title: Clinical and radiographic evaluation of guided tissue regeneration in the treatment of class II furcation defects. A randomized clinical trial.
abstract: OBJECTIVE
  To evaluate the treatment outcomes after guided tissue regeneration (GTR) with a bioabsorbable membrane in Class II furcation defects in mandibular molars. The open flap debridement (OFD) was used as the control.
  
  
  METHODS
  Nine patients, with two comparable Class II furcation defects were included in the study. After initial preparation, the defects were randomly assigned in each patient to either GTR-group or OFD-group. Clinical parameters and standardized radiographs were obtained at baseline and 6 months after the surgeries. The radiographs were analyzed by subtraction radiography.
  
  
  RESULTS
  Comparing baseline to 6-month results, both groups showed statistically significant probing depth reduction (PD), horizontal clinical attachment level (CAL-h) gain, and increase in gingival recession (GR). The vertical clinical attachment level (CAL-v) gain was statistically significant only for the OFD-group. Comparing the two treatments, no statistically significant differences were found in PD reduction (GTR: 1.67 mm; OFD: 2.51 mm, P = 0.26), CAL-v gain (GTR: 0.62 mm; OFD: 1.16 mm, P= 0.37), and GR increase (GTR: 1.04 mm; OFD: 1.24 mm, P = 0.31). GTR provided complete closure of the furcation defect in two sites and superior horizontal clinical attachment level gain (GTR: 2.27 mm; OFD: 1.01 mm, P = 0.05). Subtraction radiography showed significant difference in bone height change between GTR-group and OFD-group (-0.14 mm and 0.86 mm, respectively; P = 0.028) at 6 months.
authors.affiliation: Dept. of Prosthodontics and Periodontics, Division of Periodontics, School of Dentistry at Piracicaba, University of Campinas, Piracicaba, SP, Brazil.
authors.forename: Patricia R
authors.initials: PR
authors.lastname: Cury
authors.forename: Marjorie K
authors.initials: MK
authors.lastname: Jeffcoat
authors.forename: Antônio W
authors.initials: AW
authors.lastname: Sallum
authors.forename: Raul
authors.initials: R
authors.lastname: Cafesse
authors.forename: Francisco H
authors.initials: FH
authors.lastname: Nociti Júnior
authors.forename: Enilson A
authors.initials: EA
authors.lastname: Sallum
mesh_terms: D020341:Absorbable Implants; D000539:Alveolar Process / Q000000981:diagnostic imaging; D001672:Biocompatible Materials; D002951:Citrates; D003646:Debridement; D005260:Female; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000145:classification / Q000000981:diagnostic imaging / Q000601:surgery*; D005889:Gingival Recession / Q000145:classification / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000145:classification / Q000601:surgery; D010514:Periodontal Pocket / Q000145:classification / Q000601:surgery; D011091:Polyesters; D011859:Radiography; D013382:Subtraction Technique; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials; D002951:Citrates; C105021:Guidor; D008567:Membranes, Artificial; D011091:Polyesters