title: Effects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammation.
abstract: The aging process is associated with various morphological and biochemical changes in the nervous system that may affect the processing of noxious inputs. This study showed greater hyperalgesia and up-regulation of spinal dynorphin (DYN) expression in aging than in young adult rats during CFA-induced peripheral inflammation. These data indicate that nociception is regulated differently in aging individuals, a fact that should be considered when selecting treatment strategies for aging populations with persistent pain.
authors.affiliation: Center for Integrative, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, School of Medicine, University of Maryland, Baltimore, MD 21207, USA. Rzhan001@umaryland.edu
authors.forename: Rui-Xin
authors.initials: RX
authors.lastname: Zhang
authors.forename: Lixing
authors.initials: L
authors.lastname: Lao
authors.forename: Jian-Tian
authors.initials: JT
authors.lastname: Qiao
authors.forename: M A
authors.initials: MA
authors.lastname: Ruda
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004399:Dynorphins / Q000235:genetics / Q000378:metabolism*; D005620:Freund's Adjuvant; D007839:Functional Laterality / Q000502:physiology; D006930:Hyperalgesia / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D007150:Immunohistochemistry; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000378:metabolism* / Q000503:physiopathology; D010812:Physical Stimulation; D020671:Posterior Horn Cells / Q000378:metabolism*; D011498:Protein Precursors / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015854:Up-Regulation / Q000502:physiology
chemical_list: D011498:Protein Precursors; D012333:RNA, Messenger; C036448:pre-prodynorphin; D004399:Dynorphins; D005620:Freund's Adjuvant