[Radionuclide reporter gene imaging].
Molecular nuclear imaging techniques are currently being developed to map the topography and level of gene expression following gene therapy. To date, two radionuclide-based imaging strategies have been investigated--using reporter genes encoding either intracellular enzymes or cell-surface receptors. In this article, we discuss these two reporter gene imaging systems that have been developed to detect gene expression noninvasively.
Zhang
Zhen-wei
ZW
Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. zwzhang@sibs.ac.cn
Zhang
Xue-mei
XM
Wu
Hua
H
D005786:Gene Expression Regulation; D018014:Gene Transfer Techniques; D017930:Genes, Reporter / Q000235:genetics*; D041722:Genes, Transgenic, Suicide / Q000235:genetics; D015316:Genetic Therapy; D005822:Genetic Vectors; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008967:Molecular Biology; D011877:Radionuclide Imaging; D014162:Transfection