Oximidine III, a new antitumor antibiotic against transformed cells from Pseudomonas sp. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
Our screening for antitumor antibiotics against transformed cells resulted in the isolation of a new active metabolite, oximidine III, from Pseudomonas sp. QN05727. This substance selectively inhibited the growth of rat 3Y1 fibroblasts transformed with various oncogenes. In ras- or src-transformed cells, oximidine III arrested the cell cycle at G1 phase and increased the expression of p21WAF1.
Hayakawa
Yoichi
Y
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan. hayakawa@iam.u-tokyo.ac.jp
Tomikawa
Taijiro
T
Shin-ya
Kazuo
K
Arao
Nakako
N
Nagai
Koji
K
Suzuki
Ken-ichi
K
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002461:Cell Line, Transformed; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D005347:Fibroblasts / Q000187:drug effects; D005434:Flow Cytometry; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011549:Pseudomonas; D051381:Rats
D000903:Antibiotics, Antineoplastic; D004852:Epoxy Compounds; D007783:Lactones; C482071:oximidine III