title: Osteoblast and osteoclast activity in a malignant infantile osteopetrosis patient following bone marrow transplantation.
abstract: The authors treated a 6-month-old boy with malignant infantile osteopetrosis using bone marrow transplantation. The patient's clinical response was compared with his biochemical response for bone metabolic markers such as tartrate-resistant acid phosphatase 5b (TRAcP 5b) and bone-specific alkaline phosphatase (BAP). Treatment was successful, resulting in a decrease in the serum TRAcP 5b level. These bone-specific markers may be useful for the early assessment of malignant infantile osteopetrosis patients with stem cell transplantation.
authors.affiliation: Department of Pediatrics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
authors.forename: Chun-Jung
authors.initials: CJ
authors.lastname: Chen
authors.forename: Tsu-Yi
authors.initials: TY
authors.lastname: Chao
authors.forename: Der-Ming
authors.initials: DM
authors.lastname: Chu
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Janckila
authors.forename: Shin-Nan
authors.initials: SN
authors.lastname: Cheng
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D016026:Bone Marrow Transplantation; D001859:Bone Neoplasms / Q000628:therapy*; D006085:Graft Survival; D006801:Humans; D007223:Infant; D007527:Isoenzymes / Q000097:blood; D008297:Male; D010006:Osteoblasts / Q000378:metabolism*; D010010:Osteoclasts / Q000378:metabolism*; D010022:Osteopetrosis / Q000628:therapy*; D000071681:Tartrate-Resistant Acid Phosphatase; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D000469:Alkaline Phosphatase; C000605510:ACP5 protein, human; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase