Influence of Th1, Th2, and Th3 cytokines during the early phase after liver transplantation.
To investigate the change of Th1, Th2, Th3 cytokines during early liver transplantation. IFN-r, IL-4, TGF-beta production by CD4+ T cells were determined by fluorescence activated cell sorter analysis. Comparing the acute rejection with the non-acute rejection groups on the 7th, 14th, and 28th day showed that high interferon-gamma production associated with acute rejection in the early posttransplant period. There was no evidence of significant changes in interleukin-4 and transforming growth factor beta (TGF-beta) levels between non-acute rejection groups with acute rejection groups. Th1 cytokine high production is significantly associated with acute rejection in liver transplant recipients.
Wang
Y-l
YL
Tianjin Institute of Thrombosis and Hemostasis, Organ Transplantation Center of Tianjin, First Central Hospital, 24 Fukang Road, Tianjin 300-192, P.R. China. wang_yu_l@yahoo.com.cn
Tang
Z-q
ZQ
Gao
W
W
Jiang
Y
Y
Zhang
X-h
XH
Peng
L
L
D016516:CD4-CD8 Ratio; D002478:Cells, Cultured; D016207:Cytokines / Q000097:blood*; D005260:Female; D005434:Flow Cytometry; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D016031:Liver Transplantation / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D013997:Time Factors; D016212:Transforming Growth Factor beta / Q000097:blood
D016207:Cytokines; D016212:Transforming Growth Factor beta; D015847:Interleukin-4; D007371:Interferon-gamma