The bone marrow leaves its scar: new concepts in pulmonary fibrosis.
Excess collagen deposition occurs in pulmonary fibrosis. A new study suggests that collagen overproduction may originate from cells derived from bone marrow precursors rather than parenchymal lung fibroblasts.
Dunsmore
Sarah E
SE
Respiratory and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Shapiro
Steven D
SD
D000818:Animals; D001761:Bleomycin / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000473:pathology*; D019070:Cell Lineage; D003094:Collagen / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D005355:Fibrosis / Q000473:pathology*; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D008168:Lung / Q000473:pathology*; D008954:Models, Biological; D011658:Pulmonary Fibrosis / Q000473:pathology*; D013234:Stem Cells / Q000378:metabolism
D001761:Bleomycin; D003094:Collagen