[Neuroprotective effect of cytoflavin in closed craniocerebral trauma].
The efficacy of a complex preparation cytoflavin was studied on rats with a model of closed craniocerebral trauma. Cytoflavin produced normalization of the energy exchange, lipid peroxidation, and antioxidant system functioning in nervous tissues. The treatment significantly reduced the degree of posttraumatic edemation in the brain. The cerebroprotective action of cytoflavin was somewhat superior to the effect of the reference drug solcoseryl.
Bul'on
V V
VV
Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, ul. akademika Pavlova 12, St. Petersburg, 197376 Russia.
Zarubina
I V
IV
Kovalenko
A L
AL
Alekseeva
L E
LE
Sapronov
N S
NS
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001929:Brain Edema / Q000209:etiology / Q000517:prevention & control; D006259:Craniocerebral Trauma / Q000150:complications / Q000378:metabolism / Q000517:prevention & control*; D004338:Drug Combinations; D004734:Energy Metabolism / Q000187:drug effects; D005486:Flavin Mononucleotide / Q000627:therapeutic use*; D007290:Inosine Diphosphate / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009536:Niacinamide / Q000627:therapeutic use*; D051381:Rats; D019802:Succinic Acid / Q000627:therapeutic use*
D000975:Antioxidants; D004338:Drug Combinations; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate; D019802:Succinic Acid