title: Clinical evaluation of the Er:YAG laser in combination with an enamel matrix protein derivative for the treatment of intrabony periodontal defects: a pilot study.
abstract: OBJECTIVE
  The aim of the present study was to compare the combination therapy of deep intrabony periodontal defects using an Er:YAG laser (ERL) and enamel matrix protein derivative (EMD) to scaling and root planing+ ethylenediaminetetraacetic acid (EDTA)+EMD.
  
  
  METHODS
  Twenty-two patients with chronic periodontitis, each of whom displayed 1 intrabony defect, were randomly treated with access flap surgery and defect debridement with an Er:YAG (160 mJ/pulse, 10 Hz) plus EMD (test) or with access flap surgery followed by scaling and root planing (SRP) with hand instruments plus EDTA and EMD (control). The following clinical parameters were recorded at baseline and at 6 months: plaque index, gingival index, bleeding on probing (BOP), probing depth (PD), gingival recession, and clinical attachment level (CAL). No differences in any of the investigated parameters were observed at baseline between the two groups.
  
  
  RESULTS
  Healing was uneventful in all patients. At 6 months after therapy, the sites treated with ERL and EMD showed a reduction in mean PD from 8.6 +/- 1.2 mm to 4.6 +/- 0.8 mm and a change in mean CAL from 10.7 +/- 1.3 mm to 7.5 +/- 1.4 mm (p < 0.001). In the group treated with SRP+EDTA+EMD, the mean PD was reduced from 8.1 +/- 0.8 mm to 4.0 +/- 0.5 mm and the mean CAL changed from 10.4 +/- 1.1 mm to 7.1 +/- 1.2 mm (p < 0.001). No statistically significant differences in any of the investigated parameters were observed between the test and control group.
  
  
  CONCLUSIONS
  Within the limits of the present study, it may be concluded that both therapies led to short-term improvements of the investigated clinical parameters, and the combination of ERL and EMD does not seem to improve the clinical outcome of the therapy additionally compared to SRP+EDTA+EMD.
authors.affiliation: Department of Oral Surgery, Heinrich Heine University, Düsseldorf, Germany. info@frank-schwarz.de
authors.forename: Frank
authors.initials: F
authors.lastname: Schwarz
authors.forename: Anton
authors.initials: A
authors.lastname: Sculean
authors.forename: Thomas
authors.initials: T
authors.lastname: Georg
authors.forename: Jürgen
authors.initials: J
authors.lastname: Becker
mesh_terms: D016301:Alveolar Bone Loss / Q000209:etiology / Q000628:therapy*; D018786:Bone Substitutes / Q000627:therapeutic use*; D002614:Chelating Agents / Q000627:therapeutic use; D002908:Chronic Disease; D003646:Debridement / Q000295:instrumentation; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D003774:Dental Plaque Index; D012534:Dental Scaling; D004492:Edetic Acid / Q000627:therapeutic use; D004871:Erbium; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D010513:Periodontal Ligament / Q000601:surgery; D010518:Periodontitis / Q000150:complications / Q000628:therapy*; D010865:Pilot Projects; D016745:Root Planing; D013524:Surgical Flaps; D016896:Treatment Outcome; D015019:Yttrium
chemical_list: D018786:Bone Substitutes; D002614:Chelating Agents; D003746:Dental Enamel Proteins; C109069:enamel matrix proteins; D015019:Yttrium; D004871:Erbium; D004492:Edetic Acid