[Immune system senescence and mortality dynamics. Role of antigenic load].
This paper is dedicated to investigation of the impact of total antigenic load on immunosenescence. Data on pneumonia mortality have been simulated. The results of modelling revealed that antigenic load as well as probability of infecting could account for the shifting in mortality that takes place for different countries. Dynamics of immunosenescence is described by mathematical model for age related changes in T-cell populations. Numerical simulation of the model yields estimates for pneumonia severity at different ages. Probability function is used to describe relationship between pneumonia mortality and age related changes in disease severity.
Sannikova
T E
TE
Institute of Numerical Mathematics, RAS, 8, Gubkina str., Moscow, 119991. tatiana@inm.ras.ru
Marchuk
G I
GI
Romaniukha
A A
AA
Iashin
A I
AI
D000368:Aged; D000375:Aging / Q000276:immunology*; D000941:Antigens / Q000276:immunology*; D006801:Humans; D018448:Models, Immunological; D011014:Pneumonia / Q000276:immunology / Q000401:mortality*; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens