title: CD24 expression is a significant predictor of PSA relapse and poor prognosis in low grade or organ confined prostate cancer.
abstract: BACKGROUND
  The prognostic impact of tumor grading and staging is markedly reduced in organ confined or moderately differentiated prostate cancer, which underscores the importance of new prognostic markers. Evaluating public expression data of prostate cancer, we found an upregulation of the candidate gene CD24.
  
  
  METHODS
  We examined immunohistochemically the expression of CD24 protein in 31 nodal metastases and 102 adenocarcinomas of the prostate and correlated our findings to clinicopathological parameters.
  
  
  RESULTS
  CD24 expression was found in 48% of primary prostate cancer cases and in 68% of lymph node metastases. Kaplan Meier curves and Cox regression analysis showed that CD24 expression was strongly linked to significantly earlier disease progression (relative risk = 3.2), which was especially pronounced in organ confined, or moderately differentiated primary prostate tumors.
  
  
  CONCLUSIONS
  We conclude that CD24 is an important prognostic tissue marker for prostate cancer which could help to define patients of low or high risk of recurrence.
authors.affiliation: Institute of Pathology, Charité University Hospital, Berlin, Germany. glen.kristiansen@charite.de
authors.forename: Glen
authors.initials: G
authors.lastname: Kristiansen
authors.forename: Christian
authors.initials: C
authors.lastname: Pilarsky
authors.forename: Janja
authors.initials: J
authors.lastname: Pervan
authors.forename: Burkhard
authors.initials: B
authors.lastname: Stürzebecher
authors.forename: Carsten
authors.initials: C
authors.lastname: Stephan
authors.forename: Klaus
authors.initials: K
authors.lastname: Jung
authors.forename: Stefan
authors.initials: S
authors.lastname: Loening
authors.forename: Andre
authors.initials: A
authors.lastname: Rosenthal
authors.forename: Manfred
authors.initials: M
authors.lastname: Dietel
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D051927:CD24 Antigen; D018450:Disease Progression; D018572:Disease-Free Survival; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008562:Membrane Glycoproteins; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods*; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000473:pathology*; D012333:RNA, Messenger / Q000096:biosynthesis; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D015854:Up-Regulation
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; D051927:CD24 Antigen; C497889:CD24 protein, human; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D017430:Prostate-Specific Antigen