[Chinese traditional medicine yi kang ling to treat immunity infertility caused by anti-sperm antibody: the experimental research. I].
OBJECTIVE
To observe the effects of Chinese traditional medicine Yi Kang Ling (YKL) on immunity infertility caused by anti-sperm antibodies (AsAb).


METHODS
Based on the animal model of immunity infertility, seventy-five pairs of New Zealand rabbits were divided into three groups: YKL treatment group (sub-divided into mini-, midi- and maxi-dosage groups), prednisone treatment group and non-treatment group. Five pairs of normal rabbits were used as control. The AsAb from the rabbit serum were detected on the 15th, 30th and 45th day of treatment respectively. The sperm density, activity, the mobility and AsAb of seminal plasma from the obedient rabbits were determined.


RESULTS
Statistics showed that on the 45th day in mini- and maxi-YKL and prednisone treatment groups the positive serum AsAb reversing ratio reached 100%, and the seminal plasma AsAb reversing ratios were 85% in mini- and maxi-YKL group, 83% in midi-YKL and prednisone groups, while in non-treatment group the reversing ratios of the positive serum AsAb and seminal plasma AsAb were only 20% and 25% respectively. There were also remarkable differences (P < 0.05) in both serum AsAb and seminal plasma AsAb on the 45th day of treatment between YKL, prednisone treatment groups and the non-treatment group.


CONCLUSIONS
YKL can effectively reverse the AsAb positive results, hence increasing sperm mobility and improving sperm quality.
Cui
Ying-Xia
YX
Laboratory of Reproduction & Genetics, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China.
Huang
Yu-Feng
YF
Wang
Yong-Mei
YM
Hu
Yu-An
YA
Xu
Jian-Ping
JP
Yao
Bing
B
Fang
Rong
R
D000818:Animals; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D007246:Infertility / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D008517:Phytotherapy; D011817:Rabbits; D013094:Spermatozoa / Q000276:immunology*
D001323:Autoantibodies; D004365:Drugs, Chinese Herbal