title: [Abnormalities of molecular biology in premalignant lung lesions].
abstract: In recent twenty years, the incidence of lung cancer has increased quickly in our country. Till now, the morbidity and mortality of lung cancer have occupied the top of the cancers. Early diagnosis is the most important key to increase the five-year survival rate. This review is attempted to summarize the early hereditary events during the development of lung cancer, mainly including the mutation of p53 gene, the abnormal methylation of the promoter area of p16 gene, the loss of heterozygosity of 3p, 8p, 9p, 5q, etc. The purpose is to seek the biological markers during the development of lung cancer to provide theoretical basis for treatment of lung cancer.
authors.affiliation: Cellular and Molecular Biology Key Laboratory of Liaoning Province, Dalian Medical University, Dalian, 116027, P.R.China. shaoshujuan@sohu.com
authors.forename: Shu-Juan
authors.initials: SJ
authors.lastname: Shao
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Pei-Man
authors.initials: PM
authors.lastname: Yang
mesh_terms: D016259:Genes, myc; D016158:Genes, p53; D011905:Genes, ras; D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B / Q000235:genetics; D006801:Humans; D019656:Loss of Heterozygosity; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D011230:Precancerous Conditions / Q000235:genetics* / Q000473:pathology
chemical_list: D034481:Heterogeneous-Nuclear Ribonucleoprotein Group A-B; C439768:hnRNP A2