Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.
Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Abeta42 levels suggesting that a single locus may influence risk for AD by elevating plasma Abeta42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data.
Myers
Amanda J
AJ
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA. myersa@mail.nih.gov
Marshall
Helen
H
Holmans
Peter
P
Compton
Danielle
D
Crook
Richard J P
RJ
Mander
Adrian P
AP
Nowotny
Petra
P
Smemo
Scott
S
Dunstan
Melanie
M
Jehu
Luke
L
Wang
Jen C
JC
Hamshere
Marian
M
Morris
John C
JC
Norton
Joanne
J
Chakraventy
Sumi
S
Tunstall
Nigel
N
Lovestone
Simon
S
Petersen
Ronald
R
O'Donovan
Michael
M
Jones
Lesley
L
Williams
Julie
J
Owen
Michael J
MJ
Hardy
John
J
Goate
Alison
A
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D014568:Urokinase-Type Plasminogen Activator / Q000235:genetics*
D014568:Urokinase-Type Plasminogen Activator