Vaccine-induced CD8+ T cells eliminate tumors by a two-staged attack.
Data presented here demonstrate that vaccine-induced CD8(+) T cells can eliminate their specific tumor-target with a two-staged attack. First, they release interferon-gamma that results in growth arrest of the tumor cells via induction of antiangiogenic mediators. Then, during the latter stages of the immune response, CD8(+) effector T cells eradicate the remaining tumor cells through perforin-mediated lysis. A combination of these two mechanisms is highly effective in the described model, while either pathway alone fails to completely achieve tumor rejection.
Kowalczyk
Dariusz W
DW
Department of Cancer Immunology, Greatpoland Cancer Center, Garbary 15, 61-866 Poznan, Poland.
Wlazlo
Anthony P
AP
Giles-Davis
Wynetta
W
Kammer
Andreas R
AR
Mukhopadhyay
Sunil
S
Ertl
Hildegund C J
HC
D000256:Adenoviridae; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000502:physiology; D019496:Cancer Vaccines / Q000276:immunology* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism* / Q000494:pharmacology; D008175:Lung Neoplasms / Q000628:therapy* / Q000662:veterinary; D008562:Membrane Glycoproteins / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009374:Neoplasms, Experimental; D009389:Neovascularization, Pathologic; D054353:Perforin; D052899:Pore Forming Cytotoxic Proteins
D019496:Cancer Vaccines; D008562:Membrane Glycoproteins; D052899:Pore Forming Cytotoxic Proteins; D054353:Perforin; D007371:Interferon-gamma