Female sterilization with quinacrine using hysterosalpingography (HSG) as an endpoint after a single-insertion protocol in Caracas, Venezuela.
To evaluate the intrauterine insertion of quinacrine as an alternative nonsurgical female sterilization method by confirming bilateral occlusion of the fallopian tubes using HSG in a group of women who desire permanent sterilization.



After doing hysterosalpingography to confirm patency of both fallopian tubes, 324 mg of quinacrine were introduced with a modified IUD inserter in 30 patients who came to Concepción Palacios Maternity Hospital seeking permanent sterilization, between June 2000 and September 2001. Follow-up with HSG was done 3 months later to verify occlusion of the fallopian tubes.



26 of 30 patients (86%) had bilateral tubal occlusion as determined by HSG. There were minor side effects such as: pain (66.7%), yellow discharge (100%) and menstrual abnormalities (13.3%). One woman became pregnant after HSG showed bilateral occlusion. HSG may interfere with the action of the quinacrine.



QS is a simple and safe alternative to surgical sterilization with few side effects.
Giugni Chalbaud
A
A
Concepción Palacios Maternity Hospital, Caracas, Venezuela. aldoyu@hotmail.com
Plaza Mora
G
G
D000328:Adult; D004343:Drug Implants; D005187:Fallopian Tubes / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007047:Hysterosalpingography; D017063:Outcome Assessment, Health Care; D011247:Pregnancy; D011446:Prospective Studies; D011796:Quinacrine / Q000008:administration & dosage*; D012102:Reproductive Control Agents / Q000008:administration & dosage*; D013246:Sterilization, Tubal; D014687:Venezuela
D004343:Drug Implants; D012102:Reproductive Control Agents; D011796:Quinacrine