title: Comparison of survival and other complications after heart transplantation in patients taking amiodarone before surgery versus those not taking amiodarone.
abstract: Concern exists regarding preoperative amiodarone use and complications occurring after heart transplantation (HT). During a 10-year period of performing HT, we found that patients treated with amiodarone before undergoing HT had decreased overall survival, required longer periods of ventilatory support, and were at increased risk for significant bleeding complications. These findings raise further concern about the use of amiodarone treatment in patients with heart failure before undergoing HT.
authors.affiliation: Division of Cardiology, Tufts University Medical School, Tufts-New England Medical Center, Boston, Massachusetts, USA.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Blomberg
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Feingold
authors.forename: David
authors.initials: D
authors.lastname: Denofrio
authors.forename: William
authors.initials: W
authors.lastname: Rand
authors.forename: Marvin A
authors.initials: MA
authors.lastname: Konstam
authors.forename: N A Mark
authors.initials: NA
authors.lastname: Estes
authors.forename: Mark S
authors.initials: MS
authors.lastname: Link
mesh_terms: D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D005260:Female; D006333:Heart Failure / Q000401:mortality* / Q000628:therapy*; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D015996:Survival Rate; D014665:Vasodilator Agents / Q000009:adverse effects*
chemical_list: D014665:Vasodilator Agents; D000638:Amiodarone