Poly(N,N,N-trimethylammoniumalkyl acrylamide chloride) based hydrogels for serum cholesterol reduction.
Hydrogels present an attractive alternative to nanoscale block copolymer aggregates and microscale resin beads as potential asystemic serum cholesterol reduction materials. Not only would the oral delivery of these materials be more pleasant than the sand-like bile salt anion sequestrant beads but also the hydrogel preparation is much simpler than the copolymer aggregate analogues [Cameron, N. S.; Eisenberg, A.; Brown, G. R. Biomacromolecules 2002, 3, 116-123. Cameron, N. S.; Eisenberg, A.; Brown, G. R. Biomacromolecules 2002, 3, 124-132]. Our goal was to explore these materials building on our experience with bulk resins and self-assembled copolymers. In this paper, following a brief introduction to hydrogels and their application to hypercholesterolemia, the synthesis, characterization, and preliminary glycocholate binding properties of poly(N,N,N-trimethylammoniumalkyl acrylamide chloride)gel are presented [Cameron, N. S.; Eisenberg, A.; Brown, G. R. Polym. Preprints 2002, 43, 771-772].
Cameron
Neil S
NS
Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montréal, Québec, Canada H3A 2K6, and Department of Chemistry, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario, Canada L2S 3A1.
Morin
Frederick G
FG
Eisenberg
Adi
A
Brown
G Ronald
GR
D000180:Acrylic Resins / Q000138:chemical synthesis* / Q000627:therapeutic use; D001665:Binding Sites; D002784:Cholesterol / Q000097:blood* / Q000378:metabolism; D006000:Glycocholic Acid / Q000378:metabolism; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis* / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000188:drug therapy; D036103:Nanotechnology; D010316:Particle Size; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis / Q000627:therapeutic use; D013057:Spectrum Analysis; D000099166:Polyacrylamides
D000180:Acrylic Resins; D002784:Cholesterol; D006000:Glycocholic Acid; D020100:Hydrogels; D000644:Quaternary Ammonium Compounds; D000099166:Polyacrylamides