title: A randomized, double-blind, placebo-controlled pilot study of i.v. immune globulins in combination with i.v. methylprednisolone in the treatment of relapses in patients with MS.
abstract: BACKGROUND
  Some patients with multiple sclerosis (MS) do not show a clear improvement of acute relapses after treatment with intravenous methylprednisolone (IVMP). We compared the efficacy of the combination of intravenous immunoglobulins (IVIg) and IVMP with the standard treatment of IVMP alone in promoting recovery from moderate to severe acute relapses in MS.
  
  
  METHODS
  Patients with clinically definite MS having a relapse with at least a one point increase in Kurtzke's expanded disability status scale (EDSS) in comparison to the preattack EDSS were randomized to IVMP-IVIg or IVMP-placebo treatment. The primary outcome criterion was the EDSS grade at four weeks. A preplanned interim analysis was performed after inclusion of 19 consecutive MS patients to evaluate the sample size necessary for a larger trial.
  
  
  RESULTS
  Both groups had improved one point on the EDSS four weeks after start of treatment (P = 0.81) and one of the stopping rules of the interim analysis was fulfilled. There were also no differences in secondary outcomes: EDSS at eight and 12 weeks, time to improve > or = 1 EDSS points, difference in Scripps score and ambulation index. Five patients in the IVMP-IVIg group and two in the IVMP group had a new relapse in the six month follow-up.
  
  
  CONCLUSIONS
  Our study could not show superiority of IVMP-IVIg in the treatment of moderate to severe acute relapses in MS.
authors.affiliation: Department of Neurology, St. Elisabeth Hospital, Tilburg, The Netherlands. l.visser@elisabeth.nl
authors.forename: L H
authors.initials: LH
authors.lastname: Visser
authors.forename: R
authors.initials: R
authors.lastname: Beekman
authors.forename: C C
authors.initials: CC
authors.lastname: Tijssen
authors.forename: B M J
authors.initials: BM
authors.lastname: Uitdehaag
authors.forename: M L
authors.initials: ML
authors.lastname: Lee
authors.forename: K L L
authors.initials: KL
authors.lastname: Movig
authors.forename: A W
authors.initials: AW
authors.lastname: Lenderink
mesh_terms: D000328:Adult; D004185:Disability Evaluation; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007275:Injections, Intravenous; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D010865:Pilot Projects; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous; D018696:Neuroprotective Agents; D008775:Methylprednisolone