Clinical gene therapy for brain tumors. Liposomal delivery of anticancer molecule to glioma.
Liposomes are one of the most promising delivery systems for genes, proteins, and other biological molecules and they are expected to become a new therapeutic tool for the treatment of brain tumors, especially malignant gliomas. Until now, transfer of anticancer molecules using liposomes has been studied by a lot of investigators and it has been found to induce regression of experimental gliomas, resulting in establishing some original and effective therapies. Gene therapy using cationic liposomes is also one of them. Here we introduce the advanced medicine for brain tumors using liposomes containing some anticancer molecules (for example, gene, antibody, antisense, or magnetite), based on our basic and clinical research.
Yoshida
Jun
J
Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. jyoshida@med.nagoya-u.ac.jp
Mizuno
Masaaki
M
D000328:Adult; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000628:therapy*; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D015316:Genetic Therapy / Q000379:methods*; D005910:Glioma / Q000628:therapy*; D006801:Humans; D016899:Interferon-beta / Q000008:administration & dosage / Q000235:genetics; D008081:Liposomes
D000970:Antineoplastic Agents; D008081:Liposomes; D016899:Interferon-beta