title: Serum concentrations of macrophage inhibitory cytokine 1 (MIC 1) as a predictor of miscarriage.
abstract: Macrophage inhibitory cytokine 1 (MIC 1) is thought to have immunomodulatory actions favouring fetal viability. We measured serum concentrations of MIC 1 in asymptomatic women at 6-13 weeks' gestation who subsequently miscarried or who had already miscarried. MIC 1 concentrations in the miscarriage cohort (n=100), were a third of those who had ongoing pregnancies (n=197). Multiples of the median for miscarriage was 0.32 (95% CI 0.23-0.32) versus 1.00 (0.93-1.06) for ongoing pregnancies; p<0.0001. Concentrations were just as low 3 weeks before diagnosis as on the day of diagnosis. That MIC 1 serum concentrations seem to be low weeks before miscarriage suggests possible predictive and causative roles, as well as therapeutic potential.
authors.affiliation: Department of Obstetrics and Gynaecology, Monash University, Monash Medical Centre, Clayton 3168, Victoria, Australia.
authors.forename: Stephen
authors.initials: S
authors.lastname: Tong
authors.forename: Budi
authors.initials: B
authors.lastname: Marjono
authors.forename: David A
authors.initials: DA
authors.lastname: Brown
authors.forename: Sheila
authors.initials: S
authors.lastname: Mulvey
authors.forename: Samuel N
authors.initials: SN
authors.lastname: Breit
authors.forename: Ursula
authors.initials: U
authors.lastname: Manuelpillai
authors.forename: Euan M
authors.initials: EM
authors.lastname: Wallace
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood / Q000175:diagnosis* / Q000517:prevention & control; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood* / Q000502:physiology; D005260:Female; D005328:Fetal Viability / Q000502:physiology; D005865:Gestational Age; D055436:Growth Differentiation Factor 15; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First
chemical_list: D015415:Biomarkers; D016207:Cytokines; C526140:GDF15 protein, human; D055436:Growth Differentiation Factor 15