title: Structure, function and assembly of the nucleolus.
abstract: Most events of ribosome biogenesis--such as transcription of the ribosomal RNA (rRNA) genes, processing of their primary transcripts into mature rRNAs and assembly with ribosomal and nonribosomal proteins to form the preribosomes--are confined to a special nuclear compartment, the nucleolus. Immunogold labelling and in situ hybridization at the ultrastructural level are providing novel insights into structure-function relationships of the nucleolus, and in vitro systems are beginning to shed light on the molecular mechanisms involved in the reforming of nucleoli after mitosis.
authors.affiliation: Department of Cell and Developmental Biology, Theodor-Boveri-Institute, University of Würzburg, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Scheer
authors.forename: M
authors.initials: M
authors.lastname: Thiry
authors.forename: G
authors.initials: G
authors.lastname: Goessens