title: Selectins facilitate carcinoma metastasis and heparin can prevent them.
abstract: Selectins are cell adhesion molecules mediating attachment of leukocytes to activated endothelium as well as the adhesion reaction of tumors during malignancy. Heparin, which is known to attenuate metastasis, is a potent blocker of selectins. Here, the role of selectins in metastasis and the potential of heparin to modulate malignancy are discussed.
authors.affiliation: Institute of Physiology, University of Zürich, CH-8057 Zürich, Switzerland.
authors.forename: Lubor
authors.initials: L
authors.lastname: Borsig
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D009362:Neoplasm Metastasis / Q000503:physiopathology* / Q000517:prevention & control*; D019087:Selectins / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D019087:Selectins; D006493:Heparin