Maternal treatment with propofol attenuates lipid peroxidation after transient intrauterine ischemia in the neonatal rat brain.
The purpose of this study was to investigate whether propofol has a neuroprotective effect on the fetal brain after intrauterine ischemia-reperfusion (I/R) injury in the rat fetus. Fetal brain ischemia was induced by clamping the utero-ovarian artery bilaterally for 30 min and reperfusion was achieved by removing the clamps for 2 h. A 40-mg/kg single dose of propofol was administered intraperitoneally 15 min before I/R injury. Lipid peroxidation in the brain tissue was determined as the concentration of thiobarbituric acid reactive substances (TBARS) for each fetal rat. Results showed that lipid peroxidation byproducts increased after I/R injury. Maternal treatment with propofol reduced TBARS compared to the I/R group. Propofol has been shown to have neuroprotective effects in intrauterine I/R-induced fetal brain damage in rats.
Solaroglu
Ihsan
I
Department of Neurosurgery, Ankara Numune Research and Education Hospital, Ankara, Turkey. isolaroglu@hotmail.com
Okutan
Ozerk
O
Solaroglu
Ayse
A
Kaptanoglu
Erkan
E
Beskonakli
Etem
E
Kilinc
Kamer
K
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D005260:Female; D005315:Fetal Diseases / Q000378:metabolism*; D015227:Lipid Peroxidation / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D011247:Pregnancy; D015742:Propofol / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
D018696:Neuroprotective Agents; D017392:Thiobarbituric Acid Reactive Substances; D015742:Propofol