title: Acute stress-induced changes in hippocampal/prefrontal circuits in rats: effects of antidepressants.
abstract: Acute stress inhibits long-term potentiation (LTP) at synapses from the hippocampus to prefrontal cortex in the rat, a model of the dysfunction in the anterior cingulate/orbitofrontal cortices which has been observed in human depression. We demonstrate that the antidepressants tianeptine and, to a lesser extent, fluoxetine, are able to reverse the impairment in LTP, a measure of frontal synaptic plasticity, caused by stress on an elevated platform. LTP was induced by stimulation of hippocampal outflow. Beneficial effects on neuronal plasticity, defined as a reversal of the effects of stress in this paradigm, can be considered as a new animal model for the impact of stress on hippocampal/frontal circuits, a key target in psychiatric diseases.
authors.affiliation: NAMC, CNRS UMR 8620, Bat. 446, Université Paris-Sud, 91405 Orsay, France.
authors.forename: Cyril
authors.initials: C
authors.lastname: Rocher
authors.forename: Michael
authors.initials: M
authors.lastname: Spedding
authors.forename: Carmen
authors.initials: C
authors.lastname: Munoz
authors.forename: Thérèse M
authors.initials: TM
authors.lastname: Jay
mesh_terms: D000208:Acute Disease; D000818:Animals; D005473:Fluoxetine / Q000008:administration & dosage* / Q000627:therapeutic use; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D007274:Injections, Intraperitoneal; D017774:Long-Term Potentiation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological / Q000188:drug therapy / Q000503:physiopathology*; D013841:Thiazepines / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D013841:Thiazepines; D005473:Fluoxetine; C050504:tianeptine