Association of cholesteryl ester transfer protein activity and TaqIB polymorphism with lipoprotein variations in Japanese subjects.
Cholesteryl ester transfer protein (CETP) facilitates the transfer of cholesteryl ester from high-density lipoprotein (HDL) to apolipoprotein (apo)B-containing lipoproteins, whereby it potentially regulates steady-state concentrations of HDL-cholesterol (HDL-C), as well as low-density lipoprotein-cholesterol (LDL-C). We performed a multicenter trial to assess the association of CETP activity with plasma lipoprotein levels in 591 Japanese subjects. Women had significantly higher CETP activity (15%) and mass (24%) compared to men. For both genders CETP activity was negatively correlated with HDL-C and HDL(2)-C, but positively correlated with LDL-C. B2 allele frequency in TaqIB polymorphism was 40%, with no gender difference. TaqIB genotypes were significantly associated with CETP activity and HDL-C level (both P <.001). B1B1 had the highest CETP activity and the lowest HDL-C concentrations, whereas B2B2 had the lowest CETP activity and the highest HDL-C concentrations. However, no statistically significant differences in triglycerides (TG) or LDL-C were observed across TaqIB genotypes. Multivariate analysis revealed that determinants of HDL-C were age, gender, body mass index (BMI), smoking, alcohol intake, exercise, CETP activity, and TG, and for LDL-C were BMI, age, and CETP. These data demonstrate that CETP activity is a significant determinant of HDL-C and LDL-C levels and that TaqIB CETP gene polymorphism affects CETP activity and HDL-C level in Japanese population examined.
Ikewaki
Katsunori
K
Department of Cardiology, Jikei University School of Medicine, Tokyo, Japan.
Mabuchi
Hiroshi
H
Teramoto
Tamio
T
Yamada
Nobuhiro
N
Oikawa
Shinichi
S
Sasaki
Jun
J
Takata
Kouki
K
Saito
Yasushi
Y
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000378:metabolism; D001053:Apolipoproteins / Q000097:blood; D015992:Body Mass Index; D002352:Carrier Proteins / Q000378:metabolism*; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL / Q000097:blood; D015444:Exercise / Q000502:physiology; D005260:Female; D006023:Glycoproteins; D006801:Humans; D007564:Japan; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D012907:Smoking / Q000378:metabolism
D001053:Apolipoproteins; C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D006023:Glycoproteins; D008055:Lipids; D008074:Lipoproteins