title: Increased plasma levels of thioredoxin in patients with coronary spastic angina.
abstract: To determine whether plasma levels of thioredoxin are associated with coronary spasm, we measured the plasma levels of thioredoxin in 170 patients who had <25% organic stenosis in coronary arteriography. According to the results of cardiac catheterization, we divided the patients into two groups: a coronary spastic angina group (n=84) and a chest pain syndrome group (n=86). The plasma levels of thioredoxin were significantly higher in the coronary spastic angina group than in the chest pain syndrome group (40.7 +/- 4.1 versus 18.2 +/- 1.1 ng/ml, p<0.0001). Furthermore, the increased plasma levels of thioredoxin were associated with high disease activity indicated by the frequency of angina attacks (p=0.0004). In multiple logistic regression analysis, the higher levels of thioredoxin [relative risk 14.8, 95% confidence interval (5.13-42.9), p<0.0001] and current smoking [relative risk 3.39, 95% confidence interval (1.31-8.75), p=0.012] were significant and independent variables associated with coronary spasm. We demonstrated that the plasma levels of thioredoxin were increased in the coronary spastic angina group, and increased levels of thioredoxin were associated with high disease activity. The plasma levels of thioredoxin and current smoking were risk factors for coronary spastic angina, and they were independent from other traditional risk factors.
authors.forename: Shinzo
authors.initials: S
authors.lastname: Miyamoto
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kawano
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sakamoto
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Soejima
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kajiwara
authors.forename: Jun
authors.initials: J
authors.lastname: Hokamaki
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Hirai
authors.forename: Seigo
authors.initials: S
authors.lastname: Sugiyama
authors.forename: Michihiro
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yasue
authors.forename: Hajime
authors.initials: H
authors.lastname: Nakamura
authors.forename: Junji
authors.initials: J
authors.lastname: Yodoi
authors.forename: Hisao
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002637:Chest Pain / Q000097:blood*; D003329:Coronary Vasospasm / Q000097:blood* / Q000175:diagnosis*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D013577:Syndrome; D013879:Thioredoxins / Q000097:blood*
chemical_list: D013879:Thioredoxins