title: Sonographic and scintigraphic evaluation of acute renal allograft rejection in cats.
abstract: The sonographic features of acute renal allograft rejection in humans and dogs are manifested by increase in renal cross-sectional area and reduction in renal cortical blood flow. These changes have not been investigated in cats. The objectives of this study were to evaluate sonographic and scintigraphic changes during acute renal allograft rejection in cats. Eight SPF, intact, adult, male cats received heterotopic renal allotransplantations. Immunosuppressive doses of cyclosporine and prednisolone were administered for 14 days and then discontinued to allow acute allograft rejection to occur. Serial measurements of renal cross-sectional area, resistive index (RI), echogenicity, and glomerular filtration rate (GFR) were performed to evaluate changes during acute rejection. Upon sonographic confirmation of absent diastolic blood flow or a 20% increase in cross-sectional area of the allograft, a nephrectomy and histopathologic evaluation were performed. Acute allograft rejection was confirmed histologically in all cats. Significant increases in renal cross-sectional area (P < 0.001) occurred postoperatively and during rejection. There were no significant changes in RI (P = 0.43) at any time. A subjective increase in medullary echogenicity and a decrease in corticomedullary demarcation were observed in the rejection period. While GFR decreased significantly in the immediate postoperative period (P < 0.001), no further change occurred during rejection (P = 0.42). Changes in RI and GFR do not appear to be sensitive indicators of acute renal allograft rejection in cats. Serial measurements of renal cross-sectional area appear to be a sensitive method for the early diagnosis of allograft rejection in feline renal transplant recipients.
authors.affiliation: Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
authors.forename: Krista B
authors.initials: KB
authors.lastname: Halling
authors.forename: John P
authors.initials: JP
authors.lastname: Graham
authors.forename: Susan P
authors.initials: SP
authors.lastname: Newell
authors.forename: Gary W
authors.initials: GW
authors.lastname: Ellison
authors.forename: Carol J
authors.initials: CJ
authors.lastname: Detrisac
authors.forename: Frank G
authors.initials: FG
authors.lastname: Martin
authors.forename: James M
authors.initials: JM
authors.lastname: VanGilder
authors.forename: Daniel
authors.initials: D
authors.lastname: Grossman
mesh_terms: D000818:Animals; D002415:Cats; D005919:Glomerular Filtration Rate / Q000662:veterinary; D006084:Graft Rejection / Q000662:veterinary*; D007668:Kidney / Q000098:blood supply* / Q000000981:diagnostic imaging; D007677:Kidney Function Tests / Q000379:methods / Q000662:veterinary; D016030:Kidney Transplantation / Q000662:veterinary*; D008297:Male; D011877:Radionuclide Imaging / Q000662:veterinary; D012079:Renal Circulation; D013047:Specific Pathogen-Free Organisms; D016284:Technetium Tc 99m Pentetate; D014463:Ultrasonography / Q000662:veterinary
chemical_list: D016284:Technetium Tc 99m Pentetate