Is there a role for GPIs in yeast cell-wall assembly?
Glycosylphosphatidylinositol (GPI) membrane anchors are essential for the integration of yeast cell adhesion proteins into the cell wall, but mature cell-wall proteins are unlikely to be attached directly to the membrane. We thus propose that GPI-anchored glycoprotein forms are intermediates in a process that crosslinks the major components of the cell wall by transglycosylation. This mechanism may be critical for both the biosynthesis and overall architecture of the cell wall.
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Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, VT 05405, USA.
Lipke
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