Recurrent transverse myelitis associates with anti-Ro (SSA) autoantibodies.
Transverse myelitis (TM) is an idiopathic inflammatory disorder of the spinal cord. The authors observed cases of recurrent TM in patients where anti-Ro (SSA) antibodies were present and therefore performed a case-control study to examine the frequency of anti-Ro autoantibodies in patients with recurrent TM and control subjects. Antibodies to 52-kd Ro were demonstrated in 77% of cases (10/13) compared with only 33% of control subjects (4/12).
Hummers
L K
LK
Department of Medicine, Johns Hopkins University, Baltimore, MD 21224, USA. lhummers@jhmi.edu
Krishnan
C
C
Casciola-Rosen
L
L
Rosen
A
A
Morris
S
S
Mahoney
J A
JA
Kerr
D A
DA
Wigley
F M
FM
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009188:Myelitis, Transverse / Q000175:diagnosis / Q000276:immunology*; D020733:RNA, Small Cytoplasmic; D012008:Recurrence; D012189:Retrospective Studies; D012261:Ribonucleoproteins / Q000276:immunology*; D000099207:SS-A Antigen
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D001324:Autoantigens; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human