Radiotherapy-induced secondary cranial neoplasms in children.
BACKGROUND
Secondary malignant neoplasms (SMN) in CNS tumor survivors has become problem of increasing concern over the last 20 years. These tumors usually occur in a different site from the primary brain tumor several years after treatment.


METHODS
We report secondary cranial malignant neoplasms in three patients who were treated with irradiation and chemotherapy for their primary brain tumors. The first case is a male survivor of an orbital rhabdomyosarcoma who developed a meningioma 8 years later. The other two cases are female survivors of ependymomas who were irradiated at the age of 3 and developed secondary gliomas 8 and 17 years after therapy respectively.


CONCLUSIONS
Patients carry a risk of developing SMNs many years later since irradiation is still an important part of the treatment. An SMN may have a benign course, as in meningioma, or be a dilemma for the patient, as in glioblastoma.
Kantar
Mehmet
M
Department of Pediatrics, Division of Pediatric Oncology, Ege University School of Medicine, 35100, Izmir, Turkey. mkantar@med.ege.edu.tr
Cetingül
Nazan
N
Kansoy
Savaş
S
Anacak
Yavuz
Y
Demirtaş
Eren
E
Erşahin
Yusuf
Y
Mutluer
Saffet
S
D000328:Adult; D000974:Antibodies, Antinuclear / Q000378:metabolism; D000911:Antibodies, Monoclonal / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003893:Desmin / Q000378:metabolism; D004806:Ependymoma / Q000209:etiology; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005909:Glioblastoma / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008579:Meningioma / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects* / Q000379:methods; D018233:Rhabdomyosarcoma, Embryonal / Q000209:etiology* / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism
D000974:Antibodies, Antinuclear; D000911:Antibodies, Monoclonal; D003893:Desmin; D005904:Glial Fibrillary Acidic Protein; D019394:Ki-67 Antigen; C440408:MIB-1 antibody; D009418:S100 Proteins