title: Protein tyrosine phosphatases in disease processes.
abstract: Given the importance of tyrosine phosphorylation of proteins in signalling pathways, it is perhaps not surprising that protein tyrosine phosphatases (PTPs) are involved in the pathogenesis of certain human diseases. A PTP produced by the Yersinia bacteria (which can cause bubonic plague, septicemia and enteric diseases) is thought to be used as a 'weapon' against host cell functions. In addition, dysfunction of cells' endogenous PTPs may contribute to defective immune function, to cancer and to diabetes.
authors.affiliation: Department of Biological Chemistry, The University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: E G
authors.initials: EG
authors.lastname: Ninfa
authors.forename: J E
authors.initials: JE
authors.lastname: Dixon