title: 3-Amino derivative of beta-cyclodextrin: thermodynamics of copper(II) complexes and exploitation of its enantioselectivity in the separation of amino acid racemates by ligand exchange capillary electrophoresis.
abstract: The systems that the 3-amino derivative of beta-cyclodextrin (CD3NH2) forms with the proton, the copper(II) ion and each of the enantiomers of certain amino acids (alanine, phenylalanine, tyrosine and tryptophan) were investigated. The enantioselectivity shown by the potentiometric measurements carried out on the phenylalanine ternary systems was exploited in capillary electrophoresis by ligand exchange capillary electrophoresis (LECE) to obtain the separation of phenylalanine racemate. The tyrosine racemate was also separated by LECE. The comparison between thermodynamic and capillary electrophoresis (CE) results is discussed, in order to get a better insight into the separation mechanism.
authors.affiliation: Dipartimento di Scienze Chimiche, University of Catania, V.le A. Doria 6, Catania 95125, Italy. ecucinotta@dipchi.unict.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cucinotta
authors.forename: Alessandro
authors.initials: A
authors.lastname: Giuffrida
authors.forename: Diego
authors.initials: D
authors.lastname: La Mendola
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Maccarrone
authors.forename: Antonino
authors.initials: A
authors.lastname: Puglisi
authors.forename: Enrico
authors.initials: E
authors.lastname: Rizzarelli
authors.forename: Graziella
authors.initials: G
authors.lastname: Vecchio
mesh_terms: D000596:Amino Acids / Q000302:isolation & purification*; D003300:Copper / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D019075:Electrophoresis, Capillary; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D011199:Potentiometry; D013237:Stereoisomerism; D013816:Thermodynamics; D047392:beta-Cyclodextrins
chemical_list: D000596:Amino Acids; D003505:Cyclodextrins; D008024:Ligands; D047392:beta-Cyclodextrins; D003300:Copper; C031215:betadex