title: Isomorphic response after saphenectomy in a patient with granuloma annulare.
abstract: Physical trauma has been reported as an etiologic factor of granuloma annulare, resembling a Koebner phenomenon. Moreover, granuloma annulare frequently arises at the same location of a previously healed, unrelated skin disease, mainly herpetic infection. These data seem to suggest that granuloma annulare might be a peculiar pattern of skin reaction to different stimuli, either physical or biologic, in predisposed subjects. In the case reported herein, the onset of a typical lesion of granuloma annulare at the site of saphenectomy might be explained as the result of an aberrant wound healing process, with release, by keratinocytes and/or Langerhans cells, of lymphocyte-derived chemotactic cytokines, capable of promoting the development of the granulomatous lesion.
authors.affiliation: Institute of Dermatology, University of Messina, Via Consolare Valeria, Gazzi, 98125 Messina, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Borgia
authors.forename: Serafinella P
authors.initials: SP
authors.lastname: Cannavò
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Guarneri
authors.forename: Carolina
authors.initials: C
authors.lastname: Manfrè
authors.forename: Mario
authors.initials: M
authors.lastname: Vaccaro
mesh_terms: D003924:Diabetes Mellitus, Type 2; D003937:Diagnosis, Differential; D005121:Extremities; D016460:Granuloma Annulare / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged