title: Induction treatment before surgery for non-small cell lung cancer.
abstract: Surgery alone is currently still accepted "standard of care" for patients with operable NSCLC, this includes stages IA and IIB, as well as selected early subsets of IIIA disease. In more advanced and inoperable stage III disease, combinations of chemotherapy and radiotherapy remain the standard treatment approach for patients with good performance status. The role of surgery following induction therapy in these advanced stage III patients is at the moment not conclusively defined. More evidence from randomized trials is clearly needed to tailor treatment for the large number of patients that present in these locally advanced stages. Enrollment of patients into ongoing prospective clinical trials should be encouraged, whenever possible, to further define prognostic factors and improve multimodality strategies in this clinical setting.
authors.affiliation: Department of Internal Medicine, Cancer Research, West German Cancer Center, Medical School of the Duisburg-Essen University. wilfried.eberhardt@uni-essen.de
authors.forename: W E
authors.initials: WE
authors.lastname: Eberhardt
authors.forename: K S
authors.initials: KS
authors.lastname: Albain
authors.forename: H
authors.initials: H
authors.lastname: Pass
authors.forename: J B
authors.initials: JB
authors.lastname: Putnam
authors.forename: A
authors.initials: A
authors.lastname: Gregor
authors.forename: H
authors.initials: H
authors.lastname: Assamura
authors.forename: F
authors.initials: F
authors.lastname: Mornex
authors.forename: S
authors.initials: S
authors.lastname: Senan
authors.forename: J
authors.initials: J
authors.lastname: Belderbos
authors.forename: V
authors.initials: V
authors.lastname: Westeel
authors.forename: M
authors.initials: M
authors.lastname: Thomas
authors.forename: P
authors.initials: P
authors.lastname: Van Schil
authors.forename: J
authors.initials: J
authors.lastname: Vansteenkiste
authors.forename: C
authors.initials: C
authors.lastname: Manegold
authors.forename: R O
authors.initials: RO
authors.lastname: Mirimanoff
authors.forename: M
authors.initials: M
authors.lastname: Stuschke
authors.forename: J
authors.initials: J
authors.lastname: Pignon
authors.forename: P
authors.initials: P
authors.lastname: Rocmans
authors.forename: F A
authors.initials: FA
authors.lastname: Shepherd
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D004334:Drug Administration Schedule; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic