title: Natural product-like and other biologically active heterocyclic libraries using solid-phase techniques in the post-genomic era.
abstract: High-throughput technologies allow the selection of new biological targets for drug discovery in the post-genomic era. These tools increase the need of new methods to rapidly obtain potent small molecules and natural products to discover new lead structures. In particular, the solid-phase synthesis offers a great potential to obtain large compound sets.
authors.affiliation: Kekulé-Institut für Organische Chemie und Biochemie der Rheinischen, Friedrich-Wilhelms-Universität Bonn, Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Knepper
authors.forename: C
authors.initials: C
authors.lastname: Gil
authors.forename: S
authors.initials: S
authors.lastname: Bräse
mesh_terms: D020650:Combinatorial Chemistry Techniques; D004353:Drug Evaluation, Preclinical / Q000379:methods; D023281:Genomics; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D006571:Heterocyclic Compounds