Betamethasone associated changes in umbilical artery flow velocity waveforms in multiple pregnancies with umbilical artery absent end diastolic flow.
OBJECTIVE
It has been previously shown that glucocorticoids alter umbilical artery flow velocity waveforms in singleton pregnancies complicated by umbilical artery absent end diastolic flow. Whether similar effects are evident in multiple pregnancies where one fetus has umbilical artery absent end diastolic flow is not known.


METHODS
Women with a twin or triplet pregnancy complicated by umbilical artery absent end diastolic flow in one fetus were admitted to hospital for intensive fetal surveillance including daily umbilical artery flow velocity waveform studies, as per hospital protocol. All women received prophylactic betamethasone (11.4 mg x 2, 24 h apart) in anticipation of preterm delivery.


RESULTS
Between October 1996 and February 2002, 24 women with a multiple pregnancy complicated by umbilical artery absent end diastolic flow were cared for. Of these, six had a pregnancy with feto-fetal transfusion and excluded from further analysis. Of the remaining 18 women, eight had monochorionic diamniotic twins, eight had dichorionic twins, and two had trichorionic, triamniotic triplets. The median (range) gestation at diagnosis of umbilical artery absent end diastolic flow was 210.5 days (173-241). In nine (50%) of the 18 pregnancies the administration of betamethasone was associated with return of umbilical artery end diastolic flow for a median of 5 days. There was no association between this effect and chorionicity. The median (range) interval from diagnosis of umbilical artery absent end diastolic flow to delivery was 11 days (1-46).


CONCLUSIONS
As previously reported in singleton pregnancies, the maternal administration of betamethasone in multiple pregnancies with umbilical artery absent end diastolic flow is associated with a transient return of end diastolic flow.
Barkehall-Thomas
Andrea
A
Maternal-Fetal Medicine Unit, Monash Medical Centre, Southern Health, Clayton, Victoria, Australia. a.barkehallthomas@southernhealth.org.au
Thompson
Melanie
M
Baker
Lesleigh S
LS
Edwards
Andrew
A
Wallace
Euan M
EM
D001623:Betamethasone / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects* / Q000502:physiology; D003971:Diastole / Q000502:physiology; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D011247:Pregnancy; D011272:Pregnancy, Multiple / Q000187:drug effects / Q000502:physiology*; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D014310:Triplets; D014427:Twins; D016216:Ultrasonography, Prenatal / Q000187:drug effects*; D014469:Umbilical Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology*
D005938:Glucocorticoids; D001623:Betamethasone