title: Mesial temporal lobe epilepsy and hippocampal sclerosis: cognitive function assessment in Hispanic patients.
abstract: OBJECTIVE
  The goal of this study was to assess the cognitive function status in patients with mesial temporal lobe epilepsy and hippocampal sclerosis (TLE+HS) to determine their cognitive function profile and to correlate material-specific memory deficits with HS laterality diagnosed by MRI.
  
  
  METHODS
  Seventy-one patients were assessed with a neuropsychological protocol that includes IQ, attention, handedness, verbal memory, visual memory, language, and the executive function. chi(2) and correlation tests were used.
  
  
  RESULTS
  Memory impairment was found in 46 patients (66%): patients without any memory deficit (n=25), patients with verbal memory deficit (n=21), patients with visual memory deficit (n=17), patients with deficit for both types of memory (n=8). Correlation between MRI lesion and memory was 66%. Language was impaired in 33 patients (46%). Eighteen patients (25%) had a deficit of the executive function.
  
  
  CONCLUSIONS
  Patients with TLE+HS presented with a deficit in material-specific episodic memory correlating in large proportion with HS lateralization. We also found language and executive function impairments.
authors.affiliation: Epilepsy Center, Neurology Division, Ramos Mejia Hospital, Av. Scalabrini Ortiz 2330 1 degrees E, Capital Federal, CP: 1425, Buenos Aires, Argentina. silviaoddo@hotmail.com
authors.forename: Silvia
authors.initials: S
authors.lastname: Oddo
authors.forename: Oddo
authors.initials: O
authors.lastname: Silvia
authors.forename: Patricia
authors.initials: P
authors.lastname: Solís
authors.forename: Solís
authors.initials: S
authors.lastname: Patricia
authors.forename: Damián
authors.initials: D
authors.lastname: Consalvo
authors.forename: Consalvo
authors.initials: C
authors.lastname: Damián
authors.forename: Brenda
authors.initials: B
authors.lastname: Giagante
authors.forename: Giagante
authors.initials: G
authors.lastname: Brenda
authors.forename: Walter
authors.initials: W
authors.lastname: Silva
authors.forename: Silva
authors.initials: S
authors.lastname: Walter
authors.forename: Luciana
authors.initials: L
authors.lastname: D'Alessio
authors.forename: D'Alessio
authors.initials: D
authors.lastname: Luciana
authors.forename: Estela
authors.initials: E
authors.lastname: Centurión
authors.forename: Centurión
authors.initials: C
authors.lastname: Estela
authors.forename: Patricia
authors.initials: P
authors.lastname: Saidón
authors.forename: Saidón
authors.initials: S
authors.lastname: Patricia
authors.forename: Silvia
authors.initials: S
authors.lastname: Kochen
authors.forename: Kochen
authors.initials: K
authors.lastname: Silvia
mesh_terms: D000328:Adult; D001288:Attention; D016009:Chi-Square Distribution; D003072:Cognition Disorders / Q000209:etiology*; D004833:Epilepsy, Temporal Lobe / Q000150:complications*; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus; D006630:Hispanic or Latino; D006801:Humans; D007360:Intelligence; D007802:Language; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D008569:Memory Disorders; D008875:Middle Aged; D009483:Neuropsychological Tests; D011340:Problem Solving; D012598:Sclerosis / Q000150:complications*; D013223:Statistics as Topic; D014705:Verbal Behavior