Granulomatous foreign body reaction against hyaluronic acid: report of a case after lip augmentation.
BACKGROUND
Hyaluronic acid (HA) (Restylane and Hylaform) is becoming more widely used for cosmetic procedures such as lip augmentation and treatment of facial skin lines, as other products, mainly bovine collagen, have proved allergenic in many patients.


OBJECTIVE
To report a case of a 48-year-old woman who developed discrete nodules in the lips after HA injection for lip augmentation. The histologic analysis revealed the presence of a granulomatous reaction surrounding a blue amorphous material with the tinctorial features of HA.


CONCLUSIONS
To our knowledge, this is the third case of granulomatous body reaction against this substance, which was allegedly inert in humans. Although rare, this reaction can have important aesthetic implications, and the patients should be informed about their risks.
Fernández-Aceñero
María Jesús
MJ
Department of Surgical Pathology, Hospital General de Móstoles, c/Hilarión Eslava 28 6o-A, 28015 Madrid, Spain. mgg10167@teleline.es
Zamora
Elena
E
Borbujo
Jesús
J
D003357:Cosmetic Techniques / Q000009:adverse effects*; D005260:Female; D015745:Granuloma, Foreign-Body / Q000209:etiology*; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects*; D008046:Lip; D008875:Middle Aged
D006820:Hyaluronic Acid