Destruction with a box: substrate recognition by the anaphase-promoting complex.
Destruction boxes mark cyclin B and other proteins degraded in mitosis for ubiquitination by the anaphase-promoting complex (APC/C). In a paper in this issue of Molecular Cell, Yamano et al. show that destruction boxes directly bind to the APC/C in a cell cycle-regulated manner. Interestingly, this interaction does not require APC/C activators of the Cdc20 family, which were thought to be essential for recruiting substrates to the APC/C.
Zachariae
Wolfgang
W
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
D000818:Animals; D002453:Cell Cycle; D018797:Cell Cycle Proteins / Q000378:metabolism*; D019926:Cyclin B / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D008025:Ligases; D008938:Mitosis; D009154:Mutation; D025801:Ubiquitin / Q000378:metabolism*; D014981:Xenopus
D018797:Cell Cycle Proteins; D019926:Cyclin B; D025801:Ubiquitin; D008025:Ligases