A nosocomial outbreak of Serratia marcescens producing inducible Amp C-type beta-lactamase enzyme and carrying antimicrobial resistance genes within a class 1 integron.
We investigated an outbreak of Serratia marcescens in the adult intensive care unit of the University Hospital of Napoli. The outbreak involved 13 cases of infection by S. marcescens over a nine-month period and was caused by a single pulsed-field gel electrophoresis clone. The epidemic strain was multiply antibiotic resistant, producing an inducible Amp C-type beta-lactamase enzyme and carrying the trimethoprim-resistance gene and the adenyltransferase gene, which confers resistance to streptomycin and spectinomycin, within a class 1 integron. Antimicrobial therapy with beta-lactams was associated with S. marcescens acquisition in the intensive care unit.
Bagattini
M
M
Dipartimento di Scienze Mediche Preventive, Università Federico II, Napoli, Italy.
Crispino
M
M
Gentile
F
F
Barretta
E
E
Schiavone
D
D
Boccia
M C
MC
Triassi
M
M
Zarrilli
R
R
D000328:Adult; D001426:Bacterial Proteins; D002999:Clone Cells; D003428:Cross Infection / Q000453:epidemiology* / Q000235:genetics / Q000382:microbiology; D004196:Disease Outbreaks; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D005260:Female; D006785:Hospitals, University; D006801:Humans; D032023:Integrons / Q000235:genetics; D007362:Intensive Care Units; D007558:Italy / Q000453:epidemiology; D008297:Male; D016868:Serratia Infections / Q000453:epidemiology* / Q000235:genetics / Q000382:microbiology; D012706:Serratia marcescens / Q000201:enzymology / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
D001426:Bacterial Proteins; C048795:AmpC beta-lactamases; D001618:beta-Lactamases