[La accumulation and microstructure change of leg bones of rats fed with La(NO(3))(3) in low dosage for a long term].
OBJECTIVE
To study La accumulation and microstructure change of leg bones of rats fed with La(NO(3))(3) in low dosage for a long term.


METHODS
After the rats were fed by La(NO(3))(3) in dosage of 2 mg x (kg(-1) x d(-1)) for 6 months, the contents of La and Ca,P in the leg bones were determined by ICP MS and spectrophotometry; the microstructure changes of the leg bones were investigated by electron microscopy and X-ray powder diffraction.


RESULTS
In the leg bones of tested rats, the contents of La and P increased greatly, and those of Ca did not change obviously, so that Ca/P ratio values decreased in comparison with the control group.


CONCLUSIONS
La was accumulatied in the rat leg bones and the change of bone microstructure induced after the rats were fed with La(NO(3))(3) in low dosage for a long term.
Li
Rongchang
R
Department of Chemical Biology, Peking University School of Pharmaceutical Science, Beijing 100083, China. PJCLRC@bjmu.edu.cn
Yang
Huiwen
H
Wang
Kui
K
D000818:Animals; D007811:Lanthanum / Q000493:pharmacokinetics* / Q000633:toxicity; D007867:Leg Bones / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D017208:Rats, Wistar
C016534:lanthanide nitrate; D007811:Lanthanum