title: [Clinical studies on apexification with demineralized dentin matrix].
abstract: OBJECTIVE
  To study the clinical effects of demineralized dentin matrix (DDM) as a apexificating agent.
  
  
  METHODS
  Human teeth were crushed into fragments and were deflated, demineralized, lyophilized to produce DDM. The DDM was used as an apexificating agent to treat 57 teeth compared with calcium hydroxide. X-ray film and clinical observation were undertaken after half a year, one year and two years.
  
  
  RESULTS
  One year later, a barrier in the tooth apex was found in the X-rays film. Then permanent filling material was used. After two years, DDM group had a healing rate of 92.86%, was higher than that of 91.30% in calcium hydroxide group, but there were no statistical significance.
  
  
  CONCLUSIONS
  The findings suggest that DDM can be used as a new apexificating agent. One year after the apexification is the best opportunity to change the apexificating agent to a permanent root canal filling material.
authors.affiliation: Department of Oral Medicine, Stomatological College of Xi'an Jiaotong University, Xi'an 710004, China.
authors.forename: Yuegui
authors.initials: Y
authors.lastname: Jiang
authors.forename: Moyi
authors.initials: M
authors.lastname: Sun
authors.forename: Dong
authors.initials: D
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003764:Dental Materials / Q000627:therapeutic use*; D003790:Dental Pulp Necrosis / Q000628:therapy*; D003804:Dentin; D006801:Humans; D012387:Root Canal Filling Materials / Q000627:therapeutic use; D012390:Root Canal Therapy / Q000379:methods*; D019227:Tooth Apex / Q000187:drug effects*; D014092:Tooth Root / Q000254:growth & development
chemical_list: C093073:Demineralized Dentin Matrix; D003764:Dental Materials; D012387:Root Canal Filling Materials