title: Two new cytotoxic clerodane diterpenoids from Casearia membranacea.
abstract: In addition to casearlucin A (3), two new clerodane diterpenes, caseamembrols A (1) and B (2) have been isolated from the leaves and twigs of Casearia membranacea by bioassay-guided fractionation. The structures of the new compounds were established on the basis of extensive 1D- and 2D-NMR spectroscopic analysis. Compounds 1-3 exhibited significant cytotoxicity against human prostate (PC-3) cancer cells.
authors.affiliation: Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan, Republic of China. ycshen@mail.nsysu.edu.tw
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
authors.forename: Li-Tung
authors.initials: LT
authors.lastname: Wang
authors.forename: Chih-Hsin
authors.initials: CH
authors.lastname: Wang
authors.forename: Ashraf Taha
authors.initials: AT
authors.lastname: Khalil
authors.forename: Jih-Hwa
authors.initials: JH
authors.lastname: Guh
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D037821:Casearia / Q000737:chemistry*; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D045785:Diterpenes, Clerodane; D000431:Ethanol; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology; D012997:Solvents; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045785:Diterpenes, Clerodane; D012997:Solvents; C488475:caseamembrol A; C488476:caseamembrol B; D000431:Ethanol