Limited effect of highly active antiretroviral therapy among HIV-positive injecting drug users on the population level.
There is evidence that HIV-positive injecting drug users benefit less than other risk groups from highly active antiretroviral therapy that has been available since 1996. In this multicentre European study the impact of the availability of highly active antiretroviral therapy on the progression rates to AIDS and death among injecting drug users with a documented date of HIV seroconversion is studied. After highly active antiretroviral therapy became available the risk of AIDS and death for injecting drug users decreased by 28% and 36%, which is less than has been reported for other risk groups.
van Asten
Liselotte C
LC
Municipal Health Service, Division of Public Health and Environment, Amsterdam, The Netherlands. Lvasten@gggd.amsterdam.nl
Boufassa
Faroudy
F
Schiffer
Veronique
V
Brettle
Raymond P
RP
Robertson
J Roy
JR
Hernández Aguado
Ildefonso
I
McMenamin
Jim
J
Zangerle
Robert
R
Fontanet
Arnaud
A
Coutinho
Roel A
RA
Prins
Maria
M
D000163:Acquired Immunodeficiency Syndrome / Q000401:mortality; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000706:statistics & numerical data; D015331:Cohort Studies; D018450:Disease Progression; D005060:Europe / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006679:HIV Seropositivity / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D012042:Registries; D018570:Risk Assessment; D015819:Substance Abuse, Intravenous / Q000150:complications / Q000821:virology*; D016019:Survival Analysis; D016896:Treatment Outcome