[Topical immunosuppressors: new therapeutic approach in atopic dermatitis].
The efficiency of topical immunosuppressors in the treatment of atopic dermatitis is undebatable. These agents induce immunosuppression by inhibiting T cell activation and cytokine production. An intermittent treatment, with two applications per day, and photoprotection is recommended in adults and children aged more than two years. The precise position of the topical immunosuppressors in the treatment strategy of atopic dermatitis remains to be defined. Main side effects are irritative or allergic cutaneous reactions and cutaneous infections, no systemic side effects have been recorded. The consequence of long-term topical immunosuppression and specially the possible development of skin cancers in UV exposed skin, is not well known and necessitates careful monitoring of patients. These treatments are contra-indicated during pregnancy, breast feeding, in erythrodermic states and with any alterations of the cutaneous barrier.
Song
M
M
Service de Dermatologie, C.H.U. Saint-Pierre, U.L.B.
D000287:Administration, Topical; D000328:Adult; D002648:Child; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*
D007166:Immunosuppressive Agents