title: Osteopontin identified as colon cancer tumor progression marker.
abstract: Identifying molecular markers for colon cancer is a top priority. Using a pooled sample approach with Affymetrix GeneChip technology, we assayed colon cancers derived from a series of clinical stages to identify molecular markers of potential prognostic value. Of 12000 genes assessed, osteopontin emerged as the leading candidate tumor progression marker. Osteopontin is a secreted glycoprotein known to bind integrins and CD44. Its actual molecular function remains elusive but its increased expression correlates strongly with tumor progression.
authors.affiliation: Department of Cell Biology, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA.
authors.forename: Deepak
authors.initials: D
authors.lastname: Agrawal
authors.forename: Tingan
authors.initials: T
authors.lastname: Chen
authors.forename: Rosalyn
authors.initials: R
authors.lastname: Irby
authors.forename: John
authors.initials: J
authors.lastname: Quackenbush
authors.forename: Ann F
authors.initials: AF
authors.lastname: Chambers
authors.forename: Marianna
authors.initials: M
authors.lastname: Szabo
authors.forename: Alan
authors.initials: A
authors.lastname: Cantor
authors.forename: Domenico
authors.initials: D
authors.lastname: Coppola
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Yeatman
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D053495:Osteopontin; D012313:RNA / Q000032:analysis; D012795:Sialoglycoproteins / Q000032:analysis* / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; C506895:SPP1 protein, human; D012795:Sialoglycoproteins; D053495:Osteopontin; D012313:RNA