title: Comparison of patient-controlled epidural bolus administration of 0.1% ropivacaine and 0.1% levobupivacaine, both with 0.0002% fentanyl, for analgesia during labour.
abstract: The aim of the study was to compare the relative potencies and clinical characteristics of epidural ropivacaine and levobupivacaine in labour using patient-controlled epidural analgesia (PCEA). In a randomised double-blinded study, 60 ASA I or II primigravidae requesting epidural analgesia in early labour were allocated to receive either 0.1% ropivacaine with fentanyl 0.0002% or 0.1% levobupivacaine with 0.0002% fentanyl via a patient-controlled analgesia pump. Analgesia was established with 15 ml of study solution and maintained using 5-ml boluses of study solution with a 5-min lockout interval. There were no significant differences in onset time, duration and quality of analgesia, motor and sensory blockade, local anaesthetic consumption, mode of delivery, neonatal outcome or maternal satisfaction between the groups. We conclude that 0.1% ropivacaine with 0.0002% fentanyl and 0.1% levobupivacaine with 0.0002% fentanyl are clinically indistinguishable for labour analgesia and appear pharmacologically equipotent when using PCEA.
authors.affiliation: University Department of Anaesthesia, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, G31 2ER, UK. niall.purdie@utoronto.ca
authors.forename: N L
authors.initials: NL
authors.lastname: Purdie
authors.forename: E M
authors.initials: EM
authors.lastname: McGrady
mesh_terms: D000328:Adult; D000577:Amides; D015360:Analgesia, Epidural / Q000379:methods*; D016362:Analgesia, Obstetrical / Q000379:methods*; D016058:Analgesia, Patient-Controlled / Q000379:methods*; D019162:Anesthetics, Combined; D000779:Anesthetics, Local; D002045:Bupivacaine / Q000031:analogs & derivatives; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl; D006801:Humans; D000077554:Levobupivacaine; D017060:Patient Satisfaction; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D000077212:Ropivacaine
chemical_list: D000577:Amides; D019162:Anesthetics, Combined; D000779:Anesthetics, Local; D000077212:Ropivacaine; D000077554:Levobupivacaine; D005283:Fentanyl; D002045:Bupivacaine