The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity.
IGF-1 and growth hormone (GH) interact with insulin to modulate its control of carbohydrate metabolism. A new study (see the related article beginning on page 96) shows that blocking the effect of GH in the presence of low serum IGF-1 concentrations enhances insulin sensitivity.
Clemmons
David R
DR
Department of Medicine, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA. endo@medicineexch.med.unc.edu
D000818:Animals; D013006:Growth Hormone / Q000494:pharmacology / Q000502:physiology; D019382:Human Growth Hormone / Q000502:physiology*; D007328:Insulin / Q000494:pharmacology* / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000172:deficiency / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout
D007328:Insulin; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone