title: [A case of pulmonary metastases from laryngeal cancer showing a complete response to chemotherapy with docetaxel].
abstract: Docetaxel (TXT) is a new cytotoxic agent against head and neck, (H and N) cancer since the emergence of cisplatin. We herein describe the efficacy of TXT in treating distant metastases from H and N cancer. The patient was a 61-year-old man who had undergone laryngectomy and irradiation for laryngeal cancer (glottic type: T3N0M0). More than 2 years later after the first course of therapy, pulmonary metastases involved in the left lower area were revealed by lung CT. The divided TXT therapy (20 mg, 3 times, and 40 mg, 3 times) was carried out without any sequelae. This consecutive therapy resulted in complete disappearance of the metastases on follow-up CT. It is suggested that divided TXT therapy has potential as a new treatment modality for distant metastases of H and N cancer.
authors.affiliation: Dept. of Otolaryngology, Toshiba Hospital.
authors.forename: Yoh-ichiro
authors.initials: Y
authors.lastname: Maeda
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Fujishiro
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Chihara
authors.forename: Wakako
authors.initials: W
authors.lastname: Kawanabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukaya
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000556:secondary*; D000077143:Docetaxel; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D043823:Taxoids / Q000008:administration & dosage*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel