title: Can particulate extraction from the ascending aorta reduce neurologic injury in cardiac surgery?
abstract: OBJECTIVE
  This study examined whether extraction of particulate emboli using intra-aortic filtration could decrease neurologic outcomes.
  
  
  METHODS
  Patients (N = 582) were enrolled in a prospective, controlled study and alternately assigned to the therapy arm (n = 304; intra-aortic filtration) or control arm (n = 278). Preoperative, procedural, and postoperative data were collected. Neurologic examinations included the National Institutes of Health Stroke Scale, Glasgow Coma Scale, and memory tests. Investigators administering neurologic tests were blinded to the study arm. By the use of logistic regression and propensity matching, composite neurologic outcomes (transient ischemic attack, stroke, delirium, coma, and memory deficit) were evaluated.
  
  
  RESULTS
  Patients in the filter group experienced a lower incidence of adverse neurologic outcomes than patients in the control group (4.3% vs 11.9%) (P <.001). There were significantly less transient ischemic attacks (0% vs 1.4%), delirium (3.0% vs 6.5%), and memory deficit (1.3% vs 6.2%). There were fewer strokes in the filter group compared with the control group (0.7% vs 2.2%), although the sample size was too small for a significant finding. Both groups experienced 1 coma outcome. The use of a filter was associated with an adjusted odds ratio of 0.375, implying that a patient who does not receive a filter is 2.7 times more likely to experience an adverse neurologic event. Logistic modeling also demonstrated that there are increasing chances of poor neurologic outcome with increasing age. The model indicates that there may be an increasing protective benefit from the filter with increasing age, although the interaction was not significant.
  
  
  CONCLUSIONS
  The extraction of particulate emboli using intra-aortic filtration resulted in decreased neurologic outcomes.
authors.affiliation: Klinik und Poliklinik für Herzchirurgie, Universitätsklinikum Bonn, Germany. c.schmitz@uni-bonn.de
authors.forename: Christoph
authors.initials: C
authors.lastname: Schmitz
authors.forename: Susanne
authors.initials: S
authors.lastname: Weinreich
authors.forename: Jennifer
authors.initials: J
authors.lastname: White
authors.forename: Irena
authors.initials: I
authors.lastname: Oengoeren
authors.forename: Rebecca
authors.initials: R
authors.lastname: Schneider
authors.forename: Deborah
authors.initials: D
authors.lastname: Schneider
authors.forename: Inga
authors.initials: I
authors.lastname: Speth
authors.forename: Christoph
authors.initials: C
authors.lastname: Pohl
authors.forename: Armin
authors.initials: A
authors.lastname: Welz
mesh_terms: D000368:Aged; D001011:Aorta; D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D003128:Coma / Q000517:prevention & control; D005260:Female; D005374:Filtration; D006801:Humans; D007430:Intraoperative Care; D002546:Ischemic Attack, Transient / Q000517:prevention & control*; D008297:Male; D019965:Neurocognitive Disorders / Q000517:prevention & control*; D011446:Prospective Studies; D012307:Risk Factors