Suppression of postoperative systemic inflammatory response syndrome with clarithromycin following lung cancer surgery.
We examined whether clarithromycin (CAM), a 14-membered macrolide, can control the postoperative systemic inflammatory response syndrome that occurs following lung cancer surgery. In the control group (n = 16), prophylactic antibiotics (flomoxef) were administered for 4-7 days following surgery. In the CAM group (n = 10), 400 mg/day of CAM were administered orally for 14 days prior to surgery and for 7 days following surgery, in addition to the postoperative administration of flomoxef. The incidence and duration of the systemic inflammatory response syndrome in the CAM group (30%, 0.3 days) were significantly lower than those in the control group (81%, 1.6 days). There were no significant differences between the control and CAM groups in both the amount and frequency of nonsteroidal anti-inflammatory drugs following surgery. In conclusion, our study suggests that CAM may suppress the postoperative systemic inflammatory response syndrome in lung cancer patients.
Hirata
T
T
Department of Thoracic Surgery, Kishiwada City Hospital, Kishiwada, Osaka, Japan. kch-16@kch.city.kishiwada.osaka.jp
Ogawa
E
E
Takenaka
K
K
Kawashita
F
F
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D016063:Blood Loss, Surgical; D002511:Cephalosporins / Q000627:therapeutic use; D017291:Clarithromycin / Q000627:therapeutic use*; D004322:Drainage; D005260:Female; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications; D011300:Preoperative Care; D013510:Pulmonary Surgical Procedures / Q000009:adverse effects*; D018746:Systemic Inflammatory Response Syndrome / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002511:Cephalosporins; D017291:Clarithromycin; C045693:flomoxef