A unique collision tumor in breast: invasive ductal carcinoma and mucosa-associated lymphoid tissue lymphoma.
We report an extraordinary case of a collision tumor consisting of invasive ductal carcinoma with adjacent malignant lymphoma presenting as a single mass in the breast. A 79-year-old woman presented with a breast mass. A core biopsy performed at an outside hospital was interpreted as medullary carcinoma. On review of the breast core biopsy, a diagnosis of a synchronous malignant lymphoma and invasive ductal carcinoma was rendered. The patient underwent lumpectomy and axillary dissection. The excised specimen revealed a 2.1-cm, moderately differentiated invasive ductal carcinoma, partially surrounded by malignant lymphoma with areas where both tumors were intermixed. All 27 axillary lymph nodes were extensively involved by lymphoma, and 1 lymph node demonstrated metastatic carcinoma. The morphology and results of immunohistochemistry, flow cytometry, and cytogenetic analysis were consistent with extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue.
Susnik
Barbara
B
Department of Pathology, Medical College of Wisconsin, Milwaukee 53226, USA. bsusnik@mcw.edu
Jordi Rowe
J
J
Redlich
Philip N
PN
Chitambar
Christopher
C
Chang
Chung-Che
CC
Kampalath
Bal
B
D000368:Aged; D001943:Breast Neoplasms / Q000150:complications / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000150:complications / Q000473:pathology*; D005260:Female; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications / Q000473:pathology*