title: Extranodal Rosai-Dorfman disease in children.
abstract: Sinus histiocytosis with massive lymphadenopathy (SHML), or Rosai-Dorfman disease (RDD), is a histiocytic disorder that usually presents with painless massive cervical lymphadenopathy. The course is usually self-limited, but treatment may be required in cases with compression of vital organs. Patients may present with extranodal involvement only, and in these cases the clinical and histologic diagnosis may be difficult. The authors describe three patients with RDD who had exclusive extranodal disease in the head and neck area, in whom the clinical presentation mimicked other more common conditions.
authors.affiliation: Department of Hematology-Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
authors.forename: Carlos
authors.initials: C
authors.lastname: Rodriguez-Galindo
authors.forename: Kathleen J
authors.initials: KJ
authors.lastname: Helton
authors.forename: Niria D
authors.initials: ND
authors.lastname: Sánchez
authors.forename: Martha
authors.initials: M
authors.lastname: Rieman
authors.forename: Michael
authors.initials: M
authors.lastname: Jeng
authors.forename: Winfred
authors.initials: W
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005624:Frontal Bone / Q000473:pathology; D015618:Histiocytosis, Sinus / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D009916:Orbital Diseases / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents