Lack of association of HLA class I genes and TNF alpha-308 polymorphism in toluene diisocyanate-induced asthma.
BACKGROUND
Toluene diisocyanate (TDI)-induced asthma is a common cause of occupational asthma and it affects 5-15% of the exposed population suggesting an underlying genetic susceptibility.


METHODS
To investigate the role of genetic factors in the development of TDI-induced asthma, we analyzed the distribution of human leukocyte antigen (HLA) class I genes and of tumor necrosis factor (TNF)-alpha A-308G polymorphism in 142 patients with TDI-induced asthma and in 50 asymptomatic exposed subjects.


RESULTS
Neither the distribution of HLA class I antigens nor the distribution of TNF-alpha A-308G polymorphism was different between patients with TDI-induced asthma and asymptomatic exposed subjects.


CONCLUSIONS
These results suggest that HLA class I antigens and TNF-alpha A-308G are not associated with susceptibility or resistance to the development of TDI-induced asthma.
Beghé
B
B
Section of Respiratory Diseases, Department of Clinical and Experimental Medicine,University of Padua, Padua, Italy.
Padoan
M
M
Moss
C T
CT
Barton
S J
SJ
Holloway
J W
JW
Holgate
S T
ST
Howell
W M
WM
Mapp
C E
CE
D000328:Adult; D001249:Asthma / Q000139:chemically induced / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000235:genetics; D011110:Polymorphism, Genetic; D011336:Probability; D011379:Prognosis; D012016:Reference Values; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D015395:Histocompatibility Antigens Class I; D014409:Tumor Necrosis Factor-alpha; D014051:Toluene 2,4-Diisocyanate