title: Effect of caffeine administered intravenously on intracoronary-administered adenosine-induced coronary hemodynamics in patients with coronary artery disease.
abstract: It is believed that caffeine attenuates the coronary hyperemic response to adenosine by blocking the A2a receptors. We studied the effect of caffeine on adenosine-induced myocardial hyperemia measured by fractional flow reserve after intracoronary adenosine administration. Fractional flow reserve was not affected by intravenous caffeine infusion at a dose that was comparable to oral consumption.
authors.affiliation: Division of Cardiovascular Disease, Birmingham's Veterans Affair Medical Center, and Department of Medicine, University of Alabama at Birmingham, 35233, USA. raqel@cardio.dom.uab.edu
authors.forename: Raed A
authors.initials: RA
authors.lastname: Aqel
authors.forename: Gilbert J
authors.initials: GJ
authors.lastname: Zoghbi
authors.forename: James R
authors.initials: JR
authors.lastname: Trimm
authors.forename: Shawn A
authors.initials: SA
authors.lastname: Baldwin
authors.forename: Ami E
authors.initials: AE
authors.lastname: Iskandrian
mesh_terms: D000241:Adenosine / Q000008:administration & dosage*; D058917:Adenosine A2 Receptor Antagonists; D000328:Adult; D002110:Caffeine / Q000008:administration & dosage*; D003324:Coronary Artery Disease / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology*; D007262:Infusions, Intravenous; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D058917:Adenosine A2 Receptor Antagonists; D014665:Vasodilator Agents; D002110:Caffeine; D000241:Adenosine