[Deficiency of glucocorticoid production delays the healing of acute gastric mucosal erosion and chronic ulcers in rats].
Effects of glucocorticoid deficiency followed by corticosterone replacement on the healing of gastric erosions and chronic gastric ulcers have been investigated in rats. Glucocorticoid deficiency was induced by adrenalectomy performed after the formation of gastric erosions or ulcers. Gastric erosions were produced by indomethacin (35 mg/kg, i.p.) or by 6 h immobilization at temperature 8 degrees C, chronic gastric ulcers were induced by 60% acetic acid. All ulcerogenic stimuli caused an increase in corticosterone production. Adrenalectomy created corticosterone deficiency and delayed the healing of gastric erosions and chronic gastric ulcers. The effect of adrenalectomy was more evident in the indomethacin ulcerogenic model. Replacement by corticosterone prompted the healing of gastric erosions and ulcers in adrenalectomized animals. These data suggest a participation of endogenous glucocorticoids in a restoration of gastric mucosal integrity.
Filaretova
L P
LP
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia.
Bagaeva
T R
TR
Podvigina
T T
TT
Morozova
O Iu
OIu
D019342:Acetic Acid; D000315:Adrenalectomy; D000818:Animals; D002908:Chronic Disease; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology; D005753:Gastric Mucosa / Q000473:pathology; D005938:Glucocorticoids / Q000494:pharmacology / Q000502:physiology*; D007103:Immobilization; D007213:Indomethacin; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000628:therapy*; D013696:Temperature; D014945:Wound Healing / Q000502:physiology*
D005938:Glucocorticoids; D019342:Acetic Acid; D003345:Corticosterone; D007213:Indomethacin