Sequelae of syndrome X in children born small for gestational age.
OBJECTIVE
Low birth weight is associated with the presence of syndrome X in adults. We studied the components of this syndrome in prepubertal children born SGA (small for gestational age) and children born AGA (appropriate for gestational age).


METHODS
Twenty-nine SGA children, age (mean +/- SD) 9.1 +/- 1.1 years and 24 AGA children, age 9.0 +/- 1.1 years were studied. Fasting serum lipid concentrations were determined. A hyperinsulinemic euglycemic clamp was performed to measure insulin sensitivity. Ambulatory monitoring was performed to obtain 24-hour recordings of blood pressure.


RESULTS
Prepubertal SGA children are less insulin sensitive and have a higher nighttime systolic blood pressure (SBP) after correction for BMI than children born AGA. No differences were found in lipid concentrations between the 2 groups.


CONCLUSIONS
Not all components of syndrome X can yet be found in 9-year-old children born SGA; follow-up of this cohort is required.
Veening
Margreet A
MA
Department of Pediatrics, Research Institute for Endocrinology, Reproduction and Metabolism, VU University Medical Center (VUmc), Amsterdam, The Netherlands.
van Weissenbruch
Mirjam M
MM
Delemarre-van de Waal
Henriette A
HA
D001724:Birth Weight; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D001794:Blood Pressure; D002648:Child; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006946:Hyperinsulinism; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007328:Insulin / Q000494:pharmacology; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids