Chlamydia-infected cells continue to undergo mitosis and resist induction of apoptosis.
Both anti- and proapoptotic activities have been reported to occur during chlamydial infection. To reconcile the apparent controversy, we compared host cell apoptotic responses to infection with 17 different chlamydial serovars and strains. None of the serovars caused any biologically significant apoptosis in the infected host cells. Host cells in chlamydia-infected cultures can continue to undergo DNA synthesis and mitosis. Chlamydia-infected cells are resistant to apoptosis induction, although the extent of the antiapoptotic ability varied between serovars. These observations have demonstrated that an anti- but not proapoptotic activity is the prevailing event in chlamydia-infected cultures.
Greene
Whitney
W
Department of Microbiology and Immunology. University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA.
Xiao
Yangming
Y
Huang
Yanqing
Y
McClarty
Grant
G
Zhong
Guangming
G
D017209:Apoptosis; D002478:Cells, Cultured; D002689:Chlamydia / Q000145:classification / Q000472:pathogenicity* / Q000502:physiology*; D004247:DNA / Q000096:biosynthesis; D006367:HeLa Cells; D006801:Humans; D008938:Mitosis
D004247:DNA