[Effect of perftoran on microcirculation and target organs in early atherogenesis].
Effects of perfluoran, a plasma substitute with a gas-transport function, were studied at the stage of dyslipidogenic microangiopathy in rabbits. Changes in microcirculation, hemorheology, morphology of the liver, phospholipid composition of hepatocytic membranes were examined histologically, histochemically, electron microscopically and biochemically. Perfluoran produced a positive effect on microcirculation, phospholipid composition of hepatocytic membranes. Individual features of these parameters' dynamics were determined for animals.
Pozdniakov
O M
OM
Klimenko
E D
ED
Kobozeva
L P
LP
Michunskaia
A B
AB
Babakova
L L
LL
Leskova
G F
GF
Khugaeva
V N
VN
Moroz
V V
VV
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D005466:Fluorocarbons / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018056:Hemorheology; D007275:Injections, Intravenous; D008099:Liver / Q000098:blood supply / Q000648:ultrastructure*; D008102:Liver Circulation / Q000187:drug effects*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D011817:Rabbits
D000975:Antioxidants; D005466:Fluorocarbons; D010743:Phospholipids; C063334:perftoran