Single stranded DNA translocation through a nanopore: a master equation approach.
We study voltage driven translocation of a single stranded DNA through a membrane channel. Our model, based on a master equation approach, investigates the probability density function of the translocation times, and shows that it can be either double peaked or mono peaked, depending on the system parameters. We show that the most probable translocation time is proportional to the polymer length, and inversely proportional to the first or second power of the voltage, depending on the initial conditions. The model recovers experimental observations on hetropolymers when using their properties inside the pore, such as stiffness and polymer-pore interaction.
Flomenbom
O
O
School of Chemistry, Raymond & Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel.
Klafter
J
J
D001482:Base Composition; D001483:Base Sequence; D001693:Biological Transport, Active / Q000502:physiology; D002462:Cell Membrane / Q000737:chemistry* / Q000502:physiology / Q000528:radiation effects*; D002463:Cell Membrane Permeability / Q000502:physiology / Q000528:radiation effects*; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004058:Diffusion; D004563:Electrochemistry / Q000379:methods; D004574:Electromagnetic Fields; D018274:Electroporation / Q000379:methods*; D008564:Membrane Potentials / Q000502:physiology / Q000528:radiation effects; D008954:Models, Biological; D008956:Models, Chemical; D015233:Models, Statistical; D008969:Molecular Sequence Data; D036103:Nanotechnology / Q000379:methods*; D016062:Porosity / Q000528:radiation effects; D055672:Static Electricity
D004247:DNA