Central angiotensin II increases biosynthesis of tyrosine hydroxylase in the rat adrenal medulla.
Angiotensin II acting centrally contributes to the regulation of blood pressure and water intake and stimulates the release of catecholamines from the adrenal medulla. We hypothesized that the central angiotensin II is one mediator of biosynthesis of catecholamines in the adrenal medulla. Rats were administered i.c.v. angiotensin II or saline, and TH mRNA and protein levels in adrenal medulla were measured 1 or 3 h later. Angiotensin II did not change TH mRNA or protein 1 h later. However, by 3 h, angiotensin II increased TH mRNA and protein levels. Centrally administered angiotensin II elevates TH mRNA expression and protein levels in the adrenal medulla. In conclusion, one component of central angiotensin II elevation of blood pressure may be the result of increased catecholamine synthesis in the adrenal gland and elevated TH synthesis represents one underlying mechanism.
Dogan
M Devrim
MD
Department of Pharmacology, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Sumners
Colin
C
Broxson
Christopher S
CS
Clark
Nadia
N
Tümer
Nihal
N
D000313:Adrenal Medulla / Q000378:metabolism*; D000804:Angiotensin II / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure; D004299:Dopamine beta-Hydroxylase / Q000378:metabolism; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014446:Tyrosine 3-Monooxygenase / Q000096:biosynthesis*
D009478:Neuropeptide Y; D012333:RNA, Messenger; D000804:Angiotensin II; D014446:Tyrosine 3-Monooxygenase; D004299:Dopamine beta-Hydroxylase