First functionalized MRI contrast agent recognizing vascular lesions.
A new MRI-contrast agent, EB-DTPA-Gd, that has an Evans Blue analogue as a sensing unit for endothelium lesions, was designed and synthesized. The agent also has diethylenetriamine-N,N,N',N",N"-pentaacetic acid-Gd complex (Gadolinium-DTPA) units, which have been used as detection units for T1-weighted MRI. The EB-DTPA-Gd was able to recognize and adsorb to the vascular endothelium-denuded region of porcine aorta, and to decrease the relaxation time of circumferential water's protons, making possible MR imaging of the endothelium-denuded region. The compound can be employed as a contrast agent for the imaging of vascular lesions using MRI.
Yamamoto
Tatsuhiro
T
Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812-8581, Japan.
Ikuta
Kenjiro
K
Oi
Keiji
K
Abe
Kohtaro
K
Uwatoku
Toyokazu
T
Murata
Masaharu
M
Shigetani
Noboru
N
Yoshimitsu
Kengo
K
Shimokawa
Hiroaki
H
Katayama
Yoshiki
Y
D003287:Contrast Media; D019786:Gadolinium DTPA / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D014652:Vascular Diseases / Q000175:diagnosis*
D003287:Contrast Media; C483332:EB-DTPA-Gd; D019786:Gadolinium DTPA