title: Coagulation inhibitors in preeclamptic pregnant women.
abstract: OBJECTIVE
  Our objective was to detect clinical evaluation of coagulation inhibitors in preeclamptic and normotensive pregnant women and to determine their important role in pathogenesis of preeclampsia.
  
  
  METHODS
  A total of 20 mild, 20 severe preeclamptic and 45 normotensive pregnant women were included in this study. The plasma value of antithrombin III (AT-III) activity, proteins C and S activity, PT, PTT, fibrinogen and platelet counts were determined.
  
  
  RESULTS
  The values AT-III were lower in women with severe preeclampsia than in controls (p<0.05). In all groups, there was no significantly difference in the concentration of protein C activity, protein S and fibrinogen (p>0.05). The plasma thrombocyte counts were significantly lower in severe preeclamptic women than in normotensive women (p<0.05). There was no significant difference in the prothrombin time value in all groups, but a significantly difference with regard to partial thromboplastin time between severe preeclamptic and the control group (p<0.0001). It was longer than the control.
  
  
  CONCLUSIONS
  The markers of hemostasis activation such as protein S, protein C activity together with fibrinogen levels are not useful tools but the reduction of AT-III and platelet counts would seem useful in different pathological situations in pregnancy to predict and monitor the severity of the condition.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey. osmanaga@meds.ktu.edu.tr
authors.forename: Mehmet A
authors.initials: MA
authors.lastname: Osmanağaoğlu
authors.forename: Kenan
authors.initials: K
authors.lastname: Topçuoğlu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozeren
authors.forename: Hasan
authors.initials: H
authors.lastname: Bozkaya
mesh_terms: D000328:Adult; D000990:Antithrombin III / Q000032:analysis; D001777:Blood Coagulation; D016022:Case-Control Studies; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D006973:Hypertension; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D011225:Pre-Eclampsia / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011486:Protein C / Q000032:analysis; D017293:Protein S / Q000032:analysis; D011517:Prothrombin Time
chemical_list: D011486:Protein C; D017293:Protein S; D000990:Antithrombin III; D005340:Fibrinogen