title: Newly discovered tachykinins raise new questions about their peripheral roles and the tachykinin nomenclature.
abstract: The tachykinin family has recently been extended by the discovery of a third tachykinin gene encoding previously unknown mammalian tachykinins (hemokinin 1, endokinin A and endokinin B) that have a widespread peripheral distribution and a tachykinin NK(1) receptor selectivity. This and the identification of other tachykinin-like peptides such as C14TKL-1 and virokinin raise many questions about the roles played by tachykinins in peripheral tissues and render terms such as 'neurokinins' and 'SP receptor' inappropriate.
authors.affiliation: Pharmacology Department, Menarini Ricerche, Via Rismondo 12/A, 50131, Florence, Italy. chimfarm@menarini-ricerche.it
authors.forename: Riccardo
authors.initials: R
authors.lastname: Patacchini
authors.forename: Alessandro
authors.initials: A
authors.lastname: Lecci
authors.forename: Peter
authors.initials: P
authors.lastname: Holzer
authors.forename: Carlo Alberto
authors.initials: CA
authors.lastname: Maggi
mesh_terms: D000818:Animals; D006801:Humans; D013045:Species Specificity; D015320:Tachykinins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D009626:Terminology as Topic
chemical_list: D015320:Tachykinins