[Regulation of cardiac functions by the L-arginine--nitric oxide system].
It is shown that intracoronary infusion of L-arginine and sodium nitroprusside induces an increase in coronary flow (CF), myocardial contractility (MC) and heart rate (HR) in the isolated perfused heart of the rat. Three combinations of these effects have been observed in different experiments: generalized effect (increase of CF + MC + HR), a double effect in three variants (increase of CF + MC, CF + HR, MC + HR) and isolated effect (increase of CF or MC or HR). The data obtained suggest that an increase of CF is the main change induced by L-arginine in the isolated perfused heart, an increase of MC being secondary in relation to a CF increase, i.e. an increase of CF mediates an increase of MC (Gregg's phenomenon). A positive inotropic effect of sodium nitroprusside is the result mainly of its direct action on the myocardium and to a lesser extent due to a CF increase.
Markov
Kh M
KhM
Nadirashvili
S A
SA
D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects*; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D009569:Nitric Oxide / Q000502:physiology*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D009599:Nitroprusside / Q000494:pharmacology; D051381:Rats
D020030:Nitric Oxide Donors; D009599:Nitroprusside; D009569:Nitric Oxide; D001120:Arginine