Effect of statins on the progression of bioprosthetic aortic valve degeneration.
To date, there is no proved medical therapy able to significantly reduce the degenerative process of biologic prosthetic aortic valves. It has recently been suggested that statins may reduce the progression of native aortic valve stenosis. We examined the effect of statin treatment on bioprosthetic aortic valve degeneration and found a beneficial effect of statins in slowing bioprosthetic degeneration.
Antonini-Canterin
Francesco
F
Unità Operativa di Cardiologia, A.R.C., Azienda Ospedaliera S. Maria degli Angeli, Pordenone, Italy. cardiologia@aopn.fvg.it
Zuppiroli
Alfredo
A
Popescu
Bogdan A
BA
Granata
Gianluca
G
Cervesato
Eugenio
E
Piazza
Rita
R
Pavan
Daniela
D
Nicolosi
Gian Luigi
GL
D000368:Aged; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000601:surgery; D001022:Aortic Valve Insufficiency / Q000209:etiology / Q000517:prevention & control*; D001024:Aortic Valve Stenosis / Q000150:complications / Q000517:prevention & control*; D000069059:Atorvastatin; D001705:Bioprosthesis; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000150:complications; D005260:Female; D006350:Heart Valve Prosthesis; D006538:Heptanoic Acids / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000150:complications; D008297:Male; D017035:Pravastatin / Q000627:therapeutic use; D011475:Prosthesis Failure; D011758:Pyrroles / Q000627:therapeutic use; D012189:Retrospective Studies; D019821:Simvastatin / Q000627:therapeutic use; D016896:Treatment Outcome; D014463:Ultrasonography
D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin; D019821:Simvastatin; D017035:Pravastatin