title: Identifying constraints that govern cell behavior: a key to converting conceptual to computational models in biology?
abstract: Cells must abide by a number of constraints. The environmental constrains of cellular behavior and physicochemical limitations affect cellular processes. To regulate and adapt their functions, cells impose constraints on themselves. Enumerating, understanding, and applying these constraints leads to a constraints-based modeling formalism that has been helpful in converting conceptual models to computational models in biology. The continued success of the constraints-based approach depends upon identification and incorporation of new constraints to more accurately define cellular capabilities. This review considers constraints in terms of environmental, physicochemical, and self-imposed regulatory and evolutionary constraints with the purpose of refining current constraints-based models of cell phenotype.
authors.affiliation: Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
authors.forename: Markus W
authors.initials: MW
authors.lastname: Covert
authors.forename: Iman
authors.initials: I
authors.lastname: Famili
authors.forename: Bernhard O
authors.initials: BO
authors.lastname: Palsson
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D002468:Cell Physiological Phenomena; D004777:Environment; D019143:Evolution, Molecular; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology*