title: Antileishmanial activity of aqueous onion extract in vitro.
abstract: Onion has had an important dietary and medicinal role for centuries. In this study the antileishmanial effect of aqueous onion extract (AOE) was investigated. Five leishmanial strains in the promastigote stage were studied in vitro. Seventy-two hour inoculation of AOE gave an IC100 and average IC50 values of 1.25 mg/ml and 0.376 mg/ml, respectively, against all leishmanial strains tested.
authors.affiliation: The Aga Khan University, Karachi, Pakistan. danishsaleheen@hotmail.com
authors.forename: Danish
authors.initials: D
authors.lastname: Saleheen
authors.forename: S Atif
authors.initials: SA
authors.lastname: Ali
authors.forename: M Masoom
authors.initials: MM
authors.lastname: Yasinzai
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D020128:Inhibitory Concentration 50; D007891:Leishmania / Q000145:classification / Q000187:drug effects*; D007896:Leishmaniasis / Q000188:drug therapy; D019697:Onions; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000981:Antiprotozoal Agents; D010936:Plant Extracts