Successful treatment of multiple premalignant and malignant lesions in arsenical keratosis with a combination of acitretin and intralesional 5-fluorouracil.
A case of arsenical keratosis with multiple lesions of Bowen's disease and squamous cell carcinoma is described. The patient was successfully treated with a combination of acitretin and intralesional 5-fluorouracil. All the lesions resolved after three months of therapy with no side effects and no recurrence during four months of follow-up.
Khandpur
Sujay
S
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Sharma
Vinod K
VK
D017255:Acitretin / Q000008:administration & dosage*; D001151:Arsenic / Q000009:adverse effects*; D001707:Biopsy, Needle; D001913:Bowen's Disease / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007194:India; D015552:Injections, Intralesional; D007642:Keratosis / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D014873:Water Pollutants / Q000009:adverse effects
D014873:Water Pollutants; D017255:Acitretin; D001151:Arsenic; D005472:Fluorouracil