title: Decrease of beta-cells and increase of alpha-cells in a diabetic patient with mitochondrial DNA 3243 (A-->G) mutation.
abstract: We report here a case of a 53-year-old woman with mitochondrial 3243 (A-->G) mutation diabetes. Diabetes mellitus was diagnosed at 39 years of age. At 50 years of age, cardiomyopathy and hypothyroidism were noted. At 53 years of age, the patient was admitted to our hospital for treatment of necrotic ulceration of toes. However, she died of massive heart failure. Pathological examination at autopsy showed a decrease in size, number, and acidophilicity of islets in the pancreas. Immunohistochemical stain revealed a decrease in the beta-cell population to 20.5+/-9.2% and a relative increase in alpha-cell population to 48.6+/-11.5%.
authors.affiliation: Department of Internal Medicine, Gifu Central Hospital, Gifu.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kojima
authors.forename: Mayumi
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Naoki
authors.initials: N
authors.lastname: Furuhashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sarui
authors.forename: Hisato
authors.initials: H
authors.lastname: Takatsu
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Takeda
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Ishizuka
authors.forename: Koji
authors.initials: K
authors.lastname: Yamada
authors.forename: Keigo
authors.initials: K
authors.lastname: Yasuda
mesh_terms: D002311:Cardiomyopathy, Dilated / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D003638:Deafness / Q000235:genetics; D003920:Diabetes Mellitus / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000235:genetics; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000378:metabolism*; D008875:Middle Aged; D017354:Point Mutation; D012356:RNA, Transfer, Leu / Q000235:genetics
chemical_list: D004272:DNA, Mitochondrial; D012356:RNA, Transfer, Leu