Pancytopenia due to suppressed hematopoiesis in a case of fatal hemolytic disease of the newborn associated with anti-K supported by molecular K1 typing.
The authors report on a fatal case of hemolytic disease of the newborn (HDN) due to anti-K antibodies with subsequent trilineage pancytopenia in a preterm infant of 28 weeks gestational age, with pronounced leukopenia and neutropenia. In addition, molecular typing of the Kk polymorphism was necessary to confirm HDN. This case of HDN associated with anti-K provides additional evidence that trilineage pancytopenia due to suppressed hematopoiesis is part of the disease. Therefore, antibodies against antigens of the Kell blood group system should be considered as a potential cause of unexplained inhibition of myelopoiesis.
Wagner
Thomas
T
Department of Blood Group Serology and Transfusion Medicine, Pediatric Department, University of Graz, Austria. thomas.wagner@uni-graz.at
Resch
Bernhard
B
Reiterer
Friedrich
F
Gassner
Christoph
C
Lanzer
Gerhard
G
D000328:Adult; D001323:Autoantibodies; D004899:Erythroblastosis, Fetal / Q000276:immunology*; D017809:Fatal Outcome; D005260:Female; D005838:Genotype; D006410:Hematopoiesis / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007626:Kell Blood-Group System / Q000235:genetics / Q000276:immunology*; D010198:Pancytopenia / Q000209:etiology*; D011110:Polymorphism, Genetic; D011247:Pregnancy
D001323:Autoantibodies; D007626:Kell Blood-Group System