title: Clinical utility and approach to estimate postprandial hypertriglycemia by a newly designed oral fat-loading test.
abstract: The objective of this study was to estimate postprandial hypertriglycemia by a newly designed oral fat-loading test. Twenty-three healthy normolipidemic volunteers were orally administered a test meal consisting of a mixture of Telmeal 2.0 and 20 g of salt-free butter after fasting for 12 h. To measure the levels of total cholesterol (T-Cho), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), remnant-like particle-cholesterol (RLP-C), lipoprotein (a) [Lp (a)], free fatty acid, apolipoproteins (Apos), plasma glucose (PG), immunoreactive insulin (IRI), and high-sensitivity C-reactive protein (hs-CRP), venous blood samples were collected before the meal and at each hour until 9 h after fat-loading. The levels of both TG and RLP-C were drastically elevated at 2 h after fat-loading and these levels remained high until 4 h (p < 0.01). A significant correlation between TG and RLP-C was also observed at 2, 3 and 4 h, and the values of the correlation coefficients (r) were 0.837, 0.838, and 0.908, respectively. In contrast, the levels of T-Cho, HDL-C, Lp (a), Apos, PG, and hs-CRP did not change. Furthermore, there were no gastrointestinal symptoms during or after the study. These results strongly suggested that this newly designed fat-loading test was very useful for evaluating postprandial hypertriglycemia, including remnant concentrations.
authors.affiliation: Department of Laboratory Medicine, Yamagata University School of Medicine, Yamagata, Japan. migarasi@med.id.yamagata-u.ac.jp
authors.forename: Masahiko
authors.initials: M
authors.lastname: Igarashi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Hirata
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Tsuchiya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ohnuma
authors.forename: Yumi
authors.initials: Y
authors.lastname: Jimbu
authors.forename: Yoko
authors.initials: Y
authors.lastname: Okuyama
authors.forename: Toru
authors.initials: T
authors.lastname: Shirata
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Otsu
authors.forename: Haru
authors.initials: H
authors.lastname: Fukuyama
authors.forename: Sachiko
authors.initials: S
authors.lastname: Takahashi
authors.forename: Makoto
authors.initials: M
authors.lastname: Tominaga
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
mesh_terms: D000328:Adult; D001054:Apolipoproteins A / Q000097:blood; D001786:Blood Glucose; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000175:diagnosis*; D007328:Insulin / Q000097:blood; D017270:Lipoprotein(a) / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D019518:Postprandial Period; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
chemical_list: D001054:Apolipoproteins A; D001786:Blood Glucose; D008076:Cholesterol, HDL; D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D017270:Lipoprotein(a); D008074:Lipoproteins; D014280:Triglycerides; C112017:remnant-like particle cholesterol; D002097:C-Reactive Protein; D002784:Cholesterol