title: A low noise multichannel integrated circuit for recording neuronal signals using microelectrode arrays.
abstract: This paper reports on the development of a fully integrated 32-channel integrated circuit (IC) for recording neuronal signals in neurophysiological experiments using microelectrode arrays. The IC consists of 32 channels of low-noise preamplifiers and bandpass filters, and an output analog multiplexer. The continuous-time RC active filters have a typical passband of 20-2000 Hz; the low and the high cut-off frequencies can be separately controlled by external reference currents. This chip provides a satisfactory signal-to-noise ratio for neuronal signals with amplitudes greater than 50 microV. For the nominal passband setting, an equivalent input noise of 3 microV rms has been achieved. A single channel occupies 0.35 mm(2) of silicon area and dissipates 1.7 mW of power. The chip was fabricated in a 0.7 microm CMOS process.
authors.affiliation: Faculty of Physics and Nuclear Techniques, University of Mining and Metallurgy, al. Mickiewicza 30 30059 Krakow, Poland. w.dabrowski@ftj.agh.edu.pl
authors.forename: W
authors.initials: W
authors.lastname: Dabrowski
authors.forename: P
authors.initials: P
authors.lastname: Grybos
authors.forename: A M
authors.initials: AM
authors.lastname: Litke
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000669:Amplifiers, Electronic; D000703:Analog-Digital Conversion; D000818:Animals; D004867:Equipment Design; D019544:Equipment Failure Analysis; D000882:Haplorhini; D008839:Microelectrodes; D008904:Miniaturization; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000502:physiology; D012666:Semiconductors; D012680:Sensitivity and Specificity