Structure investigation of TiIV-BODOLates involved in the catalytic asymmetric reduction of ketones using catecholborane.
The complexes formed by the reaction of [Ti(OiPr)(4)] and bicyclo-octanediols (BODOLs) 1 and 2 (1:1) are useful as chiral catalysts in asymmetric reductions and were investigated by (1)H NMR spectroscopy and computational methods. A consistent picture emerged of head-to-tail dimers being kept together via a Ti-O-Ti-O micro-oxo bridge similar to the Ti-tartrates but different from the corresponding Ti-BINOLates and Ti-TADDOLates.
Sarvary
Ian
I
Department of Organic and Bioorganic Chemistry, Centre for Chemistry and Chemical Engineering, Lund University, P.O. Box 124, 221 00 Lund, Sweden.
Norrby
Per-Ola
PO
Frejd
Torbjörn
T