title: [The different levels of prednisolone in perilymph after local and systemic treatment].
abstract: OBJECTIVE
  The present study was to analysis the pharmacokinetics of prednisolone-21-hydrogensuccinate in the perilymph after local and systemic application.
  
  
  METHODS
  On the local application, 5% prednisolone-21-hydrogensuccinate was directly applied into the round window niche under the microscopy. On the systemic application, the drug (60 mg/kg) was used intraperitoneal. Perilymphatic samples were obtained after variable periods of application. Levels of prednisolone-21-hydrogensuccinate in perilymph were measured by using HPLC.
  
  
  RESULTS
  The highest level of the drug was on (952.3 +/- 382.7) mg/L after 180 min. And remained on (18.72 +/- 16.97) mg/L after 960 min in the local application groups. In the systemic application group, the highest level of the drug was on(14.71 +/- 7.05) mg/L after 150 min.
  
  
  CONCLUSIONS
  The results demonstrate that high levels and long time remain of prednisolone-21-hydrogensuccinate in perilymph are achievable by a single dose local application into the round window niche.
authors.affiliation: Department of Otolaryngology, First Affiliated Hospital, Guangxi Medical University, Nanning 530021.
authors.forename: Jiping
authors.initials: J
authors.lastname: Su
authors.forename: G
authors.initials: G
authors.lastname: Bachmann
authors.forename: Anzhou
authors.initials: A
authors.lastname: Tang
authors.forename: C
authors.initials: C
authors.lastname: Zumegen
authors.forename: O
authors.initials: O
authors.lastname: Michel
authors.forename: C
authors.initials: C
authors.lastname: Wittekindt
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006168:Guinea Pigs; D008297:Male; D010498:Perilymph / Q000378:metabolism*; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*
chemical_list: D011239:Prednisolone; C021322:prednisolone hemisuccinate