Sudden death in growth hormone-treated children with Prader-Willi syndrome.
A 4-year-old boy with Prader-Willi syndrome died suddenly while asleep on day 67 of growth hormone treatment. During treatment, snoring had worsened. Autopsy showed multifocal bronchopneumonia. This case and two others recently published suggest that growth hormone may be associated with obstructive apnea, respiratory infection, and sudden death in this condition.
Van Vliet
Guy
G
Departments of Pediatrics and Pathology, Sainte-Justine Hospital and Research Center, University of Montreal, Quebec, Canada. gvanvliet@justine.umontreal.ca
Deal
Cheri L
CL
Crock
Patricia A
PA
Robitaille
Yves
Y
Oligny
Luc L
LL
D001996:Bronchopneumonia / Q000139:chemically induced*; D002675:Child, Preschool; D000075202:Contraindications; D003645:Death, Sudden / Q000209:etiology*; D017809:Fatal Outcome; D019382:Human Growth Hormone / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011218:Prader-Willi Syndrome / Q000188:drug therapy*
D019382:Human Growth Hormone