title: Rotenone and rotenoids in cubè resins, formulations, and residues on olives.
abstract: Rotenone and rotenoids (deguelin, beta-rotenolone (12a beta-hydroxyrotenone), tephrosin (12a beta-hydroxydeguelin), 12a alpha-hydroxyrotenone, and dehydrorotenone) were determined in cubè resins and formulations. Cubè resins from Lonchocarpus contain large quantities of deguelin (ca. 21.2%) and smaller quantities of tephrosin (ca. 3.5%) and beta-rotenolone (ca. 3.0%). The composition of commercial formulations may present very different rotenoid contents depending on the extracts used to prepare them. Because these rotenoids also present insecticide activity, the efficacy of these formulations may be very different. The storage stability and photodegradation of some rotenone formulations were studied. Rotenone and rotenoids are very sensitive to solar radiation, which degrades them rapidly, with half-lives in the order of a few tens of minutes. Some formulations show greater disappearance rates than that of cubè resin, indicating that not much attention has been paid to protecting the active ingredients from photodegradation in the formulation. A study on the residues on olives was also carried out to assess not only the rotenone content, but also that of the main rotenoids. At harvest, the residues of deguelin, tephrosin, and beta-rotenolone were 0.10, 0.06, and 0.10 mg/kg, respectively, very similar to rotenone (0.08 mg/kg), and though a few data indicate similar acute toxicity values for deguelin, only rotenone is taken into consideration in the legal determination of the residue.
authors.affiliation: Dipartimento di Tossicologia, Università di Cagliari, via Ospedale 72, 09124 Cagliari, Italy.
authors.forename: Maddalena
authors.initials: M
authors.lastname: Cabizza
authors.forename: Alberto
authors.initials: A
authors.lastname: Angioni
authors.forename: Marinella
authors.initials: M
authors.lastname: Melis
authors.forename: Marco
authors.initials: M
authors.lastname: Cabras
authors.forename: Carlo V
authors.initials: CV
authors.lastname: Tuberoso
authors.forename: Paolo
authors.initials: P
authors.lastname: Cabras
mesh_terms: D029866:Derris / Q000737:chemistry; D007306:Insecticides / Q000032:analysis* / Q000737:chemistry; D031658:Olea / Q000737:chemistry*; D010777:Photochemistry; D012116:Resins, Plant / Q000737:chemistry*; D012402:Rotenone / Q000031:analogs & derivatives* / Q000032:analysis* / Q000737:chemistry; D013472:Sunlight
chemical_list: D007306:Insecticides; D012116:Resins, Plant; D012402:Rotenone; C107676:deguelin