MHC class II signaling in antigen-presenting cells.
The MHC class II molecules have been recognized as signaling receptors for more than a decade, and recent work has revealed the importance of their signaling for the immune response. Today, we know that the function of MHC class II molecules on antigen-presenting cells (APCs) is not limited to their role as antigen-presenting structures; they are flexible receptors that, by triggering a variety of signaling pathways, can regulate APC activities from proliferation and maturation to apoptosis. Recent advances have provided insights into how these molecules might accommodate such regulation.
Al-Daccak
Reem
R
Institut Universitaire d'Hématologie, IFR105, Hôpital Saint Louis AP-HP, 10 rue Claude Vellefaux, 75475 Paris, France. Reem.Al-Daccak@bhdc.jussieu.fr
Mooney
Nuala
N
Charron
Dominique
D
D000818:Animals; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000502:physiology*; D021962:Membrane Microdomains / Q000502:physiology; D011493:Protein Kinase C / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011946:Receptors, Antigen / Q000502:physiology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology
D000949:Histocompatibility Antigens Class II; D011946:Receptors, Antigen; D011505:Protein-Tyrosine Kinases; D011493:Protein Kinase C