title: Effect of indoor environmental factors on development of atopic symptoms in children followed up to 4 years of age.
abstract: The increased prevalence of atopic diseases reported in many Western countries is thought to be caused by changes in living conditions. For a long time attention was focused on indoor environmental factors and early feeding patterns, but during recent years other factors have received more attention. An unselected, Swedish, population-based cohort of 904 children were followed from the age of 3 months to 4 years. Questionnaires were sent to the mothers of the children when they were 3 months, 18 months and 4 years of age. A blood sample was taken from a subgroup of the children when they were 4 years old which was analysed for IgE specific antibodies to food and inhalant allergens. The prevalences of asthma, allergic eye-nose reactions, eczema, and food reactions at 4 years of age and a positive blood test were analysed as outcome factors. Features of housing and early feeding patterns were found to have limited effect on the development of allergies in the children. Presence of older siblings resulted in a decreased tendency to produce IgE antibodies. Early exposure to furry animals seemed to prevent the development of asthma. Children who were frequently infected up to 18 months of age showed an increased prevalence of allergic symptoms at 4 years of age. Children of mothers with a higher prevalence of complaints about indoor factors, or who had increased general symptoms or skin or mucous membrane symptoms ran a greater risk of developing various allergic symptoms. However, these children did not have higher levels of IgE antibodies. The reported allergic symptoms in the children may be due to non-immunological reactions, although it is also possible that the mothers may have over-reported such symptoms.
authors.affiliation: Department of Paediatrics, Orebro University Hospital, Orebro, Sweden. dan.gustafsson@orebroll.se
authors.forename: Dan
authors.initials: D
authors.lastname: Gustafsson
authors.forename: Kjell
authors.initials: K
authors.lastname: Andersson
mesh_terms: D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000453:epidemiology / Q000209:etiology; D015331:Cohort Studies; D003139:Common Cold / Q000150:complications; D004485:Eczema / Q000453:epidemiology / Q000209:etiology; D004777:Environment; D005260:Female; D005500:Follow-Up Studies; D005512:Food Hypersensitivity / Q000453:epidemiology / Q000209:etiology; D006798:Housing; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013548:Sweden / Q000453:epidemiology
chemical_list: D000485:Allergens; D007073:Immunoglobulin E