Cutting edge: conventional CD8 alpha+ dendritic cells are generally involved in priming CTL immunity to viruses.
Dendritic cells (DCs) play a central role in initiating immune responses. Despite this, there is little understanding how different DC subsets contribute to immunity to different pathogens. CD8alpha(+) DC have been shown to prime immunity to HSV. Whether this very limited capacity of a single DC subset priming CTL immunity is restricted to HSV infection or is a more general property of anti-viral immunity was examined. Here, we show that the CD8alpha(+) DCs are the principal DC subset that initiates CTL immunity to s.c. infection by influenza virus, HSV, and vaccinia virus. This same subset also dominated immunity after i.v. infection with all three viruses, suggesting a similar involvement in other routes of infection. These data highlight the general role played by CD8alpha(+) DCs in CTL priming to viral infection and raises the possibility that this DC subset is specialized for viral immunity.
Belz
Gabrielle T
GT
Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
Smith
Christopher M
CM
Eichner
Daniel
D
Shortman
Ken
K
Karupiah
Guna
G
Carbone
Francis R
FR
Heath
William R
WR
D000818:Animals; D016827:CD8 Antigens / Q000096:biosynthesis*; D002455:Cell Division / Q000276:immunology; D002469:Cell Separation; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D006561:Herpes Simplex / Q000276:immunology*; D007111:Immunity, Cellular; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007399:Interphase / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology / Q000821:virology; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000821:virology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000821:virology*; D014615:Vaccinia / Q000276:immunology*
D016827:CD8 Antigens; C431698:CD8alpha antigen