Inhibitory effects of several flavonoids on E-selectin expression on human umbilical vein endothelial cells stimulated by tumor necrosis factor-alpha.
The present study investigates the suppressive effect of flavonoids on TNF-alpha-stimulated E-selectin expression on HUVECs by carrying out a comparative examination of the 37 flavonoids. Several flavonoids: fisetin, luteolin and apigenin (subclass of flavone), kaempferol and quercetin (flavonols), eriodictyol (flavanones), genistein (isoflavones) and butein (chalcone) exhibit the inhibitory effects. Considerations to the structure of flavonoids, the C2-C3 double bond of C-ring and 4-oxo functional group are essential for their inhibition activities. These results help to explain the pharmacological efficacy of flavonoids as anti-inflammatory compounds.
Takano-Ishikawa
Yuko
Y
National Food Research Institutes, Kannondai, Tsukuba, Ibaraki, Japan. yuko@nfri.affrc.go.jp
Goto
Masao
M
Yamaki
Kohji
K
D019040:E-Selectin / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008517:Phytotherapy; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha; D014471:Umbilical Veins / Q000378:metabolism
D019040:E-Selectin; D005419:Flavonoids; D014409:Tumor Necrosis Factor-alpha