title: [Study on the relationship between smoking, alcohol intake and hyperlipidemia in fishermen].
abstract: OBJECTIVE
  To identify the relationship between smoking, alcohol intake and hyperlipidemia in fishermen.
  
  
  METHODS
  115 fishermen were randomly recruited and divided into case and control groups according to the result of blood lipoprotein. A questionnaire was used to record general information and the history of smoking and alcohol intake. Statistics were gathered to compare the difference of lipoprotein and apolipoprotein level between exposure and control groups and to calculate the OR value of smoking and alcohol intake.
  
  
  RESULTS
  The OR of smoking was 3.417 (95% CI: 1.132 - 10.308), with significant dosage-effect relationship between smoking index and hyperlipidemia. The serum low density lipoprotein-cholesterol (LDL-C) and apolipoprotein (apo) B levels in smoking group was higher than that of control group. The OR value of alcohol intake at early age (early than 20) were 3.275 (95% CI: 1.249 - 8.580) and 4.016 (95% CI: 1.475 - 10.952) respectively. The LDL-C, apoB, the serum total cholesterol (TC)/high density lipoprotein-cholesterol (HDL-C) levels in alcohol abuse group were higher than that of control group.
  
  
  CONCLUSIONS
  Smoking and alcohol abuse were important risk factors of hyperlipidemia, through changing the level of LDL-C and apoB. There was synergistic action between smoking and alcohol abuse in the development of hyperlipidemia.
authors.affiliation: Center for Disease Control and Prevention of Zhoushan City, Zhoushan 316000, China.
authors.forename: Jian-yue
authors.initials: JY
authors.lastname: Wang
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Li-ming
authors.initials: LM
authors.lastname: Shui
authors.forename: Kun
authors.initials: K
authors.lastname: Chen
authors.forename: Sheng-kai
authors.initials: SK
authors.lastname: Yan
authors.forename: Hong
authors.initials: H
authors.lastname: Du
authors.forename: Wu-wei
authors.initials: WW
authors.lastname: Zeng
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.forename: Hong
authors.initials: H
authors.lastname: Xue
authors.forename: Bao-sheng
authors.initials: BS
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005398:Fisheries; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000209:etiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016272:Occupational Health; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D011795:Surveys and Questionnaires
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002784:Cholesterol