Multiple roles of Sox2, an HMG-box transcription factor in avian neural crest development.
Expression of Sox2, which encodes an HMG-box-type transcription factor, is down-regulated in the neural plate when neural crest segregates from dorsal neural tube and remains low during crest cell migration. Sox2 expression is subsequently up-regulated in some crest-derived cells in the developing peripheral nervous system and is later restricted to glial sublineages. Misexpression of Sox2 and mutant forms of Sox2 both in neural plate explants and in embryonic ectoderm reveals that Sox2 inhibits neural crest formation as a transcriptional activator. Similar manipulation of Sox2 function in migratory and postmigratory neural crest-derived cells indicates that Sox2 regulates proliferation and differentiation in developing peripheral nervous system. Developmental Dynamics 229:74-86, 2004.
Wakamatsu
Yoshio
Y
Department of Developmental Neurobiology, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. wakasama@mail.cc.tohoku.ac.jp
Endo
Yukinori
Y
Osumi
Noriko
N
Weston
James A
JA
D000818:Animals; D030801:Animals, Genetically Modified; D002454:Cell Differentiation; D002455:Cell Division; D002478:Cells, Cultured; D002642:Chick Embryo; D003370:Coturnix; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D024002:HMGB Proteins; D008565:Membrane Proteins / Q000378:metabolism; D009154:Mutation; D009432:Neural Crest / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism*; D017933:Peripheral Nervous System / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D051880:Receptors, Notch; D055748:SOXB1 Transcription Factors; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*
D004268:DNA-Binding Proteins; D024002:HMGB Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D051880:Receptors, Notch; D055748:SOXB1 Transcription Factors; D014157:Transcription Factors