title: Iodoamphetamine (IMP) uptake in the brain is increased after experimental cerebral venous hypertension in the rat.
abstract: Cerebral venous hypertension (VH) is a pathological condition associated with arteriovenous malformation, and is an important determinant factor for clinical symptom and outcome. Using a rat whole brain VH model created by a carotid-jugular fistula and contralateral jugular vein ligation we measured superior sagittal sinus pressure (SSSP) and cerebral blood flow (CBF) by the 14C-iodoamphetamine (IMP) indicator fractionation technique under isoflurane anesthesia with controlled ventilation. SSSP was significantly elevated in the fistula group (15 +/- 1 mmHg) (mean +/- SEM) compared to the vessel occlusion (5 +/- 1) and sham operated groups (5 +/- 1) (P < 0.05). Mean absolute CBF in the fistula (103 +/- 3 ml/ min/100 g) and vessel occlusion (90 +/- 4) groups were elevated compared to the sham group (77 +/- 3) (P < 0.05). Physiological parameters (mean blood pressure, heart rate, and blood gas analysis) before measurement were not different. In this VH model we found increases in SSSP and IMP uptake in the brain. We assume the mechanism of IMP uptake increase in VH animal may be slow circulation with a possible change of first pass extraction of IMP.
authors.affiliation: Department of Neurosurgery, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. yamadam@med.kitasato-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: I
authors.initials: I
authors.lastname: Yuzawa
authors.forename: K
authors.initials: K
authors.lastname: Fujii
mesh_terms: D000662:Amphetamines / Q000493:pharmacokinetics*; D000818:Animals; D001164:Arteriovenous Fistula; D001166:Arteriovenous Shunt, Surgical; D001921:Brain / Q000378:metabolism*; D002339:Carotid Arteries / Q000601:surgery; D002550:Cerebral Veins; D002560:Cerebrovascular Circulation; D003392:Cranial Sinuses / Q000503:physiopathology; D006973:Hypertension / Q000378:metabolism* / Q000503:physiopathology; D007601:Jugular Veins / Q000601:surgery; D008026:Ligation; D011312:Pressure; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000662:Amphetamines; D019275:Radiopharmaceuticals; C041336:4-iodoamphetamine