title: Cloning, characterization and comparative analysis of pig plasma apolipoprotein A-IV.
abstract: Pig apolipoprotein (apo) A-IV cDNA was cloned, characterized and compared to the human ortholog. Mature porcine apo A-IV consists of 362 amino acids and displays a 75.6% sequence identity with human protein. Pig apo A-IV is the smallest reported mammalian apo A-IV because it lacks the repeated motifs of glutamine and glutamic acid at the carboxyl terminus. A phylogenic tree of apo A-IV mammalian proteins reveals that porcine apo A-IV is more closely related to humans and primates than to rodents. This protein is highly hydrophobic and is mainly associated with lipoproteins.
authors.affiliation: Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Veterinaria, Universidad de Zaragoza, Miguel Servet 177, E-50013 Zaragozza, Spain.
authors.forename: María A
authors.initials: MA
authors.lastname: Navarro
authors.forename: Sergio
authors.initials: S
authors.lastname: Acín
authors.forename: María
authors.initials: M
authors.lastname: Iturralde
authors.forename: Lucía
authors.initials: L
authors.lastname: Calleja
authors.forename: Ricardo
authors.initials: R
authors.lastname: Carnicer
authors.forename: Mario A
authors.initials: MA
authors.lastname: Guzmán-García
authors.forename: Nieves
authors.initials: N
authors.lastname: González-Ramón
authors.forename: Pedro
authors.initials: P
authors.lastname: Mata
authors.forename: Beatriz
authors.initials: B
authors.lastname: Isabel
authors.forename: Clemente J
authors.initials: CJ
authors.lastname: López-Bote
authors.forename: Fermín
authors.initials: F
authors.lastname: Lampreave
authors.forename: Andrés
authors.initials: A
authors.lastname: Piñeiro
authors.forename: Jesús
authors.initials: J
authors.lastname: Osada
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001054:Apolipoproteins A / Q000097:blood / Q000737:chemistry / Q000235:genetics*; D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry / Q000235:genetics; D057927:Hydrophobic and Hydrophilic Interactions; D008969:Molecular Sequence Data; D010802:Phylogeny; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D013552:Swine / Q000235:genetics*
chemical_list: D001054:Apolipoproteins A; D018076:DNA, Complementary; C022205:apolipoprotein A-IV