title: The efficacy and safety of dose escalation of dorzolamide used in combination with other topical antiglaucoma agents.
abstract: We investigated the dose-escalation profile of dorzolamide used in combination with other antiglaucoma agents in patients with primary glaucoma and ocular hypertension. In a prospective, open-label study, 78 patients received dorzolamide 0.5% in addition to other topical antiglaucoma agents for > or =4 weeks. The concentration of dorzolamide was then escalated to 1.0% and intraocular pressure (IOP) measured every 4 weeks for 12 weeks. Dose escalation of dorzolamide from 0.5% to 1.0% resulted in a significant reduction in IOP throughout the 12 weeks of treatment at the higher dose. Mean baseline IOP was 19.7 mmHg. At 4, 8, and 12 weeks after dose escalation, mean IOP had decreased to 17.8 (-9.4%), 17.6 (-10.8%), and 17.5 (-10.7%) mmHg. No serious drug-related adverse effects were reported. These results indicate that dose escalation of dorzolamide from 0.5% to 1.0% is effective and well tolerated as adjunctive therapy for patients in whom IOP is insufficiently controlled by combination therapy.
authors.affiliation: University of Tokyo, Tokyo, Japan. araie-tky@umin.ac.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Araie
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kitazawa
authors.forename: Ikuo
authors.initials: I
authors.lastname: Azuma
authors.forename: Shiroaki
authors.initials: S
authors.lastname: Shirato
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Hamanaka
authors.forename: Goji
authors.initials: G
authors.lastname: Tomita
authors.forename: Hideki
authors.initials: H
authors.lastname: Origasa
mesh_terms: D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D002257:Carbonic Anhydrase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D005901:Glaucoma / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects / Q000502:physiology; D007509:Irritants / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000009:adverse effects; D011446:Prospective Studies; D011453:Prostaglandins / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use; D013449:Sulfonamides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013876:Thiophenes / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000319:Adrenergic beta-Antagonists; D002257:Carbonic Anhydrase Inhibitors; D007509:Irritants; D009883:Ophthalmic Solutions; D011453:Prostaglandins; D013449:Sulfonamides; D013876:Thiophenes; C062765:dorzolamide