Mapping by waves. Patterned spontaneous activity regulates retinotopic map refinement.
A role for spontaneous spiking activity in shaping neuronal circuits has frequently been debated. Analyses of retinotopy in mutant mice with reduced correlated firing among neighboring retinal cells by Grubb et al. and McLaughlin et al. in this issue of Neuron indicate the importance of patterned spontaneous activity for retinotopic map refinement in subcortical visual targets.
Eglen
Stephen J
SJ
Institute for Adaptive and Neural Computation, School of Informatics, University of Edinburgh, 5 Forrest Hill, Edinburgh, EH1 2QL, Scotland.
Demas
Jay
J
Wong
Rachel O L
RO
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D006801:Humans; D009434:Neural Pathways / Q000502:physiology; D010775:Photic Stimulation; D012160:Retina / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000502:physiology