title: Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.
abstract: Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Abeta42 levels suggesting that a single locus may influence risk for AD by elevating plasma Abeta42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA. myersa@mail.nih.gov
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Myers
authors.forename: Helen
authors.initials: H
authors.lastname: Marshall
authors.forename: Peter
authors.initials: P
authors.lastname: Holmans
authors.forename: Danielle
authors.initials: D
authors.lastname: Compton
authors.forename: Richard J P
authors.initials: RJ
authors.lastname: Crook
authors.forename: Adrian P
authors.initials: AP
authors.lastname: Mander
authors.forename: Petra
authors.initials: P
authors.lastname: Nowotny
authors.forename: Scott
authors.initials: S
authors.lastname: Smemo
authors.forename: Melanie
authors.initials: M
authors.lastname: Dunstan
authors.forename: Luke
authors.initials: L
authors.lastname: Jehu
authors.forename: Jen C
authors.initials: JC
authors.lastname: Wang
authors.forename: Marian
authors.initials: M
authors.lastname: Hamshere
authors.forename: John C
authors.initials: JC
authors.lastname: Morris
authors.forename: Joanne
authors.initials: J
authors.lastname: Norton
authors.forename: Sumi
authors.initials: S
authors.lastname: Chakraventy
authors.forename: Nigel
authors.initials: N
authors.lastname: Tunstall
authors.forename: Simon
authors.initials: S
authors.lastname: Lovestone
authors.forename: Ronald
authors.initials: R
authors.lastname: Petersen
authors.forename: Michael
authors.initials: M
authors.lastname: O'Donovan
authors.forename: Lesley
authors.initials: L
authors.lastname: Jones
authors.forename: Julie
authors.initials: J
authors.lastname: Williams
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owen
authors.forename: John
authors.initials: J
authors.lastname: Hardy
authors.forename: Alison
authors.initials: A
authors.lastname: Goate
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D014568:Urokinase-Type Plasminogen Activator / Q000235:genetics*
chemical_list: D014568:Urokinase-Type Plasminogen Activator