[The polymorphism of delta-aminolevulinic acid dehydratase and genetic susceptibility to lead toxicity in Uighur and Yi population in China].
OBJECTIVE
To investigate the polymorphism of delta-aminolevulinic acid dehydratase(ALAD) and the genetic susceptibility to lead toxicity in Uighur and Yi population in China.


METHODS
The ALAD genotypes were determined by PCR and MspI restriction fragment length polymorphism techniques in 214 Uighur individuals from Xinjiang autonomous region and 144 Yi individuals from Yunnan province. The correlation between the polymorphism of ALAD and blood lead levels, and the factors affecting the latter were explored.


RESULTS
The frequencies of the allele ALAD1 and ALAD2 in Uighur are 0.91 and 0.09; and in Yi are 0.98 and 0.02 respectively. In Uighur the average blood lead level was (76 +/- 4) microgram/L, and 25.7% individuals with blood lead level > or = 100 micrograms/L. In Yi the average blood lead level was (50 +/- 16) microgram/L, and 6.3% individuals with blood lead level > or = 100 micrograms/L. However, no statistic correlation between the distribution of ALAD alleles and the blood lead level was found in both populations.


CONCLUSIONS
The genetic susceptibility of ALAD polymorphism to lead toxicity may exhibit in a lead dose-dependent manner.
Lu
Jing
J
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Bejing 100050, China.
Lu
Xinfang
X
Cui
Tao
T
Xie
Guangyun
G
Wu
Rongguo
R
Zhang
Chen
C
He
Xiwen
X
D002681:China / Q000208:ethnology; D004305:Dose-Response Relationship, Drug; D020022:Genetic Predisposition to Disease; D006801:Humans; D007854:Lead / Q000097:blood / Q000633:toxicity*; D011110:Polymorphism, Genetic; D000623:Porphobilinogen Synthase / Q000235:genetics*
D007854:Lead; D000623:Porphobilinogen Synthase