A role for apoptosis induced by acute herpes simplex virus infection in mice.
Acute herpes simplex virus (HSV) infection causes apoptosis in the adrenal cortex and myenteric plexus of the gut, ovary, pituitary gland, and liver of mice. Apoptosis of infected cells is increased in immunosuppressed regions of the adrenal cortex and liver of macrophage-depleted mice. HSV carries the US3 gene which interferes with host cell apoptosis. When the livers of macrophage-depleted mice are infected with a US3-null virus, apoptosis occurs in the narrow areas of inflammatory cell infiltration, restricting viral replication and spread. Thus, these data suggest that apoptosis may function as a primitive immune response to HSV infection in mice.
Irie
Hiroshi
H
Department of Anatomy, Teikyo University School of Medicine, 2-11-1 kaga, Itabashi-Ku, Tokyo, 173-8605, Japan. h-irie@rb3.s0-net.ne.jp
Kiyoshi
Aita
A
Koyama
A Hajime
AH
D000311:Adrenal Glands / Q000276:immunology / Q000473:pathology; D000818:Animals; D017209:Apoptosis / Q000276:immunology / Q000502:physiology*; D001921:Brain / Q000473:pathology; D005260:Female; D005814:Genes, Viral; D006561:Herpes Simplex / Q000276:immunology / Q000473:pathology* / Q000821:virology; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000472:pathogenicity*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D009197:Myenteric Plexus / Q000473:pathology; D010053:Ovary / Q000473:pathology; D010902:Pituitary Gland / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000502:physiology; D014764:Viral Proteins
D014764:Viral Proteins; D017346:Protein Serine-Threonine Kinases; C095207:US3 protein, Human herpesvirus 1