Acute lymphocytic leukemia in a child with Beckwith-Wiedemann syndrome.
Beckwith-Wiedemann syndrome (BWS) is an overgrowth syndrome characterized by neonatal hypoglycemia, abdominal wall defects, macroglossia, organomegaly, ear pits and creases, hemihypertrophy, and increased birthweight. Children with BWS have an increased risk of malignancy. The authors present the case of a 3-year-old boy diagnosed with both BWS and acute lymphocytic leukemia (ALL). This case report will elaborate on the possibilities as to how BWS and ALL may be associated due to abnormal genomic imprinting and IGF dysregulation.
Khatib
Ziad
Z
Division of Hematology Oncology, Department of Pediatrics, Miami Children's Hospital, Miami, Florida, USA. ziad.khatib@mch.com
Levi
Alejandro
A
Pefkarou
Athena
A
Escalon
Enrique
E
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001506:Beckwith-Wiedemann Syndrome / Q000150:complications / Q000188:drug therapy / Q000209:etiology*; D002675:Child, Preschool; D018392:Genomic Imprinting; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics; D007335:Insulin-Like Growth Factor II / Q000235:genetics; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy / Q000209:etiology*; D012074:Remission Induction / Q000379:methods
D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II