title: Compositional biases and polyalanine runs in humans.
abstract: Human proteins containing polyalanine tracts tend to have runs of other amino acids and their open reading frames (ORFs) display a biased codon usage. Their alanine, glycine, proline, and histidine content strongly correlates with the GC content of the third codon base, suggesting that the compositional specificity of these proteins is dictated to a great extent by the evolution of their ORFs.
authors.affiliation: INSERM E0021 and U361, Reproduction et Physiopathologie Obstétricale, Hôpital Cochin, 75014 Paris, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Cocquet
authors.forename: Elfride
authors.initials: E
authors.lastname: De Baere
authors.forename: Sandrine
authors.initials: S
authors.lastname: Caburet
authors.forename: Reiner A
authors.initials: RA
authors.lastname: Veitia
mesh_terms: D003062:Codon; D006801:Humans; D016366:Open Reading Frames; D010455:Peptides / Q000235:genetics*
chemical_list: D003062:Codon; D010455:Peptides; C019529:polyalanine