An Arf(GFP/GFP) reporter mouse reveals that the Arf tumor suppressor monitors latent oncogenic signals in vivo.
Understanding how the Arf tumor suppressor is activated in response to abnormally elevated mitogenic signaling thresholds is a particularly vexing problem. Studies of a knock-in mouse strain in which sequences encoding green fluorescent protein were substituted for those encoding p19Arf argue that the Arf gene responds to latent oncogenic signals in vivo to eliminate incipient cancer cells.
Sherr
Charles J
CJ
Howard Hughes Medical Institute, Department of Genetics & Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38117, USA. sherr@stjude.org
D000818:Animals; D019941:Cyclin-Dependent Kinase Inhibitor p16; D017930:Genes, Reporter / Q000235:genetics*; D016147:Genes, Tumor Suppressor; D049452:Green Fluorescent Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051379:Mice; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D025803:Tumor Suppressor Protein p14ARF / Q000235:genetics / Q000378:metabolism*
C417743:Cdkn2a protein, mouse; D019941:Cyclin-Dependent Kinase Inhibitor p16; D015513:Oncogene Proteins; D025803:Tumor Suppressor Protein p14ARF; D049452:Green Fluorescent Proteins