Viral bioinformatics: computational views of host and pathogen.
Wherever cellular life occurs, viruses are also found. As a result, complex organism and cellular antiviral responses co-evolve with virally encoded countermeasures. Since viruses co-opt or interfere with specific cellular pathways during their replication, knowledge of viral genome sequences has helped fundamental understanding of host biology. During viral infection, shifts in the balance between host and viral biological processes result in acute or chronic viral disease pathology accompanied with either active viral replication, viral containment/persistence or viral clearance. Studying host-virus interactions at the level of single gene effects, however, fails to produce a global systems-level understanding. This should now be achievable in the context of complete host and pathogen genome sequences. New experimental methods and computational approaches are rapidly developing, allowing global views of dynamic viral and cellular molecular mechanisms. Systems level virology using DNA microarrays and specific viral data resources will reveal the detailed cellular context in which viruses replicate, highlighting common and distinct antiviral mechanisms, the effect of different host cell gene expression programs, and the response of cells to similar or diverse virus types. Ultimately, microbiology and immunology will tend towards a systems-level view of how host and pathogen interact.
Kellam
Paul
P
Virus Genomics and Bioinformatics Group, Department of Immunology and Molecular Pathology, University College, Windeyer Institute of Medical Sciences, 46 Cleveland Street, London W1T4JF, UK.
Holzerlandt
Ria
R
Gramoustianou
Eva
E
Jenner
Richard
R
Kwan
Antonia
A
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D019295:Computational Biology; D030541:Databases, Genetic; D016679:Genome, Viral; D023281:Genomics / Q000706:statistics & numerical data; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology; D014773:Virology / Q000706:statistics & numerical data; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology; D014780:Viruses / Q000235:genetics / Q000276:immunology
D014764:Viral Proteins