title: Molecular regulation of cardiac chamber-specific gene expression.
abstract: This review focuses on recent studies investigating the genetic regulatory mechanisms leading to formation of morphologically, functionally, and molecularly distinct cardiac chambers. The regulation of four representative chamber-specific genes that have been studied in detail is reviewed. These genes include the atrial-specific genes, myosin light chain-2a (MLC2a), slow myosin heavy chain-3 (slow MyHC3), and atrial natriuretic factor (ANF) and the ventricular specific gene, myosin light chain-2v (MLC2v). Comparison of these promoters reveals some generalizations about the regulatory mechanisms involved in chamber-specific gene expression but, equally, indicates the large gaps in the knowledge concerning this intriguing genetic program.
authors.affiliation: Department of Cell Biology and Anatomy, University of Arizona Health Sciences Center, 1501 N. Campbell Avenue, Tucson, AZ 85724-5044, USA.
authors.forename: Eric M
authors.initials: EM
authors.lastname: Small
authors.forename: Paul A
authors.initials: PA
authors.lastname: Krieg
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics*; D009202:Cardiomyopathies / Q000235:genetics*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology*; D006801:Humans; D008297:Male; D008967:Molecular Biology; D018995:Myosin Heavy Chains / Q000235:genetics*; D018994:Myosin Light Chains / Q000235:genetics*; D012680:Sensitivity and Specificity
chemical_list: D018994:Myosin Light Chains; D009320:Atrial Natriuretic Factor; D018995:Myosin Heavy Chains