title: Comparison of step-down and binary search algorithms for determination of defibrillation threshold in humans.
abstract: Determination of DFT is an integral part of ICD implantation. Two commonly used methods of DFT determination, the step-down method and the binary search method, were compared in 44 patients undergoing ICD testing for standard clinical indications. The step-down protocol used an initial shock of 18 J. The binary search method began with a shock energy of 9 J and successive shock energies were increased or decreased depending on the success of the previous shock. The DFT was defined as the lowest energy that successfully terminated ventricular fibrillation. The binary search method has the advantage of requiring a predetermined number of shocks, but some have questioned its accuracy. The study found that (mean) DFT obtained by the step-down method was 8.2 +/- 5.0, whereas by the binary search method DFT was 8.1 +/- 0.7 J, P = NS. DFT differed by no more than one step between methods in 32 (71%) of patients. The number of shocks required to determine DFT by the step-down method was 4.6 +/- 1.4, whereas by definition, the binary search method always required three shocks. In conclusion, the binary search method is preferable because it is of comparable efficacy and requires fewer shocks.
authors.affiliation: Division of Cardiology, Department of Medicine, the University of Maryland, the Department of Veterans Affairs Medical Center, Baltimore, Maryland 21201, USA. sshorofs@medicine.umaryland.edu
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Shorofsky
authors.forename: Robert W
authors.initials: RW
authors.lastname: Peters
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Rashba
authors.forename: Michael R
authors.initials: MR
authors.lastname: Gold
mesh_terms: D000368:Aged; D000465:Algorithms; D017147:Defibrillators, Implantable; D004554:Electric Countershock / Q000295:instrumentation / Q000379:methods*; D017097:Electric Impedance; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D011446:Prospective Studies; D014693:Ventricular Fibrillation / Q000628:therapy