Curvularia--favorable response to oral itraconazole therapy in two patients with locally invasive phaeohyphomycosis.
Curvularia species are ubiquitous and occasionally lead to infections in humans. In immunosuppressed patients, infections are often serious, and systemic dissemination is not uncommon. The optimal antifungal therapy is unclear. I here present two cases, a healthy man with locally invasive, mulicentric paranasal fungal sinusitis, and a case of progressive verrucal distal onychomycosis that developed while the patient was undergoing accelerated chemotherapy for non-Hodgkin's lymphoma. Both patients showed excellent responses to treatment with itraconazole suspension. Oral itraconazole may provide a safe and effective alternative for patients with locally invasive non-disseminated mycoses due to Curvularia species.
Safdar
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Department of Infectious Diseases, Infection Control and Employee Health, 402, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030-4095, USA. asafdar@mdanderson.org
D000284:Administration, Oral; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001203:Ascomycota / Q000254:growth & development*; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy*; D014009:Onychomycosis / Q000188:drug therapy / Q000382:microbiology; D012852:Sinusitis / Q000188:drug therapy / Q000382:microbiology
D000935:Antifungal Agents; D017964:Itraconazole