title: The thrombospondin type 1 repeat (TSR) and neuronal differentiation: roles of SCO-spondin oligopeptides on neuronal cell types and cell lines.
abstract: SCO-spondin is a large glycoprotein secreted by ependymal cells of the subcommissural organ. It shares functional domains called thrombospondin type 1 repeats (TSRs) with a number of developmental proteins expressed in the central nervous system, and involved in axonal pathfinding. Also, SCO-spondin is highly conserved in the chordate phylum and its multiple domain organization is probably a chordate innovation. The putative involvement of SCO-spondin in neuron/glia interaction in the course of development is assessed in various cell culture systems. SCO-spondin interferes with several developmental processes, including neuronal survival, neurite extension, neuronal aggregation, and fasciculation. The TSR motifs, and especially the WSGWSSCSVSCG sequence, are most important in these neuronal responses. Integrins and growth factor receptors may cooperate as integrative signals. We discuss the putative involvement of the subcommissural organ/Reissner's fiber complex in developmental events, as a particular extracellular signaling system.
authors.affiliation: INSERUM UMR 384 et Laboratoire de Biochimie médicale, F-63001 Clermont-Ferrand, France.
authors.forename: Annie
authors.initials: A
authors.lastname: Meiniel
authors.forename: Robert
authors.initials: R
authors.lastname: Meiniel
authors.forename: Nicolas
authors.initials: N
authors.lastname: Gonçalves-Mendes
authors.forename: Isabelle
authors.initials: I
authors.lastname: Creveaux
authors.forename: Robert
authors.initials: R
authors.lastname: Didier
authors.forename: Bernard
authors.initials: B
authors.lastname: Dastugue
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology*; D002460:Cell Line; D019143:Evolution, Molecular; D006801:Humans; D016023:Integrins / Q000378:metabolism; D008969:Molecular Sequence Data; D005810:Multigene Family; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009842:Oligopeptides / Q000378:metabolism*; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D017978:Receptors, Growth Factor / Q000378:metabolism; D013351:Subcommissural Organ / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D019700:Thrombospondin 1 / Q000145:classification / Q000235:genetics* / Q000378:metabolism
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; D016023:Integrins; D009842:Oligopeptides; D017978:Receptors, Growth Factor; C108402:SCO-spondin; D019700:Thrombospondin 1