Peptide deformylase inhibitors with activity against respiratory tract pathogens.
A series of analogues of the peptide deformylase (PDF) inhibitor BB-3497 where the P3' amide bond was replaced with a ketone functionality is described. The in vitro antibacterial profiling of these compounds revealed that they demonstrate activity against pathogens associated with respiratory tract infections.
East
Stephen P
SP
British Biotech Pharmaceuticals Limited, Watlington Road, Oxford OX4 6LY, UK. stephen.east@evotecoai.com
Beckett
R Paul
RP
Brookings
Daniel C
DC
Clements
John M
JM
Doel
Sheila
S
Keavey
Kenneth
K
Pain
Gilles
G
Smith
Helen K
HK
Thomas
Wayne
W
Thompson
Alison J
AJ
Todd
Richard S
RS
Whittaker
Mark
M
D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use; D006193:Haemophilus influenzae / Q000187:drug effects / Q000201:enzymology; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D001936:Moraxella catarrhalis / Q000187:drug effects / Q000201:enzymology; D012141:Respiratory Tract Infections / Q000201:enzymology* / Q000382:microbiology*; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000201:enzymology
D000890:Anti-Infective Agents; D004791:Enzyme Inhibitors; D000581:Amidohydrolases; C084507:peptide deformylase