[Oncologic pharmacotherapy of elderly patients].
Age is the major risk factor for the development of cancer. Difficulties in medical treatment of elderly patients with cancer may be due to age dependent changes in physiological organ function, which result in pharmacokinetical and pharmacodynamical changes. They also may be due to co-morbidities with the need of pharmacological therapy. The choice of adequate treatment protocols has to consider this age dependent changes in pharmacokinetics and the presence of co-morbidities. Most of the data reporting results of medical oncological treatment in patients with cancer are collected in younger patients. Therefore, the present knowledge concerning medical oncological treatment of elderly patients with cancer is still limited.
Wedding
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Klinik und Poliklinik für Innere Medizin II, Hämatologie, Onkologie, Endokrinologie und Stoffwechselerkrankungen, Friedrich-Schiller-Universität Jena. ulrich.wedding@med.uni-jena.de
Merkel
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U
Farker
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K
Höffken
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K
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001711:Biotransformation / Q000502:physiology; D015577:Geriatric Assessment; D006801:Humans; D009369:Neoplasms / Q000097:blood / Q000188:drug therapy*; D011379:Prognosis; D012307:Risk Factors; D016896:Treatment Outcome
D000970:Antineoplastic Agents