title: Salvage chemotherapy and surgery for radio recurrent carcinoma glottis.
abstract: Chemoradiotherapy is increasingly used in advanced laryngeal cancers. Failures are generally managed by surgery. They include histologically confirmed recurrent or residual disease or a symptomatic life threatening treatment sequelae. Tumour recurrence or residivism can be managed by chemotherapy when radical surgery is either refused by the patient or if the general condition of the patient do not permit it. However surgery becomes inevitable when life threatening treatment sequelae like absolute pharyngo-oesophageal stricture and aspiration sets in.
authors.affiliation: Departments of Surgical Oncology and Radiation Oncology, Regional Cancer Centre, Trivandrum - 695 011, India. bipin@rcctvm.org
authors.forename: B T
authors.initials: BT
authors.lastname: Varghese
authors.forename: K
authors.initials: K
authors.lastname: Ramdas
authors.forename: P
authors.initials: P
authors.lastname: Sebastian
authors.forename: M K
authors.initials: MK
authors.lastname: Nair
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D004940:Esophageal Stenosis / Q000209:etiology / Q000601:surgery; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000601:surgery; D009381:Neoplasms, Radiation-Induced / Q000188:drug therapy* / Q000601:surgery; D016879:Salvage Therapy; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D008727:Methotrexate