Quality of life should be considered the primary outcome for measuring success of endometrial ablation.
OBJECTIVE
To compare clinical and quality of life outcomes by validated instruments after endometrial ablation by four methods, and determine the primary outcome that most reflects procedure success.


METHODS
Descriptive cohort study (Canadian Task Force classification II-2).


METHODS
Minimal-access gynecologic surgery unit in northeast England.


METHODS
One hundred thirty-nine women.


METHODS
Endometrial ablation by one of four methods: Cavaterm, endometrial laser interstitial thermotherapy (ELITT), endometrial laser ablation (ELA), or NovaSure impedance-controlled system.


RESULTS
Clinical outcomes were assessed according to menstrual outcome. Whereas amenorrhea rates were significantly different among the four techniques (chi2 = 9.42, p = 0.02), combined amenorrhea and hypomenorrhea rates were not significantly different (67%, 69%, 69%, 62%, chi2 = 0.38, NS) for Cavaterm, ELITT, ELA, and NovaSure, respectively. Quality of life, measured preoperatively by the EQ-5D index and EQ-5D vas, SF-12 physical and mental component scores, and sexual activity questionnaire pleasure, habit, and discomfort scores, were substantially improved 12 months after treatment. No significant differences were seen in quality of life scores between women after endometrial ablation and the general population.


CONCLUSIONS
Quality of life for women with menorrhagia is improved to a normal level by treatment with either first- or second-generation endometrial ablation.
Abbott
Jason A
JA
Department of Endo-Gynaecology, Royal Hospital for Women, University of New South Wales, Sydney Australia.
Hawe
Jed
J
Garry
Ray
R
D015331:Cohort Studies; D004717:Endometrium / Q000601:surgery*; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D008595:Menorrhagia / Q000601:surgery / Q000628:therapy*; D017063:Outcome Assessment, Health Care; D011446:Prospective Studies; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic