Breath-odor evaluation by detection of volatile sulfur compounds--correlation with organoleptic odor ratings.
Volatile sulfur compounds are known to be major contributors to oral malodor, and their detection by gas chromatography (GC) is a commonly used method for evaluating breath odor in clinical trials. A custom-designed breath-sampling GC system was developed for this purpose. A clinical study was performed to compare the performance of this instrumental method to organoleptic evaluation by trained odor judges. A statistically significant correlation was found between the measured levels of volatile sulfurs and the ratings of the odor judges. Both methods performed similarly in evaluating the breath-freshening effects of two test products. These results demonstrate the strength of the GC method for evaluating breath odor and predicting the breath-freshening effects of oral-care products.
Hunter
Catherine M
CM
Colgate-Palmolive Company Technology Center, Piscataway, New Jersey, USA.
Niles
Hollandra P
HP
Lenton
Patricia A
PA
Majerus
Georgia J
GJ
Vazquez
Joe
J
Kloos
Clifford
C
Subramanyam
Ravi
R
Williams
Malcolm I
MI
Cummins
Diane
D
D000328:Adult; D001944:Breath Tests / Q000379:methods*; D002849:Chromatography, Gas; D004311:Double-Blind Method; D006209:Halitosis / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D018709:Statistics, Nonparametric; D013457:Sulfur Compounds / Q000032:analysis*
D013457:Sulfur Compounds