title: Exo selective enantioselective nitrone cycloadditions.
abstract: We have developed a novel method for accessing exo adducts with high enantioselectivity in nitrone cycloadditions to enoates. Pyrazolidinones proved to be effective achiral templates in the cycloadditions, providing exo adducts typically in >15:1 selectivity and 90-98% ee. The use of Lewis acids that form square planar complexes, such as copper triflate, was important for obtaining high exo selectivity.
authors.affiliation: Department of Chemistry, North Dakota State University, Fargo, North Dakota 58105, USA. mukund.sibi@ndsu.nodak.edu
authors.forename: Mukund P
authors.initials: MP
authors.lastname: Sibi
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Ma
authors.forename: Craig P
authors.initials: CP
authors.lastname: Jasperse