title: Effect of pregnancy and menopause on facial wrinkling in women.
abstract: Women appear to be at greater risk of developing wrinkles with age than men. To evaluate the effect of pregnancy and menopause on facial wrinkling, a total of 186 Korean women volunteers aged between 20 and 89 years were interviewed for information on menstrual and reproductive factors. An 8-point photographic scale developed for assessing the severity of wrinkles in Asian skin was used. Cumulative sun exposure, both occupational and recreational, was estimated. In Korean women, the risk of facial wrinkling increases significantly with increasing number of full-term pregnancies (OR = 1.835, 95% confidence interval (CI) 1.017-3.314) and menopausal age (number of years since menopause) (OR = 3.909, 95% CI 1.071-14.275), while hormone replacement therapy is associated with a significantly lower risk for the development of facial wrinkling in postmenopausal women (OR = 0.221, 95% CI 0.047-0.949). Hypo-oestrogenism may play a part in the decrease of skin collagen leading to skin wrinkling in postmenopausal women.
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Choon Shik
authors.initials: CS
authors.lastname: Youn
authors.forename: Oh Sang
authors.initials: OS
authors.lastname: Kwon
authors.forename: Chong Hyun
authors.initials: CH
authors.lastname: Won
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Hwang
authors.forename: Byung Joo
authors.initials: BJ
authors.lastname: Park
authors.forename: Hee Chul
authors.initials: HC
authors.lastname: Eun
authors.forename: Jin Ho
authors.initials: JH
authors.lastname: Chung
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D016001:Confidence Intervals; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D007723:Korea; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D016017:Odds Ratio; D010298:Parity; D011247:Pregnancy / Q000502:physiology*; D011336:Probability; D012307:Risk Factors; D012680:Sensitivity and Specificity; D015595:Skin Aging / Q000502:physiology*; D013472:Sunlight / Q000009:adverse effects