title: Prediagnostic human T lymphotropic virus type I provirus loads were highest in Jamaican children who developed seborrheic dermatitis and severe anemia.
abstract: In a recent clinical analysis of 308 Jamaican children, human T lymphotropic virus type I (HTLV-I) infection was found to be associated with significantly higher incidence rates of seborrheic dermatitis, eczema, and persistent hyperreflexia of the lower limbs and with nonsignificantly increased rates of severe anemia and abnormal lymphocytes. Results of examination of HTLV-I viral markers in the 28 HTLV-I-infected children provided virologic support for the epidemiologic associations of HTLV-I with seborrheic dermatitis and severe anemia in childhood.
authors.affiliation: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA. maloneyb@mail.nih.gov
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Maloney
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nagai
authors.forename: Michie
authors.initials: M
authors.lastname: Hisada
authors.forename: Samantha S
authors.initials: SS
authors.lastname: Soldan
authors.forename: P Bradley
authors.initials: PB
authors.lastname: Goebel
authors.forename: Mary
authors.initials: M
authors.lastname: Carrington
authors.forename: Takashi
authors.initials: T
authors.lastname: Sawada
authors.forename: Meghan B
authors.initials: MB
authors.lastname: Brennan
authors.forename: Beverley
authors.initials: B
authors.lastname: Cranston
authors.forename: Barrie
authors.initials: B
authors.lastname: Hanchard
authors.forename: Steven
authors.initials: S
authors.lastname: Jacobson
mesh_terms: D000740:Anemia / Q000453:epidemiology / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D012628:Dermatitis, Seborrheic / Q000453:epidemiology / Q000209:etiology*; D018450:Disease Progression; D015490:HTLV-I Infections / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D015994:Incidence; D007223:Infant; D007563:Jamaica / Q000453:epidemiology; D011533:Proviruses / Q000302:isolation & purification*; D012307:Risk Factors; D019562:Viral Load
chemical_list: D015415:Biomarkers