[Effect of sildenafil ciltrate on the sexual activities of male rats].
OBJECTIVE
To obtain related pharmacodynamic data for the clinical experiment by observing the sexual activities of male rats after using sildenafil ciltrate through stomach irrigation.


METHODS
Forty male Sprague-Dawley rats were distributed into 4 groups with different dosages (control with distilled water, low dosage: 0.08%, medium dosage: 0.24% and high dosage: 0.72%). After the male Sprague-Dawlay rats were mated with their female counterparts in pairs, the latent period of chasing, the frequencies of chasing in 60 minutes, the latent period of intercourse and the frequencies of intercourse in 60 minutes were recorded.


RESULTS
Compared with the control, the frequencies of chasing were significantly increased and the latent periods of chasing were significantly shortened in both high dosage and medium dosage groups after using sildenafil (P < 0.01); The frequencies of intercourse in 60 minutes were significantly increased and the latent periods of intercourse were significantly shortened in all the groups after the use of sildenafil.


CONCLUSIONS
The sexual activities of male rats treated with sildenafil were significantly activated.
Huang
Xun-Bin
XB
Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei 430030, China.
Xiong
Cheng-Liang
CL
Shen
Ji-Yun
JY
Zhou
Jie-Ling
JL
Xiao
Hui-Zhu
HZ
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011687:Purines; D051381:Rats; D017207:Rats, Sprague-Dawley; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D000068677:Sildenafil Citrate; D013450:Sulfones
D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate