[Treatment with statins of the elderly].
BACKGROUND
Previous studies of treatment with statins have included few subjects aged 70 years or above. While the absolute risk of cardiovascular disease in the elderly is very high, the benefits of treatment may be reduced by adverse events, polypharmacy and competing risks.


METHODS
A statistician and a clinician reviewed the Pravastatin in elderly individuals at risk of vascular disease (PROSPER) study and compared the results with subgroup analyses of previous studies.


RESULTS
Subgroup analyses of previous studies showed that treatment with statins reduces cardiovascular events among patients with coronary heart disease aged > or = 65 years. The Heart Protection Study (HPS) included elderly with known atherosclerotic disease, while only 44% of subjects in the PROSPER study had such disease. Among subjects aged 70 or above the difference in events between the groups that received a statin or placebo was 6.1% in the HPS study and 2.1% in the PROSPER study (numbers needed to treat were 6 and 48, respectively). The studies gave conflicting results with regard to stroke and cancer.


CONCLUSIONS
Elderly people with cardiovascular disease may benefit from treatment with statins. We do not have data that show that statins reduce total mortality among the elderly.
Holme
Ingar
I
Avdeling for epidemiologi og helseovervåkning, Klinikk for forebyggende medisin, Ullevål universitetssykehus, Oslo. holme@ulleval.no
Tonstad
Serena
S
D000368:Aged; D000369:Aged, 80 and over; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000401:mortality; D015331:Cohort Studies; D006801:Humans; D017035:Pravastatin / Q000627:therapeutic use*; D011446:Prospective Studies; D012307:Risk Factors
D000924:Anticholesteremic Agents; D017035:Pravastatin