title: Here is the evidence, now what is the hypothesis? The complementary roles of inductive and hypothesis-driven science in the post-genomic era.
abstract: It is considered in some quarters that hypothesis-driven methods are the only valuable, reliable or significant means of scientific advance. Data-driven or 'inductive' advances in scientific knowledge are then seen as marginal, irrelevant, insecure or wrong-headed, while the development of technology--which is not of itself 'hypothesis-led' (beyond the recognition that such tools might be of value)--must be seen as equally irrelevant to the hypothetico-deductive scientific agenda. We argue here that data- and technology-driven programmes are not alternatives to hypothesis-led studies in scientific knowledge discovery but are complementary and iterative partners with them. Many fields are data-rich but hypothesis-poor. Here, computational methods of data analysis, which may be automated, provide the means of generating novel hypotheses, especially in the post-genomic era.
authors.affiliation: Department of Chemistry, UMIST, Manchester, UK. dbk@umist.ac.uk
authors.forename: Douglas B
authors.initials: DB
authors.lastname: Kell
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Oliver
mesh_terms: D000818:Animals; D001695:Biology; D019295:Computational Biology; D019992:Databases as Topic; D006801:Humans; D008954:Models, Biological; D012586:Science / Q000639:trends*; D013223:Statistics as Topic