title: Factors associated with long-term progression or stability in exfoliation glaucoma.
abstract: OBJECTIVE
  To evaluate the effect of intraocular pressure (IOP) reduction on long-term progression or stability in patients with exfoliation glaucoma.
  
  
  METHODS
  Multicenter (Greece, Spain, Russia, and Hungary), retrospective analysis.
  
  
  METHODS
  Medical record analysis of 167 patients with at least 5 years of follow-up, who were stable (n = 85) or whose condition had progressed (n = 82) after the beginning of the follow-up period.
  
  
  RESULTS
  The mean +/- SD IOP was 18.1 +/- 2.6 mm Hg in the stable group and 20.1 +/- 4.3 mm Hg in the progressed group (P<.001). The mean +/- SD follow-up time was 6.1 +/- 2.3 years for the stable group and 3.4 +/- 1.7 years for the progressed group. The mean SD for each patient's average IOP was 2.9 mm Hg for the stable group and 4.6 mm Hg for the progressed group (P<.001). Twenty-eight percent of patients who had a mean IOP of 17 mm Hg or lower, 43% of those with an IOP of 18 to 19 mm Hg, and 70% of those with an IOP of 20 mm Hg or higher progressed. Progressed patients had statistically greater optic disc damage at baseline and more medication changes and trabeculectomies during follow-up than stable patients (P<.05).
  
  
  CONCLUSIONS
  This study suggests that IOP reduction helps to prevent glaucoma progression in patients with exfoliation glaucoma, although it does not guarantee the prevention or worsening of the disease.
authors.affiliation: University Department of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece.
authors.forename: Anastasios G P
authors.initials: AG
authors.lastname: Konstas
authors.forename: Gabor
authors.initials: G
authors.lastname: Hollo
authors.forename: Yuri S
authors.initials: YS
authors.lastname: Astakhov
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Teus
authors.forename: Evgeny L
authors.initials: EL
authors.lastname: Akopov
authors.forename: Jessica N
authors.initials: JN
authors.lastname: Jenkins
authors.forename: William C
authors.initials: WC
authors.lastname: Stewart
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D018450:Disease Progression; D017889:Exfoliation Syndrome / Q000503:physiopathology* / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D005901:Glaucoma / Q000503:physiopathology* / Q000517:prevention & control; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D009898:Optic Disk / Q000503:physiopathology; D009901:Optic Nerve Diseases / Q000503:physiopathology; D012189:Retrospective Studies; D012307:Risk Factors; D014130:Trabeculectomy; D014792:Visual Acuity
chemical_list: D000959:Antihypertensive Agents