title: Autoantibodies to GAD65 and IA-2 antibodies are increased, but not tissue transglutaminase (TTG-Ab) in type 2 diabetes mellitus (T2DM) patients from South India.
abstract: The frequency of autoantibody-positve T2DM patients identified as LADA was shown to be high in T2DM patients from Eastern India. In this study, we measured autoantibodies to GAD65, IA-2, and TTG in T2DM patients from Southern India. Our results show that either GAD65 or IA-2 was present in 30% of T2DM patients (n = 155) and in 3% of controls for GAD65 and 1% of controls for IA-2 (n = 105). TTG-Ab was not increased in T2DM patients compared to controls. Our results suggest that LADA is more frequent in Southern Indians than in European Caucasians, but not as high as in Eastern Indians.
authors.affiliation: Department of Molecular Medicine, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden. sanjeevi.carani@molmed.ki.se
authors.forename: C B
authors.initials: CB
authors.lastname: Sanjeevi
authors.forename: M
authors.initials: M
authors.lastname: Balaji
authors.forename: V
authors.initials: V
authors.lastname: Balaji
authors.forename: V
authors.initials: V
authors.lastname: Seshiah
mesh_terms: D001323:Autoantibodies / Q000097:blood*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology*; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007194:India; D007527:Isoenzymes / Q000276:immunology*; D011503:Transglutaminases / Q000276:immunology*
chemical_list: D001323:Autoantibodies; C096322:ICA512 autoantibody; D007527:Isoenzymes; D011503:Transglutaminases; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2