title: Nonfunctioning adrenocortical carcinoma in a child.
abstract: Pediatric nonfunctioning adrenocortical carcinoma is a very rare tumor. A 4-year-old girl was admitted complaining of abdominal pain. Physical examination revealed an abdominal mass. There were no clinical or laboratory signs of hormonal abnormality. Abdominal ultrasonography revealed a polylobular mass. Intravenous pyelography showed marked compression of the kidney by a tumor. The tumor was excised together with the right kidney. The histopathological diagnosis was adrenocortical carcinoma. Although there is a greater incidence of germ line p53 mutations with adrenocortical carcinoma, the tumor suppressor gene p53 was not mutated in our case. The girl died 2 months after surgery from complications of chemotherapy.
authors.affiliation: Department of Pediatric Surgery, Harran University, Faculty of Medicine, Sanliurfa, Turkey. kanmaz@surgery.wisc.edu
authors.forename: Turan
authors.initials: T
authors.lastname: Kanmaz
authors.forename: Savas
authors.initials: S
authors.lastname: Demirbilek
authors.forename: Ilyas
authors.initials: I
authors.lastname: Ozardali
authors.forename: Mukerrem
authors.initials: M
authors.lastname: Safali
authors.forename: Sefik
authors.initials: S
authors.lastname: Guran
authors.forename: Selcuk
authors.initials: S
authors.lastname: Yucesan
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000473:pathology*; D018268:Adrenocortical Carcinoma / Q000175:diagnosis / Q000473:pathology*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D016159:Tumor Suppressor Protein p53