title: Gm (23) allotypes and Fcgamma receptor genotypes as risk factors for various forms of periodontitis.
abstract: OBJECTIVE
  Given the diversity of the distribution of the Gm (23) allotypes and FcgammaR genotypes in different ethnic groups, it was our purpose to examine their clinical significance in periodontitis in Taiwan.
  
  
  METHODS
  Genomic DNA of 50 patients with chronic periodontitis (CP), 30 patients with generalized aggressive periodontitis (G-AP) and 74 healthy controls were harvested. The Gm (23) allotypes were determined by radial immunodiffusion test, and the FcgammaR IIa (CD32) and IlIb (CD16) genotypes were determined by polymerase chain reaction-based allele-specific oligonucleotide hybridization.
  
  
  RESULTS
  The overall carrier rate of the Gm (23+) allotype was higher than 85%, and the Gm (23-) allotype was statistically over-represented in patients with CP compared to the controls. There were no differences in the distributions of the three genotypes of FcgammaR IIa and IIIb among the three tested groups. The frequency of the R131 allele of the FcgammaR IIa polymorphisms was higher in G-AP than in CP when R/H allelic frequencies (p = 0.01) were examined by the chi2 test.
  
  
  CONCLUSIONS
  The Gm (23-) allotype might be a potential risk factor for CP. Although the R131 allele of FcgammaR IIa occurred more frequently in G-AP than in CP, its clinical significance could not be justified in this study.
authors.affiliation: Department of Dentistry, China Medical College Hospital, Taiwan.
authors.forename: Hsien-Yang
authors.initials: HY
authors.lastname: Chung
authors.forename: Hsi-chi
authors.initials: HC
authors.lastname: Lu
authors.forename: Woan-Ling
authors.initials: WL
authors.lastname: Chen
authors.forename: Chun-Tai
authors.initials: CT
authors.lastname: Lu
authors.forename: Yi-Hsin
authors.initials: YH
authors.lastname: Yang
authors.forename: Chi-Cheng
authors.initials: CC
authors.lastname: Tsai
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000097:blood / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016009:Chi-Square Distribution; D002908:Chronic Disease; D005260:Female; D058851:GPI-Linked Proteins; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010518:Periodontitis / Q000097:blood / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D011110:Polymorphism, Genetic / Q000235:genetics; D017452:Receptors, IgG / Q000097:blood / Q000235:genetics*; D012016:Reference Values; D012307:Risk Factors; D013624:Taiwan
chemical_list: D015703:Antigens, CD; C428200:FCGR3B protein, human; C080568:Fc gamma receptor IIA; D058851:GPI-Linked Proteins; C483744:Gm(23) allotype; D007129:Immunoglobulin Gm Allotypes; D017452:Receptors, IgG