title: [Two cases of pancreatic head polypeptide tumors, one with a central cavity which fistulized into the duodenum].
abstract: PP omas are rare, usually malignant tumours of the PP cells of the Langerhan's islets which secrete pancreatic polypeptide. The authors present two women operated for PP-omas of the pancreas. The first was 55 year-old woman in whom we did a cephalic duodenopancreatectomy (Whipple's procedure) for the tumor of the head of the pancreas with central cavity containing gas due to communication with the duodenum. Immunohistochemistry showed a PP oma with strong generalised immunoreactivity with antibodies against Chromogramin A, neuron specific enolasa and PP with more the 95% of tumor cells and coexpression of somatostatine in 35% and VIP in less then 5% of tumor cells. Following uneventful recovery the patient stayed symptom free so far and put 20 kilograms in weight. The second patient was 19 year-old girl with a multinodal tumor of almost the entire pancreas in whom a local excision of the nodal mass of the head of the pancreas had been carried out in the other hospital, three years ago and relaparotomy and tumor biopsy a month before admission to our institution. In her we did a total duodenopancreatectomy and standard lymphadenectomy for a multinodal mass occupying almost the entire pancreas. Immunohistochemistry showed a strong generalised immunoreactivity with antibodies against Chromographin A, Neuron specific enolasa and PP for more then 95% of tumors, cells. Glucagon was expressed in few focuses (in less then 1% of cells), somatostatin was expressed very rarely in single cells while the rest of tumor markers did not show a visible immunologic reactions in the majority of tumors, cells. Three years after surgery she died due to multiple liver secondaries.
authors.affiliation: Institute of Digestive Diseases, Clinical Centre of Serbia, Koste Todorovića 6, 11000 Beograd.
authors.forename: Radoje
authors.initials: R
authors.lastname: Colović
authors.forename: Nikica
authors.initials: N
authors.lastname: Grubor
authors.forename: Marjan
authors.initials: M
authors.lastname: Micev
authors.forename: Natasa
authors.initials: N
authors.lastname: Colović
authors.forename: Vera
authors.initials: V
authors.lastname: Todorivić
authors.forename: Milena
authors.initials: M
authors.lastname: Cosić-Micev
mesh_terms: D000328:Adult; D004378:Duodenal Diseases / Q000209:etiology* / Q000601:surgery; D005260:Female; D006801:Humans; D007412:Intestinal Fistula / Q000209:etiology* / Q000601:surgery; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D010191:Pancreatic Polypeptide / Q000378:metabolism*
chemical_list: D010191:Pancreatic Polypeptide