title: Radiotherapy for muscle-invasive urinary bladder cancer in elderly patients.
abstract: OBJECTIVE
  To review retrospectively the outcome and toxicity of Radiotherapy (RT) in the cohort of elderly patients (EP) with muscle-invasive urinary bladder carcinoma (MIUBC).
  
  
  METHODS
  Thirty-six EP were treated with RT with radical intent. The age of the cohort ranged from 71 to 89 years with a median of 79 years. Eighty percent of the patients had Easter Cooperative Oncology Group (ECOG) 0 and 1 performance status. Conventional and accelerated fractionation RT regimen were utilized.
  
  
  RESULTS
  With median follow up of 45.8 months, the median survival was 23.9 months. There was a trend toward better survival in patients treated with the accelerated fractionation regimen. The median survival for that group (12) has not yet been reached, where it is 9.7 months for the group (24) treated with conventional fractionation. Treatment related toxicity was low for any RT regimens.
  
  
  CONCLUSIONS
  RT is well tolerated by EP with good baseline performance status. The role of accelerated fractionation should be tested by conducting randomized trials.
authors.affiliation: BC Cancer Agency, Fraser Valley Cancer Centre, Surrey, British Columbia, Canada.
authors.forename: Alexander
authors.initials: A
authors.lastname: Agranovich
authors.forename: Piotr
authors.initials: P
authors.lastname: Czaykowski
authors.forename: David
authors.initials: D
authors.lastname: Hui
authors.forename: Tom
authors.initials: T
authors.lastname: Pickles
authors.forename: Winkle
authors.initials: W
authors.lastname: Kwan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000532:radiotherapy*