title: [The influence of habitual cigarette smoking on level of endogenic histamine determined simultaneously in plasma, gastric juice and gastric mucosa in healthy individual].
abstract: The aim of this study was to examine the amount of endogenic histamine measured simultaneously in the plasma, gastric juice and gastric mucosa in habitual smokers and nonsmokers and to suggest possible implications of the obtained results.
  
  
  METHODS
  48 individuals were selected for this test. None of them suffered from any symptoms of ulcer disease. 28 were habitual cigarette smokers, 20 were nonsmokers who had never smoked. The tests were carried out standard conditions. Each patient underwent endoscopy. Gastric juice was taken by catheter via endoscopes, and biopsy specimens were taken for microscopic examination and establish histamine levels, which were also measured in plasma. Blood samples were taken before endoscopy.
  
  
  RESULTS
  The levels of endogenic histamine in plasma and gastric juice were significantly higher in habitual smokers than in nonsmokers, especially in plasma. In the tissue of both groups no statistically significant differences were observed, but the histamine level was slightly higher in nonsmokers.
  
  
  CONCLUSIONS
  The amount of histamine in plasma, as well in gastric juice, is may be connected with habitual cigarette smoking, and its level in tissue may also depend on smoking.
authors.affiliation: Katedra i Klinika Chorób Wewnetrznych i Medycyny Fizykalnej w Bytomiu Sl. AM w Katowicach.
authors.forename: Anna
authors.initials: A
authors.lastname: Gadowska-Cicha
authors.forename: Aleksander
authors.initials: A
authors.lastname: Sieroń
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005750:Gastric Juice / Q000737:chemistry*; D005753:Gastric Mucosa / Q000737:chemistry*; D006184:Habits; D006304:Health Status; D006632:Histamine / Q000032:analysis / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000097:blood*
chemical_list: D006632:Histamine