Hypereosinophilic syndrome: case presentation and update.
Persistent peripheral blood eosinophilia can be associated with a variety of diseases, ranging from parasitic infection to gastrointestinal disease to vasculitis to the hypereosinophilic syndrome (HES). Mucosal ulcerations are a variant presentation of the HES that appear to be markers for a mutation that characterizes a subgroup of patients with HES responsive to treatment with imatinib mesylate. We present a patient with peripheral blood eosinophilia and severe recurrent mucosal ulcers and discuss his presentation in the context of new information about the evaluation, disease progression, and treatment of HES.
Leiferman
Kristin M
KM
Department of Dermatology, University of Utah, Salt Lake City, Utah 84132-2409, USA.
Gleich
Gerald J
GJ
D000328:Adult; D001798:Blood Proteins; D003937:Diagnosis, Differential; D004699:Endocardium / Q000473:pathology; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000276:immunology*; D017809:Fatal Outcome; D006331:Heart Diseases / Q000175:diagnosis; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis* / Q000628:therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016898:Interferon-alpha / Q000627:therapeutic use; D007958:Leukocyte Count; D008297:Male; D019226:Oral Ulcer / Q000175:diagnosis* / Q000628:therapy; D010409:Penile Diseases / Q000175:diagnosis* / Q000628:therapy; D012260:Ribonucleases / Q000097:blood; D012883:Skin Ulcer / Q000175:diagnosis; D013156:Splenectomy
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D007166:Immunosuppressive Agents; D016898:Interferon-alpha; D012260:Ribonucleases