title: Nucleolar proteins that bind NLSs: a role in nuclear import or ribosome biogenesis?
abstract: In a search for proteins that bind nuclear localization sequences (NLSs), a number of nucleolar proteins with diverse functions were found. It is thought that the assay fortuitously uncovered a novel domain that mediates the interaction between these nucleolar proteins and ribosomal proteins containing NLS-like sequences. The domain is highly acidic and contains a number of serines forming putative casein kinase II sites. Here, we propose a model in which the nucleolar proteins catalyse the assembly of ribosomal proteins with pre-rRNA.
authors.affiliation: Department of Biological Sciences, Columbia University, 702 Fairchild Building, New York, NY 10027, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Xue
authors.forename: T
authors.initials: T
authors.lastname: Mélèse