A lazaroid mitigates postresuscitation myocardial dysfunction.
OBJECTIVE
Lazaroids, a series of 21-aminosteroids, reduce free radical mediated injury after ischemia and reperfusion. We hypothesized that the lazaroid U-74389G would minimize postresuscitation myocardial dysfunction and thereby improve neurologically meaningful survival in a rodent model after resuscitation from 8 mins of ventricular fibrillation.


METHODS
Randomized, controlled laboratory study.


METHODS
University-affiliated research institute.


METHODS
Sprague-Dawley rats.


METHODS
Ventricular fibrillation was electrically induced in ten anesthetized Sprague-Dawley rats. The lazaroid agent U-74389G in a dose of 1 mg.kg-1 or its vehicle serving as a placebo was injected into the right atrium after 7 mins of untreated ventricular fibrillation. One minute after injection of the compound, precordial compression was begun together with mechanical ventilation and continued for 6 mins before attempted electrical defibrillation.


RESULTS
All animals were successfully resuscitated. Postresuscitation cardiac index, left ventricular end-diastolic pressure, the rate of left ventricular pressure increase measured at a left ventricular pressure of 40 mm Hg, and the maximum rate of left ventricular pressure decline were significantly less impaired in lazaroid-treated animals. This contrasted with control animals, which had significantly greater myocardial impairment, greater neurologic deficit, and lesser duration of survival.


CONCLUSIONS
The lazaroid compound U-74389G, administered during cardiac arrest, mitigated postresuscitation myocardial dysfunction and improved survival.
Wang
Jinglan
J
Institute of Critical Care Medicine, Palm Springs, CA, USA.
Weil
Max Harry
MH
Kamohara
Takashi
T
Tang
Wanchun
W
Sun
Shijie
S
Klouche
Kada
K
Bisera
Joe
J
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D009202:Cardiomyopathies / Q000188:drug therapy*; D008297:Male; D011281:Pregnatrienes / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012151:Resuscitation
D000975:Antioxidants; D011281:Pregnatrienes; C074965:U 74389F