title: Analyzing sleep abnormalities in HIV-infected patients treated with Efavirenz.
abstract: Ambulatory electroencephalogram monitoring was performed for 18 HIV-infected subjects treated with efavirenz with and without insomnia and for 13 healthy control subjects. All patients receiving efavirenz had longer sleep latencies and shorter duration of deep sleep, although poor sleepers also showed reduced sleep efficiency and shorter duration of rapid eye movement sleep. Efavirenz plasma levels were higher in patients with insomnia and/or reduced sleep efficiency.
authors.affiliation: Service of Infectious Diseases, Hospital Carlos III, Instituto de Salud Carlos III, Madrid, Spain.
authors.forename: Lucía
authors.initials: L
authors.lastname: Gallego
authors.forename: Pablo
authors.initials: P
authors.lastname: Barreiro
authors.forename: Rafael
authors.initials: R
authors.lastname: del Río
authors.forename: Daniel
authors.initials: D
authors.lastname: González de Requena
authors.forename: Apolinar
authors.initials: A
authors.lastname: Rodríguez-Albariño
authors.forename: Juan
authors.initials: J
authors.lastname: González-Lahoz
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
mesh_terms: D000328:Adult; D000480:Alkynes; D048588:Benzoxazines; D003521:Cyclopropanes; D004569:Electroencephalography; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008297:Male; D010078:Oxazines / Q000009:adverse effects* / Q000627:therapeutic use; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced*; D012894:Sleep Stages / Q000187:drug effects*; D012893:Sleep Wake Disorders / Q000139:chemically induced
chemical_list: D000480:Alkynes; D048588:Benzoxazines; D003521:Cyclopropanes; D010078:Oxazines; D018894:Reverse Transcriptase Inhibitors; C098320:efavirenz