HIV type 1 diversity in northeastern Romania in 200-2001 based on phylogenic analysis of pol sequences from patient failing antiretroviral therapy.
Protease and the first half of reverse transcriptase from 71 Romanian patients failing highly active antiretroviral therapy (HAART) have been sequenced and phylogenetically analyzed. These analyses show that 70 patients were infected with subtype F1 and one with subtype C. The pattern of drug resistance mutations in subtype F1-infected patients failing HAART is similar to that described for subtype B strains. These results show that the diversity pattern of HIV type 1 infection in Romania has remained steady over a decade, with subtype F1 remaining the predominant viral form. The circulation of subtype F1 in Romania has the potential to be a source of this HIV-1 subtype in Europe..
Apetrei
Cristian
C
Virology Laboratory, Pathology Laboratory and Infectious diseases Clinic, School of Medicine, Gr. T. Popa University of Iasi, Romania. cristiana@tpc.tulane.edu
Descamps
Diane
D
Collin
Gilles
G
Robertson
David L
DL
Pandrea
Ivona
I
Groza
Petru
P
Prisecariu
Liviu
L
Teodorescu
Irina
I
Luca
Vasile
V
Brun-Vézinet
Françoise
F
D000293:Adolescent; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D024882:Drug Resistance, Viral / Q000235:genetics*; D015684:Gene Products, pol / Q000235:genetics*; D014644:Genetic Variation; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D015995:Prevalence; D012383:Romania; D019562:Viral Load; D054302:pol Gene Products, Human Immunodeficiency Virus
D015684:Gene Products, pol; C060467:HIV pol protein p65; D054302:pol Gene Products, Human Immunodeficiency Virus