title: Association of angiotensin converting enzyme gene I/D polymorphism of vitiligo in Korean population.
abstract: Vitiligo (leukoderma) is an acquired idiopathic hypomelanotic disorder characterized by the circumscribed depigmented patches. Vitiligo is a polygenic disease. The exact pathogenesis is not yet known. The angiotensin converting enzyme (ACE) gene was selected as a candidate gene as ACE plays an important role in the physiology of the vasculature, blood pressure and inflammation, and its relationship with various diseases, including autoimmune diseases, has been widely investigated. The I/D polymorphism of ACE gene in vitiligo patients has not been reported. In this study, we investigated ACE gene polymorphism in 120 vitiligo patients and in 429 healthy volunteers in Korea. The ACE gene genotype distribution (P = 0.032) and allele frequency (P = 0.012) were significantly different between vitiligo patients and healthy controls. This study suggests that the ACE gene polymorphism has a strong association with the development of vitiligo in Korean patients.
authors.affiliation: Department of Pharmacology, Kohwang Medical Research Institute, College of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Sheng-Yu
authors.initials: SY
authors.lastname: Jin
authors.forename: Hyun-Ho
authors.initials: HH
authors.lastname: Park
authors.forename: Guang-Zhe
authors.initials: GZ
authors.lastname: Li
authors.forename: Hee-Jae
authors.initials: HJ
authors.lastname: Lee
authors.forename: Mee-Suk
authors.initials: MS
authors.lastname: Hong
authors.forename: Seung-Jae
authors.initials: SJ
authors.lastname: Hong
authors.forename: Hun-Kuk
authors.initials: HK
authors.lastname: Park
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
authors.forename: Mu-Hyoung
authors.initials: MH
authors.lastname: Lee
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D007723:Korea; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D014820:Vitiligo / Q000209:etiology / Q000235:genetics*
chemical_list: D007703:Peptidyl-Dipeptidase A