Hydrolysis of N,N- and N,S-dimethyl derivatives of 2-thiophenobarbital.
Kinetics of hydrolysis of N,N- and N,S-dimethyl-2-thiophenobarbital and products of this reaction were investigated. The UV spectroscopy served as a tool for kinetic investigations and chromatography was used to separate and isolate the main products of hydrolysis. These products were identified by spectroscopic methods and the course of hydrolysis of both isomers was compared.
Tarsa
Monika
M
Department of Organic Chemistry, Medical College, Jagiellonian University, 9 Medyczna Str., 30-688 Kraków, Poland.
Zuchowski
Grzegorz
G
Bojarski
Jacek
J
D000465:Algorithms; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006868:Hydrolysis; D007536:Isomerism; D007700:Kinetics; D013058:Mass Spectrometry; D010634:Phenobarbital / Q000031:analogs & derivatives / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
C481456:N,N-dimethyl-2-thiophenobarbital; C481457:N,S-dimethyl-2-thiophenobarbital; D010634:Phenobarbital