title: Repetitive transcranial magnetic stimulation of the motor cortex attenuates pain perception in complex regional pain syndrome type I.
abstract: In complex regional pain syndrome (CRPS) many clinical symptoms suggest involvement of the central nervous system. Neuropathic pain as the leading symptom is often resistant to therapy. In the present study we investigated the analgesic efficiency of repetitive transcranial magnetic simulation (rTMS) applied to the motor cortex contralateral to the CRPS-affected side. Seven out of ten patients reported decreased pain intensities. Pain relief occurred 30 s after stimulation, whereas the maximum effect was found 15 min later. Pain re-intensified increasingly 45 min after rTMS. In contrast, sham rTMS did not alter pain perception. These findings provide evidence that in CRPS I pain perception can be modulated by repetitive motor cortex stimulation.
authors.affiliation: Department of Neurology, Ruhr-University Bochum, BG-Kliniken Bergmannsheil, Buerkle-de-la-Camp-Platz 1, D-44789 Bochum, Germany. burkhard.v.pleger@ruhr-uni-bochum.de
authors.forename: Burkhard
authors.initials: B
authors.lastname: Pleger
authors.forename: Frank
authors.initials: F
authors.lastname: Janssen
authors.forename: Peter
authors.initials: P
authors.lastname: Schwenkreis
authors.forename: Birgit
authors.initials: B
authors.lastname: Völker
authors.forename: Christoph
authors.initials: C
authors.lastname: Maier
authors.forename: Martin
authors.initials: M
authors.lastname: Tegenthoff
mesh_terms: D000328:Adult; D000368:Aged; D004599:Electric Stimulation Therapy / Q000379:methods; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D010146:Pain / Q000503:physiopathology; D059408:Pain Management; D010147:Pain Measurement; D010465:Perception / Q000502:physiology; D012019:Reflex Sympathetic Dystrophy / Q000628:therapy*; D013997:Time Factors; D050781:Transcranial Magnetic Stimulation; D016896:Treatment Outcome