title: E-MSD: an integrated data resource for bioinformatics.
abstract: The Macromolecular Structure Database (MSD) group (http://www.ebi.ac.uk/msd/) continues to enhance the quality and consistency of macromolecular structure data in the Protein Data Bank (PDB) and to work towards the integration of various bioinformatics data resources. We have implemented a simple form-based interface that allows users to query the MSD directly. The MSD 'atlas pages' show all of the information in the MSD for a particular PDB entry. The group has designed new search interfaces aimed at specific areas of interest, such as the environment of ligands and the secondary structures of proteins. We have also implemented a novel search interface that begins to integrate separate MSD search services in a single graphical tool. We have worked closely with collaborators to build a new visualization tool that can present both structure and sequence data in a unified interface, and this data viewer is now used throughout the MSD services for the visualization and presentation of search results. Examples showcasing the functionality and power of these tools are available from tutorial webpages (http://www. ebi.ac.uk/msd-srv/docs/roadshow_tutorial/).
authors.affiliation: EMBL Outstation, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
authors.forename: A
authors.initials: A
authors.lastname: Golovin
authors.forename: T J
authors.initials: TJ
authors.lastname: Oldfield
authors.forename: J G
authors.initials: JG
authors.lastname: Tate
authors.forename: S
authors.initials: S
authors.lastname: Velankar
authors.forename: G J
authors.initials: GJ
authors.lastname: Barton
authors.forename: H
authors.initials: H
authors.lastname: Boutselakis
authors.forename: D
authors.initials: D
authors.lastname: Dimitropoulos
authors.forename: J
authors.initials: J
authors.lastname: Fillon
authors.forename: A
authors.initials: A
authors.lastname: Hussain
authors.forename: J M C
authors.initials: JM
authors.lastname: Ionides
authors.forename: M
authors.initials: M
authors.lastname: John
authors.forename: P A
authors.initials: PA
authors.lastname: Keller
authors.forename: E
authors.initials: E
authors.lastname: Krissinel
authors.forename: P
authors.initials: P
authors.lastname: McNeil
authors.forename: A
authors.initials: A
authors.lastname: Naim
authors.forename: R
authors.initials: R
authors.lastname: Newman
authors.forename: A
authors.initials: A
authors.lastname: Pajon
authors.forename: J
authors.initials: J
authors.lastname: Pineda
authors.forename: A
authors.initials: A
authors.lastname: Rachedi
authors.forename: J
authors.initials: J
authors.lastname: Copeland
authors.forename: A
authors.initials: A
authors.lastname: Sitnov
authors.forename: S
authors.initials: S
authors.lastname: Sobhany
authors.forename: A
authors.initials: A
authors.lastname: Suarez-Uruena
authors.forename: G J
authors.initials: GJ
authors.lastname: Swaminathan
authors.forename: M
authors.initials: M
authors.lastname: Tagari
authors.forename: S
authors.initials: S
authors.lastname: Tromm
authors.forename: W
authors.initials: W
authors.lastname: Vranken
authors.forename: K
authors.initials: K
authors.lastname: Henrick
mesh_terms: D000465:Algorithms; D000818:Animals; D019295:Computational Biology; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D008024:Ligands; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D014584:User-Computer Interface
chemical_list: D008024:Ligands; D011506:Proteins