[A pilot study of repair of periodontal bone defects with carbonated phosphate bone cement modified with synthesized peptides in dogs].
OBJECTIVE
To explore the possibility of repairing periodontal defects with carbonated calcium phosphate bone cement (CCPBC) modified with synthesized peptides.


METHODS
Periodontal bone defects in 4 dogs were surgically created and then restored directly with hydroxyapatite (HA), Perioglass, CCPBC and CCPBC modified with peptides. The results were compared at different levels.


RESULTS
Bone replacement materials were lost in HA and Perioglass groups. In the HA group defects were restored with connective tissue. Perioglass group had only a little new bone around materials by alveolar bone. CCPBC could firmly stay in bone defects to maintain the space of bone defects even without membrane use. CCPBC modified with peptides was superior to HA, Perioglass, and CCPBC, surrounded by a great deal of new bone.


CONCLUSIONS
Under limitation of this study, CCPBC modified with peptides has some osteoinuctive activity and may have good prospect for the clinical application in periodontal defect repair.
Ning
Jiang-hai
JH
Department of Stomatology, PLA General Hospital, Beijing 100853, China.
Liu
Hong-chen
HC
Mao
Ke-ya
KY
Pan
He-ping
HP
Wang
Hui-xin
HX
D016301:Alveolar Bone Loss / Q000628:therapy*; D000818:Animals; D001843:Bone Cements; D001861:Bone Regeneration; D018786:Bone Substitutes; D002130:Calcium Phosphates; D004285:Dogs; D017886:Durapatite; D008297:Male
D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; D017886:Durapatite; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous