title: Dinucleotide repeat polymorphism in interferon-gamma gene is not associated with sporadic Alzheimer's disease.
abstract: Various factors have been suggested to participate in Alzheimer's disease (AD) pathology, and some inflammatory cytokines may play an important role in the development of AD. Interferon-gamma (IFNG), an important pro-inflammatory cytokine, is encoded by a single gene mapped to chromosome 12, one of the candidate locus of AD. The first intron in the IFNG gene represents a CA repeat polymorphism that is possible to affect the IFNG secretion dose. We speculate that the polymorphism may have some roles on the inflammatory process and the pathologic change in AD, so we analyzed the IFNG gene polymorphism in 199 Japanese AD patients and 225 Japanese controls. There were no significant differences in allele frequency between the AD and control groups. We conclude that IFNG gene polymorphism is not associated with development of AD.
authors.affiliation: Third Department of Internal Medicine, Hiroshima University School of Medicine, Hiroshima, Japan.
authors.forename: Masaya
authors.initials: M
authors.lastname: Oda
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Maruyama
authors.forename: Yuishin
authors.initials: Y
authors.lastname: Izumi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Morino
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Torii
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Nakamura
authors.forename: Hideshi
authors.initials: H
authors.lastname: Kawakami
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D018900:Dinucleotide Repeats / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D007371:Interferon-gamma