title: X-linked dominant inheritance in palmoplantar keratoderma with leukokeratosis: a study of the pedigree of two cases.
abstract: Keratoderma of the palms and soles is not of rare occurrence. Its association with leukokeratosis of the mouth is well recognized. We describe two siblings having callosities like keratoderma over the weight bearing areas of soles, pressure areas of palms and palmar creases with leukokeratosis of cheeks. On study of the pedigree of these probands we could trace the trait transmission by a rare X-linked dominant mechanism.
authors.affiliation: Department of Dermatology & STD Dr. Ram Manohar Lohia Hospital, New Delhi-110001, India.
authors.forename: Prafulla Kumar
authors.initials: PK
authors.lastname: Sharma
authors.forename: Namita
authors.initials: N
authors.lastname: Rath
authors.forename: Ruchi
authors.initials: R
authors.lastname: Chauhan
authors.forename: Suresh Kumar
authors.initials: SK
authors.lastname: Sharma
authors.forename: Hemant Kumar
authors.initials: HK
authors.lastname: Kar
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005111:Extrachromosomal Inheritance; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000150:complications / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D008297:Male; D009059:Mouth Diseases / Q000150:complications / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D035781:Siblings