title: Clinical comparison of Colgate Total Advanced Fresh vs a commercially available fluoride breath-freshening toothpaste in reducing breath odor overnight: a multiple-use study.
abstract: The objective of this randomized, crossover study was to compare the effectiveness of Colgate Total Advanced Fresh toothpaste to a commercially available breath-freshening dentifrice containing fluoride for its ability to reduce volatile sulfur compounds (VSC) responsible for breath odor overnight. The study followed a two-treatment, two-period crossover design. Subjects were given a test product, along with a soft-bristled toothbrush, and instructed to brush their teeth for 1 minute, twice daily (once in the morning and the evening) using the assigned dentifrice for 7 consecutive days. After their evening brushing on the seventh day, subjects reported to the testing facility without oral hygiene, eating, or drinking for the overnight evaluation. After a washout period, subjects repeated the same regimen, now using the other test product. The levels of breath VSC were evaluated instrumentally using a gas chromatograph equipped with a flame photometric detector.
authors.affiliation: Colgate-Palmolive Company Technology Center, Piscataway, New Jersey, USA.
authors.forename: Hollandra P
authors.initials: HP
authors.lastname: Niles
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Hunter
authors.forename: Joe
authors.initials: J
authors.lastname: Vazquez
authors.forename: Malcolm I
authors.initials: MI
authors.lastname: Williams
authors.forename: Diane
authors.initials: D
authors.lastname: Cummins
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001944:Breath Tests; D002849:Chromatography, Gas; D045424:Complex Mixtures; D018592:Cross-Over Studies; D003802:Dentifrices / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006209:Halitosis / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012824:Silicic Acid; D012822:Silicon Dioxide; D012969:Sodium Fluoride; D013457:Sulfur Compounds / Q000032:analysis; D014100:Toothpastes / Q000627:therapeutic use*; D014260:Triclosan
chemical_list: D045424:Complex Mixtures; D003802:Dentifrices; D013457:Sulfur Compounds; D014100:Toothpastes; C546060:hydrated silica gel-based toothpaste; D012824:Silicic Acid; D014260:Triclosan; D012822:Silicon Dioxide; D012969:Sodium Fluoride