A mitotic function for Src?
During mitosis, the activity of the c-Src protein tyrosine kinase increases. The tyrosine phosphorylation of a 68 kDa protein (Sam68) also increases at this time, and recent studies have shown that Src and Sam68 interact. Sam68 is highly related to p62, a RasGAP-associated protein, and has homology to RNA-binding proteins. The relationship between p62 and Sam68, and their roles in Src signalling, need to be clarified, but these findings suggest that Src may participate in regulating RNA processing during the cell cycle.
Courtneidge
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Differentiation Programme, European Molecular Biology Laboratory, Postfach 16.2209, Meyerhofstrasse 1, 69012 Heidelberg, Germany.
Fumagalli
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