Inhibitors of CTP biosynthesis potentiate the anti-human immunodeficiency virus type 1 activity of 3TC in activated peripheral blood mononuclear cells.
Unlike hydroxyurea, the CTP synthetase inhibitor acivicin and, to a lesser extent, two other inhibitors of CTP synthesis, increased the phosphorylation and anti-HIV-1 activity of 3TC in PHA-P-activated PBMC. These data suggest that to improve the antiretroviral activity of 3TC, it may be worth focusing on inhibition of CTP synthesis.
Dereuddre-Bosquet
Nathalie
N
SPI-BIO c/o Service de Neurovirologie, CEA, 92265, Fontenay-aux-Roses, France.
Roy
Béatrice
B
Routledge
Kate
K
Clayette
Pascal
P
Foucault
Georges
G
Lepoivre
Michel
M
D019380:Anti-HIV Agents / Q000494:pharmacology*; D000963:Antimetabolites / Q000494:pharmacology; D003845:Deoxycytosine Nucleotides / Q000096:biosynthesis / Q000378:metabolism; D004357:Drug Synergism; D015497:HIV-1 / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D007555:Isoxazoles / Q000494:pharmacology*; D019259:Lamivudine / Q000378:metabolism / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000821:virology*; D010835:Phytohemagglutinins / Q000378:metabolism; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D000963:Antimetabolites; D003845:Deoxycytosine Nucleotides; D007555:Isoxazoles; D010835:Phytohemagglutinins; C028784:phytohemagglutinin-P; C024107:2'-deoxycytidine 5'-triphosphate; D019259:Lamivudine; C006303:acivicin