[An experimental study on high intensity focused ultrasound combined with mitomycin treatment of bladder tumor].
OBJECTIVE
To study the therapeutic effect and synergistic inhibition effect of high intensity focused ultrasound in combination with mitomycin on T739 mice bladder tumor.


METHODS
BTT739 tumor-bearing mice receiving HIFU and/or mitomycin in two weeks, were divided into control group, low dose chemotherapy group, high dose chemotherapy group, HIFU group and HIFU combined chemotherapy group. The growth of mice tumor volume was observed in two weeks, by which we counted tumor volume doubling time and performed the growth curve. All specimens were analysed histologically.


RESULTS
HIFU combined mitomycin has significant synergistic inhibition effect. Tumor tissue damage such as huge coagulation necrosis was observed using light microscopy. However, there were still some remaining alive cells. The apoptosis of tumor cell in HIFU group and HIFU combined chemotherapy group obviously increased in comparison with other groups.


CONCLUSIONS
HIFU group, HIFU combined chemotherapy group can distinctively inhibit tumor growth; HIFU combined with mitomycin has notable synergistic inhibitory effect. HIFU may induce the apoptosis of tumor cell.
Wang
Guo-min
GM
Department of Urology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Yang
Yuan-feng
YF
Sun
Li-an
LA
Xu
Zhi-bing
ZB
Xu
Ye-qing
YQ
D000818:Animals; D017209:Apoptosis; D003131:Combined Modality Therapy; D005260:Female; D008297:Male; D051379:Mice; D016685:Mitomycin / Q000627:therapeutic use*; D014464:Ultrasonic Therapy; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000628:therapy*
D016685:Mitomycin