title: Reduction in dentin permeability using mildly supersaturated calcium phosphate solutions.
abstract: Treatments that obturate dentin tubules have been used for reducing dentin hypersensitivity. The objective of this study was to determine the effects of multiple treatments with a mildly supersaturated calcium phosphate solution on the hydraulic conductance (Lp) of partially occluded dentin discs in vitro. The treatment solution contained 6.5 mmoll(-1) each of calcium and phosphate, 0.25 mmoll(-1) fluoride, 30 mmoll(-1) KCl, and 50 mmoll(-1) HEPES buffer (pH adjusted to 7.0). The mean baseline Lp (in microlcm(-2)min(-1) H(2)O cm(-1)) was 0.108+/-0.041 (mean +/- S.D.; n=9, microlcm(-2)min(-1) H(2)O cm(-1) = 10.20 microlcm(-2)min(-1)KPa(-1)) and after five consecutive treatments, the mean relative Lp, presented as percentage of baseline, were 71+/-11, 58+/-10, 46+/-18, 40+/-14, and 25+/-10, respectively. The Lp values of the baseline and treatment groups were significantly (P<0.05) different. Consecutive treatments appeared effective in further reducing Lp of dentin discs.
authors.affiliation: American Dental Association Health Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Cherng
authors.forename: L C
authors.initials: LC
authors.lastname: Chow
authors.forename: S
authors.initials: S
authors.lastname: Takagi
mesh_terms: D002130:Calcium Phosphates / Q000737:chemistry / Q000494:pharmacology*; D003806:Dentin Permeability / Q000187:drug effects*; D003807:Dentin Sensitivity / Q000517:prevention & control; D006801:Humans; D016369:Smear Layer; D012996:Solutions / Q000737:chemistry / Q000494:pharmacology
chemical_list: D002130:Calcium Phosphates; D012996:Solutions; C020243:calcium phosphate