[Effects of monotherapy with an alpha1-adrenoblocker doxazosin and its combination with beta1-adrenoblocker atenolol on hemodynamics, reversible myocardial ischemia in postmyocardial infarction patients with arterial hypertension].
Effects of doxasozine and atenolol on hemodynamics and myocardial ischemia were studied in 20 males (mean age 52.5 +/- 5.3 years) who had survived macrofocal myocardial infarction associated with arterial hypertension stage I-II. The treatment efficacy was assessed clinically, by functional and radionuclide tests. A new long-acting alpha 1-adrenoblocker doxasozine was given in a mean dose 4-8 mg/day. A course of this treatment lowered systolic arterial pressure by 8.3% and diastolic one by 8.1%. As all the patients developed sinus tachycardia on day 5-10 of doxasozine treatment, the patients received additionally beta 1-adrenoblocker atenolol (12.5-25 mg/day) which adequately controlled heart rate. The combined therapy reduced frequency and severity of angina by 34.7%, 24-h need in nitroglycerine by 37.9%, exercise tolerance--by 18.4% as well as improved myocardial perfusion. Patients with concomitant benign prostatic hyperplasia showed attenuation of disuric disorders. Side effects (vertigo, anxiety) occurred in 3 cases (15%), but were not severe enough to demand the treatment discontinuation.
Tepliakov
A T
AT
Gavrilova
N V
NV
Garganeeva
A A
AA
D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage* / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000494:pharmacology; D000787:Angina Pectoris / Q000188:drug therapy; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001262:Atenolol / Q000008:administration & dosage* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D003627:Data Interpretation, Statistical; D017292:Doxazosin / Q000008:administration & dosage* / Q000494:pharmacology; D004359:Drug Therapy, Combination; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D001262:Atenolol; D017292:Doxazosin