title: Elevated seroprevalence of human herpesvirus 8 among men with prostate cancer.
abstract: Background. To investigate any epidemiological association between human herpesvirus (HHV)-8 and prostate cancer, we determined the prevalence of HHV-8 seropositivity among prostate cancer case and control subjects in the United States and Trinidad and Tobago.Methods. Antibodies against HHV-8 were detected in 2 independent laboratories using either indirect immunofluorescence assay (IFA) or a combination of enzyme-linked immunosorbent assay and IFA.Results. Among 138 Tobago men with prostate cancer, HHV-8 seroprevalence was 39.9%-significantly higher than that among 140 age-matched control subjects (22.9%; P=.003; odds ratio [OR], 2.24; 95% confidence interval [CI], 1.29-3.90). Among 100 US men with prostate cancer, seroprevalence was 20%-significantly higher than that of 177 blood donors (5.1%; P=.001; OR, 4.67; 95% CI, 1.91-11.65) and higher than that of 99 men with cancer not related to HHV-8 (13%; P=.253; 95% CI, 0.77-3.54).Conclusions. HHV-8 seropositivity is elevated among men with prostate cancer compared with control subjects, which suggests that HHV-8 plays a role in the development of prostate cancer.
authors.affiliation: Department of Infectious Diseases and Microbiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Hoffman
authors.forename: Clareann H
authors.initials: CH
authors.lastname: Bunker
authors.forename: Philip E
authors.initials: PE
authors.lastname: Pellett
authors.forename: Donald L
authors.initials: DL
authors.lastname: Trump
authors.forename: Alan L
authors.initials: AL
authors.lastname: Patrick
authors.forename: Sheila C
authors.initials: SC
authors.lastname: Dollard
authors.forename: Hillary A
authors.initials: HA
authors.lastname: Keenan
authors.forename: Frank J
authors.initials: FJ
authors.lastname: Jenkins
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000097:blood*; D016022:Case-Control Studies; D015897:Comorbidity; D016001:Confidence Intervals; D006566:Herpesviridae Infections / Q000097:blood / Q000453:epidemiology*; D019288:Herpesvirus 8, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D011471:Prostatic Neoplasms / Q000097:blood / Q000453:epidemiology*; D016036:Seroepidemiologic Studies; D014300:Trinidad and Tobago / Q000453:epidemiology; D014481:United States / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral