title: Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening.
authors.affiliation: Max-Planck-Institut für molekulare Physiologie, Abteilung Strukturelle Biologie, Dortmund, Germany.
authors.forename: Oliver
authors.initials: O
authors.lastname: Müller
authors.forename: Eleni
authors.initials: E
authors.lastname: Gourzoulidou
authors.forename: Mercedes
authors.initials: M
authors.lastname: Carpintero
authors.forename: Ioanna-Maria
authors.initials: IM
authors.lastname: Karaguni
authors.forename: Anette
authors.initials: A
authors.lastname: Langerak
authors.forename: Christian
authors.initials: C
authors.lastname: Herrmann
authors.forename: Tarik
authors.initials: T
authors.lastname: Möröy
authors.forename: Ludger
authors.initials: L
authors.lastname: Klein-Hitpass
authors.forename: Herbert
authors.initials: H
authors.lastname: Waldmann
mesh_terms: D000818:Animals; D017304:Annexin A5 / Q000032:analysis / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D017209:Apoptosis / Q000502:physiology; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D002460:Cell Line; D002461:Cell Line, Transformed; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D020650:Combinatorial Chemistry Techniques; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D004847:Epithelial Cells / Q000187:drug effects; D011905:Genes, ras / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D020128:Inhibitory Concentration 50; D008856:Microscopy, Fluorescence; D010641:Phenotype; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology; D013329:Structure-Activity Relationship; D013467:Sulindac / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D051153:Wnt Proteins; D029961:Zebrafish Proteins
chemical_list: D017304:Annexin A5; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D013467:Sulindac