A new perspective on nerve-sparing radical hysterectomy: nerve topography and over-preservation of the cardinal ligament.
BACKGROUND
Nerve-sparing radical hysterectomy was established by Japanese gynecologists. They identified two parts of the cardinal ligament, namely the vascular part and the neural part, and postulated that the neural part contained the pelvic splanchnic nerves. However, our fresh cadaver studies demonstrated that these nerves ran dorsomedially in contrast to the classical concept. The aim of this study is to further validate this finding in clinical cases.


METHODS
We examined the intraoperative biopsy specimens collected from the neural part of the cardinal ligament in four patients with cervical carcinoma who underwent nerve-sparing radical hysterectomy with dissection of the neural part.


RESULTS
Careful dissections demonstrated that the pelvic splanchnic nerves arise from the dorsomedial side of the neural part at the bottom of the pararectal space. The neural part was composed of a connective tissue with focal positive staining by S-100 protein.


CONCLUSIONS
We propose that complete dissection of the cardinal ligament should be performed during nerve-sparing hysterectomy to increase its radicality.
Kato
Tomoyasu
T
Department of Gynecology, Cancer Institute Hospital, Tokyo, Japan. tomoyasu.kato@jfcr.or.jp
Murakami
Gen
G
Yabuki
Yoshihiko
Y
D001956:Broad Ligament / Q000294:innervation* / Q000601:surgery; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods; D006801:Humans; D007044:Hysterectomy / Q000379:methods*; D017933:Peripheral Nervous System / Q000033:anatomy & histology*; D013153:Splanchnic Nerves / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000601:surgery*