title: Curvularia--favorable response to oral itraconazole therapy in two patients with locally invasive phaeohyphomycosis.
abstract: Curvularia species are ubiquitous and occasionally lead to infections in humans. In immunosuppressed patients, infections are often serious, and systemic dissemination is not uncommon. The optimal antifungal therapy is unclear. I here present two cases, a healthy man with locally invasive, mulicentric paranasal fungal sinusitis, and a case of progressive verrucal distal onychomycosis that developed while the patient was undergoing accelerated chemotherapy for non-Hodgkin's lymphoma. Both patients showed excellent responses to treatment with itraconazole suspension. Oral itraconazole may provide a safe and effective alternative for patients with locally invasive non-disseminated mycoses due to Curvularia species.
authors.affiliation: Department of Infectious Diseases, Infection Control and Employee Health, 402, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030-4095, USA. asafdar@mdanderson.org
authors.forename: A
authors.initials: A
authors.lastname: Safdar
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001203:Ascomycota / Q000254:growth & development*; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy*; D014009:Onychomycosis / Q000188:drug therapy / Q000382:microbiology; D012852:Sinusitis / Q000188:drug therapy / Q000382:microbiology
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole