Oxidative stress in Caenorhabditis elegans: protective effects of superoxide dismutase/catalase mimetics.
The lifespan of Caenorhabditis elegans can be extended by the administration of synthetic superoxide dismutase/ catalase mimetics (SCMs) without any effects on development or fertility. Here we demonstrate that the mimetics, Euk-134 and Euk-8, confer resistance to the oxidative stress-inducing agent, paraquat and to thermal stress. The protective effects of the compounds are apparent with treatments either during development or during adulthood and are independent of an insulin/IGF-I-like signalling pathway also known to affect thermal and oxidative stress resistance. Worms exposed to the compounds do not induce a cellular stress response and no detrimental effects are observed.
Sampayo
James N
JN
The Buck Institute, 8001 Redwood Boulevard, Novato, CA 94945, USA.
Olsen
Anders
A
Lithgow
Gordon J
GJ
D000375:Aging; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000187:drug effects / Q000378:metabolism; D002374:Catalase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D005029:Ethylenediamines / Q000494:pharmacology; D009942:Organometallic Compounds / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects*; D010269:Paraquat / Q000633:toxicity; D012459:Salicylates / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000975:Antioxidants; C433928:EUK-134; D005029:Ethylenediamines; D009942:Organometallic Compounds; D012459:Salicylates; C090577:N,N'-bis(salicylideneamino)ethane-manganese(II); D002374:Catalase; D013482:Superoxide Dismutase; D010269:Paraquat