Mouse models to study G-protein-mediated signaling.
The G-protein-mediated signaling system has evolved as one of the most widely used transmembrane signaling mechanisms in eukaryotic organisms. Mammalian cells express many G-protein-coupled receptors as well as several types of heterotrimeric G-proteins and effectors. This review focuses on recent data from studies in mutant mice, which have elucidated some of the roles of G-protein-mediated signaling in physiology and pathophysiology.
Wettschureck
Nina
N
Institute of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg, Germany. Nina.Wettschureck@urz.uni-heidelberg.de
Moers
Alexandra
A
Offermanns
Stefan
S
D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D004703:Endocrine System / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology*; D007107:Immune System / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D009424:Nervous System Physiological Phenomena; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D043562:Receptors, G-Protein-Coupled; D019204:GTP-Binding Proteins