Interdigitating dendritic cell sarcoma of salivary gland associated lymphoid tissue not associated with HHV-8 or EBV infection.
Interdigitating dendritic cell sarcoma (IDCS) is an extremely rare malignancy derived from professional antigen presenting cells. This report describes a case of IDCS arising in the salivary gland associated lymphoid tissue of the parotid gland of a 51 year woman, presenting with a painless neck swelling. Histologically, sheets of S100(+)/Ccd68(+)/CD45(+)/CD34(-)/CD1a(-) spindle cells were surrounded with an inflammatory infiltrate with no evidence of B or T cell clonal proliferations. No evidence of either human herpesvirus 8 or Epstein-Barr virus could be detected by quantitative polymerase chain reaction in the tumour cells with serological evidence of previous Epstein-Barr virus infection. The patient remains well and disease free 24 months after presentation without specific treatment.
Barwell
N
N
Department of Haematology, Monklands Hospital, Airdrie ML6 0JS, UK.
Howatson
R
R
Jackson
R
R
Johnson
A
A
Jarrett
R F
RF
Cook
G
G
D004279:DNA, Viral / Q000032:analysis; D003713:Dendritic Cells / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D019288:Herpesvirus 8, Human / Q000302:isolation & purification; D006801:Humans; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000473:pathology* / Q000821:virology; D012509:Sarcoma / Q000473:pathology* / Q000821:virology
D004279:DNA, Viral