The discovery that xeroderma pigmentosum (XP) results from defective nucleotide excision repair.
Most forms of the human hereditary disease xeroderma pigmentosum (XP) are due to a defect in nucleotide excision repair of DNA damage in skin cells associated with exposure to sunlight. This discovery by James Cleaver had an important impact on our understanding of nucleotide excision repair in mammals.
Friedberg
Errol C
EC
Laboratory of Molecular Pathology, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, 75390-9072, USA. friedberg.errol@pathology.swmed.edu
D004249:DNA Damage; D004260:DNA Repair; D004273:DNA, Neoplasm / Q000528:radiation effects; D005823:Genetics / Q000266:history; D049673:History, 20th Century; D006801:Humans; D012867:Skin / Q000528:radiation effects; D012878:Skin Neoplasms / Q000235:genetics / Q000266:history*; D013472:Sunlight / Q000009:adverse effects; D014983:Xeroderma Pigmentosum / Q000235:genetics / Q000266:history*
D004273:DNA, Neoplasm