Necrolytic migratory erythema: case report and clinical review.
BACKGROUND
Necrolytic Migratory Erythema (NME) is a rarely encountered dermatologic condition. It is the characteristic feature of a paraneoplastic syndrome associated with neuroendocrine pancreatic tumors. A case of NME initially diagnosed and treated as psoriasis is reviewed. A review of the current literature regarding NME is also included.


OBJECTIVE
The purpose of this report is to familiarize dermatologists with a rare and potentially fatal disorder. Early recognition of NME can lead to possible cure, while delayed identification of the disease is associated with metastatic disease and a poor prognosis for the patient.


CONCLUSIONS
When evaluating the patient who presents with a dermatitis and weight loss, it is important to exercise great caution. The differential diagnosis should be re-evaluated in a disease that is not responsive to first-line therapy before further treatment is considered.
Adam
David N
DN
Department of Medicine, University of Toronto, Ontario, Canada. dnadam@interchange.ubc.ca
Cohen
Paul D
PD
Ghazarian
Danny
D
D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D004890:Erythema / Q000188:drug therapy* / Q000209:etiology; D005935:Glucagonoma / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D015282:Octreotide / Q000627:therapeutic use; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging; D010257:Paraneoplastic Syndromes / Q000188:drug therapy* / Q000209:etiology; D011859:Radiography; D016896:Treatment Outcome
D018931:Antineoplastic Agents, Hormonal; D015282:Octreotide