Aminoacid profile and oxidative status in children affected by Down syndrome before and after supplementary nutritional treatment.
Down syndrome is the most common autosomal aberration among liveborns, characterised by several clinical features and metabolic disturbances. Aminoacid pathways abnormalities and defective oxidative balance are the most common metabolic problems in Down Syndrome. To evaluate the biochemical responses of children with Down Syndrome to a nutritional regimen supplemented with aminoacids, vitamins and polyunsaturated fatty acids, we submitted 86 subjects divided in two groups (0-6 and 6-12 years) to the dosage of plasma levels of aminoacids, antioxidant enzymes activities and reactive oxygen species, before and after 12 months of such nutritional supplementation and in relation to normal controls. The results obtained showed a tendency towards the values of normal subjects with statistically significant differences. Although other studies must be performed to confirm and define such report, our experience supports the usefulness of a nutritional supplementation with aminoacids, vitamins and polyunsaturated fatty acids, also considering the absence of side effects.
Ciaccio
Marcello
M
Cattedra di Biochimica Clinica, Facoltà di Medicina e Chirurgia, Sezione di Biochimica Medica, Dipartimento di Biotecnologie Mediche e Medicina Legale, Università degli Studi di Palermo, Palermo, Italy. marcello.ciaccio@unipa.it
Piccione
Maria
M
Giuffrè
Mario
M
Macaione
Vincenzo
V
Vocca
Lavinia
L
Bono
Antonino
A
Corsello
Giovanni
G
D000367:Age Factors; D000596:Amino Acids / Q000378:metabolism* / Q000494:pharmacology; D000975:Antioxidants / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D019587:Dietary Supplements; D004314:Down Syndrome / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D017382:Reactive Oxygen Species; D013997:Time Factors; D014527:Uric Acid / Q000097:blood; D014815:Vitamins / Q000378:metabolism
D000596:Amino Acids; D000975:Antioxidants; D005231:Fatty Acids, Unsaturated; D017382:Reactive Oxygen Species; D014815:Vitamins; D014527:Uric Acid; D010100:Oxygen