Cerebellar metabolite alterations detected in vivo by proton MR spectroscopy.
The aim of our work was to evaluate the feasibility of in vivo single-voxel quantitative proton MR spectroscopy in order to identify possible alterations in the main metabolite concentrations due to some metabolic dysfunctions in the cerebellum of patients suffering from a particular form of migraine called "with aura." Measurements of metabolite levels in the cerebellum disclosed reduced choline values (normalized both to N-acetyl-aspartate and creatine) in the patient group with respect to the age-matched control group. Our interest in this pathology is motivated by the fact that there are no available specific biochemical markers for migraine characterization, and the current diagnostic only takes advantage of the medical history and the clinical examination.
Macrì
M A
MA
Dipartimento di Medicina Sperimentale e Patologia, Università, La Sapienza, di Roma, Rome, Italy.
Garreffa
G
G
Giove
F
F
Ambrosini
A
A
Guardati
M
M
Pierelli
F
F
Schoenen
J
J
Colonnese
C
C
Maraviglia
B
B
D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D001923:Brain Chemistry; D016022:Case-Control Studies; D002531:Cerebellum / Q000378:metabolism*; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D020325:Migraine with Aura / Q000175:diagnosis*; D011522:Protons
D011522:Protons; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline