[Advances in researches on lactate dehydrogenase-C4 isozyme].
Lactate dehydrogenase-C4 isozyme has been widely studied as the sperm-specific antigen in the research of the contraceptive vaccine. Developmental and testis-specific expression of the LDH-C gene requires mechanisms for activation in germ cells and repression in somatic cells. LDH-C promoter, several transcription factors and methylation of CpG dinucleotides have been proved of governing action on LDH-C gene transcription. The strategy is to induce antibodies in the female reproductive tract against LDH-C antigens at a sufficient level to block fertilization. Chemically modified LDH-C4 offers a potential application in the induction of infertility of homologous species in marked contrast to native LDH-C4. In addition, advances are being made in researches on the male contraceptive vaccine and synthetic peptide immunocontraceptive.
Xiong
Yong-Zhong
YZ
Center for Laboratory Medicine, Fuzhou General Hospital, PLA, Fuzhou, Fujian 350025, China.
Lan
Feng-Hua
FH
D000818:Animals; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000276:immunology; D007770:L-Lactate Dehydrogenase / Q000235:genetics / Q000276:immunology*; D008297:Male; D051379:Mice; D010215:Papio; D011817:Rabbits; D013094:Spermatozoa / Q000201:enzymology*; D014158:Transcription, Genetic; D022642:Vaccines, Contraceptive / Q000276:immunology*
D007527:Isoenzymes; D022642:Vaccines, Contraceptive; D007770:L-Lactate Dehydrogenase; C409673:lactate dehydrogenase C4