New cytotoxic steroidal alkaloids from the Philippine sponge Corticium niger.
Four new steroidal alkaloids, plakinamine I-K (1-3) and dihydroplakinamine K (4), were isolated from the marine sponge Corticium niger. The structures of these compounds were elucidated by interpretation of spectroscopic data. Compounds 1-4 exhibit significant in vitro cytotoxicity.
Ridley
Christian P
CP
Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212F, USA cridley@ucsd.edu.
Faulkner
D John
DJ
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010679:Philippines; D011161:Porifera / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000470:Alkaloids; D000970:Antineoplastic Agents; D013256:Steroids; C482748:dihydroplakinamine K; C482749:plakinamine I; C482751:plakinamine J; C482750:plakinamine K