The role of pelvic exenteration in the management of recurrent rectal cancer.
BACKGROUND
Use of extirpative surgery in the setting of recurrent rectal cancer is controversial given the poor overall outcome of such patients and the morbidity associated with exenteration.


METHODS
A retrospective review of patients treated for recurrent rectal cancer from 1990 to 2002 was performed.


RESULTS
Twenty-two patients underwent pelvic exenteration. Seventeen underwent potentially curative resection, 5 were for palliation only. There was 1 operative death. Fifteen suffered at least 1 complication; 9 suffered multiple complications. Ten patients required readmission to the hospital. The overall disease-free interval was 11 months. Potentially curative and palliative resections resulted in median survivals of 20.4 and 8.4 months, respectively (P = 0.049).


CONCLUSIONS
While patients may derive oncologic and palliative benefits from exenteration, the price in terms of operative morbidity remains high. Newer measures of operative morbidity are necessary to better appraise the value of this radical approach to recurrent rectal cancer.
Kakuda
James T
JT
City of Hope National Medical Center, Department of General Oncologic Surgery, Duarte, CA 91010, USA.
Lamont
Jeffrey P
JP
Chu
David Z J
DZ
Paz
I Benjamin
IB
D000368:Aged; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D010166:Palliative Care; D010385:Pelvic Exenteration / Q000009:adverse effects / Q000401:mortality; D011183:Postoperative Complications; D012004:Rectal Neoplasms / Q000401:mortality / Q000601:surgery*; D012189:Retrospective Studies; D015996:Survival Rate