Solitary fibrous tumor of the cerebellopontine angle with salivary gland heterotopia: a unique presentation.
We report the unique association of a solitary fibrous tumor of the cerebellopontine angle with ectopic salivary gland tissue in a 53-year-old woman. The patient, diagnosed 21 years earlier with a right cerebellopontine angle fibrous meningioma, presented with a recurrent mass, which, upon surgical removal, showed features of a solitary fibrous tumor. Strong and diffuse immunoreactivity to CD34 and BCL-2 and a negative epithelial membrane antigen immunostain confirmed the diagnosis. Admixed with the spindle cell neoplasm, a bland glandular element composed of small glands and variably dilated tubules was noted. The vague tubuloacinar arrangement of the glands and the presence of acinar cells with a granular, periodic acid-Schiff-positive, basophilic cytoplasm, resembling serous type acini, were features of benign, although ectopic, salivary gland tissue. The presence of a myoepithelial cell layer, surrounding some of the acini and highlighted by the smooth muscle actin immunostain, strengthened this interpretation.
Rodriguez
Fausto
F
Department of Pathology, Mayo Foundation, Rochester, Minnesota 55902, USA.
Scheithauer
Bernd W
BW
Ockner
Daniel M
DM
Giannini
Caterina
C
D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000378:metabolism / Q000473:pathology*; D002530:Cerebellopontine Angle / Q000378:metabolism / Q000473:pathology*; D002828:Choristoma / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008579:Meningioma / Q000473:pathology; D008875:Middle Aged; D018218:Neoplasms, Fibrous Tissue / Q000378:metabolism / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology*; D012469:Salivary Glands; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor