Restoring functions of tumor suppressors with small molecules.
Developing small molecule inhibitors of oncoproteins, which are activated in tumor cells, is a newly popular strategy for cancer-related drug discovery. The complementary strategy, developing small molecules that restore the function of missing tumor suppressors, is much more difficult to realize. However, in this issue of Cancer Cell, Kau et al. report the discovery of small molecules that reverse some cellular consequences of the loss of the tumor suppressor PTEN.
Smukste
Inese
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Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA.
Stockwell
Brent R
BR
D021581:Active Transport, Cell Nucleus / Q000502:physiology; D000818:Animals; D016588:Anticarcinogenic Agents / Q000378:metabolism / Q000493:pharmacokinetics*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D029941:Fish Proteins; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; D006801:Humans; D028884:Karyopherins / Q000378:metabolism; D050356:Lipid Metabolism; D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010766:Phosphorylation; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism; D000097606:Exportin 1 Protein
D016588:Anticarcinogenic Agents; D004268:DNA-Binding Proteins; D029941:Fish Proteins; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors; D028884:Karyopherins; D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases; D017027:Protein Tyrosine Phosphatases; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D000097606:Exportin 1 Protein; C085126:FOXO1 protein, human; C436505:Pten protein, pufferfish