title: Prevention and genetic testing for breast cancer: variations in medical decisions.
abstract: The discovery linking the genes BRCA1&2 to familial breast cancer played an important role in the clinical practice of geneticists and physicians. The availability of genetic tests for BRCA gene mutations prompted cancer geneticists to give information about genetic risk and to assess many women with a personal or family history of breast or ovarian cancer to inform them of preventive measures. These consist mainly of breast self-examination, mammography screening, chemoprevention and prophylactic surgery (mastectomy, oophorectomy). This paper examines clinical practices related to hereditary breast cancer testing and introduces a number of results from a survey carried out, between 1996 and 1998, in three clinics located in Montreal (Quebec, Canada), Marseilles (France) and Manchester (Great Britain). Results show substantial differences in the way cancer geneticists deal with environmental risk factors, breast and ovarian cancer testing, and chemoprevention and prophylactic surgery. Differences across cities persist in the multivariate analysis, suggesting that attitudes towards preventive measures may be partially explained by cultural factors. Different dimensions of culture are discussed including the social representation of health and risk, the interpretation of scientific evidence and the role of innovation leadership.
authors.affiliation: Sociology and Population Health Institute, University of Ottawa, 1 Stewart, Ottawa, ON, Canada K1N 6N5. louiseb@uottawa.ca
authors.forename: Louise
authors.initials: L
authors.lastname: Bouchard
authors.forename: I
authors.initials: I
authors.lastname: Blancquaert
authors.forename: F
authors.initials: F
authors.lastname: Eisinger
authors.forename: W D
authors.initials: WD
authors.lastname: Foulkes
authors.forename: G
authors.initials: G
authors.lastname: Evans
authors.forename: H
authors.initials: H
authors.lastname: Sobol
authors.forename: C
authors.initials: C
authors.lastname: Julian-Reynier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics* / Q000517:prevention & control*; D016504:Breast Self-Examination; D018890:Chemoprevention; D003657:Decision Making; D005260:Female; D005602:France; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008327:Mammography; D008408:Mastectomy; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000235:genetics / Q000517:prevention & control / Q000628:therapy; D010052:Ovariectomy; D010817:Physician-Patient Relations; D011322:Primary Prevention / Q000379:methods; D011792:Quebec; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D006113:United Kingdom