title: Clinical experience with minocycline and rifampin-impregnated central venous catheters in bone marrow transplantation recipients: efficacy and low risk of developing staphylococcal resistance.
abstract: In this retrospective evaluation of the 4-year clinical use of minocycline and rifampin-impregnated catheters in bone marrow transplantation (BMT) patients, we report low risk of development of staphylococcal resistance to the antibiotics coating the catheters and efficacy in preventing primary staphylococcal bloodstream infections.
authors.affiliation: Department of Infectious Diseases, Infectious Control and Employee Health, University of Texas, M. D. Anderson Cancer Center, Houston 77030, USA.
authors.forename: Ioannis
authors.initials: I
authors.lastname: Chatzinikolaou
authors.forename: Hend
authors.initials: H
authors.lastname: Hanna
authors.forename: Linda
authors.initials: L
authors.lastname: Graviss
authors.forename: Gassan
authors.initials: G
authors.lastname: Chaiban
authors.forename: Cheryl
authors.initials: C
authors.lastname: Perego
authors.forename: Rebecca
authors.initials: R
authors.lastname: Arbuckle
authors.forename: Richard
authors.initials: R
authors.lastname: Champlin
authors.forename: Rabih
authors.initials: R
authors.lastname: Darouiche
authors.forename: George
authors.initials: G
authors.lastname: Samonis
authors.forename: Issam
authors.initials: I
authors.lastname: Raad
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000494:pharmacology; D000904:Antibiotics, Antitubercular / Q000008:administration & dosage* / Q000494:pharmacology; D016026:Bone Marrow Transplantation / Q000295:instrumentation; D002405:Catheterization, Central Venous / Q000009:adverse effects / Q000295:instrumentation*; D002408:Catheters, Indwelling / Q000382:microbiology*; D015331:Cohort Studies; D003428:Cross Infection / Q000209:etiology / Q000517:prevention & control*; D016503:Drug Delivery Systems; D004351:Drug Resistance; D005260:Female; D006801:Humans; D017053:Infection Control / Q000379:methods; D007938:Leukemia / Q000601:surgery; D008297:Male; D008875:Middle Aged; D008911:Minocycline / Q000008:administration & dosage* / Q000494:pharmacology; D009503:Neutropenia / Q000382:microbiology / Q000517:prevention & control*; D012293:Rifampin / Q000008:administration & dosage* / Q000494:pharmacology; D013203:Staphylococcal Infections / Q000209:etiology / Q000517:prevention & control*; D013781:Texas
chemical_list: D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D008911:Minocycline; D012293:Rifampin