title: [The effect of overtraining on human sperm chromatin structure].
abstract: OBJECTIVE
  To identify the effects of overtraining on human sperm DNA.
  
  
  METHODS
  Molecular epidemiological investigation of 249 men from different groups (training and non-training) was carried out by using flow cytometer to detect the integrity and damage of in situ DNA of sperm nucleus, and sperm chromatin structure assay was performed.
  
  
  RESULTS
  The average COMPalpha(t) in training group was 11.02% while that in control group was 5.90% (P < 0.01). COMPalpha(t) was significantly correlated with sperm activity (r = 0.41, P < 0.05).
  
  
  CONCLUSIONS
  Overtraining could induce sperm DNA injury and affect sperm activity, thus to decrease the potentiality of reproduction.
authors.affiliation: Department of Reproductive Center, The 202nd Hospital of PLA, Shenyang 110003, China.
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Ding
authors.forename: Su-wen
authors.initials: SW
authors.lastname: Yan
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Tang
authors.forename: Hai-ou
authors.initials: HO
authors.lastname: Lu
mesh_terms: D000328:Adult; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D053938:DNA Fragmentation; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D013081:Sperm Motility / Q000502:physiology; D013094:Spermatozoa / Q000166:cytology / Q000378:metabolism*
chemical_list: D002843:Chromatin