title: Hydroxyurea-induced pneumonitis in a patient with chronic idiopathic myelofibrosis after prolonged drug exposure.
abstract: We describe a 63-yr-old patient diagnosed with chronic idiopathic myelofibrosis whose disease was treated with hydroxyurea for 2 yr. He developed respiratory symptoms that were extensively investigated including lung biopsy. Clinical, radiological and histological features were compatible with a diagnosis of hydroxyurea-induced pneumonitis. Following drug withdrawal there was remarkable improvement in clinical and radiological findings.
authors.affiliation: Department of Haematology, The Whittington Hospital, London, UK. c.wong@zen.co.uk
authors.forename: Chi C
authors.initials: CC
authors.lastname: Wong
authors.forename: David
authors.initials: D
authors.lastname: Brown
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Howling
authors.forename: Norman E
authors.initials: NE
authors.lastname: Parker
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced* / Q000175:diagnosis; D055728:Primary Myelofibrosis / Q000150:complications / Q000188:drug therapy*
chemical_list: D006918:Hydroxyurea