Remarkable effect of a silicon group on the stereoselectivity of radical 5-exo-trig cyclizations.
[reaction: see text] Sulfonyl radical mediated 5-exo-trig cyclization of chiral 3-silylhepta-1,6-dienes has been shown to provide cyclopentanes having up to four stereogenic centers with an unexpectedly high level of stereocontrol.
James
Philippe
P
Université Bordeaux-I, Laboratoire de Chimie Organique et Organométallique, 351, Cours de la Libération, 33405 Talence Cedex, France.
Landais
Yannick
Y