Free radical scavenging activity of chitooligosaccharides by electron spin resonance spectrometry.
The radical scavenging effects of chitooligosaccharides (COSs) on hydroxyl radical, superoxide radical, alkyl radical, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical were investigated using a spin-trapping electron spin resonance (ESR) method and compared with the ESR signal intensity. COSs exhibited strong scavenging activity on hydroxyl radical and superoxide radical and weak scavenging activity on alkyl radical and DPPH radical. The radical scavenging activity of COSs increased with increment of concentration, and it was also dependent on molecular weight. These results suggest that the scavenging activity of COSs is dependent on their molecular weights and tested radicals.
Park
Pyo-Jam
PJ
Department of Chemistry, Pukyong National University, Busan 608-737, Korea.
Je
Jae-Young
JY
Kim
Se-Kwon
SK
D001713:Biphenyl Compounds; D048271:Chitosan / Q000737:chemistry* / Q000494:pharmacology; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000737:chemistry*; D017665:Hydroxyl Radical / Q000737:chemistry; D008970:Molecular Weight; D009844:Oligosaccharides / Q000737:chemistry* / Q000494:pharmacology; D010851:Picrates / Q000737:chemistry; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000737:chemistry
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D009844:Oligosaccharides; D010851:Picrates; D013481:Superoxides; D017665:Hydroxyl Radical; D048271:Chitosan; C004931:1,1-diphenyl-2-picrylhydrazyl