[The Hanssen method for measurement of single glomerular filtration rate].
The human renal function is usually obtained as the sum of filtration of 2 million glomeruli in both kidneys. Different glomerular size in the deep and superficial renal cortex led physiologists to suspect differences in both filtration rates and regulation. From 1955 to 1963, a young Norwegian physician, Odd E. Hanssen (1917-64) in the department of pathological anatomy at Rikshospitalet University hospital in Oslo developed a method for estimating single glomerular filtration rate in all layers of the renal cortex of experimental animals by determining tubular content of filtered ferrocyanide. When testing the method he also made several new observations on tubular functions. After a delay of several years, the "Hanssen method" was adopted in 17 laboratories around the world. In about 50 publications the filtration distribution was described in many species under control conditions, during varying salt intake, and during exposure to various nervous and humoral stimuli. Odd Hanssen did not live to see the widespread use of his method; he died from cerebral haemorrhage in 1964 at the age of 47.
Aukland
Knut
K
Fysiologisk institutt, Universitetet i Bergen, 5009 Bergen. knut.aukland@fys.uib.no
D005295:Ferrocyanides; D005919:Glomerular Filtration Rate; D049673:History, 20th Century; D006801:Humans; D008297:Male; D009398:Nephrology / Q000266:history*; D009664:Norway; D010827:Physiology / Q000266:history*
D005295:Ferrocyanides