Comparative mapping of rat Iddm4 to segments on HSA7 and MMU6.
Iddm4 is one of several susceptibility genes that have been identified in the BB rat model of type 1 diabetes. The BB rat allele of this gene confers dominant predisposition to diabetes induction by immune perturbation in both the diabetes-prone and the diabetes-resistant substrains, whereas the Wistar Furth (WF) allele confers resistance. We have positioned the gene in a 2.8-cM region on rat Chromosome (Chr) 4, proximal to Lyp/Ian4l1. We have produced a radiation hybrid map of the Iddm4-region that includes a number of rat genes with their mouse and human orthologs. We present a comparative map of the rat Iddm4 region in rat, human, and mouse, assigning the gene to a 6.3-Mb segment between PTN and ZYX at 7q32 in the human genome, and to a 5.7-Mb segment between Ptn and Zyx in the mouse genome.
Hornum
Lars
L
Hagedorn Research Institute, Niels Steensens Vej 6, DK-2820 Gentofte, Denmark.
DeScipio
Cheryl
C
Markholst
Helle
H
Troutman
Scott A
SA
Novak
Stephen
S
Leif
Jean
J
Greiner
Dale
D
Mordes
John P
JP
Blankenhorn
Elizabeth P
EP
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002875:Chromosomes / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000473:pathology; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D016678:Genome; D006801:Humans; D008126:Lod Score; D051379:Mice; D018895:Microsatellite Repeats; D021101:Radiation Hybrid Mapping; D051381:Rats; D011913:Rats, Inbred BB; D011920:Rats, Inbred WF
D002352:Carrier Proteins; D005819:Genetic Markers