Atovaquone/proguanil resistance in Africa: a case report.
The Atovaquone/proguanil combination has quickly been established as an effective chemoprophylaxis for travellers to areas with chloroquineresistant Plasmodium falciparum malaria. We describe the molecular cause of the first reported case of primary Atovaquone/proguanil resistance observed in our department in a Plasmodium falciparum infected traveller returning from West Africa, and link our findings to other reports of resistance.
David
Kim P
KP
Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark. kpd@dadlnet.dk
Alifrangis
Michael
M
Salanti
Ali
A
Vestergaard
Lasse S
LS
Rønn
Anita
A
Bygbjerg
I B
IB
D000328:Adult; D000349:Africa; D000818:Animals; D053626:Atovaquone; D001426:Bacterial Proteins / Q000235:genetics*; D003573:Cytochrome b Group / Q000235:genetics*; D003718:Denmark; D018432:Drug Resistance, Multiple; D004359:Drug Therapy, Combination; D005293:Ferritins / Q000235:genetics*; D006801:Humans; D016778:Malaria, Falciparum / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009285:Naphthoquinones / Q000008:administration & dosage* / Q000494:pharmacology; D010597:Pharmacogenetics; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics; D016133:Polymerase Chain Reaction; D002727:Proguanil / Q000008:administration & dosage* / Q000494:pharmacology; D018570:Risk Assessment; D014195:Travel; D017211:Treatment Failure
D001426:Bacterial Proteins; D003573:Cytochrome b Group; D009285:Naphthoquinones; D005293:Ferritins; C018032:bacterioferritin; D002727:Proguanil; D053626:Atovaquone