Prior DNA vaccination does not interfere with the live-attenuated measles vaccine.
The currently used live-attenuated measles vaccine is very effective although maternal antibody prevents its administration prior to 6 months of age. We are investigating the ability of a DNA vaccine encoding the measles viral hemagglutinin, fusion and nucleoprotein to protect newborn infants from measles. Here, we show that a measles DNA vaccine protects juvenile macaques from pathogenic measles virus challenge and that macaques primed and boosted with this DNA vaccine have anemnestic antibody and cell-mediated responses after vaccination with a live-attenuated canine distemper-measles vaccine. Therefore, this DNA vaccine administered to newborn infants may not hinder the subsequent use of live-attenuated measles vaccine.
Premenko-Lanier
Mary
M
Department of Pathology, California National Primate Research Center, School of Medicine, University of California-Davis, County Road 98 and Hutchison Drive, Davis, CA 95616-8542, USA.
Rota
Paul
P
Rhodes
Gary
G
Bellini
William
W
McChesney
Michael
M
D000818:Animals; D006801:Humans; D007156:Immunologic Memory; D007223:Infant; D007231:Infant, Newborn; D007279:Injections, Subcutaneous; D008253:Macaca mulatta; D008458:Measles Vaccine / Q000008:administration & dosage / Q000276:immunology*; D009500:Neutralization Tests; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology*; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology*
D008458:Measles Vaccine; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA