Activation of dendritic cells: translating innate into adaptive immunity.
Innate recognition of infection in vertebrates can lead to the induction of adaptive immune responses through activation of dendritic cells (DCs). DCs are activated directly by conserved pathogen molecules and indirectly by inflammatory mediators produced by other cell types that recognise such molecules. In addition, it is likely that DCs are activated by poorly characterised cellular stress molecules and by disturbances in the internal milieu. The multiplicity of innate pathways for DC activation may have evolved to ensure that any signs of infection are detected early, before overwhelming pathogen replication. Understanding which of these signs are both necessary and sufficient to convert DCs into the immunostimulatory antigen-presenting cells that prime appropriate effector T cells may hold the key to improved strategies for vaccination and immunotherapy.
Reis e Sousa
Caetano
C
Cancer Research UK, London Research Institute, Lincoln's Inn Fields Laboratories, 44 Lincoln's Inn Fields, WC2A 3PX, London, UK. caetano@cancer.org.uk
D016207:Cytokines / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology*; D007113:Immunity, Innate; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D011971:Receptors, Immunologic / Q000502:physiology; D055607:Receptors, Natural Killer Cell; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors
D016207:Cytokines; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell; D051193:Toll-Like Receptors