Pharmacodynamics and dosing of aminoglycosides.
Aminoglycosides are concentration-dependent killing agents whose pharmacodynamic predictors of efficacy are the area-under-the-curve to minimum inhibitory concentration ratio and the peak to minimum inhibitory concentration ratio. Prospective studies have shown that these agents can be given once-daily or less frequently in most clinical settings, with equal efficacy and possible reduced toxicity. Dosages for different clinical settings have been studied and methods are available to monitor once-daily dosing.
Turnidge
John
J
Division of Laboratory Medicine, Women's and Children's Hospital, 72 King William Road, North Adelaide, SA, 5062, Australia. turnidgej@wch.sa.gov.au
D000328:Adult; D000617:Aminoglycosides / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology; D000818:Animals; D019540:Area Under Curve; D002648:Child; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy*; D006207:Half-Life; D034381:Hearing Loss / Q000139:chemically induced; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced; D008297:Male; D014018:Tissue Distribution
D000617:Aminoglycosides