title: Synthesis and electrospray ionization mass spectra of AZT/d4T boranophosphates.
abstract: New anti-HIV prodrugs, conjugates of AZT and d4T with boranophosphates, were prepared by the H-phosphonate method. Their structures were determined by negative ion electrospray ionization mass spectrometry (ESI-MS) in conjunction with tandem mass spectrometry (MS/MS). The fragmentation pathways were investigated, and most of the fragment ions contained the boranophosphate or phosphinate group.
authors.affiliation: Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, PR China.
authors.forename: Changxue
authors.initials: C
authors.lastname: Lin
authors.forename: Hua
authors.initials: H
authors.lastname: Fu
authors.forename: Yufen
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D019380:Anti-HIV Agents / Q000032:analysis / Q000138:chemical synthesis; D001880:Boranes / Q000032:analysis* / Q000138:chemical synthesis; D010710:Phosphates / Q000737:chemistry; D010766:Phosphorylation; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D018119:Stavudine / Q000031:analogs & derivatives / Q000032:analysis* / Q000737:chemistry; D015215:Zidovudine / Q000031:analogs & derivatives / Q000032:analysis* / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D001880:Boranes; D010710:Phosphates; D015215:Zidovudine; D018119:Stavudine