title: Mapping of bovine ovulation rate QTL; an analytical approach for three generation pedigrees.
abstract: Interval mapping was conducted for ovulation rate quantitative trait loci (QTL) using data from two related families from the United States Department of Agriculture, US Meat Animal Research Center twinning cattle herd. Both families are extended, three generation pedigrees from which records of sons, daughters and granddaughters were analysed. Both a method of analysis and results from that analysis are reported herein. Results from one of the two families (839802) were previously reported, but reanalysis here including the second, related family (839803) and a revised statistical model lessens support for the previously reported QTL. Results from interval mapping provided evidence for QTL in regions corresponding to those previously suggested for chromosomes 7 (chromosome-wise P < 0.05) and 19 (chromosome-wise P < 0.01) in the 839802 family, although statistical significance was reduced. In contrast to the previous report, evidence for a chromosome 5 QTL in the same family was greatly reduced while support for a QTL on chromosome 10 increased (chromosome-wise P < 0.01). Analysis of data from the related 839803 family failed to replicate evidence of QTL observed on either chromosome 7 or chromosome 19 in the 839802 family.
authors.affiliation: Animal Sciences Department, University of Wisconsin-Madison, Madison, WI 53706, USA.
authors.forename: J
authors.initials: J
authors.lastname: Arias
authors.forename: B
authors.initials: B
authors.lastname: Kirkpatrick
mesh_terms: D000383:Agriculture / Q000379:methods; D000818:Animals; D001947:Breeding / Q000379:methods; D002417:Cattle / Q000235:genetics* / Q000502:physiology; D002874:Chromosome Mapping; D003198:Computer Simulation; D005260:Female; D008957:Models, Genetic; D010060:Ovulation / Q000502:physiology*; D040641:Quantitative Trait Loci / Q000235:genetics*