Sodium-wasting nephropathy caused by cisplatin in a patient with small-cell lung cancer.
We describe a case of severe hyponatremia following chemotherapy administration in a patient with small-cell lung cancer. There was no evidence of the syndrome of inappropriate antidiuretic hormone (SIADH) secretion. The clinical and laboratory findings were consistent with a sodium-wasting nephropathy complicating cisplatin administration. There are few well-documented reports of cisplatin-associated hyponatremia in the medical literature. We have summarized the relevant literature and attempted to define the differential diagnosis of hyponatremia in this setting. Most cases are accounted for by sodium-losing nephropathy of SIADH, but many reported cases contain insufficient data for classification. Appropriate attention to the evaluation of hyponatremia following platinum-based chemotherapy is needed to properly treat these conditions.
Iyer
Akila V
AV
Veterans Affairs Medical Center, Washington, DC 20422, USA.
Krasnow
Steven H
SH
Dufour
D Robert
DR
Arcenas
Anthony S
AS
D000970:Antineoplastic Agents / Q000009:adverse effects*; D015415:Biomarkers / Q000097:blood; D001806:Blood Urea Nitrogen; D018288:Carcinoma, Small Cell / Q000097:blood / Q000188:drug therapy*; D002945:Cisplatin / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D003937:Diagnosis, Differential; D006801:Humans; D007010:Hyponatremia / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis*; D007177:Inappropriate ADH Syndrome / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis; D007674:Kidney Diseases / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis*; D008175:Lung Neoplasms / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000097:blood; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents; D015415:Biomarkers; D012964:Sodium; D003404:Creatinine; D002945:Cisplatin