Five new maleic and succinic acid derivatives from the mycelium of Antrodia camphorata and their cytotoxic effects on LLC tumor cell line.
Five new maleic and succinic acid derivatives were isolated from the mycelium of Antrodia camphorata. Their structures were determined by various spectroscopic means. Maleimide derivatives 2 and 3 showed appreciable cytotoxic activity against LLC cells.
Nakamura
Norio
N
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
Hirakawa
Akiko
A
Gao
Jiang-Jing
JJ
Kakuda
Hiroko
H
Shiro
Motoo
M
Komatsu
Yasuhiro
Y
Sheu
Chia-chin
CC
Hattori
Masao
M
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D008298:Maleates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D011124:Polyporaceae / Q000737:chemistry*; D019802:Succinic Acid / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013624:Taiwan; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D008298:Maleates; C030272:maleic acid; D019802:Succinic Acid