Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats.
Kenny
P J
PJ
The Scripps Research Institute, Department of Neuropharmacology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. pjkenny@scripps.edu
Paterson
N E
NE
Boutrel
B
B
Semenova
S
S
Harrison
A A
AA
Gasparini
F
F
Koob
G F
GF
Skoubis
P D
PD
Markou
A
A
D000818:Animals; D001921:Brain / Q000502:physiology*; D003042:Cocaine / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000523:psychology*; D004305:Dose-Response Relationship, Drug; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D012201:Reward; D014029:Tobacco Use Disorder / Q000523:psychology*
D018722:Nicotinic Agonists; D011725:Pyridines; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; D009538:Nicotine; C121465:6-methyl-2-(phenylethynyl)pyridine; D003042:Cocaine