[Peptide correction of age-related pineal disturbances in monkeys].
Investigation of the age-related changes of the pineal gland function and possible ways for their overcoming on nonhuman monkey model was the purpose of this study. Hormonal function of the pineal gland was studied in 38 Macaca mulatta females of two age groups: 6-8 years old, n = 18 and 20-26 years old, n = 20. Pineal function was studied in basal conditions and after administration of pineal peptide preparations--epithalamin and epitalon, both developed in the St. Petersburg Institute of Bioregulation and Gerontology (Russia). It has been revealed that plasma melatonin concentration in monkeys has well expressed high amplitude diurnal rhythm. Minimum is manifested at 4 p.m. and maximum--at 10 p.m.-3 a.m. In aging the mean diurnal melatonin concentration decreases by 1.5-2 times as well as in different points of the day: 9 p.m., 10 p.m., 3 a.m. and 4 a.m. Administration of pineal peptides--epithalamin (at the dose 5 mg/animal/day intramuscularly during 10 consecutive days) or epitalon (at the dose 10 micrograms/animal/day intramuscularly during 7-10 consecutive days) induced significant increase in the night plasma melatonin in old monkeys, but the treatment did not change the melatonin level in young monkeys. Taking into consideration that melatonin is very important for regulation of the diurnal rhythm of functioning of some organs and systems it should be suggested that applying epithalamin and epitalon are perspective in the correction of age-related hormonal imbalance and age pathology.
Goncharova
N D
ND
Institute of Medical Primatology, Russian Academy of Medical Sciences, Veseloye 1, Sochi-Adler, 354376, Russia.
Vengerin
A A
AA
Shmaliĭ
A V
AV
Khavinson
V Kh
VKh
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002940:Circadian Rhythm; D005260:Female; D007273:Injections, Intramuscular; D008253:Macaca mulatta; D008550:Melatonin / Q000097:blood / Q000378:metabolism*; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D010870:Pineal Gland / Q000187:drug effects* / Q000378:metabolism
D009842:Oligopeptides; D010455:Peptides; C027437:epithalamin; D008550:Melatonin; C421253:alanyl-glutamyl-aspartyl-glycine