Jud Coon: 35 years of p450 research, a synopsis of p450 history.
The year 2004 marks the 50th anniversary of the discovery of cytochrome P450. Minor J. (Jud) Coon has been a leader in this field for the last 35 years. This review summarizes his contributions to P450 research by discussing six of his most significant publications; not surprisingly, these papers serve as landmarks for the major directions followed in P450 research.
Porter
Todd D
TD
Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536-0082, USA. tporter@uky.edu
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000235:genetics / Q000266:history / Q000502:physiology*; D004790:Enzyme Induction; D005227:Fatty Acids / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans; D058085:Iron Compounds / Q000494:pharmacology; D007527:Isoenzymes / Q000302:isolation & purification; D008862:Microsomes, Liver / Q000201:enzymology; D016296:Mutagenesis / Q000187:drug effects / Q000235:genetics; D009154:Mutation; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism
D005227:Fatty Acids; D058085:Iron Compounds; D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System; D009251:NADPH-Ferrihemoprotein Reductase