Nicotine diminishes anticonvulsant activity of antiepileptic drugs in mice.
Nicotine administered acutely at subconvulsive dose of 4 mg/kg, significantly decreased the protective activity of valproate, carbamazepine, diphenylhydantoin, phenobarbital, topiramate and lamotrigine against maximal electroshock-induced tonic convulsions in mice. The obtained data may suggest that interaction between nicotine and antiepileptic drugs should be carefully considered as a cause of the therapeutic failure in epileptic patients.
Czuczwar
Mirosław
M
Department of Pharmacology and Toxicology, Medical University, Jaczewskiego 8, PL 20-090 Lublin, Poland.
Kiś
Jacek
J
Czuczwar
Piotr
P
Wielosz
Marian
M
Turski
Waldemar
W
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000493:pharmacokinetics; D002220:Carbamazepine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004597:Electroshock; D005632:Fructose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D006801:Humans; D007274:Injections, Intraperitoneal; D000077213:Lamotrigine; D051379:Mice; D009538:Nicotine / Q000008:administration & dosage* / Q000009:adverse effects* / Q000493:pharmacokinetics; D010634:Phenobarbital / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D010672:Phenytoin / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control; D000077236:Topiramate; D014227:Triazines / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics; D014635:Valproic Acid / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000493:pharmacokinetics
D000927:Anticonvulsants; D014227:Triazines; D000077236:Topiramate; D005632:Fructose; D002220:Carbamazepine; D014635:Valproic Acid; D010672:Phenytoin; D009538:Nicotine; D000077213:Lamotrigine; D010634:Phenobarbital