title: Duct-to-duct biliary anastomosis for patients with sclerosing cholangitis undergoing liver transplantation.
abstract: BACKGROUND
  Due to the association of strictures within the biliary ductal system, Roux-en-Y choledochojejunostomy has been the preferred method of anastomosis for liver transplant recipients with primary sclerosing cholangitis (PSC). The aim of this study was to evaluate duct-to-duct anastomosis in patients with PSC who undergo liver transplantation.
  
  
  METHODS
  Data were collected and evaluated based on demographics, type of anastomosis preformed, malignancies, outcomes comparisons, and survival.
  
  
  RESULTS
  Of the 60 patients transplanted for PSC, 58 were diagnosed PSC prior to transplantation and 2 were diagnosed on explant. The Roux-en-Y group (n = 38) were similar in age, gender, and race when compared to the duct-to-duct (d-d) group (n = 22). There were similar rates of anastomotic revisions when comparing d-d anastomosis with Roux-en-Y (2 [9.1%] versus 2 [5.3%], P = NS) owing to bile leaks. Based on radiologic interventions of the bile ducts, seven (18.4%) in the Roux-en-Y group had interventions compared to two (9.1%) in the duct-to-duct group (P = NS). There was also no difference in recurrence of PSC: three (7.9%) in the Roux-en-Y group compared to two (5.3%) in the duct-to-duct group (P = NS). Survival at 4 years were similar between each group (76.5% [+/- 0.07] Roux-en-Y versus 84.9% [+/- 0.08] duct-to-duct, P = NS).
  
  
  CONCLUSIONS
  Duct-to-duct anastomosis at the time of liver transplantation is both safe and efficacious when used in patients with PSC. Outcomes as described by surgical interventions, radiologic interventions, retransplantation, and survival were similar between groups.
authors.affiliation: Department of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: T G
authors.initials: TG
authors.lastname: Heffron
authors.forename: G A
authors.initials: GA
authors.lastname: Smallwood
authors.forename: T
authors.initials: T
authors.lastname: Ramcharan
authors.forename: L
authors.initials: L
authors.lastname: Davis
authors.forename: K
authors.initials: K
authors.lastname: Connor
authors.forename: E
authors.initials: E
authors.lastname: Martinez
authors.forename: A C
authors.initials: AC
authors.lastname: Stieber
mesh_terms: D000713:Anastomosis, Roux-en-Y / Q000379:methods; D000714:Anastomosis, Surgical / Q000379:methods*; D001652:Bile Ducts / Q000601:surgery*; D015209:Cholangitis, Sclerosing / Q000601:surgery*; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000379:methods* / Q000401:mortality; D008297:Male; D012008:Recurrence; D012189:Retrospective Studies; D016019:Survival Analysis