title: Studies on some glitazones having pyridine as the linker unit.
abstract: Molecular modeling on various well-known glitazones carrying a pyridine ring instead of benzene ring as the middle linker unit showed conformational rigidity as compared to their parent molecules. Blocking the lone pair of electrons on the pyridine N, made them flexible once again. A few representatives of these analogues were synthesized and their efficacy as PPARgamma agonists evaluated.
authors.affiliation: Department of Pharmaceutical Technology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar-160 062, India. umaram54@yahoo.com
authors.forename: Uma
authors.initials: U
authors.lastname: Ramachandran
authors.forename: Alka
authors.initials: A
authors.lastname: Mital
authors.forename: Prasad V
authors.initials: PV
authors.lastname: Bharatam
authors.forename: Smriti
authors.initials: S
authors.lastname: Khanna
authors.forename: Poduri Rama
authors.initials: PR
authors.lastname: Rao
authors.forename: Krishnamoorthy
authors.initials: K
authors.lastname: Srinivasan
authors.forename: Rakesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Harmander Pal Singh
authors.initials: HP
authors.lastname: Chawla
authors.forename: Chaman Lal
authors.initials: CL
authors.lastname: Kaul
authors.forename: Suryaprakash
authors.initials: S
authors.lastname: Raichur
authors.forename: Ranjan
authors.initials: R
authors.lastname: Chakrabarti
mesh_terms: D002460:Cell Line; D006358:Hot Temperature; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists; D045162:Thiazolidinediones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014157:Transcription Factors / Q000819:agonists
chemical_list: D011725:Pyridines; D018160:Receptors, Cytoplasmic and Nuclear; D045162:Thiazolidinediones; D014157:Transcription Factors; C023666:pyridine