title: Inhibitory actions of serotonin on glutamate release in dorsal medulla suppress systemic arterial pressure of cats.
abstract: The role of serotonin and glutamate release in dorsal medulla (DM) for regulation of systemic arterial pressure (SAP) was examined with microdialysis and high performance liquid chromatograph in anesthetized cats. KCl-perfusion in DM increased serotonin and glutamate concentrations in DM. Perfusion of serotonin resulted in decreases in glutamate concentration and SAP. Perfusion of alaproclate, a serotonin reuptake inhibitor that produced an increase in serotonin concentration in DM, had the same results as perfusion of serotonin. In conclusion, serotonin and glutamate appeared to be tonically and endogenously released from nerve terminals in DM, and the decrease in SAP could be attributed to the decreased glutamate release resulting from inhibitory action of serotonin in DM. The putative roles of serotonin and glutamate in DM may be important in SAP regulation.
authors.affiliation: Department of Physiology, School of Medicine, China Medical University, Taichung, Taiwan, ROC.
authors.forename: Chi-Li
authors.initials: CL
authors.lastname: Gong
authors.forename: Yung-Tsung
authors.initials: YT
authors.lastname: Chiu
authors.forename: Nai-Nu
authors.initials: NN
authors.lastname: Lin
authors.forename: Shinn-Zong
authors.initials: SZ
authors.lastname: Lin
authors.forename: Fu-Chou
authors.initials: FC
authors.lastname: Cheng
authors.forename: Jon-Son
authors.initials: JS
authors.lastname: Kuo
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D045604:Extracellular Fluid / Q000187:drug effects / Q000378:metabolism; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects / Q000378:metabolism*; D017551:Microdialysis; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology*; D011189:Potassium Chloride / Q000494:pharmacology; D017729:Presynaptic Terminals / Q000187:drug effects / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism* / Q000494:pharmacology; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*; D015854:Up-Regulation / Q000187:drug effects / Q000502:physiology
chemical_list: D000409:Alanine; D018698:Glutamic Acid; D011189:Potassium Chloride; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; C025293:alaproclate