Toxoplasma gondii and schizophrenia.
Recent epidemiologic studies indicate that infectious agents may contribute to some cases of schizophrenia. In animals, infections with Toxoplasma gondii can alter behavior and neurotransmitter function. In humans, acute infection with T. gondii can produce psychotic symptoms similar to those displayed by persons with schizophrenia. Since 1953, a total of 19 studies of T. gondii antibodies in persons with schizophrenia and other severe psychiatric disorders and in controls have been reported; 18 reported a higher percentage of antibodies in the affected persons; in 11 studies the difference was statistically significant. Two other studies found that exposure to cats in childhood was a risk factor for the development of schizophrenia. Some medications used to treat schizophrenia inhibit the replication of T. gondii in cell culture. Establishing the role of T. gondii in the etiopathogenesis of schizophrenia might lead to new medications for its prevention and treatment.
Torrey
E Fuller
EF
Stanley medical REsearch Institute, Bethesda, Maryland 20814-2142, USA. torreyf@stanleyresearch.org
Yolken
Robert H
RH
D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D001921:Brain / Q000473:pathology; D002648:Child; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000097:blood / Q000209:etiology* / Q000469:parasitology; D014122:Toxoplasma / Q000276:immunology* / Q000472:pathogenicity; D014123:Toxoplasmosis / Q000150:complications* / Q000453:epidemiology / Q000635:transmission
D000913:Antibodies, Protozoan