title: Linkage of the locus for canine dewclaw to chromosome 16.
abstract: The canine species, including wolf and jackal, have four digits on the hind limb. It was thought that an extra first digit on the hind limb, named dewclaw, was a hereditary defect. For genetically related canine pedigrees with 73 members with dewclaws, we carried out a genome-wide scan for linkage with microsatellites. With an assumption of autosomal dominant mode of inheritance, significant linkages were detected for the markers on canine chromosome 16. The maximum two-point lod score of 20.76 was obtained for the REN85M08/REN85N14 markers at a recombination fraction of 0.00. For efficient analysis of linkage, a revised order of the chromosomal markers was established by assigning all the existing markers from the previous linkage and radiation hybrid maps. A chromosome-wide haplotype analysis revealed the location of the dewclaw locus within a few centimorgan intervals delimited by the UCMCF12 and CXX876 markers. Canine chromosome 16 is known to have syntenic relationships with human chromosomes 4q, 7q, and 8p.
authors.affiliation: National Creative Research Initiative Center for Behavioral Genetics, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong-gu Taejon 305-701, South Korea.
authors.forename: Kiyun
authors.initials: K
authors.lastname: Park
authors.forename: Joohyun
authors.initials: J
authors.lastname: Kang
authors.forename: Sangjin
authors.initials: S
authors.lastname: Park
authors.forename: Jihong
authors.initials: J
authors.lastname: Ha
authors.forename: Chankyu
authors.initials: C
authors.lastname: Park
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes; D000013:Congenital Abnormalities / Q000235:genetics; D004285:Dogs / Q000235:genetics*; D005529:Foot Bones / Q000002:abnormalities*; D008040:Genetic Linkage; D005819:Genetic Markers; D006239:Haplotypes; D008126:Lod Score; D010375:Pedigree; D011995:Recombination, Genetic
chemical_list: D005819:Genetic Markers