Single nucleotide polymorphism study of IDDM 17 in a Bedouin Arab family.
Type 1 diabetes is an autoimmune disease caused by a combination of genetic and environmental factors. On the basis of a genomic search for linkage in a Bedouin Arab family with 19 members with type 1 diabetes, we previously mapped the IDDM 17 locus to the chromosome 10q25.1 region. The result from a recent genome scan showed suggestive evidence of linkage of IDDM 17 in a subset of Caucasian families in which all affected individuals have DR3, indicating that the IDDM 17 locus might have a measurable effect in Caucasian populations from the United Kingdom and the United States. High-resolution SNP typing provides strong evidence of linkage disequilibrium to the IDDM 17 locus.
Bao
Fei
F
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
Babu
Sunanda R
SR
Roberts
Christine M
CM
Martin
Allison K
AK
Gowan
Katherine
K
Eisenbarth
George S
GS
Fain
Pamela R
PR
D018912:Arabs; D002879:Chromosomes, Human, Pair 10; D003922:Diabetes Mellitus, Type 1 / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide