Very general formation of tetrahydropterin cation radicals during reaction of iron porphyrins with tetrahydropterins: model for the corresponding NO-synthase reaction.
Electron transfer from tetrahydropterins to iron porphyrins, with formation of intermediate tetrahydropterin cation radicals, is a very general reaction that was shown to occur not only with tetrahydrobiopterin, as originally found in NO-synthases, but also with another important biological cofactor, tetrahydrofolate, and various iron porphyrins, either in their ferric state, or in the Fe(II)O(2) state, as in the first model of the corresponding NO-synthase reaction described in this paper.
Mathieu
Delphine
D
UMR 8601, Université Paris V, 45 rue des Saints-Pères, 75270 PARIS Cedex 06, France.
Frapart
Yves-Michel
YM
Bartoli
Jean François
JF
Boucher
Jean-Luc
JL
Battioni
Pierrette
P
Mansuy
Daniel
D