title: Catalytic enantioselective iodocyclization of gamma-hydroxy-cis-alkenes.
abstract: Enantioselective iodocyclization of gamma-hydroxy-cis-alkenes has been achieved using I2 in the presence of an unprecedented catalyst system generated from (R,R)-t-Bu-salen-Co(II) complex and NCS to produce 2-monosubstituted tetrahydrofurans up to 90% ee. While NCS turned out to be the essential additive, neither (R,R)-salen-Co(II) nor (R,R)-salen-Co(III) by itself is likely to be the active species responsible for the asymmetric intramolecular iodoetherification.
authors.affiliation: Center for Molecular Design and Synthesis, Department of Chemistry, School of Molecular Science (BK21), Korea Advanced Institute of Science and Technology, Daejeon 305-701, Korea.
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Kang
authors.forename: Sung Bae
authors.initials: SB
authors.lastname: Lee
authors.forename: Chul Min
authors.initials: CM
authors.lastname: Park