[Effect of the composition of branched chain amino acids, taurine, and tryptophan on the amino acid metabolism in experimental models of alcoholism].
Ethanol withdrawal after forced alcoholization of rats according to Majchrowicz led to the development of amino acid imbalance in the pool of free amino acids in the liver (increasing levels of alanine, aspartate, glutamate, glutamine and histidine, decreasing levels of glycine, lysine, threonine and taurine) and blood plasma (increasing levels of tyrosine and alanine, decreasing levels of most glycogen aminoacids, branched-chain aminoacids and Lys). Less profound changes were observed after prolonged alcohol intoxication (decreasing levels of alanine, ornitine, citrulline and increasing level of Glu in liver, increasing levels of sulfur-containing compounds, Asp and Lys in blood plasma). Amino acid mixture which contained branched-chain amino acids, taurine and tryptophan administered intragastrically was found to correct levels of sulfur-containing amino acids, threonine, lysine and isoleucine after ethanol withdrawal and to eliminate disorders in urea cycle, exchange of threonine, glycine and phenylalanine after prolonged alcohol intoxication.
Smirnov
V Iu
VIu
Institute of Biochemistry, National Academy of Sciences of Belarus, Grodno.
Razvodovskiĭ
Iu E
IuE
Doroshenko
E M
EM
Ostrovskiĭ
S Iu
SIu
D000284:Administration, Oral; D000437:Alcoholism / Q000097:blood / Q000378:metabolism*; D000596:Amino Acids / Q000097:blood / Q000378:metabolism; D000597:Amino Acids, Branched-Chain / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013375:Substance Withdrawal Syndrome / Q000097:blood / Q000378:metabolism / Q000517:prevention & control*; D013654:Taurine / Q000008:administration & dosage / Q000494:pharmacology*; D014364:Tryptophan / Q000008:administration & dosage / Q000494:pharmacology*
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D013654:Taurine; D014364:Tryptophan