title: Synthesis of hexahydropyridazine-3-phosphonic acid.
abstract: The synthesis of hexahydropyridazine-3-phosphonic acid (piperidazine-3-phosphonic acid) was performed via a hetero-Diels-Alder reaction followed by Lewis acid-catalyzed phosphonylation. This two-step procedure was improved to a one-pot reaction.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokuriku University, Kanagawa-machi Ho-3, Kanazawa 920-1181, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Kaname
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yoshinaga
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Arakawa
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Yoshifuji
mesh_terms: D002384:Catalysis; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry*; D011724:Pyridazines / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
chemical_list: D007202:Indicators and Reagents; D063065:Organophosphonates; D011724:Pyridazines; C488486:hexahydropyridazine-3-phosphonic acid