Muscarinic M2 antagonists: anthranilamide derivatives with exceptional selectivity and in vivo activity.
Anthranilamide analogues such as 23 are potent and highly selective muscarinic M2 antagonists that also show good oral bioavailability and in vivo activity.
Clader
John W
JW
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. john.clader@spcorp.com
Billard
William
W
Binch
Herbert
H
Chen
Lian-Yong
LY
Crosby
Gordon
G
Duffy
Ruth A
RA
Ford
Jennifer
J
Kozlowski
Joseph A
JA
Lachowicz
Jean E
JE
Li
Shengjian
S
Liu
Charles
C
McCombie
Stuart W
SW
Vice
Susan
S
Zhou
Gowei
G
Greenlee
William J
WJ
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001671:Biochemistry / Q000379:methods; D001682:Biological Availability; D016466:CHO Cells; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000379:methods; D018727:Muscarinic Antagonists / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D010880:Piperidines / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D043585:Receptor, Muscarinic M2 / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D062367:ortho-Aminobenzoates / Q000737:chemistry*
C492850:1'-(2-amino-3-methylbenzoyl)-4-(4-((3-chlorophenyl)sulfonyl)phenyl)methyl-1,4'-bipiperidine; D018727:Muscarinic Antagonists; D010880:Piperidines; D043585:Receptor, Muscarinic M2; D062367:ortho-Aminobenzoates; C032727:piperidine; C000219:anthranilamide