HLA-G modulates immune responses by diverse receptor interactions.
HLA-G regulates immune responses as it binds different receptors expressed on natural killer (NK) cells, T cells and myeloid cells. HLA-G1 can inhibit NK- and T-cell-mediated lysis of target cells by its interaction with the inhibitory receptors ILT2 and ILT4. Engaging KIR2DL4 triggers different reactions depending on the activation state of the effector cells. The indirect recognition of HLA-G as peptide presented by HLA-E and recognized by the CD94/NKG2 receptor family might further power the battle between the immune system and tumor cells. Secreted HLA-G5 can also bind CD8 and induces Fas/Fas ligand-mediated apoptosis in activated CD8+ lymphocytes.
Hofmeister
Valeska
V
Department Biologie II der Ludwig-Maximilians-Universität München, Anthropologie und Humangenetik, Richard-Wagner Str. 10/I, D-80333 Munich, Germany.
Weiss
Elisabeth H
EH
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D017209:Apoptosis; D001665:Binding Sites; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D006680:HLA Antigens / Q000378:metabolism* / Q000502:physiology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000378:metabolism* / Q000502:physiology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology / Q000378:metabolism*; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D008562:Membrane Glycoproteins; D010455:Peptides / Q000737:chemistry; D011485:Protein Binding; D011971:Receptors, Immunologic / Q000378:metabolism; D054340:Receptors, KIR; D054345:Receptors, KIR2DL4; D013601:T-Lymphocytes / Q000378:metabolism*; D000097625:HLA-E Antigens
D015703:Antigens, CD; D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D008562:Membrane Glycoproteins; D010455:Peptides; D011971:Receptors, Immunologic; D054340:Receptors, KIR; D054345:Receptors, KIR2DL4; D000097625:HLA-E Antigens; C515079:KIR2DL4 protein, human; C105299:LILRB1 protein, human; C491341:LILRB2 protein, human