title: [Chromosome Y microdeletions in Czech men with severe reproductive disorders].
abstract: BACKGROUND
  The Y chromosome microdeletions belong to the frequent genetical causes of male infertility. The aim of our study was to introduce reliable molecular genetic diagnosis of Y chromosomal microdeletions and to determine the prevalence of Y chromosomal microdeletions in Czech males with serious reproductive disorders.
  
  
  RESULTS
  The Y chromosome microdeletions were screened in 198 Czech men with serious reproductive disorders with decreased sperm count. The Y chromosome microdeletions were disclosed in 8/198 (4.0%) examined males. The AZFc deletion type was revealed in 62.5% (5/8) and the combined AZFc + b microdeletion in 37.5% (3/8) of cases. Neither isolated AZFb nor AZFa microdeletion were found in any subject of the investigated group.
  
  
  CONCLUSIONS
  Incidence of individual types of Y chromosomal microdeletions in Czech males with serious reproductive disorders was assessed. The standardised molecular genetic diagnosis of Y chromosomal microdeletions was introduced into the practice.
authors.affiliation: Ustav biologie a lékarské genetiky 2. LF UK a FNM, Praha. katarina.machatkova@lfmotol.cuni.cz
authors.forename: M
authors.initials: M
authors.lastname: Machatková
authors.forename: A
authors.initials: A
authors.lastname: Krebsová
authors.forename: I
authors.initials: I
authors.lastname: Smetanová
authors.forename: M
authors.initials: M
authors.lastname: Matĕjcková
authors.forename: S
authors.initials: S
authors.lastname: Vilímová
authors.forename: A
authors.initials: A
authors.lastname: Sobek
authors.forename: M
authors.initials: M
authors.lastname: Macek
mesh_terms: D041322:Chromosomes, Human, Y / Q000235:genetics*; D017353:Gene Deletion; D056426:Genetic Loci; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D009845:Oligospermia / Q000235:genetics; D029589:Seminal Plasma Proteins / Q000235:genetics
chemical_list: D029589:Seminal Plasma Proteins