Baroreflex control of heart rate during heating in subjects with low orthostatic tolerance.
BACKGROUND
Heat stress induces a reduction of orthostatic tolerance. The cardiovascular responses, including the cardiac baroreflex response to heat stress, were examined to test the hypothesis that subjects with orthostatically low tolerance demonstrate an impaired baroreflex control of heart rate (HR) during heat stress.


METHODS
There were 44 healthy young volunteers who underwent whole body heat stress produced by a hot-water-perfused suit during supine rest for 45 min and 75 degrees head-up tilt (HUT) for 6 min. Esophageal temperature, HR, arterial pressure, and skin blood flow in the forearm and palm were measured continuously throughout the experiment. The sensitivity of the arterial baroreflex control of HR was calculated from the spontaneous changes in beat-to-beat arterial pressure and HR.


RESULTS
The HUT was uneventful for 22 volunteers (higher tolerance group), but 22 volunteers (lower tolerance group) reached presyncope after 195 +/- 19 s. Esophageal temperature, HR, arterial pressure, and skin blood flow changed similarly in the two groups during heating. In the preheating condition, the sensitivity of the baroreflex control of HR did not differ significantly between the two groups. Heating did not alter the sensitivity of baroreflex control of HR in the higher tolerance group, but decreased it significantly in the lower tolerance group. Heating increased the number of heartbeats used for analysis of the baroreflex sensitivity in the higher tolerance group, but did not change it in the lower tolerance group.


CONCLUSIONS
These results suggest that the impairment of vagal baroreflex control of HR during heat exposure aggravates the orthostatic intolerance in heat-stressed humans.
Yamazaki
Fumio
F
Department of Clinical Pathophysiology, School of Health Sciences, University of Occupational and Environmental Health, 807-8555 Kitakyushu, Japan. yamazaki@health.uoeh-u.ac.jp
Kawahara
Chie
C
Soga
Izumi
I
Yamada
Shinwa
S
Hamasaki
Kunshige
K
D000328:Adult; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D018882:Heat Stress Disorders / Q000503:physiopathology*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000503:physiopathology*; D008297:Male; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply; D014630:Vagus Nerve / Q000502:physiology