Suppressive activity of the fruit of Momordica charantia with exercise on blood glucose in type 2 diabetic mice.
The antidiabetic activity of Momordica charantia L. (Cucurbitaceae) with exercise was investigated in KK-Ay mice, an animal model with type 2 diabetes with hyperinsulinemia. The water extract of the fruit of Momordica charantia L. (MC) with exercise reduced the blood glucose of KK-Ay mice 5 weeks after oral administration (p<0.001), and also significantly lowered the plasma insulin of KK-Ay mice under similar conditions (p<0.01). The blood glucose of MC with exercise is lower than that of MC only or exercise only 5 weeks after the administration. MC with exercise decreased blood glucose in a glucose tolerance test. These results suggest that MC with exercise is useful for type 2 diabetic cure.
Miura
Toshihiro
T
Department of Clinical Nutrition, Suzuka University of Medical Science, 1000-1 Kishioka, Suzuka, Mie 510-0293, Japan. miura@suzuka-u.ac.jp
Itoh
Yasushi
Y
Iwamoto
Naoki
N
Kato
Motoshi
M
Ishida
Torao
T
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D001835:Body Weight; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy / Q000628:therapy*; D005638:Fruit / Q000737:chemistry; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D051379:Mice; D029777:Momordica charantia / Q000737:chemistry*; D010805:Physical Conditioning, Animal; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use; D013997:Time Factors
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D028321:Plant Preparations