title: MR perfusion imaging in proliferative angiopathy.
abstract: Seizures, which may be the main expression of cerebral arteriovenous malformations (CAVM) can be difficult to control medically. Our goal was to use perfusion-weighted imaging (PWI) in correlation with clinical data to detect abnormal areas of the cerebrum related to a particular type of CAVM (proliferative angiopathy) and to study the pathophysiology. We use PWI, with a bolus injection of contrast medium, to investigate seven patients with proliferative angiopathy and fits producing language disturbance. Perfusion parameters were calculated using the first-pass moment theory. Five patients had perimalformative and/or contralateral abnormal areas with relative hyperperfusion (cerebral blood volume +20.7+/-16.2%, blood flow 92.5+/-68.8 ml/min/100 g). Areas of hypoperfusion and venous congestion were detected in two patients. One patient who underwent MRI after a severe focal deficit had no significant haemodynamic abnormality.
authors.affiliation: Neuroradiology Department, CHU de Bicêtre, Paris XI University, 78 rue du Gènèral Leclerc, 94270, Le Kremlin Bicêtre, France. denis.ducreux@bct.ap-hop-paris.fr
authors.forename: D
authors.initials: D
authors.lastname: Ducreux
authors.forename: J F
authors.initials: JF
authors.lastname: Meder
authors.forename: D
authors.initials: D
authors.lastname: Fredy
authors.forename: J
authors.initials: J
authors.lastname: Bittoun
authors.forename: P
authors.initials: P
authors.lastname: Lasjaunias
mesh_terms: D000293:Adolescent; D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D002545:Brain Ischemia / Q000175:diagnosis; D002343:Carotid Artery, Internal / Q000002:abnormalities / Q000473:pathology; D002531:Cerebellum / Q000098:blood supply; D002540:Cerebral Cortex / Q000098:blood supply; D003287:Contrast Media / Q000008:administration & dosage; D003680:Deglutition Disorders / Q000209:etiology; D003937:Diagnosis, Differential; D004292:Dominance, Cerebral / Q000502:physiology; D004621:Embolization, Therapeutic; D004827:Epilepsy / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D005583:Fourier Analysis; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D002538:Intracranial Arteriovenous Malformations / Q000175:diagnosis* / Q000628:therapy; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow / Q000502:physiology; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA