Inhibition of CD1 expression in human dendritic cells during intracellular infection with Leishmania donovani.
Dendritic cells can initiate antimicrobial responses by CD1-mediated presentation of pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of abundant parasite glycolipids.
Amprey
Joseph L
JL
Weill Medical College of Cornell University, New York, New York, USA.
Späth
Gerald F
GF
Porcelli
Steven A
SA
D000818:Animals; D018949:Antigens, CD1 / Q000378:metabolism*; D002460:Cell Line; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000378:metabolism* / Q000469:parasitology*; D015536:Down-Regulation; D006801:Humans; D007893:Leishmania donovani / Q000472:pathogenicity*; D007898:Leishmaniasis, Visceral / Q000469:parasitology; D008213:Lymphocyte Activation; D013601:T-Lymphocytes
D018949:Antigens, CD1