Abdominal fat and sympathetic overactivity. From calorie intake to postmenopausal hypertension.
BACKGROUND
Epidemiologic studies have found an association between overweight and increased mortality arising primarily from cardiovascular disorders. A major determinant is a chronically raised sympathetic nervous system activity which can arise from calorie intake-dependent and -independent mechanisms. Calorie-dependent parameters reflecting sympathetic overactivity are an increased body fat mass and body mass index.
Although influenced by calorie intake to a certain extent, visceral fat accumulation is a mechanism which is determined also by estrogen deficiency (postmenopausal hypertension) or enhanced corticoid influences. It is hypothesized that excess catecholamines trigger various adverse processes which, if they persist, can lead or aggravate hypertension and insulin resistance. Visceral but not peripheral fat mass was correlated with atherogenic metabolites.
The present focus on visceral fat accumulation strengthens the concept of an "excess catecholamine syndrome" of which the "metabolic syndrome" appears as one consequence. It is proposed to further assess the potential of transthoracic echocardiography as routine imaging method for the prediction of visceral fat accumulation and its adverse health consequences.
Rupp
Heinz
H
Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University Marburg, Germany. Rupp@staff.uni-marburg.de
Maisch
Bernhard
B
D000005:Abdomen; D001161:Arteriosclerosis / Q000503:physiopathology; D001823:Body Composition / Q000502:physiology*; D001824:Body Constitution / Q000502:physiology*; D015992:Body Mass Index; D002395:Catecholamines / Q000502:physiology; D002149:Energy Intake / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007333:Insulin Resistance / Q000502:physiology; D009765:Obesity / Q000503:physiopathology*; D017698:Postmenopause / Q000502:physiology*; D012307:Risk Factors; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D002395:Catecholamines