Weight loss-induced calciphylaxis: potential role of matrix metalloproteinases.
Calciphylaxis is an uncommon and often devastating syndrome of calcification of small vessels, leading to tissue infarction. The mechanism of how calcium deposits on small vessels is unknown. Recently, metalloproteinase digestion of elastin has been shown to enhance deposition of calcium, suggesting a possible mechanism of calciphylaxis. We describe a case of a patient who developed calciphylaxis after rapid weight loss, but had normocalcemia and normal renal function. She was found to have high levels of matrix metalloproteinases, which may have chemically altered elastin, allowing deposition of calcium on small vessels. Inhibitors of matrix metalloproteinases may be useful in the prevention and treatment of calciphylaxis.
Munavalli
Girish
G
Department of Dermatology, Emory University School of Medicine, Atlanta, GA, U.S.A.
Reisenauer
Amy
A
Moses
Marsha
M
Kilroy
Susan
S
Arbiser
Jack L
JL
D000328:Adult; D002115:Calciphylaxis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000209:etiology*; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D009765:Obesity; D015431:Weight Loss
D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases