Prion deposition in olfactory biopsy of sporadic Creutzfeldt-Jakob disease.
Currently, definite peripheral markers for the in vivo diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) are not available. Here, we report the presence of pathological prion protein in the olfactory mucosa of a case with sporadic Creutzfeldt-Jakob disease. Prion protein immunoreactivity was detected in an olfactory biopsy performed 45 days after the disease onset, suggesting that the involvement of olfactory epithelium is an early event in sporadic Creutzfeldt-Jakob disease.
Tabaton
Massimo
M
Department of Neurosciences, University of Genoa, Genoa, Italy. mtabaton@neurologia.unige.it
Monaco
Salvatore
S
Cordone
Maria Paola
MP
Colucci
Monica
M
Giaccone
Giorgio
G
Tagliavini
Fabrizio
F
Zanusso
Gianluigi
G
D001706:Biopsy; D001923:Brain Chemistry; D007562:Creutzfeldt-Jakob Syndrome / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009831:Olfactory Mucosa / Q000378:metabolism* / Q000473:pathology; D018620:PrPSc Proteins / Q000378:metabolism*
D018620:PrPSc Proteins