title: Exposure to concentrated ambient particles (CAPs): a review.
abstract: Epidemiologic studies support a participation of fine particulate matter (PM) with a diameter of 0.1 to 2.5 microm in the effects of air pollution particles on human health. The ambient fine particle concentrator is a recently developed technology that can enrich the mass of ambient fine particles in real time with little modification. The advantages of concentrators are that the particles produced are "real world" and they allow exposure at pertinent masses. Limitations include variability in both particle mass and composition and some uncertainty over the best statistical approach to analyze the data. Cumulative evidence provided by the body of initial investigation shows that exposures to concentrated ambient particles (CAPs) can be accomplished safely in both humans and animals. Human investigation using the CAPs has shown acute lung inflammation and changes in both blood indices and heart rate variability. Animal studies support a potential pulmonary inflammation, blood changes, alterations of specific cardiac endpoints, and an increased susceptibility of specific models. These studies have helped establish the causal relationship between find particle exposure and adverse health effects in the lung and cardiovascular system. In addition, it appears that specific components in CAPS may differentially affect these tissues.
authors.affiliation: Clinical Research Branch, Human Studies Division, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA. ghio.andy@epa.gov
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Ghio
authors.forename: Yuh-Chin T
authors.initials: YC
authors.lastname: Huang
mesh_terms: D000393:Air Pollutants / Q000737:chemistry / Q000633:toxicity*; D000397:Air Pollution / Q000009:adverse effects* / Q000032:analysis; D000818:Animals; D001273:Atmosphere Exposure Chambers; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004781:Environmental Exposure / Q000009:adverse effects; D006801:Humans; D012107:Research Design
chemical_list: D000393:Air Pollutants