title: Relationship between the ischemic threshold at the onset of wall-motion abnormality on semisupine exercise echocardiography and the extent of coronary artery disease.
abstract: Semisupine exercise echocardiography (SSEE) provides the unique opportunity of continuous monitoring of segmental wall motion during physiologic stress. We evaluated the relationship between the ischemic threshold at the onset of wall-motion abnormality on SSEE and the extent of coronary artery disease (CAD) in a consecutive series of 224 patients who underwent coronary angiography. Ischemic threshold was significantly lower for patients with multivessel disease compared with single-vessel disease: maximal workload was 102 versus 135 W (P = 1.3.10(-6)); percentage of maximal predicted heart rate achieved was 64 versus 70% (P =.004); and double product was 21,335 versus 23,389 (P =.03), respectively. Sensitivity, specificity, and positive and negative predictive values of SSEE for the detection of significant CAD (> or =60% diameter stenosis) were 81%, 74%, 90%, and 56%, respectively. SSEE is an accurate tool to diagnose CAD and the ischemic threshold at the onset of wall-motion abnormality is inversely related to the extent of CAD.
authors.affiliation: Fédération de Cardiologie, Hôpital Henri Mondor, 51 Avenue Delattre de Tassigny, 94010 Créteil, France. elsa.abitbol@hmn.ap-hop-paris.fr
authors.forename: Elsa
authors.initials: E
authors.lastname: Abitbol
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Monin
authors.forename: Jérôme
authors.initials: J
authors.lastname: Garot
authors.forename: Mehrane
authors.initials: M
authors.lastname: Monchi
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Russel
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Duval
authors.forename: Pascal
authors.initials: P
authors.lastname: Gueret
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015308:Anaerobic Threshold / Q000502:physiology*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D025401:Echocardiography, Stress / Q000379:methods; D004562:Electrocardiography; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016683:Supine Position; D016277:Ventricular Function, Left / Q000502:physiology