[Feasibility study of semi-solid matrices of theophylline-containing polyethyleneglycols].
Pharmaceutical manufacturing of semisolid matrices a past meeting two requirements: sufficient fluidity and sufficient viscosity. Ideally, the paste should have strong viscosity associated with a high dissolution rate. We studied the correlation between the viscosity and dissolution rate of polyethylene glycol (PEG) semisolid matrices (SSM) enclosing theophylline as a tracer. Nine formulations containing PEG of different molecular masses were studied. This work revealed the singularity of PEG binary mixtures. For pharmaceutical manufacturing, the conclusion of this work is that PEG binary mixtures enable circumventing the generally verified constraint: strong viscosity involves low dissolution ability.
Ortigosa
C A
CA
Laboratoire de Pharmacie Galénique, Pharmacotechnie et Biopharmacie, Faculté de Pharmacie, 15, avenue Charles Flahault, BP 14491, F34093 Montpellier Cedex 5.
Lasserre
Y J
YJ
D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000737:chemistry*; D004339:Drug Compounding; D004345:Drug Industry; D005079:Excipients; D005240:Feasibility Studies; D008970:Molecular Weight; D011092:Polyethylene Glycols; D012212:Rheology; D012995:Solubility; D013806:Theophylline / Q000008:administration & dosage / Q000737:chemistry*; D014783:Viscosity
D001993:Bronchodilator Agents; D005079:Excipients; D011092:Polyethylene Glycols; D013806:Theophylline