Successful unrelated cord blood transplantation in an infant with Wiskott-Aldrich syndrome following recurrent cytomegalovirus disease.
We describe successful unrelated cord blood transplantation in a 14-month-old boy with Wiskott-Aldrich syndrome. He had been suffering from recurrent cytomegalovirus (CMV) pneumonia. Ganciclovir was given pretransplantation and posttransplantation, and CMV antigenemia was monitored as a marker of reactivation. The conditioning regimen was cyclophosphamide, busulfan, and antithymocyte globulin. The patient received an HLA 1-locus-mismatched cord blood unit, and the total number of infused nucleated cells was 9.0 x 10(7)/kg. Neutrophil engraftment was achieved on day +20, and a platelet count greater than 50 x 10(9)/L was achieved on day +51. A normal lymphoproliferative response to phytohemagglutinin mitogen was detectable 7 months posttransplantation. Long-term use of ganciclovir prevented CMV reactivation and did not compromise engraftment.
Kaneko
Michiya
M
Department of Pediatrics, University of Tokushima School of Medicine, Tokushima, Japan.
Watanabe
Tsutomu
T
Watanabe
Hiroyoshi
H
Kimura
Masahiro
M
Suzuya
Hiroko
H
Okamoto
Yasuhiro
Y
Nakagawa
Ryuji
R
Kuroda
Yasuhiro
Y
D000998:Antiviral Agents / Q000627:therapeutic use; D036101:Cord Blood Stem Cell Transplantation; D003586:Cytomegalovirus Infections / Q000150:complications / Q000188:drug therapy; D004760:Enterocolitis / Q000150:complications; D015774:Ganciclovir / Q000627:therapeutic use; D006648:Histocompatibility; D006801:Humans; D007223:Infant; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000150:complications; D014019:Tissue Donors; D014184:Transplantation, Homologous; D014923:Wiskott-Aldrich Syndrome / Q000150:complications / Q000628:therapy*
D000998:Antiviral Agents; D015774:Ganciclovir