[Association of polymorphism of genetic markers of CYP19 and CYP17 with sporadic breast cancer].
Polymorphic alleles of CYP17 and CYP19, which are involved in estrogen biosynthesis, were tested for association with breast cancer (BC). Microsatellite (TTTA)n and 3-bp deletion of CYP19 and single-nucleotide polymorphism T27C of CYP17 were analyzed in 123 BC patients and 119 healthy women. Of the six (TTTA)n alleles observed, allele (TTTA)8 proved to be associated with BC (11.8% vs. 6.3%, P = 0.04). Genotype A2/A2 of CYP17 was also associated with BC (32.5% vs. 20.2%, P = 0.04). Risk of BC was especially high in the presence of both factors (7.3% vs. 0%, P < 0.01). Allele (TTTA)8 and genotype A2/A2 were assumed to be risk factors of BC.
Artamonov
V V
VV
Medical Genetic Research Center, Russian Academy of Medical Sciences, Moscow, 115478 Russia.
Liubchenko
L N
LN
Shabanov
M A
MA
Babenko
O V
OV
Nemtsova
M V
MV
Zaletaev
D V
DV
D000483:Alleles; D001141:Aromatase / Q000235:genetics*; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics*; D004591:Electrophoresis, Polyacrylamide Gel; D005819:Genetic Markers; D006801:Humans; D011110:Polymorphism, Genetic; D017384:Sequence Deletion; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics*
D005819:Genetic Markers; D001141:Aromatase; D013254:Steroid 17-alpha-Hydroxylase