[Drug interference with the determination of urinary proteins with pyrocatechol violet Upro Vitros slides].
The purpose of this study is to investigate drug's interference on proteinuria's determination with pyorcatechol violet (Vitros technology). Five drugs were selected: gelatin based vascular replacement fluids (Plasmion), deferoxamine (Desféral), ceftriaxone (Rocéphine), ceftazidime (Fortum) and imipeneme (Tienam). To state precisely the role played by slide's technology, a liquid phase dosage was simultaneously made with pyrocatechol violet. No interference was notified with therapeutical range for four of them: gelatin, deferoxamine, ceftazidime and imipeneme. Slides technology prevents from gelatin's interference because the colorant is sensible to this drugs. On the other hand, positive interference was observed with ceftriaxone for urinary concentration upper than 0.75 g/L. This concentration is lower than that notified by Vitros laboratory in the technical data.
Delacour
H
H
Laboratoire de biochimie, toxicologie cliniques, Hôpital d'instruction des armées du Val de Grâce, 74 boulevard Port Royal, 75005 Paris.
Dami
A
A
Gidenne
S
S
Vigezzi
J-F
JF
Le Rest
N
N
Ramirez
J
J
D001557:Benzenesulfonates; D004347:Drug Interactions; D006801:Humans; D011507:Proteinuria / Q000652:urine*
D001557:Benzenesulfonates; C009134:pyrocatechol violet