Biphasic effects of ethanol on acetylcholine release in the rat prefrontal cortex.
Low doses of ethanol (0.5 g/kg i.p.) increased, while higher doses (1 g/kg i.p.) reduced acetylcholine (ACh) release in the rat prefrontal cortex (PFC). Ethanol (50-300 mM) applied in the nucleus basalis through a second dialysis probe caused concentration-dependent biphasic changes in prefrontocortical ACh release. Ethanol apparently acts on cholinergic fibers to modulate ACh transmission in the PFC. These results could be of relevance for the bidirectional modulation of working memory by ethanol.
Stancampiano
Roberto
R
Department of Applied Sciences for Biosystems, Division of Human Physiology, Via Porcell 4, I-09124 Cagliari, Italy.
Carta
Manolo
M
Cocco
Stefania
S
Curreli
Rita
R
Rossetti
Zvani Luigi
ZL
Fadda
Fabio
F
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D003956:Dialysis; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D017397:Prefrontal Cortex / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D002492:Central Nervous System Depressants; D000431:Ethanol; D000109:Acetylcholine