title: Synthesis and mitochondrial complex I inhibition of dihydroxy-cohibin A, non-THF annonaceous acetogenin analogue.
abstract: To elucidate the inhibitory action of acetogenins, we synthesized an acetogenin derivative which possesses tetraol in place of the tetrahydrofuran ring and examined its inhibitory activity against bovine heart mitochondrial complex I. Our results indicate that these hydroxy groups are an essential structural factor though it is not effective as bis-THF hydroxy groups combination.
authors.affiliation: Department of Biological Science and Technology, Faculty of Engineering, University of Tokushima, 2-1Minamijosanjima-cho, Tokushima 770-8506, Japan. konno@bio.tokushima-u.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Konno
authors.forename: Naoki
authors.initials: N
authors.lastname: Hiura
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Makabe
authors.forename: Masato
authors.initials: M
authors.lastname: Abe
authors.forename: Hideto
authors.initials: H
authors.lastname: Miyoshi
mesh_terms: D054378:Acetogenins; D000818:Animals; D002417:Cattle; D042967:Electron Transport Complex I / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D005233:Fatty Alcohols / Q000138:chemical synthesis* / Q000494:pharmacology*; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006878:Hydroxides / Q000737:chemistry; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology*; D008929:Mitochondria, Heart / Q000201:enzymology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013367:Submitochondrial Particles / Q000201:enzymology
chemical_list: D054378:Acetogenins; D004791:Enzyme Inhibitors; D005233:Fatty Alcohols; D005663:Furans; D006878:Hydroxides; D007783:Lactones; C031356:hydroxide ion; D042967:Electron Transport Complex I