title: [A pilot study of repair of periodontal bone defects with carbonated phosphate bone cement modified with synthesized peptides in dogs].
abstract: OBJECTIVE
  To explore the possibility of repairing periodontal defects with carbonated calcium phosphate bone cement (CCPBC) modified with synthesized peptides.
  
  
  METHODS
  Periodontal bone defects in 4 dogs were surgically created and then restored directly with hydroxyapatite (HA), Perioglass, CCPBC and CCPBC modified with peptides. The results were compared at different levels.
  
  
  RESULTS
  Bone replacement materials were lost in HA and Perioglass groups. In the HA group defects were restored with connective tissue. Perioglass group had only a little new bone around materials by alveolar bone. CCPBC could firmly stay in bone defects to maintain the space of bone defects even without membrane use. CCPBC modified with peptides was superior to HA, Perioglass, and CCPBC, surrounded by a great deal of new bone.
  
  
  CONCLUSIONS
  Under limitation of this study, CCPBC modified with peptides has some osteoinuctive activity and may have good prospect for the clinical application in periodontal defect repair.
authors.affiliation: Department of Stomatology, PLA General Hospital, Beijing 100853, China.
authors.forename: Jiang-hai
authors.initials: JH
authors.lastname: Ning
authors.forename: Hong-chen
authors.initials: HC
authors.lastname: Liu
authors.forename: Ke-ya
authors.initials: KY
authors.lastname: Mao
authors.forename: He-ping
authors.initials: HP
authors.lastname: Pan
authors.forename: Hui-xin
authors.initials: HX
authors.lastname: Wang
mesh_terms: D016301:Alveolar Bone Loss / Q000628:therapy*; D000818:Animals; D001843:Bone Cements; D001861:Bone Regeneration; D018786:Bone Substitutes; D002130:Calcium Phosphates; D004285:Dogs; D017886:Durapatite; D008297:Male
chemical_list: D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; D017886:Durapatite; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous