title: Subacute infective endocarditis caused by Corynebacterium diphtheriae: a case report.
abstract: The authors report an 11-year-old boy with septicemia and subacute infective endocarditis due to toxigenic-Corynebacterium diphtheriae. The patient had underlying congenital heart disease and incomplete immunization. He presented with fever, epistaxis and congestive heart failure. He received high-dose penicillin therapy and diphtheria antitoxin with clinical improvement. While he was receiving a high dose of penicillin for 1 month he developed a generalized tonic clonic seizure. A computerized tomogram revealed intracerebral and ventricular hemorrhage. Craniotomy with blood clot removal and ventriculostomy drainage were done. He died 2 days later from brain death and cardiovascular failure.
authors.affiliation: Infectious Disease Unit, Queen Sirikit National Institute of Child Health, Bangkok, 10400, Thailand.
authors.forename: Rangsima
authors.initials: R
authors.lastname: Lolekha
authors.forename: Praon
authors.initials: P
authors.lastname: Supradish
authors.forename: Tawatchai
authors.initials: T
authors.lastname: Kirawittaya
authors.forename: Saksan
authors.initials: S
authors.lastname: Srimaharaja
authors.forename: Tawee
authors.initials: T
authors.lastname: Chotpitayasunondh
mesh_terms: D002648:Child; D003353:Corynebacterium diphtheriae / Q000302:isolation & purification*; D004165:Diphtheria / Q000209:etiology* / Q000473:pathology; D004697:Endocarditis, Bacterial / Q000382:microbiology* / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008297:Male