An overview of the genetics of psychotic mood disorders.
This article presents a conceptual review of the genetic underpinnings of psychotic mood disorders. Both unipolar and bipolar forms of mood disorder sometimes feature psychotic symptoms. Some evidence from epidemiological research suggests that psychotic forms of mood disorder specifically might be heritable. Linkage studies of mood disorders in general have also provided some support for that notion, as have associated studies involving serotonin and dopamine genes and psychotic mood disorder. Some research suggests there might be a genetic connection between schizophrenia and bipolar disorder, undermining the Kraepelinian dichotomous classification of the psychoses. Future research should continue to examine psychotic forms of mood disorder using both epidemiological and molecular approaches.
Tsuang
Ming T
MT
Harvard Medical School Department of Psychiatry at the Massachusetts Mental Health Center, 74 Fenwood Road, Boston, MA, USA. ming_tsuang@hms.harvard.edu
Taylor
Levi
L
Faraone
Stephen V
SV
D000341:Affective Disorders, Psychotic / Q000175:diagnosis / Q000235:genetics*; D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics*; D002874:Chromosome Mapping; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008126:Lod Score; D011954:Receptors, Dopamine / Q000235:genetics; D011985:Receptors, Serotonin / Q000235:genetics; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*
D011954:Receptors, Dopamine; D011985:Receptors, Serotonin