title: Preparation and study on the novel solid inclusion complex of ciprofloxacin with HP-beta-cyclodextrin.
abstract: The interaction of ciprofloxacin with HP-beta-cyclodextrin (HP-beta-CD) has been studied by several analytical techniques, including 1H nuclear magnetic resonance (NMR), 13C NMR, fluorescence spectra, infrared spectroscopy, thermal analyzer and scanning electron microscope. In this paper, solid inclusion complex of ciprofloxacin with HP-beta-CD was synthesized by the coprecipitation method. In addition, the characterization of the inclusion complex has been proved by fluorimetry, infrared, differential scanning calorimetry and one-dimensional (1D), 2D NMR. The experimental results confirmed the existence of 1:1 inclusion complex of ciprofloxacin with HP-beta-CD. The formation constant of complex was determined by fluorescence method and 1H NMR. Spacial configuration of complex has been proposed on two-dimensional NMR technique.
authors.affiliation: The Test and Analysis Center of Shanxi University, TaiYuan 030006, PR China.
authors.forename: Jianbin
authors.initials: J
authors.lastname: Chao
authors.forename: Dongping
authors.initials: D
authors.lastname: Meng
authors.forename: Jiangsong
authors.initials: J
authors.lastname: Li
authors.forename: Hao
authors.initials: H
authors.lastname: Xu
authors.forename: Shuping
authors.initials: S
authors.lastname: Huang
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002152:Calorimetry, Differential Scanning; D002939:Ciprofloxacin / Q000737:chemistry* / Q000378:metabolism; D003505:Cyclodextrins / Q000737:chemistry* / Q000378:metabolism; D005470:Fluorometry; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D047392:beta-Cyclodextrins
chemical_list: D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002939:Ciprofloxacin