title: No major effect of orciprenaline and propranolol upon ACTH-induced cortisol secretion.
abstract: Preclinical research suggests adrenal beta-adrenergic receptors to be involved in the regulation of steroid synthesis. In a group of healthy male volunteers, we compared ACTH-induced cortisol and dehydroepiandrosterone (DHEA) secretion after pre-treatment with orciprenaline, propranolol or placebo. Neither baseline nor ACTH-induced steroid secretion differed between these conditions. Our data do not support the hypothesis that the adrenal beta-receptor plays a major role in steroid secretion in humans.
authors.affiliation: Central Institute of Mental Health, Mannheim, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Nonell
authors.forename: S
authors.initials: S
authors.lastname: Kerk
authors.forename: F
authors.initials: F
authors.lastname: Lederbogen
authors.forename: D
authors.initials: D
authors.lastname: Kopf
authors.forename: B
authors.initials: B
authors.lastname: Hamann
authors.forename: S
authors.initials: S
authors.lastname: Lewicka
authors.forename: M
authors.initials: M
authors.lastname: Deuschle
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism / Q000502:physiology*; D000328:Adult; D003366:Cosyntropin / Q000378:metabolism; D003687:Dehydroepiandrosterone / Q000097:blood / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D008297:Male; D009921:Metaproterenol / Q000494:pharmacology*; D010913:Pituitary-Adrenal System / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D003366:Cosyntropin; D003687:Dehydroepiandrosterone; D009921:Metaproterenol; D000324:Adrenocorticotropic Hormone; D011433:Propranolol; D006854:Hydrocortisone