[Characteristics of pyrrolidone pharmacokinetics in rats].
The pharmacokinetics of pyrrolidone in a composition with pyroglutamic acid was studied in white mongrel male rats. The former component exhibits cerebrovascular and neuroprotector activity. Pyrrolidone, detected in the blood plasma and brain for 8 h after peroral and intravenous administration, exhibits a high absolute bioavailability and the ability to penetrate via the blood-brain barrier.
Sariev
A K
AK
Laboratory of Pharmacokinetics, Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Lun'shina
E V
EV
Zherdev
V P
VP
D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000378:metabolism; D007275:Injections, Intravenous; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011760:Pyrrolidinones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D014018:Tissue Distribution
D018696:Neuroprotective Agents; D011760:Pyrrolidinones