title: Summing up ligand binding interactions.
abstract: Artificial molecular recognition systems show negligible positive binding cooperativity compared to biological systems, possibly because rigid ligands cannot accommodate numerous partly bound states that comprise overall ligand binding affinity. This directly correlates with the phenomenon of enthalpy-entropy compensation.
authors.affiliation: School of Chemistry, University of Edinburgh, The King's Buildings, West Mains Road, Edinburgh EH9 3JJ, UK.
authors.forename: David A
authors.initials: DA
authors.lastname: Leigh
mesh_terms: D000494:Allosteric Regulation; D008024:Ligands; D013816:Thermodynamics
chemical_list: D008024:Ligands