Caloric restriction and insulin-like growth factors in aging and cancer.
This review examines the influence of a reduction in caloric intake on cancer and longevity. Data indicating that rodents subjected to caloric restriction display lower tumor incidence, reduced susceptibility to carcinogens and extended lifespan is analyzed. The potential role of the growth hormone/insulin-like growth factor type 1 (IGF-I) axis in this effect is discussed as is the evidence that a reduction in growth hormone and/or IGF-I leads to a reduction in spontaneous tumors and susceptibility to carcinogens.
Sell
Ch
Ch
Lankenau Institute for Medical Research, Wynnewood, PA 19096, USA. sellc@mlhs.org
D000375:Aging / Q000502:physiology*; D000818:Animals; D004038:Diet, Reducing; D002149:Energy Intake; D006801:Humans; D015994:Incidence; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D007335:Insulin-Like Growth Factor II / Q000502:physiology*; D023421:Models, Animal; D009369:Neoplasms / Q000453:epidemiology / Q000503:physiopathology* / Q000517:prevention & control
D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II