Secrets of insulin and IGF-1 regulation of insulin secretion revealed.
There has been ongoing controversy over the respective roles of insulin-like growth factor-1 receptors and insulin receptors in controlling insulin release from beta-cells of the pancreas. An acute knock-down experiment exploiting small interfering RNA approaches provides a resolution: both are required.
Shepherd
Peter R
PR
Department of Biochemistry and Molecular Biology, University College London, Gower St, London WC1E 6BT, UK. p.shepherd@biochem.ucl.ac.uk
D000818:Animals; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D051379:Mice; D010179:Pancreas / Q000378:metabolism*; D034622:RNA Interference; D017526:Receptor, IGF Type 1 / Q000235:genetics / Q000502:physiology*; D011972:Receptor, Insulin / Q000235:genetics / Q000502:physiology*
D007328:Insulin; D017526:Receptor, IGF Type 1; D011972:Receptor, Insulin