title: Nail dystrophy, an unusual presentation of incontinentia pigmenti.
abstract: We describe a 57-year-old woman with a history of nail dystrophy since the age of 11 years. Multiple nail clippings were negative and multiple empirical treatments for presumed onychomycosis were unsuccessful. The patient has a daughter with classical incontinentia pigmenti. Molecular genetic analysis was positive for the NEMO gene deletion on the X chromosome, confirming the diagnosis of incontinentia pigmenti. Nail dystrophy was the sole feature of the disease in our patient.
authors.affiliation: Department of Dermatology, Leicester Royal Infirmary, Leicester LE1 5WW, U.K. nicolas.nicolaou@ntlworld.com
authors.forename: N
authors.initials: N
authors.lastname: Nicolaou
authors.forename: R A C
authors.initials: RA
authors.lastname: Graham-Brown
mesh_terms: D041321:Chromosomes, Human, X; D005260:Female; D017353:Gene Deletion; D006801:Humans; D051550:I-kappa B Kinase; D007184:Incontinentia Pigmenti / Q000150:complications* / Q000235:genetics; D008875:Middle Aged; D009264:Nails, Malformed / Q000209:etiology* / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics
chemical_list: D017346:Protein Serine-Threonine Kinases; C496559:CHUK protein, human; D051550:I-kappa B Kinase; C496560:IKBKB protein, human; C496565:IKBKE protein, human