title: Epstein-Barr virus-related lymph node lesion resembling autoimmune disease-like clinicopathological findings in elderly patients. Report of three cases.
abstract: Three cases of Epstein-Barr virus (EBV)-related lymphoproliferative disorders in elderly patients showing autoimmune disease-associated lymphadenopathy-like clinicopathological findings have been reported. Clinically, they were characterized by systemic lymphadenopathy, "B" symptoms, polyclonal hypergammaglobulinemia, elevated serum LDH and transient presence of various autoantibodies, and absence of atypical lymphocytosis in peripheral blood. One case was associated with idiopathic thrombocytopenic purpura. The clinical course was self-limiting. Histologically, they exhibited numerous lymphoid follicles with hyperplastic germinal centers and atypical interfollicular widening with prominent vascular proliferation. In the paracortical area, there was a mixed infiltrate comprising small to medium-sized lymphocytes and plasma cells, and variable numbers of eosinophils and T- and B-immunoblasts. In situ hybridization demonstrated a varying number of EBV-infected lymphocytes in the germinal center as well as in the interfollicular area. Polymerase chain reaction demonstrated that neither clonal rearrangement of T-cell receptor gamma-gene nor immunoglobulin heavy-chain rearrangement was detected in two of the cases examined. Although acute EBV infection rarely occurs in older adults, EBV related to reactive lymphoproliferative disorder should be added to the differential diagnosis of autoimmune disease-associated lymphadenopathy and node-based peripheral T-cell lymphoma in elderly patients.
authors.affiliation: Department of Pathology and Clinical Laboratories, Gunma Cancer Center Hospital, Ohta, Japan. mkojima@gunma-cc.jp
authors.forename: Masaru
authors.initials: M
authors.lastname: Kojima
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yamane
authors.forename: Hideaki
authors.initials: H
authors.lastname: Itoh
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Shiro
authors.initials: S
authors.lastname: Sugihara
authors.forename: Nobuhide
authors.initials: N
authors.lastname: Masawa
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D001402:B-Lymphocytes / Q000473:pathology; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000175:diagnosis; D007119:Immunoblastic Lymphadenopathy / Q000175:diagnosis; D007074:Immunoglobulin G / Q000097:blood; D017403:In Situ Hybridization; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology* / Q000821:virology*; D018655:Lymphocyte Count; D008232:Lymphoproliferative Disorders / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000175:diagnosis; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D000914:Antibodies, Viral; D001323:Autoantibodies; D007074:Immunoglobulin G; D007770:L-Lactate Dehydrogenase