Indirect potentiometric titration of ascorbic acid in pharmaceutical preparations using copper based mercury film electrode.
A simple and rapid potentiometric method for the estimation of ascorbic acid in pharmaceutical dosage forms has been developed. The method is based on treating ascorbic acid with iodine and titration of the iodide produced equivalent to ascorbic acid with silver nitrate using Copper Based Mercury Film Electrode (CBMFE) as an indicator electrode. Interference study was carried to check possible interference of usual excipients and other vitamins. The precision and accuracy of the method was assessed by the application of lack-of-fit test and other statistical methods. The results of the proposed method and British Pharmacopoeia method were compared using F and t-statistical tests of significance.
Abdul Kamal Nazer
Meeran Mohideen
MM
Department of Chemistry, The New College, Chennai 600-014, India.
Hameed
Abdul Rahman Shahul
AR
Riyazuddin
Patel
P
D001205:Ascorbic Acid / Q000032:analysis*; D002021:Buffers; D003300:Copper / Q000737:chemistry*; D004566:Electrodes; D000431:Ethanol; D005079:Excipients; D007455:Iodine / Q000737:chemistry; D008628:Mercury / Q000737:chemistry*; D009566:Nitrates / Q000737:chemistry; D019999:Pharmaceutical Solutions; D010795:Phthalic Acids; D011199:Potentiometry; D012835:Silver Nitrate / Q000737:chemistry; D012997:Solvents; D013607:Tablets
D002021:Buffers; D005079:Excipients; D009566:Nitrates; D019999:Pharmaceutical Solutions; D010795:Phthalic Acids; D012997:Solvents; D013607:Tablets; D000431:Ethanol; C032279:phthalic acid; D003300:Copper; D012835:Silver Nitrate; D007455:Iodine; D008628:Mercury; D001205:Ascorbic Acid