G-protein activation decreases the isoflurane inhibition of N-type Ca2+ currents. An increase in the isoflurane blocking potency of N-type Ca2+ currents may contribute to the known neuroprotection action of isoflurane during ischemia.
Recio-Pinto
Esperanza
E
Department of Anesthesiology, New York University Medical Center, New York, NY 10016, USA. recioe02@med.nyu.edu
Nikonorov
Igor M
IM
Blanck
Thomas J J
TJ
D018685:Anesthetics, Inhalation / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D020864:Calcium Channels, N-Type / Q000187:drug effects* / Q000378:metabolism; D002460:Cell Line; D018118:Chloride Channels / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D007511:Ischemia / Q000188:drug therapy*; D007530:Isoflurane / Q000494:pharmacology*; D008959:Models, Neurological; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018408:Patch-Clamp Techniques
D018685:Anesthetics, Inhalation; D002121:Calcium Channel Blockers; D020864:Calcium Channels, N-Type; D018118:Chloride Channels; D018696:Neuroprotective Agents; D007530:Isoflurane; D019204:GTP-Binding Proteins