title: Vitamin E-coated membrane dialyzer and beta2-microglobulin removal.
abstract: This study was designed to test the removal of beta2-microglobulin (beta2M) in a vitamin E-modified membrane. We investigated in vivo the dialyzer (Excebrane, series EE, 1.8 m2) with respect to hydraulic permeability (Kuf), maximum ultrafiltration rate (UF max), sieving coefficient (Sc), and solute clearances in hemodialysis (HD) and in soft hemodiafiltration (HDF). Kuf was 18.4 ml/h/mmHg, UF max was 75 ml/min, and Sc for beta2M was 0.45. Clearance values at 400 ml/min of Qb in HD were 258 ml/min for urea, 201 ml/min for creatinine, and 135 ml/min for phosphate. In soft HDF, clearances were slightly higher. beta2M clearance was 26 ml/min in HD and 43 ml/min in soft HDF. In conclusion, Excebrane (series EE) procures a soft HDF with an amount of substitution fluid in post dilution mode of over 60 ml/min. Remarkable small solute clearances were obtained when the blood flow was raised to 400 ml/min. A significant reduction of beta2M is demonstrated by HDF.
authors.affiliation: Renal Unit, Ospedale Maggiore, Lodi, Italy. nefrodialisilodi@pmp.it
authors.forename: S
authors.initials: S
authors.lastname: Mandolfo
authors.forename: R
authors.initials: R
authors.lastname: Bucci
authors.forename: E
authors.initials: E
authors.lastname: Imbasciati
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D001696:Biomechanical Phenomena; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D017583:Hemodiafiltration / Q000295:instrumentation; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008567:Membranes, Artificial; D008875:Middle Aged; D006435:Renal Dialysis / Q000295:instrumentation*; D014810:Vitamin E / Q000494:pharmacology*; D001613:beta 2-Microglobulin / Q000097:blood / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D020099:Coated Materials, Biocompatible; D008567:Membranes, Artificial; D001613:beta 2-Microglobulin; D014810:Vitamin E