Upregulation of cardiac ghrelin mRNA in leptin-deficient and leptin receptor-deficient mice with viral myocarditis.
Expression of cardiac and gastric ghrelin messenger (m) RNA, together with heart and body weights, were measured in leptin-deficient (ob) and leptin receptor-deficient (db) mice with heart failure induced by viral myocarditis. Significant elevations in cardiac ghrelin mRNA levels and heart weight were observed in ob and db mice 10 days after viral inoculation compared with baseline values. Expression of gastric ghrelin mRNA was not upregulated in ob and db mice on day 10. The elevated expression of cardiac ghrelin mRNA seems to compensate for the lack of upregulation in gastric ghrelin mRNA.
Kanda
T
T
Department of General Medicine, Kanazawa Medical University, Ishikawa, Japan. kandat@kanazawa-med.ac.jp
Takahashi
T
T
Itoh
T
T
Kusaka
K
K
Yamakawa
J
J
Kudo
S
S
Takeda
T
T
Tsugawa
H
H
Takekoshi
N
N
D000818:Animals; D001835:Body Weight / Q000235:genetics; D015870:Gene Expression; D054439:Ghrelin; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology; D006333:Heart Failure / Q000209:etiology / Q000235:genetics; D020738:Leptin / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D008817:Mice, Mutant Strains; D009205:Myocarditis / Q000150:complications / Q000235:genetics* / Q000473:pathology; D036361:Peptide Hormones / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D054411:Receptors, Leptin; D013270:Stomach / Q000502:physiology; D015854:Up-Regulation; D014777:Virus Diseases / Q000150:complications / Q000235:genetics* / Q000473:pathology
D054439:Ghrelin; D020738:Leptin; D036361:Peptide Hormones; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; C515447:leptin receptor, mouse