[A study on biomarkers of styrene].
OBJECTIVE
To study the biomarkers of styrene and to provide theoretical basis for bio-monitoring of styrene.


METHODS
Urinary mandalic acid (MA), phenylglyoxalic acid (PGA) and mercapturic acid (MUA) of styrene were examined by high performance liquid chromatography (HPLC).


RESULTS
The correlation regression equations between exposure dose and MA, PGA and MUA level in morning urinary samples were: ŷ = 2.58x + 70.82; ŷ = 1.66x + 37.42; ŷ = 0.05x + 0.55 respectively. The correlation regression equations between exposure dose and MA, PGA and MUA level in post-shift urinary samples were: ŷ = 1.85x + 89.02; ŷ = 1.33x + 4.32; ŷ = 0.04x + 0.68 respectively. All showed close dose-response relationship.


CONCLUSIONS
The level of MA, PGA and MUA in morning or post-shift urinary samples may be used as bio-monitoring indexes of styrene.
Shao
Hua
H
Shandong Institute of Labor Health and Occupational Disease, Jinan, Shandon 250062, China.
Wang
Xiao-yun
XY
Cheng
Hu
H
Shi
Yi-kang
YK
Zhang
Meng-ping
MP
D000111:Acetylcysteine / Q000652:urine*; D000328:Adult; D015415:Biomarkers; D002851:Chromatography, High Pressure Liquid; D004784:Environmental Monitoring; D006038:Glyoxylates / Q000652:urine*; D006801:Humans; D008297:Male; D008333:Mandelic Acids / Q000652:urine*; D012044:Regression Analysis; D020058:Styrene / Q000378:metabolism*
D015415:Biomarkers; D006038:Glyoxylates; D008333:Mandelic Acids; C012482:phenylglyoxylic acid; D020058:Styrene; D000111:Acetylcysteine