title: PRECiSe (priming reduced extracorporeal circulation setup): results of a safety study.
abstract: BACKGROUND
  Different low-priming systems limited to coronary artery bypass grafting (CABG) have been introduced. We describe the priming reduce d extracorporeal circulation setup (PRECiSe), a new low-priming system that supplies all of the features of cardiopulmonary bypass.
  
  
  METHODS
  PRECiSe incorporates the DeltaStream diagonal pump, which pumps blood from the right atrium to the aorta via a membrane oxygenator and a filter. The system is placed beneath the patient's head, resulting in extremely short tubing lengths. A reservoir allows the use of suckers and vents. Autologous blood priming further reduces hemodilution.
  
  
  RESULTS
  In the safety study, the system was used for extracorporeal circulation in 11 patients undergoing CABG without the occurrence of any adverse events. By using the PRECiSe system, we reduced the mean priming volume to 268.5 mL, resulting in minimal hemodilution and transfusion requirements.
  
  
  CONCLUSIONS
  The use of PRECiSe for extracorporeal circulation in CABG is safe and reduces priming volume as well as transfusion requirements. Further studies are necessary to investigate the clinical benefit for patients as well a s the use of the system in open heart procedures.
authors.affiliation: Department of Cardiovascular Surgery, Charité, Humboldt-University Berlin, Berlin, Germany. sven.beholz@charite.de
authors.forename: Sven
authors.initials: S
authors.lastname: Beholz
authors.forename: Michael
authors.initials: M
authors.lastname: Kessler
authors.forename: Wolfgang F
authors.initials: WF
authors.lastname: Konertz
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage; D007611:Aprotinin / Q000008:administration & dosage; D001803:Blood Transfusion; D002315:Cardiopulmonary Bypass / Q000295:instrumentation / Q000379:methods; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000295:instrumentation*; D004867:Equipment Design; D005112:Extracorporeal Circulation / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D005240:Feasibility Studies; D006400:Hematocrit; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged
chemical_list: D000925:Anticoagulants; D006493:Heparin; D007611:Aprotinin