title: Association between the occurrence of the anticardiolipin IgM and mite allergen-specific IgE antibodies in children with extrinsic type of atopic eczema/dermatitis syndrome.
abstract: BACKGROUND
  As the literature has only controversial data on the role of nonallergen-specific antibodies in atopic eczema dermatitis syndrome, the authors investigated the link between the occurrence of the antiphospholipid [anticardiolipin (ACL), anti-beta2-glycoprotein I] and allergen-specific immunoglobulin E (IgE) antibodies in 72 children with atopic eczema/dermatitis syndrome (AEDS).
  
  
  METHODS
  The measurement of antiphospholipid antibodies was carried out by enzyme-linked immunosorbent assay (ELISA), serum total IgE by nephelometry, and allergen-specific IgE by immunoblotting assay. The statistical analysis was carried out by Fisher's exact test and odds ratio was calculated.
  
  
  RESULTS
  Thirteen of 72 children with AEDS (mean age 8.3 years) had elevated serum levels of ACL, and eight anti-beta2-glycoprotein I antibodies. The presence of allergen-specific IgE against inhalant allergens and nutritive allergens was among eight of 13 and three of eight in the cases with elevated ACL. The ratio of patients with highly increased severity scoring of atopic dermatitis (SCORAD) index (>75) was significantly higher in the group with elevated (4/13) than in those with the normal ACL levels (2/59). There was a significant association between the appearance of mite (Dermatophagoides pteronyssinus, D. farinae)-specific IgE and ACL IgM antibodies (6/13).
  
  
  CONCLUSIONS
  These findings show that there are significant linkage and association between the appearance of ACL IgM or the production of allergen-specific IgE against inhalant (mainly mite) allergens in children with atopic eczema/dermatitis syndrome.
authors.affiliation: Borsod-A-Z County and University Teaching Hospital, Pediatric Health Centre, Miskolc, Hungary.
authors.forename: E
authors.initials: E
authors.lastname: Szakos
authors.forename: G
authors.initials: G
authors.lastname: Lakos
authors.forename: M
authors.initials: M
authors.lastname: Aleksza
authors.forename: E
authors.initials: E
authors.lastname: Gyimesi
authors.forename: G
authors.initials: G
authors.lastname: Páll
authors.forename: B
authors.initials: B
authors.lastname: Fodor
authors.forename: J
authors.initials: J
authors.lastname: Hunyadi
authors.forename: E
authors.initials: E
authors.lastname: Sólyom
authors.forename: S
authors.initials: S
authors.lastname: Sipka
mesh_terms: D000293:Adolescent; D000485:Allergens / Q000276:immunology; D000906:Antibodies / Q000097:blood*; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D000918:Antibody Specificity; D039741:Antigens, Dermatophagoides / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D008297:Male; D053482:beta 2-Glycoprotein I
chemical_list: D000485:Allergens; D000906:Antibodies; D017153:Antibodies, Anticardiolipin; D039741:Antigens, Dermatophagoides; D001323:Autoantibodies; D006023:Glycoproteins; D007075:Immunoglobulin M; D053482:beta 2-Glycoprotein I; D007073:Immunoglobulin E