Biological activity of bacterial lectins and their molecular complexes with heterocyclic bis-adducts.
A new convenient method for the preparation of heterocyclic bis-adducts: of imidazole, benzimidazole, uracile with 1,1,1-trifluoro-2-bromo-2-chloroethane is described. The reactions are catalysed by the 18-crown-6-complex. The critical toxicity and antitumour activity of saprophytic strains Bacillus genus (B. subtilis 668 IMV and B. polymyxa 102 KSU) extracellular lectins were studies. It was discovered that these substances apply to a few toxic preparations and have a expression antitumour action on the tumours: Walker carcinosarcoma 256, Pliss' lymphosarcoma and Sarcoma 45. The new molecular complexes were created with bacterial lectins and the same heterocyclic-bis-adducts of unsubstituted benzimidazole and 6-methyluracile. A strongly antitumour effect of these complexes has been discovered: of growth relaxation of Pliss' lymphosarcoma tumour mass was 62.5-82.01%.
Welchinskaya
H V
HV
National Medical University, 13 Shevchenko Blvd, Kyiv, 01004, Ukraine.
Piecuszak
B
B
Kovalenko
E A
EA
Sharykina
N I
NI
Getman
K I
KI
Podgorsky
V S
VS
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use* / Q000633:toxicity; D001407:Bacillus / Q000737:chemistry; D001562:Benzimidazoles / Q000737:chemistry; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D043844:Crown Ethers; D006221:Halothane / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000627:therapeutic use; D007093:Imidazoles / Q000737:chemistry; D037102:Lectins / Q000737:chemistry* / Q000627:therapeutic use* / Q000633:toxicity; D007928:Lethal Dose 50; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy; D014498:Uracil / Q000737:chemistry
D000970:Antineoplastic Agents; D001562:Benzimidazoles; D043844:Crown Ethers; D006571:Heterocyclic Compounds; D007093:Imidazoles; D037102:Lectins; D014498:Uracil; C015762:18-crown-6; C029899:imidazole; C031000:benzimidazole; D006221:Halothane