Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria.
A series of ester and carbonate derivatives of the glycopeptide mannopeptimycin alpha (1) with potent activity against G+ bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci, was synthesized. The SAR data obtained from natural and semisynthetic compounds demonstrated the importance of a hydrophobic group in the terminal mannosyl moiety for antibacterial activity.
He
Haiyin
H
Department of Natural Products Chemistry, Chemical Sciences, Wyeth, Pearl River, NY 10965, USA. heh@wyeth.com
Shen
Bo
B
Petersen
Peter J
PJ
Weiss
William J
WJ
Yang
Hui Y
HY
Wang
Ting-Zhong
TZ
Dushin
Russell G
RG
Koehn
Frank E
FE
Carter
Guy T
GT
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002254:Carbonates / Q000737:chemistry* / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects* / Q000502:physiology; D004952:Esters; D006020:Glycopeptides; D051379:Mice; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
D000900:Anti-Bacterial Agents; D002254:Carbonates; D004952:Esters; D006020:Glycopeptides; C478082:mannopeptimycin