title: 2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors.
abstract: Structure-activity studies on benzamide 1 obtained from library screening led to the discovery of a novel series of potent and selective glycine transporter type-2 inhibitors.
authors.affiliation: Pharmacopeia, Inc., PO Box 5350, Princeton, NJ 08543-5350, USA. kanho@pharmacorp.com
authors.forename: Koc-Kan
authors.initials: KK
authors.lastname: Ho
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Appell
authors.forename: John J
authors.initials: JJ
authors.lastname: Baldwin
authors.forename: Adolph C
authors.initials: AC
authors.lastname: Bohnstedt
authors.forename: Guizhen
authors.initials: G
authors.lastname: Dong
authors.forename: Tao
authors.initials: T
authors.lastname: Guo
authors.forename: Robert
authors.initials: R
authors.lastname: Horlick
authors.forename: Khondaker R
authors.initials: KR
authors.lastname: Islam
authors.forename: Steven G
authors.initials: SG
authors.lastname: Kultgen
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Masterson
authors.forename: Edward
authors.initials: E
authors.lastname: McDonald
authors.forename: Kirk
authors.initials: K
authors.lastname: McMillan
authors.forename: J Richard
authors.initials: JR
authors.lastname: Morphy
authors.forename: Zoran
authors.initials: Z
authors.lastname: Rankovic
authors.forename: Hardy
authors.initials: H
authors.lastname: Sundaram
authors.forename: Maria
authors.initials: M
authors.lastname: Webb
mesh_terms: D026921:Amino Acid Transport Systems, Neutral / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D001549:Benzamides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D016466:CHO Cells; D006224:Cricetinae; D005998:Glycine / Q000037:antagonists & inhibitors / Q000378:metabolism*; D050487:Glycine Plasma Membrane Transport Proteins; D006801:Humans
chemical_list: D026921:Amino Acid Transport Systems, Neutral; D001549:Benzamides; D050487:Glycine Plasma Membrane Transport Proteins; D005998:Glycine