title: The regulation of bone development as a biological system.
abstract: A large number of molecular, cellular, and epidemiologic factors have been implicated in the regulation of bone development. A major unsolved problem is how to integrate these disparate findings into a concept that explains the development of bone as an organ. Often, events at the organ level are simply presented as the cumulative effect of all factors that individually are known to influence bone development. In such a cumulative model it must be assumed that each bone cell carries the construction plan of the entire skeletal anatomy in its genes. This scenario is implausible, because it would require an astronomical amount of positional information. We therefore propose a functional model of bone development, which is based on Frost's mechanostat theory. In this model, the genome only provides positional information for the basic outline of the skeleton as a cartilaginous template. Thereafter, bone cell action is coordinated by the mechanical requirements of the bone.
authors.affiliation: Kinderklinik der Universität Köln, 50924 Köln, Deutschland. Eckhard.Schoenau@medizin.uni-koeln.de
authors.forename: E
authors.initials: E
authors.lastname: Schoenau
authors.forename: O
authors.initials: O
authors.lastname: Fricke
authors.forename: F
authors.initials: F
authors.lastname: Rauch
mesh_terms: D000818:Animals; D001846:Bone Development; D001842:Bone and Bones / Q000166:cytology; D002356:Cartilage / Q000254:growth & development; D006801:Humans; D008962:Models, Theoretical