[Study on the absorption, distribution and excretion of 3-chloro-1,2-propandiol in rats].
OBJECTIVE
To explore the absorption, distribution and excretion of 3-Chloro-1,2-propandiol (3-MCPD) in healthy male SD rats after oral administration.


METHODS
3-MCPD was administrated with a single oral dosage of 75 mg/kg BW to each rat. Samples of blood, tissues (including liver, kidney, brain and testicle) and excreta were then collected, and analyzed by the GC-MS method to determine 3-MCPD concentrations. The reported value is the mean value of three rats.


RESULTS
At 2 h after the administration, 3-MCPD concentrations in blood, testicle and kidney were (67.46 +/- 7.72), (78.37 +/- 5.15) and (56.21 +/- 3.64) microg/g, respectively. At 24 h, however, the corresponding values changed to (1.07 +/- 0.97) microg/g, (49.43 +/- 28.18) microg/g and (11.41 +/- 2.55) microg/g. During the 24-hour period, 9.74 +/- 3.05% of the given parent compound was excreted in urine, whereas 0.56 +/- 0.22% and 0.28 +/- 0.03% were excreted in feces and bile, respectively, which implies that kidney is a major organ for excretion 3-MCPD.


CONCLUSIONS
3-MCPD was quickly absorbed through the alimentary tract and quickly distributed into a number of tissues, and then accumulated in the target organs, especially in the testicle. The excretion of the parent compound was largely through the kidney. It was inferred that 3-MCPD was mainly metabolized in the liver.
Xiao
Ying
Y
Department of Nutrition and Food Hygiene, Peking University Health Science Center, Beijing 100083, China.
Zhou
Yuan
Y
Luo
Ren-cai
RC
Zhang
Zheng
Z
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000378:metabolism; D002629:Chemosterilants / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*; D016903:Drug Monitoring / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013737:Testis / Q000378:metabolism; D014018:Tissue Distribution; D000517:alpha-Chlorohydrin / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics*
D002629:Chemosterilants; D000517:alpha-Chlorohydrin