title: Structure and pharmacology of swelling-sensitive chloride channels, I(Cl,swell).
abstract: Since several years, the interest for chloride channels and more particularly for the enigmatic swelling-activated chloride channel (I(Cl,swell)) is increasing. Despite its well-characterized electrophysiological properties, the I(Cl,swell) structure and pharmacology are not totally elucidated. These channels are involved in a variety of cell functions, such as cardiac rhythm, cell proliferation and differentiation, cell volume regulation and cell death through apoptosis. This review will consider different aspects regarding structure, electrophysiological properties, pharmacology, modulation and functions of these swelling-activated chloride channels.
authors.affiliation: Laboratoire de Pharmacologie, INSERM E00.01, Faculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: d'Anglemont de Tassigny
authors.forename: Rachid
authors.initials: R
authors.lastname: Souktani
authors.forename: Bijan
authors.initials: B
authors.lastname: Ghaleh
authors.forename: Patrick
authors.initials: P
authors.lastname: Henry
authors.forename: Alain
authors.initials: A
authors.lastname: Berdeaux
mesh_terms: D000818:Animals; D048429:Cell Size / Q000187:drug effects* / Q000502:physiology*; D018118:Chloride Channels / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects* / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology
chemical_list: D018118:Chloride Channels