[Perspectives of the direct search for analgesics: new "targets" (lecture)].
Essential distinctions in the neurophysiologic and neurochemical mechanisms related with the shaping of pain syndromes presuppose the administration of different-action analgetics in coping with such syndromes. Data, obtained recently in studying the fundamental mechanisms of nociception and analgesia, denote a variety of new "targets" for potential analgetics, i.e. cannabinoid receptors, NMDA-receptors of subtype NR2B, kainate and metabotropic receptors, central n-cholinergic receptors, vanilloid receptors and purinoceptors, tetrodotoxin-insensitive sodium channel SNS/PN3, calcium channels of N-type and gabapenti-binding protein.
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D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D006801:Humans; D007473:Ion Channels / Q000037:antagonists & inhibitors; D008024:Ligands; D009619:Nociceptors / Q000378:metabolism / Q000502:physiology; D010146:Pain / Q000188:drug therapy / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000819:agonists / Q000037:antagonists & inhibitors; D011955:Receptors, Drug / Q000819:agonists / Q000037:antagonists & inhibitors
D000700:Analgesics; D007473:Ion Channels; D008024:Ligands; D011956:Receptors, Cell Surface; D011955:Receptors, Drug