[Antimicrobial activity of hinokitiol against Legionella pneumophila].
Antimicrobial activity of hinokitiol (beta-thujaplicin), which is a major component of the essential oil of Chamaecyparis obtuse, against Legionella pneumophila was investigated experimentally. The quantitative antibacterial assay of hinokitiol was carried out by the disk-diffusion method. The test concentrations of hinokitiol were 0.39 to 25.0 micrograms/disk, and the lowest concentrations of hinokitiol that showed growth inhibition against L. pneumophila were 1.56 micrograms/disk on B-SYE agar and 0.39 microgram/disk on B-SYE agar without iron.
Ishimatsu
Sumiyo
S
Department of Environmental Management I, School of Health Sciences, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Ohga
Yuki
Y
Ishidao
Tohru
T
Hori
Hajime
H
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D029780:Chamaecyparis / Q000737:chemistry; D016952:Legionella pneumophila / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D039821:Monoterpenes / Q000494:pharmacology*; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology; D014334:Tropolone / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D039821:Monoterpenes; D009822:Oils, Volatile; D014334:Tropolone; C009479:beta-thujaplicin