Expression of DC-SIGN in human foreskin may facilitate sexual transmission of HIV.
This study demonstrates that the human immunodeficiency virus (HIV) binding C-type lectin DC-SIGN is coexpressed with CD4 and CCR5 on dendritic cells/macrophages in human foreskin. It is hypothesised that DC-SIGN may contribute to the sexual transmission of HIV in the foreskin, by enabling infection of permissive cells in cis and/or in trans.
Soilleux
E J
EJ
Coleman
N
N
D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002944:Circumcision, Male; D015658:HIV Infections / Q000635:transmission*; D006801:Humans; D037181:Lectins, C-Type / Q000378:metabolism*; D008297:Male; D010413:Penis / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012867:Skin / Q000378:metabolism; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin