Venlafaxine-induced depression of wind-up activity in mononeuropathic rats is potentiated by inhibition of brain 5-HT1A receptor expression in vivo.
Antinociceptive effects of inhibiting 5-HT1A receptor expression by intracerebroventricular administration of an antisense oligodeoxynucleotide were studied in mononeuropathic rats. A 7-day period of treatment with the antisense produced: (i) reduction of mechanical hyperalgesia in the neuropathic hindlimb starting from day 5 of treatment, (ii) decrease of the hypothermic effect of 8-OH-DPAT challenge on day 6 of treatment, and (iii) potentiation of the inhibitory effect of velafaxine on spinal wind-up activity on day 7 of treatment. Results suggest a counteracting role of somatodendritic 5-HT1A receptors of raphe nuclei neurons in the antinociceptive efficacy of antidepressants with serotonergic spectrum in neuropathic pain.
Hernández
Alejandro
A
Faculty of Chemistry and Biology, University of Santiago of Chile, Santiago, Chile. ahernand@lauca.usach.ed
Constandil
Luis
L
Laurido
Claudio
C
Pelissier
Teresa
T
Marchand
Fabien
F
Ardid
Denis
D
Alloui
Abdelkrim
A
Eschalier
Alain
A
Soto-Moyano
Rubén
R
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D001831:Body Temperature / Q000187:drug effects; D003511:Cyclohexanols; D003863:Depression / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy; D006930:Hyperalgesia / Q000188:drug therapy* / Q000209:etiology; D015918:Infusion Pumps, Implantable; D008297:Male; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use*; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics; D012018:Reflex / Q000187:drug effects; D012043:Regression, Psychology; D020426:Sciatic Neuropathy / Q000139:chemically induced / Q000188:drug therapy*; D058829:Serotonin 5-HT1 Receptor Antagonists; D017367:Selective Serotonin Reuptake Inhibitors; D013997:Time Factors; D000069470:Venlafaxine Hydrochloride
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D003511:Cyclohexanols; D016376:Oligonucleotides, Antisense; D044282:Receptor, Serotonin, 5-HT1A; D058829:Serotonin 5-HT1 Receptor Antagonists; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride