title: Association of nonmelanoma skin cancer with second malignancy.
abstract: BACKGROUND
  Heightened risks of second cancers have been reported in patients with nonmelanoma cancer of the skin (NMSC), but this association has not been studied in a large, ethnically diverse, multigeographic population.
  
  
  METHODS
  This cross-sectional study assessed the association of NMSC with another malignancy in the Women's Health Initiative Observational Study, a study that was conducted in 40 communities throughout the U.S. and involved 93,676 postmenopausal women ages 50-79 years. Cancer history, demographics, and previous and current risk exposures were determined by questionnaire at a baseline examination. Logistic regression was used to assess the association (odds ratio) of a history of NMSC with a history of other (non-NMSC) cancers controlling for age and potential confounding factors. Complete cancer data were available in 92,658 women.
  
  
  RESULTS
  In age-adjusted analyses, women with a history of NMSC (n = 7554 women) were 2.30 times as likely to report a history of another cancer, other than NMSC, compared with women who had no history of NMSC (95% confidence interval [95% CI], 2.18-2.44). In a subgroup analysis, black women with NMSC had 7.46 times the odds (95% CI, 3.08-18.0) of reporting a second malignancy compared with black women without NMSC.
  
  
  CONCLUSIONS
  This study provides additional evidence of an association between NMSC and another malignancy in a large, multiethnic population.
authors.affiliation: Department of Medicine, Evanston Northwestern Healthcare, Evanston, Illinois 60201, USA.
authors.forename: Carol A
authors.initials: CA
authors.lastname: Rosenberg
authors.forename: Philip
authors.initials: P
authors.lastname: Greenland
authors.forename: Janardan
authors.initials: J
authors.lastname: Khandekar
authors.forename: Aimee
authors.initials: A
authors.lastname: Loar
authors.forename: Joao
authors.initials: J
authors.lastname: Ascensao
authors.forename: Ana Maria
authors.initials: AM
authors.lastname: Lopez
mesh_terms: D000368:Aged; D044383:Black People; D002280:Basal Cell Carcinoma / Q000150:complications*; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D003430:Cross-Sectional Studies; D005006:Ethnicity; D005260:Female; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology / Q000209:etiology*; D016017:Odds Ratio; D012044:Regression Analysis; D012307:Risk Factors; D012878:Skin Neoplasms / Q000150:complications*