[Using chemical methods to crosslink xenogeneic heart valves: the progress of bioprosthetic heart valves].
Glutaraldehyde clinically is the most commonly accepted crosslinking reagent for bioprosthetic valves preparation. Glutaraldehyde-treated tissue is stable against chemical and enzymatic degradation; however, its calcification and cytotoxicity are severe. Dye-mediated photooxidation is an alternative tissue preservation method that oxidizes the protein with visible light in the presence of a suitable photosensitizer. This article reviews chemical mechanism, research progress, clinical applications future development of these two methods.
Lin
Lin
L
Department of Chemistry, Tsinghua University, Beijing 100084, China.
Tang
Ying-wu
YW
Chang
Rui
R
Zhou
Jian-ye
JY
Cui
Jing-wei
JW
Hu
Sheng-shou
SS
Zhang
Fu-shi
FS
D000818:Animals; D001705:Bioprosthesis; D002114:Calcinosis; D003432:Cross-Linking Reagents; D005976:Glutaral; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D010777:Photochemistry
D003432:Cross-Linking Reagents; D005976:Glutaral