Oxidative coupling of epigallocatechin gallate amplifies antioxidant activity and inhibits xanthine oxidase activity.
Oxidative coupling of epigallocatechin gallate resulted in great improvement in antioxidant activity such as radical scavenging activity against superoxide anion and in activity to inhibit xanthine oxidase, offering high potential as a therapeutic agent for prevention of xanthine oxidase-induced diseases such as gout.
Kurisawa
Motoichi
M
Bio-oriented Technology Research Advancement Institution, and Department of Materials Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
Chung
Joo Eun
JE
Uyama
Hiroshi
H
Kobayashi
Shiro
S
D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010084:Oxidation-Reduction / Q000187:drug effects; D013481:Superoxides / Q000737:chemistry / Q000378:metabolism; D019820:Xanthine / Q000737:chemistry / Q000378:metabolism; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors* / Q000378:metabolism
D000975:Antioxidants; D016166:Free Radical Scavengers; D013481:Superoxides; D019820:Xanthine; D002392:Catechin; C045651:epigallocatechin gallate; D014969:Xanthine Oxidase