title: EI-2128-1, a novel interleukin-1beta converting enzyme inhibitor produced by Penicillium sp. E-2128.
abstract: EI-2128-1, a novel interleukin-1beta converting enzyme (ICE) inhibitor, was isolated from the culture broths of Penicillium sp. E-2128. EI-2128-1 selectively inhibited human recombinant ICE activity with IC50 value of 0.59 microM, without inhibiting elastase and cathepsin B. EI-2128-1 also inhibited mature interleukin-1beta secretion from THP-1 cells induced by LPS with IC50 value of 0.28 microM.
authors.affiliation: Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., 3-6-6 Asahimachi, Machida-shi, Tokyo 194-8533, Japan. fumito.koizumi@kyowa.co.jp
authors.forename: Fumito
authors.initials: F
authors.lastname: Koizumi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Agatsuma
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Ando
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Kondo
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Saitoh
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Matsuda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Nakanishi
mesh_terms: D061945:Caspase Inhibitors; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006801:Humans; D008826:Microbial Sensitivity Tests; D010407:Penicillium; D013141:Spiro Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D061945:Caspase Inhibitors; C482070:EI 2128-1; D004791:Enzyme Inhibitors; D004852:Epoxy Compounds; D013141:Spiro Compounds