title: No influence of the P-glycoprotein genotype (MDR1 C3435T) on plasma levels of lopinavir and efavirenz during antiretroviral treatment.
abstract: BACKGROUND
  In a retrospective study of HIV patients under antiretroviral therapy, we investigated the influence of the MDR1 genotype (C3435T) on plasma levels of lopinavir (LPV) and efavirenz (EFV).
  
  
  METHODS
  The MDR1 genotype was analysed from 67 patients who were treated with LPV (n = 32; mean treatment period 53 weeks) and/or EFV (n = 43, mean treatment period 105 weeks) between 1999 and 2003. Plasma levels of LPV (trough levels) and EFV (12-h-levels) were determined every three months. Data were analysed by the Kruskal-Wallis test.
  
  
  RESULTS
  There were no significant differences in the LPV and EFV plasma levels with respect to the MDR1 3435 genotype.
  
  
  CONCLUSIONS
  We did not find evidence for an influence of the MDR1 3435 genotype on plasma levels of LPV and EFV.
authors.affiliation: Medical Policlinic, Division of Infectious Diseases, University of Würzburg, Germany. winzer_r@klinik.uni-wuerzburg.de
authors.forename: Ralf
authors.initials: R
authors.lastname: Winzer
authors.forename: P
authors.initials: P
authors.lastname: Langmann
authors.forename: M
authors.initials: M
authors.lastname: Zilly
authors.forename: F
authors.initials: F
authors.lastname: Tollmann
authors.forename: J
authors.initials: J
authors.lastname: Schubert
authors.forename: H
authors.initials: H
authors.lastname: Klinker
authors.forename: B
authors.initials: B
authors.lastname: Weissbrich
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000328:Adult; D000368:Aged; D000480:Alkynes; D019380:Anti-HIV Agents / Q000097:blood* / Q000627:therapeutic use; D048588:Benzoxazines; D003521:Cyclopropanes; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy*; D015497:HIV-1; D006801:Humans; D061466:Lopinavir; D008297:Male; D008875:Middle Aged; D010078:Oxazines / Q000097:blood* / Q000627:therapeutic use; D011110:Polymorphism, Genetic; D011744:Pyrimidinones / Q000097:blood* / Q000627:therapeutic use; D012189:Retrospective Studies
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D010078:Oxazines; D011744:Pyrimidinones; D061466:Lopinavir; C098320:efavirenz