[Analysis of LRP15 Gene Expression Pattern and Its Expression in Leukemia Cells].
To explore the possible function of LRP15 gene in carcinogenesis and its significance in the classification and prognosis of leukemia, the expression pattern of LRP15 in normal tissues, tumor tissues and cell lines was detected with SAGE and gene expression database provided by NCBI and NCI respectively. RT-PCR was used to detect the expression of LRP15 in leukemia patients. The results showed that LRP15 was expressed in different tissues and tumor cell lines, the positive rate of LRP15 in immature blood cells was higher than that of mature blood cells and the positive rate of M(1), M(2) and M(3) was higher than that of other AML subtypes (P < 0.01), the expression of LRP15 in refractory leukemia was higher than that of de novo leukemia. The results suggest that LRP15 may play an important role in carcinogenesis, AML classification and acute leukemia prognosis.
Xu
Zhou-Min
ZM
Department of Hematology, Shanghai Corps Hospital, Chinese People's Armed Police Army, Shanghai 201103, China. xuzhoumin@yahoo.com.cn
Yu
Li
L
Lu
Xue-Chun
XC
Dou
Li-Ping
LP
Li
Ming
M
Yang
Long
L
Zhao
Yu
Y
Li
Hong-Hua
HH
Lü
Ming
M
Lü
You-Ling
YL
Lou
Fang-Ding
FD
D045744:Cell Line, Tumor; D020869:Gene Expression Profiling; D006801:Humans; D007938:Leukemia / Q000209:etiology / Q000235:genetics*; D009363:Neoplasm Proteins; D011506:Proteins / Q000235:genetics*
C477813:LRRC3B protein, human; D009363:Neoplasm Proteins; D011506:Proteins