title: A case of acute generalized exanthematous pustulosis (AGEP) possibly induced by iohexol.
abstract: Acute generalized exanthematous pustulosis (AGEP) is an uncommon disease manifested as an erythematous pustular eruption. It is usually caused by systemic medication. We describe a patient with acute generalized pustular eruption induced by iohexol. A 52-year-old woman developed fever and a generalized pustular eruption on the neck, trunk and extremities three days after taking iohexol. The culture from pustules was sterile. Other systemic and laboratory examinations were normal. A skin biopsy from a lesion on the trunk showed the features of a drug-induced pustular eruption as a subcorneal blister including neutrophils and eosinophils, mild spongiosis, and a sparse infiltrate at neutrophils and eosinophils in the papillary dermis. The patient had no history of psoriasis. The lesions resolved with systemic corticosteroid therapy within one week and did not relapse. According to our investigation, iohexol-induced AGEP has not been previously reported. We present an interesting case.
authors.affiliation: Atatürk University, School of Medicine, Department of Dermatology, Erzurum, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Atasoy
authors.forename: Teoman
authors.initials: T
authors.lastname: Erdem
authors.forename: Refik Ali
authors.initials: RA
authors.lastname: Sari
mesh_terms: D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001707:Biopsy, Needle; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007472:Iohexol / Q000009:adverse effects*; D008875:Middle Aged; D018570:Risk Assessment; D012720:Severity of Illness Index; D017444:Skin Diseases, Papulosquamous / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D007472:Iohexol