title: 3-(4-Aminobutyn-1-yl)pyridines: binding at alpha 4 beta 2 nicotinic cholinergic receptors.
abstract: The binding of a series pyridylbutynylamines 6 was examined at alpha4beta2 nACh receptors. Structural modifications, comparing 6 with pyridyl ethers 2, did not consistently result in parallel effects on receptor affinity, suggesting possible differences in their modes of binding. Furthermore, the binding of amine 6a seemed to be accounted for by the newer vector pharmacophore models.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, VA 23298-0540, Richmond, USA.
authors.forename: Deniz
authors.initials: D
authors.lastname: Dogruer
authors.forename: Mase
authors.initials: M
authors.lastname: Lee
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Dukat
authors.forename: M Imad
authors.initials: MI
authors.lastname: Damaj
authors.forename: Billy R
authors.initials: BR
authors.lastname: Martin
authors.forename: Richard A
authors.initials: RA
authors.lastname: Glennon
mesh_terms: D000818:Animals; D000440:Butanols; D002531:Cerebellum / Q000378:metabolism; D011485:Protein Binding / Q000502:physiology; D011725:Pyridines / Q000737:chemistry* / Q000378:metabolism*; D051381:Rats; D011978:Receptors, Nicotinic / Q000378:metabolism*
chemical_list: D000440:Butanols; D011725:Pyridines; D011978:Receptors, Nicotinic; C403531:nicotinic receptor alpha4beta2; C021965:3-butyn-1-ol