Gemcitabine plus radiation therapy in the treatment of locally advanced non small-cell lung cancer.
For stage III non small-cell lung cancer, there is a need for better systemic, as well as locoregional, control of the tumor. In an attempt to enhance this locoregional control, systemic chemotherapy has been given currently with radiation therapy. Gemcitabine, a novel deoxycytidine analogue, has been shown to be a potent radiosensitizer. This review focuses on the studies using gemcitabine concurrently with radiation therapy in the treatment of locally advanced non small-cell lung cancer.
Ettinger
D S
DS
Johns Hopkins Oncology Center, Baltimore, Maryland, USA. ettinda@uhmi.edu