title: [Time-effect and dose-effect relationships study on the effect of benefiting-bone capsule on osteoblasts proliferation].
abstract: OBJECTIVE
  To investigate the effect of rats sera containing Benefiting-bone Capsule (BBC) on the cell proliferation of skull osteoblast in neonatal SD rats.
  
  
  METHODS
  Forty female SD rats, aged 12 months, were randomly divided into 4 groups including N.S. group, low dosage, middle dosage and high dosage BBC group, the sera were obtained at different times. MTT method was used to determine the effect of BBC on osteoblasts proliferation.
  
  
  RESULTS
  The MTT value reached its highest point 1.5 hours after oral administration (P < 0.05). MTT of high dosage BBC met the maximum value with the concentration of 25% (P < 0.05).
  
  
  CONCLUSIONS
  The rats sera containing BBC can promote proliferation of osteoblast.
authors.affiliation: Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000.
authors.forename: Xiaochun
authors.initials: X
authors.lastname: Shu
authors.forename: Ronghua
authors.initials: R
authors.lastname: Zhang
authors.forename: Keping
authors.initials: K
authors.lastname: Peng
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Zhu
authors.forename: Yu
authors.initials: Y
authors.lastname: Cai
mesh_terms: D000818:Animals; D002214:Capsules; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D010006:Osteoblasts / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal