Local and cultural aspects of childhood idiopathic thrombocytopenic purpura: a summary of statements from the 12 countries worldwide.
Idiopathic thrombocytopenic purpura (ITP) is a heterogeneous bleeding disorder. The Intercontinental Childhood ITP Study Group (ICIS) analyzed demographic data and outcome in a prospective registry of over 2,000 children with ITP. In addition, participating centers from 12 different countries worldwide were asked to describe their local and cultural aspects of ITP management to provide a summary statement of the variable diagnostic and management approaches for childhood ITP. The statements of the 15 reports from 12 countries are summarized under eight main areas to reflect the variability in approach to ITP among different countries. The management of ITP in children differs dramatically worldwide in terms of observation only, medical treatment, bleeding symptoms, acceptable platelet counts, need for hospitalization or outpatient treatment, and medical care climate. The majority of experimental treatments, surveys, and guidelines are not evidence-based. Although there is a great need for cooperative studies to learn more about diagnosis, management, and prognosis in the heterogeneous disorder of ITP, local and cultural variations must be considered in international investigations.
Imbach
Paul
P
University Children's Hospital Basel and Intercontinental Childhood ITP Study Group (ICIS), Roemergasse 23, CH-4005 Basel, Switzerland. paul.imbach@unibas.ch
Zimmerman
Sherri
S
D001118:Argentina; D001208:Asia; D001315:Australia; D002170:Canada; D002648:Child; D003431:Cross-Cultural Comparison; D005060:Europe; D019317:Evidence-Based Medicine; D006801:Humans; D020300:Intracranial Hemorrhages / Q000453:epidemiology; D011379:Prognosis; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000503:physiopathology* / Q000628:therapy*; D012307:Risk Factors; D014481:United States