title: [Clinical practice guidelines: Standards, Options and Recommendations for the diagnosis of carcinomas of unknown primary site].
abstract: BACKGROUND
  The "Standards, Options and Recommendations" (SOR) project, which started in 1993, is a collaboration between the Federation of French Cancer Centers (FNCLCC), the 20 French Regional Cancer Centers, and specialists from French public universities, general hospitals and private clinics. The main objective is the development of clinical practice guidelines to improve the quality of health care and the outcome of cancer patients.
  
  
  OBJECTIVE
  To define Clinical Practice Guidelines (CPG) for the diagnosis of carcinomas of unknown primary site.
  
  
  METHODS
  The methodology is based on a literature review and critical appraisal by a multidisciplinary group of experts who define the CPGs according to the definitions of the Standards, Options and Recommendations project. Once the guidelines has been defined, the document is submitted for review by independent reviewers.
  
  
  RESULTS
  The main recommendations for the diagnosis of carcinomas of unknown primary site are: 1) Diagnostic strategy should aim to identify anatomoclinical entities of carcinomas of unknown primary site for which there is a specific treatment. For other anatomoclinical entities, identification of the primary tumour has no impact on the prognostic or therapeutic consequences, thus a systematic complete assessment is unnecessary. 2) An immunohistochemical investigation for the diagnosis should be performed using an appropriate panel of specific antibodies. This should enable the diagnosis of lymphoma, melanoma, germ cell tumour and sarcoma to be eliminated and the diagnosis of prostate, breast, ovary, thyroid or neuroendocrine tumours to be positively identified. 3) A sample can be frozen to enable typing, cytogenetic and, particularly, molecular biological studies to be performed later. 4) The clinician and pathologist should compare their opinions before and after the pathological diagnosis.
authors.affiliation: Oncologue médical, Centre Eugène Marquis, Rennes.
authors.forename: Thierry
authors.initials: T
authors.lastname: Lesimple
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Voigt
authors.forename: Anne
authors.initials: A
authors.lastname: Bataillard
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Coindre
authors.forename: Stéphane
authors.initials: S
authors.lastname: Culine
authors.forename: Alain
authors.initials: A
authors.lastname: Lortholary
authors.forename: Yacine
authors.initials: Y
authors.lastname: Merrouche
authors.forename: Gérard
authors.initials: G
authors.lastname: Ganem
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Kaminsky
authors.forename: Sylvie
authors.initials: S
authors.lastname: Negrier
authors.forename: Maurice
authors.initials: M
authors.lastname: Perol
authors.forename: Pierre
authors.initials: P
authors.lastname: Bedossa
authors.forename: Gérard
authors.initials: G
authors.lastname: Bertrand
authors.forename: Roland
authors.initials: R
authors.lastname: Bugat
authors.forename: Karim
authors.initials: K
authors.lastname: Fizazi
mesh_terms: D006801:Humans; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis*