[Clinical study on effect of jiexiao oral liquid in preventing and curing virus induced asthma in children].
OBJECTIVE
To observe the effect and the possible mechanism of Jiexiao Oral Liquid (JXOL) in preventing and curing virus induced asthma in children.


METHODS
One hundred and sixty patients of acute upper respiratory tract infection (AURTI) with asthma history were randomly divided into 2 groups. JXOL was given to the treated group within 24 hrs after occurrence of AURTI symptoms, and virazole of 10-15 mg.kg-1.d-1 was given to the control group, the therapeutic course for both groups was 7 days. Changes of clinical symptoms, signs, therapeutic effect, pulmonary function and immuno-globulin in patients were observed.


RESULTS
The total effective rate of the treated group was 83.8%, the clinical control rate was 48.8%, while those in the control group were 62.5% and 23.8% respectively, showing significant difference between them (P < 0.01). JXOL could obviously improve the indexes of forced expiratory volume in one second (FEV1) and peak expiratory flow (PEF), reduce the level of IgE, as compared with those before treatment, the difference was significant (P < 0.01 or P < 0.05); it also showed significant difference as compared with those in the control group after treatment. The changes of IgA, IgG and IgM after treatment showed insignificant difference.


CONCLUSIONS
JXOL was effective in preventing and curing virus induced asthma in children, it also shows pulmonary function improving and immune regulating effects.
Wang
Meng-qing
MQ
Department of Pediatrics, First Affiliated Hospital, Hunan TCM College, Changsha 410007. wmqwmq@sina.com
Zhu
Ye
Y
Shu
Lan
L
D000293:Adolescent; D001249:Asthma / Q000188:drug therapy* / Q000517:prevention & control / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008517:Phytotherapy; D012141:Respiratory Tract Infections / Q000150:complications / Q000821:virology
D004365:Drugs, Chinese Herbal; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007073:Immunoglobulin E