In vitro activities of new antimicrobials against Nocardia brasiliensis.
The in vitro sensitivities of 30 strains of Nocardia brasiliensis to DA-7867, gatifloxacin, moxifloxacin, and BMS-284756 (garenoxacin) were determined using the broth microdilution method. All N. brasiliensis strains were sensitive to these antimicrobials. The most active drug in vitro was DA-7867, with a MIC at which 90% of the isolates tested were inhibited of 0.03 micro g/ml and a MIC at which 50% of the isolates tested were inhibited of 0.06 micro g/ml.
Vera-Cabrera
Lucio
L
Laboratorio Interdisciplinario de Investigación Dermatológica, Servicio de Dermatología, Hospital Universitario, Monterrey, Nuevo León, México. luvera_99@yahoo.com
Gonzalez
Eva
E
Choi
Sung H
SH
Welsh
Oliverio
O
D000890:Anti-Infective Agents / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009615:Nocardia / Q000187:drug effects*; D009617:Nocardia Infections / Q000382:microbiology; D023303:Oxazolidinones / Q000494:pharmacology*; D017192:Skin Diseases, Bacterial / Q000382:microbiology; D013449:Sulfonamides / Q000494:pharmacology
D000890:Anti-Infective Agents; C480487:DA-7867; D023303:Oxazolidinones; D013449:Sulfonamides