title: [Clinical and cytogenetic evaluation of patients with disorders of somato-sexual development].
abstract: Congenital somato-sexual disturbances include wide range of classic syndromes, as well as different types of numerous or isolated developmental defects. 28 women with disorders of sexual development were clinically and cytogenetically analyzed.
  
  
  OBJECTIVE
  Clinical and cytogenetic evaluation of patients with disorders of somato-sexual development.
  
  
  METHODS
  28 women, 17-35 years old, were included in the study. Analysis data were performed on the basis of clinical records from Department of Obstetrics and Woman's Diseases of Medical University in Bydgoszczy. Cytogenetic investigations were carried out on standard lymphocyte culture method.
  
  
  RESULTS
  Turner's syndrome was found in 12 women; 45, X in 7 mosaic karyotype 45, X/46, XX in 4, isochromosome i(Xq) in 1.3 women had normal, male karyotype, 46, XY. One of them had dysgenetic gonads of malignant dysplesia transformation. One patient's karyotype was 47, XXX. 12 women with gonadal dysgenesis--karyotype 46, XX.
  
  
  CONCLUSIONS
  1. Patients with congenital disorders of somato-sexual development are a heterogenous group. 2. Laparoscopy an effective diagnostic and treatment method in women with disorders of congenital somato-sexual development.
authors.affiliation: Katedry i Kliniki Połoznictwa i Chorób Kobiecych AM w Bydgoszczy.
authors.forename: Rafał
authors.initials: R
authors.lastname: Adamczak
authors.forename: Wiesław
authors.initials: W
authors.lastname: Szymański
authors.forename: Magdalena
authors.initials: M
authors.lastname: Pasińska
authors.forename: Olga
authors.initials: O
authors.lastname: Haus
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D014644:Genetic Variation; D006060:Gonadal Dysgenesis, Mixed / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D011044:Poland; D012729:Sex Chromosome Aberrations; D025064:Sex Chromosome Disorders / Q000175:diagnosis / Q000235:genetics*