title: Peripheral nerve magnetic stimulation: influence of tissue non-homogeneity.
abstract: BACKGROUND
  Peripheral nerves are situated in a highly non-homogeneous environment, including muscles, bones, blood vessels, etc. Time-varying magnetic field stimulation of the median and ulnar nerves in the carpal region is studied, with special consideration of the influence of non-homogeneities.
  
  
  METHODS
  A detailed three-dimensional finite element model (FEM) of the anatomy of the wrist region was built to assess the induced currents distribution by external magnetic stimulation. The electromagnetic field distribution in the non-homogeneous domain was defined as an internal Dirichlet problem using the finite element method. The boundary conditions were obtained by analysis of the vector potential field excited by external current-driven coils.
  
  
  RESULTS
  The results include evaluation and graphical representation of the induced current field distribution at various stimulation coil positions. Comparative study for the real non-homogeneous structure with anisotropic conductivities of the tissues and a mock homogeneous media is also presented. The possibility of achieving selective stimulation of either of the two nerves is assessed.
  
  
  CONCLUSIONS
  The model developed could be useful in theoretical prediction of the current distribution in the nerves during diagnostic stimulation and therapeutic procedures involving electromagnetic excitation. The errors in applying homogeneous domain modeling rather than real non-homogeneous biological structures are demonstrated. The practical implications of the applied approach are valid for any arbitrary weakly conductive medium.
authors.affiliation: Centre of Biomedical Engineering, Acad. G. Bonchev str. block 105, Sofia 1113, Bulgaria. ikdas@argo.bas.bg
authors.forename: Vessela T Z
authors.initials: VT
authors.lastname: Krasteva
authors.forename: Sava P
authors.initials: SP
authors.lastname: Papazov
authors.forename: Ivan K
authors.initials: IK
authors.lastname: Daskalov
mesh_terms: D002648:Child; D004056:Differential Threshold; D004558:Electric Stimulation / Q000379:methods*; D006801:Humans; D007223:Infant; D008280:Magnetics; D008475:Median Nerve / Q000502:physiology*; D008959:Models, Neurological; D014459:Ulnar Nerve / Q000502:physiology*; D014953:Wrist / Q000033:anatomy & histology