title: Association of alpha 2-macroglobulin polymorphisms and Alzheimer disease in Mainland Han Chinese.
abstract: This study used case-control method to investigate roles of two alpha 2-macroglobulin (A2M) polymorphisms, a 5-bp insertion/deletion (A2M-I/D) and an A-->G substitution (A2M-A/G), in the development of sporadic Alzheimer disease (AD) in Mainland Han Chinese. Our results showed a trend of lower D-carrying genotype frequency in APOE-epsilon 4 carrying AD patients than in corresponding control subjects (chi(2)=3.67, p=0.055). The ID/AA genotype frequency was lower in AD patients comparing with controls (chi(2)=4.04, p=0.044). In AD patients, the G-carrying genotype frequency was significantly higher in APOE-epsilon 4 carrier subgroup than in APOE-epsilon 4 non-carriers (chi(2)=7.38, OR=2.99, 95% CI: 1.33-6.71, p=0.007). These results indicated that A2M-D allele was probably a weak AD protective factor, and there was a possible interaction of APOE-epsilon 4 and A2M-G alleles to increase AD risk in Mainland Han Chinese.
authors.affiliation: National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, The Chinese Academy of Medical Sciences and The Peking Union Medical College, Beijing 100005, People's Republic of China.
authors.forename: Deng
authors.initials: D
authors.lastname: Chen
authors.forename: Jun-Wu
authors.initials: JW
authors.lastname: Zhang
authors.forename: Zhen-Xin
authors.initials: ZX
authors.lastname: Zhang
authors.forename: Ya-Ning
authors.initials: YN
authors.lastname: Wu
authors.forename: Qiu-Ming
authors.initials: QM
authors.lastname: Qu
mesh_terms: D017668:Age of Onset; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D019943:Amino Acid Substitution; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D017384:Sequence Deletion; D000511:alpha-Macroglobulins / Q000235:genetics*
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D000511:alpha-Macroglobulins