[The effect of periodontal initial therapy on circulating TNF-alpha and HbA1C in type 2 diabetes patients with periodontitis].
OBJECTIVE
To investigate the effect and mechanism of periodontal initial therapy on type 2 diabetes patients with periodontitis.


METHODS
15 type 2 diabetes patients with periodontitis were selected. Their body mass index (BMI), sulcus bleeding index (SBI), probing depth (PD), circulating tumor necrosis factor-alpha (TNF-alpha) concentration, and the value of glycosylated hemoglobin (HbA1C), triglycerides (TG) and cholesterol (CHOL) were assessed respectively before and 4-6 weeks after periodontal initial therapy.


RESULTS
After initial therapy, SBI, PD, circulating TNF-alpha concentration, and the value of HbA1C and TG were reduced significantly (P<0.05), while there were no significant differences in BMI and CHOL value (P>0.05).


CONCLUSIONS
Periodontal initial therapy can effectively reduce HbA1C value in type 2 diabetes patients with periodontitis, possibly through the reduction of circulating TNF-alpha concentration.
Yang
Pi-shan
PS
Department of Periodontology and Mucosal Diseases, College of Stomatology, Shandong University, Jinan 250012, China.
Wang
Yan
Y
Qi
Xiang-min
XM
Ren
Jian-min
JM
Ge
Shao-hua
SH
D000328:Adult; D000368:Aged; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000097:blood / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D006442:Glycated Hemoglobin; D008055:Lipids; D014409:Tumor Necrosis Factor-alpha