Unraveling V(D)J recombination; insights into gene regulation.
V(D)J recombination assembles antigen receptor genes from component gene segments. We review findings that have shaped our current understanding of this remarkable mechanism, with a focus on two major reports--the first detailed comparison of germline and rearranged antigen receptor loci and the discovery of the recombination activating gene-1.
Jung
David
D
Howard Hughes Medical Institute, The Children's Hospital, The CBR Institute for Biomedical Research, Inc., Harvard Medical School, Boston, MA 02115, USA.
Alt
Frederick W
FW
D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology; D003001:Cloning, Molecular; D004249:DNA Damage; D005786:Gene Expression Regulation; D016654:Genes, RAG-1 / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D008957:Models, Genetic; D009369:Neoplasms / Q000235:genetics; D011946:Receptors, Antigen; D011995:Recombination, Genetic; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000502:physiology; D045567:VDJ Recombinases / Q000378:metabolism / Q000502:physiology*
D011946:Receptors, Antigen; D045567:VDJ Recombinases