title: Plasma homocysteine levels in patients with early coronary artery stenosis and high risk factors.
abstract: The aim of this study was to study the relationship between plasma homocysteine (Hcy), folic acid, vitamin B12 and early coronary artery disease (early-CAD) and high coronary risk factors. The plasma Hcy levels of 58 cases with early-CAD and 31 subjects without CAD were measured using high-performance liquid chromatography (HPLC) with fluorescence detection. Plasma folic acid and Vitamin B12 levels were measured with radioassay method. The plasma Hcy level was significantly higher in the early-CAD patients than in the controls [(13.7 +/- 5.1) micromol/L vs (10.3 +/- 5.7) micromol/L]. The plasma folic acid and Vitamin B12 levels were significantly lower in the early-CAD patients than in the controls. The plasma Hcy level was higher in patients with more than 3 risk factors of CAD than in patients with 1 or 2 risk factors and in the controls [(17.3 +/- 5.1) micromol/ L vs (12.9 +/- 4.8) micromol/L, (7.8 +/- 2.5) micromol/L]. Other than gender, all classical coronary risk factors were related to the elevated Hcy level. Hcy levels were elevated in patients with early-CAD and with high risk factors. Hyperhomocysteinemia plays an important role in the pathogenesis of CAD.
authors.affiliation: Department of Cardiology, Medical College, Zhejiang University, Hangzhou, China.
authors.forename: Hangyuan
authors.initials: H
authors.lastname: Guo
authors.forename: Jong-Dae
authors.initials: JD
authors.lastname: Lee
authors.forename: Takanori
authors.initials: T
authors.lastname: Ueda
authors.forename: Jiang
authors.initials: J
authors.lastname: Shan
authors.forename: Jian'an
authors.initials: J
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D023921:Coronary Stenosis / Q000097:blood* / Q000209:etiology*; D048909:Diabetes Complications; D005492:Folic Acid / Q000097:blood*; D006710:Homocysteine / Q000097:blood* / Q000502:physiology; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking; D014805:Vitamin B 12 / Q000097:blood*
chemical_list: D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12