Cytotoxic coumarins from Mammea harmandii.
Two new naturally occurring coumarins, isomesuol (1) and mammearin A (2), together with nine known Mammea coumarins 3-11 were isolated from the EtOAc extract of the leaves and twigs of Mammea harmandii. Coumarins 1, 3 and 4 showed cytotoxicity against a panel of mammalian cancer cell lines. Their structures were determined by spectroscopic methods. The assignments of 13C-NMR signals of isomesuol (1), which was isolated for the first time as a natural product, have been revised.
Reutrakul
Vichai
V
Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand. scvrt@mahidol.ac.th
Leewanich
Pornsiri
P
Tuchinda
Patoomratana
P
Pohmakotr
Manat
M
Jaipetch
Thaworn
T
Sophasan
Samaisukh
S
Santisuk
Thawatchai
T
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D031252:Mammea; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves
D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D010936:Plant Extracts