title: Management of recurrence and follow-up strategies for patients with seminoma and selected high-risk groups.
abstract: Seminoma is characterized by high sensitivity to both radiation and chemotherapy. Localized recurrences in the retroperitoneum after surveillance for stage I can be treated with radiotherapy; however, multiple or large bulky retroperitoneal recurrences or systemic metastasis requires cisplatin-based chemotherapy. Salvage chemotherapy for those who recur after initial CR to induction chemotherapy is based on ifosfamide- and cisplatin-containing regimens. Incomplete response or failure after induction chemotherapy requires high-dose chemotherapy and stem cell rescue. Patients with seminoma need long-term follow-up because of the possibility of late recurrence and the risk of a second primary tumor.
authors.affiliation: Department of Urology, Memorial Sloan-Kettering Cancer Center, 353 E. 68th Street, New York, NY 10021, USA.
authors.forename: Manish I
authors.initials: MI
authors.lastname: Patel
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Motzer
authors.forename: Joel
authors.initials: J
authors.lastname: Sheinfeld
mesh_terms: D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D012008:Recurrence; D018239:Seminoma / Q000628:therapy*; D013736:Testicular Neoplasms / Q000628:therapy*