Clinical profile and treatment outcome of livedoid vasculitis: a case series.
BACKGROUND
Livedoid vasculitis is a painful ulcerative condition affecting the legs that is often difficult to treat. In this case series, the clinical profile of 6 patients with livedoid vasculitis and their treatment response to aspirin and pentoxifylline are reported.


METHODS
This is an open trial. Investigations to exclude secondary causes of livedoid vasculitis were done. Skin biopsies were performed for histology and direct immunofluorescence. Four patients were treated with pentoxifylline and 2 with aspirin. Response to treatment was assessed at the third and sixth weeks. Thereafter, treatment was individualised according to each patient's clinical response.


RESULTS
Only 1 out of 6 patients had a good response. This patient was treated with pentoxifylline. Most patients required treatment with drugs such as prednisolone, colchicine and azathioprine to control disease activity after the trial period.


CONCLUSIONS
Pentoxifylline or aspirin did not result in significant improvement for most of our patients when used alone. Combination with immunosuppressive treatment yielded better results.
Lee
S S
SS
National Skin Centre, 1 Mandalay Road, Singapore 308205. joycelee@nsc.gov.sg
Ang
P
P
Tan
S H
SH
D000328:Adult; D001241:Aspirin / Q000627:therapeutic use; D003078:Colchicine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006074:Gout Suppressants / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010431:Pentoxifylline / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D014657:Vasculitis / Q000188:drug therapy*
D006074:Gout Suppressants; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin; D010431:Pentoxifylline; D003078:Colchicine