title: [Indomethacin-induced ileal perforation].
abstract: We present two cases of indomethacin-induced perforation of the distal small intestine. Both patients were male and undergoing oral indomethacin therapy. Both presented acute abdomen with diffuse peritonitis secondary to perforations located in the antimesenteric border of the terminal ileum. Histopathological lesions of the intestinal wall showed transmural infiltration, congestion, and hemorrhage; their severity was related to higher doses and longer duration of indomethacin therapy.
authors.affiliation: Servicio de Cirugía General y Digestiva, Hospital San Agustín de Avilés, Avilés, Asturias, España. baldonedo@telecable.es
authors.forename: R F
authors.initials: RF
authors.lastname: Baldonedo Cernuda
authors.forename: J A
authors.initials: JA
authors.lastname: Alvarez Pérez
authors.forename: I
authors.initials: I
authors.lastname: García Bear
authors.forename: N
authors.initials: N
authors.lastname: Truán Alonso
authors.forename: J I
authors.initials: JI
authors.lastname: Jorge Barreiro
mesh_terms: D000368:Aged; D006801:Humans; D007077:Ileal Diseases / Q000139:chemically induced*; D007213:Indomethacin / Q000009:adverse effects*; D007416:Intestinal Perforation / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged
chemical_list: D007213:Indomethacin