title: Synthesis, X-ray crystal structure, antimicrobial activity and photodynamic effects of some thiabendazole complexes.
abstract: An interesting series of metal complexes of thiabendazole (tbz) is synthesized and characterized by elemental analyses and spectroscopic studies. The crystal structure of the hydrogen bonded one dimensional Co(II) complex, namely [Co(tbz)(2)(NO(3))(H(2)O)](NO(3)) is solved by single crystal X-ray diffraction. The complex crystallizes in monoclinic space group P2(1)/a with unit cell parameters, a=14.366(2), b=11.459(4), c=15.942(3) A, beta=113.78(3) degrees and z=4. The unit cell packing reveals an extensive hydrogen bonding involving a water molecule, nitrate ligands and the protonated nitrogen atoms of the tbz ligands, resulting in a one dimensional hydrogen bonding pattern. The antimicrobial activity of the complexes against selected bacteria (Escherichia coli and Bacillus subtilis) and yeast (Aspergillus flavues) is estimated. The relationship between the enzymatic production of ROS and antimicrobial activity of the complexes is examined, and a good correlation between two factors is found. Photodynamic quantum yields of singlet oxygen production (RNO bleaching assay) and rate of superoxide generation (SOD inhibitable ferricytochrome c reduction assay and EPR spin trapping experiments using 5,5-dimethyl-1-pyrroline-N-oxide as spin trap) by the metal complexes have been studied.
authors.affiliation: Department of Chemistry, Saraswathi Narayanan College, Madurai 625 022, Tamil Nadu, India.
authors.forename: K K
authors.initials: KK
authors.lastname: Mothilal
authors.forename: Chandran
authors.initials: C
authors.lastname: Karunakaran
authors.forename: Ayyapan
authors.initials: A
authors.lastname: Rajendran
authors.forename: Ramachandran
authors.initials: R
authors.lastname: Murugesan
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000627:therapeutic use; D018360:Crystallography, X-Ray; D019216:Metals, Heavy / Q000737:chemistry* / Q000378:metabolism; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013481:Superoxides / Q000032:analysis; D013827:Thiabendazole / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D019216:Metals, Heavy; D017319:Photosensitizing Agents; D013481:Superoxides; D013827:Thiabendazole