title: Mycobacterium tuberculosis isolates belonging to katG gyrA group 2 are associated with clustered cases of tuberculosis in Italian patients.
abstract: Fifty-one consecutive isolates of Mycobacterium tuberculosis, collected during a 2-year period in the north-east of Italy, were subjected to IS6110-RFLP analysis to detect the presence of clusters and assigned to one of the three genotypic groups delineated by single nucleotide polymorphisms in the genes katG and gyrA. All the isolates collected from the local population belonged to group 2 or 3, while group 1 isolates were found only in specimens collected from African immigrants. Clustered cases of tuberculosis, which are likely to be related to recently transmitted infection, were found to be significantly associated with katG gyrA group 2. In the local situation, strains belonging to this group may therefore present a higher risk of transmission.
authors.affiliation: Dipartimento di Scienze Biomediche, Università degli Studi di Trieste, Via Fleming 22, 34127 Trieste, Italy 2Modulo di Microbiologia Polmonare, Ospedale di Cattinara, Trieste, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Dolzani
authors.affiliation: Dipartimento di Scienze Biomediche, Università degli Studi di Trieste, Via Fleming 22, 34127 Trieste, Italy 2Modulo di Microbiologia Polmonare, Ospedale di Cattinara, Trieste, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Rosato
authors.affiliation: Dipartimento di Scienze Biomediche, Università degli Studi di Trieste, Via Fleming 22, 34127 Trieste, Italy 2Modulo di Microbiologia Polmonare, Ospedale di Cattinara, Trieste, Italy.
authors.forename: B
authors.initials: B
authors.lastname: Sartori
authors.affiliation: Dipartimento di Scienze Biomediche, Università degli Studi di Trieste, Via Fleming 22, 34127 Trieste, Italy 2Modulo di Microbiologia Polmonare, Ospedale di Cattinara, Trieste, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Banfi
authors.affiliation: Dipartimento di Scienze Biomediche, Università degli Studi di Trieste, Via Fleming 22, 34127 Trieste, Italy 2Modulo di Microbiologia Polmonare, Ospedale di Cattinara, Trieste, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Lagatolla
authors.affiliation: Dipartimento di Scienze Biomediche, Università degli Studi di Trieste, Via Fleming 22, 34127 Trieste, Italy 2Modulo di Microbiologia Polmonare, Ospedale di Cattinara, Trieste, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Predominato
authors.affiliation: Dipartimento di Scienze Biomediche, Università degli Studi di Trieste, Via Fleming 22, 34127 Trieste, Italy 2Modulo di Microbiologia Polmonare, Ospedale di Cattinara, Trieste, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Fabris
authors.affiliation: Dipartimento di Scienze Biomediche, Università degli Studi di Trieste, Via Fleming 22, 34127 Trieste, Italy 2Modulo di Microbiologia Polmonare, Ospedale di Cattinara, Trieste, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Tonin
authors.affiliation: Dipartimento di Scienze Biomediche, Università degli Studi di Trieste, Via Fleming 22, 34127 Trieste, Italy 2Modulo di Microbiologia Polmonare, Ospedale di Cattinara, Trieste, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Gombac
authors.affiliation: Dipartimento di Scienze Biomediche, Università degli Studi di Trieste, Via Fleming 22, 34127 Trieste, Italy 2Modulo di Microbiologia Polmonare, Ospedale di Cattinara, Trieste, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Monti-Bragadin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000494:pharmacology; D001426:Bacterial Proteins; D002374:Catalase; D016000:Cluster Analysis; D027081:DNA Gyrase / Q000235:genetics*; D004251:DNA Transposable Elements; D024881:Drug Resistance, Bacterial; D005838:Genotype; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000235:genetics; D010088:Oxidoreductases / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D014376:Tuberculosis / Q000453:epidemiology* / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents; D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D010088:Oxidoreductases; D002374:Catalase; C480353:katG protein, Mycobacterium tuberculosis; D027081:DNA Gyrase