title: An infant with systemic hypertension, renal artery stenosis, and neuroblastoma.
abstract: A newborn girl with neuroblastoma presented with hypertension (blood pressure 200/140 mm Hg). The concentration of active renin in the ipsilateral renal vein was exceedingly high compared with those in the other venous systems, and angiography results showed narrowing of the contralateral 2 renal arteries. The tumor regressed in size after chemotherapy, but the blood pressure remained high. Percutaneous transluminal angioplasty (PTA) for the left renal arteries was performed twice, the first one at 5 months of age, which achieved some success in the recovery of impaired kidney function. At 8 months of age, she underwent radical resection of the neuroblastoma and removal of the right kidney, and the blood pressure promptly returned to normal postoperatively. The current patient represents the second youngest, well-documented case of renovascular hypertension with neuroblastoma in early infancy.
authors.affiliation: Division of Cardiology, Gunma Children's Medical Center, Gunma, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Shinohara
authors.forename: Toshiji
authors.initials: T
authors.lastname: Shitara
authors.forename: Shin-itsu
authors.initials: SI
authors.lastname: Hatakeyama
authors.forename: Norio
authors.initials: N
authors.lastname: Suzuki
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Maruyama
authors.forename: Tohru
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Tsuchida
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications*; D000450:Aldosterone / Q000097:blood; D001806:Blood Urea Nitrogen; D002395:Catecholamines / Q000097:blood; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000209:etiology*; D007231:Infant, Newborn; D009447:Neuroblastoma / Q000150:complications*; D012078:Renal Artery Obstruction / Q000150:complications*; D012083:Renin / Q000097:blood
chemical_list: D002395:Catecholamines; D000450:Aldosterone; D012083:Renin