title: Levofloxacin treatment failure in Haemophilus influenzae pneumonia.
abstract: We describe the first case of failure of oral levofloxacin treatment of community-acquired pneumonia caused by Haemophilus influenzae. The strain showed cross-resistance to fluoroquinolones and carried four mutations in quinolone resistance-determining regions of DNA gyrase and topoisomerase IV genes.
authors.affiliation: Hospital de l'Esperit Sant, Santa Coloma de Gramenet, Barcelona, Spain.
authors.forename: Teresa
authors.initials: T
authors.lastname: Bastida
authors.forename: María
authors.initials: M
authors.lastname: Pérez-Vázquez
authors.forename: José
authors.initials: J
authors.lastname: Campos
authors.forename: María Cristina
authors.initials: MC
authors.lastname: Cortés-Lletget
authors.forename: Federico
authors.initials: F
authors.lastname: Román
authors.forename: Fe
authors.initials: F
authors.lastname: Tubau
authors.forename: Adela G
authors.initials: AG
authors.lastname: de la Campa
authors.forename: Carles
authors.initials: C
authors.lastname: Alonso-Tarrés
mesh_terms: D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D017714:Community-Acquired Infections / Q000188:drug therapy*; D027081:DNA Gyrase / Q000187:drug effects / Q000235:genetics*; D016521:Electrophoresis, Gel, Pulsed-Field; D017809:Fatal Outcome; D005260:Female; D006192:Haemophilus Infections / Q000188:drug therapy*; D006193:Haemophilus influenzae / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D064704:Levofloxacin; D008969:Molecular Sequence Data; D015242:Ofloxacin / Q000627:therapeutic use*; D011014:Pneumonia / Q000188:drug therapy* / Q000382:microbiology; D017211:Treatment Failure
chemical_list: D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin; D027081:DNA Gyrase