title: Microarray-based gene expression profiling in pancreatic ductal carcinoma: status quo and perspectives.
abstract: BACKGROUND
  Pancreatic ductal adenocarcinoma has an extremely poor prognosis. To improve the prognosis, novel molecular markers and targets for earlier diagnosis and adjuvant and/or neoadjuvant treatment need to be identified. One of the key techniques that has been developed to achieve this goal is DNA microarray profiling, which is used to identify the mechanisms of deregulated molecular functions in pancreatic carcinoma cells.
  
  
  OBJECTIVE
  As several studies using microarrays have already been published, this review attempts to compare published data and crossvalidate the results. In addition, the applied techniques are discussed.
authors.affiliation: Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technical University of Dresden, Fetscherstrasse 74, Dresden, Germany. Robert.Gruetzmann@mailbox.tu-dresden.de
authors.forename: Robert
authors.initials: R
authors.lastname: Grützmann
authors.forename: Hans Detlev
authors.initials: HD
authors.lastname: Saeger
authors.forename: Jutta
authors.initials: J
authors.lastname: Lüttges
authors.forename: Hans Konrad
authors.initials: HK
authors.lastname: Schackert
authors.forename: Holger
authors.initials: H
authors.lastname: Kalthoff
authors.forename: Günter
authors.initials: G
authors.lastname: Klöppel
authors.forename: Christian
authors.initials: C
authors.lastname: Pilarsky
mesh_terms: D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D004273:DNA, Neoplasm / Q000032:analysis; D020869:Gene Expression Profiling; D006801:Humans; D020360:Neoadjuvant Therapy; D020411:Oligonucleotide Array Sequence Analysis; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000628:therapy; D011379:Prognosis
chemical_list: D004273:DNA, Neoplasm