title: Intravitreal r-TPA and gas injection in traumatic submacular hemorrhage.
abstract: OBJECTIVE
  To present the technique and efficiency of intravitreal recombinant tissue plasminogen activator (r-TPA) and gas injection in acute submacular hemorrhage (SMH) due to traumatic choroidal rupture.
  
  
  METHODS
  0.4 ml of sulfur hexafluoride was injected into the vitreous cavity in 2 patients with SMH due to traumatic choroidal rupture. In 1 patient gas injection was combined with 50 microg r-TPA. Both patients were closely followed.
  
  
  RESULTS
  Preoperative visual acuity was 20/125 in one eye and 20/100 in the other. At the end of the follow-up, visual acuity had improved to 20/32 in both eyes.
  
  
  CONCLUSIONS
  r-TPA and gas injection into the vitreous body may be an efficient therapy in patients with submacular hemorrhage due to choroidal rupture.
authors.affiliation: Department of Ophthalmology, Christian Albrechts University Kiel, Kiel, Germany. dholland@ophthalmol.uni-kiel.de
authors.forename: Detlef
authors.initials: D
authors.lastname: Holland
authors.forename: Burkhard
authors.initials: B
authors.lastname: Wiechens
mesh_terms: D000328:Adult; D002829:Choroid / Q000293:injuries*; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D005740:Gases / Q000008:administration & dosage*; D006801:Humans; D007267:Injections; D008266:Macula Lutea; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage; D012166:Retinal Hemorrhage / Q000473:pathology / Q000601:surgery*; D012421:Rupture; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D014822:Vitreous Body; D014949:Wounds, Nonpenetrating / Q000150:complications*
chemical_list: D005343:Fibrinolytic Agents; D005740:Gases; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator