title: Early carotid endarterectomy after acute stroke.
abstract: OBJECTIVE
  Carotid endarterectomy (CEA) after acute stroke is generally delayed 6 to 8 weeks because of fear of stroke progression. This delay can result in an interval stroke rate of 9% to 15%. We analyzed our results with CEA performed within 1 to 4 weeks of stroke.
  
  
  METHODS
  Records for all patients undergoing CEA after stroke between 1980 and 2001 were analyzed. Perioperative evaluation included carotid duplex scanning or angiography, and head computed tomography or magnetic resonance imaging. All patients with nonworsening neurologic status, additional brain territory at risk for recurrent stroke, and severe ipsilateral carotid stenosis underwent CEA. Patients were grouped according to time of CEA after stroke: group 1, first week; group 2, second week; group 3, third week; group 4, fourth week. Statistical analysis was performed with the chi(2) test, logistic regression, and analysis of variance.
  
  
  RESULTS
  Two hundred twenty-eight patients underwent CEA within 1 to 4 weeks of stroke. Perioperative permanent neurologic deficits occurred in 2.8% of patients in group 1 (72 procedures), 3.4% of patients in group 2 (59 procedures), 3.4% of patients in group 3 (29 procedures), and 2.6% of patients in group 4 (78 procedures). There was no relationship between location or size of preoperative infarct and time of surgery. Only preoperative infarct size correlated with probability of neurologic deficit after CEA (P <.05).
  
  
  CONCLUSIONS
  Incidence of postoperative stroke exacerbation is similar at all intervals. The results are within acceptable limits for treatment of symptomatic carotid stenosis. CEA may be performed within 1 month of stroke with similar results at all intervals during this period.
authors.affiliation: Institute for Vascular Health and Disease, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA.
authors.forename: Philip S K
authors.initials: PS
authors.lastname: Paty
authors.forename: R Clement
authors.initials: RC
authors.lastname: Darling
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Feustel
authors.forename: Gary L
authors.initials: GL
authors.lastname: Bernardini
authors.forename: Manish
authors.initials: M
authors.lastname: Mehta
authors.forename: Kathleen J
authors.initials: KJ
authors.lastname: Ozsvath
authors.forename: Daniel
authors.initials: D
authors.lastname: Choi
authors.forename: Sean P
authors.initials: SP
authors.lastname: Roddy
authors.forename: Benjamin B
authors.initials: BB
authors.lastname: Chang
authors.forename: Paul B
authors.initials: PB
authors.lastname: Kreienberg
authors.forename: Dhiraj M
authors.initials: DM
authors.lastname: Shah
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging; D016893:Carotid Stenosis / Q000150:complications / Q000601:surgery; D016894:Endarterectomy, Carotid / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012008:Recurrence; D012307:Risk Factors; D020521:Stroke / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D014057:Tomography, X-Ray Computed