[Association between NAD(P)H: quinone oxidoreductase and apolipoprotein E gene polymorphisms in Alzheimer's disease].
OBJECTIVE
To assess the association between NAD(P)H: quinone oxidoreductase 1 (NQO1) C609 T allele and apolipoprotein E (ApoE) polymorphism and sporadic Alzheimer disease (SAD).


METHODS
The polymorphisms of NQO1 and ApoE gene were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 92 SAD patients and 108 normal controls, all of Han nationality.


RESULTS
The frequencies of mutant T allele and T/C + T/T genotype at nucleotide position 609 of NQO1 gene were 56% and 89% respectively in the patients with SAD, significantly higher than those in the controls (45% and 71% respectively) with an odds ratio of 1.56 (for mutant T allele) and of 3.301 (for genotype) respectively. The frequency of the ApoE2 allele was significantly lower in the SAD patients than in the controls (chi(2) = 3.753, P < 0.05) and the frequency of ApoE4 was higher in the SAD patients, however, without a statistically significant difference (chi(2) = 1.863, P = 0.172). No significant interaction was found between NQO1 C609T and ApoE polymorphisms in SAD patients.


CONCLUSIONS
NQO1 C609T may be an independent genetic risk factor for SAD in Chinese.
Ma
Qiu-lan
QL
Department of Neurology, Xuanwu Hospital, Capital University of Medical Science, Beijing 100053, China.
Yang
Jing-fang
JF
Shao
Ming
M
Dong
Xiu-min
XM
Chen
Biao
B
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016660:NAD(P)H Dehydrogenase (Quinone) / Q000235:genetics*; D011110:Polymorphism, Genetic
D001057:Apolipoproteins E; D016660:NAD(P)H Dehydrogenase (Quinone); C447479:NQO1 protein, human