title: No association between allelic variants of HOXA1/HOXB1 and autism.
abstract: Two recent studies have reported conflicting findings of association of a variant in the HOXA1 gene and autism. To try to resolve the conflict in findings, we conducted an association study in 78 Irish families of the reported DNA variants. We did not find statistically significant association between the variants and autism. Similarly there was no evidence of preferential transmission of variants from parent of either sex to affected offspring. We also report negative findings for HOXB1 variants. We conclude that the HOXA1/B1 are unlikely to be the susceptibility genes for autism in our sample.
authors.affiliation: Department of Genetics, Smurfit Institute for Genetics, Trinity College, Dublin 2, Ireland. lgallagh@tcd.ie
authors.forename: Louise
authors.initials: L
authors.lastname: Gallagher
authors.forename: Ziarih
authors.initials: Z
authors.lastname: Hawi
authors.forename: Geraldine
authors.initials: G
authors.lastname: Kearney
authors.forename: Michael
authors.initials: M
authors.lastname: Fitzgerald
authors.forename: Michael
authors.initials: M
authors.lastname: Gill
mesh_terms: D000483:Alleles; D001321:Autistic Disorder / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D007494:Ireland; D015810:Linkage Disequilibrium; D008297:Male; D009679:Nuclear Family; D014157:Transcription Factors / Q000235:genetics*; D000099261:Homeobox A1 Protein
chemical_list: D018398:Homeodomain Proteins; D014157:Transcription Factors; D000099261:Homeobox A1 Protein; C484414:HOXB13 protein, human