The genome sequence of Mycoplasma mycoides subsp. mycoides SC type strain PG1T, the causative agent of contagious bovine pleuropneumonia (CBPP).
Mycoplasma mycoides subsp. mycoidesSC (MmymySC)is the etiological agent of contagious bovine pleuropneumonia (CBPP), a highly contagious respiratory disease in cattle. The genome of Mmymy SC type strain PG1(T) has been sequenced to map all the genes and to facilitate further studies regarding the cell function of the organism and CBPP. The genome is characterized by a single circular chromosome of 1211703 bp with the lowest G+C content (24 mole%)and the highest density of insertion sequences (13% of the genome size)of all sequenced bacterial genomes. The genome contains 985 putative genes, of which 72 are part of insertion sequences and encode transposases. Anomalies in the GC-skew pattern and the presence of large repetitive sequences indicate a high genomic plasticity. A variety of potential virulence factors was identified, including genes encoding putative variable surface proteins and enzymes and transport proteins responsible for the production of hydrogen peroxide and the capsule, which is believed to have toxic effects on the animal.
Westberg
Joakim
J
Department of Biotechnology, Royal Institute of Technology (KTH), SE-106 91 Stockholm, Sweden.
Persson
Anja
A
Holmberg
Anders
A
Goesmann
Alexander
A
Lundeberg
Joakim
J
Johansson
Karl-Erik
KE
Pettersson
Bertil
B
Uhlén
Mathias
M
D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics; D001483:Base Sequence / Q000235:genetics; D001692:Biological Transport / Q000235:genetics; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology*; D004261:DNA Replication / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics*; D005815:Genetic Code / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D016680:Genome, Bacterial; D008565:Membrane Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D009175:Mycoplasma Infections / Q000150:complications; D009176:Mycoplasma mycoides / Q000235:genetics*; D011002:Pleuropneumonia, Contagious / Q000382:microbiology*; D014176:Protein Biosynthesis / Q000235:genetics; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D013045:Species Specificity; D014158:Transcription, Genetic; D037521:Virulence Factors / Q000235:genetics
D000942:Antigens, Bacterial; D004269:DNA, Bacterial; D008565:Membrane Proteins; D037521:Virulence Factors