title: Endotension is influenced by aneurysm volume: experimental findings.
abstract: OBJECTIVE
  To investigate in an in vitro model whether and to what extent pressure is influenced by aneurysm size.
  
  
  METHODS
  Latex aneurysms of 3 different volumes (24, 30, and 81 mL) were inserted into an in vitro circulation model. The systemic mean pressure (SP(mean)) was varied from 50 to 120 mmHg. The aneurysms were excluded using a woven polyethylene graft. Aneurysm sac mean pressure (ASP(mean)) was measured.
  
  
  RESULTS
  In the in vitro model, endovascular aneurysm repair created a closed chamber without endoleak but showed a relevant aneurysm sac pressure. At an SP(mean) of 80 mmHg, the ASP(mean) was 42.0+/-0.6 mmHg in the 24-mL aneurysm, 40.5+/-0.5 mmHg in the 30-mL model, and 19.3+/-0.5 mmHg in the 81-mL aneurysm (p<0.05). The ASP(mean) rose with increasing SP(mean) and was inversely dependent on the aneurysm volume.
  
  
  CONCLUSIONS
  This in vitro model demonstrated that the sac mean pressure correlated to the systemic pressure and that a greater aneurysm volume reduced aneurysm sac pressure. These data highlight the need for further studies regarding endotension.
authors.affiliation: Division of Vascular Surgery, Department of Surgery, Medical Centre, University of Cologne, Germany. Michael.gawenda@medizin.uni-koeln.de
authors.forename: Michael
authors.initials: M
authors.lastname: Gawenda
authors.forename: Stefan
authors.initials: S
authors.lastname: Winter
authors.forename: Gregor
authors.initials: G
authors.lastname: Jaschke
authors.forename: Gernot
authors.initials: G
authors.lastname: Wassmer
authors.forename: Jan
authors.initials: J
authors.lastname: Brunkwall
mesh_terms: D000704:Analysis of Variance; D001014:Aortic Aneurysm / Q000503:physiopathology* / Q000628:therapy*; D021721:Balloon Occlusion / Q000379:methods*; D066298:In Vitro Techniques; D007840:Latex; D008955:Models, Cardiovascular; D011312:Pressure; D011336:Probability; D011673:Pulsatile Flow; D012680:Sensitivity and Specificity
chemical_list: D007840:Latex