title: [Study on making pneumoconiosis model and method of lung lavage in rabbit].
abstract: OBJECTIVE
  To provide an intact rabbit pneumoconiosis model and a method of lung lavage for studying the pathogenesis and treatment of pneumoconiosis.
  
  
  METHODS
  The dust particles(< or = 5 microns diameter) were poured into the trachea of rabbit by trachea spile. The lung lavage of rabbit was carried out by the improved trachea catheter method.
  
  
  RESULTS
  The rabbit lungs exposed to coal dust showed many black dust spots and there were proliferation of fibroblasts. The rabbit lungs exposed to silica dust showed nodules and several fusing nodules. The X-ray film showed that there were small irregular shadows, or fusing together into flake-like or round shadows in both lungs. The recovery rate of the lung lavage was 89%-94%.
  
  
  CONCLUSIONS
  The model made by trachea spile and the method of lung lavage by the improved trachea catheter were simple, safe and without being injured.
authors.affiliation: Department of Occupational Health and Toxicology, Zhengzhou University, Zhengzhou, 450052, China.
authors.forename: Dong
authors.initials: D
authors.lastname: Xu
authors.forename: Yiming
authors.initials: Y
authors.lastname: Wu
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Yubao
authors.initials: Y
authors.lastname: Xu
authors.forename: Aimin
authors.initials: A
authors.lastname: Meng
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Zhangxian
authors.initials: Z
authors.lastname: Liu
authors.forename: Ran
authors.initials: R
authors.lastname: Zhu
mesh_terms: D000818:Animals; D018893:Bronchoalveolar Lavage / Q000379:methods*; D003031:Coal; D004195:Disease Models, Animal; D004391:Dust; D008168:Lung / Q000473:pathology; D011009:Pneumoconiosis / Q000209:etiology*; D011817:Rabbits; D012822:Silicon Dioxide
chemical_list: D003031:Coal; D004391:Dust; D012822:Silicon Dioxide