[Preclinical study of maxar safety].
The results of preclinical safety evaluation of the new hepatoprotector maxar showed that this drug can be classified as a low-toxicity substance with respect to acute toxicity. No significant functional and structural changes in the systems and organs of experimental animals were observed after a 6-month administration in rats (in a dose of 300, 600, and 1200 mg/kg) and in dogs (500 mg/kg). Maxar exhibited no mutagen and allergen properties, produced no immunotoxicant action, and did not adversely affect the reproduction function.
Saratikov
A S
AS
Pharmacology Department, Siberian Medical University, Moskovskii trakt 2, Tomsk, 634050 Russia. albert@post.tomica.ru
Livshits
N S
NS
Burchenkova
F I
FI
Kadychagova
N G
NG
Akhmedzhanov
R R
RR
Bashirova
L V
LV
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000485:Allergens / Q000633:toxicity; D000818:Animals; D004285:Dogs; D005260:Female; D005419:Flavonoids / Q000276:immunology / Q000633:toxicity*; D007529:Isoflavones / Q000276:immunology / Q000633:toxicity; D029901:Maackia; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D009152:Mutagenicity Tests; D010636:Phenols / Q000276:immunology / Q000633:toxicity*; D010936:Plant Extracts / Q000276:immunology / Q000633:toxicity; D059808:Polyphenols; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D013267:Stilbenes / Q000276:immunology / Q000633:toxicity; D023382:Toxicity Tests, Acute; D036401:Toxicity Tests, Chronic
D000485:Allergens; D005419:Flavonoids; D007529:Isoflavones; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D013267:Stilbenes