Future challenges for hematopoietic stem cell research.
This perspective summarizes several important advances in hematopoietic stem cell (HSC) biology in the past few years and places these advances in the context of future directions in stem cell research. The potential utility of stem cells for gene therapy, tissue engineering, and the treatment of neurological and other forms of disease is simply too significant to ignore, and yet our knowledge and ability to deliver these forms of therapy in a safe and efficacious manner will require additional advances in the understanding of the basic biology of stem cells.
Spangrude
Gerald J
GJ
Departments of Medicine and Pathology, University of Utah School of Medicine, RM 4C416, 30 N 1900 E, Salt Lake City, UT 84132-2408, USA. gspangrude@mac.com
D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods / Q000639:trends; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends*; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology* / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods* / Q000639:trends