title: [Association of HLA class I and leukemia in mestizo patients of the state of Zulia, Venezuela].
abstract: The Human Leukocyte Allele (HLA) Class I (A, B, C) and Acute Lymphoid Leukemia and Myeloid Leukemia association, was determined by polymerase chain reaction--sequence specific primers (PCR-SSP) in 60 patients and 30 healthy controls. The results were reported as allelic frequencies and haplotype. The Chi-square corrected, Fisher's Test, Relative risk and etiologic fraction were calculated. A significant positive association was showed between HLA-B*39 (RR = 16.184; p = 0.0237) and HLA C*03 (RR = 5.0; p = 0.0127) alleles and Mycloid Leukaemia. Positive associations between haplotypes 2 loci: HLA-A*02-C*03 (RR = 6.0; p = 0.0153), A*24-C*03 (RR = 16.184; p = 0.0237), B*40-C*03 (RR = 10.706; p = 0.0021) and haplotype 3 loci: HLA-A*02-B*40-C*03 (RR = 8.11; p = 0.0102) and Myeloid Leukemia were found. No association was evident in Acute Lymphoid Leukemia. No negative association with Leukemias were observed.
authors.affiliation: Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela. cvillalobos90@latinmail.com
authors.forename: Carmen
authors.initials: C
authors.lastname: Villalobos
authors.forename: Sergio
authors.initials: S
authors.lastname: Rivera
authors.forename: Jesús
authors.initials: J
authors.lastname: Weir-Medina
authors.forename: Manzur
authors.initials: M
authors.lastname: Hassanhi
authors.forename: Milagros
authors.initials: M
authors.lastname: Montiel
authors.forename: Romer
authors.initials: R
authors.lastname: González
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D005805:Genes, MHC Class I; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D011446:Prospective Studies; D014687:Venezuela