title: Post-initiation inhibition of MeIQx hepatocarcinogenesis in rats by cysteine.
abstract: Rats were administered cysteine at a dose of 100 mg/kg b.w. 5 times per week after 2-amino-3, 8-dimethylimidazo [4,5-f] quinoxaline (MeIQx) treatment. Significant decrease in numbers and areas of glutathione S-transferase placental form (GST-P)-positive foci, putative preneoplastic lesions, and silver-stained nucleolar organizer regions were evident in the livers of rats treated with cysteine after MeIQx treatment. Morever, post-initiation stage cysteine treatment resulted in decreased hepatic insulin-like growth factor (IGF)-I mRNA expression. Thus post-initiation cysteine treatment may exert chemopreventive effect on MeIQx hepatocarcinogenesis.
authors.affiliation: The first Department of Pathology, Osaka City University Medical School, Japan.
authors.forename: Motome
authors.initials: M
authors.lastname: Ogawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Wanibuchi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Nishkawa
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Yano
authors.forename: Shuzo
authors.initials: S
authors.lastname: Otani
authors.forename: Yukari
authors.initials: Y
authors.lastname: Totsuka
authors.forename: Keiji
authors.initials: K
authors.lastname: Wakabayashi
authors.forename: Dai
authors.initials: D
authors.lastname: Nakae
authors.forename: Shoji
authors.initials: S
authors.lastname: Fukushima
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D003545:Cysteine / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000032:analysis; D016158:Genes, p53; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D009697:Nucleolus Organizer Region / Q000187:drug effects; D011230:Precancerous Conditions / Q000517:prevention & control*; D011810:Quinoxalines / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D011810:Quinoxalines; D007334:Insulin-Like Growth Factor I; C036990:2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D003849:Deoxyguanosine; D003545:Cysteine