Surface-attached molecular beacons light the way for DNA sequencing.
Rapid testing of DNA and RNA nucleotide sequences is required for various research protocols including wide-scale genetic testing, diagnostics, fast detection of biological warfare agents, environmental testing and forensic medicine. At present many laboratories are interested in research and development of an inexpensive, easy-to-use, fast-response device for this purpose. Various methods based on acoustic, electronic and optical detection of the DNA hybridization event have been reported.
Palecek
Emil
E
Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 612 65, Brno, Czech Republic. palecek@ibp.cz
D000162:Acoustics; D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000032:analysis* / Q000737:chemistry*; D015342:DNA Probes; D004563:Electrochemistry / Q000379:methods*; D005456:Fluorescent Dyes; D055095:Optics and Photonics; D017422:Sequence Analysis, DNA / Q000379:methods*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013194:Staining and Labeling / Q000379:methods
D015342:DNA Probes; D005456:Fluorescent Dyes; D004247:DNA