title: Somatic complaints and isoniazid (INH) side effects in Latino adolescents with latent tuberculosis infection (LTBI).
abstract: This study examined the potential effects of INH side effects and non-specific somatic complaints on medication adherence in 96 Latino adolescents participating in a controlled trial designed to increase isoniazid (INH) adherence. These participants (who received usual medical care) were interviewed monthly over 9 months. Participants were questioned regarding medication taking, the frequency of 15 INH-related side effects from the Physician's Desk Reference (PDR) [1], and 21 non-specific somatic complaints. Participants were aged 12-19 years, 53.1% were male, 66.7% were born in Mexico, 73% had no health insurance, and 52.5% were classified as bicultural. Approximately 70% of participants experienced at least one side effect during the trial. Side effects that occurred while taking INH were not significantly related to total number of pills taken; somatic complaints that occurred during 9 months of INH were significantly negatively related to cumulative adherence. Females reported significantly more somatic complaints at baseline than males.
authors.affiliation: School of Nursing, University of California Los Angeles, 4254 Factor Building, 700 Tiverton, Los Angeles, CA 90095, USA.
authors.forename: J
authors.initials: J
authors.lastname: Berg
authors.forename: E J
authors.initials: EJ
authors.lastname: Blumberg
authors.forename: C L
authors.initials: CL
authors.lastname: Sipan
authors.forename: L S
authors.initials: LS
authors.lastname: Friedman
authors.forename: N J
authors.initials: NJ
authors.lastname: Kelley
authors.forename: A Y
authors.initials: AY
authors.lastname: Vera
authors.forename: C R
authors.initials: CR
authors.lastname: Hofstetter
authors.forename: M F
authors.initials: MF
authors.lastname: Hovell
mesh_terms: D000069:Acculturation; D000293:Adolescent; D000294:Adolescent Behavior / Q000208:ethnology; D000704:Analysis of Variance; D000995:Antitubercular Agents / Q000009:adverse effects*; D002140:California; D002648:Child; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006630:Hispanic or Latino / Q000193:education / Q000208:ethnology*; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D016018:Least-Squares Analysis; D008137:Longitudinal Studies; D008297:Male; D020380:Needs Assessment; D015404:Nursing Methodology Research; D010349:Patient Compliance / Q000208:ethnology*; D010353:Patient Education as Topic; D000297:Psychology, Adolescent; D012737:Sex Factors; D011795:Surveys and Questionnaires; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000208:ethnology
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid