Human umbilical cord blood (HUCB) cells for central nervous system repair.
Cellular therapy is a compelling and potential treatment for certain neurological and neurodegenerative diseases as well as a viable treatment for acute injury to the spinal cord and brain. The hematopoietic system offers alternative sources for stem cells compared to those of fetal or embryonic origin. Bone marrow stromal and umbilical cord cells have been used in pre-clinical models of brain injury, directed to differentiate into neural phenotypes, and have been related to functional recovery after engraftment in central nervous system (CNS) injury models. This paper reviews the advantages, utilization and progress of human umbilical cord blood (HUCB) cells in the neural cell transplantation and repair field.
Newman
Mary B
MB
Center of Excellence for Aging and Brain Repair, Departments of Neurosurgery, Psychology, Psychiatry, Neurology, Pathology and Pharmacology, University of South Florida, College of Medicine, Tampa FL 33612, USA.
Davis
Cyndy D
CD
Kuzmin-Nichols
Nicole
N
Sanberg
Paul R
PR
D000818:Animals; D002493:Central Nervous System Diseases / Q000628:therapy*; D036101:Cord Blood Stem Cell Transplantation; D006801:Humans; D007231:Infant, Newborn; D009474:Neurons / Q000502:physiology; D010641:Phenotype; D051381:Rats