[Aldosterone].
Nonepithelial effect of aldosterone has been recognized as a cardiovascular risk factor independent of elevation of blood pressure. Pro-inflammatory effect of aldosterone in vasculature appears to be an initiating event for the target organ injuries. Recent clinical trials of aldosterone receptor blockers in congestive heart failure indicate the efficacy of aldosterone antagonism to prevent cardiac death. In addition to elevated plasma levels of aldosterone, mineralocorticoid receptor expression in cardiovascular tissues may contribute to the progression of heart failure. In this review, emerging role of aldosterone as a cardiovascular risk is highlighted.
Miyamori
Isamu
I
Third Department of Internal Medicine, Fukui Medical School.
D000450:Aldosterone / Q000502:physiology*; D000818:Animals; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D018161:Receptors, Mineralocorticoid / Q000187:drug effects
D018161:Receptors, Mineralocorticoid; D000450:Aldosterone