Hepatobiliary clearance of labelled mebrofenin in normal and D-galactosamine HCl-induced hepatitis rats and the protective effect of turmeric extract.
This study was carried out to see the hepatobiliary clearance of 99m Tc-Mebrofenin radiopharmaceutical in D-galactosamine induced hepatic rats. Furthermore, protective effect of turmeric extract has been studied in these hepatitis rats. Hepatitis was induced with intraperitoneal injection of D-galactosamine (400 mg/kg b. wt) in these rats. 1% turmeric extract was given along with their normal diet for 15 days. Turmeric extract treatment significantly increased the hepatic uptake of radioactivity and accelerated the excretion of 99m Tc-Mebrofenin as compared to control rats. (P < 0.001). In D-galactosamine administered rats, a significant delay was observed in 99m Tc-Mebrofenin excretion as compared to controls. However, D-galactosamine administered rats, pretreated with turmeric extract or concurrently treated with turmeric extract showed a near normal pattern of 99m Tc-Mebrofenin excretion. Hence, it can be suggested that turmeric extract may improve the liver function by detoxification.
Deshpande
U R
UR
Radiation Medicine Centre (B. A. R. C.), Tata Memorial Hospital Annexe, Parel, Mumbai 400 012.
Joseph
L J
LJ
Samuel
A M
AM
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000378:metabolism; D000814:Aniline Compounds; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001646:Bile / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism* / Q000517:prevention & control*; D030024:Curcuma / Q000737:chemistry*; D005688:Galactosamine; D005998:Glycine; D007098:Imino Acids / Q000493:pharmacokinetics; D007275:Injections, Intravenous; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D000814:Aniline Compounds; D007098:Imino Acids; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D005688:Galactosamine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; C034837:technetium Tc 99m mebrofenin; D005998:Glycine