Increased expression of MUC1 in advanced pancreatic cancer.
BACKGROUND
MUC1 is associated with tumor invasion and metastasis, and is expressed in pancreatic cancer with a high frequency. This study explored whether MUC1 expression affected the survival of patients with pancreatic cancer.


METHODS
Tissue specimens obtained from 70 patients with invasive ductal carcinoma of the pancreas, in pTNM stage III or IV, were immunostained with the anti-MUC1 monoclonal antibody DF3. The results of immunostaining were determined to be positive when more than 50% of the total cancer cells were positively stained. Association of the expression of the DF3 epitope with clinicopathological parameters or patients' survival was statistically evaluated.


RESULTS
The incidence of positivity of MUC1 expression was 55.7% (39/70) and this incidence was significantly higher in pTNM stage IV than in stage III (odds ratio [OR], 4.015; 95% confidence interval [CI], 1.459-11.0541; P = 0.0076). As there was a clear difference in overall survival between pTNM stages III and IV ( P = 0.0016), the effect of MUC1 expression on survival was separately evaluated in each stage. It was shown that the expression of MUC1 was associated with unfavorable overall survival in stage IV ( P = 0.0197).


CONCLUSIONS
Our data suggest that the expression of MUC1 may be related to the progression of pancreatic cancer.
Hinoda
Yuji
Y
Department of Clinical Laboratory Science, 1-1-1 Minami-Kogushi, 755-8505, Ube, Japan.
Ikematsu
Yoshito
Y
Horinochi
Michiko
M
Sato
Shuji
S
Yamamoto
Kotaro
K
Nakano
Tomoko
T
Fukui
Mikiko
M
Suehiro
Yutaka
Y
Hamanaka
Yuichiro
Y
Nishikawa
Yoshiro
Y
Kida
Hideo
H
Waki
Shinji
S
Oka
Masaaki
M
Imai
Kohzoh
K
Yonezawa
Suguru
S
D000328:Adult; D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D018604:Epitope Mapping; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism*; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate
D018396:Mucin-1