[The role of platelet glycoprotein receptors and their ligands: fibrinogen and von Willebrand factor in arterial thrombosis].
The arterial platelet thrombus contribute to development of thrombotic complications of atherosclerosis: acute coronary syndrome, thrombotic strokes and exacerbations of peripheral arterial occlusive disease. Platelet adhesion and aggregation is mediated by interaction between platelet glycoprotein receptors GPI b/IX GPII b/III a and their ligands-adhesive proteins: von Willebrand factor (vWF) and/or fibrinogen. Pharmacological blockade of interaction between glycoproteins receptor and their ligands may offer an effective prevention of thrombotic complications.
Gosk-Bierska
Izabela
I
Katedra i Klinika Angiologii, Nadciśnienia Tetniczego i Diabetologii 50-326 Wrocław, ul. Poniatowskiego 2.
Adamiec
Rajmund
R
D003328:Coronary Thrombosis / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D010980:Platelet Membrane Glycoproteins / Q000502:physiology*; D014841:von Willebrand Factor / Q000378:metabolism*
D008024:Ligands; D010980:Platelet Membrane Glycoproteins; D014841:von Willebrand Factor; D005340:Fibrinogen