HLA genotyping in type-I autoimmune hepatitis in Western India.
OBJECTIVE
To analyze association of different HLA genotypes for predisposition to type-I autoimmune hepatitis in Western India.


METHODS
This study was undertaken on patients of type-I autoimmune hepatitis (defined by international criteria by IAHG, 1999). HLA genotyping for class I and II was done in 20 patients of autoimmune hepatitis and 100 healthy controls. Statistics were done using Halden's modification of Woolfs formula.


RESULTS
Significant association of autoimmune hepatitis was found amongst class I antigens--HLA B27 [20 vs. 0 %] & HLA cw4 [40 vs. 15 %] and amongst class II antigens--DRBI*01XX [25 vs. 2%], DRB1*14XX [30 vs. 12%], DRB1*15XX [40 vs. 25%] and DRB1*07XX [20 vs. 9 %] at DRB1 locus. Stronger association was found with HLA B27, cw4 & HLA DRB1 *01XX.


CONCLUSIONS
Our data indicate that predisposition to autoimmune hepatitis is different in Indian patients and not associated with HLA DRB1*03XX or *04XX, as seen in Western world.
Amarapurkar
D N
DN
Department of Gastroenterology, Bombay Hospital and Medical Research Center, Mumbai.
Patel
N D
ND
Amarapurkar
Anjali D
AD
Kankonkar
S R
SR
D000293:Adolescent; D000328:Adult; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D019693:Hepatitis, Autoimmune / Q000235:genetics*; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged
D006680:HLA Antigens