Consensus design of repeat proteins.
Consensus design is a valuable protein-engineering method that is based on statistical information derived from sequence alignments of homologous proteins. Recently, consensus design was adapted to repeat proteins. We discuss the potential of this novel repeat-based approach for the design of consensus repeat proteins and repeat protein libraries and summarize recent results from such experiments.
Forrer
Patrik
P
Biochemisches Institut, Universität Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
Binz
H Kaspar
HK
Stumpp
Michael T
MT
Plückthun
Andreas
A
D016384:Consensus Sequence; D019151:Peptide Library; D011487:Protein Conformation; D015202:Protein Engineering / Q000379:methods*; D011506:Proteins / Q000737:chemistry*
D019151:Peptide Library; D011506:Proteins