title: Blood glucose is correlated with cerebrospinal fluid neurotransmitter metabolites.
abstract: Medications which influence monoaminergic neurotransmission can also have an effect on glucose regulation. In order to better understand the role of central monoaminergic neurotransmission in blood glucose homeostasis, we explored the relation between blood glucose and cerebrospinal fluid metabolite concentrations of monoaminergic neurotransmitters. Under stringently controlled resting conditions, we measured fasting blood glucose and performed lumbar punctures on 41 healthy participants. Peripheral blood glucose concentrations were significantly correlated with the cerebrospinal fluid concentrations of the dopamine metabolite, homovanillic acid and the noradrenaline metabolite, 3-methoxy-4-hydroxyphenylglycol. These correlations may represent a homeostatic relation between brain neurotransmitter activity and blood glucose.
authors.affiliation: Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892-1610, USA. Umhau@nih.gov
authors.forename: John C
authors.initials: JC
authors.lastname: Umhau
authors.forename: Sarah G
authors.initials: SG
authors.lastname: Petrulis
authors.forename: Rosalyn
authors.initials: R
authors.lastname: Diaz
authors.forename: Robert
authors.initials: R
authors.lastname: Rawlings
authors.forename: David T
authors.initials: DT
authors.lastname: George
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D012701:Serotonin; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine; D009638:Norepinephrine; D006719:Homovanillic Acid