title: Solid-phase synthesis and characterization of a novel fullerene-peptide derived from histone H3.
abstract: A peptide analogue from a histone H3 protein containing the L-fulleropyrrolidino-glutamic acid has been prepared by a solid-phase approach and has been fully characterized. By molecular modelling it was verified that this peptide derivative is able to retain a binding capacity to the MHC (major histocompatibility complex) molecule similar to that of the cognate epitope.
authors.affiliation: Institute of Molecular and Cellular Biology, UPR 9021 CNRS, 67084 Strasbourg, France. A.Bianco@ibmc.u-strasbg.fr
authors.forename: Alberto
authors.initials: A
authors.lastname: Bianco
authors.forename: Davide
authors.initials: D
authors.lastname: Pantarotto
authors.forename: Johan
authors.initials: J
authors.lastname: Hoebeke
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Briand
authors.forename: Maurizio
authors.initials: M
authors.lastname: Prato
mesh_terms: D002851:Chromatography, High Pressure Liquid; D000939:Epitopes / Q000737:chemistry / Q000276:immunology; D037741:Fullerenes / Q000737:chemistry*; D018698:Glutamic Acid / Q000737:chemistry; D006657:Histones / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000276:immunology; D017434:Protein Structure, Tertiary
chemical_list: D000939:Epitopes; D037741:Fullerenes; D006657:Histones; D010455:Peptides; D018698:Glutamic Acid