title: [The relationship between transforming growth factor-beta1, platelet derived growth factor and airway remodeling in eosinophilic bronchitis].
abstract: OBJECTIVE
  To study the relationship between the expression of transforming growth factor-beta(1) (TGF-beta(1)) and platelet derived growth factor (PDGF) and airway remodeling in eosinophilic bronchitis (EB).
  
  
  METHODS
  Bronchial biopsy specimens were obtained from 12 patients with EB (A group), 10 asthmatic patients (B group) and 10 patients (C group) with peripheral lung cancer in early stage. The subepithelial basement membrane (SBM) thickness was measured by light microscopy using HE staining. The expressions of TGF-beta(1) and PDGF in the bronchial mucosa were examined by immunostaining.
  
  
  RESULTS
  The SBM of A group [(6.3 +/- 1.4) micro m] was significantly thicker than that of C group [(4.1 +/- 1.2) micro m, P < 0.05], but significantly thinner than that of B group [(8.2 +/- 1.5) micro m]. The numbers of positive cells for TGF-beta(1) and PDGF in A group (59 +/- 9, 47 +/- 7 respectively) and B group (85 +/- 12, 76 +/- 11, respectively) were significantly higher than those in C group (31 +/- 4, 20 +/- 3, respectively), and were positively correlated with SBM thickness (r = 0.76, 0.52, P < 0.05).
  
  
  CONCLUSIONS
  These results suggest that TGF-beta(1) and PDGF expressions in bronchial mucosa may play a role in bronchial subepithelial fibrosis in EB patients.
authors.affiliation: Department of Respiratory Medicine, Shandong Provincial Hospital, Jinan 250021, China.
authors.forename: Huai-chen
authors.initials: HC
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.forename: Chen
authors.initials: C
authors.lastname: Huang
authors.forename: Mao-fen
authors.initials: MF
authors.lastname: Wang
authors.forename: Shu-juan
authors.initials: SJ
authors.lastname: Jiang
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Mu
authors.forename: Dian-jie
authors.initials: DJ
authors.lastname: Lin
authors.forename: Xiang-yu
authors.initials: XY
authors.lastname: Chi
authors.forename: Li-li
authors.initials: LL
authors.lastname: Su
authors.forename: Ling
authors.initials: L
authors.lastname: Zhu
authors.forename: Cai-qing
authors.initials: CQ
authors.lastname: Zhang
mesh_terms: D000328:Adult; D001991:Bronchitis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000032:analysis*; D011657:Pulmonary Eosinophilia / Q000378:metabolism / Q000473:pathology*; D020545:Respiratory Mucosa / Q000737:chemistry / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000032:analysis*
chemical_list: D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta