Atherosclerosis in dialyzed patients.
In the recent HEMO study, the most common cause of death in dialyzed patients was ischemic heart disease. In Europe there are regional differences, but the mortality due to cardiovascular disease is also very high. The long-lasting controversy whether the high incidence and prevalence of atherosclerotic manifestations (particularly ischemic heart disease) may be explained by known risk factors, or non-traditional risk factors are also involved seems to be partially solved with the increasing evidence that the latter hypothesis is true. Thus, together with classic risk factors such as hypertension, dyslipidemia and diabetes, other situations such as microinflammation, increased concentration of asymmetrical dimethyl-L-arginine, disturbed phosphate metabolism and anemia may represent important risk factors for accelerated atherosclerosis in dialyzed patients.
Ritz
Eberhard
E
University of Heidelberg, Department of Nephrology, Heidelberg, Germany. prof.e.ritz@t-online.de
D000740:Anemia / Q000453:epidemiology; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D001161:Arteriosclerosis / Q000453:epidemiology* / Q000209:etiology; D015415:Biomarkers; D002423:Cause of Death; D015897:Comorbidity; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D003920:Diabetes Mellitus / Q000453:epidemiology; D005060:Europe / Q000453:epidemiology; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D007249:Inflammation / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000628:therapy; D051379:Mice; D018345:Mice, Knockout; D009569:Nitric Oxide / Q000096:biosynthesis; D010710:Phosphates / Q000378:metabolism; D006435:Renal Dialysis / Q000009:adverse effects / Q000706:statistics & numerical data*
D015415:Biomarkers; D010710:Phosphates; D009569:Nitric Oxide; C018524:N,N-dimethylarginine; D001120:Arginine