title: Understanding SARS with Wolfram approach.
abstract: Stepping acquired immunodeficiency syndrome (AIDS), severe acute respiratory syndrome (SARS) as another type of disease has been threatening mankind since late last year. Many scientists worldwide are making great efforts to study the etiology of this disease with different approaches. 13 species of SARS virus have been sequenced. However, most people still largely rely on the traditional methods with some disadvantages. In this work, we used Wolfram approach to study the relationship among SARS viruses and between SARS viruses and other types of viruses, the effect of variations on the whole genome and the advantages in the analysis of SARS based on this novel approach. As a result, the similarities between SARS viruses and other coronaviruses are not really higher than those between SARS viruses and non-coronaviruses.
authors.affiliation: Bio-X Life Science Research Center, Shanghai Jiao Tong University, Shanghai 200030, China.
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Li
authors.forename: Yu-Xi
authors.initials: YX
authors.lastname: Pan
authors.forename: Yun
authors.initials: Y
authors.lastname: Duan
authors.forename: Zhen-De
authors.initials: ZD
authors.lastname: Hung
authors.forename: Ming-Qing
authors.initials: MQ
authors.lastname: Xu
authors.forename: Lin
authors.initials: L
authors.lastname: He
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D030541:Databases, Genetic; D020869:Gene Expression Profiling / Q000379:methods*; D015967:Gene Expression Regulation, Viral / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D045473:Severe acute respiratory syndrome-related coronavirus / Q000145:classification* / Q000235:genetics*; D016415:Sequence Alignment / Q000379:methods*; D017422:Sequence Analysis, DNA / Q000379:methods*; D012689:Sequence Homology, Nucleic Acid