title: The course of cognitive decline in older persons: results from the longitudinal aging study amsterdam.
abstract: The course of cognitive functioning in older persons was studied over a period of 6 years. The first aim was to distinguish cognitive decline as a temporary state from progressive cognitive decline. The second aim was to identify predictors which may be useful in discriminating persons with temporary cognitive decline from persons with progressive cognitive decline at an early stage. Data were derived from the Longitudinal Aging Study Amsterdam (LASA), a population-based study in the Netherlands. The results show that 18.2% of the sample of older persons showed cognitive decline over a period of 3 years. Of this group, 44% recovered from cognitive decline or stayed stable in the next 3 years. Especially older age, memory complaints and an increase of cardiovascular diseases at follow-up predict further deterioration.
authors.affiliation: Department of Psychiatry, Institute for Research in Extramural Medicine (EMGO Institute) of the VU University Medical Center, Amsterdam, The Netherlands. h.comijis.emgo@med.vu.nl
authors.forename: Hannie C
authors.initials: HC
authors.lastname: Comijs
authors.forename: Miranda G
authors.initials: MG
authors.lastname: Dik
authors.forename: Dorly J H
authors.initials: DJ
authors.lastname: Deeg
authors.forename: Cees
authors.initials: C
authors.lastname: Jonker
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology*; D003072:Cognition Disorders / Q000453:epidemiology / Q000523:psychology*; D003863:Depression / Q000150:complications / Q000523:psychology; D018450:Disease Progression; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008569:Memory Disorders / Q000523:psychology; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D009483:Neuropsychological Tests; D012016:Reference Values; D012307:Risk Factors; D012959:Socioeconomic Factors