title: Binding of an imidazopyridoindole at imidazoline I2 receptors.
abstract: 3,5,6,11-Tetrahydro-2H-imidazo[1',2':1,2]pyrido[3,4-b]indole (10) might be viewed as a fusion structure of two classes of I(2) imidazoline receptor ligands: 2-(2-benzofuranyl)-2-imidazolines and beta-carbolines. Its high affinity (K(i)=7.3 nM) provides insight to how the two classes of agents might bind relative to one another at I(2) receptors.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23298, USA. glennon@hsc.vcu.edu
authors.forename: Richard A
authors.initials: RA
authors.lastname: Glennon
authors.forename: Brian
authors.initials: B
authors.lastname: Grella
authors.forename: Robin J
authors.initials: RJ
authors.lastname: Tyacke
authors.forename: Alice
authors.initials: A
authors.lastname: Lau
authors.forename: Julie
authors.initials: J
authors.lastname: Westaway
authors.forename: Alan L
authors.initials: AL
authors.lastname: Hudson
mesh_terms: D000818:Animals; D007093:Imidazoles / Q000737:chemistry / Q000378:metabolism*; D054755:Imidazoline Receptors; D007211:Indoles / Q000737:chemistry / Q000378:metabolism*; D008297:Male; D011485:Protein Binding / Q000502:physiology; D011728:Pyridones / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011955:Receptors, Drug / Q000378:metabolism*
chemical_list: D007093:Imidazoles; D054755:Imidazoline Receptors; D007211:Indoles; D011728:Pyridones; D011955:Receptors, Drug; C029899:imidazole