Frequency, clinical presentation and evolution of renal oncocytomas: multicentric experience from a European database.
OBJECTIVE
To understand the clinical behavior of renal oncocytoma in a retrospective analysis of a European multicentric nephrectomies database.


METHODS
The records of 891 patients who underwent surgical resection of renal neoplasm were reviewed. Relevant clinical and pathological data for each patient were retrieved in a database.


RESULTS
Thirty-two (3.6%) cases of renal oncocytoma were identified. Twenty patients (62.5%) were asymptomatic. No case of lymphatic invasion or metastatic disease, nor any evidence of vascular or fat tissue invasion was found. Thirty-one cases (96%) exhibited low mitotic activity. In one case the presence of renal clear cell carcinoma (diameter: 1.5cm) was found. After a median follow-up of 42 months, 87.5% of patients were alive with no evidence of tumor, while 9.3% of patients had died for non-malignant causes. One patient had not treated the tumor surgically and was disease-free at a 27-month follow-up.


CONCLUSIONS
Renal oncocytoma is a benign neoplasm, characterized by slow growth and excellent prognosis after surgery. Nephron sparing techniques may be adequate for tumor removal.
Romis
Leo
L
Department of Urology, Medical School of University "Federico II", Naples, Italy. lucacindolo@virgilio.it
Cindolo
Luca
L
Patard
Jean Jacques
JJ
Messina
Giovanni
G
Altieri
Vincenzo
V
Salomon
Laurent
L
Abbou
Claude Clement
CC
Chopin
Dominique
D
Lobel
Bernard
B
de La Taille
Alexandre
A
D018262:Adenocarcinoma, Clear Cell / Q000175:diagnosis / Q000453:epidemiology; D018249:Adenoma, Oxyphilic / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery*; D000328:Adult; D000368:Aged; D016208:Databases, Factual; D005060:Europe; D005260:Female; D006801:Humans; D015994:Incidence; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies