Effects of local administration of growth hormone in peri-implant bone: an experimental study with implants in rabbit tibiae.
OBJECTIVE
The objective of this study was to evaluate the qualitative and quantitative differences that could appear in newly formed peri-implant bone around Screw-Vent implants placed in rabbit tibiae when treated with local administration of growth hormone (GH).


METHODS
Eight New Zealand rabbits were randomly divided into 2 groups: the experimental group, which received 4 IU of GH in the form of lyophilized powder added to the ostectomy site before implant placement, and the control group, which did not receive GH before implant placement. Animals were sacrificed 2 weeks later, and histologic sections were obtained for histomorphometry and observation under light microscopy.


RESULTS
The sections in the GH-treated group presented enhanced growth of new trabeculae from the periosteal tissue, and the bone-to-implant contact in the experimental group was significantly greater (P < .05).


CONCLUSIONS
Local administration of GH stimulated a more dramatic effect than that seen previously with systemic GH administration, prompting growth from both the periosteum and endosteum.


CONCLUSIONS
Local administration of GH at the time of implant placement could enhance peri-implant bone reaction.
Tresguerres
Isabel F
IF
Department of Oral Medicine and Buccofacial Surgery, School of Dentistry, Complutense University, Madrid, Spain. f3f@eresmas.com
Blanco
Luis
L
Clemente
Celia
C
Tresguerres
Jesús A F
JA
D000287:Administration, Topical; D000818:Animals; D015921:Dental Implants; D013006:Growth Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D007091:Image Processing, Computer-Assisted; D016348:Osseointegration / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects; D010027:Osteotomy; D010521:Periosteum / Q000187:drug effects / Q000473:pathology; D011817:Rabbits; D011897:Random Allocation; D013977:Tibia / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D013997:Time Factors
D015921:Dental Implants; D013006:Growth Hormone