title: [Clinical benefit of bronchial arterial infusion chemotherapy to pulmonary metastasis from colorectal cancer--report of two cases].
abstract: Case 1: A 60-year-old woman with sigmoid colon cancer and multiple lung metastases developed dyspnea 34 months after sigmoidectomy and following systemic chemotherapy. Chest X-ray revealed left atelectasis and obstruction of the left main bronchus by lung metastasis, and stenosis of the right main bronchus was also suspected. Bronchial arterial infusion of CDDP, 5-FU and MMC relieved the atelectasis and dyspnea. The left bronchus remained patent for 12 months. Case 2: A 70-year-old man who had a pulmonary recurrence of rectal cancer suffered from hemoptysis and dyspnea, which had improved with systemic chemotherapy but then become exacerbated again. Bronchoscopic examination revealed intraluminal bleeding from a metastatic tumor. The symptoms were relieved after bronchial arterial infusion of CDDP, 5-FU and MMC. The diameter of the treated tumor was reduced by 15%. Hemoptysis was negligible until he died 8 months later. Bronchial arterial infusion chemotherapy for pulmonary metastasis from colorectal cancer is clinically beneficial, especially for patients with life-threatening respiratory symptoms like airway obstruction or intraluminal bleeding.
authors.affiliation: Dept. of Surgery, Osaka Red Cross Hospital.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kitai
authors.forename: Akinari
authors.initials: A
authors.lastname: Nomura
authors.forename: Akira
authors.initials: A
authors.lastname: Miki
authors.forename: Minoru
authors.initials: M
authors.lastname: Ukikusa
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Kojima
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nishikawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishigaki
authors.forename: Giro
authors.initials: G
authors.lastname: Todo
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001981:Bronchial Arteries; D002945:Cisplatin / Q000008:administration & dosage; D015179:Colorectal Neoplasms / Q000473:pathology*; D004334:Drug Administration Schedule; D004417:Dyspnea / Q000209:etiology; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006469:Hemoptysis / Q000209:etiology; D006801:Humans; D007261:Infusions, Intra-Arterial; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D001261:Pulmonary Atelectasis / Q000209:etiology; D012811:Sigmoid Neoplasms / Q000473:pathology / Q000601:surgery
chemical_list: D016685:Mitomycin; D002945:Cisplatin; D005472:Fluorouracil