[Effect of cadmium chloride on polyphosphoinositides content in the rat liver and kidneys].
The influence of cadmium chloride on the content of some fractions of polyphosphoinositides in the liver and kidneys of rats has been investigated in the work. We have reported that a single administration of sublethal dose of cadmium chloride leads to the long-term elevation of the content of diacylglycerol, which is responsible for the activation of protein kinase C. The increase of triphosphoinositides fraction content may be connected with activation of phosphoinositid-3-kinase and with accumulation of phosphatidylinositol-3,4-diphosphate and phosphatidilinositol-3,4,5-triphosphate, which are known as activators of some protein kinase C isoforms and also play an important role in the mitogen-activated protein kinase signaling pathway. The lipids fractions content changes were similar in the liver and kidneys, but had different time of response.
Kaliman
P A
PA
Karazin Kharkov National University, Ukraine. Pavel.A.Kaliman@univer.kharkov.ua
Borikov
A Iu
AIu
D000818:Animals; D019256:Cadmium Chloride / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D018129:Phosphatidylinositol Phosphates; D019256:Cadmium Chloride