In vitro activities of DA-7867, a novel oxazolidinone, against recent clinical isolates of aerobic and anaerobic bacteria.
In vitro activities of DA-7867, a novel oxazolidinone, were compared to those of linezolid and commonly used antimicrobials. DA-7867 had the lowest MIC for 90% of the aerobic gram-positive bacterial strains tested, </=0.25 micro g/ml, and it was more potent than linezolid.
Yong
Dongeun
D
Department of Laboratory Medicine, Research Institute of Bacterial Resistance, and Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Yum
Jong Hwa
JH
Lee
Kyungwon
K
Chong
Yunsop
Y
Choi
Sung Hak
SH
Rhee
Jae Keol
JK
D000081:Acetamides / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001420:Bacteria, Aerobic / Q000187:drug effects*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D001424:Bacterial Infections / Q000382:microbiology*; D001439:Bacteroides / Q000187:drug effects; D024881:Drug Resistance, Bacterial; D013293:Enterococcus faecalis / Q000187:drug effects; D016984:Enterococcus faecium / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D000069349:Linezolid; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects; D020713:Vancomycin Resistance
D000081:Acetamides; D000890:Anti-Infective Agents; C480487:DA-7867; D023303:Oxazolidinones; D000069349:Linezolid