Influenza-induced rhabdomyolysis after autologous peripheral blood stem cell transplantation for malignant lymphoma.
We report influenza-induced rhabodmyolysis and congestive heart failure after high-dose therapy and hematopoietic stem cell transplantation for malignant lymphoma. Four months after autologous peripheral blood stem cell transplantation for the treatment of malignant lymphoma, a 65-year-old Japanese man developed acute congestive heart failure requiring artificial ventilation and rahbdomyolysis. Since influenza A virus was documented from his nasal cavity, he was diagnosed as rhabdomyolysis and congestive heart failure induced by influenza A infection. Neuraminidase inhibitor (oseltamivir 150 mg/ day for 5 days) was administrated, and heart failure and respiratory status were improved. Our experience suggests that early treatment with neuraminidase inhibitor may improve the clinical outcome of influenza-induced rhabdomyolysis and congestive heart failure.
Nozoe
Masatsugu
M
Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582.
Iino
Tadafumi
T
Nagafuji
Koji
K
Miyamoto
Toshihiro
T
Ito
Hiroyuki
H
Gondo
Hisashi
H
Harada
Mine
M
D000081:Acetamides / Q000627:therapeutic use; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D006333:Heart Failure / Q000821:virology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D009980:Influenza A virus; D016399:Lymphoma, T-Cell / Q000601:surgery*; D008297:Male; D009976:Orthomyxoviridae Infections / Q000188:drug therapy; D053139:Oseltamivir; D036102:Peripheral Blood Stem Cell Transplantation; D012206:Rhabdomyolysis / Q000821:virology*; D014182:Transplantation, Autologous
D000081:Acetamides; D000998:Antiviral Agents; D053139:Oseltamivir