title: Low dose 2-CdA schedule activity in splenic marginal zone lymphomas.
abstract: Splenic Marginal Zone Lymphoma (SMZL) is a rare clinicopathological entity among marginal zone lymphomas. SMZL is an indolent lymphoma usually treated by splenectomy. A subset of patients is characterized by a more aggressive clinical course and poor prognosis. Treatment of these cases and second-line therapy for relapsed patients have not been yet identified. We report 10 cases treated with cladribrine (5 mg/m(2)/week) for six courses. Six patients (60%) achieved partial response, two patients (20%) achieved a complete response and the two remaining patients did not respond and died as a result of progression of the disease. The treatment was well tolerated. A total of 60% of the patients had an overall survival rate of 48 months and 24 months progression-free-survival was achieved by 37% with a median time of progression-free-survival of 17 months. Interestingly, in addition to a relevant percentage of hematological remission, some patients also experienced a molecular remission. We conclude that this treatment is safe and well tolerated and is able to induce a substantial number of responses. Our results suggest that this schedule is well tolerated and could be an useful alternative to splenectomy.
authors.affiliation: Haematology Division, Department of Oncology, Transplant and Advanced Technologies, University of Pisa, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Riccioni
authors.forename: F
authors.initials: F
authors.lastname: Caracciolo
authors.forename: S
authors.initials: S
authors.lastname: Galimberti
authors.forename: N
authors.initials: N
authors.lastname: Cecconi
authors.forename: M
authors.initials: M
authors.lastname: Petrini
mesh_terms: D015762:2-Chloroadenosine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use*; D003839:Deoxyadenosines / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D008875:Middle Aged; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000188:drug therapy* / Q000401:mortality; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D003839:Deoxyadenosines; D015762:2-Chloroadenosine; C055994:2-chloro-3'-deoxyadenosine