New screening method for the determination of stability of pharmaceuticals.
A rapid method for obtaining the parameters describing the lengths of oxidation induction periods from non-isothermal differential scanning calorimetry measurements, based on the dependence of onset temperature of the oxidation peak on heating rate, is presented. The method has been applied for screening the stability of a set of three pharmaceuticals. The order of stabilities of the compounds obtained by the method coincides with the order determined by classical stability tests.
Simon
Peter
P
Department of Physical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, Bratislava SK-812 37, Slovak Republic. simon@cvt.stuba.sk
Veverka
Miroslav
M
Okuliar
Jozef
J
D002152:Calorimetry, Differential Scanning; D004355:Drug Stability; D006358:Hot Temperature; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000737:chemistry*
D004364:Pharmaceutical Preparations