ASD: the Alternative Splicing Database.
Alternative splicing is widespread in mammalian gene expression, and variant splice patterns are often specific to different stages of development, particular tissues or a disease state. There is a need to systematically collect data on alternatively spliced exons, introns and splice isoforms, and to annotate this data. The Alternative Splicing Database consortium has been addressing this need, and is committed to maintaining and developing a value-added database of alternative splice events, and of experimentally verified regulatory mechanisms that mediate splice variants. In this paper we present two of the products from this project: namely, a database of computationally delineated alternative splice events as seen in alignments of EST/cDNA sequences with genome sequences, and a database of alternatively spliced exons collected from literature. The reported splice events are from nine different organisms and are annotated for various biological features including expression states and cross-species conservation. The data are presented on our ASD web pages (http://www.ebi.ac.uk/asd).
Thanaraj
T A
TA
European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. thanaraj@ebi.ac.uk
Stamm
Stefan
S
Clark
Francis
F
Riethoven
Jean-Jack
JJ
Le Texier
Vincent
V
Muilu
Juha
J
D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D019295:Computational Biology; D030561:Databases, Nucleic Acid; D005091:Exons / Q000235:genetics; D006801:Humans; D016247:Information Storage and Retrieval; D007438:Introns / Q000235:genetics; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D020033:Protein Isoforms / Q000235:genetics; D022821:RNA Splice Sites / Q000235:genetics; D038621:Regulatory Sequences, Ribonucleic Acid; D012984:Software
D020033:Protein Isoforms; D022821:RNA Splice Sites; D038621:Regulatory Sequences, Ribonucleic Acid