High levels of SIVmnd-1 replication in chronically infected Mandrillus sphinx.
Viral loads were investigated in SIVmnd-1 chronically infected mandrills and the results were compared with those previously observed in other nonpathogenic natural SIV infections. Four naturally and 11 experimentally SIVmnd-1-infected mandrills from a semi-free-ranging colony were studied during the chronic phase of infection. Four SIVmnd-1-infected wild mandrills were also included for comparison. Twelve uninfected mandrills were used as controls. Viral loads in all chronically infected mandrills ranged from 10(5) to 9 x 10(5) copies/ml and antibody titers ranged from 200 to 14,400 and 200 to 12,800 for anti-V3 and anti-gp36, respectively. There were no differences between groups of wild and captive mandrills. Both parameters were stable during the follow-up, and no clinical signs of immune suppression were observed. Chronic SIVmnd-1-infected mandrills presented slight increases in CD20+ and CD28+/CD8+ cell counts, and a slight decrease in CD4+/CD3+ cell counts. A slight CD4+/CD3+ cell depletion was also observed in old uninfected controls. Similar to other nonpathogenic models of lentiviral infection, these results show a persistent high level of SIVmnd-1 replication during chronic infection of mandrills, with minimal effects on T cell subpopulations.
Pandrea
Ivona
I
Laboratoire de Virologie, UGENET, SEGC, Réserve de la Lopé, Centre de Primatologie, Centre International de Recherches Médicales, BP769, Franceville, Gabon, France.
Onanga
Richard
R
Kornfeld
Christopher
C
Rouquet
Pierre
P
Bourry
Olivier
O
Clifford
Stephen
S
Telfer
Paul T
PT
Abernethy
Kate
K
White
Lee T W
LT
Ngari
Paul
P
Müller-Trutwin
Michaela
M
Roques
Pierre
P
Marx
Preston A
PA
Simon
Francois
F
Apetrei
Cristian
C
D000818:Animals; D000835:Animals, Wild; D002908:Chronic Disease; D004195:Disease Models, Animal; D016131:Lymphocyte Subsets; D008992:Monkey Diseases / Q000821:virology*; D010215:Papio / Q000821:virology*; D012367:RNA, Viral / Q000097:blood; D016097:Simian Acquired Immunodeficiency Syndrome / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000472:pathogenicity* / Q000502:physiology; D019562:Viral Load; D014779:Virus Replication
D012367:RNA, Viral