Executing cell senescence.
Senescence is a permanent form of cell cycle arrest that limits the proliferation of damaged cells and may contribute to tumor suppression and aging. We recently demonstrated that some senescent cell types undergo dramatic changes in chromatin organization that are dependent on the retinoblastoma protein and are associated with the stable repression of some E2F target genes. Here we show how these changes might contribute to the stability of the senescent state.
Narita
Masashi
M
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Lowe
Scott W
SW
D000818:Animals; D016922:Cellular Senescence / Q000502:physiology*; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D016147:Genes, Tumor Suppressor; D006801:Humans; D016160:Retinoblastoma Protein / Q000378:metabolism
D002843:Chromatin; D016160:Retinoblastoma Protein