[Is the supplementation with antioxidants effective in the treatment of atherosclerosis?].
Results from experimental and epidemiologic studies suggest an influence of oxidative stress on development and progression of atherosclerosis in man. Prospective endpoint studies failed to support this hypothesis. The current literature is summarized in this review.
Schröder
St
S
Medizinische Klinik, Abteilung für Kardiologie, Eberhard-Karls-Universität Tübingen. Stephen.Schroeder@med.uni-tuebingen.de
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000517:prevention & control; D018849:Controlled Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D005609:Free Radicals; D006801:Humans; D008297:Male; D009747:Nutritional Physiological Phenomena; D018384:Oxidative Stress; D010919:Placebos; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D011322:Primary Prevention; D011446:Prospective Studies; D017257:Ramipril / Q000008:administration & dosage / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D013997:Time Factors; D024505:Tocopherols / Q000008:administration & dosage / Q000627:therapeutic use; D014815:Vitamins / Q000008:administration & dosage / Q000627:therapeutic use; D019207:beta Carotene / Q000008:administration & dosage / Q000627:therapeutic use
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D000975:Antioxidants; D005609:Free Radicals; D010919:Placebos; D010975:Platelet Aggregation Inhibitors; D014815:Vitamins; D019207:beta Carotene; D017257:Ramipril; D001205:Ascorbic Acid; D024505:Tocopherols; D001241:Aspirin