title: A prospective randomised clinical trial of the intra-operative use of 5-fluorouracil on the outcome of dupuytren's disease.
abstract: 5-Fluorouracil reduces proliferation rates of fibroblasts, myofibroblast differentiation and contractility of ocular fibroblasts in vitro. This double-blind randomized clinical trial assesses whether intra-operative topical treatment with 5-fluorouracil reduces the recurrence rate after limited excision of Dupuytren's tissue. Patients with two-digit disease were randomized to having 5-fluorouracil (25mg/ml) treatment for 5 minutes on one digit and placebo on the other. Fifteen patients were enrolled with 18 months follow-up. There were no peri-operative complications. Wound healing was not delayed and there was no deterioration in the flexion deformity of the 5-fluorouracil treated digits. Patients were subsequently assessed by joint angle measurement at 3, 6, 12 and 18 months. There was no significant difference between control and 5-fluorouracil treated digits.
authors.affiliation: From the RAFT Institute of Plastic Surgery, Mount Vernon Hospital, Northwood, HA6 2RN, UK.
authors.forename: N W
authors.initials: NW
authors.lastname: Bulstrode
authors.forename: M
authors.initials: M
authors.lastname: Bisson
authors.forename: B
authors.initials: B
authors.lastname: Jemec
authors.forename: A L
authors.initials: AL
authors.lastname: Pratt
authors.forename: D A
authors.initials: DA
authors.lastname: McGrouther
authors.forename: A O
authors.initials: AO
authors.lastname: Grobbelaar
mesh_terms: D000963:Antimetabolites / Q000627:therapeutic use*; D004311:Double-Blind Method; D004387:Dupuytren Contracture / Q000188:drug therapy* / Q000601:surgery; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D055502:Secondary Prevention; D016896:Treatment Outcome
chemical_list: D000963:Antimetabolites; D005472:Fluorouracil