[Interleukin-18 and its related cytokines in plasma of patients with idiopathic thrombocytopenic purpura].
To explore the role of immune regulating cytokines in pathogenesis of the idiopathic thrombocytopenic purpura (ITP) and its clinical significance, the levels of IL-18, TNF-alpha and Sc5b-9 in plasma of 32 ITP patients and 18 normal individuals were detected using ELISA methods. The results showed that IL-18, TNF-alpha and sC5b-9 levels in plasma of ITP patients were higher than that in normal individuals. The level of IL-18 was positively correlated with the levels of TNF-alpha and sC5b-9. In conclusion, The rising levels of the IL-18, TNF-alpha and sC5b-9 were correlated with disorder of Th1/Th2 subsets, and may contribute to the immune dysfunction in ITP patients. The dynamic observation of these cytokines may be useful in directing the clinical treatment for ITP patients.
Zhang
Lu-Qin
LQ
Department of Hematology, The First People's Hospital of Xuzhou, Xuzhou 221002, China.
Ge
Jin-Yuan
JY
Guo
Yu-Lin
YL
Zhao
Hui-Ren
HR
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015938:Complement Membrane Attack Complex / Q000032:analysis*; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D015938:Complement Membrane Attack Complex; D020382:Interleukin-18; D014409:Tumor Necrosis Factor-alpha