[Evaluation of the systolic and diastolic function of the left ventricle in patients with diabetes mellitus and microalbuminuria].
The objective of this study is to reveal the deterioration of the systolic and diastolic function of the left ventricle (LV) in patients with diabetes mellitus (DM), in correlation with type of DM, the edge and the complications of DM and the associated diagnosis.


METHODS
The study included 43 patients with DM (29 patients with DM type 1 or 2 insulinodependent--DMID and 14 patients with DM type 2 nonisulinodependent--DMNID). The age of patients was between 21 years and 57 years, with a duration of DM between 1 year and 22 years. The ecocardiographic evaluation have determined 38 parameters (B mod, M mod, CWD, PWD, colour Doppler). From these parameters, 12 was used for the measurement of the systolic function of the LV and 18 was used for the determination of the diastolic function of the left ventricle. The clinical and biological exam have performed: glycaemia, proteinuria, dyslipidemic syndrome, complications of DM and ischaemic heart disease (ECG).


RESULTS
The ejection fraction (EF) of the LV was ?60% in 23 patients, between 50% and 60% in 17 patients and between 40% and 50% in 3 patients. The values of MSER (mean systolic ejection rate) was between 221 ml/s şi 515 ml/s and the values of MVCF (mean velocity of circumferential shortening) was between 0.9 circ/s şi 1, 8 circ/s. The ratio of the E and A waves at the mitral valve was > 1 in 22 patients and < 1 in 21 patients. The LV isovolumic relaxation time (IVRT) was < 70 ms in 13 patients, > 100 ms in 14 patients and had normal values in 16 patients. The E wave deceleration time (EDT) was < 150 ms in 24 patients and had normal values in 19 patients. There is no connection between the systolic/diastolic function and the other determined parameters.


CONCLUSIONS
The alteration of the LV systolic function was present in 20 patients from 43 patients. The LV diastolic dysfunction through relaxation troubles was present in 14 patients and the LV diastolic dysfunction through compliance trouble was present in 13 patients. A number of 16 patients had preserved (for the moment) a normal LV diastolic function. The number of patients with these two types of LV diastolic dysfunction was equal in our study. Other studies had found a predominance of LV diastolic dysfunction through compliance troubles in DM.
Artenie
Anca
A
Clinica a IV-a Medicală, Spitalul Clinic C.I. Parhon Iaşi.
Ungureanu
Didona
D
Artenie
R
R
Botnariu
Gina
G
Anisie
Ecaterina
E
D000328:Adult; D000419:Albuminuria / Q000209:etiology / Q000503:physiopathology*; D000465:Algorithms; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000503:physiopathology*; D003971:Diastole / Q000502:physiology; D004562:Electrocardiography; D006801:Humans; D008875:Middle Aged; D013599:Systole / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000503:physiopathology*