Formamidine ureas as tunable electrophiles.
Formamidine urea compounds exchange imine fragments with primary nitrogen nucleophiles, allowing the preparation of a variety of derivatives from a single precursor. The reactivities of these species are governed primarily by the electron-donating power of the substituents and are tunable over a range of >10(3) in first-order rates of hydrolysis.
Díaz
David D
DD
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd. La Jolla, CA 92037, USA.
Finn
M G
MG