Oxyphytosterols are present in plasma of healthy human subjects.
The oxidised derivatives of phytosterols (oxyphytosterols) were identified in plasma samples from thirteen healthy human volunteers, using MS. All the samples contained noticeable quantities of (24R)-5beta,6beta-epoxy-24-ethylcholestan-3beta-ol (beta-epoxysitostanol) and (24R)-ethylcholestan-3beta,5alpha,6beta-triol (sitostanetriol) and also trace levels of (24R)-5alpha,6alpha-epoxy-24-ethylcholestan-3beta-ol (alpha-epoxysitostanol), (24R)-methylcholestan-3beta,5alpha,6beta-triol (campestanetriol) and (24R)-ethylch olest-5-en-3beta-ol-7-one(7-ketositosterol). The amounts of these oxyphytosterols in plasma varied from 4.8 to 57.2 ng/ml. There are two possibilities concerning the origin of these compounds. First, they could come from the small amounts of oxyphytosterols in food. Second, they could originate from the in vivo oxidation of phytosterols in plasma. Very few data actually exist concerning these compounds. Their identification in human samples suggests that further research is necessary in this field.
Grandgirard
André
A
Unité de Nutrition Lipidique, INRA, 17 rue Sully, BP 86510, 21065 DIJON cedex, France. grandgi@dijon.inra.fr
Martine
Lucy
L
Demaison
Luc
L
Cordelet
Catherine
C
Joffre
Corinne
C
Berdeaux
Olivier
O
Semon
Etienne
E
D000328:Adult; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010840:Phytosterols / Q000097:blood*; D012855:Sitosterols / Q000097:blood
C116880:7-ketositosterol; D010840:Phytosterols; D012855:Sitosterols