title: Novel and efficient synthesis of difficult sequence-containing peptides through O-N intramolecular acyl migration reaction of O-acyl isopeptides.
abstract: A novel and efficient method for the synthesis of difficult sequence-containing peptides has been developed based on the synthesis of O-acyl isopeptides followed by an O-N intramolecular acyl migration reaction, resulting in a remarkable improvement of the yields.
authors.affiliation: Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmaceutical University, Yamashina-Ku, Kyoto 607-8412, Japan.
authors.forename: Youhei
authors.initials: Y
authors.lastname: Sohma
authors.forename: Masato
authors.initials: M
authors.lastname: Sasaki
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Tooru
authors.initials: T
authors.lastname: Kimura
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kiso
mesh_terms: D000215:Acylation; D007202:Indicators and Reagents; D010455:Peptides / Q000138:chemical synthesis*
chemical_list: D007202:Indicators and Reagents; D010455:Peptides