title: [Invasive pneumococcal disease in children in the Community of Valencia, Spain].
abstract: OBJECTIVE
  Pneumococcal disease is an important cause of morbidity and mortality in children. The recent authorization of the heptavalent conjugate vaccine has increased interest in this disease. The objective of this study was to identify the epidemiological and clinical characteristics of this disease, as well as its outcome in the pediatric population of the Autonomous Community of Valencia.
  
  
  METHODS
  Data were obtained from the medical records of children aged less than 15 years who were positive for pneumococcus isolation on admission to hospital between 1996 and 2000. All the public hospitals of the Autonomous Community of Valencia were included. Changes in incidence were evaluated by comparing rates and outcomes (sequelae and lethality) through frequency and age distribution.
  
  
  RESULTS
  One hundred twenty-seven cases were registered, giving a mean annual rate of 3.89/105 inhabitants aged less than 15 years. The rate was 20.14 in children aged less than 2 years. A total of 29.1% of the children had previous health problems. The main clinical manifestations included sepsis/bacteremia (38%), pneumonia (31%) and meningitis (24%). At discharge sequelae were present in 10 children, 75% of whom were aged less than 2 years. Eight children died (6.3% lethality).
  
  
  CONCLUSIONS
  In the period and region studied, pneumococcal infection was present mainly in children aged less than 2 years and in those with previous health problems. In the last few years, mortality has increased. Thus, inclusion of pneumococcal disease in the epidemiological surveillance system would be appropriate to achieve more precise estimations of its epidemiological patterns and to determine whether the conjugate vaccine represents a solution to the problems currently associated with this bacteria.
authors.affiliation: Servicio de Salud Infantil y de la Mujer. Dirección General para la Salud Pública. Conselleria de Sanitat de la Comunidad Valenciana. Valencia. Spain. mergoico@terra.es
authors.forename: M
authors.initials: M
authors.lastname: Goicoechea-Sáez
authors.forename: A M
authors.initials: AM
authors.lastname: Fullana-Montoro
authors.forename: P
authors.initials: P
authors.lastname: Momparler-Carrasco
authors.forename: M J
authors.initials: MJ
authors.lastname: Redondo-Gallego
authors.forename: J
authors.initials: J
authors.lastname: Brines-Solanes
authors.forename: F J
authors.initials: FJ
authors.lastname: Bueno-Cañigral
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011008:Pneumococcal Infections / Q000150:complications / Q000453:epidemiology*; D013030:Spain / Q000453:epidemiology