title: The course of depression in elderly patients.
abstract: OBJECTIVE
  Studies on the course of major depressive disorder (MDD) among elderly persons are limited to short periods of follow-up, seldom provide comparisons with younger cohorts, and raise other methodological concerns.
  
  
  METHODS
  Utilizing 15 years of prospective data from the NIMH Collaborative Depression Study, the authors examined the index episode of MDD and the time until first observed recurrence in those who recovered for subjects in four age-groups defined by age at intake: 17-30, 31-50, 51-64, and 65-79 years. Assessments were conducted every 6 months for 5 years and annually thereafter. Survival analysis examined time until recovery and time to first recurrence.
  
  
  RESULTS
  Median time-to-recovery was similar for the four groups. Median time-to-first recurrence was significantly shorter for oldest versus the 51-64-year-old group but not the two other groups. The oldest age-group was distinguished from the younger groups by being more likely to be divorced/widowed/separated, to have primary depression, and to have a history of medical illness, particularly cardiovascular disease or cancer. There was no difference in the generally low levels of pharmacotherapy prescribed during the index episode or the subsequent well interval.
  
  
  CONCLUSIONS
  Elderly patients with MDD may have a greater risk of recurrence than younger individuals. Low levels of treatment characterize the somatic treatment in all the study subjects, regardless of age-group.
authors.affiliation: Brown University Medical School, Department of Psychiatry and Human Behavior, c/o Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA. Timothy_Mueller@brown.edu
authors.forename: Timothy I
authors.initials: TI
authors.lastname: Mueller
authors.forename: Robert
authors.initials: R
authors.lastname: Kohn
authors.forename: Nina
authors.initials: N
authors.lastname: Leventhal
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Leon
authors.forename: David
authors.initials: D
authors.lastname: Solomon
authors.forename: William
authors.initials: W
authors.lastname: Coryell
authors.forename: Jean
authors.initials: J
authors.lastname: Endicott
authors.forename: George S
authors.initials: GS
authors.lastname: Alexopoulos
authors.forename: Martin B
authors.initials: MB
authors.lastname: Keller
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D015331:Cohort Studies; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000188:drug therapy / Q000523:psychology*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine