Hydrogen-bonded polymer gel and its application as a temperature-sensitive drug delivery system.
The mixture of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer (F-68) and poly vinyl alcohol (PVA) forms a polymer complex gel by intra/intermolecular interaction via hydrogen bonding in water, which is verified by differential scanning calorimetry. With 30 wt% F-68 aqueous solution and 15 wt% PVA aqueous solution, F-68/PVA complex gel was prepared and its swelling transition was observed at approximately 37 degrees C. Based on the temperature-sensitivity of hydrogen bondings in F-68/PVA complex gel, temperature sensitive drug delivery system has been designed and characterized. For the stability in the aqueous media, F-68/PVA complex gel was prepared with a form of polymeric bead, followed by the encapsulation with poly(lactide-co-glycolide) membrane. With changing the ratio of F-68/PVA, the swelling transition of polymer complex gel was manipulated and pulsatile release of acetoaminophen, used as a model drug, was demonstrated in response to pulsatile change of temperature between 35 degrees C and 40 degrees C.
Oh
Keun Sang
KS
Department of Polymer Science and Engineering Hannam University, 133 Ojeong Dong, Daedeog Ku, Taejeon 306-791, South Korea.
Han
Sung Kyun
SK
Choi
Young Whan
YW
Lee
Jin Ho
JH
Lee
Ji Youl
JY
Yuk
Soon Hong
SH
D000082:Acetaminophen / Q000008:administration & dosage* / Q000737:chemistry*; D002214:Capsules / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D045424:Complex Mixtures / Q000737:chemistry; D004058:Diffusion; D016503:Drug Delivery Systems / Q000295:instrumentation / Q000379:methods*; D005782:Gels / Q000737:chemistry; D006860:Hydrogen Bonding; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D008970:Molecular Weight; D044367:Phase Transition; D011092:Polyethylene Glycols / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011409:Propylene Glycols / Q000737:chemistry*; D013499:Surface Properties; D013696:Temperature
D002214:Capsules; D020099:Coated Materials, Biocompatible; D045424:Complex Mixtures; D005782:Gels; C116176:PEO-PPO-PEO; D011108:Polymers; D011409:Propylene Glycols; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D000082:Acetaminophen; D011092:Polyethylene Glycols; D011142:Polyvinyl Alcohol