title: Differential associations between entorhinal and hippocampal volumes and memory performance in older adults.
abstract: Magnetic resonance imaging-derived entorhinal and hippocampal volumes were measured in 14 nondemented, community-dwelling older adults. Participants were selected so that memory scores from 2 years prior to scanning varied widely but were not deficient relative to age-appropriate norms. A median split of these memory scores defined high-memory and low-memory groups. Verbal memory scores at the time of imaging were lower, and entorhinal and hippocampal volumes were smaller, in the low-memory group than in the high-memory group. Left entorhinal cortex volume showed the strongest correlation (r= .79) with immediate recall of word lists. Left hippocampal volume showed the strongest correlation (r= .57) with delayed paragraph recall. These results suggest that entorhinal and hippocampal volumes are related to individual differences in dissociable kinds of memory performance among healthy older adults.
authors.affiliation: Department of Psychology, Stanford University, Stanford, California 94305, USA. rosena@psych.stanford.edu
authors.forename: Allyson C
authors.initials: AC
authors.lastname: Rosen
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Prull
authors.forename: John D E
authors.initials: JD
authors.lastname: Gabrieli
authors.forename: Travis
authors.initials: T
authors.lastname: Stoub
authors.forename: Ruth
authors.initials: R
authors.lastname: O'Hara
authors.forename: Leah
authors.initials: L
authors.lastname: Friedman
authors.forename: Jerome A
authors.initials: JA
authors.lastname: Yesavage
authors.forename: Leyla
authors.initials: L
authors.lastname: deToledo-Morrell
mesh_terms: D000368:Aged; D001931:Brain Mapping; D018728:Entorhinal Cortex / Q000033:anatomy & histology / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006624:Hippocampus / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009929:Organ Size; D012016:Reference Values; D013223:Statistics as Topic; D014706:Verbal Learning / Q000502:physiology*