Evaluation of surface and bulk characteristics of cellulose I powders in relation to compaction behavior and tablet properties.
The particle properties and solid-state characteristics of two celluloses, Avicel PH101 and cellulose obtained from the alga Cladophora sp., were evaluated and related to the compaction behavior and the properties of the tablets made from them. The surface area of the celluloses was measured at different levels of penetration capacity, ranging from external surface area of particles to molecular texture with Blaine permeametry, Kr-gasadsorption, and solid-state NMR. The important cellulose fibril surface area was best reflected by solid-state NMR, although for the Cladophora cellulose, Kr-gas adsorption also resulted in a surface area of the order of what has been suggested earlier on the basis of the cellulose fibril dimensions. The difference in fibril dimension and, thereby, the fibril surface area of the two celluloses was shown to be the primary factor in determining their properties and behavior. Properties such as the crystallinity and the tablet disintegration could be related to the fibril dimensions. The Cladophora cellulose resulted in rather strong compacts that still disintegrated rapidly. The irregular surface morphology of the particles and the fragmenting behavior of Cladophora probably contributed to the strength of the tablets.
Gustafsson
Christina
C
Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Lennholm
Helena
H
Iversen
Tommy
T
Nyström
Christer
C
D002482:Cellulose / Q000737:chemistry*; D000460:Chlorophyta / Q000737:chemistry; D003460:Crystallization; D005079:Excipients / Q000737:chemistry*; D008422:Materials Testing; D010316:Particle Size; D011208:Powders; D011312:Pressure; D013607:Tablets
D005079:Excipients; D011208:Powders; D013607:Tablets; D002482:Cellulose; C109691:microcrystalline cellulose