Role of some fermentation parameters on cyclosporin A production by a new isolate of Aspergillus terreus.
A local isolate of Aspergillus terreus was selected among different microorganisms as a new cyclosporin A (Cy A) producing culture. The formation of Cy A was investigated under different fermentation conditions (including selection of the cultivation medium, fermentation time course, inoculum nature, medium volume, agitation rate, pH value). Relatively high Cy A productivities were maintained when the fermentation process was carried out using a medium composed of (g/L): glucose, 50; bactopeptone, 10; KH(2)PO(4), 5; KCl, 2.5; pH 5.3, inoculated with 2% standard inoculum of 48 h age, shaken at 200 rpm for 10 days.
Sallam
Lotfy A R
LA
Microbial and Natural Products Chemistry Department, National Research Centre, Dokki, Cairo, Egypt.
El-Refai
Abdel-Monem H
AM
Hamdy
Abdel-Hamid A
AH
El-Minofi
Hassaan A
HA
Abdel-Salam
Ibrahim S
IS
D001230:Aspergillus / Q000145:classification / Q000254:growth & development / Q000302:isolation & purification / Q000502:physiology*; D018533:Biomass; D016572:Cyclosporine / Q000378:metabolism*; D004534:Egypt; D005285:Fermentation; D007700:Kinetics; D013045:Species Specificity
D016572:Cyclosporine