title: Diffusion-weighted MRI and ADC mapping in FK506 neurotoxicity.
abstract: FK506 is a newly developed potent immunosuppressant for preventing rejection after organ transplantation. However, FK506 can induce central nervous system toxicity. Until now the pathogenic mechanism of FK506 neurotoxicity was unclear. We report the findings of diffusion-weighted MRI and apparent diffusion coefficient (ADC) mapping of a FK506 neurotoxicity patient who showed increased signal intensities in both parieto-occipital lobes on T(2) weighted images, diffusion-weighted images and ADC maps. These findings suggest that a vasogenic oedema rather than a cytotoxic oedema may play a pivotal role in FK506 neurotoxicity pathogenesis.
authors.affiliation: Department of Diagnostic Radiology, The Catholic University of Korea, Seoul, Korea.
authors.forename: K J
authors.initials: KJ
authors.lastname: Ahn
authors.forename: J W
authors.initials: JW
authors.lastname: Lee
authors.forename: S T
authors.initials: ST
authors.lastname: Hahn
authors.forename: D W
authors.initials: DW
authors.lastname: Yang
authors.forename: P S
authors.initials: PS
authors.lastname: Kim
authors.forename: H J
authors.initials: HJ
authors.lastname: Kim
authors.forename: C C
authors.initials: CC
authors.lastname: Kim
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D016026:Bone Marrow Transplantation; D001929:Brain Edema / Q000139:chemically induced* / Q000175:diagnosis; D001931:Brain Mapping / Q000379:methods; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D016559:Tacrolimus / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus