Criteria for predicting the outcome of pheochromocytoma by the immunohistochemical and electron microscopic findings.
Morphological examination of 22 functionally active adrenal pheochromocytomas was carried out. The content of catecholamine granules in tumor cells and in the number of sustentacular cells tended to decrease in metastasizing tumors. Electron microscopy showed two types of sustentacular cells and the possibility of their apoptotic death.
Bezuglova
T V
TV
Central Pathoanatomical Laboratory, Institute of Human Morphology, Russian Academy of Medical Sciences; Department of Pathology, M. F. Vladimirskii Moscow Regional Research and Clinical Institute.
D000310:Adrenal Gland Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure*; D014408:Biomarkers, Tumor; D002395:Catecholamines / Q000378:metabolism; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism / Q000648:ultrastructure; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004837:Epinephrine / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D016253:Microscopy, Immunoelectron; D010673:Pheochromocytoma / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure*; D009418:S100 Proteins / Q000378:metabolism / Q000648:ultrastructure
D014408:Biomarkers, Tumor; D002395:Catecholamines; D053379:Chromogranin A; D002864:Chromogranins; D009418:S100 Proteins; D004837:Epinephrine