Influence of recipient and donor IL-1alpha, IL-4, and TNFalpha genotypes on the incidence of acute renal allograft rejection.
OBJECTIVE
To determine whether polymorphisms of the genes encoding donor or recipient interleukin 1alpha (IL-1alpha), tumour necrosis factor alpha (TNFalpha), or IL-4 have any impact on the incidence of acute rejection after renal transplantation.


METHODS
All donors and recipients were genotyped for three polymorphisms in the three cytokine genes: IL1A -889, TNFA -308, and IL4 -590.


RESULTS
Statistical analysis of the data obtained revealed no association between the cytokine gene polymorphisms tested and the incidence of post-transplant acute rejection. After stratification for human leucocyte antigen (HLA) matching, it was found that kidneys from donors positive for the TNFA-A allele had a significantly increased incidence of acute rejection in HLA-DR mismatched transplants.


CONCLUSIONS
This finding argues for prospective TNFA genotyping of renal donors, with avoidance of allocation of kidneys from donors positive for the TNFA-A allele to HLA-DR mismatched recipients.
Lee
H
H
Department of Transplantation Immunology, St James's University Hospital, Leeds, LS9 7TF, UK. helena.lee@cmmc.nhs.uk
Clark
B
B
Gooi
H C
HC
Stoves
J
J
Newstead
C G
CG
D000208:Acute Disease; D016207:Cytokines / Q000235:genetics*; D005838:Genotype; D006084:Graft Rejection / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics; D015847:Interleukin-4 / Q000235:genetics; D016030:Kidney Transplantation / Q000276:immunology*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length
D016207:Cytokines; D007375:Interleukin-1; D015847:Interleukin-4