Heat-shock proteins maintain the viability of ATP-deprived cells: what is the mechanism?
ATP depletion causes necrosis in mammalian cells. However, a previous heat shock can protect cells from the effects of energy deprivation, probably as a result of the synthesis and accumulation of heat-shock proteins (hsps). We propose that hsps protect ATP-depleted cells from rapid necrotic death by inhibiting the aggregation of cytoskeletal proteins that occurs when ATP synthesis is blocked.
Kabakov
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AE
Department of Radiation Biochemistry, Medical Radiology Research Center, 4 Korolev St, Obninsk 249020, Russia.
Gabai
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VL