title: Atovaquone/proguanil resistance in Africa: a case report.
abstract: The Atovaquone/proguanil combination has quickly been established as an effective chemoprophylaxis for travellers to areas with chloroquineresistant Plasmodium falciparum malaria. We describe the molecular cause of the first reported case of primary Atovaquone/proguanil resistance observed in our department in a Plasmodium falciparum infected traveller returning from West Africa, and link our findings to other reports of resistance.
authors.affiliation: Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark. kpd@dadlnet.dk
authors.forename: Kim P
authors.initials: KP
authors.lastname: David
authors.forename: Michael
authors.initials: M
authors.lastname: Alifrangis
authors.forename: Ali
authors.initials: A
authors.lastname: Salanti
authors.forename: Lasse S
authors.initials: LS
authors.lastname: Vestergaard
authors.forename: Anita
authors.initials: A
authors.lastname: Rønn
authors.forename: I B
authors.initials: IB
authors.lastname: Bygbjerg
mesh_terms: D000328:Adult; D000349:Africa; D000818:Animals; D053626:Atovaquone; D001426:Bacterial Proteins / Q000235:genetics*; D003573:Cytochrome b Group / Q000235:genetics*; D003718:Denmark; D018432:Drug Resistance, Multiple; D004359:Drug Therapy, Combination; D005293:Ferritins / Q000235:genetics*; D006801:Humans; D016778:Malaria, Falciparum / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009285:Naphthoquinones / Q000008:administration & dosage* / Q000494:pharmacology; D010597:Pharmacogenetics; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics; D016133:Polymerase Chain Reaction; D002727:Proguanil / Q000008:administration & dosage* / Q000494:pharmacology; D018570:Risk Assessment; D014195:Travel; D017211:Treatment Failure
chemical_list: D001426:Bacterial Proteins; D003573:Cytochrome b Group; D009285:Naphthoquinones; D005293:Ferritins; C018032:bacterioferritin; D002727:Proguanil; D053626:Atovaquone