Modeling transformation and metastasis in Drosophila.
Transformation and metastasis are complex, multistep processes. Two recent papers exploit powerful Drosophila genetics techniques to explore cooperation between multiple genetic manipulations and to model these processes. In particular, oncogenic Ras is found to collaborate with disruption of cell polarity to trigger massive neoplasia and metastasis. These studies promise further progress in research into the causes of cancer.
Tapon
Nicolas
N
Apoptosis and Proliferation Control Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, WC2A 3PX, London, United Kingdom
D022005:Adherens Junctions; D000818:Animals; D016764:Cell Polarity; D002471:Cell Transformation, Neoplastic; D004330:Drosophila / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D011905:Genes, ras / Q000235:genetics / Q000502:physiology*; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D023421:Models, Animal; D009362:Neoplasm Metastasis / Q000503:physiopathology; D009374:Neoplasms, Experimental / Q000235:genetics / Q000378:metabolism*; D051880:Receptors, Notch; D025521:Tumor Suppressor Proteins
D029721:Drosophila Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D051880:Receptors, Notch; C480591:SCRIB protein, human; C404683:Scrib protein, Drosophila; D025521:Tumor Suppressor Proteins