Activity of neutrophil NADPH oxidase in iron-deficient anemia.
This study was designed to measure the effects of iron supplementation on respiratory burst in iron-deficient anemia. The performance of neutrophils was evaluated by measuring the activity of NADPH oxidase in 18 patients with iron-deficient anemia before and after body iron stores are saturated. The activity of NADPH oxidase was significantly lower in pretreatment patients relative to controls (p<0.05). The activity increased after iron supplementation to levels that had no significant differences relative to controls.
Kurtoglu
Erdal
E
Department of Hematology, Medical School, Selcuk University, Konya, Turkey.
Ugur
Aysegul
A
Baltaci
Abdulkerim Kasim
AK
Mogolkoc
Rasim
R
Undar
Levent
L
D018798:Anemia, Iron-Deficiency / Q000201:enzymology* / Q000276:immunology; D001770:Blood Bactericidal Activity / Q000276:immunology; D019587:Dietary Supplements; D006801:Humans; D007501:Iron / Q000008:administration & dosage / Q000494:pharmacology; D019255:NADPH Oxidases / Q000378:metabolism*; D009504:Neutrophils / Q000201:enzymology*; D010587:Phagocytosis / Q000276:immunology; D013050:Spectrometry, Fluorescence; D018709:Statistics, Nonparametric
D007501:Iron; D019255:NADPH Oxidases