Presence of spinal B7.2 (CD86) but not B7.1 (CD80) co-stimulatory molecules following peripheral nerve injury: role of nondestructive immunity in neuropathic pain.
Previous work in our laboratory demonstrated spinal neuroimmune activation and leukocyte trafficking into the central nervous system (CNS) parenchyma in a rat model of neuropathic pain. Recent studies suggest that co-stimulatory molecules B7.1 (CD80) and B7.2 (CD86) play a differential role in the effect of beneficial versus deleterious CNS autoimmune responses. In the present study, we determined the lumbar spinal expression of the co-stimulatory molecules B7.1 and B7.2 in a rat model of neuropathy. We observed intense B7.2 microglial immunoreactivity in the lumbar spinal cord following the injury but no expression of B7.1. These data suggest a role of protective CNS autoimmunity following peripheral nerve injury.
Rutkowski
M D
MD
Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
Lambert
F
F
Raghavendra
V
V
DeLeo
J A
JA
D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis / Q000502:physiology*; D018122:B7-1 Antigen / Q000096:biosynthesis / Q000502:physiology*; D051940:B7-2 Antigen; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000502:physiology*; D010147:Pain Measurement / Q000379:methods; D010523:Peripheral Nervous System Diseases / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D013116:Spinal Cord / Q000276:immunology / Q000378:metabolism; D013127:Spinal Nerves / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*
D015703:Antigens, CD; D018122:B7-1 Antigen; D051940:B7-2 Antigen; C497966:Cd86 protein, rat; D008562:Membrane Glycoproteins