[Clinical observation on effect of fuzheng yiliu granule on cell cycle and nuclear transcription factor-kappa B in tissue of esophageal-gastric carcinoma].
OBJECTIVE
To observe the effect of Fuzheng Yiliu Granule (FZYLG) on cell cycle and nuclear transcription factor-kappa B (NF-kappa B) in tissue of esophageal-gastric carcinoma.


METHODS
Seventy-six patients with esophageal gastric carcinoma were randomly divided into two groups, the FZYLG group and the control group. FZYLG was given to the former for 15 days. The tumor tissue in both groups was resected and cell cycle and apoptosis rate as well as NF-kappa B were determined by flowcytometry.


RESULTS
Level of NF-kappa B in the treated group was significantly higher than that in the control group (P < 0.05). In the treated group, the percentage of G0/G1 stage cells were significantly increased and that of S stage significantly decreased (both P < 0.05). At the same time, obvious cell apoptosis was found in the treated group, the apoptosis rate of which was significantly higher than that in the control group (P < 0.01).


CONCLUSIONS
FZYLG can increase the NF-kappa B expression, block the proliferation to promote the apoptosis of tumor cells.
Zhao
Jian-xiong
JX
Institute of Integrative Chinese and Western Medicine, Lanzhou Medical College, Lanzhou 730000. Zhaojianxiong@mail.Lazmc.edu.cn
Qu
Yong
Y
Chen
Xue-zhong
XZ
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology; D002453:Cell Cycle / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000378:metabolism*; D008517:Phytotherapy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
D004365:Drugs, Chinese Herbal; D016328:NF-kappa B