Hen egg white lysozyme vaccination induces acute shock in NOD mice.
To investigate whether vaccination could induce lethal shock and which mechanisms are involved in this phenomenon, we tested a panel of autoantigens or diabetes-irrelevant peptides or proteins in nonobese diabetic (NOD), Balb/c, and C57Bl/6 mice. Of the antigens tested, only nondiabetogenic hen egg white lysozyme induced a severe form of shock exclusively in NOD mice. The mechanism involved is suggestive of a Th(2)-mediated anaphylactic reaction possibly connected to activation of PAF and triggering of DIC.
Branisteanu
Dumitru D
DD
Department of Endocrinology, University of Medicine and Pharmacy "Gr. T. Popa" Iasi, Iasi, Romania.
Overbergh
Lutgart
L
Decallonne
Brigitte
B
Mathieu
Chantal
C
D000818:Animals; D002645:Chickens; D004529:Egg White; D051379:Mice; D008810:Mice, Inbred C57BL; D016688:Mice, Inbred NOD; D009113:Muramidase / Q000008:administration & dosage*; D012769:Shock / Q000139:chemically induced*; D014612:Vaccines / Q000009:adverse effects*
D014612:Vaccines; D009113:Muramidase