title: Dual activation of the Drosophila toll pathway by two pattern recognition receptors.
abstract: The Toll-dependent defense against Gram-positive bacterial infections in Drosophila is mediated through the peptidoglycan recognition protein SA (PGRP-SA). A mutation termed osiris disrupts the Gram-negative binding protein 1 (GNBP1) gene and leads to compromised survival of mutant flies after Gram-positive infections, but not after fungal or Gram-negative bacterial challenge. Our results demonstrate that GNBP1 and PGRP-SA can jointly activate the Toll pathway. The potential for a combination of distinct proteins to mediate detection of infectious nonself in the fly will refine the concept of pattern recognition in insects.
authors.affiliation: Unité Propre de Recherche 9022 du CNRS, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, F67084 Strasbourg Cedex, France.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Gobert
authors.forename: Marie
authors.initials: M
authors.lastname: Gottar
authors.forename: Alexey A
authors.initials: AA
authors.lastname: Matskevich
authors.forename: Sophie
authors.initials: S
authors.lastname: Rutschmann
authors.forename: Julien
authors.initials: J
authors.lastname: Royet
authors.forename: Marcia
authors.initials: M
authors.lastname: Belvin
authors.forename: Jules A
authors.initials: JA
authors.lastname: Hoffmann
authors.forename: Dominique
authors.initials: D
authors.lastname: Ferrandon
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D004251:DNA Transposable Elements; D004330:Drosophila / Q000235:genetics / Q000276:immunology / Q000378:metabolism* / Q000382:microbiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D017344:Genes, Insect; D006090:Gram-Negative Bacteria / Q000502:physiology*; D006094:Gram-Positive Bacteria / Q000502:physiology*; D006458:Hemolymph / Q000378:metabolism; D006999:Hypocreales / Q000502:physiology; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism; D009154:Mutation; D010641:Phenotype; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism; D051193:Toll-Like Receptors
chemical_list: D002352:Carrier Proteins; D004251:DNA Transposable Elements; C054756:DptA protein, Drosophila; D029721:Drosophila Proteins; C480085:Gnbp1 protein, Drosophila; D019476:Insect Proteins; D011956:Receptors, Cell Surface; C068721:Tl protein, Drosophila; D051193:Toll-Like Receptors; C118897:peptidoglycan recognition protein; C086179:spz protein, Drosophila; C091227:DRS protein, Drosophila; D012697:Serine Endopeptidases; C460880:psh protein, Drosophila