title: Normal bone mineral content in young adults with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.
abstract: OBJECTIVE
  To assess bone mineral content (BMC) and body composition in adolescents and young adults with congenital adrenal hyperplasia.
  
  
  METHODS
  BMC, anteroposterior-projected bone area (BA), bone mineral density, and fat mass percentage were determined by dual-energy X-ray absorptiometry in 18 patients aged 18-33 years (8 females and 10 males) with 21-hydroxylase deficiency using a Hologic QDR 1000/W densitometer.
  
  
  RESULTS
  BMC and bone mineral density for age were significantly reduced at -1.2 standard deviation scores (SDS; range from -2.8 to +4.1) and -1.1 SDS (range from -3.2 to +2.6), respectively. The BA for height was significantly increased at +1.7 SDS (range from -0.5 to +4.8), and the BMC for BA was normal at 0.3 SDS (range from -2.0 to +3.6). The median final height was significantly reduced at -1.6 SDS (range from -5.6 to +0.3), and the fat mass percentage was significantly increased at +1.5 SDS (range from -1.0 to +5.0).
  
  
  CONCLUSIONS
  Our study population of young adults with 21-hydroxylase deficiency had a short stature and broad bones with a normal BMC and had an increased fat mass percentage.
authors.affiliation: Department of Growth and Reproduction, Section GR-5064, Rigshospitalet, Copenhagen, Denmark. pech@glostruphosp.kbhamt.dk
authors.forename: Peter
authors.initials: P
authors.lastname: Christiansen
authors.forename: Christian
authors.initials: C
authors.lastname: Mølgaard
authors.forename: Jørn
authors.initials: J
authors.lastname: Müller
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology; D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000201:enzymology*; D000328:Adult; D001827:Body Height; D001835:Body Weight; D015519:Bone Density / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D013255:Steroid 21-Hydroxylase / Q000378:metabolism*
chemical_list: D013255:Steroid 21-Hydroxylase