Effect of Aerva lanata on cisplatin and gentamicin models of acute renal failure.
The ethanol extract of the entire plant of Aerva lanata was studied for its nephroprotective activity in cisplatin- and gentamicin-induced acute renal injury in albino rats of either sex. In the curative regimen, the extract at dose levels of 75, 150 and 300 mg/kg showed dose-dependent reduction in the elevated blood urea and serum creatinine and normalized the histopathological changes in the curative regimen. In the gentamicin model the rats in the preventive regimen also showed good response to the ethanol extract at 300 mg/kg. The findings suggest that the ethanol extract of Aerva lanata possesses marked nephroprotective activity with minimal toxicity and could offer a promising role in the treatment of acute renal injury caused by nephrotoxins like cisplatin and gentamicin.
Shirwaikar
Annie
A
Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal 576119, Karnataka, India. annie.shirwaikar@cops.manipal.edu
Issac
Deepti
D
Malini
S
S
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D027703:Amaranthaceae; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002945:Cisplatin / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005839:Gentamicins / Q000009:adverse effects; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D023382:Toxicity Tests, Acute
D000975:Antioxidants; D005839:Gentamicins; D010936:Plant Extracts; D002945:Cisplatin