title: Changes in serum levels of hepatocyte growth factor in patients undergoing adult-to-adult living-donor liver transplantation.
abstract: Changes in the serum concentration of hepatocyte growth factor (HGF), a potent mitogen for hepatocytes, were investigated in adult-to-adult living-donor liver transplantation (LDLT) in which liver regeneration is involved. Between August 2000 and November 2002, 15 consecutive adult-to-adult LDLTs were performed using the right lobe graft. The recipients were divided into two groups: acute liver failure (n=6) and chronic liver failure (n=9). In addition, right lobe donors (n=12) were evaluated. Measurement of HGF was performed on preoperative and postoperative days 1, 3, 7, and 14 after LDLT. The pretransplant levels of serum HGF were higher in the acute liver failure group than in the chronic liver failure group (P<0.05). After liver replacement, serum HGF levels normalized rapidly in both groups and remained rather low. Despite vigorous liver regeneration in all groups, serum HGF levels did not change significantly after adult-to-adult LDLT with right lobe graft.
authors.affiliation: Department of Transplantation and Digestive Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. e.eguchi@chir.azg.nl
authors.forename: Susumu
authors.initials: S
authors.lastname: Eguchi
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Yanaga
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Okudaira
authors.forename: Nozomu
authors.initials: N
authors.lastname: Sugiyama
authors.forename: Shungo
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Junichiro
authors.initials: J
authors.lastname: Furui
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanematsu
mesh_terms: D000328:Adult; D017228:Hepatocyte Growth Factor / Q000097:blood*; D006801:Humans; D016031:Liver Transplantation / Q000502:physiology*; D019520:Living Donors / Q000706:statistics & numerical data*; D011184:Postoperative Period; D013997:Time Factors
chemical_list: D017228:Hepatocyte Growth Factor