[Prevalence of serologic markers in celiac disease in trisomy 21 in Tunisia].
OBJECTIVE
This study was aimed to investigate the prevalence of serologic markers of celiac disease in Tunisian patients with trisomy 21.


METHODS
Twenty seven patients with trisomy 21 were prospectively screened by indirect immunofluorescence for anti-reticulin and anti-endomysium antibodies, and by an ELISA method for anti-gliadin and anti-transglutaminase antibodies. None of the 27 patients had known celiac disease at the time of the study.


RESULTS
Anti-reticulin, anti-endomysium, anti-gliadin and anti-transglutaminase antibodies were found in respectively 11%, 11%, 18.5%, and 14.8% of cases. Only one patient with all serologic markers of celiac disease underwent biopsy which shows a villous atrophy.


CONCLUSIONS
Anti-endomysium and anti-transglutaminase antibodies are good immunologic markers for the screening for celiac disease, a screening which is justified in patient with trisomy 21.
Zitouni
M
M
Laboratoire d'immunologie, Hôpital La Rabta, Tunis, Tunisie.
Gharbi Yermani
M
M
Laadhar Kharrat
L
L
Kallel Sellami
M
M
Gandoura
N
N
Makni
S
S
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002446:Celiac Disease / Q000097:blood* / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000097:blood* / Q000150:complications*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D007223:Infant; D008297:Male; D011446:Prospective Studies; D016036:Seroepidemiologic Studies; D014416:Tunisia
D015415:Biomarkers; D007136:Immunoglobulins