Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor kappa B (NF-kappaB).
Over the last 10 years, a significant body of evidence has emerged indicating that chemically diverse classes of naturally-occurring substances derived from higher plants are of potential interest for therapeutic interventions in several inflammatory diseases. Part I of this review article focuses on our current knowledge of the mechanisms by which a large range of plant-derived constituents interfere with three relevant targets involved in the inflammatory process, namely arachidonic acid metabolite pathways, nitric oxide and NF-kappaB, and discusses their potential therapeutic use in the management of relevant inflammatory diseases.
Calixto
João B
JB
Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. calixto@farmaco.ufsc.br
Otuki
Michel F
MF
Santos
Adair R S
AR
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000378:metabolism*; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D008517:Phytotherapy; D010946:Plants, Medicinal
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016328:NF-kappa B; D016718:Arachidonic Acid; D019001:Nitric Oxide Synthase