title: [Detection of serum S100 protein and tissue polypeptide-specific antigen for diagnosis and treatment of breast cancer].
abstract: OBJECTIVE
  To investigate the expressions of serum S100 protein and tissue polypeptide-specific antigen (TPS) in breast cancer and their clinical implications.
  
  
  METHODS
  Using enzyme-linked immunosorbent assay, the levels of serum S100 protein and TPS were determined in 48 breast cancer patients as well as in 92 control subjects.
  
  
  RESULTS
  The median level of serum S100 protein and TPS were 0.024 microg/L and 135 U/L respectively in the 48 breast cancer patients, among whom their positive rates were 14.6% (7/48) and 50% (24/48) respectively; in stage IV patients, their positive rates were 70% (7/10) and 60% (6/10) respectively. The levels of the serum S100 protein and TPS tended to increase as the disease advanced, and serum S100 protein level was significantly higher in patients with distal metastasis than in those with local relapse of the tumor.
  
  
  CONCLUSIONS
  Progressively elevated levels of serum S100 protein and TPS signify the deterioration of breast cancer, and can be used to estimate the stage and state of breast cancer.
authors.affiliation: Department of Oncology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
authors.forename: Rong-cheng
authors.initials: RC
authors.lastname: Luo
authors.forename: Xin-bing
authors.initials: XB
authors.lastname: He
authors.forename: Hong-bing
authors.initials: HB
authors.lastname: Cai
authors.forename: Ai-min
authors.initials: AM
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000097:blood; D010455:Peptides / Q000097:blood*; D009418:S100 Proteins / Q000097:blood*; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D010455:Peptides; D009418:S100 Proteins; C089984:tissue polypeptide specific antigen