title: Small cell lung cancer: from molecular biology to novel therapeutics.
abstract: Small cell lung cancer (SCLC) is an aggressive tumor which metastasizes early. Patients with this disease have a poor prognosis even with immediate treatment. Because of the aggressive nature of this disease, all aspects of this tumor are studied extensively. This review will provide an update of the biology of SCLC at both the molecular and cellular levels. Cellular pathways and their relationship to cellular function will also be discussed. Treatment of both primary limited- and extensive-stage diseases as well as recurrent disease will be discussed including chemotherapy, thoracic radiotherapy, and surgery. The role of novel therapeutics being investigated will also be addressed.
authors.affiliation: Tufts- New England Medical Center, Tufts University School of Medicine, Boston, MA, USA.
authors.forename: Evan
authors.initials: E
authors.lastname: Pisick
authors.forename: Simha
authors.initials: S
authors.lastname: Jagadeesh
authors.forename: Ravi
authors.initials: R
authors.lastname: Salgia
mesh_terms: D018288:Carcinoma, Small Cell / Q000209:etiology / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology / Q000628:therapy*