title: Screening for familial combined hyperlipidemia in children using lipid phenotypes.
abstract: The purpose of this study was to screen for FCHL in children using serum lipid phenotypes. The subjects were 1190 (599 male, 591 female) children who participated in a screening and care program for life style-related diseases in school children. Total cholesterol, high-density lipoprotein cholesterol and triglyceride were determined, and information on the family history of parents was obtained by questionnaire. Candidates for FCHL were screened by the following criteria; type IIb hyperlipidemia, type IIa hyperlipidemia with positive family history of CHD, hyperlipidemia or both. We informed them of the results by mail. A second series of examinations to diagnose FCHL was performed on volunteer participants, including their parents. The candidates consisted of 9 children with type IIb and 27 with type IIa hyperlipidemia, 11 of whom participated, in the second series of examinations, in which 5 children were diagnosed with FCHL. The prevalence was 0.4%, suggesting that at least half of all individuals with FCHL already demonstrate hyperlipidemia in childhood.
authors.affiliation: Department of Pediatrics, Nihon University School of Medicine, Tokyo, Japan. fuji-wakakusa@muh.biglobe.ne.jp
authors.forename: Fujihiko
authors.initials: F
authors.lastname: Iwata
authors.forename: Tomoo
authors.initials: T
authors.lastname: Okada
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kuromori
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Hara
authors.forename: Kensuke
authors.initials: K
authors.lastname: Harada
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D006950:Hyperlipidemia, Familial Combined / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D008055:Lipids / Q000097:blood; D008297:Male; D008403:Mass Screening / Q000379:methods*; D010641:Phenotype; D015995:Prevalence
chemical_list: D008055:Lipids