First synthesis of an amythiamicin pyridine cluster.
The pyridine-containing central domain of the amythiamicin group of thiopeptide antibiotics is prepared in protected form in 9 steps, 93%ee and 18% overall yield from (S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]thiazole-4-carboxylic acid by Michael addition-cyclodehydration of a 2-(2-thiazolyl)enamine and 1-(2-thiazolyl)propynone.
Bagley
Mark C
MC
School of Chemistry, Cardiff University, PO Box 912, Cardiff, UKCF10 3TB. bagleymc@cf.ac.uk
Dale
James W
JW
Jenkins
Robert L
RL
Bower
Justin
J