Carbonic anhydrase inhibitors. inhibition of cytosolic isozymes I and II and transmembrane, cancer-associated isozyme IX with anions.
Except for sulfonamides, metal complexing anions represent the second class of inhibitors of the zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1). The first inhibition study of the transmembrane, tumor-associated isozyme CA IX with anions is reported here. Inhibition data of the cytosolic isozymes CA I and CA II with a large number of anionic species such as halides, pseudohalides, bicarbonate, nitrate, hydrosulfide, arsenate, etc., are also provided for comparison. Isozyme IX has an inhibition profile by anions different in some aspects from those of CA I and CA II, that may have interesting physiological consequences.
Vullo
Daniela
D
Università degli Studi di Firenze, Laboratorio di Chimica Bioinorganica, Rm. 188, Via della Lastruccia 3, 1-50019 Sesto Fiorentino, Firenze, Italy.
Franchi
Marco
M
Gallori
Enzo
E
Pastorek
Jaromir
J
Scozzafava
Andrea
A
Pastorekova
Silvia
S
Supuran
Claudiu T
CT
D000838:Anions / Q000494:pharmacology; D002245:Carbon Dioxide / Q000378:metabolism; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology*; D002256:Carbonic Anhydrases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000201:enzymology*
D000838:Anions; D002257:Carbonic Anhydrase Inhibitors; D007527:Isoenzymes; D002245:Carbon Dioxide; D002256:Carbonic Anhydrases