Phagocyte priming as a prognostic indicator in the intensive care unit.
BACKGROUND
The purpose of this study was to study the temporal changes in circulating phagocyte respiratory burst activity and its relationship to mortality in intensive care unit (ICU) patients.


METHODS
Thirty-seven consecutive patients over a 3-week period were studied on their first, third, and seventh day of admission to the regional ICU in Northern Ireland. Blood samples were assayed for respiratory burst activity using luminol-enhanced whole blood chemiluminescence.


RESULTS
Compared with survivors, nonsurvivors exhibited significantly higher Acute Physiology and Chronic Health Evaluation II scores, a base deficit, and reduced phagocyte activity (median [interquartile range]) (24.00% [18.00%, 56.00%] vs. 38.00% [30.00%, 63.50%], p = 0.047, Mann-Whitney U test) on day 3 of admission to the ICU.


CONCLUSIONS
Temporal changes in phagocyte activation dependent on the underlying insult were seen in ICU patients. Furthermore, the degree of phagocyte activation was able to distinguish between survivors and nonsurvivors on day 3 of admission to the ICU. Nonsurvivors exhibited reduced phagocyte activation, suggesting patients at risk of mortality exhibit systemic anergy.
McCallion
Kevin
K
Department of Surgery, Queen's University of Belfast, Northern Ireland. k.mccallion@qub.ac.uk
McAuley
Danny F
DF
Harkin
Denis W
DW
McCarroll
Conor P
CP
Brown
Glenn E
GE
Lavery
Gavin
G
Gardiner
Keith R
KR
D018806:APACHE; D000368:Aged; D015703:Antigens, CD / Q000097:blood; D016022:Case-Control Studies; D004396:Coloring Agents; D003422:Critical Care; D016638:Critical Illness / Q000145:classification / Q000401:mortality* / Q000628:therapy; D016002:Discriminant Analysis; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007249:Inflammation / Q000276:immunology; D015850:Interleukin-6 / Q000097:blood; D008163:Luminescent Measurements; D008165:Luminol; D008297:Male; D008875:Middle Aged; D009660:Northern Ireland / Q000453:epidemiology; D010586:Phagocytes / Q000276:immunology; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D047888:Receptors, Tumor Necrosis Factor, Type I; D016897:Respiratory Burst / Q000276:immunology; D016019:Survival Analysis; D013997:Time Factors
D015703:Antigens, CD; D004396:Coloring Agents; D015850:Interleukin-6; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D008165:Luminol