[General pharmacology of koumine parenteral solution].
OBJECTIVE
To determine the effect of koumine parenteral solution on the nervous, respiratory and cardiovascular systems of experimental animals.


METHODS
Mouse spontaneous activities under the influence of the koumine injection were recorded with a photoelectric counter, and canine femoral artery pressure was determined by CYS-0.5 pressure transducer, respiratory curve described with TB-611 tension transducer and electrocardiogram (ECG) recorded with subcutaneous electrodes in the extremities after the injection. The above indices were automatically sampled and processed by multifunctional signal processor after being inputt to a computer. In this experiment, we observed the changes in the general behavior of the mice and their spontaneous activities within 15 min, along with the heart rate, maximum, minimum, and mean value of cardiac electric voltage, mean arterial pressure, respiratory rate and respiratory depth of the dogs before and at 10, 20, 30, 60, 90, 120 min after koumine injection.


RESULTS
Koumine injection significantly decreased mouse spontaneous activities in moderate and high-dose groups, but did not produce obvious effect on the respiratory system, mean arterial pressure, and maximum, minimum, and mean values of cardiac electric voltage in dogs. The heart rate of the dogs did not undergo obvious changes in response to the injection at a low dose, but median and high doses of the injection produced obvious effects.


CONCLUSIONS
Koumine injection has definite sedative effect in mice, and does not affect the respiratory and cardiovascular systems of dogs with the exception of the heart rate.
Chi
De-biao
DB
Department of Pharmacology, First Military Medical University, Guangzhou 510515, China. chidb666@yahoo.com
Lei
Lin-sheng
LS
Yang
Hong-xuan
HX
Sun
Li-sa
LS
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D031450:Gelsemium / Q000737:chemistry*; D006339:Heart Rate / Q000187:drug effects; D007267:Injections; D008297:Male; D051379:Mice; D012119:Respiration / Q000187:drug effects