VE-DIC light microscopy and the discovery of kinesin.
Major advances in science are often tightly coupled with the development of new technology. The discovery of kinesin is an excellent example of this principle. The new technology was video-enhanced differential interference contrast light microscopy, which provided the enormous gain in image contrast needed to detect and measure kinesin-based motility in living cells, cell extracts and in vitro motility assays.
Salmon
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Dept of Biology, University of North Carolina, Chapel Hill, NC 27599-3280, USA.