title: Epilepsy surgery, resection volume and MSI localization in lesional frontal lobe epilepsy.
abstract: To verify whether interictal noninvasive information detected by magnetoencephalography (MEG) recordings can contribute to localize focal epileptic activity relevant for seizure generation in lesional frontal lobe epilepsy, magnetic source imaging (MSI) localizations of epileptic discharges were compared to the extent of neurosurgical resection and postoperative outcome. Preoperative MEG spike localizations were displayed in postoperative magnetic resonance imaging (MRI) scans to check whether dipole sites were located within the resection cavity. Moreover, MEG localizations were compared with results of prolonged video-EEG monitoring and, in three cases, with invasive EEG recordings. Our results in five cases with lesional frontal lobe epilepsy showed that good surgical outcome could be achieved in those patients where the majority of MEG spike localizations were located within the resected brain volume.
authors.affiliation: Neurological Clinic, Department of Neurology, Epilepsy Center, University Erlangen-Nürnberg, D-91054, Erlangen, Germany. Alexandra.Genow@neuro.imed.uni-erlangen.de
authors.forename: A
authors.initials: A
authors.lastname: Genow
authors.forename: C
authors.initials: C
authors.lastname: Hummel
authors.forename: G
authors.initials: G
authors.lastname: Scheler
authors.forename: R
authors.initials: R
authors.lastname: Hopfengärtner
authors.forename: M
authors.initials: M
authors.lastname: Kaltenhäuser
authors.forename: M
authors.initials: M
authors.lastname: Buchfelder
authors.forename: J
authors.initials: J
authors.lastname: Romstöck
authors.forename: H
authors.initials: H
authors.lastname: Stefan
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000503:physiopathology / Q000601:surgery*; D004569:Electroencephalography; D017034:Epilepsy, Frontal Lobe / Q000503:physiopathology* / Q000601:surgery*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D008297:Male; D012008:Recurrence; D012086:Reoperation; D014741:Video Recording