Why rest stimulates bone formation: a hypothesis based on complex adaptive phenomenon.
Moderate exercise is an ineffective strategy to build bone mass. The authors present data demonstrating that allowing bone to rest between each load cycle transforms low- and moderate-magnitude mechanical loading into a signal that potently induces bone accretion. They hypothesize that the osteogenic nature of rest-inserted loading arises by enabling osteocytes to communicate as a small world network.
Gross
Ted S
TS
Orthopaedic Science Laboratories, Department of Orthopaedics and Sports Medicine, University of Washington, Seattle 98107, USA. tgross@u.washington.edu
Poliachik
Sandra L
SL
Ausk
Brandon J
BJ
Sanford
David A
DA
Becker
Blair A
BA
Srinivasan
Sundar
S
D000222:Adaptation, Physiological; D015444:Exercise / Q000502:physiology*; D006801:Humans; D009142:Musculoskeletal Physiological Phenomena; D010011:Osteocytes / Q000378:metabolism / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology*; D012146:Rest / Q000502:physiology*; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D016474:Weight-Bearing