title: Hydrolysis of N- and S-monomethyl derivatives of 2-thiophenobarbital.
abstract: Kinetics of hydrolysis of S-methyl-2-thiophenobarbital in aqueous solutions was investigated using the UV spectroscopic method within the pH range 1.5-12.9 at 60 degrees C. Chromatography was used to separate and isolate the products of hydrolysis of this compound and its N-methyl isomer. The products were identified by spectroscopic methods and the course of hydrolysis of both isomers were compared.
authors.affiliation: Department of Organic Chemistry, Medical College, Jagiellonian University, 9 Medyczna Str., 30-688 Kraków, Poland.
authors.forename: Monika
authors.initials: M
authors.lastname: Tarsa
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Zuchowski
authors.forename: Jacek
authors.initials: J
authors.lastname: Bojarşki
mesh_terms: D000465:Algorithms; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006868:Hydrolysis; D007536:Isomerism; D007700:Kinetics; D013058:Mass Spectrometry; D010634:Phenobarbital / Q000031:analogs & derivatives / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: C481455:N-methyl-2-thiophenobarbital; C481454:S-methyl-2-thiophenobarbital; D010634:Phenobarbital