title: Levels of fibroblast growth factor 2 in synovial fluids in human patients with internal derangement of the temporomandibular joint.
abstract: OBJECTIVE
  We sought to elucidate the levels of fibroblast growth factor 2 (FGF-2) in synovial fluid taken from internally deranged human temporomandibular joints (TMJs) and to discuss the role of FGF-2 in the pathogenesis of internal derangement.
  
  
  METHODS
  Through the use of a pumping procedure, diluted synovial fluid was collected from the upper joint compartment of 22 TMJs with evidence of internal derangement (21 patients) and 8 TMJs with no such evidence (5 control subjects). Two of the control subjects were patients who had habitual dislocation, and three were healthy volunteers. The level of FGF-2 in the synovial fluid was assessed by means of an enzyme-linked immunosorbent assay.
  
  
  RESULTS
  FGF-2 levels were at detectable levels in 15 of the 22 TMJs (68%) with internal derangement. The mean concentration of FGF-2 was 24 pg/mL. In the control group, FGF-2 levels were detectable in only 1 of 8 joints (13%), for a concentration of 3 pg/mL. The mean concentration of FGF-2 in the synovial fluid was significantly higher in the internal derangement group than in the control group (P =.02).
  
  
  CONCLUSIONS
  FGF-2 levels are elevated in the human synovial fluid of TMJs with internal derangement.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Kanazawa Medical University, Uchinada, Ishikawa Prefecture, Japan. jun-s@kanazawa-med.ac.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Sato
authors.forename: Natsuki
authors.initials: N
authors.lastname: Segami
authors.forename: Keiseki
authors.initials: K
authors.lastname: Kaneyama
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Konishi
authors.forename: Yoshino
authors.initials: Y
authors.lastname: Yoshitake
authors.forename: Katsuzo
authors.initials: K
authors.lastname: Nishikawa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001182:Arthroscopy; D001706:Biopsy; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000032:analysis* / Q000097:blood; D006801:Humans; D004204:Joint Dislocations / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D016059:Range of Motion, Articular / Q000502:physiology; D018709:Statistics, Nonparametric; D013582:Synovial Fluid / Q000737:chemistry*; D013583:Synovial Membrane / Q000473:pathology; D013704:Temporomandibular Joint / Q000378:metabolism; D019224:Temporomandibular Joint Disc / Q000473:pathology; D013705:Temporomandibular Joint Disorders / Q000378:metabolism*
chemical_list: D016222:Fibroblast Growth Factor 2