Subependymal giant cell astrocytoma with positive tuberin expression--case report.
An 11-year-old male presented with subependymal giant cell astrocytoma (SEGA) without other manifestations of tuberous sclerosis such as facial angiofibroma, epilepsy, or mental retardation. The diagnosis was "possible tuberous sclerosis complex" (TSC). Total resection of the tumor was performed. Immunohistochemical study revealed positive tuberin expression. In general, loss of tuberin is thought to be critical to the TSC phenotype. Our case demonstrated clear expression of tuberin in the SEGA specimen.
Tabuchi
Sadaharu
S
Department of Neurosurgery, Institute of Neurological Sciences, Tottori University School of Medicine, Yonago, Tottori, Japan. stabuchi@gj8.so-net.ne.jp
Takigawa
Haruo
H
Oka
Akira
A
Mizuguchi
Masashi
M
Horie
Yasushi
Y
Watanabe
Takashi
T
D001254:Astrocytoma / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D001932:Brain Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D002648:Child; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008866:Microsurgery / Q000379:methods; D019635:Neurosurgical Procedures / Q000379:methods; D012097:Repressor Proteins / Q000378:metabolism*; D014057:Tomography, X-Ray Computed; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins
D012097:Repressor Proteins; C000624653:TSC2 protein, human; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins