Effect of treating antibody-coated sperm with chymotrypsin on pregnancy rates following IUI as compared to outcome of IVF/ICSI.
Males with 100% of their sperm coated by antisperm antibody have a very small chance of achieving a pregnancy by intercourse or conventional intrauterine insemination (IUI). A previous study found that treatment of the sperm with the protein digestive enzyme chymotrypsin improved the efficacy of IUI. The present study was designed to corroborate or refute this previous study and compare efficacy to IVF with ICSI. This time the subjects were an even more difficult group with 100% of the sperm coated by autoantibodies.
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J H
JH
University of Medicine, Robert Wood Johnson Medical School at Camden, Cooper Hospita, New Jersey, USA.
Hourani
W
W
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M L
ML
Graziano
V
V
Levin
E
E
D000906:Antibodies; D002918:Chymotrypsin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007248:Infertility, Male; D007315:Insemination, Artificial / Q000379:methods*; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000187:drug effects / Q000276:immunology*
D000906:Antibodies; D002918:Chymotrypsin