Nitric oxide signalling with a special focus on lipid-derived mediators.
The ways in which cells communicate among each other concerns all aspects of biology, from developmental processes to diseases. Nitric oxide (NO) is one of the most remarkable and unusual regulatory molecules. It is a labile free radical gas that is not stored but generated on demand, and has been implicated in an extraordinarily diverse range of physiological and pathophysiological functions. The modulation of cell signalling by free radicals is an emerging area of research that provides insight into the orchestration of cell adaptation to a changing microenvironment. In a multicellular organism this serves to coordinate complex physiological responses, such as inflammation. Cell signalling is also accompanied by rapid remodelling of membrane lipids by activated lipases. The discovery that NO, which does not reversibly interact with membrane receptors like conventional hormones and growth factors, targets enzymes such as phospholipase A2, sphingomyelinases or ceramidases, has stimulated growing interest in the crosstalk between redox and lipid signalling.
Huwiler
Andrea
A
Pharmazentrum Frankfurt, Klinikum der Johann-Wolfgang-Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany.
Pfeilschifter
Josef
J
D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D002450:Cell Communication; D015777:Eicosanoids / Q000378:metabolism; D005609:Free Radicals / Q000737:chemistry; D006162:Guanylate Cyclase / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D050356:Lipid Metabolism; D009569:Nitric Oxide / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology*; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013107:Sphingolipids / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D002352:Carrier Proteins; D015777:Eicosanoids; D005609:Free Radicals; D047908:Intracellular Signaling Peptides and Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D013107:Sphingolipids; D014157:Transcription Factors; C022994:cyclic GMP-binding protein; D009569:Nitric Oxide; D011494:Protein Kinases; D010749:Phosphoprotein Phosphatases; D006162:Guanylate Cyclase