Synthesis of 4-methyl-thio-phenyl-propylamine and the evaluation of its interaction with different amine oxidases.
A new molecule, the 4-methyl-thio-phenyl-propylamine (PrNH(2)) was synthesized and its biological interaction with different amine oxidases such as semicarbazide sensitive amine oxidase (SSAO) [E.C.1.4.3.6], and monoamine oxidase [E.C.1.4.3.4] under its two isoforms, MAO A and MAO B, has been assessed. The substrate specifities of MAO and SSAO overlap to some extent. In this context, the search of new molecules, able to discriminate between these different amine oxidases is very important as it will allow greater elucidation of the SSAO's role in physiological and pathological conditions. We report for the first time, the synthesis and evaluation of a new molecule which has a high affinity towards the SSAO family of enzymes, more so than previously described and furthermore an ability to discriminate between the different amine oxidases.
Gallardo-Godoy
Alejandra
A
Institut de Neurociències-Departament de Bioqui;mica i Biologia Molecular, Facultat de Medicina, Universitat Autónoma de Barcelona, Campus Universitari de Bellaterra, E-08193 Bellaterra, Barcelona, Spain.
Hernandez
Mar
M
Sanz
Elisenda
E
Unzeta
Mercedes
M
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors; D000818:Animals; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D011437:Propylamines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013379:Substrate Specificity / Q000187:drug effects
D008996:Monoamine Oxidase Inhibitors; D011437:Propylamines; D006631:Amine Oxidase (Copper-Containing); D008995:Monoamine Oxidase