title: Axillary granular parakeratosis.
abstract: BACKGROUND
  Granular parakeratosis is a hyperkeratotic eruption of unknown etiology that occurs in the axilla and other intertriginous areas. The histologic features are unique for the retention of keratohyalin granules in the stratum corneum.
  
  
  OBJECTIVE
  The aim of the article is to review the clinical manifestations and treatment of granular parakeratosis.
  
  
  METHODS
  A case report and literature review are presented.
  
  
  RESULTS
  Twenty-six cases of granular parakeratosis now have been reported and reviewed.
  
  
  CONCLUSIONS
  Granular parakeratosis occurs predominantly in middle age women and most frequently in the axilla. A number of treatments have been applied to the 26 cases reported to date, without consistent responses. No evidence-based therapy can be suggested at present.
authors.affiliation: Department of Dermatology and Pathology, University of Virginia Health System, Charlottesville 22908-0718, USA. jce2n@virginia.edu
authors.forename: Jospeh C
authors.initials: JC
authors.lastname: English
authors.forename: Amalie S
authors.initials: AS
authors.lastname: Derdeyn
authors.forename: Wendy M
authors.initials: WM
authors.lastname: Wilson
authors.forename: James W
authors.initials: JW
authors.lastname: Patterson
mesh_terms: D000068816:Adapalene; D000328:Adult; D001365:Axilla; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009281:Naphthalenes / Q000627:therapeutic use*; D010241:Parakeratosis / Q000188:drug therapy*
chemical_list: D003879:Dermatologic Agents; D009281:Naphthalenes; D000068816:Adapalene