title: Trypanocidal constituents in plants 3. Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense.
abstract: The constituents of the leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense were investigated based on their trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent of Chagas' disease. As the active components, the polyisoprenylated benzophenone derivative guttiferone A and the xanthone 8-desoxygartanin were isolated along with the biflavonoids podocarpusflavone A and amentoflavone, and friedelin from the former. Three xanthones, jacareubin, 6-deoxyjacareubin, and 1,3,5,6-tetrahydroxy-2-(3-methyl-2-butenyl)xanthone from the latter showed activity. The trypanocidal activity of these compounds against trypomastigotes, an infectious form of T. cruzi, was examined as well as gossypol, berberine chloride, and harmine for comparison.
authors.affiliation: Faculty of Pharmaceutical Sciences, School of Medicine, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. abefumi@fukuoka-u.ac.jp
authors.forename: Fumiko
authors.initials: F
authors.lastname: Abe
authors.forename: Shinya
authors.initials: S
authors.lastname: Nagafuji
authors.forename: Hikaru
authors.initials: H
authors.lastname: Okabe
authors.forename: Hiroshige
authors.initials: H
authors.lastname: Akahane
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Estrada-Muñiz
authors.forename: Maira
authors.initials: M
authors.lastname: Huerta-Reyes
authors.forename: Ricardo
authors.initials: R
authors.lastname: Reyes-Chilpa
mesh_terms: D000818:Animals; D001599:Berberine / Q000494:pharmacology; D029759:Calophyllum / Q000737:chemistry*; D029760:Garcinia / Q000737:chemistry*; D006072:Gossypol / Q000494:pharmacology; D006247:Harmine / Q000494:pharmacology; D007202:Indicators and Reagents; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D014344:Trypanocidal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects; D014934:Wood
chemical_list: D007202:Indicators and Reagents; D010936:Plant Extracts; D014344:Trypanocidal Agents; D001599:Berberine; D006247:Harmine; D006072:Gossypol