Effect of congestive heart failure on humoral and ex vivo cellular immune responses to influenza vaccination in older adults.
This study examined the effect of congestive heart failure (CHF) on immune responses to influenza vaccination (2000-2001 preparation) in three groups of older adults including healthy, Class II and Class III/IV CHF. Serum antibody titers measured by hemagglutination inhibition (HI), and interferon-gamma (IFN-gamma), interleukin-10 (IL-10) and granzyme B (GrzB) levels in ex vivo virus-activated mononuclear cell cultures showed significant responses from pre-vaccination to 4 and 12 weeks post-vaccination (P<0.01). There was a trend for lower GrzB and higher IFN-gamma and IL-10 levels in healthy versus CHF groups (P<0.06) for all viral strains at 4 weeks. HI titers did not differ between groups. In the regression model, Grz B levels were significantly predicted by the IFN-gamma:IL-10 ratio and performance on the 6 min Walk Test; age and CHF dropped out of the model. In conclusion, CHF in older adults predicts GrzB responses to influenza vaccination due to cytokine and physical ability differences.
McElhaney
Janet E
JE
Center for Immunotherapy of Cancer and Infectious Diseases, MC 1601, University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT 06030-1601, USA. jmcelhaney@uchc.edu
Herre
John M
JM
Lawson
M Louise
ML
Cole
Sharon K
SK
Burke
Bonnie L
BL
Hooton
Jonathan W
JW
D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000032:analysis / Q000096:biosynthesis; D000917:Antibody Formation / Q000276:immunology* / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D053804:Granzymes; D006333:Heart Failure / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology* / Q000502:physiology*; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000276:immunology / Q000517:prevention & control; D007371:Interferon-gamma / Q000096:biosynthesis; D016753:Interleukin-10 / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012697:Serine Endopeptidases / Q000032:analysis / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014611:Vaccination
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D016753:Interleukin-10; D007371:Interferon-gamma; C509213:GZMB protein, human; D053804:Granzymes; D012697:Serine Endopeptidases