[Neo-angiogenesis in immunohistochemical techniques as a prognostic factor in endometrial carcinoma].
OBJECTIVE
Angiogenesis in malignant tumors is a prognostic factor associated with tumor growth and metastasis. The aim of the research was: determination of the angiodensity rate in two immunohistochemical techniques, estimation of the value of the examined parameter at different stages of clinical progression and histological differentiation of endometrial carcinoma, and analysis of the obtained values as prognostic factors in the disease process.


METHODS
The examination covered 86 women treated surgically for endometrial carcinoma. The preliminary histological evaluation was followed by immunohistochemical methods. The microvessels within the invasive cancer were highlighted by means of immuno-cytochemical staining to detect CD-31 and CD-105 antigen. The average value of angiodesity was estimated by means of a computer image analyser.


RESULTS
The group of patients at the preinvasive stage of the disease manifested significantly statistically lower values of angiodensity. It was detected that the histological differentiation of carcinoma does not influence intensification of angiogenesis. Higher values of this parameter have an adverse influence on the survival rate.


CONCLUSIONS
The evaluation of the angiodensity coefficient can be a helpful prognostic parameter in endometrial carcinoma.
Szymański
Wiesław
W
Katedry i Kliniki Połoznictwa i Chorób Kobiecych AM w Bydgoszczy.
Fórmaniak
Jacek
J
Szymański
Marek
M
Grabiec
Marek
M
D000328:Adult; D000368:Aged; D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000032:analysis*; D000071063:Endoglin; D016889:Endometrial Neoplasms / Q000098:blood supply* / Q000175:diagnosis / Q000276:immunology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008833:Microcirculation; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis*; D011044:Poland; D011237:Predictive Value of Tests; D011379:Prognosis; D011956:Receptors, Cell Surface; D012189:Retrospective Studies; D012307:Risk Factors; D019010:Vascular Cell Adhesion Molecule-1 / Q000032:analysis*
D015703:Antigens, CD; D014408:Biomarkers, Tumor; C064206:ENG protein, human; D000071063:Endoglin; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D011956:Receptors, Cell Surface; D019010:Vascular Cell Adhesion Molecule-1