Predisposition to alcoholism, tryptophan oxygenase activity, and structure of intron 6 in the corresponding gene of C57BL/6J, CC57BR/Mv, and BALB/cJ mice.
Crossbred CC57BR/Mv mice inherited tryptophan oxygenase gene and predisposition to alcohol consumption from parent BALB/c and C57BL mice, respectively. In CC57BR/Mv mice no relationships were found between alcohol consumption, tryptophan oxygenase activity, and single nucleotide substitutions in intron 6 of the TDO2 gene associated with predisposition to alcoholism in humans.
Kaledin
V I
VI
Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk.
Klimova
N V
NV
Vasil'ev
G V
GV
Ivanova
E A
EA
Vasil'eva
E D
ED
Il'nitskaya
S I
SI
D000437:Alcoholism / Q000235:genetics*; D000818:Animals; D001483:Base Sequence / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006824:Hybridization, Genetic; D007438:Introns; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D017384:Sequence Deletion; D014366:Tryptophan Oxygenase / Q000235:genetics* / Q000378:metabolism*
D014366:Tryptophan Oxygenase