Synthesis and biological results of the technetium-99m-labeled 4-nitroimidazole for imaging tumor hypoxia.
1-(4-Nitroimidazole-1-yl)-propanhydroxyiminoamide (N4IPA) was synthesized. The biodistribution of 99mTc-N4IPA in mice bearing S180 tumor demonstrated that the complex showed accumulation in tumor and slow clearance from it. The tumor-to-tissue uptake ratios increase with time. These results suggest that 99mTc-N4IPA would be a marker for imaging tumor hypoxia.
Chu
Taiwei
T
Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Hu
Shaowen
S
Wei
Bing
B
Wang
Yi
Y
Liu
Xinqi
X
Wang
Xiangyun
X
D000818:Animals; D015687:Cell Hypoxia; D008297:Male; D051379:Mice; D009593:Nitroimidazoles / Q000138:chemical synthesis; D015609:Organotechnetium Compounds / Q000138:chemical synthesis; D011877:Radionuclide Imaging; D012510:Sarcoma 180 / Q000000981:diagnostic imaging*; D014018:Tissue Distribution
D009593:Nitroimidazoles; D015609:Organotechnetium Compounds; C052587:4-nitroimidazole