Analysis of factors influencing the blood levels and activities of tissue-type plasminogen activator (t-PA).
This study aimed to correlate plasmatic tissue-type plasminogen activator (t-PA) levels and activity with parameters of artery blood flow and vessel walls, nail fold microcirculation, hemorheology, serum glucose, and lipids. Thirty healthy volunteers (female/male 12/18) aged 40-60 (average 46) were included in the study. In citrate venous blood, the following parameters were determined: carotid mean velocity, carotid intimal-medial-thickness (IMT), capillary circulation parameters, hemorheology index, serum glucose, and lipids. Analysis of data showed that t-PA concentration was positively and significantly correlated with total cholesterol, triglycerides, and serum glucose (P<0.05, P<0.05, and P<0.01), but t-PA activity showed no correlation with them; among the hemorheology factors investigated, t-PA concentration showed the strongest positive correlation with both whole blood viscosity and reduced blood viscosity at high and low shear rate separately (P<0.01), t-PA activity showed no correlation with any hemorheology factors; t-PA concentration showed no correlation with any investigated nail fold capillary parameters, whereas t-PA activity was significantly and negatively associated with capillary loop number (P<0.05); t-PA concentration and activity was not associated with values of carotid maximum intimal-medial-thickness (mIMT) and mean velocity or systolic, diastolic blood pressure (P>0.05). But subjects with mIMT 1.0 mm showed higher t-PA levels compared with those with mIMT < 1.0 mm (P<0.05) and decreased carotid mean velocity (P<0.01). These findings suggest that multiple vascular disease risk factors would influence the t-PA level; t-PA concentration does not parallelize with t-PA activity.
Wei
R
R
Institute of Basic Medical Science, Taishan Medical College, Taian, Shandong 271000, China.
Han
J J
JJ
Bai
B
B
Ren
D L
DL
Chen
B
B
Yang
M F
MF
Xia
Z L
ZL
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D001809:Blood Viscosity; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000502:physiology / Q000648:ultrastructure; D002784:Cholesterol / Q000097:blood; D005260:Female; D006400:Hematocrit; D018056:Hemorheology; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009262:Nails / Q000098:blood supply; D012016:Reference Values; D010959:Tissue Plasminogen Activator / Q000097:blood* / Q000502:physiology; D014280:Triglycerides / Q000097:blood; D017539:Tunica Intima / Q000648:ultrastructure; D017540:Tunica Media / Q000648:ultrastructure; D014463:Ultrasonography
D001786:Blood Glucose; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D010959:Tissue Plasminogen Activator