title: [Infant botulism and sudden infant death syndrome].
abstract: Infant botulism represents a distinct entity of botulism. Ingestion of the ubiquitously present spores of Clostridium botulinum leads to germination of the organism and neurotoxin production in the infant intestine. Symptoms typically develop gradually in contrast to classical food botulism in which an acute onset of symptoms shortly after the ingestion of preformed toxin in a food is characteristic. Microbiologically, the diagnosis is established by identification of Clostridium botulinum organism and toxin in stool specimen. However, positive results in these tests provide only indirect evidence for the clinical relevance of the neurotoxin since asymptomatic carriers have been found. The toxin irreversibly blocks the release of acetylcholin from the motoric end plate which results in muscle weakness and paralysis. Depending on the amount of toxin produced, infant botulism exhibits a broad clinical spectrum ranging from oligosymptomatic forms to a fulminant course with acute respiratory failure within hours leading to sudden death. Unrecognized mild forms or beginning muscle weakness can be a co-factor for other risk factors of sudden infant death (SIDS). In studies analyzing infants who died from SIDS, botulism bacteria or toxin were found in up to 20 % of cases. Infant botulism therefore represents an important differential diagnosis of unexplained and inconclusive muscular hypotonia in the first year of life.
authors.affiliation: Universitäts-Kinderklinik Wuerzburg.
authors.forename: U
authors.initials: U
authors.lastname: Bartram
authors.forename: D
authors.initials: D
authors.lastname: Singer
mesh_terms: D000109:Acetylcholine / Q000037:antagonists & inhibitors; D001905:Botulinum Toxins / Q000633:toxicity; D001906:Botulism / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D002423:Cause of Death; D003014:Clostridium botulinum / Q000472:pathogenicity; D006801:Humans; D007223:Infant; D007422:Intestines / Q000382:microbiology; D009045:Motor Endplate / Q000187:drug effects; D010243:Paralysis / Q000175:diagnosis / Q000209:etiology / Q000401:mortality; D013398:Sudden Infant Death / Q000453:epidemiology / Q000209:etiology*; D014774:Virulence
chemical_list: D001905:Botulinum Toxins; D000109:Acetylcholine