Protection against beta-amyloid peptide-induced memory impairment with long-term administration of extract of Angelica gigas or decursinol in mice.
We investigated the effect of long-term oral administration of ethanolic extract of Angelica gigas Nakai (Umbelliferae) (EAG) or decursinol, a coumarin isolated from A. gigas, on beta-amyloid peptide 1-42 (Abeta(1-42))-induced memory impairment in mice. Mice were allowed free access to drinking water (control) or water containing different concentrations of EAG. After 4 weeks, Abeta(1-42) (410 pmol) was administered via intracerebroventricular injection. Pretreatment of mice with EAG (0.1%) for 4 weeks significantly blocked the Abeta(1-42)-induced impairment in passive avoidance performance. Next, mice were fed with chow mixed with various doses of decursinol for 4 weeks before intracerebroventricular injection of Abeta(1-42) (410 pmol). Pretreatment of mice with decursinol (0.001%, 0.002%, and 0.004%) for 4 weeks significantly attenuated the Abeta(1-42)-induced impairment in passive avoidance performance. Decursinol (0.004%) also significantly blunted the Abeta(1-42)-induced decrease in alternation behavior (spatial working memory) in the Y-maze test without change in general locomotor activity. These findings suggest that EAG or decursinol may have preventive effect against memory impairment related with Abeta of Alzheimer's disease.
Yan
Ji-Jing
JJ
Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University, Chunchon, Kangwon-Do, 200-702, South Korea.
Kim
Do-Hoon
DH
Moon
Yoo-Sun
YS
Jung
Jun-Sub
JS
Ahn
Eun-Mi
EM
Baek
Nam-In
NI
Song
Dong-Keun
DK
D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D029969:Angelica / Q000737:chemistry*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001578:Benzopyrans / Q000627:therapeutic use*; D002087:Butyrates / Q000627:therapeutic use*; D000431:Ethanol; D007276:Injections, Intraventricular; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced* / Q000517:prevention & control*; D008570:Memory, Short-Term / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D010446:Peptide Fragments / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D008517:Phytotherapy; D012997:Solvents
D016229:Amyloid beta-Peptides; D001578:Benzopyrans; D002087:Butyrates; D010446:Peptide Fragments; D012997:Solvents; C075222:amyloid beta-protein (1-42); D000431:Ethanol; C101278:decursin