title: Prognostic markers in resected stage I and II non small-cell lung cancer: an analysis of 260 patients with 5 year follow-up.
abstract: We performed a retrospective analysis of potential prognostic markers in 260 patients with surgically resected stage I and II non small-cell lung cancer (NSCLC) with a minimum 5-year follow-up. Cox proportional hazard models and Wilcoxon tests were employed to analyze the effect of patient characteristics on survival and disease-free survival (DFS). In the univariate analysis, the following were significant predictors of shorter overall survival: N-stage (N1 vs N0) (p<0.001); T-stage (T2 vs T1) (p<0.001); antigen A (loss vs presence) (p<0.01); cough (present vs absent) (p=0.01); bcl-2 expression (positive vs negative) (p=0.03); age (>63.5 vs <63.5) (p=0.03); mucin (positive vs negative) (p<0.03). The following were significant predictors of shorter DFS: N-stage (p<0.001); T-stage (p=0.001); loss of antigen A (p=0.01); mucin expression (p<0.01); cough (p=0.02); Ki-67 expression (p=0.02) and negative bcl-2 expression (p=0.03). Analysis of survival difference for histologic subtype, degree of differentiation, aneuploidy, %S-phase, codon 12 K-ras mutation, and immunohistochemistry staining for Lewisy, p53, Rb, microvessel count, HER2, E-cadherin and neuroendocrine markers did not reach statistical significance. In multivariate analysis, the following predicted for shorter overall survival: N-stage (p<0.01), antigen A (p=0.01), age (p<0.01), and bcl-2 (p=0.05); and for DFS, N-stage (p<0.01), antigen A (p<0.01), Ki-67 (p=0.03), mucin (p=0.04) and T-stage (p=0.05). Of all the clinical-pathological, proliferative, and biological markers studied, only a few carried independent prognostic significance.
authors.affiliation: Department of Medicine, Veteran Affiars Medical Center and State University of New York Health Sciences Center, Syracuse, NY 13210, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Mehdi
authors.forename: A H
authors.initials: AH
authors.lastname: Tatum
authors.forename: N B
authors.initials: NB
authors.lastname: Newman
authors.forename: G P
authors.initials: GP
authors.lastname: Gamble
authors.forename: J E
authors.initials: JE
authors.lastname: Etzell
authors.forename: N
authors.initials: N
authors.lastname: Weidner
authors.forename: J A
authors.initials: JA
authors.lastname: Kern
authors.forename: S M
authors.initials: SM
authors.lastname: Sorscher
authors.forename: L J
authors.initials: LJ
authors.lastname: Kohman
authors.forename: S L
authors.initials: SL
authors.lastname: Graziano