Axon guidance: morphogens show the way.
Hedgehog and Wnt family proteins can act as classic developmental morphogens to pattern a field of nai;ve cells. Surprising new studies show that members of these same protein families also act as guidance cues for growing axons in the developing nervous system.
Schnorrer
Frank
F
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr. Bohr-Gasse 7, A-1030, Vienna, Austria. schnorrer@nt.imp.univie.ac.at
Dickson
Barry J
BJ
D000818:Animals; D001369:Axons / Q000378:metabolism*; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D004330:Drosophila / Q000196:embryology*; D029721:Drosophila Proteins / Q000378:metabolism*; D053823:Hedgehog Proteins; D009024:Morphogenesis; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D015534:Trans-Activators / Q000378:metabolism; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D019485:Bone Morphogenetic Proteins; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D051153:Wnt Proteins; D029961:Zebrafish Proteins; C077245:hh protein, Drosophila