title: Pathbase: a database of mutant mouse pathology.
abstract: Pathbase is a database that stores images of the abnormal histology associated with spontaneous and induced mutations of both embryonic and adult mice including those produced by transgenesis, targeted mutagenesis and chemical mutagenesis. Images of normal mouse histology and strain-dependent background lesions are also available. The database and the images are publicly accessible (http://www.pathbase.net) and linked by anatomical site, gene and other identifiers to relevant databases; there are also facilities for public comment and record annotation. The database is structured around a novel ontology of mouse disorders (MPATH) and provides high-resolution downloadable images of normal and diseased tissues that are searchable through orthogonal ontologies for pathology, developmental stage, anatomy and gene attributes (GO terms), together with controlled vocabularies for type of genetic manipulation or mutation, genotype and free text annotation for mouse strain and additional attributes. The database is actively curated and data records assessed by pathologists in the Pathbase Consortium before publication. The database interface is designed to have optimal browser and platform compatibility and to interact directly with other web-based mouse genetic resources.
authors.affiliation: Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK. ps@mole.bio.cam.ac.uk
authors.forename: Paul N
authors.initials: PN
authors.lastname: Schofield
authors.forename: Jonathan B L
authors.initials: JB
authors.lastname: Bard
authors.forename: Catherine
authors.initials: C
authors.lastname: Booth
authors.forename: Jacques
authors.initials: J
authors.lastname: Boniver
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Covelli
authors.forename: Philippe
authors.initials: P
authors.lastname: Delvenne
authors.forename: Michele
authors.initials: M
authors.lastname: Ellender
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Engstrom
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Goessner
authors.forename: Michael
authors.initials: M
authors.lastname: Gruenberger
authors.forename: Heinz
authors.initials: H
authors.lastname: Hoefler
authors.forename: John
authors.initials: J
authors.lastname: Hopewell
authors.forename: Mariatheresa
authors.initials: M
authors.lastname: Mancuso
authors.forename: Carmel
authors.initials: C
authors.lastname: Mothersill
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Potten
authors.forename: Leticia
authors.initials: L
authors.lastname: Quintanilla-Fend
authors.forename: Bjorn
authors.initials: B
authors.lastname: Rozell
authors.forename: Hannu
authors.initials: H
authors.lastname: Sariola
authors.forename: John P
authors.initials: JP
authors.lastname: Sundberg
authors.forename: Andrew
authors.initials: A
authors.lastname: Ward
mesh_terms: D000818:Animals; D019295:Computational Biology; D016208:Databases, Factual; D004194:Disease; D005838:Genotype; D016247:Information Storage and Retrieval; D020407:Internet; D051379:Mice; D009154:Mutation; D010336:Pathology; D010641:Phenotype; D018875:Vocabulary, Controlled