Immunization of egg-allergic individuals with egg- or chicken-derived vaccines.
Viruses used in several vaccines are propagated in embryonated eggs. These vaccines contain variable quantities of residual egg or chicken proteins and pose risks when administered to egg- or chicken-sensitive persons. This article highlights differences in how vaccines are prepared, with emphasis on the quantitation of residual egg-derived protein in each vaccine. Published reports on the frequency and severity of these vaccine-induced allergic reactions are reviewed, and an algorithm is provided for the preimmunization evaluation of egg-sensitive persons.
Kelso
John M
JM
Allergy Division, Naval Medical Center San Diego, CA 92134-5000, USA. JMKelso@nmcsd.med.navy.mil
Yunginger
John W
JW
D000328:Adult; D000818:Animals; D002645:Chickens / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D021181:Egg Hypersensitivity / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007114:Immunization / Q000009:adverse effects*; D010063:Ovum / Q000276:immunology*; D012882:Skin Tests; D014612:Vaccines / Q000009:adverse effects* / Q000276:immunology*
D014612:Vaccines