title: [The relationship between hemoglobin adducts of trinitrotoluene and exposed level].
abstract: OBJECTIVE
  To explore the biomarkers for monitoring trinitrotoluene (TNT) exposure, the relationship between TNT hemoglobin adducts and TNT exposed level.
  
  
  METHODS
  Hemoglobin adducts (4A-Hb and 2A-Hb) were determined by GC-MS in 25 TNT exposed workers. TNT exposed level was evaluated by determining skin contaminated and inhaled TNT levels. The correlation between hemoglobin adducts level and TNT exposed level was analyzed.
  
  
  RESULTS
  There was a correlation between total TNT exposure level, especially skin exposure level, and 4A-Hb or 2A-Hb content. No significant difference was found between the slopes and intercepts of lin ear equation of (4A-Hb) vs TNT exposed level and linear equation of (4A-Hb +2A-Hb) vs TNT exposed level (P > 0.05).
  
  
  CONCLUSIONS
  Skin contamination is the major role of TNT exposure. TNT exposed level can be evaluated by determining the content of both 4A-Hb and 2A-Hb, and 4A-Hb is more suitable for monitoring TNT exposure.
authors.affiliation: Institute of Occupational Health, Chinese Academy of Preventive Medicine, Beijing 100050, China.
authors.forename: Wenjia
authors.initials: W
authors.lastname: Song
authors.forename: Yawen
authors.initials: Y
authors.lastname: Wang
authors.forename: Huifang
authors.initials: H
authors.lastname: Yan
authors.forename: Shuguang
authors.initials: S
authors.lastname: Leng
authors.forename: Yeping
authors.initials: Y
authors.lastname: Gu
authors.forename: Yuying
authors.initials: Y
authors.lastname: Liu
authors.forename: Yuxin
authors.initials: Y
authors.lastname: Zheng
mesh_terms: D004784:Environmental Monitoring / Q000379:methods*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D016273:Occupational Exposure; D012867:Skin / Q000187:drug effects; D014303:Trinitrotoluene / Q000378:metabolism*
chemical_list: D006454:Hemoglobins; D014303:Trinitrotoluene