[Detection of hepatitis E virus on a blood donor and its infectivity to rhesus monkey].
OBJECTIVE
To understand the infectivity and pathogenicity of the plasma of hepatitis E virus (HEV) viremia to primate animals.


METHODS
RNA fragment of HEV genotype IV was detected on one healthy donor who was positive for anti-HEV IgM and negative for anti-HEV IgG. Then 10 ml plasma from above donor was transfused to rhesus monkey to observe its infectivity and pathogenicity.


RESULTS
Acute hepatitis E was developed in rhesus monkey who accept HEV RNA positive plasma. It was confirmed by virological, immunological, biochemical and histopathological data.


CONCLUSIONS
Acute hepatitis E can be induced by plasma transfusion of HEV viremia, which indicate the possibility of transfusion transmitted hepatitis E
Xia
Ning-shao
NS
The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen University, Xiamen 361005, China.
Zhang
Jun
J
Zheng
Ying-jie
YJ
Qiu
Yan
Y
Ge
Sheng-xiang
SX
Ye
Xiang-zhong
XZ
Ou
Shan-hai
SH
D000208:Acute Disease; D000818:Animals; D001782:Blood Donors; D016751:Hepatitis E / Q000635:transmission*; D016752:Hepatitis E virus / Q000302:isolation & purification*; D006801:Humans; D008253:Macaca mulatta; D012367:RNA, Viral / Q000097:blood; D065227:Transfusion Reaction
D012367:RNA, Viral