title: Immunosuppressive diterpenes from Veronicastrum sibiricum.
abstract: Two new diterpenes, named sibiriquinone A (1) and B (2), along with four known diterpenes have been isolated from the aerial part of Veronicastrum sibiricum. Their structures were elucidated by spectroscopy. The isolated compounds showed significant immunosuppressive activities.
authors.affiliation: The College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072, China.
authors.forename: Wenyuan
authors.initials: W
authors.lastname: Gao
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takaishi
authors.forename: Hongquan
authors.initials: H
authors.lastname: Duan
mesh_terms: D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008968:Molecular Conformation; D051381:Rats; D028083:Scrophulariaceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004224:Diterpenes; D007166:Immunosuppressive Agents; D003907:Dexamethasone