Yeasts from the oral cavity of children with AIDS: exoenzyme production and antifungal resistance.
The oral fungal microbiota of 30 children with AIDS, of both genders, aged from two to six years, receiving outpatient treatment, was evaluated and compared with that of a control group composed of 30 healthy subjects with matching ages and genders. Virulence factors, such as exoenzyme production, and susceptibility to five antifungal agents using an E-Test kit were evaluated. C. albicans predominated over other species in the AIDS group, showing a higher production of proteinase and phospholipase when compared with that observed in the control group. In this study few clinical manifestations of and low selectivity for C. albicans (23.3%) were observed in the AIDS group. The enzymatic studies showed that 53.8% of the AIDS strains were strongly positive whereas only 33.3% of the non-AIDS strains were positive. Amphotericin B was the most effective drug among the antifungal agents tested against C. albicans. The frequency, selectivity and level of exoenzyme production by C. albicans suggest a higher pathogenicity in the AIDS children than in the control children.
Bosco
Vera Lúcia
VL
School of Dentistry, Federal University of Santa Catarina, Brazil.
Birman
Esther Goldenberg
EG
Cury
Arlete Emily
AE
Paula
Claudete Rodrigues
CR
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology / Q000382:microbiology; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000382:microbiology*; D000935:Antifungal Agents / Q000494:pharmacology*; D018791:CD4 Lymphocyte Count; D002176:Candida albicans / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification; D002180:Candidiasis, Oral / Q000276:immunology / Q000382:microbiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D025141:Drug Resistance, Fungal; D010450:Endopeptidases / Q000096:biosynthesis; D005260:Female; D006801:Humans; D006867:Hydrolases / Q000096:biosynthesis*; D008297:Male; D009055:Mouth / Q000382:microbiology*; D010740:Phospholipases / Q000096:biosynthesis; D015003:Yeasts / Q000187:drug effects / Q000201:enzymology / Q000302:isolation & purification
D000935:Antifungal Agents; D006867:Hydrolases; D010740:Phospholipases; D010450:Endopeptidases