title: Effect of core body temperature on ventilator-induced lung injury.
abstract: OBJECTIVE
  Ventilator-induced lung injury is a risk in patients requiring elevated ventilatory support pressures. We hypothesized that thermal stress modulates the development of ventilator-induced lung injury.
  
  
  METHODS
  Experimental study.
  
  
  METHODS
  University laboratory.
  
  
  METHODS
  Anesthetized rabbits.
  
  
  METHODS
  Two experimental studies were designed to determine the role of temperature as a cofactor in ventilator-induced lung injury. In the first study, three groups of anesthetized rabbits were randomized to be ventilated for 2 hrs at core body temperatures of 33, 37, or 41 degrees C while ventilated with pressure control ventilation of 15/3 cm H2O (noninjurious settings-control) or 35/3 cm H2O (potentially injurious settings-experimental). To exclude effects arising from cardiac output fluctuations or from extrapulmonary organs, an isolated lung model was used for the second study, perfused at a fixed rate and studied at either 33 degrees C or 41 degrees C.
  
  
  RESULTS
  In the first study, the hyperthermic group compared with the hypothermic animals had significantly reduced mean PaO2 (-114 vs. + 14 mm Hg, p <.05), increased lung edema formation (mean wet weight/dry weight ratio of 8.1 vs. 5.7), and altered pressure-volume curves. The hyperthermic isolated, perfused lungs had an increased ultrafiltration coefficient, formed more edema, and experienced greater alveolar hemorrhage than hypothermic lungs.
  
  
  CONCLUSIONS
  In two studies of ventilator-induced lung injury in rabbits, maintaining hyperthermia compared with hypothermia augmented the development of lung injury. Similar results from both the in vivo and isolated, perfused lung studies suggest that the observed effects were not due to cardiovascular factors or consequences of heating nonpulmonary organs.
authors.affiliation: Department of Traumatology, University of Tokyo, Japan.
authors.forename: So
authors.initials: S
authors.lastname: Suzuki
authors.forename: John R
authors.initials: JR
authors.lastname: Hotchkiss
authors.forename: Toshimichi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Doug
authors.initials: D
authors.lastname: Olson
authors.forename: Alexander B
authors.initials: AB
authors.lastname: Adams
authors.forename: John J
authors.initials: JJ
authors.lastname: Marini
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001831:Body Temperature; D004195:Disease Models, Animal; D005260:Female; D006979:Hyperthermia, Induced; D007035:Hypothermia; D008168:Lung / Q000473:pathology; D055370:Lung Injury; D008297:Male; D011336:Probability; D011654:Pulmonary Edema / Q000209:etiology / Q000503:physiopathology*; D011817:Rabbits; D011897:Random Allocation; D012121:Respiration, Artificial / Q000009:adverse effects*; D012129:Respiratory Function Tests; D015656:Respiratory Mechanics; D018570:Risk Assessment; D012680:Sensitivity and Specificity