Epidemiology of human papillomavirus infection and abnormal cytologic test results in an urban adolescent population.
We determined the prevalence of and the risk factors for human papillomavirus (HPV) infection and abnormal cytologic test results in 312 adolescent girls (mean age, 16.1 years). Subjects had a median of 2 years of sexual activity and 4 lifetime sex partners. Cervical HPV was detected by use of L1-consensus polymerase chain reaction in 64% of subjects; half of those with HPV had >1 type, and 77% had >/=1 high-risk type. Independent risk factors for HPV were lifetime number of sex partners, age of partner, and douching. Cytologic abnormalities were common (20.9% of subjects had atypical squamous cells of uncertain significance, and 17.0% had high- or low-grade squamous intraepithelial lesions) and were significantly associated with detection of HPV (P=.0001); however, most (51.6%) subjects with HPV had normal cytologic test results.
Tarkowski
Trudee A
TA
National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia, USA.
Koumans
Emilia H
EH
Sawyer
Mary
M
Pierce
Antonya
A
Black
Carolyn M
CM
Papp
John R
JR
Markowitz
Lauri
L
Unger
Elizabeth R
ER
D000293:Adolescent; D036022:Capsid Proteins; D005260:Female; D005838:Genotype; D005845:Georgia / Q000453:epidemiology; D006801:Humans; D015999:Multivariate Analysis; D009856:Oncogene Proteins, Viral / Q000032:analysis; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012307:Risk Factors; D012725:Sexual Behavior; D011795:Surveys and Questionnaires; D014505:Urban Population; D002577:Uterine Cervical Diseases / Q000453:epidemiology* / Q000821:virology; D014626:Vaginal Smears / Q000706:statistics & numerical data*
D036022:Capsid Proteins; D009856:Oncogene Proteins, Viral; C063317:L1 protein, Human papillomavirus type 16