title: [Long-term follow-up after autologous submandibular gland transplantation in scarring keratoconjunctivitis with absolute dry eyes].
abstract: BACKGROUND
  An autologous submandibular gland can be transplanted to the temporal fossa and following microvascular anastomosis to the temporal artery and vein and implantation of the secretory duct into the superotemporal conjunctival fornix to provide continuous substitute lubrication. Here we report our experiences with this procedure.
  
  
  METHODS
  In a prospective, controlled clinical cohort study, we investigated the development of the Schirmer- test, fluorescein-break up time (F-BUT), degree of discomfort, use of pharmaceutical tear substitutes, visual acuity, Rose Bengal staining and conjunctival hyperemia in 14 eyes with a successful submandibular gland transplant and 11 dry eyes without salivary lubrication.
  
  
  RESULTS
  Over a mean postoperative period of 3.3 years the transplantation group showed significant improvements of the Schirmer-Test, FBUT, use of pharmaceutical tear substitutes, discomfort and Rose Bengal staining up to the last follow-up when compared to the preoperative and control groups.
  
  
  CONCLUSIONS
  Transplantation of an autologous submandibular gland can improve the lubrication and discomfort of absolute tear deficiency on a long term basis, but the salivary tear film only partially stabilises the ocular surface. The procedure is however able to provide symptomatic relief in extreme cases of absolute dry eyes.
authors.affiliation: Klinik für Augenheilkunde, Universitätsklinikum Lübeck. christina-schroeder@t-online.de
authors.forename: C
authors.initials: C
authors.lastname: Schröder
authors.forename: S G
authors.initials: SG
authors.lastname: Hakim
authors.forename: J R O
authors.initials: JR
authors.lastname: Collin
authors.forename: P
authors.initials: P
authors.lastname: Sieg
authors.forename: G
authors.initials: G
authors.lastname: Geerling
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007638:Keratoconjunctivitis Sicca / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013363:Submandibular Gland / Q000637:transplantation*; D013997:Time Factors; D014182:Transplantation, Autologous; D014792:Visual Acuity; D014985:Xerophthalmia / Q000175:diagnosis / Q000601:surgery*