Protective effect of Spirulina fusiformis on chemical-induced genotoxicity in mice.
Spirulina fusiformis given by oral route to mice at doses of 250, 500 and 1000 mg kg(-1) significantly inhibit the genotoxicity induced by cisplatin and urethane. In addition, a significant reduction in the extent of lipid peroxidation with concomitant increase in the liver enzymatic (GPx, GST, SOD, CAT) and non-enzymatic (reduced glutathione) antioxidants were observed.
Premkumar
K
K
Department of Genetics, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600-113, India. pkumpati@yahoo.co.in
Abraham
S K
SK
Santhiya
S T
ST
Ramesh
A
A
D000284:Administration, Oral; D000818:Animals; D001426:Bacterial Proteins; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000209:etiology / Q000517:prevention & control*; D002945:Cisplatin; D004305:Dose-Response Relationship, Drug; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D053545:Spirulina; D014520:Urethane
D001426:Bacterial Proteins; D010936:Plant Extracts; D020011:Protective Agents; D014520:Urethane; D002945:Cisplatin