Paraneoplastic movement disorder in a patient with non-Hodgkin's lymphoma and CRMP-5 autoantibody.
The paraneoplastic autoantibody, collapsin response-mediator protein (CRMP)-5 immunoglobulin G (IgG), is specific for neuronal cytoplasmic CRMP-5, and is usually associated with small-cell lung carcinoma or thymoma. We report on details of a movement disorder that followed anti-B-cell therapy in a patient with lymphoma, and was accompanied by CRMP-5 IgG.
Samii
Ali
A
Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA. asamii@u.washington.edu
Dahlen
Debra D
DD
Spence
Alexander M
AM
Maronian
Nicole C
NC
Kraus
Eric E
EE
Lennon
Vanda A
VA
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000276:immunology*; D001921:Brain / Q000276:immunology / Q000473:pathology; D002819:Chorea / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology*; D004421:Dystonia / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology*; D005260:Female; D006801:Humans; D006867:Hydrolases; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D008279:Magnetic Resonance Imaging; D008869:Microtubule-Associated Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology*; D000069283:Rituximab
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D001323:Autoantibodies; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D000069283:Rituximab; C415087:DPYSL5 protein, human; D006867:Hydrolases