Relation of thrombomodulin gene polymorphisms to acute myocardial infarction in patients <or =50 years of age.
Full-length sequencing of the thrombomodulin (TM) gene was obtained in 20 patients with premature acute myocardial infarction (AMI). Clinically relevant polymorphisms were identified and further evaluated in 145 patients with premature AMI and 143 controls. Despite the fact that TM promoter G-33A and C1418T polymorphisms are common in the Chinese population, the association between G-33A mutation and premature AMI indicates that we must focus on promoter G-33A polymorphism rather than C1418T polymorphism in terms of the role of TM gene mutation on premature AMI.
Chao
Ting-Hsing
TH
Department of Internal Medicine, Tainan, Taiwan.
Li
Yi-Heng
YH
Chen
Jyh-Hong
JH
Wu
Hua-Lin
HL
Shi
Guey-Yueh
GY
Tsai
Wei-Chuan
WC
Chen
Pin-Shern
PS
Liu
Ping-Yen
PY
D000367:Age Factors; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D018180:Thrombomodulin / Q000235:genetics*
D018180:Thrombomodulin