title: Early physiological development of infants with intrauterine growth retardation.
abstract: OBJECTIVE
  To assess the patterns of early postnatal physiological adaptation and maturation in intrauterine growth retarded (IUGR) infants by measuring changes in sleeping deep body temperature, heart rate, and concentrations of urinary cortisol.
  
  
  METHODS
  At home.
  
  
  METHODS
  Sixty five IUGR babies and 127 controls matched for sex, social class, and levels of parental smoking.
  
  
  RESULTS
  Night time sleeping deep body temperature, heart rate, and cortisol excretion fell with age, eventually establishing an adult type diurnal rhythm of physiological function. Minimum overnight temperature showed a linear decline with age (p < 0.001), but the IUGR infants and the controls had significant differences in intercept (p = 0.007) and slope (p = 0.02). The estimated rate of decline per week was 0.020 degrees C for IUGR infants and 0.031 degrees C for controls. Maximum temperature did not show similar changes. IUGR infants had a mean (SE) age adjusted minimum overnight heart rate that was 4.2 (1.5) beats/min (p = 0.005) higher than controls. Overnight cortisol/creatinine ratios declined with age at a rate of 4.1% per week (log ratio -0.421 (0.0165), p = 0.01), but the ratio for IUGR infants was on average 42% higher (log ratio 0.35 (0.11), p = 0.002) than for controls of the same age. Morning cortisol concentrations did not show a similar pattern.
  
  
  CONCLUSIONS
  Postnatal physiological adaptation and maturation of IUGR infants is slower than normal and therefore they remain in a physiologically immature state for longer. The higher heart rates and greater cortisol excretion in such infants may be precursors to hypertension and cardiovascular disease seen in adults.
authors.affiliation: Department of Child Health, University of Leicester and University of Warwick, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Jackson
authors.forename: M P
authors.initials: MP
authors.lastname: Wailoo
authors.forename: J R
authors.initials: JR
authors.lastname: Thompson
authors.forename: S A
authors.initials: SA
authors.lastname: Petersen
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology; D000367:Age Factors; D001831:Body Temperature / Q000502:physiology; D002657:Child Development / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology; D003404:Creatinine / Q000652:urine; D005317:Fetal Growth Retardation / Q000503:physiopathology* / Q000652:urine; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D007223:Infant; D012890:Sleep / Q000502:physiology; D012923:Social Class
chemical_list: D003404:Creatinine; D006854:Hydrocortisone