Elevated false recognition in patients with frontal lobe damage is neither a general nor a unitary phenomenon.
This study examined verbal recognition memory in amnesic patients with frontal lesions (AF), nonamnesic patients with frontal lesions (NAF), and amnesic patients with medial temporal lesions (MT). To examine susceptibility to false alarms, the number of studied words drawn from various categories was varied. The AF and MT groups demonstrated reduced hits and increased false alarms. False alarms were especially elevated when item-specific recollection was strongest in control participants. The NAF group performed indistinguishably from control participants, but several patients showed excessive false alarms in the context of normal hit rates. These patients exhibited impaired monitoring and verification processes. The findings demonstrate that elevated false recognition is not characteristic of all frontal patients and may result from more than 1 underlying mechanism.
Verfaellie
Mieke
M
Boston University School of Medicine, Memory Disorders Research Center, Boston Veterans Affairs Health Care System, Boston, MA, USA. verf@bu.edu
Rapcsak
Steven Z
SZ
Keane
Margaret M
MM
Alexander
Michael P
MP
D000368:Aged; D000647:Amnesia / Q000209:etiology* / Q000503:physiopathology*; D000704:Analysis of Variance; D001925:Brain Damage, Chronic / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D021641:Recognition, Psychology / Q000502:physiology*; D012720:Severity of Illness Index; D017603:Signal Detection, Psychological / Q000502:physiology; D013702:Temporal Lobe; D014705:Verbal Behavior; D014706:Verbal Learning / Q000502:physiology*