Alpha-synuclein haplotypes implicated in risk of Parkinson's disease.
The authors examined four- and six-loci haplotype constructs (from five single nucleotide polymorphisms and three microsatellite regions) of the alpha-synuclein gene in patients with Parkinson's disease (PD) and controls in an ethnic Chinese population. Logistic regression analysis demonstrated an association of NACP-Rep1 (p = 0.002) and L478 (p < 0.0001) with risk of PD after correction for the effects of age, sex, and the other polymorphic loci. Specific four-loci and six-loci haplotypes were significantly associated with an increased or decreased risk of PD.
Tan
E K
EK
Department of Neurology, Singapore General Hospital, Singapore. gnrtek@sgh.com.sg
Chai
A
A
Teo
Y Y
YY
Zhao
Y
Y
Tan
C
C
Shen
H
H
Chandran
V R
VR
Teoh
M L
ML
Yih
Y
Y
Pavanni
R
R
Wong
M C
MC
Puvan
K
K
Lo
Y L
YL
Yap
E
E
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015994:Incidence; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009010:Monte Carlo Method; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016017:Odds Ratio; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D018570:Risk Assessment; D012846:Singapore / Q000453:epidemiology; D051843:Synucleins; D051844:alpha-Synuclein
D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein