title: [Xenograft-related complications after filling valgus open wedge tibial osteotomy defects].
abstract: OBJECTIVE
  The purpose of this study was to assess clinical tolerance and radiological and histological changes observed after using a safe bovine xenograft (Lubboc) to fill open wedge defects after tibial osteotomy for valgisation in patients with medial femoro-tibial degeneration.
  
  
  METHODS
  Thirty-one valgus open wedge tibial osteotomies were filled with a xenograft (Lubboc) and fixed with an epiphyseal plate in 16 women and 13 men, mean age 55 years two months. All patients had medial femorotibial degeneration with genu varum. Mean varus deviation was 6 degrees.
  
  
  RESULTS
  At two years six months follow-up, five patients had developed a local complication: three cases of non-infected discharge and two infections. Among the other 26 cases, the radiographic evolution of the xenograft was similar to that described for autologous grafts but for seven cases, a lucent line persisted, isolating the graft. A biopsy was obtained in fifteen patients during the material removal procedure. Cell infiltration was absent in nine grafts.
  
  
  CONCLUSIONS
  In light of the large number of local complications and the unpredictable nature of the radiological and histological outcome xenografting should be discontinued.
authors.affiliation: Service de Chirurgie Orthopédique et Traumatologique I, Hôpital G. Montpied, CHU de Clermont Ferrand, BP 69, 63003 Clermont-Ferrand 1. jplevai@chu-clermontferrand.fr
authors.forename: J-P
authors.initials: JP
authors.lastname: Levai
authors.forename: O
authors.initials: O
authors.lastname: Bringer
authors.forename: S
authors.initials: S
authors.lastname: Descamps
authors.forename: S
authors.initials: S
authors.lastname: Boisgard
mesh_terms: D001672:Biocompatible Materials / Q000009:adverse effects*; D016025:Bone Transplantation / Q000009:adverse effects*; D001842:Bone and Bones; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000175:diagnosis / Q000601:surgery*; D010027:Osteotomy / Q000379:methods*; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology
chemical_list: D001672:Biocompatible Materials; C093901:Lubboc