title: Induction of beta-chemokine secretion by human brain microvessel endothelial cells via CD40/CD40L interactions.
abstract: beta-chemokines play an important role during the course of central nervous system (CNS) inflammation. Using primary cultures of human cerebral microvascular endothelial cells, we detected increased monocyte chemoattractant protein-1 (MCP-1) and regulated upon activation normal T cell expressed and secreted (RANTES) production following incubation with soluble CD40L. These results suggest a potential mechanism by which activated CD40L positive T cells may enhance beta-chemokine expression and thus influence the recruitment of mononuclear cells across the human blood-brain barrier.
authors.affiliation: Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Vancouver General Hospital and the University of British Columbia, 855 West 12th Avenue, Vancouver, BC, Canada V5Z 1M9.
authors.forename: Kakuri M
authors.initials: KM
authors.lastname: Omari
authors.forename: Raymond
authors.initials: R
authors.lastname: Chui
authors.forename: Katerina
authors.initials: K
authors.lastname: Dorovini-Zis
mesh_terms: D001921:Brain / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D019013:CD40 Antigens / Q000378:metabolism* / Q000502:physiology; D023201:CD40 Ligand / Q000378:metabolism* / Q000502:physiology; D018932:Chemokine CCL2 / Q000494:pharmacology; D018946:Chemokine CCL5 / Q000494:pharmacology; D019742:Chemokines, CC / Q000378:metabolism*; D042783:Endothelial Cells / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008833:Microcirculation / Q000276:immunology / Q000378:metabolism
chemical_list: D019013:CD40 Antigens; D018932:Chemokine CCL2; D018946:Chemokine CCL5; D019742:Chemokines, CC; D023201:CD40 Ligand