title: An update on new anticoagulants.
abstract: A variety of new anticoagulants for the prevention and treatment of venous and arterial thromboembolism are under development. Designed to overcome the limitations of heparin and vitamin K antagonists, these new agents are at various stages of clinical testing. This paper reviews venous and arterial thrombogenesis, discusses the regulation of coagulation, identifies the molecular targets for new anticoagulants, describes new anticoagulants in more advanced stages of clinical testing, and provides perspective on how these agents will impact on practice.
authors.affiliation: McMaster University and Henderson Research Centre, Hamilton, Ontario, Canada L8V 1C3.
authors.forename: Lori-Ann
authors.initials: LA
authors.lastname: Linkins
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Weitz
mesh_terms: D000925:Anticoagulants / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D013923:Thromboembolism / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants