title: Regulation of TLR signaling and inflammation by SOCS family proteins.
abstract: Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. These cytokines exert their biological functions through Janus tyrosine kinases and signal transducer and activator of transcription factors. The cytokine-inducible Src homology 2 protein (CIS) and suppressors of cytokine signaling (SOCS) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this short review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in Toll-like receptor signal regulation and inflammatory diseases.
authors.affiliation: Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Fukuoka, Japan. yakihiko@bioreg.kyushu-u.ac.jp
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yoshimura
authors.forename: Hiroyuki Mori Masanobu
authors.initials: HM
authors.lastname: Ohishi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Aki
authors.forename: Toshikatsu
authors.initials: T
authors.lastname: Hanada
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D016207:Cytokines / Q000276:immunology; D006801:Humans; D017874:Immediate-Early Proteins / Q000502:physiology; D007111:Immunity, Cellular; D007249:Inflammation / Q000276:immunology*; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D012097:Repressor Proteins / Q000502:physiology*; D015398:Signal Transduction; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D051193:Toll-Like Receptors
chemical_list: D002352:Carrier Proteins; D016207:Cytokines; D017874:Immediate-Early Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D012097:Repressor Proteins; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins; D051193:Toll-Like Receptors; C108944:SOCS1 protein, human