title: Strong protective action of Copper(II) N-substituted sulfonamide complexes against reactive oxygen species.
abstract: Copper(II) complexes of N-benzothiazolsulfonamides, [Cu(N-2-(5,6-dimethylbenzothiazole)toluenesulfonamidate)(2)(dmso)(2)] (1), [Cu(N-2-(6-chlorobenzothiazole)benzenesulfonamidate)(2)(dmso)(2)] (2) and [Cu(N-2-(6-chlorobenzothiazole)toluenesulfonamidate)(2)(dmso)(2)] (3) with interesting protective properties against superoxide radicals have been prepared. The compounds have been characterized by X-ray diffraction and their chemical properties have been studied by spectroscopic methods. The crystal structure of 1 shows that the copper(II) is surrounded by two benzothiazole N atoms from the sulfonamide ligands and two O atoms from the dimethylsulfoxide molecules in a square planar arrangement. The coordination polyhedron around copper(II) in 2 and 3 is distorted square pyramidal being the metal ion linked to benzothiazole N and sulfonamidate O atoms of the ligand and to two dimethylsulfoxide O atoms. The three complexes have a strong protective action over Delta sod1 mutant of Saccharomyces cerevisiae against reactive oxygen radicals derived from respiration and against those generated by hydrogen peroxide and menadione.
authors.affiliation: Departamento de Química Inorgánica, Facultad de Farmacia, Universidad de Valencia, Avda. Vicent Andrés Estellés s/n, 46100 Burjassot, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: González-Alvarez
authors.forename: Gloria
authors.initials: G
authors.lastname: Alzuet
authors.forename: Joaquín
authors.initials: J
authors.lastname: Borrás
authors.forename: Lucas
authors.initials: L
authors.lastname: del Castillo Agudo
authors.forename: Santiago
authors.initials: S
authors.lastname: García-Granda
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Montejo Bernardo