Benzimidazole drugs and modulation of biotransformation enzymes.
Benzimidazole drugs (e.g., anthelmintics albendazole, fenbendazole, oxfenbendazole, thiabendazole, mebendazole; inhibitors of proton pump omeprazole, lansoprasole, pantoprasole) represent substances used in both human and veterinary medicine; however, from the point of view of induction and inhibition of biotransformation enzymes, research has been carried out mainly due to the initiative of human pharmacologists. The purpose of the present review is to inform about inductive and inhibitive effects of benzimidazole drugs in man, animals and cell cultures. Pharmacological and toxicological consequences of modulation of biotransformation enzymes are discussed and the significance of studies in the field of modulation of biotransformation enzymes in food-producing animals is explained. Since the modulating effect of benzimidazoles strongly varies depending on structure of the individual substances, the particular attention is paid to structure-modulation relationships.
Velík
J
J
Department of Pharmacology and Toxicology, Research Centre LN00B125, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Heyrovského 1203, CZ-500 05, Hradec Králové, Czech Republic. 95vej2299@faf.cuni.cz
Baliharová
V
V
Fink-Gremmels
J
J
Bull
S
S
Lamka
J
J
Skálová
L
L
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D001711:Biotransformation / Q000187:drug effects; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D013329:Structure-Activity Relationship
D001562:Benzimidazoles; D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System