Ageing, repetitive genomes and DNA damage.
The mitochondrial production of reactive oxygen species is inversely proportional to longevity in animals. A key question now is, which molecules, among those that are oxidized, affect the lifespan of the organism most significantly?
Lieber
Michael R
MR
University of Southern California Norris Comprehensive Cancer Center, Room 5428, Department of Pathology, 1441 Eastlake Avenue, MC9176, Los Angeles, California 90033, USA. lieber@usc.edu
Karanjawala
Zarir E
ZE
D000375:Aging / Q000235:genetics*; D000818:Animals; D004249:DNA Damage / Q000235:genetics*; D006801:Humans; D008136:Longevity; D051379:Mice; D008928:Mitochondria / Q000235:genetics / Q000502:physiology; D017382:Reactive Oxygen Species; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*
D017382:Reactive Oxygen Species