title: Primary cardiac T-cell lymphoma.
abstract: Primary cardiac lymphoma (PCL), defined as a lymphoma clinically mimicking cardiac disease, with the bulk of the tumor located intrapericardially, is extremely rare in immunocompetent patients. Clinical manifestations vary depending on sites of involvement in the heart and include chest pain, arrhythmias, pericardial effusion, and heart failure. Diagnosis is often difficult and may require invasive procedures; in some cases, diagnosis is not made until autopsy. Histologically, nearly all cases of PCL reported thus far have been of B-cell origin. In this report, we describe a case of PCL of T-cell origin in an adult immunocompetent patient, the second reported in the literature to the best of our knowledge, and provide a brief overview of the features of previously published PCL cases.
authors.affiliation: Division of Internal Medicine, Allergy and Clinical Immunology, Department of Gerontology, Geriatrics and Metabolic Diseases, Second University of Naples School of Medicine, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Giunta
authors.forename: Ranieri G
authors.initials: RG
authors.lastname: Cravero
authors.forename: Gianluca
authors.initials: G
authors.lastname: Granata
authors.forename: Ausilia
authors.initials: A
authors.lastname: Sellitto
authors.forename: Ciro
authors.initials: C
authors.lastname: Romano
authors.forename: Umberto
authors.initials: U
authors.lastname: De Fanis
authors.forename: Giampiero
authors.initials: G
authors.lastname: Foccillo
authors.forename: Cleofina
authors.initials: C
authors.lastname: De Capite
authors.forename: Mario
authors.initials: M
authors.lastname: Santini
authors.forename: Luigi
authors.initials: L
authors.lastname: Rossiello
authors.forename: Raffaele
authors.initials: R
authors.lastname: Rossiello
authors.forename: Giacomo
authors.initials: G
authors.lastname: Lucivero
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood; D001706:Biopsy; D001761:Bleomycin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D003951:Diagnostic Errors; D004317:Doxorubicin / Q000008:administration & dosage; D004417:Dyspnea / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006338:Heart Neoplasms / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D016130:Immunophenotyping; D007770:L-Lactate Dehydrogenase / Q000097:blood; D002955:Leucovorin / Q000008:administration & dosage; D016399:Lymphoma, T-Cell / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood; D014411:Neoplastic Stem Cells / Q000737:chemistry / Q000473:pathology; D010493:Pericarditis / Q000175:diagnosis; D011241:Prednisone / Q000008:administration & dosage; D013601:T-Lymphocytes / Q000737:chemistry / Q000473:pathology; D013610:Tachycardia / Q000209:etiology; D020775:Thoracic Surgery, Video-Assisted; D014750:Vincristine / Q000008:administration & dosage; D014777:Virus Diseases / Q000175:diagnosis
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D001761:Bleomycin; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D007770:L-Lactate Dehydrogenase; D002955:Leucovorin; D011241:Prednisone; D008727:Methotrexate