Ribosomal alterations contribute to bacterial resistance against the dipeptide antibiotic TAN 1057.
TAN 1057-resistant Staphylococcus aureus and Escherichia coli strains were selected to elucidate the mechanism of resistance and the mode of action of this dipeptide antibiotic. Cell-free translation with isolated ribosomes and S150 fractions from sensitive and resistant S. aureus strains demonstrated that alterations in the ribosomes contribute to the resistance of the bacteria.
Limburg
E
E
Department of Antiinfectives, Pharma Research, Bayer Health Care AG, D-42096 Wuppertal, Germany.
Gahlmann
R
R
Kroll
H-P
HP
Beyer
D
D
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000187:drug effects* / Q000235:genetics*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics*
D000900:Anti-Bacterial Agents; D004151:Dipeptides; C081415:TAN 1057A; D004917:Erythromycin