Inflammatory bowel disease: Crohn's disease and the success of NODern genetics.
The inflammatory bowel diseases (IBDs), Crohn's disease and ulcerative colitis, are multifactorial in etiology, but a major causative role for genetic factors has long been recognized. Recent advances in genetic technologies have made dissection of the genes underlying common diseases possible; consequently, there is an emerging understanding of the inherited factors that predispose to IBD. In this review, we summarize current information on the genetics of IBD, emphasizing the discovery of CARD15 variants as susceptibility alleles for Crohn's disease and the impact of this discovery on patient care and in delineating pathogenesis of this complex disease.
Newman
Bill
B
Genomic Medicine Division, University Health Network and the Department of Medicine, University of Toronto and Mount Sinai Hospital, Toronto, Ont.
Siminovitch
Katherine
K
D002352:Carrier Proteins / Q000235:genetics*; D002885:Chromosomes, Human, Pair 16; D003424:Crohn Disease / Q000235:genetics* / Q000628:therapy; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D053473:Nod2 Signaling Adaptor Protein; D012307:Risk Factors
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein