Apparent magnesium absorption in dry cows fed at 3 levels of potassium and 2 levels of magnesium intake.
In vitro experiments with isolated rumen epithelium have shown that the relationship between the ruminal K concentration and either the apical membrane potential difference or the mucosal-to-serosal Mg flux reach plateau values at high ruminal K concentrations. Hence, it may be hypothesized that the inhibitory effect of supplemental K on Mg absorption becomes smaller at high initial K intakes. To test our hypothesis, 6 ruminally fistulated, nonpregnant dry cows were fed 6 experimental diets in a 6 x 6 Latin square design with a 2 x 3 factorial arrangement of treatments. Four cows were of a Friesian-Holstein x Holstein-Friesian cross, and the 2 remaining cows were of a Meuse-Rhine-IJssel x Holstein-Friesian cross. The diets provided either 40.6 or 69.1 g of Mg per day and contained 20.7, 48.0, or 75.5 g of K per kilogram of dry matter. The dietary variables were obtained by mixing KHCO(3) and MgO into the basal concentrate. Absorption of Mg and the urinary Mg excretion was significantly decreased by supplemental K and significantly increased after the intake of supplemental Mg. In contrast to apparent Mg absorption, the urinary excretion of Mg was not affected by the dietary K x Mg interaction. Postfeeding ruminal K and Mg concentrations were increased with increasing K and Mg intakes. Postfeeding ruminal K concentrations and the urinary excretion of Mg showed a linear negative correlation; the slope was not significantly affected by Mg intake. Therefore, our hypothesis was rejected. Furthermore, these data indicate that supplemental Mg can effectively counteract the suppressant effect of K on Mg absorption in cows.
Jittakhot
S
S
Department of Nutrition, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Schonewille
J T
JT
Wouterse
H
H
Yuangklang
C
C
Beynen
A C
AC
D000042:Absorption; D000818:Animals; D001835:Body Weight; D002417:Cattle / Q000378:metabolism*; D004032:Diet; D019587:Dietary Supplements; D004347:Drug Interactions; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000008:administration & dosage* / Q000032:analysis / Q000493:pharmacokinetics*; D017419:Potassium, Dietary / Q000008:administration & dosage*; D012044:Regression Analysis; D012417:Rumen / Q000737:chemistry / Q000378:metabolism
D017419:Potassium, Dietary; D008274:Magnesium