title: Geranyl N-dimethylallylanthranilate, a new compound from Esenbeckia yaaxhokob.
abstract: Through a bioactivity-guided fractionation from the acetone extract of the leaves from Esenbeckia yaaxhokob geranyl N-dimethylallylanthranilate ( 1), the first natural N- and O-prenylated anthranilate, was isolated in addition of the known natural products caryophyllene beta-oxide, caryolane-5beta,9beta-diol, spathulenol ( 2), friedeline, friedelanol, decaprenol, flindersiamine ( 3) and  beta-sitosterol. The antimicrobial activities of the extract, fractions and pure compounds were evaluated against two Gram (+) and four Gram (-) bacteria. Compounds 1 and 2 exhibited moderated antimicrobial activity against Staphyloccocus aureus, while 3 was active against S. aureus and Streptococcus faecalis.
authors.affiliation: Centro de Investigaciones Químicas de la Universidad Autónoma del Estado de Morelos, Chamilpa, Cuernavaca, Mor., México.
authors.forename: A Berenice
authors.initials: AB
authors.lastname: Aguilar-Guadarrama
authors.forename: María Yolanda
authors.initials: MY
authors.lastname: Rios
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008519:Medicine, Traditional; D008800:Mexico; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D010946:Plants, Medicinal; D062367:ortho-Aminobenzoates / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts; C483069:geranyl N-dimethylallylanthranilate; D062367:ortho-Aminobenzoates