title: 5-Hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone: a pancreatic lipase inhibitor isolated from Alpinia officinarum.
abstract: A pancreatic lipase inhibitor, 5-hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone (HPH), from the rhizome of Alpinia officinarum (AO) was isolated and its antihyperlipidemic activity was measured. HPH inhibited a pancreatic lipase with an IC(50) value of 1.5 mg/ml (triolein as a substrate). HPH significantly lowered the serum TG level in corn oil feeding-induced triglyceridemic mice, and reduced serum triglyceride (TG) and cholesterol in Triton WR-1339-induced hyperlipidemic mice. However, HPH did not show hypolipidemic activity in high cholesterol diet-induced hyperlipidemic mice. Based on these findings, we propose that PL inhibitors may be effective as hypolipidemic agents.
authors.affiliation: Department of Food Science, Kyung Hee University, 1 Hoegi-Dong, Dongdaemun-Gu, Seoul 130-701, Korea.
authors.forename: Ji-Eun
authors.initials: JE
authors.lastname: Shin
authors.forename: Myung Joo
authors.initials: MJ
authors.lastname: Han
authors.forename: Myoung-Chong
authors.initials: MC
authors.lastname: Song
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
mesh_terms: D032429:Alpinia / Q000737:chemistry*; D000818:Animals; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003314:Corn Oil; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D006536:Heptanes / Q000302:isolation & purification* / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000097:blood / Q000139:chemically induced; D007202:Indicators and Reagents; D008055:Lipids / Q000097:blood*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D020799:Pancrelipase / Q000037:antagonists & inhibitors*; D018517:Plant Roots / Q000737:chemistry; D011092:Polyethylene Glycols; D014280:Triglycerides / Q000097:blood
chemical_list: C488394:5-hydroxy-7-(4'-hydroxy-3'-methoxyphenyl)-1-phenyl-3-heptanone; D008078:Cholesterol, LDL; D004791:Enzyme Inhibitors; D006536:Heptanes; D007202:Indicators and Reagents; D008055:Lipids; D014280:Triglycerides; D011092:Polyethylene Glycols; D020799:Pancrelipase; D003314:Corn Oil; D002784:Cholesterol