[The influence of the time of death, Ca ions and NO on the reactivity of rat's caudal artery regulated by arginine-vasopressin].
The contraction of arteries is influenced by many factors. The aim of this research was to analyze how an artery's reactivity, regulated by arginine-vasopressin changes in time, from the moment of death onwards. The research was conducted on rats' perfundated caudal arteries in four different time groups, with reference to two independent empirical models: I--with the sole use of intracellular Ca ions; and model II--with the sole use of extracellular Ca ions. The influence of NO on the arteries was analyzed in the two models, with the use of the NOS inhibitor. The research had shown that with the passing of time, beginning from the moment of death onwards, the process of emission of intracellular Ca ions and the infusion/transport of Ca ions from extracellular areas/spaces is inhibited. The use of the NOS inhibitor increases the artery's reactivity provided that the infusion of Ca ions from extracellular areas is also prevalent.
Bloch-Bogusławska
Elzbieta
E
D000818:Animals; D017209:Apoptosis; D001127:Arginine Vasopressin / Q000378:metabolism*; D001158:Arteries / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D003643:Death; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D007425:Intracellular Membranes / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar; D012445:Sacrococcygeal Region; D013623:Tail / Q000098:blood supply; D013997:Time Factors
D004791:Enzyme Inhibitors; D001127:Arginine Vasopressin; D019001:Nitric Oxide Synthase; D002118:Calcium