title: [Effects of long-term exposure of low-level 2,4-dichlorophenol on the antioxidant defense system in liver of Carassius auratus].
abstract: Under the indoors simulant conditions, the effects of long-term exposure of low-level 2,4-Dichlorophenol on the antioxidant system of larval fishes were studied. The results showed that the activities of catalase (CAT), sedium-dependent glutathione peroxidase (Se-GPx) and the content of oxidized glutathione (GSSG) were induced significantly. The activity of superoxide dismutase (SOD) was induced remarkably when 2,4-Dichlorophenol level was at only 0.005 mg.L-1; the content of reduce glutathione (GSH) was almost suppressed continuously; the activity of glutathione reductase was inhibited firstly and then restored gradually; the activity of glutathione S-transferase (GST) had slight variances among groups. GR, GSH, especially SOD, can act as an early monitoring index of 2,4-Dichlorophenol pollution in aquatic ecosystem.
authors.affiliation: State Key Laboratory of Pollution Control and Resources Reuse, School of Environment, Nanjing University, Nanjing 210093, China. jingfeizhang@sina.com
authors.forename: Jingfei
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaorong
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D002374:Catalase / Q000378:metabolism; D002733:Chlorophenols / Q000633:toxicity*; D005978:Glutathione / Q000032:analysis; D019803:Glutathione Disulfide / Q000032:analysis; D005979:Glutathione Peroxidase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D006054:Goldfish / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000975:Antioxidants; D002733:Chlorophenols; D002374:Catalase; D005979:Glutathione Peroxidase; D005982:Glutathione Transferase; D005978:Glutathione; C004762:2,4-dichlorophenol; D019803:Glutathione Disulfide