[Neurobiology and modern approaches to the treatment of Alzheimer disease].
Alzheimer's disease (AD) is the most common type of dementia among older people. AD is characterized as neurodegenerative disease showing impairment of cognitive function, death of neuronal cells, numerous numbers of senile plaques and tangle of neurofilaments. The paper contains the literary review concerning the most important neurobiological mechanisms of the AD development. The modern strategy of treatment such as acetylcholine esterase inhibitors, neuroprotectors, neurotrophic factors, inhibitors of beta- and gamma-secretase, beta-amyloid aggregation inhibitors, beta-amyloid degradation stimulators, beta-amyloid vaccination, inhibitors of tau protein phosphorylation, estrogens, nonsteroid anti-inflammatory drugs is discussed.
Levada
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D000544:Alzheimer Disease / Q000188:drug therapy / Q000209:etiology / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D009154:Mutation; D018696:Neuroprotective Agents / Q000627:therapeutic use; D053764:Presenilin-1; D053766:Presenilin-2
D016564:Amyloid beta-Protein Precursor; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D002800:Cholinesterase Inhibitors; D008565:Membrane Proteins; D018696:Neuroprotective Agents; C508853:PSEN1 protein, human; C508861:PSEN2 protein, human; D053764:Presenilin-1; D053766:Presenilin-2