title: In vitro interactions of licensed and novel antifungal drugs against Fusarium spp.
abstract: We have studied the in vitro interactions of amphotericin B (AMB) with terbinafine (TBF), itraconazole, voriconazole (VCZ), albaconazole, and ravuconazole (RVZ), as well as TBF combined with the same azoles, against 11 isolates of Fusarium spp. using the fractional inhibitory concentration index. The highest percentage of synergistic interactions was observed for the combinations AMB-RVZ, TBF-VCZ, and TBF-RCZ.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: Montserrat
authors.initials: M
authors.lastname: Ortoneda
authors.forename: Javier
authors.initials: J
authors.lastname: Capilla
authors.forename: F
authors.initials: F
authors.lastname: Javier Pastor
authors.forename: Isabel
authors.initials: I
authors.lastname: Pujol
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D004347:Drug Interactions; D025141:Drug Resistance, Fungal; D005670:Fusarium / Q000145:classification / Q000187:drug effects*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D011799:Quinazolines / Q000494:pharmacology; D012680:Sensitivity and Specificity; D000077291:Terbinafine; D013844:Thiazoles / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D011743:Pyrimidines; D011799:Quinazolines; D013844:Thiazoles; D014230:Triazoles; D017964:Itraconazole; D000666:Amphotericin B; C104066:ER 30346; D000077291:Terbinafine; D065819:Voriconazole; C112424:albaconazole