title: Polymorphisms of GSTT1 and related genes in head and neck cancer risk.
abstract: BACKGROUND
  Glutathione S-transferase T1 detoxifies some environmental carcinogens while activating others and is deleted in 15% to 38% of humans. We sought to determine whether GSTT1 genotype and genotypes of several related genes are associated with risk of squamous cell carcinoma of the head and neck (HNSCC).
  
  
  METHODS
  Somatic genotypes for GSTT1, GSTM1, GSTP1, and CYP1A1 were determined in 283 individuals with HNSCC and 208 population-based controls.
  
  
  RESULTS
  The OR for presence of GSTT1 was 1.6 (CI, 1.1-2.5, p = 0.03). HNSCC risk was not associated with GSTM1 null genotype, the presence of the GSTP1 Val/Val genotype, or the Val/Val homozygous genotype for CYP1A1. Stratified analysis revealed disparate ORs for women (OR, 3.0; CI, 1.5-6.3) and men (OR, 1.2; CI, 0.7-2.1) for the presence of GSTT1.
  
  
  CONCLUSIONS
  In this population, the presence of GSTT1 gene was associated with a significant increase in the risk of HNSCC. This association was particularly robust in women.
authors.affiliation: Division of Hematology and Medical Oncology, Oregon Health and Science University, Mail Code L586, Portland, Oregon 97201, USA.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Evans
authors.forename: William David
authors.initials: WD
authors.lastname: Henner
authors.forename: Kristi M
authors.initials: KM
authors.lastname: Eilers
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Montalto
authors.forename: Emily M
authors.initials: EM
authors.lastname: Wersinger
authors.forename: Peter E
authors.initials: PE
authors.lastname: Andersen
authors.forename: James I
authors.initials: JI
authors.lastname: Cohen
authors.forename: Edwin C
authors.initials: EC
authors.lastname: Everts
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: McWilliams
authors.forename: Tomasz M
authors.initials: TM
authors.lastname: Beer
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000453:epidemiology; D044465:White People / Q000235:genetics
chemical_list: C413545:glutathione S-transferase T1; D005982:Glutathione Transferase