Effect of methoxime combined with anticholinergic, anticonvulsant or anti-HCN drugs in tabun-poisoned mice.
The effect of methoxime combined with a) atropine, b) benactyzine, c) atropine and natrium thiosulphate, d) atropine and diazepam on antidotal treatment effectiveness was studied in tabun-poisoned mice. In addition, the influence of pretreatment consisiting of pyridostigmine, benactyzine and trihexyphenidyle (PANPAL) administered 2 hours before tabun intoxication on the treatment effectivity of methoxime combined with e) atropine or f) benactyzine was tested. The most efficacious therapeutic mixture in non-pretreated mice was methoxime, atropine and diazepam. Natrium thiosulphate did not significantly increase neither decrease the antidotal treatment efficacy in comparison with methoxime and atropine alone. Pretreatment with PANPAL significantly decreased tabun toxicity (nearly 4 times in methoxime and benactyzine combination and more than 4 times in atropine and methoxime mixture). The present study demonstrates that the tabun toxicity in mice is more effectively reduced when PANPAL prophylactically is administered than in case of treatment with methoxime and cholinergic drug alone. We established that anticholinergic drug option in the therapeutic mixture of methoxime and anticholinergic drug did not cause the difference in the antidotal treatment effectivities.
Sevelová
Lucie
L
Department of Toxicology, Purkynĕ Military Medical Academy, Hradec Králové, Czech Republic. sevelova@pmfhk.cz
Vachek
Josef
J
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage*; D000931:Antidotes / Q000008:administration & dosage*; D001535:Benactyzine / Q000008:administration & dosage; D002619:Chemical Warfare Agents / Q000506:poisoning*; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D051379:Mice; D062025:Organophosphate Poisoning; D010755:Organophosphates; D010091:Oximes / Q000008:administration & dosage*; D011292:Premedication; D011729:Pyridostigmine Bromide / Q000008:administration & dosage; D013885:Thiosulfates / Q000008:administration & dosage*; D014282:Trihexyphenidyl / Q000008:administration & dosage
D000927:Anticonvulsants; D000931:Antidotes; D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D004338:Drug Combinations; D010755:Organophosphates; D010091:Oximes; D013885:Thiosulfates; C416025:panpal; D001535:Benactyzine; C005514:N,N'-monomethylenebis(pyridiniumaldoxime); D014282:Trihexyphenidyl; C017717:sodium thiosulfate; D011729:Pyridostigmine Bromide; C009374:tabun