title: An injectable calcium sulfate-based bone graft putty using hydroxypropylmethylcellulose as the plasticizer.
abstract: The addition of a plasticizer to synthetic bone graft substitutes can improve handling characteristics, injectability, and the ability to uniformly fill defects. Restoration of large medullary bone defects using an injectable calcium sulfate-based putty using hydroxypropylmethylcellose as the plasticizer was compared to conventional calcium sulfate paste in a canine model. Beginning 2 weeks following implantation, serial clinical and specimen radiographs demonstrated a similar progressive resorption of the implanted materials and replacement with new bone for both the putty and paste forms of calcium sulfate. The area fraction of new bone and remaining implant material in bone defects treated with the putty were not significantly different from defects treated with conventional calcium sulfate paste after 13 and 26 weeks. In addition to its handling characteristics, the putty was biocompatible and as effective as conventional calcium sulfate paste in achieving substantial bony restoration of a large, critical-size bone defect.
authors.affiliation: Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Ill, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Urban
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Turner
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Hall
authors.forename: Susan I
authors.initials: SI
authors.lastname: Infanger
authors.forename: Naveed
authors.initials: N
authors.lastname: Cheema
authors.forename: Tae-Hong
authors.initials: TH
authors.lastname: Lim
authors.forename: Kelly
authors.initials: K
authors.lastname: Richelsoph
mesh_terms: D000818:Animals; D018786:Bone Substitutes; D002133:Calcium Sulfate / Q000008:administration & dosage; D004285:Dogs; D065347:Hypromellose Derivatives; D015552:Injections, Intralesional; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives; D010968:Plasticizers
chemical_list: D018786:Bone Substitutes; D010968:Plasticizers; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D002133:Calcium Sulfate