Serum lipid and lipoprotein changes induced by preparations containing low-dose ethinylestradiol plus levonorgestrel.
The purpose of the present study was to evaluate the effects on lipid metabolism of a new low-dose monophasic combination oral contraceptive with 100 microg levonorgestrel and 20 microg ethinylestradiol. Sixty healthy women aged 18-45 years were administered the medication during three cycles. The study participants were screened for lipid changes. The differences in cholesterol and triglyceride levels were not statistically significant, but high-density lipoprotein levels were significantly lower and low-density lipoprotein levels were significantly higher than the baseline. Women at risk of cardiovascular disease should be carefully monitored even when using low-dose preparations.
Kiran
Gurkan
G
Department of Obstetrics and Gynaecology, Faculty of Medicine, Kahramanmaras Sutcuimam University, Kahramanmaras, Turkey. gurkankiran@mail.ksu.edu.tr
Kiran
Hakan
H
Ekerbicer
Hasan C
HC
D000328:Adult; D003276:Contraceptives, Oral; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage*; D008074:Lipoproteins / Q000097:blood*; D014280:Triglycerides / Q000097:blood*
D003276:Contraceptives, Oral; D004338:Drug Combinations; D008074:Lipoproteins; D014280:Triglycerides; D004997:Ethinyl Estradiol; D016912:Levonorgestrel