Protection from infectious bursal disease virus (IBDV)-induced immunosuppression by immunization with a fowlpox recombinant containing IBDV-VP2.
Immunosuppression resulting from infectious bursal disease virus (IBDV) infection has critical health and welfare implications for birds, yet it is incompletely understood and largely overlooked as a measure of vaccine efficacy. The ability of a fowlpoxvirus recombinant (fpIBD1) containing the VP2 protein of IBDV to protect against IBDV-induced immunosuppression was investigated by measuring the convalescent chicken's ability to mount antibody responses to IBDV infection, and to inactivated IBDV and salmonella vaccines. An immunoglobulin (Ig)M response, but no IgG response, occurred after IBDV infection. Uninfected chickens produced a sustained IgM response and some IgG response to inactivated IBDV vaccine, while in previously infected birds only a transient IgM response was detected. A moderate suppression of the response to a commercial salmonella vaccine was evident after IBDV infection, which was largely prevented by immunization with fpIBD1. These results indicate that measurement of immunosuppression could be a useful strategy for assessing the efficacy of vaccines to protect against the consequences of IBDV infection.
Butter
C
C
Division of Immunology and Pathology, Institute for Animal Health, Compton, Newbury, Berkshire, UK. colin.butter@bbsrc.ac.uk
Sturman
T D M
TD
Baaten
B J G
BJ
Davison
T F
TF
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000097:blood; D001428:Bacterial Vaccines; D018175:Birnaviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D002645:Chickens / Q000276:immunology*; D005586:Fowlpox / Q000276:immunology / Q000517:prevention & control; D005587:Fowlpox virus / Q000276:immunology; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000097:blood; D007243:Infectious bursal disease virus / Q000276:immunology*; D011201:Poultry Diseases / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D011897:Random Allocation; D012481:Salmonella Infections, Animal / Q000517:prevention & control; D012477:Salmonella enteritidis / Q000276:immunology; D013047:Specific Pathogen-Free Organisms; D014614:Vaccines, Synthetic; D015678:Viral Structural Proteins / Q000276:immunology; D014765:Viral Vaccines
D000914:Antibodies, Viral; D001428:Bacterial Vaccines; D007075:Immunoglobulin M; C082513:VP2 protein, infectious bursal disease virus; D014614:Vaccines, Synthetic; D015678:Viral Structural Proteins; D014765:Viral Vaccines