Validation of a mathematical model predicting the response to growth hormone treatment in prepubertal children with idiopathic growth hormone deficiency.
OBJECTIVE
To validate a mathematical model developed by Ranke et al. (J Clin Endocrinol Metab 1999;84:1174-7783) to predict the GH response during the first years of GH replacement therapy.


METHODS
38 children with idiopathic GH deficiency (GHD) met all inclusion criteria for the prediction model, but the group differed in some characteristics from the cohort from which the model was derived.


RESULTS
Using the model for the 1st year including maximum GH after stimulation and the equation for the 6th year, the predicted value corresponded well with actual height gain. Differences were found when the growth response of the 1st year excluding maximum GH and that of the 2nd-5th year were calculated, resulting in a significant underestimation of actual height gain (-0.63 to -1.07 cm/year).


CONCLUSIONS
The mathematical prediction model tended to underpredict the growth response to GH treatment in our patients with pronounced GHD. The severity of GHD seems to be an important parameter for the 1st year prediction.
Vosahlo
J
J
Pediatric Department, 3rd Faculty of Medicine, Prague, Czech Republic.
Zidek
T
T
Lebl
J
J
Riedl
S
S
Frisch
H
H
D001827:Body Height / Q000187:drug effects; D002648:Child; D005260:Female; D019382:Human Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008954:Models, Biological; D015203:Reproducibility of Results; D013997:Time Factors
D019382:Human Growth Hormone