title: [Success rate in patients with lung TB registered in Braşov county between 1990 and 2001].
abstract: The purpose of the present study was to assess the success rate of TB pulmonary cases registered in the district of Braşov between 1 january 1990-31 December 2001 and followed from 0 to 154 months. The retrospective study for 1990-1994 and prospective for 1995-2001 included 4369 pulmonary cases over 14 years in age, respectively 3912 new and 587 relapsed cases. To these patients were analysed the favorable and unfavorable evolutions, including relapses cases. The evaluation of the first treatment after National TB Program's 2001-2005 standards showed 2893 favorable evolutions, respectively 1612 (42.4%) cured and 1281 (33.7%) completed treatment and unfavorable evolutions 795 cases: 284 failures (7.5%), 345 defaulters (9%) and 166 TB deaths (4.4%). To these were associated 224 (5.9%) relapses cases appeared after 12 months from the begining of the treatment. Between relapses cases were analysed as favorable evolutions 332 cases respectively 207 (36.6%) cured and 125 (22.1%) completed treatment and unfavorable evolutions 217 cases: 68 failures (12%), 118 defaulters (20.9%) and 31 TB deaths (5.5%). To these were associated 38 (6.7%) relapses cases appeared after 12 months from begining of the treatment. An age group of new cases with the highest percentage of the favorable evolutions, respectively 89% (p < 0.001) at women was 15-24 years and for the unfavorable evolutions, respectively 33% at men was 35-44 (p < 0.05) and over 65 years. The comparison on the bacteriological categories between new and relapses cases showed that the percentage of the favorable evolutions was significantly higher at new-cases. At new cases after 12 years of supervision, the rate of success varied a little and registered the less value of 77% at 9 years of monitoring, and finally a level of 78.5%. At relapses cases, after a diminution in the first 3 years until 59.2%, the value bring up year after year and registered a peak of 72.4% at 8 years of monitoring. After 12 years, the rate of success of the first retreatment was 58.8% representing the less level of the whole interval. For the new cases at the first treatment the risk of failure was 8.6%, default 10.3% and tb death 5% and for the relapses cases at the first retreatment the risk of failure was 15.8%, default 25.2% and TB death 7.2%. The risk of relapse for new cases varied between 2.9% at 2 years and 1% at 10 years, and for the relapses cases between 6.1% at 2 years and 1% after 8 years of monitoring. The preoccupation for augmentation the level of the success of the first treatment might improve the performances on the long time in tuberculosis control.
authors.affiliation: Spitalul de Pneumoftiziologie, Braşov.
authors.forename: C
authors.initials: C
authors.lastname: Macavei
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003196:Computer Graphics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012008:Recurrence; D012189:Retrospective Studies; D012383:Romania / Q000453:epidemiology; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology / Q000628:therapy*