title: [Comparative study of lipophilicity from immobilized artificial chromatography and n-octanol/buffer systems].
abstract: OBJECTIVE
  To compare lipophilicity measuring scale stemmed from immobilized artificial membrane chromatography and n-octanol/buffer systems.
  
  
  METHODS
  A test set consisted of 27 structurally diverse compounds. The lipophilicity of these were evaluated by both immobilized artificial membrane chromatography (IAMC) and n-octanol/buffer systems, which were expressed as lg kIAM and lg DO/W,7.4, respectively.
  
  
  RESULTS
  With regard to each individual group, good correlation coefficient (r2) over 0.81 was obtained (0.82 for acid; 0.88 for neutral, 0.81 for base and 0.92 for ampholyte, respectively). However, a smaller r2 (0.62) was acquired for all compounds studied than that of each individual group.
  
  
  CONCLUSIONS
  IAMC and n-octanol/buffer systems were shown to be different in lipophilicity.
authors.affiliation: Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. sunjin66@21cn.com
authors.forename: Jin
authors.initials: J
authors.lastname: Sun
authors.forename: Gang
authors.initials: G
authors.lastname: Cheng
authors.forename: Zhong-gui
authors.initials: ZG
authors.lastname: He
authors.forename: Shu-jun
authors.initials: SJ
authors.lastname: Wang
mesh_terms: D002021:Buffers; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D057927:Hydrophobic and Hydrophilic Interactions; D008055:Lipids / Q000737:chemistry*; D008567:Membranes, Artificial; D000442:Octanols / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010743:Phospholipids / Q000737:chemistry
chemical_list: D002021:Buffers; D008055:Lipids; D008567:Membranes, Artificial; D000442:Octanols; D004364:Pharmaceutical Preparations; D010743:Phospholipids