Isozymes delta of phosphoinositide-specific phospholipase C and their role in signal transduction in the cell.
Phospholipase C (PLC, EC 3.1.4.11) is an enzyme crucial for the phosphoinositol pathway and whose activity is involved in eukaryotic signal transduction as it generates two second messengers: diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). There are four major types of phospholipase C named: beta, gamma, delta and the recently discovered epsilon, but this review will focus only on the recent advances for the delta isozymes of PLC. So far, four delta isozymes (named delta1-4) have been discovered and examined. They differ with regard to cellular distribution, activities, biochemical features and involvement in human ailments.
Ochocka
Anna-Maria
AM
Department of Molecular Medicine, Medical University of Gdańsk, Gdańsk, Poland. ochocka@amg.gda.pl
Pawelczyk
Tadeusz
T
D021581:Active Transport, Cell Nucleus / Q000502:physiology; D000818:Animals; D002417:Cattle; D020536:Enzyme Activators; D004791:Enzyme Inhibitors; D006801:Humans; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D054801:Phosphoinositide Phospholipase C; D054803:Phospholipase C delta; D010727:Phosphoric Diester Hydrolases / Q000235:genetics / Q000378:metabolism*; D021382:Protein Sorting Signals / Q000235:genetics / Q000502:physiology; D051381:Rats; D015398:Signal Transduction / Q000502:physiology*
D020536:Enzyme Activators; D004791:Enzyme Inhibitors; D007527:Isoenzymes; D021382:Protein Sorting Signals; D010727:Phosphoric Diester Hydrolases; D054801:Phosphoinositide Phospholipase C; D054803:Phospholipase C delta