title: [Study on injectable bioactive bone repairing material of nano-hydroxyapatite and polyamide-66 composite].
abstract: The aim of this study was to evaluate the injectability, histocompatibility, function and other properties of the injectable bioactive bone repairing material of nano-hydroxyapatite and polyamide-66 (n-HA/PA66) composite. The XRD pattern, the relationship between the injectability and liquid-powder ratio, setting time and liquid-powder ratio, compressive strength and liquid-powder ratio were assessed. The size of the composite was determined to be 70 nm in length and 30 to 50 nm in width, and the molecular weight of polyamides-66 was 18000. The diameter of pores of the composite was about 200 to 400 micrometer. To evaluate the histocompatibility and function, 8 male dogs were studied with the injectable n-HA/PA66 composite implanted in the artificial defected alveolus of mandible on only one side to be compared with the intact alveolus on the other side. The specimens were taken at 4, 8, 12, 16 months after the implantation and the results were evaluated. The XRD pattern of the solidificated n-HA/PA66 composite was the same as the powdered n-HA/PA66 composite. The injectable n-HA/PA66 composite had a good injectability, 25 to 30 minutes setting time and about 37 MPa compressive strength when the liquid-powder ratio was 0.50. The healing of the gingiva was well at the implanted areas in all animals. The height of the repaired alveolar bone was obvious higher than that of the blank control. The earlier sign of ossification was histologically observed at 16 weeks after implantation. The injectable n-HA/PA66 composite has good biocompatibility and osteoconductive property. As an injectable material, with good maneuverability, it is useful for repairing irregular bone defects, especially in oral and maxillofacial surgery.
authors.affiliation: West China College of Stomatology, Sichuan University, Chengdu 610041.
authors.forename: Shicheng
authors.initials: S
authors.lastname: Wei
authors.forename: Yubao
authors.initials: Y
authors.lastname: Li
authors.forename: Qian
authors.initials: Q
authors.lastname: Zheng
authors.forename: Jie
authors.initials: J
authors.lastname: Wei
authors.forename: Liwei
authors.initials: L
authors.lastname: Zhou
authors.forename: Yi
authors.initials: Y
authors.lastname: Zuo
mesh_terms: D000539:Alveolar Process / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D018786:Bone Substitutes / Q000008:administration & dosage / Q000494:pharmacology; D004285:Dogs; D017886:Durapatite; D007267:Injections; D008297:Male; D008422:Materials Testing; D009757:Nylons; D019919:Prosthesis Implantation / Q000379:methods; D014961:X-Ray Diffraction
chemical_list: D018786:Bone Substitutes; D009757:Nylons; D017886:Durapatite