title: Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria.
abstract: A series of ester and carbonate derivatives of the glycopeptide mannopeptimycin alpha (1) with potent activity against G+ bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci, was synthesized. The SAR data obtained from natural and semisynthetic compounds demonstrated the importance of a hydrophobic group in the terminal mannosyl moiety for antibacterial activity.
authors.affiliation: Department of Natural Products Chemistry, Chemical Sciences, Wyeth, Pearl River, NY 10965, USA. heh@wyeth.com
authors.forename: Haiyin
authors.initials: H
authors.lastname: He
authors.forename: Bo
authors.initials: B
authors.lastname: Shen
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Petersen
authors.forename: William J
authors.initials: WJ
authors.lastname: Weiss
authors.forename: Hui Y
authors.initials: HY
authors.lastname: Yang
authors.forename: Ting-Zhong
authors.initials: TZ
authors.lastname: Wang
authors.forename: Russell G
authors.initials: RG
authors.lastname: Dushin
authors.forename: Frank E
authors.initials: FE
authors.lastname: Koehn
authors.forename: Guy T
authors.initials: GT
authors.lastname: Carter
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002254:Carbonates / Q000737:chemistry* / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects* / Q000502:physiology; D004952:Esters; D006020:Glycopeptides; D051379:Mice; D008826:Microbial Sensitivity Tests / Q000706:statistics & numerical data; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development
chemical_list: D000900:Anti-Bacterial Agents; D002254:Carbonates; D004952:Esters; D006020:Glycopeptides; C478082:mannopeptimycin