Usefulness of low-level laser for control of painful stomatitis in patients with hand-foot-and-mouth disease.
OBJECTIVE
The aim of this study was to evaluate the usefulness of low-level laser therapy (LLLT) for the control of painful stomatitis in patients with hand-foot-and-mouth disease (HFMD).


BACKGROUND
LLLT has been successfully applied to various painful oral mucosal diseases, although there have been few reports on LLLT for HFMD patients.


METHODS
Through a randomized double-blind placebo controlled trial, the painful period of HFMD stomatitis was compared between the LLLT group (n=11) and the placebo LLLT one (n=9), which had similar clinical backgrounds. The LLLT parameters supplied were as follows: wavelength of 830 nm, power of 30 mW, frequency of 30 Hz, and energy output of 1.1 J/cm2. Acceptability and safety of the treatment were also evaluated.


RESULTS
The painful period was shorter in the LLLT group (4.0 +/- 1.3 days) than in the placebo LLLT one (6.7 +/- 1.6 days) with a statistically significant difference (p<0.005). The treatment was judged acceptable for 90.0% (18 of 20) of patients. No adverse events were observed in any cases.


CONCLUSIONS
LLLT is a useful method to control HFMD stomatitis by shortening the painful period, with its high acceptability and lack of adverse events.
Toida
Makoto
M
Department of Oral and Maxillofacial Sciences, Gifu University School of Medicine, Gifu, Japan. toida@cc.gifu-u.ac.jp
Watanabe
Fumio
F
Goto
Kazumi
K
Shibata
Toshiyuki
T
D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006232:Hand, Foot and Mouth Disease / Q000150:complications*; D006801:Humans; D028022:Low-Level Light Therapy; D008297:Male; D013280:Stomatitis / Q000209:etiology / Q000532:radiotherapy*; D016896:Treatment Outcome