title: Microtubule-severing activity in M phase.
abstract: The stable cytoplasmic microtubules that emanate from centrosomes in eukaryotic cells disappear at the onset of M phase and are replaced by the dynamic microtubules of the mitotic spindle. Microtubule-severing activity increases significantly under the control of maturation-promoting factor at the transition between G2 phase and M phase, and is thought to be involved in the microtubule reorganization. This review highlights three microtubule-severing factors that may be responsible for microtubule-severing activity in M phase.
authors.affiliation: Dept of Genetics and Molecular Biology, Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606-01, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Shiina
authors.forename: Y
authors.initials: Y
authors.lastname: Gotoh
authors.forename: E
authors.initials: E
authors.lastname: Nishida