title: Clinicopathological significance of Borderline Nuclear Change - High Grade Dyskaryosis Not Excluded.
abstract: During a recent discussion on classification of cervical cytology, the introduction of a 'Borderline Nuclear Change - High Grade Dyskaryosis Not Excluded' (BNCH) category was proposed. BNCH cases diagnosed prospectively were retrieved from laboratory records. Questionnaires were sent to referring practitioners regarding clinicopathological outcome. Cytopathological features resulting in the BNCH classification were recorded on slide review. A total of 103 reports on conventional cervical smears diagnosed as BNCH from 1999 to 2002 were retrieved, comprising 0.096% of 107 634 smears. Of 86/103 cases with clinical follow-up, CIN2 or worse was present in 30 (35%); 15 (17%) showed a borderline/low-grade abnormality and 41 (48%) were negative. No individual cytopathological feature was predictive of high-grade disease on follow-up. The yield of high-grade abnormalities on follow-up of BNCH supports the introduction of this terminology.
authors.affiliation: Department of Cytopathology, St Luke's Hospital, Rathgar, Dublin, Ireland. caroline_brodie@vodafone.ie
authors.forename: C
authors.initials: C
authors.lastname: Brodie
authors.forename: R
authors.initials: R
authors.lastname: Kapur
authors.forename: M
authors.initials: M
authors.lastname: Murray
authors.forename: L
authors.initials: L
authors.lastname: Turner
authors.forename: D
authors.initials: D
authors.lastname: Magee
authors.forename: D
authors.initials: D
authors.lastname: Gibbons
mesh_terms: D016477:Artifacts; D002467:Cell Nucleus / Q000473:pathology*; D005260:Female; D006801:Humans; D008403:Mass Screening; D011237:Predictive Value of Tests; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000517:prevention & control; D014626:Vaginal Smears / Q000592:standards*; D002578:Uterine Cervical Dysplasia / Q000473:pathology* / Q000517:prevention & control