title: CO2 production during acute infection in malnourished Malawian children.
abstract: OBJECTIVE
  This study tested the hypotheses that the rate of CO2 production is less in marasmic children with acute infection when compared to well-nourished children, but greater when compared to uninfected marasmic children.
  
  
  METHODS
  A descriptive comparison of children aged 12-60 months who had their rates of CO2 production measured using a stable isotope tracer dilution method while receiving feedings. Body mass index (BMI) was the best measure of lean body mass available in this study.
  
  
  METHODS
  Queen Elizabeth Central Hospital, Blantyre, Malawi.
  
  
  METHODS
  A total of 56 children were studied, 28 with marasmus and acute infection, 16 with marasmus, and 12 well nourished with acute infection. Those with acute infection had malaria, pneumonia, or sepsis.
  
  
  RESULTS
  Well-nourished children with acute infection produced more CO2 than marasmic children (344+/-60 vs 225+/-65 mmol CO2/h, mean+/-s.d., P<0.001; 24.2+/-4.6 vs 18.4+/-5.4 mmol CO2/BMI h, P=0.001). However, the rate of CO2 production in marasmic children with acute infection was not greater than in uninfected marasmic children (225+/-65 vs 228+/-61 mmol CO2/h). The observed rate of CO2 production was greater than that which could be produced from the dietary intake alone (29.6 vs. 25.8 mmol CO2/kg h).
  
  
  CONCLUSIONS
  Marasmic children do not increase energy expenditure in response to acute infection, as well-nourished children do. Dietary energy provided to marasmic children should be at least 420 kJ/kg day.
authors.affiliation: Department of Pediatrics, Washington University School of Medicine. St Louis, MO, USA. manary@kids.wustl.edu
authors.forename: M J
authors.initials: MJ
authors.lastname: Manary
authors.forename: K E
authors.initials: KE
authors.lastname: Yarasheski
authors.forename: R
authors.initials: R
authors.lastname: Berger
authors.forename: R L
authors.initials: RL
authors.lastname: Broadhead
mesh_terms: D015992:Body Mass Index; D001944:Breath Tests; D002245:Carbon Dioxide / Q000378:metabolism*; D002675:Child, Preschool; D002149:Energy Intake; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D007223:Infant; D007239:Infections / Q000150:complications* / Q000378:metabolism*; D008295:Malawi; D009751:Nutritional Requirements; D010084:Oxidation-Reduction; D011502:Protein-Energy Malnutrition / Q000150:complications* / Q000378:metabolism*
chemical_list: D002245:Carbon Dioxide