TM or not TM: transmembrane protein prediction with low false positive rate using DAS-TMfilter.
Web-based servers implementing the DAS-TMfilter algorithm have been launched at three mirror sites and their usage is described. The underlying computer program is an upgraded and modified version of the DAS-prediction method. The new server is (approximately 1 among 100 unrelated queries) while the high efficiency of the original algorithm locating TM segments in queries is preserved (sensitivity of approximately 95% among documented proteins with helical TM regions).


BACKGROUND
The server operates at three mirror sites: http://mendel.imp.univie.ac.at/sat/DAS/DAS.html, http://wooster.bip.bham.ac.uk/DAS.html and http://www.enzim.hu/DAS/DAS.html. The program is available on request.
Cserzo
Miklos
M
Agricultural Biotechnology Center, Szent-Gyorgyi A. 4, Gödöllö, H-2100 Hungary.
Eisenhaber
Frank
F
Eisenhaber
Birgit
B
Simon
Istvan
I
D000465:Algorithms; D000595:Amino Acid Sequence; D030562:Databases, Protein; D005189:False Positive Reactions; D008565:Membrane Proteins / Q000737:chemistry* / Q000145:classification*; D008969:Molecular Sequence Data; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D017386:Sequence Homology, Amino Acid; D012984:Software
D008565:Membrane Proteins