Slow cooling improved blood lipoprotein composition in hypertensive rats.
Under normal thermal conditions, hypertensive NISAG rats are characterized by lower plasma levels of high-density lipoproteins and increased coefficient of atherogenicity compared to normotensive Wistar rats. Slow cooling significantly modified fractional composition of plasma lipoproteins in hypertensive rats: decreased the content of low-density lipoproteins, markedly increased the content of high-density lipoproteins, and normalized coefficient of atherogenicity. Our results demonstrated the possibility of correcting disturbances in lipoprotein spectrum in essential hypertension by using thermal exposures.
Kozyreva
T V
TV
Laboratory of Thermophysiology, Institute of Physiology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. kozyreva@iph.ma.nsc.ru
Lomakina
S V
SV
Tuzikov
F V
FV
Tuzikova
N A
NA
D000818:Animals; D006973:Hypertension / Q000097:blood*; D007036:Hypothermia, Induced; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000032:analysis; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar
D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL