Association between interleukin 1-beta promoter (-511) polymorphism and depressive symptoms in Alzheimer's disease.
Depressive symptoms have been associated with raised interleukin 1-beta (IL-1beta) plasma levels. The presence of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease, including depressive symptoms, have been shown to be influenced by common genetic polymorphisms. A common polymorphism in the promoter region of IL-1beta has been linked to altered synthesis of IL-1beta. We hypothesize that this common genetic polymorphism is a risk factor for the appearance of depressive symptoms in AD. A total of 133 subjects, diagnosed as probable AD and 156 controls were genotyped for the -511 variant of IL-1beta. Neither genotype or allele frequencies differed between the AD and control group. However, an allelic association was found between the T variant and the symptoms of depression in AD subjects. Genotypic analysis showed that heterozygotes were three times more likely to develop depressive symptoms than CC homozygotes.
McCulley
Michelle C
MC
University of Southampton, Human Genetics Division, School of Medicine, Duthie Building (MP808), Southampton General Hospital, Tremona Road, Southampton, United Kingdom.
Day
Ian N M
IN
Holmes
Clive
C
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000150:complications / Q000235:genetics*; D003863:Depression / Q000209:etiology / Q000473:pathology*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*
D007375:Interleukin-1