Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis.
Idiopathic narcolepsy is associated with deficient hypocretin transmission. Narcoleptic symptoms have recently been described in paraneoplastic encephalitis with anti-Ma2 antibodies. The authors measured CSF hypocretin-1 levels in six patients with anti-Ma2 encephalitis, and screened for anti-Ma antibodies in patients with idiopathic narcolepsy. Anti-Ma autoantibodies were not detected in patients with idiopathic narcolepsy. Four patients with anti-Ma2 encephalitis had excessive daytime sleepiness; hypocretin-1 was not detectable in their cerebrospinal fluid, suggesting an immune-mediated hypocretin dysfunction.
Overeem
S
S
Department of Neurology, Leiden University Medical Centre, the Netherlands.
Dalmau
J
J
Bataller
L
L
Nishino
S
S
Mignot
E
E
Verschuuren
J
J
Lammers
G J
GJ
D000230:Adenocarcinoma / Q000276:immunology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm; D020274:Autoimmune Diseases of the Nervous System / Q000134:cerebrospinal fluid* / Q000150:complications / Q000276:immunology; D002352:Carrier Proteins / Q000134:cerebrospinal fluid*; D004660:Encephalitis / Q000134:cerebrospinal fluid* / Q000150:complications / Q000276:immunology; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008175:Lung Neoplasms / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000150:complications / Q000276:immunology; D009419:Nerve Tissue Proteins; D009479:Neuropeptides / Q000134:cerebrospinal fluid*; D000068797:Orexins; D010051:Ovarian Neoplasms / Q000276:immunology; D020361:Paraneoplastic Syndromes, Nervous System / Q000134:cerebrospinal fluid* / Q000150:complications / Q000276:immunology; D011506:Proteins / Q000276:immunology*; D013736:Testicular Neoplasms / Q000276:immunology
D000951:Antigens, Neoplasm; D002352:Carrier Proteins; C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; C119249:Ma2 antigen; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D000068797:Orexins; D011506:Proteins