title: Relationship between ciprofloxacin resistance and extended-spectrum beta-lactamase production in Escherichia coli and Klebsiella pneumoniae strains.
abstract: Resistance to fluoroquinolones has increased markedly since their introduction. Mechanisms of resistance to any antibiotic class might play a role in resistance to an unrelated antibiotic class. This study evaluated the relationship between extended-spectrum beta-lactamase (ESBL) production and ciprofloxacin resistance in Escherichia coli and Klebsiella pneumoniae strains isolated as causative agents of urinary tract infection. ESBL-producing strains were significantly more frequent among ciprofloxacin-resistant E. coli strains than among ciprofloxacin-susceptible E. coli strains (p = 0.015), but the difference was not significant among K. pneumoniae strains (p = 0.276).
authors.affiliation: Department of Microbiology and Clinical Microbiology, Istanbul Faculty of Medicine, Istanbul University, 34390 Capa, Istanbul, Turkey.
authors.forename: V
authors.initials: V
authors.lastname: Tolun
authors.forename: O
authors.initials: O
authors.lastname: Küçükbasmaci
authors.forename: D
authors.initials: D
authors.lastname: Törümküney-Akbulut
authors.forename: C
authors.initials: C
authors.lastname: Catal
authors.forename: M
authors.initials: M
authors.lastname: Anğ-Küçüker
authors.forename: O
authors.initials: O
authors.lastname: Anğ
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology; D004927:Escherichia coli Infections / Q000382:microbiology; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology; D014552:Urinary Tract Infections / Q000382:microbiology; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D001618:beta-Lactamases