[Effect of substance P, neurokinin A and a selective agonist of tachykinin receptors of the NK-2 type on bile metabolism].
Based on the experiments on rats, changes of the level of bile secretion and chemical composition of bile following application of substance P, neurokinin A, and selective agonist of the NK-2 tachykinins receptors neurokinin A Fragment (4-10), are interpreted. These results demonstrate that tachykinins (SP, NKA, and NKA Fragment (4-10)) are true holeretics and affect various enzyme systems in the hepatocyte. The alterations of the coefficients of bile confirm that.
Spivak
L S
LS
Kiev National University, 01033 Kiev, 64 Volodimirska St., Ukraine.
Liashchenko
T P
TP
Vesel'skiĭ
S P
SP
Makarchuk
N E
NE
D000818:Animals; D001646:Bile / Q000737:chemistry / Q000378:metabolism; D022781:Hepatocytes / Q000187:drug effects / Q000201:enzymology; D008297:Male; D015288:Neurokinin A / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018041:Receptors, Neurokinin-2 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018039:Receptors, Tachykinin / Q000819:agonists* / Q000378:metabolism; D013373:Substance P / Q000494:pharmacology*; D015320:Tachykinins / Q000494:pharmacology*
D018041:Receptors, Neurokinin-2; D018039:Receptors, Tachykinin; D015320:Tachykinins; D013373:Substance P; D015288:Neurokinin A