Clonazepam associated retinopathy.
OBJECTIVE
To report a case of retinopathy associated with the longterm intake of the antiepileptic drug clonazepam.


METHODS
Case report.


RESULTS
A 36-year-old woman, with a history of long-term use of the antiepileptic drug clonazepam developed subtle visual disturbances. Funduscopy revealed areas of mild depigmentation of the retinal pigment epithelium throughout the posterior pole bilaterally corresponding to transmission hyperfluorescence on fluorescein angiography. There was no history of any inherited retinal degenerative disease and no other known agent responsible for retinal toxicity had been used.


CONCLUSIONS
The longstanding intake of the antiepileptic drug clonazepam may be associated with the development of toxic retinopathy.
Gatzonis
Sta
S
Department of Ophthalmology, Hippocration Hospital, Athens, Greece.
Karadimas
P
P
Gatzonis
Sty
S
Bouzas
E A
EA
D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D002998:Clonazepam / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D012164:Retinal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D014786:Vision Disorders / Q000139:chemically induced / Q000175:diagnosis / Q000628:therapy; D014792:Visual Acuity
D000927:Anticonvulsants; D002998:Clonazepam