Can the principles of evidence-based medicine be applied to the treatment of aortic dissections?
Surgical treatment of patients with acute type A aortic dissections has improved early survival from 10-20 to approximately 80%. Data supporting several other treatment recommendations in patients with aortic dissection, however, are less convincing. We hypothesized that applying strict principles of evidence-based medicine would invalidate most of the recommendations in these published papers. We conducted a literature search asking three questions: (1) Is the use of routine circulatory arrest and an 'open distal' anastomosis technique better than traditional aortic cross clamping? (2) Does a persistent false lumen in the distal aorta wall have an adverse influence on long-term event-free survival? and (3) Is primary surgical or medical treatment of patients with Stanford acute type B dissections preferable in terms of long-term event-free survival? We searched Entrez Pubmed (National Library of Medicine) for all papers on these topics from 1980 to January 2003. Screening 3164 papers identified using the search terms 'aortic dissection' and 'treatment' yielded 15 papers fulfilling a set of a priori inclusion criteria. No study had a design that allowed unequivocal conclusions; moreover, the heterogeneity in study design and patient populations precluded formal meta-analysis. The difficulties inherent in conducting stringent clinical studies addressing various treatment strategies for patients with aortic dissection hamper their quality and weaken their recommendations for different treatment options. Specifically, no conclusive evidence exists favoring use of an open distal anastomosis in patients with acute type A dissections or complete elimination of flow in the distal aortic false lumen; similarly, medical therapy of patients with acute type B aortic dissections has no proven advantage over surgical treatment.
Myrmel
Truls
T
Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA. truls.myrmel@unn.no
Lai
David T M
DT
Miller
D Craig
DC
D000208:Acute Disease; D000784:Aortic Dissection / Q000188:drug therapy / Q000601:surgery*; D001014:Aortic Aneurysm / Q000188:drug therapy / Q000601:surgery*; D006348:Cardiac Surgical Procedures / Q000379:methods; D019317:Evidence-Based Medicine; D006801:Humans; D012107:Research Design