title: Circulating matrix metalloproteinase-1 and -3 in patients with an acute coronary syndrome.
abstract: To elucidate the diagnostic value of serum matrix metalloproteinase (MMP) levels, we measured MMP-1 and MMP-3 by a 1-step sandwich enzyme immunoassay. The transcardiac gradients of both MMPs were greater in patients with unstable angina and acute myocardial infarction than in patients with stable effort angina or control patients. Serum MMP levels appear to be a marker of plaque instability in patients with acute coronary syndrome.
authors.affiliation: Department of Cardiology, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan. inouet@dokkyomed.ac.jp
authors.forename: Teruo
authors.initials: T
authors.lastname: Inoue
authors.forename: Toru
authors.initials: T
authors.lastname: Kato
authors.forename: Kan
authors.initials: K
authors.lastname: Takayanagi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Uchida
authors.forename: Isao
authors.initials: I
authors.lastname: Yaguchi
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Kamishirado
authors.forename: Shigenori
authors.initials: S
authors.lastname: Morooka
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yoshimoto
mesh_terms: D000787:Angina Pectoris / Q000097:blood*; D000789:Angina, Unstable / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D017023:Coronary Angiography; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000097:blood*; D019278:Matrix Metalloproteinase 3 / Q000097:blood*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood
chemical_list: D015415:Biomarkers; D019715:Tissue Inhibitor of Metalloproteinase-1; D019278:Matrix Metalloproteinase 3; D020781:Matrix Metalloproteinase 1