Transient intraventricular conduction delay associated with concurrent intake of propafenone and antineoplastic agents.
An 82-year old man was admitted with acute pulmonary edema. Myocardial ischemia and electrolyte abnormalities were excluded and he responded promptly to frusemide, nitrates and morphine. On admission, the duration of the QRS interval was markedly abnormal at 240 ms with a nonspecific intraventricular conduction defect pattern, of left bundle branch block type. This finding was not present three weeks prior to his admission, and was felt to be the result of drug interaction between propafenone and antineoplastic agents, as evidenced by resolution of the clinical and electrocardiographic picture after discontinuation of these agents.
Kolettis
Theofilos M
TM
Department of Cardiology, University Hospital, Ioannina, Greece. thkolet@cc.uoi.gr
Naka
Katerina K
KK
Katsouras
Christos
C
Michalis
Lambros K
LK
Bourantas
Konstantinos
K
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D011405:Propafenone / Q000009:adverse effects*; D011654:Pulmonary Edema / Q000139:chemically induced; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced*
D000889:Anti-Arrhythmia Agents; D000970:Antineoplastic Agents; D011405:Propafenone