Age-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats.
The impact of age on the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats was investigated via 5-bromo-2'-deoxyuridine immunohistochemistry. Animals of different ages were used: 4-week-old, 8-week-old, and 62-week-old. Based upon the present study, the most prominent cell proliferation in the dentate gyrus was observed in the 4-week-old rats, and decreased in direct relation to the age of the animals. In addition, although treadmill exercise increased cell proliferation in the dentate gyrus of animals in all age groups, the most potent enhancing effect appeared in the 8-week-old rats. The present results demonstrate that age is an important factor in the regulation of cell proliferation in the dentate gyrus and that the enhancing effect of the treadmill exercise on cell proliferation also depends on age status.
Kim
Young-Pyo
YP
Department of Physiology, College of Medicine, Kyung Hee University, #1 Hoigi-dong, Dongdaemoon-gu, Seoul 130-701, South Korea.
Kim
Hong
H
Shin
Mal-Soon
MS
Chang
Hyun-Kyung
HK
Jang
Mi-Hyeon
MH
Shin
Min-Chul
MC
Lee
Sam-Jun
SJ
Lee
Hee-Hyuk
HH
Yoon
Jin-Hwan
JH
Jeong
Ill-Gyu
IG
Kim
Chang-Ju
CJ
D000375:Aging / Q000502:physiology*; D000818:Animals; D001973:Bromodeoxyuridine; D002455:Cell Division / Q000502:physiology; D018891:Dentate Gyrus / Q000166:cytology / Q000254:growth & development*; D015536:Down-Regulation / Q000502:physiology; D005080:Exercise Test; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*
D001973:Bromodeoxyuridine