title: Cytotoxic cardenolide glycoside from the seeds of Cerbera odollam.
abstract: A cardenolide glycoside, 3 beta-O-(2'-O-acetyl-l- thevetosyl)-15(14-->8)-abeo-5 beta-(8R)-14-oxo-card-20(22)-enolide (2'-O-acetyl cerleaside A), was isolated from a methylene chloride extract of the seeds of Cerbera odollam, together with four known compounds: cerleaside A, 17 alpha-neriifolin, 17 beta- neriifolin and cerberin. Their structures were elucidated by spectroscopic methods. All compounds except cerleaside A exhibited cytotoxic activities against oral human epidermoid carcinoma (KB), human breast cancer cell (BC) and human small cell lung cancer (NCI-H187).
authors.affiliation: Department of Chemistry, Faculty of Science, Prince of Songkla University, Hat-Yai, Songkhla 90112, Thailand.
authors.forename: Surat
authors.initials: S
authors.lastname: Laphookhieo
authors.forename: Sarot
authors.initials: S
authors.lastname: Cheenpracha
authors.forename: Chatchanok
authors.initials: C
authors.lastname: Karalai
authors.forename: Suchada
authors.initials: S
authors.lastname: Chantrapromma
authors.forename: Yanisa
authors.initials: Y
authors.lastname: Rat-a-Pa
authors.forename: Chanita
authors.initials: C
authors.lastname: Ponglimanont
authors.forename: Kan
authors.initials: K
authors.lastname: Chantrapromma
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D029062:Apocynaceae / Q000737:chemistry*; D002298:Cardenolides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry; D012639:Seeds / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002298:Cardenolides; D006027:Glycosides; D010936:Plant Extracts