title: Further utilization of mucohalic acids: palladium-free, regioselective etherification and amination of alpha,beta-dihalo gamma-methoxycarbonyloxy and gamma-acetoxy butenolides.
abstract: Palladium-free etherification and amination of mucohalic acid methyl carbonates 1e (3,4-dichloro-5-methoxycarbonyloxy-5H-furan-2-one) and 1f (3,4-dibromo-5-methoxycarbonyloxy-5H-furan-2-one) and mucochloric acid acetate 1h (3,4-dichloro-5-acetoxy-5H-furan-2-one) was achieved to afford gamma-functionalized alpha,beta-unsaturated gamma-butyrolactones in good to excellent yield. [reaction: see text]
authors.affiliation: Chemical Research and Development, Pfizer Global Research & Development, Ann Arbor Laboratories, Pfizer, Inc., 2800 Plymouth Road, Ann Arbor, MI 48105, USA.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Blazecka
authors.forename: Daniel
authors.initials: D
authors.lastname: Belmont
authors.forename: Tim
authors.initials: T
authors.lastname: Curran
authors.forename: Derek
authors.initials: D
authors.lastname: Pflum
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang