Receptor-mediated regulation of constitutive secretion.
The traditional distinction between regulated and constitutive secretion may have contributed to the general belief that the latter is insensitive to extracellular modulatory signals. However, it now appears that signalling from membrane receptors can in fact modulate constitutive membrane traffic. In this article we discuss the molecular mechanisms, as well as the functional significance, of this modulation.
Luini
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Laboratory of Molecular Neurobiology, Mario Negri Institute of Pharmacological Research, Consorzio Mario Negri Sud, 66030 Santa Maria, Imbaro, Chieti, Italy.
De Matteis
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MA