title: Hypoxia and pulmonary acclimatisation at 4578 m altitude: the role of acetazolamide and dexamethasone.
abstract: OBJECTIVE
  To quantify the changes in ventilatory response and arterial blood gases in healthy male volunteers on acute ascent to 4578 meters altitude along with evaluating the role of acetazolamide and dexamethasone prophylaxis in acclimatisation.
  
  
  METHODS
  Forty four lowlander male subjects participated as two groups in the study. Twenty four lowlander healthy male adults (age mean +/- SE 27.8 +/- 1.24 years) comprised the non-acclimatised group. They were sub grouped in a double blind fashion into four. Each subgroup (n=6) received placebo (multivitamin) or acetazolamide (250 mg) or dexamethasone (4 mg) or combined regimen of the two drugs twice daily for 5 days commencing 24 hours before ascent. The volunteers reached the altitude of 4578 meters within a span of one day. The second group (acclimatised) comprised of age and height matched twenty volunteers who had arrived 4 and 8 weeks earlier at the same altitude. Arterial PO2, PCO2, SO2 and minute respiratory rate pH were measured. The pulmonary functions (FVC, %FEV1 PEF, FEF(25-75%) and MVV) were recorded by Compact Spirometer (Vitalograph). Pre and post ascent measurements were carried out in non-acclimatised group whereas one measurement of the same parameters were made in acclimatised group.
  
  
  RESULTS
  The study revealed a significant increase in respiratory rate min-1 after 24 hours of ascent along with reduction in PaO2 and SaO2. The gradual increase in PaO2 and SaO2 and reduction in PaCO2 was observed after 4 weeks at the same altitude. The reduction in FVC, %FEV1, PEF, FEF(25-75%) and MW were recorded in our subjects after 24 hours of acute ascent. Nevertheless, all pulmonary parameters in volunteers having 8 weeks of stay at 4578 m altitude, were found equivalent to the non-acclimatised group. The greater increase in minute respiratory rate, PaO2, SaO2 and pulmonary functions was found in volunteers taking acetazolamide.
  
  
  CONCLUSIONS
  It is concluded that hyperventilation and increase in lung volumes are the adaptive pulmonary responses which help in improving levels of PaO2 and SaO2. The acetazolamide-dexamethasone prophylaxis appears beneficial in promoting pulmonary acclimatisation during hypobaric hypoxia.
authors.affiliation: High Altitude Medical Research Cell, Army Medical College, Rawalpindi.
authors.forename: M M
authors.initials: MM
authors.lastname: Hussain
authors.forename: M
authors.initials: M
authors.lastname: Aslam
mesh_terms: D000064:Acclimatization / Q000187:drug effects / Q000502:physiology*; D000086:Acetazolamide / Q000627:therapeutic use*; D000328:Adult; D000531:Altitude; D000532:Altitude Sickness / Q000517:prevention & control; D000932:Antiemetics / Q000627:therapeutic use*; D016022:Case-Control Studies; D003907:Dexamethasone / Q000627:therapeutic use*; D006801:Humans; D000860:Hypoxia / Q000517:prevention & control*; D008168:Lung / Q000187:drug effects / Q000502:physiology*; D008297:Male; D012119:Respiration / Q000187:drug effects
chemical_list: D000932:Antiemetics; D003907:Dexamethasone; D000086:Acetazolamide