title: Perinatal outcome after prenatal diagnosis of placental chorioangioma.
abstract: OBJECTIVE
  To review the prenatal complications, management, and perinatal outcome in pregnancies complicated by placental chorioangioma.
  
  
  METHODS
  Cases of placental chorioangioma diagnosed prenatally as part of a prospective, multicentric program for fetal diagnosis and therapy were identified. All cases were evaluated with color flow imaging. In the latter part of the study, three-dimensional power Doppler angiography was also used to study the vascular pattern of the tumor. Information on maternal demographics, prenatal sonographic findings, pregnancy complications, antenatal intervention, and perinatal outcome was obtained by reviewing the medical records or contacting the referring obstetricians.
  
  
  RESULTS
  In the 5-year period from January 1997 to December 2001, 11 cases of placental chorioangioma were diagnosed prenatally. Nine cases were diagnosed in singleton and two in twin pregnancies. Among the nine cases occurring in singletons, five (56%) were associated with pregnancy complications, including polyhydramnios (n = 3), oligohydramnios (n = 2), fetal growth restriction (n = 2), and nonimmune hydrops (n = 1). Amniodrainage was required in one of these cases, allowing prolongation of pregnancy until term. Four (44%) singletons delivered before 35 weeks. Overall, two fetuses died, including one twin due to complications of twin-twin transfusion syndrome and another with hydrops after alcohol injection into the chorioangioma. In four pregnancies, no prenatal complications were detected in spite of continuous growth and vascularity of the placental mass in three of them.
  
  
  CONCLUSIONS
  Placental chorioangioma is associated with an increased risk of pregnancy complications, the most common being polyhydramnios and preterm delivery. In selected cases, amniodrainage allows continuation of the pregnancy with improving perinatal outcome. Fetuses who develop hydrops are at the highest risk for perinatal death, with limited therapeutic options being available. Close follow-up is advised, even in those cases with no associated findings at the time of the diagnosis.
authors.affiliation: Fetal Medicine Center, Department of Obstetrics and Gynecology, Clinica Las Condes, Santiago, Chile. waldosep@hotmail.com
authors.forename: Waldo
authors.initials: W
authors.lastname: Sepulveda
authors.forename: Juan L
authors.initials: JL
authors.lastname: Alcalde
authors.forename: Carlos
authors.initials: C
authors.lastname: Schnapp
authors.forename: Mariana
authors.initials: M
authors.lastname: Bravo
mesh_terms: D000328:Adult; D000792:Angiography; D002677:Chile / Q000453:epidemiology; D005260:Female; D006391:Hemangioma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008499:Medical Records; D010922:Placenta Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis; D011446:Prospective Studies; D012189:Retrospective Studies; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000209:etiology