title: [A case of effective weekly paclitaxel administration for primary lesion of schirrous gastric cancer].
abstract: We report a case of advanced schirrous gastric cancer with carcinomatous peritonitis. Chemotherapy with TS-1 was applied during the first 4 weeks, but the tumor did not respond to this therapy. Next, paclitaxel (TXL) was administered at a weekly dose of 90 mg/body/day for 3 weeks followed by a week interval of rest. Remarkable mass reduction of primary tumor was observed after 3 courses of treatment, and the symptom derived from primary tumor was relieved without significant side effects. The clinical course for schirrous gastric cancer with carcinomatous peritonitis is still miserable for patients, although many attempts have been made to improve its prognosis. A weekly paclitaxel regimen appears to be one of the promising treatment for schirrous gastric cancer.
authors.affiliation: Dept. of Gastroenterology, Kyoto Katsura Hospital.
authors.forename: Mitsunari
authors.initials: M
authors.lastname: Ogasawara
authors.forename: Masashi
authors.initials: M
authors.lastname: Kanai
authors.forename: Eiji
authors.initials: E
authors.lastname: Tada
authors.forename: Keisuke
authors.initials: K
authors.lastname: Oe
authors.forename: Akihiko
authors.initials: A
authors.lastname: Hamada
authors.forename: Youko
authors.initials: Y
authors.lastname: Endo
authors.forename: Masashi
authors.initials: M
authors.lastname: Yamakawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Takeda
authors.forename: Ayao
authors.initials: A
authors.lastname: Torii
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hikita
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsubayashi
authors.forename: Haruhiro
authors.initials: H
authors.lastname: Nishikawa
authors.forename: Jiro
authors.initials: J
authors.lastname: Ochi
authors.forename: Kensuke
authors.initials: K
authors.lastname: Miura
mesh_terms: D002293:Adenocarcinoma, Scirrhous / Q000188:drug therapy* / Q000556:secondary; D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D017239:Paclitaxel / Q000008:administration & dosage*; D010534:Peritoneal Neoplasms / Q000556:secondary; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel