title: Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway.
authors.affiliation: Max-Planck-Institut für molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.
authors.forename: Herbert
authors.initials: H
authors.lastname: Waldmann
authors.forename: Ioanna-Maria
authors.initials: IM
authors.lastname: Karaguni
authors.forename: Mercedes
authors.initials: M
authors.lastname: Carpintero
authors.forename: Eleni
authors.initials: E
authors.lastname: Gourzoulidou
authors.forename: Christian
authors.initials: C
authors.lastname: Herrmann
authors.forename: Christoph
authors.initials: C
authors.lastname: Brockmann
authors.forename: Hartmut
authors.initials: H
authors.lastname: Oschkinat
authors.forename: Oliver
authors.initials: O
authors.lastname: Müller
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism / Q000494:pharmacology; D015153:Blotting, Western; D002461:Cell Line, Transformed / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D011905:Genes, ras / Q000235:genetics; D006160:Guanosine Triphosphate / Q000378:metabolism; D020128:Inhibitory Concentration 50; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D008958:Models, Molecular; D010766:Phosphorylation / Q000187:drug effects; D011485:Protein Binding / Q000187:drug effects; D019908:Proto-Oncogene Proteins c-raf / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology; D013050:Spectrometry, Fluorescence; D013467:Sulindac / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013467:Sulindac; D006160:Guanosine Triphosphate; D019908:Proto-Oncogene Proteins c-raf; D020928:Mitogen-Activated Protein Kinases; D018631:ras Proteins