Expanded chemistry of formamidine ureas.
[reaction: see text] Formamidine ureas display a rich manifold of reactivity. Thiols induce substitution at the carbonyl carbon to give thiolcarbamates; base-mediated alkylation and acylation occurs at the terminal urea nitrogen, and a new fragmentation/acylation pathway has been uncovered with isocyanates.
Díaz
David D
DD
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, California 92037, USA.
Finn
M G
MG