New aspects in placental drug transfer.
The human placenta is the interface between the mother and fetus in the uterus. Until recently it was generally believed that the uterus provides a protective environment for the fetus. It is now accepted that any chemical substance, including any therapeutic agent, administered to a mother is able to permeate across the placental barrier. Unfortunately, the placental transfer of substances and their distribution in the placenta is not well established. Understanding the structure of placental transporters and their function may serve as the ideal tool for drug development and the cure of mother and fetus during pregnancy.
Holcberg
Gershon
G
Department of Obstetrics and Gynecology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel. holcberg@bgumail.bgu.ac.il
Tsadkin-Tamir
Marina
M
Sapir
Olga
O
Huleihel
Mahmoud
M
Mazor
Moshe
M
Ben Zvi
Zvi
Z
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D001692:Biological Transport / Q000502:physiology; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics*; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D007004:Hypoglycemic Agents