title: Fourier transform ion cyclotron resonance mass spectrometry using atmospheric pressure photoionization for high-resolution analyses of corticosteroids.
abstract: Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS) was coupled with atmospheric pressure photoionization (APPI) for the first time and used for the analysis of several corticosteroids.1 The analytes showed excellent response using APPI when compared with both electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI). APPI has the advantage of requiring less heat for desolvation, resulting in less thermal degradation of the analytes and higher signal-to-noise than APCI. In terms of ultimate sensitivity, APPI is more efficient than either ESI or APCI for the analysis of corticosteroids. With some compounds, the high-resolution capability of FTICRMS was necessary to obtain an accurate mass due to contributions of the M(+.) (13)C isotope in the [M+H](+) ion peak.
authors.affiliation: Pfizer Global Research and Development, La Jolla Laboratories, San Diego, CA 92121, USA. michael.grieg@pfizer.com
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Greig
authors.forename: Ben
authors.initials: B
authors.lastname: Bolaños
authors.forename: Terri
authors.initials: T
authors.lastname: Quenzer
authors.forename: Jessica M R
authors.initials: JM
authors.lastname: Bylund
mesh_terms: D000305:Adrenal Cortex Hormones / Q000032:analysis* / Q000737:chemistry*; D001274:Atmospheric Pressure; D017357:Cyclotrons / Q000295:instrumentation; D000431:Ethanol / Q000737:chemistry; D010777:Photochemistry / Q000379:methods*; D017785:Photons; D011786:Quality Control; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012997:Solvents / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D014867:Water / Q000737:chemistry
chemical_list: D000305:Adrenal Cortex Hormones; D012997:Solvents; D014867:Water; D000431:Ethanol