OXYS rats as a model of senile cataract.
Changes in the lens appear by the age of 2 months in early aging OXYS rats, at the age of 6 months these changes are detected in 100% animals, and by 12 months both eyes are involved. According to biomicroscopy findings, predominant forms of cataract are vesicular, annular, and dendritic, located in the cortical layer and/or nucleus of the lens. Light and electron microscopy showed morphological changes involving all structural components of the lens: epithelial degeneration progressing with age, deformation of fiber architectonics, and appearance of uneven condensations. Cataract in OXYS rats corresponds to senile cataract, which makes this rat strain a unique model for studies of the pathogenesis of involutive cataract and elaboration of methods for its prevention and correction.
Kolosova
N G
NG
Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk. kolosova@bionet.nsc.ru
Lebedev
P A
PA
Aidagulova
S V
SV
Morozkova
T S
TS
D017668:Age of Onset; D019588:Aging, Premature / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D002386:Cataract / Q000150:complications / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D015994:Incidence; D007908:Lens, Crystalline / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar