title: The influence of moisture wound healing on the incidence of bacterial infection and histological changes in healthy human skin after treatment of interactive dressings.
abstract: In this article the authors discuss the problem faced by physicians when trying to use moisture-retentive dressing in pressure sores (decubitus ulcers). First, they report the results of an in vitro study using a new model of experimental wound (radio-isotopic investigation) that assesses the release of Ringer's solution from interactive dressings continually during fourteen hours. Second, they perform an animal experiment that assesses the incidence of wound infection in defects treated conventionally or using interactive dressings. The defects treated with interactive pads had lower incidence of wound infection, and the process of wound healing was rapid. Finally, the authors discuss their experience in four paraplegic patients with decubitus ulcers where they used moisture-retentive dressing on ulcers and on the surrounding intact skin before surgical procedure to detect the possibility of maceration of healthy skin. Histological evaluation was performed in order to find microscopically changes after moisture healing. The changes of healthy skin were not significant after treatment of moisture-retentive dressings.
authors.affiliation: Department of Burns and Reconstructive Surgery, University Hospital Brno, Czech Republic. jkoupil@fnbrno.cz
authors.forename: J
authors.initials: J
authors.lastname: Koupil
authors.forename: P
authors.initials: P
authors.lastname: Brychta
authors.forename: D
authors.initials: D
authors.lastname: Horký
authors.forename: J
authors.initials: J
authors.lastname: Smola
authors.forename: J
authors.initials: J
authors.lastname: Prásek
mesh_terms: D000368:Aged; D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D015994:Incidence; D007552:Isotonic Solutions; D009779:Occlusive Dressings; D003668:Pressure Ulcer / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D011446:Prospective Studies; D000077331:Ringer's Solution; D013552:Swine; D014945:Wound Healing; D014946:Wound Infection / Q000517:prevention & control*
chemical_list: D007552:Isotonic Solutions; D000077331:Ringer's Solution