title: Intakes of plant foods, fibre and fat and risk of breast cancer--a prospective study in the Malmö Diet and Cancer cohort.
abstract: The objective of this study was to investigate prospectively the associations between intakes of plant foods, fibre and relative fat and risk of breast cancer in a subsample of 11 726 postmenopausal women in the Malmö Diet and Cancer cohort. Data were obtained by an interview-based diet history method, a structured questionnaire, anthropometrical measurements and national and regional cancer registries. During 89 602 person-years of follow-up, 342 incident cases were documented. Cox regression analysis examined breast cancer risks adjusted for potential confounders. High fibre intakes were associated with a lower risk of postmenopausal breast cancer, incidence rate ratio=0.58, 95% CI: 0.40, 0.84, for the highest quintile of fibre intake compared to the lowest quintile. The combination high fibre-low fat had the lowest risk when examining the effect in each cell of cross-classified tertiles of fibre and fat intakes. An interaction (P=0.049) was found between fibre- and fat-tertiles. There was no significant association between breast cancer risk and intakes of any of the plant food subgroups. These findings support the hypothesis that a dietary pattern characterised by high fibre and low fat intakes is associated with a lower risk of postmenopausal breast cancer.
authors.affiliation: Department of Medicine, Surgery and Orthopaedics, Lund University, Malmö University Hospital, SE-205 02 Malmö, Sweden. irene.mattisson@smi.mas.lu.se
authors.forename: I
authors.initials: I
authors.lastname: Mattisson
authors.forename: E
authors.initials: E
authors.lastname: Wirfält
authors.forename: U
authors.initials: U
authors.lastname: Johansson
authors.forename: B
authors.initials: B
authors.lastname: Gullberg
authors.forename: H
authors.initials: H
authors.lastname: Olsson
authors.forename: G
authors.initials: G
authors.lastname: Berglund
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000208:ethnology / Q000517:prevention & control*; D015331:Cohort Studies; D004041:Dietary Fats; D004043:Dietary Fiber; D005006:Ethnicity; D005260:Female; D006801:Humans; D008875:Middle Aged; D010945:Plants, Edible; D017698:Postmenopause; D012042:Registries / Q000706:statistics & numerical data*; D012044:Regression Analysis; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology / Q000208:ethnology
chemical_list: D004041:Dietary Fats; D004043:Dietary Fiber