title: Left atrial function as a predictor of haemodynamic response in patients with mitral stenosis: a dobutamine stress echocardiographic study.
abstract: OBJECTIVE
  The mechanisms of the different haemodynamic and clinical responses to dobutamine infusion in mitral stenosis (MS) are not clearly established. The aim of this study was to evaluate the relation between left atrial (LA) function and haemodynamic response in patients with MS during dobutamine infusion.
  
  
  RESULTS
  Forty-two consecutive moderately symptomatic patients (33 women, 9 men; mean age 46+/-9, range from 26 to 66), New York Heart Association (NYHA) class II with MS (mean mitral valve area 1.7+/-0.1 cm2) were evaluated with dobutamine stress echocardiography. Haemodynamic measurements were obtained at rest and during peak dobutamine infusion. LA fractional shortening at rest was used as an index of global LA function. Group I consisting of patients with significantly elevated pulmonary artery pressure (> 60 mm Hg) and mean transmitral gradient (> 15 mm Hg) at peak dobutamine infusion were defined as haemodynamically serious MS. Group II consisted of the remaining 30 patients whose haemodynamic data were below these levels. While baseline haemodynamic parameters and mitral valve characteristics were not different between the two groups, LA fractional shortening was significantly lower (18.9+/-2.8 vs. 32.3+/-5.1%, p<0.0001) and left atrial dimension was significantly larger in group I (49.7+/-2.3 mm vs 43.6+/-5.3 mm, p<0.0001). Left atrial fractional shortening was negatively correlated with the increase in mean transmitral gradient (r:-0.58, p<0.01). When the patients were divided using a LA fractional shortening level of 25% as the cut-off point, we observed that the patients with low LA fractional shortening had a greater increase in mean transmitral gradient (7.3+/-3.1 mm Hg vs. 4.6+/-1.4 mm Hg), p = 0.005) and pulmonary artery pressure (22.4+/-3.5 mm Hg vs. 16.1+/-8.5 mm Hg, p = 0.001) compared to the patients with high LA fractional shortening. Based on these haemodynamic results, management was changed in 12 patients (28%): 5 underwent percutaneous mitral balloon commissurotomy and 7 received intensive medical treatment.
  
  
  CONCLUSIONS
  The present study demonstrates that haemodynamic response during dobutamine stress echocardiography correlates with LA fractional shortening in patients with MS. The evaluation of left atrial function at rest in patients with ambiguous symptoms and mild mitral stenosis may be useful in clinical decision making. Atrial dysfunction at rest may predict the haemodynamic response during stress echo in these patients.
authors.affiliation: Akdeniz University Department of Cardiology, Antalya, Turkey. aybel68@hotmail.com
authors.forename: Aytül
authors.initials: A
authors.lastname: Belgi
authors.forename: Selim
authors.initials: S
authors.lastname: Yalçinkaya
authors.forename: Seyhan
authors.initials: S
authors.lastname: Cetin
authors.forename: Mehmet
authors.initials: M
authors.lastname: Kabukçu
authors.forename: Ilhan
authors.initials: I
authors.lastname: Gölbaşi
authors.forename: Oktay
authors.initials: O
authors.lastname: Sancaktar
mesh_terms: D000318:Adrenergic beta-Agonists / Q000008:administration & dosage; D000328:Adult; D000368:Aged; D016279:Atrial Function, Left / Q000502:physiology*; D004280:Dobutamine / Q000008:administration & dosage; D025401:Echocardiography, Stress; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008946:Mitral Valve Stenosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011669:Pulmonary Wedge Pressure / Q000187:drug effects / Q000502:physiology; D012720:Severity of Illness Index; D013223:Statistics as Topic; D013599:Systole / Q000187:drug effects / Q000502:physiology
chemical_list: D000318:Adrenergic beta-Agonists; D004280:Dobutamine