title: There's a problem in the furnace.
abstract: A long-sought-after mutation in the manganese superoxide dismutase gene MnSOD has been isolated in Drosophila melanogaster. The MnSOD null mutation is recessive lethal, with death occurring just after eclosion. In this Perspective, I discuss these results and related work in mice within the context of the oxidative damage theory of aging.
authors.affiliation: Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA. jtower@usc.edu
authors.forename: John
authors.initials: J
authors.lastname: Tower
mesh_terms: D000375:Aging / Q000235:genetics; D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics*; D008928:Mitochondria / Q000201:enzymology / Q000235:genetics; D009154:Mutation; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000235:genetics*
chemical_list: D029721:Drosophila Proteins; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase