title: Screening of Brazilian basidiomycetes for antimicrobial activity.
abstract: A total of 103 isolates of basidiomycetes, representing 84 species from different Brazilian ecosystems, were evaluated for their antifungal and antibacterial activity in a panel of pathogenic and non-pathogenic microorganisms. Tissue plugs of the fruiting bodies were cultivated in liquid media and the whole culture extracted with ethyl acetate. Crude extracts from Agaricus cf. nigrecentulus, Agrocybe perfecta, Climacodon pulcherrimus, Gloeoporus thelephoroides, Hexagonia hydnoides, Irpex lacteus, Leucoagaricus cf. cinereus, Marasmius cf. bellus, Marasmius sp., Nothopanus hygrophanus, Oudemansiella canarii, Pycnoporus sanguineus, Phellinus sp., and Tyromyces duracinus presented significant activity against one or more of the target microorganisms. Eight isolates were active only against bacteria while three inhibited exclusively the growth of fungi. Two extracts presented wide antimicrobial spectrum and were active against both fungi and bacteria. Differences in the bioactivity of extracts obtained from isolates from the same species were observed.
authors.affiliation: Departamento de Microbiologia, Instituto de Ci ncias Biol gicas, Universidade Federal de Minas Gerais Rachou-Fiocruz, Belo Horizonte, MG, Brasil.
authors.forename: Luiz Henrique
authors.initials: LH
authors.lastname: Rosa
authors.forename: Kátia M Gomes
authors.initials: KM
authors.lastname: Machado
authors.forename: Camila Cristina
authors.initials: CC
authors.lastname: Jacob
authors.forename: Marina
authors.initials: M
authors.lastname: Capelari
authors.forename: Carlos Augusto
authors.initials: CA
authors.lastname: Rosa
authors.forename: Carlos Leomar
authors.initials: CL
authors.lastname: Zani
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D002175:Candida / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010936:Plant Extracts