Clinical utility and approach to estimate postprandial hypertriglycemia by a newly designed oral fat-loading test.
The objective of this study was to estimate postprandial hypertriglycemia by a newly designed oral fat-loading test. Twenty-three healthy normolipidemic volunteers were orally administered a test meal consisting of a mixture of Telmeal 2.0 and 20 g of salt-free butter after fasting for 12 h. To measure the levels of total cholesterol (T-Cho), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), remnant-like particle-cholesterol (RLP-C), lipoprotein (a) [Lp (a)], free fatty acid, apolipoproteins (Apos), plasma glucose (PG), immunoreactive insulin (IRI), and high-sensitivity C-reactive protein (hs-CRP), venous blood samples were collected before the meal and at each hour until 9 h after fat-loading. The levels of both TG and RLP-C were drastically elevated at 2 h after fat-loading and these levels remained high until 4 h (p < 0.01). A significant correlation between TG and RLP-C was also observed at 2, 3 and 4 h, and the values of the correlation coefficients (r) were 0.837, 0.838, and 0.908, respectively. In contrast, the levels of T-Cho, HDL-C, Lp (a), Apos, PG, and hs-CRP did not change. Furthermore, there were no gastrointestinal symptoms during or after the study. These results strongly suggested that this newly designed fat-loading test was very useful for evaluating postprandial hypertriglycemia, including remnant concentrations.
Igarashi
Masahiko
M
Department of Laboratory Medicine, Yamagata University School of Medicine, Yamagata, Japan. migarasi@med.id.yamagata-u.ac.jp
Hirata
Akihiko
A
Yamauchi
Toshiyuki
T
Yamaguchi
Hiroshi
H
Tsuchiya
Hiromi
H
Ohnuma
Hiroshi
H
Jimbu
Yumi
Y
Okuyama
Yoko
Y
Shirata
Toru
T
Otsu
Nobuhiro
N
Fukuyama
Haru
H
Takahashi
Sachiko
S
Tominaga
Makoto
M
Kato
Takeo
T
D000328:Adult; D001054:Apolipoproteins A / Q000097:blood; D001786:Blood Glucose; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000175:diagnosis*; D007328:Insulin / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D019518:Postprandial Period; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
D001054:Apolipoproteins A; D001786:Blood Glucose; D008076:Cholesterol, HDL; D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D017270:Lipoprotein(a); D008074:Lipoproteins; D014280:Triglycerides; C112017:remnant-like particle cholesterol; D002097:C-Reactive Protein; D002784:Cholesterol