Endothelin and vascular function in liver disease.
The endothelins are a group of three related peptides with two receptor subtypes, ET(A) and ET(B). Following the discovery of endothelin 1 as a potent vasoconstrictor, there has been intense interest in the role of endothelin on vascular function in liver disease. Speculation on the role of endothelin in the pathogenesis of acute renal failure, including hepatorenal syndrome, has also been speculated.
Moore
K
K
Centre for Hepatology, Royal Free and University College Medical School, University College London, Rowland Hill Street, London NW3 2PF, UK. kmoore@rfc.ucl.ac.uk
D000818:Animals; D016232:Endothelins / Q000502:physiology*; D006530:Hepatorenal Syndrome / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D008103:Liver Cirrhosis / Q000378:metabolism* / Q000503:physiopathology; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D017082:Portal Pressure; D051381:Rats; D044022:Receptor, Endothelin A / Q000378:metabolism; D044023:Receptor, Endothelin B / Q000378:metabolism
D016232:Endothelins; D044022:Receptor, Endothelin A; D044023:Receptor, Endothelin B