title: Fluorescence detection of guanine-adenine transition by a hydrogen bond forming small compound.
abstract: In combination with abasic site-containing oligodeoxynucleotides, 2-amino-4-oxopteridine (pterin) can selectively recognize guanine base over other nucleobases accompanied by fluorescence quenching, which allows clear detection of a guanine-adenine transition with the naked eye.
authors.affiliation: Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan.
authors.forename: Keitaro
authors.initials: K
authors.lastname: Yoshimoto
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Xu
authors.forename: Seiichi
authors.initials: S
authors.lastname: Nishizawa
authors.forename: Takanobu
authors.initials: T
authors.lastname: Haga
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Satake
authors.forename: Norio
authors.initials: N
authors.lastname: Teramae
mesh_terms: D000225:Adenine / Q000737:chemistry*; D001483:Base Sequence; D001665:Binding Sites; D006147:Guanine / Q000737:chemistry* / Q000378:metabolism; D006860:Hydrogen Bonding; D009691:Nucleic Acid Denaturation; D009692:Nucleic Acid Heteroduplexes / Q000737:chemistry; D009838:Oligodeoxyribonucleotides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011621:Pteridines / Q000737:chemistry* / Q000378:metabolism; D013050:Spectrometry, Fluorescence; D013696:Temperature
chemical_list: D009692:Nucleic Acid Heteroduplexes; D009838:Oligodeoxyribonucleotides; D011621:Pteridines; D006147:Guanine; D000225:Adenine