title: Granulomatous slack skin without evidence of a clonal T-cell proliferation.
abstract: Granulomatous slack skin is a rare cutaneous disorder with less than 50 cases presented in the English-language literature. The disease is characterized by circumscribed erythematous lax skin accentuated most commonly in the axillary and inguinal areas. A strong association with a preceding or evolving diagnosis of mycosis fungoides or Hodgkin's disease has been reported. Previous reports describe the entity as a lymphoproliferative disease in the same spectrum as mycosis fungoides and Hodgkin's disease with a monoclonal T-cell population. Our case, without an evident beta-T-cell receptor rearrangement, suggests that not all cases of granulomatous slack skin are a result of an indolent lymphoma. Granulomatous slack skin probably represents a spectrum of diseases that can eventuate into a lymphoproliferative process.
authors.affiliation: Department of Medicine, Division of Dermatology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
authors.forename: Joseph
authors.initials: J
authors.lastname: Gadzia
authors.forename: Thelda
authors.initials: T
authors.lastname: Kestenbaum
mesh_terms: D000328:Adult; D001365:Axilla; D003937:Diagnosis, Differential; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D006099:Granuloma / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D008297:Male; D012507:Sarcoidosis / Q000175:diagnosis; D012871:Skin Diseases / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology