Clinical experience with minocycline and rifampin-impregnated central venous catheters in bone marrow transplantation recipients: efficacy and low risk of developing staphylococcal resistance.
In this retrospective evaluation of the 4-year clinical use of minocycline and rifampin-impregnated catheters in bone marrow transplantation (BMT) patients, we report low risk of development of staphylococcal resistance to the antibiotics coating the catheters and efficacy in preventing primary staphylococcal bloodstream infections.
Chatzinikolaou
Ioannis
I
Department of Infectious Diseases, Infectious Control and Employee Health, University of Texas, M. D. Anderson Cancer Center, Houston 77030, USA.
Hanna
Hend
H
Graviss
Linda
L
Chaiban
Gassan
G
Perego
Cheryl
C
Arbuckle
Rebecca
R
Champlin
Richard
R
Darouiche
Rabih
R
Samonis
George
G
Raad
Issam
I
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D000904:Antibiotics, Antitubercular / Q000008:administration & dosage* / Q000494:pharmacology; D016026:Bone Marrow Transplantation / Q000295:instrumentation; D002405:Catheterization, Central Venous / Q000009:adverse effects / Q000295:instrumentation*; D002408:Catheters, Indwelling / Q000382:microbiology*; D015331:Cohort Studies; D003428:Cross Infection / Q000209:etiology / Q000517:prevention & control*; D016503:Drug Delivery Systems; D004351:Drug Resistance; D005260:Female; D006801:Humans; D017053:Infection Control / Q000379:methods; D007938:Leukemia / Q000601:surgery; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000008:administration & dosage* / Q000494:pharmacology; D009503:Neutropenia / Q000382:microbiology / Q000517:prevention & control*; D012293:Rifampin / Q000008:administration & dosage* / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000209:etiology / Q000517:prevention & control*; D013781:Texas
D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D008911:Minocycline; D012293:Rifampin