Essential genes that regulate apoptosis.
The expression of several genes has been associated with the induction of apoptosis in a wide variety of vertebrate and invertebrate organisms. However, relatively few gene products have been demonstrated to be required for cell death. This review highlights genes that are required for apoptosis and proposes mechanisms by which the proteins encoded by these genes might function.
Osborne
B A
BA
Department of Veterinary Sciences, Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA.
Schwartz
L M
LM