Electron beam irradiation: a novel technology for the development of transdermal system of isosorbide dinitrate.
The development of a transdermal delivery system for isosorbide dinitrate (ISDN) using electron beam irradiation was studied. The solid state stability of the drug to irradiation was assessed. The drug was dissolved in 2-ethylhexylacrylate (EHA)-acrylic acid (AA) system and this solution was directly irradiated on a backing membrane (Scotchpak1006) at different doses to get transdermal patches. The developed systems were evaluated for residual monomer content, equilibrium weight swelling ratios (EWSR), differential scanning calorimetry (DSC), weight uniformity, thickness uniformity, drug content and content uniformity, peel strength, in vitro release, skin permeation kinetics and skin irritation potential. The developed system possessed excellent adhesive properties. Increase in the irradiation doses did not have a significant effect on the peel strength values. The systems exhibited promising skin permeation kinetics and no skin irritating potential, both of which are important properties for transdermal drug delivery. The ISDN-EHA-AA system developed at an irradiation dose of 50 kGy showed a higher skin permeation profile as compared to an internationally marketed transdermal matrix system of ISDN.
Kotiyan
P N
PN
Pharmaceutical Division, Department of Chemical Technology (Autonomous), University of Mumbai, Nathalal Parikh Marg, Matunga, Mumbai 400 019, India. kotiyan_pramila_n@lilly.com
Vavia
P R
PR
Bhardwaj
Y K
YK
Sabarwal
S
S
Majali
A B
AB
D000279:Administration, Cutaneous; D000818:Animals; D002152:Calorimetry, Differential Scanning; D002851:Chromatography, High Pressure Liquid; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D005260:Female; D066298:In Vitro Techniques; D007548:Isosorbide Dinitrate / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000528:radiation effects*; D010539:Permeability; D011817:Rabbits; D012867:Skin / Q000378:metabolism; D012995:Solubility; D013696:Temperature; D013997:Time Factors
D007548:Isosorbide Dinitrate