[Effect of aminotriazole on the activity of catalase and glucose-6-phosphate dehydrogenase in tissues of two frog species--Rana ridibunda and Rana esculenta].
Changes of the activity of catalase and glucose-6-phosphate dehydrogenase (G6PDH) during 48 hrs after intraperitoneal injection of 1.0, 0.5 and 0.1 mg aminotriazole per gram of body weight of two frog species as well as catalase inhibition by aminotriazole in vitro were investigated. Both aminotriazole concentration and species affiliation affected the catalase inhibition. The sensitivity of catalase from different tissues was decreased in the order: liver--kidney--lung--muscle--brain. The constant of half inhibition of lung catalase was significantly lower than that of liver and kidney catalase. The activity of G6PDH of AMT-treated frogs R. esculenta was higher comparing to control group. Possible ways of compensation of antioxidant defense under catalase inhibition are discussed.
Lushchak
O V
OV
Vassyl Stefanyk Precarpathian University, Ivano-Frankivsk, Ukraine.
Bahniukova
T V
TV
Lushchak
V I
VI
D000640:Amitrole / Q000494:pharmacology*; D000818:Animals; D002374:Catalase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors*; D007274:Injections, Intraperitoneal; D009928:Organ Specificity; D011893:Rana esculenta; D011895:Rana ridibunda; D013045:Species Specificity
D004791:Enzyme Inhibitors; D005954:Glucosephosphate Dehydrogenase; D002374:Catalase; D000640:Amitrole