Paeoniflorin: an antihyperlipidemic agent from Paeonia lactiflora.
Paeoniflorin (1), isolated from the methanol extract of Paeonia lactiflora, showed a lowering effect on cholesterol level in the experimentally-induced hyperlipidemic rats. Paeoniflorin showed a significantly lowering effect of total cholesterol, LDL and triglyceride levels compared with the control group at the dose of 200 and 400 mg/kg, p.o. once a day for 4 weeks.
Yang
Hyun Ok
HO
Department of Molecular Medicine, Asan Institute for Life Sciences, University of Ulsan, Seoul 138-736, South Korea. hoyang@amc.seoul.kr
Ko
Woo Kyung
WK
Kim
Jae Youn
JY
Ro
Hwan Seong
HS
D000284:Administration, Oral; D000818:Animals; D001565:Benzoates / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001952:Bridged-Ring Compounds / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005960:Glucosides / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000517:prevention & control*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D039821:Monoterpenes; D029596:Paeonia; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood; D006027:Glycosides
D001565:Benzoates; D001952:Bridged-Ring Compounds; D002784:Cholesterol; D008078:Cholesterol, LDL; D005960:Glucosides; D000960:Hypolipidemic Agents; D039821:Monoterpenes; D010936:Plant Extracts; D014280:Triglycerides; C015423:peoniflorin; D006027:Glycosides