Mepivacaine alters vascular responsiveness to vasoconstrictors in aortic rings from normal and aortic-banded rats.
The present study investigated the effects of mepivacaine on the response of rat aorta to vasoconstrictors in normal and aortic-banded animals. Cardiac hypertrophy was induced in Wistar rats by aortic banding, while sham-operated animals served as controls. Isolated aortic rings with or without endothelium were contracted with potassium chloride and phenylephrine in the presence of mepivacaine (10(-3) M). Maximal tension was measured at the highest concentration of potassium chloride and phenylephrine. Maximal response to potassium chloride was reduced in the presence of mepivacaine both in normal and aortic-banded rings. As regards the vascular reactivity to phenylephrine, aortic rings with intact endothelium from aortic-banded rats have shown increased response as compared to normal. After mepivacaine administration this difference between normal and aortic-banded rats was abolished. In conclusion, in a model of cardiac hypertrophy such as that of aortic-banding, increased response to alpha1-adrenergic stimulation is observed, which is blunted by mepivacaine administration.
Mourouzis
Constantinos
C
Department of Pharmacology, Medical School, University of Athens, 75 Mikras Asias Ave., 11527 Goudi, Athens, Greece.
Pantos
Constantinos
C
Mourouzis
Iordanis
I
Saranteas
Theodosios
T
Tesseromatis
Christina
C
Kostopanagiotou
Georgia
G
Karageorgiou
Chariclia
C
Varonos
Dennis
D
Cokkinos
Dennis
D
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001011:Aorta; D006332:Cardiomegaly; D003250:Constriction; D004730:Endothelium, Vascular / Q000187:drug effects; D008297:Male; D008619:Mepivacaine / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010656:Phenylephrine / Q000037:antagonists & inhibitors; D011189:Potassium Chloride / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar; D014662:Vasoconstrictor Agents / Q000037:antagonists & inhibitors*
D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D010656:Phenylephrine; D011189:Potassium Chloride; D008619:Mepivacaine