[Central and peripheral nerve disorder induced by interferon alpha therapy for renal cell carcinoma].
Interferon alpha (IFN-alpha) therapy was conducted for a male patient aged 70 years old, who underwent a two-stage radical nephrectomy for bilateral renal cell carcinoma with multiple pulmonary metastasis. He was hospitalized due to leg weakness and disorientation 45 days after this treatment was started. We discontinued INF-alpha therapy immediately after neurologists indicated the disorder of the central and the peripheral nervous systems induced by the administration of this cytokine. Steroid pulse therapy was effective to resolve the patient's neurological symptoms. To our knowledge, this is the first case of the side effects on both central and peripheral nervous systems by IFN-alpha therapy for renal cell carcinoma.
Kato
Karen
K
Department of Urology, Iwate University School of Medicine.
Omori
So
S
Tanaka
Takanao
T
Komatsu
Sunao
S
Seo
Takashi
T
Sugimura
Jun
J
Konda
Ryuichirou
R
Yamazaki
Etsuko
E
Fujioka
Tomoaki
T
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy*; D002493:Central Nervous System Diseases / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000188:drug therapy; D020551:Pulse Therapy, Drug
D000970:Antineoplastic Agents; D016898:Interferon-alpha; D008775:Methylprednisolone