[Adjuvant therapy concepts in advanced stomach carcinoma. Future treatment not without irradiation?].
Perforation of the wall of the stomach, or positive lymph nodes appreciably worsens the prognosis of resected gastric carcinoma. In such a situation, neither adjuvant chemotherapy [12] nor optimal lymph node resection achieves a significant improvement in overall survival [5-8]. In contrast, a significant benefit of adjuvant radiochemotherapy after curative resection of advanced gastric carcinoma has been demonstrated. Thus, standardized postoperative radiochemotherapy should be applied after standardized surgery with a D1 resection. Optimal supportive treatment, that is, at least 1500 kcal/day, appropriate treatment of reflux or dumping symptoms, and supplementation for iron, vitamin B12 and calcium deficiency, is mandatory, if therapeutic success is not to be compromised [13,14].
Schendera
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Radioonkologische Klinik, Städt. Klinikum Kemperhof, Koblenz.
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D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision; D020360:Neoadjuvant Therapy; D011880:Radiotherapy Planning, Computer-Assisted; D018714:Radiotherapy, Adjuvant; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D015996:Survival Rate