Decreased adrenomedullin and total nitrite levels in breast milk of preeclamptic women.
OBJECTIVE
To observe the adrenomedullin (AM) and total nitrite levels in the milk of preeclamptic and normal pregnant women.


METHODS
Fifteen women with preeclampsia and 15 normal pregnant women were included in the study. Total nitrite was quantitated by Griess reaction, while AM was measured by HPLC.


RESULTS
The levels of AM and total nitrite in colostrum and 30th-day breast milk were decreased in preeclamptics. Total nitrite levels (micromol/l) were 56.09 +/- 11.18 vs. 82.20 +/- 12.01, P < 0.05, in colostrum of preeclamptics and controls, respectively. The level of total nitrite was 37.75 +/- 12.10 vs. 53.28 +/- 10.25, P < 0.05, in 30th-day milk of same patients. AM levels (pg/ml) were 11.18 +/- 1.11 vs. 16.59 +/- 1.24, P < 0.0001, in colostrum of preeclamptics and controls, respectively. In 30th-day milk of same patients, AM levels were 8.41 +/- 1.39 vs. 12.18 +/- 1.48, P < 0.005, respectively.


CONCLUSIONS
This report shows for the first time that human milk has decreased levels of AM and total nitrite in preeclampsia.
Cekmen
Mustafa Baki
MB
Department of Biochemistry, Medical Faculty, Kocaeli University, Izmit, Turkey. mustafacekmen@hotmail.com
Balat
Ayse
A
Balat
Ozcan
O
Aksoy
Fuat
F
Yurekli
Muhittin
M
Erbagci
Ayse Binnur
AB
Sahinoz
Saime
S
D053607:Adrenomedullin; D005260:Female; D006801:Humans; D008895:Milk, Human / Q000737:chemistry / Q000378:metabolism*; D009573:Nitrites / Q000737:chemistry / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D014421:Turkey
D009573:Nitrites; D010455:Peptides; D053607:Adrenomedullin