Involvement of Rel/NF-kappa B transcription factors in senescence.
Senescence is now established as a genetically controlled phenomenon that alters different cell functions, including proliferation, apoptosis, resistance to stress, and energetic metabolism. Underlying changes in gene expression are governed by some transcription factors, whose expression or activity must change with senescence as well. Transcription factors of the Rel/NF-kappa B family are good candidates to participate in the establishment of senescence. Arguments range from correlation between cell functions controlled by these factors and cell functions altered during senescence, to phenotypes resulting from in vitro manipulations of Rel/NF-kappa B activity.
Gosselin
Karo
K
UMR 8117 CNRS-Institut Pasteur de Lille-Université Lille 1, Institut de Biologie de Lille, 1 rue Calmette, BP 447, 59021 Lille Cedex, France.
Abbadie
Corinne
C
D000375:Aging / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D016922:Cellular Senescence / Q000235:genetics; D006801:Humans; D016328:NF-kappa B / Q000235:genetics*; D020569:Proto-Oncogene Proteins c-rel / Q000235:genetics*; D014157:Transcription Factors / Q000502:physiology*
D016328:NF-kappa B; D020569:Proto-Oncogene Proteins c-rel; D014157:Transcription Factors