[Role of sulfogalactosylglycerolipid and sulfolipidimmobilizing protein 1 in sperm-egg plasma membrane interaction].
Sperm-egg plasma membrane interaction is one of the important steps of mammalian fertilization. Many sperm and egg surface proteins are reported to be involved in sperm-zona pellucida interaction. Sulfogalactosylglycerolipid(SGG) is the major sulfoglycolipid in the germ cells of mammalian and lower vertebrates, mainly in the sperm head. It is a differentiation marker in spermatogenesis restricted to the zygotene and early pachytene spermatocytes. Sulfolipidimmobilizing protein 1 (SLIP1) is the major sulfoglycolipid of mammalian germ cells and eggs, with the same localization as SGG in the sperm. SLIP1 binds specificity to SGG, both playing a vital role in sperm-egg interaction. This article is aimed at reviewing the localization of SGG and SLIP1 in the germ cell surface and their role and related mechanism in gamete formation.
Feng
Xiao-Mei
XM
Center of Medical Laboratory Science, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, Jiangsu 210002, China.
Wang
Jun-Jun
JJ
Huang
Yu-Feng
YF
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology*; D005260:Female; D038983:Galactolipids / Q000502:physiology*; D006801:Humans; D008297:Male; D016601:RNA-Binding Proteins; D013084:Sperm-Ovum Interactions / Q000502:physiology*
D002352:Carrier Proteins; D038983:Galactolipids; C489104:MIF4GD protein, human; D016601:RNA-Binding Proteins; C414346:sulfogalactosylglycerolipid