title: [Coexistence of VIN and vulvar invasive cancer with intraepithelial neoplasia and invasive carcinoma of the cervix and/or vagina, and HPV infection of the low female genital tract].
abstract: BACKGROUND
  A frequency of VIN and vulvar carcinoma is continuously increasing, especially in young women in whom the changes are often multifocal.
  
  
  OBJECTIVE
  Evaluation of VIN and vulvar carcinoma coexistence with intraepithelial as well as invasive changes within vagina and uterine cervix and estimation of the frequency of HPV infection accompanying these changes.
  
  
  METHODS
  Study group was consisted of 389 women aged 22-92 y. Cytologic, colposcopic examinations of the entire low genital tract and diagnosis of HPV infection with use of DNA HPV hybridization technique were performed in all cases. There were 148 (38.0%) cases of vulvar changes in women below 45 yrs of life, and 241 (62.0%) cases in older patients. HPV infection was diagnosed in 91 (61.5%) young women and in 41 (17.0%) women over 45 yrs. Intraepithelial neoplasia or invasive cancer of vagina and/or uterine cervix were diagnosed in 16 (10.8%) cases of young patients, and HPV infection of high oncological potential was diagnosed in 13 (81.3%) of these patients.
  
  
  CONCLUSIONS
  There is a high percent of coexistence of intraepithelial as well as invasive changes of the vulva, vagina and uterine cervix which mostly coexist with HPV infection of high oncological potential. These data suggest an important role of HPV infection in low female genital tract carcinogenesis and obliges to a precise examination of the entire low female genital tract, especially in young women.
authors.affiliation: Katedry Ginekologii i Połoznictwa Kliniki Ginekologii, Połoznictwa i Onkologii Collegium Medicum Uniwersytetu Jagiellońskiego.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Adamek
authors.forename: Andrzej
authors.initials: A
authors.lastname: Szczudrawa
authors.forename: Antoni
authors.initials: A
authors.lastname: Basta
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000150:complications* / Q000821:virology; D015344:DNA Probes, HPV; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000150:complications* / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000150:complications* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000150:complications* / Q000821:virology; D014625:Vaginal Neoplasms / Q000150:complications* / Q000821:virology; D014846:Vulvar Neoplasms / Q000150:complications* / Q000821:virology; D002578:Uterine Cervical Dysplasia / Q000150:complications
chemical_list: D015344:DNA Probes, HPV