title: Use of IQ-adjusted norms to predict progressive cognitive decline in highly intelligent older individuals.
abstract: Identifying high-functioning older individuals in preclinical phases of Alzheimer's disease (AD) may require more sensitive methods than the standard approach. The authors explored the utility of adjusting for premorbid intelligence to predict progressive cognitive decline or Mild Cognitive Impairment (MCI) in 42 highly intelligent older individuals. When scores were adjusted for baseline IQ, 9 participants had executive impairments, 11 had memory impairments, and 22 scored in the normal range. None were impaired according to standard age norms. Three and a half years later, 9 participants with IQ-adjusted memory impairment declined in naming, visuospatial functioning, and memory; 6 convened to MCI. Three participants with normal memory declined. Implications for using IQ-adjusted norms to predict preclinical AD are discussed.
authors.affiliation: Division of Cognitive and Behavioral Neurology, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. drentz@partners.org
authors.forename: Dorene M
authors.initials: DM
authors.lastname: Rentz
authors.forename: Terri J
authors.initials: TJ
authors.lastname: Huh
authors.forename: Robert R
authors.initials: RR
authors.lastname: Faust
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Budson
authors.forename: Leonard F M
authors.initials: LF
authors.lastname: Scinto
authors.forename: Reisa A
authors.initials: RA
authors.lastname: Sperling
authors.forename: Kirk R
authors.initials: KR
authors.lastname: Daffner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000503:physiopathology; D015331:Cohort Studies; D004522:Educational Status; D005260:Female; D005500:Follow-Up Studies; D015577:Geriatric Assessment; D006801:Humans; D007360:Intelligence / Q000145:classification / Q000502:physiology*; D007361:Intelligence Tests / Q000592:standards / Q000706:statistics & numerical data; D016014:Linear Models; D008297:Male; D008568:Memory; D008569:Memory Disorders / Q000503:physiopathology; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011237:Predictive Value of Tests; D011340:Problem Solving / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics