title: Use of an in-field-of-view shield to improve count rate performance of the single crystal layer high-resolution research tomograph PET scanner for small animal brain scans.
abstract: The count rate performance of the single LSO crystal layer high-resolution research tomograph (HRRT-S) PET scanner is limited by the processing speed of its electronics. Therefore, the feasibility of using an in-field-of-view (in-FOV) shield to improve the noise equivalent count rates (NECR) for small animal brain studies was investigated. The in-FOV shield consists of a lead tube of 12 cm length, 6 cm inner diameter and 9 mm wall thickness. It is large enough to shield the activity in the body of a rat or mouse. First, the effect of this shield on NECR was studied. Secondly, a number of experiments were performed to assess the effects of the shield on the accuracy of transmission scan data and, next, on reconstructed activity distribution in the brain. For activities below 150 MBq NECR improved only by 5-10%. For higher activities NECR maxima of 1.2E4 cps at 200 MBq and 2.2E4 cps at 370 MBq were found without and with shield, respectively. Listmode data taken without shield, however, were corrupted for activities above 75 MBq due to data overrun problems (time tag losses) of the electronics. When the shield was used data overrun was avoided up to activities of 150 MBq. For the unshielded part of the phantom, transmission scan data were the same with and without shield. The estimated scatter contribution was approximately 8.5% without and 5.5% with shield. Reconstructed emission data showed a difference up to 5% in the unshielded part of the phantom at 5 mm or more from the edge of the shielding. Of this 5% about 3% results from the difference in the uncorrected scatter contribution. In conclusion, an in-FOV shield can be used successfully in an HRRT PET scanner to improve NECR and accuracy of small animal brain studies. The latter is especially important when high activities are required for tracers with low brain uptake or when multiple animals are scanned simultaneously.
authors.affiliation: PET Center, VU University Medical Center, Amsterdam, The Netherlands. r.boellaard@vumc.nl
authors.forename: R
authors.initials: R
authors.lastname: Boellaard
authors.forename: H W A M
authors.initials: HW
authors.lastname: de Jong
authors.forename: C F M
authors.initials: CF
authors.lastname: Molthoff
authors.forename: F
authors.initials: F
authors.lastname: Buijs
authors.forename: M
authors.initials: M
authors.lastname: Lenox
authors.forename: R
authors.initials: R
authors.lastname: Nutt
authors.forename: A A
authors.initials: AA
authors.lastname: Lammertsma
mesh_terms: D000818:Animals; D016477:Artifacts; D001921:Brain / Q000000981:diagnostic imaging*; D019544:Equipment Failure Analysis / Q000295:instrumentation*; D007089:Image Enhancement / Q000295:instrumentation*; D051379:Mice; D019047:Phantoms, Imaging; D011786:Quality Control; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014055:Tomography, Emission-Computed / Q000295:instrumentation*; D014159:Transducers