title: [Study on relative bioavailability of aspirin in afenca tablet].
abstract: Salicylic acid is a kind of active metabolite of aspirin in vivo. In this study, its concentration in plasma was detected by RP-HPLC after twenty four healthy male volunteers were given each a single dose of oral Afenca test and reference preparations. The experiment data were calculated with 3P97 program. The results were analyzed by ANOVA and two- and one-sided t tests. The relative bioavailability of salicylic acid was 105.36% +/- 14.15%; AUC0-T of salicylic acid of test and reference preparations were 103.10 +/- 11.92 micrograms.h/ml and 98.45 +/- 13.49 micrograms.h/ml respectively; Tmax were 1.5 +/- 0.5 h and 1.5 +/- 0.5 h; Cmax were 19.31 +/- 2.47 micrograms/ml and 18.95 +/- 2.49 micrograms/ml. Bioequivalent evaluation of two preparations by analyzing with two- and one-sided t tests showed that the two preparations were bioequivalent on the basis of salicylic acid (t1 > or = t1-0.05(22), t2 > or = t1-0.06(22)).
authors.affiliation: School of Pharmacy, Sichuan University, Chengdu 610041.
authors.forename: Junyi
authors.initials: J
authors.lastname: Yang
authors.forename: Xuehua
authors.initials: X
authors.lastname: Jiang
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Suhua
authors.initials: S
authors.lastname: Li
authors.forename: Shu
authors.initials: S
authors.lastname: Lin
mesh_terms: D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D001241:Aspirin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D006801:Humans; D008297:Male; D020156:Salicylic Acid / Q000097:blood; D013607:Tablets; D013810:Therapeutic Equivalency
chemical_list: D013607:Tablets; D020156:Salicylic Acid; D001241:Aspirin