Predictors of remission in juvenile-onset recurrent respiratory papillomatosis.
OBJECTIVE
To determine factors associated with remission of juvenile-onset recurrent respiratory papillomatosis (JORRP).


METHODS
Longitudinal study.


METHODS
Twenty-two tertiary care centers located across the United States.


METHODS
The study included 165 patients diagnosed as having JORRP between January 1, 1997, and December 31, 2000. Kaplan-Meier curves and Cox proportional hazards models were used to determine associations between predictors and remission.


METHODS
Surgical excision and drug therapy.


METHODS
Remission of JORRP, defined as no surgical procedures for at least 1 year, as associated with age at diagnosis, drug therapy in the first year after diagnosis, number of surgical procedures in the first year after diagnosis, and number of anatomical sites of disease at diagnosis. Demographic factors (sex and race) and Medicaid status were also evaluated.


RESULTS
Older age at diagnosis was positively associated with remission of JORRP (hazards ratio for every increase of 1 year in age, 1.13; 95% confidence interval, 1.03-1.23).


CONCLUSIONS
Younger children were found to have persistent disease and often underwent an increased number of surgical procedures in the first year after diagnosis of JORRP. Sex and race were not important factors in determining remission.
Ruparelia
Snehal
S
Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA.
Unger
Elizabeth R
ER
Nisenbaum
Rosane
R
Derkay
Craig S
CS
Reeves
William C
WC
D017677:Age Distribution; D000367:Age Factors; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008484:Medicaid; D015999:Multivariate Analysis; D010212:Papilloma / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models; D012008:Recurrence; D012042:Registries; D012074:Remission Induction / Q000379:methods; D012086:Reoperation / Q000706:statistics & numerical data; D012142:Respiratory Tract Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D016019:Survival Analysis; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology