Disruption of self-organized actions in monkeys with progressive MPTP-induced parkinsonism: II. Effects of reward preference.
The motor and cognitive symptoms of Parkinson's disease (PD) are well documented, but little is known about the functionality of motivational processes mediated by the limbic circuits of basal ganglia. The aim of this study was to test the ability of motivational processes to direct and to urge behaviour, in four vervet monkeys (Cercopithecus aethiops) progressively intoxicated with systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injections (0.3-0.4 mg/kg every 4-7 days). In the food preference task, the monkeys had to retrieve two types of directly visible food, simultaneously available in the wells of a reward board. At all stages of MPTP-induced parkinsonism, the monkeys continued to take their favourite food first. In the symbol discrimination task, the wells were covered with sliding plaques cued by symbols indicating the absence or presence of a reward, and the different types of food were blocked in separate sessions. Monkeys with mild or moderate parkinsonism made fewer attempts and took longer to retrieve non-preferred compared with preferred rewards. These results indicate that motivational processes are still able to direct (food preference task) and to urge (symbol discrimination task) behaviour in MPTP-lesioned monkeys. Such a functional preservation may be related to the relatively spared dopaminergic innervation of the limbic circuits that we found in our monkeys, in agreement with the literature on humans. Furthermore, the frequency of executive disorders (such as hesitations and freezing) appeared to be much lower with the preferred rewards. Thus, the preserved motivational processes may help to overcome executive dysfunction in the early stages of human PD.
Pessiglione
Mathias
M
Neurologie et Thérapeutique expérimentale (INSERM U289), Hôpital de la Salpêtrière, Paris, France.
Guehl
Dominique
D
Jan
Caroline
C
François
Chantal
C
Hirsch
Etienne C
EC
Féger
Jean
J
Tremblay
Léon
L
D000818:Animals; D002522:Chlorocebus aethiops; D002755:Choice Behavior / Q000502:physiology*; D005518:Food Preferences / Q000502:physiology* / Q000523:psychology; D020267:MPTP Poisoning / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008636:Mesencephalon / Q000473:pathology / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D012201:Reward