Stomach myoelectrical response of patients with gastroesophageal reflux disease receiving omeprazole treatment.
OBJECTIVE
Proton pump inhibitor treatment is effective for gastroesophageal reflux disease (GERD). It is unknown whether these agents effect any change in the stomach myoelectricity of GERD patients. Electrogastrographic (EGG) recording was used to study the probable effect of omeprazole on GERD patients.


METHODS
Nineteen endoscopically confirmed GERD patients and 38 dyspepsia-free controls were invited to receive EGG recording. After daily omeprazole treatment for 4 weeks, the symptomatic response of GERD patients was scaled, healing of erosive esophagitis was endoscopically assessed, and EGG recording was repeated for comparison.


RESULTS
Before treatment, GERD patients and controls displayed similar dominant frequency, whereas the former had higher dominant power compared with controls, either in fasting (29.2 +/- 6.0 dB compared with 25.3 +/- 3.8 dB, P < 0.01) or postprandial (31.9 +/- 5.6 dB compared with 27.7 +/- 3.8 dB, P < 0.001) recording. They also had diminished percentile normal rhythm (2-4 c.p.m.), irrespective of fasting (40.2 +/- 14.5% compared with 65.8% +/- 23.5%, P < 0.001) or postprandial (47.5 +/- 23.3% compared with 77.9 +/- 16.8%, P < 0.001) recording. After omeprazole treatment, healing was achieved in 12 patients (63.2%). Among the abnormal EGG parameters, only the postprandial percentile normal rhythm was restored (47.5 +/- 23.3% compared with 65.2 +/- 20.8%, P < 0.01).


CONCLUSIONS
Gastroesophageal reflux disease patients may have obvious dysrhythmia and higher myoelectrical power. Effective omeprazole treatment only improves the postprandial myoelectrical regularity, whereas abnormal EGG parameters remain impaired.
Chang
Full-Young
FY
Division of Gastroenterology, Taipei Veterans General Hospital and School of Medicine National Yang Ming University, and Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan.
Lu
Ching-Liang
CL
Chen
Chih-Yen
CY
Luo
Jiing-Chyuan
JC
Jiun
Kang Lih
KL
Lee
Shou-Dong
SD
Wu
Han Chang
HC
D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002681:China; D005215:Fasting / Q000502:physiology; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016065:Myoelectric Complex, Migrating / Q000187:drug effects*; D009853:Omeprazole / Q000494:pharmacology* / Q000627:therapeutic use; D019518:Postprandial Period / Q000502:physiology; D013270:Stomach / Q000187:drug effects* / Q000503:physiopathology
D000897:Anti-Ulcer Agents; D009853:Omeprazole