A genome-wide screen for genes influencing conduct disorder.
While behavioral genetic studies have suggested that childhood conduct disorder is under genetic influence, studies aimed at gene identification are lacking. This study represents the first genome-wide linkage analysis directed toward identifying genes contributing to conduct disorder. Genome screens of retrospectively reported childhood conduct disorder and conduct disorder symptomatology were carried out in the genetically informative adult sample collected as part of the Collaborative Study on the Genetics of Alcoholism (COGA). The results suggest that regions on chromosomes 19 and 2 may contain genes conferring risk to conduct disorder. Interestingly, the same region on chromosome 2 has also been linked to alcohol dependence in this sample. Childhood conduct disorder is known to be associated with the susceptibility for future alcohol problems. Taken together, these findings suggest that some of the genes contributing to alcohol dependence in adulthood may also contribute to conduct disorder in childhood.
Dick
D M
DM
Indiana University, 975 West Walnut St., IB-130, Indianapolis, IN 46202-5251, USA.
Li
T-K
TK
Edenberg
H J
HJ
Hesselbrock
V
V
Kramer
J
J
Kuperman
S
S
Porjesz
B
B
Bucholz
K
K
Goate
A
A
Nurnberger
J
J
Foroud
T
T
D000328:Adult; D000437:Alcoholism / Q000235:genetics; D002648:Child; D002878:Chromosomes, Human, Pair 1; D002888:Chromosomes, Human, Pair 19; D019955:Conduct Disorder / Q000235:genetics*; D005820:Genetic Testing; D015894:Genome, Human; D006801:Humans; D008126:Lod Score; D012189:Retrospective Studies