title: Hepatocellular carcinoma: regional therapy with a magnetic targeted carrier bound to doxorubicin in a dual MR imaging/ conventional angiography suite--initial experience with four patients.
abstract: Four patients with inoperable hepatocellular carcinoma were treated with a magnetic targeted carrier bound to doxorubicin (MTC-DOX) by using a joint magnetic resonance (MR) imaging/conventional angiography system consisting of a 1.5-T short-bore magnet connected to a C-arm angiography unit by a sliding tabletop. Selective transcatheter delivery of the MTC-DOX to the hepatic artery was monitored by using intraprocedural MR imaging, and interim catheter manipulation was performed with fluoroscopic guidance to optimize agent delivery to the tumor and minimize delivery to normal tissue. The final fraction of treated tumor volume ranged from 0.64 to 0.91. The fraction of affected normal liver volume ranged from 0.07 to 0.30. The dual MR imaging/conventional angiography system shows promise for directing magnetically targeted tumor therapies.
authors.affiliation: Departments of Radiology and Medicine, University of California, San Francisco, 505 Parnassus Avenue, Room M-361, San Francisco, CA 94143, USA. mark.wilson@radiology.ucsf.edu
authors.forename: Mark W
authors.initials: MW
authors.lastname: Wilson
authors.forename: Robert K
authors.initials: RK
authors.lastname: Kerlan
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Fidelman
authors.forename: Alan P
authors.initials: AP
authors.lastname: Venook
authors.forename: Jeanne M
authors.initials: JM
authors.lastname: LaBerge
authors.forename: Joy
authors.initials: J
authors.lastname: Koda
authors.forename: Roy L
authors.initials: RL
authors.lastname: Gordon
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D004317:Doxorubicin / Q000008:administration & dosage*; D004337:Drug Carriers; D004867:Equipment Design; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000295:instrumentation; D008280:Magnetics / Q000295:instrumentation; D008297:Male; D008875:Middle Aged
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D004317:Doxorubicin