title: Failure of argatroban anticoagulation during off-pump coronary artery bypass surgery.
abstract: Heparin-induced antibodies create vexing problems during cardiac surgery. Although alternative medications have been used for intraoperative anticoagulation, the results have been sufficiently variable that no one medication is recommended. In our case, due to the poor reversibility of the antithrombin agents, argatroban was chosen as a heparin substitute due to its short half-life and its anticoagulation assessment using the activated clotting time (ACT). Unfortunately, our experience was that argatroban does not provide adequate anticoagulation during off-pump coronary bypass surgery, even when the ACT is maintained at more than 380 sec.
authors.affiliation: Department of Anesthesiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. marcann@wfubmc.edu
authors.forename: Mark A
authors.initials: MA
authors.lastname: Cannon
authors.forename: John
authors.initials: J
authors.lastname: Butterworth
authors.forename: Robert D
authors.initials: RD
authors.lastname: Riley
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Hyland
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000601:surgery*; D000906:Antibodies / Q000097:blood; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D001120:Arginine / Q000031:analogs & derivatives; D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D023903:Coronary Restenosis / Q000601:surgery*; D004305:Dose-Response Relationship, Drug; D006083:Graft Occlusion, Vascular / Q000209:etiology; D006493:Heparin / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009204:Myocardial Revascularization; D010314:Partial Thromboplastin Time; D010875:Pipecolic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D012086:Reoperation; D015607:Stents; D013449:Sulfonamides; D017211:Treatment Failure
chemical_list: D000906:Antibodies; D000925:Anticoagulants; D010875:Pipecolic Acids; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban