Cholesterol changes in coronary patients after a short behavior modification program.
Serum cholesterol changes after an 8-week behavior modification program for patients with coronary artery disease (CAD) were studied in a randomized controlled clinical trial. Acute myocardial infarction (AMI) or coronary artery bypass grafting (CABG) patients were randomly assigned to the intervention (N = 94) or to usual care (N = 90). After 9 months' follow-up the intervention was effective in reducing total cholesterol and LDL cholesterol levels, particularly in patients with high baseline lipid levels. After correcting for changes in dose of statins during follow-up, effects were weakened, but for patients with high baseline cholesterol levels favorable effects remained. In these patients, the intervention group showed a decline of total cholesterol and LDL cholesterol levels of 20% and 29%, respectively, compared to a 12% and 19% reduction in the control group (p <.01). These effects could not be explained by changes in dietary fat consumption. An unexpected finding was a lower increase in HDL cholesterol in the intervention group than in the control group.
Sebregts
Ellen H
EH
Department of Medical, Clinical and Experimental Psychology, Maastricht University, Maastricht, The Netherlands. ehwj.sebregts@adhesie.nl
Falger
Paul R
PR
Bär
Frits W
FW
Kester
Arnold D
AD
Appels
Ad
A
D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D001521:Behavior Therapy / Q000379:methods*; D002784:Cholesterol / Q000009:adverse effects / Q000097:blood*; D003131:Combined Modality Therapy; D001026:Coronary Artery Bypass / Q000523:psychology; D003324:Coronary Artery Disease / Q000178:diet therapy* / Q000188:drug therapy / Q000523:psychology; D018752:Diet, Fat-Restricted; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000178:diet therapy* / Q000188:drug therapy / Q000523:psychology; D009426:Netherlands; D010353:Patient Education as Topic; D010814:Physical Therapy Department, Hospital; D012064:Relaxation Therapy; D013315:Stress, Psychological / Q000150:complications / Q000628:therapy*
D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002784:Cholesterol