title: Granulocyte colony-stimulating factor-producing cutaneous angiosarcoma with leukaemoid reaction arising on a burn scar.
abstract: We report a 46-year-old man with a giant tumour in a burn scar on his buttock. Pathological examination revealed that the dermis was filled with anastomosing vascular channels and round- or spindle-type atypical cells, which were compatible with the diagnosis of cutaneous angiosarcoma. Based on prominent leucocytosis (up to 113 000 microL-1), we measured serum granulocyte colony-stimulating factor (G-CSF). The highly elevated serum G-CSF of 303 ng L-1 (normal, 6.1-21.5 ng L-1) and positive immunohistochemical staining of the tumour tissue for G-CSF indicated that G-CSF was produced by the cutaneous angiosarcoma. To our knowledge, this is the first reported case of G-CSF-producing cutaneous angiosarcoma.
authors.affiliation: Department of Dermatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan. nararing@koto.kpu-m.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Nara
authors.forename: A
authors.initials: A
authors.lastname: Hayakawa
authors.forename: A
authors.initials: A
authors.lastname: Ikeuchi
authors.forename: N
authors.initials: N
authors.lastname: Katoh
authors.forename: S
authors.initials: S
authors.lastname: Kishimoto
mesh_terms: D000328:Adult; D002056:Burns / Q000150:complications; D002081:Buttocks; D002921:Cicatrix / Q000150:complications; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006394:Hemangiosarcoma / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007955:Leukemoid Reaction / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology
chemical_list: D016179:Granulocyte Colony-Stimulating Factor