A malignant peripheral nerve-sheath tumour responding to chemotherapy.
A malignant peripheral nerve-sheath tumour developed in the right S1 nerve root in a man aged 30 causing back pain and sciatica. CT and MRI revealed a destructive tumour of the sacrum invading the retroperitoneal space. The tumour was not resectable with an adequate margin. Chemotherapy, consisting of high-dose ifosfamide followed by a combination of vincristine, doxorubicin and cyclophosphamide, was given with success. Malignant peripheral nerve-sheath tumours are thought to respond weakly to chemotherapy, but the response in our patient was complete.
Masui
F
F
Department of Orthopaedic Surgery, Jikei University School of Medicine, National Cancer Centre Hospital, Tokyo, Japan.
Yokoyama
R
R
Soshi
S
S
Beppu
Y
Y
Asanuma
K
K
Fujii
K
K
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001416:Back Pain / Q000209:etiology; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008297:Male; D018317:Nerve Sheath Neoplasms / Q000150:complications / Q000188:drug therapy*; D012585:Sciatica / Q000209:etiology; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D007069:Ifosfamide