title: Effects of alcohol hangover on cytokine production in healthy subjects.
abstract: A hangover is the syndrome of physical and mental symptoms that occurs 8 to 16 h after alcohol consumption with a zero level of alcohol. The aim of the current study was to investigate the effects of the alcohol hangover on cytokine production in healthy subjects. The hangover state was defined as 13 h after drinking 1.5 g/kg of alcohol (blood alcohol level=0). A venous blood sample was taken from 20 healthy adult men before consumption of alcohol and during the hangover state. Peripheral blood mononuclear cells were separated and stimulated with phytohemagglutinin. An enzyme-linked immunosorbent assay was used to measure the production of the following cytokines: interleukin (IL)-1beta, IL-4, IL-6, IL-10, IL-12, interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha). We found that the concentrations of IL-10, IL-12, and IFN-gamma were significantly increased during the hangover state compared with the concentrations in normal conditions. These results support the suggestion that the dysregulated cytokine pathway (IL-10, IL-12, and IFN-gamma) is associated with the symptoms of hangovers.
authors.affiliation: Department of Psychiatry, College of Medicine, The Catholic University of Korea, 137-701 Seoul, South Korea. KDJ922@chollian.net
authors.forename: Dai-Jin
authors.initials: DJ
authors.lastname: Kim
authors.forename: Won
authors.initials: W
authors.lastname: Kim
authors.forename: Su-Jung
authors.initials: SJ
authors.lastname: Yoon
authors.forename: Bo-Moon
authors.initials: BM
authors.lastname: Choi
authors.forename: Jung-Soo
authors.initials: JS
authors.lastname: Kim
authors.forename: Hyo Jin
authors.initials: HJ
authors.lastname: Go
authors.forename: Yong-Ku
authors.initials: YK
authors.lastname: Kim
authors.forename: Jaeseung
authors.initials: J
authors.lastname: Jeong
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000097:blood / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis* / Q000097:blood; D005221:Fatigue / Q000097:blood / Q000139:chemically induced / Q000276:immunology; D006261:Headache / Q000097:blood / Q000139:chemically induced / Q000276:immunology; D006801:Humans; D008297:Male; D013577:Syndrome
chemical_list: D016207:Cytokines