Helicobacter pylori and molecular mechanisms of gastric carcinogenesis: targets for prevention and therapy.
Gastric cancer is still a leading cause of cancer death worldwide. It is frequently diagnosed in an advanced stage and the overall prognosis is dismal. A major improvement will only be reached with a better understanding of the genetic changes underlying gastric cancer, which may provide us with effective prevention and treatment strategies. This review will highlight the present knowledge on the role of Helicobacter pylori in gastric carcinogenesis and the molecular pathogenesis of gastric cancer, as well as provide a brief overview of possible future targets for more specific and successful treatment options.
Juhász
Márk
M
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke Uiversity, Leipzigerstr. 44, D-39120 Magdeburg, Germany.
Herszényi
László
L
Tulassay
Zsolt
Z
Malfertheiner
Peter
P
Ebert
Matthias P A
MP
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D017209:Apoptosis; D002448:Cell Adhesion; D002455:Cell Division; D005753:Gastric Mucosa / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D013274:Stomach Neoplasms / Q000235:genetics* / Q000517:prevention & control*
D020533:Angiogenesis Inhibitors