title: Cyclosporine enhances vasorelaxation in coronary but not pulmonary artery after 16-hour preservation with UW solution.
abstract: Cyclosporine (CsA), a calcineurin inhibitor, has been associated with endothelial dysfunction in transplant patients. Human and in vitro studies suggest that CsA produces endothelial dysfunction by impairing vascular endothelium-dependent relaxation. However, little is know about the CsA effects to modulate the vasorelaxation after prolonged graft preservation. In this study using a protocol designed to eliminate the influences of infusion pressure and shear stress, we evaluated the effect of CsA on vasorelaxation of coronary and pulmonary arteries after 16-hour University of Wisconsin (UW) solution preservation.
authors.affiliation: Division of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Tao Yuan Hsien, Kwei-Shan 333, Taiwan, ROC.
authors.forename: Y
authors.initials: Y
authors.lastname: Chu
authors.forename: Y C
authors.initials: YC
authors.lastname: Wu
authors.forename: Y C
authors.initials: YC
authors.lastname: Chou
authors.forename: H P
authors.initials: HP
authors.lastname: Liu
authors.forename: J J
authors.initials: JJ
authors.lastname: Chu
authors.forename: P J
authors.initials: PJ
authors.lastname: Lin
mesh_terms: D000241:Adenosine; D000493:Allopurinol; D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology*; D016572:Cyclosporine / Q000494:pharmacology*; D004285:Dogs; D005978:Glutathione; D007328:Insulin; D023421:Models, Animal; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions; D011651:Pulmonary Artery / Q000187:drug effects / Q000502:physiology*; D011887:Raffinose; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D014665:Vasodilator Agents; D000493:Allopurinol; D016572:Cyclosporine; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose