Septal infusions of glucose or pyruvate with muscimol impair spontaneous alternation.
This experiment examined the effects of co-infusing the GABA agonist muscimol (0.5 nmol) with 33 nmol of glucose, pyruvate, fructose or sorbitol into the medial septum on spontaneous alternation. Only co-infusions of muscimol with glucose or pyruvate impaired spontaneous alternation performance; none of the other infusions had any significant effects. The findings suggest that glucose metabolism rather than hyperosmolarity is involved in the memory-impairing interaction between glucose and muscimol.
Shah
Akeel A
AA
Department of Psychology, University of Alberta, Edmonton, AB, Canada.
Parent
Marise B
MB
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D005632:Fructose / Q000008:administration & dosage / Q000494:pharmacology; D018755:GABA Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D009118:Muscimol / Q000008:administration & dosage / Q000494:pharmacology; D019289:Pyruvic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012686:Septal Nuclei / Q000187:drug effects* / Q000502:physiology; D013012:Sorbitol / Q000008:administration & dosage / Q000494:pharmacology
D018755:GABA Agonists; D009118:Muscimol; D005632:Fructose; D013012:Sorbitol; D019289:Pyruvic Acid; D005947:Glucose