title: Differential modulation of the antifungal activity of amphotericin B by natural and ent-cholesterol.
abstract: The addition of exogenous ent-cholesterol suppressed the antifungal activity of the amphotericin B when added to cultures of Candida albicans, but to a lesser extent than natural cholesterol. There were no detectable differences between added 2a or 2b on the antifungal activities of jaspamide or bengazole A, two unrelated antifungal natural products.
authors.affiliation: Department of Chemistry, University of California, Davis, CA 95616, USA.
authors.forename: Rowena K
authors.initials: RK
authors.lastname: Richter
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Mickus
authors.forename: Scott D
authors.initials: SD
authors.lastname: Rychnovsky
authors.forename: Tadeusz F
authors.initials: TF
authors.lastname: Molinski
mesh_terms: D000666:Amphotericin B / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D002784:Cholesterol / Q000737:chemistry* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D013237:Stereoisomerism
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D002784:Cholesterol