title: Lipid oxidation kinetics in hemodialysis patients with and without history of myocardial infarction.
abstract: BACKGROUND
  In lipid oxidation kinetics studies, prevalent cardiovascular disease has been associated with shortened lag phase, the length of time preceding the onset of oxidation.
  
  
  OBJECTIVE
  To examine, in vitro, copper-induced lipid oxidation kinetics in unfractionated serum from hemodialysis patients and to determine differences in kinetic parameters between patients with and without a history of CVD.
  
  
  METHODS
  Of the 76 patients enrolled in a study of oxidative stress in hemodialysis (44/76 with prevalent CVD, 53/76 males), 9 males with a history of myocardial infarction were selected and matched for age, diabetes and smoking status with 9 males from the non-CVD group. The kinetics of lipid oxidation was studied. Blood chemistry determinations including serum lipids, lipoproteins, hemostatic factors and serum malondialdehyde were obtained. Variables were compared using the t-test for independent samples with history of MI entered as the categorical variable.
  
  
  RESULTS
  Tmax, the oxidation kinetic parameter defined as the time at which the rate of absorbing product accumulation was maximal, was significantly shorter in dialysis patients with a history of MI than in those without (115.2 +/- 38.5 vs. 162.7 +/- 48.9 minutes, P = 0.04). Further, Tmax and MDA were negatively correlated to one another (r = -0.47, P = 0.04). Odds ratios indicate that each 1 minute increase in Tmax was associated with a 3% decrease in odds that a subject had a history of MI.
  
  
  CONCLUSIONS
  These findings indicate the presence of increased oxidative stress in hemodialysis patients with a history of MI.
authors.affiliation: Epidemiology Unit, Brunner Institute of Medical Research, Wolfson Medical Center, Holon, Israel. mboaz8@yahoo.com
authors.forename: Mona
authors.initials: M
authors.lastname: Boaz
authors.forename: Shmuel
authors.initials: S
authors.lastname: Smetana
authors.forename: Zipora
authors.initials: Z
authors.lastname: Matas
authors.forename: Ariella
authors.initials: A
authors.lastname: Bor
authors.forename: Ilya
authors.initials: I
authors.lastname: Pinchuk
authors.forename: Menachem
authors.initials: M
authors.lastname: Fainaru
authors.forename: Manfred S
authors.initials: MS
authors.lastname: Green
authors.forename: Dov
authors.initials: D
authors.lastname: Lichtenberg
mesh_terms: D016022:Case-Control Studies; D003300:Copper / Q000494:pharmacology*; D003430:Cross-Sectional Studies; D006801:Humans; D007700:Kinetics; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D018384:Oxidative Stress; D006435:Renal Dialysis
chemical_list: D003300:Copper