Schistosomiasis does not contribute to death or recurrence of nontyphoid Salmonella bacteremia in human immunodeficiency virus-infected Malawian adults.
Nontyphoid Salmonella (NTS) bacteremia has a very high mortality and recurrence rate among human immunodeficiency virus (HIV)-infected Malawian adults. Concurrent schistosomal infection might cause persistence of NTS infection and poor response to antibiotic therapy. Therefore, we tested serum samples for Schistosoma-specific circulating anodic antigen to diagnose coinfection with schistosomiasis among consecutive HIV-positive adults with NTS bacteremia. The results suggest that active schistosomiasis is not associated with adverse outcome of NTS bacteremia in this population, in contrast to other groups.
Gordon
Melita A
MA
Wellcome Trust Laboratories, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Chichiri, Malawi. mgordon@mlw.medcol.mw
Zijlstra
Eduard E
EE
Naus
Cynthia W A
CW
Visser
Leo G
LG
Molyneux
Malcolm E
ME
van Lieshout
Lisette
L
D000328:Adult; D000818:Animals; D000947:Antigens, Helminth / Q000097:blood; D016470:Bacteremia / Q000150:complications* / Q000401:mortality; D005260:Female; D006023:Glycoproteins / Q000097:blood; D006678:HIV; D015658:HIV Infections / Q000150:complications* / Q000401:mortality; D015801:Helminth Proteins / Q000097:blood; D006801:Humans; D008297:Male; D012480:Salmonella Infections / Q000150:complications* / Q000401:mortality; D012552:Schistosomiasis / Q000150:complications* / Q000401:mortality; D016896:Treatment Outcome
D000947:Antigens, Helminth; D006023:Glycoproteins; D015801:Helminth Proteins; C090907:circulating anodic antigen, Schistosoma mansoni