[Study on the correlation of the biochemical indexes in flouride workers].
OBJECTIVE
To explore the correlation among some biochemical indexes in the fluoride workers.


METHODS
The activities of superoxide dismutase(SOD), glutathione peroxidase (GSH-Px), catalase (CAT), alkaline phosphatase (AKP) and the level of calcitonin (CT), parathyroid hormone (PTH), IgG, IgA, IgM, Cu2+, Zn2+, Ca2+, Mg2+ and Se2+, F- in serum and in urine were measured in fifty male fluoride workers and fifty controls.


RESULTS
The levels of F-, CT, PTH, AKP and GSH-Px in serum and F- in urine in exposed group were significantly different from that in control group. Correlation analysis indicated that F- in urine and CAT(r = 0.3133, P < 0.05), CT and PTH(r = 0.5173, P < 0.01), Se2+ and CAT(r = 0.4354, P < 0.05) were positively correlated. There were significantly negative correlation between F- in serum and GSH-Px (r = -0.5202, P < 0.01) and positive correlation among Cu2+, Zn2+, Ca2+ and Mg2+ in serum.


CONCLUSIONS
(1) Excess of fluoride may affect secretion of calcium adjusting hormone (CT, PTH); (2) Changes of AKP and GSH-Px may be regarded as health monitoring indexes; (3) The correlation of biochemical indexes plays an important role in studying the mechanism and the early prevention and treatment of industrial fluorosis.
Huang
Zhijun
Z
Henan Institute of Occupational Disease, Zhengzhou 450052, China.
Li
Kejun
K
Hou
Gang
G
Shen
Zhenhe
Z
Wang
Cui
C
Jiang
Kaiyou
K
Luo
Xiaofang
X
D000469:Alkaline Phosphatase / Q000032:analysis; D002116:Calcitonin / Q000032:analysis; D002374:Catalase / Q000032:analysis; D004784:Environmental Monitoring; D005459:Fluorides / Q000633:toxicity*; D005979:Glutathione Peroxidase / Q000032:analysis; D006801:Humans; D008297:Male; D016273:Occupational Exposure; D010281:Parathyroid Hormone / Q000032:analysis; D013482:Superoxide Dismutase / Q000032:analysis
D010281:Parathyroid Hormone; D002116:Calcitonin; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D000469:Alkaline Phosphatase; D005459:Fluorides