title: Efficient synthesis of akolactone A via Pd-catalyzed carbonylation.
abstract: The first synthesis of (+)- and (-)-akolactone A is described by using Pd-catalyzed carbonylation. A comparison of the optical rotation of both enantiomers of akolactone A and the natural compound suggests that the absolute configuration at the 4-position of akolactone A is R.
authors.affiliation: Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University, Kamiina, Nagano, Japan. makabeh@gipmc.shinshu-u.ac.jp
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Makabe
authors.forename: Motonori
authors.initials: M
authors.lastname: Okajima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Konno
authors.forename: Tsunashi
authors.initials: T
authors.lastname: Kamo
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Hirota
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; C492583:akolactone A; D015107:4-Butyrolactone