A novel antioxidant action of ethanolamine plasmalogens in lowering the oxidizability of membranes.
We have demonstrated a novel antioxidant action of ethanolamine plasmalogens both in protecting cholesterol from oxidation by free radicals and in lowering the oxidizability of membranes, along with the action of scavenging radicals, by the oxygen-uptake method using large unilamellar vesicles and the water-soluble azo-radical initiator, AAPH [2,2'-azobis-(2-amidino-propane) dihydrochloride].
Maeba
R
R
Department of Biochemistry, Teikyo University School of Medicine, Itabashi-Ku, Tokyo 173-8605, Japan. maeba@med.teikyo-u.ac.jp
Ueta
N
N
D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects* / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D010955:Plasmalogens / Q000378:metabolism / Q000494:pharmacology*; D024502:alpha-Tocopherol / Q000494:pharmacology
D000975:Antioxidants; D010955:Plasmalogens; C020791:phosphatidal ethanolamines; D002784:Cholesterol; D024502:alpha-Tocopherol