title: Recent improvements to the PROSITE database.
abstract: The PROSITE database consists of a large collection of biologically meaningful signatures that are described as patterns or profiles. Each signature is linked to documentation that provides useful biological information on the protein family, domain or functional site identified by the signature. The PROSITE web page has been redesigned and several tools have been implemented to help the user discover new conserved regions in their own proteins and to visualize domain arrangements. We also introduced the facility to search PDB with a PROSITE entry or a user's pattern and visualize matched positions on 3D structures. The latest version of PROSITE (release 18.17 of November 30, 2003) contains 1676 entries. The database is accessible at http://www.expasy.org/prosite/.
authors.affiliation: Swiss Institute of Bioinformatics (SIB), CMU, University of Geneva, 1 rue Michel Servet, 1211 Geneva 4, Switzerland. Nicolas.Hulo@isb-sib.ch
authors.forename: Nicolas
authors.initials: N
authors.lastname: Hulo
authors.forename: Christian J A
authors.initials: CJ
authors.lastname: Sigrist
authors.forename: Virginie
authors.initials: V
authors.lastname: Le Saux
authors.forename: Petra S
authors.initials: PS
authors.lastname: Langendijk-Genevaux
authors.forename: Lorenza
authors.initials: L
authors.lastname: Bordoli
authors.forename: Alexandre
authors.initials: A
authors.lastname: Gattiker
authors.forename: Edouard
authors.initials: E
authors.lastname: De Castro
authors.forename: Philipp
authors.initials: P
authors.lastname: Bucher
authors.forename: Amos
authors.initials: A
authors.lastname: Bairoch
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D019295:Computational Biology; D017124:Conserved Sequence; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D011786:Quality Control; D016415:Sequence Alignment; D013329:Structure-Activity Relationship
chemical_list: D011506:Proteins