Is year of radical prostatectomy a predictor of outcome in prostate cancer?
OBJECTIVE
We examined whether the year in which radical prostatectomy (RP) was performed is a predictor of treatment outcome after controlling for standard prognostic factors.


METHODS
We examined the association between RP year and outcome in 6,556 patients from 7 centers using preoperative and pathological features. Patients underwent surgery between 1985 and 2000. The variables analyzed were RP year, clinical stage, pretreatment prostate specific antigen, biopsy Gleason sum, RP Gleason sum, margin status, level of extracapsular extension, seminal vesicle status, lymph node status, neoadjuvant hormones and adjuvant therapy. Median followup was 23 months (maximum 166). Separate Cox multivariate regression analyses were performed to analyze preoperative and postoperative factors.


RESULTS
RP year was a predictor of outcome on preoperative analysis (p = 0.006) but not on postoperative analysis (p = 0.130). Patient outcome steadily improved with surgery through the mid 1990s and then it appeared to level off.


CONCLUSIONS
When controlling for preoperative features, the year in which RP was performed is a predictor of outcome on multivariate analysis. This effect could not be explained by stage migration.
Cagiannos
Ilias
I
Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Karakiewicz
Pierre
P
Graefen
Markus
M
Eastham
James A
JA
Ohori
Makoto
M
Rabbani
Farhang
F
Reuter
Victor
V
Wheeler
Thomas
T
Kupelian
Patrick
P
Klein
Eric
E
Huland
Hartwig
H
Hammerer
Peter G
PG
Erbersdobler
Andreas
A
Schroeder
Fritz
F
Wildhagen
Mark
M
Quinn
David I
DI
Henshall
Susan M
SM
Grygiel
John J
JJ
Sutherland
Robert L
RL
Stricker
Phillip D
PD
Morash
Christopher G
CG
Scardino
Peter T
PT
Kattan
Michael W
MW
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy / Q000592:standards*; D011471:Prostatic Neoplasms / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome