title: Difference in mGluR5 interaction between positive allosteric modulators from two structural classes.
authors.affiliation: Department of Neuroscience-WP, Merck Research Laboratories, West Point, Pennsylvania and Rahway, New Jersey. david_williams1@merck.com
authors.forename: David L
authors.initials: DL
authors.lastname: Williams
authors.forename: Julie A
authors.initials: JA
authors.lastname: O'Brien
authors.forename: Wei
authors.initials: W
authors.lastname: Lemaire
authors.forename: Tsing-Bau
authors.initials: TB
authors.lastname: Chen
authors.forename: Raymond S L
authors.initials: RS
authors.lastname: Chang
authors.forename: Marlene A
authors.initials: MA
authors.lastname: Jacobson
authors.forename: Sookhee N
authors.initials: SN
authors.lastname: Ha
authors.forename: David D
authors.initials: DD
authors.lastname: Wisnoski
authors.forename: Craig W
authors.initials: CW
authors.lastname: Lindsley
authors.forename: Cyrille
authors.initials: C
authors.lastname: Sur
authors.forename: Mark E
authors.initials: ME
authors.lastname: Duggan
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Pettibone
authors.forename: P Jeffrey
authors.initials: PJ
authors.lastname: Conn
mesh_terms: D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D001665:Binding Sites; D016466:CHO Cells; D006224:Cricetinae; D018690:Excitatory Amino Acid Agonists / Q000737:chemistry / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000737:chemistry / Q000494:pharmacology*; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D006834:Hydrazines / Q000494:pharmacology; D010797:Phthalimides / Q000494:pharmacology; D051381:Rats; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000737:chemistry / Q000187:drug effects*; D012118:Resorcinols / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: C481447:3,3'-difluorobenzaldazine; D001549:Benzamides; D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; C578935:GRM5 protein, human; C578937:Grm5 protein, rat; D006834:Hydrazines; C481448:N-(4-chloro-2-((1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl)phenyl)-2-hydroxybenzamide; D010797:Phthalimides; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; D012118:Resorcinols; C079215:3,5-dihydroxyphenylglycine; D005998:Glycine