title: Semiconductor quantum dots for photodynamic therapy.
abstract: The applicability of semiconductor QDs in photodynamic therapy (PDT) was evaluated by studying the interaction between CdSe QDs with a known silicon phthalocyanine PDT photosensitizer, Pc4. The study revealed that the QDs could be used to sensitize the PDT agent through a fluorescence resonance energy transfer (FRET) mechanism, or interact directly with molecular oxygen via a triplet energy-transfer process (TET). Both mechanisms result in the generation of reactive singlet oxygen species that can be used for PDT cancer therapy.
authors.affiliation: Center for Chemical Dynamics and Nanomaterials Research, Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, USA.
authors.forename: Anna C S
authors.initials: AC
authors.lastname: Samia
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Chen
authors.forename: Clemens
authors.initials: C
authors.lastname: Burda
mesh_terms: D019187:Cadmium Compounds / Q000737:chemistry; D031541:Fluorescence Resonance Energy Transfer; D007211:Indoles / Q000737:chemistry*; D010100:Oxygen / Q000737:chemistry*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry*; D045663:Quantum Dots; D018036:Selenium Compounds / Q000737:chemistry; D012666:Semiconductors
chemical_list: D019187:Cadmium Compounds; D007211:Indoles; D017319:Photosensitizing Agents; D018036:Selenium Compounds; C107448:phthalocyanine Pc 4; D010100:Oxygen