Mycobacterium tuberculosis Beijing genotype and risk for treatment failure and relapse, Vietnam.
Among 2,901 new smear-positive tuberculosis cases in Ho Chi Minh City, Vietnam, 40 cases of treatment failure and 39 relapsing cases were diagnosed. All initial and follow-up Mycobacterium tuberculosis isolates of these case-patients had (nearly) identical restriction fragment length polymorphism patterns, and the Beijing genotype was a significant risk factor for treatment failure and relapse (odds ratio 2.8, 95% confidence interval 1.5 to 5.2).
Lan
Nguyen Thi Ngoc
NT
Pham Ngoc Thach Tuberculosis and Lung Diseases Centre, Ho Chi Minh City, Vietnam.
Lien
Hoang Thi Kim
HT
Tung
Le B
le B
Borgdorff
Martien W
MW
Kremer
Kristin
K
van Soolingen
Dick
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000254:growth & development; D012150:Polymorphism, Restriction Fragment Length; D012008:Recurrence; D013183:Sputum / Q000382:microbiology; D017211:Treatment Failure; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology*; D014744:Vietnam
D000995:Antitubercular Agents; D004269:DNA, Bacterial