[Effect of electromagnetic pulse irradiation on mice reproduction].
OBJECTIVE
To evaluate the effect of electromagnetic pulse (EMP) irradiation on mice reproduction.


METHODS
Female/male Kunming mice, 6 - 8 weeks old, prior to mating, or female after pregnancy were treated with whole body irradiation by 6 x 10(4) V/m electromagnetic pulse (EMP) for five times. The pregnant mice were killed on the 18th days, and teratological markers were analysed.


RESULTS
EMP irradiation caused no significant changes in most of female organ weight and organ/body weight ratio. But it caused significant shortening in tail length of live foetus in the female mice before conception (prior to mating) or after pregnancy (P < 0.05), and obvious decrease in male offspring ratio (0.85 +/- 0.09 vs 1.09 +/- 0.17, P < 0.05). The male offspring ratio also significantly decreased (0.76 +/- 0.18 vs 1.09 +/- 0.17, P < 0.01) after male mice irradiated by EMP. The tail length of live foetus was shortened and male offspring sex ratio was increased after both male and female mice were irradiated by EMP. EMP irradiation also caused a significantly higher fetal death rate than normal control (P < 0.05). The embryo absorption rate was increased after irradiation except that was decreased in male mice.


CONCLUSIONS
EMP irradiation has effect on pregnancy and offspring development in both male and female mice before mating and in female mice after pregnancy.
Wang
Shui-ming
SM
Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China.
Wang
De-wen
DW
Peng
Rui-yun
RY
Chen
Hao-yu
HY
Gao
Ya-bing
YB
Cao
Xiao-zhe
XZ
Cui
Xue-mei
XM
Zhao
Mei-lan
ML
D000818:Animals; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D008297:Male; D051379:Mice; D011247:Pregnancy; D011827:Radiation; D012098:Reproduction / Q000528:radiation effects*