Effects of benzyl glucoside and chlorogenic acid from Prunus mume on adrenocorticotropic hormone (ACTH) and catecholamine levels in plasma of experimental menopausal model rats.
To investigate the effectiveness of benzyl beta-D-glucopyranoside (BG) and chlorogenic acid (CA), the constituents of the fruit of Prunus mume, for relieving tension in experimental menopausal model rats (M-rats) caused by ether stress, the effects of BG and CA on adrenocorticotropic hormone (ACTH) and catecholamine (adrenaline, noradrenaline, and dopamine) levels were examined in the plasma of M-rats. Caffeic acid, quinic acid, and rosmarinic acid, which are compounds structurally related to CA, were also examined. BG obviously recovered catecholamine levels decreased by ether stress and increased dopamine to high levels. On the other hand, CA significantly decreased the ACTH level increased by ether stress and showed the greatest effect of all compounds. These results suggest that BG and CA may contribute to relieving the tension in M-rats caused by ether stress.
Ina
Hiroji
H
School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. inah@ps.toyaku.ac.jp
Yamada
Kenji
K
Matsumoto
Kosai
K
Miyazaki
Toshio
T
D000324:Adrenocorticotropic Hormone / Q000097:blood*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002109:Caffeic Acids / Q000494:pharmacology; D002395:Catecholamines / Q000097:blood*; D002726:Chlorogenic Acid / Q000302:isolation & purification / Q000494:pharmacology*; D002934:Cinnamates / Q000494:pharmacology; D053630:Depsides; D004305:Dose-Response Relationship, Drug; D005260:Female; D005638:Fruit / Q000737:chemistry; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D010052:Ovariectomy; D027861:Prunus / Q000737:chemistry*; D011801:Quinic Acid / Q000494:pharmacology; D051381:Rats; D012741:Sexual Maturation / Q000502:physiology; D013315:Stress, Psychological / Q000378:metabolism; D000097123:Rosmarinic Acid
D000324:Adrenocorticotropic Hormone; D000975:Antioxidants; D002109:Caffeic Acids; D002395:Catecholamines; D002726:Chlorogenic Acid; D002934:Cinnamates; D053630:Depsides; D005960:Glucosides; D011801:Quinic Acid; D000097123:Rosmarinic Acid; C410942:benzyl glucopyranoside; C040048:caffeic acid