title: [Comparative study of three local ablation methods for transplanted hepatocellular carcinoma in mice].
abstract: OBJECTIVE
  To observe the effects of three commonly used local ablation methods in the treatment of transplanted hepatocellular carcinoma in mice to provide experimental evidence for treating hepatocellular carcinoma that defies surgical removal.
  
  
  METHODS
  Mouse models of hepatocellular carcinoma were established by means of subcutaneous transplantation, and treatment results of the three ablation methods, namely percutaneous ethanol injection therapy (PEIT), percutaneous acetic acid injection therapy (PAIT) and percutaneous local cryosurgery therapy (PLCT), were compared.
  
  
  RESULTS
  The tumor inhibition rates of PLCT, PAIT and PEIT were 99.2%, 85.3%, and 72.8%, respectively. The rates for complete necrosis of the tumors were 100% (5/5), 60% (3/5), and 40% (2/5), with the survival time of 88.11+/-5.67, 86.67+/-7.26, and 72.89+/-12.86 days respectively.
  
  
  CONCLUSIONS
  All of the three local ablation methods can inhibit the tumor growth to various degrees and prolong the survival time of the tumor-bearing mice. PLCT may yield relatively better result than the other two methods.
authors.affiliation: Department of Oncology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. duarion@sohu.com
authors.forename: Wei-liang
authors.initials: WL
authors.lastname: Zhu
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Ji-ren
authors.initials: JR
authors.lastname: Zhang
authors.forename: Sen-ming
authors.initials: SM
authors.lastname: Wang
authors.forename: Hai-ji
authors.initials: HJ
authors.lastname: Bu
mesh_terms: D019342:Acetic Acid / Q000008:administration & dosage*; D000279:Administration, Cutaneous; D000818:Animals; D003452:Cryosurgery; D000431:Ethanol / Q000008:administration & dosage*; D007267:Injections; D008114:Liver Neoplasms, Experimental / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation
chemical_list: D000431:Ethanol; D019342:Acetic Acid