Protein degradation: CUL-3 and BTB--partners in proteolysis.
In early C. elegans embryos, the transition from meiosis to mitosis requires degradation of the MEI-1 protein. A novel class of SCF-like ubiquitin ligases has been identified that mediates this process. These ligases contain the CUL-3 scaffold at their core and use a BTB-domain protein in substrate recognition.
van den Heuvel
Sander
S
Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149, 13th St., Charlestown, Massachusetts 02129, USA. heuvel@helix.mgh.harvard.edu
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D004625:Embryo, Nonmammalian; D008540:Meiosis / Q000502:physiology; D008938:Mitosis / Q000502:physiology; D008958:Models, Molecular; D010447:Peptide Hydrolases / Q000378:metabolism* / Q000502:physiology; D044843:SKP Cullin F-Box Protein Ligases / Q000378:metabolism*
D029742:Caenorhabditis elegans Proteins; D044843:SKP Cullin F-Box Protein Ligases; D010447:Peptide Hydrolases; D000251:Adenosine Triphosphatases; C086678:MEI-1 protein, C elegans