title: Glaucoma in Ghana, West Africa: clinical features and the role of mutations in Myocilin.
abstract: POAG is a severely debilitating disease in West Africa. Currently, many patients seem to be misclassified as having POAG who in fact have CACG. Improved examination techniques, including routine gonioscopy, would increase diagnostic accuracy and improve treatment strategies. The incidence of Myocilin mutations in this group of individuals is similar to that found in other populations around the world. Myocilin plays a limited role in the pathogenesis of POAG in this population.
authors.affiliation: Duke University Eye Center, Erwin Road, Box 3802, Durham, NC 27710, USA. hernd012@mc.duke.edu
authors.forename: Leon W
authors.initials: LW
authors.lastname: Herndon
authors.forename: Pratap
authors.initials: P
authors.lastname: Challa
authors.forename: R Rand
authors.initials: RR
authors.lastname: Allingham
mesh_terms: D000328:Adult; D000368:Aged; D003598:Cytoskeletal Proteins; D004252:DNA Mutational Analysis; D005136:Eye Proteins / Q000235:genetics*; D005260:Female; D005869:Ghana / Q000453:epidemiology; D005901:Glaucoma / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics*; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D000099179:Myocilin
chemical_list: D003598:Cytoskeletal Proteins; D005136:Eye Proteins; D006023:Glycoproteins; D000099179:Myocilin