Signal transduction of phagocytosis.
The interaction of particles with certain cell surface receptors initiates intracellular signalling pathways that ultimately lead to submembranous actin filament assembly, pseudopod extension, and the ingestion of the particles. Here, Steven Greenberg reviews recent evidence implicating various signalling events in phagocytosis--in particular, activation of tyrosine kinases and phosphatidylinositol 3-kinase--and speculates how they might regulate the actin cytoskeleton.
Greenberg
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Dept of Medicine, Pulmonary Division, Columbia University College of Physicians & Surgeons, 630 West 168th Street, New York, NY 10032, USA.