HLA-G and lymphoproliferative disorders.
The immunomodulatory properties of the HLA-G molecule explain its relevance in malignancies. Our investigations in lymphoproliferative disorders show (i) a frequent and variable distribution of alternatively spliced HLA-G mRNA isoforms, (ii) a rare cell surface expression in diffuse large cell lymphomas with HLA class I loss in half of cases, and (iii) an increased serum level of sHLA-G in half of cases. The potential role of the microenvironment and/or tumoral process in HLA-G expression is discussed in the light of these data. HLA-G rather through its soluble isoform might provide a new way of immune evasion for lymphoid proliferations.
Amiot
Laurence
L
Laboratoire Universitaire d'Hématologie et de la Biologie des Cellules Sanguines, UPRES EA 22-33, Faculté de Médecine, Université de Rennes 1, Rennes, France. laurence.amiot@chu-rennes.fr
Le Friec
Gaëlle
G
Sebti
Yasmine
Y
Drénou
Bernard
B
Pangault
Céline
C
Guilloux
Valérie
V
Leleu
Xavier
X
Bernard
Marc
M
Facon
Thierry
T
Fauchet
Renée
R
D002455:Cell Division; D004797:Enzyme-Linked Immunosorbent Assay; D005091:Exons; D005434:Flow Cytometry; D006680:HLA Antigens / Q000097:blood / Q000276:immunology* / Q000502:physiology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000097:blood / Q000276:immunology* / Q000502:physiology*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000276:immunology* / Q000378:metabolism; D009101:Multiple Myeloma / Q000276:immunology; D020033:Protein Isoforms; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D020033:Protein Isoforms; D012333:RNA, Messenger