Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy.
We demonstrate the clinical application of a multiplanar imaging system that simultaneously acquires en face (C-scan) optical coherence tomography (OCT) and the corresponding confocal ophthalmoscopic images, along with cross-sectional (B-scan) OCT at specifiable locations on the confocal image. The advantages of the simultaneous OCT and confocal acquisition as well as the challenges of interpreting the C-scan OCT images are discussed. Variations in tissue inclination with respect to the coherence wave surface alter the sampling of structures within the depth of the retina, producing novel slice orientations that are often challenging to interpret. We have evaluated for the first time the utility of C-scan OCT for a variety of pathologies, including melanocytoma, diabetic retinopathy, choroidal neovascular membrane, and macular pucker. Several remarkable new aspects of clinical anatomy were revealed using this new technique. The versatility of selective capture of C-scan OCT images and B-scan OCT images at precise points on the confocal image affords the clinician a more complete and interactive tool for 3-D imaging of retinal pathology.
Podoleanu
Adrian Gh
AG
School of Physical Sciences, Applied Optics Group, University of Kent, Canterbury, United Kingdom. ap11@ukc.ac.uk
Dobre
George M
GM
Cucu
Radu G
RG
Rosen
Richard
R
Garcia
Patricia
P
Nieto
Juan
J
Will
Daniel
D
Gentile
Ronald
R
Muldoon
Thomas
T
Walsh
Joseph
J
Yannuzzi
Lawrence A
LA
Fisher
Yale
Y
Orlock
Dennis
D
Weitz
Rishard
R
Rogers
John A
JA
Dunne
Shane
S
Boxer
Aaron
A
D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000295:instrumentation / Q000379:methods; D018613:Microscopy, Confocal / Q000295:instrumentation* / Q000379:methods*; D019721:Ophthalmoscopes; D009887:Ophthalmoscopy / Q000379:methods*; D010865:Pilot Projects; D012160:Retina / Q000473:pathology*; D012164:Retinal Diseases / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods*