title: Bronchial epithelial-myoepithelial carcinoma.
abstract: Epithelial-myoepithelial tumor is extremely rare as a pulmonary neoplasm. Only 20 cases have been reported to date, of which 14 were malignant. We report a case of intrabronchial epithelial-myoepithelial carcinoma in a 73-year-old man with a history of heavy smoking. The tumor was well-circumscribed and caused distal airway obstruction. Histologically, the tumor showed glandular and solid architecture. The glands were composed of an inner layer of epithelial cells and an outer layer of myoepithelial cells. The solid areas consisted of spindle-shaped myoepithelial cells. Immunohistochemical staining was positive for p53 and c-Kit (CD117). Focal atypia and increased mitotic activity were present, but no vascular invasion or nodal metastasis was identified.
authors.affiliation: Department of Pathology, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA. kru@tufts-nemc.org
authors.forename: Kun
authors.initials: K
authors.lastname: Ru
authors.forename: Amitabh
authors.initials: A
authors.lastname: Srivastava
authors.forename: Arthur S
authors.initials: AS
authors.lastname: Tischler
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D002283:Carcinoma, Bronchogenic / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008297:Male; D009208:Myoepithelioma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*; D014057:Tomography, X-Ray Computed