title: Prevention of atrial fibrillation after cardiac valvular surgery by epicardial, biatrial synchronous pacing.
abstract: OBJECTIVE
  Postoperative atrial fibrillation (AF) after cardiac surgery is a frequent complication after valvular surgery (30-60%). The purpose of this prospective, randomized study was to determine if biatrial synchronous pacing reduces postoperative AF after cardiac valvular surgery as compared to conventional therapy.
  
  
  METHODS
  Eighty patients subjected to valvular surgery (52 men, age 66 +/- 10 years) were randomized to one of two groups: one group was treated with biatrial, synchronous pacing (BAP) for 72 h postoperatively (n=40) the other group received no atrial pacing (controls; n=40). All patients had one pair of epicardial wires attached to the right atrium. An additional electrode was placed to the left atrium in the BAP group. These patients were continuously paced at a rate of 10 beats per minute higher than the intrinsic rate starting immediately after surgery. All patients were monitored with full disclosure telemetry or Holter monitors to identify onset of AF.
  
  
  RESULTS
  Eighteen of the 40 patients in the control group (45%) developed AF within the first 3 days postoperatively as compared to eight patients (20%) in the BAP group (P=0.02). No complications occurred associated with the placement, maintenance and removal of the atrial pacing electrodes.
  
  
  CONCLUSIONS
  Temporary, biatrial synchronous pacing during the first 3 postoperative days is safe and has a significant rhythm-stabilizing effect in patients undergoing valvular cardiac surgery.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Stadtspital Triemli, CH-8063 Zurich, Switzerland. marianne.debrunner@triemli.stzh.ch
authors.forename: Marianne
authors.initials: M
authors.lastname: Debrunner
authors.forename: Barbara
authors.initials: B
authors.lastname: Naegeli
authors.forename: Michele
authors.initials: M
authors.lastname: Genoni
authors.forename: Marko
authors.initials: M
authors.lastname: Turina
authors.forename: Osmund
authors.initials: O
authors.lastname: Bertel
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000517:prevention & control*; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D004562:Electrocardiography; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery*; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D011379:Prognosis; D016019:Survival Analysis