MicroRNAs: genomics, biogenesis, mechanism, and function.
MicroRNAs (miRNAs) are endogenous approximately 22 nt RNAs that can play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression. Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
Bartel
David P
DP
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA. dbartel@wi.mit.edu
D000818:Animals; D001483:Base Sequence; D017173:Caenorhabditis elegans; D004330:Drosophila; D016678:Genome; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D008954:Models, Biological; D008969:Molecular Sequence Data; D010641:Phenotype; D010940:Plant Proteins / Q000502:physiology; D014176:Protein Biosynthesis; D034741:RNA, Small Interfering / Q000378:metabolism; D013045:Species Specificity; D014158:Transcription, Genetic
D035683:MicroRNAs; D010940:Plant Proteins; D034741:RNA, Small Interfering