IL-6 trans-signaling: the heat is on.
The molecular consequence of the fever response has been illuminated by a recent study showing that a temperature shift to 40 degrees C resulted in increased leukocyte adhesion to tissue sections, which was mediated by L-selectin activation in lymphocytes. This L-selectin activation during heat responses was dependent on IL-6 trans-signaling via the soluble IL-6R.
Rose-John
Stefan
S
Department of Biochemistry, Christian-Albrechts-Universität zu Kiel, Olshausenstrasse 40, D-24098, Kiel, Germany.
Neurath
Markus F
MF
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D006358:Hot Temperature; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology*; D019041:L-Selectin / Q000502:physiology; D008214:Lymphocytes / Q000502:physiology*; D051379:Mice; D019947:Receptors, Interleukin-6 / Q000097:blood / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D015850:Interleukin-6; D019947:Receptors, Interleukin-6; D019041:L-Selectin