title: Frequencies of prion protein (PrP) genotypes and distribution of ages in 15 scrapie-affected flocks in Great Britain.
abstract: The frequencies of prion protein (PrP) genotypes were investigated in 15 scrapie-affected flocks in Great Britain. The flocks were heterogeneous in the frequencies of different genotypes and alleles, and in their age distributions. The median flock frequency of animals with VRQ-containing genotypes was 21 per cent (range 2 to 82 per cent, mean 25 per cent). The VRQ-containing and other non-ARR genotypes made up 11 to 82 per cent of a flock (median 46 per cent, mean 48 per cent). In comparison with data from the general population the scrapie-affected population had a lower frequency of the ARR/ARR genotype, and so of the ARR allele, and had a higher frequency of VRQ/non-ARR heterozygote genotypes, and thus of the VRQ allele.
authors.affiliation: Scrapie Epidemiology Group, VLA - Weybridge, Woodham Lane, New Haw, Addlestone KT15 3NB.
authors.forename: S C
authors.initials: SC
authors.lastname: Tongue
authors.forename: J W
authors.initials: JW
authors.lastname: Wilesmith
authors.forename: C J
authors.initials: CJ
authors.lastname: Cook
mesh_terms: D000483:Alleles; D000818:Animals; D004196:Disease Outbreaks / Q000662:veterinary*; D005787:Gene Frequency; D005838:Genotype; D018620:PrPSc Proteins / Q000235:genetics*; D012608:Scrapie / Q000453:epidemiology* / Q000209:etiology / Q000382:microbiology*; D012756:Sheep; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D018620:PrPSc Proteins