Giant-cell tumors of bone and progesterone receptors.
Estrogen receptors, progesterone receptors, and cathepsin D were determined in 10 patients with giant-cell bone tumor. Progesterone receptors were expressed in 5 of 10 patients tested, whereas low levels of estrogen receptors were found in 1 patient. Cathepsin D levels were elevated in 5 of 5 samples studied. High values of progesterone receptors correlated with low tumor grade. Cathepsin D levels correlated negatively with tumor grade but positively with local tumor expansion. Giant-cell bone tumor expressing progesterone receptors may manifest benign behavior. Cathepsin D may be involved in tumor expansion, possibly through its effect on bone resorption.
Demertzis
Nikolaos
N
Department of Orthopedics, Metaxa Hospital, Athens, Greece.
Kotsiandri
Fani
F
Giotis
Ioulia
I
Apostolikas
Nikiphoros
N
D000328:Adult; D001859:Bone Neoplasms / Q000378:metabolism* / Q000601:surgery; D002402:Cathepsin D / Q000378:metabolism*; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000378:metabolism* / Q000601:surgery; D011256:Pregnancy Outcome; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D002402:Cathepsin D