Mapping individual brains to guide restorative therapy after stroke: rationale and pilot studies.
Some treatments under development to improve motor outcome after stroke require information about organization of individual subject's brain. The current study aimed to characterize normal inter-subject differences in localization of motor functions, and to consider these findings in relation to a potential treatment of motor deficits after stroke. Functional MRI (fMRI) scanning in 14 subjects examined right index finger tapping, shoulder rotation, or facial movement. The largest activation cluster in left sensorimotor cortex was identified for each task, and its center expressed in Talairach stereotaxic coordinates. Across subjects, each task showed considerable variability in activation site coordinates. For example, during finger tapping, the range for center of activation was 7 mm in the x-axis, 19 mm in the y-axis, and 11 mm in the z-axis. The mean value for center of activation was significantly different for all three coordinates for all pairwise task comparisons. However, the distribution of activation site centers for the finger task overlapped with the other two tasks in the x- and y-axes, and with the shoulder task in the z-axis. On average, the center of activation for the three motor tasks were spatially separated and somatotopically distributed. However, across the population, there was considerable overlap in the center of activation site, especially for finger and shoulder movements. Restorative therapies that aim to target specific body segments, such as the hand, in the post-stroke motor system may need to map the individual brain rather than rely on population averages. Initial details are presented of a study using this approach to evaluate such a therapy.
Cramer
Steven C
SC
University of California, Irvine, Department of Neurology, UCI Medical Center, 101 The City Drive South, Building 53, Room 203, Orange, CA 92868-4280, USA. scramer@uci.edu
Benson
Randall R
RR
Burra
Vijaya C
VC
Himes
David
D
Crafton
Kit R
KR
Janowsky
Jeri S
JS
Brown
Jeffrey A
JA
Lutsep
Helmi L
HL
D000368:Aged; D001931:Brain Mapping; D005145:Face / Q000502:physiology; D005260:Female; D005385:Fingers / Q000502:physiology; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D009048:Motor Skills / Q000502:physiology*; D010865:Pilot Projects; D020127:Recovery of Function; D012782:Shoulder / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology; D020521:Stroke / Q000503:physiopathology*; D000071939:Stroke Rehabilitation