[Mathematical model of epidermal growth factor receptor-mediated lipid phosphatidylinositol(4,5)-bisphosphate hydrolyzation by phospholipase C-gamma1 activity].
OBJECTIVE
To investigate the dynamic characteristics of lipid phosphatidylinositol (4,5)-bisphosphate (PIP(2)) in plasma membrane hydrolyzed by phospholipase C-gamma1 in epidermal growth factor receptor(EGFR)-mediated signal pathway.


METHODS
A mathematical model based on the law of mass action was established with differential equations to simulate metabolizable pathway of PIP(2).


RESULTS
Differential equations of the key product concentration during hydrolysis of PIP(2) were formulated, and the effects of the parameters on these hydrolyzed products analyzed.


CONCLUSIONS
This mathematical model provides foundation for further investigation of the dynamic changes of biological characteristics and the relations between the key product concentrations in PIP2 hydrolysis.
Su
Yong-chun
YC
Teaching and Research Section of Medical Physics, Department of Medical Engineering, First Military Medical University, Guangzhou 510515, China. suyc@fimmu.com
Deng
Fan
F
Lu
Di
D
Bai
Xiao-chun
XC
Tan
Xiao-dan
XD
Dong
Ai-rong
AR
Luo
Shen-qiu
SQ
Deng
Qin-kai
QK
D066246:ErbB Receptors / Q000502:physiology*; D006868:Hydrolysis; D008962:Models, Theoretical; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism*; D051966:Phospholipase C gamma; D010738:Type C Phospholipases / Q000502:physiology*
D019269:Phosphatidylinositol 4,5-Diphosphate; D066246:ErbB Receptors; D010738:Type C Phospholipases; D051966:Phospholipase C gamma