title: New diarylheptanoids from the rhizomes of Dioscorea spongiosa and their antiosteoporotic activity.
abstract: Bioassay-guided fractionation of the water extract of the rhizomes of Dioscorea spongiosa led to the isolation and identification of new diarylheptanoids, diospongins A - C, together with three known lignans. Their structures, including absolute stereochemistry, were determined by analyses of NMR data, chemical conversions and CD spectrum. The isolated compounds, except for diospongin A, exerted potent inhibitory activities on bone resorption induced by parathyroid hormone in a bone organ culture system.
authors.affiliation: Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Yin
authors.forename: Kyoji
authors.initials: K
authors.lastname: Kouda
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tezuka
authors.forename: Quan
authors.initials: Q
authors.lastname: Le Tran
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Miyahara
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Chen
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Kadota
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000139:chemically induced / Q000378:metabolism*; D036381:Diarylheptanoids / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D027742:Dioscorea; D051379:Mice; D009924:Organ Culture Techniques; D010024:Osteoporosis / Q000503:physiopathology / Q000517:prevention & control*; D010281:Parathyroid Hormone; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D013237:Stereoisomerism
chemical_list: D036381:Diarylheptanoids; D010281:Parathyroid Hormone; D010936:Plant Extracts