Modeling coincidence detection in nucleus laminaris.
A biologically detailed model of the binaural avian nucleus laminaris is constructed, as a two-dimensional array of multicompartment, conductance-based neurons, along tonotopic and interaural time delay (ITD) axes. The model is based primarily on data from chick nucleus laminaris. Typical chick-like parameters perform ITD discrimination up to 2 kHz, and enhancements for barn owl perform ITD discrimination up to 6 kHz. The dendritic length gradient of NL is explained concisely. The response to binaural out-of-phase input is suppressed well below the response to monaural input (without any spontaneous activity on the opposite side), implicating active potassium channels as crucial to good ITD discrimination.
Grau-Serrat
Victor
V
Department of Electrical and Computer Engineering, University of Maryland, College Park, MD 20742, USA.
Carr
Catherine E
CE
Simon
Jonathan Z
JZ
D000818:Animals; D001306:Auditory Pathways / Q000502:physiology*; D001933:Brain Stem / Q000502:physiology*; D002645:Chickens; D003198:Computer Simulation; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D013017:Sound Localization / Q000502:physiology*; D020305:Strigiformes