title: Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738.
abstract: The synthesis and biological properties of a novel squalene epoxidase inhibitor, FR194738, are described. This compound displayed potent in vitro inhibitory activities against squalene epoxidase and cholesterol synthesis, and lowered plasma cholesterol and triglyceride levels in dogs.
authors.affiliation: Medicinal Biology Research Laboratories, Fujisawa Pharmaceutical Co Ltd, 2-1-6 Kashima, Yodogawa-ku, Osaka 532-8514, Japan. masae_sawada@po.fujisawa.co.jp
authors.forename: Masae
authors.initials: M
authors.lastname: Sawada
authors.forename: Ken ichi
authors.initials: Ki
authors.lastname: Washizuka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okumura
mesh_terms: D000818:Animals; D001596:Benzylamines / Q000138:chemical synthesis* / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood*; D004285:Dogs; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000201:enzymology*; D010105:Oxygenases / Q000037:antagonists & inhibitors*; D051381:Rats; D050603:Squalene Monooxygenase; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000097:blood*; D014407:Tumor Cells, Cultured
chemical_list: D001596:Benzylamines; D004791:Enzyme Inhibitors; C443179:FR 194738; D014280:Triglycerides; D002784:Cholesterol; D010105:Oxygenases; D050603:Squalene Monooxygenase