[Extracellular matrix of the umbilical cord vein in EPH gestosis and fibroblast growth factor].
It was found in our previous studies that EPH gestosis is accompanied by an extensive remodeling of the extracellular matrix of the umbilical cord. Studies were performed on the umbilical cord veins of 10 control and 10 newborns delivered by mothers with EPH gestosis. It was decided to determine umbilical cord vein ability to bind of labeled (125J)-basic fibroblast growth factor (bFGF), and FGF content by Western immunoblot and ELISA methods. Our experiments indicated that the extracts of umbilical cord vein contain endogenous bFGF and several soluble FGF-binding compounds of different molecular weight. It is of interest that EPH gestosis is associated with a decrease in bFGF content. It seems be possible that the decrease of bFGF amount may be one of the factors, which constrain the biosynthesis of collagen in EPH gestosis umbilical cord vein wall.
Jaworski
Stefan
S
Kliniki Ginekologii AM w Białymstoku.
Romanowicz
Lech
L
Wolańska
Małgorzata
M
Sobolewski
Krzysztof
K
D015153:Blotting, Western; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005109:Extracellular Matrix / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D012307:Risk Factors; D014471:Umbilical Veins / Q000378:metabolism*
D016222:Fibroblast Growth Factor 2