Intergenerational transmission of tobacco use and dependence: a transdisciplinary perspective.
Numerous questions remain regarding the intergenerational transmission of tobacco use and dependence, and some of these questions are best approached from a transdisciplinary perspective. For example, considering both genetic and environmental influences on cigarette smoking promises to be a fruitful venue for future investigations. In this paper, we consider the evidence regarding intergenerational influences on the transmission of tobacco use and nicotine dependence in both humans and animal models; our focus will be on genetic influences, in utero exposure to nicotine, and some postnatal influences. Research gaps that exist between scientific disciplines are highlighted, and some directions for future research are suggested.
Shenassa
Edmond D
ED
Brown Medical School, Centers for Behavioral & Preventive Medicine, Providence, RI 02903, USA. Edmond_Shenassa@brown.edu
McCaffery
Jeanne M
JM
Swan
Gary E
GE
Khroyan
Taline V
TV
Shakib
Sohaila
S
Lerman
Caryn
C
Lyons
Michael
M
Mouttapa
Michelle
M
Niaura
Raymond S
RS
Buka
Stephen L
SL
Leslie
Frances
F
Santangelo
Susan L
SL
D000328:Adult; D004195:Disease Models, Animal; D004777:Environment; D005260:Female; D005731:Ganglionic Stimulants / Q000494:pharmacology*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007400:Interprofessional Relations; D009538:Nicotine / Q000494:pharmacology*; D010641:Phenotype; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012106:Research / Q000458:organization & administration / Q000639:trends; D012307:Risk Factors; D014029:Tobacco Use Disorder / Q000235:genetics*
D005731:Ganglionic Stimulants; D009538:Nicotine