title: Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do.
abstract: The semicarbazide-sensitive amine oxidases (SSAO) (EC 1.4.3.6) were believed to be detoxifying enzymes, primarily involved in the oxidative deamination of endogenous amines, such as methylamine and aminoacetone, together with some xenobiotic amines. However, it appears that the reaction products may have important signalling functions in the regulation of cell development and glucose homeostasis. Furthermore, enzyme, from some sources, behaves as a cellular adhesion protein under inflammatory and it may also be involved in lipid transport. This review considers what is known about the activities and potential functions of this hardworking protein.
authors.affiliation: Department of Biochemistry, Trinity College, Dublin 2, Ireland.
authors.forename: Jeff
authors.initials: J
authors.lastname: O'Sullivan
authors.forename: Mercedes
authors.initials: M
authors.lastname: Unzeta
authors.forename: Joe
authors.initials: J
authors.lastname: Healy
authors.forename: Michael I
authors.initials: MI
authors.lastname: O'Sullivan
authors.forename: Gavin
authors.initials: G
authors.lastname: Davey
authors.forename: Keith F
authors.initials: KF
authors.lastname: Tipton
mesh_terms: D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism*; D000818:Animals; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D013379:Substrate Specificity / Q000502:physiology; D015262:Xenobiotics / Q000378:metabolism / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D015262:Xenobiotics; D006631:Amine Oxidase (Copper-Containing)