title: Intrathecal meperidine decreases shivering during cesarean delivery under spinal anesthesia.
abstract: Shivering associated with spinal anesthesia is uncomfortable and may interfere with monitoring. We performed this prospective, double-blinded, and randomized study to determine whether intrathecal meperidine (0.2 mg/kg) decreases the incidence and intensity of shivering after spinal anesthesia for cesarean delivery. Forty parturients scheduled for nonemergent cesarean delivery were enrolled in two groups. Spinal anesthesia consisted of hyperbaric bupivacaine (0.75%; 10.5 mg), morphine 0.15 mg, and, in the experimental group, meperidine (0.2 mg/kg) or, in the control group, normal saline. Data collection, including sensory block level, blood pressure, core temperature, and shivering intensity, was performed every minute for 10 min, every 3 min for 33 min, and then every 5 min until the sensory level receded to L4. Time to highest sensory level, maximum number of blocked segments, sensory and motor blockade regression, and systolic blood pressure showed no difference between groups. The incidence of shivering was less (P < 0.02) in the meperidine group, as was its intensity (P < 0.003). Intrathecal meperidine (0.2 mg/kg) is effective in reducing the incidence and intensity of shivering associated with spinal anesthesia for cesarean delivery.
  
  
  CONCLUSIONS
  Previous studies have suggested that IV meperidine is helpful for treating intraoperative shivering. This study was undertaken to evaluate spinal meperidine and found that it decreases the incidence and intensity of shivering associated with spinal anesthesia for cesarean delivery.
authors.affiliation: Département d'Anesthésiologie, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, Canada.
authors.forename: Jean-Denis
authors.initials: JD
authors.lastname: Roy
authors.forename: Michel
authors.initials: M
authors.lastname: Girard
authors.forename: Pierre
authors.initials: P
authors.lastname: Drolet
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use*; D000773:Anesthesia, Obstetrical; D000775:Anesthesia, Spinal; D001034:Apgar Score; D002585:Cesarean Section; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008614:Meperidine / Q000008:administration & dosage / Q000627:therapeutic use*; D009407:Nerve Block; D011247:Pregnancy; D011446:Prospective Studies; D012768:Shivering / Q000187:drug effects*; D013997:Time Factors
chemical_list: D000701:Analgesics, Opioid; D008614:Meperidine