title: Gene expression profiling of breast carcinomas using nylon DNA arrays.
abstract: Clinically very heterogeneous, breast cancer prognosis and treatment response are difficult to predict with the current prognostic histoclinical parameters. Mammary oncogenesis remains poorly understood. DNA array technology allows the simultaneous analysis of the mRNA expression levels of thousands of genes in biological samples. Applied to breast tumours, expression profiles will boost our knowledge of oncogenesis, will offer new potential therapeutic targets and new prognostic and predictive markers. Today, the most accessible approach for academic research teams is that of Nylon DNA arrays with radioactive detection, which in addition allows profiling of small clinical samples.
authors.affiliation: Departement d'oncologie moléculaire, TAGC, Institut Paoli-Calmettes (IPC), IFR57, 232, bd Ste-Marguerite, 13273 Marseille cedex 9, France. bertuccif@marseille.fnclcc.fr
authors.forename: François
authors.initials: F
authors.lastname: Bertucci
authors.forename: Béatrice
authors.initials: B
authors.lastname: Loriod
authors.forename: Valéry
authors.initials: V
authors.lastname: Nasser
authors.forename: Samuel
authors.initials: S
authors.lastname: Granjeaud
authors.forename: Rebecca
authors.initials: R
authors.lastname: Tagett
authors.forename: Anne-Chantal
authors.initials: AC
authors.lastname: Braud
authors.forename: Viens
authors.initials: V
authors.lastname: Patrice
authors.forename: Rémi
authors.initials: R
authors.lastname: Houlgatte
authors.forename: Birnbaum
authors.initials: B
authors.lastname: Daniel
authors.forename: Catherine
authors.initials: C
authors.lastname: Nguyen
mesh_terms: D001943:Breast Neoplasms / Q000145:classification / Q000235:genetics*; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D009757:Nylons; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D011379:Prognosis
chemical_list: D009757:Nylons