Destructive joint disease in alpha-mannosidosis. A case report and review of the literature.
Storage of oligosaccharides due to a deficiency of alpha-mannosidase can lead to joint destruction in children and young adults. Treating hip destruction with a prosthesis might be successful in some of these patients, although diminished bone quality increases the risk of loosening of the prosthesis.
Gerards
A H
AH
Slotervaartziekenhuis, VU Medical Centre, Amsterdam, The Netherlands. agerards@SSVZ.nl
Winia
W P C A
WP
Westerga
J
J
Dijkmans
B A C
BA
van Soesbergen
R M
RM
D000328:Adult; D019644:Arthroplasty, Replacement, Hip; D001853:Bone Marrow / Q000473:pathology; D005260:Female; D005487:Foam Cells / Q000473:pathology; D006621:Hip Joint / Q000000981:diagnostic imaging / Q000473:pathology; D006622:Hip Prosthesis; D006801:Humans; D007592:Joint Diseases / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D011859:Radiography; D013583:Synovial Membrane / Q000473:pathology; D043323:alpha-Mannosidase / Q000378:metabolism; D008363:alpha-Mannosidosis / Q000150:complications* / Q000473:pathology / Q000601:surgery
D043323:alpha-Mannosidase