title: [Frequency of genetic diseases and cancer antecedents in 493 adults with visceral or soft tissue sarcomas].
abstract: Little is known about epidemiology of adults soft tissue and visceral sarcomas (ASTS). The frequency of previous cancers and associated genetic diseases has been analyzed out of 493 ASTS, treated between 1997 and 2002 at Oscar Lambret Cancer Center. Median age is 51, sex ratio is close to 1. Liposarcomas and malignant fibrous histiocytofibromas are the two main types (respectively 104 and 86 cases). Upper and lower limbs are the two main locations (respectively 176 and 75 cases). Fifteen patients had associated genetic disease, including 12 cases of Recklinghausen diseases. 7 out of those 15 patients have neurosarcoma. 30 patients have previous cancers, including 7 breast cancers, 3 lymphomas and 3 chronic lymphocytic leukemias. Four out of those 30 patients have two different previous cancers. 13 patients have radiation-induced sarcomas, after an average 10-year-period, and an average dose of 53 Gy. Undifferenciated sarcomas are the main histologic type (8/13), followed by angiosarcomas (2/13). Radiation-induced sarcomas are located in the chest wall (7/13), in pelvis (2/13) and head and neck (2/13). Those sarcomas are high grade (10 grade III tumours). ASTS epidemiology is complex with different risk factors depending on histologic type.
authors.affiliation: Département de cancérologie générale, Comité Sarcome du centre Oscar-Lambret, 3, rue Frédéric-Combemale, 59020 Lille. n-penel@o-lambret.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Penel
authors.forename: Gérard
authors.initials: G
authors.lastname: Depadt
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Vilain
authors.forename: Luc
authors.initials: L
authors.lastname: Vanseymortier
authors.forename: Luc
authors.initials: L
authors.lastname: Ceugnart
authors.forename: Sophie
authors.initials: S
authors.lastname: Taieb
authors.forename: Xavier
authors.initials: X
authors.lastname: Mirabel
authors.forename: Nathalie
authors.initials: N
authors.lastname: Deligny
authors.forename: Annick
authors.initials: A
authors.lastname: Chevalier
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Baranzelli
authors.forename: Fabienne
authors.initials: F
authors.lastname: Pichon
authors.forename: Dominique
authors.initials: D
authors.lastname: Hoguet
authors.forename: Yves-Marie
authors.initials: YM
authors.lastname: Robin
authors.forename: Eric
authors.initials: E
authors.lastname: Lartigau
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D030342:Genetic Diseases, Inborn / Q000150:complications / Q000453:epidemiology*; D018219:Histiocytoma, Benign Fibrous / Q000453:epidemiology; D006801:Humans; D008080:Liposarcoma / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology*; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D012509:Sarcoma / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology