title: Association of apolipoprotein E polymorphism with blood lipids and maximal oxygen uptake in the sedentary state and after exercise training in the HERITAGE family study.
abstract: The relationship of apolipoprotein E (apo E) genotypes to plasma lipid and maximal oxygen uptake (Vo(2max)) was studied in the sedentary state and after a supervised exercise training program in black and white men and women. At baseline, the apo E 2/3 genotype was associated with the lowest, and apo E 3/4 and E4/4 with the highest low-density liporpotein (LDL) cholesterol and apo B levels in men and women of both races, while female (not male) carriers of apo E3 had higher high-density lipoprotein (HDL) cholesterol levels than carriers of other genotypes. Very-low-density lipoprotein (VLDL) cholesterol and triglyceride levels were significantly higher in carriers of both apo E2 and apo E4 in white men only. Racial and sex differences were noted in lipid responses to exercise training across genotypes with a significantly greater increase in HDL cholesterol observed only in white female carriers of apo E 2/3 and E3/3, as compared to apo E4/4. Apo E polymorphism was not found to be associated with Vo(2max) levels either in the sedentary state nor the Vo(2max) response to exercise training, contrary to previous reports.
authors.affiliation: Laboratory of Physiological Hygiene and Exercise Science, Division of Kinesiology, University of Minnesota, Minneapolis 55455, USA.
authors.forename: Arthur S
authors.initials: AS
authors.lastname: Leon
authors.forename: Kenji
authors.initials: K
authors.lastname: Togashi
authors.forename: Tuomo
authors.initials: T
authors.lastname: Rankinen
authors.forename: Jean-Piérre
authors.initials: JP
authors.lastname: Després
authors.forename: D C
authors.initials: DC
authors.lastname: Rao
authors.forename: James S
authors.initials: JS
authors.lastname: Skinner
authors.forename: Jack H
authors.initials: JH
authors.lastname: Wilmore
authors.forename: Claude
authors.initials: C
authors.lastname: Bouchard
mesh_terms: D000483:Alleles; D053329:Apolipoprotein E2; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D044383:Black People; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005190:Family; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D010101:Oxygen Consumption; D010807:Physical Endurance; D010809:Physical Fitness; D011110:Polymorphism, Genetic; D012727:Sex Characteristics; D044465:White People
chemical_list: D053329:Apolipoprotein E2; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids