title: Responsive and recognitive hydrogels using star polymers.
abstract: Polymeric networks that have inherent capabilities to recognize different molecules and chemical changes in their environment are the next generation of materials that will aid in the diagnosis and treatment of diseases. We have prepared new networks based on star polymers that were designed to be responsive and recognitive. Using molecular imprinting with D-glucose and crosslinking with poly(ethylene glycol) dimethacrylate with an ethylene glycol chain of nominal molecular weight 600, we prepared star polymer networks, which exhibited over 300% more uptake for D-glucose compared to D-fructose. Using copolymerization with methacrylic acid, we prepared star polymer networks with pH-sensitivity, which showed a sharp transition in swelling around a pH of 4.5.
authors.affiliation: School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Ebru
authors.initials: E
authors.lastname: Oral
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Peppas
mesh_terms: D000179:Acrylates; D003432:Cross-Linking Reagents; D016503:Drug Delivery Systems; D005947:Glucose / Q000032:analysis; D020100:Hydrogels / Q000627:therapeutic use*; D006863:Hydrogen-Ion Concentration; D008689:Methacrylates; D008962:Models, Theoretical; D011092:Polyethylene Glycols; D011108:Polymers / Q000627:therapeutic use
chemical_list: D000179:Acrylates; D003432:Cross-Linking Reagents; D020100:Hydrogels; D008689:Methacrylates; D011108:Polymers; C421283:poly(ethylene glycol)-dimethacrylate; D011092:Polyethylene Glycols; D005947:Glucose