Aldose reductase: a key player in myocardial ischemic injury.
In the search for increasing effectiveness of reperfusion therapy, the authors demonstrate that the polyol pathway enzyme aldose reductase is a key component of myocardial ischemic injury and that inhibitors of this enzyme limit ischemic injury and improve functional recovery on reperfusion.
Kaneko
Michiyo
M
Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA.
Ramasamy
Ravichandran
R
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D017202:Myocardial Ischemia / Q000201:enzymology* / Q000503:physiopathology*; D009204:Myocardial Revascularization / Q000379:methods; D015427:Reperfusion Injury / Q000517:prevention & control; D018570:Risk Assessment; D012680:Sensitivity and Specificity
D004791:Enzyme Inhibitors; D000449:Aldehyde Reductase