title: The C-terminal ester of membrane anchored peptide ion channels affects anion transport.
abstract: Five heptapeptide derivatives, [CH3(CH2)17]2NCOCH2OCH2CO-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OR, in which R = ethyl, 2-propyl, heptyl, benzyl, and cyclohexylmethyl, were found to transport chloride anion through a phospholipid bilayer to varying extents dependent on the identity of R. It was concluded that the R group is a membrane anchor for the synthetic chloride channels.
authors.affiliation: Department of Chemistry, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8103, St. Louis, MO 63110, USA.
authors.forename: Natasha
authors.initials: N
authors.lastname: Djedovic
authors.forename: Riccardo
authors.initials: R
authors.lastname: Ferdani
authors.forename: Egan
authors.initials: E
authors.lastname: Harder
authors.forename: Jolanta
authors.initials: J
authors.lastname: Pajewska
authors.forename: Robert
authors.initials: R
authors.lastname: Pajewski
authors.forename: Paul H
authors.initials: PH
authors.lastname: Schlesinger
authors.forename: George W
authors.initials: GW
authors.lastname: Gokel
mesh_terms: D000838:Anions / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism; D004952:Esters / Q000737:chemistry*; D007473:Ion Channels / Q000737:chemistry* / Q000378:metabolism*; D017136:Ion Transport; D008081:Liposomes / Q000378:metabolism; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism
chemical_list: D000838:Anions; D002712:Chlorides; D004952:Esters; D007473:Ion Channels; D008081:Liposomes; D010455:Peptides; D010743:Phospholipids