Development of a quantitative structure-activity relationship model for inhibition of gram-positive bacterial cell growth by biarylamides.
A set of compounds consisting of a new and diverse collection of biarylamides was examined using quantitative structure-activity relationship techniques for the purpose of developing a model to describe inhibition of gram-positive bacterial growth (minimum inhibition concentration). The model was sought in order to obtain insight for designing new molecules. A detailed analysis of the underlying structure-activity relationship helped provide insight concerning which structural features of the molecules modulated the activity of the compounds against gram-positive organisms.
Stanton
David T
DT
Health Care Research Center, Procter & Gamble Pharmaceuticals, 8700 Mason-Montgomery Road, Mason, Ohio 45040-9462, USA. stanton.dt@pg.com
Madhav
Prakash J
PJ
Wilson
Larry J
LJ
Morris
Timothy W
TW
Hershberger
Paul M
PM
Parker
Christian N
CN
D000577:Amides / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D021281:Quantitative Structure-Activity Relationship
D000577:Amides