Nerve growth factor and wound healing.
The wound healing process following tissue injury consists of a highly regulated sequence of events. Besides many biological activities on both neuronal and nonneuronal cells, nerve growth factor (NGF) has been proposed as an important component of wound healing and tissue repair process in vivo and in vitro. For example, NGF accelerates the rate of wound healing both in normal mice and healing-impaired diabetic mice, and has a potent pharmacological effect in the treatment for ulcer of the skin and cornea in humans. This review summarizes the evidence for the role of NGF in wound healing and tissue repair, and introduces its clinical utility as a therapeutic agent for various diseases.
Kawamoto
Keiko
K
Laboratory of Clinical Immunology, Department of Veterinary Clinic, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Matsuda
Hiroshi
H
D000818:Animals; D001842:Bone and Bones / Q000293:injuries / Q000378:metabolism; D005131:Eye Injuries / Q000209:etiology / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007249:Inflammation / Q000150:complications / Q000378:metabolism; D007794:Lameness, Animal / Q000209:etiology / Q000378:metabolism; D009132:Muscles / Q000293:injuries / Q000378:metabolism; D020932:Nerve Growth Factor / Q000235:genetics / Q000502:physiology*; D010523:Peripheral Nervous System Diseases / Q000378:metabolism; D012867:Skin / Q000293:injuries / Q000378:metabolism; D013997:Time Factors; D014945:Wound Healing / Q000502:physiology*
D020932:Nerve Growth Factor