title: A continuous quality-improvement program reduces nosocomial infection rates in the ICU.
abstract: OBJECTIVE
  To assess the impact of a continuous quality-improvement program on nosocomial infection rates.
  
  
  METHODS
  Prospective single-center study in the medical-surgical ICU of a tertiary care center. PATIENTS. We admitted 1764 patients during the 5-year study period (1995-2000); 55% were mechanically ventilated and 21% died. Mean SAPS II was 37+/-21 points and mean length of ICU stay was 9.7+/-16.1 days.
  
  
  METHODS
  Implementation of an infection control program based on international recommendations. The program was updated regularly according to infection and colonization rates and reports in the literature.
  
  
  RESULTS
  Prospective surveillance showed the following rates per 1000 procedure days: ventilator-associated pneumonia (VAP) 8.7, urinary tract infection (UTI) 17.2, central venous catheter (CVC) colonization 6.1, and CVC-related bacteremia and 2.0; arterial catheter colonization did not occur. In the 5 years following implementation of the infection control program there was a significant decline in the rate per patient days of UTI, CVC colonization, and CVC-related bacteremia but not VAP. Between the first and second 2.5-year periods the time to infection increased significantly for UTI and CVC-related colonization.
  
  
  CONCLUSIONS
  A continuous quality-improvement program based on surveillance of nosocomial infections in a nonselected medical-surgical ICU population was associated with sustained decreases in UTI and CVC-related infections.
authors.affiliation: Medical-Surgical Intensive Care Unit, Saint Joseph Hospital, 185 rue Raymond Losserand, 75614 Paris Cedex, France. bmisset@hopital-saint-joseph.org
authors.forename: Benoit
authors.initials: B
authors.lastname: Misset
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Timsit
authors.forename: Marie-Françoise
authors.initials: MF
authors.lastname: Dumay
authors.forename: Maité
authors.initials: M
authors.lastname: Garrouste
authors.forename: Annie
authors.initials: A
authors.lastname: Chalfine
authors.forename: Isabelle
authors.initials: I
authors.lastname: Flouriot
authors.forename: Fred
authors.initials: F
authors.lastname: Goldstein
authors.forename: Jean
authors.initials: J
authors.lastname: Carlet
mesh_terms: D003428:Cross Infection / Q000453:epidemiology / Q000517:prevention & control*; D019983:Guideline Adherence; D006801:Humans; D015994:Incidence; D017053:Infection Control / Q000592:standards*; D007362:Intensive Care Units / Q000592:standards* / Q000706:statistics & numerical data; D010297:Paris / Q000453:epidemiology; D011159:Population Surveillance; D016016:Proportional Hazards Models; D011446:Prospective Studies; D017749:Total Quality Management / Q000379:methods*