Design and synthesis of a series of chlorinated 3-deazaadenine analogues.
A series of chlorinated adenine analogues were designed with sights set on the development of potential antitumor agents. During the synthetic efforts, two unexpected compounds were identified. Their synthesis, along with synthesis of the chlorinated targets is presented herein.
Seley
Katherine L
KL
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia, USA. kseley@umbc.edu
O'Daniel
Peter I
PI
Salim
Samer
S
D000225:Adenine / Q000031:analogs & derivatives* / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D002713:Chlorine / Q000737:chemistry; D015195:Drug Design; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry
D000970:Antineoplastic Agents; D011687:Purines; D002713:Chlorine; C055133:3-deazaadenine; D000225:Adenine