Telomeric position effect in yeast.
Telomeres are the physical ends of chromosomes. In yeast, when a gene is placed near a telomere, its transcription is repressed. Genes under the influence of this telomeric position effects switch between a repressed state and a transcriptionally active state, each of which is stable for many cell generations. Telomeric position effect may provide a model system for the study of heritable gene regulation in other, more complex organisms.
Sandell
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Fred Hutchinson Cancer Research Center, 1124 Columbia St, Seattle, WA 9810, USA.
Zakian
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