Ischemic stroke after using over the counter products containing ephedra.
Dietary supplements containing Ephedra used for weight loss and physical performance enhancement such as "herbal ecstasy" are widely available, and it is estimated that at least 1% of the adult population have taken these products. Ephedra products including Ephedra alkaloids such as phenylpropanolamine or other ephedrine compounds are sold under different names such as Metabolife 356, Ripped Fuel, Thermadrene, and Shape-Fast Plus. Over 2 years, five patients with ischemic infarctions associated with use of Ephedra products were evaluated at Indiana University Hospital. Ephedrine, like other sympathomimetic agents, predisposes patients to both ischemic and hemorrhagic strokes. People who take over the counter Ephedra products that claim to boost weight loss, increase energy, or bolster physical performance are at risk of adverse events including ischemic and hemorrhagic strokes.
Chen
Cassandra
C
Department of Neurology, Indiana University School of Medicine, Clinical Building 291, 541 Clinical Drive, Indianapolis, IN 46202, USA.
Biller
Jose
J
Willing
Steven J
SJ
Lopez
Alfredo M
AM
D000328:Adult; D019440:Anti-Obesity Agents / Q000009:adverse effects*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D002544:Cerebral Infarction / Q000139:chemically induced / Q000503:physiopathology; D019587:Dietary Supplements / Q000009:adverse effects; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D029789:Ephedra / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000473:pathology; D004366:Nonprescription Drugs / Q000009:adverse effects*; D004364:Pharmaceutical Preparations; D020521:Stroke / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D016896:Treatment Outcome
D019440:Anti-Obesity Agents; D004366:Nonprescription Drugs; D004364:Pharmaceutical Preparations