title: Attenuated response to stress and novelty and hypersensitivity to seizures in 5-HT4 receptor knock-out mice.
abstract: To study the functions of 5-HT4 receptors, a null mutation was engineered in the corresponding gene. 5-HT4 receptor knock-out mice displayed normal feeding and motor behaviors in baseline conditions but abnormal feeding and locomotor behavior in response to stress and novelty. Specifically, stress-induced hypophagia and novelty-induced exploratory activity were attenuated in the knock-out mice. In addition, pentylenetetrazol-induced convulsive responses were enhanced in the knock-out mice, suggesting an increase in neuronal network excitability. These results provide the first example of a genetic deficit that disrupts the ability of stress to reduce feeding and body weight and suggest that 5-HT4 receptors may be involved in stress-induced anorexia and seizure susceptibility.
authors.affiliation: Unité Propre de Recherche Centre National de la Recherche Scientifique 2580, Génomique fonctionnelle, Montpellier 34094, France. Valerie.Compan@ccipe.cnrs.fr
authors.forename: Valérie
authors.initials: V
authors.lastname: Compan
authors.forename: Mingming
authors.initials: M
authors.lastname: Zhou
authors.forename: Régis
authors.initials: R
authors.lastname: Grailhe
authors.forename: Russell A
authors.initials: RA
authors.lastname: Gazzara
authors.forename: Renee
authors.initials: R
authors.lastname: Martin
authors.forename: Jay
authors.initials: J
authors.lastname: Gingrich
authors.forename: Aline
authors.initials: A
authors.lastname: Dumuis
authors.forename: Daniela
authors.initials: D
authors.lastname: Brunner
authors.forename: Joël
authors.initials: J
authors.lastname: Bockaert
authors.forename: René
authors.initials: R
authors.lastname: Hen
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001835:Body Weight; D003292:Convulsants; D004435:Eating; D004777:Environment; D018390:Gene Targeting; D008124:Locomotion; D051379:Mice; D018345:Mice, Knockout; D009415:Nerve Net / Q000503:physiopathology; D010433:Pentylenetetrazole; D044422:Receptors, Serotonin, 5-HT4 / Q000235:genetics / Q000502:physiology*; D012640:Seizures / Q000139:chemically induced / Q000209:etiology* / Q000503:physiopathology; D013312:Stress, Physiological / Q000150:complications*
chemical_list: D003292:Convulsants; D044422:Receptors, Serotonin, 5-HT4; D010433:Pentylenetetrazole