title: Effects of phencyclidines on signal transfer from the entorhinal cortex to the hippocampus in rats.
abstract: The information transfer from the superficial layers of the entorhinal cortex (EC) to the hippocampus is regulated in a frequency dependent manner. Phencyclidine and related compounds such as MK-801 produce psychotic symptoms that closely resemble schizophrenia. We studied the effects of systemic administration of MK-801 on the signal transfer from the EC layer III to the hippocampal area CA1. High frequency (above 10 Hz) activation of the bi-synaptic entorhinal input in control animals results in a strong suppression of the field potentials in the stratum lacunosum-moleculare of the area CA1. In contrast, in MK-801 pretreated rats the field response was less reduced. The field potential responses evoked in these two groups of animals by high-frequency activation of the monosynaptic input were similar suggesting selective alterations in layer III of the medial EC. We suggest, that MK-801 causes disinhibition of layer III projection cells and, therefore, may cause strong, pathological activation of direct layer III-CA1 pathway.
authors.affiliation: Johannes-Müller-Institute of Physiology at the Charité, Humboldt University, Berlin, Tucholskystrasse 2, 10117 Berlin, Germany.
authors.forename: Tamar
authors.initials: T
authors.lastname: Dugladze
authors.forename: Eka
authors.initials: E
authors.lastname: Lepsveridze
authors.forename: Jörg
authors.initials: J
authors.lastname: Breustedt
authors.forename: Colin
authors.initials: C
authors.lastname: Kehrer
authors.forename: Uwe
authors.initials: U
authors.lastname: Heinemann
authors.forename: Tengis
authors.initials: T
authors.lastname: Gloveli
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004307:Dose-Response Relationship, Radiation; D004558:Electric Stimulation / Q000379:methods; D018728:Entorhinal Cortex / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D005260:Female; D006624:Hippocampus / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D009431:Neural Conduction / Q000187:drug effects*; D009434:Neural Pathways / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats
chemical_list: D018691:Excitatory Amino Acid Antagonists; D016291:Dizocilpine Maleate; D010622:Phencyclidine