title: Design and synthesis of a series of chlorinated 3-deazaadenine analogues.
abstract: A series of chlorinated adenine analogues were designed with sights set on the development of potential antitumor agents. During the synthetic efforts, two unexpected compounds were identified. Their synthesis, along with synthesis of the chlorinated targets is presented herein.
authors.affiliation: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA. kseley@umbc.edu
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Seley
authors.forename: Peter I
authors.initials: PI
authors.lastname: O'Daniel
authors.forename: Samer
authors.initials: S
authors.lastname: Salim
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D002713:Chlorine / Q000737:chemistry; D015195:Drug Design; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D011687:Purines; D002713:Chlorine; C055133:3-deazaadenine; D000225:Adenine