The regiospecific Fischer indole reaction in choline chloride.2ZnCl2 with product isolation by direct sublimation from the ionic liquid.
The Fischer indole synthesis occurs in high yield with one equivalent of the ionic liquid choline chloride[middle dot]2ZnCl(2); exclusive formation of 2,3-disubstituted indoles is observed in the reaction of alkyl methyl ketones, and the products readily sublime directly from the ionic liquid.
Calderon Morales
Raul
R
The Green Chemistry Research Group, Department of Chemistry, University of Leicester, Leicester, UK.
Tambyrajah
Vasuki
V
Jenkins
Paul R
PR
Davies
David L
DL
Abbott
Andrew P
AP