Persistent hepatitis associated with chronic active Epstein-Barr virus infection.
A previously healthy boy developed persistent hepatitis without fever or lymphoproliferative disorder. Although serologic tests were not indicative, Epstein-Barr virus (EBV) genome and transcripts were detected from the liver tissue, and real time PCR detected extremely high levels of EBV viremia. EBV infection should be included in the differential diagnoses of hepatitis of unknown etiology, even with unremarkable serologic data.
Yuge
Akihiko
A
Department of Peditrics, Isahaya Hospital, Japan.
Kinoshita
Eiichi
E
Moriuchi
Masako
M
Ohno
Yasuharu
Y
Haga
Hironori
H
Moriuchi
Hiroyuki
H
D001707:Biopsy, Needle; D002675:Child, Preschool; D002908:Chronic Disease; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000175:diagnosis*; D005500:Follow-Up Studies; D006505:Hepatitis / Q000150:complications / Q000188:drug therapy / Q000821:virology*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage; D012367:RNA, Viral / Q000032:analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome
D012367:RNA, Viral; D011239:Prednisolone