Preparation of a biodegradable matrix through polyion complex formation by mixing polylactide-based microspheres having oppositely charged surfaces.
The aggregation of polyions into microsphere (MS) complexes was studied as a preparative method for the construction of a biodegradable matrix. Aqueous suspensions of polylactide (PLA)-based MSs with positively and negatively charged surfaces, MS(K(3)(4+)-PLA) and MS(E(3)(4-)-PLA), respectively, immediately formed aggregates when mixed. The effects of the stoichiometry of the charged groups on the surfaces of the MSs and the ionic strength of the medium on aggregate formation, as well as the degradation behavior of the polyion complex (PIC) matrix over time, were investigated.
Arimura
Hidetoshi
H
Faculty of Engineering and High Technology Research Center, Kansai University, Suita, 564-8680 Osaka, Japan. gf2d401@ipcku.kansai-u.ac.jp
Ohya
Yuichi
Y
Ouchi
Tatsuro
T
Yamada
Hideaki
H
D000042:Absorption; D001672:Biocompatible Materials; D006868:Hydrolysis; D007477:Ions / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008823:Micelles; D008863:Microspheres; D008956:Models, Chemical; D011091:Polyesters / Q000737:chemistry*; D013997:Time Factors
D001672:Biocompatible Materials; D007477:Ions; D008823:Micelles; D011091:Polyesters; C033616:poly(lactide)