title: Effects of experimentally induced inflammation on temporomandibular joint nociceptors in rats.
abstract: Response properties of nociceptors in the temporomandibular joint (TMJ) and surrounding area under experimental inflammation were investigated using an in vitro TMJ-nerve preparation in the rat. Nociceptive units (receptor and innervating nerve fiber) were classified into the following subtypes: Adelta-high-threshold mechanonociceptor (HTM), Adelta-polymodal nociceptor (POLY), C-HTM and C-POLY. In the inflamed joint, mechanical thresholds tended to be lower; however, the reaction to bradykinin was not identified as clearly as in control. Experimentally induced inflammation increased the proportion of heat-sensitive units and lowered heat threshold significantly. These results suggest that inflammation may sensitize nociceptors in the temporomandibular joint, and cause hyperalgesia and allodynia.
authors.affiliation: Maxillofacial Surgery, Maxillofacial Reconstruction, Division of Maxillofacial and Neck Reconstruction, Graduate School, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8549, Japan.
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Zeredo
authors.forename: Rie
authors.initials: R
authors.lastname: Fujiyama
authors.forename: Teruo
authors.initials: T
authors.lastname: Amagasa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Toda
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D018771:Arthralgia / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D001168:Arthritis / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D001920:Bradykinin / Q000494:pharmacology; D002351:Carrageenan / Q000494:pharmacology; D004195:Disease Models, Animal; D006930:Hyperalgesia / Q000473:pathology / Q000503:physiopathology; D007616:Kaolin; D008465:Mechanoreceptors / Q000187:drug effects / Q000502:physiology; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000502:physiology; D036421:Nerve Fibers, Unmyelinated / Q000187:drug effects / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology*; D017288:Pain Threshold / Q000187:drug effects / Q000502:physiology; D010812:Physical Stimulation; D051381:Rats; D017208:Rats, Wistar; D011984:Sensory Receptor Cells / Q000187:drug effects / Q000502:physiology*; D013704:Temporomandibular Joint / Q000294:innervation* / Q000473:pathology / Q000503:physiopathology; D013705:Temporomandibular Joint Disorders / Q000139:chemically induced / Q000503:physiopathology*
chemical_list: D007616:Kaolin; D002351:Carrageenan; D001920:Bradykinin