Molecular rearrangements within the nuclear pore complexes: a new way to regulate nucleocytoplasmic transport.
Until now, regulation of nucleocytoplasmic transport of macromolecules has been thought to occur mainly through modifications of the cargo molecules. However, in the December 26 issue of Cell, Makhnevych et al. describe a novel mechanism controlling cell cycle progression in yeast that involves subtle molecular rearrangements within the nuclear pore complexes.
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Nuclear Pores and Nucleocytoplasmic Transport, UMR144 CNRS-Institut Curie, 26, rue d'Ulm, 75248 Paris edex 05, France.
D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D002352:Carrier Proteins / Q000378:metabolism; D002453:Cell Cycle / Q000502:physiology*; D028884:Karyopherins / Q000378:metabolism; D022022:Nuclear Pore / Q000378:metabolism*; D015003:Yeasts / Q000235:genetics / Q000378:metabolism*
D002352:Carrier Proteins; D028884:Karyopherins