title: Early postoperative body temperature and developmental outcome after open heart surgery in infants.
abstract: BACKGROUND
  Experimental data have suggested that early postoperative temperature management after cerebral ischemia may alter neurologic outcome. We explored whether minor deviations in early postoperative body temperature after infant heart surgery affects developmental outcome.
  
  
  METHODS
  In a study of infants undergoing repair of congenital heart disease, 95% of whom had a period of deep hypothermic circulatory arrest, postoperative temperature data were collected following cardiac surgery. Subjects were infants who had been enrolled in one of two prospective randomized single-center trials. Development was tested at age one year (the Bayley Scales of Infant Development) and at four years (Wechsler Preschool and Primary Scale of Intelligence, including Full Scale IQ, a Verbal IQ, and a Performance IQ).
  
  
  RESULTS
  Perioperative temperature data were reviewed in 329 patients, of whom 244 (74%) were evaluated at age one year and 156 (48%) were evaluated at four years. The temperature profile was recorded during the rewarming phase and for 36 hours postoperatively on the Intensive Care Unit. There were no significant associations between postoperative temperature and any of the neurodevelopmental tests at age one or four years. A further analysis assessing the percentage of time over specific temperature cutoff points of 37.5 degrees C, 38 degrees C, 38.5 degrees C, and 39 degrees C, revealed no significant effect.
  
  
  CONCLUSIONS
  Neurodevelopmental outcome at one and four years after repair of complex congenital heart disease was not significantly affected by the early postoperative body temperature profile of the infant when a management strategy aiming for normothermia is employed.
authors.affiliation: Department of Paediatric Intensive Care, Birmingham Children's Hospital, Steelehouse Lane, B4 6NH, Birmingham, United Kingdom
authors.forename: Serena M
authors.initials: SM
authors.lastname: Cottrell
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Morris
authors.forename: Paul
authors.initials: P
authors.lastname: Davies
authors.forename: David C
authors.initials: DC
authors.lastname: Bellinger
authors.forename: Richard A
authors.initials: RA
authors.lastname: Jonas
authors.forename: Jane W
authors.initials: JW
authors.lastname: Newburger
mesh_terms: D001831:Body Temperature; D002657:Child Development; D002675:Child, Preschool; D005500:Follow-Up Studies; D006324:Heart Arrest, Induced; D006801:Humans; D007223:Infant; D011184:Postoperative Period; D011446:Prospective Studies; D013997:Time Factors