Retinal detachment from inadvertent intraocular injection of botulinum toxin A.
OBJECTIVE
To report a case of inadvertent intraocular injection of botulinum toxin A (Botox, BTA) resulting in a retinal tear and bullous retinal detachment. The retinal detachment resolved spontaneously, and the tear was treated with laser demarcation with good visual outcome.


METHODS
Interventional case report.


METHODS
A 36-year-old woman underwent Botox injections for paralytic esotropia and developed ocular perforation. Dilated fundus examination showed a slit-like retinal tear infranasally with a bullous retinal detachment nasally.


RESULTS
The retinal detachment spontaneously resolved, and the patient was treated with laser demarcation on the following day. After 2 more days, her vision returned to baseline.


CONCLUSIONS
Botox did not appear toxic to human intraocular tissues. Close observation may be indicated in the event of an inadvertent intraocular Botox injection.
Liu
Mimi
M
Retina Service, Wills Eye Hospital, Philadelphia, Pennsylvania 19107, USA.
Lee
Henry C
HC
Hertle
Richard W
RW
Ho
Allen C
AC
D000328:Adult; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D004948:Esotropia / Q000188:drug therapy; D015807:Eye Injuries, Penetrating / Q000209:etiology / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D007267:Injections / Q000009:adverse effects*; D017075:Laser Coagulation; D016602:Needlestick Injuries / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D009801:Oculomotor Muscles / Q000187:drug effects; D012160:Retina / Q000187:drug effects / Q000293:injuries* / Q000503:physiopathology; D012163:Retinal Detachment / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D012167:Retinal Perforations / Q000209:etiology; D012590:Sclera / Q000293:injuries; D014792:Visual Acuity
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A