Lens and retina regeneration: transdifferentiation, stem cells and clinical applications.
In this review we present a synthesis on the potential of vertebrate eye tissue regeneration, such as lens and retina. Particular emphasis is given to two different strategies used for regeneration, transdifferentiation and stem cells. Similarities and differences between these two strategies are outlined and it is proposed that both strategies might follow common pathways. Furthermore, we elaborate on specific clinical applications as the outcome of regeneration-based research.
Tsonis
Panagiotis A
PA
University of Dayton, Laboratory of Molecular Biology, Department of Biology, Dayton, OH 45469-2320, USA. panagiotis.tsonis@notes.udayton.edu
Del Rio-Tsonis
Katia
K
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D007908:Lens, Crystalline / Q000502:physiology*; D012038:Regeneration; D012160:Retina / Q000502:physiology*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*