title: Apoptosis: escaping strategies in human skin cancer (Review).
abstract: Apoptosis must be considered a rescue mechanism that controls the integrity of the cell erasing aberrant clones and it is likely that failure of apoptosis constitutes a key factor responsible for tumour formation, progression and resistance to drugs. Several genes (e.g. survivin, bcl-2 family, p53) are involved in these pathways. Much work still needs to be done to identify the molecular pathway of apoptosis resistance but restoration of the apoptotic response represents a crucial new therapeutic target for cancer treatment.
authors.affiliation: Institute of Dentistry and Surgery, Faculty of Medicine, University of Modena, Modena, Italy.
authors.forename: Luca
authors.initials: L
authors.lastname: Giannetti
authors.forename: Ugo
authors.initials: U
authors.lastname: Consolo
authors.forename: Cristina
authors.initials: C
authors.lastname: Magnoni
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Lo Muzio
mesh_terms: D017209:Apoptosis; D018450:Disease Progression; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D009154:Mutation; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*