title: Allergic contact dermatitis from a paper mill slimicide containing 2-bromo-4'-hydroxyacetophenone.
abstract: Slimicides are biocidal products used in paper mills to inhibit the proliferation of slime-forming microorganisms that would otherwise spoil the paper products. A laboratory technician working at a paper mill had recurring dermatitis related to contact with the slimicide Busan 1130. We report the first case of allergic contact dermatitis from the slimicide Busan 1130. Diagnostic patch testing was performed with solutions of Busan 1130 and its active ingredient, 2-bromo-4'-hydroxyacetophenone (BHAP). Twenty-five controls were also tested. The patient showed a ++ reaction to 0.1% Busan 1130 aqueous solution and 0.01% BHAP in ethanol. All controls were negative. The patient had recurrent allergic contact dermatitis from exposure to BHAP contained in the slimicide Busan 1130.
authors.affiliation: Department of Dermatology, Odense University Hospital, University of Southern Denmark and National Allergy Research Centre for Consumer Products, Gentofte, Denmark.
authors.forename: Charlotte D
authors.initials: CD
authors.lastname: Jensen
authors.forename: Klaus E
authors.initials: KE
authors.lastname: Andersen
mesh_terms: D000098:Acetophenones / Q000009:adverse effects*; D000485:Allergens / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis* / Q000209:etiology; D009783:Dermatitis, Occupational / Q000175:diagnosis* / Q000209:etiology; D003937:Diagnosis, Differential; D005148:Facial Dermatoses / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010209:Paper; D010328:Patch Tests; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*
chemical_list: D000098:Acetophenones; D000485:Allergens; D011310:Preservatives, Pharmaceutical