Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction.
Structural features of two weak inhibitors of the ZipA-FtsZ protein-protein interaction which were found to bind to overlapping but different areas of the key binding site were combined in one new series of carboxybiphenyl-indoles with improved inhibitory activity.
Sutherland
Alan G
AG
Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA. sutherag@wyeth.com
Alvarez
Juan
J
Ding
Weidong
W
Foreman
K W
KW
Kenny
Cynthia Hess
CH
Labthavikul
Pornpen
P
Mosyak
Lidia
L
Petersen
Peter J
PJ
Rush
Thomas S
TS
Ruzin
Alexey
A
Tsao
Desiree H H
DH
Wheless
Karen L
KL
D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D015195:Drug Design; D029968:Escherichia coli Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D015394:Molecular Structure; D011485:Protein Binding / Q000187:drug effects; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
D001426:Bacterial Proteins; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; D029968:Escherichia coli Proteins; C071525:FtsZ protein, Bacteria; D007211:Indoles; C103795:ZipA protein, E coli; C030374:indole