title: A comparison of 8% and 12% sevoflurane for inhalation induction in adults.
abstract: Sevoflurane is a non-pungent volatile anaesthetic agent with a low blood-gas solubility coefficient. It has been studied in concentrations of up to 8% for induction of anaesthesia. Previous work has suggested that there may be a ceiling effect with increasing concentration of sevoflurane above 6%, but there are no published studies using 12% sevoflurane. This study compared 8 and 12% sevoflurane to induce anaesthesia in adults. Sevoflurane was administered using two adapted datum vaporisers with the interlock removed. Induction with 12% sevoflurane compared to 8% sevoflurane produced a significant decrease in the time to achieve central pupils, corresponding to surgical anaesthesia and the third part of Guedel's stage 3 of anaesthesia (mean time (SD) 201 s (81) and 247 s (39), respectively, p < 0.05). Twelve-percent sevoflurane produced a similar stable cardiovascular profile to 8% sevoflurane, and there was no increase in respiratory complications.
authors.affiliation: Department of Anaesthetics, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XW, UK. godwinn1@cf.ac.uk
authors.forename: N
authors.initials: N
authors.lastname: Goodwin
authors.forename: A E
authors.initials: AE
authors.lastname: Campbell
authors.forename: J E
authors.initials: JE
authors.lastname: Hall
authors.forename: S
authors.initials: S
authors.lastname: Plummer
authors.forename: M
authors.initials: M
authors.lastname: Harmer
mesh_terms: D000328:Adult; D018685:Anesthetics, Inhalation / Q000008:administration & dosage* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage* / Q000494:pharmacology; D008875:Middle Aged; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane