title: Consensus design of repeat proteins.
abstract: Consensus design is a valuable protein-engineering method that is based on statistical information derived from sequence alignments of homologous proteins. Recently, consensus design was adapted to repeat proteins. We discuss the potential of this novel repeat-based approach for the design of consensus repeat proteins and repeat protein libraries and summarize recent results from such experiments.
authors.affiliation: Biochemisches Institut, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
authors.forename: Patrik
authors.initials: P
authors.lastname: Forrer
authors.forename: H Kaspar
authors.initials: HK
authors.lastname: Binz
authors.forename: Michael T
authors.initials: MT
authors.lastname: Stumpp
authors.forename: Andreas
authors.initials: A
authors.lastname: Plückthun
mesh_terms: D016384:Consensus Sequence; D019151:Peptide Library; D011487:Protein Conformation; D015202:Protein Engineering / Q000379:methods*; D011506:Proteins / Q000737:chemistry*
chemical_list: D019151:Peptide Library; D011506:Proteins