[Results of radiotherapy in patients with stage-II Hodgkin's lymphoma with mediastinal lymph node involvement].
Depending on size of intrathoracic lymph nodes, 65 patients with Hodgkin's disease (stage II) were divided into two groups using the mediastinal-thoracic index (MTI): MTI = 0.22-0.3 prior to irradiation and MTI (0.3. Mediastinal nodes showed complete regression immediately after therapy (34-49 Gy aimed at mediastinum) in 12.3% only. In 44 patients (67.6%), complete response was not observed until 3-6 months after treatment, sometimes 24 months. Tumor recurred outside area of exposure 2-4 years in 4 (10.8%) in group I and 2 (7%) in group II (p(3.841). No correlation between recurrence rates and intrathoracic lymph node size was established. 10-year survival in both groups was 89.1 and 92.8%, respectively.
Il'in
N V
NV
Central Research Institute of Roentgeno-Radiology, Ministry of Health of the RF, St. Petersburg.
Kovryzhkina
T A
TA
Akimov
A A
AA
Loviagin
E V
EV
Shenderova
I A
IA
D000328:Adult; D005260:Female; D006689:Hodgkin Disease / Q000473:pathology* / Q000532:radiotherapy*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome