title: [Origin and consequences of the hypodensity surrounding spontaneous intracerebral hemorrhage in the acute phase].
abstract: In the acute phase, spontaneous intracerebral hemorrhage is surrounded by hypodensity, the origin of which is controversial. Its clinical consequences are still under evaluation. Surrounding cerebral ischemia was suggested as its main etiology, but no experimental or clinical data currently supports this etiology. The hypodensity reflects the presence of cytotoxic and vasogenic edema secondary to prolonged contact between hemorrhage and adjacent brain tissue. This would mainly be due to local release of activated thrombin. However, other metabolites released from blood degradation products would also be involved. This edematous process is unique due to its early occurrence (as early as 2 hours), early maximum peak (24 hours), and regression over the next few days. In humans, no definitive proof exists that this edematous process of variable intensity is pathological. No specific treatment is currently available.
authors.affiliation: Clinique Universitaire de Neurochirurgie F, 33076 Bordeaux Cedex, France. jean-pierre.castel@chu-bordeaux.fr
authors.forename: J P
authors.initials: JP
authors.lastname: Castel
mesh_terms: D000208:Acute Disease; D000818:Animals; D001929:Brain Edema / Q000150:complications / Q000000981:diagnostic imaging; D002545:Brain Ischemia / Q000150:complications / Q000000981:diagnostic imaging; D002543:Cerebral Hemorrhage / Q000150:complications / Q000000981:diagnostic imaging*; D004195:Disease Models, Animal; D006801:Humans; D014057:Tomography, X-Ray Computed