[Experimental characteristics of the neurotropic spectrum of some antiepileptic agents].
Investigation of the psychotropic spectrum of phenobarbital, diphenin, milontin, pufemide, sodium valproate (depakine), and diazeparn showed that, besides antagonism with the corazole and electroshock effects, all these drugs prevented to a considerable degree the kindling seizures in rats on a "tonsil swing" (chronic electroencephalographic partial epilepsy) model. The mechanism of this effect probably involves exciting amino acids. All anticonvulsants except for diazepam also restored memory in experimental animals with retrograde electroshock amnesia. The administration of diazepam, diphenin, and sodium valproate to rats with kindling convulsions led to activation of the spontaneous horizontal motions in the open-field test, which can be explained by the presence of antianxiety component in the drug action.
Dzhagatspanian
I A
IA
Laboratory of Psychopharmacology, Mndzhoyan Institute of Fine Organic Chemistry, National Academy of Sciences of Armenia, prosp. Azatutyan 26, Yerevan, 375001 Armenia.
Paronikian
R G
RG
Nazarian
I M
IM
D000648:Amnesia, Retrograde / Q000188:drug therapy; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000927:Anticonvulsants / Q000494:pharmacology*; D003292:Convulsants / Q000037:antagonists & inhibitors; D004597:Electroshock; D007696:Kindling, Neurologic; D008568:Memory / Q000187:drug effects; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000188:drug therapy / Q000209:etiology
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D003292:Convulsants; D011619:Psychotropic Drugs; D010433:Pentylenetetrazole