[HG-viral infection in adults].
OBJECTIVE
To characterize the clinical and laboratory manifestations in patients with HG viral infection frequently concurrent with chronic HCV infection and the potentialities of their treatment.


METHODS
109 patients with suspected chronic hepatic disease were examined. The markers of HGV, HCV, HBV, and TTV infections were determined. The possible factors of infection, biochemical parameters, and the efficiency of antiviral therapy were assessed.


RESULTS
Hepatitis G virus RNK was detected in 32 cases, a combined variant of hepatitis G + C viruses RNA was found in 77 patients with chronic viral hepatitis (CVH). Among the presumed routes of contamination in the mixed variant of CVH, there were most common intravenous injection of narcotic drugs; in monoinfection (HGV), there were parenteral interventions in medical facilities and blood transfusion. Antiviral treatment of 13 patients with chronic HGV + HCV infection yielded a positive result in 5 patients after 3-month therapy.


CONCLUSIONS
In patients with CVH, HG virus infection was more frequently observed in combination with CVHC, less frequently as monoinfection. In HG virus monoinfection, biochemical studies revealed the enhanced activity of transaminases and hyperbilirubinemia that was absent in the mixed variant of HGV + HCV. The financial capacities of patients should be taken into account while choosing therapy.
Lisukova
T E
TE
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D018178:Flaviviridae Infections / Q000188:drug therapy / Q000209:etiology / Q000821:virology; D029407:GB virus C / Q000187:drug effects / Q000302:isolation & purification*; D006526:Hepatitis C / Q000188:drug therapy / Q000209:etiology / Q000821:virology; D006525:Hepatitis, Viral, Human / Q000188:drug therapy / Q000209:etiology / Q000821:virology; D006801:Humans; D008297:Male; D016896:Treatment Outcome
D000998:Antiviral Agents