Leukoaraiosis and mobility decline: a high resolution magnetic resonance imaging study in older people with mild cognitive impairment.
Patterns of leukoaraiosis were analyzed on both T2-weighted fast fluid-attenuated inversion-recovery and 3D T1-weighted sequences in 23 community-dwelling older subjects with mild cognitive impairment. Mobility assessment had allowed their classification into higher and lower mobility groups (P<0.0001). Lower mobility appeared correlated with frontal subependymal lesions (P=0.0005). The absence of marked ventriculomegaly, any thick caps, deep white matter lesions curved along the ventricles bodies, large deep white matter lesions, deep grey matter leukoaraiosis was an hallmark of the higher mobility group (P<0.0001). High resolution MRI demonstrated regular patterns of the subependymal lesions and detected perivascular distribution in other forms of leukoaraiosis. It suggests that the underlying mechanism of mobility decline in the elderly may be impairment of cerebrospinal fluid dynamics with cerebral small vessel disease.
Onen
Fannie
F
Department of Geriatrics, Biostatistics and Clinical Research, Bichat-Claude Bernard University Hospital, AP-HP, 46 rue Henri Huchard, 75877 Paris Cedex 18, France. fannie.onen@bch.ap-hop-paris.fr
Feugeas
Marie Cécile Henry
MC
Baron
Gabriel
G
De Marco
Giovanni
G
Godon-Hardy
Sylvie
S
Peretti
Ilana Idy
II
Ravaud
Philippe
P
Legrain
Sylvie
S
Moretti
Jean Luc
JL
Claeys
Elisabeth Schouman
ES
D000368:Aged; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D019957:Motor Skills Disorders / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000473:pathology; D009186:Myelin Sheath / Q000473:pathology*