Progressive multifocal leukoencephalopathy in a patient with X-linked agammaglobulinemia.
To our knowledge, this is the first case report describing progressive multifocal leukoencephalopathy (PML) associated with X-linked agammaglobulinemia. The JC virus was confirmed at autopsy and PML was diagnosed. Humoral immunodeficiency with normal cellular immunity could be infected with JCV.
Teramoto
Takahide
T
Department of Pediatrics, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan. t-tera@cc.gifu-u.ac.jp
Kaneko
Hideo
H
Funato
Michinori
M
Sawa
Hirofumi
H
Nagashima
Kazuo
K
Hirose
Yoshinobu
Y
Kondo
Naomi
N
D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications* / Q000175:diagnosis / Q000235:genetics; D001707:Biopsy, Needle; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D007577:JC Virus / Q000302:isolation & purification*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D012131:Respiratory Insufficiency; D018570:Risk Assessment; D012720:Severity of Illness Index