title: Viral hepatitis in the Canadian Inuit and First Nations populations.
abstract: OBJECTIVE
  To review published prevalence data regarding hepatitis A (HAV), B (HBV) and C (HCV) in Canadian Inuit and First Nations populations.
  
  
  METHODS
  PubMed database search and review of all papers describing data derived from seroepidemiological surveys.
  
  
  RESULTS
  The prevalence of anti-HAV positivity in Canadian Inuit and First Nations populations reported to date is high (range 75% to 95%) and approximately three times that of non-Aboriginal Canadians residing in the same communities. Among the Canadian Inuit, the prevalence of HBV infection is approximately 5%, or 20 times that of non-Aboriginal Canadians, while the risk of exposure to HBV is 25%, or five times higher. Regarding the First Nations population, preliminary data suggest the prevalences of HBV infection (0.3% to 3%) and exposure (10% to 22%) are similar to rates in non-Aboriginals residing in the same regions and participating in similar high risk activities. Serological evidence of HCV infection (anti-HCV) is more common in the Canadian Inuit and First Nations (1% to 18%) than the remainder of the Canadian population (0.5% to 2%); however, viremia (HCV-RNA positivity) is less common (less than 5% versus 75% of anti-HCV positive individuals, respectively).
  
  
  CONCLUSIONS
  Viral hepatitis is common in the Canadian Inuit and First Nations populations. In the absence of coexisting human immunodeficiency virus infection and alcohol abuse, the outcomes of HBV and HCV appear to be more benign than in non-Aboriginal Canadians.
authors.affiliation: Department of Medicine, University of Manitoba, Winnipeg, Canada. gminuk@cc.umanitoba.ca
authors.forename: Gerald Y
authors.initials: GY
authors.lastname: Minuk
authors.forename: J
authors.initials: J
authors.lastname: Uhanova
mesh_terms: D000293:Adolescent; D000328:Adult; D002170:Canada; D002648:Child; D002675:Child, Preschool; D005260:Female; D006506:Hepatitis A / Q000453:epidemiology; D006509:Hepatitis B / Q000453:epidemiology; D006526:Hepatitis C / Q000453:epidemiology; D006525:Hepatitis, Viral, Human / Q000453:epidemiology*; D006801:Humans; D007198:Indians, North American; D007223:Infant; D008297:Male; D008875:Middle Aged