Roles of the intercellular adhesion molecule nectin in intracellular signaling.
The nectin family comprises four Ca(2+)-independent immunoglobulin-like cell-cell adhesion molecules. Each nectin homophilically and heterophilically trans-interacts and causes intercellular adhesion, which organizes a variety of intercellular junctions in cooperation with, or independently of, cadherin. Nectin furthermore induces activation of Cdc42 and Rac small G proteins through c-Src, which eventually regulates formation of the cadherin-based adherens junctions through reorganization of the actin cytoskeleton, gene expression through activation of a mitogen-activated protein kinase cascade, and cell polarization through cell polarity proteins. We describe here the roles of nectin in intracellular signaling.
Shimizu
Kazuya
K
Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita 565-0871.
Takai
Yoshimi
Y
D000818:Animals; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology*; D005786:Gene Expression Regulation; D000075983:Nectins; D015398:Signal Transduction; D020764:cdc42 GTP-Binding Protein / Q000378:metabolism; D020744:rac GTP-Binding Proteins / Q000378:metabolism
D015815:Cell Adhesion Molecules; D000075983:Nectins; D020764:cdc42 GTP-Binding Protein; D020744:rac GTP-Binding Proteins