title: The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data.
abstract: The Catalytic Site Atlas (CSA) provides catalytic residue annotation for enzymes in the Protein Data Bank. It is available online at http://www.ebi.ac.uk/thornton-srv/databases/CSA. The database consists of two types of annotated site: an original hand-annotated set containing information extracted from the primary literature, using defined criteria to assign catalytic residues, and an additional homologous set, containing annotations inferred by PSI-BLAST and sequence alignment to one of the original set. The CSA can be queried via Swiss-Prot identifier and EC number, as well as by PDB code. CSA Version 1.0 contains 177 original hand- annotated entries and 2608 homologous entries, and covers approximately 30% of all EC numbers found in PDB. The CSA will be updated on a monthly basis to include homologous sites found in new PDBs, and new hand-annotated enzymes as and when their annotation is completed.
authors.affiliation: EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: Craig T
authors.initials: CT
authors.lastname: Porter
authors.forename: Gail J
authors.initials: GJ
authors.lastname: Bartlett
authors.forename: Janet M
authors.initials: JM
authors.lastname: Thornton
mesh_terms: D000818:Animals; D001665:Binding Sites; D002384:Catalysis; D019295:Computational Biology; D030562:Databases, Protein; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D020407:Internet
chemical_list: D004798:Enzymes