title: Polymer-induced structural changes in lecithin/sodium dodecyl sulfate-based multilamellar vesicles.
abstract: Aqueous concentrated lecithin mixtures (asolectin from soybean) show typical lamellar liquid crystalline behavior and the individual lamellae tend to form spherical supramolecular structures, i.e., multilamellar vesicles. When part of the lecithin is replaced by the anionic surfactant sodium dodecyl sulfate (SDS), the compact multilamellar vesicles disappear and the viscosity decreases. By adding poly(diallyldimethylammonium chloride) (PDADMAC) to the lecithin/SDS system, the formation of multilamellar vesicles can be induced again and the viscosity increases. However, one characteristic feature of these polymer-modified systems is a temperature-dependent phase transition from a compact multilamellar vesicle phase to a more swollen liquid crystalline phase. The polymer-modified multilamellar compact vesicles are of interest for utilization as new thermosensitive drug delivery systems.
authors.affiliation: Institut für Chemie, Universität Potsdam, Karl-Liebknecht-Str. 24/25, Haus 25, 14476 Golm, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Robertson
authors.forename: Thomas
authors.initials: T
authors.lastname: Hellweg
authors.forename: Brigitte
authors.initials: B
authors.lastname: Tiersch
authors.forename: Joachim
authors.initials: J
authors.lastname: Koetz
mesh_terms: D002152:Calorimetry, Differential Scanning; D002412:Cations; D004305:Dose-Response Relationship, Drug; D004573:Electrolytes; D008051:Lipid Bilayers / Q000737:chemistry; D008854:Microscopy, Electron; D009502:Neutrons; D010713:Phosphatidylcholines / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry; D011095:Polyethylenes / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D012542:Scattering, Radiation; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry*; D013025:Glycine max; D013696:Temperature; D013816:Thermodynamics
chemical_list: D002412:Cations; D004573:Electrolytes; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D010743:Phospholipids; D011095:Polyethylenes; D011108:Polymers; D000644:Quaternary Ammonium Compounds; C041004:poly-N,N-dimethyl-N,N-diallylammonium chloride; D012967:Sodium Dodecyl Sulfate