Transmembrane signalling by integrins.
Recent work has shown that integrin receptors serve not only as structural receptors that connect the extracellular matrix to the cytoskeleton, but also as signalling receptors that regulate intracellular pH, intracellular free calcium, phosphorylation of proteins on tyrosine and inositol lipid turnover. The ability of extracellular matrix to influence growth, differentiation and other cell functions is very likely related to their effects on signaling pathways inside the cell.
Schwartz
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The Scripps Research Institute Committee on Vascular Biology, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA.