title: The potential role of the HIV-1 immunogen (Remune) as a therapeutic vaccine in the treatment of HIV infection.
abstract: Immune-based therapies, such as therapeutic vaccination, that might preserve, restore, enhance and induce new HIV-specific immunologic responses are currently being explored. HIV-specific immunotherapy with Remune (The Immune Response Corp.) offers the opportunity to boost immune responses against HIV-1. The clinical trial program in a wide range of subjects has established the efficacy of Remune in stimulating an appropriate immune response in HIV-positive individuals. Furthermore, a recent unblinded study conducted in Europe has documented a significant effect of Remune on viral load. Evidence regarding clinical end points is more difficult to collect. The same studies have revealed no serious safety issues in a total of more than 2000 Remune-treated patients. It is therefore reasonable to suggest that the risk-benefit ratio of Remune could be positive.
authors.affiliation: University General Hospital Gregorio Marañón, Immunology Department, Complutense University of Madrid, Madrid, Spain. efernandez@inmuno.hggm.es
authors.forename: Eduardo
authors.initials: E
authors.lastname: Fernández-Cruz
authors.forename: Joaquín
authors.initials: J
authors.lastname: Navarro
authors.forename: Carmen
authors.initials: C
authors.lastname: Rodríguez-Sainz
authors.forename: Juana
authors.initials: J
authors.lastname: Gil
authors.forename: Santiago
authors.initials: S
authors.lastname: Moreno
authors.forename: Juan
authors.initials: J
authors.lastname: González-Lahoz
authors.forename: Javier
authors.initials: J
authors.lastname: Carbone
mesh_terms: D016915:AIDS Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D002986:Clinical Trials as Topic; D015658:HIV Infections / Q000276:immunology / Q000517:prevention & control*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D018570:Risk Assessment; D014611:Vaccination / Q000009:adverse effects
chemical_list: D016915:AIDS Vaccines; C105086:remune