[Drug treatment of gastro-esophageal reflux disease in pregnant women: consensus guidelines of gastroenterologists and gynaecologists].
Lifestyle changes are recommended as the first step in the treatment of pregnant women with heartburn. If symptoms persist, antacids or the mucoprotective sucralfate can be prescribed. If symptoms are persistent and severe, acid secretion inhibitors may be prescribed; the proton-pump inhibitor omeprazole is the drug of choice. It is unlikely that this drug could harm the fetus but the possibility cannot be entirely excluded. Prescription should be delayed until after the first trimester, whenever possible. Patients who have become pregnant while using these drugs can be reassured.
Weusten
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St. Antonius Ziekenhuis, afd. Maag-, Darm- en Leverziekten, Koekoekslaan 1, 3435 CM Nieuwegein. b.weusten@antonius.net
Exalto
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N
Otten
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MH
D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D005260:Female; D005762:Gastroenterology / Q000592:standards*; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006176:Gynecology / Q000592:standards*; D006801:Humans; D009853:Omeprazole / Q000627:therapeutic use*; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D009853:Omeprazole