title: Lack of a genetic association between the TNXB locus and schizophrenia in a Chinese population.
abstract: A recent study demonstrated that the tenascin X (TNXB) gene was associated with schizophrenia in a British population. To replicate the initial finding, we analysed two positive single nucleotide polymorphisms (SNPs), rs1009382 and rs204887 present at the TNXB locus, in a Chinese population by using PCR-based restriction fragment length polymorphism analysis. We recruited a total of 136 family trios consisting of fathers, mothers and affected offspring with schizophrenia. The transmission disequilibrium test did not show allelic association between these two SNPs and schizophrenia, and the rs1009382-rs204887 haplotypes were not associated with the illness either. The present results suggest that the TNXB locus does not appear to be associated with schizophrenia in the Chinese population. Because the TNXB gene is less than 100 kb away from the NOTCH4 locus that was also reported to be associated with schizophrenia, allelic and locus heterogeneity could be possible reasons for the failure to replicate the TNXB finding.
authors.affiliation: Jilin University Research Center for Genomic Medicine, School of Public Health, Jilin University, Changchun 130021, China.
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Wei
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiu-Yi
authors.initials: XY
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.forename: Shu-Zheng
authors.initials: SZ
authors.lastname: Liu
authors.forename: Gui-Zhi
authors.initials: GZ
authors.lastname: Ju
authors.forename: Jie-Ping
authors.initials: JP
authors.lastname: Shi
authors.forename: Ya-Qin
authors.initials: YQ
authors.lastname: Yu
authors.forename: Qi
authors.initials: Q
authors.lastname: Xu
authors.forename: Gwynneth P
authors.initials: GP
authors.lastname: Hemmings
mesh_terms: D002681:China; D002874:Chromosome Mapping; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D018740:Genetic Heterogeneity; D008040:Genetic Linkage / Q000235:genetics; D005820:Genetic Testing; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000235:genetics*; D019063:Tenascin / Q000235:genetics*
chemical_list: D019063:Tenascin; C081865:tenascin X