[Comparative analysis of the efficacy of iodine prophylaxis in pregnant women living in endemic goiter areas].
OBJECTIVE
To assess efficacy of different methods of iodine prophylaxis in pregnant women living in conditions of goiter endemia.


METHODS
Standard clinical, laboratory and device tests for iodine deficiency according to WHO criteria were made in 156 pregnant women living in the territory affected by goiter endemia. Of them, 121 examinees had no thyroid pathology, 35 ones had diffuse euthyroid goiter. All of them received different kinds of iodine prophylaxis.


RESULTS
The occurrence of neonatal TTH values over 5 iU/l in neonates born by mothers free of thyroid pathology on potassium iodide prophylaxis when pregnant was 9.1%. This is much lower than in conventional iodine prophylaxis--17.24% (p < 0.01). A comparative analysis of the efficacy of potassium iodide-200 in pregnant women with diffuse euthyroid goiter and its combination with L-thyroxine has shown that by the effect on lessening frequency of neonatal TTH over 5 iU/l the above schemes do not differ significantly, thyroid reduction is more prominent in pregnant women on thyroxine with potassium iodide.


CONCLUSIONS
The index of neonatal TTH is an objective criterium to control efficacy of different methods of iodine prophylaxis in pregnancy.
Turovinina
E F
EF
Suplotova
L A
LA
Khramova
E B
EB
Smetanina
S A
SA
D005260:Female; D006043:Goiter, Endemic / Q000151:congenital / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D007231:Infant, Newborn; D011193:Potassium Iodide / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000188:drug therapy*; D011256:Pregnancy Outcome; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000000981:diagnostic imaging; D013972:Thyrotropin / Q000097:blood; D014463:Ultrasonography
D011193:Potassium Iodide; D013972:Thyrotropin