[Effect of polidan on the conditioned memory and structural and metabolic parameters of the rat brain neurons].
New experimental data on the mnemotropic (nootropic) properties of the well-known drug polidan (a DNA derivative) are summarized. The results obtained by histological techniques showed changes in the brain structure, indicating protein synthesis activation under the action of polidan. These results confirm prognostic function of the concept of evolutionary-molecular basis of memory.
Pragina
L L
LL
Laboratory of Memory Mechanism Evolution, Department of Biology, Moscow State University, Vorob'evy gory, Moscow, 119899 Russia.
Tushmalova
N A
NA
Loseva
E V
EV
Kurskaia
O V
OV
Evdokimova
V S
VS
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001921:Brain / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D003213:Conditioning, Psychological / Q000187:drug effects; D004247:DNA / Q000737:chemistry / Q000494:pharmacology*; D005399:Fishes; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009044:Motor Cortex / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D013003:Somatosensory Cortex / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
D004247:DNA