Centrosomes: Sfi1p and centrin unravel a structural riddle.
The discovery of Sfi1p as a novel binding partner for the Ca2+-binding protein centrin has provided new insight into the dynamic behavior of centrosomes. Sfi1 binds to multiple centrin molecules along a series of internal repeats, and the complex forms Ca2+-sensitive contractile fibers that function to reorient centrioles and alter centrosome structure.
Salisbury
Jeffrey L
JL
Tumor Biology Program, Mayo Clinic School of Medicine, Rochester, Minnesota 55905, USA. salisbury@mayo.edu
D002118:Calcium / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism; D018385:Centrosome / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D003285:Contractile Proteins / Q000378:metabolism; D056890:Eukaryota / Q000378:metabolism; D020071:Interspersed Repetitive Sequences / Q000235:genetics; D008954:Models, Biological; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000378:metabolism; D015003:Yeasts / Q000378:metabolism*
D002135:Calcium-Binding Proteins; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D003285:Contractile Proteins; D012097:Repressor Proteins; C121820:SFI1 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; C056608:caltractin; D002118:Calcium