title: Clinical evaluation of an HP-guar gellable lubricant eye drop for the relief of dryness of the eye.
abstract: OBJECTIVE
  To evaluate the efficacy of a new lubricant eye drop containing polyethylene glycol 400 and propylene glycol demulcents with hydroxypropyl-guar as a gelling agent (Test Product) to a system with carboxymethylcellulose (Control Product) for reducing dry eye signs and symptoms.
  
  
  METHODS
  Eighty-seven dry eye volunteers were enrolled at seven sites for this six-week, concurrently controlled, double-masked clinical study.
  
  
  RESULTS
  The Test Product significantly reduced conjunctival staining (p = 0.025) and temporal corneal staining (p = 0.024) compared to the Control. The Test Product also significantly reduced symptoms of dryness in the morning and evening, compared to the Control (p = 0.015 and p = 0.023, respectively). Subjects in the Test treatment group reported lower frequencies of foreign body sensation and felt their eyes were "refreshed longer" compared to those in the Control group (p = 0.033 and p = 0.037, respectively).
  
  
  CONCLUSIONS
  The Test Product was more effective at reducing both the signs and symptoms of dry eye compared to the carboxymethylcellulose containing Control.
authors.affiliation: Alcon Labs, Consumer Products, Fort Worth, TX, USA. mike.christensen@alconlabs.com
authors.forename: Mike T
authors.initials: MT
authors.lastname: Christensen
authors.forename: Steven
authors.initials: S
authors.lastname: Cohen
authors.forename: John
authors.initials: J
authors.lastname: Rinehart
authors.forename: Frank
authors.initials: F
authors.lastname: Akers
authors.forename: Bart
authors.initials: B
authors.lastname: Pemberton
authors.forename: Marc
authors.initials: M
authors.lastname: Bloomenstein
authors.forename: Mark
authors.initials: M
authors.lastname: Lesher
authors.forename: David
authors.initials: D
authors.lastname: Kaplan
authors.forename: David
authors.initials: D
authors.lastname: Meadows
authors.forename: Patricia
authors.initials: P
authors.lastname: Meuse
authors.forename: Charles
authors.initials: C
authors.lastname: Hearn
authors.forename: Jerry M
authors.initials: JM
authors.lastname: Stein
mesh_terms: D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage; D003228:Conjunctiva / Q000187:drug effects / Q000473:pathology; D003315:Cornea / Q000187:drug effects / Q000473:pathology; D004311:Double-Blind Method; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D015352:Dry Eye Syndromes / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005685:Galactans; D005782:Gels; D006801:Humans; D008153:Lubrication; D008297:Male; D008351:Mannans; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D053149:Plant Gums; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D011310:Preservatives, Pharmaceutical; D019946:Propylene Glycol / Q000008:administration & dosage*; D012449:Safety; D016896:Treatment Outcome
chemical_list: D005685:Galactans; D005782:Gels; D008351:Mannans; D009883:Ophthalmic Solutions; D053149:Plant Gums; D011310:Preservatives, Pharmaceutical; D011092:Polyethylene Glycols; D019946:Propylene Glycol; C007894:guar gum; D002266:Carboxymethylcellulose Sodium