Development of a depressed left ventricular ejection fraction in patients with left ventricular hypertrophy and a normal ejection fraction.
The progression from concentric left ventricular (LV) hypertrophy to heart failure has not been well defined. Of 159 predominantly hypertensive African-American patients with LV hypertrophy and a normal ejection fraction (EF), 28 (18%) developed a reduced EF after a median follow-up of approximately 4 years. Risk factors for this outcome included a history of coronary artery disease, pulmonary edema seen on a chest x-ray, or a subsequent myocardial infarction.
Rame
J Eduardo
JE
Cardiovascular Branch, National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.
Ramilo
Marlon
M
Spencer
Nali
N
Blewett
Christopher
C
Mehta
Sameer K
SK
Dries
Daniel L
DL
Drazner
Mark H
MH
D001741:Black or African American; D003327:Coronary Disease / Q000453:epidemiology; D018450:Disease Progression; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology; D011654:Pulmonary Edema / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D013318:Stroke Volume / Q000502:physiology*; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*