title: New halimane diterpenoids from Croton oblongifolius.
abstract: Three new halimane-type diterpenoids, crotohalimaneic acid ( 1), crotohalimoneic acid ( 2) and 12-benzoyloxycrotohalimaneic acid ( 3), were isolated from the stem bark of Croton oblongifolius Roxb. Their structures were established on the basis of spectroscopic and X-ray analysis. Compounds 1 and 2 showed non-specific strong cytotoxicity against a panel of human tumor cell lines; whereas 3 was inactive.
authors.affiliation: Research Centre for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Sophon
authors.initials: S
authors.lastname: Roengsumran
authors.forename: Surachai
authors.initials: S
authors.lastname: Pornpakakul
authors.forename: Nongnuj
authors.initials: N
authors.lastname: Muangsin
authors.forename: Polkit
authors.initials: P
authors.lastname: Sangvanich
authors.forename: Thumnoon
authors.initials: T
authors.lastname: Nhujak
authors.forename: Pravit
authors.initials: P
authors.lastname: Singtothong
authors.forename: Narongsak
authors.initials: N
authors.lastname: Chaichit
authors.forename: Songchan
authors.initials: S
authors.lastname: Puthong
authors.forename: Amorn
authors.initials: A
authors.lastname: Petsom
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor / Q000187:drug effects; D029802:Croton; D004224:Diterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts