title: The influence of diabetes mellitus and insulin therapy on biomechanical retention around dental implants: a study in rabbits.
abstract: The oral rehabilitation by dental implants in patients with diabetes remains a controversial issue. The aim of this study was to evaluate the influence of diabetes mellitus and insulin therapy on the bone healing around dental implants using torque removal. Twenty-seven rabbits were randomly divided into 3 groups with 9 animals each: control (C) group, induced diabetic (D) group, and insulin-treated diabetic (ITD) group (10 U/day). After 1 week, one implant was inserted at the tibial metaphysis of the animals. The glucose levels were periodically evaluated through the glucose-oxidase enzymatic method. The animals were killed at 4, 8, and 12 weeks after surgery and the biomechanical test was performed using a torque manometer. Statistically significant differences regarding the removal torque of the implant could not be found at 4 weeks (P = 0.2) among groups. Group C showed statistically higher values than groups D and ITD at the experimental periods of 8 (P = 0.0001 and P = 0.0002, respectively) and 12 weeks (P = 0.0053 and P = 0.001, respectively). There were no statistical differences between D and ITD groups in any of the experimental periods. Diabetes mellitus has negatively influenced the mechanical retention of implants placed at the tibial metaphysis of rabbits. Therapy with insulin did not induce any changes.
authors.affiliation: Department of Diagnostic and Surgery, Division of Periodontology, School of Dentistry at Araraquara, State University of São Paulo (UNESP), Araraquara, São Paulo, Brazil.
authors.forename: Rogério
authors.initials: R
authors.lastname: Margonar
authors.forename: Celso E
authors.initials: CE
authors.lastname: Sakakura
authors.forename: Marinella
authors.initials: M
authors.lastname: Holzhausen
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Pepato
authors.forename: júnior Rodolfo Cândia
authors.initials: jR
authors.lastname: Alba
authors.forename: júnior Elcio
authors.initials: jE
authors.lastname: Marcantonio
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001696:Biomechanical Phenomena; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D020878:Device Removal; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D020007:Implants, Experimental; D007328:Insulin / Q000627:therapeutic use*; D016348:Osseointegration; D011817:Rabbits; D018709:Statistics, Nonparametric; D013977:Tibia; D013997:Time Factors; D019415:Torque
chemical_list: D015921:Dental Implants; D007328:Insulin