title: The use of data mining to investigate a possible quality problem with ultrasensitive HIV viral load data at a large reference laboratory.
abstract: Suppression of HIV viral load to <50 copies/mL, the lower limit of detection for the ultrasensitive assays, has been shown to correlate with favorable clinical outcome. Patients periodically exhibited transient or sustained low-level viremia based on this test. In order to investigate a possible quality concern, we used our corporate data warehouse to examine the patterns in our data over time as well as across geographic regions.
authors.affiliation: Quest Diagnostics Incorporated, Advanced Diagnostics IT, Teterboro, NJ, USA.
authors.forename: Eileen
authors.initials: E
authors.lastname: Koski
authors.forename: Peter N R
authors.initials: PN
authors.lastname: Heseltine
authors.forename: Ron M
authors.initials: RM
authors.lastname: Kagan
authors.forename: Ann E
authors.initials: AE
authors.lastname: Maddo
authors.forename: Jake
authors.initials: J
authors.lastname: Geller
mesh_terms: D003627:Data Interpretation, Statistical; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D019451:Information Management; D016247:Information Storage and Retrieval; D007753:Laboratories / Q000592:standards; D011785:Quality Assurance, Health Care; D012367:RNA, Viral / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000592:standards*; D019562:Viral Load; D014766:Viremia / Q000175:diagnosis*
chemical_list: D012367:RNA, Viral