HLA-B27 allele diversity in Indians: impact of ethnic origin and the caste system.
HLA-B27 is a serological specificity which encompasses an increasing number of subtypes that show varied racial/ethnic prevalence in the world. Here, data from 5129 Indians (4500 population and caste; 629 tribal) is compiled from the literature. In addition, HLA-B27 subtyping of 58 positive individuals from Maharastra is presented. Analysis revealed an increased B27 antigen frequency among the north Indian groups (>5%) compared to the south Indian groups (<5%). HLA-B27 subtyping identified B*2704 (34.48%), B*2705 (36.2%), B*2707 (15.51%), B*2708 (10.34%) and B*2714 (3.44%) alleles in the population groups from Maharastra, but these differed in their distribution among the caste and tribal groups studied. The study showed that more extensive subtyping in other Indian caste groups will be necessary to resolve the evolutionary implications of HLA-B27 subtypes and their relationship to disease association in the Indian context.
Shankarkumar
U
U
HLA Department, Institute of Immunohaematology (ICMR), 13th Floor, KEM Hospital, Parel, Mumbai-400012, India. shankarkumar16@hotmail.com
D000483:Alleles; D005006:Ethnicity / Q000235:genetics*; D018703:Founder Effect; D005828:Genetics, Population; D015796:HLA-B27 Antigen / Q000032:analysis* / Q000235:genetics; D006801:Humans; D007194:India; D012923:Social Class
D015796:HLA-B27 Antigen