Primary malignant mixed mullerian tumor of the vagina immunohistochemically confirmed.
METHODS
We report the case of a 74-year old woman who presented with an ulcerated mass of the vagina. Histology of the tumor showed malignant mixed mullerian tumor (MMMT) with squamous and spindle cell stromal components, associated with high-grade vaginal intraepithelial neoplasia (VaIN 3). Immunohistochemical study of the neoplasm revealed that the malignant stromal tumor was a high-grade leiomyosarcoma. Despite the multimodal therapeutic approach, the patient died within 11 months.


CONCLUSIONS
The vagina is a rare site of presentation of primary MMMTs and the present case is the second one immunohistochemically confirmed.
Sotiropoulou
Maria
M
Department of Pathology, Alexandra Hospital, Vassilissis Sophies 80, 115 28 Athens, Greece.
Haidopoulos
Dimitrios
D
Vlachos
George
G
Pilalis
Athanasios
A
Rodolakis
Alexandros
A
Diakomanolis
Emmanuel
E
D000368:Aged; D000855:Anorexia; D001706:Biopsy; D002584:Cervix Uteri / Q000601:surgery; D003475:Curettage; D017809:Fatal Outcome; D005221:Fatigue; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D008279:Magnetic Resonance Imaging; D018200:Mixed Tumor, Mullerian / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014625:Vaginal Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy