title: Synthesis and biological evaluation of novel coumarin derivatives with a 7-azomethine linkage.
abstract: The synthesis of several novel coumarin derivatives with a 7-azomethine linkage was carried out starting from 7-formyl-coumarin. The compounds were tested in vivo for their anti-inflammatory activity and in vitro for their antioxidant ability. Compounds 3a and 3e possess significant protection against carrageenin induced rat paw edema.
authors.affiliation: Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
authors.forename: Christos A
authors.initials: CA
authors.lastname: Kontogiorgis
authors.forename: Dimitra J
authors.initials: DJ
authors.lastname: Hadjipavlou-Litina
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001391:Azo Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D002351:Carrageenan / Q000633:toxicity; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D006614:Hindlimb / Q000187:drug effects / Q000378:metabolism; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D001391:Azo Compounds; D003374:Coumarins; D002351:Carrageenan