title: Cancer aggregation and complex segregation analysis of families with female non-smoking lung cancer probands in Taiwan.
abstract: Previous studies have found that having a first-degree blood relative with lung cancer was a possible predictor of lung cancer risk, but some studies have indicated that the association is non-significant or only significant for a subset of the studied population. To determine the familial aggregation and whether there is any evidence for a gene controlling the susceptibility to developing lung cancer in female non-smokers, multiple logistic regression methods for estimating covariate effects and maximum likelihood segregation analyses were performed using data from 216 female non-smoking lung cancer probands (2328 individuals) in a population-based case-control study. Having a family history of lung cancer was found to be a significant predictor of lung cancer for non-smoking females (Adjusted Odds Ratio (OR)=5.7, 95% Confidence Interval (CI)=1.9-16.9). Having a female relative with lung cancer (adjusted OR=14.4, 95% CI=2.7-75.5) was more strongly associated with the lung cancer risk than was having a male relative with lung cancer. This association was stronger for probands aged less than 60 years at onset (adjusted OR=11.2, 95% CI=2.2-56.9). All of the Mendelian models fitted the data significantly better than the sporadic (no major type) model or the environmental model (P<0.00l). The Mendelian codominant models provided the best fit of the data for the early onset probands and showed a stronger effect for a major susceptibility locus for non-smoking lung cancer probands. The results of this study provide evidence that a rare autosomal codominant gene may influence the risk lung cancer in non-smoker and is responsible for the familial aggregation observed in non-smoking lung cancer patients.
authors.affiliation: Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Road, Kaohsiung, Taiwan, ROC.
authors.forename: P-F
authors.initials: PF
authors.lastname: Wu
authors.forename: C-H
authors.initials: CH
authors.lastname: Lee
authors.forename: M-J
authors.initials: MJ
authors.lastname: Wang
authors.forename: W B
authors.initials: WB
authors.lastname: Goggins
authors.forename: T-A
authors.initials: TA
authors.lastname: Chiang
authors.forename: M-S
authors.initials: MS
authors.lastname: Huang
authors.forename: Y-C
authors.initials: YC
authors.lastname: Ko
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D010375:Pedigree; D015995:Prevalence; D012044:Regression Analysis; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology