title: Evaluation of interaction between gabapentin and baclofen in the formalin test in mice.
abstract: Gabapentin and baclofen at doses not affecting motor performance, produced dose-dependent inhibition of both phases in the formalin test in mice. Isobolographic analysis revealed an additive interaction between the studied drugs in the second phase of the formalin test. Gabapentin given at doses effective in both phases of the formalin test significantly potentiated baclofen-induced motor impairment.
authors.affiliation: Second Department of Anesthesiology and Intensive Therapy, Medical University, Staszica 16, PL 20-081 Lublin, Poland.
authors.forename: Mirosław
authors.initials: M
authors.lastname: Czuczwar
authors.forename: Jacek
authors.initials: J
authors.lastname: Kiś
authors.forename: Jarogniew
authors.initials: J
authors.lastname: Łuszczki
authors.forename: Waldemar A
authors.initials: WA
authors.lastname: Turski
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Przesmycki
mesh_terms: D000085:Acetates / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000588:Amines; D000818:Animals; D001418:Baclofen / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D003509:Cyclohexanecarboxylic Acids; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D000077206:Gabapentin; D007274:Injections, Intraperitoneal; D051379:Mice; D009069:Movement Disorders / Q000503:physiopathology; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D005680:gamma-Aminobutyric Acid
chemical_list: D000085:Acetates; D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D001418:Baclofen