title: Protection against beta-amyloid peptide-induced memory impairment with long-term administration of extract of Angelica gigas or decursinol in mice.
abstract: We investigated the effect of long-term oral administration of ethanolic extract of Angelica gigas Nakai (Umbelliferae) (EAG) or decursinol, a coumarin isolated from A. gigas, on beta-amyloid peptide 1-42 (Abeta(1-42))-induced memory impairment in mice. Mice were allowed free access to drinking water (control) or water containing different concentrations of EAG. After 4 weeks, Abeta(1-42) (410 pmol) was administered via intracerebroventricular injection. Pretreatment of mice with EAG (0.1%) for 4 weeks significantly blocked the Abeta(1-42)-induced impairment in passive avoidance performance. Next, mice were fed with chow mixed with various doses of decursinol for 4 weeks before intracerebroventricular injection of Abeta(1-42) (410 pmol). Pretreatment of mice with decursinol (0.001%, 0.002%, and 0.004%) for 4 weeks significantly attenuated the Abeta(1-42)-induced impairment in passive avoidance performance. Decursinol (0.004%) also significantly blunted the Abeta(1-42)-induced decrease in alternation behavior (spatial working memory) in the Y-maze test without change in general locomotor activity. These findings suggest that EAG or decursinol may have preventive effect against memory impairment related with Abeta of Alzheimer's disease.
authors.affiliation: Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University, Chunchon, Kangwon-Do, 200-702, South Korea.
authors.forename: Ji-Jing
authors.initials: JJ
authors.lastname: Yan
authors.forename: Do-Hoon
authors.initials: DH
authors.lastname: Kim
authors.forename: Yoo-Sun
authors.initials: YS
authors.lastname: Moon
authors.forename: Jun-Sub
authors.initials: JS
authors.lastname: Jung
authors.forename: Eun-Mi
authors.initials: EM
authors.lastname: Ahn
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.forename: Dong-Keun
authors.initials: DK
authors.lastname: Song
mesh_terms: D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D029969:Angelica / Q000737:chemistry*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001578:Benzopyrans / Q000627:therapeutic use*; D002087:Butyrates / Q000627:therapeutic use*; D000431:Ethanol; D007276:Injections, Intraventricular; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced* / Q000517:prevention & control*; D008570:Memory, Short-Term / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D010446:Peptide Fragments / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D008517:Phytotherapy; D012997:Solvents
chemical_list: D016229:Amyloid beta-Peptides; D001578:Benzopyrans; D002087:Butyrates; D010446:Peptide Fragments; D012997:Solvents; C075222:amyloid beta-protein (1-42); D000431:Ethanol; C101278:decursin