Circadian periodicity of plasma lipid peroxides and other anti-oxidants as putative markers in gynecological malignancies.
BACKGROUND
The chronome (from chronos, time, and nomos, rule), or time structure, of lipid peroxidation and anti-oxidant defense mechanisms may relate to prevention and curative chronochemotherapeutic efficacy and management.


METHODS
Newly diagnosed women with gynecological malignancies (N = 30), 30-60 years of age, and age-matched clinically healthy women (N = 35) provided blood samples every 6 hours for 24 hours under standardized conditions. Plasma malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) activities, and serum ascorbate, urate and high-density lipoprotein cholesterol (HDL-C) concentrations were determined.


RESULTS
Each variable underwent circadian variation (p < or = 0.002). Patients differed from controls by their overall chronome-adjusted mean value (MESOR) and by the circadian dynamics in the spectral element of their chronome.


CONCLUSIONS
Chronomes of putative anti- and pro-oxidants should be mapped to explore their putative chemotherapeutic role as markers in cancer chronoprevention and management of established disease.
Singh
Ranjana
R
Departments of Biochemistry, Obstetrics & Gynaecology and Surgery (Surgical Oncology Unit), King George's Medical College, Lucknow-226003, India.
Singh
Rajesh K
RK
Mahdi
A A
AA
Singh
R K
RK
Kumar
A
A
Tripathi
A K
AK
Rai
R
R
Singh
Urmila
U
Cornélissen
G
G
Schwartzkopff
O
O
Halberg
F
F
D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000097:blood*; D002940:Circadian Rhythm; D005260:Female; D005833:Genital Neoplasms, Female / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood*; D008875:Middle Aged
D000975:Antioxidants; D014408:Biomarkers, Tumor; D008054:Lipid Peroxides