title: Bolaforms with fourteen galactose units: a proposed site-directed cohesion of cancer cells.
abstract: [structure: see text] The multistep synthesis of a calixarene joined to a second calixarene via a long spacer is described. Since each calixarene bears multiple galactose-based units (known to bind strongly to rat hepatoma cells), there existed the possibility of cross-linking the cancer cells into a network. The compounds did not serve this purpose, a fact potentially correctable by adjusting or rigidifying the spacer. Formation of a "cancer net" around a solid tumor remains a viable approach to retarding growth and/or inhibiting metastasis.
authors.affiliation: Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA. menger@emory.edu
authors.forename: Fredric M
authors.initials: FM
authors.lastname: Menger
authors.forename: Jianwei
authors.initials: J
authors.lastname: Bian
authors.forename: Elena
authors.initials: E
authors.lastname: Sizova
authors.forename: Deborah E
authors.initials: DE
authors.lastname: Martinson
authors.forename: Victor A
authors.initials: VA
authors.lastname: Seredyuk
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D047250:Calixarenes / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005690:Galactose / Q000737:chemistry; D015394:Molecular Structure; D051381:Rats
chemical_list: D000970:Antineoplastic Agents; D047250:Calixarenes; D005690:Galactose