title: Determination of ampicillin and amoxycillin by flow injection chemiluminescence method based on their enhancing effects on the luminol-periodate reaction.
abstract: In this work, a new flow injection chemiluminescence method is described for the determination of ampicillin and amoxycillin. The method is based on the strong enhancing effects of these antibiotics on the luminol-periodate reaction. The present method allows the measurements of ampicillin in the range 0.02-1.0 mg/L range and amoxycillin in the range 0.1-10.0 mg/L range with the relative standard deviations within 0.8-2.0%. The sampling frequency was calculated about 90/h. The method was successfully applied to the determination of ampicillin and amoxycillin in pharmaceutical preparations. A brief discussion on the possible chemiluminescence reaction mechanism is presented.
authors.affiliation: Department of Chemistry, School of Science, Xi'an Jiaotong University, 710049, People's Republic of China. duli16@sina.com
authors.forename: Yinhuan
authors.initials: Y
authors.lastname: Li
authors.forename: Yuhai
authors.initials: Y
authors.lastname: Tang
authors.forename: Hong
authors.initials: H
authors.lastname: Yao
authors.forename: Junmei
authors.initials: J
authors.lastname: Fu
mesh_terms: D000658:Amoxicillin / Q000032:analysis*; D000667:Ampicillin / Q000032:analysis*; D000900:Anti-Bacterial Agents / Q000032:analysis*; D017022:Flow Injection Analysis / Q000379:methods*; D007202:Indicators and Reagents; D008163:Luminescent Measurements; D008165:Luminol / Q000737:chemistry*; D010504:Periodic Acid / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D010504:Periodic Acid; D008165:Luminol; D000667:Ampicillin; D000658:Amoxicillin; C009288:metaperiodate