title: In silico prediction of the structure of membrane proteins: is it feasible?
abstract: In the 'omic' era, hundreds of genomes are available for protein sequence analysis, and some 30 per cent of all sequences are of membrane proteins. Unlike globular proteins, a 3D model for membrane proteins can hardly be computed starting from the sequence. Why is this so? What can we really compute and with what reliability? These and other matters are outlined.
authors.affiliation: Laboratory of Biocomputing, CIRB/Department of Biology, University of Bologna, Via Irnerio 42, 40126 Bologna, Italy. casadio@alma.unibo.it
authors.forename: Rita
authors.initials: R
authors.lastname: Casadio
authors.forename: Piero
authors.initials: P
authors.lastname: Fariselli
authors.forename: Pier Luigi
authors.initials: PL
authors.lastname: Martelli
mesh_terms: D019295:Computational Biology; D008565:Membrane Proteins / Q000737:chemistry*; D008958:Models, Molecular; D017434:Protein Structure, Tertiary; D020539:Sequence Analysis, Protein
chemical_list: D008565:Membrane Proteins