Absence of factor V Leiden (G1691A) mutation, FII G20210A allele in coronary artery disease in North India.
BACKGROUND
Interaction between various genetic and environmental factors is associated with coronary artery diseases (CADs). Factor V Leiden mutation (FVL) and FII G20210A polymorphism are two recently described genetic factors with a propensity towards venous thrombosis, however, with a doubtful role in coronary artery disease and myocardial infarction.


OBJECTIVE
Present study was conducted to assess the relationship of both these factors in coronary artery disease in population from North India.


METHODS
Case control study.


METHODS
Two hundred angiographically proven coronary artery disease patients were studied to examine the association of Factor V Leiden mutation and FII G20210A mutation with coronary artery disease and myocardial infarction. Out of 200 patients, 51 had myocardial infarction. Two hundred controls were selected who were from north India and were also age and sex matched.


CONCLUSIONS
Our results indicate that both these polymorphisms were totally absent in our population, therefore, these variants cannot be considered as independent risk factors or as a predictor for CAD. However, there is a need to confirm the above findings on patients from different populations from different parts of the country as there are reports which show that the incidence of Factor V Leiden varies from 1.3 % to 10%.
Gupta
N
N
Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Rai Bareilly Road, Lucknow - 226 014, India.
Khan
F
F
Tripathi
M
M
Singh
V P
VP
Tewari
S
S
Ramesh
V
V
Sinha
N
N
Agrawal
S
S
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D017354:Point Mutation
C095381:factor V Leiden; D005165:Factor V