Chemical modification of mammalian cell surfaces.
The mammalian cell surface is a highly heterogeneous chemical environment with proteins, carbohydrates, lipids and composite molecules controlling vital cell functions. Chemical modification of this environment is a challenge due to the complexity of the surface chemistry and the fragility of the cell. Here, we review recent attempts to perform targeted, non-genetically controlled, changes to cell surface chemistry. Potential applications of cell surface engineering are presented.
Kellam
Barrie
B
School of Pharmaceutical Sciences, University of Nottingham, Nottingham, UK NG7 2RD.
De Bank
Paul A
PA
Shakesheff
Kevin M
KM
D000818:Animals; D002240:Carbohydrate Sequence; D002449:Cell Aggregation / Q000187:drug effects / Q000502:physiology; D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism*; D002784:Cholesterol / Q000031:analogs & derivatives / Q000378:metabolism; D006001:Glycoconjugates / Q000378:metabolism; D006031:Glycosylation; D016695:Glycosyltransferases / Q000378:metabolism; D008969:Molecular Sequence Data; D019158:N-Acetylneuraminic Acid / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000378:metabolism; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods
D006001:Glycoconjugates; D011956:Receptors, Cell Surface; D011092:Polyethylene Glycols; D002784:Cholesterol; D016695:Glycosyltransferases; D019158:N-Acetylneuraminic Acid