title: Prevention of shock wave-induced renal oxidative stress by melatonin: an experimental study.
abstract: Our aim was to evaluate the effects of the potent endogenous free radical scavenger melatonin on extracorporeal-shock-wave lithotripsy (ESWL) induced renal impairment. The study was performed using 30 rabbits which were divided into two groups. Both groups were exposed to 3,000 shock waves at 18 Kv. The animals in the first group were treated with melatonin for 8 days. Controls and melatonin treated rabbits were killed a week after ESWL. MDA, uric acid and white cell counts were used as markers of oxidative stress. The mean levels of uric acid and white cell counts were significantly lower in the melatonin treated group than in the controls. The mean level of MDA was also significantly lower in the melatonin treated group compared to the controls. Our results show that melatonin may exhibit a protective effect on free radical mediated oxidative damage induced by ESWL in rabbit kidney.
authors.affiliation: Department of Urology, School of Medicine, Süleyman Demirel University, Isparta, Turkey. aserel@med.sdu.edu.tr
authors.forename: Tekin Ahmet
authors.initials: TA
authors.lastname: Serel
authors.forename: Fehmi
authors.initials: F
authors.lastname: Ozguner
authors.forename: Sedat
authors.initials: S
authors.lastname: Soyupek
mesh_terms: D000818:Animals; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006470:Hemorrhage / Q000209:etiology; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D007674:Kidney Diseases / Q000209:etiology; D007958:Leukocyte Count; D008096:Lithotripsy / Q000009:adverse effects*; D008315:Malondialdehyde / Q000037:antagonists & inhibitors; D008550:Melatonin / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D011817:Rabbits; D014527:Uric Acid / Q000378:metabolism
chemical_list: D016166:Free Radical Scavengers; D014527:Uric Acid; D008315:Malondialdehyde; D008550:Melatonin