Failure of thymidine kinase-negative herpes simplex virus to reactivate from latency following efficient establishment.
Thymidine kinase-negative mutants of herpes simplex virus did not reactivate from latency in mouse trigeminal ganglia, even when their latent viral loads were comparable to those that permitted reactivation by wild-type virus. Thus, reduced establishment of latency does not suffice to account for the failure to reactivate.
Chen
Shih-Heng
SH
Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan 70101, Republic of China.
Pearson
Angela
A
Coen
Donald M
DM
Chen
Shun-Hua
SH
D000818:Animals; D006561:Herpes Simplex / Q000821:virology; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009154:Mutation; D018139:Simplexvirus / Q000201:enzymology / Q000235:genetics / Q000502:physiology*; D013937:Thymidine Kinase / Q000235:genetics / Q000378:metabolism*; D012668:Trigeminal Ganglion / Q000821:virology*; D014775:Virus Activation; D017735:Virus Latency
D013937:Thymidine Kinase