title: Necrotizing soft-tissue infections.
abstract: It has been more than 130 years since NSTIs were first described. Despite the development of various classification systems and progress in surgical management, these infections continue to have high mortality and pose enormous diagnostic and therapeutic challenges. For optimal outcome, treatment involves rapid institution of appropriate antibiotic coverage and early wide surgical debridement. Recovery requires aggressive resuscitation, postoperative nutritional support and wound care that is similar to the care of burn patients in many respects. The entire therapeutic process requires a well-prepared and coordinated team of health care professionals including EPs, general, orthopedic, and other specialist surgeons, infectious disease consultants, specially trained nursing staff, and physical therapists.
authors.affiliation: Trauma Service A, Division of Trauma and Surgical Critical Care, University of Southern California, Keck School of Medicine, LAC - USC Medical Center, 1200 North State Street, Room 10-750, Los Angeles, CA 90033-4525, USA.
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Kuncir
authors.forename: Areti
authors.initials: A
authors.lastname: Tillou
authors.forename: Charles R
authors.initials: CR
authors.lastname: St Hill
authors.forename: Patrizio
authors.initials: P
authors.lastname: Petrone
authors.forename: Brian
authors.initials: B
authors.lastname: Kimbrell
authors.forename: Juan A
authors.initials: JA
authors.lastname: Asensio
mesh_terms: D006801:Humans; D009336:Necrosis; D011379:Prognosis; D012307:Risk Factors; D018461:Soft Tissue Infections / Q000145:classification / Q000175:diagnosis* / Q000382:microbiology / Q000628:therapy*