Molecular genetics of human prostate cancer.
Multiple factors contribute to the high incidence and prevalence of prostate cancer including race, ethnicity, diet, environment, widespread awareness through prostate-specific antigen screening and genetics. Linkage analysis has identified several candidate sites for hereditary prostate cancer gene loci. Molecular studies have also identified genes that are frequently altered in sporadic prostate cancer. It appears that due to the heterogeneity of prostate cancer, multiple genes may be involved in the neoplastic process.
Rubin
Mark A
MA
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA. marubin@partners.org
De Marzo
Angelo M
AM
D043171:Chromosomal Instability; D019295:Computational Biology; D018450:Disease Progression; D004210:Dissection; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008967:Molecular Biology; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000503:physiopathology; D040901:Proteomics; D011944:Receptors, Androgen / Q000378:metabolism; D016615:Telomere
D011944:Receptors, Androgen