title: Helix peptide immunoreactivity pattern in the nervous system of juvenile aplysia.
abstract: Distribution of neurons immunopositive to antibody against the small peptides encoded by the Helix Command-Specific 2 (HCS2) gene in the central nervous system of juvenile Aplysia californica was investigated. The HCS2 gene is specifically expressed in the withdrawal behavior neurons of the terrestrial snail Helix lucorum. In Aplysia, 20-25 immunopositive neuronal somata were observed on dorsal surface of each pleural ganglion (including a giant pleural neuron). The HCS2-encoded peptide immunopositive fibers were observed in neuropiles of all ganglia and in many nerves. Functional significance of Aplysia immunopositive cells is discussed.
authors.affiliation: Institute of Higher Nervous Activity and Neurophysiology, 5A Butlerova Str., Moscow 117485, Russia. ierusalimsky@yahoo.com
authors.forename: V N
authors.initials: VN
authors.lastname: Ierusalimsky
authors.forename: D V
authors.initials: DV
authors.lastname: Boguslavsky
authors.forename: A V
authors.initials: AV
authors.lastname: Belyavsky
authors.forename: P M
authors.initials: PM
authors.lastname: Balaban
mesh_terms: D000818:Animals; D001048:Aplysia; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002490:Central Nervous System / Q000166:cytology / Q000378:metabolism*; D017952:Ganglia, Invertebrate / Q000166:cytology / Q000378:metabolism; D015151:Immunoblotting; D007150:Immunohistochemistry / Q000379:methods; D009474:Neurons / Q000378:metabolism; D009479:Neuropeptides / Q000276:immunology / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism
chemical_list: D002135:Calcium-Binding Proteins; C116258:HCS2 protein, Helix lucorum; D009479:Neuropeptides; D011498:Protein Precursors