Animal models of spinal cord injury for evaluation of tissue engineering treatment strategies.
Tissue engineering approaches to spinal cord injury (SCI) treatment are attractive because they allow for manipulation of native regeneration processes involved in restoration of the integrity and function of damaged tissue. A clinically relevant spinal cord regeneration animal model requires that the model mimics specific pathologic processes that occur in human SCI. This manuscript discusses issues related to preclinical testing of tissue engineering spinal cord regeneration strategies from a number of perspectives. This discussion includes diverse causes, pathology and functional consequences of human SCI, general and species related considerations, technical and animal care considerations, and data analysis methods.
Talac
R
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Departments of Orthopaedic Surgery and Biomedical Engineering, Mayo Clinic and Mayo Medical School, Medical Sciences Building Room 3-69, 200 1st Street SW, Rochester, MN 55905, USA. yaszemski.michael@mayo.edu
Friedman
J A
JA
Moore
M J
MJ
Lu
L
L
Jabbari
E
E
Windebank
A J
AJ
Currier
B L
BL
Yaszemski
M J
MJ
D000818:Animals; D018929:Cell Culture Techniques / Q000295:instrumentation / Q000379:methods*; D004195:Disease Models, Animal; D006801:Humans; D015601:Injury Severity Score; D009416:Nerve Regeneration / Q000502:physiology*; D019736:Prostheses and Implants; D013045:Species Specificity; D013119:Spinal Cord Injuries / Q000503:physiopathology* / Q000601:surgery*; D023822:Tissue Engineering / Q000295:instrumentation / Q000379:methods*; D019737:Transplants; D016896:Treatment Outcome