title: [A study of aspermia-related genes by genchips and analysis of the RAP1A gene].
abstract: OBJECTIVE
  To study the differential gene expression profiles between the normal and aspermia human testes by genechips.
  
  
  METHODS
  Probes were prepared from mRNA extracted from both normal and aspermia testes and employed on Biostar H-40s genechips to detect the differential gene expression profiles. A distinctly up-regulated gene RAP1A was analyzed by bibliogrphic retrieval.
  
  
  RESULTS
  Six hundred and twenty-three differential expressed genes were found, among which the distinctly up-regulated gene RAP1A was closely related to human sperm regulation.
  
  
  CONCLUSIONS
  Screening the differential gene expression profiles between the normal and aspermia human testes by genechips can be used in the study of aspermia-related genes.
authors.affiliation: Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Xiao-Kang
authors.initials: XK
authors.lastname: Gao
authors.forename: He
authors.initials: H
authors.lastname: Wang
authors.forename: He-Liang
authors.initials: HL
authors.lastname: Liu
authors.forename: Bao-Qi
authors.initials: BQ
authors.lastname: Chen
authors.forename: Jian-Lin
authors.initials: JL
authors.lastname: Yuan
authors.forename: Guo-Xing
authors.initials: GX
authors.lastname: Shao
authors.forename: Chen
authors.initials: C
authors.lastname: Shao
mesh_terms: D000328:Adult; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D009845:Oligospermia / Q000235:genetics*; D020827:rap1 GTP-Binding Proteins / Q000235:genetics*
chemical_list: D020827:rap1 GTP-Binding Proteins