title: The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens.
abstract: Microbial pathogens use a variety of their surface molecules to bind to host extracellular matrix (ECM) components to establish an effective infection. However, ECM components can also serve as an integral part of the innate immunity. Mice lacking expression of mindin (spondin 2), a highly conserved ECM protein, have an impaired ability to clear bacterial infection, and mindin-deficient macrophages show defective responses to a broad spectrum of microbial stimuli. Moreover, mindin binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Thus, mindin is essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens.
authors.affiliation: Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA. he000004@mc.duke.edu
authors.forename: You-Wen
authors.initials: YW
authors.lastname: He
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Chia-Lin
authors.initials: CL
authors.lastname: Hsu
authors.forename: Emily
authors.initials: E
authors.lastname: Lin
authors.forename: Nu
authors.initials: N
authors.lastname: Zhang
authors.forename: Jian
authors.initials: J
authors.lastname: Guo
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Forbush
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bevan
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D005109:Extracellular Matrix / Q000276:immunology*; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000276:immunology*; D005260:Female; D006090:Gram-Negative Bacteria / Q000276:immunology* / Q000472:pathogenicity; D016905:Gram-Negative Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D006094:Gram-Positive Bacteria / Q000276:immunology* / Q000472:pathogenicity; D016908:Gram-Positive Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000276:immunology / Q000382:microbiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D013682:Teichoic Acids / Q000276:immunology
chemical_list: D016207:Cytokines; D016326:Extracellular Matrix Proteins; D008070:Lipopolysaccharides; D013682:Teichoic Acids; C121491:mindin; C009900:lipoteichoic acid