Cytokine antibody arrays: a promising tool to identify molecular targets for drug discovery.
Cytokines play important roles in normal cell functions and changes in cytokines have been implicated in many diseases. Recent efforts have focused on developing cytokine antibody arrays. These arrays allow investigators to simultaneously detect multiple cytokines in qualitative and quantitative ways. Cytokine antibody array systems feature high sensitivity, specificity and throughput. This novel technology opens up an expanding spectrum of applications in drug discovery, including target discovery, target validation, screening for lead compounds, compound optimization and clinical trials.
Huang
Ruo-Pan
RP
Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Woodruff Memorial Research Building Rm. 4219, 1639 Pierce Drive, Atlanta, GA 30322, USA. rhuang@emory.edu
D000906:Antibodies / Q000378:metabolism*; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D015195:Drug Design; D015870:Gene Expression; D006801:Humans; D007118:Immunoassay / Q000379:methods*; D040081:Protein Array Analysis / Q000379:methods*
D000906:Antibodies; D016207:Cytokines