Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells.
The aim of this study was to investigate the role of coenzyme Q on the mRNA abundance of PHGPx and the reactive oxygen species (ROS) production in two different cell lines from human prostate, a line of non cancer cells (PNT2) and a line of cancer cells (PC3). Results showed that malignant cells markedly differ in their response to coenzyme Q compared to non-malignant cells, with no changes in PHGPx expression and greater ROS production. Furthermore coenzyme Q supplementation significantly lowered cell growth of the PC3 cancer line without affecting the PNT2. If these results are confirmed with additional experiments, it could represent a novel and interesting approach on the biomedical use of coenzyme Q10 in cancer therapy.
Quiles
J L
JL
Institute of Nutrition and Food Technology, University of Granada, Spain. jlquiles@ugr.es
Farquharson
A J
AJ
Ramírez-Tortosa
M C
MC
Grant
I
I
Milne
L
L
Huertas
J R
JR
Battino
M
M
Mataix
J
J
Wahle
K W J
KW
D002460:Cell Line; D005609:Free Radicals / Q000378:metabolism*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D005979:Glutathione Peroxidase / Q000235:genetics*; D006801:Humans; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D011467:Prostate / Q000187:drug effects / Q000201:enzymology* / Q000648:ultrastructure; D011471:Prostatic Neoplasms / Q000201:enzymology* / Q000473:pathology; D012333:RNA, Messenger / Q000032:analysis; D014407:Tumor Cells, Cultured; D014451:Ubiquinone / Q000494:pharmacology*
D005609:Free Radicals; D012333:RNA, Messenger; D014451:Ubiquinone; D005979:Glutathione Peroxidase