A novel class of tunable zinc reagents (RXZnCH2Y) for efficient cyclopropanation of olefins.
A class of zinc reagents (RXZnCH(2)Y) generated with an appropriate organozinc is very effective for the cyclopropanation of olefins. The reactivity and selectivity of these reagents can be regulated by tuning the electronic and steric nature of the RX group on Zn. A reasonable level of enantioselectivity was obtained for the cyclopropanation of unfunctionalized olefins when a chiral (iodomethyl)zinc species was used, providing a valuable approach for the asymmetric cyclopropanation of unfunctionalized olefins.
Lorenz
Jon C
JC
Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
Long
Jiang
J
Yang
Zhiqiang
Z
Xue
Song
S
Xie
Yinong
Y
Shi
Yian
Y