Oleamide: a member of the endocannabinoid family?
The fatty acid amide class of compounds, which include the endocannabinoid anandamide and the sleep-inducing compound oleamide, have been shown in vitro to have a multiplicity of actions upon different neurochemical systems. In the present issue of this journal, Leggett et al present data indicating that oleamide functionally activates CB(1) cannabinoid receptors in vitro. The significance of their finding is discussed in this commentary.
Fowler
Christopher J
CJ
Department of Pharmacology and Clinical Neuroscience, Umeå University, SE-901 87 Umeå, Sweden. cf@pharm.umu.se
D000818:Animals; D063385:Cannabinoid Receptor Modulators / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D063388:Endocannabinoids; D006801:Humans; D009829:Oleic Acids / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D043884:Receptor, Cannabinoid, CB1 / Q000378:metabolism
D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D009829:Oleic Acids; D043884:Receptor, Cannabinoid, CB1; C029407:oleylamide