Cerebral sinovenous thrombosis in a nephrotic child.
Nephrotic syndrome in infancy and childhood is known to be associated with a hypercoagulable state and thromboembolic complications, but cerebral sinovenous thrombosis (CST) is a very rare and serious one, with only a few isolated reports in the literature. A case is presented of a 9-year-old boy with nephrotic syndrome that acutely developed signs and symptoms of intracranial hypertension syndrome. CST was diagnosed on cranial CT and MRI and he gradually recovered after treatment with anticoagulants. The diagnosis of CST should be considered in any patient with nephrotic syndrome who develops neurologic symptoms. The discussion of this case, coupled with a review of the literature, emphasizes that early diagnosis is essential for institution of anticoagulation therapy and a successful outcome. This report also illustrates the difficulties that may be encountered in managing such a patient.
Rodrigues
Marcelo Masruha
MM
Department of Neurology, Federal University of São Paulo, São Paulo, SP, Brazil. mmasruha@ig.com.br
Zardini
Lilian Rocha
LR
de Andrade
Maria Cristina
MC
Mangia
Cristina Malzoni Ferreira
CM
Carvalhaes
João Tomas de Abreu
JT
Vilanova
Luiz Celso Pereira
LC
D002648:Child; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications* / Q000175:diagnosis; D010690:Phlebography; D011856:Radiographic Image Enhancement; D012851:Sinus Thrombosis, Intracranial / Q000150:complications* / Q000175:diagnosis; D014057:Tomography, X-Ray Computed