Relationship between body composition and bone mineral density in healthy young and premenopausal Chinese women.
This study investigated the relative contribution of fat mass and lean mass to bone mineral density (BMD) in young and premenopausal healthy Chinese women. The study was performed in 282 young and premenopausal healthy women with regular menstrual cycles. The BMD at lumbar spine (L2-L4), total hip and total body, together with fat mass and lean mass were assessed by dual-energy X-ray absorptiometry (DXA); body height, weight, waist and hip circumference were also measured, and body mass index (BMI) and waist-hip ratio were calculated. Fat mass was a major determinant for BMI, BMI and lean mass were positively related to L2-L4, total hip and total body bone density ( P<0.001 for all), lean mass was the only independent factor contributing to BMD at L2-L4 (standardized coefficient beta=0.282, P<0.001), total hip (beta=0.336, P<0.001) and total body (beta=0.361, P<0.001) in multiple stepwise regression analysis. The correlation between BMI and BMD was improved after adjustment for fat mass, while decreased or even lost when lean mass was adjusted. These data suggested that in the Chinese population, lean mass is an important factor determining BMD in young and premenopausal women.
Liu
Jian-Min
JM
Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Second Medical University, Shanghai, China. ljmhh@public7.sta.net.cn
Zhao
Hong-Yan
HY
Ning
Guang
G
Zhao
Yong-Ju
YJ
Zhang
Lian-Zhen
LZ
Sun
Li-Hao
LH
Xu
Man-Yin
MY
Chen
Jia-Lun
JL
D015502:Absorptiometry, Photon; D000328:Adult; D000367:Age Factors; D001823:Body Composition; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D015519:Bone Density; D002681:China; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000503:physiopathology; D012044:Regression Analysis