title: How to find "missing" genes.
abstract: Assigning function to "new" proteins is frequently the rate-determining step for deciphering metabolic pathways and regulatory networks. Osterman and Begley break down this barrier by demonstrating that comparative analyses of microbial genomes is a powerful strategy for identifying pathway components.
authors.affiliation: Department of Biochemistry, University of Illinois, 415 Roger Adams Laboratory, 600 S Mathews Avenue, Urbana, IL 61801, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Gerlt
mesh_terms: D001419:Bacteria / Q000201:enzymology / Q000235:genetics* / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D005798:Genes, Bacterial / Q000235:genetics*; D016680:Genome, Bacterial; D023281:Genomics / Q000379:methods*; D015394:Molecular Structure; D009243:NAD / Q000096:biosynthesis* / Q000378:metabolism; D017378:Quinolinic Acid / Q000737:chemistry / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D009243:NAD; D017378:Quinolinic Acid