A novel simian immunodeficiency virus isolated from a Schmidt's guenon (Cercopithecus ascanius schmidti).
A novel simian immunodeficiency virus (SIV) was characterized from a Schmidt's guenon (Cercopithecus ascanius schmidti), which was housed in a local zoo. The virus infection was detected during a routine serological screening for antibodies that were cross-reactive with SIVmac antigens. Infection with an immunodeficiency virus was confirmed using an INNO-LIA HIV Confirmation assay. Using DNA isolated from a blot clot, a 1895 nt partial pol sequence was amplified and sequenced. Phylogenetic analysis showed that this virus, designated SIVschm, shares a distant relationship with SIVgsn, isolated from greater spot-nosed monkeys, and is one of the most divergent SIVs identified to date.
Verschoor
Ernst J
EJ
Department of Virology, Biomedical Primate Research Centre (BPRC), PO Box 3306, 2206 GH Rijswijk, The Netherlands.
Fagrouch
Zahra
Z
Department of Virology, Biomedical Primate Research Centre (BPRC), PO Box 3306, 2206 GH Rijswijk, The Netherlands.
Bontjer
Ilja
I
Department of Virology, Biomedical Primate Research Centre (BPRC), PO Box 3306, 2206 GH Rijswijk, The Netherlands.
Niphuis
Henk
H
Department of Virology, Biomedical Primate Research Centre (BPRC), PO Box 3306, 2206 GH Rijswijk, The Netherlands.
Heeney
Jonathan L
JL
Department of Virology, Biomedical Primate Research Centre (BPRC), PO Box 3306, 2206 GH Rijswijk, The Netherlands.
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D002521:Cercopithecus / Q000145:classification / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D015684:Gene Products, pol / Q000737:chemistry / Q000235:genetics; D015488:HIV Antigens / Q000276:immunology; D006801:Humans; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D016097:Simian Acquired Immunodeficiency Syndrome / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification
D000914:Antibodies, Viral; D004279:DNA, Viral; D015684:Gene Products, pol; D015488:HIV Antigens