cis-[Pt(NH3)2(L)]2+/+ (L = Cl, H2O, NH3) binding to purines and CO: does pi-back-donation play a role?
The ability of cis-[Pt(NH(3))(2)(L)](2+/+), a molecular fragment of the anticancer drug cisplatin, to bind to purines and CO by pi-back-donation from Pt to the ligand was examined computationally. Optimized geometries and computed vibrational frequencies suggest that cis-[Pt(NH(3))(2)(L)](2+/+) (L = Cl, H(2)O, NH(3)) is a poor pi-donor and that pi-back-donation does not play an important role for Pt(II)-ligand interactions in general.
Baik
Mu-Hyun
MH
Department of Chemistry and School of Informatics, Indiana University, Bloomington, Indiana 47405, USA. mbaik@indiana.edu
Friesner
Richard A
RA
Lippard
Stephen J
SJ
D002248:Carbon Monoxide / Q000737:chemistry* / Q000378:metabolism; D002945:Cisplatin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry* / Q000378:metabolism; D011687:Purines / Q000737:chemistry* / Q000378:metabolism
D009944:Organoplatinum Compounds; D011687:Purines; D002248:Carbon Monoxide; D002945:Cisplatin