[Neoangiogenesis: from molecular biology to clinical medicine].
Cardiovascular disease is the most common cause of premature death in patients with end-stage renal disease, probably due to a specific "uraemic cardiomyopathy" This article reviews the pathogenesis of cardiac changes in uraemia and particularly the role of an impaired vessel formation. Experimental and autoptic data showed remarkable changes in heart capillarization in renal failure, i.e. a decrease in myocardial capillary supply and a concomitant increase in intercapillary distance. Promoting the formation of new collateral vessels in ischemic tissues using angiogenic growth factors (therapeutic angiogenesis), such as VEGF, constitutes a promising approach for the treatment of uraemic cardiomyopathy.
Odoni
G
G
Istituto di Clinica Medica, Universita' di Heidelberg - Germania.
Amann
K
K
Ritz
E
E
D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D018919:Neovascularization, Physiologic / Q000502:physiology