[Expression of nuclear factor-kappaBP65 in human brain glioma and human brain metastatic carcinoma and its significance].
OBJECTIVE
To study the immunohistochemical changes of nuclear factor-kappaBP65 (NF-kappaBp65) in human brain glioma (HBG) and human brain metastatic carcinoma (HBMC) and the role of NF-kappaBP65 in the biological behavior of the tumors.


METHODS
The protein expression of NF-kappaBP65 were examined with SABC immunohistochemical technique in 18 HBG, 12 HBMC and 6 normal brain tissue samples, and the correlation between the expression and the biological behavior of the tumors was analyzed.


RESULTS
Normal brain tissues had only trace expression of NF-kappaBP65, whereas all tumor tissues examined expressed NF-kappaBP65. The level of NF-kappaBP65 in high-grade HBG, HBMC and recurrent HBG tissues was considerably higher than that in low-grade HBG tissues (PLT;0.01).


CONCLUSIONS
NF-kappaBP65 expression is associated with the malignant progression, invasion and angiogenesis of HBG and HBMC, and it may play a crucial role in the recurrence of HBG.
Tang
Wan-zhong
WZ
Department of Traumatology, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, China.
Xia
Yu-jun
YJ
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000737:chemistry* / Q000473:pathology / Q000556:secondary; D004247:DNA / Q000378:metabolism; D005260:Female; D005910:Glioma / Q000737:chemistry* / Q000473:pathology / Q000556:secondary; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000032:analysis*; D051996:Transcription Factor RelA
D016328:NF-kappa B; D051996:Transcription Factor RelA; D004247:DNA