title: ALK-negative T-cell anaplastic large cell lymphoma associated with systemic lupus erythematosus.
abstract: Patients with systemic lupus erythematosus (SLE) appear to have an increased risk of developing malignancies, especially lymphomas. We report the development of a systemic ALK-negative T-cell anaplastic large cell lymphoma, stage IIB, in a 53-yr-old Caucasian female with a 12-yr history of stable SLE. The patient responded poorly to chemotherapy and died 2 yr after diagnosis. Lymphomas that develop in patients with SLE and other autoimmune diseases are virtually always of B-cell origin. To our knowledge this is the first report of a T-cell anaplastic large cell lymphoma in a patient with SLE. This article discusses the association of SLE and lymphoma, with an emphasis on T-lymphoproliferative states.
authors.affiliation: Institute of Hematology, Clinical Center of Serbia, 2 Koste Todorovic str., 11000 Belgrade, Serbia and Montenegro. nvukovic@Eunet.yu
authors.forename: Nada
authors.initials: N
authors.lastname: Suvajdzic
authors.forename: Roksanda
authors.initials: R
authors.lastname: Stojanovic-Milenkovic
authors.forename: Zoran
authors.initials: Z
authors.lastname: Tomasevic
authors.forename: Vesna
authors.initials: V
authors.lastname: Cemerikic-Martinovic
authors.forename: Biljana
authors.initials: B
authors.lastname: Mihaljevic
authors.forename: Henry D E
authors.initials: HD
authors.lastname: Atkinson
mesh_terms: D000328:Adult; D002277:Carcinoma / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D016399:Lymphoma, T-Cell / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology