Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract.
Almahmeed
Taghreed
T
Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Boyle
Jay O
JO
Cohen
Erik G
EG
Carew
John F
JF
Du
Baoheng
B
Altorki
Nasser K
NK
Kopelovich
Levy
L
Fang
Jia-Long
JL
Lazarus
Philip
P
Subbaramaiah
Kotha
K
Dannenberg
Andrew J
AJ
D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D001564:Benzo(a)pyrene / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D002460:Cell Line; D051546:Cyclooxygenase 2; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism*; D065633:Cytochrome P-450 CYP1B1; D020719:Glucuronides / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D007972:Leukoplakia, Oral / Q000378:metabolism / Q000473:pathology*; D008565:Membrane Proteins; D009061:Mouth Mucosa / Q000378:metabolism; D009062:Mouth Neoplasms / Q000378:metabolism / Q000473:pathology; D010636:Phenols / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D014059:Tongue / Q000378:metabolism / Q000473:pathology
D020719:Glucuronides; D007527:Isoenzymes; D008565:Membrane Proteins; D010636:Phenols; D001564:Benzo(a)pyrene; D001189:Aryl Hydrocarbon Hydroxylases; C585496:CYP1B1 protein, human; D019363:Cytochrome P-450 CYP1A1; D065633:Cytochrome P-450 CYP1B1; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases