title: Effect of intra-arterial cisplatin on multiple liver metastases from rectal cancer associated with ulcerative colitis.
abstract: We report a patient with synchronous multiple liver metastases from rectal cancer associated with ulcerative colitis. Because the liver tumors were unresectable, we performed total proctocolectomy and hepatic intra-arterial cisplatin infusion with systemic oral administration of fluorouracil. A complete response was obtained. The patient is alive without sign of recurrence 5 years postoperatively. Hepatic intra-arterial administration of cisplatin should be considered in the treatment of unresectable liver metastases from colorectal cancer.
authors.affiliation: Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan. cshibata@gonryo.med.tohoku.ac.jp
authors.forename: Chikashi
authors.initials: C
authors.lastname: Shibata
authors.forename: Xue-Lin
authors.initials: XL
authors.lastname: Jin
authors.forename: Yuji
authors.initials: Y
authors.lastname: Funayama
authors.forename: Kouhei
authors.initials: K
authors.lastname: Fukushima
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Hashimoto
authors.forename: Munenori
authors.initials: M
authors.lastname: Nagao
authors.forename: Sho
authors.initials: S
authors.lastname: Haneda
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Seiki
authors.initials: S
authors.lastname: Matsuno
authors.forename: Iwao
authors.initials: I
authors.lastname: Sasaki
authors.forename: Hiroo
authors.initials: H
authors.lastname: Naito
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology*; D003093:Colitis, Ulcerative / Q000503:physiopathology; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin