title: Imaging recognition of multidrug resistance in human breast tumors using 99mTc-labeled monocationic agents and a high-resolution stationary SPECT system.
abstract: Imaging recognition of multidrug-resistance by 99mTc-labeled sestamibi, tetrofosmin and furifosmin in mice bearing human breast tumors was evaluated using a high-resolution SPECT, FASTSPECT. Imaging results showed that the washout rates in drug-resistant MCF7/D40 tumors were significantly greater than that in drug-sensitive MCF7/S tumors. Furifosmin exhibited greater washout from both MCF7/S and MCF7/D40 than sestamibi, while tetrofosmin washout was greater than sestamibi in MCF7/D40 only. Feasibility of the monocationic agents for characterizing MDR expression was well clarified with FASTSPECT imaging.
authors.affiliation: Department of Radiology, The University of Arizona, Tucson, AZ 85724 , USA. zliu@radiology.arizona.edu
authors.forename: Zhonglin
authors.initials: Z
authors.lastname: Liu
authors.forename: Gail D
authors.initials: GD
authors.lastname: Stevenson
authors.forename: Harrison H
authors.initials: HH
authors.lastname: Barrett
authors.forename: George A
authors.initials: GA
authors.lastname: Kastis
authors.forename: Michael
authors.initials: M
authors.lastname: Bettan
authors.forename: Lars R
authors.initials: LR
authors.lastname: Furenlid
authors.forename: Donald W
authors.initials: DW
authors.lastname: Wilson
authors.forename: James M
authors.initials: JM
authors.lastname: Woolfenden
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000818:Animals; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002412:Cations; D018432:Drug Resistance, Multiple; D019544:Equipment Failure Analysis; D021621:Imaging, Three-Dimensional / Q000295:instrumentation* / Q000379:methods; D008657:Metabolic Clearance Rate; D051379:Mice; D016513:Mice, SCID; D009928:Organ Specificity; D017556:Technetium Compounds / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation* / Q000379:methods
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D002412:Cations; D017556:Technetium Compounds