title: Endovascular coil occlusion of 1811 intracranial aneurysms: early angiographic and clinical results.
abstract: OBJECTIVE
  We sought to evaluate the early angiographic and clinical outcomes of the first session of endovascular coil occlusion of a large number of patients with intracranial aneurysms treated by five neurointerventionalists during a decade at a single center.
  
  
  METHODS
  We performed retrospective analyses of pre- and postprocedural angiographic studies and early clinical outcomes. Enrolled patients underwent endovascular treatment of intracranial aneurysms with detachable coils.
  
  
  RESULTS
  A total of 1811 aneurysms in 1579 patients were treated with coil occlusion. Of these, 90 to 100% occlusion of 86.5% of the aneurysms was achieved. In 82.3% of the procedures, no complications occurred. The clinical outcome profile at primary discharge according to the Glasgow Outcome Scale was as follows: Grade V, 74.6%; Grade IV, 6.7%; Grade III, 11.1%; Grade II, 3.1%; and Grade I, 4.5%. In patients with large aneurysms with wide necks, a lower occlusion rate and an increased complication rate were encountered. The use of three-dimensional and fibered coils resulted in higher occlusion rates. Balloon remodeling and stent deployment increased the complication rate. Previous aneurysm rupture, procedural complications, and vasospasm correlated with poor outcome. Of the patients in poor grade after aneurysm rupture, 42% recovered to Glasgow Outcome Scale Grade IV or V, as opposed to 90% of patients who were treated for unruptured aneurysms. The ischemic complication rate was 9%, and the hemorrhagic complication rate was 3%. The early procedural morbidity rate was 5.3%, and the procedural mortality rate was 1.5%. The management mortality rate was 4.4%.
  
  
  CONCLUSIONS
  These data confirm the safety and efficacy of endovascular coil occlusion for patients with intracranial aneurysms.
authors.affiliation: Klinik für Radiologie und Neuroradiologie, Alfried Krupp Krankenhaus, Alfried Krupp Strasse 21, D-45117 Essen, Germany. HHHenkes@aol.com
authors.forename: Hans
authors.initials: H
authors.lastname: Henkes
authors.forename: Sebastian
authors.initials: S
authors.lastname: Fischer
authors.forename: Werner
authors.initials: W
authors.lastname: Weber
authors.forename: Elina
authors.initials: E
authors.lastname: Miloslavski
authors.forename: Stephan
authors.initials: S
authors.lastname: Felber
authors.forename: Stefan
authors.initials: S
authors.lastname: Brew
authors.forename: Dietmar
authors.initials: D
authors.lastname: Kuehne
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017130:Angioplasty / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004621:Embolization, Therapeutic / Q000009:adverse effects* / Q000295:instrumentation; D005260:Female; D006801:Humans; D007223:Infant; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000628:therapy*; D007431:Intraoperative Complications; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011859:Radiography; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome