title: T-cell large granular lymphocytic leukemia occurring after autologous peripheral blood stem cell transplantation.
abstract: A 61-year-old man with angioimmunoblastic lymphoma in first complete remission underwent autologous peripheral blood stem cell transplantation. At 1 month post transplant, asymptomatic large granular lymphocytosis developed. The surface marker profile of the cells was CD3+CD8+CD56-CD57+. The disease course was chronic and indolent. The patient remains in complete remission from angioimmunoblastic lymphoma more than 6 months post transplant with persistent large granular lymphocytosis (lymphocyte count, 5-15 x 10(9)/l). Although post transplantation T-cell lymphoproliferative disorders have mostly occurred in allogeneic transplantation recipients and presented as aggressive lymphomas/leukemias, we suggest that chronic indolent T-cell large granular lymphocytic leukemia can occur after autologous stem cell transplantation.
authors.affiliation: The First Department of Internal Medicine, Ehime University School of Medicine, Ehime, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Narumi
authors.forename: K
authors.initials: K
authors.lastname: Kojima
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuo
authors.forename: H
authors.initials: H
authors.lastname: Shikata
authors.forename: K
authors.initials: K
authors.lastname: Sekiya
authors.forename: T
authors.initials: T
authors.lastname: Niiya
authors.forename: S
authors.initials: S
authors.lastname: Bando
authors.forename: H
authors.initials: H
authors.lastname: Niiya
authors.forename: T
authors.initials: T
authors.lastname: Azuma
authors.forename: Y
authors.initials: Y
authors.lastname: Yakushijin
authors.forename: I
authors.initials: I
authors.lastname: Sakai
authors.forename: M
authors.initials: M
authors.lastname: Yasukawa
authors.forename: S
authors.initials: S
authors.lastname: Fujita
mesh_terms: D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000150:complications* / Q000628:therapy; D016130:Immunophenotyping; D007945:Leukemia, Lymphoid / Q000175:diagnosis / Q000209:etiology*; D015458:Leukemia, T-Cell / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D013997:Time Factors; D014182:Transplantation, Autologous