title: Multiple cerebral microbleeds: MRI marker of a diffuse hemorrhage-prone state.
abstract: BACKGROUND
  Recent reports have indicated that cerebral microbleeds (CMBs) detected on gradient-echo (GRF) magnetic resonance imaging may be a risk factor for therapy related intracranial hemorrhages (ICHs).
  
  
  METHODS
  The authors describe 3 patients with multiple CMBs in whom ICHs occurred either after tissue plasminogen activator administration or after the initiation of antiplatelet therapy. Hemorrhages occurred in brain areas with normal appearances on GRE imaging and remote from the CMBs.
  
  
  CONCLUSIONS
  Multiple CMBs may signal a diffuse hemorrhage-prone vasculopathy.
authors.affiliation: National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Room B1D733, MSC 1063, Bethesda, MD 20892-1063, USA. chalelaj@ninds.nih.gov
authors.forename: Julio A
authors.initials: JA
authors.lastname: Chalela
authors.forename: Dong-Wha
authors.initials: DW
authors.lastname: Kang
authors.forename: Steven
authors.initials: S
authors.lastname: Warach
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000175:diagnosis; D005260:Female; D006801:Humans; D020300:Intracranial Hemorrhages / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D016684:Prone Position