title: [Cationic trypsinogen gene mutation in patients with chronic idiopathic pancreatitis].
abstract: OBJECTIVE
  Mutation of Cationic trypsinogen gene is clearly associated with hereditary pancreatitis and plays an important role in the pathogenesis of pancreatitis. According to literature, this mutation is occasionally occurred in patients with pancreatitis in Western countries and Japan. The aim of this study was to find out whether the mutation was observed in Korean patients with chronic idiopathic pancreatitis.
  
  
  METHODS
  Peripheral blood samples of 11 patients with chronic idiopathic pancreatitis were collected consecutively, and DNA was extracted from the samples. Polymerase chain reaction was performed in exon 2 and 3 of cationic trypsinogen gene. Then, DNA products were purified and sequenced.
  
  
  RESULTS
  The mutation was not found in exon 2 and 3 of cationic trypsinogen gene in these patients.
  
  
  CONCLUSIONS
  There was no cationic trypsinogen mutation in Korean patients with chronic idiopathic pancreatitis. Further large sampled cohort study is needed.
authors.affiliation: Center for Liver Cancer, National Cancer Center, Goyang, Korea.
authors.forename: Woo Jin
authors.initials: WJ
authors.lastname: Lee
authors.forename: Kyung-Ah
authors.initials: KA
authors.lastname: Kim
authors.forename: June Sung
authors.initials: JS
authors.lastname: Lee
authors.forename: Young Bin
authors.initials: YB
authors.lastname: Jeon
authors.forename: Ji Bong
authors.initials: JB
authors.lastname: Jeong
authors.forename: Ji Kon
authors.initials: JK
authors.lastname: Ryu
authors.forename: Yong-Tae
authors.initials: YT
authors.lastname: Kim
authors.forename: Yong Bum
authors.initials: YB
authors.lastname: Yoon
authors.forename: Chung Yong
authors.initials: CY
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010195:Pancreatitis / Q000235:genetics*; D016133:Polymerase Chain Reaction; D014357:Trypsin / Q000235:genetics*; D014362:Trypsinogen / Q000235:genetics*
chemical_list: D014362:Trypsinogen; C489303:PRSS1 protein, human; D014357:Trypsin