[Granulosa cell tumor in different periods of women's life].
Ovarian granulosa cell tumor is uncommon malignancies. By virtue of histopathological examination we distinguish two subtype of GCT: adult type granulosa cell tumor typically in older women and juvenile granulosa cell tumor recognized primarily in children and young adults. GCTs behave unpredictably. Depending on histological type patients suffer recurrences in different time after treatment, even many years from diagnosis.


OBJECTIVE
The aim of our study is clinical analysis of patients with AGCT and JGCT, especially the problem of choice of treatment, time to occurring recurrences and new possibility in long term follow up.


METHODS
We analyzed 22 patients treated in Department of Gynecological Surgery and Oncology of Adults and Adolescent Pomeranian Academy of Medicine and then observed in our outpatient clinic.


RESULTS
Among analyzed 22 patients 18 had adult type of granulosa cell tumor, mean age of these women was 47 years (32-72). Juvenile type of granulosa cell tumor were recognized in 4 patients and they were from 4 to 7 years old. All young girls were underwent sparing surgery, one of them was treated with radiotherapy. In histopathological examination of 4 years old girl atypia and a lot of mitosis was observed and she was treated with chemotherapy. Unfortunately after 18 months from diagnosis she died due to very dynamic recurrence. Remained 3 girls live without evidence of disease and the longest time of follow up is 36 years. 16 women with AGCT were underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy and omentectomy, 2 were performed conservative surgery because they wish to preserve their fertility. 16 patients were treated with radiotherapy as an adjuvant treatment, two additionally with GnRH analogues. Recurrences in patients with AGCT were recognized in 5 cases. Mean time to recurrence from diagnosis were 11.7 years. In two patients it happened after 21 and 22 years. Despite of aggressive chemotherapy four of these patients died during one year. Remained 13 women with adult granulosa cell tumours live without evidence of disease and the longest time of observation is 9 years. In histopathological examination of all patients who died were describe cellular atypia and high mitotic rates. During long time follow up our patients were performed second-look laparoscopies, tested of estradiol levels and 5 of them also inhibin B levels which always correlated with actual condition.


CONCLUSIONS
Granulosa cell tumor is ovarian neoplasm of different behaviour. Patients with this diagnosis should be monitoring for many years. Inhibin is valuable examination in long term follow up.
Chudecka-Głaz
Anita
A
Rzepka-Górska
Izabella
I
Błogowska
Anna
A
Zielińska
Dorota
D
D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006106:Granulosa Cell Tumor / Q000097:blood / Q000473:pathology* / Q000601:surgery* / Q000628:therapy; D006801:Humans; D007044:Hysterectomy; D007265:Inhibins / Q000097:blood; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery* / Q000628:therapy; D011044:Poland; D012008:Recurrence; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
D007265:Inhibins