title: Parvovirus B19-related chronic monoarthritis: immunohistochemical detection of virus-positive lymphocytes within the synovial tissue compartment: two reported cases.
abstract: Apart from systemic symptoms of viral infection parvovirus B19, the infectious agent in erythema infectiosum, can lead to mainly self-limited acute and chronic arthropathy. Because mild subclinical features of the disease can be easily overlooked, joint affections might appear as isolated symptoms. We here report two cases of chronic monoarthritic symptoms of unknown origin, where immunohistochemical detection of B19-positive lymphocytic cells in the synovial tissue led to the diagnosis of B19 arthropathy. In conclusion, respective virus diagnostics should be considered even in chronic monosymptomatic arthritic lesions. The pathology of B19 arthropathy seems to be due to direct virus infection of cells within the synovia.
authors.affiliation: Department of Human Genetics, Institut für Humangenetik, Saarland University, Universitätskliniken Geb. 60, 66421, Homburg/Saar, Germany.
authors.forename: Carsten
authors.initials: C
authors.lastname: Lennerz
authors.forename: Henning
authors.initials: H
authors.lastname: Madry
authors.forename: Sandra
authors.initials: S
authors.lastname: Ehlhardt
authors.forename: Thorsten
authors.initials: T
authors.lastname: Venzke
authors.forename: Klaus D
authors.initials: KD
authors.lastname: Zang
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Mehraein
mesh_terms: D000328:Adult; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D001170:Arthritis, Infectious / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D036022:Capsid Proteins / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007719:Knee Joint / Q000473:pathology / Q000821:virology; D008214:Lymphocytes / Q000473:pathology / Q000821:virology*; D008297:Male; D010322:Parvoviridae Infections / Q000150:complications* / Q000473:pathology; D016732:Parvovirus B19, Human / Q000302:isolation & purification* / Q000472:pathogenicity; D013583:Synovial Membrane / Q000473:pathology / Q000821:virology*
chemical_list: D000914:Antibodies, Viral; D036022:Capsid Proteins; C095547:capsid protein VP1, parvovirus B19; C095548:capsid protein VP2, parvovirus B19