title: Anti-alpha-enolase antibodies in pituitary disease.
abstract: A previous study reported a high prevalence of autoantibodies to alpha-enolase in lymphocytic hypophysitis and these antibodies efficiently distinguished lymphocytic hypophysitis from pituitary tumors. To confirm this, we examined autoantibodies to alpha-enolase in patients with lymphocytic hypophysitis (n = 17), pituitary non-functioning adenoma (n = 13), other pituitary diseases (n = 17) and other autoimmune diseases (n = 30), and compared to healthy controls (n = 46). Autoantibodies were found in 41.2%, 46.2%, 23.5%, 20.0% and 4.3%, respectively. Our findings indicate that detection of anti-alpha-enolase antibodies is not suitable for specific diagnosis of lymphocytic hypophysitis.
authors.affiliation: Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita-shi, Osaka, Japan.
authors.forename: Susumu
authors.initials: S
authors.lastname: Tanaka
authors.forename: Ke-Ita
authors.initials: KI
authors.lastname: Tatsumi
authors.forename: Toru
authors.initials: T
authors.lastname: Takano
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Murakami
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Takao
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Yamakita
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Tahara
authors.forename: Akira
authors.initials: A
authors.lastname: Teramoto
authors.forename: Kozo
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Kato
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Amino
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000276:immunology; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology*; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins / Q000276:immunology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000276:immunology*; D010900:Pituitary Diseases / Q000175:diagnosis / Q000201:enzymology* / Q000276:immunology*; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000276:immunology; D025521:Tumor Suppressor Proteins / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D025521:Tumor Suppressor Proteins; C095157:ENO1 protein, human; D010751:Phosphopyruvate Hydratase