A ten-year-old boy with a pulmonary nodule secondary to Cryptococcus neoformans: case report and review of the literature.
Pulmonary cryptococcosis is an uncommonly recognized disease of childhood. Among immunocompetent and non-HIV-infected individuals, pulmonary cryptococcosis may be asymptomatic or present with chronic, nondescript symptomatology. In this report we describe a 10-year-old with malignant fibrous histiocytoma of bone and a pulmonary nodule secondary to Cryptococcus neoformans. We use this case as a background to review the pediatric literature regarding pulmonary cryptococcosis and to discuss the utility of immunohistochemistry for diagnosis of this clinical entity.
Sweeney
Daniel A
DA
Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Caserta
Mary T
MT
Korones
David N
DN
Casadevall
Arturo
A
Goldman
David L
DL
D000935:Antifungal Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D001859:Bone Neoplasms / Q000276:immunology / Q000628:therapy; D002648:Child; D003453:Cryptococcosis / Q000175:diagnosis* / Q000188:drug therapy; D003455:Cryptococcus neoformans / Q000302:isolation & purification*; D005500:Follow-Up Studies; D018219:Histiocytoma, Benign Fibrous / Q000276:immunology / Q000628:therapy; D006801:Humans; D016867:Immunocompromised Host; D007150:Immunohistochemistry; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D009894:Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000935:Antifungal Agents