Relationship between the beta3-adrenoceptor gene variant and body fat in Japanese children.
In this study, we investigated whether the variant of the beta3-adrenoceptor gene is associated with accumulation of body fat in Japanese junior high school students. A total of 87 junior high school students, 50 boys and 37 girls, participated in this survey. The beta3-adrenoceptor gene variant was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Accumulation of body fat was assessed by skinfold thickness at the triceps and subscapular with a skinfold caliper. There was no difference between boys and girls in the frequency of the beta3-adrenoceptor gene allele. There were no significant differences in body mass index and percent body fat between the Arg carriers (Trp/Arg or Arg/Arg) and the Arg noncarriers (Trp/Trp) for either sex. The Trp64Arg variant of the beta3-adrenoceptor gene does not seem to have a strong effect on the accumulation of body fat in this group of Japanese junior high school students.
Kurokawa
Naoyuki
N
Department of Environmental Health Sciences, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan. n-kuro@ehs.med.tohoku.ac.jp
Nakai
Kunihiko
K
Kameo
Satomi
S
Liu
Zhong-Min
ZM
Satoh
Hiroshi
H
D000273:Adipose Tissue / Q000473:pathology*; D000293:Adolescent; D001120:Arginine / Q000737:chemistry; D001823:Body Composition / Q000235:genetics*; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D009765:Obesity / Q000235:genetics; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D012737:Sex Factors; D012885:Skinfold Thickness; D014364:Tryptophan / Q000737:chemistry
D022702:Receptors, Adrenergic, beta-3; D014364:Tryptophan; D001120:Arginine