title: Mycoplasma endocarditis: two case reports and a review.
abstract: We describe 2 patients with endocarditis for whom blood cultures and cardiac valve cultures were repeatedly sterile. Broad-range eubacterial polymerase chain reaction (PCR) amplification performed on cardiac valve specimens from these 2 patients detected DNA of Mycoplasma hominis, for one patient, and of Ureaplasma parvum, for the other patient. Three other cases of infective endocarditis caused by mycoplasmas were identified in the literature. It is important to rule out a diagnosis of mycoplasma endocarditis because the evolution of the disease may be fatal and it requires an adequate and specific antibiotic therapy.
authors.affiliation: Unité des Rickettsies, Faculté de Médecine, Université de la Méditerranée, and Fédération de Bactériologie, Virologie et Hygiène hospitalière, Hôpital de la Timone, Marseille, France.
authors.forename: Florence
authors.initials: F
authors.lastname: Fenollar
authors.forename: Valérie
authors.initials: V
authors.lastname: Gauduchon
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Casalta
authors.forename: Hubert
authors.initials: H
authors.lastname: Lepidi
authors.forename: François
authors.initials: F
authors.lastname: Vandenesch
authors.forename: Didier
authors.initials: D
authors.lastname: Raoult
mesh_terms: D000328:Adult; D004269:DNA, Bacterial / Q000032:analysis; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009175:Mycoplasma Infections / Q000188:drug therapy / Q000382:microbiology; D019535:Mycoplasma hominis / Q000235:genetics / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D014509:Ureaplasma / Q000235:genetics / Q000302:isolation & purification*; D016869:Ureaplasma Infections / Q000188:drug therapy / Q000382:microbiology
chemical_list: D004269:DNA, Bacterial