title: Momordica charantia extracts inhibit uptake of monosaccharide and amino acid across rat everted gut sacs in-vitro.
abstract: The inhibitory effects of Momordica charantia extracts were studied on the uptake of glucose and tyrosine across rat everted gut sacs in vitro. The aqueous extract of the plant was found to inhibit primarily the uptake of glucose in a dose-dependent manner. Uptake of tyrosine was affected at high substrate concentrations only. The extract was also found to decrease the absorptive capacity of fluid across the small intestine and sodium ions. It is hypothesized that the effects of Momordica could involve a washout of glucose from the blood stream.
authors.affiliation: Department of Health and Medical Sciences, Faculty of Science, University of Mauritius, Reduit, Mauritius.
authors.forename: Mohamad Fawzi
authors.initials: MF
authors.lastname: Mahomoodally
authors.forename: Ameenah-Gurib
authors.initials: AG
authors.lastname: Fakim
authors.forename: Anwar Hussein
authors.initials: AH
authors.lastname: Subratty
mesh_terms: D000596:Amino Acids / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000737:chemistry; D005947:Glucose / Q000037:antagonists & inhibitors / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D029777:Momordica charantia / Q000737:chemistry*; D009005:Monosaccharides / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000037:antagonists & inhibitors / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism; D014867:Water
chemical_list: D000596:Amino Acids; D007004:Hypoglycemic Agents; D009005:Monosaccharides; D010936:Plant Extracts; D014867:Water; D014443:Tyrosine; D012964:Sodium; D005947:Glucose; D011188:Potassium