Subacute infective endocarditis caused by Corynebacterium diphtheriae: a case report.
The authors report an 11-year-old boy with septicemia and subacute infective endocarditis due to toxigenic-Corynebacterium diphtheriae. The patient had underlying congenital heart disease and incomplete immunization. He presented with fever, epistaxis and congestive heart failure. He received high-dose penicillin therapy and diphtheria antitoxin with clinical improvement. While he was receiving a high dose of penicillin for 1 month he developed a generalized tonic clonic seizure. A computerized tomogram revealed intracerebral and ventricular hemorrhage. Craniotomy with blood clot removal and ventriculostomy drainage were done. He died 2 days later from brain death and cardiovascular failure.
Lolekha
Rangsima
R
Infectious Disease Unit, Queen Sirikit National Institute of Child Health, Bangkok, 10400, Thailand.
Supradish
Praon
P
Kirawittaya
Tawatchai
T
Srimaharaja
Saksan
S
Chotpitayasunondh
Tawee
T
D002648:Child; D003353:Corynebacterium diphtheriae / Q000302:isolation & purification*; D004165:Diphtheria / Q000209:etiology* / Q000473:pathology; D004697:Endocarditis, Bacterial / Q000382:microbiology* / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008297:Male