Collective behaviour of crown channels.
Collective behaviour of a crown ether channel, bis[(benzo-15-crown-5)-15- yl methyl] pimelate, in a planar lipid bilayer membrane has been studied through electrophysiological methods. A characteristic feature of these channels is their sequential opening, indicated by a uniform stepwise increase in the multi-channel current. The experimental results show that there are three modes of relaxation, of which the slowest one is attributed to the channel-channel interaction. The latter varies with the number of channels incorporated in the bilayer membrane, leading to the interpretation that crown channels behave cooperatively.
Vijayvergiya
Viksita
V
Department of Biophysics, University of Delhi South Campus, 110021 New Delhi, India.
Bose
Debasish
D
Ghosh
Paramita
P
Ghosh
Subhendu
S
D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D001921:Brain / Q000378:metabolism; D002417:Cattle; D004553:Electric Conductivity; D004594:Electrophysiology; D004987:Ethers / Q000737:chemistry*; D007477:Ions; D008051:Lipid Bilayers / Q000737:chemistry*; D008081:Liposomes; D008956:Models, Chemical; D015233:Models, Statistical; D010713:Phosphatidylcholines / Q000737:chemistry; D010718:Phosphatidylserines / Q000737:chemistry; D011188:Potassium / Q000737:chemistry; D012964:Sodium / Q000737:chemistry
D004987:Ethers; D007477:Ions; D008051:Lipid Bilayers; D008081:Liposomes; D010713:Phosphatidylcholines; D010718:Phosphatidylserines; D012964:Sodium; D011188:Potassium