Serum insulin-like growth factor-I is positively associated with serum prostate-specific antigen in middle-aged men without evidence of prostate cancer.
We have examined the relationship between serum insulin-like growth factor-I (IGF-I) and prostate-specific antigen in 367 healthy men without evidence of prostate cancer and found a positive association (P = 0.05). In men without prostate cancer, serum prostate-specific antigen is closely related to prostate size, and our findings, therefore, suggest that IGF-I may induce prostatic epithelial proliferation. Higher circulating levels of IGF-I have been associated with increased risk of both prostate cancer and possibly benign prostatic hyperplasia. Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders.
Oliver
Steven E
SE
Department of Health Sciences, University of York, and The Hull York Medical School, Heslington, York, UK.
Barrass
Barney
B
Gunnell
David J
DJ
Donovan
Jenny L
JL
Peters
Tim J
TJ
Persad
Raj A
RA
Gillatt
David
D
Neal
David E
DE
Hamdy
Freddie C
FC
Holly
Jeff M P
JM
D017677:Age Distribution; D000368:Aged; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000097:blood*
D007334:Insulin-Like Growth Factor I; D017430:Prostate-Specific Antigen