title: Elevated P/Q type (alpha1A) and L2 type (alpha1D) Purkinje cell voltage-gated calcium channels in the cerebella of seizure prone gerbils.
abstract: Differences in expression of N-methyl-D-aspartate (NMDA) receptor and voltage gated Ca2+ channels (VGCC) in the gerbil cerebellum were investigated to identify routes of Ca2+ influx that may be involved in Purkinje cell damage. Immunodensities of NR1 and NR2A/B were the same in seizure resistant (SR) and seizure sensitive (SS) gerbils. However, both P/Q type (alpha1A) and L2 type (alpha1D) VGCC levels were higher in the Purkinje cells of SS gerbils than in those of SR gerbils, whereas N type (alpha1B) and L1 type (alpha1C) VGCC levels were similar in the two groups. Our findings suggest that increases in P/Q type (alpha1A) and L2 type (alpha1D) VGCC are implicated in the degeneration of Purkinje cells in SS gerbils.
authors.affiliation: Department of Anatomy, College of Medicine, Hallym University, Chunchon 200-702, Korea.
authors.forename: Seung-Kook
authors.initials: SK
authors.lastname: Park
authors.forename: In Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Sung-Jin
authors.initials: SJ
authors.lastname: An
authors.forename: Moo Ho
authors.initials: MH
authors.lastname: Won
authors.forename: Tae-Cheon
authors.initials: TC
authors.lastname: Kang
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000276:immunology / Q000378:metabolism*; D002531:Cerebellum / Q000276:immunology / Q000378:metabolism*; D005849:Gerbillinae / Q000276:immunology / Q000378:metabolism*; D015151:Immunoblotting; D007150:Immunohistochemistry; D011689:Purkinje Cells / Q000276:immunology / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology
chemical_list: D015220:Calcium Channels; D016194:Receptors, N-Methyl-D-Aspartate