title: Improved model of multicomponent adsorption in reversed-phase liquid chromatography.
abstract: This work presents a modification to the real adsorbed solution model using a Flory-Huggins type of expression that was reported previously. This modification consists in replacing the Flory-Huggins activity coefficient by the spreading pressure dependent approach. This new model takes into account explicitly the adsorbate-adsorbate interactions taking place in the adsorbed phase. It provides an excellent prediction of the competitive, ternary adsorption equilibrium of benzyl alcohol, 2-phenylethanol and 2-methyl benzyl alcohol observed in a reversed-phase liquid chromatographic system using information merely derived from the single-component adsorption experimental data.
authors.affiliation: Departamento de Desarrollo Tecnológico, Centro de Química Farmacéutica (CQF), Calle 200 y 21, Apdo. 16042, Atabey, Playa, La Habana, Cuba.
authors.forename: Jorge E
authors.initials: JE
authors.lastname: Garcia-Galdo
authors.forename: José
authors.initials: J
authors.lastname: Cobas-Rodriguez
authors.forename: Ulises J
authors.initials: UJ
authors.lastname: Jáuregui-Haza
authors.forename: Georges
authors.initials: G
authors.lastname: Guiochon
mesh_terms: D000327:Adsorption; D002853:Chromatography, Liquid / Q000379:methods*