title: [Correlation between chronic obstructive bronchial disease and colonic anastomosis dehiscence in the elderly].
abstract: BACKGROUND
  Anastomotic leakage remains a major complication after large bowel surgery. Chronic obstructive pulmonary disease is frequent disease in the elderly.
  
  
  OBJECTIVE
  The authors want to analyze the correlation between systemic tissue hypoxia, resulting from chronic obstructive pulmonary disease and anastomotic leakage in large bowel surgery in a group of patients over 65 years.
  
  
  METHODS
  In the period 1979-2001 at our surgical Department, 590 patients underwent colorectal surgery; 211 elderly patients (> 65 years) with large bowel anastomosis were selected. In 29/211 (13.7%) chronic obstructive pulmonary disease was diagnosed. The group of patients affected by chronic obstructive pulmonary disease was defined as group A; the other, as group B. The incidence of anastomotic leakage in patients with and without chronic obstructive pulmonary disease was evaluated.
  
  
  RESULTS
  The overall incidence of anastomotic leakage was 5.6% (12/211); a difference in the incidence of anastomotic leakage was found in the group A vs. B: 7/29 (24.1 %) in the group A were affected by dehiscence vs. 5/182 (2.7%) of group B. This difference was statistically significant (p = 0.001).
  
  
  CONCLUSIONS
  Chronic obstructive pulmonary disease can be a factor increasing the risk of anastomotic leakage. The elderly patient is often affected by chronic obstructive pulmonary disease and consequently show an higher risk of colonic anastomotic failure than younger patients.
authors.affiliation: Sezione di Chirurgia Generale, Vascolare ed Oncologia Clinica Dipartimento per le Applicazioni in Chirurgia delle Tecnologie, Bari, Italy. mario.testini@tin.it
authors.forename: M
authors.initials: M
authors.lastname: Testini
authors.forename: S
authors.initials: S
authors.lastname: Miniello
authors.forename: G
authors.initials: G
authors.lastname: Piccinni
authors.forename: B
authors.initials: B
authors.lastname: Di Venere
authors.forename: G
authors.initials: G
authors.lastname: Lissidini
authors.forename: E
authors.initials: E
authors.lastname: Esposito
authors.forename: G M
authors.initials: GM
authors.lastname: Bonomo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical; D003108:Colonic Diseases / Q000150:complications / Q000601:surgery; D015179:Colorectal Neoplasms / Q000150:complications / Q000601:surgery; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000209:etiology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications*; D012189:Retrospective Studies; D012306:Risk; D013529:Surgical Wound Dehiscence / Q000453:epidemiology / Q000209:etiology*