The syntheses of tricyclic analogues of O6-methylguanine.
The syntheses of the novel pyrrolo[2,3-d]pyrimidine-based heterocycles as tricyclic analogues of O6-methylguanine are described. Compound 5 is a weak inhibitor of human O6-alkylguanine DNA alkyltransferase.
Hammond
David M
DM
Centre for Chemical Biology, Department of Chemistry, Krebs Institute, University of Sheffield, Brook Hill, Sheffield, UK S3 7HF.
Edmont
Dolorès
D
Hornillo-Araujo
Ana R
AR
Williams
David M
DM
D001665:Binding Sites; D003500:Cyclization; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000037:antagonists & inhibitors
D006147:Guanine; C008449:O-(6)-methylguanine; D019853:O(6)-Methylguanine-DNA Methyltransferase