title: Vaccines in leishmaniasis: advances in the last five years.
abstract: The leishmaniases are a group of diseases caused by protozoa of the genus Leishmania which affects millions of people worldwide. The leishmaniases are transmitted to the vertebrate hosts by phlebotomine sand flies. In this review, we focus on clinical aspects of the leishmaniases and on the immune response against the parasite, both in animal models and humans. These aspects are of key importance to understand the many attempts to obtain an effective vaccine against Leishmania. We considered the last advances in new generation vaccines, including the use of new adjuvants to improve the protective response against the parasite. Finally, the possibility to use components of the sand fly saliva as part of vaccines against the infection by Leishmania is mentioned.
authors.affiliation: Instituto de Ciências da Saúde- Universidade Federal da Bahia, Salvador, Bahia, Brazil. brodskyn@cpqgm.fiocruz.br
authors.forename: Cláudia
authors.initials: C
authors.lastname: Brodskyn
authors.forename: Camila I
authors.initials: CI
authors.lastname: de Oliveira
authors.forename: Aldina
authors.initials: A
authors.lastname: Barral
authors.forename: Manoel
authors.initials: M
authors.lastname: Barral-Netto
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D006801:Humans; D007891:Leishmania / Q000276:immunology / Q000472:pathogenicity; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy / Q000469:parasitology / Q000517:prevention & control*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy / Q000469:parasitology / Q000517:prevention & control*; D016052:Protozoan Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D000981:Antiprotozoal Agents; D016052:Protozoan Vaccines