Effect of vitamins C and E on cognitive function in mouse.
The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250mg/kg per day) or Vitamin C (300mg/kg per day) for 60 days. Third group was treated with the combination of Vitamin E (250mg/kg per day) and Vitamin C (300mg/kg per day) for 60 days. The control group received only vehicle. The aged animal group (aged 15 months) were treated as the young group. Passive avoidance method was used for the assessment of cognitive function in both young and aged animals. The results indicated a significant improvement in the cognitive function of aged mice while there were no significant changes in young animals.
Arzi
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Department of Pharmacology and Toxicology, School of Pharmacy, Ahwaz University of Medical Sciences, Ahwaz, Iran.
Hemmati
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AA
Razian
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D000375:Aging / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D014810:Vitamin E / Q000494:pharmacology*
D014810:Vitamin E; D001205:Ascorbic Acid