title: Membrane cholesterol and the regulation of signal transduction.
abstract: The plasma membrane of mammalian cells consists of microdomains differing in lipid and protein composition. Two distinct classes of cholesterol/sphingolipid microdomain (caveolae and lipid rafts) are assembly points for transmembrane signalling complexes. Recent evidence suggests that transient changes in cholesterol content may be important in regulating signal transduction.
authors.affiliation: Cardiovascular Research Institute and Department of Physiology, University of California, San Francisco, CA 94143, USA. cfield@itsa.ucsf.edu
authors.forename: C J
authors.initials: CJ
authors.lastname: Fielding
authors.forename: P E
authors.initials: PE
authors.lastname: Fielding
mesh_terms: D000818:Animals; D021941:Caveolae / Q000737:chemistry / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism*; D006706:Homeostasis; D021962:Membrane Microdomains / Q000737:chemistry* / Q000378:metabolism* / Q000821:virology; D015398:Signal Transduction
chemical_list: D002784:Cholesterol