Cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa.
The cytotoxicity and antimicrobial activity of goniothalamin isolated from Bryonopsis laciniosa was investigated. Goniothalamin showed potent cytotoxicity with LC50 values (5.03 microg/mL) comparable with the reference standard agent, gallic acid. It also showed weak antibacterial and significant antifungal activity against a wide range of gram positive and gram negative bacteria and fungi. The antibacterial (minimum inhibitory concentration) effect against Bacillus cereus and Shigella shiga was found to be 64 microg/mL.
Mosaddik
M Ashik
MA
Centre for Phytochemistry, Southern Cross University, Lismore, NSW 2480, Australia. mamosaddik@yahoo.com
Haque
M Ekramul
ME
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001156:Artemia / Q000187:drug effects; D001409:Bacillus cereus / Q000187:drug effects*; D019662:Cucurbitaceae; D004305:Dose-Response Relationship, Drug; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007928:Lethal Dose 50; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D011753:Pyrones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012760:Shigella / Q000187:drug effects*
D000890:Anti-Infective Agents; D010936:Plant Extracts; D011753:Pyrones; C103280:goniothalamin