Kinetics of antibiotics release from ceramic implants.
Presented study describes kinetics of antibiotics release: cefazolin, gentamicin, netilmicin and vancomycin, from two types of ceramic implants: corundum and apatite cement prepared for osteosurgery. The experiments was based on our experimental model developed previously, in which the extraction of antibiotics from implants to polyurethane sponge was made for 3 days. The concentrations of antibiotics in the sponges were determined by spectrophotometric and biological methods. Among all ceramic materials tested, corundum implants with netilmicin and cement implants with gentamicin proved to be most efficacious regarding antibiotics release within 3 days of extraction to polyurethane sponge (yield of the release was 50% and 80% respectively). The lowest release was obtained in the case of cefazolin from cement disks (yield about 0.02%). The kinetics and effectiveness of antibiotics release from the ceramic implants tested depended on ceramic carrier and kind of the drug.
Lewandowski
Rafał
R
Department of Microbiology and Epidemiology, Military Institute of Hygiene and Epidemiology, Warsaw.
Grzybowski
Jacek
J
Karaś
Joanna
J
Jaegerman
Zbigniew
Z
Polesiński
Zbigniew
Z
D000537:Aluminum Oxide; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001031:Apatites; D002437:Cefazolin / Q000493:pharmacokinetics; D002516:Ceramics; D004343:Drug Implants; D005839:Gentamicins / Q000493:pharmacokinetics; D009428:Netilmicin / Q000493:pharmacokinetics; D011140:Polyurethanes; D013053:Spectrophotometry; D015503:Surgical Sponges; D014640:Vancomycin / Q000493:pharmacokinetics
D000900:Anti-Bacterial Agents; D001031:Apatites; D004343:Drug Implants; D005839:Gentamicins; D011140:Polyurethanes; D009428:Netilmicin; D014640:Vancomycin; D002437:Cefazolin; D000537:Aluminum Oxide