A Sod2 null mutation confers severely reduced adult life span in Drosophila.
A null mutation for the Sod2 gene, Sod2n283, was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodn283/Sodn283) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2-/- progeny suffer neonatal lethality. Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment.
Duttaroy
Atanu
A
Biology Department, Howard University, Washington, DC 20059, USA. aduttaroy@howard.edu
Paul
Anirban
A
Kundu
Mukta
M
Belton
Amy
A
D000818:Animals; D030801:Animals, Genetically Modified; D004331:Drosophila melanogaster / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D005260:Female; D005804:Genes, Lethal; D006540:Herbicides / Q000633:toxicity; D006720:Homozygote; D008017:Life Expectancy; D008297:Male; D009154:Mutation; D018384:Oxidative Stress; D010269:Paraquat / Q000633:toxicity; D010641:Phenotype; D013482:Superoxide Dismutase / Q000502:physiology*; D015996:Survival Rate
D006540:Herbicides; D013482:Superoxide Dismutase; D010269:Paraquat