Characterization of pathogenic Escherichia coli in human immunodeficiency virus-related diarrhea in Senegal.
Stool samples obtained from 594 Senegalese patients were examined for characterization of pathogenic Escherichia coli in human immunodeficiency virus (HIV)-related diarrhea. Multiple virulence genes were observed in stool samples obtained from HIV-infected patients with diarrhea. Enteroaggregative E. coli and enteroinvasive E. coli were present in stool samples obtained from patients with diarrhea significantly more often than in stool samples obtained from patients without diarrhea (P=.000001). Quinolones may be an effective alternative treatment for E. coli-related diarrhea in HIV-infected adults in Senegal.
Gassama-Sow
Amy
A
Laboratoire de Bactériologie Expérimentale, Institut Pasteur, Dakar, Sénégal. gassama@pasteur.sn
Sow
Papa S
PS
Guèye
Madoumbé
M
Guèye-N'diaye
Aïssatou
A
Perret
Jean L
JL
M'boup
Souleymane
S
Aïdara-Kane
Awa
A
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001422:Bacterial Adhesion / Q000187:drug effects; D016022:Case-Control Studies; D002648:Child; D003967:Diarrhea / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000150:complications* / Q000453:epidemiology; D005243:Feces / Q000382:microbiology; D005798:Genes, Bacterial / Q000187:drug effects; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D015498:HIV-2; D006801:Humans; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D015363:Quinolones / Q000494:pharmacology; D012307:Risk Factors; D012675:Senegal / Q000453:epidemiology; D014774:Virulence / Q000235:genetics*; D037521:Virulence Factors / Q000032:analysis / Q000235:genetics
D000900:Anti-Bacterial Agents; D015363:Quinolones; D037521:Virulence Factors