Biosynthesis of deoxyaminosugars in antibiotic-producing bacteria.
Deoxyaminosugars comprise an important class of deoxysugars synthesized by a variety of different microorganisms; they can be structural components of lipopolysaccharides, extracellular polysaccharides, and secondary metabolites such as antibiotics. Genes involved in the biosynthesis of the deoxyaminosugars are often clustered and are located in the vicinity of other genes required for the synthesis of the final compound. Most of the gene clusters for aminosugar biosynthesis have common features, as they contain genes encoding dehydratases, isomerases, aminotransferases, methyltransferases, and glycosyltransferases. In the present mini-review, the proposed biosynthetic pathways for deoxyaminosugar components of both macrolide and non-macrolide antibiotics are highlighted. The possibilities for genetic manipulations of the deoxyaminosugar biosynthetic pathways aimed at production of novel secondary metabolites are discussed.
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Department of Biotechnology, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
Zotchev
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D000606:Amino Sugars / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001419:Bacteria / Q000235:genetics* / Q000378:metabolism*; D003837:Deoxy Sugars / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D005798:Genes, Bacterial; D016695:Glycosyltransferases / Q000235:genetics / Q000378:metabolism; D006836:Hydro-Lyases / Q000235:genetics / Q000378:metabolism; D007535:Isomerases / Q000235:genetics / Q000502:physiology; D008780:Methyltransferases / Q000235:genetics / Q000378:metabolism; D005810:Multigene Family; D000637:Transaminases / Q000235:genetics / Q000378:metabolism
D000606:Amino Sugars; D000900:Anti-Bacterial Agents; D003837:Deoxy Sugars; D008780:Methyltransferases; D016695:Glycosyltransferases; D000637:Transaminases; D006836:Hydro-Lyases; D007535:Isomerases