The FEMA GRAS assessment of cinnamyl derivatives used as flavor ingredients.
This publication is the seventh in a series of safety evaluations performed by the Expert Panel of the Flavor and Extract Manufacturers Association (FEMA). In 1993, the Panel initiated a comprehensive program to re-evaluate the safety of more than 1700 GRAS flavoring substances under conditions of intended use. Elements that are fundamental to the safety evaluation of flavor ingredients include exposure, structural analogy, metabolism, pharmacokinetics and toxicology. Flavor ingredients are evaluated individually and in the context of the available scientific information on the group of structurally related substances. Scientific data relevant to the safety evaluation of the use of cinnamyl derivatives as flavoring ingredients is evaluated.
Adams
Timothy B
TB
Flavor and Extract Manufacturers Association, 1620 I Street, N.W., Suite 925, Washington, DC 20006, USA. tadams@therobertsgroup.net
Cohen
Samuel M
SM
Doull
John
J
Feron
Victor J
VJ
Goodman
Jay I
JI
Marnett
Lawrence J
LJ
Munro
Ian C
IC
Portoghese
Philip S
PS
Smith
Robert L
RL
Waddell
William J
WJ
Wagner
Bernard M
BM
D000171:Acrolein / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D000818:Animals; D002934:Cinnamates / Q000737:chemistry / Q000493:pharmacokinetics / Q000633:toxicity; D005421:Flavoring Agents / Q000737:chemistry / Q000493:pharmacokinetics* / Q000633:toxicity; D005503:Food Additives / Q000592:standards*; D019649:Food Industry; D006801:Humans; D007928:Lethal Dose 50; D020005:Propanols / Q000737:chemistry / Q000493:pharmacokinetics* / Q000633:toxicity; D051381:Rats; D012449:Safety; D018675:Toxicity Tests
D002934:Cinnamates; D005421:Flavoring Agents; D005503:Food Additives; D020005:Propanols; C029010:cinnamic acid; D000171:Acrolein; C012843:cinnamaldehyde; C020722:cinnamyl alcohol