title: Characterization of dendritic cells in humans with type 1 diabetes.
abstract: The characterization of dendritic cells (DCs) in diabetes has primarily examined in vitro-generated DCs. In this study, we have compared the composition and phenotype of naturally occurring DCs within the peripheral blood of subjects with type 1 diabetes, latent-onset autoimmune diabetes in adults, and nondiabetic controls. We find that circulatory DC subsets exist in normal frequencies and phenotypic states in diabetic patients. In vivo, DCs were located around the pancreatic islets in type 1 diabetic patients, but were absent in pancreatic tissue of normal controls. These findings provide new insight toward understanding the pathological role of DCs in type 1 diabetes.
authors.affiliation: John P. Robarts Research Institute, London, Ontario N6A 5C1, Canada. ksummers@uwo.ca
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Summers
authors.forename: Margaret T
authors.initials: MT
authors.lastname: Behme
authors.forename: Jeffery L
authors.initials: JL
authors.lastname: Mahon
authors.forename: Bhagirath
authors.initials: B
authors.lastname: Singh
mesh_terms: D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D003713:Dendritic Cells / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D010179:Pancreas / Q000276:immunology / Q000473:pathology; D010641:Phenotype