title: Spinal analgesics.
abstract: The important issues to be emphasized when considering the intrathecal administration of novel analgesics are their proven antinociceptive effect, safety (short- and long-term effects on the spinal cord and potential toxicities), stability in shelf solution and at body temperature by itself, or in combination with other drugs in spinal fluid, compatibility with a long-term spinal infusion pump, whether they are of sufficiently high potency and solubility to be used in the finite volume of an implanted infusion pump, and if a pharmaceutical company is willing to invest the immense resources needed for US Food and Drug Administration approval and subsequent commercial development.
authors.affiliation: Department of Neurosurgery, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Box 442, Houston, TX 77030, USA.
authors.forename: Hollie
authors.initials: H
authors.lastname: Nguyen
authors.forename: Jason E
authors.initials: JE
authors.lastname: Garber
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Hassenbusch
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007278:Injections, Spinal; D010146:Pain / Q000188:drug therapy*
chemical_list: D000700:Analgesics