InvB is required for type III-dependent secretion of SopA in Salmonella enterica serovar Typhimurium.
The Salmonella effector protein SopA is translocated into host cells via the SPI-1 type III secretion system (TTSS) and contributes to enteric disease. We found that the chaperone InvB binds to SopA and slightly stabilizes it in the bacterial cytosol and that it is required for its transport via the SPI-1 TTSS.
Ehrbar
Kristin
K
Institute of Microbiology, ETH Zürich, 8092 Zürich, Switzerland.
Hapfelmeier
Siegfried
S
Stecher
Bärbel
B
Hardt
Wolf-Dietrich
WD
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*; D003600:Cytosol / Q000378:metabolism; D021381:Protein Transport; D012486:Salmonella typhimurium / Q000378:metabolism*; D014158:Transcription, Genetic
D001426:Bacterial Proteins; C088597:invB protein, Salmonella; C060971:SopA protein, Bacteria