title: The technique of unilateral double lobar lung transplantation in a canine model.
abstract: OBJECTIVE
  Bilateral living-donor lobar lung transplantation has become an accepted alternative to cadaveric lung transplantation. Because only one lobe is implanted in each chest cavity, this procedure seems to be best suited for children and small adults. The purpose of this study was to develop a technique of unilateral double lobar lung transplantation that can be applied to large adult patients.
  
  
  METHODS
  Unilateral double lobar lung transplantation was performed in 6 weight-matched pairs of dogs. In donor animals the right middle, lower, and cardiac lobes were separated as a right graft, and the left lower lobe was separated as a left graft. In recipient animals these 2 grafts were implanted in the right hemithorax after right pneumonectomy. The left graft was implanted as a right upper lobe, having been rotated 180 degrees along the vertical axis and then 180 degrees along the horizontal axis. The right graft was implanted in the natural anatomic position. Function of the transplanted grafts was assessed for 3 hours after ligation of the left main pulmonary artery while the animals were ventilated with 100% oxygen.
  
  
  RESULTS
  Morphologic adaptation of the 2 grafts in the right hemithorax was found to be excellent. All 6 animals survived the assessment period with excellent pulmonary function. At the end of the 3-hour assessment period, the arterial oxygen tension was 519 +/- 31 mm Hg, and the mean pulmonary artery pressure was 30.5 +/- 1.7 mm Hg.
  
  
  CONCLUSIONS
  Unilateral double lobar lung transplantation was technically possible and associated with satisfactory early pulmonary function in a canine experimental model.
authors.affiliation: Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine and Dentistry, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Okutani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Date
authors.forename: Makio
authors.initials: M
authors.lastname: Hayama
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inokawa
authors.forename: Mikio
authors.initials: M
authors.lastname: Okazaki
authors.forename: Itaru
authors.initials: I
authors.lastname: Nagahiro
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Sano
authors.forename: Motoi
authors.initials: M
authors.lastname: Aoe
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Shimizu
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D004285:Dogs; D016040:Lung Transplantation / Q000379:methods*; D023421:Models, Animal; D008955:Models, Cardiovascular; D010100:Oxygen / Q000097:blood; D011652:Pulmonary Circulation / Q000502:physiology; D011659:Pulmonary Gas Exchange / Q000502:physiology; D016019:Survival Analysis; D035423:Thoracic Cavity / Q000601:surgery; D016896:Treatment Outcome; D012122:Ventilators, Mechanical
chemical_list: D010100:Oxygen