Antibacterial xanthones from the leaves of Garcinia nigrolineata.
Ten new 1,3,5-trioxygenated xanthones, nigrolineaxanthones J-S (1-10), one new quinone derivative, nigrolineaquinone A (11), and one new isoflavone-like compound, nigrolineaisoflavone A (12), were isolated from the leaves of Garcinia nigrolineata along with four known xanthones and friedelin. Among the xanthones, only nigrolineaxanthone N (5) showed significant antibacterial activity against methicillin-resistant Staphylococcus aureus.
Rukachaisirikul
Vatcharin
V
Department of Chemistry, Faculty of Science, Prince of Songkla University, Songkhla, 90112, Thailand. rvatchar@ratree.psu.ac.th
Kamkaew
Mayuree
M
Sukavisit
Dusadee
D
Phongpaichit
Souwalak
S
Sawangchote
Prakart
P
Taylor
Walter C
WC
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D029760:Garcinia / Q000737:chemistry*; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016106:Methicillin Resistance; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*; D013785:Thailand; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000094042:Lupanes
D000900:Anti-Bacterial Agents; D007529:Isoflavones; D011809:Quinones; D014315:Triterpenes; D044004:Xanthones; C482742:nigrolineaisoflavone A; C482743:nigrolineaquinone A; C060796:friedelin; D000094042:Lupanes