title: Early experience with a novel plaque excision system for the treatment of complex coronary lesions.
abstract: The use of directional coronary atherectomy (DCA) in current practice has been limited. The SilverHawk System is a newly developed plaque excision device that aims to overcome the drawbacks of prior DCA platforms. The device was evaluated in a porcine coronary model and in a series of patients. Procedural variables along with outcomes were reviewed. Quantitative angiography (QCA) was performed and excised tissue fragments were weighed and examined histologically. In porcine cases, pretreatment MLD increased from 0.51 +/- 0.26 to 2.36 +/- 0.59 mm postdebulking and 19.9 +/- 7.6 mg of tissue was retrieved. In human cases, pretreatment MLD increased from 0.8 +/- 0.4 to 2.2 +/- 0.5 mm postdebulking and 15.2 +/- 7.8 mg of tissue was retrieved without complications. These data show that the SilverHawk System may offer significant utility in treating a wide variety of complex coronary lesions.
authors.affiliation: Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, California, USA.
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Ikeno
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Hinohara
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Robertson
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Rezaee
authors.forename: Paul G
authors.initials: PG
authors.lastname: Yock
authors.forename: Bernhard
authors.initials: B
authors.lastname: Reimers
authors.forename: Antonio
authors.initials: A
authors.lastname: Colombo
authors.forename: Eberhard
authors.initials: E
authors.lastname: Grube
authors.forename: John B
authors.initials: JB
authors.lastname: Simpson
mesh_terms: D000328:Adult; D000818:Animals; D017225:Atherectomy, Coronary / Q000379:methods*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D023421:Models, Animal; D013552:Swine; D016896:Treatment Outcome