Cyclin-dependent kinase 5 and neuronal migration in the neocortex.
The cyclin-dependent kinase 5 (Cdk5) plays an important role in the proper establishment of neocortical layers. Over the past several years, key molecular targets of Cdk5 have been identified that show intriguing connections to the adhesional and cytoskeletal components of cell movement. This molecular knowledge about Cdk5 signaling has begun to translate into an understanding of how Cdk5 regulates the cellular physiology of neocortical layer formation. Together with recent progress on the signaling relationship between Cdk5 and Reelin, the other key protein involved in neocortical layer formation, and their relationship to migration modes, research on understanding neocortical layer formation has arrived at a most promising crossroad.
Gupta
Amitabh
A
Department of Pathology, Harvard Medical School and Howard Hughes Medical Institute, Boston, Mass. 02115, USA.
Tsai
Li-Huei
LH
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D002478:Cells, Cultured; D051360:Cyclin-Dependent Kinase 5; D018844:Cyclin-Dependent Kinases / Q000235:genetics / Q000502:physiology*; D015509:Developmental Biology; D019579:Neocortex / Q000166:cytology / Q000201:enzymology* / Q000254:growth & development; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000201:enzymology*; D015398:Signal Transduction / Q000502:physiology
D009419:Nerve Tissue Proteins; C089495:neuronal Cdk5 activator (p25-p35); D051360:Cyclin-Dependent Kinase 5; D018844:Cyclin-Dependent Kinases