Recognition of infected cells by natural killer cells.
Under the influence of cytokines associated with innate immunity, natural killer (NK) cells rapidly become activated and migrate to sites of infection. Upon contact with infected parenchyma they proliferate, release cytokines and/or kill cells harboring pathogens. Multiple stimulatory and inhibitory receptors can provide the integrated signals that trigger this contact-mediated NK-cell function. Recent work has begun to define the ligands for these receptors in the context of infection by certain well-studied viruses. These results, in addition to future work involving other pathogens, will provide an understanding of the molecules present on parasitized cells that mark them as targets of innate immunity.
Carayannopoulos
Leonidas N
LN
Howard Hughes Medical Institute, Division of Pulmonary and Critical Care Medicine, Washington University Medical Center, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
Yokoyama
Wayne M
WM
D003602:Cytotoxicity, Immunologic; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008024:Ligands; D008213:Lymphocyte Activation; D018146:Muromegalovirus / Q000502:physiology; D055627:Natural Cytotoxicity Triggering Receptor 1; D018121:Receptors, Cytokine / Q000378:metabolism; D011971:Receptors, Immunologic / Q000378:metabolism* / Q000502:physiology; D055607:Receptors, Natural Killer Cell; D015398:Signal Transduction / Q000276:immunology
D008024:Ligands; C112260:NCR1 protein, human; D055627:Natural Cytotoxicity Triggering Receptor 1; D018121:Receptors, Cytokine; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell