title: Fluorinated dihydroquinolines as potent n-NOS inhibitors.
abstract: Fluorinated dihydroquinolines showed reduced basicity of the amidine function. Their syntheses and potencies as neuronal nitric oxide synthase (n-NOS) inhibitors are reported.
authors.affiliation: Medicinal Chemistry, Corporate Research, Research Center Europe, Schering AG, D-13342-Berlin, Germany. stefan.jaroch@schering.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Jaroch
authors.forename: Hartmut
authors.initials: H
authors.lastname: Rehwinkel
authors.forename: Peter
authors.initials: P
authors.lastname: Hölscher
authors.forename: Detlev
authors.initials: D
authors.lastname: Sülzle
authors.forename: Gerardine
authors.initials: G
authors.lastname: Burton
authors.forename: Margrit
authors.initials: M
authors.lastname: Hillmann
authors.forename: Fiona M
authors.initials: FM
authors.lastname: McDonald
authors.forename: Heribert
authors.initials: H
authors.lastname: Miklautz
mesh_terms: D000578:Amidines / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005461:Fluorine / Q000737:chemistry*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052248:Nitric Oxide Synthase Type I; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000578:Amidines; D004791:Enzyme Inhibitors; D011804:Quinolines; D005461:Fluorine; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I