Determination of repaglinide in pharmaceutical formulations by HPLC with UV detection.
A simple, precise and rapid RP-HPLC method was developed for the determination of repaglinide in pharmaceutical dosage forms. The method was carried out on a Shim-pack, RP-C18 column using a mixture of methanol: 0.1% v/v triethylamine (pH adjusted to 7 with orthophosphoric acid) and detection was done at 235 nm using nimesulide as internal standard. The linearity range was 0.1 to 0.5 microg/ml. The intra-day and inter-day precision were in the range of 0.48 to 1.01 and 0.15 to 1.15, respectively.
Gandhimathi
M
M
Department of Pharmaceutical Analysis, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore-641044, India. gands72@yahoo.co.in
Ravi
T K
TK
Renu
Susan Kurian
SK
D002138:Calibration; D002219:Carbamates / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation / Q000379:methods*; D007004:Hypoglycemic Agents / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010880:Piperidines / Q000032:analysis*; D015203:Reproducibility of Results
D002219:Carbamates; D007004:Hypoglycemic Agents; D004364:Pharmaceutical Preparations; D010880:Piperidines; C072379:repaglinide