title: Influence of demographics and inhalation injury on burn mortality in children.
abstract: BACKGROUND
  Pulmonary failure has emerged as one of the leading causes of mortality in burned children due, in part, to the success in reducing the incidence of sepsis, early surgery and fluid resuscitation, and new advances in nutritional support. To evaluate the effect of pulmonary injury, age, gender, race, and burn size on mortality, the records of 3179 burned children admitted to our burn center from 1985 to 2001 were reviewed. In this population, 1246 were admitted within 14 days of injury with burns greater than 20% of their total body surface area (TBSA).
  
  
  METHODS
  Lethal burn areas (LAs) for a thermal injury only or burn plus inhalation injury were estimated from best fit probit curve within 95% confidence limits. Data analysis was by chi(2)-test, t-test, or Fisher's exact test where appropriate.
  
  
  RESULTS
  The lethal burn area for a 10% mortality rate with and without concomitant inhalation injury was a 50 and 73% TBSA burn, respectively. Children up to the age of 3 with >/=20% TBSA burns had a higher rate of mortality (9.9%) compared to those 3-12 years of age (4.9%) and 13-18 years of age (4.2%). Children with 21-80% TBSA burns showed a significant difference in mortality (P<0.05) between those with burn plus inhalation injury (13.9%) and burn only (2.9%), while those with 81-100% TBSA burns showed no significant difference between burn only and burn plus inhalation injury.
  
  
  CONCLUSIONS
  Inhalation injury remains one of the primary contributors to burn mortality. Children under the age of 3 years, however, are at a higher risk both with and without inhalation injury.
authors.affiliation: Department of Surgery, Shriners Hospitals for Children, The University of Texas Medical Branch, 815 Market Street, Galveston, TX 77550, USA. rbarrow@utmb.edu
authors.forename: Robert E
authors.initials: RE
authors.lastname: Barrow
authors.forename: Marcus
authors.initials: M
authors.lastname: Spies
authors.forename: Laura N
authors.initials: LN
authors.lastname: Barrow
authors.forename: David N
authors.initials: DN
authors.lastname: Herndon
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002056:Burns / Q000208:ethnology / Q000401:mortality* / Q000473:pathology; D002059:Burns, Inhalation / Q000208:ethnology / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012307:Risk Factors; D012737:Sex Factors; D016019:Survival Analysis; D013781:Texas / Q000453:epidemiology