title: [Correlation between basic expression level of NMDA receptor NR1 subunit protein in hippocampus and learning ability in rats].
abstract: To investigate the relationship between basic expression level of NMDA receptor NR1 subunit protein in hippocampus and learning ability of rats.
  
  
  
  Using a novel-object recognition model and Morris water maze,the novel-object recognition ability and spatial memory of SD rats were ranked, and grouped as the high (top 20 %) and the low (bottom 20%), respectively. NR1 subunit protein levels in hippocampus were measured by quantitative immunoblotting with NR1 subunit specific antibody.
  
  
  
  The level of NR1 subunit protein in hippocampus in the high novel-object recognition ability group was 60% (P<0.01), higher than that in the low one, and in the high spatial memory group it was 45.4 % (P<0.05), higher than that in the low one, respectively.
  
  
  
  The basic expression level of NR1 subunit protein in hippocampus is related to novel-object recognition ability and spatial memory of rats.
authors.affiliation: Department of Neurobiology, College of Medicine, Zhejiang University, Hangzhou 310006, China.
authors.forename: Shu-jun
authors.initials: SJ
authors.lastname: Xu
authors.forename: Hai-qing
authors.initials: HQ
authors.lastname: Shen
authors.forename: Zhong
authors.initials: Z
authors.lastname: Chen
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Zhu
authors.forename: Zhao-yang
authors.initials: ZY
authors.lastname: Zhu
authors.forename: Jian-hong
authors.initials: JH
authors.lastname: Luo
mesh_terms: D000818:Animals; D006624:Hippocampus / Q000737:chemistry* / Q000502:physiology; D015151:Immunoblotting; D007858:Learning; D008297:Male; D018782:Maze Learning; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D016194:Receptors, N-Methyl-D-Aspartate / Q000032:analysis* / Q000502:physiology
chemical_list: C409466:NR1 NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate