VEGF: a critical player in neurodegeneration.
VEGF is a prototype angiogenic factor, but recent evidence indicates that this growth factor also has direct effects on neural cells. Abnormal regulation of VEGF expression has now been implicated in several neurodegenerative disorders, including motoneuron degeneration. This has stimulated an increasing interest in assessing the therapeutic potential of VEGF as a neuroprotective agent for such neurodegenerative disorders.
Storkebaum
Erik
E
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium.
Carmeliet
Peter
P
D000818:Animals; D006801:Humans; D008954:Models, Biological; D009410:Nerve Degeneration / Q000503:physiopathology*; D019636:Neurodegenerative Diseases / Q000235:genetics; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000502:physiology*
D042461:Vascular Endothelial Growth Factor A