Hypocholesterolemic property of Yucca schidigera and Quillaja saponaria extracts in human body.
This study was undertaken to observe the effects of the blend of partially purified Yucca schidigera and Quillaja saponaria extracts on cholesterol levels in the human's blood and gastrointestinal functions, and to determine if a new cholesterol-lowering drug can be developed by the further purification of the extracts. Ultrafiltration and sequential diafiltration increased the amounts of steroidal saponin in aqueous yucca extract and terpenoid saponin in aqueous quillaja extract from 9.3% and 21.4% to 17.2% and 61.8%, respectively. Taking 0.9 mg of the blend (6:4, v:v) of the resulting filtrates a day for 4 weeks resulted in the decreases in total and LDL cholesterol levels in blood plasma of hyper-cholesterolemic patients with enhancement in gastrointestinal symptoms of patients.
Kim
Sang-Woo
SW
Division of Endocrinology & Metabolism, Department of Medicine, Miz Medi Hospital, Seoul, Korea.
Park
Sang-Kyu
SK
Kang
Sung-Il
SI
Kang
Han-Chul
HC
Oh
Han-Jin
HJ
Bae
Chul-Young
CY
Bae
Dong-Ho
DH
D000924:Anticholesteremic Agents / Q000009:adverse effects / Q000302:isolation & purification / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004311:Double-Blind Method; D004338:Drug Combinations; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008875:Middle Aged; D008517:Phytotherapy / Q000379:methods; D024301:Plant Bark; D010946:Plants, Medicinal / Q000737:chemistry*; D031990:Quillaja; D027623:Yucca
D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D004338:Drug Combinations; D002784:Cholesterol