Impaired glucose tolerance and reduced beta-cell function in overweight Latino children with a positive family history for type 2 diabetes.
The objective of this study was to examine relationships between impaired glucose tolerance (IGT) and body composition and insulin-related phenotypes in 150 overweight Latino children with a family history of type 2 diabetes. Glucose tolerance was assessed by an oral glucose challenge. Body composition was assessed by dual energy x-ray absorptiometry and magnetic resonance imaging. Insulin sensitivity, the acute insulin response, and the disposition index (DI), as an index of beta-cell function, were determined by an iv glucose tolerance test and compared between normal glucose-tolerant and IGT children. IGT was present in 28% of children, and was similar across obesity groups, but higher in children exposed to gestational diabetes mellitus (41% IGT). There were no significant differences in body composition, fat distribution, insulin sensitivity, or acute insulin response, but DI was significantly lower in IGT children by 16% (P < 0.02), and DI was inversely related to age. In conclusion, IGT is present in 28% of overweight Latino children with a family history of type 2 diabetes, is not influenced by obesity, is more prevalent in children exposed to gestational diabetes mellitus, and is related to poor beta-cell function, which shows signs of deterioration with age in this population.
Goran
Michael I
MI
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA. goran@usc.edu
Bergman
Richard N
RN
Avila
Quintilia
Q
Watkins
Michael
M
Ball
Geoff D C
GD
Shaibi
Gabriel Q
GQ
Weigensberg
Marc J
MJ
Cruz
Martha L
ML
D015502:Absorptiometry, Photon; D000375:Aging; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D001824:Body Constitution; D015992:Body Mass Index; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D016640:Diabetes, Gestational / Q000150:complications; D005190:Family; D005215:Fasting; D005260:Female; D018149:Glucose Intolerance / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D005951:Glucose Tolerance Test; D006630:Hispanic or Latino; D006801:Humans; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000503:physiopathology*; D008297:Male; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D011247:Pregnancy; D011627:Puberty; D012044:Regression Analysis
D001786:Blood Glucose; D007328:Insulin