The effect of highly active antiretroviral therapy on dermatologic disease in a longitudinal study of HIV type 1-infected women.
The effect of highly active antiretroviral therapy (HAART) on skin diseases was evaluated in 878 human immunodeficiency virus type 1 (HIV-1)-infected women in the Women's Interagency HIV Study, a multicenter prospective study. HIV-1-infected women receiving HAART were less likely to have eczema, folliculitis, tinea pedis, and xerosis than were women who had not initiated HAART, independent of CD4+ cell count. Participants who had a prior history of a nadir CD4+ cell count of <200 cells/microL and recent CD4+ cell counts of 200-349 cells/microL were more likely to have eczema and xerosis than were women with a nadir CD4+ cell count of >200 cells/microL and recent CD4+ cell counts of >349 cells/microL. An HIV-1 RNA load of >100,000 copies/mL was associated with increased prevalence of herpes zoster infection (odds ratio, 6.10; 95% confidence interval, 2.00-18.65). History of injection drug use was associated with a higher prevalence of onychomycosis, tinea pedis, and xerosis. Molluscum contagiosum was more prevalent among younger women.
Maurer
Toby
T
Department of Dermatology, University of California, San Francisco, California, USA. tmaurer@itsa.ucsf.edu
Rodrigues
Lori K E
LK
Ameli
Niloufar
N
Phanuphak
Nittaya
N
Gange
Stephen J
SJ
DeHovitz
Jack
J
French
Audrey L
AL
Glesby
Marshall
M
Jordan
Carol
C
Khalsa
Ann
A
Hessol
Nancy A
NA
D000293:Adolescent; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D003881:Dermatomycoses / Q000150:complications / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D004485:Eczema / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D014009:Onychomycosis / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D014008:Tinea Pedis / Q000453:epidemiology; D016387:Women's Health