Predicting relapse after cessation of Lamivudine monotherapy for chronic hepatitis B virus infection.
There have been reports of relapse after cessation of lamivudine monotherapy for hepatitis B virus (HBV) infection. The aim of this study was to examine factors that predict posttreatment relapse. Comparison 22 patients who experienced relapse with 11 who did not after cessation of therapy showed that predictive factors for nonrelapse were hepatitis B e antigen seroconversion and duration of undetectable HBV DNA load (<0.7 log IU/mL), as determined by HBV real-time detection direct testing. However, 7 of 12 patients with seroconversion experienced relapse after cessation of therapy. Multivariate analysis revealed that the duration of an undetectable HBV DNA load was the only independent predictive factor for nonrelapse (odds ratio, 0.50; 95% confidence interval, 0.27-0.9). More-prolonged lamivudine therapy is required after seroconversion, and persistent duration of an HBV DNA level of <0.7 log IU/mL for >6 months can more accurately aid in the decision of when to stop lamivudine therapy.
Ito
Kiyoaki
K
Department of Gastroenterology, Chukyo Hospital, Nagoya, Japan.
Tanaka
Yasuhito
Y
Orito
Etsuro
E
Hirashima
Noboru
N
Ide
Tatsuya
T
Hino
Teruko
T
Kumashiro
Ryukichi
R
Kato
Atunaga
A
Nukaya
Haruhiko
H
Sakakibara
Kenji
K
Mukaide
Motokazu
M
Ito
Hidemi
H
Sata
Michio
M
Ueda
Ryuzo
R
Mizokami
Masashi
M
D000328:Adult; D004279:DNA, Viral / Q000032:analysis / Q000187:drug effects; D005260:Female; D006515:Hepatitis B virus / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D019259:Lamivudine / Q000627:therapeutic use*; D008297:Male; D012008:Recurrence; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D019562:Viral Load
D004279:DNA, Viral; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine