Prenatal diagnosis in a haemophilia A family by both factor VIII activity and antigen measurements.
With the advent of molecular biology techniques prenatal diagnosis in haemophilia A is generally being performed by first trimester chorionic villus sampling followed by the DNA analysis using various polymorphic markers of factor VIII gene. Here we report antenatal diagnosis in a haemophilia A family performed in the second trimester by measuring both factor VIII:C and factor VIII:Ag in the fetal blood sample.
Shetty
Shrimati
S
Institute of Immunohematology (ICMR), 13th Floor, KEM Hospital, Parel, Mumbai 400 012, India.
Ghosh
Kanjaksha
K
Mohanty
Dipika
D
D000328:Adult; D005169:Factor VIII / Q000235:genetics*; D005260:Female; D006467:Hemophilia A / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010375:Pedigree; D011247:Pregnancy; D011296:Prenatal Diagnosis
D005169:Factor VIII