title: Giant-cell tumors of bone and progesterone receptors.
abstract: Estrogen receptors, progesterone receptors, and cathepsin D were determined in 10 patients with giant-cell bone tumor. Progesterone receptors were expressed in 5 of 10 patients tested, whereas low levels of estrogen receptors were found in 1 patient. Cathepsin D levels were elevated in 5 of 5 samples studied. High values of progesterone receptors correlated with low tumor grade. Cathepsin D levels correlated negatively with tumor grade but positively with local tumor expansion. Giant-cell bone tumor expressing progesterone receptors may manifest benign behavior. Cathepsin D may be involved in tumor expansion, possibly through its effect on bone resorption.
authors.affiliation: Department of Orthopedics, Metaxa Hospital, Athens, Greece.
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Demertzis
authors.forename: Fani
authors.initials: F
authors.lastname: Kotsiandri
authors.forename: Ioulia
authors.initials: I
authors.lastname: Giotis
authors.forename: Nikiphoros
authors.initials: N
authors.lastname: Apostolikas
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000378:metabolism* / Q000601:surgery; D002402:Cathepsin D / Q000378:metabolism*; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000378:metabolism* / Q000601:surgery; D006801:Humans; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000378:metabolism* / Q000601:surgery; D011256:Pregnancy Outcome; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D002402:Cathepsin D