Rapid accumulation of eosinophils in lung lesions in guinea pigs infected with Mycobacterium tuberculosis.
Guinea pig eosinophils were positively identified in bronchoalveolar lavage populations and in the lung granulomas of Mycobacterium tuberculosis-infected guinea pigs. It is possible that the rapid influx of these cells, and their subsequent degranulation during acute pulmonary tuberculosis, may play a key role in the susceptibility of this animal model.
Lasco
Todd M
TM
Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA. Todd.Lasco@colostate.edu
Turner
Oliver C
OC
Cassone
Lynne
L
Sugawara
Isamu
I
Yamada
Hiroyuki
H
McMurray
David N
DN
Orme
Ian M
IM
D000818:Animals; D004198:Disease Susceptibility; D004804:Eosinophils / Q000502:physiology*; D006168:Guinea Pigs; D008168:Lung / Q000473:pathology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000473:pathology*