Prevention of thrombus formation with glyprolines on various models of prethrombotic state and thrombosis in rats.
Peroral administration of peptide Pro-Gly-Pro to 10-11-month-old rats with modeled prethrombotic state normalized functions of the anticoagulation system and produced a potent antiplatelet effect. Peroral administration of Pro-Gly peptide before provocation of thrombin generation and thrombus formation prevented death of animals from thrombosis. Experiments on rats with venous thrombosis induced by stasis and administration of thrombin showed that pretreatment with Pro-Gly peptide decreased the weight of formed thrombi.
Pastorova
V E
VE
Department of Human and Animal Physiology, Biological Faculty, M V Lomonosov Moscow State University.
Lyapina
L A
LA
Ashmarin
I P
IP
D000284:Administration, Oral; D000818:Animals; D021461:Animals, Outbred Strains; D000925:Anticoagulants / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects; D004195:Disease Models, Animal; D005342:Fibrinolysis; D006490:Hemostatics / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D009842:Oligopeptides / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D051381:Rats; D015996:Survival Rate; D013924:Thrombophlebitis / Q000097:blood / Q000188:drug therapy / Q000473:pathology; D013925:Thromboplastin / Q000494:pharmacology; D013927:Thrombosis / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000517:prevention & control; D013997:Time Factors
D000925:Anticoagulants; D006490:Hemostatics; D009842:Oligopeptides; D010975:Platelet Aggregation Inhibitors; D013925:Thromboplastin