title: Oral tetracyclines for ocular rosacea: an evidence-based review of the literature.
abstract: OBJECTIVE
  To review the basis for the use of oral tetracyclines in ocular rosacea.
  
  
  METHODS
  Review of the published literature.
  
  
  RESULTS
  Two prospective, masked, and placebo-controlled studies of oxytetracycline for ocular rosacea demonstrated a modest treatment benefit. Studies performed with tetracycline and doxycycline for ocular rosacea were not placebo controlled, and the optimal drug, dose, and schedule of administration were not evaluated.
  
  
  CONCLUSIONS
  Available evidence supports a moderate treatment benefit in ocular rosacea for oxytetracycline, a tetracycline derivative not currently available in the United States. The efficacies of doxycycline and tetracycline, including treatment effect, optimal dose, duration of therapy, and side effects when used for ocular rosacea have not been established.
authors.affiliation: Molecular Pathogenesis of Eyer Infection Research Center, Dean A. McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, 608 Stanton I. Young Boulevard, Oklahoma City, OK 73104, USA.
authors.forename: Donald U
authors.initials: DU
authors.lastname: Stone
authors.forename: James
authors.initials: J
authors.lastname: Chodosh
mesh_terms: D000284:Administration, Oral; D005128:Eye Diseases / Q000188:drug therapy*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012393:Rosacea / Q000188:drug therapy*; D013754:Tetracyclines / Q000008:administration & dosage*
chemical_list: D013754:Tetracyclines