title: Synthesis, characterization and biological activity of Ni, Cu and Zn complexes of isatin hydrazones.
abstract: Nickel, copper, and zinc complexes of isatin (H(2)L(1)) and N-methylisatin 3-picolinoyl hydrazone (HL(2)), were synthesized and characterized by means of spectroscopic techniques. H(2)L(1) and a nickel complex [Ni(L(2))(2)].2C(6)H(14) were also characterized by X-ray diffractometry. Biological studies, carried out in vitro on human leukemic cell lines TOM 1 and NB4, have shown that both ligands and some copper and nickel complexes are active in inhibiting cell proliferation. Compounds H(2)L(1), Cu(HL(1))(2).2H(2)O, Zn(HL(1))(2).2H(2)O inhibit DNA synthesis and act constantly with time between 0 and 72 h. The cell cycle analysis has highlighted a reduction in the number of cells in phase S of about 40%. The same compounds present only a precocious action on cell line NB4 and therefore their activity is cell target specific.
authors.affiliation: Departamento de Quíica Inorgánica, Universidade de Vigo, 36200 Vigo, Spain.
authors.forename: Maria C
authors.initials: MC
authors.lastname: Rodríuez-Argüelles
authors.forename: Marisa
authors.initials: M
authors.lastname: Belicchi errari
authors.forename: Franco
authors.initials: F
authors.lastname: Bisceglie
authors.forename: Corrado
authors.initials: C
authors.lastname: Pelizzi
authors.forename: Giorgio
authors.initials: G
authors.lastname: Pelosi
authors.forename: Silvana
authors.initials: S
authors.lastname: Pinelli
authors.forename: Monica
authors.initials: M
authors.lastname: Sassi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis; D002453:Cell Cycle; D045744:Cell Line, Tumor; D003300:Copper / Q000378:metabolism; D018360:Crystallography, X-Ray; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism*; D007510:Isatin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D007938:Leukemia / Q000628:therapy; D019216:Metals, Heavy / Q000737:chemistry* / Q000378:metabolism; D009532:Nickel / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D015032:Zinc / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D006835:Hydrazones; D019216:Metals, Heavy; C490228:N-methylisatin 3-picolinoyl hydrazone; C490229:isatin 3-picolinoyl hydrazone; D003300:Copper; D009532:Nickel; D007510:Isatin; D015032:Zinc