Insulin stimulation of GLUT-4 translocation: a model for regulated recycling.
Insulin stimulates glucose transport in muscle and fat cells by causing the redistribution of a facilitative glucose transporter, GLUT-4, from an intracellular compartment to the cell surface. But what is this intracellular GLUT-4 compartment? It may be a specialized compartment, perhaps analogous to synaptic vesicles, or may simply be part of the endosomal system. Other constituents of this compartment might be regulators of GLUT-4 movement to the cell surface, and their identification should make it possible to find the link between the insulin signal transduction pathway and GLUT-4 translocation.
James
D E
DE
Centre for Molecular Biology and Biotechnology, University of Queensland, St Lucia, Brisbane 4072, Australia.
Piper
R C
RC
Slot
J W
JW