title: HIV and HHV-8 negative primary effusion lymphoma in a patient with hepatitis C virus-related liver cirrhosis.
abstract: Primary effusion lymphoma (PEL) or body cavity-based lymphoma (BCBL) is a unique subgroup of B-cell lymphomas that exhibits exclusive or dominant involvement of serous body cavities without a detectable tumor mass. We present a case of a PEL/BCBL that exclusively involved the peritoneal cavity of a 58-year-old immunocompetent male with hepatitis C virus (HCV)-related liver cirrhosis. The lymphoma cells were large, highly atypical and expressed CD19, CD20, CD22, CD10, HLA-DR, and CD45 with kappa light chain restriction. Unlike typical PEL/BCBL, human herpesvirus type 8/Kaposi sarcoma herpes virus (HHV-8/KSHV) genomic sequence was not present in the lymphoma cells and there was no serologic evidence of human immunodeficiency virus (HIV) infection. This is the fourth reported case of HHV-8 negative, HIV negative PEL/BCBL in a patient with associated HCV-related cirrhosis and review of these cases showed some consistent clinicopathological features, i.e. exclusive involvement of the peritoneal cavity and phenotypic expression of B-cell associated antigens in contrast to the generally null phenotype PEL/BCBL. The occurrence of these cases suggests that HCV may play an etiological role in a subcategory of PEL/BCBL not associated with HHV-8.
authors.affiliation: Department of Pathology, Loyola University Medical Center, Maywood, IL 60153, USA. gpaner@lumc.edu
authors.forename: Gladell P
authors.initials: GP
authors.lastname: Paner
authors.forename: Joanne
authors.initials: J
authors.lastname: Jensen
authors.forename: Kimberly E
authors.initials: KE
authors.lastname: Foreman
authors.forename: Cesar V
authors.initials: CV
authors.lastname: Reyes
mesh_terms: D015658:HIV Infections / Q000821:virology; D018023:HIV Seronegativity / Q000276:immunology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D016174:Hepacivirus / Q000302:isolation & purification*; D006526:Hepatitis C / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D006566:Herpesviridae Infections / Q000821:virology; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D016130:Immunophenotyping; D008103:Liver Cirrhosis / Q000188:drug therapy / Q000821:virology*; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000821:virology*; D008297:Male; D008875:Middle Aged; D016066:Pleural Effusion, Malignant / Q000821:virology*; D010997:Pleural Neoplasms / Q000821:virology*