title: Comparison of the dynamics of resistance-associated mutations to nucleoside reverse transcriptase inhibitors, nonnucleoside reverse transcriptase inhibitors, and protease inhibitors after cessation of antiretroviral combination therapy.
abstract: The dynamics of mutations associated with resistance to antiretroviral drugs were analyzed after cessation of therapy. The results showed that the kinetics of the shift to wild-type amino acid residues were significantly faster for protease inhibitors, intermediate for nonnucleoside reverse transcriptase inhibitors, and slower for nucleoside reverse transcriptase inhibitors.
authors.affiliation: Department of Virology, INSERM EMI 0214, Pitié-Salpêtrière Hospital, Paris, France. marc.wirden@psl.ap-hop-paris.fr
authors.forename: Marc
authors.initials: M
authors.lastname: Wirden
authors.forename: Constance
authors.initials: C
authors.lastname: Delaugerre
authors.forename: Anne Genevieve
authors.initials: AG
authors.lastname: Marcelin
authors.forename: Nadine
authors.initials: N
authors.lastname: Ktorza
authors.forename: Hocine
authors.initials: H
authors.lastname: Ait Mohand
authors.forename: Stephanie
authors.initials: S
authors.lastname: Dominguez
authors.forename: Luminita
authors.initials: L
authors.lastname: Schneider
authors.forename: Jade
authors.initials: J
authors.lastname: Ghosn
authors.forename: Michele
authors.initials: M
authors.lastname: Pauchard
authors.forename: Dominique
authors.initials: D
authors.lastname: Costagliola
authors.forename: Christine
authors.initials: C
authors.lastname: Katlama
authors.forename: Vincent
authors.initials: V
authors.lastname: Calvez
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D023241:Antiretroviral Therapy, Highly Active; D024882:Drug Resistance, Viral; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology; D017320:HIV Protease Inhibitors / Q000494:pharmacology*; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D009154:Mutation / Q000235:genetics*; D009705:Nucleosides / Q000494:pharmacology*; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012367:RNA, Viral / Q000235:genetics; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D009705:Nucleosides; D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase