title: Effect of statins on the progression of bioprosthetic aortic valve degeneration.
abstract: To date, there is no proved medical therapy able to significantly reduce the degenerative process of biologic prosthetic aortic valves. It has recently been suggested that statins may reduce the progression of native aortic valve stenosis. We examined the effect of statin treatment on bioprosthetic aortic valve degeneration and found a beneficial effect of statins in slowing bioprosthetic degeneration.
authors.affiliation: Unità Operativa di Cardiologia, A.R.C., Azienda Ospedaliera S. Maria degli Angeli, Pordenone, Italy. cardiologia@aopn.fvg.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Antonini-Canterin
authors.forename: Alfredo
authors.initials: A
authors.lastname: Zuppiroli
authors.forename: Bogdan A
authors.initials: BA
authors.lastname: Popescu
authors.forename: Gianluca
authors.initials: G
authors.lastname: Granata
authors.forename: Eugenio
authors.initials: E
authors.lastname: Cervesato
authors.forename: Rita
authors.initials: R
authors.lastname: Piazza
authors.forename: Daniela
authors.initials: D
authors.lastname: Pavan
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Nicolosi
mesh_terms: D000368:Aged; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000601:surgery; D001022:Aortic Valve Insufficiency / Q000209:etiology / Q000517:prevention & control*; D001024:Aortic Valve Stenosis / Q000150:complications / Q000517:prevention & control*; D000069059:Atorvastatin; D001705:Bioprosthesis; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000150:complications; D005260:Female; D006350:Heart Valve Prosthesis; D006538:Heptanoic Acids / Q000627:therapeutic use; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000150:complications; D008297:Male; D017035:Pravastatin / Q000627:therapeutic use; D011475:Prosthesis Failure; D011758:Pyrroles / Q000627:therapeutic use; D012189:Retrospective Studies; D019821:Simvastatin / Q000627:therapeutic use; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D000069059:Atorvastatin; D019821:Simvastatin; D017035:Pravastatin