title: NMR study of some diastereomeric nucleoside-3'-thiophosphate derivatives in solution.
abstract: The conformational properties of diastereomeric P-modified nucleotides are reported as reflected by different NMR parameters. Some conformational trends can be rationalized by consideration of the (3) J(C4',P)()and (3) J(C2',P) coupling values of the isomers and the nature of the substituent on the phosphorus. Configurational assessment of the phosphorus is inferred from NOE experiments. The effects of temperature, solvent and size of substituents are presented.
authors.affiliation: Institute of Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri ut 59-67, P.O. Box 17, 1525, Budapest, Hungary. egacs@chemres.hu
authors.forename: Eszter
authors.initials: E
authors.lastname: Gács-Baitz
authors.forename: Mária
authors.initials: M
authors.lastname: Kajtár-Peredy
authors.forename: Gyula
authors.initials: G
authors.lastname: Sági
mesh_terms: D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D009690:Nucleic Acid Conformation; D012997:Solvents; D013237:Stereoisomerism; D013696:Temperature; D013872:Thionucleosides / Q000737:chemistry*
chemical_list: D012997:Solvents; D013872:Thionucleosides