title: A mitochondrial DNA variant associated with left ventricular hypertrophy in diabetes.
abstract: Diabetes was reported to be associated with a mitochondrial (mt) DNA mutation at 3243 and variants at 1310, 1438, 3290, 3316, 3394, 12,026, 15,927, and 16,189. Among these mtDNA abnormalities, those at 3243, 3316, 15,927, and 16,189 were also suggested to cause cardiomyopathies. We investigated the prevalence of such mtDNA abnormalities in 68 diabetic patients with LV hypertrophy (LVH), 100 without LVH, and 100 controls. Among the 9 mtDNA abnormalities, those at 3243, 3316, and 15,927 tended to be more prevalent in diabetic patients with LVH than in those without LVH (1%, 1%, and 4% vs. 0%, 0%, and 0%). Notably, the variant at 16,189 was more prevalent in diabetic patients with LVH than without LVH (46% vs. 24%, [Formula: see text] ). The odds ratio for LVH was 3.0 (95% CI, 1.5-6.1) for the 16,189 variant. A common mtDNA variant at 16,189 was found to be associated with LVH in diabetic patients.
authors.affiliation: The Heart Institute of Japan, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Momiyama
authors.forename: Michiko
authors.initials: M
authors.lastname: Furutani
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Reiko
authors.initials: R
authors.lastname: Ohmori
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Imamura
authors.forename: Atsuko
authors.initials: A
authors.lastname: Mokubo
authors.forename: Takayuki
authors.initials: T
authors.lastname: Asahina
authors.forename: Chisato
authors.initials: C
authors.lastname: Murata
authors.forename: Kiyoe
authors.initials: K
authors.lastname: Kato
authors.forename: Sonoko
authors.initials: S
authors.lastname: Anazawa
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hosokawa
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Atsumi
authors.forename: Kempei
authors.initials: K
authors.lastname: Matsuoka
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Kimura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kasanuki
authors.forename: Fumitaka
authors.initials: F
authors.lastname: Ohsuzu
authors.forename: Rumiko
authors.initials: R
authors.lastname: Matsuoka
mesh_terms: D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000097:blood / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D014644:Genetic Variation; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged
chemical_list: D004272:DNA, Mitochondrial