Muscle-derived stem cells.
Researchers have identified 2 types of stem cells in skeletal muscle: satellite cells and multipotent stem cells (MPSCs). The latter category includes different cell populations isolated by various researchers using several techniques. The methods used to isolate these cells appear to influence the stem cell characteristics of the MPSCs. Although MPSCs and satellite cells could represent different stages of maturation of the same progenitor cells, they also could represent distinct populations of stem cells that exist in skeletal muscle. This article summarizes the recent developments in muscle-derived stem cell research.
Cao
Baohong
B
Departments of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA.
Huard
Johnny
J
D000818:Animals; D001808:Blood Vessels / Q000166:cytology; D001854:Bone Marrow Cells / Q000166:cytology; D002454:Cell Differentiation / Q000502:physiology*; D002469:Cell Separation; D051379:Mice; D039902:Multipotent Stem Cells / Q000166:cytology*; D018482:Muscle, Skeletal / Q000166:cytology* / Q000502:physiology; D012038:Regeneration / Q000502:physiology; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology*; D033581:Stem Cell Transplantation