Allergic disease after pediatric liver transplantation with systemic tacrolimus and cyclosporine a therapy.
Cyclosporine A (CsA) and tacrolimus (Tac), both calcineurin inhibitors, have been used extensively for immunosuppressive therapy in pediatric liver transplant recipients. They share a similar mechanism of action, the inhibition of cytokine gene transcription primarily interleukin-2 (IL-2) in T lymphocytes. Despite the strong immunosuppressive property, there are several reports of food allergy in pediatric transplant recipients under Tac immunosuppression, but not CsA. In this paper we report on 3 of 50 pediatric liver transplant recipients diagnosed with food allergy and asthma while receiving systemic Tac/CsA immunosuppression and the discuss the role of calcineurin inhibitors in this situation.
Arikan
C
C
Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ege University Organ Transplant and Research Center, 250 sok. Mustafa Cukur Sitesi B1 Blk., No: 6 D:1, 35500 Izmir, Turkey. arikan@med.ege.edu.tr
Kilic
M
M
Tokat
Y
Y
Aydogdu
S
S
D000293:Adolescent; D001249:Asthma / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005512:Food Hypersensitivity / Q000453:epidemiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016031:Liver Transplantation / Q000276:immunology*; D012189:Retrospective Studies; D016559:Tacrolimus / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D016559:Tacrolimus