Photoallergic contact dermatitis from ketoprofen induced by drug-contaminated personal objects.
BACKGROUND
Photoallergic contact dermatitis from ketoprofen has been recognized since the mid-1980s. Skin reactions have been reported to continue weeks after discontinuation of ketoprofen. One reason for this could be residual ketoprofen in the skin, which has been shown in a skin biopsy specimen.


OBJECTIVE
We sought to report on 3 cases of photoallergic contact dermatitis from ketoprofen in topical anti-inflammatory gels and on relapses of dermatitis appearing after use of ketoprofen-contaminated objects.


METHODS
We patch and photopatch tested, with standard series, the anti-inflammatory gel, ketoprofen, and its ingredients in serial dilutions and extracts of personal objects. We performed chemical investigations of personal objects with thin-layer chromatography, high-pressure liquid chromatography, and gas chromatography-mass spectrometry.


RESULTS
Photoallergy was demonstrated to ketoprofen, which was detected in personal objects.


CONCLUSIONS
Relapses of photoallergic contact dermatitis in patients photoallergic to ketoprofen can be induced by ketoprofen-contaminated objects such as bandages and slippers.
Hindsén
Monica
M
Department of Occupationa and Enviromental Dermatology, Malmö Universty Hospital, Malmö, Sweden. monica.hindsen@derm.mas.lu.se
Isaksson
Marléne
M
Persson
Lena
L
Zimersson
Erik
E
Bruze
Magnus
M
D000287:Administration, Topical; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis; D001458:Bandages; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D017454:Dermatitis, Photoallergic / Q000209:etiology*; D004866:Equipment Contamination; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D049669:History, 16th Century; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012775:Shoes; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007660:Ketoprofen