[Meta-analysis for relationship between apoE gene polymorphism and coronary heart disease].
OBJECTIVE
To evaluate relationship between ApoE gene polymorphism and coronary heart disease (CHD).


METHODS
Meta-analysis was applied with a random-effect model for the collected data.


RESULTS
Difference in pooled frequencies, d, of apoE genotypes E3/2, E4/2, E3/3, E4/3 and E4/4 between case and control groups were 2.3%, -0.8%, -8.5%, 10.5% and 0.9%, respectively. Difference in pooled frequencies, d, of apoE alleles epsilon2, epsilon3 and epsilon4 were -1.5%, -4.2% and 5.8%, respectively, with a statistical significance between four groups.


CONCLUSIONS
apoE gene polymorphism was involved in coronary heart disease. Persons with apoE E3/3 genotype or epsilon3 allele were not susceptible to CHD, but those with apoE E4/4 genotype or epsilon4 allele had higher risk suffering from CHD than others.
Wang
Chun-Hong
CH
Department of Hygiene, School of Public Health, Wuhan University, Wuhan 430071, China.
Zhou
Xin
X
D001057:Apolipoproteins E / Q000235:genetics*; D003327:Coronary Disease / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic
D001057:Apolipoproteins E