Absence of the T-bet gene coding for the Th1-related transcription factor does not affect diabetes-associated phenotypes in Balb/c mice.
The T-box expressed in T cells gene (T-bet) is a member of the T-box family of transcription factors. T-bet-deficient mice show normal lymphoid development, but exhibit profound defects in their Th1-mediated immune responses. As the balance between Th1- and Th2-mediated immune responses plays a role in autoimmune-prone diseases, we have investigated the diabetes-related insulin autoantibody (IAA) and cellular immune responses (insulitis), in the absence of Th1 lineage commitment, in T-bet KO Balb/c mice, after immunization with the B9-23 insulin peptide. We have therefore investigated whether absence of the T-bet gene influences diabetes-related phenotypes in Balb/c T-bet KO mice.
Melanitou
Evie
E
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Science Center, Denver, Colorado 80262, USA. eviemel@pasteur.fr
Liu
Edwin
E
Miao
Dongmei
D
Yu
Liping
L
Glimcher
Laurie H
LH
Eisenbarth
George
G
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D010641:Phenotype; D020825:T-Box Domain Proteins; D014157:Transcription Factors / Q000235:genetics*; D000098815:T-bet Transcription Factor
D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D014157:Transcription Factors