title: A new acrylic tissue adhesive for conjunctival surgery: experimental study.
abstract: OBJECTIVE
  To evaluate the clinical efficacy and the clinical and histopathologic tolerance of a new acrylic tissue adhesive (ADAL-2) versus 8/0 polyglactin sutures (Vicryl) for its use in conjunctival surgery.
  
  
  METHODS
  Experimental study performed on New Zealand albino rabbits. The animals were divided into two groups. Surgery consisted of a conjunctival peritomy of 8 mm in the superior limbus followed by extensive subconjunctival dissection and creation of a flap by two radial cuts. The conjunctiva was then attached to the limbus again by the proposed acrylic tissue adhesive (ADAL-2) or 8/0 polyglactin suture depending on the group. Clinical efficacy of the closure of the conjunctival wound, either with adhesives or sutures, and the clinical and histopathologic tolerance were also evaluated 1, 7, 28 and 42 days after surgery.
  
  
  RESULTS
  Both conjunctival surgical closure methods were found to be equal in efficacy concerning their ability to fix the conjunctiva to the limbus. There were no significant clinical and histopathologic tolerance differences between the new tissue adhesive investigated (ADAL-2) and 8/0 polyglactin sutures (Vicryl). Histopathology showed no presence of the adhesive 28 days postoperatively.
  
  
  CONCLUSIONS
  ADAL-2 tissue adhesive is an efficient conjunctival closure method, very well tolerated by the ocular surface. Its sealing efficiency and its tolerance are similar to 8/0 polyglactin sutures. This new acrylic adhesive has a potential as an alternative for surgical conjunctival sealing in ophthalmic surgery.
authors.affiliation: Ophthalmology Department, Miguel Hernández University, Alicante, Spain. jlalio@oftalio.com
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Alió
authors.forename: Javier
authors.initials: J
authors.lastname: Gómez
authors.forename: Emilia
authors.initials: E
authors.lastname: Mulet
authors.forename: María M Mahiques
authors.initials: MM
authors.lastname: Bujanda
authors.forename: José M Martin
authors.initials: JM
authors.lastname: Martinez
authors.forename: Yennis
authors.initials: Y
authors.lastname: Molina
mesh_terms: D000179:Acrylates / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use* / Q000633:toxicity; D003228:Conjunctiva / Q000187:drug effects* / Q000473:pathology / Q000601:surgery*; D003487:Cyanoacrylates / Q000627:therapeutic use* / Q000633:toxicity; D005549:Foreign-Body Reaction / Q000209:etiology; D011098:Polyglactin 910; D011817:Rabbits; D013524:Surgical Flaps; D013537:Sutures; D014014:Tissue Adhesives / Q000627:therapeutic use* / Q000633:toxicity; D014945:Wound Healing / Q000187:drug effects*
chemical_list: C481620:ADAL-2; D000179:Acrylates; D001672:Biocompatible Materials; D003487:Cyanoacrylates; D014014:Tissue Adhesives; D011098:Polyglactin 910