title: Prognostic implications of the degree of shunt narrowing and of the portal vein diameter in dogs with congenital portosystemic shunts.
abstract: OBJECTIVE
  To determine prognostic evaluation and correlation of the degree of narrowing and the diameter of the portal vein in dogs with a congenital portosystemic shunt (CPS).
  
  
  METHODS
  Longitudinal prospective study.
  
  
  METHODS
  Ninety-seven dogs with CPS.
  
  
  METHODS
  Shunt diameter was recorded before and after silk ligation to calculate degree of closure. Portal vein diameter was measured in 74 dogs. Short-term (30 days) and long-term (>1 year) outcome were evaluated. Dogs with clinical signs after 1 year were re-examined to assess the degree of portosystemic shunting and compared with matched operated dogs without clinical signs. Correlations between clinical outcome, degree of closure, and portal vein diameter were statistically analyzed.
  
  
  RESULTS
  Short-term and long-term mortality were 27% and 2.9% respectively. Clinical recurrence occurred in 10% of dogs. The degree of closure was significantly associated with mortality, but not with clinical recurrence. A significant correlation was found between degree of closure and the diameter of the cranial part of the portal vein. Portal vein diameter was only significantly associated with mortality in extrahepatic CPS. Subclinical portosystemic shunting was confirmed in 3 of 10 dogs.
  
  
  CONCLUSIONS
  The degree of shunt closure depended on portal development. Long-term outcome did not depend on the degree of closure or portal development at the time of surgery. This suggested that factors such as hepatic and portal regeneration after surgery may be important.
  
  
  CONCLUSIONS
  Determination of factors that predict the outcome after surgical treatment of CPS in dogs is important to gain insight in treatment selection or new therapeutic options.
authors.affiliation: Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
authors.forename: Anne
authors.initials: A
authors.lastname: Kummeling
authors.forename: Frederik J
authors.initials: FJ
authors.lastname: Van Sluijs
authors.forename: Jan
authors.initials: J
authors.lastname: Rothuizen
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D004285:Dogs; D005260:Female; D006975:Hypertension, Portal / Q000401:mortality / Q000473:pathology / Q000662:veterinary*; D008137:Longitudinal Studies; D008297:Male; D009426:Netherlands; D011168:Portal System / Q000002:abnormalities* / Q000473:pathology; D011169:Portal Vein / Q000473:pathology*; D011379:Prognosis; D011446:Prospective Studies; D011996:Records / Q000662:veterinary; D012720:Severity of Illness Index; D016896:Treatment Outcome