Resuscitation-promoting factors possess a lysozyme-like domain.
The novel bacterial cytokine family--resuscitation-promoting factors (Rpfs)--share a conserved domain of uncharacterized function. Predicting the structure of this domain suggests that Rpfs possess a lysozyme-like domain. The model highlights the good conservation of residues involved in catalysis and substrate binding. A lysozyme-like function makes sense for this domain in the light of experimental characterization of the biological function of Rpfs.
Cohen-Gonsaud
Martin
M
School of Crystallography and BBRSC Centre for Structural Biology, Birkbeck College, University of London, Malet Street, London, WC1E 7HX, UK.
Keep
Nicholas H
NH
Davies
Angharad P
AP
Ward
John
J
Henderson
Brian
B
Labesse
Gilles
G
D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins; D016207:Cytokines / Q000737:chemistry* / Q000235:genetics*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009113:Muramidase / Q000737:chemistry / Q000235:genetics*; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D001426:Bacterial Proteins; D016207:Cytokines; C113704:resuscitation-promoting factor, bacteria; D009113:Muramidase