title: Functional genomics in rodent models of hypertension.
abstract: Inbred strains of rodents have been used to study mammalian physiology and pathophysiology in an attempt to understand the contribution of genes in the pathogenesis of the disease process. In this review we focus on experimental animal models to identify quantitative trait loci (QTL) and possible strategies for identifying underlying genetic determinants responsible for hypertension. Confirmation of the existence of the QTL and dissection of the implicated region can be undertaken by production of either recombinant inbred, consomic or congenic strains. Despite complex interactions and the relatively few confirmed causative genes underlying QTL, recent developments in rat genome resources and advancement in statistical and bioinformatic methods will facilitate the identification of major gene(s) responsible for complex, polygenic traits.
authors.affiliation: BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Glasgow G11 6NT, UK.
authors.forename: Martin W
authors.initials: MW
authors.lastname: McBride
authors.forename: Fadi J
authors.initials: FJ
authors.lastname: Charchar
authors.forename: Delyth
authors.initials: D
authors.lastname: Graham
authors.forename: William H
authors.initials: WH
authors.lastname: Miller
authors.forename: Pamela
authors.initials: P
authors.lastname: Strahorn
authors.forename: Fiona J
authors.initials: FJ
authors.lastname: Carr
authors.forename: Anna F
authors.initials: AF
authors.lastname: Dominiczak
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D023281:Genomics / Q000379:methods*; D006973:Hypertension / Q000235:genetics*; D012377:Rodentia