title: BOLD signal sign and transient vessels volume variation.
abstract: The purpose of this work was to investigate the relation between BOLD signal sign and transient vessels volume variation induced by apnea. This stimulus consisting of breath holding after inspiration is able to induce a light slowing down in venous blood flow like in a sort of Valsalva maneuver. We observed diffuse negative BOLD responding areas at cortical level and a stronger negative response in correspondence of the main sinuses. These phenomena seem to be unrelated to a specific neural activity, appearing to be expressions of a mechanical variation in the hemodynamics. Our study suggests that particular care must be considered in the interpretation of fMRI findings, especially when patients with vascular-related cerebral diseases are involved.
authors.affiliation: Istituto Neurologico Mediterraneo Neuromed, Pozzilli, (IS), Italy.
authors.forename: G
authors.initials: G
authors.lastname: Garreffa
authors.forename: C
authors.initials: C
authors.lastname: Colonnese
authors.forename: M A
authors.initials: MA
authors.lastname: Macrì
authors.forename: N
authors.initials: N
authors.lastname: Modugno
authors.forename: R
authors.initials: R
authors.lastname: Rocca
authors.forename: V
authors.initials: V
authors.lastname: Calistri
authors.forename: E
authors.initials: E
authors.lastname: De Cesare
authors.forename: E
authors.initials: E
authors.lastname: Venditti
authors.forename: B
authors.initials: B
authors.lastname: Maraviglia
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D002560:Cerebrovascular Circulation; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D010100:Oxygen / Q000097:blood; D012119:Respiration
chemical_list: D010100:Oxygen