[Effect of danshao granule on serum superoxide dismutase activity and malonyldialdehyde content in children with Henoch-Schonlein purpura nephritis].
OBJECTIVE
To explore the effect and mechanism of Danshao Granule (DSG) in treating Henoch-Schonlein purpura nephritis (HSPN) in children.


METHODS
The 63 patients with HSPN were randomly divided into two groups. The 32 patients in the treated group were treated with DSG and the 31 patients in the control group were treated with Tripterygium polyglycosides tablet and composite Salviae tablet. The therapeutic course for both groups was one month. The skin purpura, macroscopic hematuria, hypertension and edema subsidence time, 24 hrs urinary protein content, serum levels of immunoglobulins (IgA, IgG, IgM), superoxide dismutase (SOD) activity and malonyldialdehyde (MDA) content were observed before and after treatment.


RESULTS
Therapeutic effect in the treated group was better than that in the control group in curing skin purpura and macroscopic hematuria (P < 0.05). The 24 hrs urinary protein content and serum levels of IgA, SOD and MDA were improved after treatment in both groups significantly (P < 0.01). However, the improvement of 24 hrs urinary protein, serum SOD and MDA in the treated group was more significant than that in the control group respectively (P < 0.05).


CONCLUSIONS
DSG can alleviate the injury of free radicals in organism, so it is an ideal remedy for treatment of HSPN.
Jin
Zhong-da
ZD
First Hospital Affiliated to Nanjing TCM University, Nanjing 210029. jinzhongda@sohu.com
Wang
Shou-chuan
SC
Sun
Yi-qiu
YQ
D000293:Adolescent; D002648:Child; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009393:Nephritis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D008517:Phytotherapy; D027561:Salvia miltiorrhiza; D013482:Superoxide Dismutase / Q000097:blood*
D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D013482:Superoxide Dismutase