title: Lack of circulating Candida mannoprotein antigen in patients with focal hepatosplenic candidiasis.
abstract: The significance of Candida mannoprotein serum detection in 15 patients with haematological malignancies and proven (six cases) or probable (nine cases) hepatosplenic candidiasis was retrospectively evaluated. Circulating mannoprotein antigen was detected in three of six and in one of two serum samples from two patients with probable infection. The antigen was not detected in 38 serum samples of 13 (87%) patients. Thus, in contrast to other deep-seated Candida infections, mannoprotein is infrequently detectable during focal hepatosplenic candidiasis and does not appear to be of diagnostic value.
authors.affiliation: Dipartimento di Biotecnologie Cellulari ed Ematologia, University 'La Sapienza', Via Benevento 6, 00161 Rome, Italy 2Dipartimento di Batteriologia e Micologia Medica, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Girmenia
authors.affiliation: Dipartimento di Biotecnologie Cellulari ed Ematologia, University 'La Sapienza', Via Benevento 6, 00161 Rome, Italy 2Dipartimento di Batteriologia e Micologia Medica, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy.
authors.forename: Pietro
authors.initials: P
authors.lastname: Martino
authors.affiliation: Dipartimento di Biotecnologie Cellulari ed Ematologia, University 'La Sapienza', Via Benevento 6, 00161 Rome, Italy 2Dipartimento di Batteriologia e Micologia Medica, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy.
authors.forename: Flavia
authors.initials: F
authors.lastname: De Bernardis
authors.affiliation: Dipartimento di Biotecnologie Cellulari ed Ematologia, University 'La Sapienza', Via Benevento 6, 00161 Rome, Italy 2Dipartimento di Batteriologia e Micologia Medica, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Boccanera
authors.affiliation: Dipartimento di Biotecnologie Cellulari ed Ematologia, University 'La Sapienza', Via Benevento 6, 00161 Rome, Italy 2Dipartimento di Batteriologia e Micologia Medica, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Cassone
mesh_terms: D000293:Adolescent; D000946:Antigens, Fungal / Q000097:blood*; D002175:Candida / Q000276:immunology*; D002177:Candidiasis / Q000175:diagnosis* / Q000382:microbiology; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis* / Q000382:microbiology; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D013158:Splenic Diseases / Q000175:diagnosis* / Q000382:microbiology
chemical_list: D000946:Antigens, Fungal; D008562:Membrane Glycoproteins; C025363:mannoproteins