title: Regulation of glyceroneogenesis and phosphoenolpyruvate carboxykinase by fatty acids, retinoic acids and thiazolidinediones: potential relevance to type 2 diabetes.
abstract: Recent studies brought adipocyte glyceroneogenesis back to the fore as an important pathway in fatty acid homeostasis and underlined the key role played by cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) in this pathway. The present review analyses the mechanisms by which a series of hormones and nutrients affect PEPCK-C gene transcription and glyceroneogenesis and describes evidence for disregulation of this pathway in type 2 diabetes.
authors.affiliation: UMR-S 530 Inserm-Université René Descartes, centre Universitaire-U.F.R. Biomédicale, 45, rue des Saints-Pères, 75006 Paris, France.
authors.forename: Joan
authors.initials: J
authors.lastname: Tordjman
authors.forename: Wael
authors.initials: W
authors.lastname: Khazen
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Antoine
authors.forename: Geneviève
authors.initials: G
authors.lastname: Chauvet
authors.forename: Joelle
authors.initials: J
authors.lastname: Quette
authors.forename: Françoise
authors.initials: F
authors.lastname: Fouque
authors.forename: Elmus G
authors.initials: EG
authors.lastname: Beale
authors.forename: Chantal
authors.initials: C
authors.lastname: Benelli
authors.forename: Claude
authors.initials: C
authors.lastname: Forest
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000378:metabolism / Q000503:physiopathology; D005227:Fatty Acids / Q000494:pharmacology*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D005990:Glycerol / Q000378:metabolism*; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000235:genetics* / Q000378:metabolism*; D045162:Thiazolidinediones / Q000494:pharmacology*; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D005227:Fatty Acids; D045162:Thiazolidinediones; D014212:Tretinoin; C089946:2,4-thiazolidinedione; D010729:Phosphoenolpyruvate Carboxykinase (GTP); D005990:Glycerol