Switching extended 1,3-diequatorial and bent 1,3-diaxial states of a disubstituted hinge sugar by ligand exchange reactions on Pt(II).
The bent conformation of a trisaccharide containing 2,4-diaminoxylopyranoside, in which both end sugars are presented in 1,3-diaxial orientation, is fixed by chelation of the diamino groups to Pt(II) and unfixed by a ligand exchange reaction with NaCN or thiourea giving its extended conformation.
Izumi
Takuhiro
T
Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatsutacho, Midoriku, Yokohama 2268501, Japan.
Hashimoto
Hironobu
H
Yuasa
Hideya
H
D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D008024:Ligands; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D012966:Sodium Cyanide / Q000737:chemistry; D013890:Thiourea / Q000737:chemistry; D014312:Trisaccharides / Q000737:chemistry*
D008024:Ligands; D009944:Organoplatinum Compounds; D014312:Trisaccharides; D010984:Platinum; D013890:Thiourea; D012966:Sodium Cyanide