[De novo hepatitis B with anti-HBc negative in a liver transplant recipient [corrected]].
De novo hepatitis B was diagnosed in a 47-year-old man 15 months after liver transplantation for end-stage alcoholic cirrhosis. Serum antibodies to hepatitis B core antigen (anti-HBc) were negative, and remained undetectable over 20 months of follow-up. The possible causes of negative serum anti-HBc despite of active hepatitis B virus infection are reviewed. Immunosuppression may underlie this phenomenon in similar cases.
Campos Franco
J
J
Servicio de Medicina Interna, Hospital Clínico Universitario, Santiago de Compostela, La Coruña, España. xkampos@hotmail.com
Otero Antón
E
E
González Quintela
A
A
Aguilera Guirao
A
A
Varo Pérez
E
E
D000917:Antibody Formation / Q000187:drug effects; D004279:DNA, Viral / Q000097:blood; D005188:False Negative Reactions; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000188:drug therapy; D006509:Hepatitis B / Q000175:diagnosis* / Q000276:immunology / Q000635:transmission; D006510:Hepatitis B Antibodies / Q000097:blood*; D006511:Hepatitis B Antigens / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D008104:Liver Cirrhosis, Alcoholic / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis* / Q000276:immunology / Q000821:virology; D016559:Tacrolimus / Q000494:pharmacology / Q000627:therapeutic use; D014766:Viremia / Q000175:diagnosis* / Q000276:immunology
D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens; D007166:Immunosuppressive Agents; D016559:Tacrolimus; D008775:Methylprednisolone