title: Should IACUCs review scientific merit of animal research projects?
abstract: Whether IACUCs should review animal research protocols for scientific merit is not addressed in the federal regulations, resulting in ongoing confusion on the subject. The authors examine this issue, discuss the pros and cons, suggest how IACUCs can go about reviewing protocols for scientific merit, and question what effect recent changes in regulations will have on this issue.
authors.affiliation: IACUC, Nebraska Medical Center, Omaha, 68198-7830, USA. mman@unmc.edu
authors.forename: Michael D
authors.initials: MD
authors.lastname: Mann
authors.forename: Ernest D
authors.initials: ED
authors.lastname: Prentice
mesh_terms: D035661:Animal Care Committees / Q000458:organization & administration*; D032761:Animal Experimentation / Q000941:ethics / Q000592:standards*; D000827:Animal Welfare / Q000941:ethics / Q000331:legislation & jurisprudence; D000818:Animals; D000830:Animals, Laboratory; D003362:Cost-Benefit Analysis; D010380:Peer Review; D012106:Research / Q000191:economics / Q000331:legislation & jurisprudence / Q000592:standards; D012107:Research Design / Q000331:legislation & jurisprudence / Q000592:standards*