title: Group index of the human cornea at 1.3-microm wavelength obtained in vitro by optical coherence domain reflectometry.
abstract: The group index of the cornea, rather than the phase refractive index, is required for thickness calculations with optical coherence tomography. Recent advances with high-speed optical coherence tomography at 1.3 microm make index measurement at this wavelength of great interest. Group indices of three human corneas from an eye bank were measured in vitro with optical coherence domain reflectometry. Measurements were made in a calibrated cuvette filled with a preservation medium to maintain proper corneal hydration. Group indices were calculated from the optical path lengths measured. The corneal group index was 1.389 +/- 0.004 (average +/- standard deviation). The average group index of a balanced salt solution, an approximation to aqueous humor, was 1.343 +/- 0.001.
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA.
authors.forename: Roger C
authors.initials: RC
authors.lastname: Lin
authors.forename: Mark A
authors.initials: MA
authors.lastname: Shure
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Rollins
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Izatt
authors.forename: David
authors.initials: D
authors.lastname: Huang
mesh_terms: D002809:Chondroitin Sulfates; D045424:Complex Mixtures; D003315:Cornea / Q000033:anatomy & histology*; D016895:Culture Media, Serum-Free; D003911:Dextrans; D005839:Gentamicins; D006801:Humans; D066298:In Vitro Techniques; D019188:Organ Preservation Solutions; D012542:Scattering, Radiation; D041623:Tomography, Optical Coherence
chemical_list: D045424:Complex Mixtures; D016895:Culture Media, Serum-Free; D003911:Dextrans; D005839:Gentamicins; D019188:Organ Preservation Solutions; D002809:Chondroitin Sulfates; C075736:Optisol