title: Acquired nasal hyperresponsiveness aggravates antigen-induced rhinitis in the guinea pig.
abstract: Whether a state of nasal hyperresponsiveness influences antigen-induced biphasic nasal blockage and sneezing were examined using a guinea pig model of allergic rhinitis. Sensitized animals were challenged with an antigen, Japanese cedar pollen, once every week. Before the 13th challenge, the animals were randomly divided into 2 groups, and then the 13th challenge was performed (Groups A-0 and B-0). The 14th challenge was done on day 2 (Group A-2) and on day 7 (Group B-7) after the 13th challenge, on which nasal hyperresponsiveness was present and absent, respectively. Biphasic nasal blockage and sneezing after the challenge in Group A-2 were more severe than those in Group A-0, while those of Group B-7 were almost the same as those of Group B-0. An anti-histaminic, mepyramine, inhibited sneezing but not the biphasic nasal blockage in Group B-7. A cysteinyl leukotriene (CysLT) antagonist, pranlukast, suppressed the late nasal blockage but not the early blockage and sneezing in Group B-7. In contrast, in Group A-2, mepyramine significantly attenuated not only sneezing but also the early nasal blockage. Pranlukast significantly inhibited both nasal blockage and sneezing in Group A-2. In conclusion, nasal hyperresponsiveness aggravated the antigen-induced nasal responses, to which histamine and CysLTs considerably contributed.
authors.affiliation: Department of Pharmacology, Kyoto Pharmaceutical University, Yamaguchi, Japan.
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Mizutani
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takenaka
authors.forename: Shigekatsu
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000818:Animals; D000941:Antigens / Q000008:administration & dosage / Q000276:immunology*; D002867:Chromones / Q000494:pharmacology; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D020024:Leukotriene Antagonists / Q000494:pharmacology; D008297:Male; D009296:Nasal Cavity / Q000187:drug effects / Q000276:immunology* / Q000503:physiopathology; D015508:Nasal Obstruction / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D011058:Pollen / Q000276:immunology; D011738:Pyrilamine / Q000494:pharmacology; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy / Q000276:immunology*; D012912:Sneezing / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
chemical_list: D000941:Antigens; D002867:Chromones; D006634:Histamine H1 Antagonists; D020024:Leukotriene Antagonists; D011738:Pyrilamine; C047681:pranlukast