title: Adenosquamous histology predicts poor outcome in low-risk stage IB1 cervical adenocarcinoma.
abstract: OBJECTIVE
  The purpose of this study was to identify poor prognostic factors of low-risk stage IB1 cervical adenocarcinoma
  
  
  METHODS
  . All women diagnosed with stage IB1 cervical adenocarcinoma between 1982 and 2002 were identified at our three institutions. Data were extracted from medical records. Patients were retrospectively assigned to a low- or intermediate/high-risk cohort based on the surgical-pathologic eligibility criteria of two randomized controlled trials of adjuvant therapy in early stage cervical cancer, Gynecologic Oncology Group protocols 92 and 109. Multivariate analysis was performed.
  
  
  RESULTS
  Two hundred thirty women diagnosed with stage IB1 cervical adenocarcinoma had an overall 5-year survival of 89%. Adenosquamous cell type (P < 0.01) was the only independent risk factor of disease recurrence in the low-risk group (n = 178). The 5-year disease-free survival for low-risk adenosquamous patients was 79%, compared to 96% for other histologic subtypes (P < 0.01). Low-risk case subjects developed fewer disease recurrences than those in the intermediate/high-risk (n = 52) category (7% vs 46%; P < 0.01). The 5-year disease-free survival for intermediate/high-risk patients was 51% and no additional risk factors were identified.
  
  
  CONCLUSIONS
  Adenosquamous histology is predictive of disease recurrence and decreased survival in low-risk stage IB1 cervical adenocarcinoma. This risk factor should be considered in future clinical trials of adjuvant therapy.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9032, USA. john.schorge@utsouthwestern.edu
authors.forename: Jayanthi S
authors.initials: JS
authors.lastname: Lea
authors.forename: Robert L
authors.initials: RL
authors.lastname: Coleman
authors.forename: Elizabeth O
authors.initials: EO
authors.lastname: Garner
authors.forename: Linda R
authors.initials: LR
authors.lastname: Duska
authors.forename: David S
authors.initials: DS
authors.lastname: Miller
authors.forename: John O
authors.initials: JO
authors.lastname: Schorge
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018196:Carcinoma, Adenosquamous / Q000473:pathology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000473:pathology*