title: Relationship between chronic tension-type headache, cranial hemodynamics, and cerebrospinal pressure: study involving provocation with sumatriptan.
abstract: OBJECTIVE
  To study the relationship between chronic tension-type headache, cranial hemodynamics, and cerebrospinal pressure.
  
  
  BACKGROUND
  Cerebrospinal pressure has been found to be above 200 mm in about 50% of patients with chronic tension-type headache.
  
  
  METHODS
  Heart rate, blood pressure, common carotid artery diameter and blood flow, and craniovascular resistance and pain at regular intervals before, during, and after head-down tilt-a procedure which increases cerebrospinal pressure, were recorded. After head-down tilt, subcutaneous injections of either placebo or 6 mg of sumatriptan were administered. Chronic tension-type headache intensity before and after withdrawal of 20 mL of cerebrospinal fluid was documented. Cerebrospinal pressure and chronic tension-type headache intensity were measured after subcutaneous injection of 6 mg of sumatriptan.
  
  
  RESULTS
  Head-down tilt provoked an increase of headache compared with baseline. Common carotid artery blood flow decreased and craniovascular resistance increased after sumatriptan injection, but not after placebo injection. The pain decreased after head-down tilt and placebo injection, but not after sumatriptan injection. Chronic tension-type headache intensity decreased in all 4 patients studied after withdrawal of 20 mL of cerebrospinal fluid. Cerebrospinal pressure increased in 5 patients with chronic tension-type headache after subcutaneous injection of 6 mg of sumatriptan with slight or no increase of pain.
  
  
  CONCLUSIONS
  The results indicated that cerebrospinal pressure or intracranial venous pressure (or both) are related to chronic tension-type headache.
authors.affiliation: Department of Neurology, Karolinska Hospital, Huddinge University Hospital, Stockholm, Sweden.
authors.forename: Jan
authors.initials: J
authors.lastname: Hannerz
authors.forename: Tomas
authors.initials: T
authors.lastname: Jogestrand
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017536:Carotid Artery, Common / Q000187:drug effects / Q000503:physiopathology*; D002908:Chronic Disease; D005260:Female; D018475:Head-Down Tilt; D006801:Humans; D007427:Intracranial Pressure; D008297:Male; D008875:Middle Aged; D011312:Pressure; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D012886:Skull / Q000098:blood supply*; D018170:Sumatriptan / Q000494:pharmacology*; D018781:Tension-Type Headache / Q000134:cerebrospinal fluid / Q000503:physiopathology*
chemical_list: D017366:Serotonin Receptor Agonists; D018170:Sumatriptan