CSF lactate dehydrogenase activity in patients with Creutzfeldt-Jakob disease exceeds that in other dementias.
The diagnosis of Creutzfeldt-Jakob disease (CJD) is still made by exclusion of other dementias. We now evaluated lactate dehydrogenase (LDH) in the cerebrospinal fluid (CSF) as a possible additional diagnostic tool. CSF LDH levels of patients with CJD (n = 26) were compared with those in other dementias (n = 28). LDH isoenzymes were determined in a subset (n = 9). Total LDH and isoenzyme LDH-1 were significantly higher, whereas the fractions of LDH-2 and LDH-3 were significantly lower in CJD patients. We conclude that in addition to established CSF parameters, LDH and its isoenzymes might serve as a further help to discriminate between CJD and other dementias.
Schmidt
H
H
Department of Neurology, University of Göttingen, Göttingen, Germany. hschmid2@gwdg.de
Otto
M
M
Niedmann
P
P
Cepek
L
L
Schröter
A
A
Kretzschmar
H A
HA
Poser
S
S
D000368:Aged; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid* / Q000201:enzymology*; D003704:Dementia / Q000134:cerebrospinal fluid* / Q000201:enzymology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000134:cerebrospinal fluid; D007770:L-Lactate Dehydrogenase / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase