Transcriptome analysis of the response of Pseudomonas aeruginosa to hydrogen peroxide.
Pseudomonas aeruginosa must often overcome a high concentration of oxidants to successfully infect the human host. We report here the results of a transcriptome profiling comparing cells treated with H(2)O(2) and untreated controls. The data indicate that the early response of P. aeruginosa to H(2)O(2) consists of an upregulation of protective mechanisms and a downregulation of primary metabolism.
Palma
Marco
M
Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA.
DeLuca
Darrow
D
Worgall
Stefan
S
Quadri
Luis E N
LE
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D016680:Genome, Bacterial; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D016877:Oxidants / Q000494:pharmacology*; D018384:Oxidative Stress; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic
D001426:Bacterial Proteins; D016877:Oxidants; D012333:RNA, Messenger; D006861:Hydrogen Peroxide