title: Characteristics of radiogenic lower motor neurone disease, a possible link with a preceding viral infection.
abstract: OBJECTIVE
  To investigate the pathogenesis of the rare radiogenic lower motor neurone disease (LMND) on the basis of a meta-analysis of the published case histories.
  
  
  METHODS
  The authors reviewed 47 well-documented radiogenic LMND cases from the English literature.
  
  
  RESULTS
  The disease typically occurs following the irradiation of radiosensitive cancers situated near the spinal cord. It arises predominantly (46 cases) in the lower extremities; only one case involved the upper extremities. There is a male predominance (male:female ratio 7.8:1), and the patients are characteristically young (13-40 years, with four exceptions). An overdose does not seem to be a particular risk factor for the development of the disease, as total dose, fraction size and biologically effective dose are typically below 50 Gy, 2 Gy and 128 Gy2, respectively, which are regarded as safe doses. Other risk factors (chemotherapy, operations, etc) have been identified only rarely. Radiogenic LMND is manifested in an apparently random manner, 4-312 (mean 48.7) months after the completion of radiotherapy.
  
  
  CONCLUSIONS
  The complete lack of a dose-effect relationship argues strongly against a pure radiogenic nature of the pathological process. The latency period is typically several years and it varies extremely, which excludes a direct and complete causal relationship between radiotherapy and LMND. As the interaction of ionizing radiation with living tissues is highly unspecific, thus a selective motor injury due to irradiation alone, without comparable effects on the sensory and vegetative fibers, seems improbable.
  
  
  CONCLUSIONS
  On analogy with the viral motor neurone diseases, we suppose that radiogenic LMND may be preceded by viral (enterovirus/poliovirus) infection. Based on the meta-analysis, it is suggested that irradiation may be only a single component of the set of factors jointly resulting in the clinical state regarded as radiogenic LMND.
authors.affiliation: Department of Oncotherapy, Semmelweis University, Hungary.
authors.forename: O
authors.initials: O
authors.lastname: Esik
authors.forename: K
authors.initials: K
authors.lastname: Vönöczky
authors.forename: Z
authors.initials: Z
authors.lastname: Lengyel
authors.forename: G
authors.initials: G
authors.lastname: Sáfrány
authors.forename: L
authors.initials: L
authors.lastname: Trón
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000870:Anterior Horn Cells / Q000503:physiopathology / Q000528:radiation effects* / Q000821:virology*; D015984:Causality; D020805:Central Nervous System Viral Diseases / Q000150:complications*; D064420:Drug-Related Side Effects and Adverse Reactions; D004769:Enterovirus Infections / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000453:epidemiology / Q000503:physiopathology / Q000821:virology*; D009369:Neoplasms / Q000532:radiotherapy; D011051:Poliomyelitis / Q000150:complications; D011829:Radiation Dosage; D011878:Radiotherapy / Q000009:adverse effects*; D011930:Reaction Time / Q000502:physiology / Q000528:radiation effects; D012737:Sex Factors