title: Hemolysis in an electromechanical driven pulsatile total artificial heart.
abstract: A motor rotation in an electromechanically-driven pulsatile total artificial heart (TAH) may influence hemolysis. This study is designed to evaluate motor rotational conditions of the TAH and choose a suitable condition to obtain the least hemolytic characteristics. The TAH was driven in two motor rotational conditions: a constant motor rotational speed (rpm) mode (mode A) and a gradually increasing rpm mode (mode B). In these two modes, a maximum dP/dt value and a degree of hemolysis were measured and compared. The TAH was connected to an in vitro testing loop. In each mode, the TAH was driven with a fixed pumping rate of 100 bpm. A preload and an afterload were held at 15 and 100 mm Hg, respectively. The outflow of the TAH was maintained at 4.0 L/min. The maximum dP/dt in mode A and mode B was 5914 +/- 405 mm Hg/s and 2953 +/- 191 mm Hg/s, respectively. The NIH value obtained from mode A and mode B was 0.063 +/- 0.005 g/100 L and 0.026 +/- 0.003 g/100 L, respectively. The results demonstrated that the TAH driven in a gradually increasing rpm mode reduces both a maximum dP/dt value and a degree of hemolysis. The gradually increasing rpm mode is a suitable driving condition to obtain the least hemolytic characteristics.
authors.affiliation: Department of Cardiovascular Surgery, Chiba, Japan. acc23130@pop17.odn.ne.jp
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ohashi
authors.forename: Aron
authors.initials: A
authors.lastname: de Andrade
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Nosé
mesh_terms: D001696:Biomechanical Phenomena; D004867:Equipment Design / Q000379:methods; D006354:Heart, Artificial / Q000009:adverse effects*; D006461:Hemolysis / Q000502:physiology*; D006801:Humans; D008422:Materials Testing / Q000379:methods*