title: Assessment of olfactory function and androstenone odor thresholds in humans with or without functional occlusion of the vomeronasal duct.
abstract: To obtain information on the possible role of the vomeronasal duct (VND) in odor perception and human pheromone detection, the present study investigated different aspects of olfactory function, including thresholds for androstenone in adults with or without detectable VNDs. The study also examined correlations between detection thresholds of androstenone odor and general olfactory function. Subjects' olfaction was assessed with tests for odor identification, odor discrimination, and phenyl ethyl alcohol odor threshold. Measurements were performed on 1 side only, with and without covering the VND. Subjects with or without detectable VNDs did not differ in olfactory sensitivity or androstenone odor thresholds. A small but significant correlation was found between detection thresholds of androstenone and general olfactory function. Finally, covering of the VND did not affect olfactory function or androstenone sensitivity. Results suggest that the human VND does not play a major role in sensitivity toward odorants or the perception of androstenone.
authors.affiliation: Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Knecht
authors.forename: Johan N
authors.initials: JN
authors.lastname: Lundström
authors.forename: Martin
authors.initials: M
authors.lastname: Witt
authors.forename: Karl-Bernd
authors.initials: KB
authors.lastname: Hüttenbrink
authors.forename: Stefan
authors.initials: S
authors.lastname: Heilmann
authors.forename: Thomas
authors.initials: T
authors.lastname: Hummel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000738:Androsterone / Q000502:physiology*; D003251:Constriction, Pathologic / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009812:Odorants; D000857:Olfaction Disorders / Q000503:physiopathology*; D010465:Perception / Q000187:drug effects / Q000502:physiology; D010675:Pheromones / Q000494:pharmacology; D012684:Sensory Thresholds / Q000187:drug effects / Q000502:physiology; D012903:Smell / Q000502:physiology*; D019147:Vomeronasal Organ / Q000187:drug effects / Q000502:physiology*
chemical_list: D010675:Pheromones; D000738:Androsterone