Paroxysmal exercise-induced dystonia as a presenting feature of young-onset Parkinson's disease.
Paroxysmal exercise-induced dystonia (PED) is a rare, typically idiopathic familial condition, although sporadic and secondary cases have been reported. We present 2 cases where PED was the presenting feature of young-onset idiopathic Parkinson's disease (PD), preceding the onset of parkinsonian symptoms by 1.5 and 5 years, respectively. Initially, the dystonic symptoms occurred after prolonged exercise and were unilateral, affecting the foot in both patients. Over time, symptoms occurred with minimal exercise. We conclude that PED can rarely be the first and only feature of PD.
Bozi
Maria
M
Sobell Department of Movement Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom.
Bhatia
Kailash P
KP
D000328:Adult; D000367:Age Factors; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001479:Basal Ganglia / Q000378:metabolism; D003937:Diagnosis, Differential; D050483:Dopamine Plasma Membrane Transport Proteins; D004421:Dystonia / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D015444:Exercise; D005149:Facial Expression; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins / Q000172:deficiency; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D010300:Parkinson Disease / Q000175:diagnosis* / Q000188:drug therapy; D011699:Putamen / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon; D014202:Tremor / Q000175:diagnosis; D014282:Trihexyphenidyl / Q000627:therapeutic use
D000978:Antiparkinson Agents; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D014282:Trihexyphenidyl