Prognostic value of cardiac autonomic neuropathy independent and incremental to perfusion defects in patients with diabetes and suspected coronary artery disease.
We investigated the prognostic value of cardiac autonomic neuropathy (CAN) in relation to perfusion defects in 146 diabetic patients with suspected coronary artery disease. Perfusion defects and CAN were significant univariate predictors of death (p=0.05 and p<0.001, respectively) and cardiac events (p<0.001 and p<0.002, respectively). However, CAN remained a significant predictor of death and cardiac events after adjustment for perfusion defects (both p<0.02), and provided prognostic information incremental to that offered by perfusion defects alone (p<0.003 and p<0.006, respectively).
Lee
Kyung-Han
KH
Department of Nuclear Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea.
Jang
Hong-Joo
HJ
Kim
Young-Hwan
YH
Lee
Eun Jung
EJ
Choe
Yearn Seong
YS
Choi
Yong
Y
Lee
Mun Gyu
MG
Lee
Sang Hoon
SH
Kim
Byung-Tae
BT
D000367:Age Factors; D000368:Aged; D003324:Coronary Artery Disease / Q000150:complications / Q000503:physiopathology*; D003326:Coronary Circulation / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006321:Heart / Q000294:innervation*; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000209:etiology / Q000401:mortality / Q000503:physiopathology; D011237:Predictive Value of Tests; D011379:Prognosis; D012044:Regression Analysis; D013997:Time Factors