Mineralized bone loss in partially edentulous trabeculae of ovariectomized rabbit mandibles.
OBJECTIVE
The purpose of this study was to evaluate trabeculae changes in partially edentulous bone in ovariectomized rabbits.


BACKGROUND
Numerous clinical studies have suggested that the greater risk for oral bone loss in females may be correlated with osteoporosis after menopause. Knowledge of trabecular changes in partially edentulous bone in animals with loss of ovarian function may be beneficial in the diagnosis and treatment of partially edentulous patients of postmenopausal women.


METHODS
Twelve adult female Japanese white rabbits were examined. The mandibular incisors were initially extracted to simulate the partially edentulous bone. Six animals were bilaterally ovariectomized and the other six sham-ovariectomized 12 weeks after tooth extraction. The partially edentulous parts of distal mandibular bodies were processed undecalcified 12 weeks after ovariectomized or sham-ovariectomized surgeries and examined by quantitative trabecular bone histomorphometry.


RESULTS
In ovariectomized rabbits, there were significant increases in trabecular separation, osteoid volume, osteoid thickness, osteoid width, eroded surface, and mineral apposition rate, and a significant decrease in trabecular number.


CONCLUSIONS
The results of sparser trabecular structure, more trabecular osteoid, and increased trabecular bone turnover demonstrate mineralized bone loss in partially edentulous trabeculae of ovariectomized rabbit mandibles and suggest that the same loss may occur in postmenopausal women.
Cao
T
T
Faculty of Dentistry, National University of Singapore, National University Hospital, 119074. dencaot@nus.edu.sg
Shirota
T
T
Ohno
K
K
Michi
K I
KI
D000704:Analysis of Variance; D000818:Animals; D015519:Bone Density / Q000502:physiology; D001857:Bone Matrix / Q000473:pathology; D001862:Bone Resorption / Q000503:physiopathology; D005260:Female; D007576:Jaw, Edentulous, Partially / Q000150:complications* / Q000503:physiopathology; D008336:Mandibular Diseases / Q000209:etiology* / Q000503:physiopathology; D010012:Osteogenesis / Q000502:physiology; D010052:Ovariectomy; D010053:Ovary / Q000502:physiology; D011817:Rabbits; D012307:Risk Factors