[Pulmonary Infiltrate, Pleural Effusion and IgM Macroglobulinaemia].
We report a 71-year-old mam with known IgM- Macroglobulinemia, who developed infiltrative pulmonary changes and a pleural effusion. Both, the pleural effusion and bronchoalveolar lavage revealed monoclonal IgM positive B-lymphocytoes. Transbronchial biopsies showed tissue infiltrates of lymphoplasmocytic cells, consistent with a pleuropulmonary manifestation of Morbus Waldenstroem. Bone marrow and gastrointestinal involvement could be excluded, and the diagnosis of a primary pulmonary immunocytoma was made. The patient underwent partial lung resection with removal of the affected lung tissue. Pleuropulmonary changes in patients with IgM-Macroglobulinaemia or Morbus Waldenstroem may be due to pulmonary involvement by the hematological disease.
Reichenberger
F
F
Abteilung für Pneumologie, Zentrum für Innere Medizin. reichenf@hotmail.com
Heberlein
J U
JU
Müller
A
A
Wirtz
H
H
Schauer
J
J
D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology / Q000601:surgery; D008297:Male; D010996:Pleural Effusion / Q000209:etiology* / Q000276:immunology; D016896:Treatment Outcome; D008258:Waldenstrom Macroglobulinemia / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology*
D007075:Immunoglobulin M