Comparison of in vitro activities of ketolides, macrolides, and an azalide against the spirochete Borrelia burgdorferi.
Two ketolides, three macrolides, and one azalide were tested in vitro against 17 isolates of the B. burgdorferi s.l. complex. As measured in micrograms per milliliter, activity was highest for cethromycin (MIC at which 90% of the tested isolates were inhibited [MIC(90)], 0.0019 micro g/ml) and telithromycin (MIC(90), 0.0078 micro g/ml). Electron-microscope analysis and time-kill studies also supported enhanced effectiveness of both ketolides.
Hunfeld
Klaus-Peter
KP
Institute of Medical Microbiology, University Hospital of Frankfurt, D-60596 Frankfurt/Main, Germany. k.hunfeld@em.uni-frankfurt.de
Wichelhaus
Thomas A
TA
Rödel
Rebecca
R
Acker
Georg
G
Brade
Volker
V
Kraiczy
Peter
P
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology*; D025065:Borrelia burgdorferi / Q000187:drug effects* / Q000648:ultrastructure; D004917:Erythromycin / Q000031:analogs & derivatives / Q000494:pharmacology; D006801:Humans; D048628:Ketolides; D008193:Lyme Disease / Q000382:microbiology; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001372:Aza Compounds; D048628:Ketolides; D018942:Macrolides; D004917:Erythromycin; C405499:cethromycin; C106791:telithromycin