Familial atrioventricular nodal reentry tachycardia.
Dual atrioventricular nodal pathways, the substrate responsible for atrioventricular node reentry tachycardia (AVNRT), are thought to be randomly occurring congenital anomalies. This article describes 14 patients in six families, each with two or three first-degree relatives with paroxysmal supraventricular tachycardia. Electrophysiological evidence of dual atrioventricular nodal pathways was established in all 13 patients studied, AVNRT was induced in 12 (92%), and radiofrequency ablation of the slow pathway was curative in all cases. The data suggest a hereditary contribution to the development of atrioventricular nodal pathways and AVNRT. The pattern of inheritance appears to be autosomal dominant.
Hayes
John J
JJ
Marshfield Clinic, University of Wisconsin Medical School, Marshfield, Wisconsin 54449, USA. hayes.john@marshfieldclinic.org
Sharma
Param P
PP
Smith
Peter N
PN
Vidaillet
Humberto J
HJ
D000293:Adolescent; D000328:Adult; D017115:Catheter Ablation; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000235:genetics* / Q000601:surgery