Improved model of multicomponent adsorption in reversed-phase liquid chromatography.
This work presents a modification to the real adsorbed solution model using a Flory-Huggins type of expression that was reported previously. This modification consists in replacing the Flory-Huggins activity coefficient by the spreading pressure dependent approach. This new model takes into account explicitly the adsorbate-adsorbate interactions taking place in the adsorbed phase. It provides an excellent prediction of the competitive, ternary adsorption equilibrium of benzyl alcohol, 2-phenylethanol and 2-methyl benzyl alcohol observed in a reversed-phase liquid chromatographic system using information merely derived from the single-component adsorption experimental data.
Garcia-Galdo
Jorge E
JE
Departamento de Desarrollo Tecnológico, Centro de Química Farmacéutica (CQF), Calle 200 y 21, Apdo. 16042, Atabey, Playa, La Habana, Cuba.
Cobas-Rodriguez
José
J
Jáuregui-Haza
Ulises J
UJ
Guiochon
Georges
G
D000327:Adsorption; D002853:Chromatography, Liquid / Q000379:methods*