[Prognostication of hematotoxicity for radio- and chemotherapy in patients with breast cancer].
The effectiveness of radiation and chemotherapy for breast cancer depends on individual response to drug-induced toxicity. The response can be evaluated by means of myelodepression. To this end, changes in leukocyte DNA level after ex vivo gamma radiation test were used as a criterion. Patients, aged 29-78, with tumors stage IIIB-IV received standard radiotherapy (50 Gy) or cyclophosphamide-methotrexate-5-fluorouracil (CMF). Clodronate alone was given to 26 patients and prior to a CMF course. The method proved prognostically effective since it revealed a significant inverse relationship between S-index and leukocyte nadir for both modalities. However, chemotherapy resulted in more pronounced leukopenia. With clodronate administration, the correlation was not significant. When clodronate was supplemented with CMF chemotherapy involved a significant relationship was observed between the two factors.
Ivanov
S D
SD
Central Research Institute of Roentgeno-Radiology, Ministry of Health of the RF, St. Petersburg.
Iamshanov
V A
VA
Korytova
L I
LI
Khazova
T V
TV
Arzumanov
A S
AS
D000328:Adult; D000368:Aged; D000963:Antimetabolites / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects*; D004002:Clodronic Acid / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006402:Hematologic Diseases / Q000139:chemically induced / Q000209:etiology*; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D011379:Prognosis; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects*
D000963:Antimetabolites; D004002:Clodronic Acid; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate