title: Predictive value of serial platelet count and VEGF determination for the management of DIC in the Crow-Fukase (POEMS) syndrome.
abstract: We report a case of a 62-year-old man diagnosed as Crow-Fukase syndrome (POEMS syndrome), in which the serial platelet count and vascular endothelial growth factor (VEGF) concentration were determined before and during the state of disseminated intravascular coagulation (DIC). The serum VEGF concentration was noted to be gradually decreased prior to DIC, after which it abruptly decreased with a corresponding drop in platelet count upon the onset of DIC. The physiological effects of VEGF are viewed as one of the causative factors in DIC and its abrupt and excessive release may have caused the exacerbation of the patient's clinical symptoms.
authors.affiliation: Third Department of Internal Medicine, Kagoshima University, Kagoshima.
authors.forename: Takashi
authors.initials: T
authors.lastname: Tokashiki
authors.forename: Teruto
authors.initials: T
authors.lastname: Hashiguchi
authors.forename: Kimiyoshi
authors.initials: K
authors.lastname: Arimura
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Eiraku
authors.forename: Ikuro
authors.initials: I
authors.lastname: Maruyama
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Osame
mesh_terms: D000991:Antithrombins / Q000627:therapeutic use; D001120:Arginine / Q000031:analogs & derivatives; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000503:physiopathology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000627:therapeutic use; D008875:Middle Aged; D016878:POEMS Syndrome / Q000188:drug therapy / Q000378:metabolism*; D010875:Pipecolic Acids / Q000627:therapeutic use; D010976:Platelet Count; D011237:Predictive Value of Tests; D013449:Sulfonamides; D042461:Vascular Endothelial Growth Factor A / Q000097:blood* / Q000502:physiology
chemical_list: D000991:Antithrombins; D005938:Glucocorticoids; D010875:Pipecolic Acids; D013449:Sulfonamides; D042461:Vascular Endothelial Growth Factor A; D008776:Methylprednisolone Hemisuccinate; D001120:Arginine; C031942:argatroban