title: Bioconversion of compactin into pravastatin by Streptomyces sp.
abstract: Streptomyces sp. Y-110, isolated from soil, modified compactin to pravastatin, a therapeutic agent for hypercholesterolemia. In a batch culture, the highest production of pravastatin was 340 mg l(-1) from 750 mg compactin l(-1) in 24 h. By intermittent feeding of compactin into the culture medium, both the compactin concentration and its conversion increased to 2000 mg l(-1) and 1000 mg pravastatin l(-1), respectively, with the conversion rate of 10 mg l(-1) h(-1). Continuous feeding of compactin increased production of pravastatin to 15 mg l(-1) h(-1).
authors.affiliation: Biotechnology Laboratory, Youngjin Pharmaceutical Co. Ltd., Pyungtaek-Si 451-860, Korea.
authors.forename: Joo-Woong
authors.initials: JW
authors.lastname: Park
authors.forename: Joo-Kyung
authors.initials: JK
authors.lastname: Lee
authors.forename: Tae-Jong
authors.initials: TJ
authors.lastname: Kwon
authors.forename: Dong-Hee
authors.initials: DH
authors.lastname: Yi
authors.forename: Young-Jun
authors.initials: YJ
authors.lastname: Kim
authors.forename: Seong-Hoon
authors.initials: SH
authors.lastname: Moon
authors.forename: Hyun-Hyo
authors.initials: HH
authors.lastname: Suh
authors.forename: Sang-Mo
authors.initials: SM
authors.lastname: Kang
authors.forename: Yong-Il
authors.initials: YI
authors.lastname: Park
mesh_terms: D019149:Bioreactors / Q000382:microbiology*; D001711:Biotransformation; D018929:Cell Culture Techniques / Q000379:methods*; D002455:Cell Division / Q000502:physiology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008148:Lovastatin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D017035:Pravastatin / Q000096:biosynthesis*; D013302:Streptomyces / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism*
chemical_list: C012258:mevastatin; D003577:Cytochrome P-450 Enzyme System; D008148:Lovastatin; D017035:Pravastatin