Compositional biases and polyalanine runs in humans.
Human proteins containing polyalanine tracts tend to have runs of other amino acids and their open reading frames (ORFs) display a biased codon usage. Their alanine, glycine, proline, and histidine content strongly correlates with the GC content of the third codon base, suggesting that the compositional specificity of these proteins is dictated to a great extent by the evolution of their ORFs.
Cocquet
Julie
J
INSERM E0021 and U361, Reproduction et Physiopathologie Obstétricale, Hôpital Cochin, 75014 Paris, France.
De Baere
Elfride
E
Caburet
Sandrine
S
Veitia
Reiner A
RA
D003062:Codon; D006801:Humans; D016366:Open Reading Frames; D010455:Peptides / Q000235:genetics*
D003062:Codon; D010455:Peptides; C019529:polyalanine