Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice.
To determine its effect on intestinal tumorigenesis and the protumorigenic COX pathway in Apc(Min/+) mice, resveratrol was administered as a powdered admixture in the diet at 0, 4, 20, or 90 mg/kg body weight for 7 wk. In two separate experiments, resveratrol did not affect intestinal tumor load. It was stable in the diet under experimental conditions, circulated in the plasma as the glucuronide-conjugated form and reached the tumors as evidenced by significant decreases in PGE2 levels. However, immunohistochemical staining of intestinal tumors revealed no changes in COX-2 expression. This study demonstrates that resveratrol consumed ad libitum in the diet, does not modify tumorigenesis in Apc(Min/+) mice.
Ziegler
Carol C
CC
Department of Nutrition, University of Tennessee, Knoxville, TN, USA.
Rainwater
Leah
L
Whelan
Jay
J
McEntee
Michael F
MF
D011125:Adenomatous Polyposis Coli / Q000737:chemistry / Q000235:genetics*; D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D051546:Cyclooxygenase 2; D004032:Diet; D015232:Dinoprostone / Q000032:analysis; D020719:Glucuronides / Q000097:blood; D007414:Intestinal Neoplasms / Q000737:chemistry / Q000235:genetics*; D007527:Isoenzymes / Q000032:analysis; D007700:Kinetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D011451:Prostaglandin-Endoperoxide Synthases / Q000032:analysis; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics
D016588:Anticarcinogenic Agents; D020719:Glucuronides; D007527:Isoenzymes; D013267:Stilbenes; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D015232:Dinoprostone; D000077185:Resveratrol