title: NKT cell frequency in Japanese type 1 diabetes.
abstract: A numerical and functional deficit of natural killer T (NKT) cells has been reported to be associated with the pathogenesis of Caucasian patients with type 1 diabetes. However, a conflicting finding of a higher frequency of NKT cells (Valpha24+ Vbeta11+ T cells) was observed in islet-associated Ab+ and Ab- Japanese "classic" type 1 diabetes. Here, we combined the data of NKT cell frequency in Ab+ and Ab- "classic" type 1 diabetic patients and then analyzed the relationship between NKT cell frequency and disease activity.
authors.affiliation: Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan. y-oikawa@mvc.biglobe.ne.jp
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Oikawa
authors.forename: Akira
authors.initials: A
authors.lastname: Shimada
authors.forename: Satoru
authors.initials: S
authors.lastname: Yamada
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Motohashi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Jun-Ichiro
authors.initials: J
authors.lastname: Irie
authors.forename: Taro
authors.initials: T
authors.lastname: Maruyama
authors.forename: Takao
authors.initials: T
authors.lastname: Saruta
mesh_terms: D000293:Adolescent; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007564:Japan; D007694:Killer Cells, Natural / Q000276:immunology*; D008297:Male; D008875:Middle Aged
chemical_list: D006442:Glycated Hemoglobin