title: Gastrin-releasing peptide receptor (GRPR) locus in Japanese subjects with autism.
abstract: Gastrin-releasing peptide receptor (GRPR) gene is considered a candidate locus for infantile autism for several reasons. The present study investigated two polymorphic sites (C/450/T and C/661/T) in the second exon of the GRPR gene in Japanese patients with autism (DSM-IV) and healthy subjects. The two polymorphic sites were at high linkage disequilirium, consistent with a previous study in a North American population. The C450-C661 allele, which was observed in one-third of the chromosomes from the North American subjects, was less frequent (6-7%) in the Japanese subjects, suggesting a large ethnic difference in the frequency of the polymorphism. The allele frequencies and genotype distributions were not significantly different between the patients and controls. However, further studies are required to exclude the GRPR locus as a candidate locus for autism, considering the low frequency of the polymorphism in the Japanese subjects.
authors.affiliation: Department of Psychiatry, Graduate School of Medicine, University of Tokyo, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Marui
authors.forename: Ohiko
authors.initials: O
authors.lastname: Hashimoto
authors.forename: Eiji
authors.initials: E
authors.lastname: Nanba
authors.forename: Chieko
authors.initials: C
authors.lastname: Kato
authors.forename: Mamoru
authors.initials: M
authors.lastname: Tochigi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Umekage
authors.forename: Nobumasa
authors.initials: N
authors.lastname: Kato
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000293:Adolescent; D000328:Adult; D001321:Autistic Disorder / Q000235:genetics*; D002648:Child; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018004:Receptors, Bombesin / Q000235:genetics*
chemical_list: D018004:Receptors, Bombesin