title: Effect of digestive site acidity and compatibility on the species, lipopily and bioavailability of iron, manganese and zinc in Prunus persica Batsch and Carthamus tinctorus.
abstract: The effects of compatibility, that is combination of Prunus persica Batsch (L.) and Carthamus tinctorus (L.), and different acidity of digestive site on the species, lipopily and bioavailability of coordinated complex of iron, manganese, and zinc in medical decoction were studied. In view of octanol, a long-chain alkanol, resembled as the configuration of carbohydrate and adipose in human body, the octanol- and water-solubility were used to define the species of trace element in phytomedicine, to identify the lipopily and bioavailability of trace element, and octanol-water system was adopted to study the distribution of trace element in decoction of P. persica Batsch (L.) (A), C. tinctorus (L.) (B), and combination of medicine A and B (C) in stomach and intestine. The total concentration, water- and octanol-solubility concentration of iron, manganese, and zinc in medicinal material A, B and C or its decoction under gastric and intestinal acidity, were determined respectively by flame atomic absorption spectrometry, analyzed and compared. The compatibility of medicine A and B enhances the extract percent, octanol-solubility concentration, and stability of coordinated complex of iron, manganese, and zinc. Different acidity of digestive site and compatibility of medicines impact on the ligands of iron, manganese, and zinc, then greatly affect the species and its quantification, the lipopily and bioavailability of trace element. Such influence is quite different for different trace element. Such factors, especially the concentration of octanol-solubility trace element, could be the basis of the dosage to avoid trace element overload.
authors.affiliation: Zhangzhou Teachers College, 363000, PR, Zhangzhou, China.
authors.forename: Li
authors.initials: L
authors.lastname: Shun-xing
authors.forename: Deng
authors.initials: D
authors.lastname: Nan-sheng
authors.forename: Zheng
authors.initials: Z
authors.lastname: Feng-ying
mesh_terms: D001665:Binding Sites / Q000502:physiology; D001682:Biological Availability; D031187:Carthamus tinctorius; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification; D005744:Gastric Acid / Q000502:physiology*; D006801:Humans; D007422:Intestines / Q000737:chemistry / Q000502:physiology*; D007501:Iron / Q000302:isolation & purification* / Q000378:metabolism; D050356:Lipid Metabolism; D008345:Manganese / Q000302:isolation & purification* / Q000378:metabolism; D027861:Prunus; D013045:Species Specificity; D015032:Zinc / Q000302:isolation & purification* / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D008345:Manganese; D007501:Iron; D015032:Zinc