Prognostic significance of microsatellite instability in curatively resected adenocarcinoma of the small intestine.
Adenocarcinoma of the small intestine (ACSI) is a rare condition with few studies addressing follow-up and prognosis. Tumors of 35 patients with curative resection of an ACSI were retrospectively analyzed by immunohistochemistry: p53, hMLH1, hMSH2 and hMSH6 and microsatellite instability (MSI): BAT-26, BAX, TGF-beta RII. With a median follow up of 6.1 years, the median cancer-specific survival (CSS) was 36.2 months. Patients who were highly instable (MSI-H) (n=10) had a CSS of 49.6 months in contrast to patients with stable tumors (23.2 months) (P=0.010). Additionally, a low tumor stage according to UICC and MSI-H were shown to be independent factors (P=0.005 and P<0.001) for an increased survival in multivariate analysis. Therefore, it is suggested that analysis of the MSI status might prove useful in discerning prognosis within cancers of the same stage.
Brueckl
Wolfgang M
WM
Department of Internal Medicine I, Friedrich-Alexander-University, Ulmenweg 18, Erlangen-Nuremberg, D-91054 Erlangen, Germany. wolfgang.brueckl@med1.imed.uni-erlangen.de
Heinze
Elvira
E
Milsmann
Catrin
C
Wein
Axel
A
Koebnick
Corinna
C
Jung
Andreas
A
Croner
Roland S
RS
Brabletz
Thomas
T
Günther
Klaus
K
Kirchner
Thomas
T
Hahn
Eckhart G
EG
Hohenberger
Werner
W
Becker
Heinz
H
Reingruber
Bertram
B
D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020137:Base Pair Mismatch; D004260:DNA Repair; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007414:Intestinal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D016159:Tumor Suppressor Protein p53