title: Tumefactive lipedema with pseudoxanthoma elasticum-like microscopic changes.
abstract: BACKGROUND
  Lipedema is a condition characterized by diffuse, bilaterally symmetrical, painful swelling of the legs and buttocks. Microscopically, there are dermal and septal edema, adipocyte degeneration, and numerous mast cells, features held in common with lipedematous alopecia.
  
  
  METHODS
  We present the case of a 60-year-old woman with a long history of bilateral leg masses with microscopic features of lipedema. In addition, elastic-fiber changes typical of pseudoxanthoma elasticum (PXE) were discovered within the subcutaneous septa in three separate specimens obtained from an affected extremity. The patient did not have other clinical findings of PXE, although there was a history of both hypertension and congestive heart failure.
  
  
  CONCLUSIONS
  This tumefactive presentation of lipedema has not been previously described. Regarding the elastic-tissue abnormalities, the patient could have either a subclinical form of PXE, perhaps predisposing to lipedema, or secondary elastic-tissue changes resulting from the massive edema. If the latter is the case, then this could represent an unusual manifestation of localized acquired cutaneous PXE (calcific elastosis).
authors.affiliation: Department of Pathology, University of Virginia Health System, Charlottesville, VA, USA.
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Taylor
authors.forename: William C
authors.initials: WC
authors.lastname: Foster
authors.forename: Mark R
authors.initials: MR
authors.lastname: Wick
authors.forename: James W
authors.initials: JW
authors.lastname: Patterson
mesh_terms: D000273:Adipose Tissue / Q000473:pathology* / Q000601:surgery; D004487:Edema / Q000150:complications / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D011561:Pseudoxanthoma Elasticum / Q000150:complications / Q000473:pathology* / Q000601:surgery