title: [Systemic sclerosis: symptomatic treatment].
abstract: Systemic sclerosis is an autoimmune connective tissue disease resulting in a fibrosis of skin and internal organs. The pathogenesis is unclear and includes genetic and environmental factors leading to an immune activation, vascular abnormalities, fibroblast proliferation and collagen deposition. The treatment of systemic sclerosis can be based on a model of its pathogenesis. Therapy includes vasoactive drugs, prevention of fibrosis or immunosuppression and symptomatic treatment. In our paper we present the proven remedies and novel therapies of systemic sclerosis--disease extremely difficult to treat because of changes in digestive, pulmonary, cardiovascular, neuromuscular and locomotor's systems.
authors.affiliation: Samodzielna Pracownia Immunodermatologii Katedry i Kliniki Dermatologii i Wenerologii Akademii Medycznej w Łodzi.
authors.forename: Bozena
authors.initials: B
authors.lastname: Dziankowska-Bartkowiak
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Waszczykowska
authors.forename: Kamila
authors.initials: K
authors.lastname: Skretkowicz
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D006801:Humans; D012595:Scleroderma, Systemic / Q000188:drug therapy*; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000893:Anti-Inflammatory Agents; D014665:Vasodilator Agents