Use of a gonadotropin-releasing hormone antagonist for endometrial maturation and synchronization in an ovum recipient.
OBJECTIVE
To report the novel use of hMG and the GnRH antagonist for endometrial preparation and synchronization in a woman participating in an ovum donation program who was resistant to endometrial preparation with estrogen replacement.


METHODS
Case report.


METHODS
Tertiary fertility center.


METHODS
The patient had inadequate endometrial maturation, as determined by pelvic ultrasound (thickness of <5 mm), after estrogen replacement. Ovarian hyperstimulation with hMG and a GnRH antagonist resulted in an endometrial thickness of 7.5 mm. Synchronization with a ovum donor resulted in a delivered twin gestation.


METHODS
: Late follicular transvaginal ultrasound.


METHODS
Appropriate endometrial maturation and pregnancy.


RESULTS
Appropriate endometrial maturation.


CONCLUSIONS
For women with inadequate endometrial maturation with simple estrogen replacement, ovarian hyperstimulation with hMG and a GnRH antagonist can yield appropriate endometrial maturation for pregnancy through ovum donation.
Hofmann
Glen E
GE
Bethesda Hospital, Cincinnati, Ohio, USA. hofmannge@aol.com
Sosnowski
James P
JP
Warikoo
Pradeep
P
Bertsche
Ann
A
D000328:Adult; D004717:Endometrium / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors*; D006801:Humans; D008297:Male; D010062:Ovulation Induction / Q000379:methods*; D010298:Parity; D011247:Pregnancy; D011256:Pregnancy Outcome
D007987:Gonadotropin-Releasing Hormone