title: Sequelae of syndrome X in children born small for gestational age.
abstract: OBJECTIVE
  Low birth weight is associated with the presence of syndrome X in adults. We studied the components of this syndrome in prepubertal children born SGA (small for gestational age) and children born AGA (appropriate for gestational age).
  
  
  METHODS
  Twenty-nine SGA children, age (mean +/- SD) 9.1 +/- 1.1 years and 24 AGA children, age 9.0 +/- 1.1 years were studied. Fasting serum lipid concentrations were determined. A hyperinsulinemic euglycemic clamp was performed to measure insulin sensitivity. Ambulatory monitoring was performed to obtain 24-hour recordings of blood pressure.
  
  
  RESULTS
  Prepubertal SGA children are less insulin sensitive and have a higher nighttime systolic blood pressure (SBP) after correction for BMI than children born AGA. No differences were found in lipid concentrations between the 2 groups.
  
  
  CONCLUSIONS
  Not all components of syndrome X can yet be found in 9-year-old children born SGA; follow-up of this cohort is required.
authors.affiliation: Department of Pediatrics, Research Institute for Endocrinology, Reproduction and Metabolism, VU University Medical Center (VUmc), Amsterdam, The Netherlands.
authors.forename: Margreet A
authors.initials: MA
authors.lastname: Veening
authors.forename: Mirjam M
authors.initials: MM
authors.lastname: van Weissenbruch
authors.forename: Henriette A
authors.initials: HA
authors.lastname: Delemarre-van de Waal
mesh_terms: D001724:Birth Weight; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001794:Blood Pressure; D002648:Child; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006946:Hyperinsulinism; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007328:Insulin / Q000494:pharmacology; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008055:Lipids