title: IntAct: an open source molecular interaction database.
abstract: IntAct provides an open source database and toolkit for the storage, presentation and analysis of protein interactions. The web interface provides both textual and graphical representations of protein interactions, and allows exploring interaction networks in the context of the GO annotations of the interacting proteins. A web service allows direct computational access to retrieve interaction networks in XML format. IntAct currently contains approximately 2200 binary and complex interactions imported from the literature and curated in collaboration with the Swiss-Prot team, making intensive use of controlled vocabularies to ensure data consistency. All IntAct software, data and controlled vocabularies are available at http://www.ebi.ac.uk/intact.
authors.affiliation: European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK. hhe@ebi.ac.uk
authors.forename: Henning
authors.initials: H
authors.lastname: Hermjakob
authors.forename: Luisa
authors.initials: L
authors.lastname: Montecchi-Palazzi
authors.forename: Chris
authors.initials: C
authors.lastname: Lewington
authors.forename: Sugath
authors.initials: S
authors.lastname: Mudali
authors.forename: Samuel
authors.initials: S
authors.lastname: Kerrien
authors.forename: Sandra
authors.initials: S
authors.lastname: Orchard
authors.forename: Martin
authors.initials: M
authors.lastname: Vingron
authors.forename: Bernd
authors.initials: B
authors.lastname: Roechert
authors.forename: Peter
authors.initials: P
authors.lastname: Roepstorff
authors.forename: Alfonso
authors.initials: A
authors.lastname: Valencia
authors.forename: Hanah
authors.initials: H
authors.lastname: Margalit
authors.forename: John
authors.initials: J
authors.lastname: Armstrong
authors.forename: Amos
authors.initials: A
authors.lastname: Bairoch
authors.forename: Gianni
authors.initials: G
authors.lastname: Cesareni
authors.forename: David
authors.initials: D
authors.lastname: Sherman
authors.forename: Rolf
authors.initials: R
authors.lastname: Apweiler
mesh_terms: D000818:Animals; D019295:Computational Biology; D030562:Databases, Protein; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D012984:Software; D014584:User-Computer Interface; D018875:Vocabulary, Controlled
chemical_list: D011506:Proteins