title: T-cell activation.
abstract: Activation of T lymphocytes results in immediate intracellular biochemical changes, including increases in cytosolic Ca(2+) levels, stimulation of protein kinase C (PKC) and regulation of protein tyrosine kinases (PTKs). This review describes recent advances in the study of the signalling steps downstream of PKC and PTKs in T cells. A model is presented in which the GTP-binding protein p21(ras) acts as an integrator of the signal transduction pathways controlled by the T-cell antigen receptor.
authors.affiliation: The authors are at the Lymphocyte Activation Laboratory, ICRF Laboratories, PO Box 123, Lincoln's, Inn Fields, London, UK WC2A 3PX.
authors.forename: M
authors.initials: M
authors.lastname: Izquierdo
authors.forename: D A
authors.initials: DA
authors.lastname: Cantrell