title: Rewiring the transcriptional regulatory circuits of cells.
abstract: The molecular mechanisms that regulate gene expression can evolve either by changing the cis-acting DNA elements in promoters, or by replacing the trans-acting regulatory proteins. New data from yeast species show that both processes can happen.
authors.affiliation: Department of Genetics, Smurfit Institute, University of Dublin, Trinity College, Dublin 2, Ireland.
authors.forename: Devin R
authors.initials: DR
authors.lastname: Scannell
authors.forename: Ken
authors.initials: K
authors.lastname: Wolfe
mesh_terms: D002176:Candida albicans / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D020218:Response Elements; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D014157:Transcription Factors