The idiopathic hypereosinophilic syndrome.
Idiopathic hypereosinophilic syndrome (IHES) is characterized by sustained (> 6 months) peripheral eosinophilia (> 1500 cells/mm3), organ damage, and exclusion of other causes. IHES is clinically and pathogenetically heterogenous, and several potential disease mechanisms have been described. The prognosis for patients with IHES has improved with targeted therapies and aggressive management of complications. We report a case of IHES and review the clinical features, evaluation, and options for treatment.
Lin
Debby A
DA
Harvard Medical School, Departments of Medicine and Pediatrics, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Boyce
Joshua A
JA
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004804:Eosinophils / Q000473:pathology; D005076:Exanthema / Q000473:pathology; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic
D000305:Adrenal Cortex Hormones