Human herpesvirus 8 and Epstein-Barr virus-related monotypic large B-cell lymphoproliferative disorder coexisting with mixed variant of Castleman's disease in a lymph node of a renal transplant recipient.
Human herpesvirus 8 (HHV8) has been related to some malignant lymphoproliferations, including post-transplant lymphoproliferative disorders (PTLD). We describe a case of a HHV8 and Epstein-Barr virus (EBV) positive large B-cell lymphoproliferation coexisting with Castleman's disease in the same lymph node of a long-term renal transplant recipient. Biopsy revealed mixed type of Castleman's disease and anaplastic cells showing IgA restriction, although molecular analysis failed to detect monoclonality. Only large cells were co-infected by both EBV and HHV8. After reduction of immunosuppression, the lesion partially regressed. After 1 yr, local evolution required surgery followed by irradiation. The present case represents a unique form of localized monotypic but polyclonal large cell PTLD associated with Castleman's disease. It can be added to PTLD with HHV8 and EBV co-infection.
Theate
Ivan
I
Department of Pathology, Cliniques Universitaires Saint Luc, Université catholique de Louvain, Brussels, Belgium. ivan.theate@clin.ucl.ac.be
Michaux
Lucienne
L
Squifflet
Jean-Paul
JP
Martin
Antoine
A
Raphael
Martine
M
D000328:Adult; D001402:B-Lymphocytes / Q000473:pathology*; D005871:Castleman Disease / Q000150:complications* / Q000473:pathology / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000150:complications* / Q000473:pathology; D006566:Herpesviridae Infections / Q000150:complications* / Q000473:pathology; D019288:Herpesvirus 8, Human; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation; D008198:Lymph Nodes / Q000473:pathology* / Q000821:virology; D008297:Male