title: Sealing percutaneous nephrolithotomy tracts with gelatin matrix hemostatic sealant: initial clinical use.
abstract: OBJECTIVE
  Tubeless percutaneous nephrolithotomy (PCNL) has been performed at several centers with good success. However, these cases have been carefully selected with regard to short duration and smaller stone burden to prevent complications associated with the loss of access to the collecting system. We describe the use of gelatin matrix hemostatic sealant (FloSeal Baxter Medical, Fremont, California) as an adjunct to tubeless percutaneous nephrolithotomy to help preclude bleeding complications.
  
  
  METHODS
  Two patients were treated with PCNL through a single nephrostomy tract. At the satisfactory conclusion of the cases the tract was occluded retrograde with an occlusion balloon catheter and gelatin matrix hemostatic sealant was injected down the nephrostomy tract. An indwelling stent and bladder catheter were placed following which all guidewires were removed and skin sutures were placed.
  
  
  RESULTS
  The operative times were 75 and 180 minutes, respectively. Both patients had stable postoperative hemoglobin and no evidence of bleeding or obstruction on postoperative computerized tomography.
  
  
  CONCLUSIONS
  Injection of gelatin matrix hemostatic sealant into the nephrostomy tract may be of value in preventing bleeding after PCNL. In this pilot experience it provided immediate and effective hemostasis.
authors.affiliation: Department of Urology, University of California, Irvine, USA.
authors.forename: David I
authors.initials: DI
authors.lastname: Lee
authors.forename: Carlos
authors.initials: C
authors.lastname: Uribe
authors.forename: Louis
authors.initials: L
authors.lastname: Eichel
authors.forename: Sepehr
authors.initials: S
authors.lastname: Khonsari
authors.forename: Jay
authors.initials: J
authors.lastname: Basillote
authors.forename: Hyung Keun
authors.initials: HK
authors.lastname: Park
authors.forename: Ching Chia
authors.initials: CC
authors.lastname: Li
authors.forename: Elspeth M
authors.initials: EM
authors.lastname: McDougall
authors.forename: Ralph V
authors.initials: RV
authors.lastname: Clayman
mesh_terms: D005260:Female; D005780:Gelatin; D006489:Hemostatic Techniques; D006801:Humans; D007669:Kidney Calculi / Q000601:surgery*; D008875:Middle Aged; D009403:Nephrostomy, Percutaneous / Q000379:methods*; D014014:Tissue Adhesives
chemical_list: D014014:Tissue Adhesives; D005780:Gelatin