title: Stent implantation in the ductus arteriosus for pulmonary blood supply in congenital heart disease.
abstract: Indications for catheter-based interventions in patent ductus arteriosus (PDA)-dependent pulmonary blood flow have yet to be defined. The aim of this study was to assess the acute and midterm outcome after stent implantation in the PDA. Between 1996 and 2002, ductal stenting was performed in 21 neonates and infants (14 females/7 males) to maintain pulmonary blood supply in cyanotic congenital heart disease (CHD). Balloon-expandable stents were implanted in the PDA with a final diameter of 4-5 mm without procedural deaths. Stent patency was achieved for 8-1,130 days (median, 142). Reintervention was necessary in nine patients. Overall survival rate after 6 years was 86%. Two neonates died a few days after the procedure due to right heart failure not related to PDA stenting. Corrective surgery was possible in six patients. An additional aortopulmonary shunt was needed in three patients; Fontan type operations were performed in six. One patient died after bidirectional Glenn shunt, another five reached palliation by additional perforation of the atretic valve/balloon valvuloplasty, and two are awaiting surgery. We conclude that in many patients with cyanotic CHD, especially in those with ductal pulmonary perfusion and additional forward flow from the right ventricle, ductal stenting is an effective transcatheter approach. Morphology of the PDA predicts the risk of restenosis and necessity of reintervention. Growth of the pulmonary vascular bed allows corrective or palliative surgery, and some patients can be cured by the intervention alone.
authors.affiliation: Pediatric Heart Center, Justus Liebig University, Giessen, Germany. ina.michel-behnke.@paediat.med.uni-giessen.de
authors.forename: Ina
authors.initials: I
authors.lastname: Michel-Behnke
authors.forename: Hakan
authors.initials: H
authors.lastname: Akintuerk
authors.forename: Josef
authors.initials: J
authors.lastname: Thul
authors.forename: Juergen
authors.initials: J
authors.lastname: Bauer
authors.forename: Karl-Juergen
authors.initials: KJ
authors.lastname: Hagel
authors.forename: Dietmar
authors.initials: D
authors.lastname: Schranz
mesh_terms: D006328:Cardiac Catheterization / Q000379:methods; D004374:Ductus Arteriosus, Patent / Q000175:diagnosis / Q000601:surgery*; D018618:Echocardiography, Doppler, Color; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011666:Pulmonary Valve Stenosis / Q000175:diagnosis / Q000601:surgery*; D015607:Stents; D016896:Treatment Outcome