title: A novel t(2;17) in transformation of essential thrombocythemia to acute myelocytic leukemia.
abstract: A transformation of essential thrombocythemia to acute myelocytic leukemia (AML), myelodysplastic syndrome, or agnogenic myelocytic metaplasia is a relatively rare event. It occurs in 1%-4.5% of all patients with either treated or untreated essential thrombocythemia. Cytogenetic changes in the transformation to AML are common. We report the case of a patient treated for essential thrombocythemia with hydroxyurea for 49 months. He developed AML with a t(2;17), which to our knowledge has not been described in the literature.
authors.affiliation: Institute of Hematology, Clinical Center of Serbia, Koste Todorovica 2 Street, Belgrade, Serbia, Yugoslavia. vladimir.lazarevic@vll.se
authors.forename: Vladimir Lj
authors.initials: VLj
authors.lastname: Lazarevic
authors.forename: Dragica
authors.initials: D
authors.lastname: Tomin
authors.forename: Gradimir M
authors.initials: GM
authors.lastname: Jankovic
authors.forename: Darko
authors.initials: D
authors.lastname: Antic
authors.forename: Marija
authors.initials: M
authors.lastname: Dencic
authors.forename: Mirjana
authors.initials: M
authors.lastname: Gotic
authors.forename: Darinka
authors.initials: D
authors.lastname: Boskovic
mesh_terms: D000368:Aged; D002886:Chromosomes, Human, Pair 17; D002889:Chromosomes, Human, Pair 2; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000235:genetics*; D008297:Male; D013920:Thrombocythemia, Essential / Q000150:complications* / Q000188:drug therapy; D014178:Translocation, Genetic