Evidence for the presence of the Kennedy and Bremer- Greenberg pathways in Caenorhabditis elegans.
Nematodes were found to synthesize phosphorylcholine-containing molecules not present in higher organisms, i.e. phosphorylcholine-substituted glycosphingolipids and (glyco)proteins. Investigations on the biosynthesis of these structures provided first biochemical evidence for the presence of the Kennedy and Bremer-Greenberg pathways in the model organism Caenorhabditis elegans.
Lochnit
Günter
G
Institute of Biochemistry, Faculty of Medicine, University of Giessen, D-35392 Giessen, Germany.
Geyer
Rudolf
R
D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism*; D002250:Carbon Radioisotopes; D002798:Diacylglycerol Cholinephosphotransferase / Q000037:antagonists & inhibitors; D004591:Electrophoresis, Polyacrylamide Gel; D005204:Farnesol / Q000494:pharmacology; D006023:Glycoproteins / Q000096:biosynthesis*; D006028:Glycosphingolipids / Q000096:biosynthesis*; D010767:Phosphorylcholine / Q000378:metabolism*
D002250:Carbon Radioisotopes; D006023:Glycoproteins; D006028:Glycosphingolipids; D010767:Phosphorylcholine; D005204:Farnesol; D002798:Diacylglycerol Cholinephosphotransferase