Rapid methylation of terminal acetylenes by the Stille coupling of methyl iodide with alkynyltributylstannanes: a general protocol potentially useful for the synthesis of short-lived 11CH3-labeled PET tracers with a 1-propynyl group.
The Pd(0)-mediated rapid coupling (trapping) reaction of methyl iodide with an excess amount of alkynyltributylstannane has been developed with the aim to incorporate a short-lived (11)C-labeled methyl group into biologically active organic compounds with a 1-propynyl structural unit.
Hosoya
Takamitsu
T
Division of Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu, Japan.
Wakao
Masahiro
M
Kondo
Yurie
Y
Doi
Hisashi
H
Suzuki
Masaaki
M