The design and synthesis of novel inhibitors of NADH:ubiquinone oxidoreductase.
Potent new inhibitors of NADH:ubiquinone oxidoreductase (complex I) have been designed, with the help of molecular modelling, by hybridisation of known complex I inhibitors with inhibitors of cytochrome c oxidoreductase. The most interesting compound was the chromone 7 which was a selective inhibitor of complex I (IC(50) 15 nM) and showed acaricidal activity against spider mites.
Lindell
Stephen D
SD
Bayer CropScience GmbH, Werk Höchst, G836, D-65926, Frankfurt am Main, Germany. stephen.lindell@bayercropscience.com
Ort
Oswald
O
Lümmen
Peter
P
Klein
Robert
R
D000818:Animals; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D042967:Electron Transport Complex I / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006793:Houseflies; D027805:Phaseolus / Q000469:parasitology; D040102:Tetranychidae
D004791:Enzyme Inhibitors; D042967:Electron Transport Complex I