title: Manifestations of gastroesophageal reflux and response to omeprazole therapy in patients with chronic posterior laryngitis: an evaluation based on clinical practice.
abstract: Our aims were to describe clinical characteristics of patients with chronic posterior laryngitis and to predict the response to omeprazole therapy. Ninety-one patients with posterior laryngitis were evaluated by a questionnaire, esophageal manometry and pH recording, and endoscopy. Patients were treated with omeprazole, 20 mg twice daily for 3 months. Therapy was continued another 3 months if necessary. Clinical manifestations of reflux occurred in 84 (92%) patients, abnormal acid reflux in 53 (65%) cases, and esophagitis in 6 of 50 (12%). After 3 months of therapy significant improvement occurred in 30 of 70 patients (41%). Continuing therapy for 3 more months increased the response to 65% (45 of 69 cases). Response to therapy was associated with lower age and lower duration of laryngeal symptoms, but a consistent prediction of the response could not be made. In conclusion, patients with posterior laryngitis frequently present with manifestations of gastroesophageal reflux. Response to therapy can not be predicted with certainty.
authors.affiliation: Gastroenterology Unit, Hospital La Fe, Valencia, Spain. garrigues_vic@gva.es
authors.forename: Vicente
authors.initials: V
authors.lastname: Garrigues
authors.forename: Lirios
authors.initials: L
authors.lastname: Gisbert
authors.forename: Guillermo
authors.initials: G
authors.lastname: Bastida
authors.forename: Vicente
authors.initials: V
authors.lastname: Ortiz
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Bau
authors.forename: Pilar
authors.initials: P
authors.lastname: Nos
authors.forename: Julio
authors.initials: J
authors.lastname: Ponce
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D005764:Gastroesophageal Reflux / Q000150:complications*; D006801:Humans; D007827:Laryngitis / Q000188:drug therapy* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use*; D010818:Practice Patterns, Physicians'; D011237:Predictive Value of Tests; D016896:Treatment Outcome
chemical_list: D000897:Anti-Ulcer Agents; D009853:Omeprazole