title: Proteins controlling the nuclear uptake of NF-kappa B, Rel and dorsal.
abstract: The two DNA-binding subunits of the transcription factor NF-kappa B, the products of the rel oncogene family and the product of the developmental control gene dorsal of Drosophila are homologous within a 300 amino acid region. This sequence represents a novel DNA-binding and dimerization domain. The access of the NF-kappa B/Rel/dorsal (NRD) transcription factor family to the cell nucleus is regulated. There is now evidence that functionally and structurally related accessory proteins of NF-kappa B, Rel and dorsal control the nuclear entry as well as DNA-binding activity of the transcription factors. This review summarizes current knowledge about the nuclear-uptake regulatory proteins (NURPs) I kappa B-alpha, I kappa B-beta/pp40 and cactus.
authors.affiliation: Laboratorium für Molekulare Biologie der Ludwig-Maximilians-Universität, Genzentrum, Am Klopferspitz, D-8033 Martinsried, FRG.
authors.forename: M L
authors.initials: ML
authors.lastname: Schmitz
authors.forename: T
authors.initials: T
authors.lastname: Henkel
authors.forename: P A
authors.initials: PA
authors.lastname: Baeuerle