title: Functional neurochemistry of Alzheimer's disease.
abstract: A review of neurochemical research on classical neurotransmitters, i.e. acetylcholine, serotonin, noradrenaline, dopamine, glutamate, and GABA in Alzheimer's disease is presented. Findings are linked to the information processing system of the human brain to establish a more functional neurochemistry. On this basis, different pharmacotherapeutic strategies are discussed. Our conclusion is that current symptomatic therapy of Alzheimer's disease is insufficient. Besides therapy with acetylcholinesterase inhibitors, comedication to act on imbalances between serotonin and noradrenaline on the one site, and dopamine, glutamate and GABA on the other site should should be considered.
authors.affiliation: Psychiatric, Psychotherapeutic and Neurological State Hospital, Lohr am Main, Germany. Wieland.Gsell@bezirkskrankenhaus-lohr.de
authors.forename: Wieland
authors.initials: W
authors.lastname: Gsell
authors.forename: Gerd
authors.initials: G
authors.lastname: Jungkunz
authors.forename: Peter
authors.initials: P
authors.lastname: Riederer
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006801:Humans; D018377:Neurotransmitter Agents / Q000502:physiology*; D017981:Receptors, Neurotransmitter / Q000378:metabolism / Q000502:physiology
chemical_list: D002800:Cholinesterase Inhibitors; D018377:Neurotransmitter Agents; D017981:Receptors, Neurotransmitter