Triacylglycerols based on 2-(N-tert-butoxycarbonylamino)oleic acid are potent inhibitors of pancreatic lipase.
A novel class of potent human pancreatic lipase (HPL) inhibitors was developed. Triacylglycerol analogues containing 2-(N-tert-butoxycarbonylamino) fatty acids were synthesized, and their ability to form stable films at the air/water interface was studied. The inhibition of human digestive lipases by the compounds synthesized was studied by the monolayer technique, and the triesters of glycerol and 2-methylglycerol with 2-(N-tert-butoxycarbonylamino)oleic acid were found to be potent inhibitors of HPL.
Magrioti
Victoria
V
Chemical Laboratories, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece.
Verger
Robert
R
Constantinou-Kokotou
Violetta
V
D006801:Humans; D008049:Lipase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D009829:Oleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D010179:Pancreas / Q000737:chemistry*; D013270:Stomach / Q000737:chemistry; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000138:chemical synthesis* / Q000737:chemistry*
D009829:Oleic Acids; D014280:Triglycerides; D008049:Lipase