Glucocorticoid effects on object recognition memory require training-associated emotional arousal.
Considerable evidence implicates glucocorticoid hormones in the regulation of memory consolidation and memory retrieval. The present experiments investigated whether the influence of these hormones on memory depends on the level of emotional arousal induced by the training experience. We investigated this issue in male Sprague-Dawley rats by examining the effects of immediate posttraining systemic injections of the glucocorticoid corticosterone on object recognition memory under two conditions that differed in their training-associated emotional arousal. In rats that were not previously habituated to the experimental context, corticosterone (0.3, 1.0, or 3.0 mg/kg, s.c.) administered immediately after a 3-min training trial enhanced 24-hr retention performance in an inverted-U shaped dose-response relationship. In contrast, corticosterone did not affect 24-hr retention of rats that received extensive prior habituation to the experimental context and, thus, had decreased novelty-induced emotional arousal during training. Additionally, immediate posttraining administration of corticosterone to nonhabituated rats, in doses that enhanced 24-hr retention, impaired object recognition performance at a 1-hr retention interval whereas corticosterone administered after training to well-habituated rats did not impair 1-hr retention. Thus, the present findings suggest that training-induced emotional arousal may be essential for glucocorticoid effects on object recognition memory.
Okuda
Shoki
S
Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA. okudas@uci.edu
Roozendaal
Benno
B
McGaugh
James L
JL
D000818:Animals; D001143:Arousal / Q000502:physiology*; D003213:Conditioning, Psychological / Q000502:physiology; D003345:Corticosterone / Q000494:pharmacology*; D004644:Emotions / Q000502:physiology; D005938:Glucocorticoids / Q000502:physiology; D006185:Habituation, Psychophysiologic / Q000502:physiology; D007858:Learning / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D005938:Glucocorticoids; D003345:Corticosterone