title: Vasodilating properties of the stem bark extract of Mitragyna ciliata in rats and guinea pigs.
abstract: Mitragyna ciliata is commonly used in traditional medicine for the treatment of inflammation, hypertension, headache, rheumatism, gonorrhoea and broncho-pulmonary diseases. In the present study, the vascular relaxant effect in the rat and guinea-pig was investigated. The extract induced aortic relaxation in a concentration-dependent manner, with an EC(50) of 1.3 and 7 microg/mL for the noradrenaline- and KCl-induced contractions, respectively. The relaxant effect of the extract on KCl-induced contractions was fi ve times greater than on noradrenaline-induced contractions. Moreover, the relaxant effect of the extract was higher in rat aortic rings with endothelium (104.67%) than without endothelium (49.44%). Chemical analysis of the extract showed the presence of alkaloids and flavonoids which may be responsible for the antihypertensive properties.
authors.affiliation: Faculty of Science, University of Douala, PO Box 24157, Douala, Cameroon.
authors.forename: A
authors.initials: A
authors.lastname: Dongmo
authors.forename: M A
authors.initials: MA
authors.lastname: Kamanyi
authors.forename: P V
authors.initials: PV
authors.lastname: Tan
authors.forename: M
authors.initials: M
authors.lastname: Bopelet
authors.forename: W
authors.initials: W
authors.lastname: Vierling
authors.forename: H
authors.initials: H
authors.lastname: Wagner
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects; D006168:Guinea Pigs; D032065:Mitragyna; D009638:Norepinephrine; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011189:Potassium Chloride; D051381:Rats; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D010936:Plant Extracts; D014665:Vasodilator Agents; D011189:Potassium Chloride; D009638:Norepinephrine