CS-088, an angiotensin type 1 receptor antagonist, ameliorated the impaired blood flow in the optic nerve head of rabbits.
The effect of CS-088, an angiotensin type 1 receptor antagonist, on optic nerve head (ONH) circulation was investigated in anesthetized rabbits. ONH blood flow was measured for 3 h using laser Doppler flowmetry. ONH blood flow disturbance was induced by intravenous injection of endothelin-1. Blood flow was decreased by 30%; this decrease was reversed by the injection of CS-088. A single injection of CS-088, however, did not alter the baseline ONH blood flow. It is concluded that CS-088 can have a beneficial effect on disturbed ONH blood flow.
Inoue
Tatsuya
T
Pharmacology and Molecular Biology Research Laboratories, Sankyo Company Limited, Tokyo, Japan. inotat@shina.sankyo.co.jp
Yokoyoma
Tomihisa
T
Koike
Hiroyuki
H
D047228:Angiotensin II Type 1 Receptor Blockers; D000818:Animals; D001775:Blood Circulation / Q000187:drug effects*; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D019332:Endothelin-1 / Q000008:administration & dosage; D007093:Imidazoles / Q000494:pharmacology*; D007275:Injections, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects; D017078:Laser-Doppler Flowmetry; D009898:Optic Disk / Q000098:blood supply*; D011817:Rabbits; D013777:Tetrazoles / Q000494:pharmacology*
D047228:Angiotensin II Type 1 Receptor Blockers; D019332:Endothelin-1; D007093:Imidazoles; D013777:Tetrazoles; C437965:olmesartan