Increase of spiny I activity in striatum after development of context-dependent sensitization of catalepsy in rats.
In this study, it was investigated whether context-dependent sensitization of catalepsy changes the firing pattern in striatum. Rats were treated with either haloperidol (0.5 mg/kg i.p.) or saline, and tested on catalepsy with a concomitant single-unit measurement of the spiny I activity. Administration of haloperidol caused sensitization of catalepsy as measured on bar and grid. Concurrent within this behavioral change, spike-frequency increased over the course of the testing days in haloperidol-treated rats whereas the spike-frequency remained unchanged in saline-treated animals. Burst-frequency remained unchanged within both treatment groups over the days. In conclusion, sensitization of catalepsy is represented by striatal cellular activity as indicated by increases in spike-frequency of spiny I neurons.
Frank
Stefanie Th
ST
Zoologisches Institut, Neuropharmakologie, University of Tuebingen, Auf der Morgenstelle 28E, D-72076 Tuebingen, Germany. st.frank@uni-tuebingen.de
Schmidt
Werner J
WJ
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology*; D003342:Corpus Striatum / Q000503:physiopathology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004594:Electrophysiology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D018492:Dopamine Antagonists; D006220:Haloperidol