Screening-detected breast cancer in a man with BRCA2 mutation: case report.
Current indications for breast cancer screening in the male population are lacking, although family history of breast cancer may be such an indication. The authors describe a man with a history of clinically diagnosed right breast cancer who subsequently tested positive for the breast cancer susceptibility gene BRCA2 and received a diagnosis of mammographically detected left breast cancer at screening. The authors discuss the clinical implications of this approach to detecting male breast cancer.
Brenner
R James
RJ
Eisenberg Keefer Breast Center, John Wayne Cancer Institute, Saint Johns Health Center, 1328 22nd St, Santa Monica, CA 90404, USA. james.brenner@stjohns.org
Weitzel
Jeffrey N
JN
Hansen
Nora
N
Boasberg
Peter
P
D000368:Aged; D024682:BRCA2 Protein / Q000235:genetics*; D001707:Biopsy, Needle; D001940:Breast / Q000473:pathology; D018567:Breast Neoplasms, Male / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D005500:Follow-Up Studies; D018095:Germ-Line Mutation; D006801:Humans; D008297:Male; D008403:Mass Screening; D008408:Mastectomy; D009367:Neoplasm Staging; D009376:Neoplasms, Hormone-Dependent / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology / Q000628:therapy; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D011859:Radiography; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012086:Reoperation; D021701:Sentinel Lymph Node Biopsy
D024682:BRCA2 Protein; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone