Resolved hypersensitivity myocarditis after ventricular circulatory assist.
Hypersensitivity myocarditis is known to be a cardiac manifestation of a delayed-type hypersensitivity response caused by drug treatment. In heart transplantation candidates the incidence is elevated. We report the case of a patient with end-stage heart failure who underwent implantation of a left ventricular assist device as a bridge to transplantation. The histologic investigation of the left ventricular specimen obtained during device implantation revealed the diagnosis of a hypersensitivity myocarditis. Ten months later this lesion showed complete reversibility within specimens of the explanted heart, maybe as a result of the termination of inotropic therapy after implantation of the left ventricular assist device.
Grabellus
Florian
F
Institute of Pathology, University of Essen, Essen, Germany. florian.grabellus@medizin.uni-essen.de
Hoffmeier
Andreas
A
Schmitz
Klaus J
KJ
Kandolf
Reinhard
R
Bültmann
Burkhard D
BD
Scheld
Hans H
HH
Baba
Hideo A
HA
D002311:Cardiomyopathy, Dilated / Q000188:drug therapy / Q000601:surgery; D002316:Cardiotonic Agents / Q000009:adverse effects*; D004280:Dobutamine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000150:complications* / Q000473:pathology; D016027:Heart Transplantation; D006353:Heart-Assist Devices; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009205:Myocarditis / Q000209:etiology* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D014850:Waiting Lists
D002316:Cardiotonic Agents; D004280:Dobutamine