The folate receptor as a molecular target for tumor-selective radionuclide delivery.
The cell-membrane folate receptor is a potential molecular target for tumor-selective drug delivery, including radiolabeled folate-chelate conjugates for diagnostic imaging. We review here some background on the folate receptor as tumor-associated molecular target for drug delivery, and briefly survey the literature on tumor-targeting with radiolabeled folate-chelate conjugates.
Ke
Chun-Yen
CY
Department of Industrial and Physical Pharmacy, Purdue University, West, Lafayette, IN 47907-2091, USA.
Mathias
Carla J
CJ
Green
Mark A
MA
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D058973:Folate Receptors, GPI-Anchored; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D004369:Pentetic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D011868:Radioisotopes / Q000493:pharmacokinetics; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D011956:Receptors, Cell Surface / Q000378:metabolism*; D014055:Tomography, Emission-Computed / Q000379:methods*
D014408:Biomarkers, Tumor; D002352:Carrier Proteins; C108951:DTPA folate; D058973:Folate Receptors, GPI-Anchored; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D011956:Receptors, Cell Surface; D004369:Pentetic Acid; D005492:Folic Acid