A case of radiation recall mucositis associated with docetaxel.
BACKGROUND
Radiation recall reactions, in particular dermatitis, are well documented in the literature. However, radiation recall mucositis is a rare clinical phenomenon.


METHODS
We report a case of a 45-year-old man diagnosed with squamous cell carcinoma of the base of tongue. He was treated with surgery followed by chemotherapy and radiation therapy. Several months after completing treatment, he had a recurrence develop outside of the previously irradiated field. He was offered radiation therapy concurrent with docetaxel as salvage therapy.


RESULTS
During salvage therapy, acute recall mucositis developed corresponding to his previously irradiated fields. His chemotherapy with docetaxel was withheld, and his symptoms rapidly improved.


CONCLUSIONS
This case describes radiation recall mucositis associated with docetaxel, a rare but potentially serious clinical situation. Given the potential severity of the reaction and increasing use of docetaxel as second-line treatment of recurrent head and neck cancers, it is important to be aware of this phenomenon.
Culp
Laura R
LR
Department of Radiation Oncology, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555-0711, USA. lrculp@utmb.edu
Pou
Anna M
AM
Jones
Dennie V
DV
Bayouth
John
J
Sanguineti
Giuseppe
G
D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D000077143:Docetaxel; D006801:Humans; D007249:Inflammation / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000187:drug effects* / Q000473:pathology / Q000528:radiation effects; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D011838:Radiation-Sensitizing Agents / Q000009:adverse effects*; D011855:Radiodermatitis / Q000209:etiology*; D018714:Radiotherapy, Adjuvant; D043823:Taxoids / Q000009:adverse effects*; D014062:Tongue Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery*
D000972:Antineoplastic Agents, Phytogenic; D011838:Radiation-Sensitizing Agents; D043823:Taxoids; D000077143:Docetaxel