title: A novel series of potent and selective IKK2 inhibitors.
abstract: A novel series of aminopyrimidine IKK2 inhibitors have been developed which show excellent in vitro inhibition of this enzyme and good selectivity over the IKK1 isoform. The relative potency and selectivity of these compounds has been rationalized using QSAR and structure-based modelling.
authors.affiliation: Celltech R&D Ltd, Granta Park, Great Abington, CB16GS, Cambridge, UK.
authors.forename: Alistair H
authors.initials: AH
authors.lastname: Bingham
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Davenport
authors.forename: Lewis
authors.initials: L
authors.lastname: Gowers
authors.forename: Roland L
authors.initials: RL
authors.lastname: Knight
authors.forename: Christopher
authors.initials: C
authors.lastname: Lowe
authors.forename: David A
authors.initials: DA
authors.lastname: Owen
authors.forename: David M
authors.initials: DM
authors.lastname: Parry
authors.forename: Will R
authors.initials: WR
authors.lastname: Pitt
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D051550:I-kappa B Kinase; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D011743:Pyrimidines; D017346:Protein Serine-Threonine Kinases; D051550:I-kappa B Kinase