10-year follow-up of women who elected quinacrine sterilization (QS) in Wonosobo, Central Java, Indonesia.
To evaluate the safety and efficacy of quinacrine sterilization (QS) in Indonesia.



During the period, August 1992 to October 1993, 200 women who had requested surgical sterilization volunteered for QS at the Wonosobo Regency Hospital, Central Java Province, Indonesia. The protocol called for transcervical insertion of 252 mg of quinacrine in the form of 7 cylindrical pellets and 55.5 mg of ibuprofen with a CuT-IUD (Kimia Farma) inserter during the proliferative phase of the menstrual cycle. A second procedure was done 4 weeks later. The technique used is essentially the same as inserting a CuT-IUD. Follow-up was scheduled at 6, 12, 24 and 48 months after the last insertion. In March 2003 additional monitoring was completed.



The 10-year cumulative pregnancy rate was 4.3 per 100 women with a follow-up rate of 93%. No pregnancies had occurred among these women since the 4-year follow-up. No long-term side effects or complications were reported.



After 10 years of use, QS was found to be safe and reasonably effective.
Suhadi
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Department of Obstetrics and Gynecology, Wonosobo General Hospital, Wonosobo, Central Java, Indonesia. agungspogyahoo.com
Anwar
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Soejoenoes
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D000328:Adult; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage; D004343:Drug Implants; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage; D007214:Indonesia; D011247:Pregnancy; D011446:Prospective Studies; D011796:Quinacrine / Q000008:administration & dosage* / Q000009:adverse effects; D012102:Reproductive Control Agents / Q000008:administration & dosage* / Q000009:adverse effects; D013246:Sterilization, Tubal; D013997:Time Factors
D016861:Cyclooxygenase Inhibitors; D004343:Drug Implants; D012102:Reproductive Control Agents; D011796:Quinacrine; D007052:Ibuprofen