High resolution magic angle spinning NMR for analyzing small molecules attached to solid support.
Solid phase synthesis has become a routine technique in combinatorial chemistry. The need in analytical methods to characterize nondestructively resin bound molecules has been fulfilled by the introduction of High Resolution Magic Angle Spinning (HR MAS) NMR of solvent swollen beads. HR MAS NMR can give solution like proton NMR spectra and one- and two-dimensional NMR techniques are amenable, allowing detailed structure analysis. Recent developments are the application of a diffusion filter to suppress solvent signals and dipolar recoupling techniques to gain spatial information. HR MAS NMR has been applied to monitor reactions and elucidate reaction products.
Schröder
Harald
H
Aventis Combinatorial Technologies Center, Tucson, AZ 85737, USA. harald.schroeder@aventis.com
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008863:Microspheres; D009930:Organic Chemicals / Q000138:chemical synthesis
D009930:Organic Chemicals