Hydrolytic degradation study of biodegradable polyesteramide copolymers based on epsilon-caprolactone and 11-aminoundecanoic acid.
In this paper, a new kind of aliphatic biodegradable polyesteramide copolymers P(CL/AU)x/y based on epsilon-caprolactone and 11-aminoundecanoic acid were synthesized by the melt polycondensation method. Hydrolytic degradation behavior of P(CL/AU) copolymers were studied by using FTIR, 1H-NMR and DSC. Chemical compositions, macromolecular weight, thickness of the test sample, and pH of the degradation medium have great effect on degradation rate. The degradation rate decreased with increase in aminoundecanoic acid content, macromolecular weight, and thickness of the test samples, but increased with incubation temperature and pH of the degradation medium. The degradation mechanism was studied according to the mathematical model developed by professor Göpferich.
Qian
Zhiyong
Z
Department of Metal Materials, College of Material Science and Engineering, Sichuan University, Chengdu 610065, PR China. dragonqzy@hotmail.com
Li
Sai
S
He
Yi
Y
Zhang
Hailian
H
Liu
Xiaobo
X
D020341:Absorbable Implants; D000577:Amides / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D001673:Biodegradation, Environmental; D002208:Caproates / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007783:Lactones / Q000737:chemistry*; D046911:Macromolecular Substances; D008422:Materials Testing; D008968:Molecular Conformation; D008970:Molecular Weight; D011091:Polyesters / Q000737:chemistry; D013696:Temperature; D014867:Water / Q000737:chemistry
D000577:Amides; D000596:Amino Acids; D001672:Biocompatible Materials; D002208:Caproates; D007783:Lactones; D046911:Macromolecular Substances; D011091:Polyesters; D014867:Water; C121056:caprolactone; C023820:11-aminoundecanoic acid