title: High levels of SIVmnd-1 replication in chronically infected Mandrillus sphinx.
abstract: Viral loads were investigated in SIVmnd-1 chronically infected mandrills and the results were compared with those previously observed in other nonpathogenic natural SIV infections. Four naturally and 11 experimentally SIVmnd-1-infected mandrills from a semi-free-ranging colony were studied during the chronic phase of infection. Four SIVmnd-1-infected wild mandrills were also included for comparison. Twelve uninfected mandrills were used as controls. Viral loads in all chronically infected mandrills ranged from 10(5) to 9 x 10(5) copies/ml and antibody titers ranged from 200 to 14,400 and 200 to 12,800 for anti-V3 and anti-gp36, respectively. There were no differences between groups of wild and captive mandrills. Both parameters were stable during the follow-up, and no clinical signs of immune suppression were observed. Chronic SIVmnd-1-infected mandrills presented slight increases in CD20+ and CD28+/CD8+ cell counts, and a slight decrease in CD4+/CD3+ cell counts. A slight CD4+/CD3+ cell depletion was also observed in old uninfected controls. Similar to other nonpathogenic models of lentiviral infection, these results show a persistent high level of SIVmnd-1 replication during chronic infection of mandrills, with minimal effects on T cell subpopulations.
authors.affiliation: Laboratoire de Virologie, UGENET, SEGC, Réserve de la Lopé, Centre de Primatologie, Centre International de Recherches Médicales, BP769, Franceville, Gabon, France.
authors.forename: Ivona
authors.initials: I
authors.lastname: Pandrea
authors.forename: Richard
authors.initials: R
authors.lastname: Onanga
authors.forename: Christopher
authors.initials: C
authors.lastname: Kornfeld
authors.forename: Pierre
authors.initials: P
authors.lastname: Rouquet
authors.forename: Olivier
authors.initials: O
authors.lastname: Bourry
authors.forename: Stephen
authors.initials: S
authors.lastname: Clifford
authors.forename: Paul T
authors.initials: PT
authors.lastname: Telfer
authors.forename: Kate
authors.initials: K
authors.lastname: Abernethy
authors.forename: Lee T W
authors.initials: LT
authors.lastname: White
authors.forename: Paul
authors.initials: P
authors.lastname: Ngari
authors.forename: Michaela
authors.initials: M
authors.lastname: Müller-Trutwin
authors.forename: Pierre
authors.initials: P
authors.lastname: Roques
authors.forename: Preston A
authors.initials: PA
authors.lastname: Marx
authors.forename: Francois
authors.initials: F
authors.lastname: Simon
authors.forename: Cristian
authors.initials: C
authors.lastname: Apetrei
mesh_terms: D000818:Animals; D000835:Animals, Wild; D002908:Chronic Disease; D004195:Disease Models, Animal; D016131:Lymphocyte Subsets; D008992:Monkey Diseases / Q000821:virology*; D010215:Papio / Q000821:virology*; D012367:RNA, Viral / Q000097:blood; D016097:Simian Acquired Immunodeficiency Syndrome / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000472:pathogenicity* / Q000502:physiology; D019562:Viral Load; D014779:Virus Replication
chemical_list: D012367:RNA, Viral