title: Cytotoxic C-benzylated dihydrochalcones from Uvaria acuminata.
abstract: Two new C-benzylated dihydrochalcones, isochamuvaritin (1) and acumitin (2), have been isolated from the African medicinal plant Uvaria acuminata, together with the previously reported benzylbenzoate (3), uvaretin (4), isouvaretin (5), diuvaretin (6), and uvangoletin (7). The structural elucidation of compounds 1 and 2 in spectroscopic studies is described. C-Benzylated dihydrochalcones, especially 1, 2, 4, and 6, showed considerable cytotoxicity toward human promyelocytic leukemia HL-60 cells.
authors.affiliation: Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan. ichimaru@kobepharma-u.ac.jp
authors.forename: Momoyo
authors.initials: M
authors.lastname: Ichimaru
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Nakatani
authors.forename: Tomoko
authors.initials: T
authors.lastname: Takahashi
authors.forename: Yumi
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: Masataka
authors.initials: M
authors.lastname: Moriyasu
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kato
authors.forename: Simon G
authors.initials: SG
authors.lastname: Mathenge
authors.forename: Francis D
authors.initials: FD
authors.lastname: Juma
authors.forename: Joseph N
authors.initials: JN
authors.lastname: Nganga
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002599:Chalcone / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts; D018517:Plant Roots / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D031046:Uvaria / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D002599:Chalcone