title: Single nucleotide polymorphism study of IDDM 17 in a Bedouin Arab family.
abstract: Type 1 diabetes is an autoimmune disease caused by a combination of genetic and environmental factors. On the basis of a genomic search for linkage in a Bedouin Arab family with 19 members with type 1 diabetes, we previously mapped the IDDM 17 locus to the chromosome 10q25.1 region. The result from a recent genome scan showed suggestive evidence of linkage of IDDM 17 in a subset of Caucasian families in which all affected individuals have DR3, indicating that the IDDM 17 locus might have a measurable effect in Caucasian populations from the United Kingdom and the United States. High-resolution SNP typing provides strong evidence of linkage disequilibrium to the IDDM 17 locus.
authors.affiliation: Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.
authors.forename: Fei
authors.initials: F
authors.lastname: Bao
authors.forename: Sunanda R
authors.initials: SR
authors.lastname: Babu
authors.forename: Christine M
authors.initials: CM
authors.lastname: Roberts
authors.forename: Allison K
authors.initials: AK
authors.lastname: Martin
authors.forename: Katherine
authors.initials: K
authors.lastname: Gowan
authors.forename: George S
authors.initials: GS
authors.lastname: Eisenbarth
authors.forename: Pamela R
authors.initials: PR
authors.lastname: Fain
mesh_terms: D018912:Arabs; D002879:Chromosomes, Human, Pair 10; D003922:Diabetes Mellitus, Type 1 / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide