The molecular basis of infectious diseases: pathogenicity islands and other mobile genetic elements. A review.
Bacterial genomes generally consist of stable regions termed core genome, and variable regions that form the so-called flexible gene pool. The flexible part is composed of bacteriophages, plasmids, transposons as well as unstable large regions that have been termed genomic islands. Genomic islands encoding virulence factors of pathogenic bacteria have been designated "pathogenicity islands". Pathogenicity islands were first discovered in uropathogenic Escherichia coli and presently more than 30 bacterial species carrying pathogenicity islands have been described. This review summarises the current knowledge on bacterial genomic islands and their general features, and discusses their putative role in the evolution of microbes in the light of genomics of pathogenic bacteria.
Hacker
J
J
Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, D-97070 Würzburg, Deutschland. j.hacker@mail.uni-wuerzburg.de
Blum-Oehler
Gabriele
G
Hochhut
Bianca
B
Dobrindt
U
U
D000818:Animals; D001419:Bacteria / Q000235:genetics* / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000209:etiology* / Q000382:microbiology; D005075:Biological Evolution; D004926:Escherichia coli / Q000235:genetics / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000209:etiology; D016680:Genome, Bacterial; D042822:Genomic Instability; D044404:Genomic Islands; D006801:Humans; D014552:Urinary Tract Infections / Q000209:etiology; D014774:Virulence / Q000235:genetics