Randomized trial of an adherence programme for clients with HIV.
Our aim was to determine if a comprehensive adherence package improved self reported adherence to antiretroviral therapy. The adherence package included an education programme, individualized planning of regimens, and the opportunity for a patient to choose from a number of adherence aids and reminder devices. A randomized step wedge design was used. Forty-three individuals were randomized to begin the intervention over a five-month period. There was a substantial fall in the number of missed doses reported for the last four days (0.76 to 0.38, P =0.03) and last seven days (1.5 to 0.74, P =0.005) but not for the last 28 days (2.5 to 2.5, P =0.63). There was no statistical difference in the viral load or CD4 lymphocyte count in the period before or after the intervention. The Morisky score during the pre and post intervention periods was significantly different (P =0.006), 2.9 (SD 0.9) and 3.3 (SD 0.8) respectively. This adherence package improved self reported adherence during the last four and seven days.
Fairley
C K
CK
Department of Public Health, University of Melbourne, and Melbourne Sexual Health Centre, Melbourne, Australia. cfairley@unimelb.edu.au
Levy
R
R
Rayner
C R
CR
Allardice
K
K
Costello
K
K
Thomas
C
C
McArthur
C
C
Kong
D
D
Mijch
A
A
Melbourne Adherence Group
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D001315:Australia; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance / Q000706:statistics & numerical data*; D010353:Patient Education as Topic / Q000379:methods*; D015397:Program Evaluation; D017010:Reminder Systems; D011795:Surveys and Questionnaires
D019380:Anti-HIV Agents