[The experimental study of PDLLA/rhBMP-2 compound screws for internal fixation of mandibular fracture].
OBJECTIVE
To study the effect of poly D,L-lactic acid (PDLLA) screws with PDLLA-rhBMP compound on bone regeneration in the screw holes and fracture ends of dog mandibles.


METHODS
A self-control study was carried out in 4 dogs. PDLLA/rhBMP-2 compound screws were implanted to fix the mental fractures and PDLLA screws were used as control. The samples from mandibles were collected at 4, 8, 12, 16 weeks after implantation and observed by radiography and histology.


RESULTS
All dogs showed a greater degree of bone regeneration around PDLLA/rhBMP-2 screws than PDLLA ones and all fractures were fixed and healed well.


CONCLUSIONS
The PDLLA-rhBMP screw has a better effect of inducing osteogenesis than PDLLA screw, and is able to exert a good fixation to fracture.
Luo
En
E
Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Zhou
Liwei
L
Wei
Shicheng
S
D000818:Animals; D001672:Biocompatible Materials / Q000008:administration & dosage; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage* / Q000096:biosynthesis / Q000235:genetics; D001863:Bone Screws; D004285:Dogs; D005593:Fracture Fixation, Internal / Q000379:methods*; D017102:Fracture Healing; D019344:Lactic Acid / Q000008:administration & dosage*; D008297:Male; D008337:Mandibular Fractures / Q000601:surgery*; D011091:Polyesters; D011108:Polymers / Q000008:administration & dosage*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000096:biosynthesis / Q000235:genetics; D016212:Transforming Growth Factor beta
D001672:Biocompatible Materials; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D011091:Polyesters; D011108:Polymers; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; D019344:Lactic Acid; C033616:poly(lactide)