title: Glutamate and GABA concentrations in the cerebellum of novel ataxic mutant Pogo mice.
abstract: The Pogo mouse is an autosomal recessive ataxic mutant that arose spontaneously in the inbred KJR/MsKist strain derived originally from Korean wild mice. The ataxic phenotype is characterized by difficulty in maintaining posture and side to side stability, faulty coordination between limbs and trunk, and the consequent inability to walk straight. In the present study, the cerebellar concentrations of glutamate and GABA were analyzed, since glutamate is a most prevalent excitatory neurotransmitter whereas gamma-aminobutyric acid (GABA) is one of the most abundant inhibitory neurotransmitters, which may be the main neurotransmitters related with the ataxia and epilepsy. The concentration of glutamate of cerebellum decreased significantly in ataxic mutant Pogo mouse compared to those of control mouse. However, GABA concentration was not decrease. These results suggested that the decrease in glutamate concentration may contribute to ataxia in mutant Pogo mouse.
authors.affiliation: Department of Anatomy & Pathology, College of Medicine, Konyang Univiversity, Nonsan 320-711, Korea.
authors.forename: Ki-Hyung
authors.initials: KH
authors.lastname: Kim
authors.forename: Jeoung-Hee
authors.initials: JH
authors.lastname: Ha
authors.forename: Seung-Hyuk
authors.initials: SH
authors.lastname: Chung
authors.forename: Chul-Tae
authors.initials: CT
authors.lastname: Kim
authors.forename: Sun-Kyung
authors.initials: SK
authors.lastname: Kim
authors.forename: Byung-Hwa
authors.initials: BH
authors.lastname: Hyun
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Sawada
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Fukui
authors.forename: Il-Kwon
authors.initials: IK
authors.lastname: Park
authors.forename: Geun-jwa
authors.initials: GJ
authors.lastname: Lee
authors.forename: Bum-Kyeong
authors.initials: BK
authors.lastname: Kim
authors.forename: Nam-Seob
authors.initials: NS
authors.lastname: Lee
authors.forename: Young-Gil
authors.initials: YG
authors.lastname: Jeong
mesh_terms: D000818:Animals; D064026:Calbindins; D002531:Cerebellum / Q000378:metabolism* / Q000473:pathology; D020234:Gait Ataxia / Q000378:metabolism* / Q000473:pathology; D018698:Glutamic Acid / Q000378:metabolism*; D007150:Immunohistochemistry; D051379:Mice; D008817:Mice, Mutant Strains; D064030:S100 Calcium Binding Protein G / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D064026:Calbindins; D064030:S100 Calcium Binding Protein G; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid