Diversity of the muscarinic and nicotinic responses of subfornical organ neurons in rat slice preparations.
Recently we found that subfornical organ (SFO) neurons were activated through nicotinic receptors as well as muscarinc. In this study, the preferential responses of single SFO neurons to both muscarine and nicotine were examined by using rat slice preparations, and current and voltage clamp recordings. When the amplitudes of the depolarizations and inward currents by muscarine and nicotine in single SFO neurons were compared, some neurons showed a higher sensitivity to muscarine than to nicotine while others showed vice versa. These data indicate that acetylcholine activates SFO neurons preferentially through either muscarinic or nicotinic receptors and suggest a diversity of cholinergic responses in the SFO.
Inenaga
Kiyotoshi
K
Department of Physiology, Kyushu Dental College, 2-6-1, Manazuru, Kokurakitaku, Kitakyushu 803-8580, Japan. ine@kyu-dent.ac.jp
Honda
Eiko
E
Ono
Kentaro
K
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D004326:Drinking / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D009116:Muscarine / Q000494:pharmacology; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009538:Nicotine / Q000494:pharmacology; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000187:drug effects / Q000378:metabolism*; D013356:Subfornical Organ / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000502:physiology
D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D009538:Nicotine; D009116:Muscarine