title: The Genomic Threading Database: a comprehensive resource for structural annotations of the genomes from key organisms.
abstract: Currently, the Genomic Threading Database (GTD) contains structural assignments for the proteins encoded within the genomes of nine eukaryotes and 101 prokaryotes. Structural annotations are carried out using a modified version of GenTHREADER, a reliable fold recognition method. The Gen THREADER annotation jobs are distributed across multiple clusters of processors using grid technology and the predictions are deposited in a relational database accessible via a web interface at http://bioinf.cs.ucl.ac.uk/GTD. Using this system, up to 84% of proteins encoded within a genome can be confidently assigned to known folds with 72% of the residues aligned. On average in the GTD, 64% of proteins encoded within a genome are confidently assigned to known folds and 58% of the residues are aligned to structures.
authors.affiliation: Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK.
authors.forename: Liam J
authors.initials: LJ
authors.lastname: McGuffin
authors.forename: Stefano A
authors.initials: SA
authors.lastname: Street
authors.forename: Kevin
authors.initials: K
authors.lastname: Bryson
authors.forename: Søren-Aksel
authors.initials: SA
authors.lastname: Sørensen
authors.forename: David T
authors.initials: DT
authors.lastname: Jones
mesh_terms: D000818:Animals; D019295:Computational Biology; D030541:Databases, Genetic; D016678:Genome; D023281:Genomics; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000235:genetics*; D020543:Proteome / Q000737:chemistry / Q000235:genetics; D040901:Proteomics; D012984:Software
chemical_list: D011506:Proteins; D020543:Proteome