title: High phosphorus diet changes phosphorus metabolism regardless of PTH action in rats.
abstract: In this study, we ascertained whether the parathyroid hormone (PTH) dominantly regulated the effects of high phosphorus (P) intakes on urinary excretion of P and bone metabolism in rats. To maintain serum PTH level equally, parathyroidectomy (PTX) and sham-operated rats were constantly exposed to rPTH(1-34) and fed both control (0.3% P) and high P (1.2% P) diet for 7 days, respectively. Urinary excretions of P and C-terminal telopeptides of type I collagen were significantly increased in both PTX and sham rats by the high P diet. These results suggest that high P diet increased urinary P excretion while promoting bone resorption regardless of PTH-dependent regulation.
authors.affiliation: Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture.
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Katsumata
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Masuyama
authors.forename: Moyuru
authors.initials: M
authors.lastname: Koshihara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsuzaki
authors.forename: Mariko
authors.initials: M
authors.lastname: Uehara
authors.forename: Kazuharu
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D004032:Diet; D004435:Eating / Q000187:drug effects; D008297:Male; D010281:Parathyroid Hormone / Q000378:metabolism*; D016105:Parathyroidectomy; D010446:Peptide Fragments / Q000097:blood / Q000494:pharmacology; D010758:Phosphorus / Q000378:metabolism* / Q000494:pharmacology* / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D019379:Teriparatide / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology
chemical_list: D010281:Parathyroid Hormone; D010446:Peptide Fragments; D019379:Teriparatide; D010758:Phosphorus; C035748:parathyroid hormone (1-34)amide