[Association of small, dense low density lipoprotein with stroke].
OBJECTIVE
To investigate the relationship between small, dense LDL (sLDL) and stroke in Chinese population.


METHODS
The plasma level of sLDL was examined by 2% - 16% nondenatured gradient gel electrophoresis in 204 patients with stroke, including 103 cases of ischemic cerebral infarction (ICI), 51 cases of lacunar infarction (LI), and 50 cases of subcortical hemorrhage (SH), and in 341 sex- and age-matched controls in China. Traditional risk factors for stroke were investigated as well.


RESULTS
The plasma level of sLDL was significantly higher in patients with ICI and LI (54 +/- 8% and 52 +/- 7%) than in the controls (47 +/- 11%, both P < 0.01). However, the plasma sLDL of the CH patients was 50 +/- 9%, not significantly different from that of the controls (P > 0.05). Multiple stepwise regression analysis showed that sLDL was significantly associated with systolic blood pressure, age, and the levels of triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol (all P < 0.05). Multivariate logistic regression analysis showed that those with sLDL > 50% had increase of risk of ischemic cerebral infarction (OR = 3.1, 95% CI 1.649 - 5.691, P < 0.001) independent of other risk factors. The relationship between sLDL abnormality and LI and between sLDL abnormality and SH had no statistical significance (both P > 0.05).


CONCLUSIONS
sLDL is significantly associated with ischemic cerebral infarction independent of other risk factors in Chinese population. sLDL may be a new marker for stroke at least in this Chinese population.
Liu
Xiao-ning
XN
Sino-German Laboratory for Molecular Medicine, Fuwai Cardiovascular Hospital, Chinese Academy of Medical Sciences, Beijing 100037 China.
Gao
Yan
Y
Ye
Jue
J
Wang
Dao-wen
DW
Liao
Yu-hua
YH
Ma
Ai-qun
AQ
Zhu
Zhi-ming
ZM
Zhao
Bing-rang
BR
Zhao
Ji-zong
JZ
Hui
Ru-tai
RT
D000368:Aged; D002543:Cerebral Hemorrhage / Q000097:blood; D002544:Cerebral Infarction / Q000097:blood; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000209:etiology
D008077:Lipoproteins, LDL