Quantitative magnetic resonance imaging in neuropsychiatric systemic lupus erythematosus.
Neuropsychiatric symptoms are common in systemic lupus erythematosus (SLE) but are poorly understood. Although there is a wide spectrum of clinical manifestations, brain histology often simply shows a bland vasculopathy. Magnetic resonance techniques such as magnetic resonance spectroscopy, magnetization transfer imaging and diffusion weighted imaging have been used to try to improve our understanding of the pathophysiological mechanisms involved in neuropsychiatric lupus (NPSLE). This article reviews the current literature on the use of these techniques and their possible future role as diagnostic tools in NPSLE.
Peterson
P L
PL
Lupus Research Unit, St Thomas' Hospital, London, UK. ppeterson@doctors.org.uk
Howe
F A
FA
Clark
C A
CA
Axford
J S
JS
D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D020945:Lupus Vasculitis, Central Nervous System / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D012680:Sensitivity and Specificity