title: Obesity wars: molecular progress confronts an expanding epidemic.
abstract: The worldwide prevalence of obesity is increasing at an alarming rate, with major adverse consequences for human health. This "obesity epidemic" is paralleled by a rapid and substantive increase in our understanding of molecular pathways and physiologic systems underlying the regulation of energy balance. While efforts to address the environmental factors that are responsible for the recent "epidemic" must continue, new molecular and physiologic insights into this system offer exciting possibilities for future development of successful therapies.
authors.affiliation: Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. jflier@bidmc.harvard.edu
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Flier
mesh_terms: D000818:Animals; D001835:Body Weight; D001921:Brain / Q000378:metabolism / Q000502:physiology; D004064:Digestive System; D004196:Disease Outbreaks; D004734:Energy Metabolism; D006801:Humans; D007028:Hypothalamic Hormones / Q000502:physiology; D020738:Leptin / Q000502:physiology; D008543:Melanins / Q000502:physiology; D008954:Models, Biological; D009765:Obesity / Q000453:epidemiology* / Q000235:genetics*; D010907:Pituitary Hormones / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D054411:Receptors, Leptin
chemical_list: D007028:Hypothalamic Hormones; D020738:Leptin; D008543:Melanins; D010907:Pituitary Hormones; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; C019463:melanin-concentrating hormone