Acute myeloid leukemia presenting simultaneously in two siblings.
The rare occurrence of acute myeloid leukemia simultaneously in two siblings, 3-year male and 1-year female, in the absence of any known predisposing condition is reported. We speculate that an initial in-utero genetic alteration followed by subsequent environmental exposure to some unknown toxin may have resulted in leukemogenesis.
Jain
Vandana
V
Department of Pediatrics, Division of Pediatric Oncology, All India Institute of Medical Sciences, New Delhi 110029, India.
Bakhshi
Sameer
S
Chan
Mei-Yoke
MY
Arya
L S
LS
D002675:Child, Preschool; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000235:genetics*; D008297:Male; D018570:Risk Assessment; D012720:Severity of Illness Index; D035781:Siblings