title: Effects of margarine containing medium-chain triacylglycerols on body fat reduction in humans.
abstract: We found previously that the ingestion of margarine containing medium-chain triacylglycerols (MCT) resulted in a significant increase in postprandial thermogenesis when compared with long-chain triacylglycerols (LCT). Diets that included margarine containing MCT and LCT were compared for 12 weeks in 73 subjects to investigate the effects on body weight, body fat, areas of subcutaneous and visceral fat, serum total cholesterols, triglycerides, lipoproteins, plasma glucose, serum insulin, total ketone bodies, and the activities of aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyltranspeptidase. We conducted a double-blind, controlled study and used blended rapeseed oil and soybean oil (LCT) as a comparison. Two groups ingested 2100-2400 kcal/day of energy, 65-73 g/day of total fat, and 14 g/day of test margarine (5 g/day of MCT or LCT). The subjects on the MCT diet demonstrated significant decreases in body fat weight (- 3.8 +/- 2.4 kg vs - 2.4 +/- 1.7 kg; MCT vs LCT, mean +/- SD), subcutaneous fat (- 38.2 +/- 29.9 cm(2) vs - 22.6 +/- 19.3 cm(2)), and visceral fat (- 12.2 +/- 11.2 cm(2) vs - 1.6 +/- 12.8 cm(2)) after 12 weeks. There were no clinical differences in measured blood parameters. We suggest that the postprandial increase in thermogenesis and control of postprandial triglyceride levels may explain these results.
authors.affiliation: Division of Healthcare Science, Research Laboratory, The Nisshin Oillio, Ltd, Kanagawa, Japan. n-nosaka@nisshin.olliogroup.com
authors.forename: Naohisa
authors.initials: N
authors.lastname: Nosaka
authors.forename: Hideaki
authors.initials: H
authors.lastname: Maki
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Haruna
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ohara
authors.forename: Michio
authors.initials: M
authors.lastname: Kasai
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tsuji
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Aoyama
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Okazaki
authors.forename: Osamu
authors.initials: O
authors.lastname: Igarashi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kondo
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology*; D000328:Adult; D001786:Blood Glucose; D001823:Body Composition; D001827:Body Height; D001835:Body Weight; D004435:Eating; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007657:Ketone Bodies / Q000097:blood; D008297:Male; D008383:Margarine; D008875:Middle Aged; D018673:Nutrition Policy; D019518:Postprandial Period; D040521:Subcutaneous Tissue; D014280:Triglycerides / Q000008:administration & dosage*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D007657:Ketone Bodies; D014280:Triglycerides; D008383:Margarine