Exploiting the hypoxia response.
Hypoxia (low oxygen) is a defining physiological feature of a number of diseases, including cancer, cardiovascular disease and retinopathy. Hypoxia plays an active role in the pathology of these diseases through its impact on gene expression, thereby making the hypoxia-signaling pathway a key target for the development of novel molecular therapies. This review focuses on how the elucidation of this pathway has led to the development of novel therapeutic strategies, including physiologically targeted gene therapy and the identification of novel therapeutic targets within the hypoxia-signaling pathway.
Binley
Katie
K
Oxford BioMedica, Oxford Science Park, Oxford, OX4 4GA, UK.
Kan
On
O
White
Jonathon
J
Naylor
Stuart
S
D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D000860:Hypoxia / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy*; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism; D011401:Promoter Regions, Genetic; D015398:Signal Transduction / Q000502:physiology*
D011393:Procollagen-Proline Dioxygenase