A chronic myelocytic leukemia case bearing deletions on the three chromosomes involved in a variant t(9;22;11).
Genomic deletions on the derivative chromosomes bearing the reciprocal fusion gene have recently been reported in chronic myelocytic leukemia (CML). We here describe a CML case with a variant rearrangement t(9;22;11)(q34;q11;q13) showing the loss of chromosome 11 sequences in addition to der(9) deletions. Known tumor suppressor genes involved in apoptosis and in the control of cell proliferation were found to be mapped to the lost sequences. Our findings indicate that genomic deletions may occur also on the third derivative chromosome in variant t(9;22).
Anelli
Luisa
L
Sezione di Genetica, Dipartimento di Anatomia Patologica e Genetica, University of Bari, Bari, Italy.
Albano
Francesco
F
Zagaria
Antonella
A
Liso
Arcangelo
A
Roberti
Maria Grazia
MG
Rocchi
Mariano
M
Specchia
Giorgina
G
D002880:Chromosomes, Human, Pair 11; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D017384:Sequence Deletion; D014178:Translocation, Genetic