Collaborative interactions between growth factors and the extracellular matrix.
The contribution of extracellular matrix (ECM) components to the regulation of cell adhesion, proliferation and differentiation is receiving much attention. Recently, it has become evident that certain cellular responses require the combined action of ECM components and soluble growth factors. This article examines possible mechanisms underlying the synergistic interactions of growth factors and the ECM.
Schubert
D
D
The Salk Institute, PO Box 85800, San Diego, CA 92186-5800, USA.