[Effects of the lipid-lowering drugs on endothelial hyperplasia in inferior vena cava grafts in dogs].
OBJECTIVE
To investigate the effects of the lipid-lowering drugs in alleviating endothelial hyperplasia in the inferior vena cava (IVC) grafts in dogs.


METHODS
The Dacron grafts seeded with autologous venous fragments were implanted into the IVC of 20 dogs, including 12 dogs receiving oral lipid-lowering drugs serving as the treatment group and the other 8 without medication as the control group. The levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-ch) and high-density lipoprotein cholesterol (HDL-ch) in the serum were measured regularly, and all the grafts harvested to measure the thickness of the endothelium.


RESULTS
The total patency rate of the IVC were higher in the treatment group (75%) than in the control group (37.5%), and new endothelial lining was formed two weeks after the operation. Compared with the control group, the endothelial thickness of the grafts at the proximal (P<0.01), middle (P<0.05) and distal segments (P<0.05) of the IVC were all smaller in the treatment group, which also had lower serum LDL-ch and TC levels (both P<0.05) but with comparable HDL-ch levels (P>0.05).


CONCLUSIONS
Administration of lipid-lowering drugs may reduce the level of serum LDL-ch and TC and the endothelial thickness of the grafts to improve the patency rate of the vessels.
Wu
Ai-guo
AG
Department of General Surgery, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. wagtyz@21cn.com
Chen
Hai-jin
HJ
Tan
Yi-zhen
YZ
Yao
Hong-bing
HB
Huang
Zong-hai
ZH
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004285:Dogs; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006965:Hyperplasia; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D014682:Vena Cava, Inferior / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure
D000960:Hypolipidemic Agents; D002784:Cholesterol