Cell-transforming activity of fourteen chemical agents used in dental practice in Syrian hamster embryo cells.
Fourteen chemical agents used in dental practice were assessed for their cell-transforming activity using the Syrian hamster embryo (SHE) cell transformation assay system. The cell-transforming activity was quantitatively assessed by the frequency of morphological transformation (MT) in SHE cells induced by these agents. MT was induced by m-cresol, guaiacol, formaldehyde, sodium hypochlorite, hydrogen peroxide, sodium arsenite, acid fuchsin, and basic fuchsin, but not by p-chlorophenol, p-phenolsulfonic acid, glutaraldehyde, and erythrosine B. Iodine and chlorhexidine exhibited positive and pseudopositive responses, respectively. The chemical agents exhibiting a negative or pseudopositive response neither induced nor enhanced MT even in the presence of exogenous metabolic activation.
Yamaguchi
Fusae
F
Department of Pharmacology, The Nippon Dental University, School of Dentistry at Tokyo, Japan.
Tsutsui
Takeki
T
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000633:toxicity*; D015197:Carcinogenicity Tests; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D002478:Cells, Cultured; D006224:Cricetinae; D003813:Dentistry; D004202:Disinfectants / Q000633:toxicity*; D004622:Embryo, Mammalian / Q000166:cytology; D008647:Mesocricetus
D000891:Anti-Infective Agents, Local; D004202:Disinfectants