title: Esophagitis impairs esophageal smooth muscle reactivity in the rat model: an in vitro study.
abstract: The present study investigated how reflux-induced esophagitis affects the smooth muscle reactivity of the esophageal body. Two different esophagitis models were used: acid gastric and mixed duodenogastric reflux. All test animals apart from the controls developed gross and histologic evidence of esophagitis. Contractile (carbachol and KCI) and relaxant (isoproterenol) esophageal smooth muscle responses were significantly decreased in the presence of acid- and mixed reflux-induced esophagitis. Similar relaxant responses to serotonin and papaverine were found in the three groups. Our study demonstrated impaired esophageal smooth muscle reactivity when esophagitis was induced by acid or mixed reflux. These changes may correspond to the functional motor abnormalities of the esophagus seen in patients with reflux esophagitis.
authors.affiliation: Department of Pediatric Surgery, Kocaeli University Medical School, Kocaeli, Turkey. tugaym@hotmail.com
authors.forename: Melih
authors.initials: M
authors.lastname: Tugay
authors.forename: Firuzan
authors.initials: F
authors.lastname: Yildiz
authors.forename: Tijen
authors.initials: T
authors.lastname: Utkan
authors.forename: Bahar
authors.initials: B
authors.lastname: Müezzinoğlu
authors.forename: Faruk
authors.initials: F
authors.lastname: Erden
authors.forename: Nejat
authors.initials: N
authors.lastname: Gacar
authors.forename: Güner
authors.initials: G
authors.lastname: Ulak
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004383:Duodenogastric Reflux / Q000150:complications*; D004942:Esophagitis, Peptic / Q000209:etiology* / Q000503:physiopathology*; D004947:Esophagus / Q000503:physiopathology*; D005764:Gastroesophageal Reflux / Q000150:complications*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar