Cellular differentiation: the violin strikes up another tune.
A switch in cellular identity in budding yeast requires the ubiquitin-dependent elimination of pre-existing master regulators encoded by the MAT locus. Failure to disassemble the prior state not only impairs the cell type transition but imparts a hybrid cellular fate. This theme will undoubtedly arise in many developmental and disease contexts.
Cook
Michael A
MA
Department of Medical Genetics and Microbiology, University of Toronto, M5S 1A8, Toronto, Canada.
Tyers
Mike
M
D002454:Cell Differentiation; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal / Q000235:genetics*; D018398:Homeodomain Proteins / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism; D004718:Saccharomycetales / Q000235:genetics*; D015398:Signal Transduction; D014157:Transcription Factors; D025801:Ubiquitin / Q000378:metabolism
D018398:Homeodomain Proteins; C096063:MATA1 protein, S cerevisiae; C062928:MATA2 protein, S cerevisiae; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D025801:Ubiquitin