Chemokines in eosinophil-associated gastrointestinal disorders.
Eosinophil-associated gastrointestinal disorders (EGDs) are characterized by a pronounced cellular inflammation. Recent clinical and experimental investigations have implicated a family of molecules known as chemokines in the regulation of leukocyte recruitment in these diseases. The underlying cellular and molecular mechanisms involved in chemokine-mediated cellular infiltration are largely unknown. In this review, we describe the role of CD4+ T cells and eosinophils in the clinical manifestations of EGDs and discuss the current understanding of the role of chemokines in the recruitment of these cells in the expression of diseases.
Hogan
Simon P
SP
Division of Molecular Bioscience, John Curtin School of Medical Research, Australian National University, PO Box 334, Canberra, Australia 0200. Simon.Hogan@anu.edu.au
Rothenberg
Marc E
ME
Forbes
Elizabeth
E
Smart
Vanessa E
VE
Matthaei
Klaus I
KI
Foster
Paul S
PS
D000818:Animals; D002465:Cell Movement / Q000502:physiology; D018925:Chemokines / Q000276:immunology* / Q000378:metabolism; D002631:Chemotactic Factors, Eosinophil / Q000276:immunology* / Q000502:physiology; D004802:Eosinophilia / Q000503:physiopathology*; D005767:Gastrointestinal Diseases / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology / Q000502:physiology; D018836:Inflammation Mediators / Q000378:metabolism; D018570:Risk Assessment; D012680:Sensitivity and Specificity
D018925:Chemokines; D002631:Chemotactic Factors, Eosinophil; D018836:Inflammation Mediators