Cytotoxic C-benzylated dihydrochalcones from Uvaria acuminata.
Two new C-benzylated dihydrochalcones, isochamuvaritin (1) and acumitin (2), have been isolated from the African medicinal plant Uvaria acuminata, together with the previously reported benzylbenzoate (3), uvaretin (4), isouvaretin (5), diuvaretin (6), and uvangoletin (7). The structural elucidation of compounds 1 and 2 in spectroscopic studies is described. C-Benzylated dihydrochalcones, especially 1, 2, 4, and 6, showed considerable cytotoxicity toward human promyelocytic leukemia HL-60 cells.
Ichimaru
Momoyo
M
Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan. ichimaru@kobepharma-u.ac.jp
Nakatani
Noriyoshi
N
Takahashi
Tomoko
T
Nishiyama
Yumi
Y
Moriyasu
Masataka
M
Kato
Atsushi
A
Mathenge
Simon G
SG
Juma
Francis D
FD
Nganga
Joseph N
JN
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002599:Chalcone / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts; D018517:Plant Roots / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D031046:Uvaria / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D002599:Chalcone