title: Marchiafava-Bignami disease: magnetic resonance imaging findings in corpus callosum and subcortical white matter.
abstract: A case of Marchiafava-Bignami disease (MBD) is presented using magnetic resonance imaging (MRI). A patient with a long history of alcoholism developed a gait disturbance with involuntary movements at the lower extremities. MRI scans taken at the onset showed no particular abnormalities. He progressed to a coma 10 days later. MRI scans taken 20 days after the onset showed a focal lesion at the genu of the corpus callosum and he was diagnosed as having MBD. In addition, multiple lesions were observed in bilateral frontoparietal subcortical white matter. These lesions demonstrated similar intense MRI signals as the corpus callosum.
authors.affiliation: Department of Neurosurgery, Kyoto Kujo Hospital, Karahashi Rajomoncho 10, Minamiku, Kyoto 601-8453, Japan. bukky@h2.dion.ne.jp
authors.forename: Kentaro
authors.initials: K
authors.lastname: Kawarabuki
authors.forename: Takehiko
authors.initials: T
authors.lastname: Sakakibara
authors.forename: Makoto
authors.initials: M
authors.lastname: Hirai
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yoshioka
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Tarumi
authors.initials: T
authors.lastname: Yamaki
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications; D001921:Brain / Q000473:pathology*; D003337:Corpus Callosum / Q000473:pathology; D020233:Gait Disorders, Neurologic / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male