Chlamydia pneumoniae and future risk in patients with coronary heart disease.
OBJECTIVE
To evaluate the association between previous exposure to Chlamydia pneumoniae and future coronary risk in patients with coronary heart disease.


METHODS
A prospective, nested, case-control design was used. The patient sample was derived from a trial study of bezafibrate for the treatment of coronary heart disease. Anti-Chlamydia pneumoniae antibodies (IgG and IgA) in the baseline sera of 136 patients who had coronary events during follow-up (mean 6.2 years) were compared with those in 136 age- and gender-matched patients from the same trial without subsequent coronary events.


RESULTS
Mean titers of IgG and IgA antibodies were similar in cases and controls. The relative odds of future coronary events in patients who were seropositive at baseline were 1.0 (95% CI, 0.54-1.84) for IgG and 0.74 (95% CI, 0.41-1.31) for IgA. The relative odds did not change after adjustment for multiple confounding variables. The risk of future coronary events did not increase with increasing anti-Chlamydia pneumoniae antibody titers.


CONCLUSIONS
Prior exposure to Chlamydia pneumoniae in patients with chronic coronary heart disease is not associated with increased risk of recurrent coronary events.
Haim
Moti
M
Department of Cardiology, Rabin Medical Center, Beilinson Campus, Petah Tiqva 49 100, Israel. motih@netvision.net.il
Tanne
David
D
Battler
Alexander
A
Boyko
Valentina
V
Reshef
Tamar
T
Goldbourt
Uri
U
Brunner
Daniel
D
Mekori
Yoseph A
YA
Behar
Solomon
S
D000907:Antibodies, Bacterial / Q000097:blood; D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000097:blood / Q000150:complications*; D016993:Chlamydophila pneumoniae; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors
D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G