[Clinical significance of histological types of prostatic cancer].
Biopsy material obtained from 310 patients with prostatic cancer (PC) was used in the study of the incidence rate of different PC histological types, of tumor cell immunophenotype and differentiation by Glison. The results of the study have shown that definition of the tumor histological type and tumor immunophenotype facilitates identification of tumors with the most malignant potential. Therefore, this definition should be included into the diagnostic complex in the study of PC. Choice of treatment policy should not be based only on differentiation of the tumor process by Glison. The decision should be made only after establishment of histogenesis and immunophenotype of tumor cells. The presence of neuroendocrine differentiation is an unfavourable prognostic factor.
Medvedev
V L
VL
Matsionis
A E
AE
Medvedeva
L A
LA
D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D001706:Biopsy; D002471:Cell Transformation, Neoplastic; D053379:Chromogranin A; D002864:Chromogranins; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D018358:Neuroendocrine Tumors / Q000175:diagnosis / Q000473:pathology; D011379:Prognosis; D017430:Prostate-Specific Antigen; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology / Q000473:pathology*; D012426:Russia / Q000453:epidemiology
D000911:Antibodies, Monoclonal; D014408:Biomarkers, Tumor; D053379:Chromogranin A; D002864:Chromogranins; D017430:Prostate-Specific Antigen