[Use of guinea pigs for assessing the efficacy of vaccines against Lassa fever].
The use of guinea pigs as a laboratory model was proven to be appropriate in investigating the vaccines developed against Lassa fever at the preclinical study stage. An adapted variant of Lassa virus was cultivated, which caused death of guinea pigs with respect for an agent's dose. Finally, it was shown to be possible to investigate the immunogenic and protective properties of the inactivated antigen of Lassa virus in experiments with guinea pigs.
Firsova
I V
IV
Shatokhina
I V
IV
Borisevich
I V
IV
Evseev
A A
AA
Maksimov
V A
VA
Pantiukhov
V B
VB
Khmelev
A L
AL
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D007835:Lassa Fever / Q000517:prevention & control*; D007836:Lassa virus / Q000276:immunology; D008297:Male; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
D000956:Antigens, Viral; D014765:Viral Vaccines