The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.
Microbial pathogens use a variety of their surface molecules to bind to host extracellular matrix (ECM) components to establish an effective infection. However, ECM components can also serve as an integral part of the innate immunity. Mice lacking expression of mindin (spondin 2), a highly conserved ECM protein, have an impaired ability to clear bacterial infection, and mindin-deficient macrophages show defective responses to a broad spectrum of microbial stimuli. Moreover, mindin binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Thus, mindin is essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens.
He
You-Wen
YW
Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA. he000004@mc.duke.edu
Li
Hong
H
Zhang
Jun
J
Hsu
Chia-Lin
CL
Lin
Emily
E
Zhang
Nu
N
Guo
Jian
J
Forbush
Katherine A
KA
Bevan
Michael J
MJ
D000595:Amino Acid Sequence; D000818:Animals; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D005109:Extracellular Matrix / Q000276:immunology*; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000276:immunology*; D005260:Female; D006090:Gram-Negative Bacteria / Q000276:immunology* / Q000472:pathogenicity; D016905:Gram-Negative Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D006094:Gram-Positive Bacteria / Q000276:immunology* / Q000472:pathogenicity; D016908:Gram-Positive Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000276:immunology / Q000382:microbiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D013682:Teichoic Acids / Q000276:immunology
D016207:Cytokines; D016326:Extracellular Matrix Proteins; D008070:Lipopolysaccharides; D013682:Teichoic Acids; C121491:mindin; C009900:lipoteichoic acid