Off-pump mitral valve repair using the Coapsys device: a pilot study in a pacing-induced mitral regurgitation model.
OBJECTIVE
The purpose of this study was to evaluate the ability of the Myocor Coapsys device to restore leaflet apposition and valve competency off-pump in a canine model of functional mitral regurgitation (MR).


METHODS
The Coapsys device was surgically implanted in 10 dogs after MR induction by rapid ventricular pacing. The Coapsys consists of anterior and posterior epicardial pads connected by a subvalvular chord. The annular head of the posterior pad was positioned at the annular level to draw the posterior leaflet and annulus toward the anterior leaflet. Final device size was selected when MR was minimized or eliminated as assessed by color flow Doppler echocardiography.


RESULTS
All implants were placed off-pump without atriotomy, and mean MR grade was reduced from 2.9 +/- 0.7 to 0.6 +/- 0.7 (p < 0.001) acutely. No hemodynamic compromise was noted.


CONCLUSIONS
The Coapsys device consistently and significantly reduced or eliminated functional MR acutely. Further study will be required to assess the chronic stability of the repair in this animal model.
Fukamachi
Kiyotaka
K
Department of Biomedical Engineering, Lerner Research Institute, Cleveland, Ohio, USA. fukamach@bme.ri.ccf.org
Inoue
Masahiro
M
Popović
Zoran B
ZB
Doi
Kazuyoshi
K
Schenk
Soren
S
Nemeh
Hassan
H
Ootaki
Yoshio
Y
Kopcak
Michael W
MW
Dessoffy
Raymond
R
Thomas
James D
JD
Bianco
Richard W
RW
Berry
James M
JM
McCarthy
Patrick M
PM
D000818:Animals; D002304:Cardiac Pacing, Artificial; D002315:Cardiopulmonary Bypass; D020099:Coated Materials, Biocompatible; D004195:Disease Models, Animal; D004285:Dogs; D018618:Echocardiography, Doppler, Color; D005240:Feasibility Studies; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000601:surgery; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000601:surgery; D006439:Hemodynamics; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000000981:diagnostic imaging / Q000601:surgery*; D011091:Polyesters; D011138:Polytetrafluoroethylene; D019736:Prostheses and Implants
D020099:Coated Materials, Biocompatible; D011091:Polyesters; D011138:Polytetrafluoroethylene