DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia.
Two novel mutations recently have been identified in the DJ-1 gene that cause a new form of autosomal recessive, early-onset parkinsonism. Because the pathological role of this protein is unknown, we examined the issue here and report the colocalization of DJ-1 protein within a subset of pathological tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Our study extends the view that different neurodegenerative diseases may have similar pathological mechanisms, and that these processes likely include DJ-1.
Rizzu
Patrizia
P
Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands.
Hinkle
David A
DA
Zhukareva
Victoria
V
Bonifati
Vincenzo
V
Severijnen
Lies-Anne
LA
Martinez
Daniel
D
Ravid
Rivka
R
Kamphorst
Wouter
W
Eberwine
James H
JH
Lee
Virginia M-Y
VM
Trojanowski
John Q
JQ
Heutink
Peter
P
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D019556:COS Cells; D002522:Chlorocebus aethiops; D003704:Dementia / Q000378:metabolism / Q000473:pathology*; D006367:HeLa Cells; D006801:Humans; D015151:Immunoblotting; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000378:metabolism* / Q000648:ultrastructure; D047908:Intracellular Signaling Peptides and Proteins; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000378:metabolism / Q000473:pathology; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D020734:Parkinsonian Disorders / Q000378:metabolism / Q000473:pathology*; D000071617:Protein Deglycase DJ-1; D014162:Transfection; D016875:tau Proteins / Q000378:metabolism*
D047908:Intracellular Signaling Peptides and Proteins; D015513:Oncogene Proteins; D016875:tau Proteins; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1