title: Improvement of intestinal motility using S-methylisothiourea in postoperative ileus.
abstract: BACKGROUND
  The inflammatory mediator nitric oxide (NO) plays an important role in postoperative gastrointestinal motility.
  
  
  METHODS
  Using S-methylisothiourea sulfate (SMT), a selective inducible nitric oxide synthase inhibitor, we studied the physiological role of the endogenous NO in the modulation of intestinal motility. The study was performed in vivo in a canine postoperative model. Ten mongrel dogs were treated with a continuous intravenous infusion of SMT after a surgical intestinal manipulation. Small intestine transit time was fluoroscopically measured using barium sulfate as it passed through a gastrostomy tube on postoperative days (POD) 1, 2, and 3.
  
  
  RESULTS
  Average transit times on POD 1 in the 4 mg/kg/h and 2 mg/kg/h SMT groups significantly decreased compared with that of the saline group. However, the transit times on POD 2 and 3 were not significantly different among the three groups.
  
  
  CONCLUSIONS
  S-methylisothiourea sulfate improves small intestine motility at an early postoperative stage.
authors.affiliation: First Department of Surgery, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan. sue@hama-med.ac.jp
authors.forename: Shouiti
authors.initials: S
authors.lastname: Uenoyama
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Yamashita
authors.forename: Yukio
authors.initials: Y
authors.lastname: Koide
authors.forename: Teruhisa
authors.initials: T
authors.lastname: Kazui
mesh_terms: D000818:Animals; D004285:Dogs; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D045823:Ileus / Q000209:etiology*; D007550:Isothiuronium / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy*
chemical_list: D004791:Enzyme Inhibitors; D007550:Isothiuronium; C027744:S-methylisothiopseudouronium