Prevalence of gestational trophoblastic disease. A single institution experience.
OBJECTIVE
To study the incidence and time trends of gestational trophoblastic disease in the Kingdom of Saudi Arabia (KSA).


METHODS
A retrospective study of medical records of 64,762 pregnancies registered and treated at Security Forces Hospital, Riyadh, KSA, from January 1988 through to December 1998.


RESULTS
Fifty-nine cases of hydatidiform mole (36 complete hydatidiform mole (CHM) and 23 partial hydatidiform mole (PHM) and 2 cases of choriocarcinoma were observed, out of 64,762 pregnancies registered at Security Forces Hospital, Riyadh, KSA, during an 11 year period. The temporal trends exhibited significant reduction in the incidence of GTD during the study period.


CONCLUSIONS
The incidence of GTD has declined with the rapid socio-medical development of the KSA, and is now comparable to that of Europe. The optimal management of this disease depends on prompt diagnosis, correct stratification of the risk category and appropriate treatment using various modalities such as chemotherapy and surgery.
Khashoggi
Tariq Y
TY
Department of Obstetrics and Gynecology, King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia. t_khashoggi@yahoo.co.uk
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017024:Chemotherapy, Adjuvant; D002822:Choriocarcinoma / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D031901:Gestational Trophoblastic Disease / Q000453:epidemiology* / Q000473:pathology* / Q000628:therapy; D006779:Hospitals, Public; D006801:Humans; D006828:Hydatidiform Mole / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D007044:Hysterectomy / Q000379:methods; D008423:Maternal Age; D009367:Neoplasm Staging; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D015995:Prevalence; D012189:Retrospective Studies; D018570:Risk Assessment; D012529:Saudi Arabia / Q000453:epidemiology; D016019:Survival Analysis; D016896:Treatment Outcome