The molecular mystery of neuronal migration: FAK and Cdk5.
The basic building blocks of a cell are its cytoskeletal proteins, the orderly but dynamic organization of which is essential. How signalling molecules regulate the cytoskeleton in the developing nervous system is still largely unknown. A recent breakthrough sheds light on a pathway involving Cdk5 (cyclin-dependent kinase 5) and FAK (focal adhesion kinase), demonstrating their role in regulating microtubule structure and thus nuclear positioning in radially migrating cortical neurones.
Nikolic
Margareta
M
MRC Centre for Developmental Neurobiology, New Hunt's House, King's College London, London SE1 1UL, UK. margareta.nikolic@kcl.ac.uk
D000818:Animals; D002465:Cell Movement; D051360:Cyclin-Dependent Kinase 5; D018844:Cyclin-Dependent Kinases / Q000502:physiology*; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000201:enzymology* / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D015398:Signal Transduction
D009419:Nerve Tissue Proteins; C089495:neuronal Cdk5 activator (p25-p35); D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C496050:PTK2 protein, human; D051360:Cyclin-Dependent Kinase 5; C495905:CDK5 protein, human; D018844:Cyclin-Dependent Kinases