title: Global genetic analysis.
abstract: The introduction of molecular markers in genetic analysis has revolutionized medicine. These molecular markers are genetic variations associated with a predisposition to common diseases and individual variations in drug responses. Identification and genotyping a vast number of genetic polymorphisms in large populations are increasingly important for disease gene identification, pharmacogenetics and population-based studies. Among variations being analyzed, single nucleotide polymorphisms seem to be most useful in large-scale genetic analysis. This review discusses approaches for genetic analysis, use of different markers, and emerging technologies for large-scale genetic analysis where millions of genotyping need to be performed.
authors.affiliation: Faculty of Science, Tehran University, Tehran, Iran.
authors.forename: Elahe
authors.initials: E
authors.lastname: Elahi
authors.forename: Jochen
authors.initials: J
authors.lastname: Kumm
authors.forename: Mostafa
authors.initials: M
authors.lastname: Ronaghi
mesh_terms: D000818:Animals; D015415:Biomarkers; D002874:Chromosome Mapping; D030342:Genetic Diseases, Inborn; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005821:Genetic Techniques / Q000639:trends*; D005820:Genetic Testing; D014644:Genetic Variation; D015894:Genome, Human; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
chemical_list: D015415:Biomarkers