title: [Mathematical model of epidermal growth factor receptor-mediated lipid phosphatidylinositol(4,5)-bisphosphate hydrolyzation by phospholipase C-gamma1 activity].
abstract: OBJECTIVE
  To investigate the dynamic characteristics of lipid phosphatidylinositol (4,5)-bisphosphate (PIP(2)) in plasma membrane hydrolyzed by phospholipase C-gamma1 in epidermal growth factor receptor(EGFR)-mediated signal pathway.
  
  
  METHODS
  A mathematical model based on the law of mass action was established with differential equations to simulate metabolizable pathway of PIP(2).
  
  
  RESULTS
  Differential equations of the key product concentration during hydrolysis of PIP(2) were formulated, and the effects of the parameters on these hydrolyzed products analyzed.
  
  
  CONCLUSIONS
  This mathematical model provides foundation for further investigation of the dynamic changes of biological characteristics and the relations between the key product concentrations in PIP2 hydrolysis.
authors.affiliation: Teaching and Research Section of Medical Physics, Department of Medical Engineering, First Military Medical University, Guangzhou 510515, China. suyc@fimmu.com
authors.forename: Yong-chun
authors.initials: YC
authors.lastname: Su
authors.forename: Fan
authors.initials: F
authors.lastname: Deng
authors.forename: Di
authors.initials: D
authors.lastname: Lu
authors.forename: Xiao-chun
authors.initials: XC
authors.lastname: Bai
authors.forename: Xiao-dan
authors.initials: XD
authors.lastname: Tan
authors.forename: Ai-rong
authors.initials: AR
authors.lastname: Dong
authors.forename: Shen-qiu
authors.initials: SQ
authors.lastname: Luo
authors.forename: Qin-kai
authors.initials: QK
authors.lastname: Deng
mesh_terms: D066246:ErbB Receptors / Q000502:physiology*; D006868:Hydrolysis; D008962:Models, Theoretical; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism*; D051966:Phospholipase C gamma; D010738:Type C Phospholipases / Q000502:physiology*
chemical_list: D019269:Phosphatidylinositol 4,5-Diphosphate; D066246:ErbB Receptors; D010738:Type C Phospholipases; D051966:Phospholipase C gamma