title: [Macrocephaly and multiple hamartoma: a very variable entity].
abstract: The Bannayan-Zonana is a dominant autosomal polymalformation syndrome.
  
  
  METHODS
  We report a case of Bannayan-Zonana syndrome in a 3-year-old girl, who presented with macrocephaly and a cervical lipoma. The patient's mother had neurofibromatosis I. No mutation in the PTEN gene was found. The slowly progressive lipoma increased with age and the surgical reduction was necessary.
  
  
  CONCLUSIONS
  Macrocephaly is constant in different syndromes characterized with multiple hamartomas. The multiple hamartomas syndrome represents an entity with a high variability of expression.
authors.affiliation: Service de chirurgie pédiatrique, centre hospitalo-universitaire de Poitiers, 350, avenue Jacques-Coeur, BP 577, 86021 Poitiers, France. j.mcheik@chu-poitiers.fr
authors.forename: J N
authors.initials: JN
authors.lastname: Mcheik
authors.forename: M P
authors.initials: MP
authors.lastname: Cordier
authors.forename: M
authors.initials: M
authors.lastname: Longy
authors.forename: G
authors.initials: G
authors.lastname: Levard
mesh_terms: D002675:Child, Preschool; D019465:Craniofacial Abnormalities / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006222:Hamartoma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008067:Lipoma / Q000473:pathology* / Q000601:surgery; D009333:Neck / Q000473:pathology; D013577:Syndrome