title: Chemotherapy for newly diagnosed and relapsed advanced ovarian cancer.
abstract: OBJECTIVE
  To review chemotherapy options for patients with newly diagnosed or relapsed advanced ovarian cancer.
  
  
  METHODS
  Published literature.
  
  
  CONCLUSIONS
  Primary chemotherapy for newly diagnosed, advanced ovarian cancer consisting of a platinum compound and a taxane is commonly associated with myelosuppression, nausea/vomiting, alopecia, and sensory/motor neuropathy. For recurrent disease, numerous chemotherapy agents are effective, including rechallenging the patient with a platinum and/or a taxane or using newer agents such as pegylated liposomal doxorubicin, topotecan, and gemcitabine. In platinum-resistant disease, selection is based mainly on the toxicity profile, because palliation and quality of life are important.
  
  
  CONCLUSIONS
  Oncology nurses play a valuable role in ovarian cancer care by proactively meeting patient information needs.
authors.affiliation: MetroHealth Medical Center, Cancer Care Pavilion, Room 2017, 2500 MetroHealth Dr, Cleveland, OH 44109, USA.
authors.forename: Peter G
authors.initials: PG
authors.lastname: Rose
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000451:nursing; D024802:Nurse's Role; D015404:Nursing Methodology Research; D009859:Oncology Nursing / Q000592:standards*; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000451:nursing
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D000972:Antineoplastic Agents, Phytogenic; D009944:Organoplatinum Compounds