In vitro interactions of licensed and novel antifungal drugs against Fusarium spp.
We have studied the in vitro interactions of amphotericin B (AMB) with terbinafine (TBF), itraconazole, voriconazole (VCZ), albaconazole, and ravuconazole (RVZ), as well as TBF combined with the same azoles, against 11 isolates of Fusarium spp. using the fractional inhibitory concentration index. The highest percentage of synergistic interactions was observed for the combinations AMB-RVZ, TBF-VCZ, and TBF-RCZ.
Ortoneda
Montserrat
M
Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Reus, Spain.
Capilla
Javier
J
Javier Pastor
F
F
Pujol
Isabel
I
Guarro
Josep
J
D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D004347:Drug Interactions; D025141:Drug Resistance, Fungal; D005670:Fusarium / Q000145:classification / Q000187:drug effects*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D011799:Quinazolines / Q000494:pharmacology; D012680:Sensitivity and Specificity; D000077291:Terbinafine; D013844:Thiazoles / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology; D065819:Voriconazole
D000935:Antifungal Agents; D009281:Naphthalenes; D011743:Pyrimidines; D011799:Quinazolines; D013844:Thiazoles; D014230:Triazoles; D017964:Itraconazole; D000666:Amphotericin B; C104066:ER 30346; D000077291:Terbinafine; D065819:Voriconazole; C112424:albaconazole