[Immunosuppressive effects of a new phenothiazine derivative].
An original phenothiazine, CPTZ, was tested for its effects on the mouse immune system. Serum opsonic capacity, phagocyte and bactericidal activity of peritoneal macrophages, counts of splenic cells forming hemolysis plaques, and the number of survivors after experimental infection were recorded. The effects observed were compared with those produced by levamisole (a non-selective immunomodulator) and indometacin (an antiinflammatory drug with selective immunomodulator properties). The effects of CPTZ might be useful for the development of a new class of immunosuppressor drugs.
Ghiciuc
C M
CM
Département de Pharmacologie-Toxicologie-Algologie, Faculté de Médecine, Université de Médecine et de Pharmacie Gr. T. Popa, Iai, Roumanie.
Samson-Belei
D
D
Lupuşoru
C E
CE
Bâcu
E
E
Antonesi
I M
IM
Jerca
O
O
Lupuşoru
R
R
Couture
A
A
Grandclaudon
P
P
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D005260:Female; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D007978:Levamisole / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D009895:Opsonin Proteins / Q000097:blood; D010587:Phagocytosis / Q000187:drug effects; D010640:Phenothiazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000276:Adjuvants, Immunologic; D007166:Immunosuppressive Agents; D009895:Opsonin Proteins; D010640:Phenothiazines; D007978:Levamisole; D007213:Indomethacin