O/w dispersions development containing liquid crystals.
Liquid crystals are defined as the intermediary state between solid and liquid and also called of mesomorphous phase or crystalline phase, presenting characteristics of the mentioned physical states. For the simple emulsions that intermediary phase can act as forms of encapsulation of drugs providing its controlled liberation and besides, it can increase cutaneous hydration. These characteristics evidences the differentiation of the developed formulations and the use of the same ones in the release of new cosmetic vehicles. In that research we use vegetable oils (coffee, tomato), mineral oil, surfactants like phosphorics esthers (fractions A and B) and distilled water as aqueous phase. The stable formulations were submitted to stability physic-chemical preliminary tests (pH values determination, electric conductivity values, centrifugation and thermal stress) and later the compositions were submitted to accelerated stability tests (cold-hot cycle in the following temperature conditions--4 +/- 2 degrees C, 25 +/- 2 degrees C and 45 +/- 2 degrees C). Crystalline phase was identified by microscopy polarization. The recently prepared formulations and aged formulations (after 30 days) were appraised for rheology.
Massaro
R C
RC
Faculty of Pharmaceutical Sciences of Ribeirão Preto, USP, Technology of Cosmetics, Brasile.
Zabagli
M S
MS
Souza
C R
CR
Oliveira
W P
WP
del Lama
D S
DS
da Rocha-Filho
P A
PA
D003358:Cosmetics / Q000032:analysis*; D003460:Crystallization; D004355:Drug Stability; D004655:Emulsions / Q000032:analysis*; D012212:Rheology; D013501:Surface-Active Agents / Q000737:chemistry; D013816:Thermodynamics
D003358:Cosmetics; D004655:Emulsions; D013501:Surface-Active Agents