title: Strategies for heterocyclic construction via novel multicomponent reactions based on isocyanides and nucleophilic carbenes.
abstract: This Account focuses mainly on our recent endeavors in the area of multicomponent reactions (MCRs) involving zwitterionic species generated by the addition of isocyanides and nucleophilic carbenes such as dimethoxycarbene and N-heterocyclic carbenes to activated alkynes. The strategy employed encompasses the interception of 1:1 zwitterionic species, generated in situ with a wide range of electrophiles. The new MCRs developed offer an efficient and convenient entry into several heterocycles of biological and synthetic importance.
authors.affiliation: Organic Chemistry Division, Regional Research Laboratory (CSIR), Trivandrum 695 019, India. vijaynair_2001@yahoo.com
authors.forename: Vijay
authors.initials: V
authors.lastname: Nair
authors.forename: C
authors.initials: C
authors.lastname: Rajesh
authors.forename: A U
authors.initials: AU
authors.lastname: Vinod
authors.forename: S
authors.initials: S
authors.lastname: Bindu
authors.forename: A R
authors.initials: AR
authors.lastname: Sreekanth
authors.forename: J S
authors.initials: JS
authors.lastname: Mathen
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Balagopal
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003486:Cyanides / Q000737:chemistry*; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006838:Hydrocarbons; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry*; D008956:Models, Chemical; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D003486:Cyanides; D006571:Heterocyclic Compounds; D006838:Hydrocarbons; C030011:carbene; D008697:Methane