[Dry eye disease as a complex dysregulation of the functional anatomy of the ocular surface. New concepts for understanding dry eye disease].
BACKGROUND
Dry eye disease is a disorder of the tear film that results in epithelial damage and in a disruption of the normal homeostasis at the ocular surface. It is widespread and causes symptoms ranging from discomfort to blindness.


METHODS
A review of the existing literature was used to compare different past and recent concepts for the understanding of dry eye disease with a focus on aspects of the integrating functional anatomy of the ocular surface.


RESULTS
The understanding of the pathogenesis of dry eye disease has proceeded from the mere recognition of a lack of tears to a consideration of their quality and to the concept of wetting of the ocular surface. However, several other aspects as epithelial differentiation, innervation, hormonal status or immune protection contribute to the intact functional anatomy of the ocular surface. Recently it has been recognized that immunologically regulated mechanisms of inflammation represent a primary or secondary pathogenetic factor for dry eye disease. This is conceivably regulated by the cells of the physiological mucosal immune defence system, the eye-associated lymphoid tissue (EALT). Androgens represent an important trophic factor for the ocular surface and their deficiency predisposes to inflammation.


CONCLUSIONS
Dry eye disease represents a complex dysregulation of the functional anatomy of the ocular surface that can start from different alterations (e.g. insufficient secretion, defects in wetting or innervation). Immune-based inflammation is able to interconnect and negatively reinforce these different pathomechanisms, resulting in a vicious circle.
Knop
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E
Augenklinik-Forschungslabor, Charité-Universitätsmedizin Berlin, Campus Virchow Klinikum. erich.knop@charite.de
Knop
N
N
Brewitt
H
H
D003228:Conjunctiva / Q000473:pathology / Q000503:physiopathology; D003315:Cornea / Q000473:pathology* / Q000503:physiopathology*; D015352:Dry Eye Syndromes / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D007765:Lacrimal Apparatus / Q000473:pathology* / Q000503:physiopathology*; D013666:Tears / Q000378:metabolism*