title: Circadian rhythm of blood leptin level in obese and non-obese people.
abstract: Leptin, an adipose tissue hormone, has circadian variations in its secretion. Aims of this study were to show how circadian rhythm depends on fat tissue distribution in obese and non-obese subjects. The research was carried out on 70 subjects (37 men and 33 women) with an average body mass index (BMI) of 25.22 kg/m2. Concentration of leptin in blood was measured at 8.30 a.m., 12.30 p.m. and 6.30 p.m. Basal leptin level correlated strongly with all isolated regions of subcutaneous fat tissue in women and obese subjects. Circadian changes of blood leptin level in non-obese people are more significant than these changes in obese people. Differences in circadian pattern of leptin secretion between obese and non-obese subjects were probably caused by enlarged volume of subcutaneous fat tissue in obese people. Lean subjects have subcutaneous fat in physiological range which allows influence of some hormones (insulin or cortizol) or food intake on leptin secretion.
authors.affiliation: Department of Anatomy, School of Medicine, University J. J. Strossmayer, Osijek, Croatia.
authors.forename: Radivoje
authors.initials: R
authors.lastname: Radić
authors.forename: Vasilije
authors.initials: V
authors.lastname: Nikolić
authors.forename: Ivan
authors.initials: I
authors.lastname: Karner
authors.forename: Pasezada
authors.initials: P
authors.lastname: Kosović
authors.forename: Sven
authors.initials: S
authors.lastname: Kurbel
authors.forename: Robert
authors.initials: R
authors.lastname: Selthofer
authors.forename: Mario
authors.initials: M
authors.lastname: Curković
mesh_terms: D015992:Body Mass Index; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood*; D013851:Thinness / Q000097:blood
chemical_list: D020738:Leptin