Nogo 3'-untranslated region CAA insertion: failure to replicate association with schizophrenia and demonstration of marked population difference in frequency of the insertion.
Novak et al. [Brain Res. Mol. Brain Res. 107 (2002) 183] reported that a CAA insertion in the 3'-untranslated region of the Nogo gene was associated with schizophrenia. We examined the frequency of this CAA insertion in 57 European American subjects with schizophrenia and 243 controls, and in a smaller group of African American subjects (N=72; 20 with schizophrenia). We found a similar frequency of the CAA insertion for patients and controls in both populations, but a large difference in CAA insertion frequency between the two racial groups.
Covault
Jonathan
J
Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030-2103, USA. covault@psychiatry.uchc.edu
Lee
Jessica
J
Jensen
Kevin
K
Kranzler
Henry
H
D001741:Black or African American; D016009:Chi-Square Distribution; D004251:DNA Transposable Elements / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D009185:Myelin Proteins / Q000235:genetics* / Q000378:metabolism; D000070798:Nogo Proteins; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D020506:Untranslated Regions
D004251:DNA Transposable Elements; D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603199:RTN4 protein, human; D020506:Untranslated Regions