A 6-base pair insertion in the protease gene of HIV type 1 detected in a protease inhibitor-naive patient is not associated with indinavir treatment failure.
Insertions in the protease gene of HIV-1 were rarely found and are not associated with reduced effectiveness of protease inhibitors although they are thought to be selected by protease inhibitor therapy. This is the first report of a 6-basepair insertion in the protease gene prior to protease inhibitor therapy.
Stürmer
Martin
M
Institute for Medical Virology, Johann Wolfgang-Goethe University-Clinic, Frankfurt/Main, Germany. M.STUERMER@EM.UNI-FRANKFURT.DE
Staszewski
Schlomo
S
Doerr
Hans W
HW
Hertogs
Kurt
K
D020029:Base Pairing; D001483:Base Sequence; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology; D016333:HIV Protease / Q000235:genetics*; D017320:HIV Protease Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D015497:HIV-1 / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D019469:Indinavir / Q000494:pharmacology / Q000627:therapeutic use*; D009154:Mutation; D017211:Treatment Failure; D019562:Viral Load
D017320:HIV Protease Inhibitors; D019469:Indinavir; D016333:HIV Protease