title: Chemokines in eosinophil-associated gastrointestinal disorders.
abstract: Eosinophil-associated gastrointestinal disorders (EGDs) are characterized by a pronounced cellular inflammation. Recent clinical and experimental investigations have implicated a family of molecules known as chemokines in the regulation of leukocyte recruitment in these diseases. The underlying cellular and molecular mechanisms involved in chemokine-mediated cellular infiltration are largely unknown. In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases.
authors.affiliation: Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, Australia 0200. Simon.Hogan@anu.edu.au
authors.forename: Simon P
authors.initials: SP
authors.lastname: Hogan
authors.forename: Marc E
authors.initials: ME
authors.lastname: Rothenberg
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Forbes
authors.forename: Vanessa E
authors.initials: VE
authors.lastname: Smart
authors.forename: Klaus I
authors.initials: KI
authors.lastname: Matthaei
authors.forename: Paul S
authors.initials: PS
authors.lastname: Foster
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology; D018925:Chemokines / Q000276:immunology* / Q000378:metabolism; D002631:Chemotactic Factors, Eosinophil / Q000276:immunology* / Q000502:physiology; D004802:Eosinophilia / Q000503:physiopathology*; D005767:Gastrointestinal Diseases / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology / Q000502:physiology; D018836:Inflammation Mediators / Q000378:metabolism; D018570:Risk Assessment; D012680:Sensitivity and Specificity
chemical_list: D018925:Chemokines; D002631:Chemotactic Factors, Eosinophil; D018836:Inflammation Mediators