title: First functionalized MRI contrast agent recognizing vascular lesions.
abstract: A new MRI-contrast agent, EB-DTPA-Gd, that has an Evans Blue analogue as a sensing unit for endothelium lesions, was designed and synthesized. The agent also has diethylenetriamine-N,N,N',N",N"-pentaacetic acid-Gd complex (Gadolinium-DTPA) units, which have been used as detection units for T1-weighted MRI. The EB-DTPA-Gd was able to recognize and adsorb to the vascular endothelium-denuded region of porcine aorta, and to decrease the relaxation time of circumferential water's protons, making possible MR imaging of the endothelium-denuded region. The compound can be employed as a contrast agent for the imaging of vascular lesions using MRI.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: Tatsuhiro
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Ikuta
authors.forename: Keiji
authors.initials: K
authors.lastname: Oi
authors.forename: Kohtaro
authors.initials: K
authors.lastname: Abe
authors.forename: Toyokazu
authors.initials: T
authors.lastname: Uwatoku
authors.forename: Masaharu
authors.initials: M
authors.lastname: Murata
authors.forename: Noboru
authors.initials: N
authors.lastname: Shigetani
authors.forename: Kengo
authors.initials: K
authors.lastname: Yoshimitsu
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shimokawa
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Katayama
mesh_terms: D003287:Contrast Media; D019786:Gadolinium DTPA / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D014652:Vascular Diseases / Q000175:diagnosis*
chemical_list: D003287:Contrast Media; C483332:EB-DTPA-Gd; D019786:Gadolinium DTPA