The effect of Cyclosporine A chronic administration on the antioxidant pattern of rat liver mitochondria: structural and functional consequences.
Cyclosporine A (CsA) plays a pivotal role in controlling Ca2+ movement in the cell modulating also the mitochondrial permeability transition pore. We investigated if chronic administration of CsA may have some effects on the lipophilic and hydrophilic antioxidant pattern of rat liver mitochondria and on their morphological structure. It seems that CsA administration does not statistically affect the redox status of the antioxidants investigated and their amounts (vitamin E, CoQ9, CoQ10, glutathione, uric acid and ascorbic acid) despite the variety of effects that this treatment produces at physiological and morphological levels. However, some kind of derangement could occur in the liver biochemical machinery since CsA treatment induces a markedly increased variability in antioxidant contents.
Battino
Maurizio
M
Intitute of Biochemistry, Universitá Politecnica delle Marche, Ancona, Italy. mbattino@unian.it
Bompadre
Stefano
S
Leone
Luciana
L
Pugnaloni
Armanda
A
Rubini
Corrado
C
Ferreiro
Maria Soledad
MS
Gallardo
Isabel
I
Bullon
Pedro
P
D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D001205:Ascorbic Acid / Q000032:analysis; D003067:Coenzymes; D016572:Cyclosporine / Q000008:administration & dosage* / Q000009:adverse effects; D005978:Glutathione / Q000032:analysis; D008297:Male; D008854:Microscopy, Electron; D008930:Mitochondria, Liver / Q000737:chemistry* / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000032:analysis; D014527:Uric Acid / Q000032:analysis; D014810:Vitamin E / Q000032:analysis
D000975:Antioxidants; D003067:Coenzymes; D014451:Ubiquinone; D014810:Vitamin E; D014527:Uric Acid; D016572:Cyclosporine; C024989:coenzyme Q10; D005978:Glutathione; C030571:ubiquinone 9; D001205:Ascorbic Acid