Prostate carcinoma: opportunities for translational research.
Adenocarcinoma of the prostate continues to be a major health concern. Although modern screening techniques have increased the number of men presenting with early stage disease, a significant population of men will present with intermediate or advanced pathological risk factors for recurrence. There are defined limitations in outcome with traditional therapies including surgery, radiation therapy, and hormone manipulation. Patients with intermediate and high-risk factors for treatment failure are candidates for protocols using translational research strategies incorporated into studies currently in development. These strategies may be able to selectively treat expression products of tumor and thus be more selective in the target for treatment. Carefully designed studies using these translational strategies have great potential in improving clinical outcome, tumor kill, and normal tissue tolerance in the care of these patients.
FitzGerald
T J
TJ
Department of Radiation Oncology, Worcester, Massachusetts 016555, USA. fitzgert@ummhc.org
Simon
Edmund
E
Meyer
Joshua
J
D001918:Brachytherapy / Q000379:methods; D051546:Cyclooxygenase 2; D003952:Diagnostic Imaging / Q000379:methods; D004358:Drug Therapy / Q000379:methods; D064420:Drug-Related Side Effects and Adverse Reactions; D066246:ErbB Receptors / Q000502:physiology; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D017430:Prostate-Specific Antigen / Q000097:blood / Q000187:drug effects / Q000528:radiation effects; D011471:Prostatic Neoplasms / Q000628:therapy*; D055502:Secondary Prevention; D042461:Vascular Endothelial Growth Factor A / Q000502:physiology
D007527:Isoenzymes; D008565:Membrane Proteins; D042461:Vascular Endothelial Growth Factor A; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D066246:ErbB Receptors; D017430:Prostate-Specific Antigen