title: HIV type 1 diversity in northeastern Romania in 200-2001 based on phylogenic analysis of pol sequences from patient failing antiretroviral therapy.
abstract: Protease and the first half of reverse transcriptase from 71 Romanian patients failing highly active antiretroviral therapy (HAART) have been sequenced and phylogenetically analyzed. These analyses show that 70 patients were infected with subtype F1 and one with subtype C. The pattern of drug resistance mutations in subtype F1-infected patients failing HAART is similar to that described for subtype B strains. These results show that the diversity pattern of HIV type 1 infection in Romania has remained steady over a decade, with subtype F1 remaining the predominant viral form. The circulation of subtype F1 in Romania has the potential to be a source of this HIV-1 subtype in Europe..
authors.affiliation: Virology Laboratory, Pathology Laboratory and Infectious diseases Clinic, School of Medicine, Gr. T. Popa University of Iasi, Romania. cristiana@tpc.tulane.edu
authors.forename: Cristian
authors.initials: C
authors.lastname: Apetrei
authors.forename: Diane
authors.initials: D
authors.lastname: Descamps
authors.forename: Gilles
authors.initials: G
authors.lastname: Collin
authors.forename: David L
authors.initials: DL
authors.lastname: Robertson
authors.forename: Ivona
authors.initials: I
authors.lastname: Pandrea
authors.forename: Petru
authors.initials: P
authors.lastname: Groza
authors.forename: Liviu
authors.initials: L
authors.lastname: Prisecariu
authors.forename: Irina
authors.initials: I
authors.lastname: Teodorescu
authors.forename: Vasile
authors.initials: V
authors.lastname: Luca
authors.forename: Françoise
authors.initials: F
authors.lastname: Brun-Vézinet
mesh_terms: D000293:Adolescent; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D024882:Drug Resistance, Viral / Q000235:genetics*; D015684:Gene Products, pol / Q000235:genetics*; D014644:Genetic Variation; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D015995:Prevalence; D012383:Romania; D019562:Viral Load; D054302:pol Gene Products, Human Immunodeficiency Virus
chemical_list: D015684:Gene Products, pol; C060467:HIV pol protein p65; D054302:pol Gene Products, Human Immunodeficiency Virus