title: The exploitation of distinct recognition receptors in dendritic cells determines the full range of host immune relationships with Candida albicans.
abstract: Dendritic cells (DC) sense saprophytic yeast and pathogenic, filamentous forms of Candida albicans in a specific way, resulting in disparate patterns of DC and T(h) cell activation. Using human and murine DC, such disparate patterns could be traced to the exploitation of distinct recognition receptors. Although usage of mannose receptors led to protective type 1 responses in mice, entry through Fcgamma receptors was responsible for suppression of mannose receptor-dependent reactivity, onset of type 2 responses and associated pathology. As the usage of distinct receptors selectively occurred with yeast or hyphal forms of the fungus, these findings suggest that the responsibility for pathogenicity of C. albicans is shared by the organism and DC, with implications for fungal virulence, immunity and vaccine development.
authors.affiliation: Department of Experimental Medicine and Biochemical Science, University of Perugia, 06122 Perugia, Italy. lromani@unipg.it
authors.forename: Luigina
authors.initials: L
authors.lastname: Romani
authors.forename: Claudia
authors.initials: C
authors.lastname: Montagnoli
authors.forename: Silvia
authors.initials: S
authors.lastname: Bozza
authors.forename: Katia
authors.initials: K
authors.lastname: Perruccio
authors.forename: Antonio
authors.initials: A
authors.lastname: Spreca
authors.forename: Paola
authors.initials: P
authors.lastname: Allavena
authors.forename: Sjef
authors.initials: S
authors.lastname: Verbeek
authors.forename: Richard A
authors.initials: RA
authors.lastname: Calderone
authors.forename: Francesco
authors.initials: F
authors.lastname: Bistoni
authors.forename: Paolo
authors.initials: P
authors.lastname: Puccetti
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000276:immunology* / Q000472:pathogenicity / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology* / Q000469:parasitology; D005434:Flow Cytometry; D006790:Host-Parasite Interactions / Q000276:immunology*; D006801:Humans; D007118:Immunoassay; D051379:Mice; D009895:Opsonin Proteins / Q000378:metabolism; D010587:Phagocytosis / Q000276:immunology; D011971:Receptors, Immunologic
chemical_list: D009895:Opsonin Proteins; D011971:Receptors, Immunologic