[Treatment of hyperplasia endometrium with GNRH agonists].
OBJECTIVE
Untreated hormonal disturbances connected with unbalanced estrogen serum concentrations can influence on pathological proliferation of endometrium. The aim of the study is to assess the effect of GnRH agonists on endometrium in women consulted due to simple hyperplasia endometrium.


METHODS
15 women in the mean age 48.5 +/- 3.5 years with the histopathological diagnosis of simple hyperplasia were treated with trioptorelin during 3 months. After therapy all patients were undergone transvaginal ultrasonography and endometrial biopsy.


RESULTS
Atrophic endometrium were observed in all women after a 3-month therapy. The thickness of endometrium decreased from 10.21 +/- 3.2 mm to 3.94 +/- 1.56 mm.


CONCLUSIONS
The efficacy of the therapy of simple hyperplasia in women with GnRH agonist was 100%.
Radowicki
Stanisław
S
Kliniki Endokrynologii Ginekologicznej AM w Warszawie.
Skórzewska
Katarzyna
K
D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004714:Endometrial Hyperplasia / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology*; D004717:Endometrium / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013997:Time Factors; D016896:Treatment Outcome; D017329:Triptorelin Pamoate / Q000008:administration & dosage*; D014463:Ultrasonography
D018931:Antineoplastic Agents, Hormonal; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone