Simulation of some short-term control mechanisms in cardiovascular physiology.
The equivalent electronic circuit, developed to simulate cardiovascular physiology, is upgraded to incorporate negative feedback loops. In this way homeostasis of the arterial pressure is simulated in exercise, in haemorrhage, in the insufficiency of the aortic valve, and in hypervolemia. The results show that homeostasis supports the cardiovascular system by modulating Starling mechanism(s) in exercise, haemorrhage and hypervolemia. In aortic insufficiency it seems that only Starling mechanism(s) can maintain cardiac output and arterial pressure.
Podnar
T
T
Faculty of Medicine, University Hospital of Pediatrics, University of Ljubljana, 1104 Ljubljana, Slovenia.
Runovc
F
F
Milisav
Irina
I
Kordas
M
M
D001022:Aortic Valve Insufficiency / Q000503:physiopathology; D001810:Blood Volume / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D003198:Computer Simulation; D004553:Electric Conductivity; D015444:Exercise / Q000502:physiology; D006470:Hemorrhage / Q000503:physiopathology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D008955:Models, Cardiovascular