Mechanisms underlying cancer-induced symptoms.
In addition to the physical and emotional suffering induced by the diagnosis of cancer, patients are subjected to additional discomfort and suffering from symptoms induced by both the disease and its treatment. While an increasing amount of clinical and basic science research has focused on these issues, our understanding of the mechanisms underlying cancer-related symptoms remains incomplete. This article summarizes what is known about the mechanisms underlying the common symptoms of pain, cachexia, nausea and vomiting, dyspnea, fatigue and mood disorders, as well as the implications of these findings for therapeutic intervention.
Gutstein
Howard B
HB
Departments of Anesthesiology and Molecular Genetics, University of Texas, MD Anderson Cancer Center, Houston, Texas 77030-4009, USA. hgutstein@mdanderson.org
D000970:Antineoplastic Agents / Q000009:adverse effects; D002100:Cachexia / Q000188:drug therapy / Q000209:etiology; D004417:Dyspnea / Q000188:drug therapy / Q000209:etiology; D005221:Fatigue / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D019964:Mood Disorders / Q000188:drug therapy / Q000209:etiology; D009325:Nausea / Q000188:drug therapy / Q000209:etiology; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy*; D010146:Pain / Q000188:drug therapy / Q000209:etiology; D014839:Vomiting / Q000188:drug therapy / Q000209:etiology
D000970:Antineoplastic Agents