tPA and proteolysis in the neurovascular unit.
Lo
Eng H
EH
Neuroprotection Research Laboratory, Department of Radiology, Massachusetts General Hospital, and Program in Neuroscience, Harvard Medical School, Charlestown 02129, USA. Lo@helix.mgh.harvard.edu
Broderick
Joseph P
JP
Moskowitz
Michael A
MA
D000818:Animals; D001253:Astrocytes / Q000187:drug effects* / Q000201:enzymology; D002543:Cerebral Hemorrhage / Q000139:chemically induced / Q000517:prevention & control; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D020782:Matrix Metalloproteinases / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology; D010447:Peptide Hydrolases / Q000187:drug effects / Q000378:metabolism*; D020521:Stroke / Q000188:drug therapy* / Q000503:physiopathology; D010959:Tissue Plasminogen Activator / Q000009:adverse effects / Q000627:therapeutic use*; D015854:Up-Regulation / Q000187:drug effects
D004791:Enzyme Inhibitors; D010447:Peptide Hydrolases; D010959:Tissue Plasminogen Activator; D020782:Matrix Metalloproteinases