[Manifestations of oxidative stress and its correction in traumatic shock].
The case study purpose was to investigate the oxidation-antioxidation process in the affected organism after traumatic shock and under the impact of Plapherone LB. A randomized experiment involved 94 patients who were shared between 2 groups: group 1--routine intensive therapy, group 2--it received additionally Plapherone LB (sublingually, 2 mg protein/day). Ten persons of the control group were investigated separately. It was found by the method of electron paramagnet resonance that the antixidant system became weaker (in patients with traumatic chock), the lipoid oxidants got more intensified, the activity of their oxidant enzymes went up and the concentration of free radical got to be higher. Finally, Plapherone LB was found to promote the optimization of such systemic changes, since it normalized the xanthine oxidase activity in experimental traumatic shock.
Nakashidze
I
I
Chikovani
T
T
Sanikidze
T
T
Bakhutashvili
V
V
D000975:Antioxidants / Q000627:therapeutic use*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005609:Free Radicals / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D008706:Methemoglobin / Q000032:analysis; D009479:Neuropeptides / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects*; D011941:Receptors, Adrenergic / Q000097:blood / Q000378:metabolism; D012774:Shock, Traumatic / Q000097:blood* / Q000378:metabolism*; D015599:Trauma Severity Indices
D000975:Antioxidants; D005609:Free Radicals; D008054:Lipid Peroxides; D009479:Neuropeptides; D011941:Receptors, Adrenergic; C091912:plaferon; D008706:Methemoglobin