Co-administration of caspofungin and cyclosporine to a kidney transplant patient with pulmonary Aspergillus infection.
A kidney transplant patient on cyclosporine treatment developed focal pneumonia due to Aspergillus fumigatus. The patient was not able to tolerate amphotericin B deoxycholate and was switched to caspofungin. The patient responded favourably without any evidence of toxicity from concomitant use of caspofungin and cylosporine.
Anttila
Veli-Jukka
VJ
Department of Internal Medicine, Division of Infectious Diseases, Helsinki University Central Hospital, Helsinki, Finland. veli-jukka.anttila@hus.fi
Piilonen
Anneli
A
Valtonen
Matti
M
D001228:Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy; D000077336:Caspofungin; D016572:Cyclosporine / Q000008:administration & dosage*; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D054714:Echinocandins; D005500:Follow-Up Studies; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000379:methods; D055666:Lipopeptides; D008172:Lung Diseases, Fungal / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000008:administration & dosage*; D010456:Peptides, Cyclic; D018570:Risk Assessment; D016896:Treatment Outcome
D054714:Echinocandins; D055666:Lipopeptides; D010455:Peptides; D010456:Peptides, Cyclic; D016572:Cyclosporine; D000077336:Caspofungin