Studies on the antibacterial potentiality of isoflavones.
The isoflavonoid compounds 'YS11-YS21' were screened for possible antimicrobial property against 12 known Gram-positive and Gram-negative sensitive bacteria. YS11 and YS16 failed to show antimicrobial activity and YS12, 13, 14, 15, 17, 18 and 20 had moderate antimicrobial action. Compounds YS19 and YS21 showed pronounced antimicrobial property. YS19 and YS21 were then tested in vitro against 214 strains of bacteria from one Gram-positive and six Gram-negative genera. The minimum inhibitory concentration (MIC) of YS19 and YS21 was determined by agar dilution method and ranged from 25 to 200 mg/l in most strains. At concentrations of 30 and 60 microg/mouse these compounds offered significant protection to mice challenged with 50 median lethal dose (MLD) of a virulent strain of Salmonella Typhimurium.
Dastidar
Sujata G
SG
Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India.
Manna
A
A
Kumar
K Asok
KA
Mazumdar
Kaushiki
K
Dutta
N K
NK
Chakrabarty
A N
AN
Motohashi
Noboru
N
Shirataki
Yoshiaki
Y
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D007529:Isoflavones / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D008826:Microbial Sensitivity Tests; D012481:Salmonella Infections, Animal / Q000188:drug therapy; D012486:Salmonella typhimurium / Q000187:drug effects
D000900:Anti-Bacterial Agents; D007529:Isoflavones