Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia).
The commercially important antihyperglycemic agent Rosiglitazone 1(Avandia) has been prepared in high purity by a multi-step, polymer-assisted solution phase (PASP) synthesis without the need for the conventional chromatographic purification of any intermediates.
Li
Xin
X
Department of Chemistry, University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW.
Abell
Chris
C
Warrington
Brian H
BH
Ladlow
Mark
M
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000302:isolation & purification; D008956:Models, Chemical; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry; D000077154:Rosiglitazone; D012996:Solutions / Q000737:chemistry; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000302:isolation & purification
D007004:Hypoglycemic Agents; D011108:Polymers; D012996:Solutions; D045162:Thiazolidinediones; D000077154:Rosiglitazone