Irritant potential of some constituents from oleo-gum-resin of Commiphora myrrha.
The irritant potentials of essential oil and seven sesquiterpenoids compounds newly isolated from the oleo-gum-resin of Commiphora myrrha were investigated by open mouse ear assay. The essential oil, curzerenone, furanodiene-6-one and furanoeudesma-1,3-diene showed potent and persistent irritant effects while others possess least irritant potentials.
Saeed
M Asif
MA
Department of Pharmacy, University of the Punjab (Allama Iqbal Campus), Lahore 54000, Pakistan. moasif1605@hotmail.com
Sabir
A W
AW
D000818:Animals; D029744:Commiphora; D004305:Dose-Response Relationship, Drug; D005260:Female; D007249:Inflammation / Q000139:chemically induced*; D007509:Irritants / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology; D012116:Resins, Plant / Q000008:administration & dosage / Q000494:pharmacology*
D007509:Irritants; D010936:Plant Extracts; D010938:Plant Oils; D012116:Resins, Plant