title: Carotid arteries: contrast-enhanced US angiography--preliminary clinical experience.
abstract: B-mode ultrasonographic (US) angiography enhanced with a microbubble-based US contrast agent (FS069) was evaluated in human subjects with carotid artery disease. Results at contrast material-enhanced US angiography and duplex US were compared with those at conventional angiography. Both US angiography and duplex US accurately depicted stenoses of 70% or more compared with those depicted at conventional angiography. The percentage diameter stenosis of the internal carotid artery measured at US angiography strongly correlated with that measured at conventional angiography (r = 0.988). The percentage area stenosis measured at US angiography strongly correlated with ex vivo measurements of the resected carotid plaque at magnetic resonance imaging (r = 0.979). US angiography depicted unsuspected wall irregularities, ulceration, and dissection.
authors.affiliation: Department of Radiology, University of California, San Diego Medical Center, 200 W Arbor Dr, Dept 8756, San Diego, CA 92103-8756, USA. ykono@ucsd.edu
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kono
authors.forename: Sean P
authors.initials: SP
authors.lastname: Pinnell
authors.forename: Claude B
authors.initials: CB
authors.lastname: Sirlin
authors.forename: Steven R
authors.initials: SR
authors.lastname: Sparks
authors.forename: Bassem
authors.initials: B
authors.lastname: Georgy
authors.forename: Wade
authors.initials: W
authors.lastname: Wong
authors.forename: Robert F
authors.initials: RF
authors.lastname: Mattrey
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins; D000792:Angiography / Q000379:methods*; D001783:Blood Flow Velocity / Q000502:physiology; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging* / Q000601:surgery; D016893:Carotid Stenosis / Q000000981:diagnostic imaging* / Q000601:surgery; D003287:Contrast Media; D016894:Endarterectomy, Carotid; D005260:Female; D005466:Fluorocarbons; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D018616:Ultrasonography, Doppler, Duplex / Q000379:methods*
chemical_list: D000418:Albumins; D003287:Contrast Media; C099458:FS 069; D005466:Fluorocarbons