title: MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test.
abstract: The Bergman Minimal Model enables estimation of two key indices of glucose/insulin dynamics: glucose effectiveness and insulin sensitivity. In this paper we describe MINMOD Millennium, the latest Windows-based version of minimal model software. Extensive beta testing of MINMOD Millennium has shown that it is user-friendly, fully automatic, fast, accurate, reproducible, repeatable, and highly concordant with past versions of MINMOD. It has a simple interface, a comprehensive help system, an input file editor, a file converter, an intelligent processing kernel, and a file exporter. It provides publication-quality charts of glucose and insulin and a table of all minimal model parameters and their error estimates. In contrast to earlier versions of MINMOD and some other minimal model programs, Millennium provides identified estimates of insulin sensitivity and glucose effectiveness for almost every subject.
authors.affiliation: School of Veterinary Medicine, University of Pennsylvania, Kennett Square, Pennsylvania 19348, USA. Boston@vet.upenn.edu
authors.forename: Ray C
authors.initials: RC
authors.lastname: Boston
authors.forename: Darko
authors.initials: D
authors.lastname: Stefanovski
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Moate
authors.forename: Anne E
authors.initials: AE
authors.lastname: Sumner
authors.forename: Richard M
authors.initials: RM
authors.lastname: Watanabe
authors.forename: Richard N
authors.initials: RN
authors.lastname: Bergman
mesh_terms: D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D003194:Computer-Assisted Instruction; D005951:Glucose Tolerance Test / Q000379:methods*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000494:pharmacology*; D008954:Models, Biological; D015203:Reproducibility of Results; D012984:Software; D014584:User-Computer Interface
chemical_list: D001786:Blood Glucose; D007328:Insulin