Locally administered nerve growth factor suppresses ginsenoside Rb1-enhanced peripheral nerve regeneration.
A high-dose of nerve growth factor (NGF) mixed with ginsenoside Rb1 (GRb1) was encapsulated by collagen and placed in silicone rubber chambers, which were used to repair dissected Sprague-Dawley rat sciatic nerves with 15 mm gaps. Six weeks after surgery, no axons or Schwann cells were seen in these chambers. By comparison, nerves treated with collagen-GRb1 alone had regenerated axons and Schwann cells in their endoneurial areas. We suggest that excessive NGF may not promote but, rather, suppress developing nerves.
Tsai
Chin-Chuan
CC
School of Post Baccalaureate Chinese Medicine, China Medical University, Taichung, Taiwan. tsaicc@mail.cmc.edu.tw
Lu
Ming-Chin
MC
Chen
Yueh-Sheng
YS
Wu
Chun-Hsien
CH
Lin
Chun-Ching
CC
D000818:Animals; D004195:Disease Models, Animal; D036145:Ginsenosides / Q000494:pharmacology*; D008297:Male; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009416:Nerve Regeneration / Q000187:drug effects*; D005894:Panax; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000187:drug effects* / Q000293:injuries / Q000473:pathology / Q000503:physiopathology; D012826:Silicone Elastomers; D013997:Time Factors
D036145:Ginsenosides; D009414:Nerve Growth Factors; D012826:Silicone Elastomers; C442759:ginsenoside Rb1