[Excretion of catecholamines in development of the opium and alcohol abstinence syndrome and in post-abstinence period].
Excretion of catecholamines has been studied in patients with opium narcotic and alcoholic dependence in developmental dynamics of the opium and alcoholic abstinence syndrome and in the postabstinence period. It has been revealed that 8-10 h after cessation of the psychoactive substances (the preabstinence period) the level of excretion of adrenaline [A], dioxyphenylalanine [DOPA], dopamine [DA] and, to the greatest extent, of noradrenaline [NA] especially in patients with alcoholic dependence decreases in comparison with the control variant. As compared to the control variant the acute form of abstinence syndrome (1-3 days after cessation of the psychoactive substances is characterized by the higher level of the A and DA excretion and the lower level of the NA excretion (especially in patients with opium narcotic dependence). As compared to the preabstinence period under conditions of the acute abstinence syndrome there is an essential increase in the level of the A, NA, DOPA and DA excretion. As compared to the control variant the postabstinence period (10-20 days after cessation) is characterized by the lower level of the NA excretion, especially in patients with alcoholic dependence, and of DOPA. The level of DA decreases in patients with alcoholic dependence. As compared to the acute abstienence syndrome the postabstinence period differs by the lower level of the A, NA (especially in patients with alcoholic dependence), DOPA (only inpatients with alcoholic dependence) and of DA excretion.
Kharchenko
N K
NK
Synyts'kyĭ
V M
VM
Kovtun
T V
TV
Horban'
A Ie
AIe
Stohniĭ
N A
NA
Lebediev
D S
DS
Koval'
Z O
ZO
Trofimchuk
H Ie
HIe
D002395:Catecholamines / Q000378:metabolism*; D002492:Central Nervous System Depressants / Q000009:adverse effects*; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D009892:Opium / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*
D002395:Catecholamines; D002492:Central Nervous System Depressants; D000431:Ethanol; D009892:Opium