title: The oral environment: the challenge for antimicrobials in oral care products.
abstract: For any antibacterial/ anti-plaque system from an oral care product to be effective, it must firstly be delivered and retained at relevant sites in the oral cavity and secondly, remain active within the chosen formulation to successfully target the biofilm cells within dental plaque. This must include inhibition of the growth and metabolism of relevant organisms associated with disease. This review will concentrate on understanding the environmental conditions in which such oral care products must work and summarise the activity within the oral cavity of the main antibacterial and anti-plaque agents in common oral care products, namely chlorhexidine, essential oils, metal salts and Triclosan. Routes to further enhance the activity of these products, together with the use of relatively novel formats such as confectionery products to provide added consumer oral health benefits will be considered.
authors.affiliation: Unilever Oral Care, Quarry Road East, Bebington, Wirral, UK. Melanie.Brading@Unilever.com
authors.forename: M G
authors.initials: MG
authors.lastname: Brading
authors.forename: P D
authors.initials: PD
authors.lastname: Marsh
mesh_terms: D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D018441:Biofilms / Q000187:drug effects; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control; D006801:Humans; D009055:Mouth / Q000382:microbiology*; D009910:Oral Hygiene
chemical_list: D000891:Anti-Infective Agents, Local