title: Simultaneously evaluating the effects of one-week fluticasone propionate inhalation therapy on lung ventilation and permeability in children with asthma.
abstract: This study evaluated the effects of fluticasone propionate inhalation therapy on lung ventilation and alveolar permeability by quantitative Tc-99m DTPA radioaerosol inhalation lung scintigraphy in 15 children with asthma. Lung ventilation was evaluated as the distribution percentage (D%) of Tc-99m DTPA radioaerosols in the central, intermediate and peripheral regions of the right lung. Alveolar permeability was measured by the rate of Tc-99m DTPA radioaerosol clearance curve from the peripheral alveoli of the right lung and represented as slope. The D% and slopes were calculated before and after one-week inhalation therapy (100 microg fluticasone propionate two times daily for one-week) to evaluate the effects of inhalation therapy on lung ventilation and alveolar permeability. The preliminary results revealed statistically significantly improved lung ventilation but no significant change of alveolar permeability in the right lung after one-week fluticasone propionate inhalation therapy in children with asthma. We suggest that the widely available and noninvasive Tc-99m DTPA radioaerosol inhalation lung scintigraphy can simultaneously evaluate lung ventilation and alveolar permeability in one study and should contribute to any disorder involving both alveoli and airways.
authors.affiliation: Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan.
authors.forename: A C
authors.initials: AC
authors.lastname: Chen
authors.forename: F J
authors.initials: FJ
authors.lastname: Tsai
authors.forename: C H
authors.initials: CH
authors.lastname: Tsai
authors.forename: C C
authors.initials: CC
authors.lastname: Lin
authors.forename: C C
authors.initials: CC
authors.lastname: Lee
authors.forename: C H
authors.initials: CH
authors.lastname: Kao
mesh_terms: D000293:Adolescent; D000730:Androstadienes / Q000008:administration & dosage / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001249:Asthma / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D000068298:Fluticasone; D006801:Humans; D008297:Male; D011650:Pulmonary Alveoli / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012123:Pulmonary Ventilation / Q000187:drug effects*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D016284:Technetium Tc 99m Pentetate
chemical_list: D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D019275:Radiopharmaceuticals; D000068298:Fluticasone; D016284:Technetium Tc 99m Pentetate