title: [Incidence of heart defects in Down syndrome].
abstract: Eighty-six patients with Down Syndrome were studied with the main purpose of quantifying the incidence of congenital heart defects and the risk of occurrence according to the mothers age. Thirty-eight patients had the cariotypes determined, 35 of them having trissomy of chromosome 21 and translocation in 3 cases. Congenital heart disease was found in 44 (51%) of the patients, the most common one being ventricular septal defect. An important incidence of Fallot's tetralogy was also found (20%). These 86 children were submitted to 41 surgical procedures, most of them on the cardiovascular system. The maternal mean age was 33 -/+ 8.6 years and the estimated risk of Down Syndrome was 1/590, a lower value than the one reported in other studies.
authors.affiliation: Departmento de Puericultura e Pediatria da FMRPUSP.
authors.forename: J A
authors.initials: JA
authors.lastname: Granzotti
authors.forename: I L
authors.initials: IL
authors.lastname: Paneto
authors.forename: F T
authors.initials: FT
authors.lastname: Amaral
authors.forename: M A
authors.initials: MA
authors.lastname: Nunes