3-(2-pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives as high affinity human 5-HT(1B/1D) ligands.
A series of 3-(2-pyrrolidin-1-ylethyl)-5-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives (2) has been prepared using parallel synthesis techniques, and their structure-activity relationships studied. High affinity human 5-HT(1B/1D) (h5-HT(1B/1D)) ligands have been identified.
Egle
Ian
I
NPS Pharmaceuticals Inc, 6850 Goreway Dr, Mississauga, Ontario, Canada L4V 1V7. iegle@npsp.com
MacLean
Neil
N
Demchyshyn
Lidia
L
Edwards
Louise
L
Slassi
Abdelmalik
A
Tehim
Ashok
A
D006801:Humans; D007211:Indoles / Q000737:chemistry* / Q000378:metabolism*; D008024:Ligands; D011725:Pyridines / Q000737:chemistry* / Q000378:metabolism*; D044302:Receptor, Serotonin, 5-HT1B / Q000378:metabolism*; D013329:Structure-Activity Relationship
D007211:Indoles; D008024:Ligands; D011725:Pyridines; D044302:Receptor, Serotonin, 5-HT1B