Serum lipoprotein(a) concentration and Apo(a) isoform under the condition of renal dysfunction.
A serum lipoprotein(a) (Lp(a)) is an independent risk factor for cardiac events. It is well known that the patients with chronic renal failure (CRF) have a high concentration of serum Lp(a). The purpose of this study was to indicate the relationship between serum Lp(a) concentration and apoprotein(a) (apo(a)) isoforms under the condition of renal dysfunction. One-hundred thirty patients having hypertension, hyperlipidemia, diabetes mellitus and/or CRF were selected in this study. All patients were divided into two groups according to the level of serum creatinine. Serum Lp(a) concentration in the CRF patients (Cr > 2.0 mg/dl) was significantly higher than that in the controls (Cr < 1.2 mg/dl). Many CRF patients had high molecular weight (HMW)-apo(a). This study showed that the increase in HMW-apo(a) was closely accompanied by the increase in serum creatinine levels, and the serum Lp(a) concentration with HMW-apo(a) was higher according to their creatinine levels.
Kuboyama
Miho
M
Department of Internal Medicine, Miyazaki Prefectural Nichinan Hospital, Miyazaki, Japan. miho-k@miyazaki-catv.ne.jp
Ageta
Masato
M
Ishihara
Tabito
T
Fujiura
Yoshitake
Y
Kashio
Nobuyuki
N
Ikushima
Ippei
I
D000368:Aged; D001054:Apolipoproteins A / Q000097:blood* / Q000737:chemistry; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007536:Isomerism; D007676:Kidney Failure, Chronic / Q000097:blood*; D017270:Lipoprotein(a) / Q000097:blood* / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight
D001054:Apolipoproteins A; D017270:Lipoprotein(a); D003404:Creatinine