title: Blood pressure decrease during the acute phase of ischemic stroke is associated with brain injury and poor stroke outcome.
abstract: OBJECTIVE
  Studies on the relation between blood pressure (BP) and stroke outcome have shown contradictory results. We explored the association of systolic (SBP) and diastolic (DBP) BP during acute stroke with early neurological deterioration, infarct volume, neurological outcome, and mortality at 3 months.
  
  
  METHODS
  We included 304 patients with acute ischemic stroke. SBP and DBP on admission and on the first day were the average values of all readings obtained in the emergency department and during a 24-hour period after patient allocation in the stroke unit.
  
  
  RESULTS
  A U-shaped effect was observed: for every 10 mm Hg <or=180 mm Hg of SBP, the risk of early neurological deterioration, poor outcome, and mortality increased by 6%, 25%, and 7%, respectively, whereas for every 10 mm Hg >180 mm Hg, the risk of early neurological deterioration increased by 40% and the risk of poor outcome increased by 23%, with no effect on mortality. Mean infarct volume increased 7.3 and 5.5 cm(3) for every 10 mm Hg <or=180 and >180 mm Hg. A similar pattern was found in patients with DBP <or=100 or >100 mm Hg. These effects disappeared after adjustment for the use of antihypertensive drugs and BP drop >20 mm Hg within the first day, with the latter being the more important prognostic factor of poor outcome.
  
  
  CONCLUSIONS
  High and low SBP and DBP, as well as a relevant drop in BP, are associated with poor prognosis in patients with ischemic stroke.
authors.affiliation: Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela, Spain. mecasti@usc.es
authors.forename: José
authors.initials: J
authors.lastname: Castillo
authors.forename: Rogelio
authors.initials: R
authors.lastname: Leira
authors.forename: María M
authors.initials: MM
authors.lastname: García
authors.forename: Joaquín
authors.initials: J
authors.lastname: Serena
authors.forename: Miguel
authors.initials: M
authors.lastname: Blanco
authors.forename: Antoni
authors.initials: A
authors.lastname: Dávalos
mesh_terms: D000208:Acute Disease; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002545:Brain Ischemia / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D003971:Diastole; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D007022:Hypotension / Q000150:complications / Q000503:physiopathology*; D008297:Male; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index; D020521:Stroke / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D015996:Survival Rate; D013599:Systole; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents