A comparative study of the microcirculatory changes in the developing liver cirrhosis between the central and peripheral parts of the main lobe in mice.
A comparative study of the microcirculatory changes in the developing liver cirrhosis between the central and peripheral parts of the main lobe in mice. INTRODUCTION: To investigate whether a difference in microvascular vascular changes occurring in the peripheral and the central area of the main liver lobe exists and if, it can explain the liver atrophy observed predominantly in the peripheral part of the main liver lobe. MATERIALS AND METHODS: Liver cirrhosis was induced in mice and the microvascular changes asserted using an intravital microscopy system after 1, 2, 3 and 8 weeks of treatment. RESULTS: The mean blood velocity increased in the sinusoids; intrahepatic shunts appeared predominantly in the peripheral area and larger sized afferent terminal portal venules were rarefied in the peripheral area, with the central area being not affected. DISCUSSION: The difference between the peripheral and central area shows a decreased direct and indirect reduction of the blood flow to the periphery of the main lobe, through the reduced number of afferent terminal portal venules and the development of intrahepatic shunting.
Niggemann
Pascal
P
Department of Radiology, Center for Advanced Medical Technology, Nippon Medical School, 1-1-5 Sendagi, 113 8603, Tokyo, Japan
Murata
Satoru
S
Naito
Zenya
Z
Kumazaki
Tatsuo
T