Insulin resistance in latent autoimmune diabetes of adulthood.
Insulin resistance in patients with latent autoimmune diabetes of adulthood (LADA) was determined by homeostasis model assessment (HOMA). LADA was identified by a clinical phenotype of type 2 diabetes with antibodies to GAD65 and/or IA-2/ICA512. All patients were managed with insulin therapy. Insulin resistance in LADA was lower than in antibody-negative type 2 diabetes, higher than in normal humans and in recent-onset type 1 diabetes, and similar to that in long-term type 1 diabetes. Mean values for HOMA varied linearly with mean values for BMI, which accounted for much of the insulin resistance in these forms of diabetes. LADA resembles long-term type 1 diabetes with respect to insulin resistance and BMI, but occurs at an older age.
Behme
M T
MT
Lawson Health Research Institute, Robarts Research Institute, London Health Sciences Centre, and St. Joseph's Health Care, University of Western Ontario, London, Ontario, Canada. mbehme@uwo.ca
Dupre
J
J
Harris
S B
SB
Hramiak
I M
IM
Mahon
J L
JL
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D007333:Insulin Resistance; D007527:Isoenzymes / Q000276:immunology; D008297:Male; D008875:Middle Aged
D001323:Autoantibodies; C096322:ICA512 autoantibody; D007527:Isoenzymes; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2