title: Development of a quantitative structure-activity relationship model for inhibition of gram-positive bacterial cell growth by biarylamides.
abstract: A set of compounds consisting of a new and diverse collection of biarylamides was examined using quantitative structure-activity relationship techniques for the purpose of developing a model to describe inhibition of gram-positive bacterial growth (minimum inhibition concentration). The model was sought in order to obtain insight for designing new molecules. A detailed analysis of the underlying structure-activity relationship helped provide insight concerning which structural features of the molecules modulated the activity of the compounds against gram-positive organisms.
authors.affiliation: Health Care Research Center, Procter & Gamble Pharmaceuticals, 8700 Mason-Montgomery Road, Mason, Ohio 45040-9462, USA. stanton.dt@pg.com
authors.forename: David T
authors.initials: DT
authors.lastname: Stanton
authors.forename: Prakash J
authors.initials: PJ
authors.lastname: Madhav
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Wilson
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Morris
authors.forename: Paul M
authors.initials: PM
authors.lastname: Hershberger
authors.forename: Christian N
authors.initials: CN
authors.lastname: Parker
mesh_terms: D000577:Amides / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D021281:Quantitative Structure-Activity Relationship
chemical_list: D000577:Amides