The interaction of daunorubicin and mitoxantrone with the red blood cells of acute myeloid leukemia patients.
The effect of DNR and MIT on erythrocyte membrane structure was examined using Electron Spin Resonance spectroscopy and the fluorimetric technique. The results suggest that the in vivo interaction of the drugs with the RBCs of AML patients led to a perturbation in the structure of plasma membrane components. Differences between DNR and MIT were only noted in the interaction of the drugs with deeper regions of the lipid bilayer
Marczak
Agnieszka
A
Department of Thermobiology, University of Łódź, Banacha 12/16, 90-237 Łódź, Poland. aszwar@biol.uni.lodz.pl
Wrzesień-Kuś
Agata
A
Krykowski
Euzebiusz
E
Robak
Tadeusz
T
Júźwiak
Zofia
Z
D000208:Acute Disease; D000328:Adult; D000368:Aged; D003630:Daunorubicin / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000473:pathology*; D004912:Erythrocytes / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy / Q000503:physiopathology*; D008051:Lipid Bilayers / Q000737:chemistry; D008560:Membrane Fluidity / Q000187:drug effects; D008875:Middle Aged; D008942:Mitoxantrone / Q000494:pharmacology*
D008051:Lipid Bilayers; D008942:Mitoxantrone; D003630:Daunorubicin