[The neuromuscular transmission effects induced by pralidoxine chloride on rats with acute isocarbophos poisoning].
OBJECTIVE
To study the effects of improving the neuromuscular transmission (NMT), "non-AChE-reactivating effects", by oximes in treating acute isocarbophos poisoning.


METHODS
The effect of pralidoxime chloride(PAM-Cl) on the neuromuscular transmission(NMT) in rats exposed to isocarbophos was studied by using the stimulation single fiber electromyography (SSFEMG) to determine the single fiber action potential.


RESULTS
After the rats exposed to isocarbophos were treated by PAM-Cl, the mean consecutive difference(MCD) value [(25.99 +/- 5.84) microsecond] of single fiber action potential was significantly lower than that before PAM-Cl treatment [(33.21 +/- 4.09) microsecond, (P < 0.01)], but no AChE reactivation in blood and gastrocnemius was observed.


CONCLUSIONS
PAM-Cl has "non-AChE-reactivating effects", it could markedly improve isocarbophos-induced NMT block of gastrocnemius.
Ju
Zhichang
Z
Institute of Nutritional and Food Hygiene, Bejing Center for Disease Prevention and Control, Beijing 100013, China.
Sun
Jinxiu
J
D000208:Acute Disease; D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D007306:Insecticides / Q000506:poisoning*; D008294:Malathion / Q000506:poisoning*; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D011220:Pralidoxime Compounds / Q000494:pharmacology*; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects*
D000931:Antidotes; D002800:Cholinesterase Inhibitors; D007306:Insecticides; D011220:Pralidoxime Compounds; C028797:pralidoxime; D008294:Malathion