title: [Functional difference of prokinetics depending on subtypes and localization of receptor in alimentary tract].
abstract: Interaction of function and localization of receptors, especially the 5-hydroxytryptamine4 (5-HT4) receptor was examined in relation to the motility of gastrointestinal tract. The responses mediated by stimulation of 5-HT4 receptor appear to differ with different localization of receptor. The 5-HT4 receptor-mediated acceleration of acetylcholine (ACh) release in the preparations isolated from gastric antrum and corpus, but not fundus, of guinea pig corresponded to the presence of 5-HT4 receptor in the myenteric plexus. The 5-HT4 receptor-mediated response was predominant in the 5-HT-induced acceleration of motility associated with ACh release in the intestine of the whole body of dogs, and the 5-HT4 receptor was localized on the myenteric plexus of dog intestine. Local administration of GABA into intestinal marginal artery reduced the motility associated with ACh release in the intestine of whole body of dogs, and thus response via the inhibitory GABAB receptor was more predominant than that via excitatory GABAA receptor. The GABAB receptor is the first G protein-coupled receptor discovered to form heterodimers, consisted of GABAB1 and GABAB2. There are isoforms of GABAB1, from GABAB1(a) to GABAB1(g), and therefore the function and localization of the GABAB receptor may vary with the different isoforms of GABAB1.
authors.affiliation: Division of Pharmacology, Department of Translational Research, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan.
authors.forename: Kohtaro
authors.initials: K
authors.lastname: Taniyama
authors.forename: Muneshige
authors.initials: M
authors.lastname: Kaibara
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Uezono
authors.forename: Hideki
authors.initials: H
authors.lastname: Hayashi
mesh_terms: D000818:Animals; D004285:Dogs; D005769:Gastrointestinal Motility / Q000502:physiology*; D006168:Guinea Pigs; D006801:Humans; D009197:Myenteric Plexus / Q000502:physiology; D051381:Rats; D018079:Receptors, GABA / Q000502:physiology*; D011985:Receptors, Serotonin / Q000502:physiology*
chemical_list: D018079:Receptors, GABA; D011985:Receptors, Serotonin