title: Anticardiolipin beta2-glycoprotein I antibody: is a high titer related to unfavorable pregnancy outcome?
abstract: We present the clinical characteristics of pregnancy histories and subsequent pregnancy outcomes of 13 women who tested positive for anticardiolipin beta2-glycoprotein I antibody (aCLbeta2GPI). Six of the 13 women had a history of recurrent spontaneous abortion (RSA). The prevalence of aCLbeta2GPI syndrome among women with RSA was very low (2.1%). Other women with aCLbeta2GPI were identified by the presence of a biological false-positive serological test for syphilis, intrauterine growth restriction (IUGR), and a history of thrombosis. However, serum aCLbeta2GPI titers in the 13 women varied, with a wide range from 3.6 to 1468 U/mL. Their pregnancy histories, subsequent pregnancy outcomes, and complications were compared according to the classification of serum aCLbeta2GPI titers as low, moderate, or high. The history of second trimester fetal death was found only in women with high serum aCLbeta2GPI titers. All women with high serum aCLbeta2GPI titers experienced severe maternal-fetal complications such as IUGR, fetal distress, systemic thromboembolism, and neonatal sequelae in subsequent pregnancies.
authors.affiliation: Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. yhideto@med.hokudai.ac.jp
authors.forename: Hideto
authors.initials: H
authors.lastname: Yamada
authors.forename: Emi H
authors.initials: EH
authors.lastname: Kato
authors.forename: Mamoru
authors.initials: M
authors.lastname: Morikawa
authors.forename: Shigeki
authors.initials: S
authors.lastname: Shimada
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Ebina
authors.forename: Noriaki
authors.initials: N
authors.lastname: Sakuragi
authors.forename: Shigenori
authors.initials: S
authors.lastname: Suzuki
authors.forename: Hisanori
authors.initials: H
authors.lastname: Minakami
mesh_terms: D000026:Abortion, Habitual / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002308:Cardiolipins / Q000276:immunology; D005260:Female; D005316:Fetal Distress / Q000453:epidemiology; D005317:Fetal Growth Retardation / Q000453:epidemiology; D006023:Glycoproteins / Q000097:blood* / Q000276:immunology; D006801:Humans; D008487:Medical History Taking; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000453:epidemiology*; D011256:Pregnancy Outcome; D053482:beta 2-Glycoprotein I
chemical_list: D015415:Biomarkers; D002308:Cardiolipins; D006023:Glycoproteins; D053482:beta 2-Glycoprotein I