[Research advances in gene-enhanced tissue engineering].
Gene-enhanced engineering deals with the scientific and technologic endeavour to produce cultured cells or polymer matrices transduced with multiple gene vectors encoding cytokine cDNA by means of genetic engineering technique, to make transduced cells or gene activated matrices highly express according cytokine, and then to enhance certain abilities of the artificial tissue. Up to now, various genes encoding modulatory species of ribonucleic of proteins such as growth factors, receptors, and transcription factors have been used in the context of gene-enhanced tissue engineering and expressed within numerous tissues, including artificial blood vessels, bone, cartilage, skin and urinary system, etc. Many experiments in vitro or in vivo have begun to show good prospects and great potential application of the new approach. We believe great changes will take place in the research field of tissue engineering due to the induction the of genetic engineering, and the new approach will become a very promising and valuable tool for therapy.
Wu
Jiang
J
Institue of Biomedical Engineering, West China Medical Center of Sichuan University, Chengdu 610041.
Chen
Huaiqing
H
D001807:Blood Vessel Prosthesis; D018786:Bone Substitutes; D018014:Gene Transfer Techniques; D005818:Genetic Engineering / Q000379:methods; D023822:Tissue Engineering
D018786:Bone Substitutes