Association between major depressive disorder and the -1438A/G polymorphism of the serotonin 2A receptor gene.
This study investigated the possible effect of the -1438A/G single-nucleotide polymorphism in the promoter region of the serotonin 2A receptor (5-HTR2A) gene on major depressive disorder (MDD) in a Korean population. This polymorphism was analyzed in 189 patients with MDD and in 148 unrelated healthy controls using a case-control design, which revealed a significant difference in the genotype distributions (chi(2) = 10.78, d.f. = 2, p = 0.005). The frequency of the -1438G allele was also much higher in MDD patients than in normal controls (chi(2) = 7.20, p = 0.007; OR = 1.52, 95% CI 1.12-2.06). We also found significantly more carriers of the G allele (GG+AG genotypes) in MDD patients than in normal controls (chi(2) = 10.18, p = 0.001; OR = 2.46, 95% CI 1.40-4.32). Our results support the hypothesis that the -1438A/G polymorphism of the promoter region of the 5-HTR2A gene is associated with MDD patients in a Korean population.
Choi
Myoung-Jin
MJ
Department of Psychiatry, Korea University College of Medicine, Seoul, Korea.
Lee
Heon-Jeong
HJ
Lee
Hye-Jin
HJ
Ham
Byung-Joo
BJ
Cha
Ji-Hyun
JH
Ryu
Seung-Ho
SH
Lee
Min-Soo
MS
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D004252:DNA Mutational Analysis; D003865:Major Depressive Disorder / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D021122:Protein Subunits / Q000235:genetics; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics*
D021122:Protein Subunits; D044402:Receptor, Serotonin, 5-HT2A