title: Ability of foot radiographs to predict rheumatoid arthritis in patients with early arthritis.
abstract: OBJECTIVE
  In a cohort of patients with early arthritis, to evaluate how well foot radiographs at study inclusion predicted a diagnosis of rheumatoid arthritis (RA) 2 years later.
  
  
  METHODS
  A cohort of patients with arthritis of less than one year duration was evaluated in a multicenter study and followed for 30 +/- 11 months. An observer blinded to patient data read all 149 hand and foot radiographs done at study inclusion, using item 7 of the 1987 American College of Rheumatology (ACR) criteria for RA and Sharp's method to score erosions and joint space narrowing.
  
  
  RESULTS
  The kappa coefficient for the 1987 ACR item 7 was 0.52 for bony decalcification and 0.87 for erosions. Intra and interobserver correlation coefficients for Sharp's scores ranged from 0.90 to 0.98. Erosions at the feet were significantly associated with RA. The item 7 erosion component at the feet was more specific than the full item 7 (97.5% vs 94%; p = 0.01). Sharp's erosion score at the feet was not better than the erosion component of item 7 (sensitivity 18%; specificity 97.5%). Combined use of radiographs of the hands and feet improved the diagnostic performance of the item 7 erosion component; (sensitivity and specificity of item 7 erosions at the hands combined with the feet were 32.5% and 94.5%, respectively).
  
  
  CONCLUSIONS
  The "erosion" criterion at the feet had the best diagnostic performance and was significantly associated with a diagnosis of RA. Combining hand and foot radiographs improved diagnostic performance.
authors.affiliation: Unit of Rheumatology and the Laboratory of Immunology, Hôpital de la Cavale Blanche, CHU Brest, Brest, France.
authors.forename: Valérie
authors.initials: V
authors.lastname: Devauchelle Pensec
authors.forename: Alain
authors.initials: A
authors.lastname: Saraux
authors.forename: Jean M
authors.initials: JM
authors.lastname: Berthelot
authors.forename: Sabine
authors.initials: S
authors.lastname: Alapetite
authors.forename: Sandrine
authors.initials: S
authors.lastname: Jousse
authors.forename: Gérard
authors.initials: G
authors.lastname: Chales
authors.forename: Jean B
authors.initials: JB
authors.lastname: Thorel
authors.forename: Sylvie
authors.initials: S
authors.lastname: Hoang
authors.forename: Isabelle
authors.initials: I
authors.lastname: Nouy-Trolle
authors.forename: Antoine
authors.initials: A
authors.lastname: Martin
authors.forename: Gilles
authors.initials: G
authors.lastname: Chiocchia
authors.forename: Pierre
authors.initials: P
authors.lastname: Youinou
authors.forename: Paul
authors.initials: P
authors.lastname: Le Goff
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging*; D015331:Cohort Studies; D042241:Early Diagnosis; D005260:Female; D006225:Hand / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008683:Metatarsophalangeal Joint / Q000000981:diagnostic imaging*; D008875:Middle Aged; D010146:Pain / Q000000981:diagnostic imaging; D011237:Predictive Value of Tests; D011859:Radiography; D012680:Sensitivity and Specificity; D013585:Synovitis / Q000000981:diagnostic imaging