Low androgenization index in elderly women and elderly men with Alzheimer's disease.
The authors investigated whether testosterone levels and testosterone availability differ between older lean subjects with and without Alzheimer's disease (AD). Sex hormone binding globulin (SHBG) and estradiol levels were higher, whereas the free androgenization index (FAI) was lower, in lean subjects with AD than in lean subjects without AD. Factors involved in the increase of SHBG secretion could have an important role in the lower testosterone availability of subjects with AD.
Paoletti
A M
AM
Department of Obstetrics and Gynecology, University of Cagliari, Italy.
Congia
S
S
Lello
S
S
Tedde
D
D
Orrù
M
M
Pistis
M
M
Pilloni
M
M
Zedda
P
P
Loddo
A
A
Melis
G B
GB
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood*; D015992:Body Mass Index; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013739:Testosterone / Q000097:blood* / Q000172:deficiency; D013851:Thinness / Q000097:blood
D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D006854:Hydrocortisone