Self-association of okadaic acid upon complexation with potassium ion.
Okadaic acid (OA) is a toxin responsible for diarrhetic shellfish poisoning and is an extremely useful tool for studying processes that are regulated by phosphorylation, although the exact mechanism of action is still undetermined. We report on a study that proved the existence of OA in an unusual dimeric form when complexed with potassium ion. The proposed structure of this dimer is based on spectroscopic and conformational studies.
Daranas
Antonio H
AH
Instituto Universitario de Bio-Organica Antonio Gonzalez, Universidad de La Laguna, Astrofisico Francisco Sanchez 2, 38206 La Laguna, Tenerife, Spain.
Fernández
José J
JJ
Morales
Ezequiel Q
EQ
Norte
Manuel
M
Gavín
José A
JA
D000818:Animals; D000838:Anions; D004141:Dinoflagellida / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008387:Marine Toxins / Q000737:chemistry* / Q000302:isolation & purification; D008958:Models, Molecular; D019319:Okadaic Acid / Q000737:chemistry* / Q000302:isolation & purification; D011188:Potassium / Q000737:chemistry*; D012996:Solutions
D000838:Anions; D008387:Marine Toxins; D012996:Solutions; D019319:Okadaic Acid; D011188:Potassium