[A case of chronic cerebellitis with anti-glutamate receptor delta 2 antibody].
A 1-year-8-month-old patient developed cerebellar ataxia following a prodromal infection. Despite initial diagnosis of acute cerebellar ataxia, his symptoms lasted for more than 30 days. High-dose intravenous immunoglobulin and steroid pulse therapy failed to ameliorate his cerebellar symptoms, which fluctuated in association with infections. At the age of 3 years and 8 months, he had mental retardation with cerebellar symptoms. Findings of MR imaging and single photon emission computed tomography were normal. Neuron-specific enolase of cerebrospinal fluid (CSF) ranged from 10.4-17.6 ng/ml, correlating with the cerebellar symptoms. Serum and CSF anti-glutamate receptor delta 2 antibodies were detected in the serum and CSF. We diagnosed him as having chronic cerebellitis associated with anti-glutamate receptor delta 2 antibody.
Sugiyama
Nobuyoshi
N
Division of Neurology, Saitama Children's Medical Center, Iwatsuki, Saitama. nobuyosi@is.icc.u-tokai.ac.jp
Hamano
Shin-ichiro
S
Mochizuki
Mika
M
Tanaka
Manabu
M
Takahashi
Yukitoshi
Y
D001323:Autoantibodies / Q000009:adverse effects* / Q000097:blood / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000097:blood / Q000134:cerebrospinal fluid; D002524:Cerebellar Ataxia / Q000209:etiology; D002526:Cerebellar Diseases / Q000175:diagnosis* / Q000209:etiology*; D002675:Child, Preschool; D002908:Chronic Disease; D006801:Humans; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid; D017470:Receptors, Glutamate / Q000276:immunology*
D001323:Autoantibodies; D015415:Biomarkers; D017470:Receptors, Glutamate; C107913:glutamate receptor delta 2; D010751:Phosphopyruvate Hydratase