The C-terminal ester of membrane anchored peptide ion channels affects anion transport.
Five heptapeptide derivatives, [CH3(CH2)17]2NCOCH2OCH2CO-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OR, in which R = ethyl, 2-propyl, heptyl, benzyl, and cyclohexylmethyl, were found to transport chloride anion through a phospholipid bilayer to varying extents dependent on the identity of R. It was concluded that the R group is a membrane anchor for the synthetic chloride channels.
Djedovic
Natasha
N
Department of Chemistry, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8103, St. Louis, MO 63110, USA.
Ferdani
Riccardo
R
Harder
Egan
E
Pajewska
Jolanta
J
Pajewski
Robert
R
Schlesinger
Paul H
PH
Gokel
George W
GW
D000838:Anions / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism; D004952:Esters / Q000737:chemistry*; D007473:Ion Channels / Q000737:chemistry* / Q000378:metabolism*; D017136:Ion Transport; D008081:Liposomes / Q000378:metabolism; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism
D000838:Anions; D002712:Chlorides; D004952:Esters; D007473:Ion Channels; D008081:Liposomes; D010455:Peptides; D010743:Phospholipids