The role of MAP kinases in trauma and ischemia-reperfusion.
Mitogen-activated protein kinases (MAPKs) have been the focus of a number of studies, as these compounds are involved in a number of important inflammatory cell signaling mechanisms. Recent studies have further elucidated the role of MAPKs in the inflammatory response, as a result of trauma and/or ischemia-reperfusion (I/R) injury. There are three major classes of MAPKs that may be involved in the inflammatory response: extracellular signal-regulated kinases (ERKs), stress-activated protein kinases (SAPKs)/c-Jun NH(2)-terminal kinases (JNKs), and p38 MAPKs (p38). This is clinically relevant, because these pathways may be a possible target for anti-inflammatory drug intervention. This review studies the role of MAPKs in trauma and/or I/R.
Lai
Edwin W
EW
Michigan State University/Kalamazoo Center for Medical Studies, Kalamazoo, Michigan, USA.
Toledo-Pereyra
Luis H
LH
Walsh
Jon
J
Lopez-Neblina
F
F
Anaya-Prado
R
R
D000818:Animals; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D015427:Reperfusion Injury / Q000378:metabolism*; D014947:Wounds and Injuries / Q000378:metabolism*
D020928:Mitogen-Activated Protein Kinases