Synthesis and antihypertensive activity of 1-(2-thiazolyl)-3, 5-disubstituted -2-pyrazolines.
Several substituted 3-aryl-1-(4-aryl-2-thiazolyl)-5-(3-pyridyl)-2-pyrazolines were synthesized by reacting substituted 3-aryl-5-(3-pyridyl)-1-thiocarbamoyl-2-pyrazolines with phenacyl bromide in ethanol. The structures of all compounds were confirmed by IR, (1)H-NMR, mass spectral data and elemental analyses. The antihypertensive activity of compounds was examined by the tail-cuff method and compared with clonidine. Compounds 24-28 showed significant antihypertensive activity.
Bagheri
Maryam
M
Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Shekarchi
Maryam
M
Jorjani
Masoumeh
M
Ghahremani
Mohammad Hossein
MH
Vosooghi
Mohssen
M
Shafiee
Abbas
A
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000008:administration & dosage / Q000493:pharmacokinetics; D007022:Hypotension / Q000139:chemically induced; D007274:Injections, Intraperitoneal; D008297:Male; D015394:Molecular Structure; D011720:Pyrazoles / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D021281:Quantitative Structure-Activity Relationship; D051381:Rats; D017207:Rats, Sprague-Dawley; D013844:Thiazoles / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000493:pharmacokinetics*
D000959:Antihypertensive Agents; D011720:Pyrazoles; D013844:Thiazoles; D003000:Clonidine