The Fas/APO-1 receptor and its deadly ligand.
The cell surface receptor Fas/APO-1 and its ligand have recently been identified as important mediators of apoptosis. Both molecules are crucial for the maintenance of a sound immune system, and when defective they give rise to severe autoimmune disorders. Understanding the mechanism and regulation of Fas/APO-1-triggered cell death promises important insights for the pathogenesis of AIDS, cancer and autoimmune diseases.
Schulze-Osthoff
K
K
Institute for Biochemistry, Albert-Ludwigs-University, Hermann-Herder-Str. 7, D-79104 Freiburg, Germany.