Plasma homocysteine concentrations in adolescents with subclinical hypothyroidism.
OBJECTIVE
Hyperhomocysteinemia is a risk factor for premature atherosclerotic vascular disease and venous thrombosis. The aim of the present study was to assess plasma total homocysteine (tHCys) concentrations in adolescent patients with subclinical hypothyroidism.


METHODS
Nineteen patients with subclinical hypothyroidism and 19 healthy children were studied. Fasting plasma concentrations of tHCys and its putative determinants (plasma concentrations of free thyroxine [FT4], folate, vitamin B12 and renal function) were measured.


RESULTS
tHCys concentrations showed no statistical difference between patients and controls (p > 0.05). Moreover, the difference in tHCys and total cholesterol concentrations was not significant between patients with mild TSH elevations (< or = 10 mIU/l) and patients with prominent TSH elevations (> 10 mIU/l). No correlation was found between tHCys concentrations and its putative determinants.


CONCLUSIONS
We concluded that plasma tHCys concentrations were not increased in adolescent patients with subclinical hypothyroidism.
Atabek
M Emre
ME
Department of Pediatrics, Selcuk University, Faculty of Medicine, Konya, Turkey. meatabek@hotmail.com
Pirgon
Ozgur
O
Erkul
Ibrahim
I
D000293:Adolescent / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D005215:Fasting; D005260:Female; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000150:complications / Q000175:diagnosis; D007037:Hypothyroidism / Q000097:blood*; D007518:Isoantibodies / Q000097:blood; D007668:Kidney / Q000502:physiology; D007677:Kidney Function Tests / Q000379:methods; D013967:Thyroiditis, Autoimmune / Q000150:complications / Q000175:diagnosis; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014805:Vitamin B 12 / Q000097:blood
D007518:Isoantibodies; C035678:anti-Thy antibody; D014284:Triiodothyronine; D006710:Homocysteine; D013972:Thyrotropin; D005492:Folic Acid; D002784:Cholesterol; D014805:Vitamin B 12; D013974:Thyroxine