title: A comparison of hepatitis C treatment and outcomes at academic, private and Veterans' Affairs treatment centres.
abstract: BACKGROUND
  Currently, there is a lack of published data examining hepatitis C treatment practices in different care settings.
  
  
  OBJECTIVE
  To provide data describing treatment practices for patients with hepatitis C virus infection in actual clinical practice, and to examine clinical outcomes in patients treated with interferon alpha-2b/ribavirin combination therapy in academically affiliated centres, private treatment centres and Veterans' Affairs treatment centres.
  
  
  METHODS
  This multi-centre, retrospective, cohort study of 231 patients examined hepatitis C virus treatment practices in patients receiving interferon alpha-2b from January 1997 to May 2001 and explored outcomes in academically affiliated, private and Veterans' Affairs centres.
  
  
  RESULTS
  Differences in treatment practice and use of diagnostic procedures were found. Genotype testing was under-utilized in non-academic sites (academic centres, 79.2%; private centres, 33.7%; Veterans' Affairs centres, 35.9%; P<0.001). Liver biopsies were performed less often in private sites (academic centres, 95.8%; private centres, 80.0%; Veterans' Affairs centres, 92.2%; P<0.01). End-of-treatment viral response (academic centres, 40.0%; private centres, 31.3%; Veterans' Affairs centres, 17.2%; P<0.05) was lower than that found in published trial data. Multivariate analysis revealed genotype 1 as the single significant predictor of treatment failure (P<0.01).
  
  
  CONCLUSIONS
  Outside of the academic setting, there is significantly less diagnostic work-up performed prior to the initiation of hepatitis C virus therapy. This suggests a need for a standardization of care across treatment settings.
authors.affiliation: Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Jensen
authors.forename: S J
authors.initials: SJ
authors.lastname: Cotler
authors.forename: H
authors.initials: H
authors.lastname: Lam
authors.forename: G
authors.initials: G
authors.lastname: Harb
authors.forename: A
authors.initials: A
authors.lastname: Shillington
mesh_terms: D000046:Academic Medical Centers / Q000706:statistics & numerical data*; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use; D015331:Cohort Studies; D004338:Drug Combinations; D005260:Female; D006526:Hepatitis C / Q000188:drug therapy*; D006787:Hospitals, Veterans / Q000706:statistics & numerical data*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D017149:Private Sector / Q000706:statistics & numerical data*; D011994:Recombinant Proteins; D012189:Retrospective Studies; D012254:Ribavirin / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D004338:Drug Combinations; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D012254:Ribavirin