title: Solid-phase synthesis of structurally diverse scaffolded peptides for the mimicry of discontinuous protein binding sites.
abstract: Scaffolded peptides, in which fragments of the sequence are presented through a molecular scaffold in a discontinuous and nonlinear fashion, are promising candidates for the mimicry of discontinuous protein binding sites. Twelve scaffold molecules based on cyclic peptides with ring sizes ranging from 13 to 30 were generated. Up to three different peptide fragments were attached to the scaffolds in a site-selective manner, yielding scaffolded peptides in excellent purities, as documented by MS, HPLC, and 2D (1)H NMR spectroscopy data.
authors.affiliation: GBF - German Research Centre for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany.
authors.forename: Raimo
authors.initials: R
authors.lastname: Franke
authors.forename: Christian
authors.initials: C
authors.lastname: Doll
authors.forename: Victor
authors.initials: V
authors.lastname: Wray
authors.forename: Jutta
authors.initials: J
authors.lastname: Eichler
mesh_terms: D001565:Benzoates / Q000737:chemistry; D001665:Binding Sites; D002851:Chromatography, High Pressure Liquid; D019281:Dimerization; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D018716:Molecular Mimicry; D010446:Peptide Fragments / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis*; D010456:Peptides, Cyclic / Q000737:chemistry; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*
chemical_list: D001565:Benzoates; D010446:Peptide Fragments; D010455:Peptides; D010456:Peptides, Cyclic; D011506:Proteins