Statistical optimization of gastric floating system for oral controlled delivery of calcium.
The development of an optimized gastric floating drug delivery system is described. Statistical experimental design and data analysis using response surface methodology is also illustrated. A central, composite Box-Wilson design for the controlled release of calcium was used with 3 formulation variables: X1 (hydroxypropyl methylcellulose [HPMC] loading), X2 (citric acid loading), and X3 (magnesium stearate loading). Twenty formulations were prepared, and dissolution studies and floating kinetics were performed on these formulations. The dissolution data obtained were then fitted to the Power Law, and floating profiles were analyzed. Diffusion exponents obtained by Power Law were used as targeted response variables, and the constraints were placed on other response variables. All 3 formulation variables were found to be significant for the release properties (P <.05), while only HPMC loading was found to be significant for floating properties. Optimization of the formulations was achieved by applying the constrained optimization. The optimized formulation delivered calcium at the release rate of 40 mg/hr, with predicted n and T50% values at 0.93 and 3.29 hours, respectively. Experimentally, calcium was observed to release from the optimized formulation with n and T50% values of 0.89 (+/- 0.10) and 3.20 (+/- 0.21) hours, which showed an excellent agreement. The quadratic mathematical model developed could be used to further predict formulations with desirable release and floating properties.
Li
S
S
Controlled Drug-Delivery Research Center, Rutgers College of Pharmacy, 41 Gordon Road, Suite D, Piscataway, NJ 08854, USA. shoufeng.li@pharma.novartis.com
Lin
S
S
Chien
Y W
YW
Daggy
B P
BP
Mirchandani
H L
HL
D000284:Administration, Oral; D000704:Analysis of Variance; D001682:Biological Availability; D002118:Calcium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002119:Calcium Carbonate / Q000008:administration & dosage / Q000378:metabolism; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004339:Drug Compounding / Q000379:methods / Q000706:statistics & numerical data; D016503:Drug Delivery Systems / Q000706:statistics & numerical data*; D010592:Pharmaceutic Aids / Q000008:administration & dosage / Q000493:pharmacokinetics; D012044:Regression Analysis; D015203:Reproducibility of Results
D003692:Delayed-Action Preparations; D010592:Pharmaceutic Aids; D002119:Calcium Carbonate; D002118:Calcium