title: [Immunological monitoring of bone tissue resorption following endoprosthesis of large joints].
abstract: There was noted a reaction of the immune system to big-joint replacements, which developed both as a stereotype acute-phase response to the surgical intervention and a moderate immunosuppression, and as a response to the functioning of the implant (beginning from month 6 after surgery), when a mild phagocytes' activity and moderate changes in the acute-phase proteins were registered. Later, the monocyte-lymphocyte reaction of blood involving a higher production of osteoresorptive IL-1 and TNF were observed during the shaping resorption of osseous tissue. Complications can be prognosticated on the basis of the below: contents of leukocytes' main populations; activity of cytoplasm cation proteins; and concentration of the main classes of immunoglobulins and of IL-1.
authors.forename: O V
authors.initials: OV
authors.lastname: Berdiugina
authors.forename: V V
authors.initials: VV
authors.lastname: Bazarnyĭ
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis / Q000276:immunology; D000210:Acute-Phase Reaction / Q000097:blood / Q000276:immunology*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D001862:Bone Resorption / Q000097:blood / Q000209:etiology* / Q000276:immunology; D006621:Hip Joint / Q000601:surgery*; D006622:Hip Prosthesis; D006801:Humans; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology; D007378:Interleukins / Q000097:blood / Q000276:immunology; D007958:Leukocyte Count; D007962:Leukocytes / Q000166:cytology / Q000276:immunology; D010586:Phagocytes / Q000166:cytology / Q000276:immunology
chemical_list: D000209:Acute-Phase Proteins; D007136:Immunoglobulins; D007378:Interleukins