Secretory activity of mast cell during stress: effect of prolyl-glycyl-proline and Semax.
Stress increased secretory activity of mast cells in the mesentery and subcutaneous fat of rats. Intraperitoneal injection of Semax and prolyl-glycyl-proline in doses of 0.05 and 1 mg/kg, respectively, 1 h before stress abolished this effect. The test preparations did not modulate secretory activity of mast cells in unstressed animals. Semax and prolyl-glycyl-proline in vitro prevented activation of mast cells with synacten and acetylcholine. The stabilizing effect of peptides on mast cells probably determines their antiulcer activity.
Umarova
B A
BA
Department of Human and Animal Physiology, Biological Faculty, M V Lomonosov Moscow State University.
Kopylova
G N
GN
Smirnova
E A
EA
Guseva
A A
AA
Zhuikova
S E
SE
D000109:Acetylcholine / Q000378:metabolism; D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D021461:Animals, Outbred Strains; D004195:Disease Models, Animal; D007274:Injections, Intraperitoneal; D008297:Male; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D008643:Mesentery / Q000166:cytology / Q000187:drug effects / Q000503:physiopathology; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D011392:Proline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D013315:Stress, Psychological / Q000139:chemically induced* / Q000503:physiopathology
D009842:Oligopeptides; D010446:Peptide Fragments; C113164:prolyl-glycyl-proline; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone; D011392:Proline; D000109:Acetylcholine