Recombination: Holliday junction resolution and crossover formation.
The heterodimeric nuclease Mus81-Eme1 has been proposed to be a Holliday junction resolvase and has now been found to be responsible for nearly all meiotic crossovers in fission yeast. The intriguing substrate preference of this enzyme for nicked Holliday junctions opens the possibility that crossover formation may not always involve double Holliday junctions.
Heyer
Wolf Dietrich
WD
Division of Biological Sciences, Section of Microbiology and Center for Genetics and Development, University of California, Davis, California 95616-8665, USA. wdheyer@ucdavis.edu
D003434:Crossing Over, Genetic / Q000235:genetics*; D004249:DNA Damage / Q000235:genetics / Q000502:physiology; D004260:DNA Repair / Q000235:genetics / Q000502:physiology; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D004720:Endonucleases; D045565:Holliday Junction Resolvases / Q000235:genetics*; D008540:Meiosis / Q000235:genetics / Q000502:physiology*; D008957:Models, Genetic; D029701:Saccharomyces cerevisiae Proteins; D012568:Schizosaccharomyces
D004268:DNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins; D004720:Endonucleases; C411624:MUS81 protein, S cerevisiae; D045565:Holliday Junction Resolvases