title: Lymphoma complicating common variable immunodeficiency with granulomatous disease: report of two cases.
abstract: Common variable immunodeficiency (CVID) is a primary defect that is characterized by impaired antibody production. CVID patients may develop recurrent infections, autoimmune disorders and/or systemic granulomatosis. It is well documented that CVID patients are at risk to develop malignant lymphomas. However, to the best of our knowledge, lymphoma complicating the course of CVID associated with systemic granulomatosis has never been reported. We describe two CVID patients with systemic granulomatosis who developed B-cell lymphomas, one related to Epstein Barr virus infection, 5 and 12 yr after CVID had been diagnosed.
authors.affiliation: Department of Internal Medicine, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris and Université Paris-Nord, Bobigny, France.
authors.forename: Véronique
authors.initials: V
authors.lastname: Le Guern
authors.forename: Geneviève
authors.initials: G
authors.lastname: Le Roux
authors.forename: Antoine
authors.initials: A
authors.lastname: Martin
authors.forename: Jean
authors.initials: J
authors.lastname: Feuillard
authors.forename: Pascal
authors.initials: P
authors.lastname: Cohen
authors.forename: Hélène
authors.initials: H
authors.lastname: Poirel
authors.forename: Martine
authors.initials: M
authors.lastname: Raphaël
authors.forename: Loïc
authors.initials: L
authors.lastname: Guillevin
authors.forename: Luc
authors.initials: L
authors.lastname: Mouthon
mesh_terms: D001402:B-Lymphocytes / Q000473:pathology; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000175:diagnosis; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D020031:Epstein-Barr Virus Infections; D017809:Fatal Outcome; D005260:Female; D006099:Granuloma / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D006529:Hepatomegaly; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000209:etiology* / Q000235:genetics / Q000821:virology; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis; D013163:Splenomegaly; D013601:T-Lymphocytes / Q000473:pathology
chemical_list: D012367:RNA, Viral