Overexpression of the BCL2 gene in a Sertoli-Leydig cell tumor of the ovary: a pathologic and cytogenetic study.
A case of virilizing ovarian Sertoli-Leydig cell tumor overexpressing the BCL2 gene and including a novel clonal chromosomal rearrangement of chromosome 18, der(5)t(5;18)(p13;q12),+6,+12, der(18)r(5;18)(p15.3p13;p11.3q12) is described. Further studies of these rare tumors are necessary to ascertain the significance of the findings.
Truss
Lisa
L
Scott, Sherwood and Brindley Foundation, The Texas A and M University System Health Science Center, College of Medicine, 2401 South 31st Street, Temple, TX 76508, USA.
Dobin
Sheila M
SM
Rao
Arundati
A
Donner
Ludvik R
LR
D000293:Adolescent; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis / Q000235:genetics*; D018310:Sertoli-Leydig Cell Tumor / Q000235:genetics* / Q000473:pathology
D019253:Proto-Oncogene Proteins c-bcl-2