title: Genetic amniocentesis in multiple pregnancy.
abstract: OBJECTIVE
  Second-trimester genetic amniocentesis is the most frequently used invasive prenatal diagnostic technique. Several reports have been published about the effect of genetic amniocentesis on fetal loss in multiple pregnancies over the past two decades. Here we analyze our experience with genetic amniocentesis in multiple pregnancies over the past 10 years.
  
  
  METHODS
  Details of 184 multiple pregnancies were processed in all cases in whom genetic amniocentesis was performed in women who presented at our department since 1990. The outcomes of 175 cases (95.1%) out of 184 genetic amniocenteses were available to us. As a control group, we followed up the outcome of 300 twin pregnancies in which no genetic amniocenteses were performed.
  
  
  RESULTS
  We found that the proportion of spontaneous losses in multiple pregnancies between the 18th and the 24th gestational weeks was 2.39%, whereas if genetic amniocentesis was performed the loss rate before the 24th week was 3.87%. The perinatal mortality rate was 10.03/1,000 in the group who underwent amniocentesis, while it was 10.52/1,000 in the group without amniocentesis.
  
  
  CONCLUSIONS
  Our results suggest that the genetic amniocentesis performed in multiple pregnancies slightly increased (1.48%) the fetal loss rate until the 24th week. Beyond 5 weeks after the procedure, no consequent fetal loss should be expected. In our study the intervention did not have any undesired effect on perinatal mortality rates.
authors.affiliation: 1st Department of Obstetrics and Gynecology, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
authors.forename: Erno
authors.initials: E
authors.lastname: Tóth-Pál
authors.forename: Csaba
authors.initials: C
authors.lastname: Papp
authors.forename: Artúr
authors.initials: A
authors.lastname: Beke
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Bán
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Papp
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology* / Q000235:genetics; D000328:Adult; D000649:Amniocentesis / Q000009:adverse effects / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D005313:Fetal Death / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D007621:Karyotyping / Q000379:methods; D008423:Maternal Age; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D011272:Pregnancy, Multiple / Q000235:genetics / Q000706:statistics & numerical data; D012189:Retrospective Studies; D014310:Triplets / Q000235:genetics / Q000706:statistics & numerical data; D014427:Twins / Q000235:genetics / Q000706:statistics & numerical data