Structure and pharmacology of swelling-sensitive chloride channels, I(Cl,swell).
Since several years, the interest for chloride channels and more particularly for the enigmatic swelling-activated chloride channel (I(Cl,swell)) is increasing. Despite its well-characterized electrophysiological properties, the I(Cl,swell) structure and pharmacology are not totally elucidated. These channels are involved in a variety of cell functions, such as cardiac rhythm, cell proliferation and differentiation, cell volume regulation and cell death through apoptosis. This review will consider different aspects regarding structure, electrophysiological properties, pharmacology, modulation and functions of these swelling-activated chloride channels.
d'Anglemont de Tassigny
Alexandra
A
Laboratoire de Pharmacologie, INSERM E00.01, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France.
Souktani
Rachid
R
Ghaleh
Bijan
B
Henry
Patrick
P
Berdeaux
Alain
A
D000818:Animals; D048429:Cell Size / Q000187:drug effects* / Q000502:physiology*; D018118:Chloride Channels / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects* / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology
D018118:Chloride Channels