Tracking the 'general': tagging skin-derived dendritic cells.
Dendritic cells (DCs) are the sentinels of the immune system; their migration, maturation and mobilization are fundamental to immunity and tolerance. The recent tracking of DCs from the skin to lymph node (LN) and their enumeration using a Cre/loxP system demonstrate the recruitment of a higher than expected number of DCs to the draining LN after cutaneous administration of DNA-coated gold particles. The longevity of the migrated DCs was also longer than previously reported.
Raju
Raghavan
R
Neuromuscular Diseases Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10 Room 4N252, 10 Center Drive, Bethesda, MD 20892, USA. RajuR@ninds.nih.gov
D002465:Cell Movement / Q000502:physiology*; D003713:Dendritic Cells / Q000166:cytology* / Q000502:physiology*; D008198:Lymph Nodes / Q000502:physiology*; D012879:Skin Physiological Phenomena; D013050:Spectrometry, Fluorescence / Q000379:methods; D013194:Staining and Labeling / Q000379:methods