title: Laparoscopic Nissen fundoplication for treating reflux in lung transplant recipients.
abstract: Gastroesophageal reflux disease may contribute to pulmonary injury and the development of bronchiolitis obliterans syndrome in lung transplant patients. As a result, such individuals are increasingly likely to undergo corrective gastrointestinal surgery. The present study collected outcome data for 28 lung transplant patients with documented reflux who underwent an uncomplicated laparoscopic Nissen fundoplication at our institution. The results were compared to data from 63 nontransplant reflux patients who had undergone the procedure over the same time period. All Nissen fundoplications were conducted by the same surgeon. There were no intraoperative or perioperative deaths in either patient group. Operative parameters did not differ but the postoperative hospital stay was significantly greater for the lung transplant patients (P<0.05). Seven transplant patients (25%) were readmitted within 30 days compared to two readmissions (3.2%) in the reflux group. Five transplant patients (17.9%) have died, all from pulmonary complications; on average, death occurred 15.5 months after the Nissen surgery. There have been no deaths in the reflux group. These data indicate that laparoscopic Nissen fundoplication can be performed on lung transplant recipients to treat reflux. The average hospital stay is longer and there are more frequent readmissions in this population, but this does not appear to be due to any Nissen-related morbidity.
authors.affiliation: Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: Elizabeth K
authors.initials: EK
authors.lastname: O'Halloran
authors.forename: James D
authors.initials: JD
authors.lastname: Reynolds
authors.forename: Christine L
authors.initials: CL
authors.lastname: Lau
authors.forename: Roberto J
authors.initials: RJ
authors.lastname: Manson
authors.forename: R Duane
authors.initials: RD
authors.lastname: Davis
authors.forename: Scott M
authors.initials: SM
authors.lastname: Palmer
authors.forename: Theodore N
authors.initials: TN
authors.lastname: Pappas
authors.forename: Erik M
authors.initials: EM
authors.lastname: Clary
authors.forename: W Steve
authors.initials: WS
authors.lastname: Eubanks
mesh_terms: D000328:Adult; D015897:Comorbidity; D000075202:Contraindications; D005260:Female; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000453:epidemiology / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy; D007902:Length of Stay; D008171:Lung Diseases / Q000453:epidemiology; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D010359:Patient Readmission; D011183:Postoperative Complications / Q000601:surgery*; D012189:Retrospective Studies