Association between the tumor necrosis factor-alpha -308 G/A gene polymorphism and migraine.
In a group of 299 migraine patients and 306 control subjects, the association of the -308 G/A polymorphism in the tumor necrosis factor-alpha gene (TNFalpha) with the occurrence and clinical characteristics of migraine was tested. Homozygosity for the G allele was associated with an increased risk of migraine (odds ratio [OR] = 2.85, p < 0.001). When the patients were divided into subgroups, the association was confirmed in patients affected by migraine without aura (OR = 3.30, p < 0.001) but not in migraine with aura. These data suggest that the TNFalpha gene or a linked locus significantly modulates the risk for migraine.
Rainero
I
I
Neurology III Headache Center, Department of Neuroscience, University of Torino, Italy. irainero@molinette.piemonte.it
Grimaldi
L M E
LM
Salani
G
G
Valfrè
W
W
Rivoiro
C
C
Savi
L
L
Pinessi
L
L
D000328:Adult; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006720:Homozygote; D006801:Humans; D007558:Italy; D008297:Male; D008881:Migraine Disorders / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012016:Reference Values; D018570:Risk Assessment; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha