title: Pregnancy outcome of 30 fetuses with cystic hygroma diagnosed during the first 15 weeks of gestation.
abstract: The goal of the study was to assess the prognostic value of ultrasound finding of fetal cystic hygromas. Thirty cases of septated cystic hygromas were diagnosed at 10-15 weeks gestation by transabdominal ultrasound and followed through pregnancy. The rate of abnormal karyotype was found to be 61% and the global rate of unfavorable outcome, independently of karyotype result, as high as 96%. These data suggest that cautious genetic counselling should be offered when such cystic hygromas are noticed during the first 15 weeks of gestation, even with a normal karyotype.
authors.affiliation: Division of Medical Genetics, Geneva University Hospital, Switzerland.
authors.forename: A
authors.initials: A
authors.lastname: Paoloni-Giacobino
authors.forename: D
authors.initials: D
authors.lastname: Extermann
authors.forename: Ph
authors.initials: P
authors.lastname: Extermann
authors.forename: S Y
authors.initials: SY
authors.lastname: Dahoun
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations / Q000706:statistics & numerical data*; D000013:Congenital Abnormalities / Q000453:epidemiology*; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D007621:Karyotyping; D018191:Lymphangioma, Cystic / Q000000981:diagnostic imaging*; D011247:Pregnancy; D011256:Pregnancy Outcome; D013557:Switzerland / Q000453:epidemiology; D016216:Ultrasonography, Prenatal