title: Cyclin E expression in papillary thyroid carcinoma: relation to staging.
abstract: Cyclin E plays a pivotal role in the regulation of G1-S transition and relates to malignant transformation of the cells. However, the clinical significance of cyclin E expression in patients with papillary thyroid carcinoma (PTC) remains unknown. We examined by immunohistochemistry the expression of cyclin E in 41 resected PTCs in pathologic stages from pT1a to pT4 and analyzed its relation to clinicohistopathologic factors. The positive staining was divided into 3 grades: no expression if less than 10%, expression if 11-50% and overexpression if more than 50% of the nuclei of tumor cells were stained positively. Cylin E expressions were observed in 75.6% of analyzed PTCs but only 60% of papillary microcarcinomas (PMCs) were immunopositive for cyclin E expression. However, cyclin E staining was observed in 90.4% of PTCs in a group with TNM higher than pT1a. The staining index was significantly different between the PMCs and the rest of the cancers investigated (14.91% +/- 14.4% vs. 34.03% +/- 23.44%, respectively; p < 0.005) and we observed positive relation between the staining index and factor T of staging of PTCs. All the lymph node metastases coexisted with cyclin E expression and most, but not all, of them coexisted with cyclin E overexpression. These findings indicate that cyclin E may play a key role for the oncogenesis and biologic behavior of PTC. If our results are confirmed in a larger study, a high level of cyclin E expression may become a new prognostic marker for PTCs.
authors.affiliation: Department of Endocrinological and General Surgery, Institute of Endocrinology, Medical University of Łódź, Łódź, Poland. mdedecjus@poczta.wp.pl
authors.forename: Jan
authors.initials: J
authors.lastname: Brzeziński
authors.forename: Adam
authors.initials: A
authors.lastname: Migodziński
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Gosek
authors.forename: Józef
authors.initials: J
authors.lastname: Tazbir
authors.forename: Marek
authors.initials: M
authors.lastname: Dedecjus
mesh_terms: D002277:Carcinoma / Q000378:metabolism*; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000378:metabolism*; D002453:Cell Cycle; D019927:Cyclin E / Q000096:biosynthesis* / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009367:Neoplasm Staging; D011379:Prognosis; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000378:metabolism*
chemical_list: D019927:Cyclin E