title: Clinicopathologic study of hepatic Penicillium marneffei in Northern Thailand.
abstract: BACKGROUND
  Penicillium marneffei, an opportunistic fungus, is endemic in Southeast Asia, especially in human immunodeficiency virus-infected individuals living in northern Thailand.
  
  
  OBJECTIVE
  We present the results of a clinicopathologic study of hepatic penicilliosis among human immunodeficiency virus/acquired immunodeficiency syndrome patients.
  
  
  METHODS
  A search of liver biopsies in one institution from 1998 to 1999 identified 30 cases of penicilliosis.
  
  
  RESULTS
  Histologically, hepatic lesions could be classified into 1 of 3 patterns: diffuse, granulomatous, and mixed. The diffuse pattern showed a diffuse infiltration of foamy macrophages that contained numerous P marneffei. The granulomatous pattern showed a formation of multiple granulomata with various degrees of inflammatory cell infiltration. The mixed pattern showed features intermediate between the diffuse and granulomatous patterns. Liver function tests of the 3 pathologic pattern groups were evaluated, but there were no statistically significant differences in aspartate aminotransferase, alanine aminotransferase, or alkaline phosphatase levels among the various histologic groups.
  
  
  CONCLUSIONS
  To our knowledge, this is the largest series to date that documents the liver pathology that results from this pathogen. We hypothesize that the histologic patterns seen on biopsy reflect the level of the host's immunity. Hence, in addition to a diagnosis of penicilliosis, a liver biopsy may also provide an assessment of the host's immune status, whereas liver function tests do not.
authors.affiliation: Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. ayousukh@mail.med.cmu.ac.th
authors.forename: Amnat
authors.initials: A
authors.lastname: Yousukh
authors.forename: Prapan
authors.initials: P
authors.lastname: Jutavijittum
authors.forename: Pises
authors.initials: P
authors.lastname: Pisetpongsa
authors.forename: Taned
authors.initials: T
authors.lastname: Chitapanarux
authors.forename: Satawat
authors.initials: S
authors.lastname: Thongsawat
authors.forename: Masachika
authors.initials: M
authors.lastname: Senba
authors.forename: Kan
authors.initials: K
authors.lastname: Toriyama
mesh_terms: D001706:Biopsy; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008099:Liver / Q000382:microbiology / Q000473:pathology* / Q000503:physiopathology; D008107:Liver Diseases / Q000150:complications / Q000382:microbiology / Q000473:pathology*; D009181:Mycoses / Q000382:microbiology / Q000473:pathology*; D010407:Penicillium / Q000302:isolation & purification; D013785:Thailand