Losartan induced fetal toxicity.
Losartan is a specific angiotensin II receptor antagonist. Although the teratogenic effects of angiotensin converting enzyme (ACE) inhibitors are well documented there are limited reports of losartan induced fetal toxicity. The authors report a case of incomplete ossification of skull bones, transient oliguria and feed intolerance in a newborn following in-utero exposure to losartan.
Nayar
Bonilla
B
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India.
Singhal
Ashwani
A
Aggarwal
Rajiv
R
Malhotra
Neena
N
D000014:Abnormalities, Drug-Induced; D000959:Antihypertensive Agents / Q000506:poisoning*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D006330:Heart Defects, Congenital / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D019808:Losartan / Q000506:poisoning*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy
D000959:Antihypertensive Agents; D019808:Losartan