title: The sticking point: How integrins bind to their ligands.
abstract: The integrin adhesion receptors are alpha beta heterodimers that exist in different ligand-binding states. Because of their large size and conformational lability, it has been difficult to determine how they interact with their ligands. Ligand-binding sites have been identified in the beta subunit, and now more recently in the 'I' domain and EF-hand-like domains V and VI of the alpha subunit. We speculate here about how these various sites might operate together to bind ligand in a stable manner.
authors.affiliation: Imperial Cancer Research Fund, Lincolm's Inn Fields, London, UK WC2A 3PX.
authors.forename: N
authors.initials: N
authors.lastname: Hogg
authors.forename: R
authors.initials: R
authors.lastname: Clive Landis
authors.forename: P A
authors.initials: PA
authors.lastname: Bates
authors.forename: P
authors.initials: P
authors.lastname: Stanley
authors.forename: A M
authors.initials: AM
authors.lastname: Randi