Primary adrenal lymphoma presenting as Addison's disease: case report and review of the literature.
Primary adrenal lymphoma (PAL) is an extremely rare entity and adrenal insufficiency is a common complication. Bilateral enlargement of adrenal glands should raise the suspicion of lymphoma, especially in patients with clinical or laboratory features of adrenal insufficiency. Most of these cases are highly aggressive tumors and should be treated with multiagent chemotherapy. The role of bilateral adrenalectomy and/or radiotherapy cannot be estimated. Our patient with PAL was an 80-year-old man who presented with clinical and laboratory features of adrenal insufficiency. Combination chemotherapy plus rituximab was unsuccessful and our patient died from progressive disease.
Mantzios
George
G
Hematology Department, Metropolitan Hospital, Ethn. Makariou-9 & El. Venizelou-1, Neo-Faliro, 18547 Piraeus, Greece.
Tsirigotis
Panagiotis
P
Veliou
Filio
F
Boutsikakis
Iosif
I
Petraki
Lillian
L
Kolovos
John
J
Papageorgiou
Sotirios
S
Robos
Yannis
Y
D000224:Addison Disease / Q000209:etiology*; D000306:Adrenal Cortex Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001402:B-Lymphocytes / Q000737:chemistry; D002051:Burkitt Lymphoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008942:Mitoxantrone / Q000008:administration & dosage; D009378:Neoplasms, Multiple Primary; D014411:Neoplastic Stem Cells / Q000737:chemistry; D011239:Prednisolone / Q000008:administration & dosage; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D003520:Cyclophosphamide; D011239:Prednisolone; D008942:Mitoxantrone