title: Attachment of artificial cartilage to underlying bone.
abstract: The key problem with artificial joint materials is obtaining quick and firm attachment onto the underlying bone. In developing artificial articular cartilage, composed of polyvinyl alcohol hydrogel (PVA-H), this problem was solved by using a composite osteo-chondral device (COD). This enables attachment within four weeks post-operation by massive bone ingrowth into the pores. The COD consists of PVA-H as an artificial cartilage and titanium fiber mesh (TFM) as porous artificial bone. In this study, the strength of the shear resistance force at the interface of the PVA-H and the TFM fabricated by injection molding and the changes in the mechanical properties of the PVA-H fabricated by high temperature during the injection-molding process were examined. The shear resistance force was strengthened markedly by using injection molding and no important deterioration of the PVA-H was found. Morphological examination of canine spines, to which artificial intervertebral discs made of the COD were implanted, showed good bonding of the COD with the vertebral bodies for an extended period of 30 months, and encouraged us to use the COD clinically.
authors.affiliation: Department of Orthopaedic Surgery, School of Medicine, Kyoto University. kushio@gakushikai.jp
authors.forename: Kazuyasu
authors.initials: K
authors.lastname: Ushio
authors.forename: Masanori
authors.initials: M
authors.lastname: Oka
authors.forename: Suong-Hyu
authors.initials: SH
authors.lastname: Hyon
authors.forename: Takashi
authors.initials: T
authors.lastname: Hayami
authors.forename: Shigeto
authors.initials: S
authors.lastname: Yura
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Matsumura
authors.forename: Junya
authors.initials: J
authors.lastname: Toguchida
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism*; D018786:Bone Substitutes / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D004285:Dogs; D011142:Polyvinyl Alcohol / Q000378:metabolism*; D019736:Prostheses and Implants; D013997:Time Factors; D023822:Tissue Engineering; D014025:Titanium / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; C062364:polyvinyl alcohol hydrogel; C101914:titanium fiber; D011142:Polyvinyl Alcohol; D014025:Titanium