Influence of perftoran on structural and metabolic disturbances in the liver during experimental atherosclerosis.
We evaluated whether perftoran can be used for the correction of structural and metabolic changes in the liver during alimentary atherosclerosis. Perftoran in a dose of 0.3 g/kg normalized the contents of phosphatidylserine, phosphatidic acid, and phosphatidylcholine in the plasma membranes of liver cells in rabbits feeding an atherogenic diet for 2 months. Architectonics of hepatic trabeculae returned to normal, the degree of granular and vacuolar degeneration in hepatocytes decreased, and phagocytic activity of macrophages increased. Individual peculiarities of the effect of perftoran on structural and metabolic changes in the liver were revealed.
Leskova
G F
GF
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Michunskaya
A B
AB
Kobozeva
L P
LP
Klimenko
E D
ED
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology*; D002462:Cell Membrane / Q000737:chemistry; D004036:Diet, Atherogenic; D004353:Drug Evaluation, Preclinical; D005466:Fluorocarbons / Q000627:therapeutic use*; D008099:Liver / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D010743:Phospholipids / Q000032:analysis; D011817:Rabbits
D005466:Fluorocarbons; D010743:Phospholipids