title: Individualised, micro CT-based finite element modelling as a tool for biomechanical analysis related to tissue engineering of bone.
abstract: Load-bearing tissues, like bone, can be replaced by engineered tissues or tissue constructs. For the success of this treatment, a profound understanding is needed of the mechanical properties of both the native bone tissue and the construct. Also, the interaction between mechanical loading and bone regeneration and adaptation should be well understood. This paper demonstrates that microfocus computer tomography (microCT) based finite element modelling (FEM) can have an important contribution to the field of functional bone engineering as a biomechanical analysis tool to quantify the stress and strain state in native bone tissue and in tissue constructs. Its value is illustrated by two cases: (1) in vivo microCT-based FEM for the analysis of peri-implant bone adaptation and (2) design of biomechanically optimised bone scaffolds. The first case involves a combined animal experimental and numerical study, in which the peri-implant bone adaptive response is monitored by means of in vivo microCT scanning. In the second case microCT-based finite element models were created of native trabecular bone and bone scaffolds and a mechanical analysis of both structures was performed. Procedures to optimise the mechanical properties of bone scaffolds, in relation to those of native trabecular bone are discussed.
authors.affiliation: Division of Biomechanics and Engineering Design (BMGO), Katholieke Universiteit Leuven (K.U.Leuven), Celestijnenlaan 200A, Leuven, Belgium. siegfried.jaecques@mech.kuleuven.ac.be
authors.forename: S V N
authors.initials: SV
authors.lastname: Jaecques
authors.forename: H
authors.initials: H
authors.lastname: Van Oosterwyck
authors.forename: L
authors.initials: L
authors.lastname: Muraru
authors.forename: T
authors.initials: T
authors.lastname: Van Cleynenbreugel
authors.forename: E
authors.initials: E
authors.lastname: De Smet
authors.forename: M
authors.initials: M
authors.lastname: Wevers
authors.forename: I
authors.initials: I
authors.lastname: Naert
authors.forename: J
authors.initials: J
authors.lastname: Vander Sloten
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena / Q000379:methods; D001858:Bone Nails; D018786:Bone Substitutes; D003198:Computer Simulation; D017076:Computer-Aided Design; D004548:Elasticity; D019544:Equipment Failure Analysis / Q000379:methods; D006168:Guinea Pigs; D008954:Models, Biological; D011474:Prosthesis Design / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D013977:Tibia / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000601:surgery; D023822:Tissue Engineering; D016474:Weight-Bearing
chemical_list: D018786:Bone Substitutes