Regulation of the phagocyte respiratory burst by small GTP-binding proteins.
Bacteria phagocytosed by leukocytes are killed and degraded by toxic oxygen metabolites produced in the phagosome via an NADPH oxidase. NADPH oxidase activity is regulated by small GTP-binding proteins in response to phagocytic stimuli. In this review, Gary Bokoch focuses on the role of Rac in regulating this important phagocytic process.
Bokoch
G M
GM
Depts of Immunology and Cell Biology, The Scripps Research Institute, 10666 N Torrey Pines Road, La Jolla, CA 92037, USA.