title: [Genetic analysis of Yersinia pestis strains isolated in China].
abstract: OBJECTIVE
  The strains of Yersinia pestis isolated in different period and different natural foci in China were analyzed.
  
  
  METHODS
  Traditional and molecular biological methods were used. Rhamnose fermentation, rRNA gene copy number, nitrite reduction, and the glycerol fermentation were important characters for typing, and pulse field gel electrophoresis (PFGE) and random amplified polymorphic DNA (RAPD) profile could reflect the genetic distance between the strains.
  
  
  RESULTS
  The strains could be divided into 15 genetic types by those 6 characters with each of them covered an isolated geographical territories.
  
  
  CONCLUSIONS
  The characters of strains were described; the genetic relationship of different types, their evolution, and the forming and shift of plague natural foci were analyzed.
authors.affiliation: Institute for Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
authors.forename: Dong-zheng
authors.initials: DZ
authors.lastname: Yu
authors.forename: Rong
authors.initials: R
authors.lastname: Hai
authors.forename: Xing-qi
authors.initials: XQ
authors.lastname: Dong
authors.forename: Min
authors.initials: M
authors.lastname: Li
authors.forename: Lian-xu
authors.initials: LX
authors.lastname: Xia
authors.forename: Xian-ming
authors.initials: XM
authors.lastname: Shi
authors.forename: Jian-chun
authors.initials: JC
authors.lastname: Wei
authors.forename: Bai-zhong
authors.initials: BZ
authors.lastname: Cui
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Lian-zhi
authors.initials: LZ
authors.lastname: Sun
authors.forename: Zhi-kai
authors.initials: ZK
authors.lastname: Zhang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Hu
authors.forename: En-min
authors.initials: EM
authors.lastname: Zhang
mesh_terms: D002681:China; D030541:Databases, Genetic; D016521:Electrophoresis, Gel, Pulsed-Field; D040961:Genetic Drift; D005843:Geography; D009154:Mutation; D019105:Random Amplified Polymorphic DNA Technique; D015010:Yersinia pestis / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification