title: Amino acid composition of soybean protein increased postprandial carbohydrate oxidation in diabetic mice.
abstract: The effects of an amino acid mixture simulating dietary soybean protein on the postprandial energy metabolism was investigated using type II diabetic mice. KK-A(y) strain mice were fed restrictive isoenergetic and isonitrogenous diets (35% of energy as protein and 5% as fat) based on either casein, soybean protein isolate hydrolysate (SPI-H), SPI-HET (ethanol unsoluble fraction of SPI-H), SPI-AA and casein-AA (amino acid mixtures simulating SPI-H and casein). To measure dietary carbohydrate oxidation, the animals were fed a diet containing (13)C-glucose. Postprandial respiratory quotient and expired (13)CO(2) were higher in the SPI-AA than in the casein-AA group, as the differences were similarly observed in mice fed SPI-H and casein diet. No significant differences were observed in the postprandial respiratory quotient and expired (13)CO(2) between the SPI-H and SPI-HET group. In conclusion, this study on food-restricted mice indicates that the amino acid mixtures simulating SPI-H or casein could affect postprandial energy metabolism in diabetic mice, as observed in those fed SPI-H or casein in the form of peptide or protein.
authors.affiliation: Department of Food and Nutrition, School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan. kenjo@food.sugiyama-u.ac.jp
authors.forename: Kengo
authors.initials: K
authors.lastname: Ishihara
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Fukuchi
authors.forename: Wataru
authors.initials: W
authors.lastname: Mizunoya
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Mita
authors.forename: Yoko
authors.initials: Y
authors.lastname: Fukuya
authors.forename: Tohru
authors.initials: T
authors.lastname: Fushiki
authors.forename: Kyoden
authors.initials: K
authors.lastname: Yasumoto
mesh_terms: D000596:Amino Acids / Q000493:pharmacokinetics*; D000818:Animals; D001835:Body Weight / Q000502:physiology; D002364:Caseins / Q000493:pharmacokinetics; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000493:pharmacokinetics*; D004734:Energy Metabolism / Q000502:physiology*; D005947:Glucose / Q000493:pharmacokinetics; D008055:Lipids / Q000493:pharmacokinetics; D008297:Male; D051379:Mice; D010084:Oxidation-Reduction; D019518:Postprandial Period / Q000502:physiology; D011492:Protein Hydrolysates / Q000493:pharmacokinetics; D030262:Soybean Proteins / Q000493:pharmacokinetics*
chemical_list: D000596:Amino Acids; D002364:Caseins; D004040:Dietary Carbohydrates; D008055:Lipids; D011492:Protein Hydrolysates; D030262:Soybean Proteins; D005947:Glucose