title: Plasma concentrations of tafenoquine, a new long-acting antimalarial agent, in thai soldiers receiving monthly prophylaxis.
abstract: We measured plasma tafenoquine concentrations in Thai soldiers given a monthly regimen of tafenoquine to determine whether these concentrations adequately suppressed malarial infections on the Thai-Cambodian border. After receiving a treatment course of artesunate and doxycycline, 104 male soldiers were administered a loading dose of tafenoquine (400 mg daily for 3 days), followed by tafenoquine monthly (400 mg every 4 weeks) for 5 months. Consecutive monthly mean (+/- standard deviation) trough plasma tafenoquine concentrations were 223+/-41, 127+/-29, 157+/-51, 120+/-24, and 88+/-20 ng/mL. Only 1 soldier developed malaria during the study. At the time of malaria diagnosis, his plasma tafenoquine concentration was 40 ng/mL, which was approximately 3-fold lower than the trough concentrations of the other soldiers. Although low tafenoquine concentrations appear to be uncommon, additional investigations are needed to determine the relationship between plasma tafenoquine concentrations and suppression of malaria.
authors.affiliation: Australian Army Malaria Institute, Enoggera, QLD, Australia. Mike.Edstein@defence.gov.au
authors.forename: Michael D
authors.initials: MD
authors.lastname: Edstein
authors.forename: David A
authors.initials: DA
authors.lastname: Kocisko
authors.forename: Douglas S
authors.initials: DS
authors.lastname: Walsh
authors.forename: Chirapa
authors.initials: C
authors.lastname: Eamsila
authors.forename: Bruce G
authors.initials: BG
authors.lastname: Charles
authors.forename: Karl H
authors.initials: KH
authors.lastname: Rieckmann
mesh_terms: D000328:Adult; D000634:Aminoquinolines / Q000097:blood*; D000962:Antimalarials / Q000097:blood*; D037621:Artemisinins / Q000097:blood; D000077332:Artesunate; D018890:Chemoprevention; D004311:Double-Blind Method; D004318:Doxycycline / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D008889:Military Personnel; D012717:Sesquiterpenes / Q000097:blood; D013785:Thailand
chemical_list: D000634:Aminoquinolines; D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C055852:tafenoquine; D000077332:Artesunate; D004318:Doxycycline