Immunity in Caenorhabditis elegans.
Until very recently it was not known whether the invertebrate Caenorhabditis elegans was capable of mounting a specific immune response to protect itself from pathogens. It has only just become clear that this simple nematode in fact possesses a complex innate immune system, involving multiple signalling pathways and an armoury of antimicrobial proteins and peptides. Genetic and microarray approaches are now revealing the molecular cross-talk that exists between the different signalling cascades.
Millet
Anne C M
AC
Institut National de la Sante et de la Recherche Medicale/Centre National pour la Recherche Scientifique /Université de la Méditerranée, 13288 Cedex 9 Marseille, France.
Ewbank
Jonathan J
JJ
D000818:Animals; D017173:Caenorhabditis elegans / Q000276:immunology*; D029742:Caenorhabditis elegans Proteins; D007107:Immune System / Q000276:immunology; D007113:Immunity, Innate; D020929:Mitogen-Activated Protein Kinase Kinases / Q000502:physiology; D011972:Receptor, Insulin / Q000502:physiology; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000502:physiology
D029742:Caenorhabditis elegans Proteins; D016212:Transforming Growth Factor beta; C107483:DAF-2 protein, C elegans; D011972:Receptor, Insulin; D020929:Mitogen-Activated Protein Kinase Kinases