title: Clinical and neuropsychological characteristics of pediatric epilepsy patients with atypical language dominance.
abstract: Studies on intracarotid amobarbital procedures (IAP) in pediatric patients are rare and mainly focus on practicability aspects. Very few studies have reported characteristics of children with atypical language dominance. We compared children with left-sided focal epilepsy and atypical (i.e., right or bilateral) versus left-sided language representation (n=12 versus 17). Our results indicate a higher incidence of left handedness, extratemporal lesions, an earlier onset of epilepsy, and a neuropsychological "crowding effect" with distinct nonverbal memory deficits in the atypical group. We conclude that atypical language representation in children with left-sided epilepsy is associated with similar characteristics as in adults. It is recommended that the possibility of a language shift in the presurgical workup of pediatric patients be considered, particularly if a left-hemispheric epileptic focus is suspected.
authors.affiliation: Department of Epileptology, University of Bonn, Sigmund-Freud Str. 25, 53105, Bonn, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Gleissner
authors.forename: M
authors.initials: M
authors.lastname: Kurthen
authors.forename: R
authors.initials: R
authors.lastname: Sassen
authors.forename: S
authors.initials: S
authors.lastname: Kuczaty
authors.forename: C E
authors.initials: CE
authors.lastname: Elger
authors.forename: D B
authors.initials: DB
authors.lastname: Linke
authors.forename: H
authors.initials: H
authors.lastname: Urbach
authors.forename: C
authors.initials: C
authors.lastname: Helmstaedter
mesh_terms: D000293:Adolescent; D000654:Amobarbital / Q000494:pharmacology; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000187:drug effects / Q000503:physiopathology; D002648:Child; D004292:Dominance, Cerebral; D004569:Electroencephalography; D004585:Electrooculography; D004828:Epilepsies, Partial / Q000150:complications*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007802:Language; D007806:Language Disorders / Q000209:etiology*; D008297:Male; D008568:Memory / Q000187:drug effects; D009483:Neuropsychological Tests; D014705:Verbal Behavior / Q000187:drug effects; D014888:Wechsler Scales
chemical_list: D006993:Hypnotics and Sedatives; D000654:Amobarbital