Short report: requirement of b cells for delayed type hypersensitivity-like pathology after secondary infection with Leishmania major in resistant C57BL/6 mice.
B cell-deficient C57B1/6 (microMT) mice were resistant to Leishmania major after both primary and secondary parasite challenge. However, unlike in wild-type mice, secondary infection in microMT mice was not accompanied by a marked delayed type hypersensitivity-like response, and interferon-gamma (IFN-gamma) levels were approximately half of those in wild-type mice. These results suggest that B cells are involved in IFN-gamma production and the pathology of secondary infection.
DeKrey
Gregory K
GK
Department of Biological Sciences, University of Northern Colorado, College of Arts and Sciences, Greeley, Colorado 80639, USA. gregory.dekrey@unco.edu
Jones
Jeremy J
JJ
Mbow
M Lamine
ML
Brodskyn
Claudia I
CI
Titus
Richard G
RG
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D006968:Hypersensitivity, Delayed / Q000473:pathology*; D007371:Interferon-gamma / Q000096:biosynthesis; D018320:Leishmania major / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout
D007371:Interferon-gamma