The 870G>A polymorphism of the cyclin D1 gene is not associated with breast cancer.
A common 870G > A polymorphism in the gene for cyclin D1, CCND1, has been linked to alternative splicing and cancer susceptibility. To analyze its role for breast cancer, we determined the CCND1 genotype in 500 breast cancer patients and 500 controls. CCND1 genotype frequencies were similar among patients and controls. The CCND1 genotype was furthermore not associated with tumor characteristics. We conclude that the CCND1 870G > A polymorphism is not associated with breast cancer.
Krippl
Peter
P
Department of Internal Medicine, Division of Oncology, Karl-Franzens University Graz, Graz, Austria. peter.krippl@klinikum-graz.at
Langsenlehner
Uwe
U
Renner
Wilfried
W
Yazdani-Biuki
Babak
B
Wolf
Gerald
G
Wascher
Thomas C
TC
Paulweber
Bernhard
B
Weitzer
Werner
W
Leithner
Andreas
A
Samonigg
Hellmut
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D017931:DNA Primers; D005260:Female; D019940:Genes, bcl-1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
D017931:DNA Primers