title: Magnesiation employing Grignard reagents and catalytic amine. Application to the functionalization of N-phenylsulfonylpyrrole.
abstract: [reaction: see text] N-Phenylsulfonylpyrrole 1 is magnesiated by treatment with isopropylmagnesium chloride and catalytic diisopropylamine. Reaction with various electrophiles, including palladium-catalyzed aryl- and heteroaryl cross-coupling, provides 2-substituted phenylsulfonylpyrroles in moderate to good yields.
authors.affiliation: Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO Wits, 2050, South Africa. andy@aurum.wits.ac.za
authors.forename: Andrew
authors.initials: A
authors.lastname: Dinsmore
authors.forename: David G
authors.initials: DG
authors.lastname: Billing
authors.forename: Karen
authors.initials: K
authors.lastname: Mandy
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Michael
authors.forename: Daniel
authors.initials: D
authors.lastname: Mogano
authors.forename: Shivaputra
authors.initials: S
authors.lastname: Patil