Mathematical models of HIV and the immune system.
I describe how mathematical models have been used to elucidate the principles which govern HIV and immune system dynamics in relation to antiviral drug therapy. The review starts by introducing a basic model of virus infection and demonstrates how it was used to study HIV dynamics and to measure crucial parameters which lead to a new understanding of the disease process. Since this analysis indicates that eradication of the virus is not feasible during the lifetime of the patient, I continue to discuss mathematical models with the aim to explore how drug therapy can be used to induce long-term immunological control of the infection.
Wodarz
Dominik
D
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP-665, Seattle, WA 98109-1024, USA.
D000486:Allergy and Immunology; D019380:Anti-HIV Agents / Q000627:therapeutic use; D019295:Computational Biology; D006678:HIV / Q000187:drug effects / Q000276:immunology*; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D006801:Humans; D008433:Mathematics; D018448:Models, Immunological
D019380:Anti-HIV Agents