[Changes of myocardial enzymes in patients with acute carbon monoxide poisoning].
OBJECTIVE
To study the clinical significance of changes of serum myocardial enzymes in patients with acute carbon monoxide poisoning.


METHODS
To determine the dynamic changes of the activity of myocardial enzymes and ECG in 62 patients with acute CO poisoning.


RESULTS
In patients with acute CO poisoning 5 kinds of myocardial enzymes begin to increase within 24 hours, the activities of aspartate aminotransferase (AST), creatine phosphokinase (CPK), lactic dehydrogenase (LDH), alpha-hydroxybutyrate dehydrogenase (alpha-HBDH), CPK isoenzyme (CK-MB) were (20.2 +/- 12.3), (151.6 +/- 91.8), (146.8 +/- 50.4), (154.8 +/- 47.7), (13.8 +/- 8.1) U/L respectively, while those in control group were (12.1 +/- 6.7), (90.6 +/- 17.3), (118.7 +/- 13.5), (89.9 +/- 27.9), (5.9 +/- 3.3) U/L respectively. There was significant difference between two groups (P < 0.01); 3 d later, the activities of 5 enzymes were still increased [(21.3 +/- 12.3), (105.8 +/- 51.4), (144.8 +/- 51.4), (159.8 +/- 35.4), (16.2 +/- 9.1) U/L respectively]. 7 and 12 d later, the activities of alpha-HBDH and CK-MB were still higher than those of control (P < 0.01). LDH(1) and LDH(2) increased to peak value in 24 h after poisoning (35.3 +/- 5.8), (43.8 +/- 5.7) U/L vs (24.8 +/- 3.9), (36.9 +/- 4.3) U/L, P < 0.01. The abnormal rate of serum LDH(1) was 78.7%, LDH(2) 58.3%, LDH 45.2%, CK-MB 37.1%, alpha-HBDH 33.6% and the abnormal rate of ECG was less than 10%.


CONCLUSIONS
Acute carbon monoxide poisoning may cause myocardial injury. Determination of serum myocardial enzymes may contribute to showing myocardial injury, early diagnosis and treatment, results of treatment and prognosis.
Zhang
Jian-guo
JG
Department of Occupation, BaoGang Hospital, BaoTou 014010 China.
Zhang
Hui-ru
HR
Shi
Xue-ying
XY
Zhao
Yan
Y
Su
Yu
Y
Li
Xiu-zhi
XZ
Su
Xiang-ci
XC
Miao
Zhi-ying
ZY
D000328:Adult; D002249:Carbon Monoxide Poisoning / Q000097:blood / Q000201:enzymology*; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D005260:Female; D006801:Humans; D006884:Hydroxybutyrate Dehydrogenase / Q000097:blood; D007527:Isoenzymes / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000201:enzymology*
D007527:Isoenzymes; C035749:2-hydroxybutyrate dehydrogenase; D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form