Efficient synthesis of akolactone A via Pd-catalyzed carbonylation.
The first synthesis of (+)- and (-)-akolactone A is described by using Pd-catalyzed carbonylation. A comparison of the optical rotation of both enantiomers of akolactone A and the natural compound suggests that the absolute configuration at the 4-position of akolactone A is R.
Makabe
Hidefumi
H
Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University, Kamiina, Nagano, Japan. makabeh@gipmc.shinshu-u.ac.jp
Okajima
Motonori
M
Konno
Hiroyuki
H
Kamo
Tsunashi
T
Hirota
Mitsuru
M
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013237:Stereoisomerism
D000970:Antineoplastic Agents; C492583:akolactone A; D015107:4-Butyrolactone