[Efficacy of gamma knife radiosurgery in treatment of growth hormone-secreting pituitary adenoma].
OBJECTIVE
To evaluate the efficacy of gamma knife radiosurgery (GKS) in treatment of growth hormone (GH)-secreting pituitary adenoma.


METHODS
149 patients with GH-secreting pituitary adenoma, 97 males and 52 females, aged 42.8 (12-72 years), with a course of 6-240 months (72.5 months) and with the mean volume of tumor of 2.36 cm(3) (0.11-12.7 cm(3)) were treated by GKS. The mean dose to tumor margin was 20.87 Gy (10-30 Gy). 124 of them were followed up for 30 months (6-72 months).


RESULTS
The serum GH returned normal in 74 patients (64.9%) and declined in comparison with the level before radiosurgery in 23 patients (18.5%). The tumor volume was reduced in 84 patients (67.7%) and remained unchanged in 124 patients (32.4%). Ambiopia appeared in one patient. No other complication was found during the follow-up.


CONCLUSIONS
GKS is safe and effective on the treatment of GH-secreting pituitary adenoma.
Wang
Mei-hua
MH
Gamma Knife Center, Beijing Neurosurgical Institute, Beijing 100050, China.
Liu
Peng
P
Liu
A-li
AL
Luo
Bin
B
Sun
Shi-bin
SB
D000236:Adenoma / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D019382:Human Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000601:surgery*; D016634:Radiosurgery / Q000009:adverse effects
D019382:Human Growth Hormone