Antigliadin antibodies in Huntington's disease.
The relevance of gluten sensitivity in sporadic and hereditary ataxia pathogenesis is unclear. The authors found high antigliadin antibody titers in 23 of 52 (44%) patients with Huntington's disease (HD), suggesting a previously unrecognized association between HD and gluten sensitivity. The results further question "gluten ataxia" as a distinct disease entity and raise the possibility that antigliadin antibodies in ataxia and other neurodegenerative diseases may be an epiphenomenon, the mechanisms of which remain to be investigated.
Bushara
Khalafalla O
KO
Department of Neurology, University of Minnesota, Minneapolis, USA. busha001@umn.edu
Nance
Martha
M
Gomez
Christopher M
CM
D000906:Antibodies / Q000097:blood*; D005260:Female; D005903:Gliadin / Q000276:immunology*; D006801:Humans; D006816:Huntington Disease / Q000097:blood / Q000235:genetics / Q000276:immunology*; D007070:Immunoglobulin A / Q000097:blood*; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019680:Trinucleotide Repeat Expansion
D000906:Antibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D005903:Gliadin