Late-onset drug fever associated with minocycline: case report and review of the literature.
A 15-year-old Caucasian boy experienced severe fever, fatigue, and a 40-lb weight loss after 2 years of minocycline therapy. A workup for infectious causes was negative. One week after minocycline discontinuation, the patient reported that his fever had resolved. Two months later, he reported full resolution of symptoms, weight gain, and a return to normal activity. An objective causality assessment indicated that his illness probably was caused by minocycline, which is considered a safe drug; however, it has been associated with rare serious adverse effects. This patient's presentation of fever was noteworthy not only because minocycline is a rare cause of drug fever, but also because of the delayed onset. Clinicians should be aware that minocycline may cause severe fever and illness even after an extended period of drug exposure.
Grim
Shellee A
SA
College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA. sgrim@uic.edu
Romanelli
Frank
F
Jennings
Patricia R
PR
Ofotokun
Ighovwerha
I
D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008911:Minocycline / Q000008:administration & dosage / Q000009:adverse effects*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D008911:Minocycline