title: Fig and mulberry cross-allergy.
abstract: BACKGROUND
  Hypersensitivity reactions to ingestion of figs (Ficus carica) and mulberries (Morus nigra and Morus alba) are considered uncommon and have never been reported as occurring in the same patient.
  
  
  OBJECTIVE
  To determine whether hypersensitivity to figs and mulberries can induce cross-allergy.
  
  
  METHODS
  We describe 3 cases of associated fig and mulberry allergy in 3 patients with multiple sensitizations to food allergens (mostly fruit) and airborne allergens. The presence of specific IgE was investigated by skin prick tests and radioallergosorbent tests.
  
  
  RESULTS
  The 3 patients had a convincing clinical history of food allergy caused by eating fresh figs, and in all 3 cases clinical and/or laboratory evidence of sensitization to mulberries was also collected.
  
  
  CONCLUSIONS
  We reason that Ficus and Morus are closely related genera of the Moraceae family and speculate that hypersensitivity to figs and mulberries might be associated as the result of allergen cross-reactivity rather than mere coincidence.
authors.affiliation: Department of Allergology and Clinical Immunology, University of Foggia, Foggia, Italy.
authors.forename: Maria Filomena
authors.initials: MF
authors.lastname: Caiaffa
authors.forename: Vito Michele
authors.initials: VM
authors.lastname: Cataldo
authors.forename: Alfredo
authors.initials: A
authors.lastname: Tursi
authors.forename: Luigi
authors.initials: L
authors.lastname: Macchia
mesh_terms: D000328:Adult; D000918:Antibody Specificity / Q000276:immunology; D002648:Child; D003429:Cross Reactions / Q000276:immunology*; D005260:Female; D030681:Ficus / Q000009:adverse effects* / Q000276:immunology*; D005512:Food Hypersensitivity / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D008297:Male; D008875:Middle Aged; D031625:Morus / Q000009:adverse effects* / Q000276:immunology*; D011852:Radioallergosorbent Test; D012882:Skin Tests
chemical_list: D007073:Immunoglobulin E