[NSAIDs digestive risk: epidemiologic data].
A HIGH RISK: Conventional non-steroidal anti-inflammatory drugs (NSAIDs) produce, by a factor of about 4, a major increase of the secondary GI adverse effect risk (ulcer and bleeding). According to published data, the number of patients to be treated with an NSAID for a duration of more than 2 months, a duration which can result in death, is 1220 (909 to 2500). A LONG TERM RISK: The GI risk induced by an NSAID appears constant over time. Upon discontinuation of treatment with an NSAID, an elevated risk is observed during the first 3 months following the end of treatment.
Ravaud
Philippe
P
Département d'épidémiologie, biostatistique et recherche clinique, Hôpital Bichat, Paris.
Chaussade
Stanislas
S
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D016021:Epidemiologic Studies; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D013276:Stomach Ulcer / Q000139:chemically induced
D000894:Anti-Inflammatory Agents, Non-Steroidal