title: [Future perspectives. From basic research to the development of new therapies aimed at the inhibition of the different stages of signal transduction: applications in breast cancer].
abstract: The mechanism implicated in the carcinogenesis are better understood and the transduction of signal is a potential target for new agents. In this review, we describe the different pathways implicated in the transduction of signal and the potential target for new agents in breast cancer.
authors.affiliation: CRLCC, Centre René-Gauducheau, bd Jacques-Monod, 44805 Saint-Herblain/Nantes. m-campone@nantes.fnclcc.fr
authors.forename: Mario
authors.initials: M
authors.lastname: Campone
authors.forename: Pierre
authors.initials: P
authors.lastname: Kerbrat
authors.forename: Henri
authors.initials: H
authors.lastname: Roché
authors.forename: Jaffar
authors.initials: J
authors.lastname: Bennouna
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Cuillière
authors.forename: Bernard
authors.initials: B
authors.lastname: Le Mevel
authors.forename: Pierre
authors.initials: P
authors.lastname: Fumoleau
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D035843:Biomedical Research; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000502:physiology; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000502:physiology; D015290:Second Messenger Systems; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D017346:Protein Serine-Threonine Kinases; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; D018719:Erb-b2 Receptor Tyrosine Kinases