Growth of girls who later develop coronary heart disease.
OBJECTIVE
To determine the path of growth of girls who later develop coronary heart disease.


METHODS
Follow up study of girls whose body size at birth, during infancy, and childhood up to age 12 years was recorded.


METHODS
Helsinki, Finland.


METHODS
4130 girls who were born between 1934 and 1944, attended child welfare clinics in Helsinki, and were still resident in Finland in 1971.


METHODS
Hospital admission or death from coronary heart disease.


RESULTS
In comparison with boys in the same cohort who later developed coronary heart disease the 87 girls were short at birth, rather than thin, had compensatory growth in height during infancy, became thin, and thereafter had a rapid increase in weight and body mass index. In a combined analysis the hazard ratios for coronary heart disease were 1.17 (95% confidence interval (CI) 1.03 to 1.32, p = 0.02) for each 1 cm decrease in length at birth, 1.52 (95% CI 1.23 to 1.89, p < 0.001) for each standard deviation score increase in body mass index after age 3 years, and 1.63 (95% CI 1.09 to 2.42, p = 0.02) for each decrease in level of education.


CONCLUSIONS
Though broadly similar, the paths of growth associated with the later development of coronary heart disease differ in girls and boys. This may be because girls are less vulnerable to undernutrition in utero and are better able to sustain postnatal growth in an adverse environment.
Forsén
T
T
Southampton General Hospital, Tremona Road, Southampton, UK.
Osmond
C
C
Eriksson
J G
JG
Barker
D J P
DJ
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003327:Coronary Disease / Q000453:epidemiology* / Q000503:physiopathology; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D006128:Growth / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016016:Proportional Hazards Models; D012307:Risk Factors; D012923:Social Class; D015430:Weight Gain