Signaling endosome hypothesis: A cellular mechanism for long distance communication.
The kinetics of signaling endosome retrograde transport along axons is analyzed and offered as evidence that such transport is more efficient than diffusion or calcium wave-based signaling systems over even relatively small distances. Evidence is provided to support the signaling endosome hypothesis and to expand the hypothesis to include signaling in many cell types and many cellular dimensions. Finally, a saltatory, regenerating inositol 1,4,5-trisphosphate wave model is offered to reconcile current discrepancies in the literature regarding endosomal-based retrograde signaling.
Howe
Charles L
CL
Mechanisms of Neural Repair Lab, Department of Neurology, Mayo Medical and Graduate Schools, Guggenheim 442C, 200 First Street SW, Rochester, Minnesota 55905, USA. howe.charles@mayo.edu
Mobley
William C
WC
D000818:Animals; D001370:Axonal Transport / Q000502:physiology; D002450:Cell Communication / Q000502:physiology*; D011992:Endosomes / Q000502:physiology*; D007700:Kinetics; D008954:Models, Biological; D020932:Nerve Growth Factor / Q000378:metabolism
D020932:Nerve Growth Factor