The enemy at the gates. Ca2+ entry through TRPM7 channels and anoxic neuronal death.
In brain ischemia, gating of postsynaptic glutamate receptors is thought to initiate Ca2+ overload leading to excitotoxic neuronal death. In this issue, Aarts and colleagues describe a novel mechanism, whereby gating of TRPM7, a Ca2+-permeable nonselective cation channel, mediates Ca2+ overload and demise of anoxic neurons.
Nicotera
Pierluigi
P
MRC Toxicology Unit, University of Leicester, Lancaster Road, LE1 9HN Leicester, UK.
Bano
Daniele
D
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology; D016923:Cell Death; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000378:metabolism* / Q000503:physiopathology; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000378:metabolism*; D008565:Membrane Proteins; D009410:Nerve Degeneration / Q000378:metabolism* / Q000503:physiopathology; D009498:Neurotoxins / Q000037:antagonists & inhibitors / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases; D050053:TRPM Cation Channels
D007473:Ion Channels; D008565:Membrane Proteins; D009498:Neurotoxins; D050053:TRPM Cation Channels; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; C486583:TRPM7 protein, human; D002118:Calcium