TGF-beta signaling in human skeletal and patterning disorders.
Members of the transforming growth factor beta (TGF-beta) family of multifunctional peptides are involved in almost every aspect of development. Model systems, ranging from genetically tractable invertebrates to genetically engineered mice, have been used to determine the mechanisms of TGF-beta signaling in normal development and in pathological situations. Furthermore, mutations in genes for the ligands, receptors, extracellular modulators, and intracellular signaling molecules have been associated with several human disorders. The most common are those associated with the development and maintenance of the skeletal system and axial patterning. This review focuses on the mechanisms of TGF-beta signaling with special emphasis on the molecules involved in human disorders of patterning and skeletal development.
Serra
Rosa
R
Department of Cell Biology, University of Alabama, Birmingham 35294-0005, USA. rserra@cellbio.bhs.uab.edu
Chang
Chenbei
C
D019521:Body Patterning / Q000235:genetics*; D001846:Bone Development / Q000235:genetics; D001848:Bone Diseases, Developmental / Q000235:genetics / Q000378:metabolism; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D002352:Carrier Proteins; D019902:Chondrocytes / Q000378:metabolism; D016142:Holoprosencephaly / Q000235:genetics / Q000378:metabolism; D006801:Humans; D038081:Organogenesis; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000737:chemistry / Q000378:metabolism*; D000099176:Noggin Protein
D019485:Bone Morphogenetic Proteins; D002352:Carrier Proteins; D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta; D000099176:Noggin Protein