title: Testicular atrophy after bile duct ligation in chickens.
abstract: Testicular atrophy associated with biliary obstruction in chickens, produced by the ligation of both extrahepatic bile ducts, was examined grossly, histologically, immunohistochemically, and ultrastructurally. Grossly, reduction in testicular size and volume was evident in chickens that underwent bile duct ligation (BDL). Histologically, there was marked reduction in tubular diameter, peritubular fibrosis, loss of spermatogenic cells, and tubules lined only by Sertoli cells. In addition, Leydig cells, which accumulated in the interstitium of the testes, contained numerous large lipid vacuoles, as determined by electron microscopy. These features suggest that BDL in chickens causes hypogonadism and low serum testosterone.
authors.affiliation: Department of Veterinary Anatomy, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada Aomori 034, Japan. yoshioka@vmas.kitasato-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Yoshioka
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: S
authors.initials: S
authors.lastname: Imai
authors.forename: M
authors.initials: M
authors.lastname: Tsujio
authors.forename: K
authors.initials: K
authors.lastname: Taniguchi
authors.forename: K
authors.initials: K
authors.lastname: Mutoh
mesh_terms: D000818:Animals; D001284:Atrophy / Q000473:pathology / Q000662:veterinary; D001652:Bile Ducts; D002645:Chickens / Q000033:anatomy & histology*; D007150:Immunohistochemistry; D008026:Ligation / Q000662:veterinary; D008103:Liver Cirrhosis / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008854:Microscopy, Electron; D011201:Poultry Diseases / Q000473:pathology*; D013737:Testis / Q000473:pathology* / Q000648:ultrastructure; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone