Towards the cellular functions of tumour suppressors.
Many of the documented changes in cellular DNA that occur during tumour development involve activation of proto-oncogenes, but newer evidence has shown that oncogenesis can involve loss or inactivation of a different group of genes, called tumour suppressor genes (TSGs). Molecular analysis of TSGs is revealing that their protein products are involved in cell adhesion, signal transduction, transcription, translation and cell cycle control. Surprisingly, most of the TSG products had not been previously identified in studies of normal cells, so their analysis is contributing not only to our understanding of oncogenesis, but also to basic cell biology. The 'comment' articles in this issue discuss progress towards understanding the cellular functions of TSG products.
Bryant
P J
PJ
Developmental Biology Center, University of California, Irvine, CA 92717, USA.