Leucascandrolide A: a second generation formal synthesis.
A convergent, second generation formal synthesis of (+)-Leucascandrolide A (1) has been efficiently achieved by providing a flexible, enantiocontrolled strategy toward the bioactive macrolactone component. Advancements for stereocontrol in asymmetric allylation methodology are discussed. Efforts feature novel results for reductions using the Terashima hydride reagent. [structure: see text]
Williams
David R
DR
Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, IN 47405-7102, USA. williamd@indiana.edu
Patnaik
Samarjit
S
Plummer
Scott V
SV
D000498:Allyl Compounds; D000818:Animals; D007202:Indicators and Reagents; D011161:Porifera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000498:Allyl Compounds; D007202:Indicators and Reagents; D012717:Sesquiterpenes; C408748:leucascandrolide A