Sarcoidosis in HIV-infected patients in the era of highly active antiretroviral therapy.
To analyze the impact of highly active antiretroviral therapy (HAART) on the characteristics and outcome of sarcoidosis in patients infected with human immunodeficiency virus (HIV), we identified HIV-infected patients in whom sarcoidosis was diagnosed between 1996 and 2000 from the admission registers of the pneumology departments of 12 hospitals in the Paris region (France). Sarcoidosis was diagnosed in 11 HIV-infected patients, of whom 8 were receiving HAART. HIV infection was diagnosed before sarcoidosis in 9 cases. At diagnosis of sarcoidosis, the mean CD4 cell count (+/-SD) was 390+/-213 cells/mm(3), and the mean plasma virus load was 4002+/-10,183 copies/mL. Sarcoidosis occurred several months after HAART introduction, when the CD4 cell count had increased and the plasma HIV load had decreased. Clinical and radiological characteristics, laboratory values for bronchoalveolar lavage fluid samples, and outcome after a long follow-up were similar for the patients receiving HAART and for HIV-uninfected patients.
Foulon
Guillaume
G
Service de Pneumologie et Réanimation Respiratoire, Hôpital Tenon, Paris, France.
Wislez
Marie
M
Naccache
Jean-Marc
JM
Blanc
François-Xavier
FX
Rabbat
Antoine
A
Israël-Biet
Dominique
D
Valeyre
Dominique
D
Mayaud
Charles
C
Cadranel
Jacques
J
D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D006678:HIV; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000503:physiopathology; D013997:Time Factors; D016896:Treatment Outcome
D019380:Anti-HIV Agents