title: An experimental study on the vasoconstriction effect of calcium hydroxide using rat mesentery.
abstract: Calcium hyroxide has been used for eliminating persistent intracanal exudation. In order to address the mechanism behind this action, we investigated whether calcium hydroxide solutions cause the constriction of microvessels in the mesenteric microcirculation bed of rats. The exteriorised mesentery from anaesthetised rats was spread in a chamber, and arterioles, venules and capillaries were viewed under a digital microscope. Various concentrations of calcium hydroxide solutions were applied for 10 sec, and the diameter of the microvessels was recorded. In arterioles, calcium hydroxide solutions caused rapid and transient constriction. A statistically significant difference versus original diameter was detected 1 min after the application of 4.0 x 10(-3) mol/l and 1.0 x 10(-2) mol/l solutions (p < 0.05, one-way analysis of variance and Tukey-Kramer test). No statistically significant constriction occurred in capillaries and venules. It was concluded that the arteriolar constriction might be an explanation for the exudation-controlling effect of intracanal calcium hyroxide dressings.
authors.affiliation: Department of Restorative Sciences, Graduate School, Tokyo Medical and Dental University, Japan. i.kikuchi.endo@tmd.ac.jp
authors.forename: Izumi
authors.initials: I
authors.lastname: Kikuchi
authors.forename: Reiko
authors.initials: R
authors.lastname: Wadachi
authors.forename: Takatomo
authors.initials: T
authors.lastname: Yoshioka
authors.forename: Takashi
authors.initials: T
authors.lastname: Okiji
authors.forename: Chihiro
authors.initials: C
authors.lastname: Kobayashi
authors.forename: Hideaki
authors.initials: H
authors.lastname: Suda
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001160:Arterioles / Q000187:drug effects; D002126:Calcium Hydroxide / Q000008:administration & dosage / Q000494:pharmacology*; D002196:Capillaries / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007091:Image Processing, Computer-Assisted; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects*; D008642:Mesenteric Veins / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013152:Splanchnic Circulation / Q000187:drug effects; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology*; D014699:Venules / Q000187:drug effects
chemical_list: D014662:Vasoconstrictor Agents; D002126:Calcium Hydroxide