title: Intermediate filaments and lipoprotein cholesterol.
abstract: The ability of cells to utilize cholesterol derived from lipoprotein is important in plasma membrane biosynthesis, steroidogenesis and the regulation of sterol synthesis. While the endocytosis of lipoprotein-derived cholesterol has been well characterized, the subsequent events that mediate its post-lysosomal intracellular transport are not understood. Recent studies have suggested that vimentin-type intermediate filaments may have a role in cholesterol transport. The mechanism by which vimentin filaments affect this process is not known, but future studies promise to provide new insights into both the post-lysosomal transport of cholesterol and the intracellular functions of intermediate filaments.
authors.affiliation: Department of Pathology, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Denver, CO 80262, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Evans