title: Metallation of pyridines and quinolines in the presence of a remote carboxylate group. New syntheses of heterocyclic quinones.
abstract: 2-(3- and 2-Pyridylcarbonyl)benzoic acids (2,3), 2-(2-pyridylcarbonyl)thiophene-3-carboxylic acid (6), 2-(3-quinolylcarbonyl)benzoic acid (10), and most of the corresponding esters (compounds 1,7 and 9 ) are readily synthesized and involved in a deprotonation-condensation sequence. Biologically active aza-anthraquinones such as benzo[g]isoquinoline-5,10-dione (2-azaanthraquinone, 4 ) and benzo[g]quinoline-5,10-dione (1-azaanthraquinone, 5) are prepared using the strategy. Extension to other heterocyclic quinones such as thieno[3,2-g]quinoline-4,9-dione (8) and benzo[j]phenanthridine-7,12-dione (11) is also investigated.
authors.affiliation: Laboratoire de Chimie Organique Fine et Hétérocyclique, IRCOF, UMR 6014, Place E. Blondel, BP 08, 76131 Mont-Saint-Aignan, France. florence.mongin@insa-rouen.fr
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Rebstock
authors.forename: Florence
authors.initials: F
authors.lastname: Mongin
authors.forename: François
authors.initials: F
authors.lastname: Trécourt
authors.forename: Guy
authors.initials: G
authors.lastname: Quéguiner