title: Multicomponent reactions are accelerated in water.
abstract: Two multicomponent reactions, the Ugi and Passerini reactions, are accelerated by the use of aqueous solutions. The rate enhancements compared to those by organic solvents can approach 300-fold. Reactions performed in water offer another advantage that products are often insoluble, permitting direct isolation by precipitation. The methods were applied to the preparation of three small combinatorial libraries.
authors.affiliation: Department of Chemistry, Levine Science Research Center, Duke University, Durham, North Carolina, 27708, USA. michael.pirrung@duke.edu
authors.forename: Michael C
authors.initials: MC
authors.lastname: Pirrung
authors.forename: Koushik Das
authors.initials: KD
authors.lastname: Sarma
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D007659:Ketones / Q000737:chemistry; D007700:Kinetics; D007769:Lactams / Q000138:chemical synthesis; D012996:Solutions; D014867:Water / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D007659:Ketones; D007769:Lactams; D012996:Solutions; D014867:Water