title: Changes in hippocampal SNAP-25 expression following afferent lesions.
abstract: Reductions in SNAP-25 immunohistochemistry were found after removing the glutamatergic and cholinergic inputs to the rat hippocampus. SNAP-25 levels were normalised by 1 month after afferent lesions. Surprisingly, a superimposed cholinergic lesions did not affect the return to normal SNAP-25 levels after a long-term entorhinal cortex lesion. It is concluded that changes in SNAP-25 may represent early markers of synaptic loss following afferent lesions to the hippocampus.
authors.affiliation: Department of Pharmacology, School of Medicine-University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain. mariaja@unav.es
authors.forename: María J
authors.initials: MJ
authors.lastname: Ramírez
authors.forename: William G
authors.initials: WG
authors.lastname: Honer
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Minger
authors.forename: Paul T
authors.initials: PT
authors.lastname: Francis
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002799:Cholinergic Fibers / Q000378:metabolism; D003714:Denervation; D018728:Entorhinal Cortex / Q000378:metabolism / Q000473:pathology*; D015870:Gene Expression; D006624:Hippocampus / Q000378:metabolism*; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009475:Neurons, Afferent / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D050825:Synaptosomal-Associated Protein 25; D013997:Time Factors
chemical_list: D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C494210:Snap25 protein, rat; D050825:Synaptosomal-Associated Protein 25