Relation of response of subclinical atherosclerosis detected by electron beam tomography to baseline low-density lipoprotein cholesterol levels.
Calcified plaque progression by electron beam tomography was evaluated in 176 aggressively treated asymptomatic patients. Similar plaque progression was noted irrespective of baseline low-density lipoprotein cholesterol levels, including those with low-density lipoprotein cholesterol <100 mg/dl. These findings indicate that subclinical atherosclerosis may respond to drug therapy in a fashion parallel to that of clinical disease demonstrated in the Heart Protection Study.
Hecht
Harvey S
HS
Beth Israel Medical Center, New York, New York 10003, USA. hhecht@aol.com
Harman
S Mitchell
SM
D000924:Anticholesteremic Agents / Q000008:administration & dosage*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009525:Niacin / Q000008:administration & dosage; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D000924:Anticholesteremic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D009525:Niacin; D002784:Cholesterol