title: A propensity score-matched cohort study of the effect of statins, mainly fluvastatin, on the occurrence of acute myocardial infarction.
abstract: This investigation quantified the effect of statins on acute myocardial infarction (AMI) in an observational setting where fluvastatin represented most of the statin use. The study applied propensity scores to match statin initiators to statin noninitiators and followed them for the occurrence of AMI. Serum low-density lipoprotein levels were reduced by statin therapy, and there were fewer incidents of AMI in statin initiators than in noninitiators.
authors.affiliation: Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. jseeger@epidemiology.com
authors.forename: John D
authors.initials: JD
authors.lastname: Seeger
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Walker
authors.forename: Paige L
authors.initials: PL
authors.lastname: Williams
authors.forename: Gordon M
authors.initials: GM
authors.lastname: Saperia
authors.forename: Frank M
authors.initials: FM
authors.lastname: Sacks
mesh_terms: D008078:Cholesterol, LDL / Q000097:blood*; D015331:Cohort Studies; D005229:Fatty Acids, Monounsaturated / Q000627:therapeutic use*; D005260:Female; D000077340:Fluvastatin; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000188:drug therapy*; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000517:prevention & control*; D011336:Probability; D016016:Proportional Hazards Models; D016896:Treatment Outcome
chemical_list: D008078:Cholesterol, LDL; D005229:Fatty Acids, Monounsaturated; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D000077340:Fluvastatin