Interaction of GSTM1, GSTT1, and GSTP1 genotypes in determination of predisposition to atopic dermatitis.
The frequency of individual genotypes GSTM1, GSTT1, and GSTP1 and haplotypes was determined in patients with atopic dermatitis and healthy children. The actual frequency of some haplotypes was far below the theoretical value. Some haplotypes were associated with predisposition and resistance to atopic dermatitis.
Vavilin
V A
VA
Institute of Molecular Biology and Biophysics, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. drugsmet@cyber.ma.nsc.ru
Safronova
O G
OG
Lyapunova
A A
AA
Lyakhovich
V V
VV
Kaznacheeva
L F
LF
Manankin
N A
NA
Molokova
A V
AV
D000293:Adolescent; D000483:Alleles; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D006239:Haplotypes; D006801:Humans; D007223:Infant; D007527:Isoenzymes; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012426:Russia / Q000453:epidemiology
D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; D007527:Isoenzymes; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human