[Combined preoperative xeloda and radiotherapy for lower rectal cancer].
OBJECTIVE
To evaluate the effect of combined preoperative xeloda and pelvic radiotherapy on locally advanced lower rectal cancer.


METHODS
Sixty lower rectal cancer patients were divided randomly into two groups. 30 patients (Group A) were treated with operation alone and 30 patients (Group B) were treated with xeloda and radiotherapy before operation.


RESULTS
The operative resection, anal preservation and local recurrence rates were 86.66%, 33.33%, 15.38% in group A and 100%, 83.33%, 0% in group B (P < 0.05 and P < 0.01).


CONCLUSIONS
Combined preoperative xeloda and radiotherapy for lower rectal cancer is able to significantly improve the operative resection, anal preservation and decrease the local recurrence rates.
Zhuang
Chao-ping
CP
Department of General Surgery, Second Hospital of Shantou Medical College, Shantou University, Guangdong 515041, China.
Li
Ting-han
TH
Wu
Jun-wei
JW
Cai
Gao-yang
GY
D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D000069287:Capecitabine; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects; D012004:Rectal Neoplasms / Q000628:therapy*
D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil