title: Hypocholesterolemic property of Yucca schidigera and Quillaja saponaria extracts in human body.
abstract: This study was undertaken to observe the effects of the blend of partially purified Yucca schidigera and Quillaja saponaria extracts on cholesterol levels in the human's blood and gastrointestinal functions, and to determine if a new cholesterol-lowering drug can be developed by the further purification of the extracts. Ultrafiltration and sequential diafiltration increased the amounts of steroidal saponin in aqueous yucca extract and terpenoid saponin in aqueous quillaja extract from 9.3% and 21.4% to 17.2% and 61.8%, respectively. Taking 0.9 mg of the blend (6:4, v:v) of the resulting filtrates a day for 4 weeks resulted in the decreases in total and LDL cholesterol levels in blood plasma of hyper-cholesterolemic patients with enhancement in gastrointestinal symptoms of patients.
authors.affiliation: Division of Endocrinology & Metabolism, Department of Medicine, Miz Medi Hospital, Seoul, Korea.
authors.forename: Sang-Woo
authors.initials: SW
authors.lastname: Kim
authors.forename: Sang-Kyu
authors.initials: SK
authors.lastname: Park
authors.forename: Sung-Il
authors.initials: SI
authors.lastname: Kang
authors.forename: Han-Chul
authors.initials: HC
authors.lastname: Kang
authors.forename: Han-Jin
authors.initials: HJ
authors.lastname: Oh
authors.forename: Chul-Young
authors.initials: CY
authors.lastname: Bae
authors.forename: Dong-Ho
authors.initials: DH
authors.lastname: Bae
mesh_terms: D000924:Anticholesteremic Agents / Q000009:adverse effects / Q000302:isolation & purification / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004311:Double-Blind Method; D004338:Drug Combinations; D005769:Gastrointestinal Motility / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008875:Middle Aged; D008517:Phytotherapy / Q000379:methods; D024301:Plant Bark; D010946:Plants, Medicinal / Q000737:chemistry*; D031990:Quillaja; D027623:Yucca
chemical_list: D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D004338:Drug Combinations; D002784:Cholesterol