Highly accurate nephelometric titrimetry.
A method that accurately indicates the end-point of precipitation reactions by the measurement of the relative intensity of the scattered light in the titrate is presented. A new nephelometric titrator with an internal nephelometric sensor has been devised. The work of the titrator including the sensor and change in the turbidity of the titrate and intensity of the scattered light are described. The accuracy of the nephelometric titrimetry is discussed theoretically. The titration of NaCl with AgNO(3) serves as a model. A relative error as well as deviation is within 0.2% under the experimental conditions. The applicability of the titrimetry in pharmaceutical analyses, for example, phenytoin sodium and procaine hydrochloride, is generally illustrated.
Zhan
Xiancheng
X
School of Pharmacy, West China Medical Center, Sichuan University, No. 17, Block 3, Ren-Min-Nan-Lu Road, Chengdu, Sichuan 610041, People's Republic of China. xczhan@mail.sc.cninfo.net
Li
Chengrong
C
Li
Zhiyi
Z
Yang
Xiucen
X
Zhong
Shuguang
S
Yi
Tao
T
D002626:Chemistry, Pharmaceutical; D002840:Chromates / Q000737:chemistry; D003198:Computer Simulation; D019793:Fluorescein; D007202:Indicators and Reagents; D008027:Light; D009391:Nephelometry and Turbidimetry / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis; D010672:Phenytoin / Q000032:analysis; D017680:Potassium Compounds / Q000737:chemistry; D011343:Procaine / Q000032:analysis; D012542:Scattering, Radiation; D012835:Silver Nitrate / Q000032:analysis; D012965:Sodium Chloride / Q000032:analysis
D002840:Chromates; D007202:Indicators and Reagents; D004364:Pharmaceutical Preparations; D017680:Potassium Compounds; D012965:Sodium Chloride; D011343:Procaine; C027373:potassium chromate(VI); D010672:Phenytoin; D012835:Silver Nitrate; D019793:Fluorescein