Understanding the cortex of crawling cells: insights from Dictyostelium.
All animal cells are believed to use the same basic molecular mechanisms for locomotion when crawling on a surface. Study of a wide range of crawling cells has tended to confirm this belief but has also led to a diversity of hypotheses for locomotion and a bewildering list of candidate effector proteins. The emergence of a powerful model system, Dictyostelium discoideum, for the study of crawling of cells makes definitive tests of hypotheses for locomotion a reality.
Condeelis
J
J
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.