title: [The NAD(P)H: quinone oxidoreductase 1 C609T polymorphism and susceptibility to esophageal cancer].
abstract: OBJECTIVE
  To investigate the association of the NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with susceptibility to esophageal squamous cell carcinoma (ESCC) in a northern Chinese population.
  
  
  METHODS
  The NQO1 C609T genotypes were determined by polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) analysis in 193 patients with ESCC and 141 unrelated healthy controls.
  
  
  RESULTS
  The frequency of the T allele (null) among ESCC patients was significantly higher than that among healthy controls (Chi-square=4.86, P=0.028). The NQO1 C/C and C/T genotype distribution among ESCC patients was not significantly different from that among healthy controls (Chi-square= 2.27 and 0.127; P=0.132 and 0.721, respectively). However, the T/T genotype frequency among ESCC patients was significantly higher than that among healthy controls (Chi-square=4.39, P=0.036). The NQO1 T/T genotype significantly increased the risk for developing ESCC, compared to the combination of C/C and C/T genotypes, with the adjusted odds ratio (OR) of 1.81 (95%CI: 1.04-3.15). This increased susceptibility exhibited pronouncedly in patients with family history of upper gastrointestinal cancers (adjusted OR=2.22, 95%CI 1.18-4.17).
  
  
  CONCLUSIONS
  Determination of the NQO1 C609T genotype may be used as a stratification marker to predicate high-risk individuals for ESCC.
authors.affiliation: Laboratory of Molecular Biology, Hebei Cancer Institute, Shijiazhuang, Hebei, 050011 PR China. jianhuizh@hotmail.com
authors.forename: Jian-hui
authors.initials: JH
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Mario
authors.initials: M
authors.lastname: Sarbia
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.forename: Deng-gui
authors.initials: DG
authors.lastname: Wen
authors.forename: Li-zhen
authors.initials: LZ
authors.lastname: Wei
authors.forename: Zhi-feng
authors.initials: ZF
authors.lastname: Chen
authors.forename: Gang
authors.initials: G
authors.lastname: Kuang
authors.forename: Li-wei
authors.initials: LW
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: He
authors.forename: Ming-li
authors.initials: ML
authors.lastname: Wu
authors.forename: Shi-jie
authors.initials: SJ
authors.lastname: Wang
mesh_terms: D004938:Esophageal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human