title: Immunohistochemical mucin expression of short-segment Barrett's esophagus.
abstract: Barrett's mucosa consists of metaplastic columnar epithelium (specialized columnar epithelium) of the esophagus. Recently, "short-segment Barrett's esophagus (SSBE)" was proposed. In the present study, we examined immunohistochemical mucin expression and the Ki-67 labeling index (LI) of SSBE, in 5-15 mm lengths. All 27 SSBE cases showed gastric mucin (MUC5AC, HGM, MUC6). CD10 and MUC2, which were markers of intestinal phenotypes, were detected in 13 (48.1%) and 14 (51.9%) of the 27 SSBE cases. Ki-67 LI of SSBE positive cases for CD10 was 23.6 %, while that of SSBE negative cases for CD10 was 14.4 % (p < 0.05). SSBE cases were divided into two groups: one was gastric epithelium type with low Ki-67 LI, and the other was metaplastic epithelium with intestinal metaplasia and high Ki-67 LI. The latter group was suggested to be more important as a premalignant lesion of esophageal adenocarcinoma.
authors.affiliation: Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
authors.forename: Soichiro
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kijima
authors.forename: Tadashi
authors.initials: T
authors.lastname: Hara
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kenmochi
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kise
authors.forename: Hikaru
authors.initials: H
authors.lastname: Tanaka
authors.forename: Osamu
authors.initials: O
authors.lastname: Chino
authors.forename: Hideo
authors.initials: H
authors.lastname: Shimada
authors.forename: Makiko
authors.initials: M
authors.lastname: Tanaka
authors.forename: Sadaki
authors.initials: S
authors.lastname: Inokuchi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Makuuchi
mesh_terms: D001471:Barrett Esophagus / Q000378:metabolism* / Q000473:pathology; D005753:Gastric Mucosa / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007413:Intestinal Mucosa / Q000737:chemistry / Q000473:pathology; D019394:Ki-67 Antigen / Q000032:analysis; D008679:Metaplasia; D055262:Mucin-2; D009077:Mucins / Q000032:analysis*; D015260:Neprilysin / Q000032:analysis; D013194:Staining and Labeling
chemical_list: D019394:Ki-67 Antigen; C524625:MUC2 protein, human; D055262:Mucin-2; D009077:Mucins; D015260:Neprilysin