Reproduction and survival in Mediterranean fruit flies: a "protein and energy" free radical model of aging.
We propose a "protein and energy" free radical model of aging that predicts patterns of survival and fertility curves for Mediterranean fruit flies. Mathematical and simulation models of individual physiological processes were constructed in terms of stochastic differential equations. The free radical theory of aging was used as a basis for construction of the model and was extended to describe the dynamics of the protein and energy balance in the functioning organism, including the concept of a maximum capacity for energy production. We fit the model to observed patterns of survival and fertility in flies given the basic diet schemes used in respective experiments. Age patterns of fertility and survival were predicted under various diet scenarios using the model, revealing that the predictions of the model are in good agreement with experimental data.
Butov
Alexander A
AA
Department of Applied Mathematics, Faculty of Mechanics and Mathematics, Ulyanovsk State University, Leo Tolstoi 42, 432700 Ulyanovsk, Russian Federation.
Carey
James R
JR
Volkov
Maxim A
MA
Sehl
Mary E
ME
Yashin
Anatoli I
AI
D000375:Aging / Q000502:physiology*; D000818:Animals; D033622:Ceratitis capitata / Q000502:physiology*; D004032:Diet; D004734:Energy Metabolism; D005260:Female; D005298:Fertility / Q000502:physiology; D005609:Free Radicals / Q000378:metabolism*; D008017:Life Expectancy; D008962:Models, Theoretical; D011506:Proteins / Q000378:metabolism*; D012098:Reproduction / Q000502:physiology*; D013269:Stochastic Processes; D013534:Survival
D005609:Free Radicals; D011506:Proteins