title: Intravenous infusion anesthesia with Propofol-Midazolam-fentanyl for experimental surgery in swine.
abstract: There is a need for prolonged anesthesia procedures in experimental surgery. Animals in this study received fentanyl, Midazolam, and Propofol administered by continuous intravenous infusion for anesthesia along with controlled ventilation. Time of anesthesia was 413 +/- 95 min. Animals could be extubated 20 +/- 12 min after operation. Animals recovered completely from anesthesia by day 1 after surgery with almost normal physical activity. This study clearly shows that intravenous infusion anesthesia is safe and easy to handle in prolonged anesthesia for experimental surgery in swine. This anesthetic protocol can also be used for intraoperative transportation.
authors.affiliation: Department of General Surgery and Transplantation, University Hospital, Essen, Germany.
authors.forename: Gernot M
authors.initials: GM
authors.lastname: Kaiser
authors.forename: Nils R
authors.initials: NR
authors.lastname: Frühauf
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhang
authors.forename: Stephanie
authors.initials: S
authors.lastname: Westermann
authors.forename: Ines
authors.initials: I
authors.lastname: Bolle
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Oldhafer
authors.forename: Christoph E
authors.initials: CE
authors.lastname: Broelsch
mesh_terms: D000005:Abdomen / Q000601:surgery; D000771:Anesthesia, Intravenous / Q000379:methods* / Q000401:mortality; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D005260:Female; D005283:Fentanyl / Q000494:pharmacology*; D007262:Infusions, Intravenous; D008874:Midazolam / Q000494:pharmacology*; D015742:Propofol / Q000494:pharmacology*; D013045:Species Specificity; D034421:Sus scrofa
chemical_list: D018686:Anesthetics, Intravenous; D008874:Midazolam; D005283:Fentanyl; D015742:Propofol