title: Differential effects of surgical sympathetic block at the T2 and T4 level on vasoconstrictor function.
abstract: Endoscopic sympathetic block (ESB) is used as a treatment of excessive palmar sweating. In a prospective study we compared the effect of ESB at the level of the second (T2) and fourth thoracic ganglion (T4) on vasoconstriction and sweating of the hands. Sympathetic vasoconstriction was measured by computerassisted infrared thermography following ice water immersion of the hands in 22 hyperhidrosis patients before, two days and 3 months post op. In addition, palmar sweating before and 3 months post op was assessed by sudometry. After ESB the rewarming was accelerated in both T2 and T4 patients, but was significantly slower in the T4 group. Three months postoperatively rewarming had returned to the preoperative pattern in T4 patients but was still significantly faster in the T2 group. These effects were more pronounced in the fingertips than the hand dorsum. Sudomotor function was blocked in all T2 patients but had relapsed in 2 patients in the T4 group. Two T4 patients had not shown an effect on sudomotor function postoperatively. The normalization of rewarming kinetics may be explained by remaining fibers, denervation hypersensitivity or stimulation of catecholamine receptors, or neuronal reorganization. The effect of ESB T4 on sudomotor function has to be proven.
authors.affiliation: Dept. of Surgery, University of Erlangen-Nürnberg, Krankenhausstrasse 12, 91054, Erlangen, Germany.
authors.forename: Sophie
authors.initials: S
authors.lastname: Krüger
authors.forename: Kerstin S
authors.initials: KS
authors.lastname: Fronek
authors.forename: Martin
authors.initials: M
authors.lastname: Schmelz
authors.forename: Thomas
authors.initials: T
authors.lastname: Horbach
authors.forename: Werner
authors.initials: W
authors.lastname: Hohenberger
authors.forename: Christoph H
authors.initials: CH
authors.lastname: Schick
mesh_terms: D000328:Adult; D001340:Autonomic Nerve Block / Q000379:methods*; D005260:Female; D005385:Fingers; D006225:Hand; D006358:Hot Temperature; D006801:Humans; D006945:Hyperhidrosis / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D011184:Postoperative Period; D011446:Prospective Studies; D020775:Thoracic Surgery, Video-Assisted / Q000379:methods*; D013997:Time Factors; D014661:Vasoconstriction