In silico prediction of the structure of membrane proteins: is it feasible?
In the 'omic' era, hundreds of genomes are available for protein sequence analysis, and some 30 per cent of all sequences are of membrane proteins. Unlike globular proteins, a 3D model for membrane proteins can hardly be computed starting from the sequence. Why is this so? What can we really compute and with what reliability? These and other matters are outlined.
Casadio
Rita
R
Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna, Via Irnerio 42, 40126 Bologna, Italy. casadio@alma.unibo.it
Fariselli
Piero
P
Martelli
Pier Luigi
PL
D019295:Computational Biology; D008565:Membrane Proteins / Q000737:chemistry*; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D020539:Sequence Analysis, Protein
D008565:Membrane Proteins