title: [Pulmonary rhabdomyosarcoma generated during treatment of testicular tumor].
abstract: A 23-year-old male was admitted to our hospital for the management of pulmonary metastases. He had undergone right high orchiectomy, chemotherapy with four courses of PEB regimen (cisplatin, etoposide, bleomycin) and retroperitoneal lymph node dissection the previous year. The pathological findings showed mixed germ cell tumor (seminoma, yolk sac tumor, embryonal carcinoma) in the testis and mature teratoma in the draining lymph node. Two courses of salvage chemotherapy using a VIP regimen (etoposide, ifosfamide, cisplatin) were performed after diagnosis of pulmonary metastases, but had no affect on tumor size. Video-assisted excision of pulmonary metastases was then performed, giving a pathological diagnosis of rhabdomyosarcoma in all three resected tumors. The operation was followed by three courses of CYVADIC (cyclophosphamide, vincristine, adriamycin, dacarbazin) chemotherapy and oral cyclophosphamide, as a small residual tumor was suspected. These chemotherapeutic interventions have appeared effective, with no apparent recurrence of lesions at present, one year after the excision of pulmonary metastases.
authors.affiliation: Department of Urology, Asahikawa Medical College.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kita
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Okuyama
authors.forename: Yuji
authors.initials: Y
authors.lastname: Saga
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Shigeo
authors.initials: S
authors.lastname: Kaneko
authors.forename: Sunao
authors.initials: S
authors.lastname: Yachiku
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tokumitsu
authors.forename: Fumiei
authors.initials: F
authors.lastname: Inada
authors.forename: Hironori
authors.initials: H
authors.lastname: Ishida
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D018236:Carcinoma, Embryonal / Q000473:pathology / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003606:Dacarbazine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D018240:Endodermal Sinus Tumor / Q000473:pathology / Q000628:therapy; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000556:secondary* / Q000628:therapy; D008197:Lymph Node Excision; D008297:Male; D009919:Orchiectomy; D011013:Pneumonectomy; D012208:Rhabdomyosarcoma / Q000556:secondary* / Q000628:therapy; D018239:Seminoma / Q000473:pathology / Q000628:therapy; D013736:Testicular Neoplasms / Q000628:therapy*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D005047:Etoposide; D003606:Dacarbazine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin; D007069:Ifosfamide