Non-T-cell-depleted HLA-haploidentical hematopoietic stem cell transplantation from a family donor based on fetomaternal microchimerism in pediatric hematologic malignancies.
Based on recent fetomaternal microchimerism/tolerance theory, two children with acute lymphoblastic leukemia underwent non-T-cell-depleted hematopoietic stem cell transplants (SCT) from haploidentical HLA 2 loci-mismatched family donors (one from a sibling, one from the mother). Engraftment was achieved in two patients. In two recipients, acute graft-versus-host disease was limited to grade II or less, and no chronic graft-versus-host disease developed. Both of these patients have maintained complete remission for more than 8 months post-SCT. Non-T-cell-depleted SCT from haploidentical HLA 2 loci-mismatched family donors seems feasible if microchimerism is detectable.
Ishida
Hiroyuki
H
Division of Pediatrics, Matsushita Memorial Hospital, Osaka, Japan. PANA7660@pas.mei.co.jp
Morimoto
Akira
A
Yoshihara
Takao
T
Kuroda
Hiroshi
H
Mori
Kanako
K
Fujii
Noriko
N
Tamura
Shinichi
S
Hibi
Shigeyoshi
S
Todo
Shinjiro
S
Maruya
Etsuko
E
Imashuku
Shinsaku
S
D002648:Child; D002678:Chimera; D018572:Disease-Free Survival; D005260:Female; D005331:Fetomaternal Transfusion; D006085:Graft Survival; D006086:Graft vs Host Disease; D006239:Haplotypes; D019337:Hematologic Neoplasms / Q000150:complications / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006648:Histocompatibility / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D007108:Immune Tolerance; D008297:Male; D009679:Nuclear Family; D011247:Pregnancy; D014019:Tissue Donors