Two new cytotoxic clerodane diterpenoids from Casearia membranacea.
In addition to casearlucin A (3), two new clerodane diterpenes, caseamembrols A (1) and B (2) have been isolated from the leaves and twigs of Casearia membranacea by bioassay-guided fractionation. The structures of the new compounds were established on the basis of extensive 1D- and 2D-NMR spectroscopic analysis. Compounds 1-3 exhibited significant cytotoxicity against human prostate (PC-3) cancer cells.
Shen
Ya-Ching
YC
Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan, Republic of China. ycshen@mail.nsysu.edu.tw
Wang
Li-Tung
LT
Wang
Chih-Hsin
CH
Khalil
Ashraf Taha
AT
Guh
Jih-Hwa
JH
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D037821:Casearia / Q000737:chemistry*; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D045785:Diterpenes, Clerodane; D000431:Ethanol; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology; D012997:Solvents; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045785:Diterpenes, Clerodane; D012997:Solvents; C488475:caseamembrol A; C488476:caseamembrol B; D000431:Ethanol