Pregnancy in a breast cancer patient treated with a LHRH analogue at ablative doses.
A 36-year-old female diagnosed of breast cancer was treated with surgery, chemotherapy, radiotherapy and goserelin. After 17 months of uninterrupted therapy with this LHRH analogue at hormone suppressive doses, a 16-week gestation foetus was detected and the treatment was withdrawn. Although the drug was administered throughout the first 4 months of pregnancy it resulted in the term delivery of a healthy infant, and no foetal adverse effects were detected. A review of the influence of hormonal treatment for breast cancer on fertility and birth defects has been performed.
Jiménez-Gordo
A M
AM
Medical Oncology Department, Hospital Universitario La Paz, Paseo de la Castellana, number 261, 28046 Madrid, Spain.
Espinosa
E
E
Zamora
P
P
Feliu
J
J
Rodríguez-Salas
N
N
González-Barón
M
M