title: Functional magnetic resonance imaging evidence for a lack of striatal dysfunction during implicit sequence learning in individuals with animal phobia.
abstract: OBJECTIVE
  This study investigated the neural substrates of implicit sequence learning in subjects with and without small animal phobia, in a follow-up to analogous studies of obsessive-compulsive disorder (OCD).
  
  
  METHODS
  Ten subjects with specific phobia and 10 healthy comparison subjects were studied by using a serial reaction time task paradigm and functional magnetic resonance imaging.
  
  
  RESULTS
  A main effect of condition (implicit sequence learning versus random sequence) was observed across diagnostic groups in the right striatum, as well as in other regions. In the striatum, the a priori region of interest, there were no significant effects of diagnosis or the interaction of diagnosis and condition.
  
  
  CONCLUSIONS
  Brain activation in the striatum of subjects with specific phobia does not significantly differ from that of normal comparison subjects during implicit sequence learning. This suggests different pathophysiological mechanisms for specific phobia in contrast to OCD, in which deficient striatal recruitment has been reproducibly found with this paradigm. This approach offers promise for demonstrating diagnostic specificity across different neuropsychiatric disorders based on the presence or absence of deficient striatal activation.
authors.affiliation: Massachusetts General Hospital, Harvard Medical School, USA.
authors.forename: Brian
authors.initials: B
authors.lastname: Martis
authors.forename: Christopher I
authors.initials: CI
authors.lastname: Wright
authors.forename: Katherine G
authors.initials: KG
authors.lastname: McMullin
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Shin
authors.forename: Scott L
authors.initials: SL
authors.lastname: Rauch
mesh_terms: D000328:Adult; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism / Q000502:physiology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D007858:Learning / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D010698:Phobic Disorders / Q000175:diagnosis* / Q000523:psychology*; D011930:Reaction Time / Q000502:physiology; D012720:Severity of Illness Index