Benign ectopic thyroid tissue in a cutaneous location: a case report and review.
BACKGROUND
For many years, lateral, aberrant thyroid tissue in adults was a term used almost exclusively for metastatic thyroid carcinoma. However, aberrant, benign ectopic thyroid tissue does occur, and it is most commonly found as a part of the evaluation of endocrine dysfunction. Rarely, aberrant, benign ectopic thyroid presents as a primary mass.


METHODS
We present a 35-year-old female who presented for removal of a lifelong posterior lateral neck nodule.


RESULTS
Histologic examination and immunohistochemical studies confirmed the presence of aberrant, benign ectopic thyroid tissue. The patient had no endocrine problems, and she had a normally located and functioning thyroid gland.


CONCLUSIONS
This case illustrates that not all aberrant thyroid tissues in adults are malignant or associated with endocrine disorders. This case also illustrates the rare association of ectopic thyroid and a normally located and functioning thyroid gland. In this patient, a somatic mutation in a transcription factor important in thyroid migration could explain these findings.
Maino
Kim
K
Department of Dermatology, National Naval Medical Center, Bethesda, MD, USA.
Skelton
Henry
H
Yeager
Josef
J
Smith
Kathleen J
KJ
D000328:Adult; D015415:Biomarkers / Q000032:analysis; D002828:Choristoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D012871:Skin Diseases / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D013961:Thyroid Gland
D015415:Biomarkers