Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage.
Macrophage inhibitory cytokine 1 (MIC 1) is thought to have immunomodulatory actions favouring fetal viability. We measured serum concentrations of MIC 1 in asymptomatic women at 6-13 weeks' gestation who subsequently miscarried or who had already miscarried. MIC 1 concentrations in the miscarriage cohort (n=100), were a third of those who had ongoing pregnancies (n=197). Multiples of the median for miscarriage was 0.32 (95% CI 0.23-0.32) versus 1.00 (0.93-1.06) for ongoing pregnancies; p<0.0001. Concentrations were just as low 3 weeks before diagnosis as on the day of diagnosis. That MIC 1 serum concentrations seem to be low weeks before miscarriage suggests possible predictive and causative roles, as well as therapeutic potential.
Tong
Stephen
S
Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, Clayton 3168, Victoria, Australia.
Marjono
Budi
B
Brown
David A
DA
Mulvey
Sheila
S
Breit
Samuel N
SN
Manuelpillai
Ursula
U
Wallace
Euan M
EM
D000022:Abortion, Spontaneous / Q000097:blood / Q000175:diagnosis* / Q000517:prevention & control; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood* / Q000502:physiology; D005260:Female; D005328:Fetal Viability / Q000502:physiology; D005865:Gestational Age; D055436:Growth Differentiation Factor 15; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First
D015415:Biomarkers; D016207:Cytokines; C526140:GDF15 protein, human; D055436:Growth Differentiation Factor 15