title: [Determination of individually endurable intraocular pressure (pressure of target) in primary glaucoma].
abstract: On the basis of ocular perfusion pressure a new method was suggested for determining an individually endurable intraocular pressure (IOP), i.e. pressure of target. A total of 390 eyes (232 patients with primary open-angle and normal-tension glaucoma) were examined before and after conservative and surgical treatment. The pressure of target was found, in a progressing worsening of visual functions, to be significantly lower versus the stabilized glaucoma, which was due to a low ocular perfusion pressure. The maximally tolerable IOP in a progressing glaucomatous optic neuropathy concomitant with a normalized IOP amounts to 13-15 mm Hg; while, in the stabilized glaucoma it can exceed the mean statistic norm. The pressure of target was shown to be a non-permanent value, which changes depending on the dynamics of the ophthalmic perfusion pressure and IOP. The sensitivity of the suggested method is 77.4%. It can be used in prognosticating the glaucomatous-process clinical course and in choosing an optimal tactics for the treatment of open-angle and normal-tension glaucoma.
authors.forename: V F
authors.initials: VF
authors.lastname: Shmyreva
authors.forename: O A
authors.initials: OA
authors.lastname: Shmeleva-Demir
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Mazurova
mesh_terms: D005901:Glaucoma / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007429:Intraocular Pressure; D008962:Models, Theoretical; D009901:Optic Nerve Diseases / Q000150:complications / Q000503:physiopathology; D011379:Prognosis; D014065:Tonometry, Ocular