title: The relationship between infant airway function, childhood airway responsiveness, and asthma.
abstract: The relationship between reduced pulmonary function in early life and persistent wheeze (PW) in school-aged children remains uncertain. In this study, VmaxFRC was assessed at 1 month of age, and the presence of wheeze up to 11 years of age was prospectively identified. At 11 years of age, airway responsiveness (AR) to inhaled histamine and atopy were assessed. Recent wheeze at 11 years of age was associated with a reduced mean z score for VmaxFRC at 1 month of age (-0.41 [SD 0.91], n = 31) compared with no recent wheeze (0.04 [SD 1.00], n = 153, p = 0.03). Wheeze between 4 and 6 years that persisted at 11 years (PW) was most prevalent among those with reduced VmaxFRC at 1 month and atopy aged 11 years (p = 0.002) or reduced VmaxFRC and increased AR aged 11 years (p = 0.015). When all factors were considered, reduced VmaxFRC at 1 month (p = 0.03) and increased AR aged 11 years (p < 0.001) were independently associated with PW (n = 17) compared with other outcomes (n = 129). Reduced airway function present in early infancy is associated with PW at 11 years of age, and this relationship is independent of the effect of increased AR and atopy in childhood.
authors.affiliation: School of Paediatrics and Child Health, University of Western Australia, and Department of Respiratory Medicine, Princess Margaret Hospital for Children, Perth, Australia. s.w.turner@abdn.ac.uk
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Turner
authors.forename: Lyle J
authors.initials: LJ
authors.lastname: Palmer
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Rye
authors.forename: Neil A
authors.initials: NA
authors.lastname: Gibson
authors.forename: Parveenjeet K
authors.initials: PK
authors.lastname: Judge
authors.forename: Moreen
authors.initials: M
authors.lastname: Cox
authors.forename: Sally
authors.initials: S
authors.lastname: Young
authors.forename: Jack
authors.initials: J
authors.lastname: Goldblatt
authors.forename: Louis I
authors.initials: LI
authors.lastname: Landau
authors.forename: Peter N
authors.initials: PN
authors.lastname: Le Souëf
mesh_terms: D001249:Asthma / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D005652:Functional Residual Capacity; D006801:Humans; D007223:Infant; D008168:Lung / Q000503:physiopathology*; D008297:Male; D011379:Prognosis; D012135:Respiratory Sounds / Q000209:etiology* / Q000503:physiopathology; D012307:Risk Factors