title: Major liver resections for hepatocellular carcinoma on cirrhosis: early and long-term outcomes.
abstract: Since the lack of donors, liver resections continue to be the treatment of choice for cirrhotic patients with good liver function and resectable hepatocellular carcinoma (HCC). Moreover, over the past 2 decades, an increasing number of major hepatic resections have been performed. The aim of this study is to evaluate short- and long-term outcomes of 55 cirrhotic patients undergoing major hepatic resection with particular attention to the survival of the patients with gross portal vein invasion or large size tumors. Twenty-two patients (40%) required intra- or post-operative blood transfusion. Medium tumor size was 66.6 +/- 29.2 mm; 7 patients had large size (>10 cm) HCCs. A single node was present in 38 cases (69.1%). There was a gross portal vein tumor thrombus (PVTT) in 13 patients (23.6%). Resection was non-curative in 4 cases. In-hospital mortality and morbidity rates were 5.5% and 30.9%, respectively. The overall and disease-free survival rates were 36.2% and 42.8%, respectively. Overall 5-year survival rates of patients with large size tumors was 17.1%. Ten patients with a gross PVTT had an R0 resection with a 26.6% 5-year survival rate. In conclusion, major hepatic resections for HCC can be performed with low mortality and morbidity rates. HCCs with PVTT or greater than 10 cm in size have very limited options of treatment; the favorable long-term results of our study suggest that they should undergo surgery if a radical resection can be achieved.
authors.affiliation: Department of Surgical Oncology, Istituto per la Ricerca e la Cura del Cancro, Turin, Italy. lcapussotti@mauriziano.it
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Capussotti
authors.forename: Andrea
authors.initials: A
authors.lastname: Muratore
authors.forename: Paolo
authors.initials: P
authors.lastname: Massucco
authors.forename: Alessandro
authors.initials: A
authors.lastname: Ferrero
authors.forename: Roberto
authors.initials: R
authors.lastname: Polastri
authors.forename: Hedayat
authors.initials: H
authors.lastname: Bouzari
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000150:complications* / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008113:Liver Neoplasms / Q000098:blood supply / Q000150:complications* / Q000401:mortality / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000209:etiology