title: [Structure, function and the role of factor XIII in human pathology].
abstract: Modern views on the functioning of coagulation system are constantly replenished with the facts obtained using the newest methods of molecular biology and medicine. The purpose of many components of this system is non-uniform and covers the whole spectrum of biochemical reactions responsible for homeostasis. Current data on one of such components--the factor XIII (fibrin stabilizing factor) are stated. Except for the description of the enzyme structure and functions, information is presented about the methods of its detection, which development has resulted in accumulation of knowledge on the role of fibrin stabilizing factor in bleedings and thrombosis genesis. Data are given on hereditary and acquired deficiency of the factor XIII, as well as on conditions accompanied with the increase of its activity.
authors.affiliation: Altai State Medical University, Central Research Laboratory, Russia, Barnaul.
authors.forename: N V
authors.initials: NV
authors.lastname: Sidor
authors.forename: A P
authors.initials: AP
authors.lastname: Momot
mesh_terms: D001777:Blood Coagulation; D005176:Factor XIII / Q000737:chemistry / Q000502:physiology; D006801:Humans; D013379:Substrate Specificity
chemical_list: D005176:Factor XIII