title: Synthesis and biological evaluation of (-)-laulimalide analogues.
abstract: Analogues of the marine natural product (-)-laulimalide were prepared by total synthesis and evaluated in vitro for anticancer activity.
authors.affiliation: Eisai Research Institute, 100 Research Drive, Wilmington, MA 01887, USA. brian_gallagher@eri.eisai.com
authors.forename: Brian M
authors.initials: BM
authors.lastname: Gallagher
authors.forename: Francis G
authors.initials: FG
authors.lastname: Fang
authors.forename: Charles W
authors.initials: CW
authors.lastname: Johannes
authors.forename: Marc
authors.initials: M
authors.lastname: Pesant
authors.forename: Martin R
authors.initials: MR
authors.lastname: Tremblay
authors.forename: Hongjuan
authors.initials: H
authors.lastname: Zhao
authors.forename: Kozo
authors.initials: K
authors.lastname: Akasaka
authors.forename: Xiang-yi
authors.initials: XY
authors.lastname: Li
authors.forename: Junke
authors.initials: J
authors.lastname: Liu
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Littlefield
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D018942:Macrolides; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D043823:Taxoids / Q000138:chemical synthesis* / Q000737:chemistry; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D018942:Macrolides; D043823:Taxoids; C117305:laulimalide