PTTG mRNA expression in primary breast cancer: a prognostic marker for lymph node invasion and tumor recurrence.
The proto-oncogene pituitary tumor-transforming gene (PTTG) is described as abundantly overexpressed in a variety of neoplasms and cancer cell lines. We analyzed PTTG mRNA expression in 72 tumor samples derived from primary tumors of patients suffering from breast cancer and in unaffected breast epithelium, checking for correlations between expression levels and standard clinico-pathological parameters over a 5-year observation period. We found a direct correlation between PTTG mRNA overexpression and lymph node infiltration. Furthermore, overexpression of this gene in tumors correlated with a higher degree of tumor recurrence within the subsequent observation period. Taken together, these results demonstrate that determination of PTTG expression in primary tumors of the breast is a powerful tool for the assessment of potential tumor aggressiveness.
Solbach
Christine
C
Department of Gynecology and Obstetrics, School of Medicine, Johann Wolfgang Goethe University, Theodor-Stern Kai 7, Frankfurt am Main 60590, Germany. solbach@em.uni-frankfurt.de
Roller
Marc
M
Fellbaum
Christian
C
Nicoletti
Maria
M
Kaufmann
Manfred
M
D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008207:Lymphatic Metastasis; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D009364:Neoplasm Recurrence, Local / Q000378:metabolism* / Q000473:pathology; D011237:Predictive Value of Tests; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger / Q000032:analysis; D064249:Securin
D014408:Biomarkers, Tumor; C000715470:MAS1 protein, human; D009363:Neoplasm Proteins; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger; D064249:Securin; C578002:pituitary tumor-transforming protein 1, human