title: MR imaging-guided focused ultrasound surgery of breast cancer: correlation of dynamic contrast-enhanced MRI with histopathologic findings.
abstract: OBJECTIVE
  To assess the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters to monitor residual tumor following non-invasive MRI-guided focused ultrasound surgery (MRIgFUS) of breast tumors.
  
  
  METHODS
  DCE-MRI data were acquired before and after the MRIgFUS treatment of small breast tumors (d < 3.5 cm) for 17 patients. The lesion was surgically resected and the presence of residual tumor was determined by histopathological analysis. The percentage of residual tumor was correlated with three DCE-MRI parameters measured at the maximally enhancing site of each tumor: increase in signal intensity (ISI), maximum difference function (MDF) and positive enhancement integral (PEI).
  
  
  RESULTS
  A good correlation was found between the ISI (r = 0.897), MDF (r = 0.789) and PEI (r = 0.859) parameters and the percentage of residual viable tumor determined by histopathology. A receiver operator characteristic curve analysis yielded a cutoff value for ISI at 20% with a sensitivity of 77% and a specificity of 100%.
  
  
  CONCLUSIONS
  These results suggest that parameters from DCE-MRI data could provide a reliable non-invasive method for assessing residual tumor following MRIgFUS treatment of breast tumors.
authors.affiliation: Département de radiologie, Hôpital Saint-Luc du CHUM, Montreal, Que., Canada.
authors.forename: David
authors.initials: D
authors.lastname: Gianfelice
authors.forename: Abdesslem
authors.initials: A
authors.lastname: Khiat
authors.forename: Mourad
authors.initials: M
authors.lastname: Amara
authors.forename: Assia
authors.initials: A
authors.lastname: Belblidia
authors.forename: Yvan
authors.initials: Y
authors.lastname: Boulanger
mesh_terms: D000368:Aged; D000465:Algorithms; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging / Q000379:methods; D008875:Middle Aged
chemical_list: D003287:Contrast Media