title: Hypereosinophilic syndrome: case presentation and update.
abstract: Persistent peripheral blood eosinophilia can be associated with a variety of diseases, ranging from parasitic infection to gastrointestinal disease to vasculitis to the hypereosinophilic syndrome (HES). Mucosal ulcerations are a variant presentation of the HES that appear to be markers for a mutation that characterizes a subgroup of patients with HES responsive to treatment with imatinib mesylate. We present a patient with peripheral blood eosinophilia and severe recurrent mucosal ulcers and discuss his presentation in the context of new information about the evaluation, disease progression, and treatment of HES.
authors.affiliation: Department of Dermatology, University of Utah, Salt Lake City, Utah 84132-2409, USA.
authors.forename: Kristin M
authors.initials: KM
authors.lastname: Leiferman
authors.forename: Gerald J
authors.initials: GJ
authors.lastname: Gleich
mesh_terms: D000328:Adult; D001798:Blood Proteins; D003937:Diagnosis, Differential; D004699:Endocardium / Q000473:pathology; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000276:immunology*; D017809:Fatal Outcome; D006331:Heart Diseases / Q000175:diagnosis; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis* / Q000628:therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016898:Interferon-alpha / Q000627:therapeutic use; D007958:Leukocyte Count; D008297:Male; D019226:Oral Ulcer / Q000175:diagnosis* / Q000628:therapy; D010409:Penile Diseases / Q000175:diagnosis* / Q000628:therapy; D012260:Ribonucleases / Q000097:blood; D012883:Skin Ulcer / Q000175:diagnosis; D013156:Splenectomy
chemical_list: D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D007166:Immunosuppressive Agents; D016898:Interferon-alpha; D012260:Ribonucleases