title: Primary Rosai-Dorfman disease of bone without lymphadenopathy diagnosed by fine needle aspiration cytology. A case report.
abstract: BACKGROUND
  Solitary bone involvement without lymphadenopathy is a rare manifestation of Rosai-Dorfman disease, or sinus histiocytosis with massive lymphadenopathy (SHML). Only 11 cases have been reported in the literature to date, all diagnosed on histology.
  
  
  METHODS
  A 7-year-old girl had a radiolucent, lytic lesion in the shaft of the tibia clinically simulating Ewing's sarcoma. Fine needle aspiration cytology (FNAC) showed a microscopic picture typical--of SHML. There was no lymphadenopathy.
  
  
  CONCLUSIONS
  Rosai-Dorfman disease sometimes involves bone without lymphadenopathy and can be diagnosed confidently on FNAC. To the best of our knowledge, this is the 12th case report of solitary bone involvement.
authors.affiliation: Department of Pathology, King George's Medical College, Lucknow, U.P., India.
authors.forename: Madhu Mati
authors.initials: MM
authors.lastname: Goel
authors.forename: Padam Kumari
authors.initials: PK
authors.lastname: Agarwal
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Agarwal
mesh_terms: D044963:Biopsy, Fine-Needle; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D002648:Child; D003937:Diagnosis, Differential; D018483:Diaphyses / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006644:Histiocytes / Q000473:pathology*; D015618:Histiocytosis, Sinus / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008206:Lymphatic Diseases / Q000473:pathology; D011859:Radiography; D009418:S100 Proteins / Q000378:metabolism; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D009418:S100 Proteins