The insulin-like growth factor axis in cell cycle progression.
Emerging evidence suggests that members of the Insulin-like Growth Factors (IGFs) family, including IGF-I, IGF-II, the IGF-I receptor (IGF-IR), and the IGF-binding proteins (IGFBPs) play a central role in the development and progression of cancer. Cancer cells exhibit an increased and deregulated proliferative activity. Abnormalities in many positive and negative modulators of the cell cycle are also frequent in many cancer types. Recent advances in the understanding of cell-cycle control mechanisms have been applied to outline the molecular mechanism through which IGFs regulate cell cycle progression. In this review, we will provide a brief overview of the role of the IGF system as a regulator of some components of the cell cycle.
Dupont
J
J
Unité de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, Nouzilly, France. jdupont@tours.inra.fr
Pierre
A
A
Froment
P
P
Moreau
C
C
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002455:Cell Division; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D007335:Insulin-Like Growth Factor II / Q000502:physiology*; D008297:Male; D008954:Models, Biological; D009369:Neoplasms / Q000473:pathology*; D009928:Organ Specificity; D017526:Receptor, IGF Type 1 / Q000502:physiology; D013002:Somatomedins / Q000502:physiology
D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D017526:Receptor, IGF Type 1