Antibody-mediated remyelination operates through mechanism independent of immunomodulation.
A set of antibodies capable of binding glial cells promotes remyelination in models of multiple sclerosis (MS). Within this set, the mouse antibody, SCH94.03, was immunomodulatory implying that immune system mobilization might be integral to remyelination. We evaluated whether the human remyelination-promoting antibody rHIgM22 influences acquired immunity. The antibody did not bind to immune cells, or influence humoral immune responses, antigen presentation, T cell proliferation or cytokine production. Treatment with rHIgM22 had no effect on demyelination or virus infection in two disease models. These results demonstrate that the remyelination-promoting activity of antibody rHIgM22 is not dependent on immunomodulation.
Ciric
Bogoljub
B
Department of Immunology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
Van Keulen
Virginia
V
Paz Soldan
Mateo
M
Rodriguez
Moses
M
Pease
Larry R
LR
D000276:Adjuvants, Immunologic / Q000502:physiology* / Q000627:therapeutic use; D000818:Animals; D000906:Antibodies / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000378:metabolism / Q000627:therapeutic use; D003711:Demyelinating Diseases / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000502:physiology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D013116:Spinal Cord / Q000187:drug effects / Q000276:immunology / Q000378:metabolism
D000276:Adjuvants, Immunologic; D000906:Antibodies; D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; C101676:SCH94.03 monoclonal antibody