title: Discordance between exercise SPECT lung Tl-201 uptake and left ventricular transient ischemic dilation in patients with CAD.
abstract: BACKGROUND
  In patients with coronary artery disease (CAD), the characteristics of those with discordant exercise thallium 201 single photon emission computed tomography (SPECT) lung uptake (lung-to-heart [L/H] ratio) and left ventricular (LV) transient ischemic dilation (LVTID) are not well defined.
  
  
  RESULTS
  The population included 310 patients having exercise Tl-201 SPECT and coronary angiography. The population was subclassified into 4 subgroups: increased L/H ratio only, increased LVTID only, both, and neither. The L/H ratio was weakly correlated to LVTID (r = 0.18). The L/H ratio was correlated to the summed difference score (r = 0.26), summed rest score (r = 0.31), summed stress score (r = 0.5), and rest and stress LV volume (r = 0.5 and r = 0.54, respectively). LVTID was only correlated to the summed difference score (r = 0.32) and stress LV volume (r = 0.17). Increased LVTID only was associated with more frequent ischemia and patients with it tended to be more extensively ischemic, as compared with patients with increased L/H ratio only, but had a similar angiographic extent of CAD. These results were independent of prior myocardial infarction variable.
  
  
  CONCLUSIONS
  As compared with patients with increased L/H ratio alone, patients with increased LVTID alone are more frequently ischemic but have a similar angiographic extent of CAD. Increased L/H ratio was correlated to both rest and postexercise LV volume, whereas increased LVTID was correlated only to postexercise LV volume.
authors.affiliation: Department of Nuclear Medicine, Lariboisière University Hospital, AP-HP, Paris, France. doumit.daou@lrb.ap-hop-paris.fr
authors.forename: Doumit
authors.initials: D
authors.lastname: Daou
authors.forename: Carlos
authors.initials: C
authors.lastname: Coaguila
authors.forename: Nicolas
authors.initials: N
authors.lastname: Delahaye
authors.forename: François
authors.initials: F
authors.lastname: Houzet
authors.forename: Rachida
authors.initials: R
authors.lastname: Lebtahi
authors.forename: Dominique
authors.initials: D
authors.lastname: Le Guludec
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005080:Exercise Test; D005260:Female; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D013794:Thallium Radioisotopes / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D013794:Thallium Radioisotopes