title: Association of obesity and cancer risk in Canada.
abstract: The authors conducted a population-based, case-control study of 21,022 incident cases of 19 types of cancer and 5,039 controls aged 20-76 years during 1994-1997 to examine the association between obesity and the risks of various cancers. Compared with people with a body mass index of less than 25 kg/m(2), obese (body mass index of > or = 30 kg/m(2)) men and women had an increased risk of overall cancer (multivariable adjusted odds ratio = 1.34, 95% confidence interval (CI): 1.22, 1.48), non-Hodgkin's lymphoma (odds ratio = 1.46, 95% CI: 1.24, 1.72), leukemia (odds ratio = 1.61, 95% CI: 1.32, 1.96), multiple myeloma (odds ratio = 2.06, 95% CI: 1.46, 2.89), and cancers of the kidney (odds ratio = 2.74, 95% CI: 2.30, 3.25), colon (odds ratio = 1.93, 95% CI: 1.61, 2.31), rectum (odds ratio = 1.65, 95% CI: 1.36, 2.00), pancreas (odds ratio = 1.51, 95% CI: 1.19, 1.92), breast (in postmenopausal women) (odds ratio = 1.66, 95% CI: 1.33, 2.06), ovary (odds ratio = 1.95, 95% CI: 1.44, 2.64), and prostate (odds ratio = 1.27, 95% CI: 1.09, 1.47). Overall, excess body mass accounted for 7.7% of all cancers in Canada-9.7% in men and 5.9% in women. This study provides further evidence that obesity increases the risk of overall cancer, non-Hodgkin's lymphoma, leukemia, multiple myeloma, and cancers of the kidney, colon, rectum, breast (in postmenopausal women), pancreas, ovary, and prostate.
authors.affiliation: Surveillance and Risk Assessment Division, Centre for Chronic Disease Prevention and Control, Population and Public Health Branch, Health Canada, Ottawa, Ontario, Canada. Saiyi_Pan@hc-sc.gc.ca
authors.forename: Sai Yi
authors.initials: SY
authors.lastname: Pan
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Johnson
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Ugnat
authors.forename: Shi Wu
authors.initials: SW
authors.lastname: Wen
authors.forename: Yang
authors.initials: Y
authors.lastname: Mao
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002170:Canada / Q000453:epidemiology; D016022:Case-Control Studies; D016001:Confidence Intervals; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology*; D009765:Obesity / Q000150:complications*; D011159:Population Surveillance / Q000379:methods*; D012307:Risk Factors; D012907:Smoking; D013002:Somatomedins; D011795:Surveys and Questionnaires
chemical_list: D013002:Somatomedins