title: Ursodeoxycholic acid treatment of idiopathic thrombocytopenic purpura with liver dysfunction.
abstract: Ursodeoxycholic acid (UDCA) is known to reduce immunoglobulin from B cells and cytokine production from T cells. We found that UDCA increased the platelet count in two idiopathic thrombocytopenic purpura (ITP) patients who have liver dysfunction. UDCA was tolerated and did not cause diarrhea in the amounts used. Further investigation is needed to evaluate the effectiveness of UDCA in ITP patients.
authors.affiliation: Department of Internal Medicine, Juntendo University Izu-Nagaoka Hospital, Shizuoka, Japan. yu-koike@lily.ocn.ne.jp
authors.forename: Michiaki
authors.initials: M
authors.lastname: Koike
authors.forename: Iwao
authors.initials: I
authors.lastname: Sekigawa
authors.forename: Kaol
authors.initials: K
authors.lastname: Ogawa
authors.forename: Noboru
authors.initials: N
authors.lastname: Iida
authors.forename: Kazuo
authors.initials: K
authors.lastname: Oshimi
mesh_terms: D000328:Adult; D005234:Fatty Liver / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000188:drug therapy*; D014580:Ursodeoxycholic Acid / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D014580:Ursodeoxycholic Acid