Acquired rippling muscle disease with myasthenia gravis.
Rippling muscle disease (RMD) is a rare disorder that occurs in both familial and sporadic forms. Seven patients have previously been reported with myasthenia gravis and sporadic RMD. There have been conflicting reports of the electrophysiological characteristics of rippling muscles in this acquired form. Another such patient is reported, and the clinical, electrophysiological, and laboratory features of this disorder are described. In addition, this patient had alopecia areata and recurrent metastatic thymoma, years after resection of a benign thymoma. This report emphasizes the clinical manifestations of RMD in association with myasthenia gravis (RMD-MG), and its distinctive features, in this and previously reported patients.
Greenberg
Steven A
SA
Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA. sagreenberg@partners.org
D000328:Adult; D000506:Alopecia Areata / Q000150:complications; D000970:Antineoplastic Agents / Q000494:pharmacology; D004576:Electromyography; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D018485:Muscle Fibers, Skeletal / Q000378:metabolism / Q000473:pathology; D018908:Muscle Weakness / Q000209:etiology / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology*; D009135:Muscular Diseases / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D009157:Myasthenia Gravis / Q000150:complications*; D009364:Neoplasm Recurrence, Local / Q000150:complications; D011241:Prednisone / Q000494:pharmacology; D013945:Thymoma / Q000150:complications*; D013953:Thymus Neoplasms / Q000150:complications*
D000970:Antineoplastic Agents; D011241:Prednisone