2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors.
Structure-activity studies on benzamide 1 obtained from library screening led to the discovery of a novel series of potent and selective glycine transporter type-2 inhibitors.
Ho
Koc-Kan
KK
Pharmacopeia, Inc., PO Box 5350, Princeton, NJ 08543-5350, USA. kanho@pharmacorp.com
Appell
Kenneth C
KC
Baldwin
John J
JJ
Bohnstedt
Adolph C
AC
Dong
Guizhen
G
Guo
Tao
T
Horlick
Robert
R
Islam
Khondaker R
KR
Kultgen
Steven G
SG
Masterson
Christopher M
CM
McDonald
Edward
E
McMillan
Kirk
K
Morphy
J Richard
JR
Rankovic
Zoran
Z
Sundaram
Hardy
H
Webb
Maria
M
D026921:Amino Acid Transport Systems, Neutral / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D001549:Benzamides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D016466:CHO Cells; D006224:Cricetinae; D005998:Glycine / Q000037:antagonists & inhibitors / Q000378:metabolism*; D050487:Glycine Plasma Membrane Transport Proteins; D006801:Humans
D026921:Amino Acid Transport Systems, Neutral; D001549:Benzamides; D050487:Glycine Plasma Membrane Transport Proteins; D005998:Glycine