title: Transporter's evolution and carbohydrate metabolic clusters.
abstract: The yiaQRS genes of Escherichia coli K-12 are involved in carbohydrate metabolism. Clustering of homologous genes was found throughout several unrelated bacteria. Strikingly, all four bacterial transport protein classes were found, conserving transport function but not mechanism. It appears that during evolution the ability to transport, phosphorylate and metabolize substrates of unknown identity have been conserved. However, the transporter classes have been swapped. This probably demonstrates the subtlety of transport-protein evolution.
authors.affiliation: Department of Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, P.O. Box 14, 9750 AA Haren, The Netherlands.
authors.forename: Titia H
authors.initials: TH
authors.lastname: Plantinga
authors.forename: Chris
authors.initials: C
authors.lastname: van der Does
authors.forename: Arnold J M
authors.initials: AJ
authors.lastname: Driessen
mesh_terms: D001419:Bacteria / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D001692:Biological Transport; D050260:Carbohydrate Metabolism; D019143:Evolution, Molecular; D026901:Membrane Transport Proteins / Q000235:genetics* / Q000378:metabolism; D005810:Multigene Family
chemical_list: D001426:Bacterial Proteins; D026901:Membrane Transport Proteins