Polymorphisms of GSTT1 and related genes in head and neck cancer risk.
BACKGROUND
Glutathione S-transferase T1 detoxifies some environmental carcinogens while activating others and is deleted in 15% to 38% of humans. We sought to determine whether GSTT1 genotype and genotypes of several related genes are associated with risk of squamous cell carcinoma of the head and neck (HNSCC).


METHODS
Somatic genotypes for GSTT1, GSTM1, GSTP1, and CYP1A1 were determined in 283 individuals with HNSCC and 208 population-based controls.


RESULTS
The OR for presence of GSTT1 was 1.6 (CI, 1.1-2.5, p = 0.03). HNSCC risk was not associated with GSTM1 null genotype, the presence of the GSTP1 Val/Val genotype, or the Val/Val homozygous genotype for CYP1A1. Stratified analysis revealed disparate ORs for women (OR, 3.0; CI, 1.5-6.3) and men (OR, 1.2; CI, 0.7-2.1) for the presence of GSTT1.


CONCLUSIONS
In this population, the presence of GSTT1 gene was associated with a significant increase in the risk of HNSCC. This association was particularly robust in women.
Evans
Adam J
AJ
Division of Hematology and Medical Oncology, Oregon Health and Science University, Mail Code L586, Portland, Oregon 97201, USA.
Henner
William David
WD
Eilers
Kristi M
KM
Montalto
Michelle A
MA
Wersinger
Emily M
EM
Andersen
Peter E
PE
Cohen
James I
JI
Everts
Edwin C
EC
McWilliams
Jeffrey E
JE
Beer
Tomasz M
TM
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology; D044465:White People / Q000235:genetics
C413545:glutathione S-transferase T1; D005982:Glutathione Transferase