title: Concise and efficient synthesis of 4-fluoro-1H-pyrrolo[2,3-b]pyridine.
abstract: Two routes describing the preparation of 4-fluoro-1H-pyrrolo[2,3-b]pyridine (4a) from 1H-pyrrolo[2,3-b]pyridine N-oxide (1) are presented. Regioselective fluorination was achieved using either the Balz-Schiemann reaction or lithium-halogen exchange. [reaction: see text]
authors.affiliation: Department of Discovery Chemistry, Pharmaceutical Research Institute, Bristol-Myers Squibb, 100 boulevard de l'Industrie, Candiac, Québec, Canada J5R 1J1.
authors.forename: Carl
authors.initials: C
authors.lastname: Thibault
authors.forename: Alexandre
authors.initials: A
authors.lastname: L'Heureux
authors.forename: Rajeev S
authors.initials: RS
authors.lastname: Bhide
authors.forename: Réjean
authors.initials: R
authors.lastname: Ruel