Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese: significant linkage to chromosome 6q21-q23 and chromosome 1q21-q24.
This genome-wide search for susceptibility genes to type 2 diabetes/impaired glucose homeostasis (IGH) was performed on a relatively homogeneous Chinese sample with a total number of 257 pedigrees and 385 affected sibpairs. Two regions showed significant linkage to type 2 diabetes/IGH in the Chinese. The region showing linkage to type 2 diabetes/IGH from the entire sample group analysis was located on chromosome 6q21-q23 (128.93 cM, 1-LOD [logarithm of odds] support interval between 124 and 142 cM, according to the Marshfield genetic map), with a maximum likelihood score of 6.23, a nonparametric linkage (all) score of 4.48, and empirical P value <0.001. With a subanalysis based on 101 affected sibpairs with age at diagnosis of type 2 diabetes/IGH <40 years, we detected significant evidence for linkage to chromosome 1q21-q24 (192.1 cM, 1-LOD support interval between 182 and 197 cM), with a maximum likelihood score of 8.91, a nonparametric linkage (all) score of 5.70, and empirical P value <0.001. No interaction was observed between these two regions. Our independent replication of the region on chromosome 1q that has been shown to be linked significantly to type 2 diabetes/IGH in Chinese supports the notion that gene(s) in this region may be universally important in the development of human type 2 diabetes.
Xiang
Kunsan
K
Shanghai Diabetes Institute, and Department of Endocrinology and Metabolism, Shanghai Jiaotong University No. 6 People's Hospital, Shanghai, China. sphxiang@public.sta.net.cn
Wang
Yanqing
Y
Zheng
Taishan
T
Jia
Weiping
W
Li
Jie
J
Chen
Lei
L
Shen
Kunxue
K
Wu
Songhua
S
Lin
Xin
X
Zhang
Guodong
G
Wang
Congrong
C
Wang
Suijun
S
Lu
Huijuan
H
Fang
Qichen
Q
Shi
Yi
Y
Zhang
Rong
R
Xu
Jing
J
Weng
Qin
Q
D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D002681:China; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002896:Chromosomes, Human, Pair 6; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015894:Genome, Human; D018149:Glucose Intolerance / Q000235:genetics*; D006706:Homeostasis; D006801:Humans; D008297:Male
D001786:Blood Glucose