title: Improvement of ventricular arrhythmia by octreotide treatment in acromegalic cardiomyopathy.
abstract: We report a case of acromegalic cardiomyopathy in a 46-year-old Japanese man with pituitary adenoma. Increased secretion of growth hormone and insulin-like growth factor I were detected. He had left ventricular hypertrophy, impaired cardiac function, and frequent ventricular premature complexes. After 2-month treatment with octreotide, a long-acting somatostatin analogue, levels of both hormones were decreased. At the same time, left ventricular hypertrophy (intraventricular septal thickness: 22.5 to 17.8 mm), cardiac function (ejection fraction: 38 to 50%), and frequency of ventricular premature complexes (17,249 to 2,882 beats a day) were improved. Transsphenoidal surgery was then safely performed. Treatment with octreotide is thought to have some effect on improvement of ventricular arrhythmia in acromegalic heart.
authors.affiliation: Department of Internal Medicine, Yamagata Prefectural Shinjo Hospital, Yamagata, Japan.
authors.forename: Hidetada
authors.initials: H
authors.lastname: Tachibana
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Abe
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sato
authors.forename: Sumito
authors.initials: S
authors.lastname: Inoue
authors.forename: Shuichi
authors.initials: S
authors.lastname: Abe
authors.forename: Michiyasu
authors.initials: M
authors.lastname: Yamaki
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
mesh_terms: D000172:Acromegaly / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D000236:Adenoma / Q000150:complications; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D005117:Cardiac Complexes, Premature / Q000503:physiopathology*; D009202:Cardiomyopathies / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D010911:Pituitary Neoplasms / Q000150:complications; D013004:Somatostatin / Q000819:agonists*; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D019382:Human Growth Hormone; D013004:Somatostatin; D007334:Insulin-Like Growth Factor I; D015282:Octreotide