Perirhinal cortex muscarinic receptor blockade impairs taste recognition memory formation.
The relevance of perirhinal cortical cholinergic and glutamatergic neurotransmission for taste recognition memory and learned taste aversion was assessed by microinfusions of muscarinic (scopolamine), NMDA (AP-5), and AMPA (NBQX) receptor antagonists. Infusions of scopolamine, but not AP5 or NBQX, prevented the consolidation of taste recognition memory using attenuation of neophobia as an index. In addition, learned taste aversion in both short- and long-term memory tests was exclusively impaired by scopolamine. These data provide neurochemical support for the theory that cholinergic activity of the perirhinal cortex participates in the formation of the taste memory trace and that it is independent of the NMDA and AMPA receptor activity. These results support the idea that cholinergic neurotransmission in the perirhinal cortex is also essential for acquisition and consolidation of taste recognition memory.
Gutiérrez
Ranier
R
Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, AP 70-253, 04510 Cd. México, DF, México.
De la Cruz
Vanesa
V
Rodriguez-Ortiz
Carlos J
CJ
Bermudez-Rattoni
Federico
F
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D018698:Glutamic Acid / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors / Q000502:physiology; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D021641:Recognition, Psychology / Q000187:drug effects* / Q000502:physiology; D012601:Scopolamine / Q000494:pharmacology*; D009435:Synaptic Transmission; D013649:Taste / Q000187:drug effects* / Q000502:physiology
D018691:Excitatory Amino Acid Antagonists; D018727:Muscarinic Antagonists; D011810:Quinoxalines; D018091:Receptors, AMPA; D011976:Receptors, Muscarinic; D016194:Receptors, N-Methyl-D-Aspartate; C062865:2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; D018698:Glutamic Acid; D015763:2-Amino-5-phosphonovalerate; D012601:Scopolamine; D000109:Acetylcholine