SENV infection in HIV-positive patients: prevalence, subtype characterization, and impact on HIV disease progression.
Among 165 HIV-infected patients, prevalence of SEN virus (SENV) infection was 51.5%, with subtype A predominance and unique SENV variant (67%), but also SENV superinfections with multiple variants were frequent. High prevalence, superinfection and broad SENV subtype diversification have been demonstrated, all linked to intravenous drug use (IVDU) as a risk factor for HIV acquisition. At multivariate analysis, SENV infection did not appear to have any negative impact on survival, while a possible protective effect needs further investigation.
Quiros-Roldan
Eugenia
E
Department of Infectious and Tropical Diseases, Spedali Civili of Brescia, 25123, Italy. kaeniaquiros@hotmail.com
Torti
Carlo
C
Imberti
Luisa
L
Casari
Salvatore
S
Soriano
Vicente
V
Moretti
Francesca
F
Pirovano
Silvia
S
Carosi
Giampiero
G
D000328:Adult; D004267:DNA Viruses / Q000145:classification / Q000235:genetics*; D018450:Disease Progression; D015658:HIV Infections / Q000150:complications* / Q000473:pathology; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000453:epidemiology / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D015819:Substance Abuse, Intravenous / Q000150:complications*