The role of eosinophils in host defense against helminth parasites.
The precise function of eosinophils in parasitic infection in vivo remains poorly understood despite eosinophils having been shown to be potent effectors in killing parasites in vitro. Although it has long been held that the primary function of the eosinophil is protection against helminth parasites, there are little data to prove this unequivocally. Moreover, eosinophils are responsible for a considerable amount of inflammatory pathology accompanying helminth infections. This article will provide an overview of our current knowledge about eosinophils and their role, both protective and pathogenetic, in parasitic helminth infections.
Klion
Amy D
AD
Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
Nutman
Thomas B
TB
D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D004195:Disease Models, Animal; D004804:Eosinophils / Q000502:physiology*; D006373:Helminthiasis / Q000097:blood / Q000276:immunology* / Q000469:parasitology; D006376:Helminths / Q000276:immunology*; D006801:Humans; D007109:Immunity; D015848:Interleukin-5 / Q000097:blood / Q000502:physiology; D051379:Mice
D000909:Antibodies, Helminth; D015848:Interleukin-5