Moxifloxacin penetration in bronchial secretions of mechanically ventilated patients with pneumonia.
The pharmacokinetics of moxifloxacin was studied in 17 mechanically ventilated patients with pneumonia. Patients were given 400 mg of moxifloxacin intravenously. Blood samples and bronchial secretions were taken on days 1 and 4. A dose of 400 mg of moxifloxacin allows one to achieve efficient concentrations in bronchial secretions and plasma.
Leone
Marc
M
Department of Anesthesiology and Intensive Care Unit and Trauma Center, Nord Hospital, Marseilles, France. leonem@msnotes.wustl.edu
Albanèse
Jacques
J
Sampol-Manos
Emmanuelle
E
Simon
Nicolas
N
Lacarelle
Bruno
B
Bruguerolle
Bernard
B
Martin
Claude
C
D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001372:Aza Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001980:Bronchi / Q000378:metabolism*; D005260:Female; D024841:Fluoroquinolones; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D000077266:Moxifloxacin; D011014:Pneumonia / Q000378:metabolism* / Q000628:therapy; D011804:Quinolines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012121:Respiration, Artificial
D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin