title: Association between major depressive disorder and the -1438A/G polymorphism of the serotonin 2A receptor gene.
abstract: This study investigated the possible effect of the -1438A/G single-nucleotide polymorphism in the promoter region of the serotonin 2A receptor (5-HTR2A) gene on major depressive disorder (MDD) in a Korean population. This polymorphism was analyzed in 189 patients with MDD and in 148 unrelated healthy controls using a case-control design, which revealed a significant difference in the genotype distributions (chi(2) = 10.78, d.f. = 2, p = 0.005). The frequency of the -1438G allele was also much higher in MDD patients than in normal controls (chi(2) = 7.20, p = 0.007; OR = 1.52, 95% CI 1.12-2.06). We also found significantly more carriers of the G allele (GG+AG genotypes) in MDD patients than in normal controls (chi(2) = 10.18, p = 0.001; OR = 2.46, 95% CI 1.40-4.32). Our results support the hypothesis that the -1438A/G polymorphism of the promoter region of the 5-HTR2A gene is associated with MDD patients in a Korean population.
authors.affiliation: Department of Psychiatry, Korea University College of Medicine, Seoul, Korea.
authors.forename: Myoung-Jin
authors.initials: MJ
authors.lastname: Choi
authors.forename: Heon-Jeong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Lee
authors.forename: Byung-Joo
authors.initials: BJ
authors.lastname: Ham
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Cha
authors.forename: Seung-Ho
authors.initials: SH
authors.lastname: Ryu
authors.forename: Min-Soo
authors.initials: MS
authors.lastname: Lee
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004252:DNA Mutational Analysis; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D021122:Protein Subunits / Q000235:genetics; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*
chemical_list: D021122:Protein Subunits; D044402:Receptor, Serotonin, 5-HT2A