Synthesis and antidiabetic activity of some new furochromonyl-2,4-thiazolidinediones.
A new series of furochromone-2,4-thiazolidinedione derivatives (VIIa-h) was prepared by Knoevenagel reaction of substituted-2,4-thiazolidinediones (VIa-h) with Khellin-2-carboxaldehyde (IV). The prepared compounds were tested for their insulinotropic activities in INS-1 cells. Compounds VIId and VIIf (at lower concentration; 1 microgram/ml) were able to increase insulin release in the presence of 5.6 mmol/l glucose. Both these compounds (VIId and VIIf) and VIIg increased glucose uptake in NIH-3T3 cells. Thus these 3 compounds should be tested for antidiabetic effects in vivo.
Bozdağ-Dündar
Oya
O
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandoğan, Ankara, Turkey.
Verspohl
Eugen J
EJ
Waheed
Abdul
A
Ertan
Rahmiye
R
D016475:3T3 Cells; D000818:Animals; D000963:Antimetabolites / Q000378:metabolism; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003847:Deoxyglucose / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007202:Indicators and Reagents; D007328:Insulin / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D045162:Thiazolidinediones / Q000138:chemical synthesis* / Q000494:pharmacology*
D000963:Antimetabolites; D007004:Hypoglycemic Agents; D007202:Indicators and Reagents; D007328:Insulin; D045162:Thiazolidinediones; D003847:Deoxyglucose; D005947:Glucose