title: Features of the metabolic syndrome after childhood craniopharyngioma.
abstract: Obesity and multiple pituitary hormone deficiency are common complications after surgery for childhood craniopharyngioma. We hypothesized that post craniopharyngioma surgery, children are at high risk for the metabolic syndrome, including insulin resistance due to excess weight gain and GH deficiency. This study characterized body composition (anthropometry and dual energy x-ray absorptiometry) and metabolic outcomes in 15 children (10 males and 5 females; age, 12.2 yr; range, 7.2-18.5 yr) after surgical removal of craniopharyngioma. In 9 subjects, outcomes were compared with those of healthy age-, sex-, body mass index-, and pubertal stage-matched controls. Insulin sensitivity was measured by 40-min iv glucose tolerance test. Seventy-three percent of subjects were overweight or obese. Sixty-six percent had normal growth velocity without GH treatment. Subjects had increased abdominal adiposity (P = 0.008) compared with controls. However, there was no significant difference in total body fat. Subjects had higher fasting triglycerides (P = 0.02) and lower high density lipoprotein cholesterol to total cholesterol ratio (P = 0.015). Insulin sensitivity was equally reduced for subjects and controls (P = 0.86). After craniopharyngioma removal, patients had more features of the metabolic syndrome compared with controls. This could be a result of hypothalamic damage causing obesity and GH deficiency. Further studies exploring predictors of the metabolic syndrome after craniopharyngioma surgery are required.
authors.affiliation: Institute of Endocrinology and Diabetes, The Children's Hospital at Westmead, Westmead, New South Wales 2145, Australia. shubhas@chw.edu.au
authors.forename: S
authors.initials: S
authors.lastname: Srinivasan
authors.forename: G D
authors.initials: GD
authors.lastname: Ogle
authors.forename: S P
authors.initials: SP
authors.lastname: Garnett
authors.forename: J N
authors.initials: JN
authors.lastname: Briody
authors.forename: J W
authors.initials: JW
authors.lastname: Lee
authors.forename: C T
authors.initials: CT
authors.lastname: Cowell
mesh_terms: D000005:Abdomen; D000273:Adipose Tissue; D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D015992:Body Mass Index; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003397:Craniopharyngioma / Q000601:surgery*; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D019382:Human Growth Hormone / Q000172:deficiency / Q000627:therapeutic use; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D020738:Leptin / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D009765:Obesity / Q000453:epidemiology; D010911:Pituitary Neoplasms / Q000601:surgery*; D011183:Postoperative Complications; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D007328:Insulin; D020738:Leptin; D014280:Triglycerides; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D002784:Cholesterol