title: Cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa.
abstract: The cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa was investigated. Goniothalamin showed potent cytotoxicity with LC50 values (5.03 microg/mL) comparable with the reference standard agent, gallic acid. It also showed weak antibacterial and significant antifungal activity against a wide range of gram positive and gram negative bacteria and fungi. The antibacterial (minimum inhibitory concentration) effect against Bacillus cereus and Shigella shiga was found to be 64 microg/mL.
authors.affiliation: Centre for Phytochemistry, Southern Cross University, Lismore, NSW 2480, Australia. mamosaddik@yahoo.com
authors.forename: M Ashik
authors.initials: MA
authors.lastname: Mosaddik
authors.forename: M Ekramul
authors.initials: ME
authors.lastname: Haque
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001156:Artemia / Q000187:drug effects; D001409:Bacillus cereus / Q000187:drug effects*; D019662:Cucurbitaceae; D004305:Dose-Response Relationship, Drug; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007928:Lethal Dose 50; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011753:Pyrones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012760:Shigella / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts; D011753:Pyrones; C103280:goniothalamin