Kinetochores, microtubules and the metaphase checkpoint.
A decade ago, kinetochores were generally regarded as rather uninteresting structures that served only to attach mitotic chromosomes to microtubules. In the past few years, however, a number of experiments have belied this view and demonstrated that kinetochores are actively involved in moving chromosomes along the microtubules of the mitotic spindle. Now it appears that in addition to their function in motility, kinetochores act as dynamic and adaptable centres for regulating cell cycle progression through mitosis.
Gorbsky
G J
GJ
Dept of Cell Biology, Box 439, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA.