title: Papillon-Lefèvre syndrome.
abstract: Papillon- Lefèvre syndrome (PLS) is a rare autosomal recessive disorder of keratinization characterized by palmoplantar hyperkeratosis, periodontopathy and precocious loss of dentition. The exact pathomechanism of these clinical events mainly remains speculative. This paper describes two cases of PLS with classic clinical features and briefly review the relevant literature.
authors.affiliation: Department of Dermatology, Indira Gandhi Medical College, Shimla, India.
authors.forename: Vikram K
authors.initials: VK
authors.lastname: Mahajan
authors.forename: Narbir S
authors.initials: NS
authors.lastname: Thakur
authors.forename: Nand Lal
authors.initials: NL
authors.lastname: Sharma
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis; D000293:Adolescent; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India; D010214:Papillon-Lefevre Disease / Q000175:diagnosis* / Q000235:genetics*; D010808:Physical Examination; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index