title: Factors determining ICD implantation in drug therapy patients after termination of antiarrythmics versus implantable defibrillators trial.
abstract: Because of a significant survival benefit in the defibrillator arm of the Antiarrhythmics versus Implantable Defibrillator (AVID) Trial, patients in the antiarrhythmic drug (AAD) arm were advised to undergo ICD implantation. Despite this recommendation, ICD implantation in AAD patients was variable, with a large number of patients not undergoing ICD implantation. Patients were grouped by those who had been on AAD < 1 year (n = 111) and those on AAD > 1 year (n = 223). Multiple clinical and socioeconomic factors were evaluated to identify those who might be associated with a decision to implant an ICD. The primary reason for patients not undergoing ICD implantation was collected, as well as reasons for a delayed implantation, occurring later than 3 months from study termination. Of 111 patients on AAD for less than 1 year, 53 received an ICD within 3 months compared to 40/223 patients on AAD for more than 1 year (P < 0.001). Patient refusal was the most common reason to not implant an ICD in patients on drug < 1 year; physician recommendation against implantation was the most common in patients on drug > 1 year. Multivariate analysis showed ICD recipients on AAD < 1 year were more likely to be working and have a history of myocardial infarction (MI), while those on AAD > 1 year were more likely to be working, have a history of MI and ventricular fibrillation, and less likely to have experienced syncope, as compared to those who did not get an ICD. Having private insurance may have played a role in younger patients receiving an ICD.
authors.affiliation: Cardiology Division, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA. klein@hsc.utah.edu
authors.forename: Richard C
authors.initials: RC
authors.lastname: Klein
authors.forename: Eleanor B
authors.initials: EB
authors.lastname: Schron
authors.forename: Ellen Graham
authors.initials: EG
authors.lastname: Renfroe
authors.forename: Al
authors.initials: A
authors.lastname: Hallstrom
authors.forename: Jack
authors.initials: J
authors.lastname: Kron
authors.forename: Celeste
authors.initials: C
authors.lastname: Ocampo
authors.forename: Anna
authors.initials: A
authors.lastname: Leonen
authors.forename: Nicholas
authors.initials: N
authors.lastname: Tullo
mesh_terms: D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D017147:Defibrillators, Implantable; D005260:Female; D006801:Humans; D007348:Insurance, Health / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D017180:Tachycardia, Ventricular / Q000188:drug therapy / Q000628:therapy*; D014693:Ventricular Fibrillation / Q000188:drug therapy / Q000628:therapy*
chemical_list: D000889:Anti-Arrhythmia Agents