Becker muscular dystrophy in a patient with Hodgkin's disease.
Genetic disease often predisposes to neoplastic processes because of either alterations in both oncogenes and tumor suppressor genes or imbalances in the cell cycle. The authors present the case of a 15-year-old boy with Hodgkin's disease associated with Becker muscular dystrophy. Becker muscular dystrophy is an X-linked neuromuscular disease due to in-frame mutations in the dystrophin gene, and it is considered a milder variant of Duchenne muscular dystrophy. In most patients with Becker muscular dystrophy, the myopathic process affects the myocardium, leading to cardiomyopathy.
Cereda
Stefano
S
Pediatric Oncology Unit, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy.
Cefalo
Graziella
G
Terenziani
Monica
M
Catania
Serena
S
Fossati-Bellani
Franca
F
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003402:Creatine Kinase / Q000097:blood; D016189:Dystrophin / Q000032:analysis; D004562:Electrocardiography; D006689:Hodgkin Disease / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000000981:diagnostic imaging / Q000473:pathology; D020388:Muscular Dystrophy, Duchenne / Q000150:complications* / Q000175:diagnosis*; D011859:Radiography; D012074:Remission Induction
D016189:Dystrophin; D003402:Creatine Kinase