title: [Comparison of thrombolysis and anticoagulation in pulmonary thromboembolism: a meta-analysis].
abstract: OBJECTIVE
  To pool the data of studies about thrombolysis in pulmonary thromboembolism (PTE) and evaluate the efficacy and safety of thrombolysis.
  
  
  METHODS
  The randomized clinical trials (RCTs) that compared the efficacy or safety of thrombolysis and anticoagulation in massive or submassive PTE were chosen from MEDLINE disks from 1966 to May of 2003 and CBM disks from 1978 to May of 2003. A meta-analysis was employed to evaluate the results of the two therapies.
  
  
  RESULTS
  Twelve RCTs including 884 cases were analyzed. Compared with anticoagulation, the total OR of mortality and recurrence of patients with PTE treated with thrombolysis were 0.975 (95% CI 0.504 - 1.886) and 0.653 (95% CI 0.378 - 1.127) respectively, non-significant difference (P > 0.05). The total OR of bleeding in thrombolysis was 2.461 (95% CI 1.636 - 3.702, P < 0.01).
  
  
  CONCLUSIONS
  Compared with anticoagulation, thrombolysis cannot reduce the mortality or recurrence of PTE. Thrombolysis increases the risk of complication of bleeding.
authors.affiliation: Beijing Chaoyang Hospital-Beijing Institute of Respiratory Medicine, Capital University of Medical Sciences, Beijing 100020, China.
authors.forename: Zhi-qiang
authors.initials: ZQ
authors.lastname: Qin
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D011655:Pulmonary Embolism / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D015912:Thrombolytic Therapy / Q000009:adverse effects
chemical_list: D000925:Anticoagulants