Colistin for Klebsiella pneumoniae-associated sepsis.
Klebsiella pneumoniae that was resistant to all available antibiotics (minimum inhibitory concentration of imipenem, 32 microg/mL), including carbapenems, was isolated from blood samples obtained from a 48-year-old patient in the intensive care unit. The patient developed septic shock, which was successfully treated with colistin, the only antibiotic with activity against this multidrug-resistant strain.
Karabinis
A
A
Intensive Care Unit, General Hospital of Athens, George Gennimatas, Athens, Greece.
Paramythiotou
E
E
Mylona-Petropoulou
D
D
Kalogeromitros
A
A
Katsarelis
N
N
Kontopidou
F
F
Poularas
I
I
Malamou-Lada
H
H
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003091:Colistin / Q000627:therapeutic use*; D018432:Drug Resistance, Multiple / Q000502:physiology*; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy*; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D018805:Sepsis / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D003091:Colistin