[Effect of oral intake of an enteric capsule preparation containing Bifidobacterium longum on the progression of chronic renal failure].
Since the accumulation of intestinal putrefactive products, such as indole and phenol, is known to play a role in the exacerbation of chronic renal failure, reduction of these intestinal putrefactive products can be expected to retard the progression of renal failure. In the present study, an enteric capsule preparation containing Bifidobacterium longum(Bifidus HD) was administered orally to 27 patients with chronic renal failure(CRF) for 6 months. Though no significant effect was found in the whole group, a significant retardation of the progression of renal failure was found in patients with an initial serum creatinine level > or = 4.0 mg/dl or those with an initial serum inorganic phosphate level > or = 4.0 mg/dl. There was no adverse effect observed in any case. Bifidus HD is considered a useful tool for suppressing the progression of chronic renal failure(CRF) in the conservative period.
Ando
Yasuhiro
Y
Division of Nephrology, Department of Internal Medicine, Jichi Medical School, Tochigi, Japan.
Miyata
Yukio
Y
Tanba
Kaichiro
K
Saito
Osamu
O
Muto
Shigeaki
S
Kurosu
Megumi
M
Homma
Sumiko
S
Kusano
Eiji
E
Asano
Yasushi
Y
D000284:Administration, Oral; D000368:Aged; D001644:Bifidobacterium; D002214:Capsules; D005260:Female; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged
D002214:Capsules