Dietary restriction and fibre supplementation: oxidative stress and metabolic shifting for cardiac health.
Dietary modification ought to be the first line of strategy in prevention of the development of cardiac disease. The purpose of this study was to investigate whether dietary restriction, dietary-fibre-enriched diet, and their interactions might affect antioxidant capacity and oxidative stress in cardiac tissue. Male Wistar rats (180-200 g; n=10) were divided into four groups: control ad libitum diet (C), 50% restricted diet (DR), fed with fibre-enriched diet (F), and 50% restricted fibre-enriched diet (DR-F). After 35 days of the treatments, F, DR, and DR-F rats showed low cholesterol, LDL-cholesterol, and triacylglycerol, and high HDL-cholesterol in serum. The DR, DR-F, and F groups had decreased myocardial lipoperoxide and lipid hydroperoxide. The DR-F and F treatments increased superoxide dismutase and glutatione peroxidase (GSH-Px). The DR treatment increased GSH-Px and catalase activities. Dietary fibre beneficial effects were related to metabolic alterations. The F and DR-F groups showed high cardiac glycogen and low lactate dehydrogenase/citrate synthase ratios, indicating diminished anaerobic and elevated aerobic myocardial metabolism in these animals. There was no synergistic effect between dietary restriction and dietary fibre addition, since no differences were observed in markers of oxidative stress in the F and DR-F groups. Dietary fibre supplementation, rather than energy intake and dietary restriction, appears to be the main process retarding oxidative stress in cardiac tissue.
Diniz
Yeda S
YS
Faculty of Medicine, UNESP, Botucatu, São Paulo, Brazil.
Cicogna
Antonio C
AC
Padovani
Carlos R
CR
Silva
Maeli D P
MD
Faine
Luciane A
LA
Galhardi
Cristiano M
CM
Rodrigues
Hosana G
HG
Novelli
Ethel L B
EL
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D031204:Caloric Restriction / Q000379:methods*; D004043:Dietary Fiber / Q000008:administration & dosage / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D004043:Dietary Fiber