title: Chlamydia pneumoniae and future risk in patients with coronary heart disease.
abstract: OBJECTIVE
  To evaluate the association between previous exposure to Chlamydia pneumoniae and future coronary risk in patients with coronary heart disease.
  
  
  METHODS
  A prospective, nested, case-control design was used. The patient sample was derived from a trial study of bezafibrate for the treatment of coronary heart disease. Anti-Chlamydia pneumoniae antibodies (IgG and IgA) in the baseline sera of 136 patients who had coronary events during follow-up (mean 6.2 years) were compared with those in 136 age- and gender-matched patients from the same trial without subsequent coronary events.
  
  
  RESULTS
  Mean titers of IgG and IgA antibodies were similar in cases and controls. The relative odds of future coronary events in patients who were seropositive at baseline were 1.0 (95% CI, 0.54-1.84) for IgG and 0.74 (95% CI, 0.41-1.31) for IgA. The relative odds did not change after adjustment for multiple confounding variables. The risk of future coronary events did not increase with increasing anti-Chlamydia pneumoniae antibody titers.
  
  
  CONCLUSIONS
  Prior exposure to Chlamydia pneumoniae in patients with chronic coronary heart disease is not associated with increased risk of recurrent coronary events.
authors.affiliation: Department of Cardiology, Rabin Medical Center, Beilinson Campus, Petah Tiqva 49 100, Israel. motih@netvision.net.il
authors.forename: Moti
authors.initials: M
authors.lastname: Haim
authors.forename: David
authors.initials: D
authors.lastname: Tanne
authors.forename: Alexander
authors.initials: A
authors.lastname: Battler
authors.forename: Valentina
authors.initials: V
authors.lastname: Boyko
authors.forename: Tamar
authors.initials: T
authors.lastname: Reshef
authors.forename: Uri
authors.initials: U
authors.lastname: Goldbourt
authors.forename: Daniel
authors.initials: D
authors.lastname: Brunner
authors.forename: Yoseph A
authors.initials: YA
authors.lastname: Mekori
authors.forename: Solomon
authors.initials: S
authors.lastname: Behar
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000097:blood / Q000150:complications*; D016993:Chlamydophila pneumoniae; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G