[Urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion in women with pregnancy complicated with hypertension].
OBJECTIVE
Hypertensive disorders in pregnancy are one of the major mortality risk factors for mother and fetus. Although pathomechanisms of hypertension are extreme complex, the involvement of kidneys usually occurs. N-acetyl-beta-D-glucosaminidase (NAG) is a lysosomal enzyme which is located in renal tubular cells. Therefore an elevation of urinary NAG activity serves as a marker of tubular cell damage.


OBJECTIVE
Evaluation of renal tubular damage in pregnant women with different types of hypertension by determination of urinary NAG activity.


METHODS
The study comprised 84 pregnant women in third trimester, divided according to type of hypertension into 3 subgroups: pregnancy induced hypertension (n = 58), preeclampsia (n = 13) and chronic hypertension (n = 13). The control group comprised 36 healthy pregnant women. Urinary NAG activity was measured in the second morning urine samples by colorimetric method and the results were expressed as NAG/creatinine ratios (NAG/Cr).


RESULTS
The highest NAG/Cr ratios were found in women with preeclampsia (median-1.520 U/mmol) and in women with pregnancy induced hypertension (median-0.874 U/mmol) and both results differed significantly from those in controls (median-0.782 U/mmol). There was slight positive correlation between NAG/Cr ratios and systolic blood pressure (r = 0.225, p < 0.05).


CONCLUSIONS
Hypertension in pregnancy may lead to renal tubular damage, however clinical significance of this phenomenon requires further studies.
Semczuk-Sikora
Anna
A
Katedry i Kliniki Połoznictwa i Patologii Ciazy AM w Lublinie.
Sikora
Przemysław
P
Biaduń
Urszula
U
Semczuk
Marian
M
D000118:Acetylglucosaminidase / Q000652:urine*; D000328:Adult; D016022:Case-Control Studies; D003124:Colorimetry / Q000379:methods; D005260:Female; D006801:Humans; D006977:Hypertension, Renal / Q000150:complications / Q000201:enzymology* / Q000652:urine; D011225:Pre-Eclampsia / Q000201:enzymology* / Q000209:etiology / Q000652:urine; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000201:enzymology* / Q000652:urine*; D012016:Reference Values; D018709:Statistics, Nonparametric; D013997:Time Factors
D000118:Acetylglucosaminidase