title: Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography.
abstract: We derive conditions for the unique and simultaneous recovery of chromophore concentrations and scattering coefficients in multispectral continuous-wave diffuse optical tomography. These conditions depend strongly on measurement wavelengths. We introduce and demonstrate a general methodology for choosing those wavelengths, which yields superior separation of scattering from absorption and superior separation of one chromophore from another. Application of these concepts should significantly improve the fidelity of continuous-wave diffuse near-infrared optical tomography in tissues.
authors.affiliation: Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. corlua@dept.physics.upenn.edu
authors.forename: Alper
authors.initials: A
authors.lastname: Corlu
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
authors.forename: Regine
authors.initials: R
authors.lastname: Choe
authors.forename: Martin
authors.initials: M
authors.lastname: Schweiger
authors.forename: Elizabeth M C
authors.initials: EM
authors.lastname: Hillman
authors.forename: Simon R
authors.initials: SR
authors.lastname: Arridge
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh
mesh_terms: D003198:Computer Simulation; D006454:Hemoglobins; D007091:Image Processing, Computer-Assisted; D008962:Models, Theoretical; D010108:Oxyhemoglobins; D017785:Photons; D012542:Scattering, Radiation; D041622:Tomography, Optical; D014867:Water
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; D014867:Water; C100003:deoxyhemoglobin