[Toll type receptors: molecular bases of the relationship between innate and adaptation responses of the immune system].
Microbes have on their surface molecular patterns that are common among a broad range of pathogens. These patterns are recognized by a wide variety of cellular receptors, the most important of which are a family of transmembrane proteins termed "Toll-like receptors" (TLR). TLRs are pattern-recognition receptors that have key roles in detecting pathogens and initiating inflammatory responses. The receptor of Gram negative bacterial LPS, TLR4, is the best characterized member of the TLR family. So far, ten mammalian toll-like receptors (TLR1-TLR10) have been identified. Recent studies revealed that the TLR signaling pathway is a critical mediator of sepsis. An understanding of TLRs and their signaling pathway will reveal a therapeutic target in sepsis and other immune mediated diseases.
Moreno
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Servicio de Inmunología, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra.
Sánchez-Ibarrola
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D000818:Animals; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000276:immunology; D006801:Humans; D007109:Immunity / Q000502:physiology*; D008322:Mammals / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology*; D051194:Toll-Like Receptor 1; D051201:Toll-Like Receptor 10; D051197:Toll-Like Receptor 4; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors
D029721:Drosophila Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; C495345:TLR4 protein, human; D051194:Toll-Like Receptor 1; D051201:Toll-Like Receptor 10; D051197:Toll-Like Receptor 4; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors; C495341:tehao protein, Drosophila