title: Hereditary kidney cancer.
abstract: Significant advances have been made in the understanding of the genetic basis of familial renal neoplasia. Identification of key genes in the pathogenesis of various hereditary renal cancer syndromes has provided opportunities to screen family members at risk and to explore the significance of these genetic abnormalities in the development and genesis of much more common sporadic counterparts. As researchers continue to delineate critical carcinogenic pathways and accumulate expansive knowledge on oncogenic mechanisms driving cancer initiation and progression at the cellular and molecular levels, this information will be integrated and translated into effective diagnostic and therapeutic strategies that will dictate clinical management of all renal cancers.
authors.affiliation: Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bldg#10, Room 2B47, Bethesda, MD 20892, USA.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Hwang
authors.forename: Edward M
authors.initials: EM
authors.lastname: Uchio
authors.forename: W Marston
authors.initials: WM
authors.lastname: Linehan
authors.forename: McClellan M
authors.initials: MM
authors.lastname: Walther
mesh_terms: D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D014402:Tuberous Sclerosis / Q000235:genetics; D006623:von Hippel-Lindau Disease