APC activators caught by their tails?
The complexity of the Anaphase-Promoting Complex (APC), the major ubiquitin ligase in mitotic control, has been puzzling investigators ever since its discovery. Recent biochemical and genetic studies have now provided insights not only into the architecture of the complex, but also into how activators are recruited to the APC. In this article, we discuss the implications of these findings on our current understanding of APC activation.
Vodermaier
Hartmut C
HC
Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, Vienna, Austria. vodermaier@imp.univie.ac.at
Peters
Jan-Michael
JM
D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D006801:Humans; D043743:Ubiquitin-Protein Ligase Complexes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome