Establishing the synthetic origin of amphetamines by 2H NMR spectroscopy.
Nine samples of N-acetyl-3,4-methylenedioxyamphetamine (N-acetyl-MDA), prepared according to the most common synthetic procedures, are submitted to (2)H NMR spectroscopy. The relative deuterium content at the various sites of the molecule is shown to depend on its synthetic history. The technique provides a chemical fingerprint of N-acetyl-MDAs and it can be used to trace back the precursor materials and the synthetic pathways employed in the preparation of the samples.
Armellin
Silvia
S
Dipartimento di Chimica, Materiali, Ingegneria Chimica, Politecnico di Milano, ed Istituto CNR per la Chimica del Riconoscimento Molecolare, Via Mancinelli 7, I-20131 Milano, Italy.
Brenna
Elisabetta
E
Fronza
Giovanni
G
Fuganti
Claudio
C
Pinciroli
Matteo
M
Serra
Stefano
S
D003903:Deuterium / Q000032:analysis; D004335:Drug and Narcotic Control / Q000379:methods; D013287:Illicit Drugs / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000138:chemical synthesis / Q000737:chemistry*
D013287:Illicit Drugs; D003903:Deuterium; D018817:N-Methyl-3,4-methylenedioxyamphetamine