title: Sex-steroid derived compounds induce sex-specific effects on autonomic nervous system function in humans.
abstract: The physiological and psychological effects of 2 human sex-steroid derived compounds, 4.16-androstadien-3-one (AND) and l,3,5(10),16-estratetraen-3-ol(EST) were measured in 24 subjects who participated in a within-subjects, double-blind experiment. A dissociation was evident in the physiological effects of AND, in that it increased physiological arousal in women but decreased it in men. EST did not significantly affect physiological arousal in women or men. Neither compound significantly affected mood. AND is an androgen derivative that is the most prevalent androstene in human male sweat, male axillary hair, and on the male axillary skin surface. The authors argue that AND's opposite effects on physiology in men and women further implicate this compound in chemical communication between humans.
authors.affiliation: Department of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley 94720, USA. bensafi@uclink.berkeley.edu
authors.forename: M
authors.initials: M
authors.lastname: Bensafi
authors.forename: W M
authors.initials: WM
authors.lastname: Brown
authors.forename: T
authors.initials: T
authors.lastname: Tsutsui
authors.forename: J D
authors.initials: JD
authors.lastname: Mainland
authors.forename: B N
authors.initials: BN
authors.lastname: Johnson
authors.forename: E A
authors.initials: EA
authors.lastname: Bremner
authors.forename: N
authors.initials: N
authors.lastname: Young
authors.forename: I
authors.initials: I
authors.lastname: Mauss
authors.forename: B
authors.initials: B
authors.lastname: Ray
authors.forename: J
authors.initials: J
authors.lastname: Gross
authors.forename: J
authors.initials: J
authors.lastname: Richards
authors.forename: I
authors.initials: I
authors.lastname: Stappen
authors.forename: R W
authors.initials: RW
authors.lastname: Levenson
authors.forename: N
authors.initials: N
authors.lastname: Sobel
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects; D000704:Analysis of Variance; D000730:Androstadienes / Q000494:pharmacology*; D001143:Arousal / Q000187:drug effects*; D001341:Autonomic Nervous System / Q000187:drug effects*; D004311:Double-Blind Method; D004963:Estrenes / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009812:Odorants; D012724:Sex Attractants / Q000494:pharmacology*; D012737:Sex Factors
chemical_list: D000730:Androstadienes; D004963:Estrenes; D012724:Sex Attractants; C021674:1,3,5,(10),16-estratetraen-3-ol; C003524:4,16-androstadien-3-one