Evidence from brain imaging with fMRI supporting functional specificity of acupoints in humans.
We tested whether the stimulation of acupoints in the same spinal segments could induce different central responses with functional magnetic resonance imaging (fMRI) study. Stimulation of acupoints ST36/SP6 (Zusanli/Sanyinjiao) or GB34/BL57 (Yanglingquan/Chengshan) both activated primary and secondary somatosensory area, insula, ventral thalamus, parietal Brodmann Area 40, temporal lobe, putamen, and cerebellum, while de-activated amygdala. Nevertheless, ST36/SP6 stimulation specifically activated orbital frontal cortex and de-activated hippocampus. Alternatively, stimulation of GB34/BL57 activated dorsal thalamus and inhibited those of primary motor area and premotor cortex. Thus, stimulation of acupoints in the same spinal segments induced distinct though overlapped cerebral response patterns, which indicated the existence of acupoint specificity.
Zhang
Wei-Ting
WT
Neuroscience Research Institute, Peking University, 38 Xue Yuan Rd, Beijing 100083, China.
Jin
Zhen
Z
Luo
Fei
F
Zhang
Lei
L
Zeng
Ya-Wei
YW
Han
Ji-Sheng
JS
D000328:Adult; D000679:Amygdala / Q000502:physiology; D001921:Brain / Q000502:physiology*; D002531:Cerebellum / Q000502:physiology; D015671:Electroacupuncture; D005260:Female; D006801:Humans; D007866:Leg / Q000294:innervation; D008279:Magnetic Resonance Imaging; D008297:Male; D017072:Neostriatum / Q000502:physiology; D010296:Parietal Lobe / Q000502:physiology; D010525:Peripheral Nerves / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology; D020651:Ventral Thalamic Nuclei / Q000502:physiology