title: Lack of association of HLA class I genes and TNF alpha-308 polymorphism in toluene diisocyanate-induced asthma.
abstract: BACKGROUND
  Toluene diisocyanate (TDI)-induced asthma is a common cause of occupational asthma and it affects 5-15% of the exposed population suggesting an underlying genetic susceptibility.
  
  
  METHODS
  To investigate the role of genetic factors in the development of TDI-induced asthma, we analyzed the distribution of human leukocyte antigen (HLA) class I genes and of tumor necrosis factor (TNF)-alpha A-308G polymorphism in 142 patients with TDI-induced asthma and in 50 asymptomatic exposed subjects.
  
  
  RESULTS
  Neither the distribution of HLA class I antigens nor the distribution of TNF-alpha A-308G polymorphism was different between patients with TDI-induced asthma and asymptomatic exposed subjects.
  
  
  CONCLUSIONS
  These results suggest that HLA class I antigens and TNF-alpha A-308G are not associated with susceptibility or resistance to the development of TDI-induced asthma.
authors.affiliation: Section of Respiratory Diseases, Department of Clinical and Experimental Medicine,University of Padua, Padua, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Beghé
authors.forename: M
authors.initials: M
authors.lastname: Padoan
authors.forename: C T
authors.initials: CT
authors.lastname: Moss
authors.forename: S J
authors.initials: SJ
authors.lastname: Barton
authors.forename: J W
authors.initials: JW
authors.lastname: Holloway
authors.forename: S T
authors.initials: ST
authors.lastname: Holgate
authors.forename: W M
authors.initials: WM
authors.lastname: Howell
authors.forename: C E
authors.initials: CE
authors.lastname: Mapp
mesh_terms: D000328:Adult; D001249:Asthma / Q000139:chemically induced / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000235:genetics; D011110:Polymorphism, Genetic; D011336:Probability; D011379:Prognosis; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D015395:Histocompatibility Antigens Class I; D014409:Tumor Necrosis Factor-alpha; D014051:Toluene 2,4-Diisocyanate