title: Reversal of nocturnal periodic breathing in primary pulmonary hypertension after lung transplantation.
abstract: Nocturnal periodic breathing (PB) closely resembling Cheyne-Stokes respiration in congestive heart failure has been reported to occur in end-stage primary pulmonary hypertension (PPH). We herein describe the clinical course of a 56-year-old female patient with PPH and severe hypoxemia, hypocapnia, and right ventricular compromise in whom sleep-disordered breathing (SDB) resolved after successful double-lung transplantation. This case illustrates the crucial roles of blood gas alterations and hemodynamic impairment in the emergence of PB in PPH, and is in favor of a genuine association between advanced right heart failure and the development of SDB.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Justus-Liebig University, Giessen. Richard.Schulz@innere.med.uni-giessen.de
authors.forename: Richard
authors.initials: R
authors.lastname: Schulz
authors.forename: Christine
authors.initials: C
authors.lastname: Fegbeutel
authors.forename: Horst
authors.initials: H
authors.lastname: Olschewski
authors.forename: Frank
authors.initials: F
authors.lastname: Rose
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Schäfers
authors.forename: Werner
authors.initials: W
authors.lastname: Seeger
mesh_terms: D002639:Cheyne-Stokes Respiration; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D016040:Lung Transplantation; D008875:Middle Aged; D017286:Polysomnography; D012891:Sleep Apnea Syndromes / Q000150:complications / Q000503:physiopathology*