title: Secondary retinal changes associated with choroidal naevi and melanomas documented by optical coherence tomography.
abstract: OBJECTIVE
  To establish the characteristics of secondary retinal changes associated with the presence of choroidal melanomas and choroidal naevi as documented by optical coherence tomography (OCT).
  
  
  METHODS
  Twenty patients with untreated choroidal melanoma and 40 patients with presumed choroidal naevi managed by regular observation were included in the study. OCT scans across the surface of the tumour and surrounding tissue were acquired for all participants. The appearance of retinal tissue on the OCT scans was considered to be abnormal if it did not display the well defined band structure characteristic of normal tissue on OCT scans.
  
  
  RESULTS
  Serous retinal detachments were observed in all patients with choroidal melanoma and 18 out of 20 also had abnormal retinal structure or intra-retinal splitting in the tissue overlying the tumour. Out of the 40 patients with presumed choroidal naevi, 12 had serous detachments and three had either abnormal retinal structure or intra-retinal splitting overlying the lesion.
  
  
  CONCLUSIONS
  Secondary retinal changes associated with choroidal lesions can be documented by OCT. These changes were observed in most patients with choroidal melanoma included in the study group but were far less prevalent in the patients with presumed choroidal naevi. OCT is also able to identify the presence of small serous detachments before they become clinically visible. Follow up of these patients is required to determine whether the OCT results may be of use in the differential diagnosis of small choroidal lesions.
authors.affiliation: Tennent Institute of Ophthalmology, Gartnavel General Hospital, 1053 Great Western Road, Glasgow G12 0YN, Scotland, UK.
authors.forename: S
authors.initials: S
authors.lastname: Muscat
authors.forename: S
authors.initials: S
authors.lastname: Parks
authors.forename: E
authors.initials: E
authors.lastname: Kemp
authors.forename: D
authors.initials: D
authors.lastname: Keating
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002830:Choroid Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000150:complications*; D008875:Middle Aged; D009506:Nevus / Q000150:complications*; D011446:Prospective Studies; D012163:Retinal Detachment / Q000175:diagnosis / Q000209:etiology; D012164:Retinal Diseases / Q000175:diagnosis / Q000209:etiology*; D041623:Tomography, Optical Coherence / Q000379:methods