title: Study of the development of thermoresistance in human pancreatic carcinoma cell lines using proteome analysis.
abstract: In order to find candidate proteins that are potentially associated with the thermoresistant phenotype in combination with drug resistance, we analyzed the differential protein expression in vitro in the human pancreatic cancer cell line EPP85-181-P and classical and atypical multidrug-resistant variants and their thermoresistant counterparts using proteomics. This study identifies sets of proteins that may lead to the development of thermoresistance. These results provide a fundamental basis to elucidate the molecular mechanism of thermoresistance and chemoresistance phenomena that may assist the therapy of inoperable cancers.
authors.affiliation: Institut für Laboratoriumsmedizin und Pathobiochemie, Universitätsklinikum Charité, Berlin, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Poland
authors.forename: Andrea
authors.initials: A
authors.lastname: Urbani
authors.forename: Hermann
authors.initials: H
authors.lastname: Lage
authors.forename: Martina
authors.initials: M
authors.lastname: Schnölzer
authors.forename: Pranav
authors.initials: P
authors.lastname: Sinha
mesh_terms: D000220:Adaptation, Biological; D045744:Cell Line, Tumor; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D009363:Neoplasm Proteins / Q000032:analysis / Q000302:isolation & purification* / Q000502:physiology*; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000503:physiopathology; D010641:Phenotype; D040901:Proteomics / Q000379:methods*; D013696:Temperature
chemical_list: D009363:Neoplasm Proteins