title: [The relationship between glutathione S-transferase M1 genotypes and lipid peroxidation in asbestos workers].
abstract: OBJECTIVE
  To study the relationship between glutathione S-transferase M1 (GSTM1) genotypes and lipid peroxidation of asbestos workers.
  
  
  METHODS
  94 asbestos workers and 51 controls were selected as subjects. The general information, occupational history and individual habits were collected by questionnaires in all participants. The venous blood was sampled and the plasma was separated for the detection of malondialdehyde (MDA) level and lymphocytes for DNA isolation and GSTM1 genotyping.
  
  
  RESULTS
  MDA level was significantly higher in asbestos workers [(0.283 +/- 0.054) nmol/L] than that in controls [(0.163 +/- 0.053) nmol/L, P < 0.01], however, neither duration of exposure nor accumulated asbestos exposure dose was related to MDA levels; MDA levels in control workers with GSTM1 +/- genotype [(0.190 +/- 0.034) nmol/L] were significantly higher than that in control workers with GSTM1 +/+ genotype [(0.138 +/- 0.055) nmol/L, P < 0.01]. Among asbestos workers, the same trend could be found, but the differences was not significant(P > 0.05). When the workers were stratified by duration of exposure or accumulated asbestos exposure dose, MDA levels in individuals with GSTM1 -/- genotype were also higher than those with GSTM1 +/+ genotype, but the differences were also not significant(P > 0.05).
  
  
  CONCLUSIONS
  Both exposure to asbestos and deficiency of GSTM1 genotype were related to lipid peroxidation in workers, but the role of the former may be more important than that of the latter.
authors.affiliation: Department of Occupational and Environmental Health, School of Public Health, Peking University, Beijing 100083, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yan
authors.forename: Qien
authors.initials: Q
authors.lastname: Wang
authors.forename: Yanling
authors.initials: Y
authors.lastname: Yin
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Zhao
authors.forename: Gangzhu
authors.initials: G
authors.lastname: Liu
authors.forename: Fei
authors.initials: F
authors.lastname: Yu
authors.forename: Yuejin
authors.initials: Y
authors.lastname: Wang
authors.forename: Shijie
authors.initials: S
authors.lastname: Liu
mesh_terms: D001194:Asbestos / Q000009:adverse effects*; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000032:analysis; D016273:Occupational Exposure
chemical_list: D001194:Asbestos; D005982:Glutathione Transferase; D008315:Malondialdehyde