title: Pruritus in a patient with advanced cancer successfully treated with continuous infusion of granisetron.
abstract: We present a case of a patient with advanced cancer affected by severe pruritus not related with cholestasis and/or opioid treatment successfully treated with subcutaneous continuous infusion of granisetron (3 mg/24 h diluted in normal saline via a disposable elastomeric infusion device). Confirmatory studies with a control group are warranted to confirm these preliminary results.
authors.affiliation: Supportive Care and Rehabilitation Unit, Medical Oncology Department, University of L'Aquila, L'Aquila, Italy. porzio1@interfree.it
authors.forename: Giampiero
authors.initials: G
authors.lastname: Porzio
authors.forename: Federica
authors.initials: F
authors.lastname: Aielli
authors.forename: Filomena
authors.initials: F
authors.lastname: Narducci
authors.forename: Katia
authors.initials: K
authors.lastname: Cannita
authors.forename: Domenico
authors.initials: D
authors.lastname: Piccolo
authors.forename: Paolo
authors.initials: P
authors.lastname: Marchetti
mesh_terms: D000368:Aged; D005260:Female; D017829:Granisetron / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D009369:Neoplasms / Q000150:complications* / Q000503:physiopathology; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D017829:Granisetron; D012702:Serotonin Antagonists