Lack of association between polymorphic variations in the alpha 3 subunit GABA receptor gene (GABRA3) and suicide attempts.
This is the first case-control study exploring the association between suicide attempts and the polymorphic variations of the alpha 3 subunit gamma-aminobutyric acid (GABA) receptor gene (GABRA3) located in chromosome X. In a Spanish general hospital, 184 suicide attempters (127 women and 57 men) and 275 control blood donors (109 women and 166 men) were recruited. The four frequent variants (A1, A2, A3 and A4) of GABRA3 were studied. There were no significant differences in the total or by-gender frequencies of the four alleles. In females, there were no significant differences in the genotypes. This study can rule out even small size effects in the total sample and suggests a lack of association between GABRA3 polymorphism and suicide attempt, in the Spanish population.
Baca-Garcia
Enrique
E
Department of Psychiatry, Fundacion Jimenez Diaz, Madrid, Spain.
Vaquero
Concepción
C
Diaz-Sastre
Carmen
C
Jimenez-Treviño
Luis
L
Saiz-Ruiz
Jeronimo
J
Fernández-Piqueras
José
J
de Leon
Jose
J
D000328:Adult; D000483:Alleles; D016009:Chi-Square Distribution; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D011963:Receptors, GABA-A / Q000235:genetics*; D013406:Suicide, Attempted
D011963:Receptors, GABA-A