title: Escape of malaria parasites from host immunity requires CD4+ CD25+ regulatory T cells.
abstract: Infection with malaria parasites frequently induces total immune suppression, which makes it difficult for the host to maintain long-lasting immunity. Here we show that depletion of CD4(+)CD25(+) regulatory T cells (T(reg)) protects mice from death when infected with a lethal strain of Plasmodium yoelii, and that this protection is associated with an increased T-cell responsiveness against parasite-derived antigens. These results suggest that activation of T(reg) cells contributes to immune suppression during malaria infection, and helps malaria parasites to escape from host immune responses.
authors.affiliation: Department of Immunology & Parasitology, School of Medicine, The University of Tokushima, 3-18-15 Kuramoto, Tokushima, 770-8503, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Hisaeda
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Maekawa
authors.forename: Daiji
authors.initials: D
authors.lastname: Iwakawa
authors.forename: Hiroko
authors.initials: H
authors.lastname: Okada
authors.forename: Kunisuke
authors.initials: K
authors.lastname: Himeno
authors.forename: Kenji
authors.initials: K
authors.lastname: Kishihara
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Tsukumo
authors.forename: Koji
authors.initials: K
authors.lastname: Yasutomo
mesh_terms: D000818:Animals; D015704:CD4 Antigens / Q000276:immunology*; D008288:Malaria / Q000276:immunology* / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D010967:Plasmodium yoelii / Q000276:immunology*; D015375:Receptors, Interleukin-2 / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015704:CD4 Antigens; D015375:Receptors, Interleukin-2