title: Heat-shock proteins maintain the viability of ATP-deprived cells: what is the mechanism?
abstract: ATP depletion causes necrosis in mammalian cells. However, a previous heat shock can protect cells from the effects of energy deprivation, probably as a result of the synthesis and accumulation of heat-shock proteins (hsps). We propose that hsps protect ATP-depleted cells from rapid necrotic death by inhibiting the aggregation of cytoskeletal proteins that occurs when ATP synthesis is blocked.
authors.affiliation: Department of Radiation Biochemistry, Medical Radiology Research Center, 4 Korolev St, Obninsk 249020, Russia.
authors.forename: A E
authors.initials: AE
authors.lastname: Kabakov
authors.forename: V L
authors.initials: VL
authors.lastname: Gabai