title: fexA, a novel Staphylococcus lentus gene encoding resistance to florfenicol and chloramphenicol.
abstract: The Staphylococcus lentus plasmid pSCFS2 carries a novel florfenicol-chloramphenicol resistance gene, designated fexA, encoding a protein of 475 amino acids with 14 transmembrane domains. The FexA protein differs from all previously known proteins involved in the efflux of chloramphenicol and florfenicol. Induction of fexA expression by chloramphenicol and florfenicol occurs via translational attenuation.
authors.affiliation: Institut für Tierzucht, Bundesforschungsanstalt für Landwirtschaft, 31535 Neustadt-Mariensee, Germany.
authors.forename: Corinna
authors.initials: C
authors.lastname: Kehrenberg
authors.forename: Stefan
authors.initials: S
authors.lastname: Schwarz
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001483:Base Sequence; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology; D002701:Chloramphenicol / Q000494:pharmacology*; D015246:Deoxyribonuclease EcoRI / Q000235:genetics; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000187:drug effects; D005798:Genes, Bacterial / Q000235:genetics*; D008969:Molecular Sequence Data; D012141:Respiratory Tract Infections / Q000382:microbiology / Q000662:veterinary; D013203:Staphylococcal Infections / Q000382:microbiology / Q000662:veterinary; D013210:Staphylococcus / Q000187:drug effects* / Q000235:genetics*; D013839:Thiamphenicol / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002701:Chloramphenicol; C035534:florfenicol; D015246:Deoxyribonuclease EcoRI; D013839:Thiamphenicol