title: Measurement of bone morphogenetic proteins and other growth factors in demineralized bone matrix.
abstract: Osteoinductivity of demineralized bone matrix has been attributed to bone morphogenetic proteins (BMP). Other growth factors, including insulin-like growth factor-1 (IGF-1) and transforming growth factor-beta1 (TGF-beta1), have also been detected in demineralized bone matrix. Success of bone graft substitutes containing demineralized bone matrix has been assumed to be closely associated with osteoinductivity of the demineralized bone matrix. Because of differences in bone characteristics between donors and tissue banks, confirmation and measurement of osteoinductivity may play a crucial role in predicting the success of the bone graft substitute. In the current studies, BMP-2, BMP-4, TGF-beta1, and IGF-1 were measured in demineralized bone matrix. A strong association was noted between BMP-2 and TGF-beta1 levels. A strong association was also found between BMP-2 and new bone formation in an ectopic nude rat model.
authors.affiliation: Wright Medical Technology, Inc., Arlington, Tenn, USA.
authors.forename: Barbara
authors.initials: B
authors.lastname: Blum
authors.forename: Jon
authors.initials: J
authors.lastname: Moseley
authors.forename: Leasa
authors.initials: L
authors.lastname: Miller
authors.forename: Kelly
authors.initials: K
authors.lastname: Richelsoph
authors.forename: Warren
authors.initials: W
authors.lastname: Haggard
mesh_terms: D018775:Bone Demineralization Technique; D001857:Bone Matrix / Q000737:chemistry*; D019485:Bone Morphogenetic Proteins / Q000032:analysis*; D006133:Growth Substances / Q000032:analysis*; D006801:Humans
chemical_list: D019485:Bone Morphogenetic Proteins; D006133:Growth Substances