title: Population-wide infant screening for HLA-based type 1 diabetes risk via dried blood spots from the public health infrastructure.
abstract: The frequency of type 1 diabetes mellitus (T1DM)-associated HLA DQ alleles in the U.S. Pacific Northwest is as high as in Scandinavia, which has the highest T1DM incidence in the world. The high regional rate of islet autoimmunity observed among DPT-1 relatives supports this notion. Fortunately, Washington State archives dried blood spots after legislature-mandated newborn screening. The Diabetes Evaluation in Washington (DEW-IT) study aims to show that population-based prospective prediction of T1DM by HLA genotype screening followed by autoantibody surveillance can be performed within the public health infrastructure.
authors.affiliation: Pacific Northwest Research Institute, Seattle, Washington, USA. ewion@prni.org
authors.forename: Emily
authors.initials: E
authors.lastname: Wion
authors.forename: Michael
authors.initials: M
authors.lastname: Brantley
authors.forename: Jeff
authors.initials: J
authors.lastname: Stevens
authors.forename: Susan
authors.initials: S
authors.lastname: Gallinger
authors.forename: Hui
authors.initials: H
authors.lastname: Peng
authors.forename: Michael
authors.initials: M
authors.lastname: Glass
authors.forename: William
authors.initials: W
authors.lastname: Hagopian
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D005260:Female; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D015997:Neonatal Screening / Q000706:statistics & numerical data*; D011446:Prospective Studies; D015980:Public Health Practice; D012307:Risk Factors; D014861:Washington / Q000453:epidemiology
chemical_list: D006683:HLA-DQ Antigens