[Role of free-radical processes in age-dependent change of energy provision in the liver of rats in stress].
This study was designed to assay the effect of dimethyl sulfoxide to adenine nucleotide and inorganic phosphate concentration in the liver of adult (10-12 month) and old (22-25 month) Wistar male rats during immobilization stress. Investigation have shown that dimethyl sulfoxide injection prevented of AMP concentration decreasing and has no effect to magnitude of ATP decreasing in the both adult and old rats during stress. This antioxidant prevents reduction of total adenine nucleotides level in the liver of old rats during immobilization also. The role of free radical processes stimulation in the adenylate system changes in the liver of adult and old rats during stress have been discussed.
Zakharchenko
I V
IV
Rostov State Medical University, Nakhitchevansky st., 29, Rostov-on-Don, 344022, Russia.
Ovsiannikov
V G
VG
Davydov
V V
VV
D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000375:Aging / Q000378:metabolism*; D000818:Animals; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004734:Energy Metabolism / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology; D005609:Free Radicals / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000378:metabolism*
D016166:Free Radical Scavengers; D005609:Free Radicals; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D004121:Dimethyl Sulfoxide