Osteoblast and osteoclast activity in a malignant infantile osteopetrosis patient following bone marrow transplantation.
The authors treated a 6-month-old boy with malignant infantile osteopetrosis using bone marrow transplantation. The patient's clinical response was compared with his biochemical response for bone metabolic markers such as tartrate-resistant acid phosphatase 5b (TRAcP 5b) and bone-specific alkaline phosphatase (BAP). Treatment was successful, resulting in a decrease in the serum TRAcP 5b level. These bone-specific markers may be useful for the early assessment of malignant infantile osteopetrosis patients with stem cell transplantation.
Chen
Chun-Jung
CJ
Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Chao
Tsu-Yi
TY
Chu
Der-Ming
DM
Janckila
Anthony J
AJ
Cheng
Shin-Nan
SN
D000135:Acid Phosphatase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016026:Bone Marrow Transplantation; D001859:Bone Neoplasms / Q000628:therapy*; D006085:Graft Survival; D006801:Humans; D007223:Infant; D007527:Isoenzymes / Q000097:blood; D008297:Male; D010006:Osteoblasts / Q000378:metabolism*; D010010:Osteoclasts / Q000378:metabolism*; D010022:Osteopetrosis / Q000628:therapy*; D000071681:Tartrate-Resistant Acid Phosphatase; D016896:Treatment Outcome
D015415:Biomarkers; D007527:Isoenzymes; D000469:Alkaline Phosphatase; C000605510:ACP5 protein, human; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase