title: [The changes of soluble interleukin-2 receptor in serum and cerebrospinal fluid of patients with delayed encephalopathy after acute carbon monoxide poisoning].
abstract: OBJECTIVE
  To explore the changes of soluble interleukin-2 receptor(sIL-2R) in serum and cerebrospinal fluid (CSF) of patients with delayed encephalopathy after acute carbon monoxide poisoning (DEACMP).
  
  
  METHODS
  There were 31 patients with DEACMP, 32 patients with other encephalopathy and 31 controls in this study. The levels of sIL-2R in serum and CSF were detected by ELISA.
  
  
  RESULTS
  Serum sIL-2R in patients with DEACMP[(329.21 +/- 160.99)U/ml] was significantly higher than that in control[(115.67 +/- 89.58) U/ml, P < 0.05)], but not significantly different from that in the other encephalopathy group[(367.50 +/- 123.14) U/ml, P > 0.05)]. CSF sIL-2R in patients with DEACMP[(54.48 +/- 43.04) U/ml] measured a little before discharge was significantly lower than that in patients with the other encephalopathy[(110.24 +/- 76.56) U/ml, P < 0.05)], but not significantly different from that in the control group[(34.96 +/- 22.70)U/ml, P > 0.05)]. At the pre-discharged period, CSF sIL-2R in patients with DEACMP[(100.26 +/- 93.65) U/ml] was significantly higher than that at the early stage of hospitalization[(52.28 +/- 43.31) U/ml, P < 0.05)]. No significant difference in serum sIL-2R was found between early stage of hospitalization[(338.34 +/- 161.53) U/ml] and pre-discharge [(351.31 +/- 175.93) U/ml, P > 0.05)].
  
  
  CONCLUSIONS
  The occurrence of DEACMP may be related with immunopathological damage. The sIL-2R levels in serum and CSF may give information about the state of immunological function of the patients with DEACMP and may contribute to determining the patient's condition and prognosis.
authors.affiliation: Department of Neurology, Second Affiliated Hospital of Xinxiang Medical College, Xinxiang, Henan 453002, China.
authors.forename: Renjun
authors.initials: R
authors.lastname: Gu
authors.forename: Xiuming
authors.initials: X
authors.lastname: Zhang
authors.forename: Luxian
authors.initials: L
authors.lastname: Lu
authors.forename: Hong
authors.initials: H
authors.lastname: Lu
authors.forename: Jinggui
authors.initials: J
authors.lastname: Song
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Guo
authors.forename: Zhongxing
authors.initials: Z
authors.lastname: Zhang
authors.forename: Maixian
authors.initials: M
authors.lastname: Liu
mesh_terms: D001927:Brain Diseases / Q000134:cerebrospinal fluid / Q000276:immunology*; D002249:Carbon Monoxide Poisoning / Q000134:cerebrospinal fluid / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006760:Hospitalization; D006801:Humans; D015375:Receptors, Interleukin-2 / Q000032:analysis / Q000097:blood*
chemical_list: D015375:Receptors, Interleukin-2