title: An unusual etiology of viral hepatitis in three renal transplant recipients with normal graft function.
abstract: Liver impairment in renal transplant recipients is not a common complication and is associated, in most cases, with viral infections (HBV, HCV, HVD, HGV) or drug hepatotoxicity (Cyclosporin, Azathioprine, statins). Cytomegalovirus (CMV) infection is common, with 50 to 80% of the adult population being seropositive for CMV antibodies. In immunocompetent individuals, primary infection is usually asymptomatic or associated with minor illness. CMV remains latent after primary infection. In immunocompromised patients, as in renal transplant recipients or transplant recipients of other solid organ or bone marrow, the virus can cause serious disease. This could be the result of newly acquired infection or reactivation of the latent virus. One of the organs involved in CMV disease is the liver. The subjects of this report are renal transplant recipients with liver impairment due to CMV induced acute hepatitis.
authors.affiliation: Department of Internal Medicine - Nephrology, Fundeni Institute, Bucharest, Romania.
authors.forename: Camelia
authors.initials: C
authors.lastname: Ionescu
authors.forename: Gener
authors.initials: G
authors.lastname: Ismail
authors.forename: Ileana
authors.initials: I
authors.lastname: Constantinescu
authors.forename: Monica
authors.initials: M
authors.lastname: Hortopan
authors.forename: Olguta
authors.initials: O
authors.lastname: Iliescu
authors.forename: Mihaela
authors.initials: M
authors.lastname: Rosu
authors.forename: Mihai
authors.initials: M
authors.lastname: Voiculescu
mesh_terms: D000293:Adolescent; D000328:Adult; D003586:Cytomegalovirus Infections / Q000175:diagnosis*; D005260:Female; D006525:Hepatitis, Viral, Human / Q000175:diagnosis* / Q000821:virology; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged