title: The NP-C gene: a key to pathways of intracellular cholesterol transport.
abstract: Elucidation of the pathways for intracellular transport of cholesterol is an important yet elusive goal in cell biology. Analysis of the cellular defects in the human disease Niemann-Pick C (NP-C) is providing insights into this problem. Cholesterol derived from low-density lipoprotein accumulates in lysosomes of NP-C cells, apparently because intracellular movement of such cholesterol is blocked. Identification of the NP-C gene should provide crucial molecular clues to the mechanism of cholesterol transport within cells.
authors.affiliation: Molecular and Cellular Pathophysiology Section, Developmental and Metabolic Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: P G
authors.initials: PG
authors.lastname: Pentchev
authors.forename: E J
authors.initials: EJ
authors.lastname: Blanchette-Mackie
authors.forename: E A
authors.initials: EA
authors.lastname: Dawidowicz