title: Classical juvenile pityriasis rubra pilaris in a patient with Down syndrome.
abstract: We report a case of classical juvenile pityriasis rubra pilaris (CJPRP) in a 15-year-old boy with Down syndrome. The rash was extensive, severe, accompanied by intense itching and responded to low-dose etretinate. Xerosis and cheilitis were also present, suggesting that keratinization defects associated with Down syndrome may be involved in the pathogenesis of CJPRP. PRP is a rare dermatological disorder and to the best of our knowledge, this is the first reported case of CJPRP in a patient with Down syndrome.
authors.affiliation: Department of Dermatology, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan. ken0913@m2.kufm.kagoshima-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Terasaki
authors.forename: T
authors.initials: T
authors.lastname: Kanekura
authors.forename: H
authors.initials: H
authors.lastname: Saruwatari
authors.forename: T
authors.initials: T
authors.lastname: Kanzaki
mesh_terms: D000293:Adolescent; D004314:Down Syndrome / Q000150:complications*; D006801:Humans; D008297:Male; D010916:Pityriasis Rubra Pilaris / Q000150:complications* / Q000473:pathology