Haplotype and cancer risk analysis of two common mutations, BRCA1 4184del4 and BRCA2 2157delG, in high risk northwest England breast/ovarian families.
Evans
D G R
DG
Academic Unit of Medical Genetics, Regional Genetics Service and National Genetics Reference Laboratory, St Mary's Hospital, Manchester M13 0JH, UK. gareth.evans@cmmc.nhs.uk
Neuhausen
S L
SL
Bulman
M
M
Young
K
K
Gokhale
D
D
Lalloo
F
F
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019313:BRCA1 Protein / Q000235:genetics; D024682:BRCA2 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics*; D018567:Breast Neoplasms, Male / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D004739:England / Q000453:epidemiology; D005260:Female; D018703:Founder Effect; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics*; D010375:Pedigree; D018570:Risk Assessment; D017384:Sequence Deletion / Q000235:genetics*
D019313:BRCA1 Protein; D024682:BRCA2 Protein; D004273:DNA, Neoplasm