Histone, H1.2: another housekeeping protein that kills.
Histone H1.2, a housekeeping protein that binds nucleosomal linkers, has recently been identified as an apoptogenic factor released from the nucleus to the cytosol in response to double strand DNA breaks. In the cytosol, it promotes the activation of proapoptotic Bcl-2 family proteins, mitochondrial cytochrome c release, and ultimately, cell death.
Zong
Wei-Xing
WX
Abramson Cancer Research Institute, University of Pennsylvania, Philadelphia 19104, USA. zong@mail.med.upenn.edu
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D016923:Cell Death; D045304:Cytochromes c / Q000032:analysis; D004249:DNA Damage; D006657:Histones / Q000502:physiology*; D006801:Humans
D006657:Histones; D045304:Cytochromes c