title: A nosocomial outbreak of Serratia marcescens producing inducible Amp C-type beta-lactamase enzyme and carrying antimicrobial resistance genes within a class 1 integron.
abstract: We investigated an outbreak of Serratia marcescens in the adult intensive care unit of the University Hospital of Napoli. The outbreak involved 13 cases of infection by S. marcescens over a nine-month period and was caused by a single pulsed-field gel electrophoresis clone. The epidemic strain was multiply antibiotic resistant, producing an inducible Amp C-type beta-lactamase enzyme and carrying the trimethoprim-resistance gene and the adenyltransferase gene, which confers resistance to streptomycin and spectinomycin, within a class 1 integron. Antimicrobial therapy with beta-lactams was associated with S. marcescens acquisition in the intensive care unit.
authors.affiliation: Dipartimento di Scienze Mediche Preventive, Università Federico II, Napoli, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Bagattini
authors.forename: M
authors.initials: M
authors.lastname: Crispino
authors.forename: F
authors.initials: F
authors.lastname: Gentile
authors.forename: E
authors.initials: E
authors.lastname: Barretta
authors.forename: D
authors.initials: D
authors.lastname: Schiavone
authors.forename: M C
authors.initials: MC
authors.lastname: Boccia
authors.forename: M
authors.initials: M
authors.lastname: Triassi
authors.forename: R
authors.initials: R
authors.lastname: Zarrilli
mesh_terms: D000328:Adult; D001426:Bacterial Proteins; D002999:Clone Cells; D003428:Cross Infection / Q000453:epidemiology* / Q000235:genetics / Q000382:microbiology; D004196:Disease Outbreaks; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D005260:Female; D006785:Hospitals, University; D006801:Humans; D032023:Integrons / Q000235:genetics; D007362:Intensive Care Units; D007558:Italy / Q000453:epidemiology; D008297:Male; D016868:Serratia Infections / Q000453:epidemiology* / Q000235:genetics / Q000382:microbiology; D012706:Serratia marcescens / Q000201:enzymology / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; C048795:AmpC beta-lactamases; D001618:beta-Lactamases