title: Intracellular proteoglycans.
abstract: Proteoglycans (PGs) are proteins with glycosaminoglycan chains, are ubiquitously expressed and have a wide range of functions. PGs in the extracellular matrix and on the cell surface have been the subject of extensive structural and functional studies. Less attention has so far been given to PGs located in intracellular compartments, although several reports suggest that these have biological functions in storage granules, the nucleus and other intracellular organelles. The purpose of this review is, therefore, to present some of these studies and to discuss possible functions linked to PGs located in different intracellular compartments. Reference will be made to publications relevant for the topics we present. It is beyond the scope of this review to cover all publications on PGs in intracellular locations.
authors.affiliation: Institute for Nutrition Research, University of Oslo, Box 1046 Blindern, 0316 Oslo, Norway. s.o.kolset@basalmed.uio.no
authors.forename: Svein Olav
authors.initials: SO
authors.lastname: Kolset
authors.forename: Kristian
authors.initials: K
authors.lastname: Prydz
authors.forename: Gunnar
authors.initials: G
authors.lastname: Pejler
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000737:chemistry; D004705:Endocytosis; D006025:Glycosaminoglycans / Q000737:chemistry; D006801:Humans; D008954:Models, Biological; D011509:Proteoglycans / Q000032:analysis / Q000737:chemistry / Q000502:physiology*; D022142:Secretory Vesicles / Q000737:chemistry
chemical_list: D006025:Glycosaminoglycans; D011509:Proteoglycans