title: Mutant p53 protein in the serum of patients with cervical carcinoma: correlation with the level of serum epidermal growth factor receptor and prognostic significance.
abstract: We have previously reported that the serum level of epidermal growth factor receptor (EGFR) was significantly elevated in 38 cervical carcinoma patients. The levels of mutant p53 protein were determined in the serum of the same cohort (invasive or recurrent carcinoma: 26, carcinoma in situ (CIS): 12) and 18 controls using ELISA. The median serum level for mutant p53 in cervical carcinoma patients (0.11 ng/ml; range, 0-2.66 ng/ml) demonstrated no significant difference compared to that of controls (0.14 ng/ml; range, 0-0.34 ng/ml) (P=0.324). Serum mutant p53 showed positive elevation in 5 patients with invasive or recurrent carcinoma (19%) and 1 with CIS (8%). A significant correlation was found between EGFR and mutant p53 levels (r=0.668; P<0.0001). In invasive or recurrent cervical carcinoma, positive mutant p53 was significantly associated with poor overall survival in both univariate (P=0.035) and multivariate (P=0.046) analysis, while increased level of EGFR did not show prognostic significance (P=0.755). Serum mutant p53 could have potential usefulness as a biological marker of cervical carcinoma for prediction of prognosis and follow-up after treatment.
authors.affiliation: Department of Obstetrics and Gynecology, Kuro Hospital, Korea University College of Medicine, 80 Kuro-Dong, Kuro-Gu, 152-050 Seoul, South Korea.
authors.forename: Min-Jeong
authors.initials: MJ
authors.lastname: Oh
authors.forename: Jin-Hyuk
authors.initials: JH
authors.lastname: Choi
authors.forename: Yong Ho
authors.initials: YH
authors.lastname: Lee
authors.forename: Jae Kwan
authors.initials: JK
authors.lastname: Lee
authors.forename: Joon Young
authors.initials: JY
authors.lastname: Hur
authors.forename: Yong Kyun
authors.initials: YK
authors.lastname: Park
authors.forename: Kyu Wan
authors.initials: KW
authors.lastname: Lee
authors.forename: Soo Yong
authors.initials: SY
authors.lastname: Chough
authors.forename: Ho-Suk
authors.initials: HS
authors.lastname: Saw
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000097:blood / Q000401:mortality; D066246:ErbB Receptors / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009154:Mutation; D011379:Prognosis; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000097:blood*; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000401:mortality
chemical_list: D016159:Tumor Suppressor Protein p53; D066246:ErbB Receptors