HCV and HIV binding lectin, DC-SIGNR, is expressed at all stages of HCV induced liver disease.
The process by which hepatitis C virus (HCV) enters cells and the reason for its hepatotropism remain obscure. Recently, the human immunodeficiency virus (HIV) binding lectins, DC-SIGN and DC-SIGNR, were shown to bind HCV. This article reports the expression of DC-SIGN and DC-SIGNR in HCV related liver disease and discusses whether these lectins, in particular DC-SIGNR, are responsible for HCV hepatotropism.
Cole
G
G
Coleman
N
N
Soilleux
E
E
D015815:Cell Adhesion Molecules / Q000378:metabolism*; D018450:Disease Progression; D006526:Hepatitis C / Q000378:metabolism*; D006801:Humans; D037181:Lectins, C-Type / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin; C433029:CLEC4M protein, human