title: [Examining the effect of amiodarone on the lung: data of prospective study].
abstract: Amiodarone (A) that belongs to Class III antiarrhythmics is a highly antiarrhythmic agents not only in treating, but in preventing various cardiac arrhythmias. However, its prolonged treatment may have an adverse life-threatening effect on the lung in 1-10% of patients. The purpose of our study was to verify the safe effect of A on the lung. Forty-one patients receiving A were examined in the period of its saturation and for the following 6 months. A hundred and forty-nine patients treated with its maintaining doses long (for 11 years) were also studied. Lung X-ray films and spirograms were repeated every 1-3 months at the beginning of therapy and then every 6 months. Side pulmonary effects were not observed. The findings may lead to the conclusion that comparatively small maintaining doses of A are safe for the patient.
authors.affiliation: Intensive Care Medicine Clinic, Kaunas University of Medicine, Institute of Cardiology, Russian Cardiology Research-Production Complex, Ministry of Health of the Russian Federation.
authors.forename: D I
authors.initials: DI
authors.lastname: Reĭngardene
authors.forename: A P
authors.initials: AP
authors.lastname: Azarvichene
authors.forename: I Z
authors.initials: IZ
authors.lastname: Korobkova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000503:physiopathology; D008171:Lung Diseases / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011859:Radiography; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000517:prevention & control; D012129:Respiratory Function Tests; D012131:Respiratory Insufficiency / Q000139:chemically induced / Q000517:prevention & control; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000889:Anti-Arrhythmia Agents; D000638:Amiodarone