Relaxation of arterial smooth muscle: a new function of a water-soluble degradation product of coenzyme Q (ubiquinone).
Treatment of coenzyme Q with ozone yielded a degradation product having unmodified ring that retained its spectral characteristics and a truncated side-chain that made it water-soluble. This derivative, but not the intact lipid-quinone, showed relaxation of phenylephrine-contracted rat arterial rings. This effect offers an explanation for the known hypotensive action of exogenous coenzyme Q regardless of its side-chain length.
Bindu
R
R
Department of Pharmacology, St. John's Medical College, Bangalore 560 034, India.
Venkataraman
B V
BV
Rao
Aparna V S
AV
Ramasarma
T
T
D000818:Animals; D001158:Arteries; D019587:Dietary Supplements; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D010126:Ozone / Q000737:chemistry / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D012995:Solubility; D014451:Ubiquinone / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D014867:Water
D014867:Water; D014451:Ubiquinone; D010656:Phenylephrine; D010126:Ozone