Determination of the herbicide isoproturon in cereal grains and pasta by LC with LC/MS confirmation.
A method was developed for the determination of the herbicide isoproturon in wheat, maize, oats and pasta, with a limit of determination of 0.05 mg kg(-1). Isoproturon was extracted from moistened samples using a mixture of acetone, hexane and dichloromethane. The resulting extract was cleaned-up by solid-phase extraction using aminopropyl-bonded silica cartridges and analysed by reversed-phase liquid chromatography with photodiode array detection. Confirmation was by electrospray liquid chromatography-mass spectrometry. Recoveries from seven samples of each of the four matrices spiked with isoproturon at 0.05 and 0.5 mg kg(-1) were in the range 88-104%. The method was used to monitor cereal grains and pasta as part of the UK food monitoring programme.
Winrow
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Central Science Laboratory, Sand Hutton, York YO41 1LZ, UK.
Hird
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Brown
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P
D018554:Avena / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002853:Chromatography, Liquid / Q000379:methods; D002523:Edible Grain / Q000737:chemistry*; D006540:Herbicides / Q000032:analysis*; D013058:Mass Spectrometry / Q000379:methods; D008782:Methylurea Compounds / Q000032:analysis*; D010671:Phenylurea Compounds; D015203:Reproducibility of Results; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D014908:Triticum / Q000737:chemistry; D003313:Zea mays / Q000737:chemistry
D006540:Herbicides; D008782:Methylurea Compounds; D010671:Phenylurea Compounds; C028904:isoproturon