title: Helicobacter pylori persistence: biology and disease.
abstract: Helicobacter pylori are bacteria that have coevolved with humans to be transmitted from person to person and to persistently colonize the stomach. Their population structure is a model for the ecology of the indigenous microbiota. A well-choreographed equilibrium between bacterial effectors and host responses permits microbial persistence and health of the host but confers risk of serious diseases, including peptic ulceration and gastric neoplasia.
authors.affiliation: Department of Medicine, New York University School of Medicine, and New York Harbor Veterans Affairs Medical Center, New York 10016, USA. martin.blaser@med.nyu.edu
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Blaser
authors.forename: John C
authors.initials: JC
authors.lastname: Atherton
mesh_terms: D054439:Ghrelin; D016481:Helicobacter Infections / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D020738:Leptin / Q000378:metabolism; D036361:Peptide Hormones / Q000378:metabolism; D013270:Stomach / Q000382:microbiology*; D013272:Stomach Diseases / Q000382:microbiology* / Q000503:physiopathology; D014774:Virulence
chemical_list: D054439:Ghrelin; D020738:Leptin; D036361:Peptide Hormones