[Associated brain anomalies and clinical findings in corpus callosum dysgenesis].
OBJECTIVE
The aim of this study was to evaluate the relationship between the types of the corpus callosum dysgenesis, the associated brain anomalies and clinical findings.


METHODS
We analyzed the MR imaging findings in 169 patients with callosal dysgenesis. Corpus callosum dysgenesis was categorized into agenesis, hypogenesis and hypoplasia. The associated brain anomalies and clinical findings were evaluated.


RESULTS
Associated brain anomalies were observed in 148 patients (87.5%). Twenty-one patients (12.4%) had isolated corpus callosum dysgenesis. Dysgenesis included agenesis in 22 (%13), hypogenesis in 46 (27.2%), and hypoplasia in 101 (59.7%) patients. The clinical findings were most commonly observed in patients with hypoplasia.


CONCLUSIONS
The presence of corpus callosum dysgenesis is a strong indication of possible associated brain anomalies. Corpus callosum dysgenesis and associated brain anomalies should be investigated in children with developmental delay, seizures and microcephaly.
Alkan
Alpay
A
Inönü Universitesi Tip Fakültesi, Turgut Ozal Tip Merkezi, Radyodiagnostik Anabilim Dali, Malatya.
Kutlu
Ramazan
R
Baysal
Tamer
T
Siğirci
Ahmet
A
Altinok
Tayfun
T
Orkan
Ismet
I
Hallaç
Tarik
T
Saraç
Kaya
K
D000015:Abnormalities, Multiple / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D061085:Agenesis of Corpus Callosum; D002648:Child; D003337:Corpus Callosum / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008499:Medical Records; D009421:Nervous System Malformations / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology*; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology