title: Perinatal changes of brain-derived neurotrophic factor in pre- and fullterm neonates.
abstract: BACKGROUND
  Brain-derived neurotrophic factor (BDNF) is abundant in brain and peripheral nerves, affects normal development, growth and survival and is implicated in immune response.
  
  
  OBJECTIVE
  To determine in single preterm (P) and fullterm (F) neonates, circulating intra- and extrauterine levels of BDNF, supposingly reflecting their neuronal and immune maturity.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Thirty healthy, appropriate for gestational age (AGA) F (mean gestational age 39.2+/-1.4 weeks), 15 healthy AGA P (29.4+/-1.3 weeks), and their mothers.
  
  
  METHODS
  BDNF was measured by enzyme immunoassay methods in the serum of: mothers at the first stage of labor (MS), the umbilical cord (UC) and the neonates on days 1 (N1) and 4 (N4) postpartum.
  
  
  RESULTS
  Levels of BDNF in (a). FMS did not differ from PMS, but both were significantly higher than respective (F or P) UC, N1 and N4 (p ranging from <0.01 to <0.001), (b). FUC, FN1 and FN4 were significantly higher than PUC (p<0.001), PN1 (p<0.03) and PN4 (p<0.02), respectively, (c). PN1 increased significantly as compared to PUC (p<0.05).
  
  
  CONCLUSIONS
  Higher BDNF MS levels may reflect the mature nervous and immune systems of mothers. Higher BDNF levels in F than P may also be due to advanced maturity in the former. Increased BDNF levels in PN1 as compared to PUC may indicate stimulation of immune response with exposure to antigenic stimuli from the extrauterine environment. Nevertheless, this stimulation is insufficient in P, who by decreasing N4 levels are by far less protected than F.
authors.affiliation: 2nd Department of Obstetrics and Gynecology, University of Athens, 19, Soultani str, GR-10682, Athens, Greece. malamitsi@aias.gr
authors.forename: Ariadne
authors.initials: A
authors.lastname: Malamitsi-Puchner
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Economou
authors.forename: Ourania
authors.initials: O
authors.lastname: Rigopoulou
authors.forename: Theodora
authors.initials: T
authors.lastname: Boutsikou
mesh_terms: D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007234:Infant, Premature / Q000097:blood*; D008297:Male; D008423:Maternal Age; D049590:Postpartum Period; D011247:Pregnancy / Q000097:blood*; D018566:Pregnancy, High-Risk; D011446:Prospective Studies
chemical_list: D019208:Brain-Derived Neurotrophic Factor