Relationship between fluoroquinolone use and changes in susceptibility to fluoroquinolones of selected pathogens in 10 United States teaching hospitals, 1991-2000.
We retrospectively examined the relationship between fluoroquinolone use and the susceptibilities of 11 bacterial pathogens to fluoroquinolones in 10 US teaching hospitals from 1991 through 2000. Statistical significance was determined by 2-way analysis of variance, with the number of isolates tested each year as a weighting factor. The analysis of baseline-to-end point change in the percentage of susceptibility and the slope of the regression line (trend line) for logit percentage of susceptibility showed that the overall percentage of susceptibility to fluoroquinolones decreased significantly during the study period (P<.05) and that change in percentage of susceptibility was significantly related to change in fluoroquinolone use (P<.05). Particularly notable were the decreases in the susceptibilities of Pseudomonas aeruginosa, Proteus mirabilis, and Escherichia coli (decreases of 25.1%, 11.9%, and 6.8%, respectively).
Zervos
Marcus J
MJ
William Beaumont Hospital, Royal Oak, Michigan 48073, USA. mzervos@beaumont.edu
Hershberger
Ellie
E
Nicolau
David P
DP
Ritchie
David J
DJ
Blackner
Lori K
LK
Coyle
Elizabeth A
EA
Donnelly
Andrew J
AJ
Eckel
Stephen F
SF
Eng
Robert H K
RH
Hiltz
Alexandra
A
Kuyumjian
Arpi G
AG
Krebs
William
W
McDaniel
Angee
A
Hogan
Patricia
P
Lubowski
Teresa J
TJ
D000890:Anti-Infective Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004363:Drug Utilization; D004926:Escherichia coli / Q000187:drug effects*; D024841:Fluoroquinolones / Q000494:pharmacology*; D006784:Hospitals, Teaching; D006801:Humans; D008826:Microbial Sensitivity Tests; D011513:Proteus mirabilis / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012189:Retrospective Studies; D014481:United States
D000890:Anti-Infective Agents; D024841:Fluoroquinolones