title: Tuberculous radiculomyelitis: review and presentation of five patients.
abstract: BACKGROUND
  The southeast region of Iran is an endemic area for tuberculosis. Tuberculous radiculomyelitis (TBRM) was considered a rare form of parenchymal neurotuberculosis.
  
  
  OBJECTIVE
  To analyze the clinical, laboratory and electrophysiological data of patients with TBRM. We report five patients and review the literature.
  
  
  METHODS
  We searched Medline since 1966 and reviewed all cases of TBRM, excluding those with Pott's disease. We then evaluated the clinical and electrophysiological data of our patients.
  
  
  RESULTS
  Five patients (two men), with a mean age of 25 years, were assessed. The mean duration of symptoms before diagnosis was 4.5 weeks. Three patients had clinical manifestation of tuberculous meningitis (TBM). Diagnosis was based on sputum smear and culture, cerebrospinal fluid (CSF) culture and polymerase chain reaction (PCR) gene amplification of Mycobacterium tuberculosis. Paraparesis or paraplegia, sphincter incontinence and Babinski sign were the main clinical features. CSF analysis was compatible with chronic meningitis. Electromyography showed radiculopathy in all patients and peripheral nerve disease secondary to axonal damage in only three, while myelography showed adhesive arachnoiditis in three.
  
  
  CONCLUSIONS
  Despite the rarity of TBRM, clinical features were well described. To prevent neurological sequelae, early diagnosis and treatment is mandatory. Electrophysiological study may predict the prognosis.
authors.affiliation: Neurology Department, Zahedan University of Medical Sciences, Zahedan, Iran. amoghtaderi@lycos.com
authors.forename: A
authors.initials: A
authors.lastname: Moghtaderi
authors.forename: R
authors.initials: R
authors.lastname: Alavi Naini
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D004269:DNA, Bacterial / Q000032:analysis; D003906:Developing Countries; D004576:Electromyography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007492:Iran; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D009187:Myelitis / Q000382:microbiology* / Q000628:therapy; D016133:Polymerase Chain Reaction / Q000379:methods; D011843:Radiculopathy / Q000188:drug therapy / Q000382:microbiology*; D018570:Risk Assessment; D012494:Sampling Studies; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014390:Tuberculosis, Meningeal / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D004269:DNA, Bacterial