[A case of sarcomatoid combined hepatocellular-cholangiocarcinoma].
Combined hepatocellular-cholangiocarcinoma (HCC-CC) with sarcomatoid features is an extremely rare primary liver cancer, of which only four cases have been reported. We report a case of sarcomatoid combined HCC-CC in a 60-year-old woman who complained of right upper quadrant pain and presented with a 7 cm mass in the S4 region of the liver in abdominal CT. Ultrasonography-guided needle biopsy diagnosed it as HCC, and left lobectomy of the liver followed. Microscopically, the tumor consisted of two portions: HCC portion showing trabecular pattern, which had partially sarcomatous area with spindle-shaped tumor cells, and CC portion with glandular pattern. Immunohistochemically, HCC portion reacted positively with alpha-fetoprotein while CC portion demonstrated positive reactivity with carcinoembryonic antigen and mucicarmine. Sarcomatoid cells reacted positively for cytokeratin. She died of tumor recurrence and hepatic failure 12 months after the operation. Combined HCC-CC has poor prognosis, and sarcomatoid HCC has high metastatic potential and poor prognosis compared with ordinary HCC.
Jeong
Bong Ju
BJ
Department of Internal Medicine, Inha University College of Medicine, Incheon, Korea.
Hyun
Dong Hyo
DH
Lee
Kyoung Wook
KW
Ryu
Sung Tae
ST
Lee
Jin-Woo
JW
Lee
Jung Il
JI
Jeong
Seok
S
Lee
Don Hang
DH
Kim
Pum-Soo
PS
Kim
Hyung Gil
HG
Kim
Young Soo
YS
Kim
Jun Mee
JM
D001650:Bile Duct Neoplasms / Q000473:pathology*; D017734:Bile Ducts, Extrahepatic; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008875:Middle Aged; D012509:Sarcoma / Q000473:pathology*