title: Gabexate mesilate (FOY) inhibition of amylase and phospholipase A(2) activity in sow pancreatic juice.
abstract: We designed this study in sows to investigate the enzyme inhibitory action of gabexate mesylate (GM) directly in the pancreatic juice. We studied 16 sows, each weighing about 130 kg. The pancreatic duct was identified and cannulated to collect the pancreatic juice. Sows in the treated group received intravenous GM infusion at a dose of 1000 mg over 24 h. Control sows underwent the same sampling schedule while receiving physiological solution. GM inhibited the two pancreatic enzymes amylase and phospholipase A(2) (PA(2)) in pancreatic juice. Thus, the enzyme inhibition in the pancreatic gland itself and the central role of (PA(2)) inhibition in enzyme cascade responsible for activating other proteases confirm the therapeutic use of GM in acute pancreatitis.
authors.affiliation: Dipartimento di Chirurgia "Pietro Valdoni", Universitá di Roma "La Sapienza", Rome, Italy. roberto.caronna@uniroma1.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Caronna
authors.forename: Diana
authors.initials: D
authors.lastname: Loretta
authors.forename: Paolo
authors.initials: P
authors.lastname: Campedelli
authors.forename: Stefania
authors.initials: S
authors.lastname: Catinelli
authors.forename: Italo
authors.initials: I
authors.lastname: Nofroni
authors.forename: Simone
authors.initials: S
authors.lastname: Sibio
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sinibaldi
authors.forename: Piero
authors.initials: P
authors.lastname: Chirletti
mesh_terms: D000208:Acute Disease; D000681:Amylases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D005260:Female; D016670:Gabexate / Q000494:pharmacology*; D010189:Pancreatic Juice / Q000187:drug effects / Q000201:enzymology*; D010195:Pancreatitis / Q000188:drug therapy / Q000201:enzymology; D010741:Phospholipases A / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology*; D034421:Sus scrofa
chemical_list: D015842:Serine Proteinase Inhibitors; D016670:Gabexate; D010741:Phospholipases A; D000681:Amylases