title: [Disease mechanisms in coeliac disease].
abstract: Coeliac disease is a chronic inflammatory disorder that is caused by an inappropriate immune response in the gut to wheat gluten and similar proteins of barley and rye. The disease has a multifactorial aetiology involving multiple genes and environmental factors. In recent years we have gained new knowledge of the molecular basis of this disorder; this paper gives an overview of the current understanding of the pathogenesis of coeliac disease.
authors.affiliation: Immunologisk institutt, Rikshospitlet, Oslo. l.m.sollid@labmed.uio.no
authors.forename: Ludvig M
authors.initials: LM
authors.lastname: Sollid
authors.forename: Knut E A
authors.initials: KE
authors.lastname: Lundin
mesh_terms: D002446:Celiac Disease / Q000178:diet therapy / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D020022:Genetic Predisposition to Disease; D005983:Glutens / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology / Q000473:pathology; D007421:Intestine, Small / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D006680:HLA Antigens; D005983:Glutens