title: [Heparin-surface-modified PMMA intraocular lenses in children in early and late follow-up].
abstract: OBJECTIVE
  To compare anatomical and functional state of eyeballs after congenital cataract extraction and heparin-surface-modified PMMA (HSM-PMMA) or PMMA implanted lenses and to conclude, which type of implants is more advantageous in young patients.
  
  
  METHODS
  42 eyes of 30 children at the age of 3-16 years with congenital or developmental cataract after extraction and IOL implantation: I group--HSM-PMMA lenses in 24 eyes, and PMMA lenses in 18 eyes--II group. Mean age in the I group was 6 years and in the II group 8 years, p = 0.07. The presence of cellular and pigment deposits on the IOL surface as a sign of postoperative inflammation was examined by slit-lamp within 1 month after surgery. We have compared the results of visual acuity (V/A), corneal endothelium cell density and posterior capsule state. The examination were done in the short-term follow-up mean 14.1 months (4-24 months) in the I group and mean 32.1 months (16-48 months) in the II group. In the long-term follow-up mean 38 months (30-44 months) in the I group, and mean 56.1 months (40-72 months) in the II group.
  
  
  RESULTS
  Within first month after operation cellular and pigment deposits on the IOL surface were seen more often in the II group, p = 0.03. Best corrected V/A was comparable in both groups in the short-term and the long-term follow-up. At last visit, mean value of V/A was 0.54 (I group) and 0.42 (II group), p = 0.37. There was no significant difference between central corneal endothelial cell density in both groups: before (2893 +/- 261/mm2 and 2821 +/- 217/mm2, p = 0.143) and after operation (2371 +/- 202/mm2 and 2361 +/- 299/mm2, p = 0.428). In the short-term follow-up, but not longer than within first 12 months after surgery the frequency of clinically significant posterior capsule opacification (PCO) was less in the HSM-PMMA group (8%), than in the PMMA group (33%), p = 0.006. In the long-term follow-up there was no statistically significant difference in PCO appearance between these groups (44% and 50%, p = 0.27).
  
  
  CONCLUSIONS
  Heparin-surface-modified intraocular lenses reduced postoperative inflammation and delayed the incidence of PCO in children. Heparin-surface-modified intraocular lenses are more advantageous, than PMMA lenses in young patients.
authors.affiliation: Katedra i Klinika Okulistyki Dzieciecej Slaskiej Akademii Medycznej w Katowicach.
authors.forename: Bronisława
authors.initials: B
authors.lastname: Koraszewska-Matuszewska
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Samochowiec-Donocik
authors.forename: Ewa
authors.initials: E
authors.lastname: Pieczara
authors.forename: Erita
authors.initials: E
authors.lastname: Filipek
mesh_terms: D002386:Cataract / Q000628:therapy*; D002387:Cataract Extraction / Q000379:methods; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006493:Heparin; D006801:Humans; D019654:Lens Implantation, Intraocular; D008297:Male; D011182:Postoperative Care; D011300:Preoperative Care
chemical_list: D006493:Heparin