title: HTTM, a horizontally transferred transmembrane domain.
abstract: Sequence analysis of vitamin K-dependent gamma-carboxylases (VKGC) has revealed the presence of a novel domain, HTTM (for horizontally transferred transmembrane) in its N terminus. In contrast to most known domains, HTTM contains four transmembrane regions. Its occurrence in eukaryotes, bacteria and archaea is probably caused by horizontal gene transfer rather than by early evolution. The conservation of VKGC catalytic sites also indicates an enzymatic function for the other family members.
authors.affiliation: Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany. Joerg.Schultz@biozentrum.uni-wuerzburg.de
authors.forename: Jörg
authors.initials: J
authors.lastname: Schultz
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019735:Carbon-Carbon Ligases / Q000737:chemistry* / Q000235:genetics*; D022761:Gene Transfer, Horizontal; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
chemical_list: D019735:Carbon-Carbon Ligases; C020660:glutamyl carboxylase