Plasticity of T cell memory responses to viruses.
Virus-specific memory T cell populations demonstrate plasticity in antigenic and functional phenotype, in recognition of antigen, and in their ability to accommodate new memory T cell populations. The adaptability of complex antigen-specific T cell repertoires allows the host to respond to a diverse array of pathogens and accommodate memory pools to many pathogens in a finite immune system. This is in part accounted for by crossreactive memory T cells, which can be employed in immune responses and mediate protective immunity or life-threatening immunopathology.
Selin
Liisa K
LK
Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.
Welsh
Raymond M
RM
D000818:Animals; D003429:Cross Reactions / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology / Q000502:physiology*; D009980:Influenza A virus / Q000276:immunology; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology; D051379:Mice; D018146:Muromegalovirus / Q000276:immunology; D010641:Phenotype; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*; D014777:Virus Diseases / Q000276:immunology*
D011948:Receptors, Antigen, T-Cell