[Low density lipoprotein apheresis].
Increased blood cholesterol concentration is one of the main factors in ischemic heart disease, development of which is determined by atherosclerotic changes in coronary vessels. Diet and treatment with 3-hydroxi-3-metilglutaril coenzyme A (HMG-CoA) reductase inhibitors helps to reduce low density lipoprotein cholesterol (LDL-Ch) blood concentration up to recommended level of 3.0 mmol/l in most patients but in some patients particularly with familial dyslipidemias cholesterol concentration remains increased even after treatment with maximal doses of lipid-regulating agents or their combinations. The most frequently used mechanical methods of cholesterol removal from blood include the procedures of extracorporeal apheresis. Low density lipoprotein (LDL) apheresis not only significantly reduces the blood concentrations of total cholesterol (TCh), and LDL-Ch, lipoprotein (a) (Lp(a) and fibrinogen but also stops the progression of atherosclerosis in coronary vessels.
Zaliūnas
Remigijus
R
Clinic of Cardiology, Kaunas University of Medicine, Eiveniu 2, 3007 Kaunas, Lithuania.
Slapikas
Rimvydas
R
Gustiene
Olivija
O
Siurkus
Jonas
J
Vaitkus
Eduardas
E
D000328:Adult; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D001161:Arteriosclerosis / Q000517:prevention & control*; D001779:Blood Coagulation Factors; D001781:Blood Component Removal / Q000295:instrumentation / Q000379:methods; D008078:Cholesterol, LDL / Q000097:blood / Q000302:isolation & purification*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000517:prevention & control; D023921:Coronary Stenosis / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000628:therapy*
D000924:Anticholesteremic Agents; D001779:Blood Coagulation Factors; D008078:Cholesterol, LDL