title: Limited effect of highly active antiretroviral therapy among HIV-positive injecting drug users on the population level.
abstract: There is evidence that HIV-positive injecting drug users benefit less than other risk groups from highly active antiretroviral therapy that has been available since 1996. In this multicentre European study the impact of the availability of highly active antiretroviral therapy on the progression rates to AIDS and death among injecting drug users with a documented date of HIV seroconversion is studied. After highly active antiretroviral therapy became available the risk of AIDS and death for injecting drug users decreased by 28% and 36%, which is less than has been reported for other risk groups.
authors.affiliation: Municipal Health Service, Division of Public Health and Environment, Amsterdam, The Netherlands. Lvasten@gggd.amsterdam.nl
authors.forename: Liselotte C
authors.initials: LC
authors.lastname: van Asten
authors.forename: Faroudy
authors.initials: F
authors.lastname: Boufassa
authors.forename: Veronique
authors.initials: V
authors.lastname: Schiffer
authors.forename: Raymond P
authors.initials: RP
authors.lastname: Brettle
authors.forename: J Roy
authors.initials: JR
authors.lastname: Robertson
authors.forename: Ildefonso
authors.initials: I
authors.lastname: Hernández Aguado
authors.forename: Jim
authors.initials: J
authors.lastname: McMenamin
authors.forename: Robert
authors.initials: R
authors.lastname: Zangerle
authors.forename: Arnaud
authors.initials: A
authors.lastname: Fontanet
authors.forename: Roel A
authors.initials: RA
authors.lastname: Coutinho
authors.forename: Maria
authors.initials: M
authors.lastname: Prins
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000401:mortality; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000706:statistics & numerical data; D015331:Cohort Studies; D018450:Disease Progression; D005060:Europe / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006679:HIV Seropositivity / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D012042:Registries; D018570:Risk Assessment; D015819:Substance Abuse, Intravenous / Q000150:complications / Q000821:virology*; D016019:Survival Analysis; D016896:Treatment Outcome