Microbiology of recurrent acute rhinosinusitis.
OBJECTIVE
We undertook to evaluate the microbiology of recurrent acute rhinosinusitis.


METHODS
Repeated aspirations of maxillary sinus secretions by endoscopy were performed in eight patients over a period of 98 to 185 days.


RESULTS
Bacteria were recovered for all 25 aspirates. A total of 31 isolates-14 Streptococcus pneumoniae, 11 Haemophilus influenzae, 5 Moraxella catarrhalis, and 1 Staphylococcus aureus-were recovered. The organism persisted in consecutive cultures in 13 instances and were eliminated in 8, and new organisms emerged in 6 instances. An increase in antimicrobial resistance was noted in 5 instances (3 in S. pneumoniae and 2 H. influenzae).


CONCLUSIONS
This study illustrates the microbial dynamics of recurrent acute rhinosinusitis, with the changes in microbial findings and increased bacterial resistance that occurs over time.
Brook
Itzhak
I
Department of Pediatrics, Georgetown University, Washington, DC, USA. ib6@georgetown.edu
Frazier
Edith H
EH
D000208:Acute Disease; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy; D006192:Haemophilus Infections / Q000175:diagnosis / Q000188:drug therapy; D006193:Haemophilus influenzae / Q000302:isolation & purification; D006801:Humans; D008297:Male; D015523:Maxillary Sinusitis / Q000188:drug therapy / Q000382:microbiology*; D008875:Middle Aged; D001936:Moraxella catarrhalis / Q000302:isolation & purification; D011008:Pneumococcal Infections / Q000175:diagnosis / Q000188:drug therapy; D012008:Recurrence; D012220:Rhinitis / Q000188:drug therapy / Q000382:microbiology*; D013997:Time Factors
D000900:Anti-Bacterial Agents