title: Is there a role for GPIs in yeast cell-wall assembly?
abstract: Glycosylphosphatidylinositol (GPI) membrane anchors are essential for the integration of yeast cell adhesion proteins into the cell wall, but mature cell-wall proteins are unlikely to be attached directly to the membrane. We thus propose that GPI-anchored glycoprotein forms are intermediates in a process that crosslinks the major components of the cell wall by transglycosylation. This mechanism may be critical for both the biosynthesis and overall architecture of the cell wall.
authors.affiliation: Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, VT 05405, USA.
authors.forename: H
authors.initials: H
authors.lastname: de Nobel
authors.forename: P N
authors.initials: PN
authors.lastname: Lipke