title: Immunization with ACE (Angiotensin Converting Enzyme) develops diabetic changes in the kidney and retina in diabetogenic rats.
abstract: In normal New Zealand white rabbits, immunization with rabbit lung ACE (angiotensin converting enzyme) induced atherosclerotic retinal changes, and glomerular changes similar to those seen in diabetic nephropathy. Also, in genetically diabetogenic rats, immunization with the rabbit lung ACE induced diabetic nephropathy and retinopathy.
authors.affiliation: Division of Endocrinology, Department of Medicine, Kawasaki Medical School, Okayama, Japan.
authors.forename: Seikoh
authors.initials: S
authors.lastname: Nishida
authors.forename: Tamaki
authors.initials: T
authors.lastname: Sasaki
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kimura
authors.forename: Junji
authors.initials: J
authors.lastname: Tanaka
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nohno
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Hirokawa
authors.forename: Michihiro
authors.initials: M
authors.lastname: Matsuki
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ichihara
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis; D001161:Arteriosclerosis / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000276:immunology / Q000473:pathology; D003928:Diabetic Nephropathies / Q000276:immunology* / Q000473:pathology*; D003930:Diabetic Retinopathy / Q000276:immunology* / Q000473:pathology*; D005260:Female; D007114:Immunization; D007678:Kidney Glomerulus / Q000473:pathology; D008168:Lung / Q000737:chemistry; D007703:Peptidyl-Dipeptidase A / Q000276:immunology* / Q000302:isolation & purification; D011817:Rabbits; D051381:Rats; D020334:Rats, Inbred OLETF; D011919:Rats, Inbred Strains; D012160:Retina / Q000473:pathology
chemical_list: D000906:Antibodies; D007703:Peptidyl-Dipeptidase A