Thyroid hormone, glucocorticoids, and prolactin at the nexus of physiology, reproduction, and toxicology.
A symposium at the 2003 Annual Meeting of the Society of Toxicology brought together an expert group of endocrinologists to review how non-reproductive hormones can affect the endocrine system. This publication captures the essence of those presentations. Paul Cooke and Denise Holsberger recapitulate the evidence of how thyroid hormones affect male and female reproduction, and reproductive development. Ray Witorsch summarizes the many effects of glucocorticoids on the reproductive system. Finally, Paul Sylvester reviews the mechanism of action of prolactin, and reminds us that this ancient hormone has many functions beyond lactation.
Cooke
Paul S
PS
Department of Veterinary Biosciences, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.
Holsberger
Denise R
DR
Witorsch
Raphael J
RJ
Sylvester
Paul W
PW
Meredith
John M
JM
Treinen
Kimberley A
KA
Chapin
Robert E
RE
D000818:Animals; D005260:Female; D005938:Glucocorticoids / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans; D007985:Leydig Cells / Q000378:metabolism / Q000502:physiology; D008297:Male; D010902:Pituitary Gland / Q000502:physiology; D011388:Prolactin / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D011981:Receptors, Prolactin / Q000378:metabolism; D012098:Reproduction / Q000502:physiology*; D013737:Testis / Q000502:physiology; D013963:Thyroid Hormones / Q000096:biosynthesis / Q000502:physiology*; D014116:Toxicology
D005938:Glucocorticoids; D011981:Receptors, Prolactin; D013963:Thyroid Hormones; D011388:Prolactin