Corneal epithelial barrier function in diabetic patients.
OBJECTIVE
To evaluate the corneal epithelial barrier function in diabetic patients.


METHODS
In 29 eyes of 29 diabetic patients and 55 eyes of 55 nondiabetic controls, corneal epithelial permeability to fluorescein was measured using an anterior fluorophotometer. The average fluorescein concentration in the central cornea was compared between diabetic patients and controls. Multiple regression analysis was used to assess the factors that affect corneal epithelial barrier function in diabetic patients.


RESULTS
The average fluorescein concentrations in diabetic patients and nondiabetic controls were 44.1 +/- 25.3 ng/mL and 29.9 +/- 19.8 ng/mL (mean +/- SD), respectively (P = 0.0057, unpaired t test). An explanatory variable relevant to the impaired corneal epithelial barrier function was the serum hemoglobin A1c (HbA1c) concentration (standardized partial regression coefficient = 0.466, P = 0.0163).


CONCLUSIONS
The corneal epithelial barrier function is impaired in diabetic patients. Diabetic patients with higher serum HbA1c levels are more predisposed to impaired barrier function in the corneal epithelium.
Gekka
Mamomu
M
Meiwakai Medical Foundation, Miyata Eye Hospital, Miyakonojo, Miyazaki, Japan.
Miyata
Kazunori
K
Nagai
Yuji
Y
Nemoto
Shingo
S
Sameshima
Tomokazu
T
Tanabe
Tatsuro
T
Maruoka
Shinji
S
Nakahara
Masaaki
M
Kato
Satoshi
S
Amano
Shiro
S
D000368:Aged; D003287:Contrast Media / Q000493:pharmacokinetics; D003920:Diabetes Mellitus / Q000097:blood / Q000378:metabolism*; D019573:Epithelium, Corneal / Q000378:metabolism*; D019793:Fluorescein / Q000493:pharmacokinetics; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D010539:Permeability
D003287:Contrast Media; D019793:Fluorescein; D006442:Glycated Hemoglobin