A critical interaction: leptin and ghrelin.
Continuing research has increased our understanding of regulatory factors involving appetite, food intake, and energy metabolism. There appears to be a complex interaction among insulin, leptin, and ghrelin. A new study explored these interactions and indicates that leptin may regulate ghrelin levels and affect body weight changes.
Williams
Jonathan
J
Loyola University Medical Center, Department of Gastroenterology, 2160 South First Avenue, Maywood, Illinois 60153, USA.
Mobarhan
Sohrab
S
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002149:Energy Intake / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects* / Q000502:physiology; D054439:Ghrelin; D006801:Humans; D007328:Insulin / Q000502:physiology; D020738:Leptin / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D009478:Neuropeptide Y / Q000502:physiology; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism; D036361:Peptide Hormones / Q000378:metabolism / Q000502:physiology*; D051381:Rats
D054439:Ghrelin; D007328:Insulin; D020738:Leptin; D009478:Neuropeptide Y; D036361:Peptide Hormones