Effects of multivitamin and folic acid supplementation in malnourished children.
OBJECTIVE
To study the effect of multivitamin and folic acid supplementation on serum folate level and weight gain.


METHODS
A prospective randomized controlled study was conducted in malnourished children at the Nutrition Clinic, Queen Sirikit National Institute of Child Health from February to June 2000. History taking, weight-height measurement, and blood testing for complete blood count (CBC) and serum folate level were done. Patients were randomly by assigned into 2 groups. The study group was supplemented daily with multivitamins (MVD) along with a folic acid tablet while the control group was supplemented daily with MVD only, for 6 weeks.


RESULTS
Twenty-nine malnourished children were enrolled in the present study. They were randomly by assigned into 2 groups, 14 children in the study group and 15 children in the control group. There were 11 boys (38%) and 18 girls (62%). Mean age was 36.3 months. Anemia and low serum folate level were found in 24 per cent and 21 per cent respectively. There was no significant difference in the data of both groups, except that anemia was more common in the study group (p = 0.018). After 6 weeks of supplementation, increases in weight and serum folate level were significantly higher in the study group, but there was no significant difference in weight increased between both groups.


CONCLUSIONS
Folate deficiency may be found in malnourished children. Efficacy of folic acid supplement is good. Folic acid needs to be supplemented in malnourished children.
Ratanachu-Ek
Suntaree
S
Gastroenterology and Nutrition Unit, Department of Pediatrics, Queen Sirikit National Institute of Child Health, Bangkok 10400, Thailand.
D016009:Chi-Square Distribution; D002675:Child, Preschool; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D008297:Male; D044342:Malnutrition / Q000188:drug therapy*; D011446:Prospective Studies; D016896:Treatment Outcome; D014815:Vitamins / Q000008:administration & dosage*; D015430:Weight Gain
D014815:Vitamins; D005492:Folic Acid