Biologically active platinum complexes containing 8-thiotheophylline and 8-(methylthio)theophylline.
Complexes [Pt(mu-N,S-8-TT)(PPh(3))(2)](2) (1), [Pt(mu-S,N-8-TT)(PTA)(2)](2) (2), [Pt(8-TTH)(terpy)]BF(4) (3), cis-[PtCl(8-MTT)(PPh(3))(2)] (4), cis-[Pt(8-MTT)(2)(PPh(3))(2)] (5), cis-[Pt(8-MTT)(8-TTH)(PPh(3))(2)] (6), cis-[PtCl(8-MTT)(PTA)(2)] (7), cis-[Pt(8-MTT)(2)(PTA)(2)] (8), and trans-[Pt(8-MTT)(2)(py)(2)] (9) (8-TTH(2) = 8-thiotheophylline; 8-MTTH = 8-(methylthio)theophylline; PTA = 1,3,5-triaza-7-phosphaadamantane) are presented and studied by IR and multinuclear ((1)H, (31)P[(1)H]) NMR spectroscopy. The solid-state structure of 4 and 9 has been authenticated by X-ray crystallography. Growth inhibition of the cancer cells T2 and SKOV3 induced by the above new thiopurine platinum complexes has been investigated. The activity shown by complexes 4 and 9 was comparable with cisplatin on T2. Remarkably, 4 and 9 displayed also a valuable activity on cisplatin-resistant SKOV3 cancer cells.
Romerosa
A
A
Area de Química Inorgánica, Facultad de Ciencias Experimentales, Universidad de Almería, 04071 Almería, Spain. romerosa@ual.es
Bergamini
P
P
Bertolasi
V
V
Canella
A
A
Cattabriga
M
M
Gavioli
R
R
Mañas
S
S
Mantovani
N
N
Pellacani
L
L
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D045744:Cell Line, Tumor; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002945:Cisplatin / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D008968:Molecular Conformation; D008970:Molecular Weight; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D011725:Pyridines / Q000737:chemistry; D013806:Theophylline / Q000031:analogs & derivatives / Q000737:chemistry*
C483401:8-(methylthio)theophylline; C483400:8-thiotheophylline; D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D008024:Ligands; D009944:Organoplatinum Compounds; D011725:Pyridines; D013806:Theophylline; C023666:pyridine; D002945:Cisplatin