title: [Study of platelet membrane glycoprotein expression in mice with decompression sickness].
abstract: OBJECTIVE
  To investigate the role of expression of platelet membrane glycoprotein CD31, CD61 and CD62p in the pathogenesis of decompression sickness.
  
  
  METHODS
  Mice were randomly divided into decompression sickness group and normal control group. The animals in decompression sickness group were exposed to 600 kPa compressed air for 60 minute, then they were rapidly decompressed to normal pressure in one minute. At 60th minute after reducing to normal pressure, the expression of CD31, CD61 and CD62p on platelet membrane in mice was measured by flow cytometry.
  
  
  RESULTS
  The mean fluorescence intensity of CD31, CD61 and positive percentage of CD62p on platelet membrane [(18.64 +/- 1.01), (271.06 +/- 24.25), (4.48% +/- 0.43%) respectively] in decompression sickness group were significantly increased compared with normal control group [(16.89 +/- 1.69), (234.09 +/- 15.96), (3.00% +/- 0.66%) respectively] (P < 0.05, P < 0.01).
  
  
  CONCLUSIONS
  Inadequately rapid decompression may induce up regulation of platelet membrane glycoprotein CD31, CD61 and CD62p expression in mice, which may lead to thrombosis.
authors.affiliation: Department of Hyperbaric Oxygen, Beijing Chaoyang Hospital, Capital University of Medical Sciences, Beijing 100020, China.
authors.forename: Guo-zhong
authors.initials: GZ
authors.lastname: Wang
authors.forename: Chun-jin
authors.initials: CJ
authors.lastname: Gao
authors.forename: Huan
authors.initials: H
authors.lastname: Ge
authors.forename: Cheng-qing
authors.initials: CQ
authors.lastname: Xia
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000737:chemistry*; D003665:Decompression Sickness / Q000097:blood*; D005260:Female; D039661:Integrin beta3 / Q000097:blood*; D051379:Mice; D019007:P-Selectin / Q000097:blood*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D039661:Integrin beta3; D019007:P-Selectin; D019408:Platelet Endothelial Cell Adhesion Molecule-1