title: No T without D3: a critical role for cyclin D3 in normal and malignant precursor T cells.
abstract: A definitive knockout reported in this issue of Cancer Cell by Sicinska et al. reveals an unsuspected role for cyclin D3 in normal T cell development and suggests new therapeutic possibilities in precursor T cell leukemia.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA. aweng@partners.org
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Weng
authors.forename: Jon C
authors.initials: JC
authors.lastname: Aster
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D002454:Cell Differentiation; D056743:Cyclin D3; D016213:Cyclins / Q000378:metabolism*; D006801:Humans; D015458:Leukemia, T-Cell / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism*
chemical_list: C534696:CCND3 protein, human; D056743:Cyclin D3; D016213:Cyclins