Apoptosis: escaping strategies in human skin cancer (Review).
Apoptosis must be considered a rescue mechanism that controls the integrity of the cell erasing aberrant clones and it is likely that failure of apoptosis constitutes a key factor responsible for tumour formation, progression and resistance to drugs. Several genes (e.g. survivin, bcl-2 family, p53) are involved in these pathways. Much work still needs to be done to identify the molecular pathway of apoptosis resistance but restoration of the apoptotic response represents a crucial new therapeutic target for cancer treatment.
Giannetti
Luca
L
Institute of Dentistry and Surgery, Faculty of Medicine, University of Modena, Modena, Italy.
Consolo
Ugo
U
Magnoni
Cristina
C
Lo Muzio
Lorenzo
L
D017209:Apoptosis; D018450:Disease Progression; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D009154:Mutation; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology*