title: Plotting haplotype-specific linkage disequilibrium patterns by extended haplotype homozygosity.
abstract: Association studies may request more details of a specific haplotype. Haplotype-specific decay of linkage disequilibrium is such a crucial and versatile characteristic. It may be used, e.g. to search for signals of natural selection in a risk haplotype. Here, we present a web-based tool to explore the relationship between population frequency and extended linkage disequilibrium measured as haplotype homozygosity of observed haplotypes within a specified candidate region.
  
  
  BACKGROUND
  The web-tool is available at http://ihg.gsf.de/cgi-bin/mueller/webehh.pl
authors.affiliation: Institute of Human Genetics, GSF, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany. jakob.mueller@gsf.de
authors.forename: Jakob C
authors.initials: JC
authors.lastname: Mueller
authors.forename: Christophe
authors.initials: C
authors.lastname: Andreoli
mesh_terms: D000465:Algorithms; D002874:Chromosome Mapping / Q000379:methods*; D003196:Computer Graphics; D020869:Gene Expression Profiling / Q000379:methods*; D006239:Haplotypes; D006720:Homozygote; D020407:Internet; D015810:Linkage Disequilibrium / Q000235:genetics*; D010363:Pattern Recognition, Automated; D017422:Sequence Analysis, DNA / Q000379:methods; D012984:Software; D014584:User-Computer Interface