title: Acromegaly with fibrous dysplasia: McCune-Albright Syndrome -- clinical studies in 3 cases and brief review of literature--.
abstract: The McCune-Albright syndrome (MAS) is characterized by a triad of poly/monostotic fibrous dysplasia, café-au-lait macules and hyperfunctioning endocrinopathies including growth hormone (GH) excess. Polyostotic bone lesions and café-au-lait macules are common while monostotic bone lesions are rare. Similarly, acromegaly as a manifestation of endocrine hyperfunction with MAS is uncommon and in most of the instances somatotropinoma has not been documented. We report 3 patients, two of them had monostotic lesion, none had café-au-lait macules and all had GH secreting pituitary macroadenoma. All of them underwent transfrontal pituitary adenomectomy and had histopathological confirmation of GH secreting pituitary adenoma. A brief review of literature is also presented.
authors.affiliation: Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Anil
authors.initials: A
authors.lastname: Bhansali
authors.forename: Bhawani S
authors.initials: BS
authors.lastname: Sharma
authors.forename: Polupoina
authors.initials: P
authors.lastname: Sreenivasulu
authors.forename: Paramjit
authors.initials: P
authors.lastname: Singh
authors.forename: Rakesh K
authors.initials: RK
authors.lastname: Vashisth
authors.forename: Radharaman J
authors.initials: RJ
authors.lastname: Dash
mesh_terms: D000172:Acromegaly / Q000150:complications*; D000236:Adenoma / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery; D000328:Adult; D005358:Fibrous Dysplasia, Monostotic / Q000150:complications*; D005359:Fibrous Dysplasia, Polyostotic / Q000150:complications*; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D019382:Human Growth Hormone