Evaluation of the antioxidant activity of new carotenoid-like compounds by electron paramagnetic resonance.
The antioxidant activity of a novel series of derivatives with a carotenoid-like structure was studied. These derivatives have recently been isolated chemically as a result of studies on the pigments present in a particular species of birds, namely parrots. These novel derivatives, which are also called parrodienes, have been proved to possess interesting biological properties that differ from those that carotenoids are known to have. The objective of this study was to demonstrate the ability of these novel compounds to inhibit the formation of reactive oxygen species, especially their ability to block the formation of hydroxyl radicals, which are among the most reactive products of oxygen reactions and which produce the greatest damage to cells and tissues. The technique used to assess this antioxidant capacity of parrodienes was electron paramagnetic resonance, which allows direct assessment of inhibition of hydroxyl radical formation (.OH). The results show that these derivatives, especially octatriene, are able to exert evident antioxidant activity, thus confirming that their antioxidant properties are important for their biological activity.
Morelli
R
R
Consiglio Nazionale delle Ricerche (CNR), Institute of Sciences and Molecular Technologies, Milan, Italy.
Loscalzo
R
R
Stradi
R
R
Bertelli
A
A
Falchi
M
M
D000447:Aldehydes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D002338:Carotenoids / Q000378:metabolism / Q000494:pharmacology*; D003497:Cyclic N-Oxides / Q000737:chemistry / Q000378:metabolism; D003505:Cyclodextrins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods*; D016166:Free Radical Scavengers / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D006861:Hydrogen Peroxide; D017665:Hydroxyl Radical / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D007501:Iron; D010311:Parrots; D011090:Polyenes / Q000378:metabolism / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism
C489161:2,4,6-octatrienal; D000447:Aldehydes; D000975:Antioxidants; D003497:Cyclic N-Oxides; D003505:Cyclodextrins; C045076:Fenton's reagent; D016166:Free Radical Scavengers; D011090:Polyenes; D017382:Reactive Oxygen Species; D017665:Hydroxyl Radical; D002338:Carotenoids; C017245:5,5-dimethyl-1-pyrroline-1-oxide; D006861:Hydrogen Peroxide; D007501:Iron