Late cytomegalovirus polyradiculopathy following haploidentical CD34+-selected hematopoietic stem cell transplantation.
A 55-year-old man with acute myeloid leukemia in second relapse presented 4 months after haploidentical CD34+-selected hematopoietic stem cell transplantation (HSCT) with symmetric, progressive neurological deficits of the lower extremities. Although there was no molecular evidence for drug resistance in the cerebral-spinal fluid, antiviral combination therapy failed to control the rapidly progressing CMV polyradiculopathy (PRP) and encephalitis, which were confirmed by autopsy studies. Late CMV PRP as an unusual manifestation of CMV disease should be kept in mind in patients with suggestive neurological symptoms after HSCT.
Zeiser
R
R
Department of Hematology/Oncology, Medical Center, University of Freiburg, Hugstetterstrasse 55, Freiburg 79106, Germany. zeiser@mm11.ukl.uni-freiburg.de
Grüllich
C
C
Bertz
H
H
Pantazis
G
G
Hufert
F T
FT
Bley
T A
TA
Finke
J
J
D000208:Acute Disease; D018952:Antigens, CD34 / Q000378:metabolism; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000473:pathology; D017809:Fatal Outcome; D006238:Haploidy; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006801:Humans; D007951:Leukemia, Myeloid / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011128:Polyradiculopathy / Q000473:pathology / Q000821:virology*
D018952:Antigens, CD34