title: [Antiepileptic primidone shortly to be withdrawn from sale: change medication now].
abstract: The antiepileptic drug primidone is to be withdrawn from sale by January 2004. After this date, the drug will still be available for a time, but only on a limited basis. Most primidone users are elderly patients who have been prescribed this drug for many years. Changing to a new drug constitutes a health risk for them. If primidone treatment is discontinued too quickly, withdrawal seizures may appear, some of which may be severe. In patients who have not suffered an epileptic seizure for many years, discontinuing medication may be considered. Whenever continuation of anticonvulsive treatment is desirable, it may probably be a good idea to switch over to some newer antiepileptic drug. If a simple and quick substitution is essential, primidone may be replaced by its main metabolite: phenobarbital. General practitioners and neurologists are strongly advised to alter patients' medication in good time.
authors.affiliation: Stichting Epilepsie Instellingen Nederland, Postbus 21, 2100 AA Heemstede. gjdhaan@sein.nl
authors.forename: G J
authors.initials: GJ
authors.lastname: de Haan
authors.forename: J A
authors.initials: JA
authors.lastname: Carpay
authors.forename: C A
authors.initials: CA
authors.lastname: van Donselaar
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D004335:Drug and Narcotic Control / Q000639:trends; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D010634:Phenobarbital / Q000627:therapeutic use; D011324:Primidone / Q000627:therapeutic use*; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000517:prevention & control
chemical_list: D000927:Anticonvulsants; D011324:Primidone; D010634:Phenobarbital