title: Pathological effects on mice by gambierol, possibly one of the ciguatera toxins.
abstract: Gambierol was isolated from Gambierdiscus toxicus, which causes ciguatera fish poisoning. The acute toxicological effects induced in mice by synthesized gambierol were studied. The lethal doses were about 80 microg/kg by i.p. and i.v., and 150 microg/kg by p.o. The main injury by this toxin was observed in the lung, and secondary in the heart, resulting in systemic congestion. Another toxic effect was seen in the stomach, inducing hypersecretion and ulceration. With survival from the severe stage during the initial 3 h, recovery was favorable, especially after 4 days. Additional effects were not evident during 1-week post-administration observation.
authors.affiliation: Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8673, Japan. emiko@faculty.chiba-u.jp
authors.forename: Emiko
authors.initials: E
authors.lastname: Ito
authors.forename: Fumie
authors.initials: F
authors.lastname: Suzuki-Toyota
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Toshimori
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Fuwa
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tachibana
authors.forename: Masayuki
authors.initials: M
authors.lastname: Satake
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
mesh_terms: D000284:Administration, Oral; D000818:Animals; D036841:Ciguatera Poisoning; D002922:Ciguatoxins / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D004141:Dinoflagellida; D004195:Disease Models, Animal; D004988:Ethers, Cyclic / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009206:Myocardium / Q000473:pathology; D011083:Polycyclic Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D035964:Oxocins
chemical_list: D002922:Ciguatoxins; D004988:Ethers, Cyclic; D011083:Polycyclic Compounds; C435770:gambierol; D035964:Oxocins