[Protective effect of propofol on liver during ischemia-reperfusion injury in patients undergoing liver surgery].
OBJECTIVE
To explore the protective effect of propofol on liver during hepatic ischemia/reperfusion injury (HIRI) and its mechanisms in patients undergoing liver surgery.


METHODS
Eighteen patients who were scheduled for selective hepatic surgery were randomly divided into control group (n=9) and propofol treatment group (n=9). Changes of several parameters in plasma and effects of propofol on them were observed before liver ischemia, at end of ischemia and at reperfusion for 25 minutes, parameters of which included superoxide dismutase (SOD), xanthine oxidase (XO), lipid peroxide (LPO) and alanine aminotransferase (ALT) activity, and the ultrastructure changes in liver tissue were observed under electron microscope at 25 minutes after reperfusion.


RESULTS
SOD activity decreased remarkably (P<0.01); XO activity, LPO concentration and ALT value increased significantly (P<0.01) during HIRI, and there were abnormal changes of the hepatic ultrastructure at 25 minutes after reperfusion. Afer treatment with propofol, the variation of all parameters were alleviated markedly (P<0.05 and P<0.01).


CONCLUSIONS
Propofol has protective effects on HIRI by reducing oxygen free radical level and inhibiting lipid peroxidation after hepatic ischemia/reperfusion in patients undergoing liver cancer surgery.
Lin
Li-na
LN
Department of Anesthesiology, First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325003, Zhejiang, China.
Wang
Wan-tie
WT
Wu
Jin-ze
JZ
Hu
Zheng-yang
ZY
Xie
Ke-jian
KJ
D000328:Adult; D002268:Carboxypeptidases / Q000097:blood; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008113:Liver Neoplasms / Q000098:blood supply / Q000601:surgery; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000627:therapeutic use*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000097:blood; D014969:Xanthine Oxidase / Q000097:blood
D016166:Free Radical Scavengers; D008054:Lipid Peroxides; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D002268:Carboxypeptidases; C019632:alanine carboxypeptidase; D015742:Propofol