title: New laboratory technique measures projected dynamic area of prosthetic heart valves.
abstract: OBJECTIVE
  Fluid dynamic forces, valve design factors and gravity interactively determine the complex motion of prosthetic heart valve occluders. Although motion has been investigated, in vitro, using high-speed image recording, the technique has significant cost and limitations on resolution.
  
  
  METHODS
  The kinematics of mechanical and biological valve occluders in the aortic and mitral positions were assessed by measuring projected dynamic valve area (PDVA). Valves were tested in a pulse duplicator system simulating normal cardiac conditions. To quantify PDVA, light passage through back-illuminated valves was measured by a calibrated photosensor with high-frequency response up to 150 kHz. Ten consecutive cycles were sampled using a PC data acquisition system. The system was calibrated under static conditions using reference areas.
  
  
  RESULTS
  Several characteristics can be obtained from PDVA measurement including: maximum and minimum PDVA; rate of change of valve opening and closing PDVA; occluder rebound; and oscillatory open occluder behavior. Biological valves open more rapidly, close more gently, and exhibit no occluder rebound. They are also unaffected by gravity, and vary little in behavior from cycle to cycle compared with mechanical valves.
  
  
  CONCLUSIONS
  A new method for measuring PDVA has been developed. Distinct differences in performance between valves were identified. It is hypothesized that, aside from patient factors and differences in materials, mechanical valves that mimic the PDVA behavior of biological valves, will lead to reduction of thrombogenicity, cavitation and high-intensity transient signals (HITS), and also reduce sound level and regurgitation.
authors.affiliation: ViVitro Systems Inc., Victoria, BC, Canada. vivitro@horizon.bc.ca
authors.forename: Lawrence N
authors.initials: LN
authors.lastname: Scotten
authors.forename: David K
authors.initials: DK
authors.lastname: Walker
mesh_terms: D003326:Coronary Circulation; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D008955:Models, Cardiovascular; D011474:Prosthesis Design