[Study on apoptosis of lung tissue cells in patients with severe brain injury complicated with aspiration-induced lung injury].
OBJECTIVE
To investigate the role of apoptosis of pulmonary cells in aspiration induced lung injury in patients with severe brain injury with or without aspiration-induced lung injury.


METHODS
The Glasgow scale (GCS) of 11 dead patients with severe closed brain injury was 3-8. There 11 cases were divided into aspiration-induced lung injury (AILI) and non-aspiration-induced lung injury (NAILI) groups. The plasma levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) were measured, and the ratio of apoptosis in lung tissue cells was also determined.


RESULTS
The plasma levels of TNF-alpha and IL-8 in NAILI and AILI groups were (2.17+/-0.41)nug/L vs. (3.14+/-0.28)nug/L and (0.42+/-0.05)nug/L vs. (0.91+/-0.08) nug/L (P<0.05) respectively. Lung tissue cell apoptosis ratio was significantly higher in AILI group than NAILI group (P<0.01).


CONCLUSIONS
TNF-alpha and IL-8 may induce apoptosis in lung tissues through different signaling pathway. During the early phase of aspiration-induced lung injury complicating severe closed brain injury, apoptosis in cells of lung tissue may play a role in the pathogenes.
Li
Tan-Shi
TS
Department of Emergency, General Hospital of PLA, Beijing 100853, China.
Yin
Di-Cheng
DC
Wu
Xu-Hui
XH
Song
Yang-Li
YL
Yin
Ming
M
Shen
Hong
H
He
Quan-Ying
QY
D000328:Adult; D017209:Apoptosis; D001344:Autopsy; D001930:Brain Injuries / Q000097:blood / Q000150:complications*; D005260:Female; D006801:Humans; D020287:In Situ Nick-End Labeling; D016209:Interleukin-8 / Q000097:blood; D008168:Lung / Q000473:pathology*; D008297:Male; D011015:Pneumonia, Aspiration / Q000209:etiology; D012128:Respiratory Distress Syndrome / Q000097:blood* / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha