title: Material properties of various intraocular lenses in an experimental study.
abstract: BACKGROUND
  With the recent introduction of small-incision cataract surgery, requirements for intraocular lens (IOL) flexibility, strength and hydrophilicity have rapidly evolved. The IOL surface, however, remains a critical factor influencing uveal biocompatibility.
  
  
  OBJECTIVE
  To objectively quantify factors of material properties of various IOLs using contact angle measurements, differential scanning calorimetry, dynamic-mechanical measurements and scanning electron microscopy.
  
  
  METHODS
  In our study, 17 currently available IOLs were investigated using contact angle measurements to assess hydrophilicity and biocompatibility, as well as differential scanning calorimetry for the estimation of glass transition temperature. Mechanical capacity and flexibility were investigated using dynamic-mechanical measurements. Additional analysis of the IOL surface was performed using scanning electron microscopy.
  
  
  RESULTS
  The contact angle measurements of the studied IOLs revealed similar values within each group. The silicone IOLs had values between 106 and 119 degrees. The PMMA IOLs were found to have a narrower range of values, between 73.2 and 75.5 degrees. Lenses made of hydrogel had values between 59.2 and 69.1 degrees. The heparin-modified surface showed the lowest contact angle of 56.5 degrees. The glass transition temperature was determined by dynamic differential scanning calorimetry. The resulting values were between 118.8 and 113.5 degrees C for PMMA IOLs, 15.5 and 14.0 degrees C for acrylic IOLs, and -91.7 and -119.6 degrees C for silicone IOLs. The dynamic-mechanical measurements revealed that PMMA lenses manifested characteristics similar to glass, whereas silicone lenses had characteristics similar to rubber. Acrylic lenses were between rubber and glass. Scanning electron microscopy revealed smooth dispersion of fibrin on hydrophobic IOLs and a relative lack of fibrin adhesion on hydrophilic materials.
  
  
  CONCLUSIONS
  These results demonstrate that material properties of various IOL materials are consistent within classes of IOL materials. This suggests that the intraoperative and postoperative behavior of an IOL is predictable and related to its composition, thus allowing surgeons to choose IOLs more appropriate for different surgical situations and individual patient characteristics.
authors.affiliation: Department of Ophthalmology, Johannes Gutenberg University, Mainz, Germany. manatehrani@hotmail.com
authors.forename: Mana
authors.initials: M
authors.lastname: Tehrani
authors.forename: H Burkhard
authors.initials: HB
authors.lastname: Dick
authors.forename: Beate
authors.initials: B
authors.lastname: Wolters
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Pakula
authors.forename: Evan
authors.initials: E
authors.lastname: Wolf
mesh_terms: D000179:Acrylates; D002152:Calorimetry, Differential Scanning; D004548:Elasticity; D004867:Equipment Design; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D007910:Lenses, Intraocular; D008855:Microscopy, Electron, Scanning; D012828:Silicones
chemical_list: D000179:Acrylates; D012828:Silicones; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C036658:acrylic acid