title: Cardiac autonomic activity in methylmercury neurotoxicity: 14-year follow-up of a Faroese birth cohort.
abstract: OBJECTIVE
  To determine whether heart function in childhood is affected by exposure to methylmercury (MeHg) from seafood.
  
  
  METHODS
  Prospective study of a Faroese birth cohort (N=1022). Examinations at ages 7 and 14 years included blood pressure, heart rate variability (HRV) and its frequency components of autonomic origin, and brainstem auditory evoked potentials (BAEPs). Mercury concentrations were determined in cord blood and in the child's hair.
  
  
  RESULTS
  Both low-frequency (LF) and high-frequency (HF) activities decreased by about 25% from 7 to 14 years; they correlated well with the blood pressures. A doubling of prenatal MeHg exposure was associated with a decrease in LF and HF powers of about 6.7% (P=.04) and in the coefficient of variation of the electrocardiographic R-R interval of 2.7% (P=.04) at age 14 years. No discernible effect on blood pressure was apparent. Decreased LF variability was associated with increased latency of BAEP peak III, but adjustment for MeHg exposure substantially attenuated this correlation.
  
  
  CONCLUSIONS
  Methylmercury exposure was associated with decreased sympathetic (LF) and parasympathetic (HF) modulation of the HRV. Parallel MeHg-related delays of BAEP latencies may be caused by underlying MeHg neurotoxicity to brainstem nuclei.
authors.affiliation: Institute of Public Health, University of Southern Denmark, Odense, Denmark. pgrand@hsph.harvard.edu
authors.forename: Philippe
authors.initials: P
authors.lastname: Grandjean
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Murata
authors.forename: Esben
authors.initials: E
authors.lastname: Budtz-Jørgensen
authors.forename: Pál
authors.initials: P
authors.lastname: Weihe
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D002648:Child; D015331:Cohort Studies; D003718:Denmark; D004781:Environmental Exposure / Q000009:adverse effects; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D005506:Food Contamination; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D008767:Methylmercury Compounds / Q000633:toxicity*; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D017747:Seafood / Q000009:adverse effects*; D012737:Sex Factors; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology
chemical_list: D008767:Methylmercury Compounds