Strategies for cancer gene therapy.
Gene therapy offers new opportunities for cancer treatment and prevention through the use of targeted, relatively nontoxic treatments that can identify, disable, and destroy malignant cells. This article reviews the principles behind oncogene inactivation, tumor suppressor gene replacement, inhibition of angiogenesis, immunopotentiation, molecular chemotherapy, and addition of drug resistance genes. The adcantages and limitations of viral and nonviral vectors for delivery of the therapeutic genes are presented.
Hughes
Rhiannon M
RM
Department of Oncology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. rhughesb@ucalgary.ca
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D018390:Gene Targeting; D016147:Genes, Tumor Suppressor; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D009857:Oncogenes
D000276:Adjuvants, Immunologic