Imaging recognition of multidrug resistance in human breast tumors using 99mTc-labeled monocationic agents and a high-resolution stationary SPECT system.
Imaging recognition of multidrug-resistance by 99mTc-labeled sestamibi, tetrofosmin and furifosmin in mice bearing human breast tumors was evaluated using a high-resolution SPECT, FASTSPECT. Imaging results showed that the washout rates in drug-resistant MCF7/D40 tumors were significantly greater than that in drug-sensitive MCF7/S tumors. Furifosmin exhibited greater washout from both MCF7/S and MCF7/D40 than sestamibi, while tetrofosmin washout was greater than sestamibi in MCF7/D40 only. Feasibility of the monocationic agents for characterizing MDR expression was well clarified with FASTSPECT imaging.
Liu
Zhonglin
Z
Department of Radiology, The University of Arizona, Tucson, AZ 85724 , USA. zliu@radiology.arizona.edu
Stevenson
Gail D
GD
Barrett
Harrison H
HH
Kastis
George A
GA
Bettan
Michael
M
Furenlid
Lars R
LR
Wilson
Donald W
DW
Woolfenden
James M
JM
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000818:Animals; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002412:Cations; D018432:Drug Resistance, Multiple; D019544:Equipment Failure Analysis; D021621:Imaging, Three-Dimensional / Q000295:instrumentation* / Q000379:methods; D008657:Metabolic Clearance Rate; D051379:Mice; D016513:Mice, SCID; D009928:Organ Specificity; D017556:Technetium Compounds / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation* / Q000379:methods
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D002412:Cations; D017556:Technetium Compounds