[The state of hemodynamics and microcirculation in patients with hypertensive disease during long term controlled therapy with lisinopril].
Lisinopril (Diroton, 10-40 mg/day) was given for 6 months to 30 patients (mean age 57.2+/-0.64 years) with stage II hypertension (WHO, 1999). Left ventricular diastolic function and microcirculation were assessed by echocardiography and biomicroscopy, respectively. Treatment with lisinopril was associated with improvements of impaired left ventricular diastolic function, structural and functional state of the heart. Parameters of microcirculatory vascular bed also improved.
Markova
L I
LI
Moscow State Medical Dental University; ul. Delegatskaya 20, 103473 Moscow, Russia.
Kuznetsova
I V
IV
Korenkov
V V
VV
Arkad'eva
G V
GV
Radzevich
A E
AE
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use*; D001921:Brain / Q000098:blood supply*; D004452:Echocardiography / Q000379:methods; D005260:Female; D006352:Heart Ventricles / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D017706:Lisinopril / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D012720:Severity of Illness Index
D000806:Angiotensin-Converting Enzyme Inhibitors; D017706:Lisinopril