Isotamarixen - a new antioxidant and prolyl endopeptidase-inhibiting triterpenoid from Tamarix hispida.
A new pentacyclic triterpenoid, 3alpha-(3",4"-dihydroxy- trans-cinnamoyloxy)- D-friedoolean-14-en-28-oic acid ( 1) has been isolated along with two known compounds, rhamnocitrin ( 2) and isorhamnetin ( 3) from the aerial parts of Tamarix hispida Willd. Compound 1 was found to be a potent antioxidant. In addition, compounds 1 - 3 showed significant inhibitory activity against prolylendopeptidase (PEP).
Sultanova
Nurgul
N
HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan.
Makhmoor
Talat
T
Yasin
Amsha
A
Abilov
Z A
ZA
Omurkamzinova
V B
VB
Atta-ur-Rahman
Choudhary
M Iqbal
MI
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D035261:Plant Components, Aerial; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000187:drug effects*; D032363:Tamaricaceae; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
D000975:Antioxidants; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; C483063:Isotamarixen; D010851:Picrates; D014315:Triterpenes; C004931:1,1-diphenyl-2-picrylhydrazyl; D012697:Serine Endopeptidases; C000705287:PREPL protein, human; D000085822:Prolyl Oligopeptidases