[The vascular smooth muscle of great arteries: local control site of arterial buffering function?].
OBJECTIVE
To characterize the viscoelastic properties of the aorta and pulmonary arteries and the effects of vascular smooth muscle activation on arterial buffering function.


METHODS
Aortic and pulmonary artery pressure and diameter were measured in six anesthetized sheep under baseline conditions, and during arterial hypertension induced by mechanical vascular occlusion (passive), and i.v. phenylephrine (active). Arterial wall elasticity and viscosity were calculated, and buffering function was characterized: a) locally as the viscosity/elasticity ratio, and b) globally for each circuit, as the time-constant of ventricular relaxation.


RESULTS
Viscoelasticity was higher in the aorta than in the pulmonary artery (p < 0.05), however, parietal buffering function was similar in both. Global buffering function was highest in the systemic circuit (p < 0.05). During passive hypertension, elasticity was significantly increased with no change in viscosity; this led to a significant reduction in local buffering function, and in global buffering function in each circuit. During active hypertension, viscosity increased (p < 0.05), while local and global buffering functions returned to baseline values.


CONCLUSIONS
The viscosity/elasticity ratio was higher in the aorta than in the pulmonary artery, and arterial wall buffering function was similar in both vessels. Systemic global buffering function was higher than pulmonary circuit buffering function. Elasticity depends on intravascular pressure, whereas viscosity is a marker of the degree of smooth muscle activation. Smooth muscle activation may benefit the cardiovascular system by maintaining local and global buffering functions.
Bia
Daniel
D
Departamento de Fisiología. Facultad de Medicina. Universidad de la República. Montevideo. Uruguay. dbia@fmed.edu.uy
Armentano
Ricardo L
RL
Grignola
Juan C
JC
Craiem
Damián
D
Zócalo
Yanina A
YA
Ginés
Fernando F
FF
Levenson
Jaime
J
D000818:Animals; D001013:Aorta, Thoracic / Q000502:physiology*; D001696:Biomechanical Phenomena; D004548:Elasticity; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D011651:Pulmonary Artery / Q000502:physiology*; D012756:Sheep