title: Copper-mediated synthesis of N-acyl vinylogous carbamic acids and derivatives: synthesis of the antibiotic CJ-15,801.
abstract: [reaction: see text] Copper(I)-mediated C-N bond formation has been employed to prepare both N-acyl vinylogous carbamic acids and ureas. The novel N-acyl vinylogous carbamic acid antibiotic, CJ-15,801, was synthesized using this methodology.
authors.affiliation: Department of Chemistry and Center for Chemical Methodology and Library Development, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
authors.forename: Chong
authors.initials: C
authors.lastname: Han
authors.forename: Ruichao
authors.initials: R
authors.lastname: Shen
authors.forename: Shun
authors.initials: S
authors.lastname: Su
authors.forename: John A
authors.initials: JA
authors.lastname: Porco
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D002219:Carbamates / Q000138:chemical synthesis*; D003300:Copper / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D014508:Urea / Q000138:chemical synthesis
chemical_list: D000900:Anti-Bacterial Agents; C449028:CJ-15,801; D002219:Carbamates; D010205:Pantothenic Acid; D003300:Copper; D014508:Urea