Anxiolytic-like effects of rose oil inhalation on the elevated plus-maze test in rats.
The effect of rose oil inhalation (1.0%, 2.5%, and 5.0% w/w) on the elevated plus-maze (EPM) test was investigated in adult male rats and compared with the effect of diazepam (DZP) (1.0 and 2.0 mg/kg) administered intraperitoneally 30 min before testing. Exposure to rose oil produced an anxiolytic-like effect similar to DZP (anxiolytic reference drug). Thus, at some concentrations, rose oil significantly increased the number of visits to and time spent in the open arms of the EPM. Anxiolytic-like properties of rose oil were observed using the EPM, being consistent with other behavioral and clinical studies.
de Almeida
Reinaldo Nóbrega
RN
Department of Physiology and Pathology/LTF, Universidade Federal da Paraíba-Caixa, P.O. Box 5009, PB 58051-970, João Pessoa, Brazil. reinaldoan@uol.com.br
Motta
Simone Cristina
SC
de Brito Faturi
Claudia
C
Catallani
Bruna
B
Leite
José Roberto
JR
D000280:Administration, Inhalation; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001007:Anxiety / Q000523:psychology*; D003975:Diazepam / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D027826:Rosa / Q000737:chemistry*
D014151:Anti-Anxiety Agents; D010938:Plant Oils; D003975:Diazepam