Levofloxacin treatment failure in Haemophilus influenzae pneumonia.
We describe the first case of failure of oral levofloxacin treatment of community-acquired pneumonia caused by Haemophilus influenzae. The strain showed cross-resistance to fluoroquinolones and carried four mutations in quinolone resistance-determining regions of DNA gyrase and topoisomerase IV genes.
Bastida
Teresa
T
Hospital de l'Esperit Sant, Santa Coloma de Gramenet, Barcelona, Spain.
Pérez-Vázquez
María
M
Campos
José
J
Cortés-Lletget
María Cristina
MC
Román
Federico
F
Tubau
Fe
F
de la Campa
Adela G
AG
Alonso-Tarrés
Carles
C
D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D017714:Community-Acquired Infections / Q000188:drug therapy*; D027081:DNA Gyrase / Q000187:drug effects / Q000235:genetics*; D016521:Electrophoresis, Gel, Pulsed-Field; D017809:Fatal Outcome; D005260:Female; D006192:Haemophilus Infections / Q000188:drug therapy*; D006193:Haemophilus influenzae / Q000187:drug effects / Q000235:genetics*; D006801:Humans; D064704:Levofloxacin; D008969:Molecular Sequence Data; D015242:Ofloxacin / Q000627:therapeutic use*; D011014:Pneumonia / Q000188:drug therapy* / Q000382:microbiology; D017211:Treatment Failure
D000890:Anti-Infective Agents; D064704:Levofloxacin; D015242:Ofloxacin; D027081:DNA Gyrase