Post-initiation inhibition of MeIQx hepatocarcinogenesis in rats by cysteine.
Rats were administered cysteine at a dose of 100 mg/kg b.w. 5 times per week after 2-amino-3, 8-dimethylimidazo [4,5-f] quinoxaline (MeIQx) treatment. Significant decrease in numbers and areas of glutathione S-transferase placental form (GST-P)-positive foci, putative preneoplastic lesions, and silver-stained nucleolar organizer regions were evident in the livers of rats treated with cysteine after MeIQx treatment. Morever, post-initiation stage cysteine treatment resulted in decreased hepatic insulin-like growth factor (IGF)-I mRNA expression. Thus post-initiation cysteine treatment may exert chemopreventive effect on MeIQx hepatocarcinogenesis.
Ogawa
Motome
M
The first Department of Pathology, Osaka City University Medical School, Japan.
Wanibuchi
Hideki
H
Nishkawa
Takayuki
T
Yano
Yoshihisa
Y
Otani
Shuzo
S
Totsuka
Yukari
Y
Wakabayashi
Keiji
K
Nakae
Dai
D
Fukushima
Shoji
S
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D003545:Cysteine / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000032:analysis; D016158:Genes, p53; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D009697:Nucleolus Organizer Region / Q000187:drug effects; D011230:Precancerous Conditions / Q000517:prevention & control*; D011810:Quinoxalines / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344
D011810:Quinoxalines; D007334:Insulin-Like Growth Factor I; C036990:2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D003849:Deoxyguanosine; D003545:Cysteine