title: TGN38/41: a molecule on the move.
abstract: TGN38/41 is a heterodimeric integral membrane protein that cycles between the trans Golgi network and the cell surface. A tyrosine-containing tetrapeptide motif within its cytoplasmic tail is necessary and sufficient for determining its steady-state location in the TGN. Recent results have shown that TGN38/41 plays an essential role in the formation of exocytic vesicles at the TGN by serving as a receptor for complexes of a cytoplasmic protein known as p62, and one of four small GTP-binding proteins, including rab6. For budding to occur, this complex must bind to the cytoplasmic domain of TGN38/41. We propose here that TGN38/41 may couple the segregation of secretory proteins to the budding of exocytic vesicles at the TGN.
authors.affiliation: Heart Research Institute, 145 Missenden Road, Camperdown, Sydney, NSW 2050, Australia.
authors.forename: K K
authors.initials: KK
authors.lastname: Stanley
authors.forename: K E
authors.initials: KE
authors.lastname: Howell