The adenosine A(2A) receptor as an attractive target for Parkinson's disease treatment.
Long-term L-dopa treatment of Parkinson's disease can lose its effectiveness and cause development of motor complications such as dyskinesia. Furthermore, L-dopa therapy does not address the fundamental pathological process of dopaminergic neurodegeneration in Parkinson's disease. This prompts a search for an alternative or complementary therapy for Parkinson's disease to overcome these limitations. During the last 5 years, the adenosine A(2A) receptor has emerged as an attractive target for Parkinson's disease therapy, primarily because of its localized expression in striatum and motor enhancement function. Recent genetic and pharmacological studies indicate that A(2A) receptor antagonists also offer neuroprotective effects and may possibly modify chronic L-dopa-induced maladaptive responses in animal models of Parkinson's disease. This review summarizes multiple potential benefits of the A(2A) receptor blockade in treating the motor symptoms as well as the underlying dopaminergic neurodegeneration of Parkinson's disease.
Chen
Jiang-Fan
JF
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118, USA. chenjf@bu.edu
D000241:Adenosine / Q000378:metabolism; D058917:Adenosine A2 Receptor Antagonists; D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology / Q000627:therapeutic use; D001921:Brain / Q000378:metabolism; D002110:Caffeine / Q000494:pharmacology / Q000627:therapeutic use; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D007980:Levodopa / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use; D010300:Parkinson Disease / Q000188:drug therapy* / Q000453:epidemiology / Q000378:metabolism; D043705:Receptor, Adenosine A2A / Q000378:metabolism; D017211:Treatment Failure
D058917:Adenosine A2 Receptor Antagonists; D000978:Antiparkinson Agents; D018696:Neuroprotective Agents; D043705:Receptor, Adenosine A2A; D002110:Caffeine; D007980:Levodopa; D000241:Adenosine; D004298:Dopamine