Primary Rosai-Dorfman disease of bone without lymphadenopathy diagnosed by fine needle aspiration cytology. A case report.
BACKGROUND
Solitary bone involvement without lymphadenopathy is a rare manifestation of Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy (SHML). Only 11 cases have been reported in the literature to date, all diagnosed on histology.


METHODS
A 7-year-old girl had a radiolucent, lytic lesion in the shaft of the tibia clinically simulating Ewing's sarcoma. Fine needle aspiration cytology (FNAC) showed a microscopic picture typical--of SHML. There was no lymphadenopathy.


CONCLUSIONS
Rosai-Dorfman disease sometimes involves bone without lymphadenopathy and can be diagnosed confidently on FNAC. To the best of our knowledge, this is the 12th case report of solitary bone involvement.
Goel
Madhu Mati
MM
Department of Pathology, King George's Medical College, Lucknow, U.P., India.
Agarwal
Padam Kumari
PK
Agarwal
Sanjeev
S
D044963:Biopsy, Fine-Needle; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D002648:Child; D003937:Diagnosis, Differential; D018483:Diaphyses / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006644:Histiocytes / Q000473:pathology*; D015618:Histiocytosis, Sinus / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008206:Lymphatic Diseases / Q000473:pathology; D011859:Radiography; D009418:S100 Proteins / Q000378:metabolism; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology
D009418:S100 Proteins