title: Utility of [13C] urea breath test for Helicobacter pylori detection in partial gastrectomy patients.
abstract: Many reports on the diagnostic efficacy of the [13C] urea breath test ([13C] UBT) for the detection of Helicobacter pylori in the residual stomach have shown negative results. We previously reported on the utility of [13C] UBT and conducted an evaluation to establish a standardized protocol with a shorter sampling time for [13C] UBT in partial gastrectomy patients. Sixty-two patients who had undergone partial gastrectomy were included. The [13C] UBT protocol included ingestion of 100 mg [13C] urea, use of mouthwash, and the body in a horizontal position on the left side. The sensitivity of [13C] UBT was 95.7%. Thirty minutes and a cutoff of 2.0 per thousand were found to be optimal for the test, with the body position horizontal on the left side. In the present protocol [13C] UBT appears to be a reliable and convenient tool with the same accuracy rate as other routine tests in patients with a remnant stomach.
authors.affiliation: Department of Gastrointestinal Surgery, The University of Tokyo, Tokyo, Japan. kubotak-dis@h.u-tokyo.ac.jp
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kubota
authors.forename: Naoki
authors.initials: N
authors.lastname: Hiki
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Shimizu
authors.forename: Shouji
authors.initials: S
authors.lastname: Shimoyama
authors.forename: Chiaki
authors.initials: C
authors.lastname: Noguchi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tange
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Mafune
authors.forename: Michio
authors.initials: M
authors.lastname: Kaminishi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001944:Breath Tests; D002247:Carbon Isotopes; D005260:Female; D005743:Gastrectomy; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000201:enzymology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014508:Urea; D014510:Urease / Q000032:analysis
chemical_list: D002247:Carbon Isotopes; D014508:Urea; D014510:Urease