title: 3-Hydroxy-4-oxo-3,4-dihydro-5-azabenzo-1,2,3-triazene.
abstract: The known but long-neglected compound HODhat was shown to be in certain situations a useful peptide coupling additive. Uronium and phosphonium salts with HODhat built into the system were also useful stand-alone coupling reagents. Comparisons with related additives and coupling reagents showed that the new systems were sometimes more and sometimes less effective than previously described systems in the case of stepwise and segment couplings. Applications to assembly of the model decapeptide ACP showed that HDATU was far more effective than HDTU and more effective than HATU under some conditions.
authors.affiliation: Department of Chemistry, Box 34510, University of Massachusetts, Amherst, Massachusetts 01003-4510, USA. carpino@chem.umass.edu
authors.forename: Louis A
authors.initials: LA
authors.lastname: Carpino
authors.forename: Jusong
authors.initials: J
authors.lastname: Xia
authors.forename: Ayman
authors.initials: A
authors.lastname: El-Faham
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D013056:Spectrophotometry, Ultraviolet; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: C484678:3-hydroxy-4-oxo-3,4-dihydro-5-azabenzo-1,2,3-triazene; D014227:Triazines