title: [Study on apoptosis of lung tissue cells in patients with severe brain injury complicated with aspiration-induced lung injury].
abstract: OBJECTIVE
  To investigate the role of apoptosis of pulmonary cells in aspiration induced lung injury in patients with severe brain injury with or without aspiration-induced lung injury.
  
  
  METHODS
  The Glasgow scale (GCS) of 11 dead patients with severe closed brain injury was 3-8. There 11 cases were divided into aspiration-induced lung injury (AILI) and non-aspiration-induced lung injury (NAILI) groups. The plasma levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-8 (IL-8) were measured, and the ratio of apoptosis in lung tissue cells was also determined.
  
  
  RESULTS
  The plasma levels of TNF-alpha and IL-8 in NAILI and AILI groups were (2.17+/-0.41)nug/L vs. (3.14+/-0.28)nug/L and (0.42+/-0.05)nug/L vs. (0.91+/-0.08) nug/L (P<0.05) respectively. Lung tissue cell apoptosis ratio was significantly higher in AILI group than NAILI group (P<0.01).
  
  
  CONCLUSIONS
  TNF-alpha and IL-8 may induce apoptosis in lung tissues through different signaling pathway. During the early phase of aspiration-induced lung injury complicating severe closed brain injury, apoptosis in cells of lung tissue may play a role in the pathogenes.
authors.affiliation: Department of Emergency, General Hospital of PLA, Beijing 100853, China.
authors.forename: Tan-Shi
authors.initials: TS
authors.lastname: Li
authors.forename: Di-Cheng
authors.initials: DC
authors.lastname: Yin
authors.forename: Xu-Hui
authors.initials: XH
authors.lastname: Wu
authors.forename: Yang-Li
authors.initials: YL
authors.lastname: Song
authors.forename: Ming
authors.initials: M
authors.lastname: Yin
authors.forename: Hong
authors.initials: H
authors.lastname: Shen
authors.forename: Quan-Ying
authors.initials: QY
authors.lastname: He
mesh_terms: D000328:Adult; D017209:Apoptosis; D001344:Autopsy; D001930:Brain Injuries / Q000097:blood / Q000150:complications*; D005260:Female; D006801:Humans; D020287:In Situ Nick-End Labeling; D016209:Interleukin-8 / Q000097:blood; D008168:Lung / Q000473:pathology*; D008297:Male; D011015:Pneumonia, Aspiration / Q000209:etiology; D012128:Respiratory Distress Syndrome / Q000097:blood* / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha