Effects of perinatal simultaneous exposure to tributyltin (TBT) and p,p'-DDE [1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene) on male offspring of Wistar rats.
p,p'-DDE [1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene; DDE] and tributyltin (TBT) are ubiquitous in the environment and in Japan were shown to bioaccumulate in marine products. Thus these chemicals serve as a source of contaminant in the mammalian food chain. Fetuses and neonates through maternal ingestion may be exposed to DDE and TBT. Therefore, the effects of concurrent exposure to DDE and TBT were investigated in male Wistar rat offspring of dams ingesting these two contaminants. In this study, TBT suppressed the growth and delayed eye opening. However, both growth retardation and delayed eye opening produced by TBT failed to occur in the presence of DDE. Unexpectedly, the prostate weight of male rat offspring was significantly reduced with the administration of TBT but restored in the presence of DDE. These results indicate that TBT and DDE affected the development of male rat offspring following maternal exposure, and simultaneous administration of DDE prevented some of the observed effects of TBT, especially of an antagonistic nature, through a mechanism, still to be determined.
Makita
Yuji
Y
Department of Hygiene, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. ymakita@eisei.med.kyushu-u.ac.jp
Omura
Minoru
M
Ogata
Rika
R
D000818:Animals; D000831:Animals, Newborn; D003633:Dichlorodiphenyl Dichloroethylene / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005123:Eye / Q000187:drug effects / Q000254:growth & development; D005260:Female; D006128:Growth / Q000187:drug effects; D007306:Insecticides / Q000494:pharmacology*; D008297:Male; D009929:Organ Size; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011467:Prostate / Q000187:drug effects / Q000254:growth & development; D051381:Rats; D017208:Rats, Wistar / Q000254:growth & development; D014220:Trialkyltin Compounds / Q000494:pharmacology*
D007306:Insecticides; D014220:Trialkyltin Compounds; D003633:Dichlorodiphenyl Dichloroethylene; C011559:tributyltin