A simple effective method for estimating the [18O] enrichment of water mixtures.
Isotopically enriched water, [18O] H(2)O, recovered from the synthesis of [18F] fluorine-labelled PET radiopharmaceuticals, is frequently diluted with natural water, [16O] H(2)O. The extent of isotope dilution limits the usefulness of the recovered water. A simple method for determining the [18O] enrichment of water mixtures could aid PET cyclotron facilities to calculate the [18F] yields to be expected when the recovered [18O] H(2)O is reused. A gravimetric method (repeatability for high enrichment +/-0.3% [18O], detection limit approximately 2% [18O] enrichment) is described.
Fawdry
Richard M
RM
PET & Nuclear Medicine, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia. rfawdry@nucmed.rpa.nsw.gov.au
D005462:Fluorine Radioisotopes; D007220:Industrial Waste / Q000517:prevention & control; D010104:Oxygen Radioisotopes / Q000032:analysis / Q000302:isolation & purification*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis; D014875:Water Pollutants, Radioactive / Q000032:analysis / Q000302:isolation & purification*
D005462:Fluorine Radioisotopes; D007220:Industrial Waste; D010104:Oxygen Radioisotopes; D019275:Radiopharmaceuticals; D014875:Water Pollutants, Radioactive