title: Testicular cancer metastatic exclusively to the brain and spleen.
abstract: We report an unusual case of testicular cancer metastasized solely in the brain and spleen without retroperitoneal disease or other widespread metastasis. The patient initially presented with seizures and underwent craniotomy for presumed primary brain tumor, with a delayed diagnosis of testicular cancer as the true primary. This pattern of spread is highly unusual, and, to our knowledge, we report the first case of splenectomy performed for involvement by testicular cancer. At last follow-up, the patient was doing well, with no evidence of disease after 2 years.
authors.affiliation: Department of Urology, University of California, Davis, School of Medicine, Sacramento, California 95817, USA.
authors.forename: Mike M
authors.initials: MM
authors.lastname: Nguyen
authors.forename: Alan S
authors.initials: AS
authors.lastname: Corr
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Evans
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003399:Craniotomy; D003937:Diagnosis, Differential; D018240:Endodermal Sinus Tumor / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D005047:Etoposide / Q000008:administration & dosage; D005625:Frontal Lobe / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009919:Orchiectomy; D012074:Remission Induction; D012640:Seizures / Q000209:etiology; D018239:Seminoma / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D015173:Supratentorial Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D013724:Teratoma / Q000175:diagnosis / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D013736:Testicular Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D014463:Ultrasonography
chemical_list: D001761:Bleomycin; D005047:Etoposide; D002945:Cisplatin