[In vitro antibacterial activity and beta-lactamase stability of meropenem].
The comparative activity of meropenem with that of imipenem, cefotaxime, ceftriaxone and ceftazidime against 856 gram-negative bacilli was studied studied by an agar dilution method. Meropenem and imipenem were high active against tested strains. Resistance to third generation cephalosporins was high for most microorganisms tested. For rapid detection of metallo-beta-lactamase (MBL)-producing gram-negative bacilli a simple disk diffusion test was used. EDTA, FeCl2 and CuCl2 were evaluated as IMP-1 inhibitors. The method is helpful for screening of IMP-1 producers in daily clinical activity.
Poiată
Antonia
A
Facultatea de Farmacie, Disciplina Microbiologie, Universitatea de Medicină şi Farmacie Gr.T. Popa, Iaşi.
Tuchiluş
Cristina
C
Bădicuţ
Ioana
I
Buiuc
D
D
D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D001398:Aztreonam / Q000494:pharmacology; D002439:Cefotaxime / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology; D002443:Ceftriaxone / Q000494:pharmacology; D002954:Citrobacter / Q000187:drug effects; D004338:Drug Combinations; D004755:Enterobacteriaceae / Q000187:drug effects*; D004926:Escherichia coli / Q000187:drug effects; D015378:Imipenem / Q000494:pharmacology; D066298:In Vitro Techniques; D007709:Klebsiella / Q000187:drug effects; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012706:Serratia marcescens / Q000187:drug effects; D013845:Thienamycins / Q000494:pharmacology*; D001618:beta-Lactamases / Q000187:drug effects* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D013845:Thienamycins; D015378:Imipenem; D002443:Ceftriaxone; D002442:Ceftazidime; D001618:beta-Lactamases; D000077731:Meropenem; D001398:Aztreonam; D002439:Cefotaxime