title: The effect of highly active antiretroviral therapy on dermatologic disease in a longitudinal study of HIV type 1-infected women.
abstract: The effect of highly active antiretroviral therapy (HAART) on skin diseases was evaluated in 878 human immunodeficiency virus type 1 (HIV-1)-infected women in the Women's Interagency HIV Study, a multicenter prospective study. HIV-1-infected women receiving HAART were less likely to have eczema, folliculitis, tinea pedis, and xerosis than were women who had not initiated HAART, independent of CD4+ cell count. Participants who had a prior history of a nadir CD4+ cell count of <200 cells/microL and recent CD4+ cell counts of 200-349 cells/microL were more likely to have eczema and xerosis than were women with a nadir CD4+ cell count of >200 cells/microL and recent CD4+ cell counts of >349 cells/microL. An HIV-1 RNA load of >100,000 copies/mL was associated with increased prevalence of herpes zoster infection (odds ratio, 6.10; 95% confidence interval, 2.00-18.65). History of injection drug use was associated with a higher prevalence of onychomycosis, tinea pedis, and xerosis. Molluscum contagiosum was more prevalent among younger women.
authors.affiliation: Department of Dermatology, University of California, San Francisco, California, USA. tmaurer@itsa.ucsf.edu
authors.forename: Toby
authors.initials: T
authors.lastname: Maurer
authors.forename: Lori K E
authors.initials: LK
authors.lastname: Rodrigues
authors.forename: Niloufar
authors.initials: N
authors.lastname: Ameli
authors.forename: Nittaya
authors.initials: N
authors.lastname: Phanuphak
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Gange
authors.forename: Jack
authors.initials: J
authors.lastname: DeHovitz
authors.forename: Audrey L
authors.initials: AL
authors.lastname: French
authors.forename: Marshall
authors.initials: M
authors.lastname: Glesby
authors.forename: Carol
authors.initials: C
authors.lastname: Jordan
authors.forename: Ann
authors.initials: A
authors.lastname: Khalsa
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Hessol
mesh_terms: D000293:Adolescent; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D003881:Dermatomycoses / Q000150:complications / Q000453:epidemiology* / Q000276:immunology / Q000382:microbiology; D004485:Eczema / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D008137:Longitudinal Studies; D008875:Middle Aged; D014009:Onychomycosis / Q000453:epidemiology; D015995:Prevalence; D011446:Prospective Studies; D014008:Tinea Pedis / Q000453:epidemiology; D016387:Women's Health