Acute renal failure on immune reconstitution in an HIV-positive patient with miliary tuberculosis.
Immune reconstitution syndrome following HAART in human immunodeficiency virus (HIV)-infected patients is characterized by inflammatory worsening of organ functions despite improvement in HIV surrogate markers of HIV infection. We describe a patient with miliary tuberculosis and urinary shedding of acid fast bacilli who developed acute renal failure 8 weeks after initiation of antituberculosis therapy and 6 weeks after initiation of HAART. The diagnostic workup and further course of disease implicated immune reconstitution syndrome as the cause of acute renal failure.
Jehle
Andreas W
AW
Division of Transplantation Immunology and Nephrology, University Hospitals Basel, Basel, Switzerland.
Khanna
Nina
N
Sigle
Jörg-Peter
JP
Glatz-Krieger
Katharina
K
Battegay
Manuel
M
Steiger
Jürg
J
Dickenmann
Michael
M
Hirsch
Hans H
HH
D058186:Acute Kidney Injury / Q000209:etiology / Q000276:immunology*; D023241:Antiretroviral Therapy, Highly Active; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014391:Tuberculosis, Miliary / Q000276:immunology*