title: Adhesins and invasins of pathogenic bacteria: a structural view.
abstract: Adhesion and invasion of pathogenic bacteria represent the important initial step of infection. Pathogens utilize surface-located adhesins/invasins for specific interaction with host cell receptors. The three-dimensional structures of a number of adhesins/invasins show that many are elongated molecules containing domains commonly found in eukaryotic proteins. Similar folds are employed repeatedly to target different receptors.
authors.affiliation: Department of Structural Biology, German Research Center for Biotechnology (GBF), Mascheroder Weg 1, 38124, Braunschweig, Germany.
authors.forename: Hartmut H
authors.initials: HH
authors.lastname: Niemann
authors.forename: Wolf Dieter
authors.initials: WD
authors.lastname: Schubert
authors.forename: Dirk W
authors.initials: DW
authors.lastname: Heinz
mesh_terms: D018829:Adhesins, Bacterial / Q000737:chemistry / Q000502:physiology*; D000818:Animals; D001419:Bacteria / Q000472:pathogenicity*; D001422:Bacterial Adhesion; D018407:Bacterial Physiological Phenomena; D006801:Humans; D008089:Listeria monocytogenes / Q000737:chemistry / Q000502:physiology; D008958:Models, Molecular; D013329:Structure-Activity Relationship; D037521:Virulence Factors / Q000502:physiology*; D015007:Yersinia / Q000737:chemistry / Q000502:physiology
chemical_list: D018829:Adhesins, Bacterial; D037521:Virulence Factors; C053476:invasin, Yersinia