No major effect of orciprenaline and propranolol upon ACTH-induced cortisol secretion.
Preclinical research suggests adrenal beta-adrenergic receptors to be involved in the regulation of steroid synthesis. In a group of healthy male volunteers, we compared ACTH-induced cortisol and dehydroepiandrosterone (DHEA) secretion after pre-treatment with orciprenaline, propranolol or placebo. Neither baseline nor ACTH-induced steroid secretion differed between these conditions. Our data do not support the hypothesis that the adrenal beta-receptor plays a major role in steroid secretion in humans.
Nonell
A
A
Central Institute of Mental Health, Mannheim, Germany.
Kerk
S
S
Lederbogen
F
F
Kopf
D
D
Hamann
B
B
Lewicka
S
S
Deuschle
M
M
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000324:Adrenocorticotropic Hormone / Q000378:metabolism / Q000502:physiology*; D000328:Adult; D003366:Cosyntropin / Q000378:metabolism; D003687:Dehydroepiandrosterone / Q000097:blood / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D008297:Male; D009921:Metaproterenol / Q000494:pharmacology*; D010913:Pituitary-Adrenal System / Q000378:metabolism; D011433:Propranolol / Q000494:pharmacology*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects
D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D011943:Receptors, Adrenergic, beta; D003366:Cosyntropin; D003687:Dehydroepiandrosterone; D009921:Metaproterenol; D000324:Adrenocorticotropic Hormone; D011433:Propranolol; D006854:Hydrocortisone