Anti-viral cyclam macrocycles : rapid zinc uptake at physiological pH.
NMR and UV-vis spectroscopic studies show that Zn(II) binds to cyclam rapidly at micromolar concentrations, an observation relevant to the anti-viral activity and co-receptor binding of anti-HIV cyclams.
Paisey
Stephen J
SJ
School of Chemistry, University of Edinburgh, West Mains Road, Edinburgh EH9 3JJ, Scotland, UK.
Sadler
Peter J
PJ
D019380:Anti-HIV Agents / Q000737:chemistry / Q000378:metabolism*; D003300:Copper / Q000378:metabolism; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013053:Spectrophotometry; D013997:Time Factors; D015032:Zinc / Q000378:metabolism*
D019380:Anti-HIV Agents; D006571:Heterocyclic Compounds; C024560:cyclam; D003300:Copper; D015032:Zinc