Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening.
Müller
Oliver
O
Max-Planck-Institut für molekulare Physiologie, Abteilung Strukturelle Biologie, Dortmund, Germany.
Gourzoulidou
Eleni
E
Carpintero
Mercedes
M
Karaguni
Ioanna-Maria
IM
Langerak
Anette
A
Herrmann
Christian
C
Möröy
Tarik
T
Klein-Hitpass
Ludger
L
Waldmann
Herbert
H
D000818:Animals; D017304:Annexin A5 / Q000032:analysis / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D017209:Apoptosis / Q000502:physiology; D002455:Cell Division / Q000187:drug effects / Q000502:physiology; D002460:Cell Line; D002461:Cell Line, Transformed; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D020650:Combinatorial Chemistry Techniques; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D004847:Epithelial Cells / Q000187:drug effects; D011905:Genes, ras / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D020128:Inhibitory Concentration 50; D008856:Microscopy, Fluorescence; D010641:Phenotype; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology; D013329:Structure-Activity Relationship; D013467:Sulindac / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D051153:Wnt Proteins; D029961:Zebrafish Proteins
D017304:Annexin A5; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D013467:Sulindac