title: Glycosaminoglycan distribution in cartilage as determined by delayed gadolinium-enhanced MRI of cartilage (dGEMRIC): potential clinical applications.
abstract: OBJECTIVE
  We sought to describe a range of in vivo observations of glycosaminoglycan distribution in knee cartilage using the delayed gadolinium-enhanced MRI of cartilage technique.
  
  
  CONCLUSIONS
  The index of glycosaminoglycan distribution, T1(Gd), can exceed 500 msec (denoting high glycosaminoglycan) or can be less than 300 msec, with focal areas as low as 240 msec. Compartmental differences, as well as focal defects within the knee, were observed in patients who had sustained injuries to the ligaments and menisci of the knee or who had chronic osteoarthritis. Overall, these results suggest the need for further research into the biochemical changes seen during disease progression and the effects of therapeutic interventions.
authors.affiliation: Department of Radiology, Beth Israel Deaconess Medical Center, 4 Blackfan Cir., Rm. 147, Boston, MA 02115, USA.
authors.forename: Ashley
authors.initials: A
authors.lastname: Williams
authors.forename: Amy
authors.initials: A
authors.lastname: Gillis
authors.forename: Charles
authors.initials: C
authors.lastname: McKenzie
authors.forename: Bruce
authors.initials: B
authors.lastname: Po
authors.forename: Leena
authors.initials: L
authors.lastname: Sharma
authors.forename: Lyle
authors.initials: L
authors.lastname: Micheli
authors.forename: Brian
authors.initials: B
authors.lastname: McKeon
authors.forename: Deborah
authors.initials: D
authors.lastname: Burstein
mesh_terms: D000328:Adult; D000368:Aged; D002358:Cartilage, Articular / Q000378:metabolism* / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006025:Glycosaminoglycans / Q000378:metabolism*; D006801:Humans; D007718:Knee Injuries / Q000378:metabolism / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000378:metabolism / Q000473:pathology; D013997:Time Factors
chemical_list: D003287:Contrast Media; D006025:Glycosaminoglycans; D019786:Gadolinium DTPA