A novel t(2;17) in transformation of essential thrombocythemia to acute myelocytic leukemia.
A transformation of essential thrombocythemia to acute myelocytic leukemia (AML), myelodysplastic syndrome, or agnogenic myelocytic metaplasia is a relatively rare event. It occurs in 1%-4.5% of all patients with either treated or untreated essential thrombocythemia. Cytogenetic changes in the transformation to AML are common. We report the case of a patient treated for essential thrombocythemia with hydroxyurea for 49 months. He developed AML with a t(2;17), which to our knowledge has not been described in the literature.
Lazarevic
Vladimir Lj
VLj
Institute of Hematology, Clinical Center of Serbia, Koste Todorovica 2 Street, Belgrade, Serbia, Yugoslavia. vladimir.lazarevic@vll.se
Tomin
Dragica
D
Jankovic
Gradimir M
GM
Antic
Darko
D
Dencic
Marija
M
Gotic
Mirjana
M
Boskovic
Darinka
D
D000368:Aged; D002886:Chromosomes, Human, Pair 17; D002889:Chromosomes, Human, Pair 2; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000235:genetics*; D008297:Male; D013920:Thrombocythemia, Essential / Q000150:complications* / Q000188:drug therapy; D014178:Translocation, Genetic