[Polymorphism of serotonin receptor gene 5-HTR2A and schizotypic traits in mentally healthy subjects].
Serotonin receptor type 2 (5-HTR2A) polymorphism was consistently reported to be related to schizophrenia and some clinical presentations of the disease. The present study aimed at searching for association between 5-HTR2A polymorphism and schizotypic personality traits being considered as recognized phenotype predisposing to schizophrenia. Relationship between these features measured by SPQ-74 and two 5-HTR2A polymorphic loci has been studied in mentally healthy community sample (n = 64). Significant difference was found between AG and GG genotype carriers on No-close-friends scale (t = 2.3; p = 0.03), with GG scoring higher on this item. Also, a trend towards higher scores on this scale (p = 0.08) was observed in women, but not in men, with A2A2 genotype. To a certain extent, the results confirm a hypothesis articulated in the study of G-allele and A2-allele relation to interpersonal relationship factor of SPQ-74.
Mitiushina
N G
NG
Alfimova
M V
MV
Liashenko
G L
GL
Asanov
A Iu
AIu
Golimbet
V E
VE
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000483:Alleles; D016009:Chi-Square Distribution; D017931:DNA Primers; D003627:Data Interpretation, Statistical; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010551:Personality; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011779:Q-Sort; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D012737:Sex Factors; D011795:Surveys and Questionnaires
D017931:DNA Primers; D044402:Receptor, Serotonin, 5-HT2A