Synthesis and antifungal activities of phenylenedithioureas.
A total of 20 new phenylenedithiourea derivatives was synthesized by reaction of phenylenediisothiocyanates with aromatic amines as aminobenzoic, aminosalicylic acid and their derivatives. Their chemical structures were confirmed by elemental analysis, IR spectrometry and 1H NMR. The compounds were screened for in vitro antifungal, antibacterial activities and some of them have strong antifungal activities comparable to the activity observed for ketoconazole.
Phuong
Truong
T
Pharmaceutical Chemistry Department, Faculty of Pharmacy, HoChiMinh City Medicine and Pharmacy University, 41-43 DinhTienHoang Street, 1st District, HoChiMinh City, Viet Nam. phuongnq@hcm.ftp.vn
Khac-Minh
Thai
T
Van Ha
Nguyen Thi
NT
Ngoc Phuong
Huynh Thi
HT
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D007654:Ketoconazole / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001555:Benzene Derivatives; D013890:Thiourea; D007654:Ketoconazole