title: Polymer-assisted solution phase synthesis of the antihyperglycemic agent Rosiglitazone (Avandia).
abstract: The commercially important antihyperglycemic agent Rosiglitazone 1(Avandia) has been prepared in high purity by a multi-step, polymer-assisted solution phase (PASP) synthesis without the need for the conventional chromatographic purification of any intermediates.
authors.affiliation: Department of Chemistry, University Chemical Laboratory, Lensfield Road, Cambridge, UK CB2 1EW.
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Chris
authors.initials: C
authors.lastname: Abell
authors.forename: Brian H
authors.initials: BH
authors.lastname: Warrington
authors.forename: Mark
authors.initials: M
authors.lastname: Ladlow
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000302:isolation & purification; D008956:Models, Chemical; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry; D000077154:Rosiglitazone; D012996:Solutions / Q000737:chemistry; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000302:isolation & purification
chemical_list: D007004:Hypoglycemic Agents; D011108:Polymers; D012996:Solutions; D045162:Thiazolidinediones; D000077154:Rosiglitazone