Toward the total synthesis of natural peloruside a: stereoselective synthesis of the backbone of the core.
[reaction: see text] An asymmetric synthesis of the backbone of the core of natural peloruside A is described. Key elements include reiterative application of enantioselective allylation to establish the stereochemistry of the backbone and a double asymmetric aldol reaction to successfully couple two fragments.
Liu
Bo
B
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. China.
Zhou
Wei-Shan
WS