Fetal bilateral renal agenesis, phocomelia, and single umbilical artery associated with cocaine abuse in early pregnancy.
BACKGROUND
Maternal cocaine abuse in pregnancy is associated with complications such as intrauterine growth retardation, abruptio placentae, and preterm delivery.


METHODS
We report what is, to our knowledge, the first published observation of fetal bilateral renal agenesis associated with a vascular disruption syndrome comprising upper limb reduction defect and a single umbilical artery following maternal cocaine abuse in early pregnancy.


CONCLUSIONS
This constellation in a fetus aborted at 18 weeks extends the spectrum of complications possibly associated with cocaine abuse in pregnancy.
Kashiwagi
Maki
M
Department of Obstetrics & Gynecology, Clinic of Obstetrics & Division of Perinatal, Physiology, University of Zurich, Zurich, Switzerland. Maki.Kashiwagi@fhk.usz.ch
Chaoui
Rabih
R
Stallmach
Thomas
T
Hürlimann
Sandra
S
Lauper
Urs
U
Hebisch
Gundula
G
D000015:Abnormalities, Multiple / Q000139:chemically induced* / Q000175:diagnosis*; D000328:Adult; D003042:Cocaine / Q000633:toxicity*; D019970:Cocaine-Related Disorders; D000013:Congenital Abnormalities; D004480:Ectromelia / Q000139:chemically induced*; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000002:abnormalities*; D008297:Male; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D014469:Umbilical Arteries / Q000002:abnormalities*
D003042:Cocaine