Age and variant Creutzfeldt-Jakob disease.
The young and stable median age of those who die of variant Creutzfeldt-Jakob disease has been attributed to age-dependent infection rates. This analysis shows that an influence of age on risk for death after infection better explains age patterns, suggesting that biologic factors peaking in the third decade of life may hasten disease.
Bacchetti
Peter
P
Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94143-0560, USA. peter@biostat.ucsf.edu
D000328:Adult; D000367:Age Factors; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology* / Q000401:mortality; D006801:Humans; D008954:Models, Biological