Old drugs, new tricks: using genetically sensitized yeast to reveal drug targets.
A study in this issue of Cell illustrates the power of applying genomic approaches with model systems to characterize the biological activity of small molecules and to identify their cellular targets, which can clarify the mode of action of human therapeutics.
Hughes
Tim
T
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5G 1L6.
Andrews
Brenda
B
Boone
Charles
C
D016503:Drug Delivery Systems / Q000639:trends*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000639:trends*; D020869:Gene Expression Profiling / Q000639:trends; D016681:Genome, Fungal; D006238:Haploidy; D008954:Models, Biological; D015003:Yeasts / Q000187:drug effects* / Q000235:genetics