Transcriptional regulation of genes for enzymes of the prostaglandin biosynthetic pathway.
Numerous studies over the years have demonstrated changes in prostaglandin (PG) levels in intrauterine tissues in association with labour, and PG administration has long been used to induce delivery. While it is now widely accepted that PGs play a major role in human parturition, the complex regulation of their levels is still being elucidated, with the focus on the transcriptional control of the enzymes responsible for the various steps in PG biosynthesis and catabolism.
Lindstrom
Tamsin
T
Faculty of Medicine, Institute of Reproductive and Developmental Biology, Parturition Research Group, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK. t.lindstrom@imperial.ac.uk
Bennett
Phillip
P
D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism; D010741:Phospholipases A / Q000235:genetics* / Q000378:metabolism; D011247:Pregnancy; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics* / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis* / Q000235:genetics; D014158:Transcription, Genetic
D007527:Isoenzymes; D016328:NF-kappa B; D011453:Prostaglandins; D011451:Prostaglandin-Endoperoxide Synthases; D010741:Phospholipases A