title: [Activity of the basic carboxypeptidases in female rat tissues at different stages of estrus cycle].
abstract: It is revealed, that the activity of neuropeptide metabolism enzymes (carboxypeptidase H, phenylmethylsulfonilfluorid-inhibited carboxypeptidase) in the female rat tissues depends upon the stage of estrus cycle. The carboxypeptidase H activity in the pituitary gland is the highest in proestrus; it is almost 3 times higher in comparison with diestrus; it is a little bit higher in striatum on the stage of estrus, than in diestrus and proestrus, in adrenals on the stage of proestrus and estrus it is a little bit lower, than in diestrus; in the ovaries on the stage of proestrus it is much higher, than in estrus and diestrus. The activity of PMSF-inhibited carboxypeptidase in ovaries on the stage of proestrus and diestrus is 1.7-1.8 times higher, than at the stage of diestrus. The activity of carboxypeptidase M in adrenal tissue at the stage of proestrus is 35-40% of that at the stage of diestrus and estrus. The activity of carboxypeptidase M in the ovaries at the stage of diestrus is 45-50% of that at the stage of diestrus and estrus. The role of the investigated enzymes in cyclic changes of a level of biologically active peptides and in regulation of estrus cycle is discussed.
authors.affiliation: Penza State Pedagogical University, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Vernigora
authors.forename: M T
authors.initials: MT
authors.lastname: Gengin
authors.forename: Zh S
authors.initials: ZhS
authors.lastname: Bardinova
authors.forename: V A
authors.initials: VA
authors.lastname: Smetanin
authors.forename: O P
authors.initials: OP
authors.lastname: Petrushova
mesh_terms: D000311:Adrenal Glands / Q000201:enzymology*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002268:Carboxypeptidases / Q000378:metabolism*; D003342:Corpus Striatum / Q000201:enzymology; D004971:Estrus / Q000378:metabolism* / Q000502:physiology; D005260:Female; D007031:Hypothalamus / Q000201:enzymology; D066298:In Vitro Techniques; D010053:Ovary / Q000201:enzymology*; D010902:Pituitary Gland / Q000201:enzymology; D051381:Rats
chemical_list: D002268:Carboxypeptidases