title: Prophylactic ciprofloxacin drops after tympanostomy tube insertion.
abstract: OBJECTIVE
  To evaluate the effectiveness of prophylactic ciprofloxacin drops in decreasing the incidence of post-tympanostomy otorrhea, and the relation between middle ear content and post-tympanostomy otorrhea.
  
  
  METHODS
  One hundred and fifty patients aged 3-14 years underwent tympanostomy and tube insertion at the Prince Rashid Ben Al-Hasan Hospital, Al-Husn, Jordan during the interval between February 2000 to January 2003. The patients were randomized into 3 groups: group 1 (control group) received no antibiotic drops, group 2 received a single dose of ciprofloxacin drops intraoperatively and group 3 received an intraoperative dose followed by 5-day postoperative course.
  
  
  RESULTS
  Application of topical ciprofloxacin after tympanostomy tube insertion was associated with a significantly lower incidence of early post-tympanostomy otorrhea. The rate of otorrhea for the control group was 16.5% and the treatment groups were (group 1) 8.4%, (group 2) 8.2% and p=0.011. A single dose of antibiotics was effective when patient's middle ears were dry or had serous effusions. For those whose ears had mucoid or purulent content a 5-day course was indicated.
  
  
  CONCLUSIONS
  Topical administration of a single dose of ototopical ciprofloxacin after surgery is an effective treatment for the prevention of early post-tympanostomy otorrhea, and a prolonged course (5 days) may be indicated for those whose ears had purulent or thick mucoid contents, and the content of middle ear are important in predicating postoperative otorrhea.
authors.affiliation: Department of Otolaryngology, Prince Rashid Ben Al-Husn Hospital, Jordan. nawasreh1@hotmail.com
authors.forename: Omer
authors.initials: O
authors.lastname: Nawasreh
authors.forename: Ibrahim A
authors.initials: IA
authors.lastname: Al-Wedyan
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D019072:Antibiotic Prophylaxis; D002648:Child; D002675:Child, Preschool; D002939:Ciprofloxacin / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007430:Intraoperative Care; D007597:Jordan; D008297:Male; D008876:Middle Ear Ventilation / Q000009:adverse effects / Q000379:methods*; D010034:Otitis Media with Effusion / Q000175:diagnosis / Q000601:surgery*; D011182:Postoperative Care; D011183:Postoperative Complications / Q000517:prevention & control; D011336:Probability; D012016:Reference Values; D018570:Risk Assessment; D012996:Solutions; D016896:Treatment Outcome
chemical_list: D012996:Solutions; D002939:Ciprofloxacin