title: The Pfam protein families database.
abstract: Pfam is a large collection of protein families and domains. Over the past 2 years the number of families in Pfam has doubled and now stands at 6190 (version 10.0). Methodology improvements for searching the Pfam collection locally as well as via the web are described. Other recent innovations include modelling of discontinuous domains allowing Pfam domain definitions to be closer to those found in structure databases. Pfam is available on the web in the UK (http://www.sanger.ac.uk/Software/Pfam/), the USA (http://pfam.wustl.edu/), France (http://pfam.jouy.inra.fr/) and Sweden (http://Pfam.cgb.ki.se/).
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. agb@sanger.ac.uk
authors.forename: Alex
authors.initials: A
authors.lastname: Bateman
authors.forename: Lachlan
authors.initials: L
authors.lastname: Coin
authors.forename: Richard
authors.initials: R
authors.lastname: Durbin
authors.forename: Robert D
authors.initials: RD
authors.lastname: Finn
authors.forename: Volker
authors.initials: V
authors.lastname: Hollich
authors.forename: Sam
authors.initials: S
authors.lastname: Griffiths-Jones
authors.forename: Ajay
authors.initials: A
authors.lastname: Khanna
authors.forename: Mhairi
authors.initials: M
authors.lastname: Marshall
authors.forename: Simon
authors.initials: S
authors.lastname: Moxon
authors.forename: Erik L L
authors.initials: EL
authors.lastname: Sonnhammer
authors.forename: David J
authors.initials: DJ
authors.lastname: Studholme
authors.forename: Corin
authors.initials: C
authors.lastname: Yeats
authors.forename: Sean R
authors.initials: SR
authors.lastname: Eddy
mesh_terms: D000818:Animals; D019295:Computational Biology; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D008958:Models, Molecular; D005810:Multigene Family; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000145:classification*
chemical_list: D011506:Proteins