DDTC, a metabolite of disulfiram, reduces the stimulating effect on ethanol's locomotor activity in mice.
To investigate how diethyldithiocarbamate (DDTC) affects the stimulating effect of ethanol on open-field locomotion, mice were pretreated with different doses of DDTC 8 hours prior to ethanol. The effect of DDTC and saline on different ethanol doses was analyzed. DDTC reduces ethanol-induced locomotor activity in a dose-dependent manner, not the spontaneous locomotor activity. Aldehyde dehydrogenase might influence psychopharmacological effects of ethanol.
Escarabajal
Maria Dolores
MD
Area de Psicobiología, Departamento de Psicología, Universidad de Jeán, Paraje Las Lagunillas, Spain. descara@ujean.es
Aragon
Carlos M G
CM
D000427:Alcohol Deterrents / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D004221:Disulfiram / Q000493:pharmacokinetics / Q000494:pharmacology*; D004050:Ditiocarb / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*
D000427:Alcohol Deterrents; D002492:Central Nervous System Depressants; D000431:Ethanol; D004050:Ditiocarb; D004221:Disulfiram