New cinnamylphenols from Dalbergia species with cancer chemopreventive activity.
Five new cinnamylphenols (1,3-diphenylpropenes), dalberatins A (1), B (2), C (3), D (4), and E (5), were isolated from plants of the Dalbergia species. They were characterized and tested for their inhibitory activities against Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. The cinnamylphenols were found to show remarkably potent activities. The result of the present investigation indicated that some of these cinnamylphenols might be valuable as potential cancer chemopreventive agents (anti-tumor promoters).
Ito
Chihiro
C
Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan.
Itoigawa
Masataka
M
Kanematsu
Tetsufumi
T
Ruangrungsi
Nijsiri
N
Higashihara
Hiroshi
H
Tokuda
Harukuni
H
Nishino
Hoyoku
H
Furukawa
Hiroshi
H
D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000956:Antigens, Viral / Q000187:drug effects; D035782:Dalbergia / Q000737:chemistry*; D006801:Humans; D016393:Lymphoma, B-Cell; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013785:Thailand
D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D010636:Phenols; D013755:Tetradecanoylphorbol Acetate