Dysbiosis in inflammatory bowel disease.
Abundant data have incriminated intestinal bacteria in the initiation and amplification stages of inflammatory bowel diseases. However, the precise role of intestinal bacteria remains elusive. One theory has suggested a breakdown in the balance between putative species of "protective" versus "harmful" intestinal bacteria--this concept has been termed "dysbiosis". Arguments in support of this concept are discussed.
Tamboli
C P
CP
Division of Gastroenterology, Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA. cyrus-tamboli@uiowa.edu
Neut
C
C
Desreumaux
P
P
Colombel
J F
JF
D000818:Animals; D001419:Bacteria / Q000302:isolation & purification*; D004195:Disease Models, Animal; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000382:microbiology* / Q000628:therapy; D007422:Intestines / Q000382:microbiology*; D019936:Probiotics / Q000627:therapeutic use