[Role of the antioxidative defense system in the pathogenesis of acute viral hepatitides].
OBJECTIVE
To study the activity of antioxidative defense enzymes and the total plasma antioxidative activity in patients with viral hepatitis B, C, and mixed hepatitis B + C.


METHODS
77 patients with viral hepatitis B, 90 with viral hepatitis C, and 25 with mixed hepatitis B + C were followed up. The activity of superoxide dismutase and catalase of leukocytes, and the total plasma antioxidative activity were determined at the peak of the disease, alleviation of clinical symptoms, and before discharge from hospital.


RESULTS
At the peak of the disease, the patients with viral hepatitides showed suppressed activities of superoxide dismutase and catalase of leukocytes and suppressed total plasma antioxidative activity with increased these parameters by early convalescence, but without their normalization. There were the most pronounced changes in patients with severe mixed hepatitis B + C.


CONCLUSIONS
The changes found in the body's antioxidative defense have been ascertained to depend on the etiology, stage, and severity of viral hepatitis.
Nagoev
B S
BS
Ivanova
M R
MR
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002374:Catalase / Q000097:blood / Q000378:metabolism*; D006509:Hepatitis B / Q000201:enzymology / Q000821:virology; D006526:Hepatitis C / Q000201:enzymology / Q000821:virology; D006525:Hepatitis, Viral, Human / Q000097:blood / Q000201:enzymology* / Q000821:virology; D006801:Humans; D007962:Leukocytes / Q000201:enzymology; D008875:Middle Aged; D012720:Severity of Illness Index; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism*
D002374:Catalase; D013482:Superoxide Dismutase