Effect of polychlorinated biphenyls on spermatogenesis and testosterone secretion in adult cocks.
The effects of polychlorinated biphenyls (PCBs) on reproduction of adult cocks were studied by gavaging peanut oil or PCBs (Aroclor 1254, 50 mg/kg) once a week for six consecutive weeks. Physiological parameters were recorded and gonads were removed at the end of experiment for histological examination. The results showed that there was no significant difference between the control and treatment group in body weight, respiration rate, heart rate, body temperature, and the numbers of red and white blood cells. However, there was a marked decrease in the testicular weight and serum testosterone level after PCB treatment. Morphological studies manifested severe damage of the seminiferous tubules by PCB. The number of the germ cells at the different developmental stages was decreased and condensed nuclei were observed in most of these cells. This study revealed that the reproductive function of the adult cocks is sensitive to PCBs, which inhibited mainly spermatogenesis and testosterone secretion.
Zhang
Cai-qiao
CQ
College of Animal Sciences, Zhejiang University, Hangzhou 310029, China. cqzhang@zju.edu.cn
Qiao
Hui-li
HL
D000284:Administration, Oral; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002645:Chickens; D004785:Environmental Pollutants / Q000633:toxicity; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011078:Polychlorinated Biphenyls / Q000008:administration & dosage / Q000633:toxicity*; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects* / Q000254:growth & development / Q000473:pathology*; D013739:Testosterone / Q000097:blood*
D004785:Environmental Pollutants; D013739:Testosterone; D011078:Polychlorinated Biphenyls