title: Breath-odor evaluation by detection of volatile sulfur compounds--correlation with organoleptic odor ratings.
abstract: Volatile sulfur compounds are known to be major contributors to oral malodor, and their detection by gas chromatography (GC) is a commonly used method for evaluating breath odor in clinical trials. A custom-designed breath-sampling GC system was developed for this purpose. A clinical study was performed to compare the performance of this instrumental method to organoleptic evaluation by trained odor judges. A statistically significant correlation was found between the measured levels of volatile sulfurs and the ratings of the odor judges. Both methods performed similarly in evaluating the breath-freshening effects of two test products. These results demonstrate the strength of the GC method for evaluating breath odor and predicting the breath-freshening effects of oral-care products.
authors.affiliation: Colgate-Palmolive Company Technology Center, Piscataway, New Jersey, USA.
authors.forename: Catherine M
authors.initials: CM
authors.lastname: Hunter
authors.forename: Hollandra P
authors.initials: HP
authors.lastname: Niles
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Lenton
authors.forename: Georgia J
authors.initials: GJ
authors.lastname: Majerus
authors.forename: Joe
authors.initials: J
authors.lastname: Vazquez
authors.forename: Clifford
authors.initials: C
authors.lastname: Kloos
authors.forename: Ravi
authors.initials: R
authors.lastname: Subramanyam
authors.forename: Malcolm I
authors.initials: MI
authors.lastname: Williams
authors.forename: Diane
authors.initials: D
authors.lastname: Cummins
mesh_terms: D000328:Adult; D001944:Breath Tests / Q000379:methods*; D002849:Chromatography, Gas; D004311:Double-Blind Method; D006209:Halitosis / Q000628:therapy*; D006801:Humans; D008875:Middle Aged; D018709:Statistics, Nonparametric; D013457:Sulfur Compounds / Q000032:analysis*
chemical_list: D013457:Sulfur Compounds