title: [Effects of different dosages of cyclosporine A on the semen parameters of renal transplant patients].
abstract: OBJECTIVE
  To evaluate the effects of different dosages of cyclosporine A (CsA) on the main semen parameters and sperm morphology of the patients after renal transplantation.
  
  
  METHODS
  The semen of 18 patients after renal transplantation treated with different dosages of CsA was analyzed and the semen parameters and sperm morphology were compared with those of 12 normal volunteers.
  
  
  RESULTS
  There was not significant difference between the main parameters of the patients treated with 1.5-3.0 mg.Kg-1.d-1 of CsA and 3.1-5.5 mg.Kg-1.d-1 of CsA and those of the volunteers (P > 0.05), but the rate of normal sperm morphology was significantly different between the two groups(P < 0.05).
  
  
  CONCLUSIONS
  Different therapeutic dosages of CsA did not have any effect on most of the semen parameters of the patients after renal transplantation, but did affect the sperm morphology.
authors.affiliation: Renal Transplantation Center, Hospital 117 of PLA, Hangzhou, Zhejiang 310014, China.
authors.forename: Long-Gen
authors.initials: LG
authors.lastname: Xu
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Xu
authors.forename: Jun-Rong
authors.initials: JR
authors.lastname: Zhang
authors.forename: Qi-Zhe
authors.initials: QZ
authors.lastname: Song
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Qi
authors.forename: Xin-Hong
authors.initials: XH
authors.lastname: Wang
mesh_terms: D000328:Adult; D016572:Cyclosporine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D016030:Kidney Transplantation; D008297:Male; D012661:Semen / Q000187:drug effects; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine