Film coating as a method to enhance the preparation of tablets from dimenhydrinate crystals.
Crystals of dimenhydrinate as a model drug were used for crystal coating, a method that can be applied to increase the flowability of a material and facilitate the tablet making. An increase in particle size was observed during the film coating. The change in shape of the coated particles was also examined. Some physicochemical parameters changed during coating, e.g. the surface free energy parameters and the wetting of the samples. The amount of coating material (and therefore the coating time) influenced several parameters (the shape of the particles, the flow properties and surface free energy parameters, compressibility and compactibility). Several parameters of prepared tablet (porosity, breaking hardness) were examined. Accordingly, coating of the crystals can be performed in order to enhance the handling of a material with insufficient properties for tablet making.
Bajdik
János
J
Department of Pharmaceutical Technology, University of Szeged, H-6720 Szeged, Eötvös u. 6, Hungary.
Pintye-Hódi
Klára
K
Planinsek
Odon
O
Regdon
Géza
G
Dreu
Rok
R
Srcic
Stane
S
Eros
István
I
D000932:Antiemetics; D002626:Chemistry, Pharmaceutical; D003460:Crystallization / Q000379:methods; D004111:Dimenhydrinate; D010316:Particle Size; D013607:Tablets
D000932:Antiemetics; D013607:Tablets; D004111:Dimenhydrinate