A novel naphthanol glycoside from Terminalia arjuna with antioxidant and nitric oxide inhibitory activities.
A novel naphthanol glycoside, arjunaphthanoloside (1), was isolated from the stem bark of Terminalia arjuna and its structure was established as 2,3,6,7,8,9-hexahydroxynaphthalene-2-O-alpha-L(-)-rhamnoside by means of spectroscopic and chemical methods. Compound 1 showed potent antioxidant activity and inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated rat peritoneal macrophages.
Ali
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A
Faculty of Pharmacy, Hamdard University, Hamdard Nagar, New Delhi, India.
Kaur
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G
Hayat
K
K
Ali
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Ather
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M
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001713:Biphenyl Compounds; D002316:Cardiotonic Agents / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology*; D006868:Hydrolysis; D066298:In Vitro Techniques; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000737:chemistry; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D009281:Naphthalenes / Q000737:chemistry / Q000494:pharmacology*; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II; D010851:Picrates / Q000378:metabolism; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013481:Superoxides / Q000378:metabolism; D029766:Terminalia / Q000737:chemistry*
D000975:Antioxidants; D001713:Biphenyl Compounds; D002316:Cardiotonic Agents; D016166:Free Radical Scavengers; D006027:Glycosides; D008070:Lipopolysaccharides; D008077:Lipoproteins, LDL; D009281:Naphthalenes; D010851:Picrates; D010936:Plant Extracts; C480719:arjunaphthanoloside; D013481:Superoxides; D009569:Nitric Oxide; C004931:1,1-diphenyl-2-picrylhydrazyl; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496318:Nos2 protein, rat