title: G388R mutation of the FGFR4 gene is not relevant to breast cancer prognosis.
abstract: This study screened large cohorts of node-positive and node-negative breast cancer patients to determine whether the G388R mutation of the FGFR4 gene is a useful prognostic marker for breast cancer as reported by Bange et al in 2002. Node-positive (n=139) and node-negative (n=95) breast cancer cohorts selected for mutation screening were followed up for median periods of 89 and 87 months, respectively. PCR - RFLP analysis was modified to facilitate molecular screening. Curves for disease-free survival were plotted according to the Kaplan - Meier method, and a log-rank test was used for comparisons between groups. Three other nonparametric linear rank-tests particularly suitable for investigating possible relations between G388R mutation and early cancer progression were also used. Kaplan - Meier analysis based on any of the four nonparametric linear rank tests performed for node-positive and node-negative patients was not indicative of disease-free survival time. G388R mutation of the FGFR4 gene is not relevant for breast cancer prognosis.
authors.affiliation: Département de Biologie Oncologique, Centre Régional de Lutte Contre le Cancer, René Gauducheau, boulevard Jacques Monod, 44805 Saint Herblain, France. p-jezequel@nantes.fnclcc.fr
authors.forename: P
authors.initials: P
authors.lastname: Jézéquel
authors.forename: L
authors.initials: L
authors.lastname: Campion
authors.forename: M-P
authors.initials: MP
authors.lastname: Joalland
authors.forename: M
authors.initials: M
authors.lastname: Millour
authors.forename: F
authors.initials: F
authors.lastname: Dravet
authors.forename: J-M
authors.initials: JM
authors.lastname: Classe
authors.forename: V
authors.initials: V
authors.lastname: Delecroix
authors.forename: R
authors.initials: R
authors.lastname: Deporte
authors.forename: P
authors.initials: P
authors.lastname: Fumoleau
authors.forename: G
authors.initials: G
authors.lastname: Ricolleau
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D005346:Fibroblast Growth Factors; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020125:Mutation, Missense; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D011379:Prognosis; D051499:Receptor, Fibroblast Growth Factor, Type 4; D017468:Receptors, Fibroblast Growth Factor / Q000235:genetics*; D015398:Signal Transduction
chemical_list: D014408:Biomarkers, Tumor; D017468:Receptors, Fibroblast Growth Factor; D005346:Fibroblast Growth Factors; C496371:FGFR4 protein, human; D051499:Receptor, Fibroblast Growth Factor, Type 4