title: Antidiabetic activity of Bauhinia forficata extracts in alloxan-diabetic rats.
abstract: The antidiabetic activity of aqueous, ethanolic and hexanic extracts of Bauhinia forficata was investigated in a model of alloxan-induced diabetes in rats. The biochemical parameters studied were: plasma glucose, serum triglycerides, cholesterol, high density lipoprotein (HDL), and low density lipoprotein (LDL). Extracts were administered daily for 7 d at doses of 200 and 400 mg/kg, p.o., 48 h after alloxan injection (60 mg/kg, i.v.). The alloxan-diabetic rats showed significant reductions in plasma glucose, triglycerides, total cholesterol and HDL-cholesterol after treatment with the extracts and glibenclamide (used as standard) as compared to the diabetic controls. Levels of LDL were not altered. In conclusion, our results showed that the plant extracts when administered by gavage may reduce glucose, triglycerides, total cholesterol and HDL-cholesterol levels. These results suggest the validity of the clinical use of B. forficata in the treatment of diabetes mellitus type II.
authors.affiliation: Department of Physiology and Pharmacology, Federal University of Ceará, Coronel Nunes de Melo 1127, 60430-270 Fortaleza, Ceará, Brazil. cleidelino@yahoo.com.br
authors.forename: Cleide de Sousa
authors.initials: Cde S
authors.lastname: Lino
authors.forename: João Paulo Luz
authors.initials: JP
authors.lastname: Diógenes
authors.forename: Bruno Azevedo
authors.initials: BA
authors.lastname: Pereira
authors.forename: Rozilaine Aparecida Pelegrine Gomes
authors.initials: RA
authors.lastname: Faria
authors.forename: Manoel
authors.initials: M
authors.lastname: Andrade Neto
authors.forename: Renata Sousa
authors.initials: RS
authors.lastname: Alves
authors.forename: Maria Goreti Rodrigues
authors.initials: MG
authors.lastname: de Queiroz
authors.forename: Francisca Cléa Florenço
authors.initials: FC
authors.lastname: de Sousa
authors.forename: Glauce Socorro Barros
authors.initials: GS
authors.lastname: Viana
mesh_terms: D000818:Animals; D036481:Bauhinia / Q000737:chemistry*; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D000431:Ethanol; D005905:Glyburide / Q000494:pharmacology; D006586:Hexanes; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008055:Lipids / Q000097:blood; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents; D014280:Triglycerides / Q000097:blood; D014867:Water
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D006586:Hexanes; D007004:Hypoglycemic Agents; D008055:Lipids; D010936:Plant Extracts; D012997:Solvents; D014280:Triglycerides; D014867:Water; D000431:Ethanol; D002784:Cholesterol; D005905:Glyburide