title: Suppression by Hydrangeae Dulcis Folium of D-galactosamine-induced liver injury in vitro and in vivo.
abstract: Hydrangeae Dulcis Folium, the fermented and dried leaves of Hydrangea macrophylla SER. var. thunbergii MAKINO, suppressed D-galactosamine-induced liver injury by 85.2% when added to the diet at 1% and fed to rats for fifteen days. The hepatoprotective effect is more potent than that of a milk thistle extract and turmeric powder. Some fractionated extracts showed hepatoprotective activity in the D-galactosamine-induced in vitro liver injury model.
authors.affiliation: Kyowa Hakko Kogyo Co., Ltd., Tsukuba Research Laboratories, Ibaraki, Japan. ryuusuke.nakagiri@kyowa.co.jp
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Nakagiri
authors.forename: Erika
authors.initials: E
authors.lastname: Hashizume
authors.forename: Shun
authors.initials: S
authors.lastname: Kayahashi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sakai
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Kamiya
mesh_terms: D000410:Alanine Transaminase / Q000032:analysis* / Q000097:blood; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D005688:Galactosamine / Q000633:toxicity; D031966:Hydrangea / Q000737:chemistry*; D008099:Liver / Q000187:drug effects* / Q000293:injuries; D008107:Liver Diseases / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D005688:Galactosamine; D000410:Alanine Transaminase