Enhanced release of platelet factor 4 into the circulation in patients with atopic eczema/dermatitis syndrome.
OBJECTIVE
The active participation of platelet in IgE-mediated inflammatory response is well documented. Platelet factor 4 (PF4), a platelet-specific protein may play an important role in the development of the atopic eczema/dermatitis syndrome (AEDS).


OBJECTIVE
The aim of the study was to evaluate the activation state of circulating platelets in patients suffering from AEDS.


METHODS
In vivo platelet activity was assessed by measuring plasma level of PF4 (enzyme-linked immunoassay method) in 9 males AEDS patients and 11 healthy, nonatopic subjects.


RESULTS
Plasma PF4 was significantly increased (p < 0.05) in AEDS (31.88 +/- 20.48 IU/ml) patients compared with control subjects (2.95 +/- 0.6 IU/ml).


CONCLUSIONS
This result suggests that patients with AEDS may have increased in vivo platelet activation expressed by PF4 release. The aim of the study was to evaluate the activation state of circulating platelets in patients suffering from AEDS.
Kasperska-Zajac
A
A
Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, ul. 3-go Maja 13-15, 41-800 Zabrze, Poland.
Rogala
B
B
Nowakowski
M
M
D000328:Adult; D003876:Dermatitis, Atopic / Q000097:blood / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology; D008297:Male; D015539:Platelet Activation / Q000276:immunology; D010978:Platelet Factor 4 / Q000032:analysis / Q000276:immunology*
D010978:Platelet Factor 4; D007073:Immunoglobulin E