Fed-batch fermentation of Lactobacillus lactis for hyper-production of L-lactic acid.
A fed-batch fermentation of Lactobacillus lactis to produce L-lactic acid was developed in which the residual glucose concentration in the culture was used to control a continuous feeding strategy. Up to 210 g L-lactic acid l(-1) (97% yield) was obtained. The maximal dry cell was 2.7 g l(-1) and the average L-lactic acid productivity was 2 g l(-1) h(-1).
Bai
Dong-Mei
DM
Department of Biochemical Engineering, School of Chemical Engineering & Technology, Tianjin University, Tianjin 300072, PR China.
Wei
Qiang
Q
Yan
Zhi-Hui
ZH
Zhao
Xue-Ming
XM
Li
Xin-Gang
XG
Xu
Shi-Min
SM
D019149:Bioreactors / Q000382:microbiology*; D018929:Cell Culture Techniques / Q000379:methods*; D002455:Cell Division / Q000502:physiology; D005285:Fermentation / Q000502:physiology; D005947:Glucose / Q000378:metabolism*; D019344:Lactic Acid / Q000096:biosynthesis*; D007778:Lactobacillus / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism*; D011786:Quality Control
D019344:Lactic Acid; D005947:Glucose