Tumour invasion: effects of cell adhesion and motility.
Metastasis is the major cause of failure in cancer therapy. Recent studies of the molecular cell biology of the metastatic process have provided new insights into the mechanisms of cell-cell adhesion, cell-substrate adhesion and cell motility that underly invasion by tumour cells. In this review, Van Roy and Mareel discuss the role of proteins with invasion-promoting and invasion-suppressing functions in metastasis.
Van Roy
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Laboratory of Molecular Biology, University of Ghent, Ledeganckstraat 35, B-9000 Ghent, Belgium.
Mareel
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