title: Relationship between malondialdehyde level and glutathione peroxidase activity in diabetic rats.
abstract: BACKGROUND
  This investigation describes the relationship between glutathione peroxidase activities, an antioxidant enzyme, and the oxidative status in diabetic rat blood.
  
  
  METHODS
  Malondialdehyde level and glutathione peroxidase activity were measured by spectrophotometric techniques.
  
  
  CONCLUSIONS
  Malondialdehyde content in the diabetic rats group was increased compared to that in the controls [3.08+/-0.32 (mean+/-S.E.) vs. 1.15+/-0.29 mM/g hemoglobin, P>0.01]. Glutathione peroxidase activity in the diabetic rats group was increased compared to that in the control [10.27+/-1.39 (mean+/-S.E.) vs. 3.14+/-0.38 micromol NADPH/min/g hemoglobin, P>0.01]. Our results show a positive correlation between serum glutathione peroxidase and malondialdehyde concentration in diabetic rats.
authors.affiliation: Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran. dqujeq@hotmail.com
authors.forename: Durdi
authors.initials: D
authors.lastname: Qujeq
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Aliakbarpour
authors.forename: Khodaberdi
authors.initials: K
authors.lastname: Kalavi
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D005979:Glutathione Peroxidase / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013053:Spectrophotometry / Q000379:methods
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D008315:Malondialdehyde; D005979:Glutathione Peroxidase