The effects of losartan and immobilization stress on heart rate variability and plasma corticosterone levels in rats.
In this study, the effects of losartan, an angiotensin II receptor antagonist, on heart rate variability and the changes of plasma corticosterone levels caused by immobilization stress were investigated. Losartan (3 mg/kg, p.o.) significantly prevented increases in plasma corticosterone levels in both losartan+acute stress and losartan+chronic stress groups. But, losartan did not prevent the diminution of the power of heart rate variability caused by stress. Our results supported the idea that the renin-angiotensin system is also involved in the stress- induced cardiovascular response, besides the autonomic nervous system. But, the effects of losartan on heart rate variability remained controversial.
Uresin
Ali Yagiz
AY
Istanbul University, Istanbul Faculty of Medicine, Department of Pharmacology and Clinical Pharmacology, Capa, Istanbul, Turkey.
Tonyali
Hüseyin
H
Karamürsel
Sacit
S
D000704:Analysis of Variance; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D003345:Corticosterone / Q000097:blood*; D004569:Electroencephalography / Q000379:methods; D006339:Heart Rate / Q000187:drug effects*; D007103:Immobilization; D019808:Losartan / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000097:blood / Q000503:physiopathology*; D013997:Time Factors
D000959:Antihypertensive Agents; D019808:Losartan; D003345:Corticosterone