[Features of interferon and cytokine production in genital herpes].
The impaired production of INFs and of other cytokines at different stages of their synthesis in patients with genital herpes before and after treatment were shown to reflect the specificity of the immune response in the mentioned pathology. An activation of the cellular and humoral immunity according to the Th1 and Th2 types was observed in patients with genital herpes. The stimulated activity of Th1, B-lymphocytes and of natural killers (NK) as well as suppression of Th2 occurred in the initial treatment stage by acyclovir (10 days), which brought about a positive clinical effect in a majority of cases. A correlation between the IFN status and cytokine profile, on the one hand, and an effect of therapy in genital herpes, on the other hand, was demonstrated. Finally, the monitoring of the IFN and cytokine status in each patient is needed for choosing a treatment scheme and for prognosticating a therapy efficiency.
Mezentseva
M V
MV
Shcherbenko
V E
VE
Narovlianskiĭ
A N
AN
Farfarovskiĭ
M S
MS
Pavlov
V I
VI
Pavlova
S V
SV
Ershov
F I
FI
D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D016207:Cytokines / Q000096:biosynthesis*; D006558:Herpes Genitalis / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007372:Interferons / Q000096:biosynthesis*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
D000998:Antiviral Agents; D016207:Cytokines; D007372:Interferons; D000212:Acyclovir