title: Experimental cadmium poisoning in sheep.
abstract: Pathomorphological investigations of internal organs were made in sheep given sublethal doses of cadmium. Early histological damages in kidneys were established by renal biopsy in some experimental animals. The main histological changes were characterized by granular degeneration in proximal tubules and glomerular endothelial proliferation in kidneys, granular degeneration in hepatocytes, pericapillary oedema and activation of capillary endothelium and Kupffer cells in liver, oedematous and degenerative changes in cerebrum and in the region of Purkinje cells of cerebellum, hyperplasia and proliferation of alveolar epithelium and perivascular or peribronchial mononuclear cell infiltration in lung, and degenerative changes in the medulla and zona glomerulosa of adrenal glands.
authors.affiliation: Department of General and clinical pathology, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria. stoev@uni-sz.bg
authors.forename: Stoycho D
authors.initials: SD
authors.lastname: Stoev
authors.forename: N
authors.initials: N
authors.lastname: Grozeva
authors.forename: R
authors.initials: R
authors.lastname: Simeonov
authors.forename: I
authors.initials: I
authors.lastname: Borisov
authors.forename: H
authors.initials: H
authors.lastname: Hubenov
authors.forename: Y
authors.initials: Y
authors.lastname: Nikolov
authors.forename: M
authors.initials: M
authors.lastname: Tsaneva
authors.forename: S
authors.initials: S
authors.lastname: Lazarova
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects / Q000473:pathology; D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D002105:Cadmium Poisoning / Q000473:pathology*; D002531:Cerebellum / Q000187:drug effects / Q000473:pathology; D022781:Hepatocytes / Q000187:drug effects / Q000473:pathology; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000473:pathology; D007728:Kupffer Cells / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D012756:Sheep
chemical_list: D002104:Cadmium