title: NK cell and DC interactions.
abstract: Recent interest has focused on interactions between natural killer (NK) cells and dendritic cells (DCs). In vitro and in vivo studies have demonstrated various effects of NK-DC interactions, including activation and cytokine production, maturation of DCs and NK-cell lysis of certain autologous DCs. These interactions are important during an immune response in vivo, however, it remains unclear where in the body NK cells and DCs might interact and whether observed in vitro crosstalk between these cell types happens in vivo. We propose evidence for at least two potential locations of in vivo interactions for human NK cells and DCs, including sites of inflammation and lymph nodes.
authors.affiliation: The James Cancer Hospital and The Comprehensive Cancer Center, The Ohio State University, 458A Starling-Loving Hall, 320 West 10th Avenue, Columbus, OH 43210, USA.
authors.forename: Megan A
authors.initials: MA
authors.lastname: Cooper
authors.forename: Todd A
authors.initials: TA
authors.lastname: Fehniger
authors.forename: Anja
authors.initials: A
authors.lastname: Fuchs
authors.forename: Marco
authors.initials: M
authors.lastname: Colonna
authors.forename: Michael A
authors.initials: MA
authors.lastname: Caligiuri
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008198:Lymph Nodes; D015398:Signal Transduction / Q000276:immunology*