title: Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction.
abstract: Structural features of two weak inhibitors of the ZipA-FtsZ protein-protein interaction which were found to bind to overlapping but different areas of the key binding site were combined in one new series of carboxybiphenyl-indoles with improved inhibitory activity.
authors.affiliation: Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA. sutherag@wyeth.com
authors.forename: Alan G
authors.initials: AG
authors.lastname: Sutherland
authors.forename: Juan
authors.initials: J
authors.lastname: Alvarez
authors.forename: Weidong
authors.initials: W
authors.lastname: Ding
authors.forename: K W
authors.initials: KW
authors.lastname: Foreman
authors.forename: Cynthia Hess
authors.initials: CH
authors.lastname: Kenny
authors.forename: Pornpen
authors.initials: P
authors.lastname: Labthavikul
authors.forename: Lidia
authors.initials: L
authors.lastname: Mosyak
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Petersen
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Rush
authors.forename: Alexey
authors.initials: A
authors.lastname: Ruzin
authors.forename: Desiree H H
authors.initials: DH
authors.lastname: Tsao
authors.forename: Karen L
authors.initials: KL
authors.lastname: Wheless
mesh_terms: D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D002352:Carrier Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D003598:Cytoskeletal Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D015195:Drug Design; D029968:Escherichia coli Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D015394:Molecular Structure; D011485:Protein Binding / Q000187:drug effects; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; D029968:Escherichia coli Proteins; C071525:FtsZ protein, Bacteria; D007211:Indoles; C103795:ZipA protein, E coli; C030374:indole