The Pfam protein families database.
Pfam is a large collection of protein families and domains. Over the past 2 years the number of families in Pfam has doubled and now stands at 6190 (version 10.0). Methodology improvements for searching the Pfam collection locally as well as via the web are described. Other recent innovations include modelling of discontinuous domains allowing Pfam domain definitions to be closer to those found in structure databases. Pfam is available on the web in the UK (http://www.sanger.ac.uk/Software/Pfam/), the USA (http://pfam.wustl.edu/), France (http://pfam.jouy.inra.fr/) and Sweden (http://Pfam.cgb.ki.se/).
Bateman
Alex
A
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK. agb@sanger.ac.uk
Coin
Lachlan
L
Durbin
Richard
R
Finn
Robert D
RD
Hollich
Volker
V
Griffiths-Jones
Sam
S
Khanna
Ajay
A
Marshall
Mhairi
M
Moxon
Simon
S
Sonnhammer
Erik L L
EL
Studholme
David J
DJ
Yeats
Corin
C
Eddy
Sean R
SR
D000818:Animals; D019295:Computational Biology; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D008958:Models, Molecular; D005810:Multigene Family; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000145:classification*
D011506:Proteins