title: Prognostic significance of microsatellite instability in curatively resected adenocarcinoma of the small intestine.
abstract: Adenocarcinoma of the small intestine (ACSI) is a rare condition with few studies addressing follow-up and prognosis. Tumors of 35 patients with curative resection of an ACSI were retrospectively analyzed by immunohistochemistry: p53, hMLH1, hMSH2 and hMSH6 and microsatellite instability (MSI): BAT-26, BAX, TGF-beta RII. With a median follow up of 6.1 years, the median cancer-specific survival (CSS) was 36.2 months. Patients who were highly instable (MSI-H) (n=10) had a CSS of 49.6 months in contrast to patients with stable tumors (23.2 months) (P=0.010). Additionally, a low tumor stage according to UICC and MSI-H were shown to be independent factors (P=0.005 and P<0.001) for an increased survival in multivariate analysis. Therefore, it is suggested that analysis of the MSI status might prove useful in discerning prognosis within cancers of the same stage.
authors.affiliation: Department of Internal Medicine I, Friedrich-Alexander-University, Ulmenweg 18, Erlangen-Nuremberg, D-91054 Erlangen, Germany. wolfgang.brueckl@med1.imed.uni-erlangen.de
authors.forename: Wolfgang M
authors.initials: WM
authors.lastname: Brueckl
authors.forename: Elvira
authors.initials: E
authors.lastname: Heinze
authors.forename: Catrin
authors.initials: C
authors.lastname: Milsmann
authors.forename: Axel
authors.initials: A
authors.lastname: Wein
authors.forename: Corinna
authors.initials: C
authors.lastname: Koebnick
authors.forename: Andreas
authors.initials: A
authors.lastname: Jung
authors.forename: Roland S
authors.initials: RS
authors.lastname: Croner
authors.forename: Thomas
authors.initials: T
authors.lastname: Brabletz
authors.forename: Klaus
authors.initials: K
authors.lastname: Günther
authors.forename: Thomas
authors.initials: T
authors.lastname: Kirchner
authors.forename: Eckhart G
authors.initials: EG
authors.lastname: Hahn
authors.forename: Werner
authors.initials: W
authors.lastname: Hohenberger
authors.forename: Heinz
authors.initials: H
authors.lastname: Becker
authors.forename: Bertram
authors.initials: B
authors.lastname: Reingruber
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020137:Base Pair Mismatch; D004260:DNA Repair; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007414:Intestinal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000601:surgery; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53