[A case of effective weekly paclitaxel administration for primary lesion of schirrous gastric cancer].
We report a case of advanced schirrous gastric cancer with carcinomatous peritonitis. Chemotherapy with TS-1 was applied during the first 4 weeks, but the tumor did not respond to this therapy. Next, paclitaxel (TXL) was administered at a weekly dose of 90 mg/body/day for 3 weeks followed by a week interval of rest. Remarkable mass reduction of primary tumor was observed after 3 courses of treatment, and the symptom derived from primary tumor was relieved without significant side effects. The clinical course for schirrous gastric cancer with carcinomatous peritonitis is still miserable for patients, although many attempts have been made to improve its prognosis. A weekly paclitaxel regimen appears to be one of the promising treatment for schirrous gastric cancer.
Ogasawara
Mitsunari
M
Dept. of Gastroenterology, Kyoto Katsura Hospital.
Kanai
Masashi
M
Tada
Eiji
E
Oe
Keisuke
K
Hamada
Akihiko
A
Endo
Youko
Y
Yamakawa
Masashi
M
Takeda
Yasuhiro
Y
Torii
Ayao
A
Hikita
Hiroshi
H
Matsubayashi
Yuji
Y
Nishikawa
Haruhiro
H
Ochi
Jiro
J
Miura
Kensuke
K
D002293:Adenocarcinoma, Scirrhous / Q000188:drug therapy* / Q000556:secondary; D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage*; D010534:Peritoneal Neoplasms / Q000556:secondary; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel