title: Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure.
abstract: COENZYME Q10 IN PHYSICAL EXERCISE. We identified eleven studies in which CoQ10 was tested for an effect on exercise capacity, six showed a modest improvement in exercise capacity with CoQ10 supplementation but five showed no effect. CoQ10 IN HYPERTENSION. We identified eight published trials of CoQ10 in hypertension. Altogether in the eight studies the mean decrease in systolic blood pressure was 16 mm Hg and in diastolic blood pressure, 10 mm Hg. Being devoid of significant side effects CoQ10 may have a role as an adjunct or alternative to conventional agents in the treatment of hypertension. CoQ10 IN HEART FAILURE. We performed a randomised double blind placebo-controlled pilot trial of CoQ10 therapy in 35 patients with heart failure. Over 3 months, in the CoQ10 patients but not in the placebo patients there were significant improvements in symptom class and a trend towards improvements in exercise time. META-ANALYSIS OF RANDOMISED TRIALS OF COENZYME Q10 IN HEART FAILURE. In nine randomised trials of CoQ10 in heart failure published up to 2003 there were non-significant trends towards increased ejection fraction and reduced mortality. There were insufficient numbers of patients for meaningful results. To make more definitive conclusions regarding the effect of CoQ10 in cardiac failure we recommend a prospective, randomised trial with 200-300 patients per study group. Further trials of CoQ10 in physical exercise and in hypertension are recommended.
authors.affiliation: Cardiac Surgical Research Unit, Alfred Hospital and Baker Institute, Melbourne, Victoria, Australia. f.rosenfeldt@alfred.org.au
authors.forename: Franklin
authors.initials: F
authors.lastname: Rosenfeldt
authors.forename: Deborah
authors.initials: D
authors.lastname: Hilton
authors.forename: Salvatore
authors.initials: S
authors.lastname: Pepe
authors.forename: Henry
authors.initials: H
authors.lastname: Krum
mesh_terms: D002303:Cardiac Output, Low / Q000188:drug therapy*; D003067:Coenzymes; D015444:Exercise / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D016239:MEDLINE; D015201:Meta-Analysis as Topic; D018482:Muscle, Skeletal / Q000187:drug effects / Q000502:physiology; D010101:Oxygen Consumption / Q000187:drug effects; D016032:Randomized Controlled Trials as Topic; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use*
chemical_list: D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10