[New diagnostic approaches in malignant B-cell lymphomas].
The new WHO classification of B-cell neoplasms published in 2001 gathers leukaemia and lymphoma. This classification highlights the stage of differentiation of the tumour cell. It groups B-cell neoplasms morphology, histology (nodular or diffuse pattern, cell morphology), immunophenotypes, cytogenetic, molecular abnormalities and clinical data. Recent advances of the normal B cell differentiation understanding and the development of new types of analysis have shown that mature B-cell neoplasms appear to recapitulate stages of normal B-cell differentiation, leading to such a new classification.
Benattar
L
L
Unité de télépathologie, Laboratoire central d'hématologie, Hôpital Necker-enfants malades, Paris.
Flandrin
G
G
D001402:B-Lymphocytes / Q000502:physiology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000145:classification / Q000175:diagnosis* / Q000209:etiology