title: Development of a canine model for recurrent respiratory papillomatosis.
abstract: A canine model for recurrent respiratory papillomatosis (RRP) was developed with canine oral papillomavirus (COPV) inoculated into the buccal mucosa and supraglottic larynx of 5 beagles. The animals received systemic immunosuppression with daily oral prednisone at doses of 0, 1, 2, 3, and 4 mg/kg. Buccal papillomata developed at 6 weeks in all animals and regressed by 10 weeks in the animals that received 0 and 1 mg/kg. The other animals had continuous growth of their buccal papillomata for 26 weeks. The animal that received 2 mg/kg developed papillomata on the lingual surface of the epiglottis that continued to grow through 26 weeks. Systemic oral prednisone successfully maintained COPV-induced oral and laryngeal papillomata in beagles. Thus, COPV-induced oral and laryngeal papillomata that are prednisone-maintained may have utility as a model for RRP.
authors.affiliation: Division of Head and Neck Surgery, Department of Surgery, University of California-Los Angeles School of Medicine, Los Angeles, California 90095, USA.
authors.forename: Babak
authors.initials: B
authors.lastname: Jahan-Parwar
authors.forename: Dinesh K
authors.initials: DK
authors.lastname: Chhetri
authors.forename: Steven
authors.initials: S
authors.lastname: Hart
authors.forename: Sunita
authors.initials: S
authors.lastname: Bhuta
authors.forename: Gerald S
authors.initials: GS
authors.lastname: Berke
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs / Q000821:virology; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000821:virology; D009062:Mouth Neoplasms / Q000473:pathology / Q000821:virology; D009364:Neoplasm Recurrence, Local; D010212:Papilloma / Q000473:pathology / Q000821:virology; D027383:Papillomaviridae
chemical_list: D007166:Immunosuppressive Agents