Lovastatin inhibits its own synthesis in Aspergillus terreus.
Lovastatin suppresses its own synthesis in the microfungus Aspergillus terreus. The inhibitory effect was documented by spiking identical batch cultures with pure lovastatin (0, 50, 100 and 250 mg/l) 24 h after initiation from spores.
Casas López
J L
JL
Department of Chemical Engineering, University of Almería, 04120, Almería, Spain. jlcasas@ual.es
Rodríguez Porcel
E M
EM
Vilches Ferrón
M A
MA
Sánchez Pérez
J A
JA
Fernández Sevilla
J M
JM
Chisti
Y
Y
D000970:Antineoplastic Agents / Q000378:metabolism* / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects / Q000378:metabolism*; D001709:Biotechnology; D025461:Feedback, Physiological; D005285:Fermentation; D008148:Lovastatin / Q000096:biosynthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D008148:Lovastatin