Leptin-based immune intervention: current status and future directions.
Current understanding of the role of leptin has expanded from its narrow association with obesity to a variety of effects on different biological processes including immune function. More specifically, leptin links nutritional status and energy balance to regulation of pro-inflammatory T-helper 1 immune responses. This has prompted several studies of targeted intervention with leptin antagonists in rodents to suppress onset and/or progression of chronic inflammation and autoimmunity. This review presents current preclinical evidence and potential applications for leptin-based immune approaches aimed at improving therapy for chronic and autoimmune conditions.
La Cava
Antonio
A
Department of Medicine, University of California Los Angeles, 1000 Veteran Avenue 32-59, Los Angeles, CA 90095-1670, USA. alacava@mednet.ucla.edu
Matarese
Giuseppe
G
Ebling
Fanny M
FM
Hahn
Bevra H
BH
D000818:Animals; D001327:Autoimmune Diseases / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D020738:Leptin / Q000037:antagonists & inhibitors* / Q000097:blood / Q000276:immunology; D009752:Nutritional Status / Q000276:immunology; D011956:Receptors, Cell Surface / Q000037:antagonists & inhibitors / Q000276:immunology; D054411:Receptors, Leptin; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
C515448:LEPR protein, human; D020738:Leptin; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin