The bovine (Bos taurus) CD11a-encoding cDNA: molecular cloning, characterisation and comparison with the human and murine glycoproteins.
The bovine cDNA encoding CD11a, a cell-surface glycoprotein involved in multiple leukocyte functions, was sequenced and compared with the human and murine sequences. Despite some focal differences, it shares all the main characteristics of its known mammalian homologs. Along with the bovine CD18-encoding cDNA, which is available for a long time, the sequence data provided here will allow the successful expression of bovine CD11a, thus giving the first opportunity to express the Bos taurus beta(2)-integrin CD11a/CD18 (LFA-1, alpha(L)beta(2)) in vitro as a tool to examine the specificities of inflammation in the bovine species.
Fett
T
T
Faculty of Veterinary Medicine, Department of Pathology, University of Liège, FMV Sart Tilman B43, B-4000 Liège, Belgium.
Zecchinon
L
L
Baise
E
E
Desmecht
D
D
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D040881:CD11a Antigen / Q000235:genetics*; D002417:Cattle / Q000235:genetics*; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry / Q000235:genetics* / Q000302:isolation & purification; D006023:Glycoproteins / Q000235:genetics; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid
D040881:CD11a Antigen; D018076:DNA, Complementary; D006023:Glycoproteins