title: Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: donor type matters.
abstract: Hemorrhagic cystitis (HC) remains a common complication of allogeneic blood and marrow transplantation. Previous analyses of risk factors for this complication were performed in heterogeneous populations, with dissimilar diagnosis and conditioning regimens. We postulated that HC is more prevalent in matched unrelated donor (MUD) and unrelated cord blood (UCB) transplantations than in matched related donor (MRD) transplantations. We performed a retrospective study on 105 acute lymphocytic leukemia patients treated with 12 Gy total body irradiation-based regimens and allogeneic transplants (MUD, n = 38; UCB, n = 15; mismatched related, n = 20; MRD, n = 32). HC occurred in 16% of patients receiving MRD transplants, 30% of recipients of mismatched related, and 40% of MUD or UCB transplants (hazard ratio 2.9, 95% CI 1.0-7.9 for the comparison of MRD versus MUD). The excessive rate of HC among MUD and UCB patients became evident after the first 30 days after transplantation. Recipients younger than 26 years had a significantly higher incidence of HC (HR 2.5, 95% CI 1.1-5.8). This donor type and age effect was independent of platelet engraftment, development of graft-versus-host disease (GVHD), source of stem cells, use of anti-thymocyte globulin (ATG) or cyclophosphamide in the regimen, steroid use, or stem cell source. We concluded that HC is more prevalent in MUD and UCB transplantations.
authors.affiliation: Department of Blood and Marrow Transplantation, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 423, Houston, TX 77030, USA.
authors.forename: Maha
authors.initials: M
authors.lastname: El-Zimaity
authors.forename: Rima
authors.initials: R
authors.lastname: Saliba
authors.forename: Kawah
authors.initials: K
authors.lastname: Chan
authors.forename: Munir
authors.initials: M
authors.lastname: Shahjahan
authors.forename: Antonio
authors.initials: A
authors.lastname: Carrasco
authors.forename: Ola
authors.initials: O
authors.lastname: Khorshid
authors.forename: Humberto
authors.initials: H
authors.lastname: Caldera
authors.forename: Daniel
authors.initials: D
authors.lastname: Couriel
authors.forename: Sergio
authors.initials: S
authors.lastname: Giralt
authors.forename: Issa
authors.initials: I
authors.lastname: Khouri
authors.forename: Cindy
authors.initials: C
authors.lastname: Ippoliti
authors.forename: Richard
authors.initials: R
authors.lastname: Champlin
authors.forename: Marcos
authors.initials: M
authors.lastname: de Lima
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003556:Cystitis / Q000453:epidemiology / Q000209:etiology*; D006086:Graft vs Host Disease / Q000517:prevention & control; D006474:Hemorrhagic Disorders / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015994:Incidence; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014019:Tissue Donors / Q000706:statistics & numerical data*; D014184:Transplantation, Homologous / Q000009:adverse effects
chemical_list: D007166:Immunosuppressive Agents