title: Synthesis and activity of pyrimidinylpropenamide antibiotics: the alkyl analogues of sparsomycin.
abstract: Facile syntheses of sparsomycin (3) and its four analogues (4-7) based on diastereoselective oxidation of sulfide, sulfenylation, and coupling of 6-methyluracylacryllic acid with monooxodithioacetal amine, are described. Studies on the biological activity of morphological reversion on src(ts)-NRK cells were also carried out.
authors.affiliation: Biotechnology Research Center, Toyama Prefectural University, Kosugi, Japan. nori@pu-toyama.ac.jp
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Nakajima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Enomoto
authors.forename: Takehiro
authors.initials: T
authors.lastname: Watanabe
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Matsuura
authors.forename: Makoto
authors.initials: M
authors.lastname: Ubukata
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis / Q000494:pharmacology*; D001358:Avian Sarcoma Viruses / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D051379:Mice; D010084:Oxidation-Reduction; D013033:Sparsomycin / Q000138:chemical synthesis / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000903:Antibiotics, Antineoplastic; D013033:Sparsomycin