title: Immune response to Abeta-peptides in peripheral blood from patients with Alzheimer's disease and control subjects.
abstract: To investigate the immune response to amyloid beta-peptide (Abeta: Abeta40 and Abeta42) in peripheral human blood, sera were obtained from 36 patients with Alzheimer's disease (AD) and 34 age-matched controls. ELISA assays were used to measure antibody concentrations to Abeta-peptides. T cell response was assessed using a lymphoproliferation assay. Both AD and control subjects had low and variable concentrations of antibodies against Abeta (predominantly IgG1). The mean antibody to Abeta concentrations did not differ between groups. No specific T cell response to Abeta-peptides was detected. Natural levels of antibodies to Abeta in peripheral blood are present in all human subjects and are unlikely to be useful in the identification of patients who would respond to potential AD immune therapy. Specific cellular immune responses to Abeta in human blood were not detected.
authors.affiliation: Epidemiology-Global Medical Affairs, Aventis Pasteur, 2 Avenue Pont Pasteur, 69007 Lyon, France. baril@pasteur.fr
authors.forename: Laurence
authors.initials: L
authors.lastname: Baril
authors.forename: Ludovic
authors.initials: L
authors.lastname: Nicolas
authors.forename: Bernard
authors.initials: B
authors.lastname: Croisile
authors.forename: Pierre
authors.initials: P
authors.lastname: Crozier
authors.forename: Catherine
authors.initials: C
authors.lastname: Hessler
authors.forename: Agnès
authors.initials: A
authors.lastname: Sassolas
authors.forename: Joseph B
authors.initials: JB
authors.lastname: McCormick
authors.forename: Emanuelle
authors.initials: E
authors.lastname: Trannoy
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000097:blood* / Q000276:immunology*; D016229:Amyloid beta-Peptides / Q000097:blood / Q000276:immunology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood / Q000276:immunology*; D018709:Statistics, Nonparametric
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42)