Comparison of the seroprevalence of human metapneumovirus and human respiratory syncytial virus.
Human metapneumovirus (hMPV) is a virus that induces human respiratory syncytial virus (hRSV)-like illnesses, ranging from upper respiratory tract infection to severe bronchiolitis and pneumonia. The 100 serum samples from children aged 1 month to 5 years were tested for the presence of hMPV and hRSV antibodies using an indirect immunofluorescence assay and a neutralizing-antibody assay, respectively. The seroprevalence of hMPV was significantly lower than that of hRSV in children over 4-months-old (43% vs. 60%, P < 0.025), and the difference was particularly notable between the ages of 4 months and 1 year (11% vs. 48%, P = 0.006). The results suggest that primary infection with hMPV occurs somewhat later than that with hRSV.
Ebihara
Takashi
T
Department of Pediatrics, Hokkaido University School of Medicine, Sapporo, Japan.
Endo
Rika
R
Kikuta
Hideaki
H
Ishiguro
Nobuhisa
N
Ishiko
Hiroaki
H
Kobayashi
Kunihiko
K
D000914:Antibodies, Viral / Q000097:blood*; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D029121:Metapneumovirus / Q000276:immunology*; D018184:Paramyxoviridae Infections / Q000453:epidemiology* / Q000821:virology; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology* / Q000821:virology; D018113:Respiratory Syncytial Virus, Human / Q000276:immunology*; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000821:virology; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral