title: [Study on the expression of C-erbB-2 gene in coal miners with pneumoconiosis complicated by pulmonary cancer].
abstract: OBJECTIVE
  To study the difference in the expressions of C-erbB-2 gene between the coal miners with pneumoconiosis complicated by pulmonary cancer and the controls with single pulmonary cancer, and its relation to clinical pathology.
  
  
  METHODS
  Measuring the expressions of C-erbB-2 in 32 cases of pneumoconiosis complicated by pulmonary cancer and those in 30 cases of pulmonary cancer by means of immunohistochemistry.
  
  
  RESULTS
  The positive expression rate in 32 cases of pneumoconiosis complicated by pulmonary cancer was 53.13% whereas that in 30 cases of single pulmonary cancer was 26.67% (P < 0.05); the positive expressions of C-erbB-2 in patients with lymph node metastasis (70.59% in pneumoconiosis group, 50.00% in controls) were significantly different from those without lymph node metastasis (33.33% in pneumoconiosis group, 11.11% in controls) (P < 0.05). The prognosis on patients with positive expressions of C-erbB-2 was poor, and was not related to pathologic category.
  
  
  CONCLUSIONS
  C-erbB-2 gene may be an important regulating gene in the coal miners with pneumoconiosis complicated by pulmonary cancer, and as a reference index to determine lymph node metastasis and prognosis.
authors.affiliation: Central Hospital of Mining Group, Zaozhuang, Shandong Province 277011, China.
authors.forename: Jun-hua
authors.initials: JH
authors.lastname: Peng
authors.forename: Chuan-dan
authors.initials: CD
authors.lastname: Zhu
authors.forename: Yong-lai
authors.initials: YL
authors.lastname: Shen
authors.forename: Wen-shou
authors.initials: WS
authors.lastname: Xu
authors.forename: Tai-ke
authors.initials: TK
authors.lastname: Zhang
authors.forename: Hong-mei
authors.initials: HM
authors.lastname: Hou
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
mesh_terms: D000368:Aged; D002681:China; D003032:Coal Mining; D015870:Gene Expression; D018734:Genes, erbB-2; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011009:Pneumoconiosis / Q000150:complications / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism; D016019:Survival Analysis
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases