A mitochondrial DNA variant associated with left ventricular hypertrophy in diabetes.
Diabetes was reported to be associated with a mitochondrial (mt) DNA mutation at 3243 and variants at 1310, 1438, 3290, 3316, 3394, 12,026, 15,927, and 16,189. Among these mtDNA abnormalities, those at 3243, 3316, 15,927, and 16,189 were also suggested to cause cardiomyopathies. We investigated the prevalence of such mtDNA abnormalities in 68 diabetic patients with LV hypertrophy (LVH), 100 without LVH, and 100 controls. Among the 9 mtDNA abnormalities, those at 3243, 3316, and 15,927 tended to be more prevalent in diabetic patients with LVH than in those without LVH (1%, 1%, and 4% vs. 0%, 0%, and 0%). Notably, the variant at 16,189 was more prevalent in diabetic patients with LVH than without LVH (46% vs. 24%, [Formula: see text] ). The odds ratio for LVH was 3.0 (95% CI, 1.5-6.1) for the 16,189 variant. A common mtDNA variant at 16,189 was found to be associated with LVH in diabetic patients.
Momiyama
Yukihiko
Y
The Heart Institute of Japan, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Furutani
Michiko
M
Suzuki
Yoshihiko
Y
Ohmori
Reiko
R
Imamura
Shin-ichiro
S
Mokubo
Atsuko
A
Asahina
Takayuki
T
Murata
Chisato
C
Kato
Kiyoe
K
Anazawa
Sonoko
S
Hosokawa
Kazuhiro
K
Atsumi
Yoshihito
Y
Matsuoka
Kempei
K
Kimura
Mitsuru
M
Kasanuki
Hiroshi
H
Ohsuzu
Fumitaka
F
Matsuoka
Rumiko
R
D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000097:blood / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D014644:Genetic Variation; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged
D004272:DNA, Mitochondrial