title: Dose individualization in PharmDIS-e+.
abstract: Individualized dosage regimen calculations require knowledge on the pharmacokinetic and pharmacodynamic properties of the drug and the characteristics of the patient. A PK-PD-based dosage regimen is not easily and generally applicable, mainly because the combination of available PK parameters and therapeutic target levels may be inappropriate for the purpose of predicting a plausible dosage regimen. Within the project PharmDIS-e+, an alternative approach was chosen, and this "PK and standard dose"-based principle is well suited for computerized dosing advice. PharmDIS-e+ aims at the development of several applications for dosing regimen advice for general practitioners, hospital physicians and pharmacists.
authors.affiliation: Department of Pharmacokinetics and Drug Delivery, Groningen, The Netherlands. j.h.proost@farm.rug.nl
authors.forename: J H
authors.initials: JH
authors.lastname: Proost
authors.forename: N C
authors.initials: NC
authors.lastname: Punt
mesh_terms: D000368:Aged; D002648:Child; D004346:Drug Information Services / Q000458:organization & administration*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D010599:Pharmacokinetics; D010600:Pharmacology; D051437:Renal Insufficiency / Q000188:drug therapy / Q000378:metabolism
chemical_list: D004364:Pharmaceutical Preparations