title: Secondary prevention of vitamin D-deficiency rickets.
abstract: Reports of vitamin D-deficiency rickets and its associated morbidity continue among inadequately supplemented, dark-skinned breastfed infants. Despite the new vitamin D dietary guidelines, there remain significant numbers of unsupplemented breastfed infants. Here we report a case of subclinical vitamin D-deficiency rickets. This patient had biochemical and radiographic but not clinical evidence for rickets. We propose a new step of screening high-risk infants for subclinical rickets using wrist films paired with 25-hydroxyvitamin D levels.
authors.affiliation: Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA. jespence@jhmi.edu
authors.forename: Jean T
authors.initials: JT
authors.lastname: Spence
authors.forename: Janet R
authors.initials: JR
authors.lastname: Serwint
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D018798:Anemia, Iron-Deficiency / Q000150:complications / Q000188:drug therapy; D001942:Breast Feeding; D002118:Calcium / Q000627:therapeutic use*; D019587:Dietary Supplements; D004872:Ergocalciferols / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007501:Iron / Q000627:therapeutic use; D008297:Male; D012279:Rickets / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
chemical_list: D004872:Ergocalciferols; D007501:Iron; D000469:Alkaline Phosphatase; D002118:Calcium