title: Decreased adrenomedullin and total nitrite levels in breast milk of preeclamptic women.
abstract: OBJECTIVE
  To observe the adrenomedullin (AM) and total nitrite levels in the milk of preeclamptic and normal pregnant women.
  
  
  METHODS
  Fifteen women with preeclampsia and 15 normal pregnant women were included in the study. Total nitrite was quantitated by Griess reaction, while AM was measured by HPLC.
  
  
  RESULTS
  The levels of AM and total nitrite in colostrum and 30th-day breast milk were decreased in preeclamptics. Total nitrite levels (micromol/l) were 56.09 +/- 11.18 vs. 82.20 +/- 12.01, P < 0.05, in colostrum of preeclamptics and controls, respectively. The level of total nitrite was 37.75 +/- 12.10 vs. 53.28 +/- 10.25, P < 0.05, in 30th-day milk of same patients. AM levels (pg/ml) were 11.18 +/- 1.11 vs. 16.59 +/- 1.24, P < 0.0001, in colostrum of preeclamptics and controls, respectively. In 30th-day milk of same patients, AM levels were 8.41 +/- 1.39 vs. 12.18 +/- 1.48, P < 0.005, respectively.
  
  
  CONCLUSIONS
  This report shows for the first time that human milk has decreased levels of AM and total nitrite in preeclampsia.
authors.affiliation: Department of Biochemistry, Medical Faculty, Kocaeli University, Izmit, Turkey. mustafacekmen@hotmail.com
authors.forename: Mustafa Baki
authors.initials: MB
authors.lastname: Cekmen
authors.forename: Ayse
authors.initials: A
authors.lastname: Balat
authors.forename: Ozcan
authors.initials: O
authors.lastname: Balat
authors.forename: Fuat
authors.initials: F
authors.lastname: Aksoy
authors.forename: Muhittin
authors.initials: M
authors.lastname: Yurekli
authors.forename: Ayse Binnur
authors.initials: AB
authors.lastname: Erbagci
authors.forename: Saime
authors.initials: S
authors.lastname: Sahinoz
mesh_terms: D053607:Adrenomedullin; D005260:Female; D006801:Humans; D008895:Milk, Human / Q000737:chemistry / Q000378:metabolism*; D009573:Nitrites / Q000737:chemistry / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy; D014421:Turkey
chemical_list: D009573:Nitrites; D010455:Peptides; D053607:Adrenomedullin