title: Fluoroquinolone resistance linked to GyrA, GyrB, and ParC mutations in Salmonella enterica typhimurium isolates in humans.
abstract: We report two cases of infection with clonally unrelated, high-level ciprofloxacin-resistant, b-lactamase-producing strains of Salmonella enterica Typhimurium. Resistance was caused by four topoisomerase mutations, in GyrA, GyrB, and ParC and increased drug efflux. Ciprofloxacin treatment failed in one case. In the second case, reduced susceptibility to third-generation cephalosporins occurred after initial treatment with these drugs and may explain the treatment failure with ceftriaxone.
authors.affiliation: Hõpital Saint-Louis, Université Paris VII, Paris, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Casin
authors.forename: Jacques
authors.initials: J
authors.lastname: Breuil
authors.forename: Jean Pierre
authors.initials: JP
authors.lastname: Darchis
authors.forename: Claire
authors.initials: C
authors.lastname: Guelpa
authors.forename: Ekkehard
authors.initials: E
authors.lastname: Collatz
mesh_terms: D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D027081:DNA Gyrase / Q000187:drug effects / Q000235:genetics*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D024841:Fluoroquinolones / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D012480:Salmonella Infections / Q000188:drug therapy*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; D027081:DNA Gyrase