title: Central role of the P2Y12 receptor in platelet activation.
abstract: Platelet activation occurs in response to vessel injury and is important for the arrest of bleeding. Platelet activation during disease states leads to vascular occlusion and ischemic damage. The P2Y(12) receptor, activated by ADP, plays a central role in platelet activation and is the target of P2Y(12) receptor antagonists that have proven therapeutic value.
authors.affiliation: Department of Pharmacology, Temple University Medical School, Philadelphia, Pennsylvania 19140, USA.
authors.forename: Robert T
authors.initials: RT
authors.lastname: Dorsam
authors.forename: Satya P
authors.initials: SP
authors.lastname: Kunapuli
mesh_terms: D000244:Adenosine Diphosphate / Q000378:metabolism; D001760:Bleeding Time; D001777:Blood Coagulation / Q000502:physiology; D001792:Blood Platelets / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D015539:Platelet Activation / Q000502:physiology*; D018048:Receptors, Purinergic P2 / Q000378:metabolism*; D058925:Receptors, Purinergic P2Y12
chemical_list: D008565:Membrane Proteins; C548576:P2RY12 protein, human; D018048:Receptors, Purinergic P2; D058925:Receptors, Purinergic P2Y12; D000244:Adenosine Diphosphate