Increased leptin and white adipose tissue hypoplasia are sexually dimorphic in Lif null/Igf-I haploinsufficient mice.
We previously showed cooperation of leukemia inhibitory factor (LIF) and insulin-like growth factor I (IGF-I) during development. Mice doubly deficient in LIF and IGF-I died at birth. We now analyze the possible combined influence of both factors on postnatal growth. The haploinsufficiency of the Igf-I gene on a Lif null background caused a marked reduction in body mass index and white adipose tissue only in female mice. These animals had increased leptin, increased serum IGF-I and apparent substitution of white adipose tissue by brown adipose tissue. The complex interrelationships between LIF and IGF-I in regulating weight thus involve sexually dimorphic effects on adipose tissue differentiation and circulating leptin.
Fernández-Moreno
Carmen
C
Group of Growth Factors in Vertebrate Development, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Cienti;ficas (CSIC), Ramiro de Maetzu 9, 28040 Madrid, Spain.
Pichel
Jose G
JG
Chesnokova
Vera
V
De Pablo
Flora
F
D000273:Adipose Tissue / Q000473:pathology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D007334:Insulin-Like Growth Factor I / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D015850:Interleukin-6; D020738:Leptin / Q000378:metabolism*; D053605:Leukemia Inhibitory Factor; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D018832:Molecular Chaperones / Q000235:genetics / Q000378:metabolism*; D011506:Proteins; D012727:Sex Characteristics; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D015850:Interleukin-6; D020738:Leptin; D053605:Leukemia Inhibitory Factor; C507838:Lif protein, mouse; D018832:Molecular Chaperones; D011506:Proteins; D014280:Triglycerides; D007334:Insulin-Like Growth Factor I