title: [Pancreatic metastasis from lung cancer: report of an autopsy case].
abstract: A 69 year-old man with abnormal lung shadows in the right lung field was admitted to our hospital. A chest computed tomography (CT) scan showed a lung tumor with hilar and mediastinal lymph node swelling. A CT scan of the abdomen demonstrated a solitary pancreatic head tumor with a diameter of 3 cm. Pathological examination of a transbronchial biopsy specimen revealed squamous cell carcinoma (SCC) of the lung. Since obstructive jaundice had progressed rapidly, the patient received endoscopic nasobiliary drainage (ENBD) and stent-drainage therapy prior to chemotherapy using gemcitabine. However, he died 4 months later of respiratory failure and systemic candidiasis associated with progression of the cancer. An autopsy was performed, and microscopic and immunohistochemical examination revealed that the pancreatic tumor was a metastasis from lung cancer. To our knowledge, obstructive jaundice due to pancreatic metastasis from lung SCC, especially that preceding the advent of a clinical manifestation of primary lung cancer, has rarely been reported.
authors.affiliation: Third Department of Medicine, Kochi Medical School, Kochi 783-8505, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kubota
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ikezoe
authors.forename: Ryoji
authors.initials: R
authors.lastname: Harada
authors.forename: Hideshi
authors.initials: H
authors.lastname: Nakata
authors.forename: Makoto
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Hirokuni
authors.initials: H
authors.lastname: Taguchi
mesh_terms: D000368:Aged; D018288:Carcinoma, Small Cell / Q000150:complications / Q000556:secondary*; D006801:Humans; D041781:Jaundice, Obstructive / Q000209:etiology / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D010190:Pancreatic Neoplasms / Q000150:complications / Q000556:secondary*