title: A new synthesis of lysergic acid.
abstract: [reaction: see text] (+/-)-Lysergic acid has been synthesized via an economical 8-step route from 4-bromoindole and isocinchomeronic acid without the need to protect the indole during the synthesis. Initial efforts to form the simpler 3-acylindole derivatives first and then cyclize these were unsuccessful in the cyclization step.
authors.affiliation: Department of Chemistry, Brandeis University, Waltham, Massachusetts 02454-9110, USA. hendrickson@brandeis.edu
authors.forename: James B
authors.initials: JB
authors.lastname: Hendrickson
authors.forename: Jian
authors.initials: J
authors.lastname: Wang