Squamous metaplasia of Paget's disease.
A patient had triple extramammary Paget's disease of both axillary and genital regions. Right inguinal lymphadenopathy was found 1 year after excision of all the skin lesions. Excisional biopsy of the lymph node demonstrated a mixture of Paget cells and atypical squamoid cells with horn pearls suggestive of keratinization. The squamoid cells were positive for cytokeratin 10, a marker of suprabasal epidermis, and also positive for laminin gamma2 which is often expressed in invasive squamous cell carcinoma. The coexistence of these different cells within the same tumour island suggested that the squamoid cells derived from metaplasia of Paget cells.
Miyakawa
T
T
Department of Dermatology, School of Medicine, Chiba University, 1-8-1 Inohana-cho, Chuo-ku, Chiba city 260-8670, Japan.
Togawa
Y
Y
Matushima
H
H
Nakamura
H
H
Kamada
N
N
Momota
Y
Y
Tochigi
N
N
Nikaido
T
T
Shinkai
H
H
Utani
A
A
D000368:Aged; D001365:Axilla; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D003937:Diagnosis, Differential; D005834:Genital Neoplasms, Male / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008679:Metaplasia / Q000473:pathology; D010145:Paget Disease, Extramammary / Q000473:pathology*; D012611:Scrotum / Q000473:pathology*