Prediagnostic human T lymphotropic virus type I provirus loads were highest in Jamaican children who developed seborrheic dermatitis and severe anemia.
In a recent clinical analysis of 308 Jamaican children, human T lymphotropic virus type I (HTLV-I) infection was found to be associated with significantly higher incidence rates of seborrheic dermatitis, eczema, and persistent hyperreflexia of the lower limbs and with nonsignificantly increased rates of severe anemia and abnormal lymphocytes. Results of examination of HTLV-I viral markers in the 28 HTLV-I-infected children provided virologic support for the epidemiologic associations of HTLV-I with seborrheic dermatitis and severe anemia in childhood.
Maloney
Elizabeth M
EM
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA. maloneyb@mail.nih.gov
Nagai
Masahiro
M
Hisada
Michie
M
Soldan
Samantha S
SS
Goebel
P Bradley
PB
Carrington
Mary
M
Sawada
Takashi
T
Brennan
Meghan B
MB
Cranston
Beverley
B
Hanchard
Barrie
B
Jacobson
Steven
S
D000740:Anemia / Q000453:epidemiology / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D002675:Child, Preschool; D015331:Cohort Studies; D015897:Comorbidity; D012628:Dermatitis, Seborrheic / Q000453:epidemiology / Q000209:etiology*; D018450:Disease Progression; D015490:HTLV-I Infections / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D015994:Incidence; D007223:Infant; D007563:Jamaica / Q000453:epidemiology; D011533:Proviruses / Q000302:isolation & purification*; D012307:Risk Factors; D019562:Viral Load
D015415:Biomarkers