Cyrmenins, new beta-methoxyacrylate inhibitors of the electron transport. Production, isolation, physico-chemical and biological properties.
New antibiotic compounds, named cyrmenins, were isolated from the culture broth of strains of the myxobacteria Cystobacter armeniaca and Archangium gephyra. The compounds belong to the group of beta-methoxyacrylate (MOA) inhibitors and are the first naturally occuring nitrogen-linked MOAs. The cyrmenins show nearly the same antifungal activity as strobilurin A, but are less toxic in a growth inhibition assay with L929 mouse cells. Cyrmenins inhibit NADH oxidation by submitochondrial particles from beef heart. Investigations by difference spectroscopy showed that cyrmenin B1 blocks the electron transport within the cytochrome bc1-segment (complex III) of the respiratory chain.
Sasse
Florenz
F
GBF, German Research Centre for Biotechnology, Department of Natural Product Biology, Mascheroder Weg I, D-38124 Braunschweig, Germany. fsa@gbf.de
Leibold
Thomas
T
Kunze
Brigitte
B
Höfle
Gerhard
G
Reichenbach
Hans
H
D000179:Acrylates / Q000037:antagonists & inhibitors*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D004579:Electron Transport / Q000187:drug effects*; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D009231:Myxococcales; D013329:Structure-Activity Relationship
D000179:Acrylates; D000900:Anti-Bacterial Agents