title: [Malignant neoplasia and kidney transplantation. Retrospective analysis of data on the population having kidney transplantation with de novo neoplasia in the setting of the AIRT].
abstract: BACKGROUND
  In transplanted patients undergoing immunossuppressive therapy the incidence of malignant neoplasia is 3-4 times higher than in the general population. Aim of the present study was to evaluate the prevalence of different tumours and the links between modulation of immunosuppressive therapy and patient and graft survival.
  
  
  METHODS
  We evaluated 2029 kidney-transplanted patients from four Transplant Centres (Bari, Bologna, Modena, Novara) belonging to the Associazione InterRegionale Trapianti (AIRT).
  
  
  RESULTS
  The incidence of neoplastic disease after transplantation was 3.9% in our population with a median time between transplantation and clinical onset of 23 months. We demonstrated a significant difference in the geographical distribution of different tumours. We did not observe any correlation with specific immunosuppressive drugs. Finally, dramatic reduction of the immunosuppression levels did not modify either the patients' or the graft's survival.
  
  
  CONCLUSIONS
  Several factors can influence the post-transplant onset of neoplastic diseases with immunosuppressive therapy playing a pivotal role. The implementation of a National Registry would be the first step in an attempt to optimise immunosuppression in this particular group of patient's.
authors.affiliation: Divisione di Nefrologia, Dipartimento di Emergenza e Trapianti d'Organo, Universita' degli Studi di Bari - Policlinico, Bari, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Stallone
authors.forename: B
authors.initials: B
authors.lastname: Infante
authors.forename: A
authors.initials: A
authors.lastname: Schena
authors.forename: G
authors.initials: G
authors.lastname: Grandaliano
authors.forename: S
authors.initials: S
authors.lastname: Di Paolo
authors.forename: M P
authors.initials: MP
authors.lastname: Scolari
authors.forename: S
authors.initials: S
authors.lastname: Stefoni
authors.forename: M
authors.initials: M
authors.lastname: Zanazzi
authors.forename: M
authors.initials: M
authors.lastname: Salvadori
authors.forename: A M
authors.initials: AM
authors.lastname: Savazzi
authors.forename: A
authors.initials: A
authors.lastname: Albertazzi
authors.forename: C
authors.initials: C
authors.lastname: Cornella
authors.forename: E
authors.initials: E
authors.lastname: Turello
authors.forename: F P
authors.initials: FP
authors.lastname: Schena
mesh_terms: D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects*; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence; D012189:Retrospective Studies