title: An efficient two-step total synthesis of the quaterpyridine nemertelline.
abstract: Regioselective and univocal Suzuki cross-coupling reactions performed on halopyridinyl boronic acids provide a flexible and versatile route to a multigram scale synthesis of 2,2'-dichloro-3,4'-bipyridine 14, which allows couplings with excess pyridin-3-yl boronic acid to give a new and efficient two-step rapid synthesis of nemertelline, the quaterpyridine neurotoxin isolated from a Hoplonemertine sea worm.
authors.affiliation: Centre d'Etudes et de Recherche sur le Médicament de Normandie, UFR des Sciences Pharmaceutiques, 5 rue Vaubénard, 14032 Caen, France.
authors.forename: Alexandre
authors.initials: A
authors.lastname: Bouillon
authors.forename: Anne Sophie
authors.initials: AS
authors.lastname: Voisin
authors.forename: Audrey
authors.initials: A
authors.lastname: Robic
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Lancelot
authors.forename: Valérie
authors.initials: V
authors.lastname: Collot
authors.forename: Sylvain
authors.initials: S
authors.lastname: Rault
mesh_terms: D001897:Boronic Acids / Q000737:chemistry; D015394:Molecular Structure; D009498:Neurotoxins / Q000138:chemical synthesis*; D011725:Pyridines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D001897:Boronic Acids; D009498:Neurotoxins; D011725:Pyridines; C482881:nemertelline