[Study on association between CC16 gene G38A mutation and asthma in the patients of Han population in Chongqing, China].
OBJECTIVE
To investigate the possible association between polymorphism of CC16 gene exon 1 and asthma, the genotype and allele frequencies of CC16 gene exon 1 in the asthmatic patients of Han population in southwest China were analyzed.


METHODS
The authors determined the genotypes of CC16 gene exon 1 with polymerase chain reaction technique and restricted enzyme analysis, and then compared the genotype and allele frequencies of the gene of the asthmatic group with those of the healthy control group.


RESULTS
There was no significant difference in genotype and allele frequencies of CC16 gene between the asthmatic group and control group. There was no association between the genotype and allele frequencies of gene and the severity of asthma.


CONCLUSIONS
CC16 gene may be not a susceptibility gene of asthmatic patients of Han population in southwest China.
Gui
Qing
Q
Respiration Institute of Xinqiao Hospital, the Third Military Medical University, Chongqing, 400037 PR China. qinggui3472@sina.com.cn
Qian
Gui-sheng
GS
Huang
Gui-jun
GJ
Li
Shu-ping
SP
D000328:Adult; D000368:Aged; D000483:Alleles; D001249:Asthma / Q000235:genetics*; D002681:China / Q000208:ethnology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D011506:Proteins / Q000235:genetics*; D014598:Uteroglobin
D011506:Proteins; C556389:SCGB1A1 protein, human; D014598:Uteroglobin