Induction of cellular and humoral immunity after aerosol or subcutaneous administration of Edmonston-Zagreb measles vaccine as a primary dose to 12-month-old children.
Infants were immunized by aerosol (10(3.6) plaque-forming units [pfu]/dose) or subcutaneous (sc) (10(4.27) pfu/dose) administration of Edmonston-Zagreb measles vaccine. Measles-specific T cell proliferative responses with a stimulation index of > or =3 developed in 72% of children given aerosol-administered vaccine, compared with 87% given s.c.-administered vaccine (P =.06). Seroconversion rates were 90% after aerosol-administered vaccine and 100% after s.c.-administered vaccine (P=.01), and measles geometric mean titers were 237 milli-international units (mIU) (95% confidence interval [CI], 146-385 mIU) and 487 mIU (95% CI, 390-609 mIU) in each group, respectively (P=.01). Measles-specific T and B cell responses were weaker after aerosol than after sc vaccination, indicating a need to use a higher aerosol dose to achieve optimal immunogenicity.
Wong-Chew
Rosa María
RM
Dept. de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico. rmwong@correo.unam.mx
Islas-Romero
Rocío
R
García-García
Maria de Lourdes
Mde L
Beeler
Judy A
JA
Audet
Susette
S
Santos-Preciado
Jose Ignacio
JI
Gans
Hayley
H
Lew-Yasukawa
Linda
L
Maldonado
Yvonne A
YA
Arvin
Ann M
AM
Valdespino-Gómez
José Luis
JL
D000336:Aerosols; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D006801:Humans; D007223:Infant; D007279:Injections, Subcutaneous; D007371:Interferon-gamma / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008297:Male; D008458:Measles Vaccine / Q000008:administration & dosage / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination
D000336:Aerosols; D000914:Antibodies, Viral; D008458:Measles Vaccine; D007371:Interferon-gamma