Anthelminthic and antiallergic activities of Mangifera indica L. stem bark components Vimang and mangiferin.
This study investigated the antiallergic and anthelmintic properties of Vimang (an aqueous extract of Mangifera indica family stem bark) and mangiferin (the major polyphenol present in Vimang) administered orally to mice experimentally infected with the nematode, Trichinella spiralis. Treatment with Vimang or mangiferin (500 or 50 mg per kg body weight per day, respectively) throughout the parasite life cycle led to a significant decline in the number of parasite larvae encysted in the musculature; however, neither treatment was effective against adults in the gut. Treatment with Vimang or mangiferin likewise led to a significant decline in serum levels of specific anti-Trichinella IgE, throughout the parasite life cycle. Finally, oral treatment of rats with Vimang or mangiferin, daily for 50 days, inhibited mast cell degranulation as evaluated by the passive cutaneous anaphylaxis test (sensitization with infected mouse serum with a high IgE titre, then stimulation with the cytosolic fraction of T. spiralis muscle larvae). Since IgE plays a key role in the pathogenesis of allergic diseases, these results suggest that Vimang and mangiferin may be useful in the treatment of diseases of this type.
García
D
D
Laboratorio de Farmacología, Centro de Química Farmacéutica, Havana, Cuba.
Escalante
M
M
Delgado
R
R
Ubeira
F M
FM
Leiro
J
J
D000284:Administration, Oral; D000707:Anaphylaxis / Q000139:chemically induced / Q000517:prevention & control; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000909:Antibodies, Helminth / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D007814:Larva / Q000187:drug effects / Q000276:immunology; D008297:Male; D031022:Mangifera; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D051381:Rats; D017160:Trichinella spiralis / Q000187:drug effects / Q000276:immunology; D014235:Trichinellosis / Q000517:prevention & control*; D044004:Xanthones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D000871:Anthelmintics; D018926:Anti-Allergic Agents; D000909:Antibodies, Helminth; D010936:Plant Extracts; D044004:Xanthones; C013592:mangiferin