title: Optical fiber probe for biomedical Raman spectroscopy.
abstract: In vitro experiments have demonstrated the ability of Raman spectroscopy to diagnose a wide variety of diseases. Recent in vivo investigations performed with optical fiber probes were promising but generally limited to easily accessible organs, often requiring relatively long collection times. We have implemented an optical design strategy to utilize system throughput fully by characterizing the Raman distribution from tissue. This scheme optimizes collection efficiency, minimizes noise, and has resulted in small-diameter, highly efficient Raman probes that are capable of collecting high-quality data in 1 s. Performance has been tested through simulations and experiments with tissue models and several in vitro tissue types, demonstrating that this new design can advance Raman spectroscopy as a clinically practical technique.
authors.affiliation: George R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Jason T
authors.initials: JT
authors.lastname: Motz
authors.forename: Martin
authors.initials: M
authors.lastname: Hunter
authors.forename: Luis H
authors.initials: LH
authors.lastname: Galindo
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Gardecki
authors.forename: John R
authors.initials: JR
authors.lastname: Kramer
authors.forename: Ramachandra R
authors.initials: RR
authors.lastname: Dasari
authors.forename: Michael S
authors.initials: MS
authors.lastname: Feld
mesh_terms: D001011:Aorta / Q000473:pathology; D001940:Breast / Q000473:pathology; D003198:Computer Simulation; D004867:Equipment Design; D005260:Female; D005336:Fiber Optic Technology; D006801:Humans; D008962:Models, Theoretical; D055100:Optical Fibers; D019047:Phantoms, Imaging; D013059:Spectrum Analysis, Raman / Q000295:instrumentation