A new synthesis of lysergic acid.
[reaction: see text] (+/-)-Lysergic acid has been synthesized via an economical 8-step route from 4-bromoindole and isocinchomeronic acid without the need to protect the indole during the synthesis. Initial efforts to form the simpler 3-acylindole derivatives first and then cyclize these were unsuccessful in the cyclization step.
Hendrickson
James B
JB
Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, USA. hendrickson@brandeis.edu
Wang
Jian
J