title: [Primary malignant lymphoma arising from the nipple and areolar area of the breast].
abstract: A 56-year-old woman noticed soreness and swelling in the right nipple. Two weeks later, she noticed a mass in the outer lower region of the right areolar area, which was excised and the pathology of which was consistent with diffuse large B cell lymphoma (DLBCL). She was admitted when the right nipple mass was noted to be increasing, and was diagnosed as having stage I lymphoma. Her nipple mass was excised, and the pathology was consistent with DLBCL. CHOP therapy was administered three times and she was judged as having complete remission. Malignant lymphoma accounts for 0.15-0.17% of primary breast malignancies. Though the nipple and areolar area seem to be a rare primary site, this should be recognized as a sentinel zone for malignant lymphoma.
authors.affiliation: Clinical Hematology and Clinical Diagnostics, Osaka City University, Graduate School of Medicine.
authors.forename: Takahiko
authors.initials: T
authors.lastname: Nakane
authors.forename: Takahisa
authors.initials: T
authors.lastname: Yamane
authors.forename: Hisako
authors.initials: H
authors.lastname: Shibata
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Aoyama
authors.forename: Taro
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Chikahiko
authors.initials: C
authors.lastname: Sakamoto
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Nakamae
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Terada
authors.forename: Kensuke
authors.initials: K
authors.lastname: Ohta
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hino
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000473:pathology*; D008875:Middle Aged; D009558:Nipples; D011239:Prednisolone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone