In vitro activity of BAL9141 against clinical isolates of gram-negative bacteria.
The minimum inhibitory concentration and minimum bactericidal concentration of BAL9141 against 150 clinical isolates of gram-negative bacteria were determined and compared to those of cefepime and ceftriaxone. BAL9141 exhibited comparable activity to cefepime and ceftriaxone against Haemophilus influenzae, Klebsiella pneumoniae, and extended-spectrum beta-lactamase nonproducing Enterobacter cloacae, and comparable activity to cefepime against Pseudomonas aeruginosa.
Issa
Nicolas C
NC
Department of Internal Medicine, Rochester, MN, USA.
Rouse
Mark S
MS
Piper
Kerryl E
KE
Wilson
Walter R
WR
Steckelberg
James M
JM
Patel
Robin
R
D002511:Cephalosporins / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006090:Gram-Negative Bacteria / Q000145:classification / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D012494:Sampling Studies; D012680:Sensitivity and Specificity
D002511:Cephalosporins; C443755:ceftobiprole