A patient with E. coli-induced pyelonephritis and sepsis who transiently exhibited symptoms associated with primary biliary cirrhosis.
A 28-year-old woman had chief complaints of headache and a 40 degrees C fever. At this time, findings indicative of inflammation including elevated CRP and increased WBC were observed, and E. coli was detected on blood and urine culture. As a result, the patient was diagnosed with pyelonephritis and sepsis. Furthermore, markedly increased hepatobiliary enzymes and elevated anti-mitochondrial antibody were confirmed. The administration of antimicrobial agents resulted in improvement of the pyelonephritis and sepsis and normalization of hepatobiliary enzyme and anti-mitochondrial antibody levels. It has been documented that the incidence of urinary tract infection is high among patients with primary biliary cirrhosis (PBC). The findings obtained from the present patient are of considerable interest in elucidating the mechanism of onset in PBC.
Ohno
Nobuhiko
N
Department of Infectious Disease, Graduate School of Medicine, The University of Tokyo, Tokyo.
Ota
Yasuo
Y
Hatakeyama
Syuji
S
Yanagimoto
Shintaro
S
Morisawa
Yuji
Y
Tsukada
Kunihisa
K
Koike
Kazuhiko
K
Kimura
Satoshi
S
D000328:Adult; D004927:Escherichia coli Infections / Q000097:blood / Q000150:complications* / Q000652:urine; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000097:blood / Q000382:microbiology* / Q000652:urine; D011704:Pyelonephritis / Q000097:blood / Q000382:microbiology* / Q000652:urine; D018805:Sepsis / Q000097:blood / Q000382:microbiology* / Q000652:urine