title: [Studies of BMPR-IB and BMP15 as candidate genes for fecundity in little tailed han sheep].
abstract: BMPR-IB gene which controls the fecundity of Booroola Merino and BMP15 gene which affects the ovulation of Invedale and Hanna were studied as candidate genes on the fecundity of Little Tailed Han Sheep, and their mutations and genetic effects were analyzed. The results showed that there was a same mutation in BMPR-IB gene (A746G) of Little Tailed Han Sheep as that of Booroola Merino. The BB mutation genotype was superior in prolific Little Tailed Han Sheep, and the ewes with genotype BB had 0.97(P < 0.05) and 1.5(P < 0.01) lambs more than those with genotype + + in the first parity and later parities, respectively. It could be inferred that BMPR-IB gene was related with the major gene that controls the high prolificacy of Little Tailed Han Sheep. While there was not mutation of V31D or Q23Ter in BMP15 gene of Little Tailed Han Sheep, it showed that the fecundity mechanism of Little Tailed Han Sheep was different from that of Romney sheep. Then it was ruled out the possibility that the ovulation of Little Tailed Han Sheep was affected by the mutation of BMP15 gene.
authors.affiliation: College of Animal Science and Technology, Shandong Agricultural University, Taian 271018, China.
authors.forename: Shu-Fang
authors.initials: SF
authors.lastname: Liu
authors.forename: Yun-Liang
authors.initials: YL
authors.lastname: Jiang
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Du
mesh_terms: D000483:Alleles; D000818:Animals; D001483:Base Sequence; D052005:Bone Morphogenetic Protein Receptors, Type I; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004252:DNA Mutational Analysis; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005260:Female; D005298:Fertility / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D055429:Growth Differentiation Factor 9; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D009154:Mutation; D010060:Ovulation / Q000235:genetics; D011110:Polymorphism, Genetic; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D017978:Receptors, Growth Factor / Q000235:genetics*; D012756:Sheep / Q000235:genetics*; D013045:Species Specificity
chemical_list: D055429:Growth Differentiation Factor 9; D036341:Intercellular Signaling Peptides and Proteins; D017978:Receptors, Growth Factor; D004247:DNA; D017346:Protein Serine-Threonine Kinases; D052005:Bone Morphogenetic Protein Receptors, Type I; C056436:endodeoxyribonuclease SpeI; C025580:endodeoxyribonuclease XBAI; D015252:Deoxyribonucleases, Type II Site-Specific; C038308:GGWCC-specific type II deoxyribonucleases