Protection of organic trauma in sinoaortic-denervated rats treated with fosinopril.
OBJECTIVE
To study the importance of blood pressure variability in organ protection for long-term treatment with fosinopril in-sinoaortic-denervated (SAD) rats.


METHODS
Fosinopril (15 mg.kg-1.d-1) was given in rat chow for 16 weeks after SAD surgery. Blood pressure variability (BPV) was recorded during 24 h in conscious state. Histopathological changes were evaluated with light microscope and computer-assisted image analysis.


RESULTS
Long-term treatment with fosinopril significantly decreased BPV in SAD rats. The thickness of the left ventricular wall, collagen fraction of the left ventricle and glomerulosclerosis score were all positively related to BPV in untreated and fosinopril-treated SAD rats. Fosinopril markedly prevented the damages of target organs in SAD rats.


CONCLUSIONS
Long-term treatment with fosinopril showed obvious organ protection in SAD rats. The decrease in BPV may significantly contribute to organ protection.
Tao
Xia
X
Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China. taoxia100@yahoo.com.cn
Liu
Gao-lin
GL
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D003714:Denervation / Q000379:methods; D017328:Fosinopril / Q000008:administration & dosage / Q000494:pharmacology*; D006352:Heart Ventricles / Q000473:pathology; D007668:Kidney / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D012849:Sinoatrial Node / Q000294:innervation*; D013997:Time Factors
D000959:Antihypertensive Agents; D020011:Protective Agents; D017328:Fosinopril