NKT cell frequency in Japanese type 1 diabetes.
A numerical and functional deficit of natural killer T (NKT) cells has been reported to be associated with the pathogenesis of Caucasian patients with type 1 diabetes. However, a conflicting finding of a higher frequency of NKT cells (Valpha24+ Vbeta11+ T cells) was observed in islet-associated Ab+ and Ab- Japanese "classic" type 1 diabetes. Here, we combined the data of NKT cell frequency in Ab+ and Ab- "classic" type 1 diabetic patients and then analyzed the relationship between NKT cell frequency and disease activity.
Oikawa
Yoichi
Y
Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan. y-oikawa@mvc.biglobe.ne.jp
Shimada
Akira
A
Yamada
Satoru
S
Motohashi
Yoshiko
Y
Nakagawa
Yoshinori
Y
Irie
Jun-Ichiro
J
Maruyama
Taro
T
Saruta
Takao
T
D000293:Adolescent; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007564:Japan; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D006442:Glycated Hemoglobin