Class 1 integron containing metallo-beta-lactamase gene blaVIM-2 in Pseudomonas aeruginosa clinical strains isolated in Japan.
Four bla(VIM-2) gene-harboring Pseudomonas aeruginosa strains were identified. These strains possessed a class 1 integron harboring ORF1, bla(VIM-2), and aacA4 gene cassettes. The transposon-mediated horizontal spread of the bla(VIM-2) gene among these strains was suggested, which increases the threat that the bla(VIM-2) gene will disseminate among diverse genera of bacteria.
Yatsuyanagi
Jun
J
Akita Prefectural Institute of Public Health, 6-6 Sensyu kubota-machi, Akita 010-0874, Japan. jyatsu@spica.freemail.ne.jp
Saito
Shioko
S
Harata
Seizaburo
S
Suzuki
Noriyuki
N
Ito
Yuko
Y
Amano
Ken-Ichi
K
Enomoto
Katsuhiko
K
D015139:Blotting, Southern; D004251:DNA Transposable Elements / Q000235:genetics; D022761:Gene Transfer, Horizontal; D005798:Genes, Bacterial / Q000235:genetics; D006801:Humans; D032023:Integrons / Q000235:genetics*; D007564:Japan; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
D004251:DNA Transposable Elements; D011506:Proteins; C425108:beta-lactamase bla(vim-2); D001618:beta-Lactamases