Fibronectin fragment promotes osteoblast-associated gene expression and biological activity of human osteoblast-like cell.
A fibronectin fragment, which spans from the ninth to tenth type III domain, showed > 95% biological activity in promoting osteoblast adhesion, proliferation and differentiation level compared with those of native fibronectin (FN) molecule. This suggests that the FN type III ninth-tenth domain fragment serves a good substitute for native FN in biomimetic application for osteogenesis.
Kim
Tae-Il
TI
Intellectual Biointerface Engineering Center, College of Dentistry, Seoul National University, 28-1 Yongon-Dong, Chongno-Ku, Seoul 110-749, South Korea.
Jang
Jun-Hyeog
JH
Chung
Chong-Pyoung
CP
Ku
Young
Y
D032701:Biomimetics / Q000379:methods; D002448:Cell Adhesion / Q000187:drug effects / Q000502:physiology; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D005353:Fibronectins / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000502:physiology*; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology*; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D023822:Tissue Engineering / Q000379:methods*
D005353:Fibronectins; D010446:Peptide Fragments