Oxygenation of thiolates to S-bonded sulfinate in an iron III complex related to nitrile hydratase.
Air oxidation of the iron(III) complex derived from (2-mercaptoisobutyryl)-4,5-dichloro-O-phenylenediamine in the presence of Et4NCN afforded the corresponding disulfinato species. With two carboxamido nitrogens trans to two S-bonded sulfinates, this complex mimics the disulfinate inactive form of Fe-NHase.
Galardon
Erwan
E
Laboratoire de Chimie et Biochimie Toxicologiques et Pharmacologiques, UMR8601 CNRS, Université René Descartes, 45 rue des St-Pères, 75270 Paris Cedex 06, France.
Giorgi
Michel
M
Artaud
Isabelle
I
D005290:Ferric Compounds / Q000378:metabolism*; D006836:Hydro-Lyases / Q000378:metabolism*; D008968:Molecular Conformation; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013438:Sulfhydryl Compounds / Q000737:chemistry / Q000378:metabolism*; D013440:Sulfides / Q000737:chemistry / Q000378:metabolism*; D013816:Thermodynamics
D005290:Ferric Compounds; D013438:Sulfhydryl Compounds; D013440:Sulfides; D006836:Hydro-Lyases; C048831:nitrile hydratase