title: Electrospun P(LLA-CL) nanofiber: a biomimetic extracellular matrix for smooth muscle cell and endothelial cell proliferation.
abstract: Poly(L-lactide-co-epsilon-caprolactone) [P(LLA-CL)] with L-lactide to epsilon-caprolactone ratio of 75 to 25 has been electrospun into nanofibers. The relationship between electrospinning parameters and fiber diameter has been investigated. The fiber diameter decreased with decreasing polymer concentration and with increasing electrospinning voltage. The X-ray diffractometer and differential scanning colorimeter results suggested that the electrospun nanofibers developed highly oriented structure in CL-unit sequences during the electrospinning process. The biocompatibility of the nanofiber scaffold has been investigated by culturing cells on the nanofiber scaffold. Both smooth muscle cell and endothelial cell adhered and proliferated well on the P(LLA-CL) nanofiber scaffolds.
authors.affiliation: Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, 117576, Singapore, Singapore.
authors.forename: X M
authors.initials: XM
authors.lastname: Mo
authors.forename: C Y
authors.initials: CY
authors.lastname: Xu
authors.forename: M
authors.initials: M
authors.lastname: Kotaki
authors.forename: S
authors.initials: S
authors.lastname: Ramakrishna
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry*; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry*; D018929:Cell Culture Techniques / Q000379:methods; D002455:Cell Division / Q000502:physiology; D048429:Cell Size; D002478:Cells, Cultured; D004563:Electrochemistry; D042783:Endothelial Cells / Q000166:cytology* / Q000502:physiology; D005109:Extracellular Matrix; D032389:Myocytes, Smooth Muscle / Q000166:cytology* / Q000502:physiology; D036103:Nanotechnology / Q000379:methods; D043942:Nanotubes / Q000737:chemistry / Q000648:ultrastructure; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry*; D012399:Rotation; D013784:Textiles; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C062968:lactide-caprolactone copolymer