[Comparative study of three local ablation methods for transplanted hepatocellular carcinoma in mice].
OBJECTIVE
To observe the effects of three commonly used local ablation methods in the treatment of transplanted hepatocellular carcinoma in mice to provide experimental evidence for treating hepatocellular carcinoma that defies surgical removal.


METHODS
Mouse models of hepatocellular carcinoma were established by means of subcutaneous transplantation, and treatment results of the three ablation methods, namely percutaneous ethanol injection therapy (PEIT), percutaneous acetic acid injection therapy (PAIT) and percutaneous local cryosurgery therapy (PLCT), were compared.


RESULTS
The tumor inhibition rates of PLCT, PAIT and PEIT were 99.2%, 85.3%, and 72.8%, respectively. The rates for complete necrosis of the tumors were 100% (5/5), 60% (3/5), and 40% (2/5), with the survival time of 88.11+/-5.67, 86.67+/-7.26, and 72.89+/-12.86 days respectively.


CONCLUSIONS
All of the three local ablation methods can inhibit the tumor growth to various degrees and prolong the survival time of the tumor-bearing mice. PLCT may yield relatively better result than the other two methods.
Zhu
Wei-liang
WL
Department of Oncology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. duarion@sohu.com
Zhang
Jian
J
Zhang
Ji-ren
JR
Wang
Sen-ming
SM
Bu
Hai-ji
HJ
D019342:Acetic Acid / Q000008:administration & dosage*; D000279:Administration, Cutaneous; D000818:Animals; D003452:Cryosurgery; D000431:Ethanol / Q000008:administration & dosage*; D007267:Injections; D008114:Liver Neoplasms, Experimental / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation
D000431:Ethanol; D019342:Acetic Acid