Cortical motor activation in akinetic schizophrenic patients: a pilot functional MRI study.
Akinesia is associated with supplementary motor area (SMA) dysfunction in Parkinson's disease. We looked for a similar association in patients with schizophrenia. Using functional magnetic resonance imaging (fMRI), we compared motor activation in 6 akinetic neuroleptic-treated schizophrenic patients and 6 normal subjects. Schizophrenic patients had a defective activation in the SMA, left primary sensorimotor cortex, bilateral lateral premotor and inferior parietal cortices, whereas the right primary sensorimotor cortex and a mesial frontal area were hyperactive. SMA was hypoactive in akinetic schizophrenic patients, emphasizing the role of this area in motor slowness. Other abnormal signals likely reflect schizophrenia-related abnormal intracortical connections.
Payoux
Pierre
P
INSERM U 455, and PET Center, University Hospital of Toulouse, France.
Boulanouar
Kader
K
Sarramon
Christine
C
Fabre
Nelly
N
Descombes
Sylvie
S
Galitsky
Monique
M
Thalamas
Claire
C
Brefel-Courbon
Christine
C
Sabatini
Umberto
U
Manelfe
Claude
C
Chollet
François
F
Schmitt
Laurent
L
Rascol
Olivier
O
D000328:Adult; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D007839:Functional Laterality / Q000502:physiology; D006179:Gyrus Cinguli / Q000503:physiopathology; D006225:Hand / Q000294:innervation; D006801:Humans; D018476:Hypokinesia / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009044:Motor Cortex / Q000503:physiopathology*; D010296:Parietal Lobe / Q000503:physiopathology*; D010865:Pilot Projects; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time / Q000502:physiology; D012016:Reference Values; D012559:Schizophrenia / Q000175:diagnosis / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012691:Serial Learning / Q000502:physiology; D013003:Somatosensory Cortex / Q000503:physiopathology*