title: Posterior cingulate metabolic changes occur in Parkinson's disease patients without dementia.
abstract: The basis for cognitive deficits in Parkinson's disease (PD) is unknown. Hippocampal atrophy has been shown in Alzheimer's disease (AD) and PD. N-Acetyl aspartate (NAA)/creatine (Cr) ratio in the posterior cingulate gyrus (PCG) is decreased in AD, but unknown in PD. Volumetric magnetic resonance (MR) imaging (at 1.5 T) determined corrected HC volume and MR spectroscopy (MRS) PCG metabolites in 12 non-demented mild to moderately affected PD patients (six male, six female) and ten controls (five male, five female). Age (PD=60.6 years, control=62.2; P=0.62), education (PD=14.1 years, controls=13.8; P=0.89) and global cognition (Mini-Mental State Exam score: PD=28.7, controls=29.6; P=0.14) did not differ. Only recall (CVLT-II, P=0.046) and NAA/Cr (PD=1.53, controls=1.78; P=0.03) were decreased in PD. Memory correlated with NAA/Cr (r=0.65, P=0.02) in PD. In conclusion, cingulate metabolic changes occur in PD.
authors.affiliation: Department of Medicine (Neurology Division), Room E-223, Glenrose Rehabilitation Hospital, 10230-111th Avenue, University of Alberta, Edmonton, AB, Canada T5G 0B7. richard.camicioli@ualberta.ca
authors.forename: R M
authors.initials: RM
authors.lastname: Camicioli
authors.forename: J R
authors.initials: JR
authors.lastname: Korzan
authors.forename: S L
authors.initials: SL
authors.lastname: Foster
authors.forename: N J
authors.initials: NJ
authors.lastname: Fisher
authors.forename: D J
authors.initials: DJ
authors.lastname: Emery
authors.forename: A C
authors.initials: AC
authors.lastname: Bastos
authors.forename: C C
authors.initials: CC
authors.lastname: Hanstock
mesh_terms: D000368:Aged; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D016022:Case-Control Studies; D002794:Choline / Q000378:metabolism; D003071:Cognition / Q000502:physiology; D003401:Creatine / Q000378:metabolism; D005260:Female; D006179:Gyrus Cinguli / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline