title: Effects of end-inspiratory and end-expiratory pressures on alveolar recruitment and derecruitment in saline-washout-induced lung injury -- a computed tomography study.
abstract: BACKGROUND
  Lung protective ventilation using low end-inspiratory pressures and tidal volumes (VT) has been shown to impair alveolar recruitment and to promote derecruitment in acute lung injury. The aim of the present study was to compare the effects of two different end-inspiratory pressure levels on alveolar recruitment, alveolar derecruitment and potential overdistention at incremental levels of positive end-expiratory pressure.
  
  
  METHODS
  Sixteen adult sheep were randomized to be ventilated with a peak inspiratory pressure of either 35 cm H2O (P35, low VT) or 45 cm H2O (P45, high VT) after saline washout-induced lung injury. Positive end-expiratory pressure (PEEP) was increased in a stepwise manner from zero (ZEEP) to 7, 14 and 21 cm of H2O in hourly intervals. Tidal volume, initially set to 12 ml kg(-1), was reduced according to the pressure limits. Computed tomographic scans during end-expiratory and end-inspiratory hold were performed along with hemodynamic and respiratory measurements at each level of PEEP.
  
  
  RESULTS
  Tidal volumes for the two groups (P35/P45) were: 7.7 +/- 0.9/11.2 +/- 1.3 ml kg(-1) (ZEEP), 7.9 +/- 2.1/11.3 +/- 1.3 ml kg(-1) (PEEP 7 cm H2O), 8.3 +/- 2.5/11.6 +/- 1.4 ml kg(-1) (PEEP 14 cm H2O) and 6.5 +/- 1.7/11.0 +/- 1.6 ml kg(-1) (PEEP 21 cm H2O); P < 0.001 for differences between the two groups. Absolute nonaerated lung volumes during end-expiration and end-inspiration showed no difference between the two groups for given levels of PEEP, while tidal-induced changes in nonaerated lung volume (termed cyclic alveolar instability, CAI) were larger in the P45 group at low levels of PEEP. The decrease in nonaerated lung volume was significant for PEEP 14 and 21 cm H2O in both groups compared with ZEEP (P < 0.005). Over-inflated lung volumes, although small, were significantly higher in the P45 group. Significant respiratory acidosis was noted in the P35 group despite increases in the respiratory rate.
  
  
  CONCLUSIONS
  Limiting peak inspiratory pressure and VT does not impair alveolar recruitment or promote derecruitment when using sufficient levels of PEEP.
authors.affiliation: Department of Anesthesiology and Intensive Care, University Hospital of Mannheim, Faculty of Clinical Medicine, University of Heidelberg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Luecke
authors.forename: H
authors.initials: H
authors.lastname: Roth
authors.forename: A
authors.initials: A
authors.lastname: Joachim
authors.forename: P
authors.initials: P
authors.lastname: Herrmann
authors.forename: B
authors.initials: B
authors.lastname: Deventer
authors.forename: G
authors.initials: G
authors.lastname: Weisser
authors.forename: P
authors.initials: P
authors.lastname: Pelosi
authors.forename: M
authors.initials: M
authors.lastname: Quintel
mesh_terms: D000818:Animals; D018893:Bronchoalveolar Lavage; D002496:Central Venous Pressure / Q000502:physiology; D004548:Elasticity; D006439:Hemodynamics / Q000502:physiology; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000000981:diagnostic imaging* / Q000502:physiology*; D008176:Lung Volume Measurements; D011175:Positive-Pressure Respiration; D011650:Pulmonary Alveoli / Q000502:physiology*; D011651:Pulmonary Artery / Q000502:physiology; D011652:Pulmonary Circulation / Q000502:physiology; D011659:Pulmonary Gas Exchange / Q000502:physiology; D015656:Respiratory Mechanics / Q000502:physiology*; D012756:Sheep; D035441:Thoracic Wall / Q000502:physiology; D013990:Tidal Volume / Q000502:physiology; D014057:Tomography, X-Ray Computed