title: Coenzyme Q10-containing composition (Immugen) protects against occupational and environmental stress in workers of the gas and oil industry.
abstract: The manual workers of the gas-and-oil extraction industry are exposed to hostile environmental and occupational conditions, resulting in elevated mortality and disability, due to chronic neurological and cardiovascular diseases. We evaluated the degree of oxidative stress, often associated with these pathological features, in the blood of manual and office employees of Russian Siberian extraction plants, and their psycho-physiological conditions. Results showed increased levels of spontaneous (p < 0.05) and PMA-activated (p < 0.01) luminol-dependent chemiluminescence (LDCL) in the white blood cells (WBC), and decreased peroxynitrite levels (p < 0.05) in the group of manual workers, and less markedly in the clerks and technicians working on spot, vs. a control group of city clerks. Superoxide release by WBC, and plasma/WBC membrane ubiquinol levels did not display major differences in the three groups. A relevant percentage of manual/office workers of extraction platforms presented impaired cardiovascular and neurological functions. The short term administration of a nutraceutical formulation based on coenzyme10, vitamin E, selenium, methionine and phospholipids led to significant improvement of cardiovascular parameters and psycho-emotional status, consistent with the normalization of LDCL and peroxynitrite production by WBC, with a good compliance to treatment confirmed by the increased blood levels of ubiquinol.
authors.affiliation: Department of Molecular Biology, Russian State Medical University, Moscow, Russia. korkin@aha.ru
authors.forename: Ludmila
authors.initials: L
authors.lastname: Korkina
authors.forename: Irina
authors.initials: I
authors.lastname: Deeva
authors.forename: Galina
authors.initials: G
authors.lastname: Ibragimova
authors.forename: Alexander
authors.initials: A
authors.lastname: Shakula
authors.forename: Antonio
authors.initials: A
authors.lastname: Luci
authors.forename: Chiara
authors.initials: C
authors.lastname: De Luca
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D003067:Coenzymes; D019587:Dietary Supplements; D004644:Emotions; D004777:Environment; D005260:Female; D006801:Humans; D007219:Industrial Oils; D007962:Leukocytes / Q000502:physiology; D008163:Luminescent Measurements; D008165:Luminol / Q000494:pharmacology; D008297:Male; D008715:Methionine / Q000008:administration & dosage; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology / Q000517:prevention & control; D016273:Occupational Exposure; D018384:Oxidative Stress; D030421:Peroxynitrous Acid / Q000097:blood; D010578:Petroleum; D010743:Phospholipids / Q000008:administration & dosage; D012426:Russia; D012643:Selenium / Q000008:administration & dosage; D012800:Siberia; D013481:Superoxides / Q000097:blood; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014451:Ubiquinone / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000097:blood; D014810:Vitamin E / Q000008:administration & dosage
chemical_list: D003067:Coenzymes; D010578:Petroleum; D010743:Phospholipids; D013481:Superoxides; D014451:Ubiquinone; D014810:Vitamin E; D030421:Peroxynitrous Acid; D008165:Luminol; D008715:Methionine; C024989:coenzyme Q10; D012643:Selenium; C003741:ubiquinol; D013755:Tetradecanoylphorbol Acetate