Short-term effects of an intensive lifestyle modification program on lipid peroxidation and antioxidant systems in patients with coronary artery disease.
The purpose of this study was to compare the short-term effects of an intensive lifestyle modification (ILM) program on lipid peroxidation and antioxidant systems in patients with coronary artery disease (CAD). Twenty-two patients in the control group continued to receive their conventional treatment with lipid-lowering drugs, whereas 22 patients in the experimental group were assigned to intensive lifestyle modification (ILM) without taking any lipid-lowering agent. The ILM program comprised dietary advice on low-fat diets, high antioxidants and high fiber intakes, yoga exercise, stress management and smoking cessation. After 4 months of intervention, patients in the experimental group revealed a statistically significant increase in plasma total antioxidants, plasma vitamin E and erythrocyte glutathione (GSH) compared to patients in the control group. There was no significant change in plasma malondialdehyde (MDA), a circulating product of lipid peroxidation, in either group. We concluded that the ILM program increased circulating antioxidants and reduced oxidative stress in patients with CAD.
Jatuporn
Srisakul
S
Department of Biochemistry, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. srisakul.j@chula.ac.th
Sangwatanaroj
Somkiat
S
Saengsiri
Aem-Orn
AO
Rattanapruks
Sopida
S
Srimahachota
Suphot
S
Uthayachalerm
Wasan
W
Kuanoon
Wanpen
W
Panpakdee
Orasa
O
Tangkijvanich
Pisit
P
Tosukhowong
Piyaratana
P
D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use; D003327:Coronary Disease / Q000097:blood / Q000178:diet therapy / Q000628:therapy*; D018752:Diet, Fat-Restricted; D004043:Dietary Fiber / Q000627:therapeutic use; D005081:Exercise Therapy; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D019018:Imagery, Psychotherapy; D008019:Life Style; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D012064:Relaxation Therapy; D016540:Smoking Cessation; D013315:Stress, Psychological / Q000628:therapy; D014810:Vitamin E / Q000627:therapeutic use; D015013:Yoga
D000975:Antioxidants; D004043:Dietary Fiber; D008055:Lipids; D014810:Vitamin E; D008315:Malondialdehyde; D005978:Glutathione; D001205:Ascorbic Acid