[The role of diagnostic tests in the identification of Chlamydia trachomatis infection in reactive arthritis].
Reactive arthritis (ReA) is a sterile inflammation of the synovial membrane of one or more joints developing after urogenital or gastro-intestinal infection. The syndrome most frequently follows infection with Chlamydia trachomatis. Useful for the diagnosis can be the serological tests. At present there is the possibility to identify the specific antibodies (IgG, IgA, IgM) to Chlamydia trachomatis. The subject of the study was the group of 87 patients in age 19-78; 58 women and 29 men from whom urogenital smear and serum were tested. The control group were 30 people age 25-70 without rheumatological disorders. Chlamydia trachomatis was found in urogenital smear in 42 (48%), in 56 (64%) patients immunoglobulin IgG were positive, and immunoglobulin IgA in 16 (18%). The laboratory tests and clinical symptoms allow to make a diagnosis of ReA in 38 (43%) and possible ReA in 5 (5.7%) of patients.


CONCLUSIONS
1. There is no gold standard for the diagnosis of ReA. 2. None of the tests or the clinical symptoms alone are strong enough to make a definite diagnosis of ReA. 3. Tests to identify Chlamydia trachomatis, with respect of typical clinical symptoms are useful the diagnosis of ReA. 4. The diagnosis of ReA is most probable if we have typical clinical symptoms, clinical evidence of a preceding infection plus a positive result of serology or PCR plus positivity for HLA-B27.
Swierkot
Jerzy
J
Zakład Reumatologii AM we Wrocławiu.
Choroszy-Król
Irena
I
Marczyńska-Gruszecka
Katarzyna
K
Teryks-Wołyniec
Dorota
D
Czepułkowska
Joanna
J
Szechiński
Jacek
J
D000328:Adult; D000368:Aged; D016918:Arthritis, Reactive / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology; D002690:Chlamydia Infections / Q000175:diagnosis / Q000276:immunology / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000276:immunology* / Q000302:isolation & purification*; D005260:Female; D015796:HLA-B27 Antigen / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D000091402:Prohibitins
D015796:HLA-B27 Antigen; D007136:Immunoglobulins; C000717331:PHB2 protein, human; D000091402:Prohibitins