3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors.
The binding of a series pyridylbutynylamines 6 was examined at alpha4beta2 nACh receptors. Structural modifications, comparing 6 with pyridyl ethers 2, did not consistently result in parallel effects on receptor affinity, suggesting possible differences in their modes of binding. Furthermore, the binding of amine 6a seemed to be accounted for by the newer vector pharmacophore models.
Dogruer
Deniz
D
Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, VA 23298-0540, Richmond, USA.
Lee
Mase
M
Dukat
Malgorzata
M
Damaj
M Imad
MI
Martin
Billy R
BR
Glennon
Richard A
RA
D000818:Animals; D000440:Butanols; D002531:Cerebellum / Q000378:metabolism; D011485:Protein Binding / Q000502:physiology; D011725:Pyridines / Q000737:chemistry* / Q000378:metabolism*; D051381:Rats; D011978:Receptors, Nicotinic / Q000378:metabolism*
D000440:Butanols; D011725:Pyridines; D011978:Receptors, Nicotinic; C403531:nicotinic receptor alpha4beta2; C021965:3-butyn-1-ol