Allylmercaptocaptopril: a new antihypertensive drug.
Allylmercaptocaptopril (CPSSA) was synthesized by reacting captopril with pure allicin. Fructose-induced hypertensive groups of rats were fed a fructose-rich diet for 3 weeks, and then received the diet plus either CPSSA (40 to 56 mg or 138 to 194 micromol/L/kg/d) or captopril (80 mg or 369 micromol/L/kg/d) for 2 more weeks. CPSSA (both doses) significantly lowered blood pressure (BP) from 153.4 to 120.8 mm Hg (P <.005). Captopril gave similar results, lowering BP from 150.7 to 123 mm Hg (P <.005). CPSSA also decreased the high levels of triglycerides to normal. The new stable compound allylmercaptocaptopril combines the beneficial properties of captopril and allicin and is a potential candidate for antihypertensive drug therapy.
Miron
Talia
T
Weizmann Institute of Science, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Rabinkov
Aharon
A
Peleg
Edna
E
Rosenthal
Talma
T
Mirelman
David
D
Wilchek
Meir
M
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000737:chemistry; D004195:Disease Models, Animal; D004220:Disulfides; D005632:Fructose / Q000009:adverse effects; D006973:Hypertension / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D013441:Sulfinic Acids / Q000737:chemistry; D014280:Triglycerides / Q000097:blood
D000959:Antihypertensive Agents; D004220:Disulfides; D000960:Hypolipidemic Agents; D007328:Insulin; D013441:Sulfinic Acids; D014280:Triglycerides; D005632:Fructose; C006452:allicin; D002216:Captopril