title: Impact of cancer occurrence on health-related quality of life: a longitudinal pre-post assessment.
abstract: BACKGROUND
  Investigations focusing and implementing on the impact of cancer on health-related quality of life (HRQoL) by the way of a mean comparison between cancer patients and subjects from the general population, are scarce and usually cross-sectional. Longitudinal application of HRQoL instruments to a general, initially healthy population allows for change to be assessed as an event occurs, rather than afterwards. The objective of the present study was to investigate the impact of new cancer on HRQoL.
  
  
  METHODS
  The 36-item Short Form (SF-36) and 12-item General Health Questionnaire (GHQ-12) were applied to the French SU.VI.MAX cohort in 1996 and 1998. A controlled longitudinal study was used to determine the impact on HRQoL of newly diagnosed cancer: 84 patients with cancer that occurred between the 2 HRQoL measures were compared with 420 age- and sex-matched cancer-free controls.
  
  
  RESULTS
  Initial HRQoL level was similar in the two groups. A new cancer had a particularly marked effect on the SF-36 Physical functioning, Role-physical and General health dimensions (more than 6.6-point difference in change in HRQoL evolution on a 0-100 scale). The Bodily pain and Vitality dimensions were less severely affected (difference in change varying from 4.4 to 6.3 points), and there was no effect on either the GHQ-12 score or the SF-36 Mental health, Role-emotional and Social functioning dimensions.
  
  
  CONCLUSIONS
  The negative impact of cancer on the lives of patients was assessed in terms of HRQoL. The aspects most likely to be affected were those with a physical component, and general health perceptions. These results can thus help quantify the impact of a new cancer on HRQoL evolution and potentially facilitate early intervention by identifying the most affected HRQoL domains.
authors.affiliation: EA 3444 - Ecole de Santé Publique, Faculté de médecine, Université Henry Poincaré de Nancy, 9 avenue de la forêt de Haye, BP 184, 54500 Vandoeuvre Les Nancy, France. stephanie.boini@sante-pub.u-nancy.fr
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Boini
authors.forename: Serge
authors.initials: S
authors.lastname: Briançon
authors.forename: Francis
authors.initials: F
authors.lastname: Guillemin
authors.forename: Pilar
authors.initials: P
authors.lastname: Galan
authors.forename: Serge
authors.initials: S
authors.lastname: Hercberg
mesh_terms: D000328:Adult; D003863:Depression / Q000209:etiology; D019587:Dietary Supplements / Q000706:statistics & numerical data; D005221:Fatigue / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000008:administration & dosage; D015999:Multivariate Analysis; D009369:Neoplasms / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy; D017063:Outcome Assessment, Health Care / Q000379:methods*; D010146:Pain / Q000209:etiology; D011594:Psychometrics / Q000295:instrumentation*; D011788:Quality of Life; D018434:Sickness Impact Profile; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D008903:Minerals; D014815:Vitamins