Effect of several factors on the mechanical properties of pressure-sensitive adhesives used in transdermal therapeutic systems.
The effects of coating thickness, type of adhesive, and type and concentration of enhancer on the mechanical properties of two acrylic pressure-sensitive adhesives (PSAs) were investigated using a 2(4) factorial design and an optimization technique. Sixteen formulations containing 0% or 10% of either caprylic acid or methyl laurate in two different PSAs, namely Duro-Tak 87-2196 and Duro-Tak 87-2097, were prepared. The adhesive properties of these laminates were evaluated by applying the 90 degrees Dynamic Adhesive Strength Peel Test (90 degrees DASPT) and 1800 Release Liner Peel Test (180 degrees RLPT). Coating thickness, concentration of enhancer, and type of adhesive did affect the 90 degrees DASPT. For the 180 degrees RLPT, the most significant factors were coating thickness and concentration of enhancer, with a strong interaction observed between the two. Coating thickness and concentration of enhancer were also used to create mathematical models that correlated these factors with the mechanical properties of the PSAs. For this purpose, the optimization technique 3(2) was applied. It was found that the correlation of the above factors can be adequately described with polynomial equations, which can be used for predicting the mechanical properties of the laminates containing the above PSAs and methyl laurate (0%-10%).
Dimas
D A
DA
School of Pharmacy, Department of Pharmaceutical Technology, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.
Dallas
P P
PP
Rekkas
D D
DD
Choulis
N H
NH
D000179:Acrylates / Q000737:chemistry; D000268:Adhesiveness; D000279:Administration, Cutaneous; D002210:Caprylates / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations / Q000737:chemistry; D016503:Drug Delivery Systems; D007848:Laurates / Q000737:chemistry; D008956:Models, Chemical; D011312:Pressure; D012869:Skin Absorption / Q000502:physiology; D014014:Tissue Adhesives / Q000737:chemistry*
D000179:Acrylates; D002210:Caprylates; D003692:Delayed-Action Preparations; D007848:Laurates; D014014:Tissue Adhesives; C089549:lauric acid methyl ester; C031492:octanoic acid