Arylation of heterocycles via rhodium-catalyzed C-H bond functionalization.
[reaction: see text] A new method for the rhodium-catalyzed arylation of a variety of heterocycles has been developed. The reaction provided moderate to good yields of the arylated products. A preliminary mechanistic investigation of this reaction revealed the intermediacy of an isolable N-heterocyclic carbene complex.
Lewis
Jared C
JC
Center for New Directions in Organic Synthesis, Department of Chemistry, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA.
Wiedemann
Sean H
SH
Bergman
Robert G
RG
Ellman
Jonathan A
JA
D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D007093:Imidazoles / Q000138:chemical synthesis*; D008956:Models, Chemical; D012238:Rhodium / Q000737:chemistry*
D006571:Heterocyclic Compounds; D007093:Imidazoles; D012238:Rhodium