[C. elegans as a model for human inherited degenerative diseases].
The nematode C. elegans is an established model for developmental biology. Since the early 90's, this simple model organism has been increasingly used for studying human disease pathogenesis. C. elegans models based either on the mutagenesis of human disease genes conserved in this nematode or transgenesis with disease genes not conserved in C. elegans show several features that are observed in mammalian models. These observations suggest that the genetic dissection and pharmacological manipulation of disease-like phenotypes in C. elegans will shed light on the cellular mechanisms that are altered in human diseases, and the compounds that may be used as drugs. This review illustrates these aspects by commenting on two inherited degenerative diseases, Duchenne's muscular dystrophy and Huntington's neurodegenerative disease.
Ségalat
Laurent
L
Cnrs-CGMC, Université Lyon-1 Claude Bernard, 43, boulevard du 11 Novembre, 69622 Villeurbanne, France.
Néri
Christian
C
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000502:physiology*; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease; D006801:Humans; D006816:Huntington Disease / Q000235:genetics* / Q000503:physiopathology*; D020388:Muscular Dystrophy, Duchenne / Q000235:genetics* / Q000503:physiopathology*; D010641:Phenotype