Evidence of mnt-myc antagonism revealed by mnt gene deletion.
Myc proteins play a central role in promoting cell proliferation and contribute to a diverse array of cancers. My function appears completely dependent on heterodimerization with Max through related bHLHZip regions. Max interaction with Myc is required for DNA binding at so-called E-box sequences and Myc-dependent transcriptional activation. The repressor with similar DNA binding specificity raised the possibility that Mnt may serve a general role as a Myc antagonist.
Hurlin
Peter J
PJ
Shriners' Hospital for Children, Department of Cell and Developmental Biology, Oregon Health Sciences University, Portland, Oregon USA. pjh@shcc.org
Zhou
Zi-Qiang
ZQ
Toyo-Oka
Kazuhito
K
Ota
Sara
S
Walker
William L
WL
Hirotsune
Shinji
S
Wynshaw-Boris
Anthony
A
D000818:Animals; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D050976:Basic-Leucine Zipper Transcription Factors; D002455:Cell Division / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D017353:Gene Deletion; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D016153:Genes, Suppressor; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D051379:Mice; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors / Q000235:genetics*; D016271:Proto-Oncogene Proteins c-myc / Q000037:antagonists & inhibitors / Q000235:genetics*; D012097:Repressor Proteins; D014157:Transcription Factors; D014158:Transcription, Genetic / Q000235:genetics
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D050976:Basic-Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; C484561:Mnt protein, mouse; C067850:Myc associated factor X; D009687:Nuclear Proteins; D016271:Proto-Oncogene Proteins c-myc; D012097:Repressor Proteins; D014157:Transcription Factors; C068422:Max protein, mouse