title: SENV infection in HIV-positive patients: prevalence, subtype characterization, and impact on HIV disease progression.
abstract: Among 165 HIV-infected patients, prevalence of SEN virus (SENV) infection was 51.5%, with subtype A predominance and unique SENV variant (67%), but also SENV superinfections with multiple variants were frequent. High prevalence, superinfection and broad SENV subtype diversification have been demonstrated, all linked to intravenous drug use (IVDU) as a risk factor for HIV acquisition. At multivariate analysis, SENV infection did not appear to have any negative impact on survival, while a possible protective effect needs further investigation.
authors.affiliation: Department of Infectious and Tropical Diseases, Spedali Civili of Brescia, 25123, Italy. kaeniaquiros@hotmail.com
authors.forename: Eugenia
authors.initials: E
authors.lastname: Quiros-Roldan
authors.forename: Carlo
authors.initials: C
authors.lastname: Torti
authors.forename: Luisa
authors.initials: L
authors.lastname: Imberti
authors.forename: Salvatore
authors.initials: S
authors.lastname: Casari
authors.forename: Vicente
authors.initials: V
authors.lastname: Soriano
authors.forename: Francesca
authors.initials: F
authors.lastname: Moretti
authors.forename: Silvia
authors.initials: S
authors.lastname: Pirovano
authors.forename: Giampiero
authors.initials: G
authors.lastname: Carosi
mesh_terms: D000328:Adult; D004267:DNA Viruses / Q000145:classification / Q000235:genetics*; D018450:Disease Progression; D015658:HIV Infections / Q000150:complications* / Q000473:pathology; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D015819:Substance Abuse, Intravenous / Q000150:complications*