TRAIL, Bim, and thymic-negative selection.
Negative selection is a process whereby autoreactive lymphocytes are deleted through apoptosis. Negative selection is essential for self-tolerance and its breakdown may lead to the development of autoimmune diseases. Although the phenomenon of negative selection is well-recognized, its underlying molecular mechanisms are unclear. Recent studies using gene-knockout mice have provided new insights into the mechanisms of negative selection. In this review, we discuss the newly discovered roles of TRAIL and Bim in negative selection. Our main focus will be on T cells and T cell mediated autoimmune diseases.
Zheng
Shi-Jun
SJ
Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA.
Chen
Youhai H
YH
D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D000072224:Bcl-2-Like Protein 11; D002352:Carrier Proteins / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology*; D008565:Membrane Proteins; D051379:Mice; D018448:Models, Immunological; D011518:Proto-Oncogene Proteins; D017634:Self Tolerance; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D053221:TNF-Related Apoptosis-Inducing Ligand; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
D051017:Apoptosis Regulatory Proteins; D000072224:Bcl-2-Like Protein 11; C000606776:Bcl2l11 protein, mouse; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011518:Proto-Oncogene Proteins; D053221:TNF-Related Apoptosis-Inducing Ligand; C505654:Tnfsf10 protein, mouse; D014409:Tumor Necrosis Factor-alpha