Oxidative modification of erythrocyte membranes in the acute stage of severe craniocerebral trauma and its correction with clonidine.
Acute posttraumatic stage of severe craniocerebral trauma was characterized by considerable activation of lipid peroxidation and exhaustion of the antioxidant enzyme system. Oxidative modification of membranes was accompanied by structural and functional changes. The antihypoxic effect of clonidine was realized directly in the lipid phase of membranes. This preparation inhibited lipid peroxidation and activated antioxidant enzymes, which prevented the development of structural and functional changes in membranes.
Karmen
N B
NB
Institute of Experimental and Theoretical Biophysics, Russian Academy of Sciences, Pushchino. emaevsky@iteb.ru
D000208:Acute Disease; D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D002374:Catalase / Q000187:drug effects; D003000:Clonidine / Q000627:therapeutic use*; D015331:Cohort Studies; D006259:Craniocerebral Trauma / Q000378:metabolism* / Q000628:therapy*; D004359:Drug Therapy, Combination; D004789:Enzyme Activation / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D010084:Oxidation-Reduction; D012720:Severity of Illness Index; D013482:Superoxide Dismutase / Q000187:drug effects
D000975:Antioxidants; D002374:Catalase; D013482:Superoxide Dismutase; D003000:Clonidine