[Antimicrobial resistance of Helicobacter pylori: clinical and molecular aspects].
Helicobacter pylori is a relevant pathogen for gastroduodenal diseases in human beings. Although its eradication often improves gastroduodenal diseases, H pylori is acquiring an elevated rate of resistance to various antimicrobials, such as metronidazole, clarithromycin, tetracycline and amoxicillin. Multi-drug resistance is a major problem to select the appropriate treatment of infectious diseases. To improve our understanding on the complexity of the problem, in this article we review the resistance mechanisms and give an update on H pylori antimicrobial resistance.
Vallejos
Cristián
C
Facultad de Ciencias, Universidad de Chile.
Cerda
Oscar
O
Valenzuela
Manuel
M
Toledo
Héctor
H
D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology; D013754:Tetracyclines / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D013754:Tetracyclines; D008795:Metronidazole; D000658:Amoxicillin