Fluoroquinolone resistance linked to GyrA, GyrB, and ParC mutations in Salmonella enterica typhimurium isolates in humans.
We report two cases of infection with clonally unrelated, high-level ciprofloxacin-resistant, b-lactamase-producing strains of Salmonella enterica Typhimurium. Resistance was caused by four topoisomerase mutations, in GyrA, GyrB, and ParC and increased drug efflux. Ciprofloxacin treatment failed in one case. In the second case, reduced susceptibility to third-generation cephalosporins occurred after initial treatment with these drugs and may explain the treatment failure with ceftriaxone.
Casin
Isabelle
I
Hõpital Saint-Louis, Université Paris VII, Paris, France.
Breuil
Jacques
J
Darchis
Jean Pierre
JP
Guelpa
Claire
C
Collatz
Ekkehard
E
D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002939:Ciprofloxacin / Q000627:therapeutic use*; D027081:DNA Gyrase / Q000187:drug effects / Q000235:genetics*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D024841:Fluoroquinolones / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D012480:Salmonella Infections / Q000188:drug therapy*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D002939:Ciprofloxacin; D027081:DNA Gyrase