Case for postoperative surveillance following colorectal cancer resection.
Over 4 years have elapsed since the first National Health and Medical Research Council (NHMRC) guidelines were published for the management of patients after potentially curative resection of colorectal cancer. New information has now been published indicating that more intensive follow up than was originally recommended might provide a survival benefit for patients. This new information should be considered when formulating new NHMRC guidelines. In particular, meta-analyses of published individual trials have suggested a survival advantage that was not evident in the individual studies. There have been significant developments in chemotherapy with new individual agents and use of agents in combination that have proved far more effective than previous protocols. The therapeutic effect of these developments is the downstaging of some patients with metastatic disease, which was previously unresectable, to undergo resection. Furthermore, there is now some evidence that palliation of patients with advanced disease is more effective if commenced before the development of symptoms and this needs to be considered in the assessment of the benefits of follow up. There have been limited studies of cost-effectiveness, but international analyses suggest that the costs associated with more intensive follow-up regimes are within the accepted cost parameters associated with the management of many other conditions.
Worthington
Tim R
TR
Flinders Medical Centre, GI Surgery, Adelaide, South Australia, Australia.
Wilson
Tom
T
Padbury
Robert
R
D015179:Colorectal Neoplasms / Q000601:surgery*; D005500:Follow-Up Studies; D019983:Guideline Adherence; D006801:Humans; D011159:Population Surveillance; D017410:Practice Guidelines as Topic