Analysis of glycoconjugates in patients with oral squamous cell carcinoma.
BACKGROUND
Our aim was to examine the levels of glycoconjugates in plasma, erythrocyte membranes and buccal mucosa of healthy subjects and oral cancer patients.


METHODS
This study was conducted on 48 adult male oral cancer patients with various clinical stages (stage II to stage IV; 16 of each) and 16 disease-free healthy subjects who underwent surgical removal of impacted teeth or vestibuloplasty without inflammation.


RESULTS
The plasma and tumor tissues glycoconjugates levels were significantly increased, whereas the erythrocyte membranes glycoconjugates were significantly decreased in oral cancer patients as compared to healthy subjects. The levels of glycoconjugates were gradually increased from stage II to stage IV in plasma and tumor tissues and decreased in erythrocyte membranes from stage II to stage IV of oral cancer patients.


CONCLUSIONS
The increased plasma glycoconjugates can be due to the expense of erythrocyte membrane glycoconjugates or tumor tissue itself.
Manoharan
S
S
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar-608 002, Tamil Nadu, India. manshisak@yahoo.com
Padmanabhan
M
M
Kolanjiappan
K
K
Ramachandran
C R
CR
Suresh
K
K
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000378:metabolism* / Q000473:pathology; D004910:Erythrocyte Membrane / Q000378:metabolism; D006001:Glycoconjugates / Q000097:blood* / Q000378:metabolism*; D006595:Hexosamines / Q000097:blood / Q000378:metabolism; D006601:Hexoses / Q000097:blood / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000378:metabolism; D009062:Mouth Neoplasms / Q000097:blood* / Q000378:metabolism* / Q000473:pathology; D019158:N-Acetylneuraminic Acid / Q000097:blood / Q000378:metabolism; D009367:Neoplasm Staging; D011485:Protein Binding
D006001:Glycoconjugates; D006595:Hexosamines; D006601:Hexoses; D019158:N-Acetylneuraminic Acid