title: Prolonged mechanical support of the left ventricle.
abstract: An interdisciplinary group has developed a left ventricular assist pump system composed of a modified sac type pump, a pneumatic power unit, and a synchronizer. The pump fills from the left ventricle and discharges into the aorta. The system was employed for left ventricular assistance in a series of 12 normal calves, with an average pumping period of 70 +/- 8 days. The system was then evaluated in a series of calves in whom profound left ventricular failure had been produced. These studies indicate that the assist pump is effective in supporting the circulation and completely unloading the left ventricle. The assist system has now been employed in four patients who could not be weaned from cardiopulmonary bypass following cardiac valve replacement. The assist pump supported the circulation in three instances. In one patient, the assist pump was employed for 8 days until left ventricular function had improved sufficiently to permit pump removal; the patient was subsequently discharged from the hospital.
authors.affiliation: Department of Surgery, College of Medicine, The Milton S. Hershey Medical Center, The Pennsylvania State University, 500 University Drive, Hershey, Pennsylvania 17033, USA.
authors.forename: W S
authors.initials: WS
authors.lastname: Pierce
authors.forename: J H
authors.initials: JH
authors.lastname: Donachy
authors.forename: D L
authors.initials: DL
authors.lastname: Landis
authors.forename: J A
authors.initials: JA
authors.lastname: Brighton
authors.forename: G
authors.initials: G
authors.lastname: Rosenberg
authors.forename: J J
authors.initials: JJ
authors.lastname: Migliore
authors.forename: G A
authors.initials: GA
authors.lastname: Prophet
authors.forename: W J
authors.initials: WJ
authors.lastname: White
authors.forename: J A
authors.initials: JA
authors.lastname: Waldhausen
mesh_terms: D000368:Aged; D000818:Animals; D002417:Cattle; D004867:Equipment Design; D017809:Fatal Outcome; D005260:Female; D006353:Heart-Assist Devices; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery / Q000637:transplantation; D008946:Mitral Valve Stenosis / Q000601:surgery; D023421:Models, Animal; D013552:Swine; D013997:Time Factors; D014183:Transplantation, Heterologous; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000601:surgery*
chemical_list: D006454:Hemoglobins