title: JASPAR: an open-access database for eukaryotic transcription factor binding profiles.
abstract: The analysis of regulatory regions in genome sequences is strongly based on the detection of potential transcription factor binding sites. The preferred models for representation of transcription factor binding specificity have been termed position-specific scoring matrices. JASPAR is an open-access database of annotated, high-quality, matrix-based transcription factor binding site profiles for multicellular eukaryotes. The profiles were derived exclusively from sets of nucleotide sequences experimentally demonstrated to bind transcription factors. The database is complemented by a web interface for browsing, searching and subset selection, an online sequence analysis utility and a suite of programming tools for genome-wide and comparative genomic analysis of regulatory regions. JASPAR is available at http://jaspar. cgb.ki.se.
authors.affiliation: Center for Genomics and Bioinformatics, Karolinska Institutet, Berzelius väg 35, S-17177 Stockholm, Sweden.
authors.forename: Albin
authors.initials: A
authors.lastname: Sandelin
authors.forename: Wynand
authors.initials: W
authors.lastname: Alkema
authors.forename: Pär
authors.initials: P
authors.lastname: Engström
authors.forename: Wyeth W
authors.initials: WW
authors.lastname: Wasserman
authors.forename: Boris
authors.initials: B
authors.lastname: Lenhard
mesh_terms: D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D019295:Computational Biology; D004247:DNA / Q000235:genetics / Q000378:metabolism; D030561:Databases, Nucleic Acid; D005057:Eukaryotic Cells / Q000378:metabolism; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D008969:Molecular Sequence Data; D020218:Response Elements / Q000235:genetics*; D012984:Software; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic; D014584:User-Computer Interface
chemical_list: D014157:Transcription Factors; D004247:DNA