Fas deficiency exacerbates cerulein-induced pancreatitis.
Acute pancreatitis results in many deaths each year. Our understanding of pathophysiology is limited. To better understand the impact of apoptosis versus necrosis, we compared cerulein-induced pancreatitis in Fas-deficient (MRL lpr/lpr) versus Fas-sufficient (MRL +/+) mice. Average amylase values in Fas-deficient mice were substantially greater than in Fas-sufficient mouse. Histology graded on edema, inflammation, vacuolization, and necrosis showed greater injury in the Fas-deficient mouse. This finding suggests that the Fas pathway is important in controlling cerulein-induced pancreatitis.
Jeyarajah
D Rohan
DR
Department of Surgery, University of Texas, Southwestern Medical School, Dallas, TX 75390, USA. rohan.jeyarajah@utsouthwestern.edu
Kielar
M
M
Gokaslan
S T
ST
Lindberg
G
G
Lu
C Y
CY
D000208:Acute Disease; D000681:Amylases / Q000097:blood; D000818:Animals; D002108:Ceruletide; D004195:Disease Models, Animal; D051379:Mice; D019463:Mice, Inbred MRL lpr; D009336:Necrosis; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology*; D019014:fas Receptor / Q000235:genetics*
D019014:fas Receptor; D002108:Ceruletide; D000681:Amylases