title: Skip metastases in thyroid cancer leaping the central lymph node compartment.
abstract: OBJECTIVE
  Discontinuous nodal metastasis, or skip metastasis, in thyroid cancer may display clinicopathologic features different from those seen in continuous nodal metastasis and thus may have a different prognosis.
  
  
  METHODS
  Retrospective analysis.
  
  
  METHODS
  Tertiary referral center at a university hospital.
  
  
  METHODS
  Two hundred fifteen consecutive patients who underwent systematic central lymph node dissection for papillary, follicular, or medullary thyroid cancer and who on histopathologic analysis exhibited nodal metastases in at least 1 lateral or mediastinal lymph node compartment.
  
  
  METHODS
  Various clinicopathologic variables that were stratified for tumor entity and type of nodal metastasis (discontinuous vs continuous).
  
  
  RESULTS
  Skip metastases (negative central and positive lateral or mediastinal compartments) were found in 13 (19.7%) of 66 papillary, 0 of 8 follicular, and 30 (21.3%) of 141 medullary thyroid cancers. After adjustment for multiple testing, skip metastasis was only associated with significantly fewer positive lymph nodes: 3.7 vs 12.9 nodes (r = -0.43, P<.001) in papillary thyroid cancer and 6.0 vs 17.1 nodes (r = -0.40, P<.001) in medullary thyroid cancer. No other significant correlation was identified with any other clinicopathologic variable.
  
  
  CONCLUSIONS
  Skip metastasis is an epiphenomenon of low-intensity nodal metastasis in thyroid cancer and entails a moderate risk of local recurrence. Consequently, clearing the central lymph node compartment should be considered when lateral or mediastinal lymph node compartments are involved.
authors.affiliation: Department of General, Visceral, and Vascular Surgery, Martin-Luther-University Halle-Wittenberg, Halle, Germany. gensurg@medizin.uni-halle.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Machens
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Holzhausen
authors.forename: Henning
authors.initials: H
authors.lastname: Dralle
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D018276:Carcinoma, Medullary / Q000473:pathology / Q000601:surgery; D002291:Carcinoma, Papillary / Q000473:pathology / Q000601:surgery; D015331:Cohort Studies; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology / Q000473:pathology*; D009367:Neoplasm Staging; D011336:Probability; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery*; D013965:Thyroidectomy; D016896:Treatment Outcome