title: A disturbance of the gastric myoelectric activity in post-operative patients with biliary atresia.
abstract: BACKGROUND
  Abnormalities in gastrointestinal motility have been reported in adult patients with advanced liver disease. However, there have so far been no reports on the gastric myoelectric activity in post-operative patients with biliary atresia (BA).
  
  
  OBJECTIVE
  The purpose of this study was to evaluate the gastric myoelectric activity in post-operative patients with BA in relation to liver fibrosis.
  
  
  METHODS
  Twenty-one post-operative patients with BA, consisting of 6 boys and 15 girls with a mean age of 8.0 years and 6 healthy children (control group) were included in the study. The gastric myoelectric activity was measured by electrogastrography (EGG). The patients with BA were divided into two groups according to the serum hyaluronic acid (HA) level as a marker of liver fibrosis: the fibrotic group (FG, n=11), HA>50 ng/ml and the non-fibrotic group (NF, n=10), HA <==50 ng/ml. All recorded data were spectrally analyzed and any parameters related to changes in the dominant peak frequency (DPF) and its power were investigated. Furthermore, the gastrointestinal symptom scores (GSS) were calculated in patients with dyspeptic symptoms according to the degree of advanced liver fibrosis.
  
  
  RESULTS
  The results showed that 1) the postprandial DPF in the FG tended to be higher than that in the NFG ( p=0.051), 2) the postprandial variability index of the DPF in the FG and NFG were significantly higher than those in the controls ( p<0.05), and 3) the preprandial percentage of normal waves (PNW) in the FG tended to be lower than that in the controls ( p=0.089). The postprandial PNWs in the FG and NFG were significantly lower than those in the controls ( p<0.05). Especially, the postprandial PNW in the FG was significantly lower than that in the NFG ( p<0.05). 4) The power ratio in the FG and NFG were significantly lower than those in the controls ( p<0.05), and 5) the GSSs in the FG were significantly higher than those in the NFG ( p<0.05).
  
  
  CONCLUSIONS
  The gastric myoelectric activity appeared to be disturbed in BA patients associated with portal hypertension and neurohormonal changes due to liver fibrosis.
authors.affiliation: Department of Pediatric Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Niigata City, Japan. masa-o@xd5.so-net.ne.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ohtaki
authors.forename: Minoru
authors.initials: M
authors.lastname: Yagi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kubota
authors.forename: Shinji
authors.initials: S
authors.lastname: Homma
mesh_terms: D000293:Adolescent; D000328:Adult; D001656:Biliary Atresia / Q000150:complications / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D013505:Digestive System Surgical Procedures / Q000009:adverse effects* / Q000379:methods; D004415:Dyspepsia / Q000097:blood / Q000150:complications / Q000503:physiopathology; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D006975:Hypertension, Portal / Q000150:complications* / Q000503:physiopathology; D007223:Infant; D008103:Liver Cirrhosis / Q000209:etiology / Q000503:physiopathology; D008297:Male; D016065:Myoelectric Complex, Migrating / Q000502:physiology*
chemical_list: D006820:Hyaluronic Acid