T-cell activation.
Activation of T lymphocytes results in immediate intracellular biochemical changes, including increases in cytosolic Ca(2+) levels, stimulation of protein kinase C (PKC) and regulation of protein tyrosine kinases (PTKs). This review describes recent advances in the study of the signalling steps downstream of PKC and PTKs in T cells. A model is presented in which the GTP-binding protein p21(ras) acts as an integrator of the signal transduction pathways controlled by the T-cell antigen receptor.
Izquierdo
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The authors are at the Lymphocyte Activation Laboratory, ICRF Laboratories, PO Box 123, Lincoln's, Inn Fields, London, UK WC2A 3PX.
Cantrell
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DA