title: Serum insulin-like growth factor-I is positively associated with serum prostate-specific antigen in middle-aged men without evidence of prostate cancer.
abstract: We have examined the relationship between serum insulin-like growth factor-I (IGF-I) and prostate-specific antigen in 367 healthy men without evidence of prostate cancer and found a positive association (P = 0.05). In men without prostate cancer, serum prostate-specific antigen is closely related to prostate size, and our findings, therefore, suggest that IGF-I may induce prostatic epithelial proliferation. Higher circulating levels of IGF-I have been associated with increased risk of both prostate cancer and possibly benign prostatic hyperplasia. Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders.
authors.affiliation: Department of Health Sciences, University of York, and The Hull York Medical School, Heslington, York, UK.
authors.forename: Steven E
authors.initials: SE
authors.lastname: Oliver
authors.forename: Barney
authors.initials: B
authors.lastname: Barrass
authors.forename: David J
authors.initials: DJ
authors.lastname: Gunnell
authors.forename: Jenny L
authors.initials: JL
authors.lastname: Donovan
authors.forename: Tim J
authors.initials: TJ
authors.lastname: Peters
authors.forename: Raj A
authors.initials: RA
authors.lastname: Persad
authors.forename: David
authors.initials: D
authors.lastname: Gillatt
authors.forename: David E
authors.initials: DE
authors.lastname: Neal
authors.forename: Freddie C
authors.initials: FC
authors.lastname: Hamdy
authors.forename: Jeff M P
authors.initials: JM
authors.lastname: Holly
mesh_terms: D017677:Age Distribution; D000368:Aged; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000097:blood*
chemical_list: D007334:Insulin-Like Growth Factor I; D017430:Prostate-Specific Antigen