title: [Experimental research on spontaneous benign prostatic hyperplasia in old dogs].
abstract: OBJECTIVE
  To investigate the pathoanatomize histological and biochemical characteristics of benign prostatic hyperplasia (BPH) by use of old dogs with spontaneous BPH as animal models.
  
  
  METHODS
  Old dogs aged 6 to 13 years were recruited after anus check, B-ultrasonic examination by recta spy and measurement under surgical exploration. Ten dogs with notable prostatic hyperplasia were used as models, and 6 with non-hyperplasia prostate as control. Serum testosterone (T), estrogen (E2), ACP and prostatic specific antigen (PSA) were analyzed, and prostates were checked histologically.
  
  
  RESULTS
  Prostate volume of the BPH group was significantly bigger than those of the control group, (14.7 +/- 2.3) and (13.8 +/- 1.9) cm3 vs (8.4 +/- 1.0) and (8.4 +/- 1.9) cm3, P < 0.01. Serum T [(14.3 +/- 2.9) vs (16.4 +/- 4.0) nmol/L] and E2 [(137.6 +/- 70.8) vs (164.4 +/- 82.0) pmol/L] were not different between the two groups (P > 0.05). ACP of the BPH group was higher than that of the control group [(6.63 +/- 2.76) vs (4.92 +/- 2.19) U/L], but the difference was not statistically significant (P > 0.05). There was significant difference between the BPH group and the control group in PSA level [(5.6 +/- 0.78) vs (3.1 +/- 0.54) microgram/L, P < 0.01]. The tissue slides of the BPH prostates showed hyperplasia with raised height of epithelium, and many long and offsetting mammillae in the gland cavity due to epithelium hyperplasia.
  
  
  CONCLUSIONS
  Old dogs with spontaneous BPH are useful animal models for the etiological and pharmacological researches of human BPH.
authors.affiliation: Jiangsu Family Planning Institute, Nanjing, Jiangsu 210036, China.
authors.forename: Rui-Fen
authors.initials: RF
authors.lastname: Cai
authors.forename: Yu-Gui
authors.initials: YG
authors.lastname: Cui
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Hua
authors.forename: Yue
authors.initials: Y
authors.lastname: Jia
authors.forename: Ding-Zhi
authors.initials: DZ
authors.lastname: Ma
authors.forename: Xing-Hai
authors.initials: XH
authors.lastname: Wang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D008297:Male; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood; D011470:Prostatic Hyperplasia / Q000473:pathology* / Q000662:veterinary*
chemical_list: D017430:Prostate-Specific Antigen