Hyperinsulinaemic hypoglycaemia in preterm neonates.
Hyperinsulinism in infancy (HI) is an important cause of severe and recurrent hypoglycaemia in newborn infants. It usually appears in infants born at term, and only one case of its occurrence in a prematurely born infant has been reported as an incidental finding. This is a report of seven infants born at 31-36 weeks gestation who experienced severe persistent hyperinsulinism. Two infants were large for dates. All infants were difficult to manage, suggesting that the occurrence of HI with prematurity may be associated with a particularly aggressive illness. HI should be considered in the differential diagnosis of severe hypoglycaemia in preterm infants.
Hussain
K
K
London Centre for Paediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children NHS Trust, London WC1N 3JH, UK. K.Hussain@ich.ucl.ac.uk
Aynsley-Green
A
A
D001724:Birth Weight; D002740:Chlorothiazide / Q000627:therapeutic use; D003981:Diazoxide / Q000627:therapeutic use; D004232:Diuretics; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000150:complications*; D007003:Hypoglycemia / Q000097:blood / Q000209:etiology* / Q000628:therapy; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000097:blood / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D008297:Male; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use
D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D002740:Chlorothiazide; D005947:Glucose; D003981:Diazoxide