title: Evidence for genetic factors underlying the insulin resistance syndrome in american indians.
abstract: Previous analyses of American Indians of the Strong Heart Study have demonstrated that various insulin-resistance variables cluster, although knowledge about the genetic determination of these clusters is unknown. In an effort to explore the influences on the aggregation of insulin-resistance phenotypes, we used principal component factor analysis to examine the clustering of these phenotypes in participants of the Strong Heart Family Study and evaluated the genetic and environmental contributions of such factors. Nine traits were chosen for principal component factor analysis: BMI, diastolic blood pressure, fasting glucose, high-density lipoprotein-cholesterol, natural log-transformed insulin, natural log-transformed triglycerides, percentage of body fat, systolic blood pressure, and waist-to-hip ratio. Analyses revealed three clusters: glucose/insulin/obesity, blood pressure, and dyslipidemia factors. Using a variance component approach and accounting for the effects of age, sex, center, and medication, we detected significant heritabilities (h2) for the three factors: h2 = 0.67, h2 = 0.33, and h2 = 0.61, respectively. In multivariate analysis, no significant genetic correlations among factors were found. These results suggest that heredity explains a substantial proportion of the variability of the factors that underlie the insulin resistance syndrome in American Indians and that these factors are genetically independent.
authors.affiliation: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. kari_north@unc.edu
authors.forename: Kari E
authors.initials: KE
authors.lastname: North
authors.forename: Ken
authors.initials: K
authors.lastname: Williams
authors.forename: Jeff T
authors.initials: JT
authors.lastname: Williams
authors.forename: Lyle G
authors.initials: LG
authors.lastname: Best
authors.forename: Elisa T
authors.initials: ET
authors.lastname: Lee
authors.forename: Richard R
authors.initials: RR
authors.lastname: Fabsitz
authors.forename: Barbara V
authors.initials: BV
authors.lastname: Howard
authors.forename: R Stuart
authors.initials: RS
authors.lastname: Gray
authors.forename: Jean W
authors.initials: JW
authors.lastname: MacCluer
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000235:genetics; D001794:Blood Pressure / Q000235:genetics; D001823:Body Composition / Q000235:genetics; D001824:Body Constitution / Q000235:genetics; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006949:Hyperlipidemias / Q000235:genetics; D007198:Indians, North American / Q000235:genetics*; D007328:Insulin / Q000235:genetics; D008137:Longitudinal Studies; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D009765:Obesity / Q000235:genetics*; D025341:Principal Component Analysis
chemical_list: D001786:Blood Glucose; D007328:Insulin