title: Aggressive squamous cell carcinoma originating as a Marjolin's ulcer.
abstract: BACKGROUND
  Marjolin's ulcer is an epidermoid carcinoma arising in a scar or chronic wound and can have an aggressive course.
  
  
  OBJECTIVE
  To present a case of squamous cell carcinoma arising in a burn scar with resulting metastases and to discuss Marjolin's ulcer.
  
  
  RESULTS
  The patient continued to have further metastatic disease despite aggressive surgical treatment.
  
  
  CONCLUSIONS
  In following patients with chronic ulcers and wounds, it is important to evaluate any changes immediately with biopsies and further imaging studies if indicated in order to treat effectively. Even aggressive surgical intervention will sometimes be inadequate in treating these tumors.
authors.affiliation: Dermatology and Skin Cancer Specialists, Kansas City, Missouri, USA.
authors.forename: Shawn R
authors.initials: SR
authors.lastname: Sabin
authors.forename: Glenn
authors.initials: G
authors.lastname: Goldstein
authors.forename: Howard G
authors.initials: HG
authors.lastname: Rosenthal
authors.forename: Kimberly K
authors.initials: KK
authors.lastname: Haynes
mesh_terms: D000368:Aged; D002056:Burns / Q000150:complications* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology* / Q000601:surgery; D002921:Cicatrix / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D017169:Neoplasms, Post-Traumatic / Q000209:etiology* / Q000473:pathology* / Q000601:surgery