title: Effects of da ding feng zhu decoction in 30 cases of liver fibrosis.
abstract: To study the clinical effects of Da Ding Feng Zhu ([symbol: see text]) Decoction on liver fibrosis. 56 patients with liver fibrosis due to chronic hepatitis B were randomly divided into a treatment group (30 cases treated with Da Ding Feng Zhu Decoction) and a control group (26 cases treated with colchicine). The serum levels of hyaluronic acid (HA), procollagen III (PC-III), IV collagen (IV-C) and Laminin (LN) of the patients were determined, compared and analyzed before treatment and after 3-month treatment in the two groups. The results showed that in the treatment group, the levels of HA, PC-III, IV-C and LN after 3-month treatment were significantly lowered as compared to that before treatment (P < 0.01). In the control group, only the HA level was obviously lowered (P < 0.05). There was an significant difference (P < 0.05) in PC-III and IV-C and a very significant difference (P < 0.01) in HA after treatment between the two groups. It is therefore concluded that Da Ding Feng Zhu Decoction can lower serum indexes of liver fibrosis.
authors.affiliation: Taizhou Municipal Hospital of Traditional Chinese Medicine, Zhejiang Province 318000.
authors.forename: Weilin
authors.initials: W
authors.lastname: Li
authors.forename: Caidang
authors.initials: C
authors.lastname: Wang
authors.forename: Junli
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000328:Adult; D024061:Collagen Type III / Q000097:blood; D024141:Collagen Type IV / Q000097:blood; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D007797:Laminin / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy
chemical_list: D024061:Collagen Type III; D024141:Collagen Type IV; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D007797:Laminin; D006820:Hyaluronic Acid