Suppression of graft-versus-host disease by naturally occurring regulatory T cells.
Studies of graft-versus-host disease after allogeneic bone marrow transplantation have shown that there are subsets of freshly isolated donor T cells that induce the disease and subsets that suppress the disease. The balance of subsets in the graft determines disease severity. The authors' work on the nature of the regulatory-suppressor T cells and their mechanisms of action is summarized in this article.
Zeng
Defu
D
Division of Rheumatology and Immunology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Lan
Fengshuo
F
Hoffmann
Petra
P
Strober
Samuel
S
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D016026:Bone Marrow Transplantation; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism / Q000502:physiology; D006086:Graft vs Host Disease / Q000517:prevention & control*; D006801:Humans; D007694:Killer Cells, Natural / Q000502:physiology; D015182:Lymphatic Irradiation; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D013601:T-Lymphocytes / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000166:cytology; D014184:Transplantation, Homologous
D015375:Receptors, Interleukin-2