title: Comparison of in vitro activities of ketolides, macrolides, and an azalide against the spirochete Borrelia burgdorferi.
abstract: Two ketolides, three macrolides, and one azalide were tested in vitro against 17 isolates of the B. burgdorferi s.l. complex. As measured in micrograms per milliliter, activity was highest for cethromycin (MIC at which 90% of the tested isolates were inhibited [MIC(90)], 0.0019 micro g/ml) and telithromycin (MIC(90), 0.0078 micro g/ml). Electron-microscope analysis and time-kill studies also supported enhanced effectiveness of both ketolides.
authors.affiliation: Institute of Medical Microbiology, University Hospital of Frankfurt, D-60596 Frankfurt/Main, Germany. k.hunfeld@em.uni-frankfurt.de
authors.forename: Klaus-Peter
authors.initials: KP
authors.lastname: Hunfeld
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Wichelhaus
authors.forename: Rebecca
authors.initials: R
authors.lastname: Rödel
authors.forename: Georg
authors.initials: G
authors.lastname: Acker
authors.forename: Volker
authors.initials: V
authors.lastname: Brade
authors.forename: Peter
authors.initials: P
authors.lastname: Kraiczy
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology*; D025065:Borrelia burgdorferi / Q000187:drug effects* / Q000648:ultrastructure; D004917:Erythromycin / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D048628:Ketolides; D008193:Lyme Disease / Q000382:microbiology; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001372:Aza Compounds; D048628:Ketolides; D018942:Macrolides; D004917:Erythromycin; C405499:cethromycin; C106791:telithromycin