Tubby proteins: the plot thickens.
The tubby mouse, which shows late-onset obesity and neurosensory deficits, arises from a mutation in the Tub gene. Tub shares homology with the genes for tubby-like proteins Tulp1, Tulp2 and Tulp3. Ablation of Tub, Tulp1 or Tulp3 causes disease phenotypes that are indicative of their importance in nervous-system function and development. Despite this importance, the biochemical functions of tubby-like proteins are only now beginning to be understood. At present, data indicate that tubby-like proteins might function as heterotrimeric-G-protein-responsive intracellular signalling factors, although an array of data also implicates them in other processes.
Carroll
Kilpatrick
K
Department of Biochemistry and Molecular Biophysics, Columbia University, 701 West 168th Street, Room 712, New York, New York 10032, USA.
Gomez
Carlos
C
Shapiro
Lawrence
L
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D005314:Embryonic and Fetal Development / Q000235:genetics; D005136:Eye Proteins; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D009422:Nervous System Diseases / Q000235:genetics; D009765:Obesity / Q000235:genetics*; D017354:Point Mutation; D011506:Proteins / Q000737:chemistry / Q000235:genetics*
D048868:Adaptor Proteins, Signal Transducing; D005136:Eye Proteins; D011506:Proteins; C098988:Tub protein, mouse; C491353:Tulp1 protein, mouse