Relationship between behavioral selection and primary and secondary immune response in wild gray rats.
The main characteristics of primary and secondary immune response (number of antibody producing cells and the amount of produced antibodies) are reduced in rats selected by elimination of aggressive behavior in comparison with animals selected by stimulation of this behavior. In parallel, the reaction of the pituitary-adrenal system during immune response was modified in these rats. Presumably, the differences in immune reactions of rats selected by contrast behavior are determined by changes in reactivity of the pituitary-adrenal system to stress and immune stimulation during selection.
Os'kina
I N
IN
Institute of Cytology and Genetics, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. oskina@bionet.nsc.ru
Shikhevich
S G
SG
Gulevich
R G
RG
D000374:Aggression / Q000502:physiology; D000818:Animals; D000917:Antibody Formation / Q000502:physiology*; D000941:Antigens / Q000276:immunology*; D001522:Behavior, Animal / Q000502:physiology*; D003345:Corticosterone / Q000097:blood / Q000502:physiology; D008297:Male; D010913:Pituitary-Adrenal System / Q000502:physiology; D051381:Rats; D012641:Selection, Genetic; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013315:Stress, Psychological / Q000276:immunology / Q000503:physiopathology*; D013997:Time Factors
D000941:Antigens; D003345:Corticosterone