[Study on the relationship between glutathione S transferase mu gene deletion and leukemia in workers exposed to benzene].
OBJECTIVE
To study the relationship between glutathione S transferase M1(GST mu) gene deletion and leukemia in workers exposed to benzene.


METHODS
A matched population-based case-control survey with multivariate Logistic regression analysis was conducted in this study.


RESULTS
In the population of 34 patients and their matched controls, the absence of the GST mu genotype conferred odds ratio of 3.6. It suggested that GST mu was an important determinant of heterogeneity in individual susceptibility to leukemia associated with exposure to benzene. The single-variance analysis indicated that these markedly significant factors were GST mu gene deletion, GST mu isoenzyme activity, duration of exposure, GST isoenzyme activity, smoking quantity and average concentration of benzene in workshop air. The multivariate analysis indicated that these markedly significant factors were GST mu gene deletion, duration of exposure to benzene and GST mu isoenzyme activity.


CONCLUSIONS
GST mu gene deletion may be associated with increased risk of leukemia in workers exposed to benzene and is one of genetically determined factors.
Wang
Wenjing
W
Shanghai Center for Disease Control and Prevention, Shanghai 200336, China.
Li
Changji
C
Long
Yunfang
Y
Zhan
Chenglie
C
Xiang
Cuiqin
C
D001554:Benzene / Q000633:toxicity*; D016022:Case-Control Studies; D017353:Gene Deletion; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D007938:Leukemia / Q000201:enzymology / Q000209:etiology / Q000235:genetics*; D016015:Logistic Models; D015999:Multivariate Analysis; D016273:Occupational Exposure / Q000009:adverse effects*
D001554:Benzene; D005982:Glutathione Transferase