Anti-HIV-1 protostane triterpenes and digeranylbenzophenone from trunk bark and stems of Garcinia speciosa.
Three new protostanes, garciosaterpenes A ( 1), B ( 2) and C ( 3), together with a new digeranylbenzophenone, garciosaphenone A ( 4) were isolated from the ethyl acetate fractions obtained from the crude methanol extracts of the trunk bark and stems of Garcinia speciosa. The structures were elucidated by spectroscopic methods and chemical reactions. Compounds 1 and 3 showed significant inhibitory activities (IC (50) 15.5 and 12.2 microg/mL, respectively) against HIV-1 reverse transcriptase and in the syncytium assay (EC (50) 5.8 microg/mL with TI 3.4 and 37.0 microg/mL with TI 1.9, respectively). Compound 4 was active in HIV-1 RT assay (IC (50) 23.9 microg/mL), but toxic in the syncytium assay. This work represents the first report on the anti-HIV-1 activities of the protostane triterpenes.
Rukachaisirikul
Vatcharin
V
Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla,Thailand.
Pailee
Phanruethai
P
Hiranrat
Assdhawut
A
Tuchinda
Patoomratana
P
Yoosook
Chalobon
C
Kasisit
Jittra
J
Taylor
Walter C
WC
Reutrakul
Vichai
V
D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001577:Benzophenones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D029760:Garcinia; D054303:HIV Reverse Transcriptase / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018547:Plant Stems; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
D019380:Anti-HIV Agents; D001577:Benzophenones; D010936:Plant Extracts; D018894:Reverse Transcriptase Inhibitors; D014315:Triterpenes; D054303:HIV Reverse Transcriptase