Suitability of an E2 subunit vaccine of classical swine fever in combination with the E(rns)-marker-test for eradication through vaccination.
Vaccination with modified live vaccines (C-, GPE-minus strain) against Classical Swine Fever (CSF) is an efficient tool in its control. However, for monitoring infection in a vaccinated population, marker-vaccines are preferred. A review is given on the efficacy of the E2 marker-vaccine, Porcilis Pesti. Protection starts to come up at seven days pv. Reduction of horizontal virus transmission starts to show at 10 days pv, is almost complete at 14 days and complete at 21 days after a single vaccination. Single vaccination of pregnant sows hardly prevents vertical transmission. Double vaccination prevents horizontal transmission as measured by virus isolation from the contact pigs. Double vaccination of pregnant sows prevents vertical transmission in the majority of the piglets. Data on the second version of the accompanying test, Chekit-CSF-Marker, show in a negative population a specificity of 98.8%. In a set of reference sera the improved test compares well with the results of a VNT. In a challenge experiment all pigs seroconverted between 1 and 3 weeks after challenge.
van Aarle
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Intervet International BV, Boxmeer, The Netherlands. paul.vanaarle@intervet.com
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D006691:Classical Swine Fever / Q000175:diagnosis / Q000276:immunology* / Q000517:prevention & control; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000662:veterinary / Q000821:virology; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control; D014611:Vaccination / Q000662:veterinary*; D014759:Viral Envelope Proteins / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*; D014886:Weaning
D000914:Antibodies, Viral; D015415:Biomarkers; D014759:Viral Envelope Proteins; D014765:Viral Vaccines; C087086:glycoprotein E2, classical swine fever virus