[Effects of different dosages of cyclosporine A on the semen parameters of renal transplant patients].
OBJECTIVE
To evaluate the effects of different dosages of cyclosporine A (CsA) on the main semen parameters and sperm morphology of the patients after renal transplantation.


METHODS
The semen of 18 patients after renal transplantation treated with different dosages of CsA was analyzed and the semen parameters and sperm morphology were compared with those of 12 normal volunteers.


RESULTS
There was not significant difference between the main parameters of the patients treated with 1.5-3.0 mg.Kg-1.d-1 of CsA and 3.1-5.5 mg.Kg-1.d-1 of CsA and those of the volunteers (P > 0.05), but the rate of normal sperm morphology was significantly different between the two groups(P < 0.05).


CONCLUSIONS
Different therapeutic dosages of CsA did not have any effect on most of the semen parameters of the patients after renal transplantation, but did affect the sperm morphology.
Xu
Long-Gen
LG
Renal Transplantation Center, Hospital 117 of PLA, Hangzhou, Zhejiang 310014, China.
Xu
Hui-Ming
HM
Zhang
Jun-Rong
JR
Song
Qi-Zhe
QZ
Qi
Xiao-Ping
XP
Wang
Xin-Hong
XH
D000328:Adult; D016572:Cyclosporine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016030:Kidney Transplantation; D008297:Male; D012661:Semen / Q000187:drug effects; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*
D007166:Immunosuppressive Agents; D016572:Cyclosporine