title: Brain dopamine-stimulated adenylyl cyclase activity in Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy.
abstract: The dopamine D(1) receptor is considered to participate in levodopa's antiparkinsonian action and levodopa-induced dyskinesias. We examined the functional status of the D(1) receptor in brain of patients with Parkinson's disease (PD), multiple system atrophy (MSA), and progressive supranuclear palsy (PSP). Dopamine-stimulated adenylyl cyclase activity was significantly increased in putamen (+43%) and frontal cortex (+52%) in PD, normal in PSP, but decreased by 47% in putamen in MSA. The supersensitive dopamine D(1) receptors in both striatum and cerebral cortex in PD might compensate for dopamine deficiency, but could also contribute to long-term complications of levodopa therapy.
authors.affiliation: Human Neurochemical Pathology Laboratory, Center for Addiction and Mental Health, Toronto, Canada. junchao_tong@camh.net
authors.forename: Junchao
authors.initials: J
authors.lastname: Tong
authors.forename: Paul S
authors.initials: PS
authors.lastname: Fitzmaurice
authors.forename: Lee Cyn
authors.initials: LC
authors.lastname: Ang
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Furukawa
authors.forename: Mark
authors.initials: M
authors.lastname: Guttman
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Kish
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D004298:Dopamine / Q000378:metabolism; D004789:Enzyme Activation / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000503:physiopathology*; D010300:Parkinson Disease / Q000503:physiopathology*; D017447:Receptors, Dopamine D1 / Q000378:metabolism*; D013494:Supranuclear Palsy, Progressive / Q000503:physiopathology*
chemical_list: D017447:Receptors, Dopamine D1; D000262:Adenylyl Cyclases; D004298:Dopamine