Type 2 diabetes: treat to target.
Traditionally, practitioners have reserved insulin therapy for patients with type 2 diabetes until diet, exercise, and treatment with oral agents have failed to maintain glycemic control. Increasing evidence, however, supports advancing insulin therapy earlier in treating diabetes, not only to normalize glycemic control and emulate normal physiologic insulin secretion, but also to delay or prevent disease-associated comorbidity.
Funnell
Martha M
MM
Michigan Diabetes Research and Training Center, Ann Arbor, Mich, USA.
Kruger
Davida F
DF
D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy*; D018450:Disease Progression; D004334:Drug Administration Schedule; D016903:Drug Monitoring / Q000379:methods*; D004359:Drug Therapy, Combination; D006801:Humans; D007328:Insulin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic; D013453:Sulfonylurea Compounds / Q000627:therapeutic use
D001786:Blood Glucose; D007328:Insulin; D013453:Sulfonylurea Compounds