title: The effect of dwell time on dialysate cancer antigen 125 appearance rates in patients on continuous ambulatory peritoneal dialysis.
abstract: The dialysate concentration of cancer antigen 125 (CA125) can be considered a reflection of mesothelial cell mass or turnover in stable continuous ambulatory peritoneal dialysis (CAPD) patients. The effect of dwell times exceeding 4 hours on CA125 appearance rate (CA125AR) is not known. Therefore, our objective in the present study was to analyze the effect of dwell time on CA125AR in stable CAPD patients. In 43 stable CAPD patients, we analyzed standard peritoneal permeability analyses (SPAs) performed with a 3.86% glucose dialysate, and night-dwell effluents from the night dwell prior to the SPA. Dialysate CA125 concentration was measured by radioimmunoassay (RIA II: Fujirebio Diagnostics, Malvern, PA, U.S.A.). Night-dwell CA125 correlated with the duration of the dwell (r = 0.32, p = 0.04) and with the CA125 concentration in the 4-hour dwell (r = 0.83, p < 0.001). The mean CA125AR in the SPA effluent was 97.8 +/- 46.3 U/min; in the overnight effluent, it was 108.8 +/- 73.7 U/min (nonsignificant). A good correlation was present between the CA125AR in the 4-hour dwells and in the overnight dwells (r = 0.82, p < 0.001). We conclude that using night dwells to regularly assess dialysate CA125--for instance, at every out-patient visit--is possible in CAPD patients, provided that appearance rate is calculated.
authors.affiliation: Division of Nephrology, Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
authors.forename: Sema
authors.initials: S
authors.lastname: Akman
authors.forename: Roos
authors.initials: R
authors.lastname: van Westrhenen
authors.forename: Dirk R
authors.initials: DR
authors.lastname: De Waart
authors.forename: Johan K
authors.initials: JK
authors.lastname: Hiralall
authors.forename: Machteld M
authors.initials: MM
authors.lastname: Zweers
authors.forename: Raymond T
authors.initials: RT
authors.lastname: Krediet
mesh_terms: D000328:Adult; D000368:Aged; D018394:CA-125 Antigen / Q000032:analysis*; D015314:Dialysis Solutions / Q000737:chemistry*; D006801:Humans; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D013997:Time Factors
chemical_list: D018394:CA-125 Antigen; D015314:Dialysis Solutions