Tricholomalides A-C, new neurotrophic diterpenes from the mushroom Tricholoma sp.
Three new diterpenes, tricholomalides A-C (1-3), were isolated from the methanol extract of the fruiting body of Tricholoma sp. Their structures were elucidated on the basis of their spectral data, and the absolute configuration of 1 was determined by CD spectrum. Tricholomalides 1-3 significantly induced neurite outgrowth in rat pheochromocytoma cells (PC-12) at concentrations of 100 microM.
Tsukamoto
Sachiko
S
Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-0934, Japan.
Macabalang
Abdulgafor D
AD
Nakatani
Keigo
K
Obara
Yutaro
Y
Nakahata
Norimichi
N
Ohta
Tomihisa
T
D000363:Agaricales / Q000737:chemistry*; D000818:Animals; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016716:PC12 Cells; D051381:Rats
D004224:Diterpenes; D009414:Nerve Growth Factors; C482765:tricholomalide A; C482766:tricholomalide B; C482767:tricholomalide C