Aspermytin A: a new neurotrophic polyketide isolated from a marine-derived fungus of the genus Aspergillus.
A new polyketide, aspermytin A (1), was isolated from a cultured marine fungus, Aspergillus sp., which was separated from the mussel, Mytilus edulis. Its structure was elucidated on the basis of their spectral data, and the absolute configuration of 1 was determined by the CD spectrum. Aspermytin A induced neurite outgrowth in rat pheochromocytoma (PC-12) cells at concentration of 50 microM.
Tsukamoto
Sachiko
S
Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, 920-0934, Kanazawa, Japan. sachiko@p.kanazawa-u.ac.jp
Miura
Shunsuke
S
Yamashita
Yuko
Y
Ohta
Tomihisa
T
D000818:Animals; D001230:Aspergillus / Q000302:isolation & purification*; D049872:Bivalvia; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009414:Nerve Growth Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects / Q000502:physiology; D016716:PC12 Cells; D051381:Rats
D018942:Macrolides; D009414:Nerve Growth Factors