[Chromosome Y microdeletions in Czech men with severe reproductive disorders].
BACKGROUND
The Y chromosome microdeletions belong to the frequent genetical causes of male infertility. The aim of our study was to introduce reliable molecular genetic diagnosis of Y chromosomal microdeletions and to determine the prevalence of Y chromosomal microdeletions in Czech males with serious reproductive disorders.


RESULTS
The Y chromosome microdeletions were screened in 198 Czech men with serious reproductive disorders with decreased sperm count. The Y chromosome microdeletions were disclosed in 8/198 (4.0%) examined males. The AZFc deletion type was revealed in 62.5% (5/8) and the combined AZFc + b microdeletion in 37.5% (3/8) of cases. Neither isolated AZFb nor AZFa microdeletion were found in any subject of the investigated group.


CONCLUSIONS
Incidence of individual types of Y chromosomal microdeletions in Czech males with serious reproductive disorders was assessed. The standardised molecular genetic diagnosis of Y chromosomal microdeletions was introduced into the practice.
Machatková
M
M
Ustav biologie a lékarské genetiky 2. LF UK a FNM, Praha. katarina.machatkova@lfmotol.cuni.cz
Krebsová
A
A
Smetanová
I
I
Matĕjcková
M
M
Vilímová
S
S
Sobek
A
A
Macek
M
M
D041322:Chromosomes, Human, Y / Q000235:genetics*; D017353:Gene Deletion; D056426:Genetic Loci; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D009845:Oligospermia / Q000235:genetics; D029589:Seminal Plasma Proteins / Q000235:genetics
D029589:Seminal Plasma Proteins