title: A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum.
abstract: A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.
authors.affiliation: Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Hebrew University of Jerusalem, Israel.
authors.forename: Avital
authors.initials: A
authors.lastname: Torres
authors.forename: Malka
authors.initials: M
authors.lastname: Hochberg
authors.forename: Inna
authors.initials: I
authors.lastname: Pergament
authors.forename: Reem
authors.initials: R
authors.lastname: Smoum
authors.forename: Valerie
authors.initials: V
authors.lastname: Niddam
authors.forename: Valery M
authors.initials: VM
authors.lastname: Dembitsky
authors.forename: Marina
authors.initials: M
authors.lastname: Temina
authors.forename: Inka
authors.initials: I
authors.lastname: Dor
authors.forename: Ovadia
authors.initials: O
authors.lastname: Lev
authors.forename: Morris
authors.initials: M
authors.lastname: Srebnik
authors.forename: Claes D
authors.initials: CD
authors.lastname: Enk
mesh_terms: D001203:Ascomycota / Q000737:chemistry* / Q000235:genetics; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004890:Erythema / Q000209:etiology / Q000517:prevention & control; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D008011:Lichens / Q000737:chemistry / Q000235:genetics; D011740:Pyrimidine Dimers / Q000737:chemistry / Q000528:radiation effects; D011759:Pyrrolidines / Q000737:chemistry* / Q000494:pharmacology; D011837:Radiation-Protective Agents / Q000737:chemistry* / Q000494:pharmacology*; D012867:Skin / Q000528:radiation effects; D013056:Spectrophotometry, Ultraviolet; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D005960:Glucosides; D011740:Pyrimidine Dimers; D011759:Pyrrolidines; D011837:Radiation-Protective Agents; C483008:collemin A