title: Composite pelvic exenteration: is it worthwhile?
abstract: BACKGROUND
  In locally advanced pelvic cancer, tumor fixation to the bony pelvis is regarded as unresectable and often inoperable. Few data exist regarding the futility or utility of pelvic exenteration with en bloc resection of involved portions of the bony pelvis.
  
  
  METHODS
  Thirty-four of 625 patients undergoing radical pelvic procedures had an en bloc resection of pelvic organs with portions of the bony pelvis. There were 19 female and 15 male patients, and the median age was 59 years. Primary neoplasms included 19 rectal, 6 cervicouterine, 4 anal, 3 vaginal, 1 sarcoma, and 1 penile. All but three patients underwent preoperative pelvic irradiation. Pelvic exenterations were posterior in 7 patients, anterior in 3, supralevator in 3, and total in 21 patients. Pelvic bony resections included portions of the sacrum-coccyx in 18 patients, ischium in 5, pubic symphysis in 4, and ischial pubic rami in 4, and hemipelvectomy was performed in 3.
  
  
  RESULTS
  Surgical morbidity occurred in 67.6% (23) of 24 patients. Median follow-up was 37 months. Pelvic or perineal tumor recurrence was concurrent with distant metastases in 9 patients (26.4%); 6 (17.6%) had only distant relapse, and 2 (5.8%) died with local recurrence alone. Overall cancer-related mortality rate was 50%. Five-year overall and cancer-specific survival rates were 44% and 52%, respectively.
  
  
  CONCLUSIONS
  Substantial survival can be accomplished for patients whose tumors are fixed to limited portions of the bony pelvis. These procedures are still associated with substantial morbidity, but operative mortality is infrequent.
authors.affiliation: Department of Surgery, Division of Surgical Oncology, St. Elizabeth's Medical Center and Tufts University School of Medicine, Boston, MA 02135, USA. marvin_lopez_md@cchcs.org
authors.forename: Marvin J
authors.initials: MJ
authors.lastname: Lopez
authors.forename: Pedro
authors.initials: P
authors.lastname: Luna-Pérez
mesh_terms: D001005:Anus Neoplasms / Q000473:pathology / Q000601:surgery; D001859:Bone Neoplasms / Q000601:surgery*; D000075202:Contraindications; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010385:Pelvic Exenteration; D011630:Pubic Bone / Q000473:pathology / Q000601:surgery; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery*; D012447:Sacrum / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000473:pathology / Q000601:surgery; D014625:Vaginal Neoplasms / Q000473:pathology / Q000601:surgery