[Pharmacokinetics of scutellarin in rabbits].
An RP-HPLC was established to determine scutellarin in rabbit plasma and to study pharmacokinetics of breviscapine in rabbits. The analytical column was DiamonsilTM C18(4.6 mm x 250 mm, 5 microns), the mobile phase consisted of methanol, 0.02 mol/L phosphate buffer(adjusted by phosphoric acid to pH 3.0) and acetonitrile (65:35:10), the flow rate was 1.0 ml.min-1, the column temperature was 25 degrees C and the detection wavelength was 334 nm. The results of the pharmacokinetics study showed that the concentration-time curve of scutellarin was conformed to two-compartment model, the chief pharmacokinetic parameters were as follows: t1/2 alpha 1.29 +/- 0.53 min, t1/2 beta 10.40 +/- 1.97 min, Vc148.1 +/- 118.6 ml, and CL 57.5 +/- 31.7 ml.min-1.
Li
Suhua
S
West China School of Pharmacy, Sichuan University, Chengdu 610041.
Jiang
Xuehua
X
Yang
Qiang
Q
Jin
Zhaohui
Z
D000818:Animals; D047310:Apigenin; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D005965:Glucuronates / Q000097:blood*; D007275:Injections, Intravenous; D008297:Male; D011817:Rabbits
D005419:Flavonoids; D005965:Glucuronates; C061097:breviscapine; C484876:scutellarin; D047310:Apigenin