Targeted molecular imaging.
Molecular imaging aims to visualize the cellular and molecular processes occurring in living tissues, and for the imaging of specific molecules in vivo, the development of reporter probes and dedicated imaging equipment is most important. Reporter genes can be used to monitor the delivery and magnitude of therapeutic gene transfer, and the time variation involved. Imaging technologies such as micro-PET, SPECT, MRI and CT, as well as optical imaging systems, are able to non-invasively detect, measure, and report the simultaneous expression of multiple meaningful genes. It is believed that recent advances in reporter probes, imaging technologies and gene transfer strategies will enhance the effectiveness of gene therapy trials.
Kim
E Edmund
EE
Department of Radiology and Medicine, Center for Metabolic Imaging, Nuclear Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ekim@di.mdacc.tmc.edu
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D003287:Contrast Media; D003952:Diagnostic Imaging / Q000379:methods*; D015870:Gene Expression / Q000502:physiology; D017930:Genes, Reporter / Q000502:physiology; D015316:Genetic Therapy; D006801:Humans; D008967:Molecular Biology / Q000379:methods*; D018919:Neovascularization, Physiologic / Q000502:physiology; D051381:Rats
D003287:Contrast Media