title: The effect of a 2% zinc citrate, 0.3% Triclosan dentifrice on plaque acid production following consumption of a snackfood.
abstract: OBJECTIVE
  A) To assess plaque lactate production following consumption of three foods (cake, chocolate/caramel bar, sweetened coffee), and B) To measure the effect of a fluoride dentifrice containing 2% zinc citrate and 0.3% Triclosan on plaque lactate and pH drop following consumption of cake.
  
  
  METHODS
  A) 10 subjects completed the first study. Plaque samples taken before and at 8,15 and 30 minutes after eating. Samples were analysed for lactate via Capillary Electrophoresis. B) 30 subjects completed the second study. Plaque samples were taken before and after cake and use of test dentifrice or no treatment control. Plaque pH and lactate content were assessed.
  
  
  RESULTS
  A) Plaque lactate levels increased after all three foods; peak lactate levels occurred 8 minutes after eating. B) Plaque lactate concentrations after eating cake were 39.2mM for the control treatment and a significantly lower value, 23.6mM, for the test 2% zinc citrate, 0.3% Triclosan dentifrice. After food challenge, pH values were 5.53 for the no treatment group and a significantly higher value of 5.79 for the test dentifrice group.
  
  
  CONCLUSIONS
  A toothpaste containing 2% zinc citrate, 0.3% Triclosan can significantly reduce plaque lactate generation and pH drop induced by cake, compared to no treatment control.
authors.affiliation: Unilever Oral Care, Quarry Road East, Bebington, Wirral, UK. alison.green@unilever.com
authors.forename: A K
authors.initials: AK
authors.lastname: Green
authors.forename: C P
authors.initials: CP
authors.lastname: Horay
authors.forename: A M
authors.initials: AM
authors.lastname: Lloyd
authors.forename: P J
authors.initials: PJ
authors.lastname: Abraham
authors.forename: T F
authors.initials: TF
authors.lastname: Cox
authors.forename: J S
authors.initials: JS
authors.lastname: Holt
authors.forename: D J
authors.initials: DJ
authors.lastname: Savage
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002099:Cacao; D002182:Candy; D002327:Cariostatic Agents / Q000627:therapeutic use; D019343:Citric Acid / Q000627:therapeutic use*; D003069:Coffee; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000378:metabolism*; D003802:Dentifrices / Q000627:therapeutic use*; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D005502:Food; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016037:Single-Blind Method; D013997:Time Factors; D014260:Triclosan / Q000627:therapeutic use*; D015032:Zinc / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D003069:Coffee; D003802:Dentifrices; D019343:Citric Acid; D019344:Lactic Acid; D014260:Triclosan; D015032:Zinc; D005459:Fluorides