Serum phospholipid transfer protein mass as a possible protective factor for coronary heart diseases.
BACKGROUND
Phospholipid transfer protein (PLTP) can generate pre-beta high-density lipoprotein (HDL), an efficient acceptor of peripheral cholesterol, by mediating a process called HDL conversion. The transfer of phospholipids to immature HDL is also essential in maintaining reverse cholesterol transport. The phospholipid transfer activity of PLTP has been associated with various patho-physiological conditions; however, little information is available concerning the relationship between PLTP mass and disease.


RESULTS
Using a sandwich enzyme-linked immunosorbent assay, PLTP concentration was measured and related to the risk of developing cardiovascular disease in a worksite-based cohort of Japanese men (n=2,567). Multiple linear regression analysis showed significant associations between PLTP and HDL cholesterol, triglycerides, low-density lipoprotein cholesterol, and body mass index (standardized beta=0.395, -0.191, -0.064, and -0.064, respectively; R(2)=0.31). During the follow-up period, there were 10 cases of coronary heart disease (CHD) and 7 of stroke. The multivariate adjusted relative risk of CHD was 0.46 (95% confidence interval, 0.20-1.07) for an increase of 1 standard deviation in the PLTP value (p=0.071). PLTP concentration was not related to the risk of stroke.


CONCLUSIONS
The results of this prospective study indicate that the serum PLTP concentration would serve as a predictor of CHD, independent of HDL cholesterol, triglycerides and other established risk factors.
Yatsuya
Hiroshi
H
Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine, Japan.
Tamakoshi
Koji
K
Hattori
Hiroaki
H
Otsuka
Rei
R
Wada
Keiko
K
Zhang
Huiming
H
Mabuchi
Tomoko
T
Ishikawa
Miyuki
M
Murata
Chiyoe
C
Yoshida
Tsutomu
T
Kondo
Takaaki
T
Toyoshima
Hideaki
H
D000428:Alcohol Drinking; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D015992:Body Mass Index; D002352:Carrier Proteins / Q000097:blood*; D015331:Cohort Studies; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007899:Leisure Activities; D008297:Male; D008565:Membrane Proteins / Q000097:blood*; D008875:Middle Aged; D015999:Multivariate Analysis; D016272:Occupational Health; D049294:Phospholipid Transfer Proteins; D012307:Risk Factors
D015415:Biomarkers; D002352:Carrier Proteins; D008565:Membrane Proteins; D049294:Phospholipid Transfer Proteins