title: Effects of Unkei-to on FSH, LH and estradiol in anovulatory young women with hyper- or hypo-functioning conditions.
abstract: Eight weeks treatment with Unkei-to induced a significant increase in plasma follicle stimulating hormone (FSH), luteinizing hormone (LH) and estradiol levels in hyper- (robust) and hypo- (asthenia) functioning patients with first- and second-grade amenorrhea. We observed no significant differences in the rate of change of these hormones between hyper- and hypo-functioning patients. Ovulation occurred in 61.3% and 66.7% of patients with first-grade amenorrhea, and in 27.3% and 22.4% of patients with second-grade amenorrhea, respectively. No significant difference was observed in the ovulation rate after an 8-week treatment with Unkei-to between hyper- and hypo-functioning patients. These results indicate that Unkei-to is effective in improving gonadotropin and estradiol secretion in the treatment of either hyper- or hypo-functioning anovulatory women.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka Medical College, Takatsuki, Osaka 569-8686, Japan. gyn003@poh.osaka-med.ac.jp
authors.forename: Takahisa
authors.initials: T
authors.lastname: Ushiroyama
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Hosotani
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Yamashita
authors.forename: Minoru
authors.initials: M
authors.lastname: Ueki
mesh_terms: D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D006062:Gonadotropins / Q000378:metabolism; D006801:Humans; D007986:Luteinizing Hormone / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010060:Ovulation / Q000187:drug effects*; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D006062:Gonadotropins; C058415:unkei-to; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone