title: Effects of Hilsa ilisa fish oil on the atherogenic lipid profile and glycaemic status of streptozotocin-treated type 1 diabetic rats.
abstract: 1. The effects of oral administration of Hilsa (Hilsa ilisa) fish oil (1 g oil/kg bodyweight per day) on the lipid profile, platelet aggregation, anti-oxidative status and glycaemic control of streptozotocin (STZ; 90 mg/kg bodyweight)-treated type 1 diabetic rats were compared with those in fish oil-treated or untreated non-diabetic rats. 2. After 3 weeks of fish oil feeding, plasma total cholesterol decreased in both the non-diabetic and diabetic rats by 35 and approximately 10%, respectively, and triglyceride fell by 69 and 20%, respectively, compared with control rats. 3. Fish oil feeding decreased non-esterified fatty acids (NEFA) by 29% in diabetic rats but the NEFA level in non-diabetic rats was unaffected. 4. In non-diabetic and diabetic rats, platelet aggregation decreased by 49 and 37%, respectively, and total anti-oxidant status increased by 18 and 17%, respectively, after fish oil feeding. 5. Insulin levels increased by 27% in the fish oil-fed non-diabetic rats, whereas insulin levels were markedly decreased in diabetic rats. Glucose levels were not altered at all and fructosamine levels decreased by 29% only in fish oil-fed diabetic rats. 6. The results of the present study suggest that Hilsa ilisa fish oil may ameliorate the atherogenic lipid profile, platelet hyperaggregation and the anti-oxidative defence of STZ-diabetic rats and the amelioration is thought to be independent of the effects of Hilsa on glycaemic control.
authors.affiliation: Department of Food Science and Nutrition, College of Agricultural and Marine Sciences (CAMS), Sultan Qaboos University, Muscat, Oman.
authors.forename: Ishtiaq
authors.initials: I
authors.lastname: Mahmud
authors.forename: Anwar
authors.initials: A
authors.lastname: Hossain
authors.forename: Shahdat
authors.initials: S
authors.lastname: Hossain
authors.forename: Abdul
authors.initials: A
authors.lastname: Hannan
authors.forename: Liaquat
authors.initials: L
authors.lastname: Ali
authors.forename: Michio
authors.initials: M
authors.lastname: Hashimoto
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001161:Arteriosclerosis / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D008076:Cholesterol, HDL / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D005227:Fatty Acids / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005395:Fish Oils / Q000032:analysis / Q000494:pharmacology*; D005399:Fishes / Q000502:physiology*; D019270:Fructosamine / Q000097:blood; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D020318:Rats, Long-Evans; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D008076:Cholesterol, HDL; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D005395:Fish Oils; D007328:Insulin; D008055:Lipids; D014280:Triglycerides; D019270:Fructosamine