title: Detection of reversed basilar flow with power-motion Doppler after acute occlusion predicts favorable outcome.
abstract: OBJECTIVE
  Power-motion transcranial Doppler PMD-TCD is a new method for simultaneous display of flow at multiple depths. We aimed to determine clinical significance of PMD-TCD demonstration of reversed basilar flow in patients with basilar artery (BA) occlusion.
  
  
  METHODS
  We prospectively evaluated patients with acute vertebrobasilar ischemia using PMD-TCD. Using a predefined set of TCD depth criteria and specific flow findings, occlusion was localized to the proximal, middle, or distal BA stem. The National Institutes of Health Stroke Scale was used to measure stroke severity and the modified Rankin Scale (mRS) to assess outcome at 3 months.
  
  
  RESULTS
  BA occlusion was diagnosed in 16 patients (3 women, mean age 65, median NIHSS 8, mean time from symptoms onset 8.5 hours). PMD-TCD diagnosis of BA occlusion was confirmed in 11 of 12 patients who underwent invasive angiography. Reversed BA flow on PMD-TCD was identified in 8 patients (50%). Angiography confirmed flow from carotid system in 6 of these 8 patients (kappa=0.87). Patients with reversed BA flow showed lower NIHSS scores on admission (median 4 versus 15.5, P=0.009), on discharge (2 versus 21.5, P=0.03) and did not experience neurological deterioration during hospital stay (n=0 versus 4, P=0.05). There was a trend toward better outcome at 3 months (mRS 1 versus 4, P=0.07).
  
  
  CONCLUSIONS
  Detection of reversed flow in the distal BA with PMD-TCD is associated with lower stroke severity and better outcome after acute basilar artery occlusion.
authors.affiliation: Stroke Treatment Team, Medical School, The University of Texas-Houston, USA. marcriboj@hotmail.com
authors.forename: Marc
authors.initials: M
authors.lastname: Ribo
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Garami
authors.forename: Ken
authors.initials: K
authors.lastname: Uchino
authors.forename: Joon
authors.initials: J
authors.lastname: Song
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Molina
authors.forename: Andrei V
authors.initials: AV
authors.lastname: Alexandrov
mesh_terms: D000208:Acute Disease; D000368:Aged; D001488:Basilar Artery / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001783:Blood Flow Velocity; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D017585:Ultrasonography, Doppler, Transcranial / Q000295:instrumentation / Q000379:methods*; D014715:Vertebrobasilar Insufficiency / Q000000981:diagnostic imaging* / Q000503:physiopathology*