No T without D3: a critical role for cyclin D3 in normal and malignant precursor T cells.
A definitive knockout reported in this issue of Cancer Cell by Sicinska et al. reveals an unsuspected role for cyclin D3 in normal T cell development and suggests new therapeutic possibilities in precursor T cell leukemia.
Weng
Andrew P
AP
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA. aweng@partners.org
Aster
Jon C
JC
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D002454:Cell Differentiation; D056743:Cyclin D3; D016213:Cyclins / Q000378:metabolism*; D006801:Humans; D015458:Leukemia, T-Cell / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism*
C534696:CCND3 protein, human; D056743:Cyclin D3; D016213:Cyclins