title: [Anatomical and functional abnormalities of central nervous system in autistic disorder: a MRI and SPECT study].
abstract: We present a study of anatomical and functional abnormalities of central nervous system (CNS) from patients with autistic disorder (AD); magnetic resonance imaging (MRI) and single photon emission computed tomography (SPECT) were used for the investigation. The population studied was composed of 24 patients, 15 (62.5%) males and 9 (17.5%) females, mean age 9 years. MRI was performed in all patients and SPECT was performed in 19 patients; 75% (n=18) of patients had anatomical abnormalities and all patients that realized SPECT had functional abnormalities. Anatomical abnormalities were preferentially noted in corpus callosum (25%), septum pellucidum (15.63%), cerebral ventricles (12.55%), cerebellum (9.38%), temporal lobes (6.25%), occipital lobes (6.25%) and hippocampus (6.25%). Functional abnormalities predominated in frontal lobes (53.13%), temporal lobes (28.13%), parietal lobes (15.63%) and basal ganglia (3.13%). However, anatomical and functional abnormalities of CNS are not priorities for diagnosis, which should have always clinical validation.
authors.affiliation: Serviço de Neurologia, Hospital Universitário, Universidade Federal de Sergipe, Aracaju, SE, Brasil. marbenguedes@uol.com.br
authors.forename: Marbene Guedes
authors.initials: MG
authors.lastname: Machado
authors.forename: Hélio Araújo
authors.initials: HA
authors.lastname: Oliveira
authors.forename: Rosana
authors.initials: R
authors.lastname: Cipolotti
authors.forename: Clara Augusta Garcia Moreno
authors.initials: CA
authors.lastname: Santos
authors.forename: Emanoella Faro
authors.initials: EF
authors.lastname: de Oliveira
authors.forename: Robert Moraes
authors.initials: RM
authors.lastname: Donald
authors.forename: Miriam Peres de Oliveira
authors.initials: MP
authors.lastname: Krauss
mesh_terms: D000293:Adolescent; D000328:Adult; D061085:Agenesis of Corpus Callosum; D001321:Autistic Disorder / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000503:physiopathology; D001921:Brain / Q000002:abnormalities / Q000000981:diagnostic imaging* / Q000473:pathology*; D002531:Cerebellum / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015899:Tomography, Emission-Computed, Single-Photon