Defective activation-induced cell death in NOD T lymphocytes: 1,25-dihydroxyvitamin D3 restores defect.
The aim of this study was first to analyze strain differences in apoptosis resistance of NOD peripheral T lymphocytes in in vitro models of death by neglect and activation-induced cell death (AICD). Especially AICD is known to play a key role in peripheral tolerance, keeping autoimmune effector cells under control. Second, we studied the effects of in vivo treatment of NOD mice with 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], an immunomodulator known to prevent diabetes and insulitis in NOD mice, on in vitro T lymphocyte apoptosis resistance.
Decallonne
B
B
Laboratorium voor Experimentele Geneeskunde en Endocrinologie (LEGENDO), Katholieke Universiteit Leuven, Leuven, Belgium.
Mathieu
C
C
D000818:Animals; D002117:Calcitriol / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects / Q000276:immunology*; D005260:Female; D008213:Lymphocyte Activation; D051379:Mice; D016688:Mice, Inbred NOD; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*
D002117:Calcitriol