title: Effectiveness of bivalirudin as a replacement for heparin during cardiopulmonary bypass in patients undergoing coronary artery bypass grafting.
abstract: We investigated the use of bivalirudin as an anticoagulant therapy during cardiopulmonary bypass in 20 patients who underwent coronary artery bypass grafting. Primary end points consisted of clinical outcome data, whereas secondary end points focused on blood loss, transfusions, pharmacokinetics, and monitoring. Our data provide the first evidence of clinical feasibility of anticoagulation with bivalirudin during cardiopulmonary bypass.
authors.affiliation: Department of Anesthesia, Deutsches Herrzentrum, Berlin, Germany. Koster@dhzb.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Koster
authors.forename: Bruce
authors.initials: B
authors.lastname: Spiess
authors.forename: Derek P
authors.initials: DP
authors.lastname: Chew
authors.forename: Thomas
authors.initials: T
authors.lastname: Krabatsch
authors.forename: Luc
authors.initials: L
authors.lastname: Tambeur
authors.forename: Abe
authors.initials: A
authors.lastname: DeAnda
authors.forename: Roland
authors.initials: R
authors.lastname: Hetzer
authors.forename: Hermann
authors.initials: H
authors.lastname: Kuppe
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Smedira
authors.forename: A Michael
authors.initials: AM
authors.lastname: Lincoff
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass / Q000379:methods*; D001026:Coronary Artery Bypass; D005260:Female; D005343:Fibrinolytic Agents / Q000097:blood / Q000494:pharmacology*; D006629:Hirudins / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D010446:Peptide Fragments / Q000097:blood / Q000494:pharmacology*; D010865:Pilot Projects; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000097:blood / Q000494:pharmacology*
chemical_list: D005343:Fibrinolytic Agents; D006629:Hirudins; D010446:Peptide Fragments; D011994:Recombinant Proteins; C074619:bivalirudin