title: Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity.
abstract: Anthranilamide analogues such as 23 are potent and highly selective muscarinic M2 antagonists that also show good oral bioavailability and in vivo activity.
authors.affiliation: Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. john.clader@spcorp.com
authors.forename: John W
authors.initials: JW
authors.lastname: Clader
authors.forename: William
authors.initials: W
authors.lastname: Billard
authors.forename: Herbert
authors.initials: H
authors.lastname: Binch
authors.forename: Lian-Yong
authors.initials: LY
authors.lastname: Chen
authors.forename: Gordon
authors.initials: G
authors.lastname: Crosby
authors.forename: Ruth A
authors.initials: RA
authors.lastname: Duffy
authors.forename: Jennifer
authors.initials: J
authors.lastname: Ford
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Kozlowski
authors.forename: Jean E
authors.initials: JE
authors.lastname: Lachowicz
authors.forename: Shengjian
authors.initials: S
authors.lastname: Li
authors.forename: Charles
authors.initials: C
authors.lastname: Liu
authors.forename: Stuart W
authors.initials: SW
authors.lastname: McCombie
authors.forename: Susan
authors.initials: S
authors.lastname: Vice
authors.forename: Gowei
authors.initials: G
authors.lastname: Zhou
authors.forename: William J
authors.initials: WJ
authors.lastname: Greenlee
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001671:Biochemistry / Q000379:methods; D001682:Biological Availability; D016466:CHO Cells; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D018727:Muscarinic Antagonists / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D010880:Piperidines / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D043585:Receptor, Muscarinic M2 / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D062367:ortho-Aminobenzoates / Q000737:chemistry*
chemical_list: C492850:1'-(2-amino-3-methylbenzoyl)-4-(4-((3-chlorophenyl)sulfonyl)phenyl)methyl-1,4'-bipiperidine; D018727:Muscarinic Antagonists; D010880:Piperidines; D043585:Receptor, Muscarinic M2; D062367:ortho-Aminobenzoates; C032727:piperidine; C000219:anthranilamide