Changes in hippocampal SNAP-25 expression following afferent lesions.
Reductions in SNAP-25 immunohistochemistry were found after removing the glutamatergic and cholinergic inputs to the rat hippocampus. SNAP-25 levels were normalised by 1 month after afferent lesions. Surprisingly, a superimposed cholinergic lesions did not affect the return to normal SNAP-25 levels after a long-term entorhinal cortex lesion. It is concluded that changes in SNAP-25 may represent early markers of synaptic loss following afferent lesions to the hippocampus.
Ramírez
María J
MJ
Department of Pharmacology, School of Medicine-University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain. mariaja@unav.es
Honer
William G
WG
Minger
Stephen L
SL
Francis
Paul T
PT
D000704:Analysis of Variance; D000818:Animals; D002799:Cholinergic Fibers / Q000378:metabolism; D003714:Denervation; D018728:Entorhinal Cortex / Q000378:metabolism / Q000473:pathology*; D015870:Gene Expression; D006624:Hippocampus / Q000378:metabolism*; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009475:Neurons, Afferent / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D050825:Synaptosomal-Associated Protein 25; D013997:Time Factors
D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; C494210:Snap25 protein, rat; D050825:Synaptosomal-Associated Protein 25