Antifungal activity of wogonin.
The antifungal activity of the wogonin isolated from Holmskioldia sanguinea Retz was determined on four different fungal organisms. The pure compound wogonin significantly inhibited the growth of Aspergillus niger, Penicillium frequentance, P. notatum and Botrytis cinerea, in a concentration dependent fashion, when tested by turbidity and spore germination methods. The effects produced by the compound were compared with the standard antifungal agent griseofulvin.
Pal
Mahesh
M
Department of Phytochemistry, National Botanical Research Institute, Lucknow 226001, India. drmpal@rediffmail.com
Joshi
Harsha
H
Kapoor
V P
VP
Pushpangadan
P
P
Chaurasia
Leena
L
D000935:Antifungal Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D044950:Flavanones / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006118:Griseofulvin / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves; D029648:Verbenaceae
D000935:Antifungal Agents; D044950:Flavanones; D010936:Plant Extracts; D006118:Griseofulvin; C085514:wogonin