[Effects of L-arginine on the function of platelet aggregation during hepatic ischemia/reperfusion injury].
OBJECTIVE
To explore the effects of L-arginine (L-Arg) on the function of platelet aggregation during hepatic ischemia-reperfusion injury (HIRI).


METHODS
The changes in maximum aggregating rate of circulating platelets (Pt(max)), its maximum aggregating time (PtT) as well as its aggregating slopes (PtS) were measured. Effects of L-Arg on those parameters were observed during HIRI in 20 rabbits and 18 patients who were scheduled for elective hepatic surgery.


RESULTS
Pt max and PtS all increased significantly (P<0.05 and P<0.01), while PtT decreased remarkably (both P<0.05) during HIRI of rabbits and patients. After treatment with L-Arg, the abnormal changes of parameters as above were all alleviated remarkably (P<0.05 and P<0.01).


CONCLUSIONS
It is indicated that L-Arg can effectively regulate the function of platelet aggregation during HIRI.
Wang
Wan-tie
WT
Department of Pathophysiology, Wenzhou Medical College, Wenzhou 325027, Zhejiang, China.
Lin
Li-na
LN
Pan
Xue-rong
XR
Xu
Zheng-jie
ZJ
D000328:Adult; D000818:Animals; D001120:Arginine / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D015427:Reperfusion Injury / Q000097:blood* / Q000503:physiopathology / Q000517:prevention & control
D001120:Arginine