title: Levalbuterol compared with racemic albuterol in the treatment of acute asthma: results of a pilot study.
abstract: This was a prospective, open-label, nonrandomized pilot study to evaluate efficacy and tolerability of levalbuterol (LEV) in acute asthma. Asthmatics (forced expiratory volume in 1 second [FEV1], 20-55% predicted) were sequentially enrolled into cohorts of 12 to 14 and received 0.63, 1.25, 2.5, 3.75, or 5.0 mg LEV or 2.5 or 5.0 mg racemic albuterol (RAC) every 20 minutes x 3. After the first dose, FEV1 changes were 56% (0.6 L) for 1.25 mg LEV and 6% (0.07 L) and 14% (0.21 L) for 2.5 and 5 mg RAC respectively. After three doses, FEV1 changes were 74% (0.9 L), 39% (0.5 L), and 37% (0.6 L) for 1.25 mg, LEV 2.5 mg, RAC and 0.63 mg LEV respectively. LEV doses greater than 1.25 mg did not further improve bronchodilation. Baseline plasma (S)-albuterol levels were negatively correlated with baseline FEV1 (R = - 0.3, P = .004) and percent change in FEV1 (R = -0.3, P = .006). LEV at a dose of 1.25 mg produced effective bronchodilation that was greater than both RAC doses. The negative correlation between (S)-albuterol levels and FEV1 could suggest a deleterious effect of (S)-albuterol. Larger comparative studies are warranted.
authors.affiliation: Henry Ford Health System, Detroit, Michigan 48202, USA. rnowak1@hfhs.org
authors.forename: Richard M
authors.initials: RM
authors.lastname: Nowak
authors.forename: Charles L
authors.initials: CL
authors.lastname: Emerman
authors.forename: Kendyl
authors.initials: K
authors.lastname: Schaefer
authors.forename: Rachel L
authors.initials: RL
authors.lastname: Disantostefano
authors.forename: Louis
authors.initials: L
authors.lastname: Vaickus
authors.forename: James M
authors.initials: JM
authors.lastname: Roach
mesh_terms: D000208:Acute Disease; D000328:Adult; D000420:Albuterol / Q000627:therapeutic use*; D000704:Analysis of Variance; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D010865:Pilot Projects; D011446:Prospective Studies; D013237:Stereoisomerism; D016896:Treatment Outcome
chemical_list: D001993:Bronchodilator Agents; D000420:Albuterol