Rapid tumor death model for evaluation of new therapeutic agents for adult T-cell leukemia.
Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasm. The health of ATL patients rapidly deteriorates resulting in death; however, the induction of death in a small animal model due to tumor has not yet been reported. SCID mice, 5 weeks old, younger than those previously used, which were inoculated with ATL cells, eliminated NK cell activity and showed rapid tumor formation resulting in death. Age is the crucial factor influencing tumor formation and death in the SCID mice model for cancer.
Ohsugi
Takeo
T
Division of Microbiology and Genetics, Center for Animal Resources and Development, Institute of Resource Development and Analysis, Kumamoto University, Kumamoto, Japan. ohsugi@gpo.kumamoto-u.ac.jp
Yamaguchi
Kazunari
K
Kumasaka
Toshio
T
Ishida
Takaomi
T
Horie
Ryouichi
R
Watanabe
Toshiki
T
Sakio
Noboru
N
Fujimoto
Toshio
T
Sakamoto
Noriyuki
N
Urano
Toru
T
D000367:Age Factors; D000818:Animals; D001609:Beta-Globulins / Q000032:analysis / Q000235:genetics; D002472:Cell Transformation, Viral; D004273:DNA, Neoplasm / Q000032:analysis; D016356:Gene Products, tax / Q000032:analysis / Q000235:genetics; D015490:HTLV-I Infections; D015368:Human T-lymphotropic virus 1 / Q000235:genetics* / Q000276:immunology; D016867:Immunocompromised Host; D007694:Killer Cells, Natural / Q000276:immunology; D015458:Leukemia, T-Cell / Q000276:immunology / Q000401:mortality / Q000821:virology; D008297:Male; D051379:Mice; D016513:Mice, SCID; D016133:Polymerase Chain Reaction; D015996:Survival Rate; D023041:Xenograft Model Antitumor Assays
D001609:Beta-Globulins; D004273:DNA, Neoplasm; D016356:Gene Products, tax