[The life cycle of the GABA(A) receptor and its regulating molecules].
Gamma-aminobutyric acid(A) (GABA(A)) receptors mediate most of the fast inhibitory neurotransmission in the central nervous system. These ligand-gated ion channels are crucial in the control of cell and network activity. Therefore, modulating their function or cell surface stability will have major consequences for neuronal excitation. This review highlights recent findings on the regulation of GABA(A)-receptor expression and function, focusing on the mechanisms of sorting, targeting, synaptic clustering, and endocytic events of GABA(A) receptors, all which are regulated by their associated proteins. Now these topics are an area of active interest in studies on inhibitory neurotransmission.
Kanematsu
Takashi
T
Cellular and Molecular Biochemistry, Faculty of Dental Science and Station for Collaborative Research, Kyushu University, Fukuoka, Japan.
Terunuma
Miho
M
Goto
Hidefumi
H
Kuratani
Akiko
A
Hirata
Masato
M
D000818:Animals; D001921:Brain / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006801:Humans; D010766:Phosphorylation; D011963:Receptors, GABA-A / Q000096:biosynthesis / Q000378:metabolism / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
D002352:Carrier Proteins; D011963:Receptors, GABA-A