Endogenous urinary steroids in premenopausal women with uterine leiomyomas.
OBJECTIVE
To study the effect of endogenous steroids on the presence of uterine leiomyomas.


METHODS
Urine samples of 27 premenopausal women with leiomyomas and 25 age-matched healthy premenopausal women were collected. The concentration of estrogens and androgens in the urine samples of the two groups were determined using a gas chromatography mass spectrometer and the two groups were compared. To study metabolic changes in patients indirectly, the concentration ratios of precursor metabolite to product metabolite of the two groups were also compared.


RESULTS
Urinary concentrations of 17beta-estradiol, 5-androstene-3beta, 16beta, 17beta, triol, 11-keto-ethiocholanolone, 11beta-hydroxy-androsterone, 11beta-hydroxy-etiocholanolone, THS, THA, THE, alpha-cortol and beta-cortol were significantly higher in patients than in controls. The concentration ratios of 17beta-estradiol/estrone and 11/beta-hydroxy-ethiocholanolone/11beta-hydroxy-androsterone increased in patients.


CONCLUSIONS
The presence of uterine leiomyomas correlates with an increase in urinary concentrations of estrogens and androgens, and it appears to be caused by a decrease in patients' metabolism of steroids.
Jung
B H
BH
Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, Cheongryang, Seoul, South Korea.
Bai
S W
SW
Chung
B C
BC
D000328:Adult; D000728:Androgens / Q000652:urine*; D000737:Androstenols / Q000652:urine; D000738:Androsterone / Q000031:analogs & derivatives* / Q000652:urine; D016022:Case-Control Studies; D003345:Corticosterone / Q000031:analogs & derivatives* / Q000652:urine; D003350:Cortodoxone / Q000031:analogs & derivatives* / Q000652:urine; D003687:Dehydroepiandrosterone / Q000652:urine; D004958:Estradiol / Q000652:urine; D004967:Estrogens / Q000652:urine*; D004970:Estrone / Q000652:urine; D005043:Etiocholanolone / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007889:Leiomyoma / Q000378:metabolism* / Q000652:urine; D008875:Middle Aged; D011278:Pregnanes / Q000652:urine; D017697:Premenopause; D013761:Tetrahydrocortisone / Q000652:urine; D014594:Uterine Neoplasms / Q000378:metabolism* / Q000652:urine
D000728:Androgens; D000737:Androstenols; D004967:Estrogens; D011278:Pregnanes; C096314:tetrahydro-11-dehydrocorticosterone; D004970:Estrone; C006577:5-androstene-3,16,17-triol; D003687:Dehydroepiandrosterone; D004958:Estradiol; C003544:cortol; C002528:11 beta-hydroxyandrosterone; D013761:Tetrahydrocortisone; C009412:tetrahydro-11-deoxycortisol; D005043:Etiocholanolone; D000738:Androsterone; D003345:Corticosterone; D003350:Cortodoxone; C015962:11-ketoetiocholanolone