title: Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones.
abstract: A convenient and efficient palladium-catalysed retro-ene-assisted method has been developed to prepare a series of 5-substituted-6-phenyl-3(2H)-pyridazinones as potential antiplatelet drugs. The most active compounds were those that contain a 3-phenyl-3-oxo-propenyl fragment or a phenylthio group at position 5 of the heterocyclic ring.
authors.affiliation: Departamento de Qui;mica Orgánica, Laboratorio de Qui;mica Farmacéutica, Drug Research & Development Group, Universidade de Santiago de Compostela, 15782-, Santiago de Compostela, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Coelho
authors.forename: Eddy
authors.initials: E
authors.lastname: Sotelo
authors.forename: Nuria
authors.initials: N
authors.lastname: Fraiz
authors.forename: Matilde
authors.initials: M
authors.lastname: Yáñez
authors.forename: Reyes
authors.initials: R
authors.lastname: Laguna
authors.forename: Ernesto
authors.initials: E
authors.lastname: Cano
authors.forename: Enrique
authors.initials: E
authors.lastname: Raviña
mesh_terms: D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D010975:Platelet Aggregation Inhibitors; D011724:Pyridazines