[Lipoxygenase inhibition and protection of cardiovascular system].
The arachidonic cascade involves three types of metabolic pathways; cyclo-oxygenase, lipoxygenase(LO), and cytochrome P450. The products of LO pathway participate in the pathogenesis of variety of disease such as allergic diseases and hypertension. In particular, 12-hydroxyeicosatetraenoic acid(12-HETE); product of 12-LO pathway, is concerned in the development of hypertension induced by angiotensin-II. In fact, several investigators have reported that 12-HETE has a critical role in hypertension and LO inhibitors have antihypertensive effects in experimental animals. And so, we can expect organ-protective effects of LO inhibitors as well as antihypertensive effects. Besides 12-LO, several investigators mentioned that 5- and 15-LO also have influences to cardiovascular systems. Therefore, we can expect further elucidation of the mechanism of 12-LO's participation in the organ damage and the clinical roles of 12-LO inhibitors to prevent from organ failure in future.
Hisaki
Ryohei
R
Nihon University Surugadai Hospital, Department of Cardiology.
Fujita
Hirotaka
H
Saito
Fumio
F
Kanmatsuse
Katsuo
K
D000818:Animals; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy; D008084:Lipoxygenase / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000627:therapeutic use*; D014468:Umbelliferones
D002317:Cardiovascular Agents; D016859:Lipoxygenase Inhibitors; D014468:Umbelliferones; D008084:Lipoxygenase; C007628:esculetin