Coenzyme Q10-containing composition (Immugen) protects against occupational and environmental stress in workers of the gas and oil industry.
The manual workers of the gas-and-oil extraction industry are exposed to hostile environmental and occupational conditions, resulting in elevated mortality and disability, due to chronic neurological and cardiovascular diseases. We evaluated the degree of oxidative stress, often associated with these pathological features, in the blood of manual and office employees of Russian Siberian extraction plants, and their psycho-physiological conditions. Results showed increased levels of spontaneous (p < 0.05) and PMA-activated (p < 0.01) luminol-dependent chemiluminescence (LDCL) in the white blood cells (WBC), and decreased peroxynitrite levels (p < 0.05) in the group of manual workers, and less markedly in the clerks and technicians working on spot, vs. a control group of city clerks. Superoxide release by WBC, and plasma/WBC membrane ubiquinol levels did not display major differences in the three groups. A relevant percentage of manual/office workers of extraction platforms presented impaired cardiovascular and neurological functions. The short term administration of a nutraceutical formulation based on coenzyme10, vitamin E, selenium, methionine and phospholipids led to significant improvement of cardiovascular parameters and psycho-emotional status, consistent with the normalization of LDCL and peroxynitrite production by WBC, with a good compliance to treatment confirmed by the increased blood levels of ubiquinol.
Korkina
Ludmila
L
Department of Molecular Biology, Russian State Medical University, Moscow, Russia. korkin@aha.ru
Deeva
Irina
I
Ibragimova
Galina
G
Shakula
Alexander
A
Luci
Antonio
A
De Luca
Chiara
C
D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D003067:Coenzymes; D019587:Dietary Supplements; D004644:Emotions; D004777:Environment; D005260:Female; D006801:Humans; D007219:Industrial Oils; D007962:Leukocytes / Q000502:physiology; D008163:Luminescent Measurements; D008165:Luminol / Q000494:pharmacology; D008297:Male; D008715:Methionine / Q000008:administration & dosage; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology / Q000517:prevention & control; D016273:Occupational Exposure; D018384:Oxidative Stress; D030421:Peroxynitrous Acid / Q000097:blood; D010578:Petroleum; D010743:Phospholipids / Q000008:administration & dosage; D012426:Russia; D012643:Selenium / Q000008:administration & dosage; D012800:Siberia; D013481:Superoxides / Q000097:blood; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014451:Ubiquinone / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000097:blood; D014810:Vitamin E / Q000008:administration & dosage
D003067:Coenzymes; D010578:Petroleum; D010743:Phospholipids; D013481:Superoxides; D014451:Ubiquinone; D014810:Vitamin E; D030421:Peroxynitrous Acid; D008165:Luminol; D008715:Methionine; C024989:coenzyme Q10; D012643:Selenium; C003741:ubiquinol; D013755:Tetradecanoylphorbol Acetate