The GGA proteins: adaptors on the move.
The GGA proteins are a family of ubiquitously expressed, Arf-dependent clathrin adaptors that mediate the sorting of mannose-6-phosphate receptors between the trans-Golgi network and endosomes. Recent studies have elucidated the biochemical and structural bases for the interaction of the GGA proteins with many binding partners, and have shed light on the molecular and cellular mechanisms by which the GGA proteins participate in protein sorting.
Bonifacino
Juan S
JS
Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Building 18T/Room 101, National Institutes of Health, Bethesda, Maryland 20892, USA. juan@helix.nih.gov
D020727:ADP-Ribosylation Factors / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D033942:Adaptor Proteins, Vesicular Transport; D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002352:Carrier Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D011992:Endosomes / Q000502:physiology; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D021381:Protein Transport; D017527:Receptor, IGF Type 2 / Q000502:physiology; D012441:Saccharomyces cerevisiae / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D021601:trans-Golgi Network / Q000502:physiology
D033942:Adaptor Proteins, Vesicular Transport; D002352:Carrier Proteins; C407306:GGA adaptor proteins; D017527:Receptor, IGF Type 2; D020727:ADP-Ribosylation Factors