Lack of a genetic association between the TNXB locus and schizophrenia in a Chinese population.
A recent study demonstrated that the tenascin X (TNXB) gene was associated with schizophrenia in a British population. To replicate the initial finding, we analysed two positive single nucleotide polymorphisms (SNPs), rs1009382 and rs204887 present at the TNXB locus, in a Chinese population by using PCR-based restriction fragment length polymorphism analysis. We recruited a total of 136 family trios consisting of fathers, mothers and affected offspring with schizophrenia. The transmission disequilibrium test did not show allelic association between these two SNPs and schizophrenia, and the rs1009382-rs204887 haplotypes were not associated with the illness either. The present results suggest that the TNXB locus does not appear to be associated with schizophrenia in the Chinese population. Because the TNXB gene is less than 100 kb away from the NOTCH4 locus that was also reported to be associated with schizophrenia, allelic and locus heterogeneity could be possible reasons for the failure to replicate the TNXB finding.
Liu
Lin-Lin
LL
Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun 130021, China.
Wei
Jun
J
Zhang
Xuan
X
Li
Xiu-Yi
XY
Shen
Yan
Y
Liu
Shu-Zheng
SZ
Ju
Gui-Zhi
GZ
Shi
Jie-Ping
JP
Yu
Ya-Qin
YQ
Xu
Qi
Q
Hemmings
Gwynneth P
GP
D002681:China; D002874:Chromosome Mapping; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D018740:Genetic Heterogeneity; D008040:Genetic Linkage / Q000235:genetics; D005820:Genetic Testing; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000235:genetics*; D019063:Tenascin / Q000235:genetics*
D019063:Tenascin; C081865:tenascin X