title: Tetrahydrofuran lignans from Nectandra megapotamica with trypanocidal activity.
abstract: The phytochemical investigation of the crude ethanol extract of the leaves of Nectandra megapotamica afforded three new (2d, 3b, and 3c) and eight known (1a-d, 2a-c, and 3a) tetrahydrofuran lignans. Regarding the in vitro trypanocidal activity, the lignan-rich fraction, at a concentration of 2.0 mg/mL, was 100% active. Compound 1a was the most active, showing an IC(50) value of 2.2 microM and lysis of 94% of the parasites at 32 microM. Compounds 1b, 1d, 2a, 2c, and 3a displayed moderate activity, while compound 1c was inactive.
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café S/N, Ribeirão Preto 14040-903, SP, Brazil.
authors.forename: Ademar A
authors.initials: AA
authors.lastname: da Silva Filho
authors.forename: Sérgio
authors.initials: S
authors.lastname: Albuquerque
authors.forename: Márcio L A e
authors.initials: ML
authors.lastname: Silva
authors.forename: Marcos N
authors.initials: MN
authors.lastname: Eberlin
authors.forename: Daniela M
authors.initials: DM
authors.lastname: Tomazela
authors.forename: Jairo K
authors.initials: JK
authors.lastname: Bastos
mesh_terms: D000818:Animals; D001938:Brazil; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D019770:Lauraceae / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D005663:Furans; D017705:Lignans; D014344:Trypanocidal Agents; C018674:tetrahydrofuran