title: A rare case of intravascular lymphoma diagnosed on bone marrow trephine.
abstract: Intravascular lymphoma (IVL) is an extremely rare form of extra-nodal non-Hodgkins lymphoma characterised by the proliferation of neoplastic lymphocytes within the lumina of small arteries, veins and capillaries. The great majority of reported cases appear to be of B cell lineage. There is a wide variation in clinical presentation, and multiple organs are usually affected. We report a case of a 67-year-old man who presented with constitutional symptoms and neurological deficit and was diagnosed following bone-marrow trephine. His disease responded to polychemotherapy treatment but he died 15 months after diagnosis. This case in unusual in that it is generally felt that bone marrow is relatively spared until late in the disease and is often not clearly demonstrable histologically. In addition, this case supports the limited data that responses can be obtained following polychemotherapy treatment, although the prognosis remains generally poor.
authors.affiliation: Department of Medicine, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK. nick.maisey@rmh.nthames.nhs.uk
authors.forename: N R
authors.initials: NR
authors.lastname: Maisey
authors.forename: J S
authors.initials: JS
authors.lastname: Waters
authors.forename: D
authors.initials: D
authors.lastname: Collins
authors.forename: J
authors.initials: J
authors.lastname: Schofield
authors.forename: M E
authors.initials: ME
authors.lastname: Hill
mesh_terms: D000368:Aged; D001706:Biopsy / Q000379:methods; D001853:Bone Marrow / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis*; D008297:Male; D019043:Vascular Neoplasms / Q000175:diagnosis*