Association between posterior uveal melanoma and iris freckles, iris naevi, and choroidal naevi.
OBJECTIVE
To investigate the association between posterior uveal melanoma and iris freckles, iris naevi, and choroidal naevi.


METHODS
Cross sectional study of 65 patients with posterior uveal melanoma and 218 controls. Iris colour, iris freckles, iris naevi, and choroidal naevi were recorded for each eye of each patient.


RESULTS
Iris freckles were present in 40 (61.5%) patients with melanoma and 135 (61.9%) controls (p = 0.494). Iris naevi were present in four (6.2%) patients with melanoma and nine (4.1%) controls (p = 0.955). Choroidal naevi were present in 12 (18.5%) patients with melanoma and 38 (17.4%) controls (p = 0.815).


CONCLUSIONS
This study did not detect an association between posterior uveal melanoma and iris freckles, iris naevi, or choroidal naevi.
Harbour
J W
JW
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, Box 8069, 660 S. Euclid Avenue, St Louis, MO 63110, USA. harbour@vision.wustl.edu
Brantley
M A
MA
Hollingsworth
H
H
Gordon
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002830:Choroid Neoplasms / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007499:Iris Diseases / Q000473:pathology*; D015811:Iris Neoplasms / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000473:pathology*; D008548:Melanosis / Q000473:pathology; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D009506:Nevus / Q000473:pathology; D011446:Prospective Studies; D014604:Uveal Neoplasms / Q000473:pathology*