Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions.
Resistin is an adipocytokine which plays a role in the development of insulin resistance. In this study, we investigated the direct effect of resistin on vascular endothelial cells. Resistin induced the expression of adhesion molecules such as VCAM-1 and ICAM-1, and long pentraxin 3, a marker of inflammation. The induction of VCAM-1 by resistin was inhibited partially by pitavastatin. Moreover, the induction of VCAM-1 and ICAM-1 by resistin was inhibited by adiponectin, an adipocytokine that improves insulin resistance. Taken together, these results suggest that the balance in the concentrations of adipocytokines such as resistin and adiponectin determines the inflammation status of vasculature, and in turn the progress of atherosclerosis.
Kawanami
Daiji
D
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
Maemura
Koji
K
Takeda
Norihiko
N
Harada
Tomohiro
T
Nojiri
Takefumi
T
Imai
Yasushi
Y
Manabe
Ichiro
I
Utsunomiya
Kazunori
K
Nagai
Ryozo
R
D017667:Adipocytes / Q000378:metabolism*; D052242:Adiponectin; D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology; D015152:Blotting, Northern; D015153:Blotting, Western; D002097:C-Reactive Protein / Q000378:metabolism; D002450:Cell Communication; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D042783:Endothelial Cells / Q000378:metabolism*; D017930:Genes, Reporter; D006729:Hormones, Ectopic / Q000502:physiology*; D006801:Humans; D007333:Insulin Resistance; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D011506:Proteins / Q000378:metabolism / Q000502:physiology*; D011804:Quinolines / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D052243:Resistin; D000683:Serum Amyloid P-Component / Q000378:metabolism; D013997:Time Factors; D014162:Transfection; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism; D000099153:Pentraxins
D052242:Adiponectin; D002097:C-Reactive Protein; D016207:Cytokines; D006729:Hormones, Ectopic; D018799:Intercellular Adhesion Molecule-1; D036341:Intercellular Signaling Peptides and Proteins; D016328:NF-kappa B; D011506:Proteins; D011804:Quinolines; D012333:RNA, Messenger; D052243:Resistin; D000683:Serum Amyloid P-Component; D019010:Vascular Cell Adhesion Molecule-1; D000099153:Pentraxins; C499624:RETN protein, human; C499623:Retn protein, mouse; C108475:pitavastatin