title: Influence of corneal thickness on comparative intraocular pressure measurements with Goldmann and non-contact tonometers in keratoconus.
abstract: BACKGROUND
  The influence of corneal thickness and curvature on the difference between intraocular pressure (IOP) measurements obtained with non-contact (NCT) and those with the Goldmann applanation tonometer (GAT) was studied in patients with keratoconus.
  
  
  METHODS
  We examined 113 patients with keratoconus. IOP was measured by the Canon TX 10 non-contact tonometer and the Goldmann tonometer, corneal curvature and thickness were obtained by Humphrey Automatic Refractometer Keratometer and Orbscan Version 3.0 Bausch & Lomb Surgical.
  
  
  RESULTS
  The IOP measured by NCT was significantly lower than that measured by GAT. The mean pachymetry of the thinnest point was 423.15 +/- 98.43 microm for the right eyes and 426.7 +/- 93.88 microm for the left eyes. The difference between NCT-GAT and corneal thickness showed a significant negative correlation (r = - 0.427, p < 0.0001; t = - 3.677, p < 0.0001). Values of NCT measurements were significantly increasing with corneal thickness (F = 6.505, p < 0.0001 for right eyes and F = 4.37, p = 0.004 for left eyes), whilst GAT measurements did not show a significant influence of the corneal thickness. The keratometry had no effect on the difference between NCT-GAT measurements (t = 1.090, p = 0.278).
  
  
  CONCLUSIONS
  The thin cornea has more influence on the measurement with NCT than GAT. The relative precision of NCT compared with GAT seems to be influenced by the corneal thickness.
authors.affiliation: University Eye Clinic Ljubljana, Slovenia. mirna.stabuc@kclj.si
authors.forename: Mirna
authors.initials: M
authors.lastname: Stabuc Silih
authors.forename: Marko
authors.initials: M
authors.lastname: Hawlina
mesh_terms: D000328:Adult; D019781:Corneal Topography; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D007640:Keratoconus / Q000503:physiopathology*; D008297:Male; D008365:Manometry / Q000295:instrumentation*; D008875:Middle Aged; D012029:Refraction, Ocular / Q000502:physiology; D012680:Sensitivity and Specificity