title: Association between a variant of the glutathione S-transferase P1 gene (GSTP1) and hypertension in pregnancy in Japanese: interaction with parity, age, and genetic factors.
abstract: Hypertension in pregnancy (HP), including preeclampsia (PE), is known to be a multifactorial disease. Recently, an Ile105Val variant of the glutathione S-transferase P1 gene ( GSTP1) was shown to be associated with PE in The Netherlands. We therefore performed an association study of the Ile105Val variant comparing 131 patients with HP and 327 normal pregnant controls in Japan. We analyzed the data in the context of other risk factors before pregnancy. The frequency of the Ile/Val+Val/Val genotype of the GSTP1 was not significantly different between the HP (26%) patients and the controls (28%). However, in primiparous patients, the frequency was significantly different in elderly pregnancy (63% in severe HP vs. 18% in controls; P < 0.05), in the subgroup with the MM+MT genotypes of the angiotensinogen gene (50% in severe HP vs. 26% in controls; P < 0.05), and in the subgroup with the GA+AA genotypes of the endothelial nitric oxide synthase gene (42% in severe HP vs. 13% in controls; P < 0.05). These results suggest that this variant of the GSTP1 may play a role in the manifestation of HP together with other independently and/or synergistically acting factors, particularly in primiparous pregnancy.
authors.affiliation: Department of Health for Senior Citizens, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Ohta
authors.forename: Gen
authors.initials: G
authors.lastname: Kobashi
authors.forename: Akira
authors.initials: A
authors.lastname: Hata
authors.forename: Hideto
authors.initials: H
authors.lastname: Yamada
authors.forename: Hisanori
authors.initials: H
authors.lastname: Minakami
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Fujimoto
authors.forename: Kiyotaro
authors.initials: K
authors.lastname: Kondo
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Tamashiro
mesh_terms: D000328:Adult; D000367:Age Factors; D001483:Base Sequence; D017931:DNA Primers; D005260:Female; D006580:Genetic Carrier Screening; D014644:Genetic Variation; D005838:Genotype; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D006973:Hypertension / Q000201:enzymology / Q000235:genetics*; D007527:Isoenzymes / Q000235:genetics*; D008423:Maternal Age; D010298:Parity; D011225:Pre-Eclampsia / Q000201:enzymology / Q000235:genetics; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000201:enzymology*; D018566:Pregnancy, High-Risk; D012016:Reference Values
chemical_list: D017931:DNA Primers; D007527:Isoenzymes; C496556:GSTP1 protein, human; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase