title: A tyrosine-modified hypocrellin B with affinity for and photodamaging ability towards calf thymus DNA.
abstract: An enhanced photodamaging ability towards CT-DNA was achieved in a tyrosine-modified hypocrellin B by improving the affinity of the sensitizer to DNA.
authors.affiliation: Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100101, People's Republic of China.
authors.forename: Sheng Qin
authors.initials: SQ
authors.lastname: Xia
authors.forename: Jia Hong
authors.initials: JH
authors.lastname: Zhou
authors.forename: Jing Rong
authors.initials: JR
authors.lastname: Chen
authors.forename: Xue Song
authors.initials: XS
authors.lastname: Wang
authors.forename: Bao Wen
authors.initials: BW
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001665:Binding Sites; D002417:Cattle; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004249:DNA Damage / Q000187:drug effects* / Q000528:radiation effects*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010100:Oxygen / Q000378:metabolism; D010569:Perylene / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D011809:Quinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D013053:Spectrophotometry; D014443:Tyrosine / Q000737:chemistry*
chemical_list: D011809:Quinones; D014443:Tyrosine; D010569:Perylene; D004247:DNA; C427203:calf thymus DNA; D010100:Oxygen; C064522:hypocrellin B