Discorhabdins S, T, and U, new cytotoxic pyrroloiminoquinones from a deep-water Caribbean sponge of the genus Batzella.
Discorhabdins S, T, and U (1-3), three new discorhabdin analogues, have been isolated from a deep-water marine sponge of the genus Batzella. These discorhabdin analogues showed in vitro cytotoxicity against PANC-1, P-388, and A-549 cell lines. The isolation and structure elucidation of discorhabdins S, T, and U are described.
Gunasekera
Sarath P
SP
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, Florida 34946, USA. sgunaseker@hboi.edu
Zuleta
Ignacio A
IA
Longley
Ross E
RE
Wright
Amy E
AE
Pomponi
Shirley A
SA
D000818:Animals; D001444:Bahamas; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007941:Leukemia P388; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D011758:Pyrroles; D011809:Quinones; D013141:Spiro Compounds; C482818:discorhabdin S; C482819:discorhabdin T; C482820:discorhabdin U