Phenylpropanoid glycosides from Orobanche caerulescens.
Two new phenylpropanoid glycosides, caerulescenoside ( 1), and 3'-methyl crenatoside ( 2), as well as five known phenylpropanoid glycosides [acteoside ( 3), isoacteoside ( 4), campneoside II ( 5), crenatoside ( 6), and desrhamnosyl acteoside ( 7)] were isolated from the whole plant of Orobanche caerulescens. The antioxidative effects of compounds 1 - 7 on human low-density lipoprotein were evaluated. All these compounds suppress concentration-dependently conjugated diene formation with IC (50) values of 1.25 +/- 0.06, 2.97 +/- 0.31, 0.31 +/- 0.01, 1.01 +/- 0.05, 1.15 +/- 0.04, 1.69 +/- 0.15, and 0.64 +/- 0.03 microM, respectively. Comparison of their antioxidative activities with that of resveratrol (IC (50) : 6.75 +/- 1.05 microM), a natural phenolic antioxidant isolated from grape, demonstrated that the prolonged effect on lag-time and the damping effect on oxidative rate by compounds 1 - 7 were all more potent.
Lin
Lie-Chwen
LC
National Research Institute of Chinese Medicine, Taipei, Taiwan, ROC. lclin@cma23.nricm.edu.tw
Chiou
Wen-Fei
WF
Chou
Cheng-Jen
CJ
D000328:Adult; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects*; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D031672:Orobanche; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology; D059808:Polyphenols
D000975:Antioxidants; D008078:Cholesterol, LDL; D005960:Glucosides; D006027:Glycosides; D010636:Phenols; D010936:Plant Extracts; D000077185:Resveratrol; D013267:Stilbenes; C058956:acteoside; D059808:Polyphenols