title: Microglandular hyperplasia has a cytomorphological spectrum overlapping with atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H).
abstract: We retrospectively evaluated cytological interpretations of conventional cervical smears in 48 cases of biopsy-proven microglandular hyperplasia and compared them with 15 negative controls. A glandular pattern was noted in all 48 cases but was predominant in 73% (35/48) of the cases. Immature metaplastic pattern was present in 71% (34/48) and was predominant in 27% (13/48). These features were not observed in negative control smears. 85% of cases (41/48) were interpreted as negative for epithelial cell abnormality. Two cases with predominantly glandular pattern (6%, 2/35) were interpreted as atypical glandular cells. Five cases with predominantly immature metaplastic pattern (38%, 5/13) showed checkerboard arrangement or rows of single cells with slightly larger atypical nuclei leading to interpretation as "atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion." The metaplastic cells with normoblast-like karyorrhectic apoptotic debris confined to the nuclear area were scattered among these cells in microglandular hyperplasia with metaplastic pattern.
authors.affiliation: Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. vshidham@mcw.edu
authors.forename: Vinod B
authors.initials: VB
authors.lastname: Shidham
authors.forename: R Nagarjun
authors.initials: RN
authors.lastname: Rao
authors.forename: Jinobya
authors.initials: J
authors.lastname: Machhi
authors.forename: Ashwini
authors.initials: A
authors.lastname: Chavan
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D004714:Endometrial Hyperplasia / Q000473:pathology*; D004848:Epithelium / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014626:Vaginal Smears; D002578:Uterine Cervical Dysplasia / Q000473:pathology*