title: Synthesis of new 2,3-diaryl-1,3-thiazolidin-4-ones as anti-HIV agents.
abstract: Several 2,3-diaryl-1,3-thiazolidin-4-ones were synthesized and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of HIV-1 replication at 30-50 nM concentrations with minimal cytotoxicity, thereby acting as non-nucleoside HIV-1 reverse transcriptase inhibitors (NNRTIs).
authors.affiliation: Dipartimento Farmaco-Chimico, Università di Messina, viale Annunziata, 98168, Messina, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Rao
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.forename: Anna
authors.initials: A
authors.lastname: Carbone
authors.forename: Alba
authors.initials: A
authors.lastname: Chimirri
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Monforte
authors.forename: Pietro
authors.initials: P
authors.lastname: Monforte
authors.forename: Christophe
authors.initials: C
authors.lastname: Pannecouque
authors.forename: Maria
authors.initials: M
authors.lastname: Zappalà
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D004353:Drug Evaluation, Preclinical; D015497:HIV-1 / Q000187:drug effects / Q000254:growth & development; D015498:HIV-2 / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D015394:Molecular Structure; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects / Q000821:virology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D018894:Reverse Transcriptase Inhibitors; D013844:Thiazoles