title: NaHCO(3) does not affect arterial O(2) tension but attenuates desaturation of hemoglobin in maximally exercising Thoroughbreds.
abstract: The objective of the present study was to examine the effects of preexercise NaHCO(3) administration to induce metabolic alkalosis on the arterial oxygenation in racehorses performing maximal exercise. Two sets of experiments, intravenous physiological saline and NaHCO(3) (250 mg/kg i.v.), were carried out on 13 healthy, sound Thoroughbred horses in random order, 7 days apart. Blood-gas variables were examined at rest and during incremental exercise, leading to 120 s of galloping at 14 m/s on a 3.5% uphill grade, which elicited maximal heart rate and induced pulmonary hemorrhage in all horses in both treatments. NaHCO(3) administration caused alkalosis and hemodilution in standing horses, but arterial O(2) tension and hemoglobin-O(2) saturation were unaffected. Thus NaHCO(3) administration caused a reduction in arterial O(2) content at rest, although the arterial-to-mixed venous blood O(2) content gradient was unaffected. During maximal exercise in both treatments, arterial hypoxemia, desaturation, hypercapnia, acidosis, hyperthermia, and hemoconcentration developed. Although the extent of exercise-induced arterial hypoxemia was similar, there was an attenuation of the desaturation of arterial hemoglobin in the NaHCO(3)-treated horses, which had higher arterial pH. Despite these observations, the arterial blood O(2) content of exercising horses was less in the NaHCO(3) experiments because of the hemodilution, and an attenuation of the exercise-induced expansion of the arterial-to-mixed venous blood O(2) content gradient was observed. It was concluded that preexercise NaHCO(3) administration does not affect the development and/or severity of arterial hypoxemia in Thoroughbreds performing short-term, high-intensity exercise.
authors.affiliation: Departments of Veterinary Biosciences and Clinical Medicine, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA. mmanohar@uiuc.edu
authors.forename: Murli
authors.initials: M
authors.lastname: Manohar
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Goetz
authors.forename: Aslam S
authors.initials: AS
authors.lastname: Hassan
mesh_terms: D000818:Animals; D001158:Arteries; D001798:Blood Proteins / Q000378:metabolism; D001831:Body Temperature; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006736:Horses; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009994:Osmolar Concentration; D010100:Oxygen / Q000097:blood*; D010108:Oxyhemoglobins / Q000378:metabolism; D010807:Physical Endurance; D017693:Sodium Bicarbonate / Q000494:pharmacology*; D013997:Time Factors; D014680:Veins
chemical_list: D001798:Blood Proteins; D006454:Hemoglobins; D010108:Oxyhemoglobins; D017693:Sodium Bicarbonate; D010100:Oxygen