The impact of liver metastasis on mortality in patients initially diagnosed with locally advanced or resectable pancreatic cancer.
BACKGROUND
Liver metastases are frequent in pancreatic cancer, although their impact on patient mortality is still unclear.


METHODS
The extent of liver metastasis (H-III [diffuse], H-II [moderate], H-I [limited], H-0) and the magnitude of liver dysfunction (lf-III [failure], lf-II [severe], lf-I [moderate], lf-0) were reviewed in 89 locally advanced and resectable pancreatic cancer patients in order to determine possible relationships with mortality and survival.


RESULTS
The extent of liver metastasis (H-III, 18; H-II, 20; H-I, 12; H-0, 39) and the magnitude of liver dysfunction (lf-III, 12; lf-II, 8; lf-I, 11; lf-0, 58) were quite variable. Based on the aforementioned two categories, pancreatic cancer patients could be divided into four groups: (A) extensive liver metastasis affecting patient mortality, 14% (12/89); (B) liver metastases that do not cause severe liver dysfunction, 38% (34/89); (C) severe liver dysfunction, not associated with liver metastasis, 9% (8/89); (D) spared liver function, with no liver metastasis, 39% (35/89). The median survival period of H-III patients (195 d) was quite short compared with those of H-I (288 d) and H-0 (240 d) patients.


CONCLUSIONS
Considering patients with locally advanced and resectable pancreatic cancer, the fraction of cases with diffuse liver metastases is relatively small. Moreover, only a minor proportion of pancreatic cancer patients die from hepatic failure as a direct result of liver metastasis.
Nakahashi
Chigusa
C
Hepato-Biliary-Pancreatic Division, National Cancer Center Hospital East, Chiba, Japan.
Oda
Tatsuya
T
Kinoshita
Taira
T
Ueda
Takanori
T
Konishi
Masaru
M
Nakagohri
Toshio
T
Inoue
Kazuto
K
Furuse
Junji
J
Ochiai
Atsushi
A
Ohkohchi
Nobuhiro
N
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000209:etiology / Q000401:mortality* / Q000473:pathology; D008113:Liver Neoplasms / Q000401:mortality* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000401:mortality* / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis