title: Renal disease in the acquired immunodeficiency syndrome in north central Nigeria.
abstract: BACKGROUND
  The brunt of the human immunodeficiency virus infection/the acquired immunodeficiency syndrome is largely borne by communities in sub-Saharan Africa. We describe renal disease in Nigerians with the acquired immunodeficiency syndrome.
  
  
  METHODS
  Consecutive patients with the acquired immunodeficiency syndrome (AIDS) seen in the infections unit of the Jos University Teaching Hospital and a similar group of healthy controls were evaluated for renal disease. Subjects with past history of renal disease, hypovolemia, hypertension, diabetes mellitus and/or a documented fever were excluded from the study.
  
  
  RESULTS
  Of the 79 patients with the acquired immunodeficiency syndrome and 57 controls studied, renal disease was present in 41 (51.8%) of the patients in the AIDS group and 7 (12.2%) of controls. While 15 (19%) of the AIDS group had azotemia alone and 20 (25.3%) had proteinuria alone, 6 (7.6%) had azotemia and proteinuria. The mean protein excretion/24 hours was significantly higher in the AIDS group compared to controls, (2.99 +/- 54 g and 0.56 +/- 0.12 g respectively, p = 0.001), while the GFR was significantly higher in controls compared to the study group (103.30 +/- 37.78 and 68.03 +/- 37.55 respectively, p = 0.004). Subjects in the AIDS group with renal disease had a significantly longer duration of illness compared to those without (12.33 +/- 8.67 months and 7.28 +/- 7.78 months respectively, p = 0.008). Age and serum CD4+ cell counts were similar in patients with and without renal disease in the AIDS group.
  
  
  CONCLUSIONS
  Renal disease is a common complication of acquired immunodeficiency syndrome, the duration of illness being strongly associated with its presence.
authors.affiliation: Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria.
authors.forename: E I
authors.initials: EI
authors.lastname: Agaba
authors.forename: P A
authors.initials: PA
authors.lastname: Agaba
authors.forename: N D
authors.initials: ND
authors.lastname: Sirisena
authors.forename: E A
authors.initials: EA
authors.lastname: Anteyi
authors.forename: J A
authors.initials: JA
authors.lastname: Idoko
mesh_terms: D016263:AIDS-Associated Nephropathy / Q000453:epidemiology* / Q000276:immunology / Q000378:metabolism; D000328:Adult; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D009549:Nigeria / Q000453:epidemiology