title: Quality of life among disease-free survivors of rectal cancer.
abstract: OBJECTIVE
  To identify factors affecting the quality of life (QoL) of disease-free survivors of rectal cancer.
  
  
  METHODS
  One hundred twenty-one patients in complete remission more than 2 years after diagnosis were asked to complete three QoL questionnaires: the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30; its colorectal module, QLQ-CR38; and the Duke generic instrument.
  
  
  RESULTS
  Patients reported less pain (P =.002) than did controls drawn from the general population. EORTC QLQ-C30 physical scores were also higher among rectal cancer survivors than in the general Norwegian or German population (P =.0005 and P =.002, respectively). Unexpectedly, stoma patients reported better social functioning than did nonstoma patients (P =.005), with less anxiety (P =.008) and higher self-esteem (P =.0002). In the present authors' experience, the QLQ-CR38 does not discriminate between these groups. Residual abdominal or pelvic pain and constipation had the most negative influence on QoL.
  
  
  CONCLUSIONS
  QoL is high among rectal cancer survivors, including stoma patients. Simultaneous use of several QoL questionnaires appears to have value in follow-up and in monitoring the effects of therapy. The impact of residual pain and constipation on long-term QoL should be considered when establishing a treatment regimen.
authors.affiliation: Surgical Department and Medical Oncology, Centre Alexis Vautrin, 54511 Vandoeuvre lès Nancy, France. p.rauch@nancy.fnclcc.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Rauch
authors.forename: Joelle
authors.initials: J
authors.lastname: Miny
authors.forename: Thierry
authors.initials: T
authors.lastname: Conroy
authors.forename: Lionel
authors.initials: L
authors.lastname: Neyton
authors.forename: Francis
authors.initials: F
authors.lastname: Guillemin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003248:Constipation; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain; D011788:Quality of Life; D012004:Rectal Neoplasms / Q000473:pathology* / Q000523:psychology*; D012649:Self Concept; D012934:Social Isolation; D017741:Survivors