Genetic determinants of obesity-related lipid traits.
In our ongoing effort to identify genes influencing the biological pathways that underlie the metabolic disturbances associated with obesity, we performed genome-wide scanning in 2,209 individuals distributed over 507 Caucasian families to localize quantitative trait loci (QTLs), which affect variation of plasma lipids. Pedigree-based analysis using a quantitative trait variance component linkage method that localized a QTL on chromosome 7q35-q36, which linked to variation in levels of plasma triglyceride [TG, logarithm of odds (LOD) score = 3.7] and was suggestive of linkage to LDL-cholesterol (LDL-C, LOD = 2.2). Covariates of the TG linkage included waist circumference, fasting insulin, and insulin:glucose, but not body mass index or hip circumference. Plasma HDL-cholesterol (HDL-C) levels were suggestively linked to a second QTL on chromosome 12p12.3 (LOD = 2.6). Five other QTLs with lower LOD scores were identified for plasma levels of LDL-C, HDL-C, and total cholesterol. These newly identified loci likely harbor genetic elements that influence traits underlying lipid adversities associated with obesity.
Sonnenberg
Gabriele E
GE
Division of Endocrinology, Metabolism and Clinical Nutrition, Department of Medicine and Human Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, WI, USA. gsonnen@mcw.edu
Krakower
Glenn R
GR
Martin
Lisa J
LJ
Olivier
Michael
M
Kwitek
Anne E
AE
Comuzzie
Anthony G
AG
Blangero
John
J
Kissebah
Ahmed H
AH
D001786:Blood Glucose; D001837:Body Weights and Measures; D002784:Cholesterol / Q000097:blood; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D005192:Family Health; D005260:Female; D015894:Genome, Human; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000235:genetics*; D008297:Male; D009765:Obesity / Q000235:genetics*; D040641:Quantitative Trait Loci; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol