title: [Study on tumor necrosis factor-alpha and interleukin 2 in rat skin allograft].
abstract: OBJECTIVE
  To elucidate the histocompatibility of tissue engineered rat skin through studying the effect of TNF-alpha and IL-2 in immunological rejection after rat skin allograft.
  
  
  METHODS
  Tissue engineered skin that the basic materials were taken from neonatal SD rats was cultured in lab, grafted to adult Wistar rats. The expressions of TNF-alpha and IL-2 in grafted tissue were detected with immunohistochemical staining and Western blot.
  
  
  RESULTS
  The expressions of TNF-alpha and IL-2 were remarkable in skin allograft group, but low in tissue engineered skin group.
  
  
  CONCLUSIONS
  The expressions of TNF-alpha and IL-2 and the immunological rejection were closely related after skin allograft, but the tissue engineered skin has favorable histocompatibility and doesn't arose obvious immunological rejections.
authors.affiliation: Department of Oral Histology and Pathology, College of Stomatology, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Junlin
authors.initials: J
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Jin
authors.forename: Xiaoliang
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D006084:Graft Rejection / Q000276:immunology; D007376:Interleukin-2 / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D012867:Skin / Q000166:cytology* / Q000276:immunology; D016038:Skin Transplantation; D023822:Tissue Engineering; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
chemical_list: D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha