Competitive, reversible, physiological? Inhibition of mitochondrial cytochrome oxidase by nitric oxide.
In the mid 1990s a number of research groups recognized that mitochondrial oxygen consumption could be reversibly inhibited by nitric oxide at the level of the enzyme cytochrome c oxidase. The inhibition was apparently competitive with respect to the oxygen concentration. This review critically assesses the present state of knowledge as regards the hypothesis that nitric oxide is a competitive, reversible, physiological inhibitor of cytochrome oxidase.
Cooper
Chris E
CE
Department of Biological Sciences, University of Essex, Colchester C04 3SQ, UK. ccooper@essex.ac.uk
D000818:Animals; D004305:Dose-Response Relationship, Drug; D003576:Electron Transport Complex IV / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006454:Hemoglobins / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D008956:Models, Chemical; D009569:Nitric Oxide / Q000378:metabolism*; D010100:Oxygen / Q000737:chemistry / Q000378:metabolism; D010101:Oxygen Consumption
D006454:Hemoglobins; D009569:Nitric Oxide; D003576:Electron Transport Complex IV; D010100:Oxygen