title: [Effect of oral intake of an enteric capsule preparation containing Bifidobacterium longum on the progression of chronic renal failure].
abstract: Since the accumulation of intestinal putrefactive products, such as indole and phenol, is known to play a role in the exacerbation of chronic renal failure, reduction of these intestinal putrefactive products can be expected to retard the progression of renal failure. In the present study, an enteric capsule preparation containing Bifidobacterium longum(Bifidus HD) was administered orally to 27 patients with chronic renal failure(CRF) for 6 months. Though no significant effect was found in the whole group, a significant retardation of the progression of renal failure was found in patients with an initial serum creatinine level > or = 4.0 mg/dl or those with an initial serum inorganic phosphate level > or = 4.0 mg/dl. There was no adverse effect observed in any case. Bifidus HD is considered a useful tool for suppressing the progression of chronic renal failure(CRF) in the conservative period.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Jichi Medical School, Tochigi, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ando
authors.forename: Yukio
authors.initials: Y
authors.lastname: Miyata
authors.forename: Kaichiro
authors.initials: K
authors.lastname: Tanba
authors.forename: Osamu
authors.initials: O
authors.lastname: Saito
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Muto
authors.forename: Megumi
authors.initials: M
authors.lastname: Kurosu
authors.forename: Sumiko
authors.initials: S
authors.lastname: Homma
authors.forename: Eiji
authors.initials: E
authors.lastname: Kusano
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Asano
mesh_terms: D000284:Administration, Oral; D000368:Aged; D001644:Bifidobacterium; D002214:Capsules; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged
chemical_list: D002214:Capsules