Functions of pRb and p53: what's the connection?
The pRb and p53 proteins have tumour suppressor functions and both are regulators of transcription. Their mechanisms of transcriptional regulation are unrelated in many ways--in contrast, it would appear, to their biological functions. This review highlights their biological connections in the light of recent advances in understanding the mechanisms of pRb and p53 function.
Kouzarides
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Wellcome/CRC Institute and the Dept of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QR, UK.