[Antisense oligonucleotides with pharmacologic action].
The potential therapeutic applications of the antisense strategy are illustrated by numerous examples of the oligonucleotides investigated in preclinical and clinical trials especially for antiviral, antiinflammatory, anticancer and antiatherosclerotic activity. The main advantages of the antisense oligonucleotides therapeutic candidates are comparatively discussed with the classical drugs.
Tauşer
Roxana-Georgiana
RG
Disciplina de Chimie farmaceutică, Facultatea de Farmacie, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
Stoica
Ortansa
O
D001161:Arteriosclerosis / Q000188:drug therapy; D002986:Clinical Trials as Topic; D017726:Cytomegalovirus Retinitis / Q000188:drug therapy; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use*; D016896:Treatment Outcome
D016376:Oligonucleotides, Antisense