[Clinical analysis of orbital histocytosis X].
OBJECTIVE
To study the clinical and imaging features together with diagnosis and management of orbital histocytosis X.


METHODS
In a retrospective study from 1973 to 1999, 47 cases of histocytosis X were reviewed related with clinical materials, including eosinophilic granuloma 17 cases and Hand-Schuller- Christian disease 30 cases.


RESULTS
Most occur in children and teenagers, mainly in male. Characteristic clinical features, roentgenography, ultrasonography, CT, MRI provide the most diagnostic assistance.


CONCLUSIONS
Solitary unifocal eosinophilic granuloma mainly involves teenagers. Hand-Schuller-Christian disease usually take places between birth and 5 years of age, which is characterized by multifocal variant of eosinophilic granuloma, especially the classic triad. Characteristic images contribute to the diagnosis. Multiple management is needed, including surgery, chemotherapy and radiotherapy. The prognosis varies with the three types.
Zhou
Xiao-dong
XD
Tianjin Orbit Institute, Department of Ophthalmology, The Second Affiliated Hospital, Tianjin Medical University, Tianjin 300211, China. zxdeye@sina.com
Song
Guo-xiang
GX
He
Yan-jin
YJ
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009916:Orbital Diseases / Q000175:diagnosis*; D011379:Prognosis; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed