Aluminum inclusion macrophagic myofasciitis: a recently identified condition.
The authors conclude that the persistence of aluminum hydroxide at the site of intramuscular injection is a novel finding which has an exact significance that remains to be established fully. It seems mandatory to evaluate possible long-term adverse effects induced by this compound, because this issue has not been addressed (in the past, aluminum hydroxide was believed to be cleared quickly from the body). If safety concerns about the long-term effects of aluminum hydroxide are confirmed, novel and alternative vaccine adjuvants to rescue vaccine-based strategies should be proposed to ensure the enormous benefit for public health that these vaccines provide worldwide.
Gherardi
Romain K
RK
Muscle and Nerve Group, Henri Mondor University Hospital, Créteil, France. lauret@univ-paris12.fr
Authier
François-Jérôme
FJ
D000328:Adult; D000368:Aged; D000536:Aluminum Hydroxide / Q000009:adverse effects* / Q000276:immunology; D015673:Fatigue Syndrome, Chronic / Q000139:chemically induced / Q000276:immunology*; D005260:Female; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D018979:Myositis, Inclusion Body / Q000139:chemically induced / Q000276:immunology* / Q000503:physiopathology; D010592:Pharmaceutic Aids / Q000009:adverse effects*; D014612:Vaccines / Q000009:adverse effects*
D010592:Pharmaceutic Aids; D014612:Vaccines; D000536:Aluminum Hydroxide