title: Olanzapine treatment of eight adolescent patients with psychosis.
abstract: Although olanzapine is known as a widely used atypical antipsychotic there have been very few studies about its use in children and adolescents. Eight adolescent patients who were diagnosed as having schizophrenia or schizoaffective disorder, and treated with olanzapine are reported in this case series. The patients were followed-up for 17.5 weeks in the range 4-26 weeks. According to the CGI improvement assessment at the end of the follow-up period, three of eight cases were rated as very much or much improved, three as minimally improved and two as not improved. Olanzapine was well tolerated by the adolescents in this case series except for weight gain. Our results suggest that olanzapine may be an effective antipsychotic for some psychotic adolescents and during olanzapine trials weight gain. Should be monitored.
authors.affiliation: Department of Child and Adolescent Psychiatry, Ege University, Bornova, Izmir, Turkey. eyercan@hotmail.com
authors.forename: Eyup Sabri
authors.initials: ES
authors.lastname: Ercan
authors.forename: Ayşe
authors.initials: A
authors.lastname: Kutlu
authors.forename: Azmi
authors.initials: A
authors.lastname: Varan
authors.forename: Sibel
authors.initials: S
authors.lastname: Cikoğlu
authors.forename: Hakan
authors.initials: H
authors.lastname: Coşkunol
authors.forename: Erhan
authors.initials: E
authors.lastname: Bayraktar
mesh_terms: D000293:Adolescent; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D000077152:Olanzapine; D011618:Psychotic Disorders / Q000188:drug therapy*; D012559:Schizophrenia / Q000188:drug therapy*; D016896:Treatment Outcome; D015430:Weight Gain
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine