Decrease of beta-cells and increase of alpha-cells in a diabetic patient with mitochondrial DNA 3243 (A-->G) mutation.
We report here a case of a 53-year-old woman with mitochondrial 3243 (A-->G) mutation diabetes. Diabetes mellitus was diagnosed at 39 years of age. At 50 years of age, cardiomyopathy and hypothyroidism were noted. At 53 years of age, the patient was admitted to our hospital for treatment of necrotic ulceration of toes. However, she died of massive heart failure. Pathological examination at autopsy showed a decrease in size, number, and acidophilicity of islets in the pancreas. Immunohistochemical stain revealed a decrease in the beta-cell population to 20.5+/-9.2% and a relative increase in alpha-cell population to 48.6+/-11.5%.
Kojima
Toshihiro
T
Department of Internal Medicine, Gifu Central Hospital, Gifu.
Yamamoto
Mayumi
M
Furuhashi
Naoki
N
Sarui
Hiroshi
H
Takatsu
Hisato
H
Takeda
Noriyuki
N
Ishizuka
Tatsuo
T
Yamada
Koji
K
Yasuda
Keigo
K
D002311:Cardiomyopathy, Dilated / Q000235:genetics; D004272:DNA, Mitochondrial / Q000235:genetics*; D003638:Deafness / Q000235:genetics; D003920:Diabetes Mellitus / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000235:genetics; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000378:metabolism*; D008875:Middle Aged; D017354:Point Mutation; D012356:RNA, Transfer, Leu / Q000235:genetics
D004272:DNA, Mitochondrial; D012356:RNA, Transfer, Leu