title: [Biological behavior of cardial cancer and its effect on surgical management].
abstract: OBJECTIVE
  To study the biological behavior of cardial cancer and its influence on surgical management.
  
  
  METHODS
  Complete clinicopathologic data of 46 cases with cardial cancer undergoing radical gastrectomy was investigated retrospectively. The relationships between tumor Borrmann type, depth of invasion, growth pattern, lymph node metastasis and 5-year survival rate postoperative were analyzed.
  
  
  RESULTS
  Of 46 cases, Borrmann type III, Type IV and Type II was 76% (35/46), 18% (8/46) and 6% (3/46) respectively; 5-year survival rate was 40% (14/35), 0 (0/8) and 100% (3/3) respectively. In respect of the depth of invasion, pT(2) was 31% (14/46) cases with 71% (10/14) lymph node metastasis; and 5-year survival rate was 64% (9/14). pT(3) was 15% (7/46) cases with 86% (6/7) lymph node metastasis; and 5-year survival rate was 57% (4/7). And pT(4) was 54% (25/46) cases with 92% (23/25) lymph node metastasis; and 5-year survival rate was 12% (3/25). The growth pattern in 87% (40/46) cases was infiltrative; and 5-year survival rate was 28% (11/40); the growth pattern in 13% (6/46) cases was expansive; and 5-year survival rate was 100% (6/6).
  
  
  CONCLUSIONS
  D(2)(+) radical total gastrectomy should be performed on the developed cardial cancer, and if necessary, resection of body and tail of pancreas should be chosen.
authors.affiliation: Department of General Surgery, Zhejiang Provence People's Hospital, Hangzhou 310014, China.
authors.forename: Qin-shu
authors.initials: QS
authors.lastname: Shao
authors.forename: Xue-rong
authors.initials: XR
authors.lastname: Chen
authors.forename: Shou-chun
authors.initials: SC
authors.lastname: Zou
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002299:Cardia; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*