Predictive value of serial platelet count and VEGF determination for the management of DIC in the Crow-Fukase (POEMS) syndrome.
We report a case of a 62-year-old man diagnosed as Crow-Fukase syndrome (POEMS syndrome), in which the serial platelet count and vascular endothelial growth factor (VEGF) concentration were determined before and during the state of disseminated intravascular coagulation (DIC). The serum VEGF concentration was noted to be gradually decreased prior to DIC, after which it abruptly decreased with a corresponding drop in platelet count upon the onset of DIC. The physiological effects of VEGF are viewed as one of the causative factors in DIC and its abrupt and excessive release may have caused the exacerbation of the patient's clinical symptoms.
Tokashiki
Takashi
T
Third Department of Internal Medicine, Kagoshima University, Kagoshima.
Hashiguchi
Teruto
T
Arimura
Kimiyoshi
K
Eiraku
Nobutaka
N
Maruyama
Ikuro
I
Osame
Mitsuhiro
M
D000991:Antithrombins / Q000627:therapeutic use; D001120:Arginine / Q000031:analogs & derivatives; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000503:physiopathology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000627:therapeutic use; D008875:Middle Aged; D016878:POEMS Syndrome / Q000188:drug therapy / Q000378:metabolism*; D010875:Pipecolic Acids / Q000627:therapeutic use; D010976:Platelet Count; D011237:Predictive Value of Tests; D013449:Sulfonamides; D042461:Vascular Endothelial Growth Factor A / Q000097:blood* / Q000502:physiology
D000991:Antithrombins; D005938:Glucocorticoids; D010875:Pipecolic Acids; D013449:Sulfonamides; D042461:Vascular Endothelial Growth Factor A; D008776:Methylprednisolone Hemisuccinate; D001120:Arginine; C031942:argatroban