title: Serum lipid and lipoprotein changes induced by preparations containing low-dose ethinylestradiol plus levonorgestrel.
abstract: The purpose of the present study was to evaluate the effects on lipid metabolism of a new low-dose monophasic combination oral contraceptive with 100 microg levonorgestrel and 20 microg ethinylestradiol. Sixty healthy women aged 18-45 years were administered the medication during three cycles. The study participants were screened for lipid changes. The differences in cholesterol and triglyceride levels were not statistically significant, but high-density lipoprotein levels were significantly lower and low-density lipoprotein levels were significantly higher than the baseline. Women at risk of cardiovascular disease should be carefully monitored even when using low-dose preparations.
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Medicine, Kahramanmaras Sutcuimam University, Kahramanmaras, Turkey. gurkankiran@mail.ksu.edu.tr
authors.forename: Gurkan
authors.initials: G
authors.lastname: Kiran
authors.forename: Hakan
authors.initials: H
authors.lastname: Kiran
authors.forename: Hasan C
authors.initials: HC
authors.lastname: Ekerbicer
mesh_terms: D000328:Adult; D003276:Contraceptives, Oral; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage*; D008074:Lipoproteins / Q000097:blood*; D014280:Triglycerides / Q000097:blood*
chemical_list: D003276:Contraceptives, Oral; D004338:Drug Combinations; D008074:Lipoproteins; D014280:Triglycerides; D004997:Ethinyl Estradiol; D016912:Levonorgestrel