title: The 870G>A polymorphism of the cyclin D1 gene is not associated with breast cancer.
abstract: A common 870G > A polymorphism in the gene for cyclin D1, CCND1, has been linked to alternative splicing and cancer susceptibility. To analyze its role for breast cancer, we determined the CCND1 genotype in 500 breast cancer patients and 500 controls. CCND1 genotype frequencies were similar among patients and controls. The CCND1 genotype was furthermore not associated with tumor characteristics. We conclude that the CCND1 870G > A polymorphism is not associated with breast cancer.
authors.affiliation: Department of Internal Medicine, Division of Oncology, Karl-Franzens University Graz, Graz, Austria. peter.krippl@klinikum-graz.at
authors.forename: Peter
authors.initials: P
authors.lastname: Krippl
authors.forename: Uwe
authors.initials: U
authors.lastname: Langsenlehner
authors.forename: Wilfried
authors.initials: W
authors.lastname: Renner
authors.forename: Babak
authors.initials: B
authors.lastname: Yazdani-Biuki
authors.forename: Gerald
authors.initials: G
authors.lastname: Wolf
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Wascher
authors.forename: Bernhard
authors.initials: B
authors.lastname: Paulweber
authors.forename: Werner
authors.initials: W
authors.lastname: Weitzer
authors.forename: Andreas
authors.initials: A
authors.lastname: Leithner
authors.forename: Hellmut
authors.initials: H
authors.lastname: Samonigg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D017931:DNA Primers; D005260:Female; D019940:Genes, bcl-1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D017931:DNA Primers