Hepatic fibrosis and survival in biliary atresia.
In biliary atresia, progression of hepatic fibrosis before the Kasai portoenterostomy may explain why age is a major determinant of survival of the native liver. Blinded fibrosis scoring of surgical liver biopsies demonstrated that age and fibrosis correlate. Those biopsies with severe fibrosis predicted significantly worse survival.
Weerasooriya
Viraine S
VS
Departments of Pediatrics and Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA.
White
Frances V
FV
Shepherd
Ross W
RW
D001656:Biliary Atresia / Q000150:complications / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007223:Infant; D008103:Liver Cirrhosis / Q000150:complications* / Q000473:pathology; D008297:Male; D011171:Portoenterostomy, Hepatic; D012189:Retrospective Studies; D016019:Survival Analysis