title: Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells.
abstract: Regulatory T cells (Tregs) fulfill a central role in immune regulation. We reported previously that the integrin alphaEbeta7 discriminates distinct subsets of murine CD4+ regulatory T cells. Use of this marker has now helped to unravel a fundamental dichotomy among regulatory T cells. alphaE-CD25+ cells expressed L-selectin and CCR7, enabling recirculation through lymphoid tissues. In contrast, alphaE -positive subsets (CD25+ and CD25-) displayed an effector/memory phenotype expressing high levels of E/P-selectin-binding ligands, multiple adhesion molecules as well as receptors for inflammatory chemokines, allowing efficient migration into inflamed sites. Accordingly, alphaE -expressing cells were found to be the most potent suppressors of inflammatory processes in disease models such as antigen-induced arthritis.
authors.affiliation: Experimentelle Rheumatologie, Medizinische Klinik, Charité, Humboldt-Universitaet, Schumannstr. 21/22, 10117 Berlin, Germany. Huehn@drfz.de
authors.forename: Jochen
authors.initials: J
authors.lastname: Huehn
authors.forename: Kerstin
authors.initials: K
authors.lastname: Siegmund
authors.forename: Joachim C U
authors.initials: JC
authors.lastname: Lehmann
authors.forename: Christiane
authors.initials: C
authors.lastname: Siewert
authors.forename: Uta
authors.initials: U
authors.lastname: Haubold
authors.forename: Markus
authors.initials: M
authors.lastname: Feuerer
authors.forename: Gudrun F
authors.initials: GF
authors.lastname: Debes
authors.forename: Joerg
authors.initials: J
authors.lastname: Lauber
authors.forename: Oliver
authors.initials: O
authors.lastname: Frey
authors.forename: Grzegorz K
authors.initials: GK
authors.lastname: Przybylski
authors.forename: Uwe
authors.initials: U
authors.lastname: Niesner
authors.forename: Maurus
authors.initials: M
authors.lastname: de la Rosa
authors.forename: Christian A
authors.initials: CA
authors.lastname: Schmidt
authors.forename: Rolf
authors.initials: R
authors.lastname: Bräuer
authors.forename: Jan
authors.initials: J
authors.lastname: Buer
authors.forename: Alexander
authors.initials: A
authors.lastname: Scheffold
authors.forename: Alf
authors.initials: A
authors.lastname: Hamann
mesh_terms: D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology; D015704:CD4 Antigens / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D007156:Immunologic Memory / Q000276:immunology*; D016130:Immunophenotyping; D007249:Inflammation / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D020411:Oligonucleotide Array Sequence Analysis; D015375:Receptors, Interleukin-2 / Q000276:immunology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D015704:CD4 Antigens; D015375:Receptors, Interleukin-2