Study of the relationship of small variations of the molecular structure and the iron state in iron containing proteins by Mössbauer spectroscopy: biomedical approach.
This review considers the results of experimental Mössbauer studies and theoretical calculations of the effect of small variations of protein molecular structure on the iron electronic structure and stereochemistry in order to understand the proteins structural heterogeneity and functional variety. Structural changes in iron containing proteins during various diseases are also considered. These results show the relationship of the small structural variations and Mössbauer parameters of iron containing proteins and demonstrate the possibilities of Mössbauer spectroscopy to obtain new information at the molecular level in biomedical research.
Oshtrakh
M I
MI
Division of Applied Biophysics, Faculty of Physical Techniques and Devices for Quality Control, Ural State Technical University, Ekaterinburg 620002, Russian Federation. oshtrakh@mail.utnet.ru
D000818:Animals; D005293:Ferritins / Q000737:chemistry*; D006418:Heme / Q000737:chemistry; D006454:Hemoglobins / Q000737:chemistry*; D006801:Humans; D007501:Iron / Q000737:chemistry*; D008956:Models, Chemical; D008958:Models, Molecular; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D015204:Spectroscopy, Mossbauer / Q000379:methods*; D013237:Stereoisomerism
D006454:Hemoglobins; D006418:Heme; D005293:Ferritins; D007501:Iron