Neonatal 5-hydroxytryptamine depletion induces depressive-like behavior in adult rats.
The influence of neonatal serotonergic lesion on adult behavior in locomotor and depression models was studied in male Wistar rats. When 3-day-old rats were injected intracisternally with 5,7-dihydroxytryptamine (5,7-DHT), a marked depletion of brain 5-HT was observed when animals were killed 3 months after the treatment. Brain catecholamine content was generally not changed by neurotoxin treatment. The behavioral consequence of intracisternal 5,7-DHT administration to developing rats consisted in reduction of adult rats' activity in the forced swimming test. Both desipramine, and, to the lesser extent, fluoxetine, reversed 5,7-DHT-induced immobility of animals.
Kostowski
Wojciech
W
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Sobieskiego 9, PL 02-957 Warszawa, Poland.
Krzaścik
Paweł
P
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D003863:Depression / Q000523:psychology*; D005260:Female; D008297:Male; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000172:deficiency* / Q000378:metabolism; D018490:Serotonin Agents / Q000494:pharmacology; D013550:Swimming
D018490:Serotonin Agents; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin