Covalent and noncovalent modification of thin filament action: the essential role of troponin in cardiac muscle regulation.
Troponin is essential for the regulation of cardiac contraction. Troponin is a sarcomeric molecular switch, directly regulating the contractile event in concert with intracellular calcium signals. Troponin isoform switching, missense mutations, proteolytic cleavage, and posttranslational modifications are known to directly affect sarcomeric regulation. This review focuses on physiologically relevant covalent and noncovalent modifications in troponin as part of a thematic series on cardiac thin filament function in health and disease.
Metzger
Joseph M
JM
Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Mich 48109, USA. metzgerj@umich.edu
Westfall
Margaret V
MV
D008841:Actin Cytoskeleton / Q000737:chemistry / Q000502:physiology; D000818:Animals; D030801:Animals, Genetically Modified; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D046911:Macromolecular Substances; D008958:Models, Molecular; D009200:Myocardial Contraction / Q000502:physiology*; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D010766:Phosphorylation; D020033:Protein Isoforms / Q000737:chemistry / Q000502:physiology; D011493:Protein Kinase C / Q000502:physiology; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D012518:Sarcomeres / Q000502:physiology; D014335:Tropomyosin / Q000737:chemistry / Q000502:physiology; D014336:Troponin / Q000737:chemistry / Q000502:physiology*
D046911:Macromolecular Substances; D020033:Protein Isoforms; D011943:Receptors, Adrenergic, beta; D014335:Tropomyosin; D014336:Troponin; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C; D007545:Isoproterenol