A mild and efficient procedure for alpha-bromination of ketones using N-bromosuccinimide catalysed by ammonium acetate.
Cyclic ketones reacted with N-bromosuccinimide (NBS) catalysed by NH(4)OAc in Et(2)O at 25 degrees C to give the corresponding alpha-brominated ketones in good yields, while acyclic ketones were efficiently brominated in CCl(4) at 80 degrees C.
Tanemura
Kiyoshi
K
School of Dentistry at Niigata, The Nippon Dental University, Hamaura-cho, Niigata 951-8580, Japan. tanemura@ngt.ndu.ac.jp
Suzuki
Tsuneo
T
Nishida
Yoko
Y
Satsumabayashi
Koko
K
Horaguchi
Takaaki
T