title: Association between tumor necrosis factor-alpha promoter polymorphism and Alzheimer's disease.
abstract: Tumor necrosis factor-alpha (TNFalpha) gene polymorphisms have been reported to be associated with Alzheimer's disease (AD) in Caucasian populations. Three TNFalpha polymorphisms (-857, -863, and -1,031) were studied in a Chinese population. A high-risk TNFalpha haplotype (-1,031C-863C-857C) with an odds ratio of 2.54 (95% CI 1.37 to 4.79) for AD was identified. No interaction effect of APOE and TNFalpha genotypes was found, but both acted as important risk factors for AD.
authors.affiliation: Department of Chemical Pathology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, China.
authors.forename: Suk Ling
authors.initials: SL
authors.lastname: Ma
authors.forename: Nelson L S
authors.initials: NL
authors.lastname: Tang
authors.forename: Linda C W
authors.initials: LC
authors.lastname: Lam
authors.forename: Helen F K
authors.initials: HF
authors.lastname: Chiu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012306:Risk; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E; D014409:Tumor Necrosis Factor-alpha