[Effects of treatment with redox agent, blood transfusion and scopolamine on 200 patients with severe chlorphenamidine poisoning].
OBJECTIVE
To verify the effects of treatment with blood transfusion and scopolamine on severe chlorphenamidine poisoning (SCP).


METHODS
400 patients with severe oral chlorphenamidine poisoning were randomly divided into two groups. 200 patients (Group I) were treated with the traditional combined therapy including gastrolavage, purgation and taking redox agent (methylene blue and vitamin C) while the other 200 patients (Group II) in addition to the above mentioned therapy, received blood transfusion and scopolamine injection.


RESULTS
The cure rate of Group II was 99.5% and significantly higher than that of Group I (91.0%, P < 0.01). The average time of improving in health in Group II [(8.71 +/- 1.49) h] was obviously shorter than those in Group I [(10.65 +/- 1.72) h, P < 0.01]. Blood methemoglobin concentrations in Group II at 3, 7, 12, 24 h after admission [(43.58 +/- 2.69), (34.21 +/- 2.30), (20.60 +/- 4.03), (13.50 +/- 1.65) g/L respectively] were obviously lower than those in Group I [(54.42 +/- 12.79), (42.17 +/- 22.34), (30.66 +/- 17.67), (19.01 +/- 0.61) g/L respectively, P < 0.01].


CONCLUSIONS
Blood transfusion and scopolamine had distinctive therapeutic effect on SCP to makeup the deficiency of redox agent. Combination of three therapies may potentiate the detoxication for chlorphenamidine.
He
Ren-hui
RH
The Traditional Chinese Medical Hospital of Jingzhou District, Jingzhou, Hubei Province 434100, China.
Du
Jie
J
Yang
Bao-xian
BX
Liu
Ben-wu
BW
Duan
Chang-feng
CF
Hu
Zhang-liang
ZL
Bai
Yu-peng
YP
D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D001803:Blood Transfusion; D002742:Chlorphenamidine / Q000506:poisoning*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D009184:Mydriatics / Q000627:therapeutic use; D011041:Poisoning / Q000628:therapy*; D012601:Scopolamine / Q000627:therapeutic use*; D016896:Treatment Outcome
D000975:Antioxidants; D007306:Insecticides; D009184:Mydriatics; D012601:Scopolamine; D002742:Chlorphenamidine