title: 3-(2-pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity human 5-HT(1B/1D) ligands.
abstract: A series of 3-(2-pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives (2) has been prepared using parallel synthesis techniques, and their structure-activity relationships studied. High affinity human 5-HT(1B/1D) (h5-HT(1B/1D)) ligands have been identified.
authors.affiliation: NPS Pharmaceuticals Inc, 6850 Goreway Dr, Mississauga, Ontario, Canada L4V 1V7. iegle@npsp.com
authors.forename: Ian
authors.initials: I
authors.lastname: Egle
authors.forename: Neil
authors.initials: N
authors.lastname: MacLean
authors.forename: Lidia
authors.initials: L
authors.lastname: Demchyshyn
authors.forename: Louise
authors.initials: L
authors.lastname: Edwards
authors.forename: Abdelmalik
authors.initials: A
authors.lastname: Slassi
authors.forename: Ashok
authors.initials: A
authors.lastname: Tehim
mesh_terms: D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000378:metabolism*; D008024:Ligands; D011725:Pyridines / Q000737:chemistry* / Q000378:metabolism*; D044302:Receptor, Serotonin, 5-HT1B / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D007211:Indoles; D008024:Ligands; D011725:Pyridines; D044302:Receptor, Serotonin, 5-HT1B