Widespread vertebral and epidural venous plexus metastasis of prostatic carcinoma presenting wedge-shaped radial lesions in the spinal cord.
The present case is the first autopsy case of prostatic carcinoma presenting widespread spinal epidural venous plexus tumor cell emboli with wedge-shaped spinal cord lesions. There has been no previous report of prostatic carcinoma showing tumor cell emboli in the spinal and cranial base epidural venous plexus, in spite of the fact that the incidence of vertebral metastasis in prostatic carcinoma is high, and that presence of continuity from pelvic organs to venous plexus around vertebrae, up to foramen magnum, has been reported. The present case shows that the possibility of spinal cord injury, not by direct compression, but by venous circulatory disturbance as a result of tumor cell emboli to veins, should be taken into consideration on medical treatment of prostatic carcinoma.
Oyanagi
Kiyomitsu
K
Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan. k123ysm@tmin.ac.jp
Ogata
Kentaro
K
Takeda
Shigeki
S
Horikawa
Yo
Y
Kawakami
Emiko
E
Morita
Takashi
T
D000328:Adult; D002277:Carcinoma / Q000503:physiopathology / Q000556:secondary*; D015174:Epidural Neoplasms / Q000503:physiopathology / Q000556:secondary*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000503:physiopathology; D013116:Spinal Cord / Q000098:blood supply / Q000473:pathology; D013131:Spine / Q000473:pathology