Sex determination in fish: Lessons from the sex-determining gene of the teleost medaka, Oryzias latipes.
Although sex determination systems in animals are diverse, sex-determining genes have been identified only in mammals and some invertebrates. Recently, DMY (DM domain gene on the Y chromosome) has been found in the sex-determining region on the Y chromosome of the teleost medaka fish, Oryzias latipes. Functional and expression analyses of DMY show it to be the leading candidate for the male-determining master gene of the medaka. Although some work is required to define DMY as the master sex-determining gene, medaka is expected to be a good experimental animal for investigating the precise mechanisms involved in primary sex determination in non-mammalian vertebrates. In this article, the process of identification of DMY and is summarized and the origins of DMY and sexual development of the medaka's gonads are reviewed. In addition, putative functions of DMY are discussed.
Matsuda
Masaru
M
Precursory Research for Embryonic Science and Technology, Japan Science and Technology Corporation, Laboratory of Reproductive Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan. matsuda@nibb.ac.jp
D000818:Animals; D003001:Cloning, Molecular; D005260:Female; D029941:Fish Proteins / Q000502:physiology*; D008297:Male; D009154:Mutation; D009990:Oryzias / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D019849:Sex Determination Processes; D012733:Sex Differentiation; D014157:Transcription Factors / Q000502:physiology*; D014998:Y Chromosome
C110547:DMRT1 protein; D029941:Fish Proteins; D014157:Transcription Factors