5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors.
5(S)-Fluoro-N6-(iminoethyl)-l-lysine (14), an analogue of the potent, selective induced nitric oxide synthase (iNOS) inhibitor iminoethyl-l-lysine (1), was synthesized and found to be a selective iNOS inhibitor.
Hallinan
E Ann
EA
Pfizer, 4901 Searle Parkway, Skokie, Illinois 60077, USA. eahallinan@comcast.net
Hagen
Timothy J
TJ
Bergmanis
Arija
A
Moore
William M
WM
Jerome
Gina M
GM
Spangler
Dale P
DP
Stevens
Anna M
AM
Shieh
Huey S
HS
Manning
Pamela T
PT
Pitzele
Barnett S
BS
D018360:Crystallography, X-Ray; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000737:chemistry; D008239:Lysine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D052247:Nitric Oxide Synthase Type II
C483195:5-fluoro-N6-(iminoethyl)lysine; D007527:Isoenzymes; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D008239:Lysine