Immunity and the animation of the genome.
Expression of genes in the right place at the right time is fundamental to all of life. The ontogeny of effector and memory T cells is a robust example of this important principle. Although lymphocytes represent a late addition in animal evolution, they are serving as an exceptional model system to unlock the mysteries surrounding the way in which the genome is animated. It will be speculated here that further insight into fundamental principles of genome function may arise from study of immunity. Likewise, such information may be key to understanding and altering immunobiology.
Reiner
Steven L
SL
Abramson Family Cancer Research Institute and Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. sreiner@mail.med.upenn.edu
D000818:Animals; D017637:Clonal Deletion / Q000276:immunology*; D005544:Forecasting; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D018521:Plant Physiological Phenomena; D015398:Signal Transduction / Q000276:immunology*