Sinonasal neuroendocrine carcinoma in association with SIADH.
BACKGROUND
Neuroendocrine carcinoma (NEC) is a rare malignancy of the nasal cavity or paranasal sinuses. The syndrome of inappropriate ADH secretion (SIADH) has not been previously reported in association with this cancer.


METHODS
We report a 30-year-old woman with histologically confirmed neuroendocrine carcinoma who also demonstrated SIADH. After successful chemotherapy and radiotherapy treatment for the neoplasm, her SIADH resolved. A literature search found eight cases of olfactory neuroblastoma (ONB) associated with SIADH, four of which resolved after treatment of the malignancy.


RESULTS
Treatment of the underlying malignancy resulted in the immediate resolution of the SIADH.


CONCLUSIONS
We report the first case of SIADH associated with NEC, which resolved after treatment of the cancer. A direct cause and effect between ONB/nasal NEC and SIADH has been established in previous reports.
Vasan
Nilesh R
NR
Department of Otorhinolaryngology, The University of Oklahoma Health Sciences Center, P.O. Box 26901, WP 1360, Oklahoma City, Oklahoma 73190, USA.
Medina
Jesus E
JE
Canfield
Vikki A
VA
Gillies
Elizabeth M
EM
D000328:Adult; D018278:Carcinoma, Neuroendocrine / Q000150:complications* / Q000628:therapy; D005260:Female; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000150:complications* / Q000628:therapy; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000150:complications* / Q000628:therapy