title: Role of matrix metalloproteinases in vascular remodeling.
abstract: Vascular remodeling, defined as lasting structural changes in the vessel wall in response to hemodynamic stimuli, plays a role in many (patho)physiological processes requiring cell migration and degradation of extracellular matrix(ECM). Matrix metalloproteinase(MMP) system can degrade most ECM components. Several lines of evidence support a role for MMP system components in the development and progression of atherosclerosis and restenosis after angioplasty. This review article focuses on the role of MMPs in vascular remodeling relevant to atherosclerosis and restenosis after angioplasty.
authors.affiliation: Department of Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan. kuzuya@med.nagoya-u.ac.jp
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kuzuya
authors.forename: Akihisa
authors.initials: A
authors.lastname: Iguchi
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism / Q000503:physiopathology*; D005109:Extracellular Matrix / Q000378:metabolism*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000201:enzymology / Q000503:physiopathology*
chemical_list: D020782:Matrix Metalloproteinases