Neurohormone activation.
Neurohormonal activation plays a significant role in left ventricular remodeling and progression of heart failure. Treatment strategies that antagonize the RAS and sympathetic nervous system can attenuate the left ventricular remodeling process. Natriuretic peptides, specifically BNP, are a marker of left ventricular dysfunction. With the progressive increase in the incidence and prevalence of heart failure, treatment approaches must focus on the underlying cause as well as on blocking the neurohormonal activation that leads to the remodeling process.
Piano
Mariann R
MR
Department of Medical-Surgical Nursing, University of Illinois at Chicago College of Nursing, 845 South Damen Street, Chicago, IL 60612, USA. Piano@uic.edu
Prasun
Marilyn
M
D000450:Aldosterone / Q000502:physiology; D018450:Disease Progression; D006333:Heart Failure / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D045265:Natriuretic Peptides / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology; D014667:Vasopressins / Q000502:physiology; D020257:Ventricular Remodeling / Q000502:physiology
D045265:Natriuretic Peptides; D018377:Neurotransmitter Agents; D014667:Vasopressins; D000450:Aldosterone; D009638:Norepinephrine