Peri-sciatic administration of indomethacin early after nerve injury can attenuate the development of tactile allodynia in a rat model of L5 single spinal nerve injury.
To clarify the role of cyclooxygenase in the peripheral nerve on the development of neuropathic pain, we investigated the effects of peri-sciatic administration of indomethacin on the development of allodynia in a model of L5 single spinal nerve injury. Peri-sciatic administration of indomethacin (1 mg/kg) was performed 3, 24, or 72 h after nerve injury (n=6/each). In rats with indomethacin 3 or 24 h after nerve injury, ipsi-lateral paw withdrawal thresholds 7-35 days after nerve injury were significantly higher compared with those in the control group (n=6: without peri-sciatic treatment) (P<0.05). However, such efficacy was no longer apparent when indomethacin was administered 72 h after nerve injury. These results suggest that peri-sciatic administration of indomethacin early (less than 24 h) after nerve injury can attenuate the development of allodynia.
Takahashi
Masahiro
M
Department of Pharmacology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara 634-8521, Japan.
Kawaguchi
Masahiko
M
Shimada
Keiji
K
Konishi
Noboru
N
Furuya
Hitoshi
H
Nakashima
Toshikatsu
T
D000818:Animals; D019771:Axotomy; D004195:Disease Models, Animal; D007213:Indomethacin / Q000008:administration & dosage*; D008159:Lumbar Vertebrae / Q000187:drug effects / Q000294:innervation; D008297:Male; D010147:Pain Measurement / Q000187:drug effects* / Q000379:methods; D010812:Physical Stimulation / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000187:drug effects* / Q000502:physiology*; D013127:Spinal Nerves / Q000187:drug effects / Q000502:physiology*; D014110:Touch / Q000502:physiology
D007213:Indomethacin