Anti-GAD antibody positive stiff-limb syndrome in multiple myeloma.
Although most cases of stiff-limb syndrome are unassociated with malignancy, occasional cases have been associated with breast and lung cancer. Only four reported patients have had cancer and stiff-limb syndrome associated with anti-GAD antibodies. We report the first case of stiff-limb syndrome in a patient with multiple myeloma undergoing treatment with thalidomide, and explore the potential link to the cancer and its treatment.
Schiff
David
D
Department of Neurological Surgery, University of Pittsburgh Medical Center, USA. ds4jd@virginia.edu
Dalmau
Josep
J
Myers
Delynne J
DJ
D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy; D016750:Stiff-Person Syndrome / Q000209:etiology* / Q000276:immunology; D013792:Thalidomide / Q000627:therapeutic use
D007074:Immunoglobulin G; D013792:Thalidomide; D005968:Glutamate Decarboxylase