Unsuccessful treatment with voriconazole of a brain abscess due to Cladophialophora bantiana.
Cladophialophora bantiana is a dematiaceous fungus, associated with brain abscess in normal or immunosuppressed patients. We report a case of CNS infection in this agent unsuccessfully treated by surgery and various antifungal compounds including high doses of voriconazole (6 mg/kg bid). No adverse effects related to this compound were observed.
Fica
Alberto
A
Sección Infectología, Hospital Clinico U de Chile, Santiago, Chile. afica@ns.hospital.uchile.cl
Diaz
Maria-Cristina
MC
Luppi
Mario
M
Olivares
Roberto
R
Saez
Lia
L
Baboor
Marcos
M
Vasquez
Patricio
P
D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage; D001922:Brain Abscess / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D020314:Central Nervous System Fungal Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D002963:Cladosporium / Q000145:classification / Q000187:drug effects*; D003131:Combined Modality Therapy; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D017809:Fatal Outcome; D016469:Fungemia / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011743:Pyrimidines / Q000008:administration & dosage*; D018570:Risk Assessment; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure; D014230:Triazoles / Q000008:administration & dosage*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole