title: Clonal cytotoxic T cells in myeloma.
abstract: Multiple myeloma (MM) is a malignant disease characterized by accumulation of morphologically recognizable plasma cells producing immunoglobulin (Ig) in the bone marrow. The occurrence of clonal T cells in MM, as defined by the presence of rearrangements in the T-cell receptor (TCR)-beta chains detected on Southern blotting, is associated with an improved prognosis. This review aims to describe the various ways in which we have demonstrated the presence of such T cell clones, and to describe the phenotype of these cells. Finally, the specificities of these clinically important CD8+ T cell populations will be discussed in the context of immunotherapy.
authors.affiliation: Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia. d.sze@centenary.usyd.edu.au
authors.forename: Daniel M Y
authors.initials: DM
authors.lastname: Sze
authors.forename: Ross D
authors.initials: RD
authors.lastname: Brown
authors.forename: Edna
authors.initials: E
authors.lastname: Yuen
authors.forename: John
authors.initials: J
authors.lastname: Gibson
authors.forename: Joy
authors.initials: J
authors.lastname: Ho
authors.forename: Maria
authors.initials: M
authors.lastname: Raitakari
authors.forename: Antony
authors.initials: A
authors.lastname: Basten
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Joshua
authors.forename: Barbara
authors.initials: B
authors.lastname: Fazekas de St Groth
mesh_terms: D001853:Bone Marrow / Q000473:pathology; D002999:Clone Cells / Q000276:immunology / Q000473:pathology; D005544:Forecasting; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D010641:Phenotype; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000473:pathology
chemical_list: D011948:Receptors, Antigen, T-Cell