title: Adaptation of a strain of Plasmodium falciparum from Ghana to Aotus lemurinus griseimembra, A. nancymai, and A. vociferans monkeys.
abstract: A strain of Plasmodium falciparum from Ghana was adapted to Aotus lemurinus griseimembra, A. nancymai, and A. vociferans monkeys. Gametocytes in splenectomized A. nancymai were infective to Anopheles freeborni mosquitoes. Sporozoite transmission was accomplished in two splenectomized A. nancymai with prepatent periods of 22 and 25 days. The Ghana III/CDC strain of P. falciparum is susceptible to treatment with chloroquine and mefloquine.
authors.affiliation: Division of Parasitic Diseases and Animal Resources Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
authors.forename: Joann S
authors.initials: JS
authors.lastname: Sullivan
authors.forename: James J
authors.initials: JJ
authors.lastname: Sullivan
authors.forename: Allison
authors.initials: A
authors.lastname: Williams
authors.forename: Katharine K
authors.initials: KK
authors.lastname: Grady
authors.forename: Amy
authors.initials: A
authors.lastname: Bounngaseng
authors.forename: Curtis S
authors.initials: CS
authors.lastname: Huber
authors.forename: Douglas
authors.initials: D
authors.lastname: Nace
authors.forename: Tyrone
authors.initials: T
authors.lastname: Williams
authors.forename: G Gale
authors.initials: GG
authors.lastname: Galland
authors.forename: John W
authors.initials: JW
authors.lastname: Barnwell
authors.forename: William E
authors.initials: WE
authors.lastname: Collins
mesh_terms: D000220:Adaptation, Biological; D000818:Animals; D000852:Anopheles / Q000469:parasitology; D016645:Aotidae / Q000469:parasitology*; D017931:DNA Primers; D004195:Disease Models, Animal; D005838:Genotype; D005869:Ghana; D017780:Malaria Vaccines; D016778:Malaria, Falciparum / Q000517:prevention & control; D010963:Plasmodium falciparum / Q000235:genetics / Q000502:physiology*; D016133:Polymerase Chain Reaction
chemical_list: D017931:DNA Primers; D017780:Malaria Vaccines