Fibrillary glomerulonephritis associated with essential thrombocytosis.
A 68-year-old man with a 30-year history of essential thrombocytosis developed nephrotic syndrome. Renal biopsy showed massive deposits of Congo red-negative periodic acid Schiff (PAS)-positive substance in the mesangium and capillary wall that was positive for IgG. Electron microscopic examination revealed 10- to 20-nm fibrils in the deposits, and there was no other organ involvement; thus, we diagnosed fibrillary glomerulonephritis. This is the first report of a case of fibrillary glomerulonephritis associated with essential thrombocytosis.
Asaba
Kensuke
K
Division of Nephrology and Endocrinology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Tojo
Akihiro
A
Onozato
Maristela Lika
ML
Mimura
Natsuko
N
Kido
Makiko
M
Goto
Atsuo
A
Endo
Hisako
H
Fujita
Toshiro
T
D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D005921:Glomerulonephritis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D008854:Microscopy, Electron; D009404:Nephrotic Syndrome / Q000150:complications / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D013922:Thrombocytosis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*
D000893:Anti-Inflammatory Agents; D018906:Antineoplastic Agents, Alkylating; D011239:Prednisolone; D008558:Melphalan