title: Modelling of cardiovascular system: development of a hybrid (numerical-physical) model.
abstract: Physical models of the circulation are used for research, training and for testing of implantable active and passive circulatory prosthetic and assistance devices. However, in comparison with numerical models, they are rigid and expensive. To overcome these limitations, we have developed a model of the circulation based on the merging of a lumped parameter physical model into a numerical one (producing therefore a hybrid). The physical model is limited to the barest essentials and, in this application, developed to test the principle, it is a windkessel representing the systemic arterial tree. The lumped parameters numerical model was developed in LabVIEW environment and represents pulmonary and systemic circulation (except the systemic arterial tree). Based on the equivalence between hydraulic and electrical circuits, this prototype was developed connecting the numerical model to an electrical circuit--the physical model. This specific solution is valid mainly educationally but permits the development of software and the verification of preliminary results without using cumbersome hydraulic circuits. The interfaces between numerical and electrical circuits are set up by a voltage controlled current generator and a voltage controlled voltage generator. The behavior of the model is analyzed based on the ventricular pressure-volume loops and on the time course of arterial and ventricular pressures and flow in different circulatory conditions. The model can represent hemodynamic relationships in different ventricular and circulatory conditions.
authors.affiliation: Institute of Clinical Physiology, Section of Rome, CNR, Italy. gfr@itbm.rm.cnr.it
authors.forename: G
authors.initials: G
authors.lastname: Ferrari
authors.forename: M
authors.initials: M
authors.lastname: Kozarski
authors.forename: C
authors.initials: C
authors.lastname: De Lazzari
authors.forename: K
authors.initials: K
authors.lastname: Górczyńska
authors.forename: R
authors.initials: R
authors.lastname: Mimmo
authors.forename: M
authors.initials: M
authors.lastname: Guaragno
authors.forename: G
authors.initials: G
authors.lastname: Tosti
authors.forename: M
authors.initials: M
authors.lastname: Darowski
mesh_terms: D003326:Coronary Circulation / Q000502:physiology*; D004553:Electric Conductivity; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D009716:Numerical Analysis, Computer-Assisted; D011652:Pulmonary Circulation / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology*