[Effects of L-nitroarginine on the recovery of traumatic facial paralysis].
OBJECTIVE
To study the effects of constitutive nitric oxide synthase inhibitor L-nitroarginine on the recovery of traumatic facial paralysis in rats and the changes of the expression of cNOS and OX42 in the facial nucleus.


METHODS
L-nitroarginine was intraperitoneally injected into rats and the recovery of facial paralysis was observed at different time point. and the changes of cNOS and OX42 positive neurons were studied in facial nucleus.


RESULTS
Treatment of L-nitroarginine could remarkably inhibit the recovery of traumatic facial paralysis. The cNOS immunoactivity was obvious inhibited in facial nucleus, while the OX42 immunoactivity was obvious increased.


CONCLUSIONS
Endogenous nitric oxide may play an important mediator role on the recovery of traumatic facial paralysis.
Wang
Li-jun
LJ
Department of Stomatology, General Hospital, Chinese People's Armed Police Forces, Beijing 100039, China.
Zhou
Shu-xia
SX
Sun
Chang-kai
CK
D000818:Animals; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D030161:Avian Proteins; D051926:Basigin; D001798:Blood Proteins; D005151:Facial Injuries / Q000150:complications*; D005158:Facial Paralysis / Q000188:drug therapy*; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis; D009569:Nitric Oxide / Q000502:physiology; D019001:Nitric Oxide Synthase / Q000032:analysis; D019335:Nitroarginine / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D030161:Avian Proteins; D001798:Blood Proteins; C102624:Bsg protein, Gallus gallus; C079432:Bsg protein, rat; D008562:Membrane Glycoproteins; D051926:Basigin; D019335:Nitroarginine; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase