Difference in mGluR5 interaction between positive allosteric modulators from two structural classes.
Williams
David L
DL
Department of Neuroscience-WP, Merck Research Laboratories, West Point, Pennsylvania and Rahway, New Jersey. david_williams1@merck.com
O'Brien
Julie A
JA
Lemaire
Wei
W
Chen
Tsing-Bau
TB
Chang
Raymond S L
RS
Jacobson
Marlene A
MA
Ha
Sookhee N
SN
Wisnoski
David D
DD
Lindsley
Craig W
CW
Sur
Cyrille
C
Duggan
Mark E
ME
Pettibone
Douglas J
DJ
Conn
P Jeffrey
PJ
D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D001665:Binding Sites; D016466:CHO Cells; D006224:Cricetinae; D018690:Excitatory Amino Acid Agonists / Q000737:chemistry / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000737:chemistry / Q000494:pharmacology*; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology; D010797:Phthalimides / Q000494:pharmacology; D051381:Rats; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000737:chemistry / Q000187:drug effects*; D012118:Resorcinols / Q000494:pharmacology; D013329:Structure-Activity Relationship
C481447:3,3'-difluorobenzaldazine; D001549:Benzamides; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; C578935:GRM5 protein, human; C578937:Grm5 protein, rat; D006834:Hydrazines; C481448:N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide; D010797:Phthalimides; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; D012118:Resorcinols; C079215:3,5-dihydroxyphenylglycine; D005998:Glycine