title: Effect of water extract of Turkish propolis on tuberculosis infection in guinea-pigs.
abstract: Mycobacterium tuberculosis (H(37)R(v))-infected guinea-pig model was used to investigate the effect of water extract of propolis (WEP). After subcutaneous inoculation of tubercle bacilli, each animal received oral WEP (n=9), isoniazid (n=5) or saline (n=6) as placebo and were sacrificed 30 days later. Formation of necrosis was less prominent in the group treated with WEP, but was not statistically significant (P>0.05). The granuloma formation in the same group was more prominent than the placebo and isoniazid groups; however, this finding failed to reach statistical significance by the Kruskal-Wallis test (P>0.05). These findings suggest that Turkish WEP may have a limited effect on the development of tuberculosis infection in this guinea-pig model.
authors.affiliation: Department of Pulmonary Medicine, University of Inonu School of Medicine, Turgut Ozal Medical Centre, Kampus, 44069, Malatya, Turkey. zyildirim@inonu.edu.tr
authors.forename: Zeki
authors.initials: Z
authors.lastname: Yildirim
authors.forename: Süleyman
authors.initials: S
authors.lastname: Hacievliyagil
authors.forename: Nurettin Onur
authors.initials: NO
authors.lastname: Kutlu
authors.forename: Nasuhi Engin
authors.initials: NE
authors.lastname: Aydin
authors.forename: Mine
authors.initials: M
authors.lastname: Kurkcuoglu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Iraz
authors.forename: Riza
authors.initials: R
authors.lastname: Durmaz
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use*; D006168:Guinea Pigs; D008297:Male; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011429:Propolis / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use*; D014376:Tuberculosis / Q000188:drug therapy* / Q000473:pathology; D014421:Turkey
chemical_list: D000995:Antitubercular Agents; D011429:Propolis