Improvement of intestinal motility using S-methylisothiourea in postoperative ileus.
BACKGROUND
The inflammatory mediator nitric oxide (NO) plays an important role in postoperative gastrointestinal motility.


METHODS
Using S-methylisothiourea sulfate (SMT), a selective inducible nitric oxide synthase inhibitor, we studied the physiological role of the endogenous NO in the modulation of intestinal motility. The study was performed in vivo in a canine postoperative model. Ten mongrel dogs were treated with a continuous intravenous infusion of SMT after a surgical intestinal manipulation. Small intestine transit time was fluoroscopically measured using barium sulfate as it passed through a gastrostomy tube on postoperative days (POD) 1, 2, and 3.


RESULTS
Average transit times on POD 1 in the 4 mg/kg/h and 2 mg/kg/h SMT groups significantly decreased compared with that of the saline group. However, the transit times on POD 2 and 3 were not significantly different among the three groups.


CONCLUSIONS
S-methylisothiourea sulfate improves small intestine motility at an early postoperative stage.
Uenoyama
Shouiti
S
First Department of Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan. sue@hama-med.ac.jp
Kobayashi
Toshihiko
T
Takeuchi
Yutaka
Y
Yamashita
Kimihiro
K
Koide
Yukio
Y
Kazui
Teruhisa
T
D000818:Animals; D004285:Dogs; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D045823:Ileus / Q000209:etiology*; D007550:Isothiuronium / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy*
D004791:Enzyme Inhibitors; D007550:Isothiuronium; C027744:S-methylisothiopseudouronium