title: Macrophage infiltration of pancreatic acini and islets in acute Kawasaki disease.
abstract: A report of 2 patients who developed diabetes after Kawasaki disease (KD) led us to determine whether macrophages and/or T cells infiltrate acute KD pancreas. Three of 10 acute fatal KD cases had diffuse macrophage infiltration of the pancreas; T cells were not prominent. Affected islets were seen in close proximity to normal islets. These findings may explain the rarity of diabetes after KD.
authors.affiliation: Department of Pediatrics, Northwestern University, Chicago, IL 60611, USA. miura@as.email.ne.jp
authors.forename: Masaru
authors.initials: M
authors.lastname: Miura
authors.forename: Francesca
authors.initials: F
authors.lastname: Garcia
authors.forename: Susan E
authors.initials: SE
authors.lastname: Crawford
authors.forename: Anne H
authors.initials: AH
authors.lastname: Rowley
mesh_terms: D000208:Acute Disease; D001707:Biopsy, Needle; D016022:Case-Control Studies; D046508:Culture Techniques; D003920:Diabetes Mellitus / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000276:immunology / Q000473:pathology*; D008264:Macrophages / Q000276:immunology* / Q000473:pathology; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications* / Q000276:immunology / Q000473:pathology*; D011379:Prognosis; D012016:Reference Values; D012680:Sensitivity and Specificity