title: EICO (Expression-based Imprint Candidate Organizer): finding disease-related imprinted genes.
abstract: We have developed an integrated database that is specialized for the study of imprinted disease genes. The database contains novel candidate imprinted genes identified by the RIKEN full-length mouse cDNA microarray study, information on validated single nucleotide polymorphisms (SNPs) to confirm imprinting using reciprocal mouse crosses and the predicted physical position of imprinting-related disease loci in the mouse and human genomes. It has two user-friendly search interfaces: the SNP-central view (MuSCAT: MoUse SNP CATalog) and the candidate gene-central view (CITE: Candidate Imprinted Transcripts by Expression). The database, EICO (Expression-based Imprint Candidate Organizer), can be accessed via the World Wide Web (http://fantom2.gsc.riken.jp/EICODB/) and the DAS client software. These data and interfaces facilitate understanding of the mechanism of imprinting in mammalian inherited traits.
authors.affiliation: Division of Genomic Information Resource Exploration, Science of Biological Supramolecular Systems, Yokohama City University, Graduate School of Integrated Science, Yokohama, Kanagawa 230-0045, Japan.
authors.forename: Itoshi
authors.initials: I
authors.lastname: Nikaido
authors.forename: Chika
authors.initials: C
authors.lastname: Saito
authors.forename: Akiko
authors.initials: A
authors.lastname: Wakamoto
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tomaru
authors.forename: Takahiro
authors.initials: T
authors.lastname: Arakawa
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Hayashizaki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Okazaki
mesh_terms: D000818:Animals; D018076:DNA, Complementary / Q000235:genetics; D030541:Databases, Genetic; D004194:Disease; D005826:Genetics, Medical; D016678:Genome; D018392:Genomic Imprinting / Q000235:genetics*; D023281:Genomics; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012984:Software; D014584:User-Computer Interface
chemical_list: D018076:DNA, Complementary