title: [Using chemical methods to crosslink xenogeneic heart valves: the progress of bioprosthetic heart valves].
abstract: Glutaraldehyde clinically is the most commonly accepted crosslinking reagent for bioprosthetic valves preparation. Glutaraldehyde-treated tissue is stable against chemical and enzymatic degradation; however, its calcification and cytotoxicity are severe. Dye-mediated photooxidation is an alternative tissue preservation method that oxidizes the protein with visible light in the presence of a suitable photosensitizer. This article reviews chemical mechanism, research progress, clinical applications future development of these two methods.
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Lin
authors.forename: Ying-wu
authors.initials: YW
authors.lastname: Tang
authors.forename: Rui
authors.initials: R
authors.lastname: Chang
authors.forename: Jian-ye
authors.initials: JY
authors.lastname: Zhou
authors.forename: Jing-wei
authors.initials: JW
authors.lastname: Cui
authors.forename: Sheng-shou
authors.initials: SS
authors.lastname: Hu
authors.forename: Fu-shi
authors.initials: FS
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D002114:Calcinosis; D003432:Cross-Linking Reagents; D005976:Glutaral; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D010777:Photochemistry
chemical_list: D003432:Cross-Linking Reagents; D005976:Glutaral