Demethylation of 2,4-dimethoxyquinolines: the synthesis of atanine.
The synthesis of the quinoline alkaloid atanine 6, by selective demethylation of the 2,4-dimethoxyquinoline 11 is presented. An alternative demethylation utilising a thiolate anion leads to the regioisomeric 4-hydroxyquinoline 13.
Jones
Keith
K
Department of Chemistry, King's College London, Strand, London, UK WC2R 2LS. keith.jones@kingston.ac.uk
Roset
Xavier
X
Rossiter
Sharon
S
Whitfield
Philip
P
D008745:Methylation; D008956:Models, Chemical; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry
D011804:Quinolines; D015363:Quinolones; C094654:atanine