Human papillomavirus, p53 and cyclin D1 expression in oropharyngeal carcinoma.
Forty-two specimens from oropharyngeal (tonsil and base of tongue) squamous cell carcinoma patients (SCC) were studied for presence of HPV 16 by in situ hybridization and by immunohistochemistry for p53 and Cyclin D1 protein overexpression. Thirty-one per cent of cases were HPV-16 positive, which correlates with the prevalence reported worldwide. 74% of cases showed p53 protein overexpression and 79% showed Cyclin D1 overexpression. There was no correlation between HPV status and either p53 or Cyclin D1 overexpression (P>0.05). These three variables also did not correlate with factors such as grade of the tumour, stage of the disease or lymph nodal metastasis at presentation.
Kumar
R V
RV
Department of Pathology, Kidwai Memorial Institute of Oncology, India. kvijaykumar@vsnl.com
Kadkol
S S
SS
Daniel
R
R
Shenoy
A M
AM
Shah
K V
KV
D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000821:virology*; D019938:Cyclin D1 / Q000378:metabolism*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009856:Oncogene Proteins, Viral / Q000378:metabolism*; D009959:Oropharyngeal Neoplasms / Q000378:metabolism* / Q000821:virology*; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D014062:Tongue Neoplasms / Q000378:metabolism / Q000821:virology; D014067:Tonsillar Neoplasms / Q000378:metabolism / Q000821:virology; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D009856:Oncogene Proteins, Viral; D016159:Tumor Suppressor Protein p53; D019938:Cyclin D1