title: Chromosome 7q31 allelic imbalance and somatic mutations of RAY1/ST7 gene in colorectal cancer.
abstract: ST7 is a putative tumor suppressor gene on chromosome 7q31. However, the role of ST7 as a tumor suppressor is uncertain as somatic mutations have been difficult to demonstrate. In order to investigate the genetic role of RAY1/ST7 in tumorigenesis, we have screened 135 colorectal cancers for loss of heterozygosity (LOH) at chromosome 7q31. The entire RAY1/ST7 gene, including intron/exon boundaries and alternate 5' and 3' sequences of 15/124 (12%) informative cancers with LOH were characterized. No somatic mutations of the RAY1/ST7 gene were observed. Our results do not support a role for RAY1/ST7 as a colorectal cancer tumor suppressor gene.
authors.affiliation: Department of Surgery, Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Ave, Suite 1225, Toronto, Ont. M5G IX5, Canada.
authors.forename: Riad
authors.initials: R
authors.lastname: Haddad
authors.forename: John B
authors.initials: JB
authors.lastname: Vincent
authors.forename: Robert
authors.initials: R
authors.lastname: Gryfe
authors.forename: Hyeja
authors.initials: H
authors.lastname: Kim
authors.forename: Joseph
authors.initials: J
authors.lastname: Wen
authors.forename: Mark
authors.initials: M
authors.lastname: Redston
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Scherer
authors.forename: Steven
authors.initials: S
authors.lastname: Gallinger
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics*; D022981:Allelic Imbalance; D002897:Chromosomes, Human, Pair 7; D015179:Colorectal Neoplasms / Q000235:genetics*; D006801:Humans; D009154:Mutation; D011506:Proteins / Q000235:genetics*; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: D011506:Proteins; C412123:ST7 protein, human; D025521:Tumor Suppressor Proteins