The genes and proteins of atherogenic lipoprotein production.
Dietary fat provides a major source of nutrition, but may in excess lead to obesity, insulin resistance, high blood cholesterol levels and atherosclerosis. Here we report molecular events that co-ordinate whole-body lipid homoeostasis from insects to humans, viewed in the context of rare and common genetic disorders of apolipoprotein B-containing lipoprotein production.
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Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Du Cane Rd, London W12 0NN, UK. carol.shoulders@csc.mrc.ac.uk
Naoumova
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D000012:Abetalipoproteinemia / Q000235:genetics; D000818:Animals; D001161:Arteriosclerosis / Q000235:genetics* / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics; D006011:Glycogen Storage Disease Type IV / Q000235:genetics; D006801:Humans; D006949:Hyperlipidemias / Q000235:genetics; D008074:Lipoproteins / Q000096:biosynthesis* / Q000378:metabolism
D002352:Carrier Proteins; D008074:Lipoproteins; C030363:lipid transfer protein