Effect of angiotensin-converting enzyme insertion/deletion polymorphism DD genotype on high-frequency heart rate variability in African Americans.
Seventy-nine African-American participants in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) pilot study were genotyped for the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and had spectral power of their high-frequency (HF) heart rate variability (HRV) determined by fast-Fourier transformation. HF HRV was highest in II, intermediate in ID, and lowest in DD (II vs DD, p <0.043) genotypes, thus making an association of the ACE I/D DD genotype with decreased HF HRV that is consistent with the hypothesis that the DD genotype confers susceptibility to increased cardiovascular risk. The urban African-American population we studied had a particularly high cardiovascular risk, and these findings suggest that ACE I/D genotypes may modify that risk.
Thayer
Julian F
JF
National Institute on Aging Intramural Research Program, the National Center on Minority Health and Health Disparities, National Institutes of Health, Bethesda, Maryland, USA.
Merritt
Marcellus M
MM
Sollers
John J
JJ
Zonderman
Alan B
AB
Evans
Michele K
MK
Yie
Sue
S
Abernethy
Darrell R
DR
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D001741:Black or African American / Q000235:genetics*; D000367:Age Factors; D005260:Female; D005583:Fourier Analysis; D005838:Genotype; D006339:Heart Rate / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010865:Pilot Projects; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012737:Sex Factors
D000319:Adrenergic beta-Antagonists; D007703:Peptidyl-Dipeptidase A