New biophysical probes for structure-activity analyses of vacuolar-H+ -ATPase enzymes.
New EPR spin labelled and photoactivatable molecules have been designed to probe specifically the vacuolar-H(+)-ATPase.
Dixon
Neil
N
Department of Chemistry, Woodhouse Lane, Leeds, UK LS2 9JT.
Pali
Tibor
T
Ball
Stephen
S
Harrison
Michael A
MA
Marsh
Derek
D
Findlay
John B C
JB
Kee
Terence P
TP
D000475:Alkenes / Q000138:chemical synthesis / Q000494:pharmacology*; D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology*; D007536:Isomerism; D008954:Models, Biological; D008956:Models, Chemical; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis / Q000494:pharmacology*; D013113:Spin Labels; D013329:Structure-Activity Relationship; D013696:Temperature; D025262:Vacuolar Proton-Translocating ATPases / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism; D015003:Yeasts / Q000187:drug effects / Q000201:enzymology
C482268:(2Z,4E)-5-(5,6-dichloro-2-indolyl)-2-methoxy-N-(4-(2,2,6,6- tetramethylpiperidinoxy))-2,4-pentadienamide; D000475:Alkenes; D000577:Amides; D004791:Enzyme Inhibitors; D007211:Indoles; D010880:Piperidines; D013113:Spin Labels; D025262:Vacuolar Proton-Translocating ATPases