Differential modulation of the antifungal activity of amphotericin B by natural and ent-cholesterol.
The addition of exogenous ent-cholesterol suppressed the antifungal activity of the amphotericin B when added to cultures of Candida albicans, but to a lesser extent than natural cholesterol. There were no detectable differences between added 2a or 2b on the antifungal activities of jaspamide or bengazole A, two unrelated antifungal natural products.
Richter
Rowena K
RK
Department of Chemistry, University of California, Davis, CA 95616, USA.
Mickus
Daniel E
DE
Rychnovsky
Scott D
SD
Molinski
Tadeusz F
TF
D000666:Amphotericin B / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D002784:Cholesterol / Q000737:chemistry* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013237:Stereoisomerism
D000935:Antifungal Agents; D000666:Amphotericin B; D002784:Cholesterol