title: Increasing prevalence of antimicrobial resistance among Enterobacteriaceae uropathogens in Dakar, Senegal: a multicenter study.
abstract: To assess antibiotic susceptibility among Enterobacteriaceae isolated in urine from outpatients in Dakar, Senegal, a prospective multicenter study involving 3 laboratories had been conducted between June and October 2001. During this period, 300 strains were isolated and susceptibility testing was performed against antibiotics commonly used in treatment of community-acquired urinary tract infections (UTI). E. coli and K. pneumoniae represented 89% of isolates. The overall resistance rates of ampicillin, amoxicillin-clavulanic acid, nalidixic acid, fluoroquinolones and cotrimoxazole were respectively 77.3%, 34.7%, 14.7%, 13.3%, and 55%. In the light of these results, a re-evaluation of first line therapies and prudent use of fluoroquinolones is advised. At the same time a continued surveillance of antimicrobial resistance should be developed in Senegal in order to control the emergence of multidrug resistant strains and to establish a national therapeutic guideline for treatment of UTI.
authors.affiliation: Laboratoire de Microbiologie, Institut Pasteur de Dakar, 36 Avenue Pasteur, BP 220, Dakar, Senegal. Dromigny@pasteur.sn
authors.forename: Jacques Albert
authors.initials: JA
authors.lastname: Dromigny
authors.forename: Babacar
authors.initials: B
authors.lastname: Ndoye
authors.forename: Edgard Adam
authors.initials: EA
authors.lastname: Macondo
authors.forename: Pierre
authors.initials: P
authors.lastname: Nabeth
authors.forename: Tidiane
authors.initials: T
authors.lastname: Siby
authors.forename: Jean David
authors.initials: JD
authors.lastname: Perrier-Gros-Claude
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016001:Confidence Intervals; D024901:Drug Resistance, Multiple, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D011336:Probability; D011446:Prospective Studies; D018570:Risk Assessment; D012675:Senegal / Q000453:epidemiology; D014505:Urban Population; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents