[Visible spectrophotometric assay of ranitidine].
Ranitidine, belonging to H2-antagonist group, is a compound containing a furanic moiety and is used in peptic ulcer therapy. This paper debates the possibility of developing a new visible spectrophotometric assessment by using the reaction between ranitidine and eosine. We carried out our determinations at 505 nm, where the absorbency of ranitidine-eosine complex is maximal, and we have established the optimal reaction conditions. This method was successfully applied for ranitidine assay from pharmaceutical dosage forms.
Apostu
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Disciplina Chimie analitică şi Analiză instrumentală, Facultatea de Farmacie, Universitatea de Medicina şi Farmacie Gr.T. Popa Iaşi.
Dorneanu
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V
Bibire
Nela
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D000465:Algorithms; D004801:Eosine Yellowish-(YS) / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006635:Histamine H2 Antagonists / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D010437:Peptic Ulcer / Q000188:drug therapy; D011899:Ranitidine / Q000737:chemistry* / Q000627:therapeutic use; D013053:Spectrophotometry / Q000379:methods
D005456:Fluorescent Dyes; D006635:Histamine H2 Antagonists; D011899:Ranitidine; D004801:Eosine Yellowish-(YS)