Hazard identification and predictability of children's health risk from animal data.
Children differ from adults both physiologically and behaviorally. These differences can affect how and when exposures to xenobiotics occur and the resulting responses. Testing using animal models may be used to predict whether children display novel toxicities not observed in adults or whether children are more or less sensitive to known toxicities. Historically, evaluation of developmental toxicity has focused on gestational exposures and morphological changes resulting from this exposure. Functional consequences of gestational exposure and postnatal exposure have not been as well studied. Difficulties with postnatal toxicity evaluations include divergent differentiation of structure, function and physiology across species, lack of understanding of species differences in functional ontogeny, and lack of common end points and milestones across species.
Morford
LaRonda L
LL
Eli Lilly and Company, Greenfield, Indiana 46140, USA. lmorford@lilly.com
Henck
Judith W
JW
Breslin
William J
WJ
DeSesso
John M
JM
D000818:Animals; D002648:Child; D002657:Child Development; D002669:Child Welfare; D002675:Child, Preschool; D004785:Environmental Pollutants / Q000506:poisoning*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D023421:Models, Animal; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D018570:Risk Assessment
D004785:Environmental Pollutants