title: Hard-tissue healing after application of fresh or set MTA as root-end-filling material.
abstract: The purpose of this study was to compare the effect of fresh mineral trioxide aggregate (MTA) with set MTA on hard-tissue healing after periradicular surgery. The root canals of 24 mandibular premolars in four 2-yr-old beagle dogs were filled with MTA. Two weeks later the root ends of half of the samples were surgically exposed and resected to the set MTA within the canals. After exposing and resecting the other 12 root ends, they were prepared with ultrasonic instrumentation and preparations were filled with fresh MTA. After 4 months, the animals were killed. Hard-tissue healing was analyzed histomorphometrically. The results indicated that although freshly placed MTA resulted in a significantly higher incidence of cementum formation (12 of 12 versus 8 of 12, p = 0.028), there is no significant difference in the quantity of cementum or osseous healing associated with freshly placed or set MTA when used as root-end-filling material.
authors.affiliation: Loma Linda University School of Dentistry, CA, USA.
authors.forename: Erol S
authors.initials: ES
authors.lastname: Apaydin
authors.forename: Shahrokh
authors.initials: S
authors.lastname: Shabahang
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Torabinejad
mesh_terms: D017607:Aluminum Compounds / Q000737:chemistry / Q000627:therapeutic use*; D000539:Alveolar Process / Q000187:drug effects / Q000473:pathology; D000818:Animals; D001047:Apicoectomy; D001641:Bicuspid / Q000473:pathology; D015519:Bone Density / Q000187:drug effects; D017610:Calcium Compounds / Q000737:chemistry / Q000627:therapeutic use*; D003739:Dental Cementum / Q000187:drug effects / Q000473:pathology; D004285:Dogs; D004338:Drug Combinations; D007091:Image Processing, Computer-Assisted; D008334:Mandible / Q000187:drug effects / Q000601:surgery; D010087:Oxides / Q000737:chemistry / Q000627:therapeutic use*; D012184:Retrograde Obturation; D012387:Root Canal Filling Materials / Q000737:chemistry / Q000627:therapeutic use*; D018915:Root Canal Preparation / Q000295:instrumentation; D017640:Silicates / Q000737:chemistry / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D013997:Time Factors; D014465:Ultrasonics; D014945:Wound Healing / Q000187:drug effects
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate