Music therapy for mood disturbance during hospitalization for autologous stem cell transplantation: a randomized controlled trial.
BACKGROUND
High-dose therapy with autologous stem cell transplantation (HDT/ASCT) is a commonly used treatment for hematologic malignancies. The procedure causes significant psychological distress and no interventions have been demonstrated to improve mood in these patients. Music therapy has been shown to improve anxiety in a variety of acute medical settings. In the current study, the authors determined the effects of music therapy compared with standard care on mood during inpatient stays for HDT/ASCT.


METHODS
Patients with hematologic malignancy admitted for HDT/ASCT at two sites (Memorial Sloan-Kettering Cancer Center and Ireland Cancer Center in Cleveland, Ohio) were randomized to receive music therapy given by trained music therapists or standard care. Outcome was assessed at baseline and every 3 days after randomization using the Profile of Mood States.


RESULTS
Of 69 patients registered in the study, follow-up data were available for 62 (90%). During their inpatient stay, patients in the music therapy group scored 28% lower on the combined Anxiety/Depression scale (P = 0.065) and 37% lower (P = 0.01) on the total mood disturbance score compared with controls.


CONCLUSIONS
Music therapy is a noninvasive and inexpensive intervention that appears to reduce mood disturbance in patients undergoing HDT/ASCT.
Cassileth
Barrie R
BR
Integrative Medicine Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. Cassileth@mskcc.org
Vickers
Andrew J
AJ
Magill
Lucanne A
LA
D000686:Amyloidosis / Q000473:pathology / Q000523:psychology / Q000628:therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000628:therapy*; D018572:Disease-Free Survival; D004305:Dose-Response Relationship, Drug; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006689:Hodgkin Disease / Q000473:pathology / Q000523:psychology / Q000628:therapy; D006760:Hospitalization; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000473:pathology / Q000523:psychology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009147:Music Therapy; D011795:Surveys and Questionnaires; D014182:Transplantation, Autologous; D016896:Treatment Outcome