title: High frequency electrical stimulation attenuates progressive necrosis and cavitation following spinal cord injury.
abstract: This study evaluates the influence of preconditioning by following electrical stimulation on primary and secondary lesion formation following spinal cord injury in rats. The dorsal surface of the spinal cord was stimulated (500 Hz. 10 pulses/train, inter train interval of 10 sec. for 2 hrs) at the T7 level 24 hrs before a right side hemisection, carried out immediately after injury and maintained every 24 hrs for 7 days. Preconditioning by electrical stimulation of the spinal cord activates reactive astrocytes and significantly attenuates edema and progressive necrosis and cavitation, concerning especially the primary (1, 3 weeks post injury) and secondary (24 hrs, 1, 3 weeks post injury) lesion volume. The results suggest that pre-conditioning by electrical stimulation prevents spinal cord secondary lesion formation after injury, and that the beneficial effect is provided by astroglial cells with regard to their ability to attenuate trauma induced cellular cascades.
authors.affiliation: Department of Neurosurgery, Oita Medical University, Oita, Japan. fujiki@oita-med.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Fujiki
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: M
authors.initials: M
authors.lastname: Isono
mesh_terms: D000818:Animals; D018450:Disease Progression; D004599:Electric Stimulation Therapy; D005260:Female; D009336:Necrosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013119:Spinal Cord Injuries / Q000473:pathology* / Q000628:therapy*; D013997:Time Factors