Neurons and brain macrophages regulate connexin expression in cultured astrocytes.
Neurons and brain macrophages (BM), respectively, increase and inhibit gap junctional communication (GJC) and connexin expression in cultured astrocytes. Thus, in brain diseases and injuries, neuronal death associated with the BM activation may decrease GJC in astrocytes and therefore have a physiopathological relevance.
Koulakoff
Annette
A
INSERM U114, Collège de France, Paris, France.
Même
William
W
Calvo
Charles-Felix
CF
Ezan
Pascal
P
Rouach
Nathalie
N
Giaume
Christian
C
D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism*; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D002450:Cell Communication / Q000502:physiology; D017630:Connexins / Q000378:metabolism*; D017629:Gap Junctions / Q000378:metabolism; D008264:Macrophages / Q000166:cytology / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*
D017630:Connexins