Characterization of the tissue-specific expression of the s100P gene which encodes an EF-hand Ca2+-binding protein.
S100 proteins are a calcium-binding protein family containing two EF-hand domains exclusively expressed in vertebrates and play roles in many cellular activities. Human S100P gene was first cloned as a 439 bp cDNA in placenta and it was found to be associated with human prostate cancer. Here we describe the cloning of the 1297 bp full-length cDNA, and the characterization of the tissue-specific expression of the human S100P gene. It is abundantly expressed in many tissues including placenta by Northern blot and RT-PCR analysis, unlike the expression pattern of other S100 family genes.
Jin
Gang
G
Department of General Surgery, Changhai Hospital, Shanghai 200433, People's Republic of China.
Wang
Shu
S
Hu
Xiangui
X
Jing
Zaiping
Z
Chen
Jinzhong
J
Ying
Kang
K
Xie
Yi
Y
Mao
Yumin
Y
D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003001:Cloning, Molecular; D020832:EF Hand Motifs; D015723:Gene Library; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D014018:Tissue Distribution
D002118:Calcium