Current therapy of ulcerative colitis in children.
Ulcerative colitis presents in childhood in 10% of those affected, usually with pancolitis. Important features in management include growth, development and avoidance of treatment toxicity. This review addresses the current treatment options including both the paediatric evidence-based experience and areas where paediatric practice is informed by adult studies. Standard treatments include sulfasalazine or 5-aminosalicylates, corticosteroids, purine derivatives (azathioprine or 6-mercaptopurine) and surgery. Other immunosuppressant therapies and the emerging roles for biological therapies and probiotics are discussed.
Bremner
Alan Ronald
AR
Division of Infection, Inflammation and Repair, University of Southampton Medical School, South Academic Block (Mailpoint 813), Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK. r.bremner@soton.ac.uk
Griffiths
David Mervyn
DM
Beattie
Robert Mark
RM
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001781:Blood Component Removal; D002648:Child; D002986:Clinical Trials as Topic; D003093:Colitis, Ulcerative / Q000178:diet therapy / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D004334:Drug Administration Schedule; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007167:Immunotherapy; D019936:Probiotics / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D007166:Immunosuppressive Agents