title: Predisposition to alcoholism, tryptophan oxygenase activity, and structure of intron 6 in the corresponding gene of C57BL/6J, CC57BR/Mv, and BALB/cJ mice.
abstract: Crossbred CC57BR/Mv mice inherited tryptophan oxygenase gene and predisposition to alcohol consumption from parent BALB/c and C57BL mice, respectively. In CC57BR/Mv mice no relationships were found between alcohol consumption, tryptophan oxygenase activity, and single nucleotide substitutions in intron 6 of the TDO2 gene associated with predisposition to alcoholism in humans.
authors.affiliation: Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk.
authors.forename: V I
authors.initials: VI
authors.lastname: Kaledin
authors.forename: N V
authors.initials: NV
authors.lastname: Klimova
authors.forename: G V
authors.initials: GV
authors.lastname: Vasil'ev
authors.forename: E A
authors.initials: EA
authors.lastname: Ivanova
authors.forename: E D
authors.initials: ED
authors.lastname: Vasil'eva
authors.forename: S I
authors.initials: SI
authors.lastname: Il'nitskaya
mesh_terms: D000437:Alcoholism / Q000235:genetics*; D000818:Animals; D001483:Base Sequence / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006824:Hybridization, Genetic; D007438:Introns; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D017384:Sequence Deletion; D014366:Tryptophan Oxygenase / Q000235:genetics* / Q000378:metabolism*
chemical_list: D014366:Tryptophan Oxygenase