title: Relation of cerebral tissue oxygenation index to central venous oxygen saturation in children.
abstract: OBJECTIVE
  To evaluate the relationship between the cerebral tissue oxygenation index measured by near-infrared spectroscopy and central venous oxygen saturation (SvO2) after corrective surgery of congenital heart defects in children.
  
  
  METHODS
  Prospective observational clinical study.
  
  
  METHODS
  A tertiary neonatal and paediatric intensive care unit for paediatric cardiology.
  
  
  METHODS
  Neonates and children consecutively admitted to the paediatric cardiology intensive care unit after corrective surgery of non-cyanotic congenital heart defects.
  
  
  RESULTS
  Forty-three children were studied. Cerebral tissue oxygenation index, measured non-invasively by near-infrared spectroscopy, was compared to SvO2, measured by a catheter placed in the right atrium, and to haemodynamic and respiratory parameters. Pearson's correlation coefficients and p values were calculated. Simultaneously measured values for SvO2 (62.2+/-9.8%, 39.8-80.4%) and cerebral tissue oxygenation index (56.7+/-8.8%, 35.8-71.2%) showed a significant correlation ( r=0.52, p<0.001).
  
  
  CONCLUSIONS
  Cerebral tissue oxygenation index and SvO2 are not interchangeable parameters, but cerebral tissue oxygenation index reflects the haemodynamic influence on cerebral oxygenation after cardiovascular surgery. Further work is necessary to confirm the clinical role of continuous non-invasive measurement of cerebral tissue oxygenation index with regard to the variations of global systemic oxygen consumption after cardiac surgery in children.
authors.affiliation: Department of Intensive Care and Paediatric Cardiology, German Heart Institute Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. nagdyman@dhzb.de
authors.forename: Nicole
authors.initials: N
authors.lastname: Nagdyman
authors.forename: Thilo
authors.initials: T
authors.lastname: Fleck
authors.forename: Sven
authors.initials: S
authors.lastname: Barth
authors.forename: Hashim
authors.initials: H
authors.lastname: Abdul-Khaliq
authors.forename: Brigitte
authors.initials: B
authors.lastname: Stiller
authors.forename: Peter
authors.initials: P
authors.lastname: Ewert
authors.forename: Michael
authors.initials: M
authors.lastname: Huebler
authors.forename: Hermann
authors.initials: H
authors.lastname: Kuppe
authors.forename: Peter E
authors.initials: PE
authors.lastname: Lange
mesh_terms: D000293:Adolescent; D001921:Brain / Q000378:metabolism*; D002405:Catheterization, Central Venous; D002648:Child; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods*; D010092:Oximetry; D010100:Oxygen / Q000378:metabolism*; D011182:Postoperative Care; D011446:Prospective Studies; D012044:Regression Analysis; D019265:Spectroscopy, Near-Infrared
chemical_list: D010100:Oxygen