title: Sequence analysis of both genome segments of two very virulent infectious bursal disease virus field isolates with distinct pathogenicity.
abstract: The deduced amino acid sequences of segment A and B of two very virulent Infectious bursal disease virus (vvIBDV) isolates, UPM94/273 and UPM97/61 were compared with 25 other IBDV strains. Twenty amino acid residues (8 in VP1, 5 in VP2, 2 in VP3, 4 in VP4, 1 in VP5) that were common to vvIBDV strains were detected. However, UPM94/273 is an exceptional vvIBDV with usual amino acid substitutions. The differences in the divergence of segment A and B indicated that the vvIBDV strains may have been derived from genetic reassortment of a single ancestral virus or both segments have different ability to undergo genetic variation due to their different functional constraints.
authors.affiliation: Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Malaysia.
authors.forename: L L
authors.initials: LL
authors.lastname: Kong
authors.forename: A R
authors.initials: AR
authors.lastname: Omar
authors.forename: M
authors.initials: M
authors.lastname: Hair-Bejo
authors.forename: I
authors.initials: I
authors.lastname: Aini
authors.forename: H F
authors.initials: HF
authors.lastname: Seow
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002645:Chickens / Q000821:virology; D014644:Genetic Variation / Q000235:genetics; D016679:Genome, Viral; D007243:Infectious bursal disease virus / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity*; D008969:Molecular Sequence Data; D020125:Mutation, Missense / Q000235:genetics; D016366:Open Reading Frames / Q000235:genetics; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D015678:Viral Structural Proteins / Q000737:chemistry / Q000235:genetics; D014774:Virulence / Q000235:genetics
chemical_list: D015678:Viral Structural Proteins