Vesicular glutamate transporters in the lateral geniculate nucleus: expression of VGLUT2 by retinal terminals.
We used immunohistochemistry to localize vesicular glutamate transporters VGLUT1 and VGLUT2 in the rat lateral geniculate nucleus. The lateral geniculate nucleus is intensely immunoreactive for both transporters. Monocular eye removal abolished staining for VGLUT2 in a pattern corresponding to the distribution of terminals from the missing eye, without affecting distribution of VGLUT1 immunoreactivity. These data indicate retinal ganglion cells are the source of VGLUT2-containing synapses in the lateral geniculate nucleus.
Land
Peter W
PW
Department of Neurobiology, W1458 Biomedical Science Tower, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. pland@pitt.edu
Kyonka
E
E
Shamalla-Hannah
L
L
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism / Q000648:ultrastructure*; D015353:Eye Enucleation; D005829:Geniculate Bodies / Q000166:cytology* / Q000378:metabolism / Q000648:ultrastructure; D007150:Immunohistochemistry; D026901:Membrane Transport Proteins; D051381:Rats; D020318:Rats, Long-Evans; D012165:Retinal Ganglion Cells / Q000378:metabolism / Q000648:ultrastructure*; D013569:Synapses / Q000378:metabolism / Q000648:ultrastructure*; D050598:Vesicular Glutamate Transport Protein 1; D050599:Vesicular Glutamate Transport Protein 2; D033921:Vesicular Transport Proteins
D002352:Carrier Proteins; D026901:Membrane Transport Proteins; C493475:Slc17a6 protein, rat; C493466:Slc17a7 protein, rat; D050598:Vesicular Glutamate Transport Protein 1; D050599:Vesicular Glutamate Transport Protein 2; D033921:Vesicular Transport Proteins