Deep brain stimulation for parkinson's disease: correlation between intraoperative subthalamic nucleus neurophysiology and most effective contacts.
Though intraoperative neurophysiology is essential to precisely define the definitive target, little is known regarding its predictive value in defining the most effective contact for chronic deep brain stimulation. In this retrospective study, we reviewed the correlation between intraoperative neurophysiology and contacts selected for chronic stimulation. Twenty consecutive patients implanted for subthalamic nucleus (STN) stimulation were reviewed. There was no significant correlation between the electrophysiologically defined STN and the most effective contact for chronic stimulation at 3 months or at 6 months. Furthermore, there was a discrepancy between the most effective contact for rigidity versus akinesia or tremor at 3 months. Interestingly, at 3 months, the same electrode contact was maximally efficient for rigidity, akinesia and tremor in only 13 of the 39 cases. This lack of correlation did not affect the global improvement.
Cintas
P
P
Department of Neurosciences, CHU Toulouse, University Paul Sabatier, Toulouse, France. cintas.p@chu-toulouse.fr
Simonetta-Moreau
M
M
Ory
F
F
Brefel-Courbon
C
C
Fabre
N
N
Chaynes
P
P
Sabatier
J
J
Sol
J C
JC
Rascol
O
O
Berry
I
I
Lazorthes
Y
Y
D000328:Adult; D000368:Aged; D004599:Electric Stimulation Therapy / Q000379:methods*; D004567:Electrodes, Implanted; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010300:Parkinson Disease / Q000503:physiopathology / Q000601:surgery* / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000601:surgery*; D016896:Treatment Outcome