Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice.
Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor.
Ko
Jesang
J
Asan Institute for Life Sciences and Department of Internal Medicine, University of Ulsan College of Medicine, Seoul 138-736, Korea.
Shin
Seung Min
SM
Oh
Young Mi
YM
Lee
Youn Soo
YS
Ryoo
Zae Yoong
ZY
Lee
Young Han
YH
Na
Doe Sun
DS
Kim
Jin Woo
JW
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000235:genetics* / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D015513:Oncogene Proteins / Q000235:genetics*; D011518:Proto-Oncogene Proteins; D015183:Restriction Mapping; D002583:Uterine Cervical Neoplasms / Q000235:genetics
C476732:LETMD1 protein, human; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins