Possible role of alteration of aldehyde's scavenger enzymes during aging.
Apoptosis in tissues is induced by different kind of signals including endogenous aldehydes, such as 4-hydroxy-2, 3-nonenal. The accumulation rate of aldehydes in the cell is affected by conditions of oxidative stress. In the cell, aldehydes can be metabolized by various isoforms of aldehyde dehydrogenase, aldehyde reductase, and glutathione-S-transferase. There is evidence suggesting that the catalytic properties of these enzymes change during ontogenesis, and that aging is accompanied by their reduced activities. These functional changes may contribute substantially to the alteration in the organism sensitivity to damaging action of stress factors during aging, to age-related modulation of the action of endogenous aldehydes as a signal for apoptosis, and finally, to the origin of diseases associated with aging. In this context, the stimulation of enzymes' expression, and the activation of the catalytic properties of enzymes responsible for catabolism of endogenous aldehydes could become a perspective direction in increasing the organism resistance to the action of damaging factors during aging.
Davydov
Vadim V
VV
Laboratory of Age Biochemistry and Endocrinology, Institute of Children and Adolescent Health Protection, Academy of Medical Science, 50-Let VLKSM av 52A, Kharkov 61153, Ukraine. dav@nord.vostok.net
Dobaeva
Nataly M
NM
Bozhkov
Anatoly I
AI
D000368:Aged; D000375:Aging / Q000502:physiology*; D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D000449:Aldehyde Reductase / Q000378:metabolism; D000447:Aldehydes / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D016166:Free Radical Scavengers / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress; D051381:Rats
D000447:Aldehydes; D016166:Free Radical Scavengers; D000449:Aldehyde Reductase; D000444:Aldehyde Dehydrogenase; D005982:Glutathione Transferase