Second primary breast cancer after Hodgkin's disease.
Although the potential carcinogenic risk of radiotherapy is well known, it has become clear that there is a particularly high risk of radiation-induced breast cancer in women treated for Hodgkin's disease at young ages. Thankfully, death from breast cancer in this population is uncommon, but it is important to understand factors contributing to the risk, including treatment parameters, and to develop a logical and efficient method for medical management of those at risk. In this minireview, we examine the evidence which should inform such a management policy.
Horwich
A
A
Academic Unit of Radiotherapy and Oncology, The Royal Marsden NHS Trust and the Institute of Cancer Research, Downs Road, Sutton, Surrey SM2 5NG, UK. alan.horwich@icr.ac.uk
Swerdlow
A J
AJ
D005260:Female; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000473:pathology* / Q000628:therapy; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000628:therapy; D012307:Risk Factors