Indecent exposure: when telomeres become uncapped.
The protective "cap" that assembles at chromosome ends recruits and controls an intricate network of biochemical activities, each one critical for telomere structure and the maintenance of genomic stability. Recent studies have uncovered the components of telomere caps and have started to define the pathways that lead from telomere dysfunction to chromosomal catastrophe.
Ferreira
Miguel Godinho
MG
Telomere Biology Laboratory, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3PX, United Kingdom.
Miller
Kyle M
KM
Cooper
Julia Promisel
JP
D000818:Animals; D002869:Chromosome Aberrations; D004249:DNA Damage; D006801:Humans; D008958:Models, Molecular; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism; D019098:Telomerase / Q000378:metabolism; D016615:Telomere / Q000378:metabolism / Q000502:physiology*
D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; D019098:Telomerase