[Integrin alpha6 beta4 and experimental allergic neuritis].
OBJECTIVE
To explore the relationship between integrins alpha6,beta4 and the process of the injury and repair of the myelin, their expressions in experimental allergic neuritis were analyzed.


METHODS
Experimental allergic neuritis (EAN) models were induced in Lewis rats. The expressions of integrins alpha6 and beta 4 and their receptor laminin, both in the acute phase and recovery phase of EANs, were analyzed by in situ hybridization and immunohistochemistry.


RESULTS
The expression of beta4 decreased in the acute phase P<0.05 and showed no significant changes in the recovery phase(P=0.6840). There were no significant changes of the expression of alpha6 and laminin both in the acute phase and recovery phase of EANs by immunohistochemistry (alpha6 P=0.0751;laminin P=0.2047). The similar results were obtained by in situ hybridization (beta4 in acute phase P<0.05;beta4 in recovery phase P=0.823;alpha6 P= 0.81).


CONCLUSIONS
The expressions of integrins of Schwann cells were affected by inflammation injury, and their patterns of expression were similar to those of integrins alpha6, beta1 and beta4 during embryogenesis. It is inferred that integrin beta4 and the reformation of myelin have a more imitate relationship. The expression changes of alpha6 and beta4 correlate with the injury and repair of myelin during EAN.
Xie
Zhigang
Z
Department of Pathology, Peking University School of Basic Medical Science, Beijing 100083, China. xie_zg@mail.bjmu.edu.cn
Zhong
Yanfeng
Y
Yang
Jinhui
J
Zhang
Qianying
Q
Wang
Shenglan
S
Wang
Wei
W
Guo
Xiaolei
X
D000818:Animals; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D039161:Integrin alpha6beta4 / Q000032:analysis* / Q000235:genetics; D009444:Neuritis, Autoimmune, Experimental / Q000378:metabolism*; D051381:Rats; D011917:Rats, Inbred Lew; D012583:Schwann Cells / Q000737:chemistry
D039161:Integrin alpha6beta4