title: Arterial oxygen fluctuation and retinopathy of prematurity in very-low-birth-weight infants.
abstract: OBJECTIVE
  To determine the influence of arterial oxygen fluctuation on development of threshold ROP.
  
  
  METHODS
  Retrospective study of 231 infants, < or =1500 g birth weight, who were admitted to Arkansas Children's Hospital NICU from January 1993 to June 1995. Fluctuation in partial pressure of dissolved arterial oxygen (PaO(2)) was expressed as coefficient of variation (CoV) for each infant. We investigated the relationship between CoV at three intervals and the risk of developing threshold ROP.
  
  
  RESULTS
  The odds ratio (OR) of developing threshold ROP versus prethreshold ROP or less associated with a 10% increase in the CoV during the first 5 days of oxygen therapy was 1.44, and during the first 10 days was 1.51. When analysis was restricted to infants receiving 30 days of therapy, the OR during the first 5 days of therapy was 1.67, during the first 10 days was 1.82, and during days 11-30 was 1.68.
  
  
  CONCLUSIONS
  Very-low-birth-weight infants experiencing fluctuating PaO(2) are at higher risk of threshold ROP.
authors.affiliation: Department of Neonatology, Vanderbilt University, Nashville, TN 37232, USA.
authors.forename: Jackie R
authors.initials: JR
authors.lastname: York
authors.forename: Susan
authors.initials: S
authors.lastname: Landers
authors.forename: Russell S
authors.initials: RS
authors.lastname: Kirby
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Arbogast
authors.forename: John S
authors.initials: JS
authors.lastname: Penn
mesh_terms: D005260:Female; D005865:Gestational Age; D006801:Humans; D000860:Hypoxia / Q000150:complications*; D007231:Infant, Newborn; D007234:Infant, Premature; D019102:Infant, Very Low Birth Weight; D016015:Logistic Models; D008297:Male; D010100:Oxygen / Q000097:blood*; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects; D012160:Retina; D012178:Retinopathy of Prematurity / Q000209:etiology* / Q000503:physiopathology; D012189:Retrospective Studies
chemical_list: D010100:Oxygen