title: Long-term results after surgical extraction of subfoveal choroidal neovascular membranes with and without haemorrhage in age-related macular degeneration.
abstract: BACKGROUND
  Surgical extraction has been suggested as a treatment of choroidal neovascular membranes. We demonstrate the long-term results of our patients regarding complications, risk of recurrence and development of visual acuity.
  
  
  METHODS
  We have retrospectively evaluated the charts and re-examined the patients who underwent surgical extraction of choroidal neovascular membranes (CNV) because of age-related macular degeneration (AMD) between March 1994 and December 2000 in the Department of Ophthalmology of the Benjamin Franklin Clinic, Berlin. Fifty-two eyes of 49 patients with a minimum follow-up of 12 months after pars plana vitrectomy with CNV extraction and SF6-endotamponade were included. Initially, in 15% of all eyes the lesions were obscured by intravitreal haemorrhage. All visible lesions were located subfoveally. In 40% of all eyes the lesion was predominantly classic; 21% of the lesions were predominantly occult and 23% of the lesions were comprised of more than 50% haemorrhage. The maximum follow-up was 80 months, the mean 46 months.
  
  
  RESULTS
  The median initial visual acuity was 0.08 (range: hand movements to 0.4) and the median final visual acuity was not significantly different at 0.067 (range: non lux to 0.4). A loss of less than three lines of visual acuity occurred in 65.4% of our patients. During follow-up, 25% of eyes developed a rhegmatogenous retinal detachment and 19.2% of all eyes suffered from recurrence of CNV. At the end of the follow-up, three eyes (5.8%) suffered from non-treated retinal detachment and three eyes (5.8%) had recurrent CNV lesions. All eyes showed a retinal pigment epithelium defect at the site of former CNV.
  
  
  CONCLUSIONS
  A stabilisation of visual acuity in individual patients with CNV because of AMD can be achieved by surgical extraction, yet the defect of the RPE and the risk of complications limit the benefit. We consider the surgical extraction of CNV from AMD in patients with low initial visual acuity who are not amenable to PDT.
authors.affiliation: Augenklinik, Charité Universitätsmedizin Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany. Agabel@zedat.fu-berlin.de
authors.forename: Ameli
authors.initials: A
authors.lastname: Gabel-Pfisterer
authors.forename: Jessica
authors.initials: J
authors.lastname: Laue
authors.forename: Heinrich
authors.initials: H
authors.lastname: Heimann
authors.forename: Claudia
authors.initials: C
authors.lastname: Jandeck
authors.forename: Ulrich
authors.initials: U
authors.lastname: Kellner
authors.forename: Norbert
authors.initials: N
authors.lastname: Bornfeld
authors.forename: Michael H
authors.initials: MH
authors.lastname: Foerster
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000209:etiology / Q000601:surgery*; D005260:Female; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D005584:Fovea Centralis; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000601:surgery*; D008297:Male; D008566:Membranes / Q000601:surgery; D008875:Middle Aged; D011379:Prognosis; D012008:Recurrence; D012166:Retinal Hemorrhage / Q000150:complications / Q000601:surgery*; D012189:Retrospective Studies; D013459:Sulfur Hexafluoride / Q000008:administration & dosage; D014792:Visual Acuity; D014821:Vitrectomy
chemical_list: D013459:Sulfur Hexafluoride