title: Fatality related to a 30-g venlafaxine overdose.
abstract: A 30-g venlafaxine overdose resulted in death for a 39-year-old woman whose 43-day clinical course was highlighted by refractory hypotension and the resulting complications of bowel ischemia and perforation. Her venlafaxine and O-desmethylvenlafaxine levels, analyzed by high-performance liquid chromatography one day after ingestion, were 21.82 mg/L (therapeutic range 0.1-0.5 mg/L) and 3.33 mg/L (0.2-0.4 mg/L), respectively. These levels remained elevated for over 7 days. Postulated explanations for these extended elevated levels were saturation of drug metabolism, decreased drug metabolism, and existence of a genetic polymorphism. Our patient's venlafaxine overdose produced a wide variety of clinical challenges, to include seizures, tachycardia, decreased level of consciousness, refractory hypotension, and bowel dysmotility. In addition, this case augments the growing body of literature that suggests that venlafaxine may be fatal in overdose situations.
authors.affiliation: Department of Pharmacy Services College of Pharmacy, Medical University of South Carolina, Charleston, South Carolina 29425, USA. mazurj@musc.edu
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Mazur
authors.forename: John D
authors.initials: JD
authors.lastname: Doty
authors.forename: Ashley S
authors.initials: AS
authors.lastname: Krygiel
mesh_terms: D000328:Adult; D003511:Cyclohexanols / Q000493:pharmacokinetics / Q000506:poisoning*; D062787:Drug Overdose; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017367:Selective Serotonin Reuptake Inhibitors / Q000493:pharmacokinetics / Q000506:poisoning*; D000069470:Venlafaxine Hydrochloride
chemical_list: D003511:Cyclohexanols; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride