title: The effect of Cyclosporine A chronic administration on the antioxidant pattern of rat liver mitochondria: structural and functional consequences.
abstract: Cyclosporine A (CsA) plays a pivotal role in controlling Ca2+ movement in the cell modulating also the mitochondrial permeability transition pore. We investigated if chronic administration of CsA may have some effects on the lipophilic and hydrophilic antioxidant pattern of rat liver mitochondria and on their morphological structure. It seems that CsA administration does not statistically affect the redox status of the antioxidants investigated and their amounts (vitamin E, CoQ9, CoQ10, glutathione, uric acid and ascorbic acid) despite the variety of effects that this treatment produces at physiological and morphological levels. However, some kind of derangement could occur in the liver biochemical machinery since CsA treatment induces a markedly increased variability in antioxidant contents.
authors.affiliation: Intitute of Biochemistry, Universitá Politecnica delle Marche, Ancona, Italy. mbattino@unian.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Battino
authors.forename: Stefano
authors.initials: S
authors.lastname: Bompadre
authors.forename: Luciana
authors.initials: L
authors.lastname: Leone
authors.forename: Armanda
authors.initials: A
authors.lastname: Pugnaloni
authors.forename: Corrado
authors.initials: C
authors.lastname: Rubini
authors.forename: Maria Soledad
authors.initials: MS
authors.lastname: Ferreiro
authors.forename: Isabel
authors.initials: I
authors.lastname: Gallardo
authors.forename: Pedro
authors.initials: P
authors.lastname: Bullon
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D001205:Ascorbic Acid / Q000032:analysis; D003067:Coenzymes; D016572:Cyclosporine / Q000008:administration & dosage* / Q000009:adverse effects; D005978:Glutathione / Q000032:analysis; D008297:Male; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000737:chemistry* / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000032:analysis; D014527:Uric Acid / Q000032:analysis; D014810:Vitamin E / Q000032:analysis
chemical_list: D000975:Antioxidants; D003067:Coenzymes; D014451:Ubiquinone; D014810:Vitamin E; D014527:Uric Acid; D016572:Cyclosporine; C024989:coenzyme Q10; D005978:Glutathione; C030571:ubiquinone 9; D001205:Ascorbic Acid