title: Prognosis of patients with a diagnosis of fatty liver--a registry-based cohort study.
abstract: OBJECTIVE
  There are very limited data available regarding the prognosis of patients with fatty liver. We examined the overall and cause-specific mortality of fatty liver patients in a large Danish cohort.
  
  
  METHODS
  In the Danish National Registry of Patients, we identified 7,372 patients discharged with a diagnosis of fatty liver from a Danish hospital between 1977 and 1993. Causes of death were identified in the Danish Death Registry. We estimated the standardized mortality ratio by comparing with the general population.
  
  
  RESULTS
  Most patients (76%) had alcoholic fatty liver. During follow-up, 2,914 (40%) died. The commonest cause of death was hepatobiliary disease (25% of deaths). Mortality was increased 5.4-fold (95% CI 5.2-5.6) in patients with alcoholic fatty liver, and 2.6-fold (95% CI 2.4-2.9) in patients with non-alcoholic or unspecified fatty liver. Overall, in the first year of follow-up, mortality was increased more than 7-fold, almost 5-fold in the second to fifth years, and more than 3-fold after that. Mortality was similar among genders and among diabetics and non-diabetics, and remained increased after censoring patients upon diagnosis of liver cirrhosis.
  
  
  CONCLUSIONS
  The mortality of patients with a hospital discharge diagnosis of fatty liver was higher than that of the general population.
authors.affiliation: Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg Hospital, Denmark. pj@soci.au.dk
authors.forename: Peter
authors.initials: P
authors.lastname: Jepsen
authors.forename: Hendrik
authors.initials: H
authors.lastname: Vilstrup
authors.forename: Lene
authors.initials: L
authors.lastname: Mellemkjaer
authors.forename: Ane Marie
authors.initials: AM
authors.lastname: Thulstrup
authors.forename: Jørgen H
authors.initials: JH
authors.lastname: Olsen
authors.forename: John A
authors.initials: JA
authors.lastname: Baron
authors.forename: Henrik Toft
authors.initials: HT
authors.lastname: Sørensen
mesh_terms: D002423:Cause of Death; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005234:Fatty Liver / Q000175:diagnosis / Q000401:mortality*; D005235:Fatty Liver, Alcoholic / Q000175:diagnosis / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012042:Registries / Q000706:statistics & numerical data; D016019:Survival Analysis