Cross-couplings of alkyl electrophiles under "ligandless" conditions: Negishi reactions of organozirconium reagents.
This report establishes that simple, "ligandless" palladium complexes can catalyze the first zirconium-Negishi reactions of alkyl electrophiles. In view of the attractiveness of ligandless catalysts (cost, simplicity, and ease of purification), these observations add a significant and intriguing new dimension to the development of effective palladium-based processes for coupling alkyl electrophiles.
Wiskur
Sheryl L
SL
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. gcf@mit.edu
Korte
Alexander
A
Fu
Gregory C
GC
D000475:Alkenes / Q000138:chemical synthesis*; D002384:Catalysis; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D015040:Zirconium / Q000737:chemistry*
D000475:Alkenes; D006842:Hydrocarbons, Brominated; D009942:Organometallic Compounds; D010165:Palladium; D015040:Zirconium