Squaric acids: a new motif for designing inhibitors of protein tyrosine phosphatases.
[structure: see text] Protein tyrosine phosphatases (PTPases) are important targets in medicinal chemistry. These enzymes play a role in a number of human diseases, including type II diabetes and infection by Yersinia pestis, the causative agent of bubonic plague. Derivatives of squaric acids such as 2-aryl-1-hydroxycyclobut-1-ene-3,4-diones represent a new class of monoanionic inhibitors for PTPases.
Xie
Jian
J
Department of Chemistry, Brown University, 324 Brook Street, Providence, Rhode Island 02912, USA.
Comeau
Anthony B
AB
Seto
Christopher T
CT
D000577:Amides / Q000737:chemistry / Q000494:pharmacology; D003503:Cyclobutanes / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008956:Models, Chemical; D015394:Molecular Structure; D017027:Protein Tyrosine Phosphatases / Q000037:antagonists & inhibitors* / Q000737:chemistry
D000577:Amides; D003503:Cyclobutanes; D004791:Enzyme Inhibitors; D017027:Protein Tyrosine Phosphatases; C030042:squaric acid