title: [External beam radiation in treatment of subfoveal vascularized pigment epithelium detachment in age-related macular degeneration. Long-term results of a pilot study].
abstract: OBJECTIVE
  The purpose of this study was to contribute to the evaluation of long-term external beam radiation treatment in patients with subfoveal occult choroidal neovessels complicated with pigment epithelium detachment in age-related macular degeneration.
  
  
  METHODS
  This was a retrospective study of ten patients with a mean age of 75 years and a mean follow-up of 18.7 months. External beam radiation of 14.4 Gy was administered with a daily dose of 1.8 Gy. The efficacy of the treatment was assessed based on visual acuity, the size of the membrane and the persistence or not of neovascular activity.
  
  
  RESULTS
  We observed stabilization of visual acuity in 44% of the cases at 6 months but only in 20% at 19 and 30 months. The mean initial visual acuity was measured at 0.2 at presentation and 0.1 at the final evaluation. At the end of the study, 60% of patients attained the level of legal blindness; 90% of patients developed a disciform scar, with persistence of neovascular activity in 27% of the cases. On fluorescein angiography, the size of pigment epithelium detachment increased more than one optic disc diameter in 20% of the cases at 1 year. On the other hand, no radiation complication was observed.
  
  
  CONCLUSIONS
  The visual and anatomical results of our study are similar to the natural progression of occult neovascular membrane. External beam radiation at a dose of 14.4 Gy did not seem to provide a long-term benefit in the treatment of subfoveal occult neovessels associated with pigment epithelium detachment.
authors.affiliation: Service d'Ophtalmologie, CHU Gabriel Montpied, Place Henri Dunant, 63000 Clermont-Ferrand. marion.patte@wanadoo.fr
authors.forename: M
authors.initials: M
authors.lastname: Patte
authors.forename: M
authors.initials: M
authors.lastname: Donnarieix
authors.forename: J-L
authors.initials: JL
authors.lastname: Achard
authors.forename: R
authors.initials: R
authors.lastname: Rozan
authors.forename: F
authors.initials: F
authors.lastname: Bacin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012163:Retinal Detachment / Q000532:radiotherapy*; D012189:Retrospective Studies; D013997:Time Factors