Enzymatic synthesis and antioxidant property of gelatin-catechin conjugates.
Gelatin-catechin conjugate was synthesized by the laccase-catalyzed oxidation of catechin in the presence of gelatin. The conjugate had a good scavenging activity against superoxide anion radicals. Moreover, the conjugate showed an amplified inhibition effect on human low density lipoprotein oxidation initiated by 2,2'-azobis(2-amidinopropane)dihydrochloride as a radical generator.
Chung
Joo Eun
JE
Bio-oriented Technology Research Advancement Institute, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
Kurisawa
Motoichi
M
Uyama
Hiroshi
H
Kobayashi
Shiro
S
D032701:Biomimetics / Q000379:methods; D002392:Catechin / Q000138:chemical synthesis / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry; D005780:Gelatin / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D042845:Laccase / Q000737:chemistry*; D008077:Lipoproteins, LDL / Q000737:chemistry*; D046911:Macromolecular Substances; D010084:Oxidation-Reduction; D011485:Protein Binding; D015202:Protein Engineering / Q000379:methods*; D013481:Superoxides / Q000737:chemistry*
D016166:Free Radical Scavengers; D008077:Lipoproteins, LDL; D046911:Macromolecular Substances; D013481:Superoxides; D002392:Catechin; D005780:Gelatin; D042845:Laccase