[The expression of peripheral blood neutrophil CD64 in systemic lupus erythematosus with infection or disease activation].
OBJECTIVE
To explore the significance of expression of peripheral blood neutrophil CD(64) to distinguish infection from disease activation in systemic lupus erythematosus (SLE).


METHODS
19 patients with infection and 46 patients with non-infection in 65 SLE patients were studied. The levels of peripheral blood neutrophil CD(64) were measured by flow cytometry.


RESULTS
The levels of peripheral blood neutrophil CD(64) in SLE infection patients were [(7.8 +/- 2.1)%], which were significantly higher than that of non-infection group [(3.2 +/- 1.4)%] and healthy control [(3.0 +/- 1.1)%, P > 0.05]. However, there were no significance between the levels of non-infection group and healthy control (P > 0.05). There were no significance between the levels of CD(64) of disease activation and silence group and non-infection group (P > 0.05). In SLE infection group, the levels of CD(64) expression in patients with Gram-negative [(9.2 +/- 1.6)%] were compared with [(7.2 +/- 2.2)%] those with Gram-positive. The differences were not significant (P > 0.05). The levels of CD(64) of SLE patients with infection were decreased by treatment with antibiotics. The correlation of the levels of CD(64) with anti-dsDNA, C(3), ESR, CRP, SLE-disease activity index and IFANA were not found (respectively r = 0.104, P = 0.409; r = -0.125, P = 0.322; r = -0.138, P = 0.274; r = 0.228, P = 0.068; r = 0.204, P = 0.310; r = -0.213, P = 0.089).


CONCLUSIONS
The levels of peripheral blood neutrophil CD(64) may help us distinguish infection from disease activation in SLE.
Yang
Xu-yan
XY
Department of Internal Medicine, the First Affiliated Hospital of Zhejiang University, Hangzhou 310003, China. hangzhouyxy@hotmail.com
Lin
Jin
J
Li
You-ming
YM
D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000097:blood* / Q000276:immunology; D002648:Child; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D017452:Receptors, IgG / Q000097:blood*; D013997:Time Factors
D017452:Receptors, IgG