[Changes and significance of orphanin and serotonin in patients with postpartum depression].
OBJECTIVE
To study the changes of orphanin (OFQ) and serotonin (5-HT) in the patients with postpartum depression (PPD).


METHODS
Twenty one patients with postpartum depression (PPD group) and 25 healthy lying-in women (control group) were studied. The concentrations of plasma OFQ were measured by radioimmunoassay. The levels of 5-HT were measured with high-pressure liquid chromatography with electrochemical detector.


RESULTS
(1) The levels of plasma OFQ in PPD group were (28.5 +/- 5.8) ng/L, in control group, the levels of OFQ was (10.4 +/- 3.7) ng/L, the levels of OFQ in PPD group were significantly higher than that in the control group (P < 0.01). (2) The levels of plasma 5-HT in PPD group and control group were (1.0 +/- 0.3) micro mol/L and (1.4 +/- 0.4) micro mol/L respectively, the levels of 5-HT in PPD group decreased significantly (P < 0.05). (3) In the PPD group, there was a significant negative correlation between the OFQ and 5-HT level (P < 0.05).


CONCLUSIONS
The PPD was associated with OFQ and 5-HT, the changes of OFQ levels may play an important role in the pathogenesis of the PPD.
Gu
Hang
H
Department of Obstetrics and Gynecology, Affiliated Changhai Hospital of the Second Military Medical University, Shanghai 200433, China.
Hu
Dian
D
Hong
Xin-ru
XR
Mao
Jie
J
Cui
Ying
Y
Hui
Ning
N
Sha
Jin-yan
JY
D000328:Adult; D016022:Case-Control Studies; D002681:China; D019052:Depression, Postpartum / Q000097:blood*; D004563:Electrochemistry; D005260:Female; D006801:Humans; D018847:Opioid Peptides / Q000097:blood*; D011863:Radioimmunoassay; D012701:Serotonin / Q000097:blood*; D000097629:Nociceptin
D018847:Opioid Peptides; D012701:Serotonin; D000097629:Nociceptin