[The role of cell adhesion, multidrug resistance and cell proliferation in short-term recurrent cases with T1G3 superficial bladder cancer].
OBJECTIVE
To evaluate the roles of cell adhesion, multidrug resistance and cell proliferation in short-term recurrent cases with superficial bladder cancer, and the prognostic value of the three indexes.


METHODS
Immunohistochemical staining for E-cad, P-gp and Ki-67 was performed on the tumors of 100 patients with stage T0-T1 transitional cell carcinoma of the bladder who had been included in a retrospective research by follow-up.


RESULTS
E-cad and P-gp expression was positive in 51 (43.2%)and 17 (14.4%) of the tumors, respectively and mean proliferation index (PI) was 22.1%. The decrease in E-cad expression was accompanied with the increasing recurrent episodes (P < 0.05), while increase of P-gp expression and PI were accompanied with the increasing recurrence episodes (P < 0.05). There was significant difference according to E-cad, P-gp positivity and between T(1)G(3) patients and no-T(1)G(3) patients (P < 0.05). There was negative correlation of E-cad expression with P-gp expression and PI.


CONCLUSIONS
Minimum adhesion, strong drug resistance and maximum proliferation are the main factors that promote short-term recurrence of superficial bladder cancer and also the inherent reasons for easy recurrence and high malignancy of T(1)G(3) tumors. During this course, the three aspects may interact.
Zhu
Yu-yan
YY
Department of Urology, the First Clinical College, China Medical University, Shenyang 110001, China.
Kong
Chui-ze
CZ
Zeng
Yu
Y
Pang
Guo-you
GY
Yang
Chun-ming
CM
Sun
Zhi-xi
ZX
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis; D000328:Adult; D015820:Cadherins / Q000032:analysis; D002448:Cell Adhesion; D002455:Cell Division; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D015820:Cadherins; D019394:Ki-67 Antigen