Nonfunctioning adrenocortical carcinoma in a child.
Pediatric nonfunctioning adrenocortical carcinoma is a very rare tumor. A 4-year-old girl was admitted complaining of abdominal pain. Physical examination revealed an abdominal mass. There were no clinical or laboratory signs of hormonal abnormality. Abdominal ultrasonography revealed a polylobular mass. Intravenous pyelography showed marked compression of the kidney by a tumor. The tumor was excised together with the right kidney. The histopathological diagnosis was adrenocortical carcinoma. Although there is a greater incidence of germ line p53 mutations with adrenocortical carcinoma, the tumor suppressor gene p53 was not mutated in our case. The girl died 2 months after surgery from complications of chemotherapy.
Kanmaz
Turan
T
Department of Pediatric Surgery, Harran University, Faculty of Medicine, Sanliurfa, Turkey. kanmaz@surgery.wisc.edu
Demirbilek
Savas
S
Ozardali
Ilyas
I
Safali
Mukerrem
M
Guran
Sefik
S
Yucesan
Selcuk
S
D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000473:pathology*; D018268:Adrenocortical Carcinoma / Q000175:diagnosis / Q000473:pathology*; D002675:Child, Preschool; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
D016159:Tumor Suppressor Protein p53