title: New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa.
abstract: The ethyl acetate extract of Penicillium sp., derived from the Mediterranean sponge Axinella verrucosa, yielded the known compound communesin B (1) and its new congeners communesins C (2) and D (3), as well as the known compounds griseofulvin, dechlorogriseofulvin, and oxaline. All structures were unambiguously established by 1D and 2D NMR and MS data. In several bioassays performed on different leukemia cell lines, the communesins exhibited moderate antiproliferative activity.
authors.affiliation: Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, Geb.26.23, D-40225 Düsseldorf, Germany.
authors.forename: Raquel
authors.initials: R
authors.lastname: Jadulco
authors.forename: Ru Angelie
authors.initials: RA
authors.lastname: Edrada
authors.forename: Rainer
authors.initials: R
authors.lastname: Ebel
authors.forename: Albrecht
authors.initials: A
authors.lastname: Berg
authors.forename: Karsten
authors.initials: K
authors.lastname: Schaumann
authors.forename: Victor
authors.initials: V
authors.lastname: Wray
authors.forename: Klaus
authors.initials: K
authors.lastname: Steube
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006118:Griseofulvin / Q000302:isolation & purification; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007558:Italy; D008522:Mediterranean Sea; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D011161:Porifera; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D006576:Heterocyclic Compounds, 4 or More Rings; C483283:communesin B; C483284:communesin C; C483285:communesin D; D006118:Griseofulvin