[Detection of serum S100 protein and tissue polypeptide-specific antigen for diagnosis and treatment of breast cancer].
OBJECTIVE
To investigate the expressions of serum S100 protein and tissue polypeptide-specific antigen (TPS) in breast cancer and their clinical implications.


METHODS
Using enzyme-linked immunosorbent assay, the levels of serum S100 protein and TPS were determined in 48 breast cancer patients as well as in 92 control subjects.


RESULTS
The median level of serum S100 protein and TPS were 0.024 microg/L and 135 U/L respectively in the 48 breast cancer patients, among whom their positive rates were 14.6% (7/48) and 50% (24/48) respectively; in stage IV patients, their positive rates were 70% (7/10) and 60% (6/10) respectively. The levels of the serum S100 protein and TPS tended to increase as the disease advanced, and serum S100 protein level was significantly higher in patients with distal metastasis than in those with local relapse of the tumor.


CONCLUSIONS
Progressively elevated levels of serum S100 protein and TPS signify the deterioration of breast cancer, and can be used to estimate the stage and state of breast cancer.
Luo
Rong-cheng
RC
Department of Oncology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
He
Xin-bing
XB
Cai
Hong-bing
HB
Li
Ai-min
AM
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000737:chemistry* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000097:blood; D010455:Peptides / Q000097:blood*; D009418:S100 Proteins / Q000097:blood*; D012680:Sensitivity and Specificity
D014408:Biomarkers, Tumor; D010455:Peptides; D009418:S100 Proteins; C089984:tissue polypeptide specific antigen