Magnetic resonance imaging of the ischaemic penumbra.
Acute cerebral ischaemia should no longer be considered a tragic untreatable event but a medical emergency. To be able to start therapy, imaging is needed to assess the presence of a potential penumbra, i.e. an area of the brain which is hypoperfused but not yet definitively infarcted. With the development of diffusion and perfusion MR techniques, the concept of a penumbra model has been developed in which it corresponds to the acute mismatch between diffusion and perfusion volumes. This penumbra should constitute the target for potential therapies.
Lövblad
Karl-Olof
KO
Department of Neuroradiology, Inselspital, University of Bern, Switzerland. Karl-Olof.Lovblad@hcuge.ch
El-Koussy
Marwan
M
Oswald
Helmut
H
Baird
Alison E
AE
Schroth
Gerhard
G
Mattle
Heinrich
H
D002545:Brain Ischemia / Q000188:drug therapy / Q000473:pathology*; D003287:Contrast Media; D006801:Humans; D007261:Infusions, Intra-Arterial; D008279:Magnetic Resonance Imaging / Q000379:methods*; D020521:Stroke / Q000188:drug therapy / Q000473:pathology*; D015912:Thrombolytic Therapy
D003287:Contrast Media