title: Granuloma annulare in a site of healed herpes zoster: Wolf's isotopic response.
abstract: A case of granuloma annulare that developed in a site of healed herpes zoster is reported. Polymerase chain reaction failed to detect VZV DNA in a biopsy specimen. The occurrence of different types of cutaneous reactions in a body area previously affected by herpes virus infection is known as Wolf's isotopic response. Pathogenesis may be due to a local neuroimmune dysregulation set off by herpesvirus-induced lesions of dermal sensory nerve fibres.
authors.affiliation: Department of Dermatology, Second University of Naples, Naples, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Ruocco
authors.forename: A
authors.initials: A
authors.lastname: Baroni
authors.forename: F Tripodi
authors.initials: FT
authors.lastname: Cutrì
authors.forename: F Grimaldi
authors.initials: FG
authors.lastname: Filioli
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D002990:Clobetasol / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D016460:Granuloma Annulare / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D006562:Herpes Zoster / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D010431:Pentoxifylline / Q000627:therapeutic use; D018570:Risk Assessment; D012540:Scapula; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D002990:Clobetasol; D010431:Pentoxifylline