title: Patient-controlled sedation with propofol in minor oral surgery.
abstract: OBJECTIVE
  We sought to evaluate the benefits of patient-controlled sedation with propofol for minor oral surgery.
  
  
  METHODS
  After instructions were given on how to use the technique, 28 male and 24 female patients sedated themselves during minor oral surgery with titrating 18-mg bolus doses of propofol with a lockout period of 1 minute.
  
  
  RESULTS
  Surgery lasted from 5 to 29 minutes; 28 patients were moderately and 17 were deeply sedated. Seven patients were oversedated. All of those who were oversedated responded to commands within 1 minute of being unresponsive and continued to obtain increments of propofol. Vital signs were stable in all patients even during oversedation. Eighteen patients were talkative, and 17 complained of pain along the vein. Operating conditions were good in 38, fair in 12, and poor in 2. The majority, 48 patients, were relaxed, and 47 were willing to undergo the sedation technique again. Ten had total, 22 had partial, and 20 had no amnesia.
  
  
  CONCLUSIONS
  Relaxed patients, good operating conditions, and quick recovery of oversedated patients without unstable vital signs provide evidence that propofol has favorable pharmacokinetic and pharmacodynamic properties for patient-controlled sedation. This study also highlights the importance of close monitoring of patients during patient-controlled sedation.
authors.affiliation: Department of Anaesthesiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, People's Republic of China. rodrigo@hkusua.hku.hk
authors.forename: Chandra
authors.initials: C
authors.lastname: Rodrigo
authors.forename: Michael G
authors.initials: MG
authors.lastname: Irwin
authors.forename: Bill S W
authors.initials: BS
authors.lastname: Yan
authors.forename: Man Hei
authors.initials: MH
authors.lastname: Wong
mesh_terms: D000293:Adolescent; D000328:Adult; D016058:Analgesia, Patient-Controlled; D000762:Anesthesia Recovery Period; D000766:Anesthesia, Dental / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D016292:Procedural Sedation / Q000379:methods; D062787:Drug Overdose; D005260:Female; D006801:Humans; D008297:Male; D019647:Oral Surgical Procedures / Q000379:methods*; D015742:Propofol / Q000008:administration & dosage*
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol