Evidence for a relationship between Group 1 mGluR hypofunction and increased cocaine and ethanol sensitivity in Homer2 null mutant mice.
Szumlinski
Karen K
KK
Department of Physiology and Neuroscience and Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA.
Toda
Shigenobu
S
Middaugh
Lawrence D
LD
Worley
Paul F
PF
Kalivas
Peter W
PW
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics* / Q000502:physiology*; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D000072233:Homer Scaffolding Proteins; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D018345:Mice, Knockout; D009043:Motor Activity / Q000187:drug effects; D009473:Neuronal Plasticity / Q000502:physiology; D009479:Neuropeptides / Q000235:genetics* / Q000502:physiology*; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics / Q000502:physiology*; D012201:Reward; D019966:Substance-Related Disorders / Q000503:physiopathology
D002352:Carrier Proteins; D002492:Central Nervous System Depressants; D018690:Excitatory Amino Acid Agonists; D000072233:Homer Scaffolding Proteins; C000606625:Homer2 protein, mouse; D009479:Neuropeptides; D018094:Receptors, Metabotropic Glutamate; C104077:metabotropic glutamate receptor type 1; D000431:Ethanol; D008734:Methoxyhydroxyphenylglycol; D003042:Cocaine; C010117:3,4-dihydroxyphenylglycol