Modification of delayed radiation-induced reactions of duodenal vessels and mast cells in old rats.
Pronounced ultrastructural changes in vessels and mast cells were observed in duodenal lamina propria of Wistar rats 1 year after single whole-body gamma-irradiation in a dose of 7.5 Gy. Inhibition of adrenocortical function with methopyrone reduced structural damage and improved animal survival.
Popuchiev
V V
VV
Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk; Institute of Industrial Organic Chemistry, Pschina, Poland. popoutch@mrrc.obninsk.ru
Mikhina
L N
LN
Yakovleva
N D
ND
Konoplyannikov
A G
AG
Yuzhakov
V V
VV
Odintsova
E A
EA
Brodskii
R A
RA
Sevan'kaeva
L E
LE
Kita
K
K
Kita
I
I
D000367:Age Factors; D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D004386:Duodenum / Q000098:blood supply* / Q000187:drug effects / Q000528:radiation effects* / Q000648:ultrastructure; D005500:Follow-Up Studies; D005720:Gamma Rays; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000528:radiation effects* / Q000648:ultrastructure; D008797:Metyrapone / Q000494:pharmacology; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014916:Whole-Body Irradiation
D002395:Catecholamines; D011837:Radiation-Protective Agents; D008797:Metyrapone