[Contribution of selected factors of inflammatory creative process in the vascular endothelial damage in the diabetes patients].
Diabetes causes the development of atherosclerotic vascular changes. Leukocytes, thrombocytes and also cytokines are involved in this process via endothelial activation. Estimation of interleukin 1 beta (IL-1 beta) and fibrinogen serum level of patients suffering from diabetes in context of endothelial damage is presented. The stage of vascular endothelium damage is based on the measurement of blood endothelial cells (EC) count and concentration of the plasmatic von Willebrand factor (vWF). Endothelial destruction level was established on the base of selectin L, P and E serum concentration. Activation of inflammatory proliferative mechanisms was indicated by IL-1 beta serum level. Serum haemostasis disorders were indicated by fibrinogen concentration. Patients with diabetes t. 1 and t. 2 differentiated by age and diabetes duration time with normal blood pressure and hypertension were included into the research. We showed that in both types of diabetes endothelium damage goes with significant increase of circulated EC count and vWF concentration. Increased serum level of IL-1 beta and fibrinogen in those patients shoulds significant correlation with vascular wall destruction, visibly marked in patients with diabetes t. 2. Hiperfibrinogenaemia and increased IL-1 beta concentration associate with significant engagement of SL and SE in inflammatory proliferative process of endothelium in young people suffering from diabetes t. 1 over 6 years. Hypertension coexisting with essential disease in both types of diabetes remains important progression factor in atheromatic vascular changes.
Adamiec
Rajmund
R
Katedra i Klinika Angiologii, Nadciśnienia Tetniczego i Diabetologii AM we Wrocławiu.
Bednarska-Chabowska
Dorota
D
Adamiec
Joanna
J
Wdowczyk
Michał
M
D000328:Adult; D003920:Diabetes Mellitus / Q000276:immunology*; D004730:Endothelium, Vascular / Q000276:immunology* / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006973:Hypertension / Q000276:immunology*; D007249:Inflammation / Q000276:immunology* / Q000473:pathology*; D007375:Interleukin-1 / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D007375:Interleukin-1