title: Constitutive EGFR signaling confers a motile phenotype to neural stem cells.
abstract: The epidermal growth factor receptor (EGFR) has been shown to play an important role in brain development, including stem and precursor cell survival, proliferation, differentiation, and migration. To further examine the temporal and spatial requirements of erbB signals in uncommitted neural stem cells (NSCs), we expressed the ligand-independent EGF receptor, EGFRvIII, in C17.2 NSCs. These NSCs are known to migrate and to evince a tropic response to neurodegenerative environments in vivo but for which an underlying mechanism remains unclear. We show that enhanced erbB signaling via constitutive kinase activity of EGFRvIII in NSCs sustains an immature phenotype and enhances NSC migration.
authors.affiliation: Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. boockvaj@uphs.upenn.edu
authors.forename: John A
authors.initials: JA
authors.lastname: Boockvar
authors.forename: Dmitri
authors.initials: D
authors.lastname: Kapitonov
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Kapoor
authors.forename: Joost
authors.initials: J
authors.lastname: Schouten
authors.forename: George J
authors.initials: GJ
authors.lastname: Counelis
authors.forename: Oliver
authors.initials: O
authors.lastname: Bogler
authors.forename: Evan Y
authors.initials: EY
authors.lastname: Snyder
authors.forename: Tracy K
authors.initials: TK
authors.lastname: McIntosh
authors.forename: Donald M
authors.initials: DM
authors.lastname: O'Rourke
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D066246:ErbB Receptors / Q000096:biosynthesis* / Q000235:genetics*; D018773:Genes, erbB-1 / Q000502:physiology; D008297:Male; D009474:Neurons / Q000378:metabolism*; D010641:Phenotype; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000378:metabolism*
chemical_list: C410723:epidermal growth factor receptor VIII; D066246:ErbB Receptors