Methamphetamine and AIDS: 1HMRS studies in a feline model of human disease.
Potential interactions between psychostimulant drugs and infection with feline immunodeficiency virus (FIV) on brain metabolism were evaluated. Four groups of cats were studied: control, FIV positive, methamphetamine (MA) exposed, and FIV positive plus MA exposed. Frontal gray matter, frontal white matter, and caudate brain extracts were studied with proton magnetic resonance spectroscopy (1HMRS). In the frontal white matter, FIV-infected cats showed decreases in creatine and choline, while MA-treated cats had elevated gamma-aminobutyric acid (GABA). The decreased glutamate in FIV cats normalized with MA exposure. FIV and MA both affect brain metabolites individually and combined. 1HMRS is useful for evaluating the effects of FIV and drug abuse in the brain.
Cloak
C C
CC
Medical Department, Brookhaven National Laboratory, Buliding 490, Upton, NY, USA. cloak@bnl.gov
Chang
L
L
Ernst
T
T
Barr
M C
MC
Huitron-Resendiz
S
S
Sanchez-Alavez
M
M
Phillips
T R
TR
Henriksen
S
S
D000163:Acquired Immunodeficiency Syndrome / Q000378:metabolism / Q000821:virology; D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism / Q000821:virology*; D001923:Brain Chemistry; D002415:Cats; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D004195:Disease Models, Animal; D016089:Immunodeficiency Virus, Feline; D007239:Infections; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008694:Methamphetamine / Q000494:pharmacology*; D011897:Random Allocation; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D008694:Methamphetamine; D005680:gamma-Aminobutyric Acid; D003401:Creatine; D002794:Choline