title: Optimal management for surgically Stage 1 serous cancer of the uterus.
abstract: OBJECTIVE
  To describe the outcomes of patients who have undergone well-conducted surgery and found to have Stage 1 serous uterine cancer.
  
  
  METHODS
  This retrospective cohort study includes women who have been treated for Stage 1 serous cancer of the uterus from 1985 to 2001. Cases were included from the regional cancer centers in Hamilton, London, Sunnybrook Toronto and Cancer Care Manitoba.
  
  
  RESULTS
  Forty-three women met the inclusion criteria: Complete surgical staging (n = 27), surgery followed by pelvic radiation therapy (n = 4), surgery followed by whole abdominal radiation therapy (n = 6), surgery followed by adjuvant chemotherapy (n = 6). Patient age or depth of invasion did not influence survival. Progression free interval was 22 months (SD = 14.29). Recurrence rate was highest for adjuvant chemotherapy (66%). Survival was assessed by treatment modality and a statistically significant poorer survival was seen in the adjuvant chemotherapy group (OR 17.5; 95% CI 1.3-227.6). No comment can be made on a superior treatment regimen given the small numbers in each treatment strata.
  
  
  CONCLUSIONS
  This study supports the findings of others in the literature. In a group of patients where surgical staging shows limited disease (i.e., surgically Stage 1 disease), then surgery alone appears to be adequate treatment.
authors.affiliation: Hamilton Regional Cancer Centre, Hamilton, Ontario, Canada. Laurie.Elit@hrcc.on.ca
authors.forename: L
authors.initials: L
authors.lastname: Elit
authors.forename: J
authors.initials: J
authors.lastname: Kwon
authors.forename: J
authors.initials: J
authors.lastname: Bentley
authors.forename: K
authors.initials: K
authors.lastname: Trim
authors.forename: I
authors.initials: I
authors.lastname: Ackerman
authors.forename: M
authors.initials: M
authors.lastname: Carey
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D016896:Treatment Outcome; D014594:Uterine Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*