title: HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication.
abstract: Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) persists despite a vigorous virus-specific host immune response, and causes adult T-cell leukemia and lymphoma in approximately 2% of infected individuals. Here we report that HTLV-1 has evolved a genetic function to restrict its own replication by a novel post-transcriptional mechanism. The HTLV-1-encoded p30(II) is a nuclear-resident protein that binds to, and retains in the nucleus, the doubly spliced mRNA encoding the Tax and Rex proteins. Because Tex and Rex are positive regulators of viral gene expression, their inhibition by p30(II) reduces virion production. p30(II) inhibits virus expression by reducing Tax and Rex protein expression.
authors.affiliation: Animal Models and Retroviral Vaccines Section, National Cancer Institute, National Institutes of Health, 41/D804, Bethesda, Maryland 20892, USA.
authors.forename: Christophe
authors.initials: C
authors.lastname: Nicot
authors.forename: Miroslav
authors.initials: M
authors.lastname: Dundr
authors.forename: Julie M
authors.initials: JM
authors.lastname: Johnson
authors.forename: Jake R
authors.initials: JR
authors.lastname: Fullen
authors.forename: Norma
authors.initials: N
authors.lastname: Alonzo
authors.forename: Risaku
authors.initials: R
authors.lastname: Fukumoto
authors.forename: Gerald L
authors.initials: GL
authors.lastname: Princler
authors.forename: David
authors.initials: D
authors.lastname: Derse
authors.forename: Tom
authors.initials: T
authors.lastname: Misteli
authors.forename: Genoveffa
authors.initials: G
authors.lastname: Franchini
mesh_terms: D002460:Cell Line; D015967:Gene Expression Regulation, Viral; D016370:Gene Products, rex / Q000235:genetics / Q000378:metabolism; D017930:Genes, Reporter; D016355:Genes, pX; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D012191:Retroviridae Proteins / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D014779:Virus Replication / Q000502:physiology*
chemical_list: D016370:Gene Products, rex; D011993:Recombinant Fusion Proteins; D012191:Retroviridae Proteins; C072814:tof protein, Human T-lymphotropic virus 1