title: Linguistic and gait disturbance in a child with Laurence-Moon-Biedl syndrome: left temporal and parietal lobe hypoplasia.
abstract: Laurence-Moon-Biedl syndrome is an autosomal recessive disorder characterized by retinitis pigmentosa, obesity, polydactyly, hypogenitalism, mental retardation, and renal abnormalities. We report the linguistic and gait disorders in a child with Laurence-Moon-Biedl syndrome associated with left temporal and parietal hypoplasia as determined by magnetic resonance imaging. Our patient was mildly mentally retarded, scoring better on the performance subtest than on the verbal subtest. He received serial assessments for developmental, language, speech, and gait functions, before and after rehabilitation, at age 4.5 and 6 yr, respectively. After comprehensive rehabilitation, the boy achieved improvement in speech, language, fine motor, and gait functions. Early comprehensive rehabilitation programs seem beneficial for improving functional development for children with Laurence-Moon-Biedl syndrome.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Chang Gung Memorial and Childrens Hospital, Tao-Yuan, Taiwan.
authors.forename: Chia-Ling
authors.initials: CL
authors.lastname: Chen
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Chung
authors.forename: Pao-Tsai
authors.initials: PT
authors.lastname: Cheng
authors.forename: Chia-Hui
authors.initials: CH
authors.lastname: Chen
authors.forename: Mei-Hui
authors.initials: MH
authors.lastname: Chen
mesh_terms: D002675:Child, Preschool; D005684:Gait; D006801:Humans; D007806:Language Disorders / Q000209:etiology* / Q000534:rehabilitation; D007849:Laurence-Moon Syndrome / Q000503:physiopathology* / Q000534:rehabilitation; D008297:Male