title: Relapsing polychondritis.
abstract: Relapsing polychondritis is a unique, rare autoimmune disorder in which the cartilaginous tissues are the primary targets of destruction but the immune damage can spread to involve noncartilaginous tissues like the kidney, blood vessels, and so forth. The manifestations of the disease can take many different forms and the pathogenesis is still unclear. It may occur in a primary form or it may be associated with other disease states. This article summarizes important aspects of the disease with a focus on recent information regarding clinical manifestations, disease associations, pathogenesis, and advances in therapeutics.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 59905, USA.
authors.forename: Peter D
authors.initials: PD
authors.lastname: Kent
authors.forename: Clement J
authors.initials: CJ
authors.lastname: Michet
authors.forename: Harvinder S
authors.initials: HS
authors.lastname: Luthra
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008727:Methotrexate / Q000627:therapeutic use; D009422:Nervous System Diseases / Q000209:etiology; D011081:Polychondritis, Relapsing / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D011379:Prognosis; D012871:Skin Diseases / Q000209:etiology
chemical_list: D018501:Antirheumatic Agents; D005938:Glucocorticoids; D008727:Methotrexate