Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach.
Bays
Harold
H
Diabetes Division, University of Texas Health Science Center, San Antonio, Texas 78229, USA.
Mandarino
Lawrence
L
DeFronzo
Ralph A
RA
D017667:Adipocytes; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000209:etiology*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D006801:Humans; D050356:Lipid Metabolism; D009765:Obesity / Q000150:complications* / Q000473:pathology; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists*; D014157:Transcription Factors / Q000819:agonists*
D005230:Fatty Acids, Nonesterified; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors