title: Epidemiology of human papillomavirus infection and abnormal cytologic test results in an urban adolescent population.
abstract: We determined the prevalence of and the risk factors for human papillomavirus (HPV) infection and abnormal cytologic test results in 312 adolescent girls (mean age, 16.1 years). Subjects had a median of 2 years of sexual activity and 4 lifetime sex partners. Cervical HPV was detected by use of L1-consensus polymerase chain reaction in 64% of subjects; half of those with HPV had >1 type, and 77% had >/=1 high-risk type. Independent risk factors for HPV were lifetime number of sex partners, age of partner, and douching. Cytologic abnormalities were common (20.9% of subjects had atypical squamous cells of uncertain significance, and 17.0% had high- or low-grade squamous intraepithelial lesions) and were significantly associated with detection of HPV (P=.0001); however, most (51.6%) subjects with HPV had normal cytologic test results.
authors.affiliation: National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia, USA.
authors.forename: Trudee A
authors.initials: TA
authors.lastname: Tarkowski
authors.forename: Emilia H
authors.initials: EH
authors.lastname: Koumans
authors.forename: Mary
authors.initials: M
authors.lastname: Sawyer
authors.forename: Antonya
authors.initials: A
authors.lastname: Pierce
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Black
authors.forename: John R
authors.initials: JR
authors.lastname: Papp
authors.forename: Lauri
authors.initials: L
authors.lastname: Markowitz
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Unger
mesh_terms: D000293:Adolescent; D036022:Capsid Proteins; D005260:Female; D005838:Genotype; D005845:Georgia / Q000453:epidemiology; D006801:Humans; D015999:Multivariate Analysis; D009856:Oncogene Proteins, Viral / Q000032:analysis; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012307:Risk Factors; D012725:Sexual Behavior; D011795:Surveys and Questionnaires; D014505:Urban Population; D002577:Uterine Cervical Diseases / Q000453:epidemiology* / Q000821:virology; D014626:Vaginal Smears / Q000706:statistics & numerical data*
chemical_list: D036022:Capsid Proteins; D009856:Oncogene Proteins, Viral; C063317:L1 protein, Human papillomavirus type 16