Synergistic effects of anacardic acids and methicillin against methicillin resistant Staphylococcus aureus.
The synergistic effects of 6-alk(en)ylsalcylic acids, also known as anacardic acids, in combination with methicillin against Staphylococcus aureus ATCC 33591 (MRSA) was investigated. The double bond in C15-anacardic acids is not essential in eliciting the antibacterial activity but is associated with increasing the activity. The synergistic effects decreased with increasing the number of double bonds in the alkyl chain. On the other hand, the antibacterial activity of anacardic acids possessing different alkyl chain lengths against the same MRSA strain was found to be a parabolic function of their lipophilicity and maximized with the alkyl chain length of C10 and C12. Notably, the synergistic effects were noted to increase with increasing the alkyl chain length.
Muroi
Hisae
H
Department of Environmental Science, Policy and Management, University of California at Berkeley, CA 94720-3112, USA.
Nihei
Ken-ichi
K
Tsujimoto
Kazuo
K
Kubo
Isao
I
D048729:Anacardic Acids; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D004357:Drug Synergism; D008712:Methicillin / Q000494:pharmacology*; D016106:Methicillin Resistance; D015394:Molecular Structure; D012459:Salicylates / Q000737:chemistry / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
D048729:Anacardic Acids; D000900:Anti-Bacterial Agents; D012459:Salicylates; C088115:anacardic acid; D008712:Methicillin