Apoptosis, complement and systemic lupus erythematosus: a mechanistic view.
Deficiencies in the classical pathway of the complement system have been implicated in the etiology and pathogenesis of systemic lupus erythematosus (SLE) for several decades. Recent advances have suggested that this link is due to a critical role of complement in the recognition and clearance of the cellular remnants of apoptosis. In this review, we summarize the role of apoptosis in generation of an autoimmune response, and we integrate recent advances that link apoptosis, complement activation and the etiopathogenesis of SLE.
Liu
Chau-Ching
CC
Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Lupus Center of Excellence, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pa., USA.
Navratil
Jeannine S
JS
Sabatine
Janice M
JM
Ahearn
Joseph M
JM
D000818:Animals; D017209:Apoptosis; D001324:Autoantigens / Q000378:metabolism; D015551:Autoimmunity; D003165:Complement System Proteins / Q000502:physiology*; D006801:Humans; D007108:Immune Tolerance; D008180:Lupus Erythematosus, Systemic / Q000209:etiology* / Q000276:immunology; D010766:Phosphorylation
D001324:Autoantigens; D003165:Complement System Proteins