title: Hantavirus pulmonary syndrome, southern Chile.
abstract: We analyzed data from 25 consecutive patients with hantavirus pulmonary syndrome (HPS) admitted to the Puerto Montt and Osorno Regional Hospitals, southern Chile, from 1997 to 2001, emphasizing epidemiologic, clinical, radiographic, treatment, and laboratory aspects. Hemorrhage was frequent (64%), and 48% of patients showed alterations in renal function. Ten patients died (40%). We identified three groups of patients, which included the following: 1) those with the least severe form who had prodromic symptoms without pulmonary involvement; 2) those with moderate illness who had interstitial pulmonary infiltrates, usually needed supplemental nasal oxygen, were hemodynamically stable, and had an APACHE II <12 (none of whom died); and 3) those with the severe form who required mechanical ventilation, frequently had hemodynamic instability (93%), experienced a high mortality rate (77%), and had an APACHE II >12. Mild forms of HPS also exist, which are poorly known; the symptoms could be confounded with those of other viral diseases, leading to underdiagnosis.
authors.affiliation: Puerto Montt Regional Hospital, Puerto Montt, Chile. raul@telsur.cl
authors.forename: Raúl
authors.initials: R
authors.lastname: Riquelme
authors.forename: Mauricio
authors.initials: M
authors.lastname: Riquelme
authors.forename: Antoni
authors.initials: A
authors.lastname: Torres
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Rioseco
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Vergara
authors.forename: Luis
authors.initials: L
authors.lastname: Scholz
authors.forename: Andrea
authors.initials: A
authors.lastname: Carriel
mesh_terms: D018806:APACHE; D000293:Adolescent; D000328:Adult; D002677:Chile / Q000453:epidemiology; D021821:Communicable Diseases, Emerging / Q000453:epidemiology* / Q000401:mortality / Q000503:physiopathology; D004196:Disease Outbreaks; D005260:Female; D018804:Hantavirus Pulmonary Syndrome / Q000453:epidemiology* / Q000401:mortality / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged