title: Synthesis of heparin oligosaccharides.
abstract: An efficient preparation of rare 2-O-benzoyl-3-O-benzyl-1,6-anhydro-beta-l-idopyranose from commercially available diacetone alpha-d-glucose in five straightforward steps is described here. With this key building block in hand, the total syntheses of heparin oligosaccharides with three, five, seven, and nine sugar units are successfully carried out.
authors.affiliation: Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan.
authors.forename: Jinq-Chyi
authors.initials: JC
authors.lastname: Lee
authors.forename: Xin-An
authors.initials: XA
authors.lastname: Lu
authors.forename: Suvarn S
authors.initials: SS
authors.lastname: Kulkarni
authors.forename: Yuh-Sheng
authors.initials: YS
authors.lastname: Wen
authors.forename: Shang-Cheng
authors.initials: SC
authors.lastname: Hung
mesh_terms: D006027:Glycosides / Q000138:chemical synthesis / Q000737:chemistry; D006493:Heparin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D009844:Oligosaccharides / Q000138:chemical synthesis*
chemical_list: D006027:Glycosides; D009844:Oligosaccharides; D006493:Heparin