An easy sonochemical route for the encapsulation of tetracycline in bovine serum albumin microspheres.
A one-step sonochemical process starting with the native BSA and tetracycline was employed to encapsulate the antibiotic drug in microspheres of BSA. The tetracycline loading studies showed that the maximum tetracycline loading capacity was found to be 65%. The antimicrobial activity of the tetracycline loaded in BSA microspheres was demonstrated on two bacterial strains that are sensitive to tetracycline.
Avivi
S
S
Department of Chemistry, Bar-Ilan University, Ramat-Gan, 52900 Israel.
Nitzan
Y
Y
Dror
R
R
Gedanken
A
A
D002626:Chemistry, Pharmaceutical; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008863:Microspheres; D012710:Serum Albumin, Bovine / Q000737:chemistry* / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013752:Tetracycline / Q000737:chemistry* / Q000494:pharmacology; D014465:Ultrasonics
D012710:Serum Albumin, Bovine; D013752:Tetracycline