The value of routine follow-up in patients treated for carcinoma of the vulva.
BACKGROUND
Vulvar carcinoma patients traditionally are offered follow-up after their primary treatment because earlier diagnosis of recurrent disease is believed to improve chances for curative treatment. The objective of the current study was to determine the value of a strict routine follow-up protocol for the detection of recurrences in a large series of patients who were treated for carcinoma of the vulva.


METHODS
Clinicopathologic data for patients with primary squamous cell carcinoma of the vulva who were treated between January 1990 and July 2000 were prospectively stored in a database. After treatment, patients visited the outpatient clinic at the study institution at gradually increasing intervals. When a recurrence was diagnosed, it was indicated whether the recurrence was local, occurred in the skin bridge, occurred in the inguinal region, or was distant, and this information was registered. Moreover, it was noted whether the diagnosis was made at a routinely scheduled or at an interval follow-up meeting and whether symptoms as noted by the patient herself led to the diagnosis.


RESULTS
Data from 238 patients with International Federation of Gynecology and Obstetrics (FIGO) Stage I-IV vulvar carcinoma were analyzed with a mean follow-up of 63 months (median, 58 months; range, 6-149 months). Sixty-five of 238 patients (27%) developed recurrent disease; 49 were local recurrences, 2 recurrences were found in the skin bridge, 6 were found in the inguinal region, and 8 were distant recurrences. Forty-two of these 65 recurrences (65%) were detected at a routinely scheduled follow-up meeting, at which time 21 of the 42 patients with recurrent disease (50%) reported symptoms or signs. Local recurrences diagnosed at a routinely scheduled follow-up meeting were found to have a smaller greater dimension (mean, 2.1 cm and median, 1.6 cm; range, 0.3-8.0 cm) compared with recurrences detected at an interval meeting (mean, 3.1 cm and median, 3.0 cm; range, 0.4-7.0 cm) (P = 0.04).


CONCLUSIONS
The data from the current study indicated that routinely scheduled follow-up meetings with patients with carcinoma of the vulva result in the detection of smaller recurrences in a substantial proportion of patients compared with self-reported recurrences, without a measurable effect on morbidity or mortality.
Oonk
Maaike H M
MH
Department of Gynecologic Oncology, University Hospital Groningen, Groningen, The Netherlands.
de Hullu
Joanne A
JA
Hollema
Harry
H
Mourits
Marian J E
MJ
Pras
Elisabeth
E
Wymenga
Anke N M
AN
van der Zee
Ate G J
AG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000628:therapy; D003266:Continuity of Patient Care; D003955:Diagnostic Tests, Routine; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000628:therapy; D011379:Prognosis; D011446:Prospective Studies; D015996:Survival Rate; D014846:Vulvar Neoplasms / Q000175:diagnosis* / Q000628:therapy