T-cell large granular lymphocytic leukemia occurring after autologous peripheral blood stem cell transplantation.
A 61-year-old man with angioimmunoblastic lymphoma in first complete remission underwent autologous peripheral blood stem cell transplantation. At 1 month post transplant, asymptomatic large granular lymphocytosis developed. The surface marker profile of the cells was CD3+CD8+CD56-CD57+. The disease course was chronic and indolent. The patient remains in complete remission from angioimmunoblastic lymphoma more than 6 months post transplant with persistent large granular lymphocytosis (lymphocyte count, 5-15 x 10(9)/l). Although post transplantation T-cell lymphoproliferative disorders have mostly occurred in allogeneic transplantation recipients and presented as aggressive lymphomas/leukemias, we suggest that chronic indolent T-cell large granular lymphocytic leukemia can occur after autologous stem cell transplantation.
Narumi
H
H
The First Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.
Kojima
K
K
Matsuo
Y
Y
Shikata
H
H
Sekiya
K
K
Niiya
T
T
Bando
S
S
Niiya
H
H
Azuma
T
T
Yakushijin
Y
Y
Sakai
I
I
Yasukawa
M
M
Fujita
S
S
D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000150:complications* / Q000628:therapy; D016130:Immunophenotyping; D007945:Leukemia, Lymphoid / Q000175:diagnosis / Q000209:etiology*; D015458:Leukemia, T-Cell / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D013997:Time Factors; D014182:Transplantation, Autologous