title: Fibrillary glomerulonephritis associated with essential thrombocytosis.
abstract: A 68-year-old man with a 30-year history of essential thrombocytosis developed nephrotic syndrome. Renal biopsy showed massive deposits of Congo red-negative periodic acid Schiff (PAS)-positive substance in the mesangium and capillary wall that was positive for IgG. Electron microscopic examination revealed 10- to 20-nm fibrils in the deposits, and there was no other organ involvement; thus, we diagnosed fibrillary glomerulonephritis. This is the first report of a case of fibrillary glomerulonephritis associated with essential thrombocytosis.
authors.affiliation: Division of Nephrology and Endocrinology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Asaba
authors.forename: Akihiro
authors.initials: A
authors.lastname: Tojo
authors.forename: Maristela Lika
authors.initials: ML
authors.lastname: Onozato
authors.forename: Natsuko
authors.initials: N
authors.lastname: Mimura
authors.forename: Makiko
authors.initials: M
authors.lastname: Kido
authors.forename: Atsuo
authors.initials: A
authors.lastname: Goto
authors.forename: Hisako
authors.initials: H
authors.lastname: Endo
authors.forename: Toshiro
authors.initials: T
authors.lastname: Fujita
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D005921:Glomerulonephritis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D008854:Microscopy, Electron; D009404:Nephrotic Syndrome / Q000150:complications / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D013922:Thrombocytosis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000893:Anti-Inflammatory Agents; D018906:Antineoplastic Agents, Alkylating; D011239:Prednisolone; D008558:Melphalan