Association between apolipoprotein CI HpaI polymorphism and sporadic Alzheimer's disease in Chinese.
OBJECTIVE
To investigate into the relationship of apolipoprotein CI (ApoCI) polymorphism with sporadic Alzheimer's disease (AD) in Chinese.


METHODS
A total of 257 AD patients and 242 age-matched elderly individuals were genotyped for the ApoCI HpaI and apolipoprotein E (ApoE) HhaI polymorphisms.


RESULTS
The ApoCI A allele was associated with AD of moderate to severe dementia when patients were divided into two subgroups according to Clinical Dementia Rating scale, and the AA genotype was strongly associated with moderate to severe AD in ApoE epsilon4 allele carriers [odds ratio (OR) = 8.19, 95% confidential interval: 1.28-52.30, after adjusting for age and gender by logistic regression analysis], although in total no significant differences of allele or genotype frequency between patients and controls were found.


CONCLUSIONS
The present study partially confirmed the previous findings, suggesting that the ApoCI A allele might contribute to the susceptibility to moderate to severe sporadic AD in Chinese.
Shi
J
J
Department of Medical Genetics, West China Hospital, Sichuan University, Chengdu, China.
Zhang
S
S
Ma
C
C
Liu
X
X
Li
T
T
Tang
M
M
Han
H
H
Guo
Y
Y
Zhao
J
J
Zheng
K
K
Kong
X
X
Zhang
K
K
Su
Z
Z
Zhao
Z
Z
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D053302:Apolipoprotein C-I; D001056:Apolipoproteins C / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012720:Severity of Illness Index
D053302:Apolipoprotein C-I; D001056:Apolipoproteins C