title: The tethered Biginelli condensation in natural product synthesis.
abstract: This review describes the development of the tethered Biginelli condensation and its application to the total synthesis of structurally complex, bioactive guanidine alkaloids.
authors.affiliation: Department of Chemistry, 516 Rowland Hall, University of California, Irvine, CA 92697-2025, USA.
authors.forename: Zachary D
authors.initials: ZD
authors.lastname: Aron
authors.forename: Larry E
authors.initials: LE
authors.lastname: Overman
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D001685:Biological Factors / Q000138:chemical synthesis* / Q000737:chemistry; D019791:Guanidine / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D011161:Porifera
chemical_list: D000470:Alkaloids; D001685:Biological Factors; D019791:Guanidine