title: Subependymal giant cell astrocytoma with positive tuberin expression--case report.
abstract: An 11-year-old male presented with subependymal giant cell astrocytoma (SEGA) without other manifestations of tuberous sclerosis such as facial angiofibroma, epilepsy, or mental retardation. The diagnosis was "possible tuberous sclerosis complex" (TSC). Total resection of the tumor was performed. Immunohistochemical study revealed positive tuberin expression. In general, loss of tuberin is thought to be critical to the TSC phenotype. Our case demonstrated clear expression of tuberin in the SEGA specimen.
authors.affiliation: Department of Neurosurgery, Institute of Neurological Sciences, Tottori University School of Medicine, Yonago, Tottori, Japan. stabuchi@gj8.so-net.ne.jp
authors.forename: Sadaharu
authors.initials: S
authors.lastname: Tabuchi
authors.forename: Haruo
authors.initials: H
authors.lastname: Takigawa
authors.forename: Akira
authors.initials: A
authors.lastname: Oka
authors.forename: Masashi
authors.initials: M
authors.lastname: Mizuguchi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Horie
authors.forename: Takashi
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D001254:Astrocytoma / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D001932:Brain Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D002648:Child; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008866:Microsurgery / Q000379:methods; D019635:Neurosurgical Procedures / Q000379:methods; D012097:Repressor Proteins / Q000378:metabolism*; D014057:Tomography, X-Ray Computed; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins
chemical_list: D012097:Repressor Proteins; C000624653:TSC2 protein, human; D000077005:Tuberous Sclerosis Complex 2 Protein; D025521:Tumor Suppressor Proteins