title: DDTC, a metabolite of disulfiram, reduces the stimulating effect on ethanol's locomotor activity in mice.
abstract: To investigate how diethyldithiocarbamate (DDTC) affects the stimulating effect of ethanol on open-field locomotion, mice were pretreated with different doses of DDTC 8 hours prior to ethanol. The effect of DDTC and saline on different ethanol doses was analyzed. DDTC reduces ethanol-induced locomotor activity in a dose-dependent manner, not the spontaneous locomotor activity. Aldehyde dehydrogenase might influence psychopharmacological effects of ethanol.
authors.affiliation: Area de Psicobiología, Departamento de Psicología, Universidad de Jeán, Paraje Las Lagunillas, Spain. descara@ujean.es
authors.forename: Maria Dolores
authors.initials: MD
authors.lastname: Escarabajal
authors.forename: Carlos M G
authors.initials: CM
authors.lastname: Aragon
mesh_terms: D000427:Alcohol Deterrents / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D004221:Disulfiram / Q000493:pharmacokinetics / Q000494:pharmacology*; D004050:Ditiocarb / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*
chemical_list: D000427:Alcohol Deterrents; D002492:Central Nervous System Depressants; D000431:Ethanol; D004050:Ditiocarb; D004221:Disulfiram