title: [Detection of hepatitis E virus on a blood donor and its infectivity to rhesus monkey].
abstract: OBJECTIVE
  To understand the infectivity and pathogenicity of the plasma of hepatitis E virus (HEV) viremia to primate animals.
  
  
  METHODS
  RNA fragment of HEV genotype IV was detected on one healthy donor who was positive for anti-HEV IgM and negative for anti-HEV IgG. Then 10 ml plasma from above donor was transfused to rhesus monkey to observe its infectivity and pathogenicity.
  
  
  RESULTS
  Acute hepatitis E was developed in rhesus monkey who accept HEV RNA positive plasma. It was confirmed by virological, immunological, biochemical and histopathological data.
  
  
  CONCLUSIONS
  Acute hepatitis E can be induced by plasma transfusion of HEV viremia, which indicate the possibility of transfusion transmitted hepatitis E
authors.affiliation: The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen University, Xiamen 361005, China.
authors.forename: Ning-shao
authors.initials: NS
authors.lastname: Xia
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Ying-jie
authors.initials: YJ
authors.lastname: Zheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Qiu
authors.forename: Sheng-xiang
authors.initials: SX
authors.lastname: Ge
authors.forename: Xiang-zhong
authors.initials: XZ
authors.lastname: Ye
authors.forename: Shan-hai
authors.initials: SH
authors.lastname: Ou
mesh_terms: D000208:Acute Disease; D000818:Animals; D001782:Blood Donors; D016751:Hepatitis E / Q000635:transmission*; D016752:Hepatitis E virus / Q000302:isolation & purification*; D006801:Humans; D008253:Macaca mulatta; D012367:RNA, Viral / Q000097:blood; D065227:Transfusion Reaction
chemical_list: D012367:RNA, Viral