title: Efficacy and safety of a new whole-blood low-density lipoprotein apheresis system (Liposorber D) in severe hypercholesterolemia.
abstract: Low-density lipoprotein (LDL) apheresis is an extracorporeal modality to lower LDL cholesterol. While most of the devices eliminate LDL particles from plasma, a recently introduced whole-blood perfusion column (DALI) adsorbs lipoproteins directly from whole blood. We investigated the efficacy and safety of a new whole-blood LDL apheresis system (Liposorber D) in 10 patients with severe hypercholesterolemia in a multicenter trial. In 93 LDL aphereses, the mean reduction in LDL cholesterol and lipoprotein(a) was 62.2 +/- 11.5% and 55.6 +/- 16.9%, respectively (P < 0.01). If hemodilution during apheresis was considered, the reductions were 58.0 +/- 10.9 and 55.3 +/- 10.9%, respectively (P < 0.01), while high-density lipoprotein (HDL) cholesterol did not change significantly. Three mild episodes of hypocalcemia and two mild episodes of arterial hypotension were observed; however, LDL apheresis could be continued in each case. In conclusion, the new whole-blood LDL apheresis with Liposorber D is a safe, simple, and useful modality to reduce LDL cholesterol and lipoprotein(a) in cardiovascular high-risk patients.
authors.affiliation: Medical Department 2-Grosshadern, University Hospital of Munich; Franz-von-Prümmer-Klinik, Bad Brückenau, Germany. carsten.otto@med2.med.uni-muenchen.de
authors.forename: Carsten
authors.initials: C
authors.lastname: Otto
authors.forename: Peter
authors.initials: P
authors.lastname: Kern
authors.forename: Rolf
authors.initials: R
authors.lastname: Bambauer
authors.forename: Stefan
authors.initials: S
authors.lastname: Kallert
authors.forename: Peter
authors.initials: P
authors.lastname: Schwandt
authors.forename: Klaus G
authors.initials: KG
authors.lastname: Parhofer
mesh_terms: D000328:Adult; D000368:Aged; D001781:Blood Component Removal / Q000295:instrumentation*; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D008078:Cholesterol, LDL