[Comparative evaluation of cardiac hemodynamics and endothelium-dependent reactive hyperemia in people with arterial hypertension living in high-altitude and plain areas].
OBJECTIVE
To reveal the specific features of cardiac hemodynamics and endothelial function in high-altitude native dwellers with arterial hypertension (AH).


METHODS
90 native dwellers from high-altitude and plain areas, who had Stages I and II AH, were examined. To assess cardiac contractility, central and peripheral hemodynamics, the authors used electrocardiography, echocardiography, tetrapolar impedance rheoplethysmography. The functional status of the endothelium was evaluated by the reproduction of endothelium-dependent reactive hyperthermia in the antebrachial vessels.


RESULTS
The patients with Stages I and II AH who live in high-altitude area have been found to have less pronounced peripheral vasocontriction due to the less suppression of pump and contractile functions of the heart. Total peripheral resistance in high-altitude dwellers with Stage II AH is practically similar to that in plain inhabitants with Stage I AH. The extended vasodilator reserve in high-altitude inhabitants with AH is also shown by the data obtained in the reproduction of reactive hyperemia in the antebrachial vessels. A less marked decrease in this vascular reaction in patients with AH who live in high-altitude areas may be due to additional production and/or release of nitric oxide in order to increase the vasodilator reserve in moderate hypoxia.


CONCLUSIONS
The course of AH in high-altitude dwellers is marked by less suppression of cardiac pump and contractile functions and less peripheral vasoconstriction. This may be accounted for by compensatory activation of endothelial vasodilator mechanisms aimed at preserving adequate tissue perfusion and at optimally providing the body with oxygen in moderate hypoxia.
Doloman
L B
LB
Beslaneev
I A
IA
Batyrbekova
L M
LM
Kurdanov
Kh A
KhA
Sagach
V F
VF
D000064:Acclimatization / Q000502:physiology*; D000368:Aged; D000531:Altitude; D003326:Coronary Circulation / Q000502:physiology; D003331:Coronary Vessels / Q000502:physiology; D004452:Echocardiography; D004562:Electrocardiography; D004730:Endothelium, Vascular / Q000502:physiology; D005260:Female; D006321:Heart / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D006940:Hyperemia / Q000209:etiology / Q000503:physiopathology*; D006973:Hypertension / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged