title: Endometrial intraepithelial neoplasia diagnosed at endometrial resection.
abstract: The literature has no reported cases of isolated endometrial intraepithelial neoplasia found at endometrial resection. If endometrial cancer is occult it might not be detected at diagnostic hysteroscopy or during resection, especially if destructive techniques are used. A 51-year-old woman had history of menorrhagia, with diagnostic hysteroscopy showing benign functional endometrium and diagnosed as dysfunctional uterine bleeding. Endometrial resection was performed and the pathologic examination in one stripe of resected tissue found focal, isolated endometrial intraepithelial neoplasia. This case reinforces the importance of pathologic tissue examination after endometrial ablation. Care must be taken when performing second-generation nonhysteroscopic ablation techniques, as even with direct visualization a premalignant lesion can be missed.
authors.affiliation: Department of Gynecology, Santa Cristina University Hospital, O'Donnell, 59, Madrid 28009, Spain.
authors.forename: Tirso
authors.initials: T
authors.lastname: Perez-Medina
authors.forename: José
authors.initials: J
authors.lastname: Bajo-Arenas
authors.forename: Luis
authors.initials: L
authors.lastname: Sanfrutos
authors.forename: Javier
authors.initials: J
authors.lastname: Haya
authors.forename: Silvia
authors.initials: S
authors.lastname: Iniesta
authors.forename: Javier
authors.initials: J
authors.lastname: Vargas
mesh_terms: D002278:Carcinoma in Situ / Q000473:pathology* / Q000601:surgery; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000601:surgery; D004717:Endometrium / Q000473:pathology* / Q000601:surgery; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods; D006801:Humans; D015907:Hysteroscopy / Q000379:methods*; D008595:Menorrhagia / Q000601:surgery