Efficient synthesis of polysubstituted acylguanidines and guanylureas.
(Benzotriazol-1-yl)carboximidamides were applied for the preparation of polysubstituted acylguanidines and guanylureas. The reaction sequence utilized mild conditions and gave high yields for final compounds and intermediates. The protocol developed allows for variation of the substituents at all positions of the products.
Katritzky
Alan R
AR
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA. katritzky@chem.ufl.edu
Rogovoy
Boris V
BV
Cai
Xiaohong
X
Kirichenko
Nataliya
N
Kovalenko
Katherine V
KV