Vaccinia virus recombinant expressing gene of tick-borne encephalitis virus non-structural NS1 protein elicits protective activity in mice.
A vaccinia virus recombinant containing the non-structural tick-borne encephalitis virus (TBEV) NS1 gene was developed. The recombinant expressed native dimeric form of the NS1 protein in infected cells and protected mice against lethal infection with TBEV.
Khoretonenko
M V
MV
Chumakov Institute of Poliomyelitis and Viral Encephalitides RAMS, Moscow, Russia.
Vorovitch
M F
MF
Zakharova
L G
LG
Pashvykina
G V
GV
Ovsyannikova
N V
NV
Stephenson
J R
JR
Timofeev
A V
AV
Altstein
A D
AD
Shneider
A M
AM
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D002460:Cell Line; D004669:Encephalitis Viruses, Tick-Borne / Q000235:genetics / Q000276:immunology*; D004675:Encephalitis, Tick-Borne / Q000276:immunology* / Q000517:prevention & control* / Q000821:virology; D051379:Mice; D008807:Mice, Inbred BALB C; D015531:Radioimmunoprecipitation Assay; D015996:Survival Rate; D014616:Vaccinia virus / Q000235:genetics*; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology
D000914:Antibodies, Viral; C100315:NS1 protein, Flavivirus; D017361:Viral Nonstructural Proteins; D014765:Viral Vaccines