Regulatory (suppressor) T cells in peripheral allograft tolerance and graft-versus-host reaction.
Among the mechanisms capable of inducing peripheral tolerance, regulatory (suppressor) T cells (Treg) probably play a key role in the control of both reactivity to self-antigens and alloimmune response. Augmentation or manipulation of Treg could improve organ allograft survival or control graft-versus-host disease, thus resulting in operational tolerance. The role of this immunomanipulation as one method of inducing tolerance has yet to be clearly defined.
Rifle
Gérard
G
UPRES EA563, Faculté de Médecine, Université de Bourgogne and Department of Nephrology-Intensive Care-Transplantation, Hôpital du Bocage, Dijon, France. gerard.rifle@chu-dijon.fr.
Hervé
Patrick
P
D006086:Graft vs Host Disease / Q000517:prevention & control*; D006087:Graft vs Host Reaction / Q000502:physiology*; D006801:Humans; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*; D023001:Transplantation Tolerance / Q000502:physiology*