title: Combined multiplanar optical coherence tomography and confocal scanning ophthalmoscopy.
abstract: We demonstrate the clinical application of a multiplanar imaging system that simultaneously acquires en face (C-scan) optical coherence tomography (OCT) and the corresponding confocal ophthalmoscopic images, along with cross-sectional (B-scan) OCT at specifiable locations on the confocal image. The advantages of the simultaneous OCT and confocal acquisition as well as the challenges of interpreting the C-scan OCT images are discussed. Variations in tissue inclination with respect to the coherence wave surface alter the sampling of structures within the depth of the retina, producing novel slice orientations that are often challenging to interpret. We have evaluated for the first time the utility of C-scan OCT for a variety of pathologies, including melanocytoma, diabetic retinopathy, choroidal neovascular membrane, and macular pucker. Several remarkable new aspects of clinical anatomy were revealed using this new technique. The versatility of selective capture of C-scan OCT images and B-scan OCT images at precise points on the confocal image affords the clinician a more complete and interactive tool for 3-D imaging of retinal pathology.
authors.affiliation: School of Physical Sciences, Applied Optics Group, University of Kent, Canterbury, United Kingdom. ap11@ukc.ac.uk
authors.forename: Adrian Gh
authors.initials: AG
authors.lastname: Podoleanu
authors.forename: George M
authors.initials: GM
authors.lastname: Dobre
authors.forename: Radu G
authors.initials: RG
authors.lastname: Cucu
authors.forename: Richard
authors.initials: R
authors.lastname: Rosen
authors.forename: Patricia
authors.initials: P
authors.lastname: Garcia
authors.forename: Juan
authors.initials: J
authors.lastname: Nieto
authors.forename: Daniel
authors.initials: D
authors.lastname: Will
authors.forename: Ronald
authors.initials: R
authors.lastname: Gentile
authors.forename: Thomas
authors.initials: T
authors.lastname: Muldoon
authors.forename: Joseph
authors.initials: J
authors.lastname: Walsh
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Yannuzzi
authors.forename: Yale
authors.initials: Y
authors.lastname: Fisher
authors.forename: Dennis
authors.initials: D
authors.lastname: Orlock
authors.forename: Rishard
authors.initials: R
authors.lastname: Weitz
authors.forename: John A
authors.initials: JA
authors.lastname: Rogers
authors.forename: Shane
authors.initials: S
authors.lastname: Dunne
authors.forename: Aaron
authors.initials: A
authors.lastname: Boxer
mesh_terms: D004867:Equipment Design; D019544:Equipment Failure Analysis; D005240:Feasibility Studies; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000295:instrumentation / Q000379:methods; D018613:Microscopy, Confocal / Q000295:instrumentation* / Q000379:methods*; D019721:Ophthalmoscopes; D009887:Ophthalmoscopy / Q000379:methods*; D010865:Pilot Projects; D012160:Retina / Q000473:pathology*; D012164:Retinal Diseases / Q000473:pathology*; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods*