Triptorelin versus cetrorelix in intracytoplasmic sperm injection cycles in women with a single ovary.
OBJECTIVE
To compare the response to ovarian stimulation with either the long protocol of a GnRH-agonist or the multiple protocol of a GnRH-antagonist, in women with a single ovary who underwent intracytoplasmic sperm injection (ICSI) cycles.


METHODS
Retrospective study including 75 ICSI cycles from 26 women. Sixty-three cycles were stimulated with triptorelin/hMG or rFSH, whereas 12 cycles were stimulated with cetrorelix/hMG or rFSH.


RESULTS
There was not found any statistical significant difference between the two groups regarding the days of stimulation, the number of gonadotropins' ampoules, the peak estradiol levels, the number of aspirated follicles and the number of retrieved oocytes. The fertilization rate, the number of transferred embryos as well as the cumulative embryo score were also similar in both groups.


CONCLUSIONS
The multiple stimulation protocol of cetrorelix is equally effective with the long protocol of triptorelin in the ovarian stimulation of women with a single ovary.
Nikolettos
N
N
Laboratory of Reproductive Physiology, Faculty of Medicine, Demokritus University of Thrace, Dragana, Hellas, 68100 Alexandroupolis, Greece.
Asimakopoulos
B
B
Diedrich
K
K
Al-Hasani
S
S
D000328:Adult; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects / Q000502:physiology; D010053:Ovary / Q000002:abnormalities*; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate / Q000639:trends*; D011336:Probability; D012189:Retrospective Studies; D012307:Risk Factors; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods*; D017329:Triptorelin Pamoate / Q000627:therapeutic use*
D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; C062876:cetrorelix