Antinucleair antibody (ANA) positivity caused by paraneoplastic antibodies due to abundant p53 expression in early hepatic carcinoma.
A 51-year-old patient is described who presented with locomotor pain and highly significant positive ANA due to p53 antibodies, which appeared to be associated with primary hepatic carcinoma.
Westra
R
R
Department of Rheumatology, Medical Centre Leeuwarden, PO Box 888, 8901 BR Leeuwarden, The Netherlands.
Jansen
T L Th A
TL
Gouw
A S H
AS
de Jong
K P
KP
D000974:Antibodies, Antinuclear / Q000032:analysis*; D006528:Carcinoma, Hepatocellular / Q000276:immunology / Q000473:pathology*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D008113:Liver Neoplasms / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D000974:Antibodies, Antinuclear; D016159:Tumor Suppressor Protein p53