title: Colchicine-induced rhabdomyolysis in a patient with chronic heart failure.
abstract: Gout is a common co-morbidity in patients with chronic heart failure and its treatment is complex. We report the case of a 58-year-old man with chronic severe heart failure who developed rhabdomyolisis after short-term intake of colchicine. Although colchicine is a highly effective therapy for acute gouty arthritis, the dosage should be carefully titrated in patients with chronic heart failure, especially if renal or liver disease are also present.
authors.affiliation: Department of Cardiology, University Hospital Antwerp, Edegem, Belgium. karen.debie@uza.be
authors.forename: Karen
authors.initials: K
authors.lastname: Debie
authors.forename: Viviane
authors.initials: V
authors.lastname: Conraads
authors.forename: Christiaan
authors.initials: C
authors.lastname: Vrints
mesh_terms: D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D003078:Colchicine / Q000009:adverse effects*; D003402:Creatine Kinase / Q000097:blood; D003404:Creatinine / Q000097:blood; D006073:Gout / Q000188:drug therapy; D006074:Gout Suppressants / Q000009:adverse effects*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D012206:Rhabdomyolysis / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D015415:Biomarkers; D006074:Gout Suppressants; D003404:Creatinine; D003402:Creatine Kinase; D003078:Colchicine