[Anti-amnestic activities of 3-hydroxy-3-pyrroline-2-one derivatives].
The antiamnesic properties of a series of new 3-hydroxy-3-pyrrolin-2-on derivatives structurally analogous to pyrrolidinone nootropes and GABA were studied on a model of amnesia of the passive avoidance conditioned reflex. The screening revealed compounds whose antiamnesic action is comparable with that of piracetam.
Shuklina
N S
NS
Pharmacology Department, Perm State Pharmaceutical Academy, ul. Lenina 48, Perm, 614000 Russia.
Kolla
V E
VE
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D018697:Nootropic Agents / Q000737:chemistry / Q000494:pharmacology*; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D018697:Nootropic Agents; D011758:Pyrroles