Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells.
Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin alphaEbeta7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this marker has now helped to unravel a fundamental dichotomy among regulatory T cells. alphaE-CD25+ cells expressed L-selectin and CCR7, enabling recirculation through lymphoid tissues. In contrast, alphaE -positive subsets (CD25+ and CD25-) displayed an effector/memory phenotype expressing high levels of E/P-selectin-binding ligands, multiple adhesion molecules as well as receptors for inflammatory chemokines, allowing efficient migration into inflamed sites. Accordingly, alphaE -expressing cells were found to be the most potent suppressors of inflammatory processes in disease models such as antigen-induced arthritis.
Huehn
Jochen
J
Experimentelle Rheumatologie, Medizinische Klinik, Charité, Humboldt-Universitaet, Schumannstr. 21/22, 10117 Berlin, Germany. Huehn@drfz.de
Siegmund
Kerstin
K
Lehmann
Joachim C U
JC
Siewert
Christiane
C
Haubold
Uta
U
Feuerer
Markus
M
Debes
Gudrun F
GF
Lauber
Joerg
J
Frey
Oliver
O
Przybylski
Grzegorz K
GK
Niesner
Uwe
U
de la Rosa
Maurus
M
Schmidt
Christian A
CA
Bräuer
Rolf
R
Buer
Jan
J
Scheffold
Alexander
A
Hamann
Alf
A
D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D007156:Immunologic Memory / Q000276:immunology*; D016130:Immunophenotyping; D007249:Inflammation / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D020411:Oligonucleotide Array Sequence Analysis; D015375:Receptors, Interleukin-2 / Q000276:immunology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016176:T-Lymphocyte Subsets / Q000276:immunology
D015704:CD4 Antigens; D015375:Receptors, Interleukin-2