title: Severe intoxication after phenytoin infusion: a preventable pharmacogenetic adverse reaction.
authors.forename: David V
authors.initials: DV
authors.lastname: Lardizabal
authors.forename: Hans O
authors.initials: HO
authors.lastname: Lüders
authors.forename: Collin A
authors.initials: CA
authors.lastname: Hovinga
authors.forename: Blaise F D
authors.initials: BF
authors.lastname: Bourgeois
mesh_terms: D000328:Adult; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics / Q000378:metabolism; D015984:Causality; D003198:Computer Simulation; D065729:Cytochrome P-450 CYP2C9; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008508:Medication Errors / Q000009:adverse effects / Q000517:prevention & control; D008962:Models, Theoretical; D010672:Phenytoin / Q000009:adverse effects* / Q000378:metabolism / Q000493:pharmacokinetics*; D011041:Poisoning / Q000209:etiology / Q000235:genetics; D011110:Polymorphism, Genetic
chemical_list: D010672:Phenytoin; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases