[Clinical and hemodynamical efficacy of prestarium and its role in the treatment of chronic pulmonary heart].
OBJECTIVE
To assess clinical efficiency and safety of ACE inhibitor prestarium (Servier, France) with specification of its effects on central and pulmonary hemodynamics, hepatic blood flow, indications in patients with chronic pulmonary heart (CPH).


METHODS
42 patients with chronic obstructive bronchitis (COB) complicated by CPH entered the trial. The patients were divided into two groups. Group 1 (n = 26) received standard therapy plus prestarium (2-4 mg/day), group 2 (n = 16) received only standard combined therapy. The examinees have undergone ultrasonic investigation of the heart and liver in Doppler modes, ECG monitoring, examination for external respiration function, lipid peroxidation activity, antioxidant blood defense.


RESULTS
Group 1 demonstrated earlier positive response. It was found that improvement in functional class of cardiac failure induced by prestarium and less frequent episodes of arrhythmia directly correlated. Positive changes were stated in central and hepatic hemodynamics, systolic pressure in the pulmonary artery lowered more significantly than in the control group.


CONCLUSIONS
If COB patients have symptoms of right ventricular failure, they are recommended to take prestarium in a daily dose 0.004 g for 4 weeks to improve intracardiac and hepatic hemodynamics, reduce systolic pressure in the pulmonary artery and number of prognostically unfavourable arrhythmic episodes.
Korneĭchuk
N N
NN
Butorov
I V
IV
Verbitskiĭ
O N
ON
Butorova
V G
VG
Paraska
V I
VI
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D029481:Bronchitis, Chronic / Q000150:complications* / Q000503:physiopathology; D016022:Case-Control Studies; D002908:Chronic Disease; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D020913:Perindopril / Q000627:therapeutic use*; D011660:Pulmonary Heart Disease / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D020913:Perindopril