title: Portal vein pressure and graft oxygen consumption monitoring during liver transplantation.
abstract: Abnormal splanchnic circulation (ASC) is often detected too late, when hepatic circulation is already irreversibly compromised. If we could detect surgical or metabolic problems early after graft reperfusion, we might be able to correct them immediately before the damage becomes irreversible. The aim of this study was to determine if ASC can be predicted early after liver transplantation (LT) using portal vein pressure measurements and graft oxygen consumption monitoring.
  
  
  METHODS
  Twenty-patients (13 men, 7 women of mean age 46 years) undergoing LT with the piggyback technique for hepatitis C virus (HCV)/hepatitis B virus (HBV)-related cirrhosis were retrospectively divided in two groups. Group A (16 patients), in which LT was successful, and group B (4 patients) in which LT was unsuccessful because of primary nonfunction (2 patients), infrahepatic portal vein thrombosis (1 patient), or hepatic vein kinking (1 patient). We then compared the portal blood pressure values and the prehepatic and posthepatic oxygen content difference (p-pDO(2)) before portal clamping; at the end of anhepatic phase; 5, 15, and 25 minutes after portal vein (PV) reperfusion; and 5, 20, 40, and 100 minutes after hepatic artery anastomosis.
  
  
  RESULTS
  Early after graft reperfusion; portal pressure decreased to levels lower than that at baseline in group A, but remained high until the end of surgery in group B. At the end of surgery, p-pDO(2) increased more among group B than group A.
  
  
  CONCLUSIONS
  ASC, specifically an increased PV resistance, can be predicted early after LT by portal vein pressure measurements and graft oxygen consumption monitoring.
authors.affiliation: Dipartimento di Anestesiologia, Ospedale San Martino e Cliniche Universitarie Convenzionate, Genoa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Ardizzone
authors.forename: E
authors.initials: E
authors.lastname: Andorno
authors.forename: M
authors.initials: M
authors.lastname: Demartini
authors.forename: M
authors.initials: M
authors.lastname: Centenaro
authors.forename: A
authors.initials: A
authors.lastname: Pellizzari
authors.forename: F
authors.initials: F
authors.lastname: Panaro
authors.forename: N
authors.initials: N
authors.lastname: Morelli
authors.forename: E
authors.initials: E
authors.lastname: Riccò
authors.forename: U
authors.initials: U
authors.lastname: Valente
authors.forename: C
authors.initials: C
authors.lastname: Siani
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006509:Hepatitis B / Q000601:surgery; D006526:Hepatitis C / Q000601:surgery; D006801:Humans; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative / Q000379:methods; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000502:physiology*; D010313:Partial Pressure; D011169:Portal Vein
chemical_list: D006454:Hemoglobins; D010100:Oxygen