Solution structure of a BolA-like protein from Mus musculus.
The BolA-like proteins are widely conserved from prokaryotes to eukaryotes. The BolA-like proteins seem to be involved in cell proliferation or cell-cycle regulation, but the molecular function is still unknown. Here we determined the structure of a mouse BolA-like protein. The overall topology is alphabetabetaalphaalphabetaalpha, in which beta(1) and beta(2) are antiparallel, and beta(3) is parallel to beta(2). This fold is similar to the class II KH fold, except for the absence of the GXXG loop, which is well conserved in the KH fold. The conserved residues in the BolA-like proteins are assembled on the one side of the protein.
Kasai
Takuma
T
Protein Research Group, RIKEN Genomic Sciences Center, 1-7-22 Suehiro-cho, Tsurumi, Yokohama 230-0045, Japan.
Inoue
Makoto
M
Koshiba
Seizo
S
Yabuki
Takashi
T
Aoki
Masaaki
M
Nunokawa
Emi
E
Seki
Eiko
E
Matsuda
Takayoshi
T
Matsuda
Natsuko
N
Tomo
Yasuko
Y
Shirouzu
Mikako
M
Terada
Takaho
T
Obayashi
Naomi
N
Hamana
Hiroaki
H
Shinya
Naoko
N
Tatsuguchi
Ayako
A
Yasuda
Satoko
S
Yoshida
Mayumi
M
Hirota
Hiroshi
H
Matsuo
Yo
Y
Tani
Kazutoshi
K
Suzuki
Harukazu
H
Arakawa
Takahiro
T
Carninci
Piero
P
Kawai
Jun
J
Hayashizaki
Yoshihide
Y
Kigawa
Takanori
T
Yokoyama
Shigeyuki
S
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D019906:Nuclear Magnetic Resonance, Biomolecular; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid; D012996:Solutions / Q000737:chemistry
C490226:BolA2 protein, mouse; D011506:Proteins; D012996:Solutions