[Drug correction of myocardial ischemia in patients with chronic obstructive bronchitis].
To compare the impact of therapy with dialtiazem and enapril on myocardial ischemia, this randomized study included 25 patients with chronic obstructive bronchitis and myocardial ischemia. A comparative assessment of the results of therapy showed a uniform time course of changes in the parameters of Holter monitoring and bicycle ergometry (BEM). In a group of patients receiving dialthizem, there were reduces in the number of episodes of painful and silent ischemia by 66.6 and 72.2%, respectively; the duration of myocardial ischemia and the value of the maximum ST depression decreased by 47.4%. In patients receiving enalapril, the episodes of painful and silent ischemia became fewer by 55.9 and 63.6%, respectively; the duration of ischemia and the value of the maximum ST depression decreased by 46 and 43%, respectively.
Chicherina
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EN
Malykh
S V
SV
D000328:Adult; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D029481:Bronchitis, Chronic / Q000150:complications* / Q000503:physiopathology; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004110:Diltiazem / Q000008:administration & dosage / Q000627:therapeutic use; D004452:Echocardiography; D004562:Electrocardiography; D015716:Electrocardiography, Ambulatory; D004656:Enalapril / Q000008:administration & dosage / Q000627:therapeutic use; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors; D016896:Treatment Outcome
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D002317:Cardiovascular Agents; D004656:Enalapril; D004110:Diltiazem