Treatment of endotoxemia.
Although recognition of clinical signs of endotoxemia is not difficult, determining the underlying cause for the development of endotoxemia may be a challenging task. For this reason, importance must be placed on performance of a thorough physical examination, attention to detail, and determination of whether or not surgical intervention is required. In most instances, a definitive diagnosis may require repeated examinations and laboratory work. In the meantime, affected animals require treatment for endotoxemia, with the aim being to reduce the duration of endotoxemia, prevent the interaction of additional endotoxins with cell surface receptors, and reduce the synthesis and release of inflammatory mediators.
Moore
James N
JN
Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA. jmoore@vet.uga.edu
Barton
Michelle Henry
MH
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D019446:Endotoxemia / Q000209:etiology / Q000628:therapy / Q000662:veterinary*; D004731:Endotoxins / Q000097:blood; D006734:Horse Diseases / Q000209:etiology / Q000628:therapy*; D006736:Horses; D018836:Inflammation Mediators / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D018805:Sepsis / Q000628:therapy / Q000662:veterinary
D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004731:Endotoxins; D018836:Inflammation Mediators; D011956:Receptors, Cell Surface