Dietary flavonoids and iodine metabolism.
Flavonoids have inhibiting effects on the proliferation of cancer cells, including thyroidal ones. In the treatment of thyroid cancer the uptake of iodide is essential. Flavonoids are known to interfere with iodide organification in vitro, and to cause goiter. The influence of flavonoids on iodine metabolism was studied in a human thyroid cancer cell line (FTC-133) transfected with the human sodium/iodide transporter (NIS). All flavonoids inhibited growth, and iodide uptake was decreased in most cells. NIS mRNA expression was affected during the early hours after treatment, indicating that these flavonoids can act on NIS. Pendrin mRNA expression did not change after treatment. Only myricetin increased iodide uptake. Apeginin, luteolin, kaempferol and F21388 increased the efflux of iodide, leading to a decreased retention of iodide. Instead myricetin increased the retention of iodide; this could be of use in the radioiodide treatment of thyroid cancer.
Schröder-van der Elst
Janny P
JP
Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands. J.P.van.der.Elst@LUMC.nl
Smit
Jan W A
JW
Romijn
Hans A
HA
van der Heide
Daan
D
D002455:Cell Division / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007455:Iodine / Q000378:metabolism* / Q000493:pharmacokinetics; D012333:RNA, Messenger / Q000187:drug effects; D027981:Symporters / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D013961:Thyroid Gland / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D013997:Time Factors; D014407:Tumor Cells, Cultured; D000099209:Sodium-Iodide Symporters
D005419:Flavonoids; D007455:Iodine; D012333:RNA, Messenger; D027981:Symporters; D000099209:Sodium-Iodide Symporters