[Effects of Semen Sojae Preparatum on lipid metabolism in ovariectomized rat].
OBJECTIVE
To investigate the antiatherosclerotic effect of Semen Sojae Preparatum (SSP) and its mechanism.


METHODS
48 rats were randomly divided into sham operation group (sham), ovariectomized group (OVX) and three doses of OVX + SSP groups. SSP was given to OVX + SSP groups 2 weeks after ovariectomy. The levels of serum lipids and lipid peroxidation were detected after 12 weeks treatment.


RESULTS
SSP lowered serum oxidized-low density lipoprotein cholesterol (OX-LDL, P < 0.01), triglyceride (TG, P < 0.01) and malondialdehyde (MDA, P < 0.05 or P < 0.01), and enhanced serum high density lipoprotein cholesterol (HDL-c, P < 0.05 or P < 0.01), polipoprotein A I (apo-AI, P < 0.01) and superoxide dismutase (SOD, P < 0.01) activity.


CONCLUSIONS
SSP had effects on regulating lipid and antioxidation. Therefore, it might inhibit atherosclerosis in ovariectomy rats.
Wang
Xinguo
X
Traditional Chinese Medicine College, Hebei Medical University, Shijiazhuang 050091.
Ge
Xizhen
X
Bai
Xia
X
Song
Cuimiao
C
Niu
Liying
L
Xu
Huazhou
H
D000818:Animals; D001161:Arteriosclerosis / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D010052:Ovariectomy; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013025:Glycine max / Q000737:chemistry*
D004365:Drugs, Chinese Herbal