title: Microvascular density in chronic pancreatitis and pancreatic ductal adenocarcinoma.
abstract: Chronic pancreatitis and pancreatic adenocarcinoma represent two pathologic phenomena with marked production of connective tissue stroma containing numerous small blood vessels. The aim of this study was to characterise quantitatively the vascular supply of pancreatic adenocarcinoma and fragments of the periductal tissue collected from patients with chronic pancreatitis. The study material included 18 cases of pancreatitis and 22 cases of pancreatic ductal adenocarcinoma. Microvessels were marked using monoclonal anti-CD34 antibodies. The number of blood vessels in the fibrous stroma was significantly higher in the chronic pancreatitis samples compared to the pancreatic carcinoma group (mean vessel count 298 and 194 vessel/mm2; median 251 and 187 vessel/mm2 respectively; p<0.01). Distributions of the vascular diameter in both studied groups were very similar. The obtained results suggest that the development of vascular network accompanying chronic pancreatitis is more effective in some parts of pancreas compared to angiogenic intensity in pancreatic adenocarcinoma.
authors.affiliation: Department of Pathomorphology, Medical University, Gdańsk, Poland. rzepko@amedec.amg.gda.pl
authors.forename: Robert
authors.initials: R
authors.lastname: Rzepko
authors.forename: Kazimierz
authors.initials: K
authors.lastname: Jaśkiewicz
authors.forename: Monika
authors.initials: M
authors.lastname: Klimkowska
authors.forename: Adam
authors.initials: A
authors.lastname: Nałecz
authors.forename: Ewa
authors.initials: E
authors.lastname: Izycka-Swieszewska
mesh_terms: D001808:Blood Vessels / Q000473:pathology / Q000503:physiopathology; D021441:Carcinoma, Pancreatic Ductal / Q000098:blood supply* / Q000473:pathology* / Q000503:physiopathology; D002908:Chronic Disease; D003238:Connective Tissue / Q000098:blood supply / Q000473:pathology; D006801:Humans; D008833:Microcirculation / Q000473:pathology* / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000473:pathology* / Q000503:physiopathology; D010190:Pancreatic Neoplasms / Q000098:blood supply* / Q000473:pathology* / Q000503:physiopathology; D010195:Pancreatitis / Q000473:pathology* / Q000503:physiopathology; D012039:Regional Blood Flow / Q000502:physiology; D017154:Stromal Cells / Q000473:pathology