Synthesis of 2-(3'-azido- and 3'-amino-3'-deoxy-beta-D-ribofuranosyl)thiazole-4-carboxamide.
In view of biological activities of tiazofurin and azido or aminosugar nucleosides, novel azido- and amino-substituted tiazofurin derivatives (1 and 2) were efficiently synthesized starting from 1,2;5,6-di-O-isopropylidene-D-glucose.
Liang
Cheng Wu
CW
College of Pharmacy, Seoul National University, Seoul, Korea.
Kim
Myong Jung
MJ
Jeong
Lak Shin
LS
Chun
Moon Woo
MW
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009705:Nucleosides / Q000138:chemical synthesis / Q000494:pharmacology; D012254:Ribavirin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D009705:Nucleosides; D012254:Ribavirin; C033706:tiazofurin