Bordetella bronchiseptica infection in pediatric lung transplant recipients.
Bordetella bronchiseptica are small, pleomorphic Gram-negative coccobacilli which are commensal organisms in the upper respiratory tract of many wild and domestic animals ('kennel cough' in dogs). While it is common for health care providers to ask about exposure to ill family/friends, most do not routinely inquire about the health or immunization status of household pets. We report two cases of B. bronchiseptica pneumonia in lung transplant recipients [cystic fibrosis (CF); ages 10 and 15 yr; one male] who contracted B. bronchiseptica from pet dogs. We compared their course and outcome to four children (two CF, one congenital heart disease and one Duchenne's muscular dystrophy; four males, age range 6 months to 14 yr) with B. bronchiseptica cultured from the respiratory tract. Two of the four patients also acquired their illnesses from pet dogs and two from unknown sources. One lung transplant recipient expired from progressive respiratory failure. We conclude that B. bronchiseptica can cause serious infections in both immunosuppressed and immunocompetent children. We speculate that a detailed history of exposure to ill pets (particularly dogs), and the immunization status of all pets should be included in the routine evaluation of all pediatric transplant recipients.
Ner
Zarah
Z
Division of Pediatric Pulmonology, Department of Pediatrics, Childrens Hospital Los Angeles, Keck-USC School of Medicine, Los Angeles, CA 90027, USA.
Ross
Lawrence A
LA
Horn
Monica V
MV
Keens
Thomas G
TG
MacLaughlin
Eithne F
EF
Starnes
Vaughn A
VA
Woo
Marlyn S
MS
D000293:Adolescent; D000818:Animals; D000829:Animals, Domestic; D001885:Bordetella Infections / Q000150:complications* / Q000662:veterinary; D016950:Bordetella bronchiseptica / Q000302:isolation & purification; D002415:Cats; D002648:Child; D004285:Dogs; D005260:Female; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D011183:Postoperative Complications / Q000209:etiology / Q000382:microbiology; D012189:Retrospective Studies; D016896:Treatment Outcome; D015047:Zoonoses