title: Differences in inhibition of apoptosis depending on the virulence of used herpes simplex virus type 1 strains. Function of interferon alpha in apoptotic death of virus infected cells.
abstract: The purpose of the present study was to determine whether there is the relation between the virulence of used HSV-1 strains and inhibition of apoptosis. HEp-2 cells were induced to apoptosis by osmotic shock after infection by HSV-1 strains. HSV-1 ts, earlier described as less virulent for mice inhibited apoptosis in smaller degree than native strain and HSV-1 tr. We suggest that this is due to the hyperproduction of IFN alpha by human cells after the stimulation by this strain. All strains of HSV-1 didn't inhibit apoptosis in the presence of IFN alpha and apoptosis was inhibited by anti IFN alpha antibodies. We confirm that IFN alpha plays an important function in controlling acute HSV-1 infection.
authors.affiliation: National Institute of Hygiene, Department of Virology, Warsaw, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Rechnio
authors.forename: Bogumiła
authors.initials: B
authors.lastname: Litwińska
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology / Q000502:physiology*; D045744:Cell Line, Tumor; D053938:DNA Fragmentation / Q000276:immunology / Q000502:physiology; D000882:Haplorhini; D006561:Herpes Simplex / Q000276:immunology* / Q000821:virology; D018259:Herpesvirus 1, Human / Q000276:immunology / Q000472:pathogenicity*; D006801:Humans; D016898:Interferon-alpha / Q000276:immunology / Q000502:physiology*; D014774:Virulence; D014779:Virus Replication / Q000276:immunology / Q000502:physiology
chemical_list: D016898:Interferon-alpha