Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia.
An International Working Group met to revise the diagnostic and response criteria for acute myelogenous leukemia originally published in 1990, as well as to provide definitions of outcomes and reporting standards to improve interpretability of data and comparisons among trials. Since the original publication, there have been major advances in our understanding of the biology and molecular genetics of acute leukemia that are clinically relevant and warrant incorporation into response definitions. Differences from the 1990 recommendations included a category of leukemia-free state, new criteria for complete remission, including cytogenetic and molecular remissions and remission duration. Storage of viable blasts for correlative studies is important for future progress in the therapy of these disorders.
Cheson
Bruce D
BD
Department of Hematology/Oncology, Georgetown University, Lombardi Cancer Center, 3800 Reservoir Rd, NW, Washington, DC 20007, USA. bdc4@georgetown.edu
Bennett
John M
JM
Kopecky
Kenneth J
KJ
Büchner
Thomas
T
Willman
Cheryl L
CL
Estey
Elihu H
EH
Schiffer
Charles A
CA
Doehner
Hartmut
H
Tallman
Martin S
MS
Lister
T Andrew
TA
Lo-Coco
Francesco
F
Willemze
Roel
R
Biondi
Andrea
A
Hiddemann
Wolfgang
W
Larson
Richard A
RA
Löwenberg
Bob
B
Sanz
Miguel A
MA
Head
David R
DR
Ohno
Ryuzo
R
Bloomfield
Clara D
CD
LoCocco
Francesco
F
D002986:Clinical Trials as Topic / Q000592:standards*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000145:classification / Q000175:diagnosis* / Q000628:therapy; D012074:Remission Induction; D014481:United States