Adaptation of a strain of Plasmodium falciparum from Ghana to Aotus lemurinus griseimembra, A. nancymai, and A. vociferans monkeys.
A strain of Plasmodium falciparum from Ghana was adapted to Aotus lemurinus griseimembra, A. nancymai, and A. vociferans monkeys. Gametocytes in splenectomized A. nancymai were infective to Anopheles freeborni mosquitoes. Sporozoite transmission was accomplished in two splenectomized A. nancymai with prepatent periods of 22 and 25 days. The Ghana III/CDC strain of P. falciparum is susceptible to treatment with chloroquine and mefloquine.
Sullivan
Joann S
JS
Division of Parasitic Diseases and Animal Resources Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
Sullivan
James J
JJ
Williams
Allison
A
Grady
Katharine K
KK
Bounngaseng
Amy
A
Huber
Curtis S
CS
Nace
Douglas
D
Williams
Tyrone
T
Galland
G Gale
GG
Barnwell
John W
JW
Collins
William E
WE
D000220:Adaptation, Biological; D000818:Animals; D000852:Anopheles / Q000469:parasitology; D016645:Aotidae / Q000469:parasitology*; D017931:DNA Primers; D004195:Disease Models, Animal; D005838:Genotype; D005869:Ghana; D017780:Malaria Vaccines; D016778:Malaria, Falciparum / Q000517:prevention & control; D010963:Plasmodium falciparum / Q000235:genetics / Q000502:physiology*; D016133:Polymerase Chain Reaction
D017931:DNA Primers; D017780:Malaria Vaccines