Synthesis of an S-linked glycopeptide analog derived from human Tamm-Horsfall glycoprotein.
Direct base catalyzed S-glycosylation of a cysteine and a homocysteine containing peptide with O-acetyl protected bromides in DMF-water solution furnished two glycopeptide fragments. The two glycopeptide fragments were linked to the target glycopeptide with two S-glycosyl residues mimicking a part of Tamm-Horsfall glycoprotein.
Zhu
Xiangming
X
Fachbereich Chemie, Universität Konstanz, Fach M 725, D-78457 Konstanz, Germany.
Haag
Tobias
T
Schmidt
Richard R
RR
D003545:Cysteine / Q000737:chemistry; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D009088:Mucoproteins / Q000737:chemistry; D058949:Uromodulin
D006020:Glycopeptides; D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin; D003545:Cysteine