title: [Population-genetic structure of Chuvashia (from data on eight DNA loci in the nuclear genome)].
abstract: Population-genetic study of indigenous populations representing three ethnic Chuvash group: highland (Cheboksarsk and Morgaush district), lowland (Kanash district) and mid-lowland (Marposad district). Eight polymorphic DNA loci of the nuclear genome (VNTR/PAH, STR/PAH, VNTR/ApoB, VNTR/DAT1, APF, VNTR/eNOS, IVS6aGATT, and KM.19/PstI) were examined in the population of each district. For each of the four population, we estimated the allele and genotype frequency distributions at each polymorphic system, heterozygosities HS and between-population differences FST. In the combined Chuvash sample, HS = 0.464 and FST = 0.006. Loci VNTR(DAT) and VNTR(ApoB) showed highest between-population differentiation (0.009 < or = FST < or = 0.012), and loci IVS6aGATT, APF, VNTR/eNOS, and D7S23 (KM.19), lowest differentiation (0.001 < or = FST < or = 0.003). Analysis of genetic distances revealed somewhat higher genetic similarity between the Cheboksarsk and Morgaush populations belonging to the highland Chuvash group, whereas the highland Chuvash population from the Marposad district, which belong to the mid-lowland group, was more distant from the former populations.
authors.affiliation: Institute of Biochemistry and Genetics, Russian Academy of Sciences, Ufa, 450054 Bashkortostan, Russia. ekkh@anrb.ru
authors.forename: E K
authors.initials: EK
authors.lastname: Khusnutdinova
authors.forename: T V
authors.initials: TV
authors.lastname: Viktorova
authors.forename: V L
authors.initials: VL
authors.lastname: Akhmetova
authors.forename: O E
authors.initials: OE
authors.lastname: Mustafina
authors.forename: R I
authors.initials: RI
authors.lastname: Fatkhlislamova
authors.forename: E V
authors.initials: EV
authors.lastname: Balanovskaia
authors.forename: N V
authors.initials: NV
authors.lastname: Petrova
authors.forename: S V
authors.initials: SV
authors.lastname: Makarov
authors.forename: O I
authors.initials: OI
authors.lastname: Kravchuk
authors.forename: G V
authors.initials: GV
authors.lastname: Paĭ
authors.forename: E K
authors.initials: EK
authors.lastname: Ginter
mesh_terms: D001483:Base Sequence; D002467:Cell Nucleus / Q000235:genetics*; D002874:Chromosome Mapping; D004247:DNA / Q000235:genetics*; D017931:DNA Primers; D005828:Genetics, Population; D006801:Humans; D011110:Polymorphism, Genetic; D012426:Russia
chemical_list: D017931:DNA Primers; D004247:DNA