Age-related changes in expression of CXCR4 and CCR5 on peripheral blood leukocytes from uninfected infants born to human immunodeficiency virus type 1-infected mothers.
Cross-sectional analysis of human immunodeficiency virus-exposed, uninfected infants revealed high proportions of CXCR4-expressing cells in their cord blood, which declined at 4.5 months and increased between 9 and 15 months to levels approaching those of uninfected adults. Proportions of CCR5-expressing cells, however, were very low in cord blood and subsequently increased with age.
Shalekoff
Sharon
S
AIDS Virus Research Unit, National Institute for Communicable Diseases, and Department of Virology, Johannesburg, South Africa.
Gray
Glenda E
GE
Tiemessen
Caroline T
CT
D000328:Adult; D000367:Age Factors; D003430:Cross-Sectional Studies; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000635:transmission; D015497:HIV-1; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D007962:Leukocytes / Q000276:immunology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology*; D019713:Receptors, CCR5 / Q000097:blood*; D019718:Receptors, CXCR4 / Q000097:blood*
D019713:Receptors, CCR5; D019718:Receptors, CXCR4