title: Resuscitation-promoting factors possess a lysozyme-like domain.
abstract: The novel bacterial cytokine family--resuscitation-promoting factors (Rpfs)--share a conserved domain of uncharacterized function. Predicting the structure of this domain suggests that Rpfs possess a lysozyme-like domain. The model highlights the good conservation of residues involved in catalysis and substrate binding. A lysozyme-like function makes sense for this domain in the light of experimental characterization of the biological function of Rpfs.
authors.affiliation: School of Crystallography and BBRSC Centre for Structural Biology, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK.
authors.forename: Martin
authors.initials: M
authors.lastname: Cohen-Gonsaud
authors.forename: Nicholas H
authors.initials: NH
authors.lastname: Keep
authors.forename: Angharad P
authors.initials: AP
authors.lastname: Davies
authors.forename: John
authors.initials: J
authors.lastname: Ward
authors.forename: Brian
authors.initials: B
authors.lastname: Henderson
authors.forename: Gilles
authors.initials: G
authors.lastname: Labesse
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins; D016207:Cytokines / Q000737:chemistry* / Q000235:genetics*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009113:Muramidase / Q000737:chemistry / Q000235:genetics*; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D001426:Bacterial Proteins; D016207:Cytokines; C113704:resuscitation-promoting factor, bacteria; D009113:Muramidase