The correspondence between equilibrium biphasic and triphasic material properties in mixture models of articular cartilage.
Mixture models have been successfully used to describe the response of articular cartilage to various loading conditions. Mow et al. (J. Biomech. Eng. 102 (1980) 73) formulated a biphasic mixture model of articular cartilage where the collagen-proteoglycan matrix is modeled as an intrinsically incompressible porous-permeable solid matrix, and the interstitial fluid is modeled as an incompressible fluid. Lai et al. (J. Biomech. Eng. 113 (1991) 245) proposed a triphasic model of articular cartilage as an extension of their biphasic theory, where negatively charged proteoglycans are modeled to be fixed to the solid matrix, and monovalent ions in the interstitial fluid are modeled as additional fluid phases. Since both models co-exist in the cartilage literature, it is useful to show how the measured properties of articular cartilage (the confined and unconfined compressive and tensile moduli, the compressive and tensile Poisson's ratios, and the shear modulus) relate to both theories. In this study, closed-form expressions are presented that relate biphasic and triphasic material properties in tension, compression and shear. These expressions are then compared to experimental findings in the literature to provide greater insight into the measured properties of articular cartilage as a function of bathing solutions salt concentrations and proteoglycan fixed-charge density.
Ateshian
Gerard A
GA
Departments of Mechanical Engineering and Biomedical Engineering, Columbia University, New York, NY10027, USA. ateshian@columbia.edu
Chahine
Nadeen O
NO
Basalo
Ines M
IM
Hung
Clark T
CT
D000818:Animals; D002356:Cartilage / Q000502:physiology*; D002358:Cartilage, Articular / Q000502:physiology*; D045424:Complex Mixtures / Q000502:physiology; D019245:Compressive Strength / Q000502:physiology; D003198:Computer Simulation; D004548:Elasticity; D005109:Extracellular Matrix / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D044367:Phase Transition; D016062:Porosity; D011509:Proteoglycans / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D013718:Tensile Strength / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000502:physiology*; D016474:Weight-Bearing / Q000502:physiology*
D045424:Complex Mixtures; D011509:Proteoglycans