title: Synthesis of condensed quinolines and quinazolines as DNA ligands.
abstract: Among new condensed quinolines and quinazolines the design of which were inspired by anti-cancer DNA-binding alkaloids such as camptothecin and batracyclin, DNA binding tests identify the 8-methoxy-7-piperazinylpropoxyindeno[1,2-b]quinolin-11-one tetracyclic system as a new motif for DNA recognition.
authors.affiliation: Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille 2, EA 2692, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille, France.
authors.forename: Natacha
authors.initials: N
authors.lastname: Malecki
authors.forename: Pascal
authors.initials: P
authors.lastname: Carato
authors.forename: Benoît
authors.initials: B
authors.lastname: Rigo
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Goossens
authors.forename: Raymond
authors.initials: R
authors.lastname: Houssin
authors.forename: Christian
authors.initials: C
authors.lastname: Bailly
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Hénichart
mesh_terms: D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D008024:Ligands; D015394:Molecular Structure; D009691:Nucleic Acid Denaturation; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D013050:Spectrometry, Fluorescence
chemical_list: D008024:Ligands; D011799:Quinazolines; D011804:Quinolines; D004247:DNA