title: A case of a large dermatofibrosarcoma protuberans successfully treated with radiofrequency ablation and transcatheter arterial embolization.
abstract: We present a large dermatofibrosarcoma protuberans on a 52 years-old woman's back that was successfully treated with transcatheter arterial embolization and radiofrequency ablation. The tumor developed on her back at the age of 14. Surgical treatment was not complete, and it relapsed at age 17 and again at age 24. The tumor enlarged to over 20x20x10 cm and flooded intermittently. The tumor cells with atypical nuclei were CD34 positive and proliferated in a storiform pattern. These findings were compatible with dermatofibrosarcoma protuberans. She was treated with blood transfusion for severe anemia. Two large feeding arteries were embolized, and the bottom of the tumor was treated with radiofrequency ablation. The tumor reduced in volume by more than 50%. It was then surgically removed and reconstructed with a free mesh skin graft. The combination pretreatment enabled radical resections of a large DFSP without severe complications.
authors.affiliation: Department of Dermatology, Mie University, Faculty of Medicine, Tsu, Japan.
authors.forename: Yasutomo
authors.initials: Y
authors.lastname: Imai
authors.forename: Koji
authors.initials: K
authors.lastname: Habe
authors.forename: Mika
authors.initials: M
authors.lastname: Imada
authors.forename: Arata
authors.initials: A
authors.lastname: Hakamada
authors.forename: Ken-Ich
authors.initials: KI
authors.lastname: Isoda
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Yamanishi
authors.forename: Atsumasa
authors.initials: A
authors.lastname: Uchida
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Mizutani
mesh_terms: D001707:Biopsy, Needle; D017115:Catheter Ablation / Q000379:methods*; D003131:Combined Modality Therapy / Q000379:methods; D018223:Dermatofibrosarcoma / Q000473:pathology* / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D018570:Risk Assessment; D012878:Skin Neoplasms / Q000473:pathology* / Q000628:therapy*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome