A Schiff base complex of chromium(III): an efficient inhibitor for the pathogenic and invasive potential of Shigella dysenteriae.
A Schiff base complex of chromium(III), transdiaqua[N,N'ethylenebis (salicylideneimine)chromium(III)]perchlorate, [Cr(salen)(OH(2))(2)](+), was found to have an inhibitory effect on the growth of Shigella dysenteriae. The chromium(III) complex was found to cure (remove) the invasive plasmid and thereby render the microbe more sensitive to the tested antibiotics. The loss in the catalytic activity of the isolated endo-alpha-N-acetyl galactosaminidase on mucin as a substrate was also observed in the presence of [Cr(salen)(OH(2))(2)](+). This suggests that [Cr(salen)(OH(2))(2)](+) is toxic to the microbe and could make the microbe non-pathogenic and non-invasive, thus establishing its role in microbiological applications to reduce the toxic potentials of a microbe.
Shrivastava
H Yamini
HY
Chemical Laboratory, Central Leather Research Institute, Adyar, Chennai 600 020, India.
Devaraj
S Niranjali
SN
Nair
Balachandran Unni
BU
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002857:Chromium / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D012545:Schiff Bases / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D012762:Shigella dysenteriae / Q000187:drug effects* / Q000472:pathogenicity
D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D012545:Schiff Bases; C490230:transdiaqua(N,N'ethylenebis (salicylideneimine)chromium(III))perchlorate; D002857:Chromium