title: [High doses of steroids in the management of caustic esophageal burns in children].
abstract: Esophageal burns are frequent in some countries. Esophageal stricture is a severe complication after caustic ingestion. Its frequency is estimated to 5% and reaches 47% in severe esophagitis.
  
  
  OBJECTIVE
  To study the influence of management of severe esophageal burns with high doses of steroids in the occurrence of esophageal stricture through the experience of an endoscopic unit.
  
  
  METHODS
  Twenty-six children with a mean age of 3.5 years (15 months-8 years) with a second b- (N =22) or a third-degree (N =4) esophageal burns due to accidental ingestion of a caustic substance were included between 1993 and 1999. Corrosive substances ingested were sodium hydroxide (N =17), bleach (N =4), alkali (N =3), others (N =2). Upper GI endoscopy was performed in 17 children within the 24 hours of caustic ingestion and within the first 48 hours in all cases. All patients received methylprednisolone (1 g/1.73 m2/day) plus cimetidine and ampicillin plus early oral feeding resumption.
  
  
  RESULTS
  Three children (2 grade II et one grade I) were not controlled on day 30 of the protocol and have then been excluded. The remaining 23 children were divided in two groups depending on the upper GI endoscopic results: group I of 12 patients completely or partially healed and group II of 11 patients who developed an esophageal stricture. No difference was observed between the two groups with regard to the delay between caustic ingestion and the start of treatment and the number of shots of methylprednisolone. Second b- degree esophagitis complicated with an esophageal stricture underwent a median of five esophageal dilations (1-12). After a median follow-up of three years, four of them have a normal esophagus. All children with a third-degree esophagitis developed an esophageal stricture. One had a surgical replacement of the esophagus with a segment of colon with good outcome. The three others underwent a median of seven esophageal dilations (5-10). One of them has a normal esophagus after a follow-up of five years while the two others were lost to follow-up.
  
  
  CONCLUSIONS
  High dose of corticosteroids seems to improve second b-degree esophagitis prognosis and may prevent from esophageal stricture.
authors.affiliation: Service de médecine infantile C, hôpital d'enfants de Tunis, Bab Saadoun, 1007 Tunis Jebbari, Tunisie. samir.boukthir@rns.tn
authors.forename: S
authors.initials: S
authors.lastname: Boukthir
authors.forename: I
authors.initials: I
authors.lastname: Fetni
authors.forename: S Mazigh
authors.initials: SM
authors.lastname: Mrad
authors.forename: M A
authors.initials: MA
authors.lastname: Mongalgi
authors.forename: A
authors.initials: A
authors.lastname: Debbabi
authors.forename: S
authors.initials: S
authors.lastname: Barsaoui
mesh_terms: D002057:Burns, Chemical / Q000150:complications / Q000188:drug therapy*; D002424:Caustics / Q000506:poisoning*; D002648:Child; D002675:Child, Preschool; D016099:Endoscopy, Gastrointestinal; D004940:Esophageal Stenosis / Q000209:etiology*; D004947:Esophagus / Q000293:injuries*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D002424:Caustics; D005938:Glucocorticoids; D008775:Methylprednisolone