title: [The effect of neck metastasis on survival following surgery for laryngeal cancer].
abstract: OBJECTIVE
  We evaluated the effect of neck metastasis on the survival rate of patients who underwent surgery for laryngeal cancer.
  
  
  METHODS
  A total of 256 patients who had undergone surgery between 1995 and 1999 were retrospectively reviewed. Of these, 186 patients (72%; 185 males, 1 female; mean age 57.5 years) who were accessible for follow-up were evaluated with respect to the localization and type of the primary tumor, neck metastasis, surgical procedures, and the survival. Survival rates were determined by the Kaplan-Meier method and compared by the log-rank test. The rates of neck metastasis and extracapsular spread in survivors and non-survivors were compared with the use of the chi-square test. The minimum follow-up period was two years (mean 41.2 months).
  
  
  RESULTS
  Twenty-nine patients died from locoregional recurrences or distant metastasis and six patients died from other causes. The cumulative survival period was 69 months (75 months and 54 months with or without neck metastasis, respectively; log rank test 27.96, p<0.0001). The rates of neck metastasis and extracapsular spread in survivors (22%, 33/151; 7%, 10/151) and non-survivors (69%, 20/29; 59%, 17/29) were significantly different (p<0.001).
  
  
  CONCLUSIONS
  Neck metastasis and cervical recurrence were found as the most important factors affecting the results of laryngeal cancer surgery.
authors.affiliation: Department of Otolaryngology (KBB Anabilim Dali), Medicine Faculty of Istanbul University, Istanbul, Turkey.
authors.forename: Yahya
authors.initials: Y
authors.lastname: Güldiken
authors.forename: Emre A
authors.initials: EA
authors.lastname: Yücel
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Solmaz
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozdemir
authors.forename: Kemal
authors.initials: K
authors.lastname: Değer
mesh_terms: D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000556:secondary; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D007825:Laryngectomy; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000401:mortality*; D012189:Retrospective Studies; D016019:Survival Analysis; D014421:Turkey / Q000453:epidemiology