title: [Age-dependent reconstruction of element status in Magadan inhabitants].
abstract: On the base of macro- and microelements' concentration in hair of Magadan's inhabitants there were analyzed the changes of aged people's element status. It has been shown that with age, differently directed reconstruction happened, leading to accumulation of one elements and decrease of concentration of others in inhabitants' hair. Elements, undergoing natural age reconstruction, may be considered as indicators and initiators of aging. We have allocated two groups of elements, in dependence on changes' direction. The first group is the main one; Na, K, Ca, Se, As, Mg, Mn, Fe, Zn belong to this group; their level in hair is increasing with age. Taking into account the excretory function of hair, accumulation of named elements is considered as aged removing of these elements out of organism. The exception is the toxic As: its superfluous concentrations in hair reflect the accumulation As in the internal environment of organism. Elements (Cr, Si), concentration of which in hair is decreasing with age, belong to the second group. On the base of literary data, the decreasing of named elements in hair must be interpreted as their programmed decreasing in the organism of aged people. Hence, in aged people there is seen the generalized decreasing of the most studied essential macro- and microelements in the organism. The exception is As, concentration of which is increasing in aged people. The age disorder of element homeostasis may serve as a predictor of "normal" diseases and may be one of pathophysiological mechanisms of aging.
authors.affiliation: International Scientific Center Arktika, Fareastern Branch Russian Academy of Sciences, Magadan, 685000.
authors.forename: E A
authors.initials: EA
authors.lastname: Lugovaia
authors.forename: A L
authors.initials: AL
authors.lastname: Gorbachev
authors.forename: A V
authors.initials: AV
authors.lastname: Efimova
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D001151:Arsenic / Q000032:analysis / Q000378:metabolism; D005260:Female; D006197:Hair / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D012800:Siberia; D014131:Trace Elements / Q000032:analysis / Q000378:metabolism*
chemical_list: D014131:Trace Elements; D001151:Arsenic