New efficient procedure for the use of diethoxyphosphoryl as a protecting group in the synthesis of polyazamacrocycles. Preparation of polyazacyclophanes derived from resorcinol.
The synthesis of polyazamacrocycles containing an electron-rich aromatic subunit derived from resorcinol is described. The reported synthetic procedure is based on the use of diethoxyphosphoryl (Dep) as an amine protecting group. The new conditions employed for the cyclization reaction allow for a generalized use of Dep in the synthesis of polyazamacrocycles.
Burguete
M Isabel
MI
Departament de Química Inorgànica i Orgànica, ESTCE, Universitat Jaume I, E-12080 Castellón, Spain.
López-Diago
Laura
L
García-España
Enrique
E
Galindo
Francisco
F
Luis
Santiago V
SV
Miravet
Juan F
JF
Sroczynski
Dariusz
D
D000588:Amines / Q000138:chemical synthesis; D001372:Aza Compounds / Q000138:chemical synthesis*; D003500:Cyclization; D006844:Hydrocarbons, Cyclic / Q000138:chemical synthesis*; D012118:Resorcinols / Q000737:chemistry*
D000588:Amines; D001372:Aza Compounds; D006844:Hydrocarbons, Cyclic; D012118:Resorcinols; C031389:resorcinol