title: [Experimental study of the effect of Astragalus membranaceus against herpes simplex virus type 1].
abstract: OBJECTIVE
  To study the inhibitory effects of Astragalus membranaceus on herpes simplex virus type 1(HSV-1).
  
  
  METHODS
  In the 2BS cells infected with HSV-1, the antiviral effect of Astragalus membranaceus decoction was investigated by observing the inhibition of HSV-1-induced cytopathic effect in response to treatment with the decoction.
  
  
  RESULTS
  The half inhibition concentration (IC50) and minimal inhibition concentration (MIC) of Astragalus membranaceus were 0.98 and 1.95   g/ml respectively, with the therapeutic index (TI) of 128.
  
  
  CONCLUSIONS
  Astragalus membranaceus has obvious HSV-1-inhibiting efficacy and low cytotoxicity.
authors.affiliation: Department of Pharmaceutics, General Hospital of PLA, Beijing 100853, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D027883:Astragalus Plant; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts