title: Cholecystokinin: possible mediator of fever and hypothermia.
abstract: Thermoregulatory effects of cholecystokinin (CCK) peptides are reviewed with special emphasis on two types of responses, that is hyperthermia (fever) and hypothermia. Central microinjection of CCK in rats induces a thermogenic response that can be attenuated by CCK-B receptor antagonists, but some authors observed a hypothermia. By contrast to its central fever-inducing effect, in rodents exposed to cold CCK-8 elicits a dose-dependent hypothermia on peripheral injection probably acting on CCK-A receptors. It is suggested that neuronal CCK may have a specific role in the development of hyperthermia, and endogenous CCK-ergic mechanisms could contribute to the mediation of fever. The possible role of CCK-ergic mediation in endotoxin (LPS) fever has revealed that while CCK-B receptors seem to be involved in the development of fever, the role of CCK-A receptors could be more complex. In particular, while rats lacking functional CCK-A receptors show an exaggerated fever response, this phenomenon may be associated with a trait different from the absence of this receptor set. The relationship between the putative CCK-ergic febrile mechanism and the established central PGE mediation needs further study.
authors.affiliation: Department of Pathophysiology, Faculty of Medicine, University of Pécs, H-7602 Pécs, P.O.B. 99, Hungary. zoltan.szelenyi@aok.pte.hu
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Szelényi
authors.forename: Miklós
authors.initials: M
authors.lastname: Székely
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Hummel
authors.forename: Márta
authors.initials: M
authors.lastname: Balaskó
authors.forename: Andrej A
authors.initials: AA
authors.lastname: Romanovsky
authors.forename: Erika
authors.initials: E
authors.lastname: Pétervári
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000503:physiopathology; D002766:Cholecystokinin / Q000502:physiology*; D005334:Fever / Q000378:metabolism*; D006801:Humans; D007035:Hypothermia / Q000378:metabolism*; D051381:Rats
chemical_list: D002766:Cholecystokinin