Synthesis and pharmacological assessment of derivatives of isoxazolo[4,5-d]pyrimidine.
A series of new 5-alkyl and 5-arylisoxazolo[4,5-d]pyrimidinones (5a-g, 6-8) were prepared from 4-amino-3-oxo-isoxazolidine-5-carboxylic acid amide. Some of the aryl derivatives of isoxazolo[4,5-d]pyrimidine were tested pharmacologically in comparison with Diazepam. Compounds 5b-d and 7 demonstrated interesting anxiolytic activity.
Wagner
Edwin
E
Department of Drugs Technology, Wroclaw Medical University, Nankier Sq. 1,50-140, Wroclaw, Poland. wagner@bf.uni.wroc.pl
Becan
Lilianna
L
Nowakowska
Elzbieta
E
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D014151:Anti-Anxiety Agents; D007555:Isoxazoles; D011743:Pyrimidines