The p210BCR-ABL tyrosine kinase of chronic myeloid leukemia causes resistance to radio-induced apoptotic death by inhibiting the proapoptotic BAX gene.
Mancini
M
M
Brusa
G
G
Benvenuti
M
M
Mazzacurati
L
L
Campanini
F
F
Barbieri
E
E
Cammelli
S
S
Calonghi
N
N
Martinelli
G
G
Baccarani
M
M
Santucci
M A
MA
D017209:Apoptosis / Q000528:radiation effects*; D016044:Fusion Proteins, bcr-abl / Q000502:physiology*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000201:enzymology / Q000473:pathology*; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger / Q000032:analysis; D011839:Radiation, Ionizing; D051028:bcl-2-Associated X Protein
C494826:BAX protein, human; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger; D051028:bcl-2-Associated X Protein; D016044:Fusion Proteins, bcr-abl