title: Isolated translocation of Wernicke's area to the right hemisphere in a 62-year-man with a temporo-parietal glioma.
abstract: We describe a case of translocation of temporo-parietal language function (Wernicke's area) to the contralateral hemisphere in a right-handed patient with a left temporo-parietal glioma. This translocation was identified by functional MR imaging (fMRI) and validated by direct cortical stimulation during gross-total resection. The current case exemplifies how preoperative fMRI can identify unexpected language organization as a result of tumor growth, affording surgery to patients who may otherwise be deemed inoperable.
authors.affiliation: Department of Radiology, Advanced Neuroimaging Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Petrovich
authors.forename: Andrei I
authors.initials: AI
authors.lastname: Holodny
authors.forename: Cameron W
authors.initials: CW
authors.lastname: Brennan
authors.forename: Philip H
authors.initials: PH
authors.lastname: Gutin
mesh_terms: D001932:Brain Neoplasms / Q000175:diagnosis*; D003399:Craniotomy; D005910:Glioma / Q000175:diagnosis*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D011859:Radiography; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery