title: Gender differences in response to differing antidepressant drug classes: two negative studies.
abstract: BACKGROUND
  A recent US study presented data suggesting that depressed women are more likely to respond to selective serotonin reuptake inhibitor (SSRI) than tricyclic (TCA) antidepressant drug therapies. We have undertaken replication studies in two independent databases.
  
  
  METHODS
  We have examined for gender differences in SSRI and TCA antidepressant response in both retrospective and prospective naturalistic uncontrolled studies, and in subsets of melancholic and non-melancholic depressed subjects. As the US study had indicated that women under the age of 40 years were particularly likely to show a differential response to SSRIs, we examined for age, gender and interactional effects. In addition, we examined for differential SSRI and TCA responsiveness in a subset of patients who had received drugs from both classes.
  
  
  RESULTS
  We failed to find evidence of women having a preferential response to SSRI medication or, conversely, of men having a superior response to TCA medication. Older age, however, was associated with a superior TCA response and younger age with a superior SSRI response.
  
  
  CONCLUSIONS
  As few studies have examined for differential gender and age effects in response to narrow action and broad action antidepressant drugs across major depressive subtypes, gender differential effects remain to be established.
authors.affiliation: Mood Disorders Unit, Black Dog Institute, Prince of Wales Hospital, Sydney, NSW, Australia.
authors.forename: G
authors.initials: G
authors.lastname: Parker
authors.forename: K
authors.initials: K
authors.lastname: Parker
authors.forename: M P
authors.initials: MP
authors.lastname: Austin
authors.forename: P
authors.initials: P
authors.lastname: Mitchell
authors.forename: H
authors.initials: H
authors.lastname: Brotchie
mesh_terms: D000328:Adult; D000367:Age Factors; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D001315:Australia; D003866:Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015203:Reproducibility of Results; D012189:Retrospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D012737:Sex Factors; D016896:Treatment Outcome; D014481:United States
chemical_list: D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D017367:Selective Serotonin Reuptake Inhibitors