title: Development of malignant glioma 15 months after anterior temporal lobectomy in a patient with temporal lobe epilepsy.
abstract: We report a 36-year-old woman, who had previously undergone anterior temporal lobectomy for intractable temporal lobe seizures; fifteen months later, magnetic resonance (MR) images showed a space-occupying lesion in the temporal lobectomy cavity. After a second operation, a histopathological examination showed a grade III astrocytoma. The fortuitous co-occurrence of temporal lobe epilepsy and a tumour was suspected, but histopathological and immunohistochemical examination of original resected temporal lobe parenchyma did not show evidence of neoplasm. The patient had not undergone postoperative radiotherapy and had not experienced viral infections. We propose that two factors possibly associated with the development of glioma were chemical exposure from anticonvulsant agents and trauma from resection of the anterior temporal lobe during initial surgery.
authors.affiliation: Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan. mitchy@med.osaka-cu.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Morino
authors.forename: T
authors.initials: T
authors.lastname: Ichinose
authors.forename: Y
authors.initials: Y
authors.lastname: Terakawa
authors.forename: T
authors.initials: T
authors.lastname: Haba
authors.forename: K
authors.initials: K
authors.lastname: Wakasa
authors.forename: K
authors.initials: K
authors.lastname: Ohata
authors.forename: M
authors.initials: M
authors.lastname: Hara
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects; D001932:Brain Neoplasms / Q000209:etiology*; D004833:Epilepsy, Temporal Lobe / Q000601:surgery*; D005260:Female; D005910:Glioma / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D011183:Postoperative Complications; D013702:Temporal Lobe / Q000601:surgery*
chemical_list: D000927:Anticonvulsants