title: The technology behind Colgate Total Advanced Fresh.
abstract: In the early 1990s, a breakthrough toothpaste, Colgate Total, was launched with documented long-lasting activity against plaque, gingivitis, calculus, tooth decay, and bad breath. The technology behind this toothpaste is the combination of triclosan, a polyvinylmethylether/maleic acid copolymer, and sodium fluoride. The copolymer ensures maximal oral retention and subsequent release of the antibacterial triclosan. Effective levels of triclosan have been observed in the oral cavity 12 hours after brushing the teeth, allowing prolonged control of oral bacteria that may cause the most common dental problems, including bad breath. Similarly, the enhanced retention of triclosan to oral surfaces after using this revolutionary toothpaste for up to 2 years has led to significantly reduced incremental coronal caries compared to an American Dental Association-Approved anticavity fluoride toothpaste. Furthermore, significantly less calcium remained in dental plaque after brushing the teeth with the triclosan/copolymer toothpaste, resulting in the formation of less tartar. In keeping with the multiple oral health benefits provided by Colgate Total, consumers are now offered a new dentifrice, Colgate Total Advanced Fresh, which provides the numerous therapeutic and esthetic benefits that are the hallmark of Colgate Total. The new dentifrice, which contains an impactful breath-freshening flavor, has been documented to provide sustained control of bad breath over 12 hours.
authors.affiliation: Colgate-Palmolive Company Technology Center, Piscataway, New Jersey, USA.
authors.forename: Malcolm I
authors.initials: MI
authors.lastname: Williams
authors.forename: Diane
authors.initials: D
authors.lastname: Cummins
mesh_terms: D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000378:metabolism; D002327:Cariostatic Agents / Q000737:chemistry; D045424:Complex Mixtures; D003802:Dentifrices / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004338:Drug Combinations; D005421:Flavoring Agents; D005459:Fluorides; D006209:Halitosis / Q000628:therapy*; D006801:Humans; D008298:Maleates / Q000737:chemistry / Q000494:pharmacology; D009055:Mouth / Q000382:microbiology; D011095:Polyethylenes / Q000737:chemistry / Q000494:pharmacology; D012824:Silicic Acid; D012822:Silicon Dioxide; D012969:Sodium Fluoride / Q000737:chemistry; D013457:Sulfur Compounds / Q000378:metabolism; D014100:Toothpastes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D014260:Triclosan / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D045424:Complex Mixtures; D003802:Dentifrices; D004338:Drug Combinations; D005421:Flavoring Agents; D008298:Maleates; D011095:Polyethylenes; D013457:Sulfur Compounds; D014100:Toothpastes; C546060:hydrated silica gel-based toothpaste; D012824:Silicic Acid; D014260:Triclosan; D012822:Silicon Dioxide; D012969:Sodium Fluoride; C043105:poly(methyl vinyl ether-co-maleic anhydride); D005459:Fluorides