title: Reduced short-term obsessive-compulsive symptoms in schizophrenic patients treated with risperidone: a single-blind prospective study.
abstract: BACKGROUND
  Risperidone is a widely used agent as first-line treatment in schizophrenia with a favorable side-effect profile. However, a number of case reports have suggested an increase in obsessive-compulsive symptoms in patients treated with risperidone.
  
  
  OBJECTIVE
  The aim of this study was to investigate the effect of risperidone on obsessive-compulsive symptoms in the treatment of schizophrenia.
  
  
  METHODS
  Forty patients with DSM-IV diagnosis of schizophrenia were included in the study. The Yale-Brown obsessive compulsive scale was administered before, at the end of first and second months of treatment. Paired-samples t-test was used to compare the three assessments.
  
  
  RESULTS
  There was not an increase, but a significant decrease, in YBOCS scores over time during risperidone treatment (p<0.05).
  
  
  CONCLUSIONS
  In the present study risperidone caused a significant decrease in obsessive-compulsive symptoms in the treatment of schizophrenia.
authors.affiliation: Department of Psychiatry, School of Medicine, Ege University, Bornova, Izmir, Turkey. veznedaroglu@superonline.com
authors.forename: Baybars
authors.initials: B
authors.lastname: Veznedaroglu
authors.forename: Eyup Sabri
authors.initials: ES
authors.lastname: Ercan
authors.forename: Bulent
authors.initials: B
authors.lastname: Kayahan
authors.forename: Azmi
authors.initials: A
authors.lastname: Varan
authors.forename: Erhan
authors.initials: E
authors.lastname: Bayraktar
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000188:drug therapy*; D011446:Prospective Studies; D018967:Risperidone / Q000627:therapeutic use*; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy*
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone