title: Analysis of polymorphic patterns in candidate genes in Israeli patients with prostate cancer.
abstract: BACKGROUND
  The precise genes involved in conferring prostate cancer risk in sporadic and familial cases are not fully known.
  
  
  OBJECTIVE
  To evaluate the genetic profile within several candidate genes of unselected prostate cancer cases and to correlate this profile with disease parameters.
  
  
  METHODS
  Jewish Israeli prostate cancer patients (n = 224) were genotyped for polymorphisms within candidate genes: p53, ER, VDR, GSTT1, CYP1A1, GSTP1, GSTM1, EPHX and HPC2/ELAC2, followed by analysis of the genotype with relevant clinical and pathologic parameters.
  
  
  RESULTS
  The EPHX gene His113 allele was detected in 21.4% (33/154) of patients in whom disease was diagnosed above 61 years, compared with 5.7% (4/70) in earlier onset disease (P < 0.001). Within the group of late-onset disease, the same allele was noted in 5.5% (2/36) with grade I tumors compared with 18% (34/188) with grade II and up (P = 0.004). All other tested polymorphisms were not associated with a distinct clinical or pathologic feature in a statistically significant manner.
  
  
  CONCLUSIONS
  In Israeli prostate cancer patients, the EPHX His113 allele is seemingly associated with a more advanced, late-onset disease. These preliminary data need to be confirmed by a larger and more ethnically diverse study.
authors.affiliation: Institute of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Arie
authors.initials: A
authors.lastname: Figer
authors.forename: Tal
authors.initials: T
authors.lastname: Friedman
authors.forename: Ayse Esra
authors.initials: AE
authors.lastname: Manguoglu
authors.forename: Dov
authors.initials: D
authors.lastname: Flex
authors.forename: Amnon
authors.initials: A
authors.lastname: Vazina
authors.forename: Ilia
authors.initials: I
authors.lastname: Novikov
authors.forename: Avi
authors.initials: A
authors.lastname: Shtrieker
authors.forename: A Ami
authors.initials: AA
authors.lastname: Sidi
authors.forename: Thomas
authors.initials: T
authors.lastname: Tichler
authors.forename: Einat Even
authors.initials: EE
authors.lastname: Sapir
authors.forename: Jack
authors.initials: J
authors.lastname: Baniel
authors.forename: Eitan
authors.initials: E
authors.lastname: Friedman
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005838:Genotype; D006801:Humans; D007585:Jews; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics*