Antidiabetic activity of Bauhinia forficata extracts in alloxan-diabetic rats.
The antidiabetic activity of aqueous, ethanolic and hexanic extracts of Bauhinia forficata was investigated in a model of alloxan-induced diabetes in rats. The biochemical parameters studied were: plasma glucose, serum triglycerides, cholesterol, high density lipoprotein (HDL), and low density lipoprotein (LDL). Extracts were administered daily for 7 d at doses of 200 and 400 mg/kg, p.o., 48 h after alloxan injection (60 mg/kg, i.v.). The alloxan-diabetic rats showed significant reductions in plasma glucose, triglycerides, total cholesterol and HDL-cholesterol after treatment with the extracts and glibenclamide (used as standard) as compared to the diabetic controls. Levels of LDL were not altered. In conclusion, our results showed that the plant extracts when administered by gavage may reduce glucose, triglycerides, total cholesterol and HDL-cholesterol levels. These results suggest the validity of the clinical use of B. forficata in the treatment of diabetes mellitus type II.
Lino
Cleide de Sousa
Cde S
Department of Physiology and Pharmacology, Federal University of Ceará, Coronel Nunes de Melo 1127, 60430-270 Fortaleza, Ceará, Brazil. cleidelino@yahoo.com.br
Diógenes
João Paulo Luz
JP
Pereira
Bruno Azevedo
BA
Faria
Rozilaine Aparecida Pelegrine Gomes
RA
Andrade Neto
Manoel
M
Alves
Renata Sousa
RS
de Queiroz
Maria Goreti Rodrigues
MG
de Sousa
Francisca Cléa Florenço
FC
Viana
Glauce Socorro Barros
GS
D000818:Animals; D036481:Bauhinia / Q000737:chemistry*; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D000431:Ethanol; D005905:Glyburide / Q000494:pharmacology; D006586:Hexanes; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents; D014280:Triglycerides / Q000097:blood; D014867:Water
D001786:Blood Glucose; D008076:Cholesterol, HDL; D006586:Hexanes; D007004:Hypoglycemic Agents; D008055:Lipids; D010936:Plant Extracts; D012997:Solvents; D014280:Triglycerides; D014867:Water; D000431:Ethanol; D002784:Cholesterol; D005905:Glyburide