title: The diagnostic dilemma of follicular variant of papillary thyroid carcinoma.
abstract: BACKGROUND
  Given the difference in surgical management between follicular neoplasms and papillary thyroid carcinoma (PTC), we sought to determine the sensitivity of fine-needle aspiration (FNA) and intraoperative pathologic study (IP), frozen section and cytologic study, in establishing a diagnosis of follicular variant of papillary thyroid carcinoma (FVPTC) and how these techniques impact operative management.
  
  
  METHODS
  A retrospective chart review was performed of patients who underwent thyroidectomy for nodular disease between June 1997 and June 2002 identifying patients with a final diagnosis of FVPTC. FNA and IP results were reviewed in this group of patients and correlated with those of final histopathologic study. The sensitivity of FNA and IP was calculated.
  
  
  RESULTS
  Eighty-two patients had a final diagnosis of FVPTC. Eighty-six preoperative FNAs were obtained in 80 patients, leading to a diagnosis of PTC in 7 (sensitivity 9%). Intraoperative pathologic study was performed in 31 patients with suspicious FNA results, of which 13 were definitive for PTC (sensitivity 42%). Overall, IP was obtained in 42 patients, of which 15 were positive for PTC (sensitivity 36%).
  
  
  CONCLUSIONS
  Although the sensitivity of FNA in establishing a diagnosis of FVPTC is low, FNA identifies patients with suspicious lesions in whom IP is important in guiding operative management.
authors.affiliation: Department of Surgery, Division of Endocrinology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
authors.forename: Susan B
authors.initials: SB
authors.lastname: Kesmodel
authors.forename: Kyla P
authors.initials: KP
authors.lastname: Terhune
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Canter
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Mandel
authors.forename: Virginia A
authors.initials: VA
authors.lastname: LiVolsi
authors.forename: Zubair W
authors.initials: ZW
authors.lastname: Baloch
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Fraker
mesh_terms: D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle / Q000379:methods*; D018265:Carcinoma, Papillary, Follicular / Q000175:diagnosis / Q000473:pathology*; D003584:Cytological Techniques / Q000379:methods*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology*; D013965:Thyroidectomy / Q000379:methods