
authors.initials: A
authors.lastname: Ohwada
authors.forename: Kohichi
authors.initials: K
authors.lastname: Kajiwara
authors.forename: Miyuki
authors.initials: M
authors.lastname: Hayama
authors.forename: Mika
authors.initials: M
authors.lastname: Kohri
authors.forename: Miyako
authors.initials: M
authors.lastname: Taira
authors.forename: Nozomi
authors.initials: N
authors.lastname: Niitsu
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Horie
authors.forename: Masaaki
authors.initials: M
authors.lastname: Higashihara
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000473:pathology / Q000532:radiotherapy*; D017254:Leukemic Infiltration / Q000532:radiotherapy*; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D013116:Spinal Cord / Q000473:pathology; D013120:Spinal Cord Neoplasms / Q000532:radiotherapy*; D013909:Thorax
chemical_list: D003907:Dexamethasone; D011239:Prednisolone; D008727:Methotrexate