BRCA2-RAD51-DSS1 interplay examined from a microbial perspective.
The tumor suppressor BRCA2 plays an essential role in the repair of double-strand DNA breaks by regulating the action of the RAD51 recombinase. The activity of BRCA2 is in turn governed by DSS1, a small acidic protein that appears to function as a necessary cofactor. A model fungal system that reproduces the BRCA2-RAD51 interaction offers the opportunity to understand the mechanism of DSS1 activation at the molecular level.
Kojic
Milorad
M
Department of Microbiology and Immunology, Hearst Microbiology Research Center, Cornell University Weill Medical College, New York, New York 10021, USA.
Holloman
William K
WK
D000818:Animals; D024682:BRCA2 Protein / Q000378:metabolism*; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D007239:Infections / Q000378:metabolism* / Q000382:microbiology*; D011485:Protein Binding; D051135:Rad51 Recombinase
D024682:BRCA2 Protein; D004268:DNA-Binding Proteins; C495153:RAD51 protein, human; D051135:Rad51 Recombinase