title: Chronic zinc deficiency induces an antioxidant adaptive response in rat lung.
abstract: Few studies are available about the role of dietary zinc (Zn) in respiratory diseases. Adult male rats were divided into 2 groups and fed respectively a moderate Zn-deficient diet and a Zn-adequate control diet. In lung tissue at 2 months, thiobarbituric acid-reactive species (TBARS), total glutathione, glutathione disulfide, protein carbonyls, metallothionein, and the activities of glutathione peroxidase (GPx), catalase, CuZn-superoxide dismutase (CuZnSOD) and glucose-6-phosphate dehydrogenase (G-6-PDH) were increased, but protein thiols decreased. In lung tissue at 4 months, TBARS, metallothionein, and the activities of CuZnSOD, Mn-superoxide dismutase (MnSOD) increased. The activities GPx, catalase, G-6-PDH were lower than control group. The changes were accompanied by histological alterations in Zn-deficient lung. The results provide evidence of the pro-oxidative effects of Zn-deficiency in lung, and suggest that the time of treatment play a key role in determining lung susceptibility to oxidative stress.
authors.affiliation: Departamento de Bioquímica y Ciencias Biológicas, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Argentina.
authors.forename: Nidia N
authors.initials: NN
authors.lastname: Gomez
authors.forename: María R
authors.initials: MR
authors.lastname: Fernandez
authors.forename: Fanny
authors.initials: F
authors.lastname: Zirulnik
authors.forename: Esteban
authors.initials: E
authors.lastname: Gil
authors.forename: Luis
authors.initials: L
authors.lastname: Scardapane
authors.forename: Marta S
authors.initials: MS
authors.lastname: Ojeda
authors.forename: María S
authors.initials: MS
authors.lastname: Gimenez
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001835:Body Weight; D003677:Deficiency Diseases / Q000378:metabolism*; D004032:Diet; D007501:Iron / Q000032:analysis; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009929:Organ Size; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D015032:Zinc / Q000032:analysis / Q000172:deficiency* / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; D007501:Iron; D015032:Zinc