title: Milbemycin alpha17 and related compounds synthesized from milbemycin A4: synthetic procedure and acaricidal activities.
abstract: Milbemycin alpha17, a 14-demethyl congener of milbemycin A4, has been reported as a natural product. In this paper, we report the successful development of a chemical derivation method to synthesize milbemycin alpha17 from milbemycin A4, as well as our use of a similar method to prepare 24-demethylmilbemycin A4 from the same precursor. The acaricidal activities of these compounds were assessed against the organophosphorus-sensitive two-spotted spider mites (Tetranychus urticae) on the primary leaves of cowpea plants (Vigna sinesis Savi species) by spraying.
authors.affiliation: Agroscience Research Laboratories, Sankyo Agro Co., Ltd. 894 Yasu, Yasu-cho, Yasu-gun, Shiga 520-2342, Japan. tukiya@sankyo-agro.co.jp
authors.forename: Takahiro
authors.initials: T
authors.lastname: Tsukiyama
authors.forename: Ayako
authors.initials: A
authors.lastname: Kinoshita
authors.forename: Reiji
authors.initials: R
authors.lastname: Ichinose
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sato
mesh_terms: D000871:Anthelmintics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D040102:Tetranychidae / Q000187:drug effects*
chemical_list: D000871:Anthelmintics; D018942:Macrolides; C027837:moxidectin