title: Effects of recombinant human growth hormone and nandrolone phenylpropionate on the healing of ischemic colon anastomosis in rats.
abstract: OBJECTIVE
  Recombinant human growth hormone and nandrolone phenylpropionate are two different anabolic agents. This study was designed to investigate the effects of these anabolic agents on the healing of ischemic colon anastomosis in rats.
  
  
  METHODS
  Seventy adult male Wistar rats were divided into five groups (n = 14). Group I was the sham laparotomy group. In the other groups, surgical procedures consisting of transsection and anastomosis were made at a distance 3 cm from the peritoneal reflection. Group II was the nonischemic control group. Ischemic colon model was produced in the remaining groups. Group III was the untreated control group. Groups IV and V received recombinant human growth hormone and nandrolone phenylpropionate, respectively. Bursting pressure and hydroxyproline levels were measured on the third and seventh postoperative days to evaluate anastomotic healing.
  
  
  RESULTS
  Recombinant human growth hormone increased both collagen deposition and bursting pressure significantly at postoperative Days 3 and 7 compared with the sham and untreated control groups (P < 0.005). When compared with the untreated control, nandrolone phenylpropionate significantly increased collagen deposition at postoperative Days 3 and 7 (P < 0.005) and bursting pressure only at postoperative Day 3 (P < 0.005).
  
  
  CONCLUSIONS
  Recombinant human growth hormone has more favorable therapeutic effects on the healing of ischemic colonic anastomoses than nandrolone phenylpropionate. Recombinant human growth hormone also improves healing of nonischemic colonic anastomosis.
authors.affiliation: Department of General Surgery, SSK Hospital, Karamursel, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Yarimkaya
authors.forename: Berat
authors.initials: B
authors.lastname: Apaydin
authors.forename: Ethem
authors.initials: E
authors.lastname: Unal
authors.forename: Ilhan
authors.initials: I
authors.lastname: Karabicak
authors.forename: Fatih
authors.initials: F
authors.lastname: Aydogan
authors.forename: Ezel
authors.initials: E
authors.lastname: Uslu
authors.forename: Ethem
authors.initials: E
authors.lastname: Erginoz
authors.forename: Tarik
authors.initials: T
authors.lastname: Artis
authors.forename: Erhun
authors.initials: E
authors.lastname: Eyuboglu
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D003106:Colon / Q000098:blood supply / Q000601:surgery*; D004195:Disease Models, Animal; D019382:Human Growth Hormone / Q000494:pharmacology*; D007511:Ischemia / Q000209:etiology / Q000517:prevention & control; D008297:Male; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing
chemical_list: D019382:Human Growth Hormone; C015413:nandrolone acetate; D009277:Nandrolone