Synthesis of condensed quinolines and quinazolines as DNA ligands.
Among new condensed quinolines and quinazolines the design of which were inspired by anti-cancer DNA-binding alkaloids such as camptothecin and batracyclin, DNA binding tests identify the 8-methoxy-7-piperazinylpropoxyindeno[1,2-b]quinolin-11-one tetracyclic system as a new motif for DNA recognition.
Malecki
Natacha
N
Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille 2, EA 2692, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille, France.
Carato
Pascal
P
Rigo
Benoît
B
Goossens
Jean-François
JF
Houssin
Raymond
R
Bailly
Christian
C
Hénichart
Jean-Pierre
JP
D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D008024:Ligands; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
D008024:Ligands; D011799:Quinazolines; D011804:Quinolines; D004247:DNA