[A case of parotid carcinoma with hepatic metastasis that responded remarkably to combination chemotherapy of docetaxel, cisplatin and 5-fluorouracil].
A patient who had parotid gland carcinoma with hepatic metastasis (T4N2bM1) underwent 3 cycles of neoadjuvant chemotherapy with docetaxel, cisplatin and fluorouracil (TPF). After this treatment, the patient showed a PR in the primary site and a CR in the hepatic metastasis. Left total parotidectomy and modified radical neck dissection were then performed followed by postoperative irradiation of 40 Gy. No recurrence in the primary site or the neck was seen, but in the metastatic site a recurrence was observed at 8 weeks after the first chemotherapy. The same chemotherapy is now applied in an outpatient setting. Toxicities with neutropenia, nausea and vomiting of CTC Grade 3 were observed, but these toxicities were mild and manageable. TPF is considered to show clinical activity for advanced parotid gland carcinoma, and we consider further investigation necessary.
Furusawa
Jun
J
Dept. of Otolaryngology, Kushiro General Hospital.
Mizumati
Takatsugu
T
Iizuka
Keiji
K
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D010307:Parotid Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D043823:Taxoids / Q000008:administration & dosage
D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil