Phagocytic activity and state of bactericidal systems in polymorphonuclear leukocytes from patients with Alzheimer's disease.
Phagocytic activity of peripheral blood neutrophils underwent phase changes in patients with Alzheimer's disease. Neutrophils retained the ability to engulf microbes, but their digestive activity decreased at the early stage of Alzheimer's disease. At the late stage we observed a decrease in the count of phagocytizing neutrophils, reduction of myeloperoxidase activity, and increase in the content of cationic proteins.
Davydova
T V
TV
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Fomina
V G
VG
Voskresenskaya
N I
NI
Doronina
O A
OA
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000276:immunology*; D001161:Arteriosclerosis / Q000150:complications; D001770:Blood Bactericidal Activity; D001798:Blood Proteins / Q000378:metabolism; D002452:Cell Count; D005260:Female; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology*; D009195:Peroxidase / Q000097:blood; D010587:Phagocytosis; D012749:Sexually Transmitted Diseases / Q000150:complications; D013211:Staphylococcus aureus; D013997:Time Factors
D001798:Blood Proteins; D009195:Peroxidase