Association of angiotensin converting enzyme gene I/D polymorphism of vitiligo in Korean population.
Vitiligo (leukoderma) is an acquired idiopathic hypomelanotic disorder characterized by the circumscribed depigmented patches. Vitiligo is a polygenic disease. The exact pathogenesis is not yet known. The angiotensin converting enzyme (ACE) gene was selected as a candidate gene as ACE plays an important role in the physiology of the vasculature, blood pressure and inflammation, and its relationship with various diseases, including autoimmune diseases, has been widely investigated. The I/D polymorphism of ACE gene in vitiligo patients has not been reported. In this study, we investigated ACE gene polymorphism in 120 vitiligo patients and in 429 healthy volunteers in Korea. The ACE gene genotype distribution (P = 0.032) and allele frequency (P = 0.012) were significantly different between vitiligo patients and healthy controls. This study suggests that the ACE gene polymorphism has a strong association with the development of vitiligo in Korean patients.
Jin
Sheng-Yu
SY
Department of Pharmacology, Kohwang Medical Research Institute, College of Medicine, Kyung Hee University, Seoul, Korea.
Park
Hyun-Ho
HH
Li
Guang-Zhe
GZ
Lee
Hee-Jae
HJ
Hong
Mee-Suk
MS
Hong
Seung-Jae
SJ
Park
Hun-Kuk
HK
Chung
Joo-Ho
JH
Lee
Mu-Hyoung
MH
D000328:Adult; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D007723:Korea; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D014820:Vitiligo / Q000209:etiology / Q000235:genetics*
D007703:Peptidyl-Dipeptidase A