title: Penetration of linezolid into the anterior chamber (aqueous humor) of the human eye after intravenous administration.
abstract: We determined the linezolid concentrations in serum samples and aqueous humors (AHs) from 21 patients undergoing cataract extraction. Cataract removal was performed at various times (from 60 to 270 min) after the end of a 30-min infusion of 600 mg of linezolid. Serum samples were obtained 1 h after the end of linezolid administration to determine the maximum concentration of linezolid (C(max)); AHs and a second serum sample were taken simultaneously during the operation, and the concentrations of linezolid in AH (C(AH)) and serum (C(S)) were determined. The mean C(AH) 1 h after linezolid administration was 4.94 micro g/ml, and the mean ratio of C(AH) to C(S) (R = C(AH)/C(S)) was 0.43. All patients had a C(AH) of >2 micro g/ml, which was higher than the MIC at which 90% of Staphylococcus epidermidis strains are inhibited.
authors.affiliation: Institut d'Infeccions i Immunologia, Pfizer Spain, Hospital Clínic, 08036 Barcelona, Spain. egarciav@clinic.ub.es
authors.forename: E García
authors.initials: EG
authors.lastname: Vázquez
authors.forename: J
authors.initials: J
authors.lastname: Mensa
authors.forename: Y
authors.initials: Y
authors.lastname: López
authors.forename: P Díaz
authors.initials: PD
authors.lastname: Couchard
authors.forename: D
authors.initials: D
authors.lastname: Soy
authors.forename: J R
authors.initials: JR
authors.lastname: Fontenla
authors.forename: M
authors.initials: M
authors.lastname: Sarasa
authors.forename: X
authors.initials: X
authors.lastname: Carné
authors.forename: E
authors.initials: E
authors.lastname: Montull
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001082:Aqueous Humor / Q000378:metabolism*; D002387:Cataract Extraction; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D000069349:Linezolid; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D023303:Oxazolidinones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013212:Staphylococcus epidermidis / Q000187:drug effects
chemical_list: D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid