Number of arginine-vasopressin neurons in the suprachiasmatic nuclei is not related to level or circadian characteristics of wheel-running activity in house mice.
House mouse lines bidirectionally selected for nest-building behavior show a correlation between number of AVP cells in the suprachiasmatic nuclei (SCN), the master circadian clock in mammals, and level of nest-building behavior as well as a correlation between wheel-running activity and SCN AVP content. Similar genetic correlations between wheel-running activity and nest-building behavior have been reported in house mouse lines selected for increased voluntary wheel-running behavior. These similarities in genetic correlation structure in independently selected mouse lines allowed us to test whether AVP in the SCN and wheel running activity are truly correlated traits under identical testing procedures. In the mouse lines selected for voluntary wheel-running, no difference was found between the lines selected for high levels of voluntary wheel-running and randomly-bred control lines in the number of AVP immunoreactive neurons in the SCN ( F1,6 = 0.09, NS; replicate line effect: F1,22 = 0.05, NS). This finding was confirmed at the level of individual variation, which revealed no relationship between number of AVP neurons in the SCN and total daily activity ( R = -0.086, NS, n = 24), or circadian organization (i.e., the chi-squared periodogram waveform amplitude; R = -0.071, NS). Therefore our data do not support the hypothesis that differences in activity level and the circadian expression of activity in young adult mice are related to differences in the number of AVP-immunoreactive cells in the SCN.
Hochstetler
Kelly J
KJ
Alaskan Basic Neuroscience Program, Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, Alaska.
Garland
Theodore
T
Swallow
John G
JG
Carter
Patrick A
PA
Bult-Ito
Abel
A
D000818:Animals; D001127:Arginine Vasopressin / Q000235:genetics*; D002452:Cell Count; D002940:Circadian Rhythm / Q000235:genetics*; D008297:Male; D051379:Mice; D009043:Motor Activity; D009425:Nesting Behavior; D009474:Neurons / Q000166:cytology; D012641:Selection, Genetic; D013045:Species Specificity; D013493:Suprachiasmatic Nucleus / Q000166:cytology*
D001127:Arginine Vasopressin