title: Successful management of a pregnant woman with a TSH secreting pituitary adenoma with surgical and medical therapy.
abstract: We described a 39-yr-old asian female who was initially diagnosed with prolactinoma and presented with increase nervousness and weight loss. Laboratory evaluation revealed an inappropriately normal TSH level with elevated free T4, total T3, alpha-subunit and prolactin level. The alpha-subunit/TSH molar ratio was 4. MRI showed a macroadenoma extending to the suprasellar cistern. Treatment was begun with propylthiouracil and bromocriptine. After 5 months of therapy, she became pregnant. At 27 weeks of gestation, she developed headache and decreased visual acuity in her left eye. MRI showed a slightly increase in tumor size compressing the optic chaiasm. Transphenoid macroadenectomy was performed with immediate relief of the visual field abnormality. At 39 weeks gestation a baby with no malformations was delivered. This is the second case report of TSH secreting pituitary adenoma which was exarcerbated during pregnancy. In contrast to the first case, our case was managed with both surgical and medical approach. The judicious use of both medical and surgical therapy can result in a successful outcome to mother and fetus in a patient with TSH secreting pituitary adenoma.
authors.affiliation: Albert Einstein Medical Center, Philadelphia, PA, USA. Sumapac@yahoo.com
authors.forename: Sumapa
authors.initials: S
authors.lastname: Chaiamnuay
authors.forename: Mark
authors.initials: M
authors.lastname: Moster
authors.forename: M Richard
authors.initials: MR
authors.lastname: Katz
authors.forename: Young Nam
authors.initials: YN
authors.lastname: Kim
mesh_terms: D000236:Adenoma / Q000378:metabolism* / Q000601:surgery / Q000628:therapy*; D000328:Adult; D013956:Antithyroid Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D010907:Pituitary Hormones / Q000097:blood; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000601:surgery / Q000628:therapy*; D011247:Pregnancy; D011441:Propylthiouracil / Q000008:administration & dosage / Q000627:therapeutic use; D013972:Thyrotropin / Q000378:metabolism*
chemical_list: D013956:Antithyroid Agents; D010907:Pituitary Hormones; D011441:Propylthiouracil; D013972:Thyrotropin