title: Collagen content of nonsupport tissue in pelvic organ prolapse and stress urinary incontinence.
abstract: OBJECTIVE
  Reduction in the collagen content of the pelvic floor tissue of the patients with pelvic organ prolapse and/or stress urinary incontinence has been documented previously. However, this is less clear for nonsupport tissue. We aimed to compare the collagen content of the uterine cervix, a nonsupport tissue, of women who had pelvic organ prolapse with and without stress urinary incontinence against those without these problems.
  
  
  METHODS
  Cervical collagen content was compared between 14 women who had pelvic organ prolapse with and without stress urinary incontinence and 17 controls without these conditions. Specimens were obtained after surgery for benign gynecologic conditions.
  
  
  RESULTS
  Groups were similar with respect to age, parity, body mass index, and tobacco use. Women who had pelvic organ prolapse with and without stress urinary incontinence possessed significantly less collagen compared with the controls (8.10%+/-3.43% vs 12.35%+/-4.72%, P=.0104). Furthermore age, parity, body mass index, or tobacco use had no significant relationship to collagen content.
  
  
  CONCLUSIONS
  Cervical collagen content is significantly decreased in women who have pelvic organ prolapse with and without stress urinary incontinence regardless of age, parity, body mass index, or tobacco use.
authors.affiliation: Department of Obstetrics, Gynecology, and Reproductive Sciences, Temple University School of Medicine, 3401 N. Broad Street, Philadelphia, PA 19140, USA.
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Wong
authors.forename: Ozgur H
authors.initials: OH
authors.lastname: Harmanli
authors.forename: Mehmet
authors.initials: M
authors.lastname: Agar
authors.forename: Vani
authors.initials: V
authors.lastname: Dandolu
authors.forename: M H Terry
authors.initials: MH
authors.lastname: Grody
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D015992:Body Mass Index; D016022:Case-Control Studies; D002584:Cervix Uteri / Q000378:metabolism / Q000473:pathology*; D003094:Collagen / Q000032:analysis*; D046508:Culture Techniques; D005260:Female; D006801:Humans; D016014:Linear Models; D008875:Middle Aged; D010298:Parity; D011336:Probability; D012016:Reference Values; D012307:Risk Factors; D012720:Severity of Illness Index; D012907:Smoking / Q000009:adverse effects; D014550:Urinary Incontinence, Stress / Q000473:pathology / Q000601:surgery*; D013519:Urogenital Surgical Procedures / Q000379:methods; D014596:Uterine Prolapse / Q000473:pathology / Q000601:surgery*
chemical_list: D003094:Collagen