Effect of parenteral fluoroquinolone administration on persistence of vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract.
We examined the effect of subcutaneous fluoroquinolone antibiotic administration on persistence and density of vancomycin-resistant Enterococcus faecium stool colonization in mice. Levofloxacin and ciprofloxacin did not promote colonization in comparison to saline controls, whereas moxifloxacin and gatifloxacin promoted persistent overgrowth in a dose-dependent fashion.
Donskey
Curtis J
CJ
Research Service. Medical Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA. curtis123@yahoo.com
Helfand
Marion S
MS
Pultz
Nicole J
NJ
Rice
Louis B
LB
D000595:Amino Acid Sequence; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001483:Base Sequence; D015169:Colony Count, Microbial; D017931:DNA Primers; D004064:Digestive System / Q000382:microbiology*; D016984:Enterococcus faecium / Q000187:drug effects*; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000494:pharmacology*; D007263:Infusions, Parenteral; D051379:Mice; D008969:Molecular Sequence Data; D010802:Phylogeny; D020713:Vancomycin Resistance; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism
D000890:Anti-Infective Agents; D017931:DNA Primers; D024841:Fluoroquinolones; D001618:beta-Lactamases