title: An autopsy study of hypertrophic cardiomyopathy.
abstract: OBJECTIVE
  To see the pathological features of this disease in our set up and to emphasise the importance of morphological examination in making the diagnosis of hypertrophic cardiomyopathy (HCM) especially in cases of sudden cardiac death.
  
  
  METHODS
  A retrospective, descriptive study of 15 autopsies of this particular disease was carried out at the Armed Forces Institute of Pathology (AFI) Rawalpindi during the period from 1990 to 1995. The hearts along with blood vessels were fixed in 10% formalin and were dissected according to the modified Virchow's method for eliciting the gross appearance of cardiac chambers and valves. Representative sections were taken for histological examination.
  
  
  RESULTS
  All the cases were young adult males. The age range was from 17-34 years (mean, 26-6 years). Ten cases died suddenly and five cases had an evidence of moderate to severe exertion preceding their death. Symmetrical as well as asymmetrical hypertrophy was noted in this study. The thickness of inter ventricular septum (mean 20 mm) and left ventricular wall (mean 22.5 mm) was increased. All the specimens revealed disarray of hypertrophic myocardial fibres and patchy interstitial fibroses.
  
  
  CONCLUSIONS
  Sudden death is usually the first manifestation of disease. The hearts showed asymmetric as well as concentric hypertrophy. Myofibre hypertrophy and disarray was an important pathological findings in our cases. While carrying out post-mortem examination of a case of sudden cardiac death one should also keep in mind the possibility of this disease.
authors.affiliation: Department of Pathology, Army Medical College Abid Majid Road, Rawalpindi.
authors.forename: M
authors.initials: M
authors.lastname: Ahmad
authors.forename: S
authors.initials: S
authors.lastname: Afzal
authors.forename: I A
authors.initials: IA
authors.lastname: Malik
authors.forename: S
authors.initials: S
authors.lastname: Mushtaq
authors.forename: A
authors.initials: A
authors.lastname: Mubarik
mesh_terms: D000293:Adolescent; D000328:Adult; D001344:Autopsy; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis / Q000473:pathology*; D016757:Death, Sudden, Cardiac / Q000473:pathology; D006801:Humans; D008297:Male; D009206:Myocardium / Q000473:pathology; D012189:Retrospective Studies