Genomics in obstetrics and gynaecology.
With the Human Genome Project complete, and microarray technology progressing rapidly, the study of whole genomes has become a reality. The emerging field of genomics is full of promise, has become a cornerstone of commercial drug development, and looks certain to make a major contribution to clinical practice in the future. There is an increasing number of genomic studies concerned with obstetric and gynaecological conditions. Despite this, clinicians in their busy practices often lack a basic understanding of genomics and the tools involved in generating genome-based information. In the present review, we aim to provide the clinician with a basic overview of genomics--what it is, what tools it uses, and how it may benefit our patients. The existing published reports on genomic studies in the reproductive field is reviewed.
Weston
Gareth C
GC
Department of Obstetrics and Gynaecology, Monash Medical Centre, Monash University, Victoria, Australia. gareth.weston@med.monash.edu.au
Ponnampalam
Anna
A
Vollenhoven
Beverley J
BJ
Healy
David L
DL
Rogers
Peter A W
PA
D016172:DNA Fingerprinting; D005260:Female; D005786:Gene Expression Regulation; D005831:Genital Diseases, Female / Q000235:genetics*; D023281:Genomics; D006176:Gynecology; D016045:Human Genome Project; D006801:Humans; D009774:Obstetrics; D020411:Oligonucleotide Array Sequence Analysis