[Role of glycine in blood coagulation processes].
We studied hemocoagulation properties of the amino acid glycine in vitro and after intravenous administration in animals (rats). Addition of 10(-3) and 10(-4) M glycine to the plasma increases the aggregability of thrombocytes in vitro, while all other tested concentrations had virtually no effect on hemostatic parameters of the plasma. Intravenous administration of glycine increased functional activity of the enzyme fibrinolytic unit of the anticoagulation system. Dose dependence of this effect has been established. The causes of these changes and possible application of this compound for activation of fibrinolysis are discussed.
Liapina
L A
LA
Biology Faculty, Moscow State University, Vorob'evy Gory, Moscow, 119899 Russia.
Pastorova
V E
VE
Golubeva
M G
MG
Grigor'eva
M G
MG
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005342:Fibrinolysis / Q000187:drug effects; D005998:Glycine / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats
D005998:Glycine