Retention of atherogenic lipoproteins in atherogenesis.
Atherosclerosis is a multifactorial disease whose pathogenesis is still unclear. Mounting evidence, however, supports the concept that subendothelial retention of apoB100-containing lipoproteins is the initiating event in atherogenesis. Subsequently, a series of biological responses to this retained material leads to specific molecular and cellular processes that promote lesion formation.
Gustafsson
M
M
Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska Academy at Göteborg University, 413 45, Göteborg, Sweden.
Flood
C
C
Jirholt
P
P
Borén
J
J
D001055:Apolipoproteins B / Q000235:genetics; D001161:Arteriosclerosis / Q000097:blood* / Q000209:etiology / Q000473:pathology*; D003327:Coronary Disease / Q000097:blood / Q000209:etiology / Q000473:pathology; D006025:Glycosaminoglycans / Q000097:blood; D006801:Humans; D007249:Inflammation; D008074:Lipoproteins / Q000097:blood*; D008954:Models, Biological
D001055:Apolipoproteins B; D006025:Glycosaminoglycans; D008074:Lipoproteins