[Effects of jing'an capsule on rat sperm quality].
OBJECTIVE
The effects of Jing'an capsule on the quality of rat sperm were studied to supply data for its safe clinical use.


METHODS
Eighty SD male rats were evenly and randomly divided into three test groups and one control group. Then the test groups were continuously given Jing'an capsule at different dosages: 557.1 mg/kg, 5,571 mg/kg or 11,420 mg/kg and the control group was given starch (20 g/L). Sixty days later, one of the epididymides, the sperm density was made and the sperm motility and morphology were investigated. The data obtained were analyzed by ANOVA, chi 2 test and Kruskal-Wallis test.


RESULTS
The sperm density, motility and morphology were variable at different dosages. Compared with the control, the sperm density increased significantly at the dosage of 557.1 mg/kg(P < 0.05), and a significant decrease was observed in the sperm density and motility (P < 0.05) at the dosage of 11,420 mg/kg. Although the rate of abnormal sperm morphology decreased at the dosage of 557.1 mg/kg and increased at the dosage of 5,571 mg/kg or 11,420 mg/kg compared with the control, there was no statistic significance(P < 0.05).


CONCLUSIONS
A low dosage of Jing'an capsule might ameliorate the quality of sperm, while a high dosage could do damage to sperm.
Wei
Qing
Q
Department of Toxicology, School of Public Health, Sun Yet-San University, Guangzhou, Guangdong 510080, China.
Fan
Rui-Quan
RQ
Yang
Xing-Fen
XF
Chen
Tie-Jiang
TJ
Zhu
Wei
W
Zhao
Xiao-Lin
XL
D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*; D019287:Zinc Sulfate / Q000494:pharmacology*
D004338:Drug Combinations; D019287:Zinc Sulfate; D001120:Arginine