title: 1-Methyl-3-nitropyridine: an efficient oxidant of NADH in non-enzymatic and enzyme-mediated processes.
abstract: It is shown that NADH can be effectively oxidized by 1-methyl-3-nitropyridine in non-enzymatic and enzyme-mediated processes. Mechanistic issues of these reactions are discussed. These processes seem to contribute to the observed cytotoxicity of 1-methyl-3-nitropyridine. A key role of 1-methyl-3-nitropyridinyl radical formed in the enzyme-mediated processes is emphasized.
authors.affiliation: Institute of Applied Radiation Chemistry, Technical University, Zeromskiego 116, 90-924 Lodz, Poland.
authors.forename: Marzena
authors.initials: M
authors.lastname: Wieczorkowska
authors.forename: Jacek
authors.initials: J
authors.lastname: Zielonka
authors.forename: Joanna
authors.initials: J
authors.lastname: Celińska
authors.forename: Jan
authors.initials: J
authors.lastname: Adamus
authors.forename: Ewa
authors.initials: E
authors.lastname: Ciesielska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Marcinek
authors.forename: Leszek
authors.initials: L
authors.lastname: Szmigiero
authors.forename: Jerzy
authors.initials: J
authors.lastname: Gebicki
mesh_terms: D000818:Animals; D017209:Apoptosis; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005609:Free Radicals / Q000378:metabolism; D007700:Kinetics; D007939:Leukemia L1210; D009243:NAD / Q000378:metabolism*; D009245:NADH Dehydrogenase / Q000378:metabolism; D016877:Oxidants / Q000378:metabolism / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D011726:Pyridinium Compounds / Q000378:metabolism / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism
chemical_list: C488480:1-methyl-3-nitropyridinium; D005609:Free Radicals; D016877:Oxidants; D011726:Pyridinium Compounds; D009243:NAD; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D009245:NADH Dehydrogenase; D010100:Oxygen