Synthesis of hexahydropyridazine-3-phosphonic acid.
The synthesis of hexahydropyridazine-3-phosphonic acid (piperidazine-3-phosphonic acid) was performed via a hetero-Diels-Alder reaction followed by Lewis acid-catalyzed phosphonylation. This two-step procedure was improved to a one-pot reaction.
Kaname
Mamoru
M
Faculty of Pharmaceutical Sciences, Hokuriku University, Kanagawa-machi Ho-3, Kanazawa 920-1181, Japan.
Yoshinaga
Kazuo
K
Arakawa
Yasushi
Y
Yoshifuji
Shigeyuki
S
D002384:Catalysis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry*; D011724:Pyridazines / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D007202:Indicators and Reagents; D063065:Organophosphonates; D011724:Pyridazines; C488486:hexahydropyridazine-3-phosphonic acid