title: Noninvasive monitoring of hemoglobin. The effects of WBC counts on measurement.
abstract: The efficacy of a noninvasive hemoglobin monitoring device (Astrin, Sysmex, Kobe, Japan) was evaluated for healthy volunteers and for patients with hematologic disorders. At the same time, the effects of WBC counts on noninvasive monitoring were studied by clinical evaluation and in ex vivo experiments. The hemoglobin levels determined by the device (Ast-Hb) and a conventional analyzer (T-Hb) were compared. The coefficient of correlation between findings with the Ast-Hb and the T-Hb for healthy volunteers was r = 0.626, whereas that for patients with hematologic disorders was r = 0.762. A comparison of the ratios of measurement errors in hemoglobin levels by Ast-Hb and T-Hb indicated that the number of WBCs had no effect on hemoglobin monitoring. Moreover, ex vivo studies using isolated WBCs and an optical model that imitates blood vessels and tissue in human fingers confirmed these results. Therefore, this new hemoglobin monitoring device can be expected to be useful for continuous hemoglobin monitoring.
authors.affiliation: Blood Transfusion Division, Kobe University Hospital, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
authors.forename: Katsuyasu
authors.initials: K
authors.lastname: Saigo
authors.forename: Shion
authors.initials: S
authors.lastname: Imoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Hashimoto
authors.forename: Hisashi
authors.initials: H
authors.lastname: Mito
authors.forename: Junko
authors.initials: J
authors.lastname: Moriya
authors.forename: Tadanobu
authors.initials: T
authors.lastname: Chinzei
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Kubota
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Numada
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Ozawa
authors.forename: Shunichi
authors.initials: S
authors.lastname: Kumagai
mesh_terms: D005260:Female; D006402:Hematologic Diseases / Q000097:blood*; D006452:Hemoglobinometry / Q000295:instrumentation / Q000379:methods*; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D007259:Infrared Rays; D007958:Leukocyte Count; D008297:Male; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods*
chemical_list: D006454:Hemoglobins