Association of intraoperative hypotension and pulmonary hypertension with adverse outcomes after orthotopic liver transplantation.
BACKGROUND
Various preoperative, surgical, and postoperative markers of impaired outcome after orthotopic liver transplantation have been reported, but the influence of intraoperative hemodynamic aberrations has not been thoroughly investigated.


METHODS
University Hospital.Study design Retrospective cohort analysis.


METHODS
The authors retrospectively reviewed computerized anesthesia records to determine associations between occurrences of abnormally low or high mean pulmonary artery pressure (MPAP), cardiac output, heart rate, systolic arterial pressure, diastolic arterial pressure, and mean arterial pressure (MAP) with negative surgical outcome. Negative surgical outcome was defined as poor early graft function, primary graft nonfunction, or death attributable to hemodynamic causes.


RESULTS
Of 789 patients, 142 (18.0%) had negative surgical outcome. Controlling for the influence of United Network for Organ Sharing (UNOS) status > 1, long operation time, cold donor organ ischemia time, and donor age, the only hemodynamic parameters that were independently associated with negative surgical outcome were MAP < 40 mmHg at least once during the procedure (odds ratio [OR] 2.39, p = 0.0016) and MPAP > 40 mmHg at least 3 times during the procedure (OR 2.2, p = 0.035). The occurrence of MAP < 40 mmHg was temporally associated with donor graft reperfusion. Hepatic artery thromboses were not associated with hemodynamic aberrations.


CONCLUSIONS
Hemodynamic events are independently associated with adverse outcomes after orthotopic liver transplantation.
Reich
David L
DL
Departmernt of Anesthesiology, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1010, New York, NY 10029-6574, USA. david.reich@msnyuhealth.org
Wood
Richard K
RK
Emre
Sukru
S
Bodian
Carol A
CA
Hossain
Sabera
S
Krol
Marina
M
Feierman
Dennis
D
D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D015331:Cohort Studies; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000503:physiopathology*; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology*; D007431:Intraoperative Complications / Q000209:etiology / Q000503:physiopathology*; D007432:Intraoperative Period; D016031:Liver Transplantation / Q000009:adverse effects* / Q000502:physiology; D015999:Multivariate Analysis; D016017:Odds Ratio; D012189:Retrospective Studies; D016896:Treatment Outcome