title: Starvation response in mouse liver shows strong correlation with life-span-prolonging processes.
abstract: We have monitored global changes in gene expression in mouse liver in response to fasting and sugar-fed conditions using high-density microarrays. From approximately 20,000 different genes, the significantly regulated ones were grouped into specific signaling and metabolic pathways. Striking changes in lipid signaling cascade, insulin and dehydroepiandrosterone (DHEA) hormonal pathways, urea cycle and S-adenosylmethionine-based methyl transfer systems, and cell apoptosis regulators were observed. Since these pathways have been implicated to play a role in the aging process, and since we observe significant overlap of genes regulated upon starvation with those regulated upon caloric restriction, our analysis suggests that starvation may elicit a stress response that is also elicited during caloric restriction. Therefore, many of the signaling and metabolic components regulated during fasting may be the same as those which mediate caloric restriction-dependent life-span extension.
authors.affiliation: Institut fuer Genetik, Forschungszentrum Karlsruhe, 76021 Karlsruhe, , Germany.
authors.forename: Matthias
authors.initials: M
authors.lastname: Bauer
authors.forename: Anne C
authors.initials: AC
authors.lastname: Hamm
authors.forename: Melanie
authors.initials: M
authors.lastname: Bonaus
authors.forename: Andrea
authors.initials: A
authors.lastname: Jacob
authors.forename: Jens
authors.initials: J
authors.lastname: Jaekel
authors.forename: Hubert
authors.initials: H
authors.lastname: Schorle
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Pankratz
authors.forename: Joerg D
authors.initials: JD
authors.lastname: Katzenberger
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000096:biosynthesis / Q000235:genetics; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D000090702:Constitutive Androstane Receptor; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000235:genetics; D003687:Dehydroepiandrosterone / Q000378:metabolism; D005215:Fasting / Q000378:metabolism*; D005223:Fats / Q000378:metabolism; D020869:Gene Expression Profiling; D008099:Liver / Q000378:metabolism*; D008136:Longevity / Q000502:physiology*; D008297:Male; D008780:Methyltransferases / Q000096:biosynthesis / Q000235:genetics; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear / Q000096:biosynthesis / Q000235:genetics; D011987:Receptors, Steroid / Q000096:biosynthesis / Q000235:genetics; D012436:S-Adenosylmethionine / Q000378:metabolism; D013002:Somatomedins / Q000378:metabolism; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics; D014508:Urea / Q000378:metabolism
chemical_list: D018528:ATP-Binding Cassette Transporters; D000596:Amino Acids; D002352:Carrier Proteins; D000090702:Constitutive Androstane Receptor; D005223:Fats; D000077297:Pregnane X Receptor; D018160:Receptors, Cytoplasmic and Nuclear; D011987:Receptors, Steroid; D013002:Somatomedins; D014157:Transcription Factors; D003687:Dehydroepiandrosterone; D012436:S-Adenosylmethionine; D014508:Urea; D003577:Cytochrome P-450 Enzyme System; D002784:Cholesterol; D008780:Methyltransferases