Drug-induced nail abnormalities.
A large number of drugs may be responsible for the development of nail changes, including cancer chemotherapeutic agents and retinoids, however, only a few classes of drugs are consistently associated with nail symptoms. Drug-induced nail abnormalities result from toxicity to the matrix, the nail bed, the periungual tissues or the digit blood vessels. The most common symptoms include Beau's lines, onychomadesis, melanonychia, onycholysis and periungual pyogenic granulomas. Drug-induced nail changes usually involve several or all of the nails. In most cases, nail abnormalities are asymptomatic, but can sometimes cause pain and impair manual activities.
Piraccini
Bianca Maria
BM
Department of Dermatology, University of Bologna, Via Massarenti, 1 - 40138 Bologna, Italy. bmpiracc@med.unibo.it
Iorizzo
Matilde
M
Antonucci
Angela
A
Tosti
Antonella
A
D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D009260:Nail Diseases / Q000139:chemically induced* / Q000473:pathology; D009262:Nails / Q000098:blood supply / Q000473:pathology; D009264:Nails, Malformed / Q000139:chemically induced / Q000473:pathology; D010859:Pigmentation Disorders / Q000139:chemically induced / Q000473:pathology; D012039:Regional Blood Flow