A genome analysis of endoreplication in the Drosophila ovary.
Gene amplification is used by follicle cells to increase the copy number of Drosophila chorion genes, which encode structural components of the eggshell. A new study by Claycomb et al. in this issue of Developmental Cell raises the possibility that gene amplification might also be used for the developmental patterning of the egg chamber and oocyte.
Botchan
Mike
M
Department of Molecular & Cell Biology, Division of Biochemistry & Molecular Biology, University of California-Berkeley, Berkeley, CA 94720, USA.
Levine
Mike
M
D000818:Animals; D019521:Body Patterning / Q000235:genetics; D004261:DNA Replication / Q000235:genetics*; D004331:Drosophila melanogaster / Q000166:cytology / Q000196:embryology* / Q000235:genetics; D005260:Female; D005784:Gene Amplification / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D009866:Oogenesis / Q000235:genetics*; D006080:Ovarian Follicle / Q000166:cytology / Q000378:metabolism; D011123:Polyploidy