title: Binding of imidazole-derived nucleosides to a CG base pair.
abstract: Novel imidazole nucleosides with substituents of different flexibility were studied for their binding to a CG Watson-Crick base pair by (1)H NMR spectroscopy in an aprotic solvent. Thermodynamic data as determined by titration experiments at different temperatures reveal the influence of the substituent on the enthalpy and entropy of complex formation and thus on the strength of binding.
authors.affiliation: Institut für Chemie und Biochemie, Ernst-Moritz-Arndt-Universität Greifswald, Soldmannstrasse 16, D-17489 Greifswald, Germany.
authors.forename: Maria G M
authors.initials: MG
authors.lastname: Purwanto
authors.forename: Klaus
authors.initials: K
authors.lastname: Weisz
mesh_terms: D020029:Base Pairing; D007093:Imidazoles / Q000737:chemistry*; D009705:Nucleosides / Q000737:chemistry*; D013696:Temperature
chemical_list: D007093:Imidazoles; D009705:Nucleosides