title: Disseminated Aspergillus terreus infection arising from cutaneous inoculation treated with caspofungin.
abstract: A case of disseminated Aspergillus terreus infection in a patient with prolonged neutropenia after stem cell transplant for myeloma is reported. The isolate was resistant to amphotericin B in vitro, and the patient was successfully managed with surgical debridement and the recently licensed antifungal agent caspofungin. There are many challenges associated with treating invasive aspergillosis, particularly that due to A. terreus, and the early use of caspofungin should be considered.
authors.affiliation: Infectious Diseases and Microbiology, Imperial College, The Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. fiona.cooke@imperial.ac.uk
authors.forename: F J
authors.initials: FJ
authors.lastname: Cooke
authors.forename: E
authors.initials: E
authors.lastname: Terpos
authors.forename: J
authors.initials: J
authors.lastname: Boyle
authors.forename: A
authors.initials: A
authors.lastname: Rahemtulla
authors.forename: T R
authors.initials: TR
authors.lastname: Rogers
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000150:complications / Q000188:drug therapy*; D001230:Aspergillus / Q000254:growth & development*; D000077336:Caspofungin; D003881:Dermatomycoses / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D025141:Drug Resistance, Fungal; D054714:Echinocandins; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole / Q000627:therapeutic use; D055666:Lipopeptides; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000382:microbiology; D010455:Peptides / Q000627:therapeutic use*; D010456:Peptides, Cyclic; D033581:Stem Cell Transplantation / Q000009:adverse effects
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D010455:Peptides; D010456:Peptides, Cyclic; D017964:Itraconazole; D000666:Amphotericin B; D000077336:Caspofungin