Low grade gastric mucosa associated lymphoid tissue lymphoma: treatment strategies based on 10 year follow-up.
OBJECTIVE
To deduce strategic guidelines of gastric mucosa associated lymphoid tissue lymphoma (MALTOMA) by evaluating the long-term outcome of patients in respect to various treatment modalities.


METHODS
A total of 55 patients with MALTOMA from May 1992 to August 2002 were retrospectively reviewed.


RESULTS
Complete remission was obtained in 24 (82.8%) of 29 patients treated with anti Helicobacter pylori (H pylori) regimen only. The duration to reach complete remission was 12 months (85 percentile, 2-33 months). Five patients showed complete remission with radiation therapy (26-86 months). Two of them were H pylori treatment failure cases.


CONCLUSIONS
H pylori eradication is an effective primary treatment option for low grade MALTOMA and radiation therapy could be considered in patients with no evidence of H pylori infection or who do not respond to H pylori eradication therapy 12 months after successful eradication.
Lee
Sang Kil
SK
Division of Gastroenterology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Lee
Yong Chan
YC
Chung
Jae Bock
JB
Chon
Chae Yoon
CY
Moon
Young Myoung
YM
Kang
Jin Kyung
JK
Park
In-Suh
IS
Suh
Chang Ok
CO
Yang
Woo Ik
WI
D000328:Adult; D000368:Aged; D016145:Endoscopy, Digestive System; D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology*; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology* / Q000532:radiotherapy*; D008875:Middle Aged; D011706:Pyloric Antrum / Q000382:microbiology / Q000473:pathology; D012074:Remission Induction; D012189:Retrospective Studies; D013276:Stomach Ulcer / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology