title: Specific IgE induced by Kudoa sp. (Myxosporea: Multivalvulida) antigens in BALB/c mice.
abstract: The majority of Kudoa species infect the somatic muscle of fish establishing cysts. As there is no effective method to detect infected fish without destroying them, these parasited fish reach the consumer. We have developed this work to determine whether this parasite contains antigenic compounds capable of provoking an immune response in laboratory animals, in order to consider the possible immunopathological effects in man by the ingestion of Kudoa infected fish. BALB/c mice were injected by the subcutaneous route with the following extracts suspended in aluminium hydroxide: Group 1 (black Kudoa sp. pseudocyst extract), group 2 (white Kudoa sp. pseudocyst extract). Specific IgE levels were measured by ELISA. IgE detected in both groups 1 and 2 showed the possible allergenic nature of some of the components of the parasitic extracts.
authors.affiliation: Department of Parasitology, Faculty of Pharmacy, Complutense University, Pl. Ramón y Cajal s/n., 28040 Madrid, Spain.
authors.forename: G
authors.initials: G
authors.lastname: Martínez de Velasco
authors.forename: M
authors.initials: M
authors.lastname: Rodero
authors.forename: C
authors.initials: C
authors.lastname: Cuéllar
mesh_terms: D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis / Q000097:blood*; D000953:Antigens, Protozoan / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D056890:Eukaryota / Q000276:immunology*; D005393:Fish Diseases / Q000276:immunology / Q000469:parasitology*; D005399:Fishes; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000097:blood*; D051379:Mice; D008807:Mice, Inbred BALB C; D018482:Muscle, Skeletal / Q000469:parasitology; D011529:Protozoan Infections, Animal / Q000276:immunology / Q000469:parasitology*
chemical_list: D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D007073:Immunoglobulin E