title: Genetic determinants of osteoporosis susceptibility in a female Ashkenazi Jewish population.
abstract: OBJECTIVE
  To determine the heritability of low bone mineral density (BMD) at the hip in Ashkenazi Jewish families.
  
  
  METHODS
  BMD at hip was accessed by dual x-ray absorptiometry (DEXA) in 166 female subjects from 61 families. Variance component analysis was used to estimate genetic contributions.
  
  
  RESULTS
  We observed significant genetic contributions to age-adjusted BMD at the femoral neck as measured by heritability 0.67 (P < 0.0001).
  
  
  CONCLUSIONS
  There is significant genetic determination in decreased BMD at the femoral neck in an Ashkenazi Jewish female population. These results warrant further gene mapping studies in this population to identify osteoporosis susceptibility loci.
authors.affiliation: Burns and Allen Research Institute and Divisions of Medical Genetics and Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center and University of California, Los Angeles, California, USA.
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Li
authors.forename: Sako
authors.initials: S
authors.lastname: Chen
authors.forename: Vitaly
authors.initials: V
authors.lastname: Kantorovich
authors.forename: Li S C
authors.initials: LS
authors.lastname: Cheng
authors.forename: Dan H
authors.initials: DH
authors.lastname: Cohn
authors.forename: Jerome I
authors.initials: JI
authors.lastname: Rotter
authors.forename: Huiying
authors.initials: H
authors.lastname: Yang
authors.forename: John S
authors.initials: JS
authors.lastname: Adams
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density / Q000235:genetics*; D005260:Female; D005269:Femur; D020022:Genetic Predisposition to Disease; D006801:Humans; D040582:Inheritance Patterns; D007585:Jews / Q000235:genetics*; D008875:Middle Aged; D010024:Osteoporosis / Q000208:ethnology* / Q000235:genetics*; D010375:Pedigree