title: Alpha-synuclein haplotypes implicated in risk of Parkinson's disease.
abstract: The authors examined four- and six-loci haplotype constructs (from five single nucleotide polymorphisms and three microsatellite regions) of the alpha-synuclein gene in patients with Parkinson's disease (PD) and controls in an ethnic Chinese population. Logistic regression analysis demonstrated an association of NACP-Rep1 (p = 0.002) and L478 (p < 0.0001) with risk of PD after correction for the effects of age, sex, and the other polymorphic loci. Specific four-loci and six-loci haplotypes were significantly associated with an increased or decreased risk of PD.
authors.affiliation: Department of Neurology, Singapore General Hospital, Singapore. gnrtek@sgh.com.sg
authors.forename: E K
authors.initials: EK
authors.lastname: Tan
authors.forename: A
authors.initials: A
authors.lastname: Chai
authors.forename: Y Y
authors.initials: YY
authors.lastname: Teo
authors.forename: Y
authors.initials: Y
authors.lastname: Zhao
authors.forename: C
authors.initials: C
authors.lastname: Tan
authors.forename: H
authors.initials: H
authors.lastname: Shen
authors.forename: V R
authors.initials: VR
authors.lastname: Chandran
authors.forename: M L
authors.initials: ML
authors.lastname: Teoh
authors.forename: Y
authors.initials: Y
authors.lastname: Yih
authors.forename: R
authors.initials: R
authors.lastname: Pavanni
authors.forename: M C
authors.initials: MC
authors.lastname: Wong
authors.forename: K
authors.initials: K
authors.lastname: Puvan
authors.forename: Y L
authors.initials: YL
authors.lastname: Lo
authors.forename: E
authors.initials: E
authors.lastname: Yap
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D015994:Incidence; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D009010:Monte Carlo Method; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016017:Odds Ratio; D010300:Parkinson Disease / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D018570:Risk Assessment; D012846:Singapore / Q000453:epidemiology; D051843:Synucleins; D051844:alpha-Synuclein
chemical_list: D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein