Immunomodulatory constituents from an Ascomycete, Chaetomium seminudum.
A screening study focusing on immunomodulatory activity of the EtOAc extract of an Ascomycete, Chaetomium seminudum, has afforded a known epipolythiodioxopiperazine, chetomin (1), together with three new chetomin-related metabolites named chetoseminudins A (2), B (3), and C (4). Among these four metabolites, 1 and 2 have been deduced as the immunosuppressive features of this fungus.
Fujimoto
Haruhiro
H
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. h-fujimoto@faculty.chiba-u.jp
Sumino
Megumi
M
Okuyama
Emi
E
Ishibashi
Masami
M
D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002597:Chaetomium / Q000737:chemistry*; D004220:Disulfides; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D026121:Indole Alkaloids; D007564:Japan; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D013154:Spleen / Q000166:cytology
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D004220:Disulfides; D006576:Heterocyclic Compounds, 4 or More Rings; D026121:Indole Alkaloids; C483272:chetoseminudin A; C483273:chetoseminudin B; C483274:chetoseminudin C; C001598:chetomin