The effects of citicoline and lamotrigine alone and in combination following permanent middle cerebral artery occlusion in rats.
The neuroprotective efficacies of citicoline and lamotrigine, alone and in combination, were investigated in experimental permanent focal ischemia. Seven groups of adult male rats underwent focal cerebral ischemia and were given the following treatments: placebo (P), low and high doses of citicoline (C250 and C500, 250 and 500 mg/kg/day i.p., respectively), low and high doses of lamotrigine (L50 and L100, 50 and 100 mg/kg/day p.o., respectively), and combination regimes of both drugs in low (C250 + L50) and high doses (C500 + L100). Citicoline, but not lamotrigine, exerted neuroprotective efficacy during this acute ischemic stroke model. The citicoline and lamotrigine combination did not provide a significant additive neuroprotective effect.
Ataus
Süreyya Ataus
SA
Department of Neurology, Akdeniz University Medical Faculty, Antalya, Turkey.
Onal
M Zülküf
MZ
Ozdem
Sadi S
SS
Locke
Kenneth W
KW
Balkan
Sevin
S
D000704:Analysis of Variance; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000033:anatomy & histology / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000209:etiology; D002544:Cerebral Infarction / Q000188:drug therapy / Q000209:etiology; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004359:Drug Therapy, Combination; D020244:Infarction, Middle Cerebral Artery / Q000150:complications / Q000188:drug therapy*; D000077213:Lamotrigine; D008297:Male; D009460:Neurologic Examination; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013778:Tetrazolium Salts; D016896:Treatment Outcome; D014227:Triazines / Q000627:therapeutic use*
D000927:Anticonvulsants; D013778:Tetrazolium Salts; D014227:Triazines; D003566:Cytidine Diphosphate Choline; C009591:triphenyltetrazolium; D000077213:Lamotrigine