Hypolipidemic effect of a prodrug containing nicotinic acid in rats. Correlation with plasmatic levels.
We have studied a macromolecular prodrug that contains nicotinic acid bound on a polymeric support of dextran. We have determined plasmatic levels of nicotinic acid, by a HPLC method, after macromolecular conjugate administration for a 24 hours period. In order to study the hypolipidemic effect, triglyceride levels were determined and correlated with plasmatic levels of nicotinic acid. The obtained data show that, starting from 6 hours after polymeric conjugate administration, plasmatic levels of nicotinic acid are high enough to determine a significantly decrease in triglycerides level. As a conclusion we assume that the active substance was gradually released from the polymeric support leading to a prolonged presence of the active substance in the body, which caused a lowered triglycerides level.
Filip
Cristiana
C
Department of Biochemistry, School of Medicine, University of Medicine and Pharmacy, Gr.T. Popa, Iaşi.
Ungureanu
Didona
D
Gheorghiţă
Nastasia
N
Ghitler
N
N
Mocanu
G
G
Nechifor
M
M
D000704:Analysis of Variance; D000818:Animals; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D023421:Models, Animal; D009525:Niacin / Q000494:pharmacology*; D011355:Prodrugs / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood*
D000960:Hypolipidemic Agents; D011355:Prodrugs; D014280:Triglycerides; D009525:Niacin