Immunoglobulin heavy chain genes somatic hypermutations and chromosome 11q22-23 deletion in classic mantle cell lymphoma: a study of the Swiss Group for Clinical Cancer Research.
Mantle cell lymphoma (MCL) shares immunophenotypic and karyotypic features with chronic lymphocytic leukaemia. The latter comprises two distinct entities with prognosis dependent upon immunoglobulin heavy chain (IgH) gene mutational status and the presence of 11q deletion. We evaluated the relevance of IgH gene mutational status, IgV gene family usage and presence of 11q deletion in a series of 42 histologically reviewed classical MCL cases to determine the prognostic impact. VH3 was the most common VH family, with VH3-21 being the most frequent individual VH gene. Approximately 30% of the cases had a IgH somatic mutation rate higher than 2%, but was only higher than 4% in <10% of cases. Half of the cases had deletion of chromosome 11q21-telomere (11q21->ter), with two minimal deleted regions, at 11q22.2 and 11q23.2. There was no association between 11q loss and IgH gene somatic mutation rate; the use of VH3-21 gene could be associated with a better prognosis.
Bertoni
Francesco
F
Experimental Oncology, Oncology Institute of Southern Switzerland, Via Vincenzo Vela 6, Stabile IRB, 6500 Bellinzona, Switzerland. frbertoni@mac.com
Conconi
Annarita
A
Cogliatti
Sergio B
SB
Schmitz
Shu-Fang Hsu
SF
Ghielmini
Michele
M
Cerny
Thomas
T
Fey
Martin
M
Pichert
Gabriella
G
Bertolini
Francesco
F
Ponzoni
Maurilio
M
Baldini
Luca
L
Jones
Chris
C
Auer
Rebecca
R
Zucca
Emanuele
E
Cavalli
Franco
F
Cotter
Finbarr E
FE
D000368:Aged; D002880:Chromosomes, Human, Pair 11; D005260:Female; D017353:Gene Deletion; D005803:Genes, Immunoglobulin; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011379:Prognosis