title: Anti-angiogenic and inhibitory activity on inducible nitric oxide production of the mushroom Ganoderma lucidum.
abstract: Fresh fruit bodies of Ganoderma lucidum were extracted with 70% ethanol at room temperature. The extract (GL) showed significant anti-angiogenic activity, which was detected using a chick embryo chorioallantoic membrane assay. GL significantly inhibited LPS-induced NO production in RAW 264.7 macrophages. These results support the anti-tumor effect of Ganoderma lucidum.
authors.affiliation: Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, PO Box 131, Seoul 130-650, South Korea.
authors.forename: Yun Seon
authors.initials: YS
authors.lastname: Song
authors.forename: Sun-Hyoung
authors.initials: SH
authors.lastname: Kim
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Sa
authors.forename: Changbae
authors.initials: C
authors.lastname: Jin
authors.forename: Chang-Jin
authors.initials: CJ
authors.lastname: Lim
authors.forename: Eun-Hee
authors.initials: EH
authors.lastname: Park
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D005638:Fruit; D066298:In Vitro Techniques; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D010936:Plant Extracts / Q000494:pharmacology; D020940:Reishi
chemical_list: D020533:Angiogenesis Inhibitors; D010936:Plant Extracts; D009569:Nitric Oxide