title: Ethical and legal issues in therapeutic cloning and the study of stem cells.
abstract: Therapeutic cloning is a new technology with great medical potential, particularly in the area of transplantation medicine. It involves the transfer of the nucleus of a patient's cell into an enucleated donor oocyte for the purpose of generating an embryo. This embryo is allowed to grow until the blastocyst stage, at which time stem cells can be obtained and differentiated into the tissue needed. Stem cells can also be obtained from adult tissues, as they seem to have sufficient plasticity to use for the stated purpose. A literature review was performed, and it is clear that the main controversy regarding the use of stem cells is the origin. Few people would object to their use if obtained from adult tissues; however, many oppose harvesting them from embryos in the blastocyst stage regardless of whether 1) they are obtained from surplus embryos donated by couples after assisted reproductive techniques, or 2) they are specially manufactured for research purposes. The central reason is the consideration that embryos should be treated as full humans from the moment of fertilization. This argument is also at the bottom of an older discussion regarding the validity of abortion. There is no consensus at the present time in this regard, and it is unlikely one will be forthcoming in the future. Arguments on both sides of the issue are presented, but emphasis is made on the need for using this technology for research purposes because of its potential value as a therapeutic tool.
authors.affiliation: Dirección de Investigación, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. rlisker@quetzal.innsz.mx
authors.forename: Rubén
authors.initials: R
authors.lastname: Lisker
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D019976:Cloning, Organism / Q000941:ethics* / Q000331:legislation & jurisprudence / Q000379:methods; D026689:Ethical Analysis; D004992:Ethics, Medical; D006801:Humans; D013234:Stem Cells