title: Null mutation of HvrA compensates for loss of an essential relA/spoT-like gene in Rhodobacter capsulatus.
abstract: We report that a single relA/spoT-like gene exists on the Rhodobacter capsulatus chromosome, and its mutational loss is lethal. This gene could be mutated only under a mutational background of a null mutation in the nucleoid protein HvrA. This result suggests that there may be a direct link between HvrA-regulated promoters and the ppGpp-related stringent response.
authors.affiliation: Laboratory for Photobiology, RIKEN Photodynamics Research Center, Sendai 980-0845, Japan. smasuda@postman.riken.go.jp
authors.forename: Shinji
authors.initials: S
authors.lastname: Masuda
authors.forename: Carl E
authors.initials: CE
authors.lastname: Bauer
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics*; D003470:Culture Media; D015964:Gene Expression Regulation, Bacterial; D006159:Guanosine Tetraphosphate / Q000378:metabolism; D008969:Molecular Sequence Data; D009154:Mutation; D016328:NF-kappa B / Q000737:chemistry / Q000235:genetics*; D010860:Pigments, Biological / Q000378:metabolism; D011755:Pyrophosphatases / Q000737:chemistry / Q000235:genetics*; D016354:Rhodobacter capsulatus / Q000235:genetics / Q000254:growth & development / Q000502:physiology; D015534:Trans-Activators / Q000235:genetics*; D051996:Transcription Factor RelA
chemical_list: D001426:Bacterial Proteins; D003470:Culture Media; C090405:HvrA protein, Rhodobacter capsulatus; D016328:NF-kappa B; D010860:Pigments, Biological; D015534:Trans-Activators; D051996:Transcription Factor RelA; D006159:Guanosine Tetraphosphate; C027627:guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase; D011755:Pyrophosphatases