Antioxidant activity of topically applied lycopene.
BACKGROUND
Ultraviolet (UV) rays cause depletion of the antioxidant substances contained in the epidermis. This is the rationale for the use of topical antioxidant substances.


METHODS
We studied the protective activity against UV radiation of a product based on lycopene and a product containing a mixture of vitamins E and C. Photostimulation was applied with a solar simulator and the cutaneous response was evaluated instrumentally.


RESULTS
The lycopene-based product had a much greater protective ability than the product containing the mixture of vitamins.


CONCLUSIONS
Lycopene has suitable characteristics to be used successfully in the prevention of cutaneous damage by free radicals. Its antioxidant ability is probably due to its high reductive power.
Andreassi
M
M
Dipartimento Farmaco Chimico Tecnologico, Istituto di Scienze Dermatologiche, Università degli Studi di Siena, Siena, Italy. andreassi2@unisi.it
Stanghellini
E
E
Ettorre
A
A
Di Stefano
A
A
Andreassi
L
L
D000287:Administration, Topical; D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000494:pharmacology; D002338:Carotenoids / Q000008:administration & dosage / Q000494:pharmacology*; D004655:Emulsions; D005260:Female; D005782:Gels; D006801:Humans; D000077276:Lycopene; D008297:Male; D012867:Skin / Q000187:drug effects / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects*; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology
D000975:Antioxidants; D004655:Emulsions; D005782:Gels; D014810:Vitamin E; D002338:Carotenoids; D001205:Ascorbic Acid; D000077276:Lycopene