Regulatory T cells: potential in organ transplantation.
Active regulation or suppression of donor reactive cells is emerging as a key mechanism for inducing and maintaining unresponsiveness to donor alloantigens. Accumulating evidence suggests that a balance between immunoregulation and deletion of donor alloantigen reactive T cells can provide effective control of immune responsiveness after organ or cell transplantation. In many settings, immunoregulatory activity is enriched in CD4+ T cells that express high levels of CD25, and common mechanisms appear to be responsible for the activity of regulatory T cells in both transplantation and the control of reactivity to self-antigens.
Wood
Kathryn J
KJ
Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom. kathryn.wood@nds.ox.ac.uk.
Luo
Shiqiao
S
Akl
Ahmed
A
D016207:Cytokines / Q000502:physiology; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D016377:Organ Transplantation; D013601:T-Lymphocytes / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000502:physiology; D023001:Transplantation Tolerance
D016207:Cytokines; D007519:Isoantigens