title: Experimental study on cheng zai wan for treatment of necrosis of the femoral head.
abstract: Cheng Zai Wan ([symbol: see text]), a Chinese herbal preparation was administrated in the two-leg rat model of aseptic necrosis of the femoral head established by taking prednisone acetate for a long period and the osteoporosis model rat by castration in order to explore the effects of the prescription on necrosis of the femoral head. The results showed that after treatment, the pitting on the surface of the femoral head disappeared, the reticular structure with filling cells was restored; the fat droplets in bone cells or cartilage cells of the femoral head were significantly reduced; sparse capillaries were improved, density and width of the bone trabecula were increased somewhat; bone mineral density, bone weight, bone strength and rigidity were significantly increased; and the low level of estrin was improved. It is suggested that Cheng Zai Wan has definite therapeutic effects on aseptic necrosis of the femoral head.
authors.affiliation: Institute of Orthopedics and Traumatology, China Academy of Traditional Chinese Medicine, Beijing 1000700.
authors.forename: Yanping
authors.initials: Y
authors.lastname: Chen
authors.forename: Keqin
authors.initials: K
authors.lastname: Huang
authors.forename: Fengping
authors.initials: F
authors.lastname: Lang
authors.forename: Yongxun
authors.initials: Y
authors.lastname: Huang
authors.forename: Hui
authors.initials: H
authors.lastname: Huang
authors.forename: Hong
authors.initials: H
authors.lastname: Huang
authors.forename: Chongguang
authors.initials: C
authors.lastname: Zhou
authors.forename: Wanqiang
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005270:Femur Head / Q000473:pathology; D005271:Femur Head Necrosis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D010024:Osteoporosis / Q000188:drug therapy / Q000473:pathology; D008517:Phytotherapy; D011241:Prednisone; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D011241:Prednisone