Incidence of aspirin nonresponsiveness using the Ultegra Rapid Platelet Function Assay-ASA.
We report the incidence of aspirin nonresponsiveness in a prospective, multicenter registry (n=422 patients) to be 23% using the Ultegra Rapid Platelet Function Assay-ASA, and determined a history of coronary artery disease to be associated with twice the odds of being an aspirin nonresponder (odds ratio 2.01, 95% confidence interval 1.189 to 3.411, p=0.009). Further prospective studies are needed to correlate aspirin nonresponsiveness to adverse clinical events.
Wang
John C
JC
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. jwang@partners.org
Aucoin-Barry
Denise
D
Manuelian
Deborah
D
Monbouquette
Rachele
R
Reisman
Mark
M
Gray
William
W
Block
Peter C
PC
Block
Elizabeth H
EH
Ladenheim
Marc
M
Simon
Daniel I
DI
D001241:Aspirin / Q000627:therapeutic use*; D003324:Coronary Artery Disease / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D004351:Drug Resistance; D005260:Female; D006400:Hematocrit; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D010976:Platelet Count; D010979:Platelet Function Tests / Q000379:methods; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012042:Registries
D010975:Platelet Aggregation Inhibitors; D001241:Aspirin