title: [Keratoacanthoma: two cases with intravascular spread].
abstract: We report two patients with keratoacanthoma, simple in one and multiple in the other, displaying typical histological features except for intravascular spread. Although this spread points to malignancy, it did not allow to rule out the diagnosis of keratoacanthoma. These aggressive histological features, as well as perineural invasion, are not linked to malignant clinical course, according to the literature. Intravascular spread suggests that keratoancanthoma could be considered as a peculiar form of well differentiated squamous cell carcinoma. Comparison between clinical and pathological observations should lead to more specific diagnosis.
authors.affiliation: Service d'Anatomie et de Cytologie Pathologiques, CHR d'Orléans, Hôpital de la Source, BP 6709, 45067 Orléans 2.
authors.forename: Annabel
authors.initials: A
authors.lastname: Gottfarstein-Maruani
authors.forename: Patrick
authors.initials: P
authors.lastname: Michenet
authors.forename: Rémy
authors.initials: R
authors.lastname: Kerdraon
authors.forename: Carole
authors.initials: C
authors.lastname: Bonneau
authors.forename: Anne
authors.initials: A
authors.lastname: Heitzmann
authors.forename: Eric
authors.initials: E
authors.lastname: Estève
authors.forename: Roger-Claude
authors.initials: RC
authors.lastname: Rémy
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007633:Keratins / Q000032:analysis; D007636:Keratoacanthoma / Q000473:pathology* / Q000601:surgery; D008297:Male; D009361:Neoplasm Invasiveness; D012878:Skin Neoplasms / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D007633:Keratins