The use of gene-manipulated mice in the validation of receptor binding radiotracer.
Eckelman
William C
WC
PET Department, Warren G. Magnuson Clinical Center, Bethesda, MD 20892, USA. Eckelman@nih.gov
D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D010641:Phenotype; D011485:Protein Binding; D011865:Radioisotope Dilution Technique; D011868:Radioisotopes / Q000493:pharmacokinetics*; D011869:Radioligand Assay / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D011955:Receptors, Drug / Q000378:metabolism; D015203:Reproducibility of Results; D013329:Structure-Activity Relationship; D014055:Tomography, Emission-Computed / Q000379:methods
D011868:Radioisotopes; D019275:Radiopharmaceuticals; D011956:Receptors, Cell Surface; D011955:Receptors, Drug