The blood supply of the cat's visual cortex and its postnatal development.
We examined the blood supply of the cat's visual cortex using alkaline phosphatase histochemistry to demonstrate the capillary endothelial cells. In the adult, layer 4 is marked by a band that is of obviously greater density, extends throughout areas 17 and 18, and ends abruptly at the 18/19 border. We quantified blood vessel density in area 17, observing a 23% greater density in layer 4 than in supragranular and infragranular layers. This difference reflects a laminar difference in metabolic rate. In three animals studied using the metabolic marker 2-deoxyglucose, layer 4 was 25% denser than the other layers. The band of greater density in layer 4 is not present in newborn kittens, but becomes apparent at about 5 weeks of age. Early in development, the endothelial cells form filopodia as the capillaries grow and branch. The density of blood vessels decreases slightly during the first week of postnatal life, but increases between 1 and 6 weeks of age, so that by 6 weeks, the blood supply of the visual cortex resembles that seen in the adult. This pattern resembles that of cortical metabolism seen with 2-deoxyglucose [J. Cereb. Blood Flow Metab. 11 (1991) 35], but the increase in vascular density precedes that in glucose metabolism.
Tieman
Suzannah Bliss
SB
Center for Neuroscience Research and Department of Biological Sciences, The University at Albany, State University of New York, 1400 Washington Avenue, Albany, NY 12222, USA. tieman@albany.edu
Möllers
Sven
S
Tieman
David G
DG
White
Jacqueline
J
D000375:Aging / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D001808:Blood Vessels / Q000378:metabolism; D002415:Cats; D002452:Cell Count; D003847:Deoxyglucose / Q000378:metabolism; D005123:Eye; D005260:Female; D006651:Histocytochemistry / Q000379:methods; D008297:Male; D012683:Sensory Deprivation; D013569:Synapses / Q000502:physiology; D014793:Visual Cortex / Q000033:anatomy & histology / Q000098:blood supply* / Q000254:growth & development
D003847:Deoxyglucose; D000469:Alkaline Phosphatase