cADPR analogues: effect of an adenosine 2'- or 3'-methoxy group on conformation.
[structure: see text] The 2'-OMe-A (2) and 3'-OMe-A (3) analogues of the calcium release agent cADPR (1) were prepared and their solution structures studied by NMR spectroscopy. Compared to 1, 2 shows a shift in its A ring conformation and changes in its R ring N:S and gammat:gamma+ ratios, while 3 displays a significant change in the conformation of its A ring gamma-bond.
Graham
Steven M
SM
Department of Chemistry, St. John's University, Jamaica, New York 11439, USA. grahams@stjohns.edu
Macaya
Daniel J
DJ
Sengupta
Raghuvir N
RN
Turner
Kevin B
KB
D000241:Adenosine / Q000031:analogs & derivatives / Q000737:chemistry*; D036563:Cyclic ADP-Ribose / Q000031:analogs & derivatives* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012996:Solutions / Q000737:chemistry
D012996:Solutions; D036563:Cyclic ADP-Ribose; D000241:Adenosine