title: Effects of radiation on fatty liver and metabolic coronary risk factors among atomic bomb survivors in Nagasaki.
abstract: In order to clarify the basic mechanism(s) linking radiation exposure and coronary heart disease (CHD), we here collected ultrasonographic data on fatty liver and measured levels of metabolic CHD risk factors from November 1990 through October 1992 in 1,517 Nagasaki atomic bomb survivors (575 men and 942 women). Using a cross-sectional study design, we examined the effects of radiation dose on fatty liver and CHD risk factors by means of a multiple logistic regression model. Fatty liver was related to the metabolic CHD risk factors associated with insulin resistance syndrome: obesity, hypertension, hypercholesterolemia, low high density lipoprotein (HDL)-cholesterol, hypertriglyceridemia, and abnormal glucose metabolism. Radiation dose was positively related to fatty liver, low HDL-cholesterol, and hypertriglyceridemia, whereas it had no effects on obesity, hypertension, hypercholesterolemia, or abnormal glucose metabolism. The present results suggested that radiation dose was related to 1) fatty liver, which clustered the metabolic CHD risk factors associated with insulin resistance syndrome and 2) atherogenic lipid profiles. It is suggested that these associations are involved in the basic mechanism(s) linking radiation exposure and CHD.
authors.affiliation: Department of Clinical Studies, Radiation Effects Research Foundation, Nagasaki, Japan. akahoshi@rerf.or.jp
authors.forename: Masazumi
authors.initials: M
authors.lastname: Akahoshi
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Amasaki
authors.forename: Midori
authors.initials: M
authors.lastname: Soda
authors.forename: Ayumi
authors.initials: A
authors.lastname: Hida
authors.forename: Misa
authors.initials: M
authors.lastname: Imaizumi
authors.forename: Eiji
authors.initials: E
authors.lastname: Nakashima
authors.forename: Renju
authors.initials: R
authors.lastname: Maeda
authors.forename: Shinji
authors.initials: S
authors.lastname: Seto
authors.forename: Katsusuke
authors.initials: K
authors.lastname: Yano
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D005234:Fatty Liver / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology*; D015228:Hypertriglyceridemia / Q000453:epidemiology; D007333:Insulin Resistance / Q000528:radiation effects; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009689:Nuclear Warfare; D009765:Obesity / Q000453:epidemiology; D011829:Radiation Dosage; D012307:Risk Factors