Ovarian choriocarcinoma arising from partial mole as evidenced by deoxyribonucleic acid microsatellite analysis.
BACKGROUND
Recent developments in genetic analysis allow determination of the origin of choriocarcinoma (ie, gestational or nongestational), which helps determine the strategy for clinical treatment of the disease.


METHODS
We present a case of ovarian choriocarcinoma forming a huge ovarian mass 40 days after the patient's last menstrual period. Deoxyribonucleic acid microsatellite analysis of the tumor revealed that it contained a single maternal and two paternal alleles at several independent loci, consistent with the tumor resulting from ovarian pregnancy of a partial hydatidiform mole.


CONCLUSIONS
This is the first description of an ovarian pregnancy of a partial hydatidiform mole-derived ovarian choriocarcinoma.
Namba
Akira
A
Department of Obstetrics and Gynecology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Nakagawa
Shunsuke
S
Nakamura
Naohito
N
Takazawa
Yutaka
Y
Kugu
Koji
K
Tsutsumi
Osamu
O
Taketani
Yuji
Y
D000328:Adult; D000483:Alleles; D002822:Choriocarcinoma / Q000150:complications* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D018895:Microsatellite Repeats; D010051:Ovarian Neoplasms / Q000150:complications* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D010298:Parity; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology / Q000601:surgery