title: Inversely planned intensity modulated radiotherapy of the breast including the internal mammary chain: a plan comparison study.
abstract: The aim of this paper is to evaluate the benefit of inversely planned intensity modulated radiotherapy (IMRT) in the adjuvant irradiation of breast cancer when internal mammary lymph nodes are included in the treatment volume. 20 patients treated with 3D-planned conventional radiotherapy (CRT) following breast conserving surgery were included in the study. We chose 10 patients with left-sided and 10 patients with right-sided tumors. All treatment volumes included the internal mammary chain. For plan comparison to the applied CRT plan an inverse IMRT-plan in, step-and-shoot'-technique was calculated. For all patients IMRT resulted in an improved conformity of dose distribution to the target volume compared to CRT (mean COIN95: 0.798 vs. 0.514 with COIN95 = C1 * C2 (C1= fraction of CTV that is covered by > 95% of the prescribed dose and C2 = volume of CTV that is covered by > 95% of the prescribed dose/total volume that is covered by > 95% of the prescribed dose). In all cases with matching adjacent beams, the homogeneity in the target volume was improved. The volume of the ipsilateral lung irradiated with a dose higher than 20 Gy was reduced with IMRT from 24.6% to 13.1% compared to CRT. For left-sided target volume the heart volume with a dose higher than 30 Gy was reduced from 6.2% to 0.2%. The presented plan comparison study for irradiation of the breast and the parasternal lymph nodes showed a substantial improvement of the dose distribution by inversely planned IMRT compared to CRT. This is visible for the target volume, the ipsilateral lung and, in case of left-sided target volume, the heart. Despite an increase in integral dose to the entire normal tissue, the application of IMRT might be clinically advantageous in cases where no satisfying dose distribution can be obtained by CRT.
authors.affiliation: Klinische Kooperationseinheit des Deutschen Krebsforschungszentrums, INF 280, 69120 Heidelberg, Germany. c.thilmann@dkfz.de
authors.forename: Christoph
authors.initials: C
authors.lastname: Thilmann
authors.forename: Gabriele
authors.initials: G
authors.lastname: Sroka-Perez
authors.forename: Robert
authors.initials: R
authors.lastname: Krempien
authors.forename: Angelika
authors.initials: A
authors.lastname: Hoess
authors.forename: Michael
authors.initials: M
authors.lastname: Wannenmacher
authors.forename: Jürgen
authors.initials: J
authors.lastname: Debus
mesh_terms: D001943:Breast Neoplasms / Q000532:radiotherapy*; D004307:Dose-Response Relationship, Radiation; D006321:Heart / Q000528:radiation effects; D006801:Humans; D021621:Imaging, Three-Dimensional; D008168:Lung / Q000528:radiation effects; D008198:Lymph Nodes / Q000473:pathology / Q000528:radiation effects; D042361:Mammary Glands, Human / Q000473:pathology / Q000528:radiation effects; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis