title: Microwave-assisted Paal-Knorr reaction. A rapid approach to substituted pyrroles and furans.
abstract: [reaction: see text] An array of tetrasubstituted pyrroles (and trisubstituted furans) was obtained using a simple three-step procedure. Functional homologation of a beta-ketoester with an aldehyde followed by oxidation gave a series of differently substituted 1,4-dicarbonyl compounds that can be rapidly cyclized with the Paal-Knorr procedure carried out under microwave irradiation.
authors.affiliation: Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy.
authors.forename: Giacomo
authors.initials: G
authors.lastname: Minetto
authors.forename: Luca F
authors.initials: LF
authors.lastname: Raveglia
authors.forename: Maurizio
authors.initials: M
authors.lastname: Taddei