title: Cyclic tetrapeptides bearing a sulfhydryl group potently inhibit histone deacetylases.
abstract: New inhibitors of histone deacetylase (HDAC) containing a sulfhydryl group were designed on the basis of the corresponding hydroxamic acid (CHAP31) and FK228. Their disulfide dimers and hybrids exhibited potent HDAC inhibitory activity in vivo with potential as anticancer prodrugs. [structure: see text]
authors.affiliation: Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, Hibikino, Wakamatsu-ku, Kitakyushu 808-0196, Japan. nishino@life.kyutech.ac.jp
authors.forename: Norikazu
authors.initials: N
authors.lastname: Nishino
authors.forename: Binoy
authors.initials: B
authors.lastname: Jose
authors.forename: Shinji
authors.initials: S
authors.lastname: Okamura
authors.forename: Shutoku
authors.initials: S
authors.lastname: Ebisusaki
authors.forename: Tamaki
authors.initials: T
authors.lastname: Kato
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sumida
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshida
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D003460:Crystallization; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D056572:Histone Deacetylase Inhibitors; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D009842:Oligopeptides; D011355:Prodrugs; D013438:Sulfhydryl Compounds