Development of a canine model for recurrent respiratory papillomatosis.
A canine model for recurrent respiratory papillomatosis (RRP) was developed with canine oral papillomavirus (COPV) inoculated into the buccal mucosa and supraglottic larynx of 5 beagles. The animals received systemic immunosuppression with daily oral prednisone at doses of 0, 1, 2, 3, and 4 mg/kg. Buccal papillomata developed at 6 weeks in all animals and regressed by 10 weeks in the animals that received 0 and 1 mg/kg. The other animals had continuous growth of their buccal papillomata for 26 weeks. The animal that received 2 mg/kg developed papillomata on the lingual surface of the epiglottis that continued to grow through 26 weeks. Systemic oral prednisone successfully maintained COPV-induced oral and laryngeal papillomata in beagles. Thus, COPV-induced oral and laryngeal papillomata that are prednisone-maintained may have utility as a model for RRP.
Jahan-Parwar
Babak
B
Division of Head and Neck Surgery, Department of Surgery, University of California-Los Angeles School of Medicine, Los Angeles, California 90095, USA.
Chhetri
Dinesh K
DK
Hart
Steven
S
Bhuta
Sunita
S
Berke
Gerald S
GS
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs / Q000821:virology; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000821:virology; D009062:Mouth Neoplasms / Q000473:pathology / Q000821:virology; D009364:Neoplasm Recurrence, Local; D010212:Papilloma / Q000473:pathology / Q000821:virology; D027383:Papillomaviridae
D007166:Immunosuppressive Agents