[Combined use of an antihypoxic agent and a B-cell stimulator].
Evaluation of the effect of poviargol on the B cells of mice showed that the drug activity is retained for 21 h upon single injection. An analysis of the refractory period between the B-cell stimulant introduction and the administration of various antihypoxants showed that the most effective treatment is provided by poviargol injection 14 days before and antihypoxant (IEM-1875 preparation) 30 min before the hypoxia model induction. This regime, ensuring the best protection of experimental animals from hypoxia, can be of great importance and value in the prophylaxis of hypoxia in various pathological conditions.
Nezhinskaia
G I
GI
Laboratory of General Immunology, Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, ul. akademika Pavlova 12, St. Petersburg, 197376 Russia.
Nazarov
P G
PG
Petrova
N N
NN
Sapronov
N S
NS
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D004359:Drug Therapy, Combination; D000860:Hypoxia / Q000276:immunology / Q000517:prevention & control*; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D018030:Silver Compounds / Q000494:pharmacology* / Q000627:therapeutic use
D018030:Silver Compounds; C081379:poviargol