Acute post-bacterial glomerulonephritis in renal transplant patients: description of three cases and review of the literature.
Only a few cases of acute post-infectious glomerulonephritis have been described in renal transplant patients. We report here three cases of acute post-bacterial glomerulonephritis in renal transplants. In contrast to the classic cases of post-streptococcal glomerulonephritis the type of infection was heterogeneous: respectively, Escherichia coli bacteremia, a skin abscess, and cholangitis. The clinical presentation was characterized by a deterioration of graft function in two of our three patients. Acute renal dysfunction recovered in both patients, but in the long term the outcome was severe; two of the three patients lost their graft function. It is difficult to ascertain whether progression was due to chronic allograft nephropathy, to glomerulonephritis, or both. It may be concluded that acute post-infectious glomerulonephritis is a possible, although rare, complication in renal transplant recipients. It has an unusual presentation and may have a poor outcome in the long term. The role of therapy, if any, is still undefined.
Moroni
Gabriella
G
Division of Nephrology and Dialysis Ospedale Maggiore Policlinico IRCCS, Milan, Italy. croff1@policlinico.mi.it
Papaccioli
Daniela
D
Banfi
Giovanni
G
Tarantino
Antonio
A
Ponticelli
Claudio
C
D000208:Acute Disease; D000328:Adult; D016470:Bacteremia; D001706:Biopsy; D004926:Escherichia coli / Q000378:metabolism; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000628:therapy; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods*; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency; D013997:Time Factors; D016896:Treatment Outcome