Mechanisms of neurotrophin receptor vesicular transport.
Accumulating evidence has indicated that neurotrophin receptor trafficking plays an important role in neurotrophin-mediated signaling in developing as well as mature neurons. However, little is known about the molecular mechanisms and the components of neurotrophin receptor vesicular transport. This article will describe how neurotrophin receptors, Trk and p75 neurotrophin receptor (p75NTR), are intimately involved in the axonal transport process. In particular, the molecules that may direct Trk receptor trafficking in the axon will be discussed. Finally, potential mechanisms by which receptor-containing vesicles link to molecular cytoskeletal motors will be presented.
Yano
Hiroko
H
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Departments of Cell Biology, Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA. yano@saturn.med.nyu.edu
Chao
Moses V
MV
D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D008954:Models, Biological; D020409:Molecular Motor Proteins / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D015513:Oncogene Proteins / Q000378:metabolism; D010525:Peripheral Nerves / Q000166:cytology / Q000378:metabolism; D011485:Protein Binding; D021381:Protein Transport / Q000502:physiology; D017475:Receptors, Nerve Growth Factor / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D033921:Vesicular Transport Proteins / Q000378:metabolism
D020409:Molecular Motor Proteins; D015513:Oncogene Proteins; D017475:Receptors, Nerve Growth Factor; D033921:Vesicular Transport Proteins; C065400:oncogene protein trk