Acute topiramate toxicity.
Topiramate (Topamax) is an anti-epileptic medication for which acute toxicity is infrequently reported. A 5-yr-old girl, not previously taking topiramate, developed neurological symptoms after acute ingestion of this medication. She was intermittently agitated, complained of "not being able to feel anything," demonstrated arching movements of the back, and perseverated upon questioning. Computerized tomography of the head and electroencephalography were both normal, and urine toxicology testing for drugs of abuse was negative. A serum topiramate level was 10.5 mcg/mL, confirming the ingestion. The patient was observed for 24 h, over which time her symptoms completely resolved.
Traub
Stephen J
SJ
The Division of Toxicology, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA. straub@bidmc.harvard.edu
Howland
Mary Ann
MA
Hoffman
Robert S
RS
Nelson
Lewis S
LS
D000208:Acute Disease; D000927:Anticonvulsants / Q000097:blood / Q000506:poisoning*; D002675:Child, Preschool; D005260:Female; D005632:Fructose / Q000031:analogs & derivatives* / Q000097:blood / Q000506:poisoning*; D006801:Humans; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D011041:Poisoning / Q000097:blood / Q000150:complications*; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose