Central pattern generators deciphered by molecular genetics.
Central pattern generators (CPGs) are localized neuronal networks that have the ability to produce rhythmic movements even in the absence of movement-related sensory feedback. They are found in all animals, including man, and serve as informative model systems for understanding how neuronal networks produce behavior. Traditionally, CPGs have been investigated with electrophysiological techniques. Here we review recent molecular and genetic approaches for dissecting the organization and development of CPGs.
Kiehn
Ole
O
Mammalian Locomotor Laboratory, Department of Neuroscience, The Karolinska Institute, Retzius vag 8, 171 77 Stockholm, Sweden. ole.kiehn@neuro.ki.se
Kullander
Klas
K
D000818:Animals; D002490:Central Nervous System / Q000502:physiology*; D004330:Drosophila; D004594:Electrophysiology; D006801:Humans; D008959:Models, Neurological; D008967:Molecular Biology; D009068:Movement; D009415:Nerve Net / Q000502:physiology*