Serum lipids in children 3 to 5 years after kidney, liver, and heart transplantation.
Although dyslipidemia is common after solid organ transplantation (Tx), there are few long-term studies in children. We investigated the prevalence of dyslipidemia up to 5 years after Tx in 125 children on triple immunosuppression with one of three different well-functioning grafts, kidney, liver, and heart, and 181 controls. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) concentrations were measured annually. Low-density lipoprotein cholesterol concentrations were also calculated. The risk factors for dyslipidemia were determined at 3 years. There was a high prevalence of hypertriglyceridaemia in all three groups, 50% in the kidney transplantation (KTx) and heart transplantation (HTx) groups and 30% in the liver transplantation (LTx) group. In addition, 50% of KTx patients had high TC. In the Tx groups taken together, the following independent associations were observed: KTx and high pre-Tx TC were associated with high TC, high trough concentration of blood cyclosporine with low HDL-C, and older age at Tx accounted for higher TG. Dyslipidemia, especially hypertriglyceridaemia, was common 3-5 years after Tx. The aetiology is multifactorial and depends on the transplanted organ.
Siirtola
Arja
A
Paediatric Research Centre, University of Tampere, 33014 Tampere, Finland. arja.siirtola@uta.fi
Antikainen
Marjatta
M
Ala-Houhala
Marja
M
Koivisto
Anna-Maija
AM
Solakivi
Tiina
T
Jokela
Hannu
H
Lehtimäki
Terho
T
Holmberg
Christer
C
Salo
Matti K
MK
D001827:Body Height; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology; D016027:Heart Transplantation / Q000502:physiology*; D006801:Humans; D015228:Hypertriglyceridemia / Q000453:epidemiology; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D016030:Kidney Transplantation / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D008078:Cholesterol, LDL; D007166:Immunosuppressive Agents; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol