[Parameters of acquired immunity and cation proteins of neutrophilic granulocytes in pulmonary tuberculosis].
Clinical and immunological studies of 61 patients with pulmonary tuberculosis have indicated that the status of acquired and congenital (natural) immunity assessed by the intra- and extracellular levels of cation proteins of neutrophilic granulocytes is different in different clinical forms of pulmonary tuberculosis. The found correlations suggest that there is a relationship between the factors of acquired and congenital immunity and that cytokines are involved in the regulation of specific inflammation. More active degranulation of azurophilic granules of neutrophils occurs due to myeloperoxidase. Unlike other forms, fibrocavernous pulmonary tuberculosis shows a negative correlation between intra- and extracellular content of cation proteins. The findings make it possible to use the parameters of congenital immunity for more detailed characterization of an immune response in tuberculosis, which may be essential in developing new pathogenetic therapy regimens.
Sakharova
I Ia
IIa
Ariel'
B M
BM
Skvortsova
L A
LA
Knoring
B E
BE
Aleshina
G M
GM
Kokriakov
V N
VN
D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D015549:Basophil Degranulation Test; D002412:Cations; D016207:Cytokines / Q000378:metabolism / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology*; D009195:Peroxidase / Q000378:metabolism / Q000502:physiology; D014397:Tuberculosis, Pulmonary / Q000201:enzymology / Q000276:immunology* / Q000628:therapy
D000907:Antibodies, Bacterial; D002412:Cations; D016207:Cytokines; D009195:Peroxidase