title: Insulin sensitivity in Chinese ovo-lactovegetarians compared with omnivores.
abstract: OBJECTIVE
  To compare the insulin sensitivity indices between Chinese vegetarians and omnivores.
  
  
  METHODS
  The study included 36 healthy volunteers (vegetarian, n=19; omnivore, n=17) who had normal fasting plasma glucose levels. Each participant completed an insulin suppression test. We compared steady-state plasma glucose (SSPG), fasting insulin, the homeostasis model assessment for insulin sensitivity (HOMA-IR and HOMA %S) and beta-cell function (HOMA %beta) between the groups. We also tested the correlation of SSPG with years on a vegetarian diet.
  
  
  RESULTS
  The omnivore subjects were younger than the vegetarians (55.7+/-3.7 vs 58.6+/-3.6 year of age, P=0.022). There was no difference between the two groups in sex, blood pressure, renal function tests and lipid profiles. The omnivores had higher serum uric acid levels than vegetarians (5.25+/-0.84 vs 4.54+/-0.75 mg/dl, P=0.011). The results of the indices were different between omnivores and vegetarians (SSPG (mean+/-s.d.) 105.4+/-10.2 vs 80.3+/-11.3 mg/dl, P<0.001; fasting insulin, 4.06+/-0.77 vs 3.02+/-1.19 microU/ml, P=0.004; HOMA-IR, 6.75+/-1.31 vs 4.78+/-2.07, P=0.002; HOMA %S, 159.2+/-31.7 vs 264.3+/-171.7%, P=0.018) except insulin secretion index, HOMA %beta (65.6+/-18.0 vs 58.6+/-14.8%, P=0.208). We found a clear linear relation between years on a vegetarian diet and SSPG (r=-0.541, P=0.017).
  
  
  CONCLUSIONS
  The vegetarians were more insulin sensitive than the omnivore counterparts. The degree of insulin sensitivity appeared to be correlated with years on a vegetarian diet.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, Buddhist Dalin Tzu Chi General Hospital and School of Medicine, Chia-Yi, Taiwan.
authors.forename: C-S
authors.initials: CS
authors.lastname: Kuo
authors.forename: N-S
authors.initials: NS
authors.lastname: Lai
authors.forename: L-T
authors.initials: LT
authors.lastname: Ho
authors.forename: C-L
authors.initials: CL
authors.lastname: Lin
mesh_terms: D000368:Aged; D044466:Asian People; D001786:Blood Glucose / Q000032:analysis*; D001794:Blood Pressure; D015992:Body Mass Index; D002016:Buddhism; D003611:Dairy Products / Q000032:analysis; D014676:Diet, Vegetarian; D005260:Female; D005518:Food Preferences / Q000502:physiology*; D005951:Glucose Tolerance Test; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008461:Meat Products / Q000032:analysis; D008875:Middle Aged; D013624:Taiwan; D014527:Uric Acid / Q000097:blood
chemical_list: D001786:Blood Glucose; D014527:Uric Acid