title: Difference in gene expression profiles between human CD4+CD25+ and CD4+CD25- T cells.
abstract: We studied the gene expression profiles of human CD4+CD25+ and CD4+CD25- T cells by using cDNA microarrays. Our preliminary results indicate that there are likely significant differences in the regulation of apoptosis, cell cycle, cytokine receptor, cell-cell interaction, and stress pathway genes between these two subtypes of T cells.
authors.affiliation: Max McGee National Research Center for Juvenile Diabetes, Department of Pediatrics, Medical College and Children's Hospital of Wisconsin, Milwaukee, Wisconsin 53226, USA.
authors.forename: Nirupma
authors.initials: N
authors.lastname: Pati
authors.forename: Soumitra
authors.initials: S
authors.lastname: Ghosh
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Hessner
authors.forename: Huoy-Jii
authors.initials: HJ
authors.lastname: Khoo
authors.forename: Xujing
authors.initials: X
authors.lastname: Wang
mesh_terms: D015704:CD4 Antigens / Q000276:immunology*; D018076:DNA, Complementary; D020869:Gene Expression Profiling; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D015375:Receptors, Interleukin-2 / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015704:CD4 Antigens; D018076:DNA, Complementary; D015375:Receptors, Interleukin-2