Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas.
Cyclo-oxygenase (COX)-2 is induced in various types of cancer tissues. Here, we demonstrate stromal expression of both COX-2 and microsomal prostaglandin E(2) synthase (mPGES)-1 in gastrointestinal hamartomas developed in Lkb1(+/-), Smad4(+/-) and Cdx2(+/-)mice. These results suggest that PGE(2) produced by COX-2 and mPGES-1 plays an important role in hamartoma development regardless of the mutated genes causing hamartomas.
Takeda
H
H
Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
Miyoshi
H
H
Tamai
Y
Y
Oshima
M
M
Taketo
M M
MM
D055372:AMP-Activated Protein Kinases; D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D000071616:CDX2 Transcription Factor; D002352:Carrier Proteins; D051546:Cyclooxygenase 2; D004268:DNA-Binding Proteins / Q000235:genetics; D016147:Genes, Tumor Suppressor; D006222:Hamartoma / Q000235:genetics* / Q000473:pathology / Q000662:veterinary; D018398:Homeodomain Proteins / Q000235:genetics; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins; D019746:Intramolecular Oxidoreductases / Q000096:biosynthesis* / Q000235:genetics; D007527:Isoenzymes / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D010544:Peroxidases / Q000096:biosynthesis; D000071876:Prostaglandin-E Synthases; D011451:Prostaglandin-Endoperoxide Synthases / Q000096:biosynthesis* / Q000235:genetics; D017346:Protein Serine-Threonine Kinases; D015398:Signal Transduction; D051901:Smad4 Protein; D013272:Stomach Diseases / Q000235:genetics* / Q000473:pathology / Q000662:veterinary; D015534:Trans-Activators / Q000235:genetics; D016212:Transforming Growth Factor beta
D048868:Adaptor Proteins, Signal Transducing; D000071616:CDX2 Transcription Factor; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D047908:Intracellular Signaling Peptides and Proteins; D007527:Isoenzymes; D051901:Smad4 Protein; C490810:Smad4 protein, mouse; C491655:Stk11ip protein, mouse; D015534:Trans-Activators; D016212:Transforming Growth Factor beta; D010544:Peroxidases; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D017346:Protein Serine-Threonine Kinases; C491654:Stk11 protein, mouse; D055372:AMP-Activated Protein Kinases; D019746:Intramolecular Oxidoreductases; D000071876:Prostaglandin-E Synthases; C000605865:Ptges protein, mouse