title: Intraosseous intraneural perineurioma: report of a case with morphological, immunohistochemical and FISH study.
abstract: We report a case of an intramandibular intraneural perineurioma developed in the left dentary nerve. This tumour is rare and shows a typical histological, immunohistochemical and ultrastructural appearance: concentric whorls of perineurial cells EMA+ and PS100- around nerve fibers. This tumour must be distinguished from extraneural or soft tissue perineurioma, also composed of perineurial cells, with distinct clinical presentation and histological appearance, and from localized hypertrophic neuropathy, a reactive process frequently identified with intraneural perineurioma. Cytogenetic evidence for the neoplastic nature of this tumour is also presented in this report.
authors.affiliation: Departament d'Anatomia Patològica, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, España. phuguet@cs.vhebron.es
authors.forename: Pere
authors.initials: P
authors.lastname: Huguet
authors.forename: Javier
authors.initials: J
authors.lastname: de la Torre
authors.forename: Judith
authors.initials: J
authors.lastname: Pallarès
authors.forename: Marta
authors.initials: M
authors.lastname: Carrera
authors.forename: Francesc
authors.initials: F
authors.lastname: Soler
authors.forename: Blanca
authors.initials: B
authors.lastname: Espinet
authors.forename: Daniel
authors.initials: D
authors.lastname: Malet
mesh_terms: D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008339:Mandibular Neoplasms / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D018317:Nerve Sheath Neoplasms / Q000235:genetics / Q000473:pathology*