title: Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors.
abstract: Several chemical modifications in the N(1)-benzenesulfonamide ring of celecoxib are presented. The series with a hydroxymethyl group adjacent to the sulfonamide was found to be the most potent modification that yielded many compounds selectively active against COX-2 enzyme in vitro.
authors.affiliation: Discovery Chemistry, Discovery Research-Dr. Reddy's Laboratories Ltd, Bollaram Road, 500 049, Miyapur, Hyderabad, India. sunilkkumarsingh@drreddys.com
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Singh
authors.forename: P Ganapati
authors.initials: PG
authors.lastname: Reddy
authors.forename: K Srinivasa
authors.initials: KS
authors.lastname: Rao
authors.forename: Braj B
authors.initials: BB
authors.lastname: Lohray
authors.forename: P
authors.initials: P
authors.lastname: Misra
authors.forename: Shaikh A
authors.initials: SA
authors.lastname: Rajjak
authors.forename: Yeleswarapu K
authors.initials: YK
authors.lastname: Rao
authors.forename: A
authors.initials: A
authors.lastname: Venkateswarlu
mesh_terms: D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry*; D013449:Sulfonamides / Q000737:chemistry*; D000096926:Benzenesulfonamides
chemical_list: D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000096926:Benzenesulfonamides