Stereoselective diversity-oriented solution and solid-phase synthesis of tetrahydroquinoline-based polycyclic derivatives.
A diversity-oriented solution and solid-phase synthesis of tetrahydroquinoline-based tricyclic derivatives has been achieved from enantiomerically pure, natural product-like bicyclic scaffold. The solution synthesis of enantiopure bicyclic scaffold was developed by asymmetric hetero Michael reaction. Our approach for the synthesis of polycyclic derivatives utilized regio- and stereoselective hetero Michael reaction and ring-closing metathesis as key steps in solution and on solid phase.
Arya
Prabhat
P
Chemical Biology Program, Steacie Institute for Molecular Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada, K1A 0R6. Prabhat.Arya@nrc.ca
Durieux
Patricia
P
Chen
Zai-Xin
ZX
Joseph
Reni
R
Leek
Donald M
DM
D001894:Borohydrides; D007202:Indicators and Reagents; D018020:Lithium Compounds; D009682:Magnetic Resonance Spectroscopy; D011083:Polycyclic Compounds / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*; D012996:Solutions; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism
D001894:Borohydrides; D007202:Indicators and Reagents; D018020:Lithium Compounds; D011083:Polycyclic Compounds; D011804:Quinolines; D012996:Solutions; C040936:lithium borohydride