Mutant p53 protein in the serum of patients with cervical carcinoma: correlation with the level of serum epidermal growth factor receptor and prognostic significance.
We have previously reported that the serum level of epidermal growth factor receptor (EGFR) was significantly elevated in 38 cervical carcinoma patients. The levels of mutant p53 protein were determined in the serum of the same cohort (invasive or recurrent carcinoma: 26, carcinoma in situ (CIS): 12) and 18 controls using ELISA. The median serum level for mutant p53 in cervical carcinoma patients (0.11 ng/ml; range, 0-2.66 ng/ml) demonstrated no significant difference compared to that of controls (0.14 ng/ml; range, 0-0.34 ng/ml) (P=0.324). Serum mutant p53 showed positive elevation in 5 patients with invasive or recurrent carcinoma (19%) and 1 with CIS (8%). A significant correlation was found between EGFR and mutant p53 levels (r=0.668; P<0.0001). In invasive or recurrent cervical carcinoma, positive mutant p53 was significantly associated with poor overall survival in both univariate (P=0.035) and multivariate (P=0.046) analysis, while increased level of EGFR did not show prognostic significance (P=0.755). Serum mutant p53 could have potential usefulness as a biological marker of cervical carcinoma for prediction of prognosis and follow-up after treatment.
Oh
Min-Jeong
MJ
Department of Obstetrics and Gynecology, Kuro Hospital, Korea University College of Medicine, 80 Kuro-Dong, Kuro-Gu, 152-050 Seoul, South Korea.
Choi
Jin-Hyuk
JH
Lee
Yong Ho
YH
Lee
Jae Kwan
JK
Hur
Joon Young
JY
Park
Yong Kyun
YK
Lee
Kyu Wan
KW
Chough
Soo Yong
SY
Saw
Ho-Suk
HS
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000097:blood / Q000401:mortality; D066246:ErbB Receptors / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009154:Mutation; D011379:Prognosis; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000097:blood*; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000401:mortality
D016159:Tumor Suppressor Protein p53; D066246:ErbB Receptors