Serial analysis of gene expression provides new insights into regulatory T cells.
It is now possible to induce donor-specific transplantation tolerance in adult rodents using a number of therapeutic strategies. Such peripheral tolerance is maintained by regulatory CD4+ T cells, not only in transplantation models, but also in autoimmunity. Differential gene expression analyses have been used to identify potential new markers for regulatory T cells, aiming to reveal new insights into their mechanisms of action, and to find novel targets for therapeutic manipulation of the immune system.
Cobbold
Stephen P
SP
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. stephen.cobbold@path.ox.ac.uk
Adams
Elizabeth
E
Graca
Luis
L
Waldmann
Herman
H
D000818:Animals; D015415:Biomarkers; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism*; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism
D015415:Biomarkers