Association of MHC class II-peptide complexes with plasma membrane lipid microdomains.
Activation of CD4(+) T cells requires the interaction of multiple T-cell receptors with MHC class II-peptide complexes on the surface of antigen-presenting cells (APCs). Recent studies have shown that MHC class II complexes are clustered in APC plasma membrane microdomains, thereby providing a mechanism for localized concentration of MHC class II-peptide complexes. The integrity of one type of APC membrane microdomain, the lipid raft, is important for antigen presentation to T cells. We propose a model in which the coordinated processes of MHC class II peptide loading and intracellular trafficking enhance T-cell activation by loading specific MHC class II-peptide complexes in discrete lipid raft microdomains.
Poloso
Neil J
NJ
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Roche
Paul A
PA
D000818:Animals; D017951:Antigen Presentation; D015704:CD4 Antigens / Q000502:physiology; D000949:Histocompatibility Antigens Class II / Q000502:physiology*; D021962:Membrane Microdomains / Q000276:immunology*; D008565:Membrane Proteins / Q000378:metabolism; D018448:Models, Immunological; D010455:Peptides / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology
D015704:CD4 Antigens; D000949:Histocompatibility Antigens Class II; D008565:Membrane Proteins; D010455:Peptides