Nuclear pre-mRNA metabolism: channels and tracks.
We review new evidence suggesting that metazoan nuclear pre-mRNA metabolism occurs in a small subnuclear compartment consisting of a network of channels defined by exclusion from various condensed structures. Nuclear components, including mRNA en route from the gene to the nuclear surface, apparently move through these channels by conventional diffusion.
Kramer
J
J
Department of Biochemistry and Cell Biology, University of New York, Stony Brook, NY 11794, USA.
Zachar
Z
Z
Bingham
P M
PM