title: Enantioselective access to 2,7-cis-disubstituted oxepanes: formal synthesis of (+)-isolaurepan.
abstract: [reaction: see text] The asymmetric synthesis of 2,7-cis-disubstituted oxepanes bearing a sulfoxide is achieved from commercially available precursors in only five steps. The key step is the highly diastereoselective Et3SiH/TMSOTf-promoted reductive cyclization of enantiopure hydroxysulfinyl aryl or alkyl ketones.
authors.affiliation: Departamento de Química Orgánica (C-I), Universidad Autónoma de Madrid, Cantoblanco, 28049-Madrid, Spain. carmen.carrenno@uam.es
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Carreño
authors.forename: Renaud
authors.initials: R
authors.lastname: Des Mazery
authors.forename: Antonio
authors.initials: A
authors.lastname: Urbano
authors.forename: Françoise
authors.initials: F
authors.lastname: Colobert
authors.forename: Guy
authors.initials: G
authors.lastname: Solladié