title: Palladium-catalyzed carbonylation of haloindoles: no need for protecting groups.
abstract: [reaction: see text] For the first time, palladium-catalyzed carbonylations of unprotected bromoindoles have been performed successfully with different N- and O-nucleophiles. Various indole carboxylic acid derivatives are accessible in excellent yield. For example, aminocarbonylation of 4-, 5-, 6-, or 7-bromoindole with arylethylpiperazines provides a direct one-step synthesis for CNS active amphetamine derivatives.
authors.affiliation: Leibniz-Institut für Organische Katalyse an der Universität Rostock e.V. (IfOK), Buchbinderstrasse 5-6, D-18055 Rostock, Germany.
authors.forename: Kamal
authors.initials: K
authors.lastname: Kumar
authors.forename: Alexander
authors.initials: A
authors.lastname: Zapf
authors.forename: Dirk
authors.initials: D
authors.lastname: Michalik
authors.forename: Annegret
authors.initials: A
authors.lastname: Tillack
authors.forename: Timo
authors.initials: T
authors.lastname: Heinrich
authors.forename: Henning
authors.initials: H
authors.lastname: Böttcher
authors.forename: Michael
authors.initials: M
authors.lastname: Arlt
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller