title: Statistical epidemiological screening methods assessing certain biochemical markers.
abstract: The epidemiological studies have shown that it is difficult to define a "normal" value for the serum concentration of some biochemical markers with predictive significance for cardiovascular diseases (CVDs) as follows: total cholesterol (TC), total lipids (TL), triglycerides (TG), glycemia (G), and urea (U). Our study establishes the mean and limit values of the normality for the above mentioned markers, in an adult population from the Iaşi City, using the epidemiological screening method. The employed methodology includes the records of the results of 2788 biochemical determinations during a period of 5 years, in order to assess the state of health of the population, as well the data working up and interpretation by means of the EpiInfo computer program. By testing a series of "normal" limits, the values found with apparent healthy persons (n = 2691) and persons previously diagnosed with diabetes mellitus or CVDs (n = 97) were analyzed in a differentiated way. In the sample of apparent healthy individuals, with the age between 20 and up to 60, the mean values were: 210 mg% for TC; 6.74 g@1000--TL; 125.74 mg%--TG; 0.91 g%--G and 0.34 g%--U. Satisfactory correlations (correlation coefficient-"r") of age with the values of TC (r = 0.38); TG (r = 0.26) and G (r = 0.23) comparatively with U (r = 0.15) or TL (r = 0.14) were noticed. The comparison of the mean values between males and females did not reveal a significant difference (p > 0.05) for any of the assessed constants. The clinical and community studies of the CVD risk assessed in the Iaşi City area will have to be referred to the registered and analyzed values of this epidemiological screening in the interpretation of some biochemical markers data.
authors.affiliation: Department of Epidemiology, School of Medicine, University of Medicine and Pharmacy Gr.T. Popa, Iaşi.
authors.forename: Doina
authors.initials: D
authors.lastname: Azoicăi
authors.forename: L V
authors.initials: LV
authors.lastname: Boiculese
authors.forename: C
authors.initials: C
authors.lastname: Rezuş
authors.forename: Mihaela
authors.initials: M
authors.lastname: Perjoiu
authors.forename: A
authors.initials: A
authors.lastname: Ivan
mesh_terms: D000328:Adult; D000465:Algorithms; D015415:Biomarkers / Q000097:blood*; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control; D002784:Cholesterol / Q000097:blood*; D003625:Data Collection; D005260:Female; D005947:Glucose / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D012383:Romania / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood; D014508:Urea / Q000097:blood
chemical_list: D015415:Biomarkers; D008055:Lipids; D014280:Triglycerides; D014508:Urea; D002784:Cholesterol; D005947:Glucose