[Infection of human papillomavirus in oral benign epithelial proliferation in children].
OBJECTIVE
To investigate the presence of HPV infection of oral mucosa proliferative lesions in children and determine the associations of HPV types with oral mucosa lesions in children.


METHODS
Immunohistochemical method and in situ hybridization techniques were applied to detect human papillomavirus (HPV) infection in biopsies taken from clinical lesions in oral mucosa of 30 children.


RESULTS
The most frequent lesions detected were SCP (66.7%), followed by CA and FEH. The HPV viral antigen was present in 73.3% (22/30) of the oral benign epithelial proliferative lesions in children. A high frequency HPV was found in CA (6/6) and SCP (15/20) by means of IHC. In the ISH positive case, high risk HPV 16/18 was observed in 77.3% (17/22).


CONCLUSIONS
This study demonstrates a high prevalence of HPV infection in children's oral mucosa proliferative lesions, and high-risk HPV16/18 are predominant in children's oral mucosa proliferative lesions.
Liu
Lai-kui
LK
Department of Pathology, West China School of Stomatology, Sichuan University, Chengdu 610041, China.
He
Zhi-xiu
ZX
Li
Yi-ning
YN
Yi
Xin-zhu
XZ
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003218:Condylomata Acuminata / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D017573:Focal Epithelial Hyperplasia / Q000821:virology*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D009061:Mouth Mucosa / Q000821:virology; D010212:Papilloma / Q000821:virology; D027383:Papillomaviridae / Q000302:isolation & purification*
D004279:DNA, Viral