[Aprotinin reduces myocardial injury in the off-pump coronary artery bypass grafting].
OBJECTIVE
To investigate the effect of aprotinin on the myocardial injury during the off-pump coronary artery bypass grafting (OPCAB).


METHODS
Twenty-four patients undergoing OPCAB randomly were of 12 patients divided into two groups: aprotinin group and Control group (n = 12). In the aprotinin group a loading dose (2 x 10(6) KIU) was administered within the first 30 minutes after the induction followed by continuous infusion of 0.5 x 10(6) KIU/h throughout the operation. The plasma myocardial injury markers CK-MB and cTnI were measured at the four points: (1) After induction; (2) 1 hour after coronary anastomosis; (3) 6 hours and (4) 24 hours after the operation. The blood loss was recorded by autotransfusion in the operation, and the drainage immediately, 6 hours, and 24 hours after the operation.


RESULTS
Myocardial injury markers CK-MB and cTnI increased significantly after the anastomosis in each group; cTnI was lower in the aprotinin group than in the control group at the third and forth points (P < 0.05). The post-operative drainage after 6 hours and 24 hours were lower in the aprotinin group than in control group (P < 0.05).


CONCLUSIONS
There is the myocardial injury during OPCAB. Aprotinin can reduce the myocardial injury during OPCAB.
Yang
Yang
Y
Department of Cardiac Surgery, Peking University First Hospital, Beijing 100034, China.
Xiao
Feng
F
Chen
Hong-yi
HY
Li
Yan
Y
Shi
Zhi-hui
ZH
D000368:Aged; D007611:Aprotinin / Q000494:pharmacology*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D005260:Female; D006321:Heart / Q000187:drug effects*; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D019210:Troponin I / Q000097:blood
D007527:Isoenzymes; D019210:Troponin I; D007611:Aprotinin; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form