title: Bioartificial pancreas research in Japan.
abstract: The bioartificial pancreas (BAP), a medical device enclosing insulin-secreting cells in a semipermeable membrane, is expected to physiologically control glucose levels, and thus to be able to inhibit development of serious chronic complications in diabetic patients. In this brief review, we introduce research activities on the development of the BAP in Japan, including membrane preparation for the BAP, evaluation of in vitro and in vivo BAP functions, and challenges for production of insulin-secreting cells from stem cells.
authors.affiliation: Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan. iwata@frontier.kyoto-u.ac.jp
authors.forename: Hiroo
authors.initials: H
authors.lastname: Iwata
authors.forename: Hideki
authors.initials: H
authors.lastname: Simada
authors.forename: Eisai
authors.initials: E
authors.lastname: Fukuma
authors.forename: Takahisa
authors.initials: T
authors.lastname: Ibii
authors.forename: Hideki
authors.initials: H
authors.lastname: Sato
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D003922:Diabetes Mellitus, Type 1 / Q000628:therapy*; D004622:Embryo, Mammalian / Q000166:cytology; D004867:Equipment Design; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D016381:Islets of Langerhans Transplantation; D007564:Japan; D051379:Mice; D019397:Pancreas, Artificial; D013234:Stem Cells / Q000166:cytology
chemical_list: D007328:Insulin