title: Phenolic thiazoles as novel orally-active neuroprotective agents.
abstract: Novel phenolic thiazoles compounds were prepared which demonstrated potent antioxidant activity and potent in vivo neuroprotection in mitochondrial toxin models and also possess good oral bioavailability.
authors.affiliation: Department of Medicinal Chemistry, Ipsen Research Laboratories, Institute Henri Beaufour, 5 Avenue du Canada, 91966 Les Ulis Cedex, France. jeremiah.harnett@ipsen.com
authors.forename: Jeremiah J
authors.initials: JJ
authors.lastname: Harnett
authors.forename: Veronique
authors.initials: V
authors.lastname: Roubert
authors.forename: Christine
authors.initials: C
authors.lastname: Dolo
authors.forename: Christelle
authors.initials: C
authors.lastname: Charnet
authors.forename: Brigitte
authors.initials: B
authors.lastname: Spinnewyn
authors.forename: Sylvie
authors.initials: S
authors.lastname: Cornet
authors.forename: Alain
authors.initials: A
authors.lastname: Rolland
authors.forename: Jean-Gregoire
authors.initials: JG
authors.lastname: Marin
authors.forename: Dennis
authors.initials: D
authors.lastname: Bigg
authors.forename: Pierre-E
authors.initials: PE
authors.lastname: Chabrier
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D020267:MPTP Poisoning / Q000378:metabolism / Q000517:prevention & control; D051379:Mice; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000737:chemistry; D010636:Phenols / Q000008:administration & dosage* / Q000737:chemistry; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism; D013844:Thiazoles / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000975:Antioxidants; D018696:Neuroprotective Agents; D010636:Phenols; D013844:Thiazoles