title: Antipyretic effect of acetaminophen by inhibition of glutamate release after staphylococcal enterotoxin A fever in rabbits.
abstract: The present study was designed to determine whether the inhibition of glutamate release in organum vasculosum laminae terminalis (OVLT) of rabbit brain by acetaminophen might be protective in a whole-animal model of staphylococcal enterotoxin A (SEA) fever. Unanesthetized rabbits were administered intravenously with SEA, and both colonic temperature (Tco) and glutamate release in OVLT were measured simultaneously. The glutamate release in OVLT was measured with a microdialysis probe previously implanted. Both the Tco and glutamate release in OVLT were simultaneously increased following intravenous administration of SEA. The SEA-induced rise in both the Tco and the levels of glutamate release in OVLT were suppressed by pretreatment with intravenous injection of acetaminophen (1, 5 or 10 mg/kg). Furthermore, treatment of OVLT with acetaminophen (50-150 microg) attenuated the fever-like hyperthermia induced by intra-OVLT injection of glutamate. Our results show acetaminophen may reduce glutamate release in OVLT and result in antipyresis.
authors.affiliation: Department of Health Care Administration, Di Wan College of Management, Madou, Tainan 721, Taiwan.
authors.forename: Wu-Tein
authors.initials: WT
authors.lastname: Huang
authors.forename: Jhi-Joung
authors.initials: JJ
authors.lastname: Wang
authors.forename: Mao-Tsun
authors.initials: MT
authors.lastname: Lin
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions / Q000502:physiology; D004768:Enterotoxins; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D018698:Glutamic Acid / Q000378:metabolism* / Q000494:pharmacology; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011817:Rabbits
chemical_list: D018712:Analgesics, Non-Narcotic; D004768:Enterotoxins; D000082:Acetaminophen; C026066:enterotoxin A, Staphylococcal; D018698:Glutamic Acid