title: [Effect of inhaled terbutaline sulphate (dry powder, Turbuhaler and nebulizer solution) in children with acute asthma].
abstract: Forty seven children (6-14 years), with an acute mild or moderate attack of asthma (clinical score 3 or FEV1 > 50% of the predicted), were treated with terbutaline sulphate, by inhalation route with a dry powder inhaler (Turbuhaler - 0,5 mg - group T; N=27, or by a nebulizer 1% solution-in saline-compressed air (6 l/min.) group S; N=20. The children were evaluated at 5, 15, 25 and 30 minutes after the initial treatment. In both groups a significant fall of the clinical score (starting at 15 minutes) (p < 0.05) and a significant improvement of the FEV(1), VC and FEF25-75% (starting at 5 minutes), were observed (p < 0.05). There were no significant changes in heart rates, respiratory rates and blood pressure (p > 0.05). At the end of the first treatment, the number of patients with a FEV(1) < 80% was similar in both groups (T = 13/27 and S = 10/20). The same treatment was repeated, and all the children showed a marked improvement, except for one boy of the group T was hospitalized. In conclusion, children with mild or moderate acute attacks of asthma can be treated up to a week with an inhalation of dry powder, resulting in adequate bronchodilatation without important side effects.
authors.affiliation: Disciplina de Alergia, Imunologia Clínica e Reumatologia, Departmento de Pediatria, Universidade Federal de São Paulo.
authors.forename: D
authors.initials: D
authors.lastname: Solé
authors.forename: M C
authors.initials: MC
authors.lastname: Rizzo
authors.forename: A F
authors.initials: AF
authors.lastname: Pimentel
authors.forename: F
authors.initials: F
authors.lastname: Sano
authors.forename: B A
authors.initials: BA
authors.lastname: Barreto
authors.forename: N F
authors.initials: NF
authors.lastname: Wandalsen
authors.forename: C K
authors.initials: CK
authors.lastname: Naspitz