title: The role of MAP kinases in trauma and ischemia-reperfusion.
abstract: Mitogen-activated protein kinases (MAPKs) have been the focus of a number of studies, as these compounds are involved in a number of important inflammatory cell signaling mechanisms. Recent studies have further elucidated the role of MAPKs in the inflammatory response, as a result of trauma and/or ischemia-reperfusion (I/R) injury. There are three major classes of MAPKs that may be involved in the inflammatory response: extracellular signal-regulated kinases (ERKs), stress-activated protein kinases (SAPKs)/c-Jun NH(2)-terminal kinases (JNKs), and p38 MAPKs (p38). This is clinically relevant, because these pathways may be a possible target for anti-inflammatory drug intervention. This review studies the role of MAPKs in trauma and/or I/R.
authors.affiliation: Michigan State University/Kalamazoo Center for Medical Studies, Kalamazoo, Michigan, USA.
authors.forename: Edwin W
authors.initials: EW
authors.lastname: Lai
authors.forename: Luis H
authors.initials: LH
authors.lastname: Toledo-Pereyra
authors.forename: Jon
authors.initials: J
authors.lastname: Walsh
authors.forename: F
authors.initials: F
authors.lastname: Lopez-Neblina
authors.forename: R
authors.initials: R
authors.lastname: Anaya-Prado
mesh_terms: D000818:Animals; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D015427:Reperfusion Injury / Q000378:metabolism*; D014947:Wounds and Injuries / Q000378:metabolism*
chemical_list: D020928:Mitogen-Activated Protein Kinases