Miniature endoscope for simultaneous optical coherence tomography and laser-induced fluorescence measurement.
We have designed a multimodality system that combines optical coherence tomography (OCT) and laser-induced fluorescence (LIF) in a 2.0-mm-diameter endoscopic package. OCT provides approximately 18-microm resolution cross-sectional structural information over a 6-mm field. LIF spectra are collected sequentially at submillimeter resolution across the same field and provide histochemical information about the tissue. We present the use of a rod prism to reduce the asymmetry in the OCT beam caused by a cylindrical window. The endoscope has been applied to investigate mouse colon cancer in vivo.
Tumlinson
Alexandre R
AR
University of Arizona, 1230 East Speedway Boulevard, Tucson, Arizona 85721-0104, USA.
Hariri
Lida P
LP
Utzinger
Urs
U
Barton
Jennifer K
JK
D000818:Animals; D020685:Colonoscopes; D003113:Colonoscopy; D004396:Coloring Agents; D019723:Endoscopes; D004867:Equipment Design; D005453:Fluorescence; D007834:Lasers; D051379:Mice; D041623:Tomography, Optical Coherence / Q000295:instrumentation*
D004396:Coloring Agents