Triton X-100 enhances ion-pair-driven molecular recognition in aqueous media. Further work on a chemosensor for inositol trisphosphate.
Molecular recognition in water based on ion-pairing is hampered by competition from the solvent. We have reported that synthetic receptor 1 recognizes inositol trisphosphate (IP3) with a binding constant of 10(8) M(-1) in methanol. In this paper, instead of working in methanol, we report that the surfactant Triton-X 100 also yields a large absorbance or fluorescence change and a binding constant on the order of 10(6) M(-1).
Niikura
Kenichi
K
Department of Chemistry and Biochemistry, The University of Texas, Austin, Texas 78712, USA.
Anslyn
Eric V
EV
D015374:Biosensing Techniques / Q000379:methods; D007295:Inositol Phosphates / Q000737:chemistry*; D007700:Kinetics; D017830:Octoxynol / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D014867:Water / Q000737:chemistry
D007295:Inositol Phosphates; D012997:Solvents; D014867:Water; D017830:Octoxynol