Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients.
PCGEM1 is a novel, highly prostate tissue-specific, androgen-regulated gene. Here, we demonstrate that PCGEM1 expression is significantly higher in prostate cancer (CaP) cells of African-American men than in Caucasian-American men (P=0.0002). Further, increased PCGEM1 expression associates with normal prostate epithelial cells of CaP patients with a family history of CaP (P=0.0400). PCGEM1 overexpression in LNCaP and in NIH3T3 cells promotes cell proliferation and a dramatic increase in colony formation, suggesting a biological role of PCGEM1 in cell growth regulation. Taken together, the cell proliferation/colony formation-promoting functions of PCGEM1 and the association of its increased expression with high-risk CaP patients suggest the potential roles of PCGEM1 in CaP onset/progression, especially in these high-risk groups.
Petrovics
Gyorgy
G
Department of Surgery, Center for Prostate Disease Research, US Military Cancer Institute, Uniformed Services University of the Health Sciences, Bethesda, MD 20814-4799, USA. gpetrovics@cpdr.org
Zhang
Wei
W
Makarem
Mazen
M
Street
Jesse P
JP
Connelly
Roger
R
Sun
Leon
L
Sesterhenn
Isabell A
IA
Srikantan
Vasantha
V
Moul
Judd W
JW
Srivastava
Shiv
S
D000818:Animals; D002455:Cell Division; D045744:Cell Line, Tumor; D018450:Disease Progression; D006801:Humans; D008297:Male; D051379:Mice; D041681:NIH 3T3 Cells; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D009928:Organ Specificity; D011467:Prostate / Q000378:metabolism* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000145:classification / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated
D009363:Neoplasm Proteins; C416084:PCGEM1 non-coding RNA, human; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated