Biological evaluation of hydroxyapatite/poly-L-lactide (HAp/PLLA) composite biomaterials with poly-L-lactide of different molecular weights intraperitoneally implanted into mice.
Histopathologic analysis of the tissue with HAp/PLLA implants was made and the leukocyte formula and chemiluminescence response of peritoneal phagocytes 2, 7 and 12 weeks after intraperitoneal implantation studied. Implants were made of HAp/PLLA biocomposites with PLLA molecular weights of 50000 (HAp/PLLA(50)) and 430000 g/mol (HAp/PLLA(430)) and of crushed devitalized femur bone of a young Wistar rat. Leukocyte formula and chemiluminescence of peritoneal phagocytes showed no systemic inflammatory response. The studied implants caused locally weak inflammatory reaction. The resorption of implants ranges in intensity (polymer resorption, i.e. disappearance rate), from the highest with the bone implants, low with HAp/PLLA(50), to the lowest with the HAp/PLLA(430) implants. Good resorption of the biocomposites and its mutual ingrowth with connective tissue prove their good biocompatibility.
Najman
S
S
Faculty of Medicine, University of Nis, 18000 Nis, Yugoslavia.
Savic
V
V
Djordjevic
Lj
Lj
Ignjatovic
N
N
Uskokovic
D
D
D020341:Absorbable Implants / Q000009:adverse effects*; D000818:Animals; D018786:Bone Substitutes / Q000009:adverse effects* / Q000737:chemistry; D017886:Durapatite / Q000009:adverse effects* / Q000737:chemistry; D005549:Foreign-Body Reaction / Q000209:etiology* / Q000473:pathology*; D008297:Male; D008420:Manufactured Materials / Q000009:adverse effects; D008422:Materials Testing; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D010537:Peritoneum / Q000473:pathology / Q000601:surgery; D011091:Polyesters / Q000009:adverse effects* / Q000737:chemistry; D016459:Prosthesis-Related Infections / Q000209:etiology* / Q000473:pathology*
D018786:Bone Substitutes; D011091:Polyesters; C033616:poly(lactide); D017886:Durapatite