title: Surface tailoring of poly(DL-lactic acid) by ligand-tethered amphiphilic polymer for promoting chondrocyte attachment and growth.
abstract: The ligand-tethered poly(ethylene oxide-propylene oxide-ethylene oxide) (PEO-PPO-PEO) triblock copolymer was explored to engineer poly(DL-lactic acid) (PDL-LA) material to promote cell attachment and growth. The PEO-PPO-PEO was activated by methyl sulfonyl chloride and the amino acid, and peptide were attached. By blending the PDL-LA with the ligand-tethered PEO-PPO-PEO derivatives, the surface of modified PDL-LA film was investigated by ATR-FTIR, XPS and contact angle. The chondrocytes test on different PDL-LA films indicated that the PEO-PPO-PEO amino acid and RGD derivatives modified PDL-LA films could promote chondrocyte attachment and growth. This simple surface treatment method may have potentials for tissue engineering and other biomedical applications.
authors.affiliation: Department of Polymer Science and Engineering, Zhejiang University, 310027, Hangzhou, China. jianji@mail.hz.zj.cn
authors.forename: Jian
authors.initials: J
authors.lastname: Ji
authors.forename: Huiguang
authors.initials: H
authors.lastname: Zhu
authors.forename: Jiacong
authors.initials: J
authors.lastname: Shen
mesh_terms: D000327:Adsorption; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D018929:Cell Culture Techniques / Q000379:methods*; D002455:Cell Division / Q000502:physiology; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology* / Q000502:physiology*; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D019344:Lactic Acid / Q000737:chemistry*; D008024:Ligands; D008422:Materials Testing; D009842:Oligopeptides / Q000737:chemistry / Q000378:metabolism*; D011091:Polyesters; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011409:Propylene Glycols / Q000737:chemistry*; D011485:Protein Binding; D011817:Rabbits; D013499:Surface Properties; D013501:Surface-Active Agents / Q000737:chemistry; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D020099:Coated Materials, Biocompatible; D008024:Ligands; D009842:Oligopeptides; C116176:PEO-PPO-PEO; D011091:Polyesters; D011108:Polymers; D011409:Propylene Glycols; D013501:Surface-Active Agents; D019344:Lactic Acid; D011092:Polyethylene Glycols; C033616:poly(lactide); C047981:arginyl-glycyl-aspartic acid