title: Presence of spinal B7.2 (CD86) but not B7.1 (CD80) co-stimulatory molecules following peripheral nerve injury: role of nondestructive immunity in neuropathic pain.
abstract: Previous work in our laboratory demonstrated spinal neuroimmune activation and leukocyte trafficking into the central nervous system (CNS) parenchyma in a rat model of neuropathic pain. Recent studies suggest that co-stimulatory molecules B7.1 (CD80) and B7.2 (CD86) play a differential role in the effect of beneficial versus deleterious CNS autoimmune responses. In the present study, we determined the lumbar spinal expression of the co-stimulatory molecules B7.1 and B7.2 in a rat model of neuropathy. We observed intense B7.2 microglial immunoreactivity in the lumbar spinal cord following the injury but no expression of B7.1. These data suggest a role of protective CNS autoimmunity following peripheral nerve injury.
authors.affiliation: Department of Anesthesiology, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Rutkowski
authors.forename: F
authors.initials: F
authors.lastname: Lambert
authors.forename: V
authors.initials: V
authors.lastname: Raghavendra
authors.forename: J A
authors.initials: JA
authors.lastname: DeLeo
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis / Q000502:physiology*; D018122:B7-1 Antigen / Q000096:biosynthesis / Q000502:physiology*; D051940:B7-2 Antigen; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000502:physiology*; D010147:Pain Measurement / Q000379:methods; D010523:Peripheral Nervous System Diseases / Q000276:immunology / Q000378:metabolism*; D051381:Rats; D013116:Spinal Cord / Q000276:immunology / Q000378:metabolism; D013127:Spinal Nerves / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*
chemical_list: D015703:Antigens, CD; D018122:B7-1 Antigen; D051940:B7-2 Antigen; C497966:Cd86 protein, rat; D008562:Membrane Glycoproteins