Prevention of experimentally-induced gastric ulcers in rats by an ethanolic extract of "Parsley" Petroselinum crispum.
An ethanolic extract of Parsley, Petroselinum crispum (Mill.) Nym.ex A.W. Hill (Umbelliferae), was tested for its ability to inhibit gastric secretion and to protect gastric mucosa against the injuries caused by pyloric ligation, hypothermic restraint stress, indomethacin and cytodestructive agents (80% ethanol, 0.2 M NaOH and 25% NaCl) in rats. The extract in doses of 1 and 2 g/kg body weight had a significant antiulcerogenic activity on the models used. Besides, ethanol-induced depleted gastric wall mucus and non-protein sulfhydryl contents were replenished by pretreatment with Parsley extract. Acute toxicity tests showed a large margin of safety for the extract. The phytochemical screening of Parsley leaves revealed the presence of tannins, flavonoids, sterols and/or triterpenes.
Al-Howiriny
Tawfeq
T
Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
Al-Sohaibani
Mohammed
M
El-Tahir
Kamal
K
Rafatullah
Syed
S
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D006851:Hydrochloric Acid / Q000008:administration & dosage; D007036:Hypothermia, Induced; D007213:Indomethacin / Q000008:administration & dosage; D028528:Petroselinum / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D011708:Pylorus / Q000293:injuries; D051381:Rats; D017208:Rats, Wistar; D012972:Sodium Hydroxide / Q000008:administration & dosage; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D013997:Time Factors
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D000431:Ethanol; D012972:Sodium Hydroxide; D006851:Hydrochloric Acid; D007213:Indomethacin