title: Effect of iron supplementation on oxidative stress and antioxidant status in iron-deficiency anemia.
abstract: This study was designed to measure the effect of iron supplementation on antioxidant status in iron-deficient anemia, including the time for hemoglobin normalization and at the time of filling of iron body stores. The extent of plasma lipid peroxidation was evaluated by measuring the levels of malondialdehyde and glutathione peroxidase (GSH-Px), and the activities of superoxide dismutase (SOD) and catalase in 63 patients with iron-deficiency anemia before and after 6 wk of iron supplementation and at the time when body iron stores are saturated. After 6 wk of iron supplementation, a significant decrease of oxidative stress was observed in the treated subjects relative to controls (p<0.05). No significant differences existed between treated patients at 6 wk and at the end of the study. The erythrocyte levels of catalase, SOD, and GSH-Px were significantly lower in treated patients relative to controls (p<0.05). These levels increased after 6 wk of supplementation (p<0.05) and showed no significant differences with those at the end of the study.
authors.affiliation: Department of Hematology, Medical School, Selcuk University, Konya, Turkey.
authors.forename: Erdal
authors.initials: E
authors.lastname: Kurtoglu
authors.forename: Aysegul
authors.initials: A
authors.lastname: Ugur
authors.forename: Abdulkerim Kasim
authors.initials: AK
authors.lastname: Baltaci
authors.forename: Levent
authors.initials: L
authors.lastname: Undar
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism*; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D019587:Dietary Supplements; D004912:Erythrocytes / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D007501:Iron / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D008137:Longitudinal Studies; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D007501:Iron; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase