Effect of caffeine administered intravenously on intracoronary-administered adenosine-induced coronary hemodynamics in patients with coronary artery disease.
It is believed that caffeine attenuates the coronary hyperemic response to adenosine by blocking the A2a receptors. We studied the effect of caffeine on adenosine-induced myocardial hyperemia measured by fractional flow reserve after intracoronary adenosine administration. Fractional flow reserve was not affected by intravenous caffeine infusion at a dose that was comparable to oral consumption.
Aqel
Raed A
RA
Division of Cardiovascular Disease, Birmingham's Veterans Affair Medical Center, and Department of Medicine, University of Alabama at Birmingham, 35233, USA. raqel@cardio.dom.uab.edu
Zoghbi
Gilbert J
GJ
Trimm
James R
JR
Baldwin
Shawn A
SA
Iskandrian
Ami E
AE
D000241:Adenosine / Q000008:administration & dosage*; D058917:Adenosine A2 Receptor Antagonists; D000328:Adult; D002110:Caffeine / Q000008:administration & dosage*; D003324:Coronary Artery Disease / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology*; D007262:Infusions, Intravenous; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D014665:Vasodilator Agents / Q000008:administration & dosage*
D058917:Adenosine A2 Receptor Antagonists; D014665:Vasodilator Agents; D002110:Caffeine; D000241:Adenosine