title: Magnetic resonance evaluation of the interrelationship between articular cartilage and trabecular bone of the osteoarthritic knee.
abstract: OBJECTIVE
  To use high-resolution magnetic resonance imaging (MRI) to determine the relationship between articular cartilage degeneration and trabecular bone changes of the femur, condyles and tibia in human knees with osteoarthritis (OA).
  
  
  METHODS
  Subjects were divided into three groups: without OA (OA0), mild OA (OA1) and severe OA (OA2). Sagittal images of the knee (0.234 x 0.234mm2, 2-mm slice thickness) were obtained at 1.5T and used for calculating the volume and thickness of the femoral and tibial cartilage. Axial images (0.195 x 0.195mm2, 1-mm slice thickness) were used for calculating the trabecular bone structure parameters: apparent bone volume fraction, trabecular number, trabecular separation and trabecular thickness.
  
  
  RESULTS
  Cartilage volume and thickness were less in patients with OA compared to normal controls (P<0.1). Articular cartilage thinning is associated with bone structure loss in the opposite femoral condyle (P<0.05). In varus OA, there were extensive correlations between medial tibia and medial femoral cartilage degeneration, and loss of bone structure in the lateral tibia and lateral condyle. Additional correlations existed between the compartmental differences (lateral minus medial) of cartilage thickness and bone structure.
  
  
  CONCLUSIONS
  Degradation of articular cartilage within a compartment correlates with a loss of bone structure in the opposite compartment. The correlation between the (L-M) differences corroborates this relationship. Malalignment of the knee due to cartilage degeneration is associated with bone formation in the diseased condyle and bone resorption in the opposite compartment.
authors.affiliation: Magnetic Resonance Science Center, University of California, CA, San Francisco, USA. Colleen@mrsc.ucsf.edu
authors.forename: C T
authors.initials: CT
authors.lastname: Lindsey
authors.forename: A
authors.initials: A
authors.lastname: Narasimhan
authors.forename: J M
authors.initials: JM
authors.lastname: Adolfo
authors.forename: Hua
authors.initials: H
authors.lastname: Jin
authors.forename: L S
authors.initials: LS
authors.lastname: Steinbach
authors.forename: T
authors.initials: T
authors.lastname: Link
authors.forename: M
authors.initials: M
authors.lastname: Ries
authors.forename: S
authors.initials: S
authors.lastname: Majumdar
mesh_terms: D000367:Age Factors; D000368:Aged; D002357:Cartilage Diseases / Q000175:diagnosis*; D002358:Cartilage, Articular / Q000473:pathology*; D005260:Female; D005269:Femur / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000175:diagnosis*; D010147:Pain Measurement / Q000379:methods; D013977:Tibia / Q000473:pathology*