title: Mepivacaine alters vascular responsiveness to vasoconstrictors in aortic rings from normal and aortic-banded rats.
abstract: The present study investigated the effects of mepivacaine on the response of rat aorta to vasoconstrictors in normal and aortic-banded animals. Cardiac hypertrophy was induced in Wistar rats by aortic banding, while sham-operated animals served as controls. Isolated aortic rings with or without endothelium were contracted with potassium chloride and phenylephrine in the presence of mepivacaine (10(-3) M). Maximal tension was measured at the highest concentration of potassium chloride and phenylephrine. Maximal response to potassium chloride was reduced in the presence of mepivacaine both in normal and aortic-banded rings. As regards the vascular reactivity to phenylephrine, aortic rings with intact endothelium from aortic-banded rats have shown increased response as compared to normal. After mepivacaine administration this difference between normal and aortic-banded rats was abolished. In conclusion, in a model of cardiac hypertrophy such as that of aortic-banding, increased response to alpha1-adrenergic stimulation is observed, which is blunted by mepivacaine administration.
authors.affiliation: Department of Pharmacology, Medical School, University of Athens, 75 Mikras Asias Ave., 11527 Goudi, Athens, Greece.
authors.forename: Constantinos
authors.initials: C
authors.lastname: Mourouzis
authors.forename: Constantinos
authors.initials: C
authors.lastname: Pantos
authors.forename: Iordanis
authors.initials: I
authors.lastname: Mourouzis
authors.forename: Theodosios
authors.initials: T
authors.lastname: Saranteas
authors.forename: Christina
authors.initials: C
authors.lastname: Tesseromatis
authors.forename: Georgia
authors.initials: G
authors.lastname: Kostopanagiotou
authors.forename: Chariclia
authors.initials: C
authors.lastname: Karageorgiou
authors.forename: Dennis
authors.initials: D
authors.lastname: Varonos
authors.forename: Dennis
authors.initials: D
authors.lastname: Cokkinos
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D001011:Aorta; D006332:Cardiomegaly; D003250:Constriction; D004730:Endothelium, Vascular / Q000187:drug effects; D008297:Male; D008619:Mepivacaine / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010656:Phenylephrine / Q000037:antagonists & inhibitors; D011189:Potassium Chloride / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar; D014662:Vasoconstrictor Agents / Q000037:antagonists & inhibitors*
chemical_list: D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D010656:Phenylephrine; D011189:Potassium Chloride; D008619:Mepivacaine