title: Toxicity profile of intensity-modulated radiation therapy for head and neck carcinoma and potential role of amifostine.
abstract: Organ function preservation in patients with head and neck cancer can be achieved by intensity-modulated radiation therapy (IMRT). Much of the work on the physics of IMRT has been done for currently available IMRT systems. However, clinical data remain scarce. Before IMRT is accepted as a standard of care, more comprehensive clinical data on the outcomes of IMRT are needed to substantiate its superiority and advantages over conventional modes of radiotherapy. Concomitant chemoradiation and altered fractionation schemes improve local-regional control, but at the cost of increased toxicity. This article presents a 3-year update of the toxicity profile and therapeutic outcomes of 126 patients with head and neck carcinoma treated with IMRT. An ongoing trial of concomitant chemotherapy and IMRT with subcutaneous amifostine (Ethyol, WR-2721; MedImmune, Inc, Gaithersburg, MD) for organ function preservation is also discussed.
authors.affiliation: Department of Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
authors.forename: K S Clifford
authors.initials: KS
authors.lastname: Chao
authors.forename: Gokhan
authors.initials: G
authors.lastname: Ozyigit
authors.forename: Wade L
authors.initials: WL
authors.lastname: Thorsdad
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004999:Amifostine / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D020266:Radiotherapy, Conformal / Q000009:adverse effects
chemical_list: D011837:Radiation-Protective Agents; D004999:Amifostine