[The NAD(P)H: quinone oxidoreductase 1 C609T polymorphism and susceptibility to esophageal cancer].
OBJECTIVE
To investigate the association of the NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with susceptibility to esophageal squamous cell carcinoma (ESCC) in a northern Chinese population.


METHODS
The NQO1 C609T genotypes were determined by polymerase chain reaction-restriction fragment length polymorphisms (PCR-RFLP) analysis in 193 patients with ESCC and 141 unrelated healthy controls.


RESULTS
The frequency of the T allele (null) among ESCC patients was significantly higher than that among healthy controls (Chi-square=4.86, P=0.028). The NQO1 C/C and C/T genotype distribution among ESCC patients was not significantly different from that among healthy controls (Chi-square= 2.27 and 0.127; P=0.132 and 0.721, respectively). However, the T/T genotype frequency among ESCC patients was significantly higher than that among healthy controls (Chi-square=4.39, P=0.036). The NQO1 T/T genotype significantly increased the risk for developing ESCC, compared to the combination of C/C and C/T genotypes, with the adjusted odds ratio (OR) of 1.81 (95%CI: 1.04-3.15). This increased susceptibility exhibited pronouncedly in patients with family history of upper gastrointestinal cancers (adjusted OR=2.22, 95%CI 1.18-4.17).


CONCLUSIONS
Determination of the NQO1 C609T genotype may be used as a stratification marker to predicate high-risk individuals for ESCC.
Zhang
Jian-hui
JH
Laboratory of Molecular Biology, Hebei Cancer Institute, Shijiazhuang, Hebei, 050011 PR China. jianhuizh@hotmail.com
Li
Yan
Y
Wang
Rui
R
Sarbia
Mario
M
Guo
Wei
W
Wen
Deng-gui
DG
Wei
Li-zhen
LZ
Chen
Zhi-feng
ZF
Kuang
Gang
G
Zhang
Li-wei
LW
He
Ming
M
Wu
Ming-li
ML
Wang
Shi-jie
SJ
D004938:Esophageal Neoplasms / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D011110:Polymorphism, Genetic
D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human