title: The relationship between cerebral blood flow and cognitive function in patients with brain insult of various etiology.
abstract: The relationship between the mean cerebral blood flow (CBF) and cognitive function was investigated in patients with brain insult. This study included 72 patients aged 24-85 years treated for the following diseases: cerebral infarction (21), intracerebral hemorrhage (4), subarachnoid hemorrhage (2), brain tumor (14), cerebral contusion (12), normal pressure hydrocephalus (13), Alzheimer's disease (2), and others (4). First-pass radionuclide angiography using Technetium-99m hexamethylpropylene amine oxime (99mTc-HMPAO) was performed for the measurement of the mean CBF, and the Sturb-Black Mental Status Examination for the neuropsychological evaluation. The mean CBF and the score of the neuropsychological test were significantly reduced compared with those of the age-matched controls. Regardless of etiology, the mean CBF and the score of neuropsychological test were significantly reduced, and a significant correlation was observed except for the patients with cerebral contusion. The quantitative measurement of CBF using 99mTc-HMPAO is reliable to estimate the neuropsychological state.
authors.affiliation: Department of Neurosurgery, Yokohama University School of Medicine, Yokohama, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Shiraishi
authors.forename: Chia-Cheng
authors.initials: CC
authors.lastname: Chang
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kanno
authors.forename: Isao
authors.initials: I
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001776:Blood Circulation Time / Q000379:methods; D001927:Brain Diseases / Q000150:complications* / Q000209:etiology; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime