title: Generalized vulvar dysesthesia vs. vestibulodynia. Are they distinct diagnoses?
abstract: OBJECTIVE
  To evaluate prospectively whether generalized vulvar dysesthesia and vestibulodynia possess unique characteristics that support the theory of differing etiologies.
  
  
  METHODS
  Women with vulvar dysesthesia for a minimum of 3 months were enrolled at the University of Michigan in 2 clinics specializing in vulvar disorders. Informed consent was obtained. Participants completed a 27-page questionnaire and had a physical examination. Differentiation of generalized vulvar dysesthesia and vestibulodynia was based on tenderness to light pressure isolated to the introitus vs. pain beyond the introitus, respectively. We compared women with the 2 diagnoses to each other on demographic characteristics, exposures, pain characteristics and physical findings using t test, Mann-Whitney U and chi 2 analysis.
  
  
  RESULTS
  Between January 26, 2001, and August 28, 2002, we enrolled 39 women, aged 18-60 years, with tenderness localized to the vestibule (vestibulodynia) and 17 with generalized vulvar dysesthesia. Women in each diagnostic group were similar in demographic and exposure characteristics. The pain characteristics were similar between the 2 groups except that recent pain was rated as worse by those with generalized vulvar dysesthesia. Activities that aggravated or relieved the pain were similar. However, women with generalized vulvar dysesthesia were more likely to state that their pain was aggravated by sitting and by washing the area. Similar results were found when using "continuous" pain rather than vulvar pain location as the outcome variable.
  
  
  CONCLUSIONS
  The characteristics of women with generalized vulvar dysesthesia are similar to those with localized pain, supporting the theory that the 2 disorders may exhibit 2 presentations on a continuum of severity seen in vulvar dysesthesia rather than 2 distinct entities.
authors.affiliation: Departments of Family Medicine and of Obstetrics and Gynecology, University of Michigan, 1018 Fuller Street, Ann Arbor, MI 48109-0708, USA.
authors.forename: Barbara D
authors.initials: BD
authors.lastname: Reed
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Gorenflo
authors.forename: Hope K
authors.initials: HK
authors.lastname: Haefner
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D010146:Pain / Q000175:diagnosis / Q000473:pathology; D010147:Pain Measurement; D010292:Paresthesia / Q000175:diagnosis* / Q000473:pathology; D011446:Prospective Studies; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D014845:Vulvar Diseases / Q000175:diagnosis* / Q000473:pathology