title: An efficient direct alpha-alkylation of ketones with primary alcohols catalyzed by [Ir(cod)Cl]2/PPh3/KOH system without solvent.
abstract: alpha-Alkylation of ketones was successfully achieved by the reaction of ketones with alcohols catalyzed by iridium complexes in the presence of a small amount of base. For example, 2-octanone was allowed to react with butanol under the influence of [Ir(cod)Cl]2/PPh3/KOH to give 6-dodecanone in good yield. The reaction was found to proceed by using a 1:1 mixture of ketone and alcohol without use of any solvent.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Kansai University, Suita, Osaka 564-8680, Japan.
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Taguchi
authors.forename: Hideto
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Hirabayashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sakaguchi
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Ishii