title: Efficiency of high-flux hemodialysis in the treatment of valproic acid intoxication.
abstract: Recently, highly efficient (i.e., high volume) dialysis systems have been successfully introduced for the treatment of critically ill patients in the intensive care unit. They also can be a safer, more effective, and less costly alternative to traditional extracorporal techniques in the treatment of severe intoxication. This holds true even if the substance to be eliminated is believed to be a poor candidate for dialysis treatment. We report a case of successful treatment of potentially life-threatening intoxication, with valproic acid (VPA) using a GENIUS batch dialysis system for combined standard and extended high-volume hemodialysis therapy. Concentration of VPA in the total collected dialysate were measured.
authors.affiliation: Division of Nephrology, Department of Clinical Chemistry, Medical School Hannover, Hannover, Germany. kielstein@yahoo.com
authors.forename: J T
authors.initials: JT
authors.lastname: Kielstein
authors.forename: A
authors.initials: A
authors.lastname: Woywodt
authors.forename: G
authors.initials: G
authors.lastname: Schumann
authors.forename: H
authors.initials: H
authors.lastname: Haller
authors.forename: D
authors.initials: D
authors.lastname: Fliser
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000506:poisoning*; D006801:Humans; D008297:Male; D006435:Renal Dialysis / Q000009:adverse effects; D013406:Suicide, Attempted; D013921:Thrombocytopenia / Q000209:etiology; D014635:Valproic Acid / Q000506:poisoning*
chemical_list: D000927:Anticonvulsants; D014635:Valproic Acid