title: Risk factors for infection during a severe dengue outbreak in El Salvador in 2000.
abstract: In 2000, El Salvador experienced a large dengue-2 virus epidemic with many severe cases. A seroepidemiologic survey was conducted in 106 randomly selected households (501 residents) in an affected community (Las Pampitas). The frequency of recent infection, documented by the presence of IgM antibodies or high-titer IgG antibodies to dengue virus, was estimated to be 9.8% (95% confidence interval [CI] = 5.8-13.7), of which at least 44% were secondary infections. The number of containers positive for Aedes mosquito larvae or pupae per 100 premises (Breteau Index) was 62 and the frequency of positive premises (House Index) was 36%; 33% (35 of 106) of the informants reported having taken action against mosquito larval habitats and 82% (87 of 106) reported having taken actions against adult mosquitoes. Recent infection was associated with the presence in the home environment of mosquito infested discarded cans (odds ratio [OR] = 4.30, 95% CI = 2.54-7.28), infested discarded plastic containers (OR = 3.98, 95% CI = 1.05-15.05), and discarded tire casings (OR = 2.57, 95% CI = 1.09-6.04). The population attributable fractions associated with these factors were 4%, 13%, and 31%, respectively. Our data suggest that targeted community cleanup campaigns, particularly those directed at discarded tires and solid waste, are likely to have the greatest impact on reducing the risk of dengue infection.
authors.affiliation: Epidemic Intelligence Service, Division of Applied Public Health Training, and Division of International Health, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. jmhayes@adph.state.al.us
authors.forename: John M
authors.initials: JM
authors.lastname: Hayes
authors.forename: Enid
authors.initials: E
authors.lastname: García-Rivera
authors.forename: Roberto
authors.initials: R
authors.lastname: Flores-Reyna
authors.forename: Gloria
authors.initials: G
authors.lastname: Suárez-Rangel
authors.forename: Tito
authors.initials: T
authors.lastname: Rodríguez-Mata
authors.forename: René
authors.initials: R
authors.lastname: Coto-Portillo
authors.forename: Rafael
authors.initials: R
authors.lastname: Baltrons-Orellana
authors.forename: Elmer
authors.initials: E
authors.lastname: Mendoza-Rodríguez
authors.forename: Betry Fuentes
authors.initials: BF
authors.lastname: De Garay
authors.forename: Juan
authors.initials: J
authors.lastname: Jubis-Estrada
authors.forename: Rolando
authors.initials: R
authors.lastname: Hernández-Argueta
authors.forename: Brad J
authors.initials: BJ
authors.lastname: Biggerstaff
authors.forename: José G
authors.initials: JG
authors.lastname: Rigau-Pérez
mesh_terms: D000293:Adolescent; D000328:Adult; D000330:Aedes / Q000502:physiology; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000097:blood / Q000453:epidemiology* / Q000209:etiology / Q000635:transmission; D003716:Dengue Virus / Q000276:immunology / Q000302:isolation & purification; D004196:Disease Outbreaks; D004544:El Salvador / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007303:Insect Vectors / Q000502:physiology; D007814:Larva / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009032:Mosquito Control; D012111:Residence Characteristics; D012307:Risk Factors; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral