title: Role of beta-blocker therapy in heart failure and atrial fibrillation.
abstract: Heart failure is a serious disorder associated with substantial morbidity and mortality. Approximately 15-30% patients with systolic heart failure are in atrial fibrillation and the proportion increases with severity of heart failure. Patients with heart failure and atrial fibrillation have worse outcome than those in sinus rhythm. Beta-blockers, together with angiotensin-converting enzymes inhibitors, are the standard therapy in patients with chronic heart failure. Retrospective studies have suggested that despite the improvement in left ventricular systolic function after treatment with beta-blockers, the exercise capacity and symptoms in those heart failure patients with atrial fibrillation was not improved as much as those in sinus rhythm. Moreover, the use of bisoprolol in the Cardiac Insufficiency Bisoprolol Study II, unlike those in sinus rhythm, failed to produce any survival benefit in patients with poor systolic function and atrial fibrillation. It seems that those patients with heart failure and atrial fibrillation may have different response to beta-blocker therapy. Prospective trials to clarify the impact of beta-blocker therapy and the optimal therapeutic strategy in this high-risk group of patients are warranted.
authors.affiliation: Division of Cardiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China. jwhfung@cuhk.edu.hk
authors.forename: Jeffrey W H
authors.initials: JW
authors.lastname: Fung
authors.forename: Cheuk M
authors.initials: CM
authors.lastname: Yu
authors.forename: Leo C C
authors.initials: LC
authors.lastname: Kum
authors.forename: Gabriel W K
authors.initials: GW
authors.lastname: Yip
authors.forename: John E
authors.initials: JE
authors.lastname: Sanderson
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D017298:Bisoprolol / Q000627:therapeutic use; D017079:Exercise Tolerance; D006333:Heart Failure / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D016277:Ventricular Function, Left
chemical_list: D000319:Adrenergic beta-Antagonists; D017298:Bisoprolol