Diffusion tensor MR imaging visualizes the altered hemispheric fiber connection in callosal dysgenesis.
We report three cases of callosal dysgenesis that were evaluated by diffusion tensor imaging and fiber tractography. In partial agenesis of corpus callosum, fiber tracts from all regions of brain converged to a partially developed small genu portion and connected to the contralateral side. In complete callosal agenesis, fibers from the hemispheres failed to cross the midline and formed thick bundles running anteroposteriorly (eg, Probst bundle). The thickness of the anterior commissure was enlarged or smaller than normal brain, and other white matter tracts were not markedly different from normal brain tissue.
Lee
Seung-Koo
SK
Department of Diagnostic Radiology and Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul, Korea.
Mori
Susumu
S
Kim
Dong Joon
DJ
Kim
Sei Young
SY
Kim
Si Yeon
SY
Kim
Dong Ik
DI
D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging / Q000473:pathology; D061085:Agenesis of Corpus Callosum; D016880:Anisotropy; D002552:Cerebral Ventricles / Q000473:pathology; D003337:Corpus Callosum / Q000000981:diagnostic imaging*; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D007223:Infant; D007229:Infant Welfare; D007231:Infant, Newborn; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000000981:diagnostic imaging* / Q000473:pathology*; D011856:Radiographic Image Enhancement