Production of chitosan pellets by extrusion/spheronization.
Chitosan pellets were successfully prepared using the extrusion/spheronization technology. Microcrystalline cellulose was used as additive in concentrations from 70 to 0%. The powder mixtures were extruded using water and diluted acetic acid solution in different powder to liquid ratios. The effects on bead formation using water and different acetic acid concentrations and solution quantities were analysed. Also, the morphological and mechanical characteristics of the obtained beads were investigated. With demineralized water as granulation fluid, pellets with a maximum of 50% (m/m) of chitosan could be produced. The mass fraction of chitosan within the pellets could be increased to 100% by using diluted acetic acid for the granulation step.
Steckel
H
H
Department of Pharmaceutics and Biopharmaceutics, Christian Albrecht University Kiel, Kiel, Germany. steckel@pharmazie.uni-kiel.de
Mindermann-Nogly
F
F
D019342:Acetic Acid / Q000737:chemistry; D002482:Cellulose / Q000138:chemical synthesis / Q000737:chemistry; D048271:Chitosan / Q000138:chemical synthesis* / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004339:Drug Compounding / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods; D004343:Drug Implants / Q000138:chemical synthesis* / Q000737:chemistry; D005079:Excipients / Q000138:chemical synthesis / Q000737:chemistry; D006244:Hardness / Q000187:drug effects; D010316:Particle Size; D011109:Polymethacrylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D016062:Porosity / Q000187:drug effects; D011208:Powders / Q000737:chemistry; D013499:Surface Properties / Q000187:drug effects; D014867:Water / Q000737:chemistry
D004337:Drug Carriers; D004343:Drug Implants; D005079:Excipients; D011109:Polymethacrylic Acids; D011208:Powders; D014867:Water; C012553:spherons; D002482:Cellulose; D048271:Chitosan; C109691:microcrystalline cellulose; D019342:Acetic Acid