The crystal structure of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveals a novel architecture for the bifunctional enzyme.
O'Neil
Robert H
RH
Department of Chemistry, Dartmouth College, Burke Laboratories, Hanover, NH 03755, USA.
Lilien
Ryan H
RH
Donald
Bruce R
BR
Stroud
Robert M
RM
Anderson
Amy C
AC
D000818:Animals; D002460:Cell Line; D003458:Cryptosporidium / Q000201:enzymology*; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D009097:Multienzyme Complexes / Q000737:chemistry*; D011487:Protein Conformation; D013762:Tetrahydrofolate Dehydrogenase / Q000737:chemistry*; D013940:Thymidylate Synthase / Q000737:chemistry*
D009097:Multienzyme Complexes; C056930:thymidylate synthase-dihydrofolate reductase; D013762:Tetrahydrofolate Dehydrogenase; D013940:Thymidylate Synthase