Immunization with ACE (Angiotensin Converting Enzyme) develops diabetic changes in the kidney and retina in diabetogenic rats.
In normal New Zealand white rabbits, immunization with rabbit lung ACE (angiotensin converting enzyme) induced atherosclerotic retinal changes, and glomerular changes similar to those seen in diabetic nephropathy. Also, in genetically diabetogenic rats, immunization with the rabbit lung ACE induced diabetic nephropathy and retinopathy.
Nishida
Seikoh
S
Division of Endocrinology, Department of Medicine, Kawasaki Medical School, Okayama, Japan.
Sasaki
Tamaki
T
Kimura
Hisashi
H
Tanaka
Junji
J
Nohno
Tsutomu
T
Hirokawa
Yasushi
Y
Matsuki
Michihiro
M
Ichihara
Kiyoshi
K
D000818:Animals; D000906:Antibodies / Q000032:analysis; D001161:Arteriosclerosis / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000276:immunology / Q000473:pathology; D003928:Diabetic Nephropathies / Q000276:immunology* / Q000473:pathology*; D003930:Diabetic Retinopathy / Q000276:immunology* / Q000473:pathology*; D005260:Female; D007114:Immunization; D007678:Kidney Glomerulus / Q000473:pathology; D008168:Lung / Q000737:chemistry; D007703:Peptidyl-Dipeptidase A / Q000276:immunology* / Q000302:isolation & purification; D011817:Rabbits; D051381:Rats; D020334:Rats, Inbred OLETF; D011919:Rats, Inbred Strains; D012160:Retina / Q000473:pathology
D000906:Antibodies; D007703:Peptidyl-Dipeptidase A