title: Analysis of fibril formation of amyloid-beta-protein by stretched exponential function.
abstract: Kinetic behavior of aggregation of amyloid-beta-protein (Abeta) is represented by a stretched exponential function, F=A[1-exp(-Bt(n))]. Differences in temperature-dependence of A, B and n are studied for Abeta 1-40 and Abeta 1-42. As the temperature is lowered, parameter A is increased, parameter B is decreased and parameter n is increased in Abeta 1-40, while these parameters are less sensitive to temperature in a more hydrophobic protein Abeta 1-42. ln B is a linear function of n, which is shown by ln B = -6.34n + 3.69.
authors.affiliation: Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan.
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Shinozaki
authors.forename: Takeo
authors.initials: T
authors.lastname: Konakahara
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Okuno
authors.forename: Masato
authors.initials: M
authors.lastname: Kodaka
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry*; D001923:Brain Chemistry; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D012997:Solvents; D013696:Temperature
chemical_list: D016229:Amyloid beta-Peptides; D012997:Solvents