Dissemination of emm28 erythromycin-, clindamycin- and bacitracin-resistant Streptococcus pyogenes in Spain.
Reported here is an unusual cluster of non-invasive infections caused by an emm28 Streptococcus pyogenes strain resistant to bacitracin, erythromycin and clindamycin detected in Santander, Spain. Since one of the characteristics of group A streptococci is their almost uniform susceptibility to bacitracin, this finding was unusual, and a search for bacitracin-resistant Streptococcus pyogenes strains was conducted in two other distant cities of Spain (Madrid and San Sebastián) where their presence was confirmed. These strains were frequently associated with erythromycin- and clindamycin-resistance, and most of them belonged to a unique emm28 T28, ST52 clone.
Perez-Trallero
E
E
Microbiology Department, Hospital Donostia, Paseo Dr. Beguiristain s/n, 20014 San Sebastián, Spain. mikrobiol@terra.es
Garcia
C
C
Orden
B
B
Marimon
J M
JM
Montes
M
M
D001414:Bacitracin / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D016000:Cluster Analysis; D015331:Cohort Studies; D024881:Drug Resistance, Bacterial; D018432:Drug Resistance, Multiple; D004917:Erythromycin / Q000494:pharmacology*; D005260:Female; D005798:Genes, Bacterial; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D015337:Multicenter Studies as Topic; D010597:Pharmacogenetics; D012680:Sensitivity and Specificity; D013030:Spain / Q000453:epidemiology; D013290:Streptococcal Infections / Q000188:drug therapy / Q000453:epidemiology* / Q000235:genetics; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000235:genetics
D001414:Bacitracin; D002981:Clindamycin; D004917:Erythromycin