Reduction of the prenatal hypoxic-ischemic brain edema with noscapine.
Cytotoxic free radicals and release of several neurotransmitters such as bradykinin contribute to the pathogenesis of hypoxic-ischemic brain damage. We have studied the efficacy of noscapine, an opium alkaloid and a bradykinin antagonist, in reducing post-hypoxic-ischemic damage in developing brain of 7-d-old rat pups. Hypoxic-ischemic injury to the right cerebral hemisphere was produced by legation of the right common carotid artery followed by 3 h of hypoxia with 8% oxygen. Thirty to 45 min before hypoxia the rat pups received noscapine (dose = 0.5-2 mg/kg) or saline. Pups were scarified at 24 h post recovery for the assessment of cerebral damage by histological methods. Our results showed that noscapine was an effective agent in reducing the extent of brain injury after hypoxic-ischemic insult to neonatal rats. Therefore, it is concluded that noscapine may be a useful drug in the managements of patients after stroke.
Mahmoudian
M
M
Razi Institute for Drug Research, Iran University of Medical Sciences, Tehran, Iran.
Siadatpour
Zahra
Z
Ziai
S A
SA
Mehrpour
M
M
Benaissa
Faouzya
F
Nobakht
M
M
D000818:Animals; D000996:Antitussive Agents / Q000494:pharmacology*; D001479:Basal Ganglia / Q000473:pathology; D001929:Brain Edema / Q000188:drug therapy* / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D005333:Fetus / Q000187:drug effects; D020925:Hypoxia-Ischemia, Brain / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009665:Noscapine / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats
D000996:Antitussive Agents; D009665:Noscapine