Herpes simplex virus infection and apoptosis.
Consequences of human herpes simplex virus (HSV) infection include the induction of apoptosis and the concomitant synthesis of proteins which act to block this process from killing the infected cell. Recent data has clarified our current understanding of the mechanisms of induction and prevention of apoptosis by HSV. These findings emphasize the fact that modulation of apoptosis by HSV during infection is a multicomponent phenomenon. We review recent evidence showing how this important human pathogen modulates the fundamental cell death process.
Goodkin
Margot L
ML
Department of Microbiology, Mount Sinai School of Medicine, New York, New York 10029, USA.
Morton
Elise R
ER
Blaho
John A
JA
D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000378:metabolism; D003588:Cytopathogenic Effect, Viral; D017353:Gene Deletion; D005814:Genes, Viral; D006561:Herpes Simplex / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D006801:Humans; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism; D015398:Signal Transduction; D018139:Simplexvirus / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology; D014764:Viral Proteins / Q000235:genetics / Q000502:physiology; D014779:Virus Replication
D016328:NF-kappa B; D014764:Viral Proteins; D020169:Caspases