[Heterochromia of the Iris after t-PA and Gas Injection of Sulfur Fluoride].
BACKGROUND
Are changes in iris colour and retinal pigment epithelium after t-PA and gas injection and subsequent vitreous haemorrhage caused by blood cells, or is this a toxic effect?


METHODS
A 81-year old female presented for vitrectomy with a persistent vitreous haemorrhage two months after t-PA and gas injection because of subretinal macular haemorrhage. Sonographic control revealed attached retina. The examination disclosed a new heterochromia of the iris with a change from blue to green-brown. A discrete anterior chamber flare and blood cells were found. Subsequent vitrectomy revealed a thick, rubber-like haemorrhage in the vitreous with suspect pigmentation. A change in retinal pigmentation was also evident.


CONCLUSIONS
The cause for the heterochromia and the change in pigmentation of the retinal pigment epithelium remained unclear. It may have been a consequence of the persistent bleeding with iron apposition on the iris. A toxic effect of t-PA has to be discussed which led to the alteration in pigmentation.
Hoffmann
Esther M
EM
Augenklinik und Poliklinik der Universitätsklinik Mainz. ehoffman@mail.uni-mainz.de
Schwenn
Oliver
O
D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D015863:Iridocyclitis / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D008266:Macula Lutea / Q000601:surgery*; D010857:Pigment Epithelium of Eye / Q000187:drug effects / Q000473:pathology; D011183:Postoperative Complications / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery; D012086:Reoperation; D012166:Retinal Hemorrhage / Q000601:surgery*; D013459:Sulfur Hexafluoride / Q000009:adverse effects* / Q000627:therapeutic use; D014821:Vitrectomy; D014823:Vitreous Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis / Q000601:surgery
D013459:Sulfur Hexafluoride