RNA polymerase III transcription--a battleground for tumour suppressors and oncogenes.
This review provides a summary of the European Association for Cancer Research Award Lecture, presented at the ECCO12 meeting in Copenhagen in September 2003. It describes what we have learnt about the mechanisms responsible for deregulating RNA polymerase III transcription in transformed cells. A network has been discovered of unanticipated links to key tumour suppressors and oncogenes. Novel functions have been revealed for RB, p53 and c-Myc, that may help explain their profound biological effects.
White
R J
RJ
Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow G12 8QQ, UK.rwhite@udcg.gla.ac.uk
D002455:Cell Division; D048429:Cell Size; D016147:Genes, Tumor Suppressor; D006801:Humans; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics*; D009857:Oncogenes; D012320:RNA Polymerase III / Q000037:antagonists & inhibitors / Q000235:genetics*; D016160:Retinoblastoma Protein / Q000378:metabolism; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000378:metabolism; D014158:Transcription, Genetic
D016160:Retinoblastoma Protein; D014157:Transcription Factors; D012320:RNA Polymerase III