Mitotic spindle pole separation.
Eukaryotic cells utilize a microtubular spindle to segregate chromosomes during mitosis. Chromosome segregation requires the timely separation of the mitotic spindle poles to which the chromosomes are attached. Recent studies at the molecular and cellular levels have provided new insights into the mechanism and regulation of this process. On the one hand, the process now seems more complex, as redundant mechanisms apparently overlap in function during cell division. On the other hand, some of these processes may be acting continuously during the various stages of spindle pole separation, suggesting an underlying simplicity.
Saunders
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Department of Biology, Mudd Hall, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218-2685, USA.