Anti-inflammatory effects of fructose-1,6-bisphosphate on carrageenan-induced pleurisy in rat.
In the present study, we evaluated the effect of fructose-1,6-bisphosphate (FBP), a high energy intermediate metabolite of glycolysis, in an acute model of lung injury. Injection of carrageenan into the pleural cavity of rats elicited an acute inflammation response characterized by a fluid accumulation in the pleural cavity which contained a large number of polymorphonuclear neutrophils. FBP (500mg/kg) attenuated the inflammation parameters: exudate volume, total leukocytes and the number of polymorphonuclear leukocytes, but the protein concentration in the exudate was not significantly affected by treatment with FBP. The precise site and mechanism of the anti-inflammatory effect was not addressed, considering the diverse pharmacological actions of FBP. This drug has anti-inflammatory actions suggesting that it may represent a novel strategy for the modulation of inflammatory response.
Alves Filho
José Carlos Farias
JC
Laboratório de Pesquisa em Biofísica, Departamento de Ciências Fisiológicas, Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul, Av. Ipiranga, 6681, Prédio 12C-Sala 263, C.P.1429, RS, Porto Alegre, Brazil.
Santos
Roberto Christ Vianna
RC
Castaman
Telmo Abelin
TA
de Oliveira
Jarbas Rodrigues
JR
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D044723:Chondrus; D005260:Female; D005635:Fructosediphosphates / Q000627:therapeutic use*; D010998:Pleurisy / Q000139:chemically induced* / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005635:Fructosediphosphates; C029063:fructose-1,6-diphosphate