title: [Hypotensive cardio-circulatory failure and metabolic acidosis after suicidal intoxication with trimipramine and quetiapine. Case report and background].
abstract: The case of a 44-year-old female patient is reported, who ingested trimipramine and quetiapine in a suicide attempt. Initially sinus tachycardia and hypotension were seen, which resulted in a hypotensive cardio-circulatory failure despite fluid therapy and administration of catecholamines. Because of the life-threatening situation and the fact that the ingestion was 2 h prior to admission, a rapid transport to the next hospital was preferred to treatment with active charcoal. Intoxication with tricyclic antidepressants are very common in Europe and have a mortality of up to 15% in severe cases. The specific therapy consists of airway management, hemodynamic stabilization and primary elimination of the poison. Secondary detoxication is less important. The administration of the antidote physostigmine is controversial but carbo medicinalis should be given orally or via a gastric tube.
authors.affiliation: Karlsruhe, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Gabel
authors.forename: J
authors.initials: J
authors.lastname: Hinkelbein
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000506:poisoning*; D000931:Antidotes / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000506:poisoning*; D002606:Charcoal / Q000627:therapeutic use; D003987:Dibenzothiazepines / Q000506:poisoning*; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006333:Heart Failure / Q000139:chemically induced* / Q000503:physiopathology; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000503:physiopathology; D000069348:Quetiapine Fumarate; D012769:Shock / Q000139:chemically induced* / Q000503:physiopathology; D013406:Suicide, Attempted; D014299:Trimipramine / Q000506:poisoning*
chemical_list: D000928:Antidepressive Agents; D000931:Antidotes; D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D002606:Charcoal; D000069348:Quetiapine Fumarate; D014299:Trimipramine