[Neutrophilic and lymphocytic factors of an immune response in renal tuberculosis].
Fifty-eight patients with nephrotuberculosis at its peak were found to have a high functional activity of neutrophilic granulocytes, as determined by the lysosomal cation test, by the levels of myeloperoxidase and lactoferrin. The subpopulation of lymphocytes, concentrations of tumor necrosis factor-alpha (TNF-alpha), interleukin-2 (IL-2), as well as those of IL-2 in a combination with its soluble receptor (SR-2) in the serum and supernatant of cellular cultures stimulated by phytohemagglutitin and PPD were studied. The findings suggest that there is a close correlation between the high concentrations of IL-2 and PP-alpha and the decreased content of activated lymphocytes expressing receptors to IL-2 (CD25+). Clinical remission has been ascertained to be attended only by a partial normalization of immunological parameters with antituberculous therapy.
Iagafarova
R K
RK
Potapenko
E I
EI
Shenderova
R I
RI
Iakunova
O A
OA
Korolenok
O L
OL
Kusursuz
M O
MO
Sushkova
E A
EA
D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002478:Cells, Cultured; D004796:Clinical Enzyme Tests; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007376:Interleukin-2 / Q000097:blood; D007781:Lactoferrin / Q000097:blood; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology; D009195:Peroxidase / Q000097:blood; D013997:Time Factors; D014398:Tuberculosis, Renal / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D000995:Antitubercular Agents; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D009195:Peroxidase; D007781:Lactoferrin