Distribution and antifungal susceptibility of Candida species causing candidemia from 1996 to 1999.
Susceptibilities to amphotericin B and fluconazole of 383 Candida species isolated from blood were determined. Candida albicans was the most common species (55.6%), followed by Candida parapsilosis (17.5%), Candida tropicalis (16.5%), Candida glabrata (5.2%), Candida guilliermondii (2.3%), and others (2.9%). All but three isolates, Candida ciferrii, C. tropicalis, and C. glabrata, one each, were susceptible to amphotericin B. A total of 367 (95.8%) and 15 (4.2%) isolates were susceptible and susceptible-dose dependent to fluconazole, respectively. Only one isolate, a C. glabrata, was resistant to fluconazole. Few patients (13%) having prior fluconazole treatments may explain the low rate of resistance to fluconazole in this study.
Cheng
Ming-Fang
MF
Department of Microbiology, Veterans General Hospital, Kaohsiung, Taiwan.
Yu
Kwok-Woon
KW
Tang
Ran-Bin
RB
Fan
Yu-Hua
YH
Yang
Yun-Liang
YL
Hsieh
Kai-Sheng
KS
Ho
Monto
M
Lo
Hsiu-Jung
HJ
D000666:Amphotericin B / Q000494:pharmacology*; D002175:Candida / Q000145:classification* / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology*; D016469:Fungemia / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D012494:Sampling Studies; D012680:Sensitivity and Specificity
D000666:Amphotericin B; D015725:Fluconazole