Mammalian cell cycles without cyclin E-CDK2.
The family of mammalian E-type cyclins is composed of two proteins, termed cyclin E1 and E2. These two cyclins are widely expressed in proliferating cells. E-cyclins bind and activate cyclin dependent kinase CDK2. Cyclin E-CDK2 complexes were believed to play critical function in driving cell cycle progression of normal, nontransformed cells and of cancer cells. Several recent reports challenge this notion.
Yu
Qunyan
Q
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.
Sicinski
Piotr
P
D000818:Animals; D042846:CDC2-CDC28 Kinases / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle; D019927:Cyclin E / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D051357:Cyclin-Dependent Kinase 2; D004622:Embryo, Mammalian / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D017353:Gene Deletion; D051379:Mice
D019927:Cyclin E; D042846:CDC2-CDC28 Kinases; C495893:Cdk2 protein, mouse; D051357:Cyclin-Dependent Kinase 2