Radical cyclization cascade involving ynamides: an original access to nitrogen-containing heterocycles.
A radical cascade involving a 5-exo-dig cyclization followed by a 6-endo-trig radical trapping transforms ynamides into heterogeneous polycyclic compounds in good yields. This leads interestingly to the formation of isoindols, isoindolinones, and pyridoisoindolones. [reaction: see text]
Marion
Frédéric
F
Laboratoire de chimie organique, associé au CNRS, Université Pierre et Marie Curie, Tour 44-54, B.229, 4 Place Jussieu, 75252 Paris Cedex 05, France.
Courillon
Christine
C
Malacria
Max
M