Immunosuppressive diterpenes from Veronicastrum sibiricum.
Two new diterpenes, named sibiriquinone A (1) and B (2), along with four known diterpenes have been isolated from the aerial part of Veronicastrum sibiricum. Their structures were elucidated by spectroscopy. The isolated compounds showed significant immunosuppressive activities.
Gao
Wenyuan
W
The College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072, China.
Zhang
Rong
R
Jia
Wei
W
Zhang
Jun
J
Takaishi
Yoshihisa
Y
Duan
Hongquan
H
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008968:Molecular Conformation; D051381:Rats; D028083:Scrophulariaceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
D004224:Diterpenes; D007166:Immunosuppressive Agents; D003907:Dexamethasone