[Adrenergic receptor signaling and regulation].
At the beginning, beta-arrestin is believed to regulate desensitization of G protein-coupled receptors. However, it becomes apparent that beta-arrestin is involved in not only regulation but also signal transduction by identification of many proteins interacting with beta-arrestin. So far, the model of regulation and signaling of G protein-coupled receptor is built on beta 2-adrenergic receptor. However, this model does not apply to all G protein-coupled receptors. The differential regulation and signaling between beta 1- and beta 2-adrenergic receptors is presented.
Kurose
Hitoshi
H
Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
D019393:Arrestin / Q000502:physiology*; D006801:Humans; D011941:Receptors, Adrenergic / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D019393:Arrestin; D011941:Receptors, Adrenergic