Evaluation of interaction between gabapentin and baclofen in the formalin test in mice.
Gabapentin and baclofen at doses not affecting motor performance, produced dose-dependent inhibition of both phases in the formalin test in mice. Isobolographic analysis revealed an additive interaction between the studied drugs in the second phase of the formalin test. Gabapentin given at doses effective in both phases of the formalin test significantly potentiated baclofen-induced motor impairment.
Czuczwar
Mirosław
M
Second Department of Anesthesiology and Intensive Therapy, Medical University, Staszica 16, PL 20-081 Lublin, Poland.
Kiś
Jacek
J
Łuszczki
Jarogniew
J
Turski
Waldemar A
WA
Przesmycki
Krzysztof
K
D000085:Acetates / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000588:Amines; D000818:Animals; D001418:Baclofen / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D003509:Cyclohexanecarboxylic Acids; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D000077206:Gabapentin; D007274:Injections, Intraperitoneal; D051379:Mice; D009069:Movement Disorders / Q000503:physiopathology; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D001418:Baclofen