title: A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam.
abstract: The deposition of tau inclusions is one of the neuropathological hallmarks in neurodegenerative disorders with dementia. We have reported that the N-terminal fragment of a human granin-like neuroendocrine peptide precursor (N-proSAAS) is accumulated in Pick bodies. However, it is unknown whether N-proSAAS is widely accumulated in tau inclusions in other tauopathies. Here, we performed an immunohistochemical examination using antibodies against both the N- and C-terminal sequence of proSAAS in the brains of patients with Alzheimer's disease and parkinsonism-dementia complex on Guam. The antibody against N-proSAAS immunostained neurofibrillary tangles and neuritic plaques in both diseases, whereas the antibody against the C-terminal sequence of proSAAS did not. The results of the present study suggest that N-proSAAS or proSAAS-like molecules were trapped within the tau fibrils and accumulated in tau inclusions.
authors.affiliation: Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata 990-9585, Japan. mwada@yacht.ocn.ne.jp
authors.forename: Manabu
authors.initials: M
authors.lastname: Wada
authors.forename: Chang-Hong
authors.initials: CH
authors.lastname: Ren
authors.forename: Shingo
authors.initials: S
authors.lastname: Koyama
authors.forename: Shigeki
authors.initials: S
authors.lastname: Arawaka
authors.forename: Shinobu
authors.initials: S
authors.lastname: Kawakatsu
authors.forename: Hideki
authors.initials: H
authors.lastname: Kimura
authors.forename: Hikaru
authors.initials: H
authors.lastname: Nagasawa
authors.forename: Toru
authors.initials: T
authors.lastname: Kawanami
authors.forename: Keiji
authors.initials: K
authors.lastname: Kurita
authors.forename: Makoto
authors.initials: M
authors.lastname: Daimon
authors.forename: Asao
authors.initials: A
authors.lastname: Hirano
authors.forename: Takeo
authors.initials: T
authors.lastname: Kato
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D003704:Dementia / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006141:Guam; D006624:Hippocampus / Q000737:chemistry / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000032:analysis*; D020734:Parkinsonian Disorders / Q000378:metabolism* / Q000473:pathology; D010446:Peptide Fragments / Q000378:metabolism; D011498:Protein Precursors / Q000032:analysis*; D051381:Rats; D016875:tau Proteins / Q000032:analysis*
chemical_list: D009479:Neuropeptides; C403532:PCSK1N protein, human; D010446:Peptide Fragments; D011498:Protein Precursors; D016875:tau Proteins