title: Right ventricular adaptation to pulmonary hypertension: an interspecies comparison.
abstract: Right ventricular (RV) adaptation is an important prognostic factor in acute and chronic pulmonary hypertension. Pulmonary vascular basal tone and hypoxic reactivity are known to vary widely between species. We investigated how RV adaptation to acute pulmonary hypertension is preserved in species with low, intermediate, and high pulmonary vascular resistance and reactivity. Acute pulmonary hypertension was induced by hypoxia, distal embolism, and proximal constriction in anesthetized dogs (n = 10), goats (n = 8), and pigs (n = 8). Pulmonary vessels were assessed by flow-pressure curves and by impedance to quantify distal resistance, proximal elastance, and wave reflections. RV function was assessed by pressure-volume curves to quantify afterload, contractility, and ventricular-arterial coupling efficiency. First, hypoxia was associated with a progressive increase of resistance, elastance, and wave reflection from dogs to goats and from goats to pigs. RV contractility increased proportionally to RV afterload, and optimal coupling was preserved in all species. Second, embolism increased resistance and wave reflection but not elastance. The increase in RV contractility matched the increase in RV afterload and optimal coupling was preserved. Finally, proximal pulmonary artery constriction increased resistance, increased and accelerated wave reflection, and markedly increased elastance. RV contractility increased markedly and coupling showed a nonsignificant trend to decrease. We conclude that optimal or near-optimal ventricular-arterial coupling is maintained in acute pulmonary hypertension, whether in absence or presence of chronic species-induced pulmonary hypertension.
authors.affiliation: Laboratory of Physiology, Free University of Brussels, B-1070 Brussels, Belgium. pierre.wauthy@wanadoo.be
authors.forename: Pierre
authors.initials: P
authors.lastname: Wauthy
authors.forename: Alberto
authors.initials: A
authors.lastname: Pagnamenta
authors.forename: Fabio
authors.initials: F
authors.lastname: Vassalli
authors.forename: Robert
authors.initials: R
authors.lastname: Naeije
authors.forename: Serge
authors.initials: S
authors.lastname: Brimioulle
mesh_terms: D000818:Animals; D001158:Arteries / Q000503:physiopathology; D001794:Blood Pressure / Q000502:physiology; D003251:Constriction, Pathologic / Q000503:physiopathology; D004285:Dogs; D006041:Goats; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D009200:Myocardial Contraction / Q000502:physiology; D011652:Pulmonary Circulation / Q000502:physiology; D011655:Pulmonary Embolism / Q000503:physiopathology; D013045:Species Specificity; D013552:Swine; D014655:Vascular Resistance / Q000502:physiology; D016278:Ventricular Function, Right / Q000502:physiology*