title: Becker muscular dystrophy in a patient with Hodgkin's disease.
abstract: Genetic disease often predisposes to neoplastic processes because of either alterations in both oncogenes and tumor suppressor genes or imbalances in the cell cycle. The authors present the case of a 15-year-old boy with Hodgkin's disease associated with Becker muscular dystrophy. Becker muscular dystrophy is an X-linked neuromuscular disease due to in-frame mutations in the dystrophin gene, and it is considered a milder variant of Duchenne muscular dystrophy. In most patients with Becker muscular dystrophy, the myopathic process affects the myocardium, leading to cardiomyopathy.
authors.affiliation: Pediatric Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Cereda
authors.forename: Graziella
authors.initials: G
authors.lastname: Cefalo
authors.forename: Monica
authors.initials: M
authors.lastname: Terenziani
authors.forename: Serena
authors.initials: S
authors.lastname: Catania
authors.forename: Franca
authors.initials: F
authors.lastname: Fossati-Bellani
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003402:Creatine Kinase / Q000097:blood; D016189:Dystrophin / Q000032:analysis; D004562:Electrocardiography; D006689:Hodgkin Disease / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000473:pathology; D020388:Muscular Dystrophy, Duchenne / Q000150:complications* / Q000175:diagnosis*; D011859:Radiography; D012074:Remission Induction
chemical_list: D016189:Dystrophin; D003402:Creatine Kinase