title: Amino acids as regulators of gene expression: molecular mechanisms.
abstract: Regulation of gene expression by nutrients in mammals is an important mechanism allowing them to adapt their physiological functions according to the supply of nutrient in the diet. It has been shown recently that amino acids are able to regulate by themselves the expression of numerous genes. CHOP, asparagine synthetase, and IGFBP-1 regulation following AA starvation will be described in this review with special interest in the molecular mechanisms involved.
authors.affiliation: Unité de Nutrition et Métabolisme Protéique, Institut National de la Recherche Agronomique de Theix, 63122 Saint Genès Champanelle, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Jousse
authors.forename: Julien
authors.initials: J
authors.lastname: Averous
authors.forename: Alain
authors.initials: A
authors.lastname: Bruhat
authors.forename: Valérie
authors.initials: V
authors.lastname: Carraro
authors.forename: Sylvie
authors.initials: S
authors.lastname: Mordier
authors.forename: Pierre
authors.initials: P
authors.lastname: Fafournoux
mesh_terms: D051701:Activating Transcription Factor 4; D000596:Amino Acids / Q000494:pharmacology* / Q000502:physiology*; D000818:Animals; D001217:Aspartate-Ammonia Ligase / Q000378:metabolism; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics / Q000378:metabolism; D019587:Dietary Supplements; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism; D013217:Starvation / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism; D051742:Transcription Factor CHOP; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: C497109:ATF4 protein, human; D000596:Amino Acids; D022762:CCAAT-Enhancer-Binding Proteins; C497249:DDIT3 protein, human; D018970:Insulin-Like Growth Factor Binding Protein 1; D014157:Transcription Factors; D051701:Activating Transcription Factor 4; D051742:Transcription Factor CHOP; D001217:Aspartate-Ammonia Ligase