Starvation response in mouse liver shows strong correlation with life-span-prolonging processes.
We have monitored global changes in gene expression in mouse liver in response to fasting and sugar-fed conditions using high-density microarrays. From approximately 20,000 different genes, the significantly regulated ones were grouped into specific signaling and metabolic pathways. Striking changes in lipid signaling cascade, insulin and dehydroepiandrosterone (DHEA) hormonal pathways, urea cycle and S-adenosylmethionine-based methyl transfer systems, and cell apoptosis regulators were observed. Since these pathways have been implicated to play a role in the aging process, and since we observe significant overlap of genes regulated upon starvation with those regulated upon caloric restriction, our analysis suggests that starvation may elicit a stress response that is also elicited during caloric restriction. Therefore, many of the signaling and metabolic components regulated during fasting may be the same as those which mediate caloric restriction-dependent life-span extension.
Bauer
Matthias
M
Institut fuer Genetik, Forschungszentrum Karlsruhe, 76021 Karlsruhe, , Germany.
Hamm
Anne C
AC
Bonaus
Melanie
M
Jacob
Andrea
A
Jaekel
Jens
J
Schorle
Hubert
H
Pankratz
Michael J
MJ
Katzenberger
Joerg D
JD
D018528:ATP-Binding Cassette Transporters / Q000096:biosynthesis / Q000235:genetics; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D000090702:Constitutive Androstane Receptor; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000235:genetics; D003687:Dehydroepiandrosterone / Q000378:metabolism; D005215:Fasting / Q000378:metabolism*; D005223:Fats / Q000378:metabolism; D020869:Gene Expression Profiling; D008099:Liver / Q000378:metabolism*; D008136:Longevity / Q000502:physiology*; D008297:Male; D008780:Methyltransferases / Q000096:biosynthesis / Q000235:genetics; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear / Q000096:biosynthesis / Q000235:genetics; D011987:Receptors, Steroid / Q000096:biosynthesis / Q000235:genetics; D012436:S-Adenosylmethionine / Q000378:metabolism; D013002:Somatomedins / Q000378:metabolism; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics; D014508:Urea / Q000378:metabolism
D018528:ATP-Binding Cassette Transporters; D000596:Amino Acids; D002352:Carrier Proteins; D000090702:Constitutive Androstane Receptor; D005223:Fats; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D013002:Somatomedins; D014157:Transcription Factors; D003687:Dehydroepiandrosterone; D012436:S-Adenosylmethionine; D014508:Urea; D003577:Cytochrome P-450 Enzyme System; D002784:Cholesterol; D008780:Methyltransferases