title: Interleukin-10 gene promoter region polymorphisms in patients with type 1 diabetes and autoimmune thyroid disease.
abstract: Type 1 diabetes is a heterogeneous autoimmune disease and is frequently associated with other organ-specific autoimmune diseases, including autoimmune thyroid disease (AITD). Type 1 diabetic patients with AITD are known to show distinct clinical and immunological features from patients without AITD. This study investigated whether interleukin-10 (IL-10) gene promoter region polymorphisms are associated with susceptibility to type 1 diabetes and AITD. The frequency of -1082G/A, -819C/T, and -592C/A polymorphisms was analyzed in 54 type 1 diabetic patients with AITD, 74 type 1 diabetic patients without AITD, 124 nondiabetic patients with AITD, and 107 healthy subjects in a case-control study. No significant differences on the allele and genotype frequencies of three polymorphisms were found not only in type 1 diabetic patients with AITD compared with normal controls, but also between nondiabetic patients with AITD and healthy controls. The distribution of IL-10 gene haplotypes was also similar between both patient groups and normal controls. These results suggest that IL-10 gene promoter region polymorphisms are not associated with genetic susceptibility to type 1 diabetes and AITD.
authors.affiliation: First Department of Internal Medicine, Graduate School of Biochemical Sciences, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan.
authors.forename: Akane
authors.initials: A
authors.lastname: Ide
authors.forename: Eiji
authors.initials: E
authors.lastname: Kawasaki
authors.forename: Norio
authors.initials: N
authors.lastname: Abiru
authors.forename: Fuyan
authors.initials: F
authors.lastname: Sun
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Fukushima
authors.forename: Reiko
authors.initials: R
authors.lastname: Ishii
authors.forename: Ryoko
authors.initials: R
authors.lastname: Takahashi
authors.forename: Hironaga
authors.initials: H
authors.lastname: Kuwahara
authors.forename: Naruhiro
authors.initials: N
authors.lastname: Fujita
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kita
authors.forename: Misa
authors.initials: M
authors.lastname: Imaizumi
authors.forename: Katsuya
authors.initials: K
authors.lastname: Oshima
authors.forename: Toshiro
authors.initials: T
authors.lastname: Usa
authors.forename: Shigeo
authors.initials: S
authors.lastname: Uotani
authors.forename: Eri
authors.initials: E
authors.lastname: Ejima
authors.forename: Hironori
authors.initials: H
authors.lastname: Yamasaki
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Ashizawa
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi
mesh_terms: D001327:Autoimmune Diseases / Q000150:complications / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000235:genetics*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D013959:Thyroid Diseases / Q000150:complications / Q000235:genetics*
chemical_list: D016753:Interleukin-10