title: Treatment of pacemaker induced severe mitral regurgitation with biventricular pacing in two patients with a normal left ventricular ejection fraction.
abstract: This report describes two patients who developed severe mitral regurgitation and drug refractory congestive heart failure after implantation of a conventional pacemaker. Both patients had a normal left ventricular ejection fraction. Dramatic long-term improvement occurred following the institution of biventricular pacing that resulted in mild mitral regurgitation. The findings illustrate the benefit of cardiac resynchronization therapy in pacemaker induced left ventricular dyssynchrony causing severe mitral regurgitation and severe congestive heart failure in selected patients with a normal left ventricular ejection fraction.
authors.affiliation: St. Joseph's Hospital, Tampa, Florida, USA. irwinpa@bayheartgroup.com
authors.forename: James M
authors.initials: JM
authors.lastname: Irwin
authors.forename: Matthew U
authors.initials: MU
authors.lastname: Glover
authors.forename: S Serge
authors.initials: SS
authors.lastname: Barold
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D010138:Pacemaker, Artificial / Q000009:adverse effects*; D012720:Severity of Illness Index; D013318:Stroke Volume