Anti-alpha-enolase antibodies in pituitary disease.
A previous study reported a high prevalence of autoantibodies to alpha-enolase in lymphocytic hypophysitis and these antibodies efficiently distinguished lymphocytic hypophysitis from pituitary tumors. To confirm this, we examined autoantibodies to alpha-enolase in patients with lymphocytic hypophysitis (n = 17), pituitary non-functioning adenoma (n = 13), other pituitary diseases (n = 17) and other autoimmune diseases (n = 30), and compared to healthy controls (n = 46). Autoantibodies were found in 41.2%, 46.2%, 23.5%, 20.0% and 4.3%, respectively. Our findings indicate that detection of anti-alpha-enolase antibodies is not suitable for specific diagnosis of lymphocytic hypophysitis.
Tanaka
Susumu
S
Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita-shi, Osaka, Japan.
Tatsumi
Ke-Ita
KI
Takano
Toru
T
Murakami
Yoshio
Y
Takao
Toshihiro
T
Yamakita
Noriyoshi
N
Tahara
Shigeyuki
S
Teramoto
Akira
A
Hashimoto
Kozo
K
Kato
Yuzuru
Y
Amino
Nobuyuki
N
D000236:Adenoma / Q000175:diagnosis / Q000276:immunology; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology*; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000276:immunology*; D010900:Pituitary Diseases / Q000175:diagnosis / Q000201:enzymology* / Q000276:immunology*; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000276:immunology; D025521:Tumor Suppressor Proteins / Q000276:immunology*
D001323:Autoantibodies; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D025521:Tumor Suppressor Proteins; C095157:ENO1 protein, human; D010751:Phosphopyruvate Hydratase