title: Protonophoric and uncoupling activity of royleanones from Salvia officinalis and euvimals from Eucalyptus viminalis.
abstract: The mechanism of action of quinones from the roots of Salvia officinalis L. (royleanones) and terpenoid phenolaldehydes from the leaves of Eucalyptus viminalis Labill. (euvimals) was studied. Royleanones and euvimals displayed marked protonophoric activity on artificial bilayer lipid membranes in vitro, and exerted an uncoupling action on oxidative phosphorylation in isolated rat liver mitochondria. The results suggest that biological membranes are the primary targets of royleanones and euvimals, and the protonophoric activity may contribute to the cytotoxicity and antimicrobial properties of these compounds.
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, Russia. spiridonov@cber.fda.gov
authors.forename: Nikolay A
authors.initials: NA
authors.lastname: Spiridonov
authors.forename: Vladimir V
authors.initials: VV
authors.lastname: Arkhipov
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Foigel
authors.forename: Liudmila D
authors.initials: LD
authors.lastname: Shipulina
authors.forename: Maria G
authors.initials: MG
authors.lastname: Fomkina
mesh_terms: D045784:Abietanes / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D005052:Eucalyptus; D006801:Humans; D008051:Lipid Bilayers / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D018517:Plant Roots; D051381:Rats; D027543:Salvia officinalis; D013729:Terpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D014475:Uncoupling Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D045784:Abietanes; D008051:Lipid Bilayers; D010936:Plant Extracts; D013729:Terpenes; D014475:Uncoupling Agents; C103399:royleanone