In vitro study of some medicinally important Mannich bases derived from antitubercular agent.
Biologically active Mannich bases with heteroaromatic ring system have been synthesised employing Mannich reaction of isonicotinyl hydrazide with various sulphonamides/secondary amines. They were analysed by elemental analysis and characterized by uv, ir, 1H nmr spectroscopic studies. The Mannich bases were screened for their antibacterial activity against various gram positive and gram negative bacteria and were analyzed statistically. The results have shown that the compounds are quiet active against pathogens under study and were nontoxic.
Joshi
Sheela
S
School of Chemical Sciences, Devi Ahilya Vishwavidyalaya, Takshila campus, Khandwa road, Indore, India. spjoshi11@rediffmail.com
Khosla
Navita
N
Tiwari
Prapti
P
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D007928:Lethal Dose 50; D008352:Mannich Bases / Q000138:chemical synthesis* / Q000737:chemistry; D008745:Methylation; D015394:Molecular Structure; D013057:Spectrum Analysis
D000588:Amines; D000995:Antitubercular Agents; D008352:Mannich Bases