Central neuropeptide Y alters ethanol-induced sedation, but not ethanol intake, in C57BL/6 mice.
Recent evidence indicates that neuropeptide Y modulates neurobiologic responses to ethanol and ethanol consumption. Resistance to the sedative effects of ethanol, voluntary ethanol consumption, or both was found to be inversely related to neuropeptide Y levels in genetically manipulated rat and mouse models. More recently, intracerebroventricular infusion of neuropeptide Y reduced ethanol drinking in rats selectively bred for high ethanol preference, but not in low-ethanol-preferring or in outbred Wistar rats. In the current study, we determined whether intracerebroventricular infusion of neuropeptide Y would reduce voluntary ethanol consumption in high-ethanol-preferring, C57BL/6 mice. We also studied ethanol-induced sedation after intracerebroventricular infusion of neuropeptide Y. Pretreatment with doses of neuropeptide Y, ranging from 3.0 to 10.0 microg, significantly augmented ethanol-induced sedation without altering locomotor activity or plasma ethanol levels. However, neither a 5.0- nor a 10.0-microg dose of neuropeptide Y altered 2-h drinking of a 10% [volume/volume (vol./vol.)] ethanol solution. Consistent with genetic evidence, the results of current pharmacologic studies provide support that neuropeptide Y modulates ethanol-induced sedation.
Thiele
Todd E
TE
Department of Psychology and the Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3270, USA. thiele@unc.edu
Sparta
Dennis R
DR
Fee
Jon R
JR
Navarro
Montserrat
M
Cubero
Inmaculada
I
D000428:Alcohol Drinking / Q000235:genetics / Q000517:prevention & control; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D000431:Ethanol / Q000008:administration & dosage*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009478:Neuropeptide Y / Q000008:administration & dosage*; D012890:Sleep / Q000187:drug effects*; D013045:Species Specificity
D006993:Hypnotics and Sedatives; D009478:Neuropeptide Y; D000431:Ethanol