title: Multispectral imaging of tablets in blister packaging.
abstract: This experiment tested the hypothesis that using near-infrared (IR) imaging spectrometry on tablets through blister packs permits the identification and composition of multiple individual tablets to be determined simultaneously. Aspirin was selected for this study because its breakdown mechanism is well understood. Near-IR cameras were used to collect thousands of spectra simultaneously from a field of packaged aspirin tablets. Tablets were selected by a principal component analysis selection algorithm. Graphs of the columns of the transformation matrix showed that salicylic acid and acetylsalicylic acid in the samples were modeled by the principal components. The bootstrap error-adjusted single-sample technique chemometric-imaging algorithm was used to draw probability-density contour plots that revealed tablet composition. Choice of color was used to represent constituent identity, whereas intensity represented concentration. The percentage of usable pixels in the indium antimonide (InSb) array was 99.9%. The SEP was 0.06% of the tablet mass for both water uptake and salicylic acid production. The number of tablets that a typical near-IR camera can currently analyze simultaneously was also estimated to be approximately 1300.
authors.affiliation: Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky Medical Center, Lexington, KY 40536-0082, USA.
authors.forename: I
authors.initials: I
authors.lastname: Malik
authors.forename: M
authors.initials: M
authors.lastname: Poonacha
authors.forename: J
authors.initials: J
authors.lastname: Moses
authors.forename: R A
authors.initials: RA
authors.lastname: Lodder
mesh_terms: D001241:Aspirin / Q000737:chemistry*; D004349:Drug Packaging; D004355:Drug Stability; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013607:Tablets
chemical_list: D013607:Tablets; D001241:Aspirin