[Analysis of Bsm I polymorphism of the vitamin D receptor (VDR) gene in Venezuelan female patients living in the state of Zulia with osteoporosis].
Among genes implied on the osteoporosis genetics, the most studied gene worldwide is the receptor gene of D vitamin (VDR), through the characterization of Bsm I polymorphism. The main objective of this research was to analyze the Bsm I polymorphism of the VDR gene in a sample of 133 postmenopausal women distributed in three groups: 54 with osteoporosis, 24 with osteopenia and 55 normal controls for the disease. 28 of the women with osteoporosis presented the BB genotype, which is related in other countries to bone mineral density decrease, 20 had the Bb genotype, and 6 the bb genotype. Of the control group only 11 women presented the BB genotype, 36 showed the heterozygote genotype and 8 the bb genotype. The frequencies of the B and b alleles in the analyzed population were 0.6 and 0.4 respectively. The BB genotype was found in 52% of the group with osteoporosis, and in 20% of the control group, these findings are statistically significant, which suggest an association between the BB genotype and osteoporosis.
Borjas-Fajardo
Lisbeth
L
Laboratorio de Genética Molecular, Unidad de Genética Médica, Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela. lisbor@iamnet.com
Zambrano
Mariana
M
Fernández
Erika
E
Pineda
Lennie
L
Machín
Alisandra
A
de Romero
Pilar
P
Zabala
William
W
Sánchez
María Alejandra
MA
Chacín
José Antonio
JA
Delgado
Wilmer
W
D005260:Female; D006801:Humans; D008875:Middle Aged; D009077:Mucins / Q000235:genetics*; D010024:Osteoporosis / Q000235:genetics*; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D014687:Venezuela
C115439:BSM1 protein, Bos taurus; D009077:Mucins; D018167:Receptors, Calcitriol