title: Prion deposition in olfactory biopsy of sporadic Creutzfeldt-Jakob disease.
abstract: Currently, definite peripheral markers for the in vivo diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) are not available. Here, we report the presence of pathological prion protein in the olfactory mucosa of a case with sporadic Creutzfeldt-Jakob disease. Prion protein immunoreactivity was detected in an olfactory biopsy performed 45 days after the disease onset, suggesting that the involvement of olfactory epithelium is an early event in sporadic Creutzfeldt-Jakob disease.
authors.affiliation: Department of Neurosciences, University of Genoa, Genoa, Italy. mtabaton@neurologia.unige.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Tabaton
authors.forename: Salvatore
authors.initials: S
authors.lastname: Monaco
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Cordone
authors.forename: Monica
authors.initials: M
authors.lastname: Colucci
authors.forename: Giorgio
authors.initials: G
authors.lastname: Giaccone
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Tagliavini
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Zanusso
mesh_terms: D001706:Biopsy; D001923:Brain Chemistry; D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009831:Olfactory Mucosa / Q000378:metabolism* / Q000473:pathology; D018620:PrPSc Proteins / Q000378:metabolism*
chemical_list: D018620:PrPSc Proteins