title: [Transformation of glycyrrhizinic acid. XV. Synthesis of triterpene saponins with monosaccharide residues, attached through complex ester bonds].
abstract: Triterpene saponins, glycoside analogues of glycyrrhizic acid with a modified carbohydrate chain containing monosaccharide residues attached through ester bonds, were synthesized. To this end, peracetylated glycyrrhizic acid or its 30-methyl ester were glycosylated by 2,3,4,6-tetra-O-acetyl-alpha-D-gluco-or-alpha-D-galactopyranosyl bromide in dichloroethane in the presence of Ag2CO3. Glycerrhetinic acid saponin with D-Galp residues exhibited a higher antiulcer activity than glycyrrhizic acid in rats at a dose of 25 mg/kg. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2003, vol. 29, no. 6; see also http://www.maik.ru.
authors.affiliation: Institute of Organic Chemistry, Ufa Research Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054 Russia.
authors.forename: R M
authors.initials: RM
authors.lastname: Kondratenko
authors.forename: L A
authors.initials: LA
authors.lastname: Baltina
authors.forename: S R
authors.initials: SR
authors.lastname: Mustafina
authors.forename: E V
authors.initials: EV
authors.lastname: Vasil'eva
authors.forename: A F
authors.initials: AF
authors.lastname: Ismagilova
authors.forename: N G
authors.initials: NG
authors.lastname: Vasil'eva
authors.forename: G A
authors.initials: GA
authors.lastname: Tolstikov
mesh_terms: D000818:Animals; D004952:Esters / Q000737:chemistry*; D019695:Glycyrrhizic Acid / Q000737:chemistry*; D009005:Monosaccharides / Q000737:chemistry*; D051381:Rats; D013055:Spectrophotometry, Infrared
chemical_list: D004952:Esters; D009005:Monosaccharides; D019695:Glycyrrhizic Acid