title: [Progression to IDDM and islet cell antibodies (ICA; ICA-CF)].
abstract: We have followed eight first-degree relatives of IDDM patients (insulin-dependent, type I diabetes) attending the outpatient diabetes clinic at the State University of Rio de Janeiro for three years, all of them with positive islet cell antibodies (ICA and/or ICA-CF). Three out of eight relatives less than fifteen years old have subsequently progressed to overt Insulin-Dependent Diabetes Mellitus (IDDM) 12, 21 and 8 months after the first positive autoantibodies detection. Four relatives have remained with ICA and/or ICA-CF positive, and in another one the reaction became negative during the observation period. A positive correlation has been found between high titles of ICA (> or = 1/16) and development of IDDM. We have concluded from our prospective study during three years that of our antibody-positive relatives, 37.5 % have developed overt diabetes, all of them being less than fifteen years old, with high titles of ICA and ICA-CF positive.
authors.affiliation: ciplina de Diabetes e Metabologia, UERJ, Rio de Janeiro, RJ.
authors.forename: M B
authors.initials: MB
authors.lastname: Gomes
authors.forename: G R
authors.initials: GR
authors.lastname: Silva
authors.forename: E N
authors.initials: EN
authors.lastname: Sarno
authors.forename: L M
authors.initials: LM
authors.lastname: Vieira
authors.forename: E P
authors.initials: EP
authors.lastname: Marques
authors.forename: A R
authors.initials: AR
authors.lastname: Chacra