title: Recurrent primary fibrosarcoma of the brain treated with the GliaSite brachytherapy system: case report.
abstract: BACKGROUND
  Primary brain sarcomas are rarely curable with surgery and standard radiation therapy. They typically recur locally within 6 months of treatment. This case report describes a novel treatment approach for primary or recurrent brain sarcomas with intracavitary brachytherapy.
  
  
  METHODS
  This 34-year-old female presented with a large and rapidly recurrent primary fibrosarcoma in the right fronto-parietal brain only 1 month postinitial total resection. She was reoperated, again with an MRI-documented gross total resection, but at this second surgery a GliaSite RTS (a recently FDA-approved balloon catheter system for intracranial intracavitary brachytherapy) was inserted into the surgical cavity. Over four days a radiation dose of 152 Gy was delivered at the balloon surface dose and 50.0Gy was delivered at a depth of 7 mm from balloon surface. The patient received subsequent treatment with external beam radiation and chemotherapy. The patient tolerated her treatment well and has shown no evidence of tumor recurrence with a follow up of 18 months.
  
  
  CONCLUSIONS
  Boost intracavitary brachytherapy can play a critical role in preventing local recurrence and early death in patients with primary brain sarcomas.
authors.affiliation: Department of Radiation Oncology, Carolinas Medical Center, Charlotte, North Carolina 28204, USA.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Fraser
authors.forename: Steven A
authors.initials: SA
authors.lastname: Limentani
authors.forename: James D
authors.initials: JD
authors.lastname: Dollar
authors.forename: Anthony
authors.initials: A
authors.lastname: Asher
mesh_terms: D000328:Adult; D001918:Brachytherapy / Q000295:instrumentation / Q000379:methods*; D001932:Brain Neoplasms / Q000532:radiotherapy*; D005260:Female; D005354:Fibrosarcoma / Q000532:radiotherapy*; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*