Therapeutic effect of aromatase inhibitor in two azoospermic dogs with high plasma estradiol-17beta levels.
Two azoospermic dogs with high plasma estradiol-17 beta (E(2)) levels were subcutaneously injected with an aromatase inhibitor (AI), 4-androstene-4-ol-3,17-dione, 2 mg every other day for 4 weeks. Before the AI treatment the plasma E(2) levels of the two dogs (21 and 22 pg/ml, respectively) were higher than those of 2 normal dogs (8.1 and 12.3 pg/ml), and they fell to 11-17 pg/ml between 1 and 4 weeks after the start of AI treatment. The plasma testosterone levels after the start of AI treatment had increased to 2.1-3.1 ng/ml. A small number of sperm were detected in the semen of the two dogs between 3 and 6 weeks after the start of AI treatment. These results indicate that the testicular function of infertile dogs with high plasma E(2) levels can be temporarily improved by AI therapy.
Kawakami
Eiichi
E
Department of Reproduction, Nippon Veterinary and Animal Science University, Tokyo, Japan.
Taguchi
Naomi
N
Hirano
Taichi
T
Hori
Tatsuya
T
Tsutsui
Toshihiko
T
D000818:Animals; D047072:Aromatase Inhibitors; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy*; D004285:Dogs; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood*; D007273:Injections, Intramuscular; D008297:Male; D009845:Oligospermia / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000002:abnormalities; D013739:Testosterone / Q000097:blood
D047072:Aromatase Inhibitors; D006063:Chorionic Gonadotropin; D004791:Enzyme Inhibitors; D013739:Testosterone; D004958:Estradiol