title: Transmission of the severe acute respiratory syndrome on aircraft.
abstract: BACKGROUND
  The severe acute respiratory syndrome (SARS) spread rapidly around the world, largely because persons infected with the SARS-associated coronavirus (SARS-CoV) traveled on aircraft to distant cities. Although many infected persons traveled on commercial aircraft, the risk, if any, of in-flight transmission is unknown.
  
  
  METHODS
  We attempted to interview passengers and crew members at least 10 days after they had taken one of three flights that transported a patient or patients with SARS. All index patients met the criteria of the World Health Organization for a probable case of SARS, and index or secondary cases were confirmed to be positive for SARS-CoV on reverse-transcriptase polymerase chain reaction or serologic testing.
  
  
  RESULTS
  After one flight carrying a symptomatic person and 119 other persons, laboratory-confirmed SARS developed in 16 persons, 2 others were given diagnoses of probable SARS, and 4 were reported to have SARS but could not be interviewed. Among the 22 persons with illness, the mean time from the flight to the onset of symptoms was four days (range, two to eight), and there were no recognized exposures to patients with SARS before or after the flight. Illness in passengers was related to the physical proximity to the index patient, with illness reported in 8 of the 23 persons who were seated in the three rows in front of the index patient, as compared with 10 of the 88 persons who were seated elsewhere (relative risk, 3.1; 95 percent confidence interval, 1.4 to 6.9). In contrast, another flight carrying four symptomatic persons resulted in transmission to at most one other person, and no illness was documented in passengers on the flight that carried a person who had presymptomatic SARS.
  
  
  CONCLUSIONS
  Transmission of SARS may occur on an aircraft when infected persons fly during the symptomatic phase of illness. Measures to reduce the risk of transmission are warranted.
authors.affiliation: International Emerging Infections Program, Centers for Disease Control and Prevention, Nonthaburi, Thailand. sco2@cdc.gov
authors.forename: Sonja J
authors.initials: SJ
authors.lastname: Olsen
authors.forename: Hsiao-Ling
authors.initials: HL
authors.lastname: Chang
authors.forename: Terence Yung-Yan
authors.initials: TY
authors.lastname: Cheung
authors.forename: Antony Fai-Yu
authors.initials: AF
authors.lastname: Tang
authors.forename: Tamara L
authors.initials: TL
authors.lastname: Fisk
authors.forename: Steven Peng-Lim
authors.initials: SP
authors.lastname: Ooi
authors.forename: Hung-Wei
authors.initials: HW
authors.lastname: Kuo
authors.forename: Donald Dah-Shyong
authors.initials: DD
authors.lastname: Jiang
authors.forename: Kow-Tong
authors.initials: KT
authors.lastname: Chen
authors.forename: Jim
authors.initials: J
authors.lastname: Lando
authors.forename: Kwo-Hsiung
authors.initials: KH
authors.lastname: Hsu
authors.forename: Tzay-Jinn
authors.initials: TJ
authors.lastname: Chen
authors.forename: Scott F
authors.initials: SF
authors.lastname: Dowell
mesh_terms: D000368:Aged; D000401:Aircraft; D018562:Disease Transmission, Infectious; D004781:Environmental Exposure; D006723:Hong Kong; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D045169:Severe Acute Respiratory Syndrome / Q000635:transmission*; D014195:Travel