title: Mixed meningeal and brain plasma-cell granuloma: an example of an unusual evolution.
abstract: We report a study of a 22-year-old woman with a plasma-cell granuloma (PCG), a rare intracranial lesion characterized by a non-neoplastic polyclonal proliferation of plasma cells and other mononuclear cells. She presented after a generalized seizure and CT-scan and magnetic resonance images demonstrated a left temporo-basal tumour mass involving both the meningeal layers and the brain parenchyma. Histopathological examination of a biopsy led to the diagnosis of a typical PCG. After a short course of steroid administration, the clinical and radiological features improved and complete regression of the lesion was shown after one year and persisted at four-year follow-up. This dramatic regression of an intracranial PCG shows that neither surgical removal nor radiation therapy is required to treat a broad skull base PCG.
authors.affiliation: Service de Neurochirurgie, Hôpital Sainte Marguerite, Marseille, France. PROCHE@mail.ap-hm.fr
authors.forename: P-H
authors.initials: PH
authors.lastname: Roche
authors.forename: D
authors.initials: D
authors.lastname: Figarella-Branger
authors.forename: W
authors.initials: W
authors.lastname: Pellet
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D006104:Granuloma, Plasma Cell / Q000188:drug therapy* / Q000473:pathology*; D006801:Humans; D008578:Meninges / Q000473:pathology*; D012640:Seizures / Q000209:etiology; D013256:Steroids / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D013256:Steroids