title: Evaluation of the fully automated Bactec MGIT 960 system for the susceptibility testing of Mycobacterium tuberculosis to first-line drugs: a multicenter study.
abstract: The accuracy of the Bactec MGIT 960 system for susceptibility testing of 177 clinical isolates of Mycobacterium tuberculosis to first line drugs (isoniazid, rifampicin, ethambutol and streptomycin) was compared with the agar reference method. The sensitivity, the ability to detect resistance, of the MGIT system was 100%, while the specificity, the ability to detect susceptibility, ranged from 98.6% to 100% for all drugs tested.
authors.affiliation: Department of Microbiology, Medical School, University Hospital of Larissa, Papakyriazi 22, Larissa, Greece. anm@otenet.gr
authors.forename: Fanourios
authors.initials: F
authors.lastname: Kontos
authors.forename: Maria
authors.initials: M
authors.lastname: Maniati
authors.forename: Christos
authors.initials: C
authors.lastname: Costopoulos
authors.forename: Zoe
authors.initials: Z
authors.lastname: Gitti
authors.forename: Stavroula
authors.initials: S
authors.lastname: Nicolaou
authors.forename: Efymia
authors.initials: E
authors.lastname: Petinaki
authors.forename: Spyridoula
authors.initials: S
authors.lastname: Anagnostou
authors.forename: Ioannis
authors.initials: I
authors.lastname: Tselentis
authors.forename: Antonios N
authors.initials: AN
authors.lastname: Maniatis
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D004977:Ethambutol / Q000494:pharmacology; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000379:methods*; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D011933:Reagent Kits, Diagnostic; D012293:Rifampin / Q000494:pharmacology; D012680:Sensitivity and Specificity; D013307:Streptomycin / Q000494:pharmacology; D014376:Tuberculosis / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D011933:Reagent Kits, Diagnostic; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin