title: [Study on effects of Erigeron breviscapus extract on anticoagulation].
abstract: OBJECTIVE
  To study the effect of Erigeron breviscapus extract on anticoagulation.
  
  
  METHODS
  Coagulation time (CT), prothrombin time (PT), platelet factor III (PF3) and euglobulin lysis time (ELT) have been used to evaluate the anticoagulation activities of Erigeron breviscapus extract.
  
  
  RESULTS
  Erigeron breviscapus extract significantly delayed CT and PT, inhibited the activity of PF3, and decreased ELT.
  
  
  CONCLUSIONS
  Erigeron breviscapus extract plays an role in anticoagulation by inhibiting PF3 and prothrombin V. It can also enhance the activity of fibrimolysis.
authors.affiliation: Huazhong University of Sciences and Technology, Wuhan 430074.
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiangliang
authors.initials: X
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Xiaoqiao
authors.initials: X
authors.lastname: Tang
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D005419:Flavonoids / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry; D010977:Platelet Factor 3 / Q000187:drug effects*; D011517:Prothrombin Time; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000925:Anticoagulants; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D010977:Platelet Factor 3