Perp-etrating p53-dependent apoptosis.
The induction of apoptosis is a fundamental mechanism by which the p53 transcriptional activator protein suppresses tumor development. Recently, the roles of several p53 target genes in mediating the p53 apoptotic response have been queried through loss-of-function analysis with knockout mouse models. These studies have demonstrated that the p53 targets Noxa, Puma, and Perp play cell type-specific roles in p53-mediated apoptosis. Perp, a tetraspan protein localizing to the plasma membrane, rather than to mitochondria, is a novel type of p53 effector that may stimulate apoptosis through a different mechanism from the BH3-containing proteins Noxa, Puma, and Bax.
Ihrie
Rebecca A
RA
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305-5152, USA.
Attardi
Laura D
LD
D000818:Animals; D017209:Apoptosis; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D008565:Membrane Proteins; D016159:Tumor Suppressor Protein p53