title: [Role of Chlamydia, mycoplasma and cytomegalovirus infection in the development of coronary artery disease].
abstract: OBJECTIVE
  To assess relationship between some infection factors and presence of coronary heart disease.
  
  
  METHODS
  Patients with myocardial infarction (n=56), unstable angina (n=50), stable angina (n=50) and age - matched controls (n=49).
  
  
  METHODS
  Levels of IgG, IgM, IgA antibodies to Chlamydia pneumonia, Chlamydia trachomatis, Chlamydia psittaci, IgG, IgM antibodies to Cytomegalovirus, and also of antibodies and antigen to Mycoplasma pneumoniae were measured in blood serum.
  
  
  RESULTS
  Compared with controls patients with coronary heart disease had higher frequency of seropositivity to Chlamydia pneumonia, Mycoplasma pneumonia and Cytomegalovirus (p< 0.05 ) and similar levels of seropositivity to Chlamydia trachomatis and Chlamydia psittaci. Infectious burden (quantity of antibodies per one patient) was significantly higher in patients with myocardial infarction, unstable and stable angina than in controls (1.58, 1.42, 1.41 and 0.95, respectively).
  
  
  CONCLUSIONS
  Our results confirm presence of association between infection and coronary heart disease.
authors.affiliation: Cardiology Research Complex; ul. Tretiya Cherepkovskaya 15a, 121552 Moscow, Russia.
authors.forename: A B
authors.initials: AB
authors.lastname: Basinkevich
authors.forename: R M
authors.initials: RM
authors.lastname: Shakhnovich
authors.forename: V R
authors.initials: VR
authors.lastname: Martynova
authors.forename: N I
authors.initials: NI
authors.lastname: Kolkova
authors.forename: I V
authors.initials: IV
authors.lastname: Rakovskaia
authors.forename: N V
authors.initials: NV
authors.lastname: Karazhas
authors.forename: L F
authors.initials: LF
authors.lastname: Evseeva
authors.forename: A B
authors.initials: AB
authors.lastname: Dobrovolskiĭ
authors.forename: A D
authors.initials: AD
authors.lastname: Deev
authors.forename: E A
authors.initials: EA
authors.lastname: Noeva
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Ruda
mesh_terms: D000328:Adult; D000368:Aged; D002690:Chlamydia Infections / Q000097:blood / Q000150:complications* / Q000382:microbiology; D003586:Cytomegalovirus Infections / Q000097:blood / Q000150:complications* / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009175:Mycoplasma Infections / Q000097:blood / Q000150:complications* / Q000382:microbiology; D017202:Myocardial Ischemia / Q000097:blood / Q000382:microbiology*