title: Bilateral nongranulomatous anterior uveitis associated with bimatoprost.
abstract: A 72-year-old man with long-standing bilateral glaucoma became refractory to levobunolol ophthalmic solution therapy after many years. Brimonidine was prescribed, but the patient developed a hypersensitivity several months later that was treated with loteprednol ophthalmic suspension. Bimatoprost was initiated 2 weeks later. Within an hour of the first dose of bimatoprost, the patient reported eye pain and photophobia that remained unresolved the following day. Examination revealed acute bilateral nongranulomatous anterior uveitis that was effectively treated with loteprednol. While observations in human and animal models suggest an association between certain prostaglandin-like agents and intraocular inflammation, this report is one of the first to suggest a link between bimatoprost and intraocular inflammatory reaction.
authors.affiliation: Casey Eye Institute, Department of Ophthalmology, Oregon Health and Science University, Portland, OR 97401, USA. mpacker@finemd.com
authors.forename: Mark
authors.initials: M
authors.lastname: Packer
authors.forename: I Howard
authors.initials: IH
authors.lastname: Fine
authors.forename: Richard S
authors.initials: RS
authors.lastname: Hoffman
mesh_terms: D000368:Aged; D000577:Amides; D000959:Antihypertensive Agents / Q000009:adverse effects*; D000069580:Bimatoprost; D003008:Cloprostenol / Q000031:analogs & derivatives; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D007429:Intraocular Pressure; D008055:Lipids / Q000009:adverse effects*; D008297:Male; D014606:Uveitis, Anterior / Q000139:chemically induced*; D014792:Visual Acuity
chemical_list: D000577:Amides; D000959:Antihypertensive Agents; D008055:Lipids; D003008:Cloprostenol; D000069580:Bimatoprost