Emergence in Klebsiella pneumoniae and Enterobacter cloacae clinical isolates of the VIM-4 metallo-beta-lactamase encoded by a conjugative plasmid.
Resistance to carbapenems is an emerging problem among gram-negative hospital pathogens. A transferable plasmid encoding the VIM-4 metallo-beta-lactamase was detected in isolates of Klebsiella pneumoniae and Enterobacter cloacae obtained from a single patient under carbapenem therapy. Thus, enterobacteria appear to increasingly contribute to the spread of VIM-type enzymes.
Luzzaro
Francesco
F
Laboratorio di Microbiologia, Ospedale di Circolo, and Università dell'Insubria, I-21100 Varese, Italy.
Docquier
Jean-Denis
JD
Colinon
Céline
C
Endimiani
Andrea
A
Lombardi
Gianluigi
G
Amicosante
Gianfranco
G
Rossolini
Gian Maria
GM
Toniolo
Antonio
A
D000368:Aged; D003227:Conjugation, Genetic / Q000235:genetics*; D016972:Enterobacter cloacae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D010957:Plasmids / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics*
D001618:beta-Lactamases; C482459:metallo-beta-lactamase VIM-4, Enterobacter cloacae; C482458:metallo-beta-lactamase VIM-4, Klebsiella pneumoniae