title: Clinical trials for pulmonary metastasectomy.
abstract: There remains great controversy as to the indications and true benefits for pulmonary metastasectomy. The number of metastatic lesions, length of disease-free interval, and unilaterality has shown to be important prognostic factors on overall survival. In this review, we evaluate a number of clinical trials and critically assess the rational to perform pulmonary metastasectomy, which is a local treatment for a systemic disease process.
authors.affiliation: Section of Thoracic Surgery, University of Pittsburgh Medical Center, PA 15213, USA.
authors.forename: Amit N
authors.initials: AN
authors.lastname: Patel
authors.forename: Jason
authors.initials: J
authors.lastname: Lamb
authors.forename: Nilesh
authors.initials: N
authors.lastname: Patel
authors.forename: Ricardo S
authors.initials: RS
authors.lastname: Santos
authors.forename: Christos
authors.initials: C
authors.lastname: Stavropoulos
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Landreneau
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D002986:Clinical Trials as Topic; D018572:Disease-Free Survival; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary / Q000601:surgery*; D011013:Pneumonectomy
chemical_list: D014408:Biomarkers, Tumor