Clonal cytotoxic T cells in myeloma.
Multiple myeloma (MM) is a malignant disease characterized by accumulation of morphologically recognizable plasma cells producing immunoglobulin (Ig) in the bone marrow. The occurrence of clonal T cells in MM, as defined by the presence of rearrangements in the T-cell receptor (TCR)-beta chains detected on Southern blotting, is associated with an improved prognosis. This review aims to describe the various ways in which we have demonstrated the presence of such T cell clones, and to describe the phenotype of these cells. Finally, the specificities of these clinically important CD8+ T cell populations will be discussed in the context of immunotherapy.
Sze
Daniel M Y
DM
Institute of Haematology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia. d.sze@centenary.usyd.edu.au
Brown
Ross D
RD
Yuen
Edna
E
Gibson
John
J
Ho
Joy
J
Raitakari
Maria
M
Basten
Antony
A
Joshua
Douglas E
DE
Fazekas de St Groth
Barbara
B
D001853:Bone Marrow / Q000473:pathology; D002999:Clone Cells / Q000276:immunology / Q000473:pathology; D005544:Forecasting; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D010641:Phenotype; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000473:pathology
D011948:Receptors, Antigen, T-Cell