title: Can polyclonal intravenous immunoglobulin limit cytokine mediated cerebral damage and chronic lung disease in preterm infants?
abstract: Recent evidence suggests that inflammatory cytokines may play an important role in cerebral and pulmonary injury, especially in preterm infants. Immunomodulatory agents may help to limit such injury by reducing inflammation. Immunoglobulin has multiple anti-inflammatory properties and can modulate the inflammatory cytokine response. New evidence is required to test the hypotheses that prophylaxis or treatment with intravenous immunoglobulin may limit such inflammatory damage.
authors.affiliation: Department of Paediatrics, Baylor College of Medicine, Houston, TX 77025, USA. suseela12@hotmail.com
authors.forename: P V
authors.initials: PV
authors.lastname: Mohan
authors.forename: W
authors.initials: W
authors.lastname: Tarnow-Mordi
authors.forename: B
authors.initials: B
authors.lastname: Stenson
authors.forename: P
authors.initials: P
authors.lastname: Brocklehurst
authors.forename: K
authors.initials: K
authors.lastname: Haque
authors.forename: V
authors.initials: V
authors.lastname: Cavendish
authors.forename: A
authors.initials: A
authors.lastname: Cust
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000276:immunology; D001927:Brain Diseases / Q000276:immunology*; D002908:Chronic Disease; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage* / Q000276:immunology; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000276:immunology*; D007275:Injections, Intravenous; D007378:Interleukins / Q000276:immunology; D008171:Lung Diseases / Q000276:immunology*; D010431:Pentoxifylline / Q000276:immunology; D010726:Phosphodiesterase Inhibitors / Q000276:immunology; D013256:Steroids / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents; D016207:Cytokines; D007136:Immunoglobulins; D007378:Interleukins; D010726:Phosphodiesterase Inhibitors; D013256:Steroids; D014409:Tumor Necrosis Factor-alpha; D010431:Pentoxifylline