title: Stereoselective diversity-oriented solution and solid-phase synthesis of tetrahydroquinoline-based polycyclic derivatives.
abstract: A diversity-oriented solution and solid-phase synthesis of tetrahydroquinoline-based tricyclic derivatives has been achieved from enantiomerically pure, natural product-like bicyclic scaffold. The solution synthesis of enantiopure bicyclic scaffold was developed by asymmetric hetero Michael reaction. Our approach for the synthesis of polycyclic derivatives utilized regio- and stereoselective hetero Michael reaction and ring-closing metathesis as key steps in solution and on solid phase.
authors.affiliation: Chemical Biology Program, Steacie Institute for Molecular Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada, K1A 0R6. Prabhat.Arya@nrc.ca
authors.forename: Prabhat
authors.initials: P
authors.lastname: Arya
authors.forename: Patricia
authors.initials: P
authors.lastname: Durieux
authors.forename: Zai-Xin
authors.initials: ZX
authors.lastname: Chen
authors.forename: Reni
authors.initials: R
authors.lastname: Joseph
authors.forename: Donald M
authors.initials: DM
authors.lastname: Leek
mesh_terms: D001894:Borohydrides; D007202:Indicators and Reagents; D018020:Lithium Compounds; D009682:Magnetic Resonance Spectroscopy; D011083:Polycyclic Compounds / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*; D012996:Solutions; D021241:Spectrometry, Mass, Electrospray Ionization; D013237:Stereoisomerism
chemical_list: D001894:Borohydrides; D007202:Indicators and Reagents; D018020:Lithium Compounds; D011083:Polycyclic Compounds; D011804:Quinolines; D012996:Solutions; C040936:lithium borohydride