title: In vitro activity of BAL9141 against clinical isolates of gram-negative bacteria.
abstract: The minimum inhibitory concentration and minimum bactericidal concentration of BAL9141 against 150 clinical isolates of gram-negative bacteria were determined and compared to those of cefepime and ceftriaxone. BAL9141 exhibited comparable activity to cefepime and ceftriaxone against Haemophilus influenzae, Klebsiella pneumoniae, and extended-spectrum beta-lactamase nonproducing Enterobacter cloacae, and comparable activity to cefepime against Pseudomonas aeruginosa.
authors.affiliation: Department of Internal Medicine, Rochester, MN, USA.
authors.forename: Nicolas C
authors.initials: NC
authors.lastname: Issa
authors.forename: Mark S
authors.initials: MS
authors.lastname: Rouse
authors.forename: Kerryl E
authors.initials: KE
authors.lastname: Piper
authors.forename: Walter R
authors.initials: WR
authors.lastname: Wilson
authors.forename: James M
authors.initials: JM
authors.lastname: Steckelberg
authors.forename: Robin
authors.initials: R
authors.lastname: Patel
mesh_terms: D002511:Cephalosporins / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria / Q000145:classification / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D012494:Sampling Studies; D012680:Sensitivity and Specificity
chemical_list: D002511:Cephalosporins; C443755:ceftobiprole