Effect of drying methods on retention of moist sucralfate gel properties.
The aim of this work was to find a drying procedure for moist sucralfate gel capable of producing dried sucralfate gel that retains the original gel properties of bioadhesion, rheology, and micromeritics. Spray-drying and microwave-drying procedures were employed. Mannitol was used as a gel-protective substance during the drying processes. The spray drying of moist sucralfate gel gave rise to a powder whose water suspensions showed significantly reduced viscosity. The bioadhesion of spray-dried sucralfate gel was strongly reduced by drying. When mannitol was used as a gel protector, the spray-dried sucralfate in part maintained the original bioadhesion of moist sucralfate gel. The preparation of a dried sucralfate gel retaining the bioadhesion characteristics, avoiding the use of mannitol, was made possible using the microwave-drying procedure. The microwave-dried product possesses a granular morphology suitable for direct compression because it is a free flowing and strongly coherent granular powder.
Maggi
L
L
Department of Pharmacy, University of Parma, Parco Area delle Scienze, 43100 Parma, Italy.
Catellani
P L
PL
Fisicaro
E
E
Santi
P
P
Zani
F
F
Massimo
G
G
Colombo
P
P
D000136:Acid-Base Equilibrium; D000818:Animals; D003102:Colloids / Q000737:chemistry; D003890:Desiccation / Q000379:methods*; D005753:Gastric Mucosa / Q000737:chemistry / Q000378:metabolism; D005782:Gels / Q000737:chemistry* / Q000378:metabolism; D012212:Rheology / Q000379:methods; D013392:Sucralfate / Q000737:chemistry* / Q000378:metabolism; D013535:Suspensions; D013552:Swine; D000267:Tissue Adhesions / Q000378:metabolism; D014867:Water / Q000737:chemistry*
D003102:Colloids; D005782:Gels; D013535:Suspensions; D014867:Water; D013392:Sucralfate