title: Relationship between cerebrospinal fluid and blood dynamics in healthy volunteers and patients with communicating hydrocephalus.
abstract: OBJECTIVE
  Using magnetic resonance imaging (MRI), we investigated cerebral blood and cerebrospinal fluid (CSF) flows in patients with communicating hydrocephalus (CH) and in healthy volunteers to determine the contribution of CSF flow to brain pressure regulation in CH patients.
  
  
  METHODS
  Cine phase-contrast MRI data from 16 healthy volunteers and 12 patients with CH characterized by hyperdynamic aqueductal CSF flow were analyzed using in-house image-processing software that automatically measured flow curves. Amplitude and temporal CSF and blood flow parameters were compared in the 2 groups.
  
  
  RESULTS
  Jugular peak flow occurred significantly earlier (P < 0.01) in the CH patients than in the healthy volunteers. Cervical CSF oscillations were not significantly different between the 2 groups.
  
  
  CONCLUSIONS
  Venous vessel compression and/or changes in intracranial subarachnoid CSF flow produce an increase in ventricular CSF flush that compensates for vascular brain expansion in patients with CH.
authors.affiliation: Department of Imaging and Biophysics, UMR 6600 CNRS, Teaching Hospitals, Jules Verne University of Picardie, Amiens, France. baledent.olivier@chu-amiens.fr
authors.forename: Olivier
authors.initials: O
authors.lastname: Balédent
authors.forename: Catherine
authors.initials: C
authors.lastname: Gondry-Jouet
authors.forename: Marc-Etienne
authors.initials: ME
authors.lastname: Meyer
authors.forename: Giovanni
authors.initials: G
authors.lastname: De Marco
authors.forename: Daniel
authors.initials: D
authors.lastname: Le Gars
authors.forename: Marie-Cécile
authors.initials: MC
authors.lastname: Henry-Feugeas
authors.forename: Ilana
authors.initials: I
authors.lastname: Idy-Peretti
mesh_terms: D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D002555:Cerebrospinal Fluid / Q000502:physiology*; D015170:Cerebrospinal Fluid Pressure; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000503:physiopathology*; D007091:Image Processing, Computer-Assisted; D007427:Intracranial Pressure; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D013997:Time Factors