How transcription factors regulate origins of DNA replication in eukaryotic cells.
Eukaryotic chromosomes contain a few thousand origins of DNA replication, which are activated in a temporal and spatial order during S phase. One parameter that is strongly implicated in determining the order of replication is transcription. This review focuses on the role of transcription factors in activating origins of replication in eukaryotic cells. Studies of viral and mitochondrial replication origins have revealed several mechanisms by which transcription factors activate origins, but it remains to be seen whether any of these are used to regulate cellular chromosome replication.
DePamphili
M L
ML
Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110, USA.