Intact mutS in laboratory-derived and clinical glycopeptide-intermediate Staphylococcus aureus strains.
The mutS gene of the methyl-directed mismatch repair system was sequenced in 10 parent and glycopeptide-intermediate Staphylococcus aureus strains. The mutS gene was intact in all strains studied. Hence, mutations in this gene had played no role in the development of vancomycin resistance in these strains.
Muthaiyan
Arunachalam
A
Microbiology Group, Department of Biological Sciences, Illinois State University, Normal, Illinois 61790-4120, USA.
Jayaswal
Radheshyam K
RK
Wilkinson
Brian J
BJ
D000251:Adenosine Triphosphatases / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D020137:Base Pair Mismatch / Q000235:genetics; D001483:Base Sequence; D004260:DNA Repair / Q000235:genetics; D004269:DNA, Bacterial / Q000096:biosynthesis / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D006020:Glycopeptides / Q000235:genetics*; D016106:Methicillin Resistance / Q000235:genetics; D008969:Molecular Sequence Data; D051719:MutS DNA Mismatch-Binding Protein; D009154:Mutation / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics* / Q000254:growth & development; D020713:Vancomycin Resistance / Q000235:genetics
D001426:Bacterial Proteins; D004269:DNA, Bacterial; D004268:DNA-Binding Proteins; D006020:Glycopeptides; D000251:Adenosine Triphosphatases; D051719:MutS DNA Mismatch-Binding Protein