title: GENIUS II: a high-throughput database system for linking ORFs in complete genomes to known protein three-dimensional structures.
abstract: GENIUS II is an automated database system in which open reading frames (ORFs) in complete genomes are assigned to known protein three-dimensional (3D) structures. The system uses the multiple intermediate sequence search method in which query and target sequences are linked by intermediate sequences gathered by PSI-BLAST search. By applying the system to 129 complete genomes, 43.8% on average of the ORFs in the genomes were assigned to known 3D structures and the results are available for free at GENIUS II web site.
authors.affiliation: Computational Biology Research Center (CBRC), National Institute of Advanced Industrial Science and Technology (AIST), Aomi Frontier Building 17F, 2-43 Aomi, Koto-ku, Tokyo 135-0064, Japan.
authors.forename: Yukimitsu
authors.initials: Y
authors.lastname: Yabuki
authors.forename: Yuri
authors.initials: Y
authors.lastname: Mukai
authors.forename: Mark B
authors.initials: MB
authors.lastname: Swindells
authors.forename: Makiko
authors.initials: M
authors.lastname: Suwa
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D003628:Database Management Systems; D030562:Databases, Protein; D016678:Genome; D016247:Information Storage and Retrieval / Q000379:methods*; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics*; D011487:Protein Conformation; D011506:Proteins / Q000032:analysis / Q000737:chemistry* / Q000235:genetics*; D016415:Sequence Alignment / Q000379:methods*; D020539:Sequence Analysis, Protein / Q000379:methods*; D013223:Statistics as Topic
chemical_list: D011506:Proteins