title: New strongylophorines from the Okinawan marine sponge Petrosia (Strongylophora) corticata.
abstract: New strongylophorines-22 (1), -23 (2), -24 (3), and -25 (4) were isolated from the Okinawan sponge Petrosia (Strongylophora) corticata along with other known strongylophorines. The structures of these strongylophorines were determined on the basis of spectroscopic analysis and chemical conversions. Assessment was also made of the cytotoxicity of strongylophorines-1, -2, -3, -4, -22 (1), -23 (2), and -24 (3) toward HeLa cells.
authors.affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Hoshino
authors.forename: Hidemichi
authors.initials: H
authors.lastname: Mitome
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Miyaoka
authors.forename: Akinori
authors.initials: A
authors.lastname: Shintani
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Yamada
authors.forename: Rob W M
authors.initials: RW
authors.lastname: van Soest
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007564:Japan; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes