title: Distribution dynamics of perfluorocarbon delivery to the lungs: an intact rabbit model.
abstract: Motivated by the goal of understanding how to most homogeneously fill the lungs with perfluorocarbon for liquid ventilation, we investigate the transport of liquid instilled into the lungs using an intact rabbit model. Perfluorocarbon is instilled into the trachea of the ventilated animal. Radiographic images of the perfluorocarbon distribution are obtained at a rate of 30 frames/s during the filling process. Image analysis is used to quantify the liquid distribution (center of mass, spatial standard deviation, skewness, kurtosis, and indicators of homogeneity) as time progresses. We compare the distribution dynamics in supine animals to those in upright animals for three constant infusion rates of perfluorocarbon: 15, 40, and 60 ml/min. It is found that formation of liquid plugs in large airways, which is affected by posture and infusion rate, can result in a more homogeneous liquid distribution than gravity drainage alone. The supine posture resulted in more homogeneous filling of the lungs than did upright posture, in which the lungs tend to fill in the inferior regions first. Faster instillation of perfluorocarbon results in liquid plugs forming in large airways and, consequently, more uniform distribution of perfluorocarbon than slower instillation rates in the upright animals.
authors.affiliation: Department of Biomedical Engineering, The University of Michigan, Ann Arbor, MI 48109, USA. joebull@umich.edu
authors.forename: J L
authors.initials: JL
authors.lastname: Bull
authors.forename: S
authors.initials: S
authors.lastname: Tredici
authors.forename: E
authors.initials: E
authors.lastname: Komori
authors.forename: D O
authors.initials: DO
authors.lastname: Brant
authors.forename: J B
authors.initials: JB
authors.lastname: Grotberg
authors.forename: R B
authors.initials: RB
authors.lastname: Hirschl
mesh_terms: D000818:Animals; D005466:Fluorocarbons / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007322:Instillation, Drug; D021061:Liquid Ventilation; D008168:Lung / Q000000981:diagnostic imaging / Q000378:metabolism*; D008962:Models, Theoretical; D011187:Posture; D011817:Rabbits; D013902:Radiography, Thoracic; D016683:Supine Position
chemical_list: D005466:Fluorocarbons