Trypanocidal constituents in plants 3. Leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense.
The constituents of the leaves of Garcinia intermedia and heartwood of Calophyllum brasiliense were investigated based on their trypanocidal activity against epimastigotes of Trypanosoma cruzi, the etiologic agent of Chagas' disease. As the active components, the polyisoprenylated benzophenone derivative guttiferone A and the xanthone 8-desoxygartanin were isolated along with the biflavonoids podocarpusflavone A and amentoflavone, and friedelin from the former. Three xanthones, jacareubin, 6-deoxyjacareubin, and 1,3,5,6-tetrahydroxy-2-(3-methyl-2-butenyl)xanthone from the latter showed activity. The trypanocidal activity of these compounds against trypomastigotes, an infectious form of T. cruzi, was examined as well as gossypol, berberine chloride, and harmine for comparison.
Abe
Fumiko
F
Faculty of Pharmaceutical Sciences, School of Medicine, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan. abefumi@fukuoka-u.ac.jp
Nagafuji
Shinya
S
Okabe
Hikaru
H
Akahane
Hiroshige
H
Estrada-Muñiz
Elizabeth
E
Huerta-Reyes
Maira
M
Reyes-Chilpa
Ricardo
R
D000818:Animals; D001599:Berberine / Q000494:pharmacology; D029759:Calophyllum / Q000737:chemistry*; D029760:Garcinia / Q000737:chemistry*; D006072:Gossypol / Q000494:pharmacology; D006247:Harmine / Q000494:pharmacology; D007202:Indicators and Reagents; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D014344:Trypanocidal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects; D014934:Wood
D007202:Indicators and Reagents; D010936:Plant Extracts; D014344:Trypanocidal Agents; D001599:Berberine; D006247:Harmine; D006072:Gossypol