[HDL-cholesterol: role of its dosage in the assessment of cardiovascular risk].
The interest of HDL-cholesterol (HDLC) to evaluate a cardiovascular risk has been studied since many years. According to Framingham Heart studies, this factor is inversely correlated to a future ischaemic heart disease. At high level, HDLC is considered as a cardiovascular protecting factor, and is known since few years as "good cholesterol". In the year 2000, the ANAES (Agence nationale de l'accréditation et évaluation en santé) has redefined the role of HDLC in the exploration of dyslipidaemia. In the case of a cardiovascular-risk history, HDLC, with total cholesterol, triglycerides, and LDL-cholesterol (by Friedewald method) will be analyzed. Usually, HDLC is not very accessible to conventional treatments. So, according to ANAES, the treatment of dyslipidaemia will be based on LDL-cholesterol levels only. Nevertheless, HDLC is a major lipid factor to evaluate a cardiovascular risk. The object of this review is, on one hand, to situate HDLC in the evaluation of cardiovascular risk, by showing its key role in lipid metabolism, and, on the other hand, to report the main direct assays of this parameter.
Guinchard-Foulon
E
E
Laboratoire de biochimie et biologie moléculaire, Hôpital cardiovasculaire et pneumologique Louis Pradel, 28 avenue Doyen Lepine, 69500 Bron.
Rodriguez-Lafrasse
C
C
Rousson
R
R
D000924:Anticholesteremic Agents / Q000627:therapeutic use; D001774:Blood Chemical Analysis / Q000379:methods; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D008076:Cholesterol, HDL / Q000097:blood*; D006801:Humans; D009765:Obesity / Q000150:complications; D012307:Risk Factors
D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL