Preparation and study on the solid inclusion complex of sparfloxacin with beta-cyclodextrin.
The interaction of sparfloxacin with beta-cyclodextrin (beta-CD) has been studied by several analytical techniques, including 1H-NMR, 13C-NMR, fluorescence spectroscopy, infrared spectroscopy, thermal analysis, and scanning electron microscope. In this paper, solid inclusion complex of sparfloxacin with beta-CD was synthesized by the coprecipitation method. In addition, the characterization of the inclusion complex has been proved by fluorimetry, Infrared, differential scanning calorimetry and 1D, 2D NMR. The experimental results confirmed the existence of 1:1 inclusion complex of sparfloxacin with beta-CD. The formation constant of complex was determined by fluorescence method and 1H-NMR. Spacial configuration of complex has been proposed on 2D NMR techniques.
Chao
Jian-Bin
JB
The Test and Analysis Center of Shanxi University, TaiYuan 030006, China. cszyxyxm@sxu.edu.cn
Tong
Hong-Bo
HB
Huang
Shu-Ping
SP
Liu
Dian-Sheng
DS
D002152:Calorimetry, Differential Scanning; D003505:Cyclodextrins / Q000737:chemistry*; D024841:Fluoroquinolones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D008956:Models, Chemical; D013050:Spectrometry, Fluorescence; D013055:Spectrophotometry, Infrared; D013696:Temperature; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D024841:Fluoroquinolones; D047392:beta-Cyclodextrins; C031215:betadex; C061363:sparfloxacin