title: [Effects of Semen Sojae Preparatum on lipid metabolism in ovariectomized rat].
abstract: OBJECTIVE
  To investigate the antiatherosclerotic effect of Semen Sojae Preparatum (SSP) and its mechanism.
  
  
  METHODS
  48 rats were randomly divided into sham operation group (sham), ovariectomized group (OVX) and three doses of OVX + SSP groups. SSP was given to OVX + SSP groups 2 weeks after ovariectomy. The levels of serum lipids and lipid peroxidation were detected after 12 weeks treatment.
  
  
  RESULTS
  SSP lowered serum oxidized-low density lipoprotein cholesterol (OX-LDL, P < 0.01), triglyceride (TG, P < 0.01) and malondialdehyde (MDA, P < 0.05 or P < 0.01), and enhanced serum high density lipoprotein cholesterol (HDL-c, P < 0.05 or P < 0.01), polipoprotein A I (apo-AI, P < 0.01) and superoxide dismutase (SOD, P < 0.01) activity.
  
  
  CONCLUSIONS
  SSP had effects on regulating lipid and antioxidation. Therefore, it might inhibit atherosclerosis in ovariectomy rats.
authors.affiliation: Traditional Chinese Medicine College, Hebei Medical University, Shijiazhuang 050091.
authors.forename: Xinguo
authors.initials: X
authors.lastname: Wang
authors.forename: Xizhen
authors.initials: X
authors.lastname: Ge
authors.forename: Xia
authors.initials: X
authors.lastname: Bai
authors.forename: Cuimiao
authors.initials: C
authors.lastname: Song
authors.forename: Liying
authors.initials: L
authors.lastname: Niu
authors.forename: Huazhou
authors.initials: H
authors.lastname: Xu
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D010052:Ovariectomy; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013025:Glycine max / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal