title: [Antisense oligonucleotides with pharmacologic action].
abstract: The potential therapeutic applications of the antisense strategy are illustrated by numerous examples of the oligonucleotides investigated in preclinical and clinical trials especially for antiviral, antiinflammatory, anticancer and antiatherosclerotic activity. The main advantages of the antisense oligonucleotides therapeutic candidates are comparatively discussed with the classical drugs.
authors.affiliation: Disciplina de Chimie farmaceutică, Facultatea de Farmacie, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
authors.forename: Roxana-Georgiana
authors.initials: RG
authors.lastname: Tauşer
authors.forename: Ortansa
authors.initials: O
authors.lastname: Stoica
mesh_terms: D001161:Arteriosclerosis / Q000188:drug therapy; D002986:Clinical Trials as Topic; D017726:Cytomegalovirus Retinitis / Q000188:drug therapy; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D016376:Oligonucleotides, Antisense