A piglet model for studies of gastrointestinal uptake of cadmium in neonates.
Newborns are believed to have a higher gastrointestinal uptake of inorganic cadmium (Cd) than adults. However, relevant models for investigations of absorption of dietary Cd in neonates are lacking. In the present study, piglets were exposed to 2 or 20 microg Cd/kg body weight (b wt) per day by repeated oral administrations of CdCl2 dissolved in deionized water or infant follow-up formula from days 0 to 10. Elevated and dose-dependent Cd retention in blood and tissues resulted from this low-dose Cd exposure, as determined at day 11. Follow-up formula reduced Cd uptake in comparison to deionized water. However, Cd distribution to the kidneys was higher when Cd was given in formula than in water. Metallothionein (MT) levels in liver, kidney and duodenum were six, three and two times higher, respectively compared to an un-exposed control. Differences in bioavailability and distribution of low-dose Cd given in various diets to newborns could be detected by the proposed piglet model.
Eklund
Gunilla
G
Department of Pharmacology and Toxicology, Swedish University of Agricultural Sciences, BMC, SE-751 23 Uppsala, Sweden. gunilla.eklund@farmtox.slu.se
Tallkvist
Jonas
J
Oskarsson
Agneta
A
D000818:Animals; D000831:Animals, Newborn; D015153:Blotting, Western; D001835:Body Weight; D002104:Cadmium / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity; D002105:Cadmium Poisoning / Q000378:metabolism*; D004064:Digestive System / Q000187:drug effects / Q000378:metabolism*; D004386:Duodenum / Q000737:chemistry / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D007082:Ileum / Q000737:chemistry / Q000378:metabolism; D041943:Infant Formula / Q000378:metabolism; D007501:Iron / Q000378:metabolism; D007668:Kidney / Q000737:chemistry / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008668:Metallothionein / Q000378:metabolism; D023421:Models, Animal; D013552:Swine; D015032:Zinc / Q000378:metabolism
D002104:Cadmium; D008668:Metallothionein; D007501:Iron; D015032:Zinc