title: Human protein reference database as a discovery resource for proteomics.
abstract: The rapid pace at which genomic and proteomic data is being generated necessitates the development of tools and resources for managing data that allow integration of information from disparate sources. The Human Protein Reference Database (http://www.hprd.org) is a web-based resource based on open source technologies for protein information about several aspects of human proteins including protein-protein interactions, post-translational modifications, enzyme-substrate relationships and disease associations. This information was derived manually by a critical reading of the published literature by expert biologists and through bioinformatics analyses of the protein sequence. This database will assist in biomedical discoveries by serving as a resource of genomic and proteomic information and providing an integrated view of sequence, structure, function and protein networks in health and disease.
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21287, USA.
authors.forename: Suraj
authors.initials: S
authors.lastname: Peri
authors.forename: J Daniel
authors.initials: JD
authors.lastname: Navarro
authors.forename: Troels Z
authors.initials: TZ
authors.lastname: Kristiansen
authors.forename: Ramars
authors.initials: R
authors.lastname: Amanchy
authors.forename: Vineeth
authors.initials: V
authors.lastname: Surendranath
authors.forename: Babylakshmi
authors.initials: B
authors.lastname: Muthusamy
authors.forename: T K B
authors.initials: TK
authors.lastname: Gandhi
authors.forename: K N
authors.initials: KN
authors.lastname: Chandrika
authors.forename: Nandan
authors.initials: N
authors.lastname: Deshpande
authors.forename: Shubha
authors.initials: S
authors.lastname: Suresh
authors.forename: B P
authors.initials: BP
authors.lastname: Rashmi
authors.forename: K
authors.initials: K
authors.lastname: Shanker
authors.forename: N
authors.initials: N
authors.lastname: Padma
authors.forename: Vidya
authors.initials: V
authors.lastname: Niranjan
authors.forename: H C
authors.initials: HC
authors.lastname: Harsha
authors.forename: Naveen
authors.initials: N
authors.lastname: Talreja
authors.forename: B M
authors.initials: BM
authors.lastname: Vrushabendra
authors.forename: M A
authors.initials: MA
authors.lastname: Ramya
authors.forename: A J
authors.initials: AJ
authors.lastname: Yatish
authors.forename: Mary
authors.initials: M
authors.lastname: Joy
authors.forename: H N
authors.initials: HN
authors.lastname: Shivashankar
authors.forename: M P
authors.initials: MP
authors.lastname: Kavitha
authors.forename: Minal
authors.initials: M
authors.lastname: Menezes
authors.forename: Dipanwita Roy
authors.initials: DR
authors.lastname: Choudhury
authors.forename: Neelanjana
authors.initials: N
authors.lastname: Ghosh
authors.forename: R
authors.initials: R
authors.lastname: Saravana
authors.forename: Sreenath
authors.initials: S
authors.lastname: Chandran
authors.forename: Sujatha
authors.initials: S
authors.lastname: Mohan
authors.forename: Chandra Kiran
authors.initials: CK
authors.lastname: Jonnalagadda
authors.forename: C K
authors.initials: CK
authors.lastname: Prasad
authors.forename: Chandan
authors.initials: C
authors.lastname: Kumar-Sinha
authors.forename: Krishna S
authors.initials: KS
authors.lastname: Deshpande
authors.forename: Akhilesh
authors.initials: A
authors.lastname: Pandey
mesh_terms: D019295:Computational Biology; D030562:Databases, Protein; D004194:Disease; D023281:Genomics; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020543:Proteome / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D040901:Proteomics; D013379:Substrate Specificity; D018875:Vocabulary, Controlled
chemical_list: D011506:Proteins; D020543:Proteome