Classical juvenile pityriasis rubra pilaris in a patient with Down syndrome.
We report a case of classical juvenile pityriasis rubra pilaris (CJPRP) in a 15-year-old boy with Down syndrome. The rash was extensive, severe, accompanied by intense itching and responded to low-dose etretinate. Xerosis and cheilitis were also present, suggesting that keratinization defects associated with Down syndrome may be involved in the pathogenesis of CJPRP. PRP is a rare dermatological disorder and to the best of our knowledge, this is the first reported case of CJPRP in a patient with Down syndrome.
Terasaki
K
K
Department of Dermatology, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan. ken0913@m2.kufm.kagoshima-u.ac.jp
Kanekura
T
T
Saruwatari
H
H
Kanzaki
T
T
D000293:Adolescent; D004314:Down Syndrome / Q000150:complications*; D006801:Humans; D008297:Male; D010916:Pityriasis Rubra Pilaris / Q000150:complications* / Q000473:pathology