Chitosan salts as nasal sustained delivery systems for peptidic drugs.
The aim of this study was to describe a sustained drug release system based on chitosan salts for vancomycin hydrochloride delivery. Chitosan lactate, chitosan aspartate, chitosan glutamate and chitosan hydrochloride were prepared by spray-drying technique. Vancomycin hydrochloride was used as a model peptidic drug, the nasal sustained release of which should avoid first-pass metabolism in the liver. This in-vitro study evaluated the influence of chitosan salts on the release behaviour of vancomycin hydrochloride from the physical mixtures at pH 5.5 and 7.4. In-vitro release of vancomycin was retarded by chitosan salts and, in particular, chitosan hydrochloride provided the lowest release of vancomycin.
Cerchiara
T
T
Department of Pharmaceutical Sciences, Via S. Donato 19/2, 40127 Bologna, Italy.
Luppi
B
B
Bigucci
F
F
Zecchi
V
V
D000281:Administration, Intranasal; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical; D002686:Chitin / Q000031:analogs & derivatives* / Q000737:chemistry*; D048271:Chitosan; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D017550:Spectroscopy, Fourier Transform Infrared; D014640:Vancomycin / Q000008:administration & dosage*
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D002686:Chitin; D014640:Vancomycin; D048271:Chitosan