title: Acute myeloid leukemia presenting simultaneously in two siblings.
abstract: The rare occurrence of acute myeloid leukemia simultaneously in two siblings, 3-year male and 1-year female, in the absence of any known predisposing condition is reported. We speculate that an initial in-utero genetic alteration followed by subsequent environmental exposure to some unknown toxin may have resulted in leukemogenesis.
authors.affiliation: Department of Pediatrics, Division of Pediatric Oncology, All India Institute of Medical Sciences, New Delhi 110029, India.
authors.forename: Vandana
authors.initials: V
authors.lastname: Jain
authors.forename: Sameer
authors.initials: S
authors.lastname: Bakhshi
authors.forename: Mei-Yoke
authors.initials: MY
authors.lastname: Chan
authors.forename: L S
authors.initials: LS
authors.lastname: Arya
mesh_terms: D002675:Child, Preschool; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D018570:Risk Assessment; D012720:Severity of Illness Index; D035781:Siblings