Immunohistochemical mucin expression of short-segment Barrett's esophagus.
Barrett's mucosa consists of metaplastic columnar epithelium (specialized columnar epithelium) of the esophagus. Recently, "short-segment Barrett's esophagus (SSBE)" was proposed. In the present study, we examined immunohistochemical mucin expression and the Ki-67 labeling index (LI) of SSBE, in 5-15 mm lengths. All 27 SSBE cases showed gastric mucin (MUC5AC, HGM, MUC6). CD10 and MUC2, which were markers of intestinal phenotypes, were detected in 13 (48.1%) and 14 (51.9%) of the 27 SSBE cases. Ki-67 LI of SSBE positive cases for CD10 was 23.6 %, while that of SSBE negative cases for CD10 was 14.4 % (p < 0.05). SSBE cases were divided into two groups: one was gastric epithelium type with low Ki-67 LI, and the other was metaplastic epithelium with intestinal metaplasia and high Ki-67 LI. The latter group was suggested to be more important as a premalignant lesion of esophageal adenocarcinoma.
Yamamoto
Soichiro
S
Department of Surgery, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Kijima
Hiroshi
H
Hara
Tadashi
T
Kenmochi
Takahiro
T
Kise
Yoshifumi
Y
Tanaka
Hikaru
H
Chino
Osamu
O
Shimada
Hideo
H
Tanaka
Makiko
M
Inokuchi
Sadaki
S
Makuuchi
Hiroyasu
H
D001471:Barrett Esophagus / Q000378:metabolism* / Q000473:pathology; D005753:Gastric Mucosa / Q000737:chemistry; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007413:Intestinal Mucosa / Q000737:chemistry / Q000473:pathology; D019394:Ki-67 Antigen / Q000032:analysis; D008679:Metaplasia; D055262:Mucin-2; D009077:Mucins / Q000032:analysis*; D015260:Neprilysin / Q000032:analysis; D013194:Staining and Labeling
D019394:Ki-67 Antigen; C524625:MUC2 protein, human; D055262:Mucin-2; D009077:Mucins; D015260:Neprilysin