title: Immunomodulatory constituents from an Ascomycete, Chaetomium seminudum.
abstract: A screening study focusing on immunomodulatory activity of the EtOAc extract of an Ascomycete, Chaetomium seminudum, has afforded a known epipolythiodioxopiperazine, chetomin (1), together with three new chetomin-related metabolites named chetoseminudins A (2), B (3), and C (4). Among these four metabolites, 1 and 2 have been deduced as the immunosuppressive features of this fungus.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. h-fujimoto@faculty.chiba-u.jp
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Fujimoto
authors.forename: Megumi
authors.initials: M
authors.lastname: Sumino
authors.forename: Emi
authors.initials: E
authors.lastname: Okuyama
authors.forename: Masami
authors.initials: M
authors.lastname: Ishibashi
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002597:Chaetomium / Q000737:chemistry*; D004220:Disulfides; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D026121:Indole Alkaloids; D007564:Japan; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D013154:Spleen / Q000166:cytology
chemical_list: D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D004220:Disulfides; D006576:Heterocyclic Compounds, 4 or More Rings; D026121:Indole Alkaloids; C483272:chetoseminudin A; C483273:chetoseminudin B; C483274:chetoseminudin C; C001598:chetomin