title: Cyrmenins, new beta-methoxyacrylate inhibitors of the electron transport. Production, isolation, physico-chemical and biological properties.
abstract: New antibiotic compounds, named cyrmenins, were isolated from the culture broth of strains of the myxobacteria Cystobacter armeniaca and Archangium gephyra. The compounds belong to the group of beta-methoxyacrylate (MOA) inhibitors and are the first naturally occuring nitrogen-linked MOAs. The cyrmenins show nearly the same antifungal activity as strobilurin A, but are less toxic in a growth inhibition assay with L929 mouse cells. Cyrmenins inhibit NADH oxidation by submitochondrial particles from beef heart. Investigations by difference spectroscopy showed that cyrmenin B1 blocks the electron transport within the cytochrome bc1-segment (complex III) of the respiratory chain.
authors.affiliation: GBF, German Research Centre for Biotechnology, Department of Natural Product Biology, Mascheroder Weg I, D-38124 Braunschweig, Germany. fsa@gbf.de
authors.forename: Florenz
authors.initials: F
authors.lastname: Sasse
authors.forename: Thomas
authors.initials: T
authors.lastname: Leibold
authors.forename: Brigitte
authors.initials: B
authors.lastname: Kunze
authors.forename: Gerhard
authors.initials: G
authors.lastname: Höfle
authors.forename: Hans
authors.initials: H
authors.lastname: Reichenbach
mesh_terms: D000179:Acrylates / Q000037:antagonists & inhibitors*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D004579:Electron Transport / Q000187:drug effects*; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D009231:Myxococcales; D013329:Structure-Activity Relationship
chemical_list: D000179:Acrylates; D000900:Anti-Bacterial Agents