Cortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I enzyme and reduced co-factor NADPH.
Several factors including genetic and environmental play a role in the development of obesity and the metabolic syndrome. The transgenic mouse overexpressing 11beta-hydroxysteroid dehydrogenase (11beta-HSD) develops visceral obesity. However, it remains unclear how a ubiquitously expressed 11beta-HSD1 enzyme affects adipose tissue so much that it would lead to obesity. In this commentary we explore the possibility that increased intracellular availability of reduced co-factor, NADPH, could exacerbate the enzymatic activity.
Agarwal
Anil K
AK
Division of Nutrition and Metabolic Diseases, Department of Internal Medicine, Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. anil.agarwal@utsouthwestern.edu
D042842:11-beta-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000818:Animals; D003349:Cortisone Reductase / Q000172:deficiency; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D009765:Obesity / Q000201:enzymology* / Q000378:metabolism*; D010427:Pentose Phosphate Pathway
D009249:NADP; D042842:11-beta-Hydroxysteroid Dehydrogenases; D003349:Cortisone Reductase; D006854:Hydrocortisone