title: Renal cholesterol embolic disease effectively treated with steroid pulse therapy.
abstract: A 65-year-old man developed acute renal failure with eosinophilia two weeks after a coronary bypass operation and angiography. Renal biopsy revealed cholesterol crystal embolism (CCE) in glomeruli and arterioles. Low-dose corticosteroid therapy failed to recover the renal function; further deterioration of renal function and peripheral ischemic symptoms such as livedo reticularis and blue toes occurred. However, steroid pulse therapy successfully attenuated CCE-induced renal failure and eosinophilia. It is suggested that steroid pulse therapy might be effective to treat CCE-induced renal failure and eosinophilia could be a useful marker for activity of CCE.
authors.affiliation: First Department of Internal Medicine, Yamagata University School of Medicine, Yamagata.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takahashi
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Konta
authors.forename: Wakako
authors.initials: W
authors.lastname: Nishida
authors.forename: Akira
authors.initials: A
authors.lastname: Igarashi
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Ichikawa
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
mesh_terms: D000368:Aged; D017700:Embolism, Cholesterol / Q000188:drug therapy* / Q000473:pathology; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy* / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage*; D020551:Pulse Therapy, Drug
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone