[Insulin resistance in polycystic ovary syndrome].
With a prevalence of 5-10% the polycystic ovary syndrome (PCOS) is a common disorder of premenopausal women. According to prospective studies abnormal glucose tolerance and diabetes mellitus present in about 10.0% and 35.0% of adult women with PCOS, respectively. PCOS patients have a higher prevalence of cardiovascular risk factors such as hypertension and dyslipidaemia. The rate of spontaneous abortions as well as the risk of developing gestational diabetes is increased in PCOS. Therefore, PCOS is not only a reproductive problem, but a complex endocrine disease with important health implications. The role of glucose metabolism in PCOS, the health consequences and possible interventions are reviewed in this article.
Schröder
Annika K
AK
Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Schleswig-Hostein, Campus Lübeck, Lübeck, Deutschland.
Tauchert
Sascha
S
Ortmann
Olaf
O
Diedrich
Klaus
K
Weiss
Jürgen M
JM
D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology; D002839:Chromans / Q000627:therapeutic use; D018849:Controlled Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000209:etiology; D016640:Diabetes, Gestational / Q000209:etiology; D005260:Female; D005947:Glucose / Q000378:metabolism; D018149:Glucose Intolerance; D005951:Glucose Tolerance Test; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007231:Infant, Newborn; D007247:Infertility, Female / Q000209:etiology; D007333:Insulin Resistance; D008687:Metformin / Q000627:therapeutic use; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D010919:Placebos; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy; D017697:Premenopause; D015995:Prevalence; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D045162:Thiazolidinediones / Q000627:therapeutic use; D000077288:Troglitazone
D002839:Chromans; D007004:Hypoglycemic Agents; D010919:Placebos; D045162:Thiazolidinediones; D008687:Metformin; D000077288:Troglitazone; D005947:Glucose