Contemporaneous appearance, 18 years after allogeneic bone marrow transplantation, of myelodysplastic syndrome in the patient and the donor.
We report the case of the development of two different stages of the same clonal disorder in two patients sharing the same bone marrow due to a previous bone marrow allotransplant. The transplanted patient developed severe aplasia with myeloid blasts, different from those of the previously cured leukemia. Chimerism evaluated by microsatellite analyses confirmed a full donor phenotype. At the same time, the donor of the bone marrow transplantation developed a refractory anemia with excess blasts. We speculate on the presence of an undetectable pre-existing pathological clone in the transplanted bone marrow, which have evolved in the two patients.
Orciuolo
E
E
Department of Oncology, Transplant and Advances in Medicine, Section of Hematology, University of Pisa, St Chiara Hospital, Pisa, Italy.
Azzarà
A
A
Bandini
G
G
Galimberti
S
S
Bonifazi
F
F
Fazzi
R
R
Petrini
M
M
D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000628:therapy; D009190:Myelodysplastic Syndromes / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D035781:Siblings; D013997:Time Factors; D014019:Tissue Donors; D018183:Transplantation Chimera / Q000235:genetics; D014184:Transplantation, Homologous