[Combined interferon-alfa-2b and ribavirin therapy in patients with recurrent chronic hepatitis c after liver transplantation].
Interferon with ribavirin therapy has been proposed for the treatment of hepatitis C recurring in liver transplants.


OBJECTIVE
Was to assess the efficacy of standard combination therapy (interferon plus ribavirin) of chronic hepatitis C in transplanted patients with recurrent severe HCV induced chronic hepatitis.


METHODS
12 patients with HCV-PCR positive reaction (genotype 1b) were treated with the therapy of interferon-alpha-2b (3 MU three times a week) and 800-1000 mg ribavirin daily. Liver biopsy had been done in every patients before and after the treatment. Study endpoints were the end of treatment and the 6 month post-therapy sustained virologic response.


RESULTS
At the end of treatment 3 patients were negative for HCV-PCR and all of them had negative reaction after 6 month follow-up period.


CONCLUSIONS
The results are in a good accordance with treatment of patients with chronic hepatitis C without liver transplantation.
Lengyel
Gabriella
G
Semmelweis Egyetem, Altalános Orvostudományi Kar, II. Belklinika, Budapest.
Kóbori
László
L
Fehérvári
Imre
I
Nemes
Balázs
B
Görög
Dénes
D
Patonai
Attila
A
Sárváry
Enikö
E
Varga
Marina
M
Perner
Ferenc
F
Fehér
János
J
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000998:Antiviral Agents / Q000627:therapeutic use*; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D019698:Hepatitis C, Chronic / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D012008:Recurrence; D012189:Retrospective Studies; D012254:Ribavirin / Q000627:therapeutic use*; D012720:Severity of Illness Index; D016896:Treatment Outcome
D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D012254:Ribavirin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin