title: Prevalence of human immunodeficiency virus drug resistance mutations and subtypes in drug-naive, infected individuals in the army health service of Rio de Janeiro, Brazil.
abstract: The prevalence of mutations that confer resistance to antiretroviral drugs was examined in 56 drug-naive, human immunodeficiency virus type 1 (HIV-1)-infected individuals from the Army Health Service in Rio de Janeiro, Brazil. No primary protease inhibitor mutations were found, but secondary mutations were observed in 51.2% of the samples. Fourteen percent of the viruses had reverse transcriptase inhibitor-associated mutations. Comparative analysis of protease secondary mutations from four different time periods in drug-naive patients in the city of Rio de Janeiro has indicated constant rates for particular mutations. Changes in CD4 cell counts and HIV viral load over time in subtype B- and non-B-infected drug-naive patients were not significantly different.
authors.affiliation: Seção de Virologia, Instituto de Biologia do Exército, Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Ivone L
authors.initials: IL
authors.lastname: Pires
authors.forename: Marcelo A
authors.initials: MA
authors.lastname: Soares
authors.forename: Francisco A B
authors.initials: FA
authors.lastname: Speranza
authors.forename: Solange K
authors.initials: SK
authors.lastname: Ishii
authors.forename: Maria C G
authors.initials: MC
authors.lastname: Vieira
authors.forename: Maria I F S
authors.initials: MI
authors.lastname: Gouvêa
authors.forename: Maria A A M
authors.initials: MA
authors.lastname: Guimarães
authors.forename: Fátima E
authors.initials: FE
authors.lastname: de Oliveira
authors.forename: Monica M F
authors.initials: MM
authors.lastname: Magnanini
authors.forename: Rodrigo M
authors.initials: RM
authors.lastname: Brindeiro
authors.forename: Amilcar
authors.initials: A
authors.lastname: Tanuri
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000328:Adult; D001483:Base Sequence; D024882:Drug Resistance, Viral; D005260:Female; D015700:HIV Envelope Protein gp41 / Q000235:genetics; D016333:HIV Protease / Q000235:genetics; D054303:HIV Reverse Transcriptase / Q000235:genetics; D015497:HIV-1 / Q000145:classification / Q000187:drug effects*; D006801:Humans; D008297:Male; D008889:Military Personnel; D008969:Molecular Sequence Data; D009154:Mutation
chemical_list: D015700:HIV Envelope Protein gp41; D054303:HIV Reverse Transcriptase; D016333:HIV Protease