title: Evaluating changes in health status: sensitivity to change of the modified Arabic Health Assessment Questionnaire in patients with rheumatoid arthritis.
abstract: OBJECTIVE
  To test the correlation between clinical improvements in patients with rheumatoid arthritis (RA) as defined by the American College of Rheumatology (ACR) response criteria and functional improvements as assessed by functional measures in the modified Arabic version of the Health Assessment Questionnaire (Arabic-HAQ) and to estimate the sensitivity to change of the Arabic-HAQ, in a prospective study.
  
  
  METHODS
  Eighty-two patients with active RA were given methotrexate and followed up prospectively for 12 months. ACR response rates and score improvements on the modified Arabic-HAQ were compared.
  
  
  RESULTS
  The Arabic-HAQ scores showed significant sensitivity to change after 6 and 12 months and were significantly correlated with the ACR response. Percentages of agreement with ACR response levels were high after 6 months and higher still after 12 months. Standardized effect sizes were 2.34 and 2.84 after 6 and 12 months, respectively. Relative efficiency of the total Arabic-HAQ score in relation to the tender joint count was greater than 1.
  
  
  CONCLUSIONS
  The Arabic-HAQ is valid and sensitive to functional status changes in patients with RA. The results are comparable to those of the original HAQ. Thus, the Arabic-HAQ can be used to evaluate treatments and to identify changes that are important to RA patients.
authors.affiliation: Rheumatology and Rehabilitation Department, Ain Shams, University, Cairo, Egypt. miedanycrd@yahoo.com
authors.forename: Yasser
authors.initials: Y
authors.lastname: el-Miedany
authors.forename: Sally
authors.initials: S
authors.lastname: Youssef
authors.forename: Maha
authors.initials: M
authors.lastname: el-Gaafary
authors.forename: Ihab
authors.initials: I
authors.lastname: Ahmed
mesh_terms: D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003431:Cross-Cultural Comparison; D004534:Egypt; D005260:Female; D006304:Health Status; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use*; D008875:Middle Aged; D011446:Prospective Studies; D020127:Recovery of Function; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D014481:United States
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate