Effect of naltrexone administration on short-term memory in chronically ethanol-treated outbred rats.
OBJECTIVE
The purpose of this study was to evaluate the effect of naltrexone treatment for 21 consecutive days on short-term memory in ethanol-preferring and non-preferring outbred rats.


METHODS
Ethanol preferring, non-preferring and control Wistar rats were treated with naltrexone [0.1 mg/kg intraperitoneally (i.p.)] for 21 consecutive days. Short-term memory was assessed by using an olfactory social recognition test.


RESULTS
A single administration of naltrexone (0.1 mg/kg i.p.) to non-ethanol-treated animals facilitated social memory, whereas the drug did not affect short-term memory in either group of chronically ethanol-treated rats. Multiple naltrexone treatment also lowered alcohol intake in ethanol-preferring rats.


CONCLUSIONS
Naltrexone-ethanol interaction does not seem to produce any negative effect on the short-term memory in outbred rats.
Okulicz-Kozaryn
I
I
Department of Pharmacology, University of Medical Sciences, Poznan, Poland.
Mikolajczak
P
P
Kaminska
E
E
Kaminska
I
I
Szulc
M
M
Bobkiewicz-Kozlowska
T
T
D000704:Analysis of Variance; D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage*; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects*; D009271:Naltrexone / Q000008:administration & dosage / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D009292:Narcotic Antagonists; D000431:Ethanol; D009271:Naltrexone