title: Circadian periodicity of plasma lipid peroxides and other anti-oxidants as putative markers in gynecological malignancies.
abstract: BACKGROUND
  The chronome (from chronos, time, and nomos, rule), or time structure, of lipid peroxidation and anti-oxidant defense mechanisms may relate to prevention and curative chronochemotherapeutic efficacy and management.
  
  
  METHODS
  Newly diagnosed women with gynecological malignancies (N = 30), 30-60 years of age, and age-matched clinically healthy women (N = 35) provided blood samples every 6 hours for 24 hours under standardized conditions. Plasma malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) activities, and serum ascorbate, urate and high-density lipoprotein cholesterol (HDL-C) concentrations were determined.
  
  
  RESULTS
  Each variable underwent circadian variation (p < or = 0.002). Patients differed from controls by their overall chronome-adjusted mean value (MESOR) and by the circadian dynamics in the spectral element of their chronome.
  
  
  CONCLUSIONS
  Chronomes of putative anti- and pro-oxidants should be mapped to explore their putative chemotherapeutic role as markers in cancer chronoprevention and management of established disease.
authors.affiliation: Departments of Biochemistry, Obstetrics & Gynaecology and Surgery (Surgical Oncology Unit), King George's Medical College, Lucknow-226003, India.
authors.forename: Ranjana
authors.initials: R
authors.lastname: Singh
authors.forename: Rajesh K
authors.initials: RK
authors.lastname: Singh
authors.forename: A A
authors.initials: AA
authors.lastname: Mahdi
authors.forename: R K
authors.initials: RK
authors.lastname: Singh
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: A K
authors.initials: AK
authors.lastname: Tripathi
authors.forename: R
authors.initials: R
authors.lastname: Rai
authors.forename: Urmila
authors.initials: U
authors.lastname: Singh
authors.forename: G
authors.initials: G
authors.lastname: Cornélissen
authors.forename: O
authors.initials: O
authors.lastname: Schwartzkopff
authors.forename: F
authors.initials: F
authors.lastname: Halberg
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000097:blood*; D002940:Circadian Rhythm; D005260:Female; D005833:Genital Neoplasms, Female / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood*; D008875:Middle Aged
chemical_list: D000975:Antioxidants; D014408:Biomarkers, Tumor; D008054:Lipid Peroxides