title: Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues.
abstract: Novel quinoxaline antibiotics having the methylenedithioether bridge as an analogue of echinomycin have been synthesized by insertion of methylene moiety between -S-S- bond. The compound 1a shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistant enterococci) within MIC range 0.5-8 microg/mL. According to the eukaryotic or prokaryotic data, 1a might be a first analogue to replace echinomycin.
authors.affiliation: Center for Molecular Design and Synthesis, Department of Chemistry, Korea Advanced Institute of Science and Technology, 305-701, Taejon, South Korea.
authors.forename: Yun Bong
authors.initials: YB
authors.lastname: Kim
authors.forename: Yong Hae
authors.initials: YH
authors.lastname: Kim
authors.forename: Ju Youn
authors.initials: JY
authors.lastname: Park
authors.forename: Soo Kie
authors.initials: SK
authors.lastname: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D045744:Cell Line, Tumor; D004448:Echinomycin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D011810:Quinoxalines; D004448:Echinomycin