Molecular regulation of cardiac chamber-specific gene expression.
This review focuses on recent studies investigating the genetic regulatory mechanisms leading to formation of morphologically, functionally, and molecularly distinct cardiac chambers. The regulation of four representative chamber-specific genes that have been studied in detail is reviewed. These genes include the atrial-specific genes, myosin light chain-2a (MLC2a), slow myosin heavy chain-3 (slow MyHC3), and atrial natriuretic factor (ANF) and the ventricular specific gene, myosin light chain-2v (MLC2v). Comparison of these promoters reveals some generalizations about the regulatory mechanisms involved in chamber-specific gene expression but, equally, indicates the large gaps in the knowledge concerning this intriguing genetic program.
Small
Eric M
EM
Department of Cell Biology and Anatomy, University of Arizona Health Sciences Center, 1501 N. Campbell Avenue, Tucson, AZ 85724-5044, USA.
Krieg
Paul A
PA
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics*; D009202:Cardiomyopathies / Q000235:genetics*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology*; D006801:Humans; D008297:Male; D008967:Molecular Biology; D018995:Myosin Heavy Chains / Q000235:genetics*; D018994:Myosin Light Chains / Q000235:genetics*; D012680:Sensitivity and Specificity
D018994:Myosin Light Chains; D009320:Atrial Natriuretic Factor; D018995:Myosin Heavy Chains