Significance of chymase inhibition for prevention of adhesion formation.
To clarify the role of chymase in adhesion formation, we investigated whether a chymase inhibitor could prevent adhesion formation after surgery in hamsters. Hamsters received a lesion produced by uterus scraping. A specific chymase inhibitor, 2-[4-(5-fluoro-3-methylbenzo[b]thiophen-2-yl)sulfonamido-3-methanesulfonylphenyl]oxazole-4-carboxylicacid (TY-51184), or placebo was injected into the abdomen before closing and scores for adhesion formation were assessed at 1, 4, and 12 weeks. A single peritoneal administration of TY-51184 significantly decreased the adhesion scores even at 12 weeks (placebo, 2.80+/-0.20; chymase inhibitor, 1.60+/-0.31). Thus, chymase inhibitors may be a novel strategy to prevent adhesion formation.
Okamoto
Yukiko
Y
Department of Pharmacology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki City, Osaka 589-8686, Japan.
Takai
Shinji
S
Miyazaki
Mizuo
M
D000818:Animals; D053818:Chymases; D006224:Cricetinae; D005260:Female; D008647:Mesocricetus; D010080:Oxazoles / Q000494:pharmacology / Q000627:therapeutic use; D010529:Peritoneal Cavity / Q000473:pathology / Q000601:surgery; D012697:Serine Endopeptidases / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D013449:Sulfonamides / Q000494:pharmacology / Q000627:therapeutic use; D000267:Tissue Adhesions / Q000201:enzymology* / Q000517:prevention & control*; D014599:Uterus / Q000187:drug effects / Q000201:enzymology / Q000473:pathology / Q000601:surgery
C487109:2-(4-(5-fluoro-3-methylbenzo(b)thiophen-2-yl)sulfonamide-3-methanesulfonylphenyl)oxazole-4-carboxylic acid; D010080:Oxazoles; D015842:Serine Proteinase Inhibitors; D013449:Sulfonamides; D012697:Serine Endopeptidases; D053818:Chymases