title: DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia.
abstract: Two novel mutations recently have been identified in the DJ-1 gene that cause a new form of autosomal recessive, early-onset parkinsonism. Because the pathological role of this protein is unknown, we examined the issue here and report the colocalization of DJ-1 protein within a subset of pathological tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Our study extends the view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ-1.
authors.affiliation: Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Rizzu
authors.forename: David A
authors.initials: DA
authors.lastname: Hinkle
authors.forename: Victoria
authors.initials: V
authors.lastname: Zhukareva
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Bonifati
authors.forename: Lies-Anne
authors.initials: LA
authors.lastname: Severijnen
authors.forename: Daniel
authors.initials: D
authors.lastname: Martinez
authors.forename: Rivka
authors.initials: R
authors.lastname: Ravid
authors.forename: Wouter
authors.initials: W
authors.lastname: Kamphorst
authors.forename: James H
authors.initials: JH
authors.lastname: Eberwine
authors.forename: Virginia M-Y
authors.initials: VM
authors.lastname: Lee
authors.forename: John Q
authors.initials: JQ
authors.lastname: Trojanowski
authors.forename: Peter
authors.initials: P
authors.lastname: Heutink
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D019556:COS Cells; D002522:Chlorocebus aethiops; D003704:Dementia / Q000378:metabolism / Q000473:pathology*; D006367:HeLa Cells; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000378:metabolism* / Q000648:ultrastructure; D047908:Intracellular Signaling Peptides and Proteins; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000378:metabolism / Q000473:pathology; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D020734:Parkinsonian Disorders / Q000378:metabolism / Q000473:pathology*; D000071617:Protein Deglycase DJ-1; D014162:Transfection; D016875:tau Proteins / Q000378:metabolism*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D015513:Oncogene Proteins; D016875:tau Proteins; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1