title: Strontium biokinetics in humans: influence of alginate on the uptake of ingested strontium.
abstract: Radioactive isotopes of strontium, mainly 90Sr, released into the environment due to nuclear accidents may contribute significantly to the internal radiation exposure of members of the public after ingestion of strontium with contaminated foodstuffs. The committed radiation dose is significantly dependent on the fraction of the ingested activity that crossed the gut wall (f1 value). In tracer kinetic investigations, the effect of sodium alginate on the gastrointestinal absorption of strontium was studied in human subjects. Sodium alginate was proven to be a potent agent for reducing strontium absorption with high efficiency and virtually no toxicity. The data obtained show that the uptake of ingested strontium from milk was reduced by a factor of nine when alginate was added to milk. It is concluded that alginate preparations are a suitable antidote against radiostrontium.
authors.affiliation: GSF-National Research Centre for Environment and Health, Institute of Radiation Protection, Ingolstadter Landstrasse 1, D-85764, Neuherberg, Germany. vera.hoellriegl@gsf.de
authors.forename: V
authors.initials: V
authors.lastname: Höllriegl
authors.forename: M
authors.initials: M
authors.lastname: Röhmuss
authors.forename: U
authors.initials: U
authors.lastname: Oeh
authors.forename: P
authors.initials: P
authors.lastname: Roth
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000464:Alginates / Q000008:administration & dosage*; D000818:Animals; D002417:Cattle; D005260:Female; D005507:Food Contamination, Radioactive / Q000032:analysis; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D008892:Milk / Q000737:chemistry*; D011837:Radiation-Protective Agents / Q000008:administration & dosage; D013324:Strontium / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics*
chemical_list: D000464:Alginates; D011837:Radiation-Protective Agents; D013324:Strontium