Preparation and evaluation of sulfur-containing metal chelators.
With a view to probe the structure and function of G-protein coupled receptors the synthesis of functionalized 8-mercaptoquinoline derivatives and 2-(2-pyridyl)thiophenol was achieved. A fluorescence-based method for determining the affinity of these metal chelators toward zinc ions was developed.
Clavier
Sylvain
S
Karolinska Institute, Center for Nutrition and Toxicology, Novum Research Park, SE-141 57 Huddinge, Sweden.
Rist
Oystein
O
Hansen
Stina
S
Gerlach
Lars-Ole
LO
Högberg
Thomas
T
Bergman
Jan
J