title: High plasma ropivacaine concentrations after fascia iliaca compartment block in children.
abstract: BACKGROUND
  The pharmacokinetic profile of local anaesthetics is influenced by the mode of administration. We sought to compare the pharmacokinetics of two doses of ropivacaine after fascia iliaca compartment (FIC) block in children.
  
  
  METHODS
  In this prospective, double-blind study, children received an FIC block as a part of their anaesthetic management during elective orthopaedic surgery on the thigh. They were randomized to receive ropivacaine 0.7 ml x kg(-1) using either a 0.375% or 0.5% solution. Venous blood samples were drawn up to 6 h after injection. Plasma concentrations of ropivacaine were measured by gas-liquid chromatography.
  
  
  RESULTS
  Six children (10.2 (range 5-15) yr, 35.6 (sd 10) kg were included. FIC block provided satisfactory peroperative pain relief. No signs of toxicity were observed, but high maximal plasma concentrations (C(max) 4.33-5.6 microg ml(-1)), were observed for three of four patients in the ropivacaine 0.5% group. The two patients in the 0.375% group showed values within the safe range (C(max) 0.66 and 0.98 microg ml(-1) respectively). Even though no toxic effects were observed, these results led us to discontinue the study.
  
  
  CONCLUSIONS
  The administration of ropivacaine 3.5 mg x kg(-1) can be associated with sustained high plasma concentrations of ropivacaine, outside the tolerable range. In view of these results, we recommend the use of lower ropivacaine dosage during FIC block in children.
authors.affiliation: Department of Paediatric Anaesthesia, Children CHU Timone Hospital, 13385 Marseille Cedex 5, France. olivier.paut@mail.ap-hm.fr
authors.forename: O
authors.initials: O
authors.lastname: Paut
authors.forename: E
authors.initials: E
authors.lastname: Schreiber
authors.forename: F
authors.initials: F
authors.lastname: Lacroix
authors.forename: V
authors.initials: V
authors.lastname: Meyrieux
authors.forename: N
authors.initials: N
authors.lastname: Simon
authors.forename: T
authors.initials: T
authors.lastname: Lavrut
authors.forename: J
authors.initials: J
authors.lastname: Camboulives
authors.forename: B
authors.initials: B
authors.lastname: Bruguerolle
mesh_terms: D000293:Adolescent; D000577:Amides / Q000008:administration & dosage / Q000097:blood*; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006801:Humans; D009407:Nerve Block / Q000379:methods*; D019637:Orthopedic Procedures; D011446:Prospective Studies; D000077212:Ropivacaine; D013848:Thigh / Q000601:surgery
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine