title: [Clinico-immunologic monitoring of HIV-infected patients: comparative analysis of indicators, characterizing development of the disease].
abstract: The paper contains the results of a 15-year monitoring (since 1986 to 2001) of HIV-infected patients followed up at the clinic of the Institute of Immunology, Federal Department "Medbioextrem", Russia's Health Ministry. An analysis of a category of HIV-infected persons, who practiced the intravenous consumption of drugs since 1997 to 2001, revealed not only concomitant multi-virus infections (hepatitis C--68%, hepatitis B--48%, herpes 41%, fungal infections--66% and bacterial infections--46%) but also lesions (up to 70%) in the gastrointestinal tract and in the hepatic-cellular and hepatic-biliary systems. It was established that, when only immunological indices are taken account of in presence of multi-virus infections, it does not ensure an adequate evaluation of an HIV-patient condition. The below biochemical parameters must be necessarily taken into consideration: activity of alanine aminotransferase, aspartate aminotransferase and of alkaline phosphatase. The changes in the biochemical parameters were shown to be essentially higher in HIV patients with hepatitis C virus (HCV) even during the 2 initial follow-up years, when the immunological parameters are in the norm or even insignificantly below it. A comparative analysis of dynamic clinical, immunological and biochemical indices was made within the case study for the purpose of defining the prognostic criteria for HIV progression scenarios.
authors.forename: M N
authors.initials: MN
authors.lastname: Papuashvili
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Shchelkanov
mesh_terms: D018450:Disease Progression; D015658:HIV Infections / Q000150:complications / Q000276:immunology* / Q000473:pathology; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008111:Liver Function Tests; D008991:Monitoring, Physiologic / Q000379:methods*