title: Changes in anthropometry with testosterone therapy in a female with gender identity disorder.
abstract: A 31-year-old regularly menstruating Japanese female was referred to our outpatient clinic by a psychiatrist. She had been diagnosed as having gender identity disorder by detailed counseling and clinical intervention 3 years earlier. After obtaining fully informed written consent, we treated her with 125 mg of testosterone enanthate, intramuscularly, every 2 weeks for 4 months. Serum testosterone levels increased to the normal male value (from 28 to 432 ng/dL). Although menstrual cycle remained regular, her voice became lower after 4 months of therapy. Body weight, body mass index, and lean body mass increased, while body fat mass and percentage of body fat decreased. However, trunk-leg fat ratio did not change during the observation period. During testosterone therapy, a disproportionate increase in lean body mass and decrease in body fat mass are early onset events, while the shift toward upper body fat distribution may be a late onset event along with increase in BMD.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Kagoshima University, Sakuragaoka, Kagoshima, Japan.
authors.forename: Hideki
authors.initials: H
authors.lastname: Yamasaki
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Douchi
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Nagata
mesh_terms: D000328:Adult; D000886:Anthropometry; D001823:Body Composition / Q000187:drug effects; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D015519:Bone Density / Q000187:drug effects; D005260:Female; D005783:Gender Identity; D006801:Humans; D008597:Menstrual Cycle; D019968:Sexual and Gender Disorders / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D013739:Testosterone / Q000031:analogs & derivatives / Q000627:therapeutic use*; D014831:Voice / Q000187:drug effects
chemical_list: D013739:Testosterone; C004648:testosterone enanthate