Liver cirrhosis developed after ketoconazole-induced acute hepatic injury.
We describe a previously healthy woman who developed liver cirrhosis as a sequela of acute hepatic injury that was induced by ketoconazole administration to treat onychomycosis. The initial presentation of the disease was of a typical acute hepatitis, characterized by nausea, anorexia, fatigue, and jaundice that developed during the administration of ketoconazole. Many other causes of hepatitis were absent in the patient. Even though the hepatic injury was gradually resolved for several months after cessation of the drug, the liver function was not completely restored. Six months after the onset of illness, a follow-up abdominal computed tomography and peritoneoscopic liver biopsy were performed. They revealed a marked reduction in the liver volume and a definite cirrhotic change, which persisted for more than 5 years. The case suggests that the administration of ketoconazole can cause liver cirrhosis through acute hepatic injury within a short time under certain circumstances.
Kim
Tae-Hyung
TH
Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea.
Kim
Byung-Ho
BH
Kim
Youn-Wha
YW
Yang
Dal Mo
DM
Han
Yo-Seb
YS
Dong
Seok Ho
SH
Kim
Hyo Jong
HJ
Chang
Young-Woon
YW
Lee
Joung Il
JI
Chang
Rin
R
D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications*; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000009:adverse effects*; D008103:Liver Cirrhosis / Q000209:etiology*
D000935:Antifungal Agents; D007654:Ketoconazole