[Determination of platelet activating factor in middle ear effusion of patients with secretory oitits media].
OBJECTIVE
To study the role of platelet activating factor (PAF) in the pathogenesis of secretory otitis media (SOM).


METHODS
The content of PAF in blood plasma and middle ear effusion(MEE) were measured in 56(68years) patients with secretory otitis media and in 40 normal subjects respectively by RP-HPLC.


RESULTS
The concentration of PAF in MEE was remarkably higher than those in blood plasma (P < 0.01). The concentration of PAF in blood plasma in the SOM group was higher than those in the normal control group(P < 0.05). The concentration of PAF of MEE in the mucous fluid group was higher than those in the serous fluid group(P < 0.01).


CONCLUSIONS
PAF might be an important mediator in MEE of SOM, it might be closely related to the persistence of SOM, and might play an important role in the pathogenesis of SOM.
Chen
Liang
L
Department of Otorhinolaryngology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010.
Huang
Yile
Y
You
Jingmin
J
Wang
Jian
J
Chen
Yongting
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D004432:Ear, Middle / Q000378:metabolism*; D005122:Exudates and Transudates / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010034:Otitis Media with Effusion / Q000097:blood* / Q000209:etiology; D010972:Platelet Activating Factor / Q000032:analysis*
D010972:Platelet Activating Factor