Melting of complexes of DNA-cis-DDP in acidic environment.
The peculiarities of helix-coil transition of DNA at complex-formation with cis-diamminedichlorplatinum (II) (cis-DDP) have been investigated in acidic environment by UV absorbance technique. It is shown that observed features of behavior T (pH) and T(m) (pH) DNA at pH 2.8-3.0 are possible to explain by formation in DNA of pseudo-ring structures at covalent linking of cis-DDP with DNA.
Dalyan
Y B
YB
Department of Molecular Physics of the Physical Faculty, 375025 Yerevan, Alek Manoogian St., 1, Armenia.
Haroutiunian
T S
TS
Haroutiunian
S G
SG
Vardevanyan
P O
PO
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism; D002417:Cattle; D002945:Cisplatin / Q000737:chemistry* / Q000378:metabolism*; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D009691:Nucleic Acid Denaturation; D044366:Transition Temperature
D000970:Antineoplastic Agents; D004247:DNA; D002945:Cisplatin