The alkaloids and other constituents from the root and stem of Aristolochia elegans.
Two new aristolactams, aristolactam E (1) and aristolactam-AIIIa-6-O-beta-D-glucoside (2), three novel benzoyl benzyltetrahydroisoquinoline ether N-oxide alkaloids, aristoquinoline A (3), aristoquinoline B (4), and aristoquinoline C (5), and a new biphenyl ether, aristogin F (6), together with 62 known compounds have been isolated from the root and stem of Aristolochia elegans Mast. The structures of the new natural products were established on the basis of spectral evidence. Some of the isolated compounds were examined for their antioxidative and antityrosinase activities. Occurrence of the isoquinolones, biphenyl ethers, and benzoyl benzyltetrahydroisoquinoline ether alkaloids in the same plant indicated the definite possibility of these metabolites as biotransformation intermediates of bisbenzyltetrahydroisoquinoline alkaloids. This can be useful to solve the catabolic process of bisbenzyltetrahydroisoquinoline alkaloids.
Shi
Li-Shian
LS
Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan, ROC.
Kuo
Ping-Chung
PC
Tsai
Yao-Lung
YL
Damu
Amooru Gangaiah
AG
Wu
Tian-Shung
TS
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D030022:Aristolochia / Q000737:chemistry* / Q000378:metabolism; D001713:Biphenyl Compounds / Q000737:chemistry; D002942:Circular Dichroism; D004987:Ethers / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry; D007769:Lactams / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D011804:Quinolines / Q000737:chemistry
D000470:Alkaloids; D001713:Biphenyl Compounds; D004987:Ethers; D005960:Glucosides; D007769:Lactams; D010936:Plant Extracts; D011804:Quinolines; C492855:aristolactam E; C492854:aristolactam-AIIIa-6-O-beta-D-glucoside; C492856:aristoquinoline A; C492857:aristoquinoline B; C492858:aristoquinoline C