title: An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells.
abstract: Lymphoid tissue inducer (LTi) cells are associated with early development of lymph nodes and Peyer's patches. We show here that during fetal life the nuclear hormone receptor RORgamma(t) is expressed exclusively in and is required for the generation of LTi cells. RORgamma(t+) LTi cells provide essential factors, among which lymphotoxin-alpha1beta2 is necessary but not sufficient for activation of the mesenchyma in lymph node and Peyer's patch anlagen. This early LTi cell-mediated activation of lymph node and Peyer's patch mesenchyma forms the necessary platform for the subsequent development of mature lymphoid tissues.
authors.affiliation: Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA. geber@adarc.org
authors.forename: Gérard
authors.initials: G
authors.lastname: Eberl
authors.forename: Shana
authors.initials: S
authors.lastname: Marmon
authors.forename: Mary-Jean
authors.initials: MJ
authors.lastname: Sunshine
authors.forename: Paul D
authors.initials: PD
authors.lastname: Rennert
authors.forename: Yongwon
authors.initials: Y
authors.lastname: Choi
authors.forename: Dan R
authors.initials: DR
authors.lastname: Littman
mesh_terms: D000818:Animals; D005314:Embryonic and Fetal Development / Q000235:genetics / Q000276:immunology / Q000502:physiology; D005260:Female; D005434:Flow Cytometry; D049452:Green Fluorescent Proteins; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000276:immunology; D008164:Luminescent Proteins / Q000235:genetics / Q000378:metabolism; D008221:Lymphoid Tissue / Q000196:embryology* / Q000276:immunology / Q000502:physiology; D008233:Lymphotoxin-alpha / Q000276:immunology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D038081:Organogenesis / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D020395:Receptors, Interleukin-7 / Q000235:genetics / Q000276:immunology; D018168:Receptors, Retinoic Acid / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D011988:Receptors, Thyroid Hormone / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000502:physiology*; D019010:Vascular Cell Adhesion Molecule-1 / Q000235:genetics / Q000276:immunology
chemical_list: D008164:Luminescent Proteins; D008233:Lymphotoxin-alpha; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D020395:Receptors, Interleukin-7; D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone; C539901:Rorc protein, mouse; D019010:Vascular Cell Adhesion Molecule-1; C415350:interleukin-7 receptor, alpha chain; D018799:Intercellular Adhesion Molecule-1; D049452:Green Fluorescent Proteins