title: The use of cytokines, fusion proteins and antibodies to treat cutaneous T-cell lymphoma.
abstract: It has long been known that certain immune augmenting therapeutics, particularly interferon alpha, can exert profound salutary effects on the clinical progress of patients with cutaneous T-cell lymphoma. Emerging evidence that the host immune response may play an important role in the control of this disorder has led to the clinical application of other cytokines including interleukin-12 and interferon gamma. In this review, the authors will summarize current knowledge regarding the use of cytokines, fusion proteins and antibodies for the treatment of cutaneous T-cell lymphoma.
authors.affiliation: Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. arook@mail.med.upenn.edu
authors.forename: Alain H
authors.initials: AH
authors.lastname: Rook
authors.forename: Karen S
authors.initials: KS
authors.lastname: McGinnis
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Richardson
authors.forename: Jeanne B
authors.initials: JB
authors.lastname: Budgin
authors.forename: Maria
authors.initials: M
authors.lastname: Wysocka
authors.forename: Bernice M
authors.initials: BM
authors.lastname: Benoit
authors.forename: Jacqueline M J
authors.initials: JM
authors.lastname: Hopkins
authors.forename: Carmela C
authors.initials: CC
authors.lastname: Vittorio
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D016207:Cytokines / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007372:Interferons / Q000627:therapeutic use*; D007378:Interleukins / Q000627:therapeutic use*; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D016207:Cytokines; D007378:Interleukins; D007372:Interferons