Phenolic thiazoles as novel orally-active neuroprotective agents.
Novel phenolic thiazoles compounds were prepared which demonstrated potent antioxidant activity and potent in vivo neuroprotection in mitochondrial toxin models and also possess good oral bioavailability.
Harnett
Jeremiah J
JJ
Department of Medicinal Chemistry, Ipsen Research Laboratories, Institute Henri Beaufour, 5 Avenue du Canada, 91966 Les Ulis Cedex, France. jeremiah.harnett@ipsen.com
Roubert
Veronique
V
Dolo
Christine
C
Charnet
Christelle
C
Spinnewyn
Brigitte
B
Cornet
Sylvie
S
Rolland
Alain
A
Marin
Jean-Gregoire
JG
Bigg
Dennis
D
Chabrier
Pierre-E
PE
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D020267:MPTP Poisoning / Q000378:metabolism / Q000517:prevention & control; D051379:Mice; D018696:Neuroprotective Agents / Q000008:administration & dosage* / Q000737:chemistry; D010636:Phenols / Q000008:administration & dosage* / Q000737:chemistry; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism; D013844:Thiazoles / Q000008:administration & dosage* / Q000737:chemistry
D000975:Antioxidants; D018696:Neuroprotective Agents; D010636:Phenols; D013844:Thiazoles