MAP kinase regulation--the oncogene connection.
The mitogen-activated protein kinase (MAP kinase) family of cytoplasmic serine/threonine protein kinases is activated by a wide range of extracellular stimuli. In this review we focus on the accumulating evidence that proteins encoded by proto-oncogenes and oncogenes are either involved in the regulation of the MAP kinase pathway or are its targets.
Leevers
S J
SJ
Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, UK SW3 6JB.
Marshall
C J
CJ