Barrier repair in chronic plaque-type psoriasis.
OBJECTIVE
To investigate barrier repair after mild trauma in lesional skin of psoriasis patients with chronic plaque-type disease and to compare this with non-involved psoriatic skin and normal controls.


METHODS
Transepidermal water loss (TEWL) readings were taken from involved psoriatic skin and non-involved skin of psoriasis patients as well as the skin of normal controls. Three readings were performed at each site: the basal state, immediately after 20 tape strippings and 1 week post stripping.


RESULTS
Higher baseline, post-stripping and 1-week recovery TEWL readings in psoriatic-involved skin compared to non-involved and normal control skin. No significant difference in barrier recovery rate in psoriatic-involved skin compared to non-involved and normal control.


CONCLUSIONS
Although there appears to be a derangement of barrier function in lesional skin of psoriasis patients compared to non-lesional skin and the skin of healthy controls, the barrier recovery function of lesional psoriatic skin is still fully operational.
Goon
Anthony Teik-Jin
AT
National Skin Centre, Singapore, Singapore. anthonygoon@nsc.gov.sg
Yosipovitch
Gil
G
Chan
Yiong-Huak
YH
Goh
Chee-Leok
CL
D001834:Body Water / Q000378:metabolism; D002908:Chronic Disease; D006801:Humans; D010539:Permeability; D011565:Psoriasis / Q000378:metabolism* / Q000473:pathology; D012867:Skin / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D014870:Water Loss, Insensible