title: Relationship between fluoroquinolone use and changes in susceptibility to fluoroquinolones of selected pathogens in 10 United States teaching hospitals, 1991-2000.
abstract: We retrospectively examined the relationship between fluoroquinolone use and the susceptibilities of 11 bacterial pathogens to fluoroquinolones in 10 US teaching hospitals from 1991 through 2000. Statistical significance was determined by 2-way analysis of variance, with the number of isolates tested each year as a weighting factor. The analysis of baseline-to-end point change in the percentage of susceptibility and the slope of the regression line (trend line) for logit percentage of susceptibility showed that the overall percentage of susceptibility to fluoroquinolones decreased significantly during the study period (P<.05) and that change in percentage of susceptibility was significantly related to change in fluoroquinolone use (P<.05). Particularly notable were the decreases in the susceptibilities of Pseudomonas aeruginosa, Proteus mirabilis, and Escherichia coli (decreases of 25.1%, 11.9%, and 6.8%, respectively).
authors.affiliation: William Beaumont Hospital, Royal Oak, Michigan 48073, USA. mzervos@beaumont.edu
authors.forename: Marcus J
authors.initials: MJ
authors.lastname: Zervos
authors.forename: Ellie
authors.initials: E
authors.lastname: Hershberger
authors.forename: David P
authors.initials: DP
authors.lastname: Nicolau
authors.forename: David J
authors.initials: DJ
authors.lastname: Ritchie
authors.forename: Lori K
authors.initials: LK
authors.lastname: Blackner
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Coyle
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Donnelly
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Eckel
authors.forename: Robert H K
authors.initials: RH
authors.lastname: Eng
authors.forename: Alexandra
authors.initials: A
authors.lastname: Hiltz
authors.forename: Arpi G
authors.initials: AG
authors.lastname: Kuyumjian
authors.forename: William
authors.initials: W
authors.lastname: Krebs
authors.forename: Angee
authors.initials: A
authors.lastname: McDaniel
authors.forename: Patricia
authors.initials: P
authors.lastname: Hogan
authors.forename: Teresa J
authors.initials: TJ
authors.lastname: Lubowski
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004363:Drug Utilization; D004926:Escherichia coli / Q000187:drug effects*; D024841:Fluoroquinolones / Q000494:pharmacology*; D006784:Hospitals, Teaching; D006801:Humans; D008826:Microbial Sensitivity Tests; D011513:Proteus mirabilis / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012189:Retrospective Studies; D014481:United States
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones