title: [Effect of sildenafil ciltrate on the sexual activities of male rats].
abstract: OBJECTIVE
  To obtain related pharmacodynamic data for the clinical experiment by observing the sexual activities of male rats after using sildenafil ciltrate through stomach irrigation.
  
  
  METHODS
  Forty male Sprague-Dawley rats were distributed into 4 groups with different dosages (control with distilled water, low dosage: 0.08%, medium dosage: 0.24% and high dosage: 0.72%). After the male Sprague-Dawlay rats were mated with their female counterparts in pairs, the latent period of chasing, the frequencies of chasing in 60 minutes, the latent period of intercourse and the frequencies of intercourse in 60 minutes were recorded.
  
  
  RESULTS
  Compared with the control, the frequencies of chasing were significantly increased and the latent periods of chasing were significantly shortened in both high dosage and medium dosage groups after using sildenafil (P < 0.01); The frequencies of intercourse in 60 minutes were significantly increased and the latent periods of intercourse were significantly shortened in all the groups after the use of sildenafil.
  
  
  CONCLUSIONS
  The sexual activities of male rats treated with sildenafil were significantly activated.
authors.affiliation: Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei 430030, China.
authors.forename: Xun-Bin
authors.initials: XB
authors.lastname: Huang
authors.forename: Cheng-Liang
authors.initials: CL
authors.lastname: Xiong
authors.forename: Ji-Yun
authors.initials: JY
authors.lastname: Shen
authors.forename: Jie-Ling
authors.initials: JL
authors.lastname: Zhou
authors.forename: Hui-Zhu
authors.initials: HZ
authors.lastname: Xiao
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011687:Purines; D051381:Rats; D017207:Rats, Sprague-Dawley; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D000068677:Sildenafil Citrate; D013450:Sulfones
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate