The possibility of using mifepristone for menstrual induction.
Menstrual induction is a variant of suction aspiration that was originally defined to be performed in women with a menstrual delay of up to 2-3 weeks without knowing if the women is pregnant or not. Prerequisites for a pharmacological method for menstrual induction are a high efficacy to induce a bleeding in nonpregnant women and an expulsion of the pregnancy in pregnant women. Treatment with prostaglandins, specifically intramuscular sulprostone, can be as effective as suction aspiration for menstrual induction. However, the administration of prostaglandin in therapeutically effective doses was associated with a high frequency of gastrointestinal side effects and, to a lesser extent, of strong abdominal pain, which limited their routine use. More recent studies indicate that mifepristone in combination with either misoprostol or gemeprost is a more promising alternative. Further studies to identify the best treatment schedule are, however, needed, as is a randomized comparison with suction aspiration before a pharmaceutical method can be recommended.
Bygdeman
Marc
M
Department of Woman and Child Health, Division for Obstetrics and Gynecology, Karolinska Hospital, S-171 76, Stockholm, Sweden. bygdeman@privat.utfors.se
D000328:Adult; D003276:Contraceptives, Oral / Q000494:pharmacology; D003283:Contraceptives, Postcoital, Synthetic / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008598:Menstruation / Q000187:drug effects*; D008600:Menstruation-Inducing Agents / Q000494:pharmacology*; D015735:Mifepristone / Q000494:pharmacology*
D003276:Contraceptives, Oral; D003283:Contraceptives, Postcoital, Synthetic; D008600:Menstruation-Inducing Agents; D015735:Mifepristone