[Genetics and congenital heart diseases].
We describe in this article the recent data on the genetics of congenital heart defects (CHD) organised by type of CHD although each predisposing genetic factor is associated with a whole variety of CHD types. The recent progress resulting from animal models, molecular cytogenetics and CHD familial cases studies allow a better understanding of the determinism of CHD. This lead in term to improved counselling of parents of affected children and of CHD adults who would like to become parents. Nevertheless, more progress is needed to reach a better accuracy in prediction.
Sassolas
F
F
Service de cardiologie pédiatrique, hôpital Louis Pradel, 28, avenue du Doyen-Lépine, 69500 Bron.
Akhavi
A
A
Mestrallet
C
C
Raboisson
M J
MJ
Di Filippo
S
S
Bozio
A
A
Bouvagnet
P
P
D000328:Adult; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000235:genetics; D002648:Child; D004195:Disease Models, Animal; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006228:Hand Deformities, Congenital / Q000235:genetics*; D006801:Humans; D011237:Predictive Value of Tests