Lysosome recruitment during host cell invasion by Trypanosoma cruzi.
The protozoan parasite Trypanosoma cruzi uses an unusual mechanism to enter cells. Recent observations revealed that instead of trypanosomes being brought in to fuse with lysosomes, it is the lysosomes that migrate to the trypanosomes and actually participate in their internalization. Signalling events involving intracellular free Ca2+ occur upon contact of the parasites with host cells and may contribute to the regulation of this unusual process.
Andrews
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Dept of Cell Biology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA.