title: Immunoglobulin heavy chain genes somatic hypermutations and chromosome 11q22-23 deletion in classic mantle cell lymphoma: a study of the Swiss Group for Clinical Cancer Research.
abstract: Mantle cell lymphoma (MCL) shares immunophenotypic and karyotypic features with chronic lymphocytic leukaemia. The latter comprises two distinct entities with prognosis dependent upon immunoglobulin heavy chain (IgH) gene mutational status and the presence of 11q deletion. We evaluated the relevance of IgH gene mutational status, IgV gene family usage and presence of 11q deletion in a series of 42 histologically reviewed classical MCL cases to determine the prognostic impact. VH3 was the most common VH family, with VH3-21 being the most frequent individual VH gene. Approximately 30% of the cases had a IgH somatic mutation rate higher than 2%, but was only higher than 4% in <10% of cases. Half of the cases had deletion of chromosome 11q21-telomere (11q21->ter), with two minimal deleted regions, at 11q22.2 and 11q23.2. There was no association between 11q loss and IgH gene somatic mutation rate; the use of VH3-21 gene could be associated with a better prognosis.
authors.affiliation: Experimental Oncology, Oncology Institute of Southern Switzerland, Via Vincenzo Vela 6, Stabile IRB, 6500 Bellinzona, Switzerland. frbertoni@mac.com
authors.forename: Francesco
authors.initials: F
authors.lastname: Bertoni
authors.forename: Annarita
authors.initials: A
authors.lastname: Conconi
authors.forename: Sergio B
authors.initials: SB
authors.lastname: Cogliatti
authors.forename: Shu-Fang Hsu
authors.initials: SF
authors.lastname: Schmitz
authors.forename: Michele
authors.initials: M
authors.lastname: Ghielmini
authors.forename: Thomas
authors.initials: T
authors.lastname: Cerny
authors.forename: Martin
authors.initials: M
authors.lastname: Fey
authors.forename: Gabriella
authors.initials: G
authors.lastname: Pichert
authors.forename: Francesco
authors.initials: F
authors.lastname: Bertolini
authors.forename: Maurilio
authors.initials: M
authors.lastname: Ponzoni
authors.forename: Luca
authors.initials: L
authors.lastname: Baldini
authors.forename: Chris
authors.initials: C
authors.lastname: Jones
authors.forename: Rebecca
authors.initials: R
authors.lastname: Auer
authors.forename: Emanuele
authors.initials: E
authors.lastname: Zucca
authors.forename: Franco
authors.initials: F
authors.lastname: Cavalli
authors.forename: Finbarr E
authors.initials: FE
authors.lastname: Cotter
mesh_terms: D000368:Aged; D002880:Chromosomes, Human, Pair 11; D005260:Female; D017353:Gene Deletion; D005803:Genes, Immunoglobulin; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011379:Prognosis