[The association between interleukin-1 receptor antagonist genotype and chronic periodontitis of Uighur patients].
OBJECTIVE
To investigate interleukin-1 receptor antagonist (IL-1ra) genotype and its association with the susceptibility of chronic periodontitis in Uighur patients of Xinjiang.


METHODS
Genomic DNA was obtained from buccal swabs of 41 subjects with severe chronic periodontitis (CP), 43 subjects with moderate CP, 49 subjects with mild CP and 92 ethnically matched healthy control individuals. Genotypes of IL-1RN intron 2 VNTR was analyzed by SSP-PCR method. Then compared the differences in distribution of each genotype.


RESULTS
A significant over-representation of IL-1RN intron 2 VNTR allele 2 was found in severe chronic periodontitis group.


CONCLUSIONS
IL-1RN intron 2 VNTR allele 2 may be a risk indicator for the susceptibility of severe chronic periodontitis in Uighur patients of Xinjiang.
Zhong
Liang-jun
LJ
Department of Stomatology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
Zhang
Yun-hui
YH
Zhang
Jin-cai
JC
Feng
Jin-hong
JH
Yang
Ai-ling
AL
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D010518:Periodontitis / Q000235:genetics*; D012795:Sialoglycoproteins / Q000235:genetics*
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D012795:Sialoglycoproteins