Oral contraceptive induced chorea: another condition associated with anti-basal ganglia antibodies.
Use of oral contraceptives is a recognised but infrequent cause of chorea. This type of chorea has usually been considered a reactivation of Sydenham's chorea by an unknown mechanism. A patient developed a chorea triggered by the use of oral contraceptives with no definite evidence of previous Sydenham's chorea or recent streptoccocal infections. However, the patient had positive anti-basal ganglia antibodies, which supports an immunological basis for the pathophysiology of this chorea.
Miranda
M
M
Department of Neurology, University of Chile, Chile. marcelomiranda@terra.cl
Cardoso
F
F
Giovannoni
G
G
Church
A
A
D000328:Adult; D000906:Antibodies / Q000276:immunology; D001426:Bacterial Proteins; D001479:Basal Ganglia / Q000276:immunology*; D002819:Chorea / Q000139:chemically induced* / Q000188:drug therapy; D002868:Chromosomal Proteins, Non-Histone; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003851:Deoxyribonucleases / Q000276:immunology; D018492:Dopamine Antagonists / Q000627:therapeutic use; D005149:Facial Expression; D005260:Female; D006801:Humans; D015513:Oncogene Proteins / Q000276:immunology; D000075223:Poly-ADP-Ribose Binding Proteins; D012649:Self Concept; D013301:Streptolysins / Q000276:immunology; D013469:Sulpiride / Q000627:therapeutic use
D000906:Antibodies; D001426:Bacterial Proteins; D002868:Chromosomal Proteins, Non-Histone; D003276:Contraceptives, Oral; C084738:DEK protein, human; D018492:Dopamine Antagonists; D015513:Oncogene Proteins; D000075223:Poly-ADP-Ribose Binding Proteins; D013301:Streptolysins; C025964:streptolysin O; D013469:Sulpiride; D003851:Deoxyribonucleases; C020069:deoxyribonuclease B