Bioartificial pancreas research in Japan.
The bioartificial pancreas (BAP), a medical device enclosing insulin-secreting cells in a semipermeable membrane, is expected to physiologically control glucose levels, and thus to be able to inhibit development of serious chronic complications in diabetic patients. In this brief review, we introduce research activities on the development of the BAP in Japan, including membrane preparation for the BAP, evaluation of in vitro and in vivo BAP functions, and challenges for production of insulin-secreting cells from stem cells.
Iwata
Hiroo
H
Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan. iwata@frontier.kyoto-u.ac.jp
Simada
Hideki
H
Fukuma
Eisai
E
Ibii
Takahisa
T
Sato
Hideki
H
D000818:Animals; D002454:Cell Differentiation; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy*; D004622:Embryo, Mammalian / Q000166:cytology; D004867:Equipment Design; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D016381:Islets of Langerhans Transplantation; D007564:Japan; D051379:Mice; D019397:Pancreas, Artificial; D013234:Stem Cells / Q000166:cytology
D007328:Insulin