Achieving antigen-specific immune regulation.
A study in this issue of the JCI shows that in response to autoantigens consisting of peptides from normal proteins, patients with diabetes mount a T cell response characterized by production of IFN-gamma (see the related article beginning on page 451). However, in response to these same antigens, T cells from normal control subjects produce IL-10. The antigen-specific response characterized by release of a regulatory cytokine suggests a mechanism for the control of autoimmunity that is initiated at the time of antigen presentation.
Herold
Kevan C
KC
Naomi Berrie Diabetes Center, Division of Endocrinology and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA. kh318@columbia.edu
D000941:Antigens / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000276:immunology*; D016753:Interleukin-10 / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism
D000941:Antigens; D016753:Interleukin-10