title: Effect of platelet-rich plasma on bone regeneration in autogenous bone graft.
abstract: In this study, we evaluated the effect of platelet-rich plasma (PRP) on bone regeneration in an autogenous bone graft in a canine model. The mandibular premolar teeth had been bilaterally extracted previously, and the ridges had been allowed to heal for 3 months. After this period, continuity resection was performed on both sides of the mandible. One defect (the PRP group) was reconstructed with the original particulate bone mixed with PRP. As a control, the contralateral defect (non-PRP group) was reconstructed with the original particulate bone alone. Biopsies after 6 weeks showed lower levels of bone formation in the PRP group than in the non-PRP group, and fluorescence microscopy revealed a delay in the remodelling of grafts loaded with PRP. These findings suggest that the addition of PRP does not appear to enhance new bone formation in autogenous bone grafts.
authors.affiliation: Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University (Brain Korea 21 Project for Medical Science), Kangwon-Do, South Korea. choibh@wongju.yonsei.ac.kr
authors.forename: B-H
authors.initials: BH
authors.lastname: Choi
authors.forename: C-J
authors.initials: CJ
authors.lastname: Im
authors.forename: J-Y
authors.initials: JY
authors.lastname: Huh
authors.forename: J-J
authors.initials: JJ
authors.lastname: Suh
authors.forename: S-H
authors.initials: SH
authors.lastname: Lee
mesh_terms: D000818:Animals; D001792:Blood Platelets; D001861:Bone Regeneration / Q000187:drug effects / Q000502:physiology*; D016025:Bone Transplantation / Q000379:methods / Q000502:physiology*; D004285:Dogs; D005782:Gels / Q000494:pharmacology; D008334:Mandible / Q000601:surgery*; D008856:Microscopy, Fluorescence; D019647:Oral Surgical Procedures; D010956:Plasmapheresis; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D019651:Plastic Surgery Procedures
chemical_list: D005782:Gels; D010982:Platelet-Derived Growth Factor