Asymmetric hydrocyanation of hydrazones catalyzed by lanthanide--PYBOX complexes.
[reaction: see text] The asymmetric addition of HCN to hydrazones is catalyzed in high yield and good-to-excellent enantioselectivity by the easily prepared (PhPYBOX)ErCl3 complex. This constitutes the first example of asymmetric catalytic hydrocyanation of hydrazones.
Keith
John M
JM
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Jacobsen
Eric N
EN
D002384:Catalysis; D006835:Hydrazones / Q000737:chemistry*; D006856:Hydrogen Cyanide / Q000737:chemistry*; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D015394:Molecular Structure
D006835:Hydrazones; D028581:Lanthanoid Series Elements; D006856:Hydrogen Cyanide