title: Markers of wound healing in vocal fold secretions from patients with laryngeal pathology.
abstract: This study seeks to determine the ability of enzyme-linked immunosorbent assays of vocal fold secretions to detect and describe the inflammatory response in the vocal folds. Vocal fold and palatal secretions were collected during operation from patients with a range of vocal fold disorders and from control patients. The secretions were subjected to assays for interleukin-1beta, prostaglandin E2, and transforming growth factor beta. The results indicate a differential expression of mediators associated with the wound healing cascade in the vocal folds. The prostaglandin E2 levels clearly differentiated vocal fold secretions associated with laryngeal disease versus control sites. Furthermore, the interleukin-1beta concentrations were significantly elevated in subjects with epithelial lesions of the vocal folds as opposed to lesions of the lamina propria. Although still in its infancy, such analysis may ultimately hold scientific and clinical utility in the study and management of patients with vocal fold disease.
authors.affiliation: Department of Otolaryngology and University of Pittsburgh Voice Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Ryan C
authors.initials: RC
authors.lastname: Branski
authors.forename: Clark A
authors.initials: CA
authors.lastname: Rosen
authors.forename: Katherine
authors.initials: K
authors.lastname: Verdolini
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Hebda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D015232:Dinoprostone / Q000032:analysis; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis*; D007375:Interleukin-1 / Q000032:analysis; D007818:Laryngeal Diseases / Q000601:surgery*; D008875:Middle Aged; D016212:Transforming Growth Factor beta / Q000032:analysis*; D014827:Vocal Cords / Q000378:metabolism* / Q000473:pathology; D014945:Wound Healing
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D007375:Interleukin-1; D016212:Transforming Growth Factor beta; D015232:Dinoprostone