Gliosarcoma occurring 8 years after treatment for a medulloblastoma.
METHODS
We present a rare case of a gliosarcoma occurring 8 years following treatment for a medulloblastoma. The patient was diagnosed with a medulloblastoma at the age of 13 years. We considered the possibility of a radiation-induced tumour and present evidence supporting this view. The second cerebral tumour was excised and confirmed to be a gliosarcoma. The tumour bed was re-irradiated with three-dimensional conformal radiotherapy (3DCRT). She remained well for 6 months, after which there was clinicoradiological progression.


CONCLUSIONS
During long-term follow-up of patients with medulloblastomas, the possibility of radiation-induced neoplasms must be borne in mind.
Malde
Rohit
R
Department of Radiation Oncology, Tata Memorial Hospital, Parel, Mumbai-400 012, India.
Jalali
Rakesh
R
Muzumdar
Dattatraya
D
Shet
Tanuja
T
Kurkure
Purna
P
D000293:Adolescent; D000359:Aftercare; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000150:complications* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D018316:Gliosarcoma / Q000209:etiology*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008527:Medulloblastoma / Q000150:complications* / Q000628:therapy; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed / Q000379:methods
D005904:Glial Fibrillary Acidic Protein