title: Migration of polyethylene debris along well-fixed cemented implants.
abstract: Implants, consisting of smooth Inox cylinders, were cemented into the lower femur and upper tibia of nine sheep to study the distal migration of polyethylene particles. Some implants had a titanium-bead porous coat at the proximal end. These were of three types: In the first type, the porous coat was covered with hydroxyapatite to obtain a bony seal; the second type was prepared for a polymethylmethacrylate seal; in the third type, the porous zone was surrounded by a 2-mm-thick space to allow the formation of a fibrous seal. Small polyethylene particles were injected into the knees once a week during the third and fourth months after implantation. The animals were euthanized 2 months later. Major longitudinal sections of the implants and the surrounding bone were examined under a polarized light microscope. Birefringent particles were counted at the cement-bone and cement-implant interfaces. Osteolysis was not observed. None of the seals significantly decreased the migration of particles around the cemented part of the implants. Particles were observed in cement fissures and vacuoles. They migrated at both interfaces and in the bone itself. They were visible in marrow spaces between bone trabeculae.
authors.affiliation: Department of Orthopaedic Surgery, Angers University Hospital, 4 rue Larrey, 49033 Angers Cedex 01, France. PhMassin@chu-angers.fr
authors.forename: P
authors.initials: P
authors.lastname: Massin
authors.forename: E
authors.initials: E
authors.lastname: Viguier
authors.forename: B
authors.initials: B
authors.lastname: Flautre
authors.forename: P
authors.initials: P
authors.lastname: Hardouin
authors.forename: E
authors.initials: E
authors.lastname: Astoin
authors.forename: B
authors.initials: B
authors.lastname: Duponchel
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D020959:Polyethylene / Q000378:metabolism*; D019736:Prostheses and Implants / Q000662:veterinary; D012756:Sheep / Q000378:metabolism
chemical_list: D020959:Polyethylene