title: Sudden death in growth hormone-treated children with Prader-Willi syndrome.
abstract: A 4-year-old boy with Prader-Willi syndrome died suddenly while asleep on day 67 of growth hormone treatment. During treatment, snoring had worsened. Autopsy showed multifocal bronchopneumonia. This case and two others recently published suggest that growth hormone may be associated with obstructive apnea, respiratory infection, and sudden death in this condition.
authors.affiliation: Departments of Pediatrics and Pathology, Sainte-Justine Hospital and Research Center, University of Montreal, Quebec, Canada. gvanvliet@justine.umontreal.ca
authors.forename: Guy
authors.initials: G
authors.lastname: Van Vliet
authors.forename: Cheri L
authors.initials: CL
authors.lastname: Deal
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Crock
authors.forename: Yves
authors.initials: Y
authors.lastname: Robitaille
authors.forename: Luc L
authors.initials: LL
authors.lastname: Oligny
mesh_terms: D001996:Bronchopneumonia / Q000139:chemically induced*; D002675:Child, Preschool; D000075202:Contraindications; D003645:Death, Sudden / Q000209:etiology*; D017809:Fatal Outcome; D019382:Human Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011218:Prader-Willi Syndrome / Q000188:drug therapy*
chemical_list: D019382:Human Growth Hormone