Synthesis, antioxidant and antiinflammatory activity of novel aryla-cetic and aryl-hydroxamic acids.
Four new aryl-acetic acids and the corresponding hydroxamic acids were synthesized. These compounds showed interesting interaction with the free radical 1,1-diphenyl-2-picryl-hydrazyl (DPPH), scavenging activity on .OH, inhibition of soybean lipoxygenase and a significant inhibition of carrageenin induced paw edema in rats (44.1-70.9%) at a concentration of 0.01 mmol/100 g.
Pontiki
Eleni A
EA
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki, Greece.
Hadjipavlou-Litina
Dimitra J
DJ
D000085:Acetates / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001713:Biphenyl Compounds; D002351:Carrageenan; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004121:Dimethyl Sulfoxide; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005609:Free Radicals; D006877:Hydroxamic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D010084:Oxidation-Reduction; D010851:Picrates / Q000737:chemistry; D051381:Rats
D000085:Acetates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D001713:Biphenyl Compounds; D005609:Free Radicals; D006877:Hydroxamic Acids; D007202:Indicators and Reagents; D016859:Lipoxygenase Inhibitors; D010851:Picrates; D002351:Carrageenan; C004931:1,1-diphenyl-2-picrylhydrazyl; D004121:Dimethyl Sulfoxide