title: [Studies on fluoride concentration and cholinesterase activity in rat hippocampus].
abstract: OBJECTIVE
  To study the accumulation of fluoride in rat hippocampus and its effect on cholinesterase activity.
  
  
  METHODS
  Rats were subchronically exposed to NaF, and fluoride concentration and cholinesterase activity in rat hippocampus were determined.
  
  
  RESULTS
  Fluoride concentration in rat hippocampus was significantly correlated with the dosage of fluoride, and there were significant differences among high dosage group [(13.03 +/- 1.79) micro g/g], low dosage group [(9.83 +/- 0.92) micro g/g] and control [(8.27 +/- 1.11) micro g/g], P < 0.01. Acetylcholinesterase activities among three groups [(0.111 +/- 0.031) micro mol/mg, (0.143 +/- 0.025) micro mol/mg, (0.183 +/- 0.027) micro mol/mg] were also significantly different (P < 0.01), which was negatively correlated with fluoride concentration in rat hippocampus (r = -0.700, P < 0.01). The activity of butylcholinesterase in high dosage group [(0.041 +/- 0.010) micro mol/mg] was different from that of control [(0.067 +/- 0.025) micro mol/mg, P < 0.05], but the activity was not significantly related with fluoride concentration in rat hippocampus (r = -0.317, P = 0.094).
  
  
  CONCLUSIONS
  Fluoride may go through the blood-brain barrier and accumulate in rat hippocampus, and inhibit the activity of cholinesterase.
authors.affiliation: School of Public Health, Anhui Medical University, Hefei 230032, China.
authors.forename: Jin-xia
authors.initials: JX
authors.lastname: Zhai
authors.forename: Zhi-yong
authors.initials: ZY
authors.lastname: Guo
authors.forename: Chuan-lai
authors.initials: CL
authors.lastname: Hu
authors.forename: Qi-nan
authors.initials: QN
authors.lastname: Wang
authors.forename: Qi-xing
authors.initials: QX
authors.lastname: Zhu
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001812:Blood-Brain Barrier; D002091:Butyrylcholinesterase / Q000378:metabolism*; D005458:Fluoride Poisoning / Q000378:metabolism*; D005459:Fluorides / Q000493:pharmacokinetics*; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D005459:Fluorides