[Bone mineral density in school age children born preterm ].
BACKGROUND
The age at which children born preterm normalize their bone mineral density, is not well known.


OBJECTIVE
To study if children born preterm have normalized their bone mineral density at age 5 to 7 years.


METHODS
Twenty six infants born preterm (14 male), were studied at age 5 to 7 years. Birth weight, present weight and height, bone age, calcium and phosphate intake at the first year of life and at the current age were assessed. Bone mineral density was measured by single photon X ray absorptiometry in the dominant forearm. A blood sample was obtained to measure insulin growth factor 1 (IGF-1). As a control group, 105 healthy age-paired infants born at term, were studied.


RESULTS
Bone mineral density was significantly lower in infants born preterm than in their term counterparts (0.273 +/- 0.01 g/cm2 and 0.302 +/- 0.01 g/cm2 respectively, p < 0.001). There was a positive correlation between bone mineral density and IGF-1 (r = 0.49, p = 0.01). No correlation with the other measured parameters was observed.


CONCLUSIONS
Infants that were born preterm have a lower bone mineral density at 5 to 7 years of age than their term controls. Bone mineral density correlates with IGF-1.
Milinarsky
Aída
A
Departamentos de Pediatría y Medicina, Facultad de Medicina, Universidad de Valparaíso, Chile. pediatria@uv.cl
Fischer
Sylvia
S
Giadrosich
Vinka
V
Hernández
María Isabel
MI
Torres
María Teresa
MT
D000886:Anthropometry; D001724:Birth Weight / Q000502:physiology*; D015519:Bone Density; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008297:Male; D018709:Statistics, Nonparametric