Tasnemoxides A-C, new cytotoxic cyclic norsesterterpene peroxides from the Red Sea sponge Diacarnus erythraenus.
Tasnemoxides A-C (1-3), three new cytotoxic cyclic norsestertepene peroxides, were isolated from the Red Sea sponge Diacarnus erythraenus, together with the known compound sigmosceptrellin B (4). The structural determination of the isolated compounds was based on extensive 1D and 2D NMR studies and mass spectral determinations. Compounds 1-3 showed moderate cytotoxicity against three cancer cell lines.
Youssef
Diaa T A
DT
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt. youssefdiaa@hotmail.com
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D019156:Indian Ocean; D051379:Mice; D015394:Molecular Structure; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D010545:Peroxides; D013729:Terpenes; C483265:tasnemoxide A; C483266:tasnemoxide B; C483267:tasnemoxide C