[Correlation between the expression of collgen IV, VEGF and vasculogenic mimicry].
OBJECTIVE
To study the relationship between collgen (Col) IV, VEGF secreted by the tumor cells and vasculogenic mimicry (VM).


METHODS
158 bi-phase differential malignant tumor specimens were alloted and made into tissue microarray. These tissue microarray sections were stained with CD31, periodic acid-Schiff (PAS) and Col IV. Subsequently, distributive trait of Col IV and the difference of VEGF expression were analyzed.


RESULTS
The basement membrane of VM was PAS and Col IV positive. The expression of VEGF in bi-phase differential malignant tumor with VM was less than that in those without VM. The difference of VEGF expression in malignant melanoma and alveolar rhabdomyosarcoma was significant (P < 0.05).


CONCLUSIONS
Collgen IV and periodic acid-Schiff positive material take part in constructing the basement membrane of vasculogenic mimicry. The difference of the VEGF expression proves that vasculogenic mimicry can sustain the tumor blood supply.
Hao
Xi-shan
XS
Oncology Institute of Tianjin Medical University, Tianjin 300060, China.
Sun
Bao-cun
BC
Zhang
Shi-wu
SW
Zhao
Xiu-lan
XL
D024141:Collagen Type IV / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D009369:Neoplasms / Q000098:blood supply* / Q000737:chemistry / Q000473:pathology; D010503:Periodic Acid-Schiff Reaction; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis*
D024141:Collagen Type IV; D042461:Vascular Endothelial Growth Factor A