Development of diabetes mellitus post-renal transplantation is associated with poor short-term clinical outcomes.
BACKGROUND
Although posttransplant diabetes mellitus (PTDM) is associated with poor long-term outcomes short-term outcomes are not well studied in renal transplant recipients (RTRs).


METHODS
RTRs between January 1999 and December 2000 (n = 181) stratified according to the occurrence of diabetes mellitus (DM), namely, non-DM (n = 72), previous DM (n = 88), and PTDM (n = 21) were compared for infections, hospital readmissions, and graft rejections during the first 6 months posttransplantation.


RESULTS
PTDM showed patients affected by a significantly higher rate of infections (57.1% vs 29.2%) and recurrent infections (28.5% vs 11.1%) compared to non-DM and a trend toward an increase compared to previous DM. PTDM patients had a significantly higher incidence of multiple readmissions compared to both previous DM (52.4% vs 20.5%) and non-DM (52.4% vs 23.6%). Subjects with PTDM showed a significantly higher occurrence of rejection (28.6% vs 9.1%) and recurrent rejection (14.3% vs 2.3%) than previous DM and a greater trend compared to non-DM.


CONCLUSIONS
PTDM is associated with poorer short-term outcomes than either non-DM or previous DM.
Saleem
T F M
TF
Milton S. Hershey Medical Center, Penn State College of Medicine, 400 University Drive, Hershey, PA 17033, USA
Cunningham
K E
KE
Hollenbeak
C S
CS
Alfrey
E J
EJ
Gabbay
R A
RA
D003920:Diabetes Mellitus / Q000453:epidemiology*; D006084:Graft Rejection / Q000453:epidemiology; D006801:Humans; D007239:Infections / Q000453:epidemiology; D016030:Kidney Transplantation / Q000502:physiology*; D011183:Postoperative Complications / Q000453:epidemiology*; D012189:Retrospective Studies; D013997:Time Factors; D017211:Treatment Failure; D016896:Treatment Outcome