title: Pharmacokinetics of amprenavir given once or twice a day when combined with atazanavir in heavily pre-treated HIV-positive patients.
abstract: We studied the pharmacokinetics of amprenavir at doses of 600 mg twice a day or 1200 mg once a day, when co-administered to HIV-positive patients with 400 mg a day of atazanavir without a ritonavir booster. Our preliminary results suggest that amprenavir and atazanavir could be coadministered and that amprenavir could be boosted by atazanavir without the need for ritonavir pharmaco-enhancement.
authors.affiliation: Department of Infectious Diseases, Vita/Salute University, San Raffaele Scientific Institute, Milan, Italy.
authors.forename: Monica
authors.initials: M
authors.lastname: Guffanti
authors.forename: Cleta Raffaella
authors.initials: CR
authors.lastname: De Pascalis
authors.forename: E
authors.initials: E
authors.lastname: Seminari
authors.forename: Giuliana
authors.initials: G
authors.lastname: Fusetti
authors.forename: Nicola
authors.initials: N
authors.lastname: Gianotti
authors.forename: Dante
authors.initials: D
authors.lastname: Bassetti
authors.forename: Andrea
authors.initials: A
authors.lastname: Galli
authors.forename: Antonella
authors.initials: A
authors.lastname: Castagna
authors.forename: Adriano
authors.initials: A
authors.lastname: Lazzarin
mesh_terms: D000328:Adult; D000069446:Atazanavir Sulfate; D002219:Carbamates; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D005663:Furans; D017320:HIV Protease Inhibitors / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D006679:HIV Seropositivity / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000008:administration & dosage*; D010865:Pilot Projects; D011725:Pyridines / Q000008:administration & dosage*; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D013449:Sulfonamides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D016896:Treatment Outcome
chemical_list: D002219:Carbamates; D005663:Furans; D017320:HIV Protease Inhibitors; D009842:Oligopeptides; D011725:Pyridines; D018894:Reverse Transcriptase Inhibitors; D013449:Sulfonamides; D000069446:Atazanavir Sulfate; C095108:amprenavir