title: Long-term survival following postmastectomy locoregional recurrence of breast cancer.
abstract: Only a few reports describe long-term survivors following locoregional recurrence of breast cancer after mastectomy. We analyzed 145 patients who were treated for an isolated postmastectomy breast cancer recurrence at our department between 1979 and 1992. All patients were free from distant metastases at the time of recurrence. Nineteen of these patients remained free from distant metastases after a follow-up of more than 10 years following recurrence. Clinical and histopathological characteristics of these 19 patients were analyzed. Primary tumors were small with almost all being T1 or T2 primaries. The majority of survivors had negative axillary node status (16/19 [84%]). Locoregional recurrences were mainly chest wall recurrences (16/19 [84%]) and all recurrences were smaller than 5 cm (19/19). Only 7 patients showed a typical scar recurrence. Sixteen patients had a single recurrent nodule. Early recurrences (<1 year after mastectomy) were rare (n=2). Treatment of recurrence consisted of tumor excision in all cases followed by radiotherapy in 16 patients (including 6 patients who had undergone elective irradiation following mastectomy), hormonal therapy in 6 and chemotherapy in 1 case. In all patients local control at the recurrence site was achieved. Cure after postmastectomy recurrence seems possible in a subgroup of patients (small primary tumor with negative axilla, small and solitary chest wall recurrence) provided adequate therapy is prescribed. Treatment of these patients should not be regarded as palliative therapy.
authors.affiliation: Department of Radiotherapy, University of Wuerzburg, Josef-Schneider-Str 11, D-97080 Wuerzburg, Germany. willner@strahlentherapie.uni-wuerzburg.de
authors.forename: J
authors.initials: J
authors.lastname: Willner
authors.forename: I C
authors.initials: IC
authors.lastname: Kiricuta
authors.forename: O
authors.initials: O
authors.lastname: Kölbl
authors.forename: M
authors.initials: M
authors.lastname: Flentje