Vitamin C and cancer chemoprevention: reappraisal.
Several studies have reported that even a moderate daily dose of supplementary vitamin C (200 mg) induces the formation of genotoxins from lipid hydroperoxides, thereby resulting in DNA damage and initiation of carcinogenesis. However, other reports questioned the experimental designs used and suggested that the chemopreventive effects of vitamin C may be linked to the inhibition of tumor promotion as well as to the blocking of tumor initiation. In this article, we discuss issues of contention and some controversies related to the potential chemopreventive effects of vitamin C in carcinogenesis.
Lee
Ki Won
KW
Department of Food Science and Technology, School of Agricultural Biotechnology, Seoul National University, Seoul, South Korea.
Lee
Hyong Joo
HJ
Surh
Young-Joon
YJ
Lee
Chang Yong
CY
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D016588:Anticarcinogenic Agents / Q000008:administration & dosage*; D000975:Antioxidants / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D004249:DNA Damage; D019587:Dietary Supplements; D005638:Fruit; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control*; D010084:Oxidation-Reduction; D014481:United States / Q000453:epidemiology; D014675:Vegetables
D000893:Anti-Inflammatory Agents; D016588:Anticarcinogenic Agents; D000975:Antioxidants; D001205:Ascorbic Acid