title: Rapid tumor death model for evaluation of new therapeutic agents for adult T-cell leukemia.
abstract: Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasm. The health of ATL patients rapidly deteriorates resulting in death; however, the induction of death in a small animal model due to tumor has not yet been reported. SCID mice, 5 weeks old, younger than those previously used, which were inoculated with ATL cells, eliminated NK cell activity and showed rapid tumor formation resulting in death. Age is the crucial factor influencing tumor formation and death in the SCID mice model for cancer.
authors.affiliation: Division of Microbiology and Genetics, Center for Animal Resources and Development, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan. ohsugi@gpo.kumamoto-u.ac.jp
authors.forename: Takeo
authors.initials: T
authors.lastname: Ohsugi
authors.forename: Kazunari
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Toshio
authors.initials: T
authors.lastname: Kumasaka
authors.forename: Takaomi
authors.initials: T
authors.lastname: Ishida
authors.forename: Ryouichi
authors.initials: R
authors.lastname: Horie
authors.forename: Toshiki
authors.initials: T
authors.lastname: Watanabe
authors.forename: Noboru
authors.initials: N
authors.lastname: Sakio
authors.forename: Toshio
authors.initials: T
authors.lastname: Fujimoto
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Toru
authors.initials: T
authors.lastname: Urano
mesh_terms: D000367:Age Factors; D000818:Animals; D001609:Beta-Globulins / Q000032:analysis / Q000235:genetics; D002472:Cell Transformation, Viral; D004273:DNA, Neoplasm / Q000032:analysis; D016356:Gene Products, tax / Q000032:analysis / Q000235:genetics; D015490:HTLV-I Infections; D015368:Human T-lymphotropic virus 1 / Q000235:genetics* / Q000276:immunology; D016867:Immunocompromised Host; D007694:Killer Cells, Natural / Q000276:immunology; D015458:Leukemia, T-Cell / Q000276:immunology / Q000401:mortality / Q000821:virology; D008297:Male; D051379:Mice; D016513:Mice, SCID; D016133:Polymerase Chain Reaction; D015996:Survival Rate; D023041:Xenograft Model Antitumor Assays
chemical_list: D001609:Beta-Globulins; D004273:DNA, Neoplasm; D016356:Gene Products, tax