title: Novel P4 truncated tripeptidyl alpha-ketoamides as HCV protease inhibitors.
abstract: We describe herein the synthesis and evaluation of two series of P-4 truncated tripeptidyl alpha-ketoamides as HCV serine protease inhibitors. The most promising compound disclosed in this communication 7b demonstrated enzyme binding affinity (K(i)) at 0.27 uM.
authors.affiliation: Lilly Research Laboratory, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Lamar
authors.forename: Frantz
authors.initials: F
authors.lastname: Victor
authors.forename: Nancy
authors.initials: N
authors.lastname: Snyder
authors.forename: Robert B
authors.initials: RB
authors.lastname: Johnson
authors.forename: Q May
authors.initials: QM
authors.lastname: Wang
authors.forename: John I
authors.initials: JI
authors.lastname: Glass
authors.forename: Shu-Hui
authors.initials: SH
authors.lastname: Chen
mesh_terms: D000577:Amides / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D016174:Hepacivirus / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D009842:Oligopeptides / Q000737:chemistry* / Q000494:pharmacology; D012093:Replicon / Q000187:drug effects; D012697:Serine Endopeptidases / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000577:Amides; D009842:Oligopeptides; D015842:Serine Proteinase Inhibitors; D012697:Serine Endopeptidases