title: Inter- and intraoperator reliability of brain tissue measures using magnetic resonance imaging.
abstract: Grey matter, white matter and cerebrospinal volume in the human brain were measured using magnetic resonance image analysis software BRAINS. Ten volunteers were scanned in the MR sequence (3D-SPGR; 1.5-mm slice thickness and T2 images; 3mm slice thickness). Two operators obtained ten volume measures of grey matter,white matter and cerebrospinal fluid (CSF) in the intracranial box, frontal box, temporal box, parietal box and occipital box. The same data set of ten scans was segmented and the volumes measured on a second occasion by one operator using the same procedure. The interoperator and intraoperator reliabilities for measures of the three brain tissues were very good, with reliability coefficients (intraclass correlation coefficients) ranging between 0.971 and 0.999. The segmentation and measurement are useful for volumetric studies in the human brain using BRAINS.
authors.affiliation: Dept. of Neuropsychiatry, Kansai Medical University, 10-15 Fumizonocho Moriguchi, Osaka 570-8506, Japan. okugawa@takii.kmu.ac.jp
authors.forename: Gaku
authors.initials: G
authors.lastname: Okugawa
authors.forename: Katsunori
authors.initials: K
authors.lastname: Takase
authors.forename: Kenji
authors.initials: K
authors.lastname: Nobuhara
authors.forename: Tsunetaka
authors.initials: T
authors.lastname: Yoshida
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Minami
authors.forename: Chiharu
authors.initials: C
authors.lastname: Tamagaki
authors.forename: Vincent A
authors.initials: VA
authors.lastname: Magnotta
authors.forename: Nancy C
authors.initials: NC
authors.lastname: Andreasen
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kinoshita
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D010054:Brief Psychiatric Rating Scale; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size / Q000502:physiology; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000473:pathology / Q000503:physiopathology; D012984:Software; D014894:Weights and Measures