The enhancement effect of gold nanoparticles as a surface modifier on DNA sensor sensitivity.
The enhancement of a single strain DNA probe linked to the sensor surface is of crucial importance in DNA molecule recognition. By means of nanogold modification of the sensor surface in addition to the nanogold amplifier, DNA detection sensitivity higher than 10(-16)mol/L was obtained in a Quartz Crystal microbalance (QCM) system, much higher than the ordinary QCM sensor without surface modification by nanogold.
Liu
Tao
T
Key Laboratory of Colloid and Interface Science, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, PR China.
Tang
Ji'an
J
Jiang
Long
L
D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000032:analysis*; D015342:DNA Probes / Q000737:chemistry; D017979:Gold Colloid / Q000737:chemistry*; D008854:Microscopy, Electron; D036103:Nanotechnology / Q000379:methods; D009693:Nucleic Acid Hybridization / Q000379:methods; D011791:Quartz / Q000737:chemistry; D012680:Sensitivity and Specificity; D013499:Surface Properties
D015342:DNA Probes; D017979:Gold Colloid; D011791:Quartz; D004247:DNA