Safety and efficacy of antimicrobial peptides against naturally acquired leishmaniasis.
Leishmaniases, which are important causes of morbidity and mortality in humans and dogs, are extremely difficult to treat. Antimicrobial peptides are rarely used as alternative treatments for naturally acquired parasitic diseases. Here we report that the acylated synthetic antimicrobial peptide Oct-CA(1-7)M(2-9) is safe and effective for treating naturally acquired canine leishmaniasis.
Alberola
J
J
Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, 08193 Bellaterra, Barcelona, Spain. Jordi.Alberola@uab.es
Rodríguez
A
A
Francino
O
O
Roura
X
X
Rivas
L
L
Andreu
D
D
D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D023181:Antimicrobial Cationic Peptides / Q000009:adverse effects / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000469:parasitology; D004285:Dogs; D018314:Leishmania infantum; D007898:Leishmaniasis, Visceral / Q000188:drug therapy* / Q000469:parasitology / Q000662:veterinary*
D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; C482457:octyl-cecropin(1-7)melittin(2-9)