title: The alkaloids and other constituents from the root and stem of Aristolochia elegans.
abstract: Two new aristolactams, aristolactam E (1) and aristolactam-AIIIa-6-O-beta-D-glucoside (2), three novel benzoyl benzyltetrahydroisoquinoline ether N-oxide alkaloids, aristoquinoline A (3), aristoquinoline B (4), and aristoquinoline C (5), and a new biphenyl ether, aristogin F (6), together with 62 known compounds have been isolated from the root and stem of Aristolochia elegans Mast. The structures of the new natural products were established on the basis of spectral evidence. Some of the isolated compounds were examined for their antioxidative and antityrosinase activities. Occurrence of the isoquinolones, biphenyl ethers, and benzoyl benzyltetrahydroisoquinoline ether alkaloids in the same plant indicated the definite possibility of these metabolites as biotransformation intermediates of bisbenzyltetrahydroisoquinoline alkaloids. This can be useful to solve the catabolic process of bisbenzyltetrahydroisoquinoline alkaloids.
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, ROC.
authors.forename: Li-Shian
authors.initials: LS
authors.lastname: Shi
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.forename: Yao-Lung
authors.initials: YL
authors.lastname: Tsai
authors.forename: Amooru Gangaiah
authors.initials: AG
authors.lastname: Damu
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D030022:Aristolochia / Q000737:chemistry* / Q000378:metabolism; D001713:Biphenyl Compounds / Q000737:chemistry; D002942:Circular Dichroism; D004987:Ethers / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry; D007769:Lactams / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry
chemical_list: D000470:Alkaloids; D001713:Biphenyl Compounds; D004987:Ethers; D005960:Glucosides; D007769:Lactams; D010936:Plant Extracts; D011804:Quinolines; C492855:aristolactam E; C492854:aristolactam-AIIIa-6-O-beta-D-glucoside; C492856:aristoquinoline A; C492857:aristoquinoline B; C492858:aristoquinoline C