title: Antidiarrhoeal activity of Rhus javanica ripen fruit extract in albino mice.
abstract: The antidiarrhoeal effects of the methanolic extract of Rhus javanica ripen fruits (MERJ) were investigated by employing four experimental models of diarrhoea in Swiss albino mice. MERJ treated mice, showed significant reduction in the faecal output and protected them from castor oil-induced diarrhoea. The extract also reduced the intestinal fluid secretion induced by MgSO4 and gastrointestinal motility after charcoal meal administration in the albino mice. No mortality and visible signs of general weakness was observed in the mice following the test extract administration up to 2000 mg/kg dose.
authors.affiliation: Department of Zoology, North-Eastern Hill University, Shillong 793 022, India.
authors.forename: Vareishang
authors.initials: V
authors.lastname: Tangpu
authors.forename: Arun K
authors.initials: AK
authors.lastname: Yadav
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000930:Antidiarrheals / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002368:Castor Oil; D003967:Diarrhea / Q000139:chemically induced / Q000517:prevention & control; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005638:Fruit; D005769:Gastrointestinal Motility / Q000187:drug effects*; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D029045:Rhus
chemical_list: D000930:Antidiarrheals; D010936:Plant Extracts; D002368:Castor Oil