title: CSF lactate dehydrogenase activity in patients with Creutzfeldt-Jakob disease exceeds that in other dementias.
abstract: The diagnosis of Creutzfeldt-Jakob disease (CJD) is still made by exclusion of other dementias. We now evaluated lactate dehydrogenase (LDH) in the cerebrospinal fluid (CSF) as a possible additional diagnostic tool. CSF LDH levels of patients with CJD (n = 26) were compared with those in other dementias (n = 28). LDH isoenzymes were determined in a subset (n = 9). Total LDH and isoenzyme LDH-1 were significantly higher, whereas the fractions of LDH-2 and LDH-3 were significantly lower in CJD patients. We conclude that in addition to established CSF parameters, LDH and its isoenzymes might serve as a further help to discriminate between CJD and other dementias.
authors.affiliation: Department of Neurology, University of Göttingen, Göttingen, Germany. hschmid2@gwdg.de
authors.forename: H
authors.initials: H
authors.lastname: Schmidt
authors.forename: M
authors.initials: M
authors.lastname: Otto
authors.forename: P
authors.initials: P
authors.lastname: Niedmann
authors.forename: L
authors.initials: L
authors.lastname: Cepek
authors.forename: A
authors.initials: A
authors.lastname: Schröter
authors.forename: H A
authors.initials: HA
authors.lastname: Kretzschmar
authors.forename: S
authors.initials: S
authors.lastname: Poser
mesh_terms: D000368:Aged; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid* / Q000201:enzymology*; D003704:Dementia / Q000134:cerebrospinal fluid* / Q000201:enzymology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000134:cerebrospinal fluid; D007770:L-Lactate Dehydrogenase / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase