Development of ERG responses: the ISCEV rod, maximal and cone responses in normal subjects.
OBJECTIVE
Summarize ISCEV ERG responses from normal infants and children.


METHODS
The amplitudes and implicit times of the ISCEV rod, maximal dark-adapted and cone responses from a total of 409 normal infants (n = 128), children and adult controls were compiled. The subjects, aged 1 week to 52 years, were divided into seven age groups, including four in infancy (< 52 weeks). The response parameters for each age group were summarized as percentiles.


RESULTS
In each ISCEV condition, the youngest infants (1-5 weeks) had significantly smaller amplitudes and longer implicit times than adults. Amplitude increased and implicit time decreased systematically with age.


CONCLUSIONS
The developmental changes in ERG responses are significant. The medians and ranges herein provide provisional norms against which the ERG responses from pediatric patients can be compared.
Fulton
Anne B
AB
Department of Ophthalmology, The Children's Hospital, Boston, MA 02115, USA. Anne.Fulton@tch.harvard.edu
Hansen
Ronald M
RM
Westall
Carol A
CA
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D003623:Dark Adaptation; D004596:Electroretinography; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D020419:Photoreceptor Cells, Vertebrate / Q000502:physiology*; D012016:Reference Values