Evaluation of the fully automated Bactec MGIT 960 system for the susceptibility testing of Mycobacterium tuberculosis to first-line drugs: a multicenter study.
The accuracy of the Bactec MGIT 960 system for susceptibility testing of 177 clinical isolates of Mycobacterium tuberculosis to first line drugs (isoniazid, rifampicin, ethambutol and streptomycin) was compared with the agar reference method. The sensitivity, the ability to detect resistance, of the MGIT system was 100%, while the specificity, the ability to detect susceptibility, ranged from 98.6% to 100% for all drugs tested.
Kontos
Fanourios
F
Department of Microbiology, Medical School, University Hospital of Larissa, Papakyriazi 22, Larissa, Greece. anm@otenet.gr
Maniati
Maria
M
Costopoulos
Christos
C
Gitti
Zoe
Z
Nicolaou
Stavroula
S
Petinaki
Efymia
E
Anagnostou
Spyridoula
S
Tselentis
Ioannis
I
Maniatis
Antonios N
AN
D000995:Antitubercular Agents / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial; D004977:Ethambutol / Q000494:pharmacology; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000379:methods*; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D011933:Reagent Kits, Diagnostic; D012293:Rifampin / Q000494:pharmacology; D012680:Sensitivity and Specificity; D013307:Streptomycin / Q000494:pharmacology; D014376:Tuberculosis / Q000382:microbiology
D000995:Antitubercular Agents; D011933:Reagent Kits, Diagnostic; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin