title: Human hantavirus infections, Sweden.
abstract: The prevalent human hantavirus disease in Sweden is nephropathia epidemica, which is caused by Puumala virus and shed by infected bank voles (Clethrionomys glareolus). To evaluate temporal and spatial patterns of this disease, we studied 2,468 reported cases from a highly disease-endemic region in northern Sweden. We found that, in particular, middle-aged men living in rural dwellings near coastal areas were overrepresented. The case-patients were most often infected in late autumn, when engaged in activities near or within manmade rodent refuges. Of 862 case-patients confident about the site of virus exposure, 50% were concentrated within 5% of the study area. The incidence of nephropathia epidemica was significantly correlated with bank vole numbers within monitored rodent populations in part of the region. Understanding this relationship may help forestall future human hantavirus outbreaks.
authors.affiliation: Swedish University of Agricultural Sciences, Umeå, Sweden. Gert.Olsson@szooek.slu.se
authors.forename: Gert E
authors.initials: GE
authors.lastname: Olsson
authors.forename: Fredrik
authors.initials: F
authors.lastname: Dalerum
authors.forename: Birger
authors.initials: B
authors.lastname: Hörnfeldt
authors.forename: Fredrik
authors.initials: F
authors.lastname: Elgh
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Palo
authors.forename: Per
authors.initials: P
authors.lastname: Juto
authors.forename: Clas
authors.initials: C
authors.lastname: Ahlm
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000818:Animals; D003411:Arvicolinae; D002648:Child; D002675:Child, Preschool; D021821:Communicable Diseases, Emerging / Q000453:epidemiology* / Q000635:transmission / Q000821:virology; D005260:Female; D006476:Orthohantavirus / Q000472:pathogenicity*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012424:Rural Population; D012621:Seasons; D017678:Sex Distribution; D011795:Surveys and Questionnaires; D013548:Sweden / Q000453:epidemiology