[The effect of overtraining on human sperm chromatin structure].
OBJECTIVE
To identify the effects of overtraining on human sperm DNA.


METHODS
Molecular epidemiological investigation of 249 men from different groups (training and non-training) was carried out by using flow cytometer to detect the integrity and damage of in situ DNA of sperm nucleus, and sperm chromatin structure assay was performed.


RESULTS
The average COMPalpha(t) in training group was 11.02% while that in control group was 5.90% (P < 0.01). COMPalpha(t) was significantly correlated with sperm activity (r = 0.41, P < 0.05).


CONCLUSIONS
Overtraining could induce sperm DNA injury and affect sperm activity, thus to decrease the potentiality of reproduction.
Ding
Xiao-ping
XP
Department of Reproductive Center, The 202nd Hospital of PLA, Shenyang 110003, China.
Yan
Su-wen
SW
Zhang
Ning
N
Zhang
Li
L
Tang
Jie
J
Lu
Hai-ou
HO
D000328:Adult; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D053938:DNA Fragmentation; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D013081:Sperm Motility / Q000502:physiology; D013094:Spermatozoa / Q000166:cytology / Q000378:metabolism*
D002843:Chromatin