title: NGF deprivation-induced gene expression: after ten years, where do we stand?
abstract: Nerve growth factor (NGF) is required for the survival of developing sympathetic and sensory neurons. In the absence of NGF, these neurons undergo protein synthesis-dependent apoptosis. Ten years have gone by since the first reports of specific genes being upregulated during NGF deprivation-induced cell death. Over the last decade, a few additional genes (DP5, Bim, SM-20) have been added to a list that began with cyclin D1 and c-jun. In this chapter, we discuss the evidence that these genes act as regulators of neuronal cell death. We also suggest a hypothesis for how one gene, SM-20, may function to suppress a self-protection mechanism in NGF-deprived neurons.
authors.affiliation: Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA. Robert_Freeman@urmc.rochester.edu
authors.forename: Robert S
authors.initials: RS
authors.lastname: Freeman
authors.forename: Robert L
authors.initials: RL
authors.lastname: Burch
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Crowder
authors.forename: David J
authors.initials: DJ
authors.lastname: Lomb
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Schoell
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Straub
authors.forename: Liang
authors.initials: L
authors.lastname: Xie
mesh_terms: D000818:Animals; D051017:Apoptosis Regulatory Proteins; D016923:Cell Death / Q000502:physiology*; D002455:Cell Division; D002470:Cell Survival / Q000502:physiology; D002478:Cells, Cultured; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D004268:DNA-Binding Proteins; D049308:Dioxygenases; D015870:Gene Expression / Q000502:physiology*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D006900:Hydroxylation; D064799:Hypoxia-Inducible Factor-Proline Dioxygenases; D017874:Immediate-Early Proteins / Q000235:genetics / Q000378:metabolism; D007150:Immunohistochemistry; D009414:Nerve Growth Factors / Q000172:deficiency* / Q000266:history / Q000502:physiology; D009474:Neurons / Q000166:cytology*; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism; D011393:Procollagen-Proline Dioxygenase / Q000737:chemistry / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D016755:Proto-Oncogene Proteins c-jun / Q000235:genetics / Q000378:metabolism
chemical_list: D051017:Apoptosis Regulatory Proteins; C474007:Bax protein (53-86); D004268:DNA-Binding Proteins; C484586:HRK protein, human; C484585:Hrk protein, rat; D017874:Immediate-Early Proteins; D009414:Nerve Growth Factors; D009479:Neuropeptides; D009687:Nuclear Proteins; D010446:Peptide Fragments; D011518:Proto-Oncogene Proteins; D016755:Proto-Oncogene Proteins c-jun; D019938:Cyclin D1; D049308:Dioxygenases; C490190:EGLN1 protein, human; D011393:Procollagen-Proline Dioxygenase; C447780:EGLN2 protein, human; C490189:Egln1 protein, mouse; D064799:Hypoxia-Inducible Factor-Proline Dioxygenases; D018844:Cyclin-Dependent Kinases