title: [Interleukin-18 and its related cytokines in plasma of patients with idiopathic thrombocytopenic purpura].
abstract: To explore the role of immune regulating cytokines in pathogenesis of the idiopathic thrombocytopenic purpura (ITP) and its clinical significance, the levels of IL-18, TNF-alpha and Sc5b-9 in plasma of 32 ITP patients and 18 normal individuals were detected using ELISA methods. The results showed that IL-18, TNF-alpha and sC5b-9 levels in plasma of ITP patients were higher than that in normal individuals. The level of IL-18 was positively correlated with the levels of TNF-alpha and sC5b-9. In conclusion, The rising levels of the IL-18, TNF-alpha and sC5b-9 were correlated with disorder of Th1/Th2 subsets, and may contribute to the immune dysfunction in ITP patients. The dynamic observation of these cytokines may be useful in directing the clinical treatment for ITP patients.
authors.affiliation: Department of Hematology, The First People's Hospital of Xuzhou, Xuzhou 221002, China.
authors.forename: Lu-Qin
authors.initials: LQ
authors.lastname: Zhang
authors.forename: Jin-Yuan
authors.initials: JY
authors.lastname: Ge
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Guo
authors.forename: Hui-Ren
authors.initials: HR
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015938:Complement Membrane Attack Complex / Q000032:analysis*; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D015938:Complement Membrane Attack Complex; D020382:Interleukin-18; D014409:Tumor Necrosis Factor-alpha