Gonadotropin releasing hormone antagonists and cryopreservation outcome: a review.
METHODS
The outcome of freeze-thaw cycles with pronuclear stage oocytes or embryos, derived from collecting cycles stimulated with gonadotropin-releasing hormone (GnRH)-antagonists' protocols, was reviewed.


CONCLUSIONS
The viability of cryopreserved pronuclear stage oocytes and embryos, the quality of transferred embryos and the pregnancy rates of the freeze-thaw cycles seem to be satisfactory regardless of the type and dose of GnRH-antagonist.
Nikolettos
N
N
Laboratory of Reproductive Physiology-IVF, Faculty of Medicine, Democritus University of Thrace, 68100, Dragana, Alexandroupolis, Greece. nnikolettos@hotmail.com
Asimakopoulos
B
B
Simopoulou
M
M
Al-Hasani
S
S
Diedrich
K
K
D015925:Cryopreservation; D010064:Embryo Implantation / Q000187:drug effects; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000494:pharmacology; D006727:Hormone Antagonists / Q000494:pharmacology*; D006801:Humans; D008186:Luteolytic Agents / Q000494:pharmacology; D009865:Oocytes / Q000187:drug effects / Q000502:physiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D011966:Receptors, LHRH / Q000378:metabolism; D017329:Triptorelin Pamoate / Q000494:pharmacology
D006727:Hormone Antagonists; D008186:Luteolytic Agents; D011966:Receptors, LHRH; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; C061018:ganirelix; C062876:cetrorelix