title: Short report: requirement of b cells for delayed type hypersensitivity-like pathology after secondary infection with Leishmania major in resistant C57BL/6 mice.
abstract: B cell-deficient C57B1/6 (microMT) mice were resistant to Leishmania major after both primary and secondary parasite challenge. However, unlike in wild-type mice, secondary infection in microMT mice was not accompanied by a marked delayed type hypersensitivity-like response, and interferon-gamma (IFN-gamma) levels were approximately half of those in wild-type mice. These results suggest that B cells are involved in IFN-gamma production and the pathology of secondary infection.
authors.affiliation: Department of Biological Sciences, University of Northern Colorado, College of Arts and Sciences, Greeley, Colorado 80639, USA. gregory.dekrey@unco.edu
authors.forename: Gregory K
authors.initials: GK
authors.lastname: DeKrey
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Jones
authors.forename: M Lamine
authors.initials: ML
authors.lastname: Mbow
authors.forename: Claudia I
authors.initials: CI
authors.lastname: Brodskyn
authors.forename: Richard G
authors.initials: RG
authors.lastname: Titus
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D006968:Hypersensitivity, Delayed / Q000473:pathology*; D007371:Interferon-gamma / Q000096:biosynthesis; D018320:Leishmania major / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout
chemical_list: D007371:Interferon-gamma