Advances in encoding of colloids for combinatorial libraries: applications in genomics, proteomics and drug discovery.
The creation of enormous libraries of chemicals and their subsequent screening for bioactivity has been accelerated through recent developments in encoding solid supports. The ability to accurately identify the structure of a biomolecule that has exhibited activity is invaluable and is closer to realisation in the advent of smart nanoscience. In this review the evolution of encoding solid supports as platforms for combinatorial synthesis is traced. Current approaches to encoding solid supports are reviewed and their potential for use as supports for the high-throughput screening of split and mix libraries explored. Finally, a brief consideration of the status of the application of encoded libraries is provided including creative chemical and colloidal encoding.
Lawrie
Gwendolyn A
GA
Centre for Nanotechnology and Biomaterials, Department of Chemistry, The University of Queensland, St. Lucia, QLD 4072, Australia.
Battersby
Bronwyn J
BJ
Grøndahl
Lisbeth
L
Trau
Matt
M
D001704:Biopolymers / Q000032:analysis / Q000737:chemistry*; D003102:Colloids / Q000138:chemical synthesis / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000295:instrumentation / Q000379:methods*; D015195:Drug Design; D015723:Gene Library; D023281:Genomics / Q000295:instrumentation / Q000379:methods*; D015335:Molecular Probes / Q000138:chemical synthesis / Q000737:chemistry*; D019151:Peptide Library; D040901:Proteomics / Q000295:instrumentation / Q000379:methods*
D001704:Biopolymers; D003102:Colloids; D015335:Molecular Probes; D019151:Peptide Library