Human protein reference database as a discovery resource for proteomics.
The rapid pace at which genomic and proteomic data is being generated necessitates the development of tools and resources for managing data that allow integration of information from disparate sources. The Human Protein Reference Database (http://www.hprd.org) is a web-based resource based on open source technologies for protein information about several aspects of human proteins including protein-protein interactions, post-translational modifications, enzyme-substrate relationships and disease associations. This information was derived manually by a critical reading of the published literature by expert biologists and through bioinformatics analyses of the protein sequence. This database will assist in biomedical discoveries by serving as a resource of genomic and proteomic information and providing an integrated view of sequence, structure, function and protein networks in health and disease.
Peri
Suraj
S
McKusick-Nathans Institute of Genetic Medicine and Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21287, USA.
Navarro
J Daniel
JD
Kristiansen
Troels Z
TZ
Amanchy
Ramars
R
Surendranath
Vineeth
V
Muthusamy
Babylakshmi
B
Gandhi
T K B
TK
Chandrika
K N
KN
Deshpande
Nandan
N
Suresh
Shubha
S
Rashmi
B P
BP
Shanker
K
K
Padma
N
N
Niranjan
Vidya
V
Harsha
H C
HC
Talreja
Naveen
N
Vrushabendra
B M
BM
Ramya
M A
MA
Yatish
A J
AJ
Joy
Mary
M
Shivashankar
H N
HN
Kavitha
M P
MP
Menezes
Minal
M
Choudhury
Dipanwita Roy
DR
Ghosh
Neelanjana
N
Saravana
R
R
Chandran
Sreenath
S
Mohan
Sujatha
S
Jonnalagadda
Chandra Kiran
CK
Prasad
C K
CK
Kumar-Sinha
Chandan
C
Deshpande
Krishna S
KS
Pandey
Akhilesh
A
D019295:Computational Biology; D030562:Databases, Protein; D004194:Disease; D023281:Genomics; D006801:Humans; D016247:Information Storage and Retrieval; D020407:Internet; D011485:Protein Binding; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020543:Proteome / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D040901:Proteomics; D013379:Substrate Specificity; D018875:Vocabulary, Controlled
D011506:Proteins; D020543:Proteome