Natural product-like and other biologically active heterocyclic libraries using solid-phase techniques in the post-genomic era.
High-throughput technologies allow the selection of new biological targets for drug discovery in the post-genomic era. These tools increase the need of new methods to rapidly obtain potent small molecules and natural products to discover new lead structures. In particular, the solid-phase synthesis offers a great potential to obtain large compound sets.
Knepper
K
K
Kekulé-Institut für Organische Chemie und Biochemie der Rheinischen, Friedrich-Wilhelms-Universität Bonn, Gerhard-Domagk-Strasse 1, D-53121 Bonn, Germany.
Gil
C
C
Bräse
S
S
D020650:Combinatorial Chemistry Techniques; D004353:Drug Evaluation, Preclinical / Q000379:methods; D023281:Genomics; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
D006571:Heterocyclic Compounds