Effects of cocaine on heart rate variability in healthy subjects.
In this study, we found that cocaine decreased the high-frequency power of heart rate variability in normal volunteers, implicating a decrease in vagal tone. However, the results of our autonomic blocking studies indicated the opposite, suggesting a major influence of cardiac sympathetic drive on the high-frequency power of heart rate variability.
Vongpatanasin
Wanpen
W
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA. wanpen.vongpatanasin@utsouthwestern.edu
Taylor
J Andrew
JA
Victor
Ronald G
RG
D000281:Administration, Intranasal; D000328:Adult; D001340:Autonomic Nerve Block; D002302:Cardiac Output / Q000187:drug effects* / Q000502:physiology; D002316:Cardiotonic Agents / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D012016:Reference Values
D002316:Cardiotonic Agents; D003042:Cocaine