title: HLA-G and lymphoproliferative disorders.
abstract: The immunomodulatory properties of the HLA-G molecule explain its relevance in malignancies. Our investigations in lymphoproliferative disorders show (i) a frequent and variable distribution of alternatively spliced HLA-G mRNA isoforms, (ii) a rare cell surface expression in diffuse large cell lymphomas with HLA class I loss in half of cases, and (iii) an increased serum level of sHLA-G in half of cases. The potential role of the microenvironment and/or tumoral process in HLA-G expression is discussed in the light of these data. HLA-G rather through its soluble isoform might provide a new way of immune evasion for lymphoid proliferations.
authors.affiliation: Laboratoire Universitaire d'Hématologie et de la Biologie des Cellules Sanguines, UPRES EA 22-33, Faculté de Médecine, Université de Rennes 1, Rennes, France. laurence.amiot@chu-rennes.fr
authors.forename: Laurence
authors.initials: L
authors.lastname: Amiot
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Le Friec
authors.forename: Yasmine
authors.initials: Y
authors.lastname: Sebti
authors.forename: Bernard
authors.initials: B
authors.lastname: Drénou
authors.forename: Céline
authors.initials: C
authors.lastname: Pangault
authors.forename: Valérie
authors.initials: V
authors.lastname: Guilloux
authors.forename: Xavier
authors.initials: X
authors.lastname: Leleu
authors.forename: Marc
authors.initials: M
authors.lastname: Bernard
authors.forename: Thierry
authors.initials: T
authors.lastname: Facon
authors.forename: Renée
authors.initials: R
authors.lastname: Fauchet
mesh_terms: D002455:Cell Division; D004797:Enzyme-Linked Immunosorbent Assay; D005091:Exons; D005434:Flow Cytometry; D006680:HLA Antigens / Q000097:blood / Q000276:immunology* / Q000502:physiology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000097:blood / Q000276:immunology* / Q000502:physiology*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000276:immunology* / Q000378:metabolism; D009101:Multiple Myeloma / Q000276:immunology; D020033:Protein Isoforms; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D020033:Protein Isoforms; D012333:RNA, Messenger