Modulation of the beta1-3 voltage-gated sodium channels in rat vestibular and facial nuclei after unilateral labyrinthectomy and facial nerve section: an in situ hybridization study.
We investigated whether the production of the mRNAs for the auxiliary beta subunits of the Na channels are modulated in deafferented medial vestibular nucleus (MVN) and in axotomized facial motoneurons. No beta1-3 mRNAs modulation was detected at any time following unilateral labyrinthectomy in the deafferented and intact medial vestibular nucleus. In contrast, beta1 gene expression in the axotomized facial nucleus decreased compared to controls as soon as day post-lesion 3.
Vassias
I
I
LNRS (CNRS-Paris 5), UMR 7060 Centre Universitaire des Saints-Pères, 45 rue des Saints-Pères, 75270 Paris, Cedex 06, France.
Patko
T
T
Vidal
P-P
PP
de Waele
C
C
D000818:Animals; D001345:Autoradiography; D019771:Axotomy / Q000379:methods; D007758:Ear, Inner / Q000378:metabolism / Q000601:surgery*; D005154:Facial Nerve / Q000166:cytology / Q000378:metabolism* / Q000601:surgery; D017403:In Situ Hybridization; D008297:Male; D009046:Motor Neurons / Q000378:metabolism*; D015345:Oligonucleotide Probes / Q000378:metabolism; D013506:Otologic Surgical Procedures; D021122:Protein Subunits / Q000378:metabolism; D051381:Rats; D020318:Rats, Long-Evans; D015222:Sodium Channels / Q000378:metabolism*; D013997:Time Factors; D014726:Vestibular Nuclei / Q000378:metabolism* / Q000601:surgery
D015345:Oligonucleotide Probes; D021122:Protein Subunits; D015222:Sodium Channels