Dual intracellular signaling by proteolytic cleavage of membrane-anchored heparin-binding EGF-like growth factor.
Heparin-binding EGF-like growth factor (HB-EGF), a member of the EGF family, is synthesized as a membrane-anchored precursor (proHB-EGF) that is cleaved to release a soluble HB-EGF by specific metalloproteases. Proteolytic cleavage of proHB-EGF yields amino- and carboxy-terminal fragments (HB-EGF and HB-EGF-C). Recent studies indicate that the processing of proHB-EGF is strictly regulated and involved in a variety of biological processes and that not only HB-EGF but also HB-EGF-C functions as a signaling molecule. ProHB-EGF generates dual intracellular signaling molecules by its proteolytic cleavage.
Nanba
Daisuke
D
Department of Medical Biochemistry, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime 791-0295, Japan.
Higashiyama
Shigeki
S
D000818:Animals; D006332:Cardiomegaly; D002462:Cell Membrane / Q000378:metabolism*; D003593:Cytoplasm / Q000473:pathology; D004815:Epidermal Growth Factor / Q000737:chemistry / Q000502:physiology*; D006493:Heparin / Q000378:metabolism*; D066257:Heparin-binding EGF-like Growth Factor; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008954:Models, Biological; D009206:Myocardium / Q000473:pathology; D017434:Protein Structure, Tertiary; D015398:Signal Transduction; D013363:Submandibular Gland / Q000502:physiology; D014945:Wound Healing
C587883:HBEGF protein, human; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D004815:Epidermal Growth Factor; D006493:Heparin