Synthesis and stability of oligonucleotides containing acyclic achiral nucleoside analogues with two base moieties.
[structure: see text] Nucleotide building blocks with two base moieties were synthesized and incorporated into oligonucleotides. One of the two bases is involved in base pairing within the double helix, while the other base is sticking out of the minor groove. This system may be used for presenting sequence information at the outside of the helix.
Wu
Tongfei
T
Laboratory of Medicinal Chemistry, Rega Institute for Medicinal Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
Froeyen
Matheus
M
Schepers
Guy
G
Mullens
Kristof
K
Rozenski
Jef
J
Busson
Roger
R
Van Aerschot
Arthur
A
Herdewijn
Piet
P
D020029:Base Pairing; D001665:Binding Sites; D004247:DNA / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000138:chemical synthesis / Q000737:chemistry*; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry
D009705:Nucleosides; D009841:Oligonucleotides; D004247:DNA