title: Beta-blockers may provoke oxygen desaturation during submaximal exercise at moderate altitudes in elderly persons.
abstract: Frequency of therapeutic beta-blocker use in elderly mountaineers is unknown. Therefore, the aim of this field study was to measure the regular beta-blocker intake in elderly persons visiting moderate altitudes. In a subset of mountaineers on beta-blockers, exercise response at two different altitude levels was compared to matched controls. The observed frequency of beta-blocked persons among the interviewed elderly mountaineers (age >35) was 7%, mainly (65%) due to hypertension. In subjects taking beta-blockers, arterial oxygen saturation (84 +/- 6% vs. 90 +/- 3%, p < 0.05) was decreased and heart rate (120 +/- 17 bpm vs. 112 +/- 14 bpm, p = 0.01), rate pressure product (22,192 +/- 6459 vs. 17,576 +/- 4010, p < 0.05), and ratings of perceived exertion (14 +/- 3 vs. 12 +/- 3, p < 0.05) were increased during a submaximal step test at 2311 m compared to 1480 m. Mountaineers without beta-blocker intake showed no changes. Although the epidemiological data have to be interpreted with caution because of the small sample size and the limitation to a single geographical site, a large number of beta-blocked persons visiting high altitudes was observed. If confirmed in further studies, the increased heart work and exertion could indicate a reduced exercise tolerance of people taking beta-blockers during acute high altitude exposure.
authors.affiliation: Department of Sport Science, Medical Section, University of Innsbruck, Innsbruck, Austria. martin.faulhaber@uibk.ac.at
authors.forename: Martin
authors.initials: M
authors.lastname: Faulhaber
authors.forename: Markus
authors.initials: M
authors.lastname: Flatz
authors.forename: Martin
authors.initials: M
authors.lastname: Burtscher
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects*; D000328:Adult; D000368:Aged; D000532:Altitude Sickness / Q000503:physiopathology*; D001317:Austria; D003324:Coronary Artery Disease / Q000188:drug therapy; D017079:Exercise Tolerance / Q000187:drug effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009051:Mountaineering; D010101:Oxygen Consumption / Q000187:drug effects*; D005082:Physical Exertion / Q000187:drug effects; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000319:Adrenergic beta-Antagonists