title: Granulomatous chest disease following intravesical bacillus Calmette-Guerin immunotherapy.
abstract: Bacillus Calmette-Guerin (BCG) is well accepted as an intravesicular method of treatment of bladder cancer. Although well tolerated in the majority of patients, adverse local and systemic adverse effects of this therapy have been described. In particular, lung disease complicating intravesicular use of BCG has been reported, producing 5 recognized forms of chest disease: 1) allergic interstitial lung disease, 2) miliary infection, 3) empyema, 4) diffuse alveolar damage, and 5) localized consolidative or cavitary lung disease. We report an asymptomatic form of pulmonary disease complicating intravesical BCG therapy, that of pulmonary granulomas with mediastinal and hilar lymph node enlargement.
authors.affiliation: University of Vermont College of Medicine, Burlington, VT 05401, USA.
authors.forename: Hannah
authors.initials: H
authors.lastname: Chang
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Klein
authors.forename: Mitchell
authors.initials: M
authors.lastname: Norotsky
authors.forename: Kumarasen
authors.initials: K
authors.lastname: Cooper
mesh_terms: D000368:Aged; D001500:BCG Vaccine / Q000009:adverse effects* / Q000627:therapeutic use; D006099:Granuloma / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000473:pathology; D006801:Humans; D007167:Immunotherapy / Q000009:adverse effects*; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000382:microbiology*; D008297:Male; D014057:Tomography, X-Ray Computed; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000628:therapy*
chemical_list: D001500:BCG Vaccine