Pharmacokinetic study and trial for preparation of enteric-coated capsule containing insulinomimetic vanadyl compounds: implications for clinical use.
To treat patients suffering from diabetes mellitus, we developed several types of orally active vanadyl complexes to replace painful insulin injections, and prepared them in the form of enteric-coated capsules containing vanadium compounds. Pharmacokinetic analysis demonstrated that these capsules enhance the bioavailability of pharmacologically active vanadyl species.
Sakurai
Hiromu
H
Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan. sakurai@mb.kyoto-phu.ac.jp
Fugono
Jun
J
Yasui
Hiroyuki
H
D000284:Administration, Oral; D000818:Animals; D002214:Capsules; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D005780:Gelatin / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics; D010848:Picolinic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D014638:Vanadates / Q000008:administration & dosage / Q000493:pharmacokinetics; D017968:Vanadium Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use
D002214:Capsules; D007004:Hypoglycemic Agents; D009942:Organometallic Compounds; D010848:Picolinic Acids; D017968:Vanadium Compounds; C402804:bis(6-methylpicolinato)oxovanadium(IV); C095866:bis(picolinato)oxovanadium(IV); D014638:Vanadates; C034028:vanadyl sulfate; D005780:Gelatin