The progression of maternal RSV antibodies in the offspring.
The concentrations of maternal anti-RSV IgG antibodies were followed in 49 healthy newborns over the first six months of life. At birth, 41 mothers (83%) tested positive for anti-RSV IgG and all of their babies carried maternal anti-RSV IgG. Anti-RSV IgG positivity dropped to 73% at 1 month, 6% at 3 months, and 2% at 6 months. Between 3 and 6 months, 8% did acquire RSV infection, half of them as acute bronchiolitis and half as non-specific respiratory infection. All of the patients who acquired clinical RSV disease had an antibody concentration of <20 RU/ml which may be the cut off value for protection.
Hacimustafaoglu
M
M
Uludag University Medical Faculty, Department of Pediatrics and Pediatric Infectious Diseases, Görükle, Bursa, Turkey. mkemal@uludag.edu.tr
Celebi
S
S
Aynaci
E
E
Sinirtas
M
M
Koksal
N
N
Kucukerdogan
A
A
Ercan
I
I
Goral
G
G
Ildirim
I
I
D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired / Q000276:immunology*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood* / Q000276:immunology; D018357:Respiratory Syncytial Virus Infections / Q000097:blood / Q000276:immunology / Q000635:transmission*; D012136:Respiratory Syncytial Viruses / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000914:Antibodies, Viral; C048844:anti-IgG