title: Synthesis of 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo-[b,f]furo[2,3-d]oxepin derivatives as potential anxiolytic agents.
abstract: New synthesis approaches that have led to a series of novel tetrahydrodibenzo[b,f]furo[2,3-d]oxepin derivatives are described. According to preliminary data these novel tetracycles can be useful intermediates for the preparation of potential new therapeutic agents.
authors.affiliation: Johnson & Johnson Pharmaceutical Research & Development, a Division of Janssen-Cilag SA, Toledo, Spain. atrabanc@prdes.jnj.com
authors.forename: Andrés Avelino
authors.initials: AA
authors.lastname: Trabanco
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Alonso
authors.forename: José Ignacio
authors.initials: JI
authors.lastname: Andrés
authors.forename: José Maria
authors.initials: JM
authors.lastname: Cid
authors.forename: Javier
authors.initials: J
authors.lastname: Fernández
authors.forename: Laura
authors.initials: L
authors.lastname: Iturrino
authors.forename: Anton
authors.initials: A
authors.lastname: Megens
mesh_terms: D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010082:Oxepins / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D014151:Anti-Anxiety Agents; D007202:Indicators and Reagents; D010082:Oxepins