Doublecortin and a tale of two serines.
Doublecortin (DCX) is a microtubule-associated protein that interacts with and regulates the microtubule cytoskeleton and is required for neuronal migration in the cortex. Two papers in this issue of Neuron (Schaar et al. and Tanaka et al.) demonstrate a role for phosphorylation in the regulation of Doublecortin. Together with recent results showing that Doublecortin may play a role regulating the morphology of migrating neurons, these findings provide new insight into the mechanisms governing neuronal migration.
LoTurco
Joseph
J
Department of Physiology and Neurobiology, University of Connecticut, Storrs, 06269, USA.
D002465:Cell Movement; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D000089622:Doublecortin Domain Proteins; D000089662:Doublecortin Protein; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000502:physiology*; D008870:Microtubules / Q000502:physiology; D009474:Neurons / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology*; D012694:Serine / Q000502:physiology*
C000714328:DCX protein, human; D000089622:Doublecortin Domain Proteins; D000089662:Doublecortin Protein; D008869:Microtubule-Associated Proteins; D009479:Neuropeptides; D012694:Serine