Concise and efficient synthesis of 4-fluoro-1H-pyrrolo[2,3-b]pyridine.
Two routes describing the preparation of 4-fluoro-1H-pyrrolo[2,3-b]pyridine (4a) from 1H-pyrrolo[2,3-b]pyridine N-oxide (1) are presented. Regioselective fluorination was achieved using either the Balz-Schiemann reaction or lithium-halogen exchange. [reaction: see text]
Thibault
Carl
C
Department of Discovery Chemistry, Pharmaceutical Research Institute, Bristol-Myers Squibb, 100 boulevard de l'Industrie, Candiac, Québec, Canada J5R 1J1.
L'Heureux
Alexandre
A
Bhide
Rajeev S
RS
Ruel
Réjean
R