Milbemycin alpha17 and related compounds synthesized from milbemycin A4: synthetic procedure and acaricidal activities.
Milbemycin alpha17, a 14-demethyl congener of milbemycin A4, has been reported as a natural product. In this paper, we report the successful development of a chemical derivation method to synthesize milbemycin alpha17 from milbemycin A4, as well as our use of a similar method to prepare 24-demethylmilbemycin A4 from the same precursor. The acaricidal activities of these compounds were assessed against the organophosphorus-sensitive two-spotted spider mites (Tetranychus urticae) on the primary leaves of cowpea plants (Vigna sinesis Savi species) by spraying.
Tsukiyama
Takahiro
T
Agroscience Research Laboratories, Sankyo Agro Co., Ltd. 894 Yasu, Yasu-cho, Yasu-gun, Shiga 520-2342, Japan. tukiya@sankyo-agro.co.jp
Kinoshita
Ayako
A
Ichinose
Reiji
R
Sato
Kazuo
K
D000871:Anthelmintics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D040102:Tetranychidae / Q000187:drug effects*
D000871:Anthelmintics; D018942:Macrolides; C027837:moxidectin