title: Support for RGS4 as a susceptibility gene for schizophrenia.
abstract: BACKGROUND
  The gene encoding the regulator of G-protein signaling 4 has recently been associated with susceptibility to schizophrenia. This finding is particularly interesting, because it was replicated within the same study and also because there are functional, positional, and expression data to support the regulator of G-protein signaling 4 as a schizophrenia candidate gene. Although the original report was highly suggestive, a limitation was that the study was conducted on rather small samples.
  
  
  METHODS
  We have examined a large case (n = 709) control (n = 710) sample for association between schizophrenia using four markers investigated in the earlier study, denoted single nucleotide polymorphisms 1, 4, 7, and 18.
  
  
  RESULTS
  We were able to replicate the associations with single nucleotide polymorphisms 4 and 18 that had previously been reported individually and have also identified significant association with haplotypes constructed from single nucleotide polymorphisms 1 and 4.
  
  
  CONCLUSIONS
  Our data give modest support for the hypothesis that the regulator of G-protein signaling 4 is a susceptibility gene for schizophrenia.
authors.affiliation: Department of Psychological Medicine, University of Wales College of Medicine, Cardiff, United Kingdom.
authors.forename: Nigel M
authors.initials: NM
authors.lastname: Williams
authors.forename: Anna
authors.initials: A
authors.lastname: Preece
authors.forename: Gillian
authors.initials: G
authors.lastname: Spurlock
authors.forename: Nadine
authors.initials: N
authors.lastname: Norton
authors.forename: Hywel J
authors.initials: HJ
authors.lastname: Williams
authors.forename: Robin G
authors.initials: RG
authors.lastname: McCreadie
authors.forename: Paul
authors.initials: P
authors.lastname: Buckland
authors.forename: Val
authors.initials: V
authors.lastname: Sharkey
authors.forename: Kodavali V
authors.initials: KV
authors.lastname: Chowdari
authors.forename: Stanley
authors.initials: S
authors.lastname: Zammit
authors.forename: Vishwajit
authors.initials: V
authors.lastname: Nimgaonkar
authors.forename: George
authors.initials: G
authors.lastname: Kirov
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owen
authors.forename: Michael C
authors.initials: MC
authors.lastname: O'Donovan
mesh_terms: D000328:Adult; D000409:Alanine / Q000235:genetics; D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005998:Glycine / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D020710:RGS Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D012559:Schizophrenia / Q000235:genetics*; D013912:Threonine / Q000235:genetics
chemical_list: D020710:RGS Proteins; D012333:RNA, Messenger; C098799:RGS4 protein; D013912:Threonine; D000409:Alanine; D005998:Glycine