title: Efficacy of intrathecal morphine in the treatment of baclofen tolerance in a patient on intrathecal baclofen therapy (ITB).
abstract: METHODS
  Case report.
  
  
  OBJECTIVE
  A case report of tolerance to intrathecal baclofen therapy (ITB) treated with intrathecal morphine ('baclofen holiday').
  
  
  METHODS
  Institut Guttmann, Neurorehabilitation Hospital of Barcelona, Spain.
  
  
  METHODS
  A 30-year-old female patient is described with incomplete paraplegia below T6 on the left side and below T8 on the right side, ASIA B, caused by trauma occurring 12 years previously, in whom an intrathecal system had been implanted for baclofen infusion 10 years ago. The patient showed tolerance to baclofen therapy and was treated with intrathecal morphine infusion for 2 weeks. Baclofen infusion resulted in adequate control of spasticity.
authors.affiliation: Institut Guttmann, Neurorehabilitation Hospital of Badalona, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Vidal
authors.forename: P
authors.initials: P
authors.lastname: Gregori
authors.forename: D
authors.initials: D
authors.lastname: Guevara
authors.forename: E
authors.initials: E
authors.lastname: Portell
authors.forename: M
authors.initials: M
authors.lastname: Vallés
mesh_terms: D000328:Adult; D001418:Baclofen / Q000008:administration & dosage*; D004361:Drug Tolerance / Q000502:physiology*; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D009020:Morphine / Q000008:administration & dosage*; D010264:Paraplegia / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D009020:Morphine; D001418:Baclofen