Prevalence of human immunodeficiency virus drug resistance mutations and subtypes in drug-naive, infected individuals in the army health service of Rio de Janeiro, Brazil.
The prevalence of mutations that confer resistance to antiretroviral drugs was examined in 56 drug-naive, human immunodeficiency virus type 1 (HIV-1)-infected individuals from the Army Health Service in Rio de Janeiro, Brazil. No primary protease inhibitor mutations were found, but secondary mutations were observed in 51.2% of the samples. Fourteen percent of the viruses had reverse transcriptase inhibitor-associated mutations. Comparative analysis of protease secondary mutations from four different time periods in drug-naive patients in the city of Rio de Janeiro has indicated constant rates for particular mutations. Changes in CD4 cell counts and HIV viral load over time in subtype B- and non-B-infected drug-naive patients were not significantly different.
Pires
Ivone L
IL
Seção de Virologia, Instituto de Biologia do Exército, Departamento de Genética, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Soares
Marcelo A
MA
Speranza
Francisco A B
FA
Ishii
Solange K
SK
Vieira
Maria C G
MC
Gouvêa
Maria I F S
MI
Guimarães
Maria A A M
MA
de Oliveira
Fátima E
FE
Magnanini
Monica M F
MM
Brindeiro
Rodrigo M
RM
Tanuri
Amilcar
A
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000328:Adult; D001483:Base Sequence; D024882:Drug Resistance, Viral; D005260:Female; D015700:HIV Envelope Protein gp41 / Q000235:genetics; D016333:HIV Protease / Q000235:genetics; D054303:HIV Reverse Transcriptase / Q000235:genetics; D015497:HIV-1 / Q000145:classification / Q000187:drug effects*; D006801:Humans; D008297:Male; D008889:Military Personnel; D008969:Molecular Sequence Data; D009154:Mutation
D015700:HIV Envelope Protein gp41; D054303:HIV Reverse Transcriptase; D016333:HIV Protease