title: Dramatic response of choroidal metastases from breast cancer to a combination of trastuzumab and vinorelbine.
abstract: We report the case of a 57-year-old woman with unilateral choroidal metastases from HER-2-positive breast cancer. She was given trastuzumab and vinorelbine with complete resolution of her visual defect after one cycle of treatment. This article illustrates that treatment using trastuzumab-containing chemotherapy regimens in HER-2-overexpressing breast cancer patients with choroidal metastases may be an alternative therapeutic strategy to initial orbital irradiation.
authors.affiliation: National Cancer Center, Singapore.
authors.forename: Zee-Wan
authors.initials: ZW
authors.lastname: Wong
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Phillips
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Ellis
mesh_terms: D000792:Angiography; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary; D002830:Choroid Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary; D002921:Cicatrix / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000188:drug therapy / Q000556:secondary; D012607:Scotoma / Q000209:etiology; D000068878:Trastuzumab; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000077235:Vinorelbine
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D014747:Vinblastine; D000068878:Trastuzumab; D000077235:Vinorelbine