title: The future for computational modelling and prediction systems in clinical immunology.
abstract: Advances in computational science, despite their enormous potential, have been surprisingly slow to impact on clinical practice. This paper examines the potential of bioinformatics to advance clinical immunology across a number of key examples including the use of computational immunology to improve renal transplantation outcomes, identify novel genes involved in immunological disorders, decipher the relationship between antigen presentation pathways and human disease, and predict allergenicity. These examples demonstrate the enormous potential for immunoinformatics to advance clinical and experimental immunology. The acceptance of immunoinformatic techniques by clinical and research immunologists will need robust standards of data quality, system integrity and properly validated immunoinformatic systems. Such validation, at a minimum, will require appropriately designed clinical studies conducted according to Good Clinical Practice standards. This strategy will enable immunoinformatics to achieve its full potential to advance and shape clinical immunology in the future.
authors.affiliation: Medical Informatics Centre, University of Canberra, Bruce ACT 2601, Australia.
authors.forename: Nikolai
authors.initials: N
authors.lastname: Petrovsky
authors.forename: Diego
authors.initials: D
authors.lastname: Silva
authors.forename: Vladimir
authors.initials: V
authors.lastname: Brusic
mesh_terms: D000485:Allergens; D000486:Allergy and Immunology / Q000706:statistics & numerical data*; D017951:Antigen Presentation; D019295:Computational Biology / Q000639:trends*; D003198:Computer Simulation; D006801:Humans; D007154:Immune System Diseases / Q000235:genetics; D014181:Transplantation Immunology
chemical_list: D000485:Allergens