X-linked dominant inheritance in palmoplantar keratoderma with leukokeratosis: a study of the pedigree of two cases.
Keratoderma of the palms and soles is not of rare occurrence. Its association with leukokeratosis of the mouth is well recognized. We describe two siblings having callosities like keratoderma over the weight bearing areas of soles, pressure areas of palms and palmar creases with leukokeratosis of cheeks. On study of the pedigree of these probands we could trace the trait transmission by a rare X-linked dominant mechanism.
Sharma
Prafulla Kumar
PK
Department of Dermatology & STD Dr. Ram Manohar Lohia Hospital, New Delhi-110001, India.
Rath
Namita
N
Chauhan
Ruchi
R
Sharma
Suresh Kumar
SK
Kar
Hemant Kumar
HK
D000328:Adult; D003937:Diagnosis, Differential; D005111:Extrachromosomal Inheritance; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000150:complications / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D008297:Male; D009059:Mouth Diseases / Q000150:complications / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D035781:Siblings