Gastrointestinal polyposis in childhood: clinicopathologic and genetic features.
Gastrointestinal polyps and certain extraintestinal lesions in children may herald a hereditary polyposis syndrome, with an increased risk of neoplasia and other health problems for both children and their relatives. The availability of molecular/genetic screening tests has increased early diagnosis of younger members of known polyposis families. This article reviews the gross and microscopic features of polyposis syndromes of childhood and summarizes the molecular/genetic advances in this field. Clinical management is also briefly discussed.
Lowichik
Amy
A
Department of Pathology, University of Utah Health Sciences Center, 30 N. 1900 E, Salt Lake City, UT 84132-2501, USA. pcalowic@ihc.com
Jackson
W Daniel
WD
Coffin
Cheryl M
CM
D011125:Adenomatous Polyposis Coli / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D003111:Colonic Polyps / Q000235:genetics / Q000473:pathology; D015179:Colorectal Neoplasms / Q000235:genetics / Q000473:pathology; D017491:Genes, APC; D006801:Humans; D007223:Infant; D009154:Mutation; D010580:Peutz-Jeghers Syndrome / Q000235:genetics / Q000473:pathology; D013577:Syndrome