Effect of Helicobacter pylori eradication on high-density lipoprotein cholesterol.
We examined the effect of Helicobacter pylori (H. pylori) eradication on lipids and apolipoproteins in 87 patients with duodenal ulcers. A significant increase was observed in high-density lipoprotein (HDL) cholesterol (+24.7%, p <0.001), apolipoprotein AI (+9.0%, p <0.001), and apolipoprotein AII (+11.7%, p <0.001) after eradication. Minor increases occurred in total cholesterol, triglycerides, and apolipoprotein B, whereas low-density lipoprotein cholesterol remained unchanged. Our results suggest that chronic H. pylori infection reduces plasma levels of HDL cholesterol and that eradication improves the lipoprotein pattern.
Scharnagl
Hubert
H
Clinical Institute of Medical and Chemical Laboratory Diagnostics, University and General Hospital, University of Graz, Graz, Austria. hubert.scharnagl@klinikum-graz.at
Kist
Manfred
M
Grawitz
Andrea Busse
AB
Koenig
Wolfgang
W
Wieland
Heinrich
H
März
Winfried
W
D016632:Apolipoprotein A-I / Q000097:blood; D016633:Apolipoprotein A-II / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D003327:Coronary Disease / Q000453:epidemiology; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000097:blood / Q000382:microbiology*; D005260:Female; D016481:Helicobacter Infections / Q000097:blood / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012306:Risk; D014280:Triglycerides / Q000097:blood
D016632:Apolipoprotein A-I; D016633:Apolipoprotein A-II; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008074:Lipoproteins; D014280:Triglycerides