Effect of the triterpenoid miliacin on the sensitivity of lymphocytes in the thymus and spleen to dexamethasone-induced apoptosis.
We studied the effect of plant triterpenoid miliacin on dexamethasone-induced apoptosis in thymocytes and splenocytes. Miliacin produced a protective effect on splenocytes by decreasing the degree of DNA fragmentation due to blockade of the cascade cell death distally to the intramembrane phosphatidylserine translocation.
Panfilova
T V
TV
Orenburg State Medical Academy; N. N. Blokhin Russian Research Center for Oncology, Moscow.
Shtil'
A A
AA
Polosukhina
E R
ER
Baryshnikov
A Yu
AY
Frolov
B A
BA
D000818:Animals; D017302:Annexins / Q000378:metabolism; D017209:Apoptosis / Q000187:drug effects*; D002478:Cells, Cultured; D003433:Crosses, Genetic; D003907:Dexamethasone / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D008214:Lymphocytes / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D010946:Plants, Medicinal / Q000737:chemistry / Q000145:classification*; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology; D013997:Time Factors; D014315:Triterpenes / Q000494:pharmacology*
D017302:Annexins; D014315:Triterpenes; C031972:miliacin; D003907:Dexamethasone