Prolongation of life span associated with immunological modification by chronic low-dose-rate irradiation in MRL-lpr/lpr mice.
Chronic low-dose-rate gamma irradiation at 0.35 or 1.2 mGy/h prolonged the life span of MRL-lpr/lpr mice carrying a deletion in the apoptosis-regulating Fas gene that markedly shortens life due to severe autoimmune disease. Immunological modifications as indicated by a significant increase of CD8(+) T cells and a significant decrease of CD3(+) CD45R/B220(+) as well as CD45R/B220(+) CD40(+) cells were found in parallel with amelioration of total-body lymphadenopathy, splenomegaly, proteinuria, and kidney and brain syndromes.
Ina
Yasuhiro
Y
Low Dose Radiation Research Center, Central Research Institute of Electric Power Industry, 2-11-1 Iwado-kita, Komae, Tokyo 201-8511, Japan. y-i@criepi.denken.or.jp
Sakai
Kazuo
K
D000386:AIDS-Related Complex / Q000276:immunology / Q000473:pathology; D000375:Aging / Q000528:radiation effects*; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008136:Longevity / Q000528:radiation effects*; D008180:Lupus Erythematosus, Systemic; D008213:Lymphocyte Activation / Q000528:radiation effects*; D051379:Mice; D019463:Mice, Inbred MRL lpr; D011507:Proteinuria / Q000276:immunology / Q000473:pathology; D011829:Radiation Dosage; D013154:Spleen / Q000276:immunology / Q000473:pathology / Q000528:radiation effects*; D013163:Splenomegaly / Q000276:immunology / Q000473:pathology; D015996:Survival Rate; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology / Q000528:radiation effects*; D014916:Whole-Body Irradiation / Q000379:methods