title: Demystifying the three dimensional structure of G protein-coupled receptors (GPCRs) with the aid of molecular modeling.
abstract: We review our recent work on adenosine receptors, a family of GPCRs; focusing our attention on A3 adenosine receptor, we have demonstrated that the reciprocal integration of different theoretical and experimental disciplines can be very useful for the successful protein-based design of new, potent and selective receptor ligands.
authors.affiliation: Molecular Modeling Section, Department of Pharmaceutical Sciences, University of Padova, Padova, Italy. stefano.moro@unipd.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Moro
authors.forename: Francesca
authors.initials: F
authors.lastname: Deflorian
authors.forename: Giampiero
authors.initials: G
authors.lastname: Spalluto
authors.forename: Giorgia
authors.initials: G
authors.lastname: Pastorin
authors.forename: Barbara
authors.initials: B
authors.lastname: Cacciari
authors.forename: Soo-Kyung
authors.initials: SK
authors.lastname: Kim
authors.forename: Kenneth A
authors.initials: KA
authors.lastname: Jacobson
mesh_terms: D000595:Amino Acid Sequence; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D058915:Purinergic P1 Receptor Antagonists; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology; D018047:Receptors, Purinergic P1 / Q000737:chemistry*; D015398:Signal Transduction; D040681:Structural Homology, Protein
chemical_list: D058915:Purinergic P1 Receptor Antagonists; D011725:Pyridines; D018047:Receptors, Purinergic P1