Effect of Mg2SO4 usage on spinal cord ischemia-reperfusion injury: electron microscopic and functional evaluation.
OBJECTIVE
To evaluate the effects of intravenous magnesium sulfate (Mg(2)SO(4)) administration on ischemia-reperfusion injury of the spinal cord.


METHODS
Sixteen rabbits were randomly assigned to the control (group I, 8 rabbits) and the study group (group II, 8 rabbits). The abdominal aorta was clamped for a period of 30 min followed by a reperfusion period of 60 min. The animals in group II received 0.25 ml/kg/h Mg(2)SO(4) intravenous infusion (15% Mg(2)SO(4)) throughout this procedure. The animals were then observed for 24 h after which their neurological states were evaluated and tissue samples obtained from the spinal cord were examined with electron microscopy.


RESULTS
Aortic pressure distal to the cross-clamp during the occlusion period was 9 +/- 3 mm Hg in group I and 19 +/- 6 mm Hg in group II. All animals in group I were paraplegic at the end of the study. In group II the neurological outcome of 1 animal was poor while the other 7 animals were neurologically in a good condition. Electron microscopic examinations of the spinal cord tissues of group I revealed severe injury but the ultrastructure was well preserved in group II.


CONCLUSIONS
Intravenous Mg(2)SO(4) administration may have protective effects on the ischemia-reperfusion injury of the spinal cord. We propose that Mg(2)SO(4) may be an additional protective pharmacological agent in thoracal and thoracoabdominal aortic surgery.
Kaplan
Sadi
S
Cardiovascular Surgery Clinic, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey.
Ulus
A Tulga
AT
Tütün
Ufuk
U
Aksöyek
Ayşen
A
Ozgencil
Eser
E
Saritaş
Zülfikar
Z
Apaydin
Nusret
N
Pamuk
Kamuran
K
Can
Zeynep
Z
Sürücü
Selçuk
S
Katircioğlu
S Fehmi
SF
D000818:Animals; D001011:Aorta / Q000503:physiopathology; D001794:Blood Pressure; D007275:Injections, Intravenous; D008278:Magnesium Sulfate / Q000008:administration & dosage / Q000494:pharmacology*; D008854:Microscopy, Electron; D009420:Nervous System / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D010264:Paraplegia / Q000209:etiology; D011817:Rabbits; D015427:Reperfusion Injury / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D013116:Spinal Cord / Q000473:pathology / Q000503:physiopathology / Q000648:ultrastructure; D020760:Spinal Cord Ischemia / Q000150:complications / Q000473:pathology* / Q000503:physiopathology
D018696:Neuroprotective Agents; D008278:Magnesium Sulfate