title: Development and progression of a Philadelphia-chromosome-negative acute myelocytic leukemia clone in a patient with Philadelphia-chromosome-positive chronic myelocytic leukemia.
abstract: We report a patient with typical Philadelphia-chromosome-positive chronic myelocytic leukemia who developed Philadelphia-chromosome-negative acute myelocytic leukemia following autologous stem cell transplantation. The implications of this observation for disease monitoring and treatment are discussed.
authors.affiliation: Hematological Malignancy Diagnostic Service and Regional Cytogenetics Unit, Leeds Teaching Hospitals, Leeds General Infirmary, LS1 3EX Leeds, UK. mattcullen@hmds.org.uk
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Cullen
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Richards
authors.forename: Helen
authors.initials: H
authors.lastname: Dickinson
authors.forename: Chris
authors.initials: C
authors.lastname: Carter
authors.forename: David M
authors.initials: DM
authors.lastname: Swirsky
authors.forename: Roger G
authors.initials: RG
authors.lastname: Owen
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D001549:Benzamides; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D033581:Stem Cell Transplantation
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate