Clastogenic effect of Carthamus lanatus L. (Asteraceae).
The clastogenic effect of total dichloromethane, methanol and water extracts, four bioactive fractions and three individual constituents from Carthamus lanatus aerial parts were evaluated in mice by bone marrow chromosome aberration assay with mitomycin C as positive control. Significant differences in the percentage of aberrant mitosis of the extracts were observed. The dichloromethane extract exhibited a considerable clastogenic effect and the water extract a negligible one. Different types of chromosome aberrations and time-dependant effects for the active fractions and individual compounds were found.
Topashka-Ancheva
Margarita
M
Institute of Zoology, Bulgarian Academy of Sciences, 1000 Sofia, Bulgaria.
Taskova
Rilka
R
Handjieva
Nedjalka
N
Mikhova
Bozhanka
B
Duddeck
Helmut
H
D000704:Analysis of Variance; D000818:Animals; D031178:Carthamus / Q000737:chemistry* / Q000633:toxicity; D002869:Chromosome Aberrations; D004121:Dimethyl Sulfoxide; D005260:Female; D008297:Male; D000432:Methanol; D008752:Methylene Chloride; D051379:Mice; D008813:Mice, Inbred ICR; D009153:Mutagens / Q000302:isolation & purification / Q000633:toxicity*; D035261:Plant Components, Aerial / Q000737:chemistry / Q000633:toxicity; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity*; D012997:Solvents; D014867:Water
D009153:Mutagens; D010936:Plant Extracts; D012997:Solvents; D014867:Water; D008752:Methylene Chloride; D000432:Methanol; D004121:Dimethyl Sulfoxide