Treatment of hypertension and prevention of ischemic stroke.
Data clearly indicate that treatment with antihypertensive drugs reduces the incidence of all strokes in men (by 34%), women (by 38%), elderly persons (by 36%), including those older than 80 years (by 34%), younger persons, those with systolic and diastolic hypertension, persons with isolated systolic hypertension, and in those with a history of stroke or transient ischemic attack (by 28%). Blood pressure should be reduced to less than 140/90 mm Hg. The overall data also suggest that reduction of stroke in persons with hypertension is related more to a reduction in blood pressure than to the type of antihypertensive drugs used.
Aronow
Wilbert S
WS
Department of Medicine, New York Medical College, Munger Pavilion, Room 263, Valhalla, NY 10595, USA.
Frishman
William H
WH
D000465:Algorithms; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002216:Captopril / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004110:Diltiazem / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D019808:Losartan / Q000627:therapeutic use; D020913:Perindopril / Q000627:therapeutic use; D020521:Stroke / Q000517:prevention & control*
D000959:Antihypertensive Agents; D002216:Captopril; D004110:Diltiazem; D019808:Losartan; D020913:Perindopril