title: Urinary cyclic GMP excretion and blood pressure levels in a general population.
abstract: Dysfunction of the nitric oxide (NO) system is potentially involved in the development of hypertension, but only limited data are currently available from experimental or clinical studies. We investigated cross-sectionally the relation between urinary excretion of cyclic guanosine 3',5'-monophosphate (cyclic GMP), a second messenger of NO, and hypertension in a general population sample of Japanese men and women. The samples comprised 1541 subjects (788 men and 753 women) aged 40-79 years who participated in cardiovascular risk surveys between 1997 and 2002 and underwent a 24h urine collection. Urinary excretion of cyclic GMP was measured using a 125I-labeled cyclic GMP radioimmunoassay, and was adjusted for urinary creatinine excretion (nmol/mmol creatinine). Urinary cyclic GMP excretion was 66.0+/-62.0nmol/mmol creatinine (mean+/-S.D.). Compared with normal blood pressure individuals, the multivariate-adjusted mean value of urinary cyclic GMP excretion was significantly higher in people with moderate hypertension, but not higher in severe hypertension. Among subjects with hypertensive end-organ damage, we observed reduced urinary cyclic GMP excretion in severe hypertension and no increased excretion in moderate hypertension, compared with normal blood pressure. Although we had the limited number of subjects with severe hypertension (n=15), our data suggest that NO bioactivity may be increase in the early stage of hypertension but decreased in severe hypertension with end-organ damage.
authors.affiliation: Department of Public Health Medicine, Institute of Community Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Renzhe
authors.initials: R
authors.lastname: Cui
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
authors.forename: Jingbo
authors.initials: J
authors.lastname: Pi
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Kumagai
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Yamagishi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tanigawa
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Shimojo
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimamoto
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D003404:Creatinine / Q000652:urine; D003430:Cross-Sectional Studies; D006152:Cyclic GMP / Q000652:urine*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000652:urine*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
chemical_list: D003404:Creatinine; D006152:Cyclic GMP