title: Refractory rhinosinusitis complicating immunosuppression: application of N-chlorotaurine, a novel endogenous antiseptic agent.
abstract: Severe infections are a frequent complication in immunosuppression following transplantations. In the case reported here, a heart-transplanted patient was treated for refractory rhinosinusitis with a combination of sinus surgery and rinsing with N-chlorotaurine (NCT). The daily rinse was well tolerated and effective. The combination of functional endonasal sinus surgery and topical treatment with NCT appeared effective and well tolerated in antibiotic-resistant sinusitis under immunosuppression.
authors.affiliation: Department of Otorhinolaryngology, Leopold-Franzens University of Innsbruck, Innsbruck, Austria.
authors.forename: Michaela
authors.initials: M
authors.lastname: Gstöttner
authors.forename: Markus
authors.initials: M
authors.lastname: Nagl
authors.forename: Claus
authors.initials: C
authors.lastname: Pototschnig
authors.forename: Andreas
authors.initials: A
authors.lastname: Neher
mesh_terms: D000293:Adolescent; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D018836:Inflammation Mediators / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008443:Maxillary Sinus / Q000601:surgery*; D013517:Otorhinolaryngologic Surgical Procedures; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D012220:Rhinitis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D012852:Sinusitis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery; D013654:Taurine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D007507:Therapeutic Irrigation
chemical_list: D000891:Anti-Infective Agents, Local; D018836:Inflammation Mediators; D013654:Taurine; C043410:N-chlorotaurine