title: The syntheses of tricyclic analogues of O6-methylguanine.
abstract: The syntheses of the novel pyrrolo[2,3-d]pyrimidine-based heterocycles as tricyclic analogues of O6-methylguanine are described. Compound 5 is a weak inhibitor of human O6-alkylguanine DNA alkyltransferase.
authors.affiliation: Centre for Chemical Biology, Department of Chemistry, Krebs Institute, University of Sheffield, Brook Hill, Sheffield, UK S3 7HF.
authors.forename: David M
authors.initials: DM
authors.lastname: Hammond
authors.forename: Dolorès
authors.initials: D
authors.lastname: Edmont
authors.forename: Ana R
authors.initials: AR
authors.lastname: Hornillo-Araujo
authors.forename: David M
authors.initials: DM
authors.lastname: Williams
mesh_terms: D001665:Binding Sites; D003500:Cyclization; D006147:Guanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000037:antagonists & inhibitors
chemical_list: D006147:Guanine; C008449:O-(6)-methylguanine; D019853:O(6)-Methylguanine-DNA Methyltransferase