The effect of prenatal hypoxia and malnutrition on memory consolidation in the chick.
The contribution of hypoxia and malnutrition to cognitive impairments was investigated in chicks incubated in conditions of reduced gas exchange. Previous research has shown that reducing gas exchange during incubation by wrapping half the eggshell with an impermeable membrane results in impaired cognitive ability in young chicks. The results were interpreted within a three stage sequential model of memory using discriminated bead avoidance learning. Reducing gas exchange for 4 days from day 10 or 14, of the 21-day incubation, inhibits memory formation and consolidation into permanent storage. The nature of the cognitive deficit depended on the timing of the insult. Environmental hypoxia (14% oxygen), induced from days 10 to 14 and from days 14 to 18, replicated the memory deficits found previously when eggs were partially wrapped with a membrane. Oxygen is necessary to break down food and to provide energy to build tissue proteins, and therefore hypoxia (partial wrapping or environmental incubation) may indirectly cause malnutrition. Malnutrition, induced by removing 5%, 7.5% or 10% albumin from the egg prior to incubation, had no significant effect on memory consolidation. Raised corticosterone levels occurred in chicks malnourished by 5% and 7.5%, but brain sparing was only evident in chicks with 7.5% albumin removal. Hatch rates were very low in 10% malnourished chicks. Using the chick as a model of prenatal stress, we have been able to isolate the effects of hypoxia from contributing maternal factors.
Rodricks
Candice L
CL
Department of Physiology, Monash University, Melbourne, Victoria 3800, Australia. candice.rodricks@med.monash.edu.au
Rose
Ilona A
IA
Camm
Emily J
EJ
Jenkin
Graham
G
Miller
Suzanne L
SL
Gibbs
Marie E
ME
D000367:Age Factors; D000418:Albumins / Q000172:deficiency; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001522:Behavior, Animal; D001835:Body Weight; D002645:Chickens; D003345:Corticosterone / Q000097:blood; D004193:Discrimination Learning / Q000502:physiology; D004528:Egg Shell / Q000378:metabolism*; D006400:Hematocrit; D000860:Hypoxia / Q000503:physiopathology*; D044342:Malnutrition / Q000503:physiopathology*; D008568:Memory / Q000502:physiology*; D009929:Organ Size / Q000502:physiology; D010100:Oxygen / Q000378:metabolism*; D013045:Species Specificity
D000418:Albumins; D010100:Oxygen; D003345:Corticosterone