Developmental regulation of the rabbit blood-brain barrier LAT1 large neutral amino acid transporter mRNA and protein.
The expression of the blood-brain barrier (BBB) LAT1 large neutral amino acid transporter mRNA and protein was investigated in development in rabbits. The BBB LAT1 mRNA was down-regulated with postnatal development. However, the BBB immunoreactive LAT1 protein was unchanged in postnatal development, despite an up-regulation of the BBB GLUT1 glucose transporter protein during this period. The dissociation between LAT1 protein and mRNA levels in development is consistent with posttranscriptional regulation of BBB LAT1 gene expression.
Boado
Ruben J
RJ
Department of Medicine, University of California at Los Angeles, CA 90024, USA. rboado@mednet.ucla.edu
Li
Jian Yi
JY
Pardridge
William M
WM
D000375:Aging / Q000502:physiology; D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D051272:Glucose Transporter Type 1; D027283:Large Neutral Amino Acid-Transporter 1 / Q000235:genetics / Q000378:metabolism*; D009004:Monosaccharide Transport Proteins / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D011817:Rabbits
D051272:Glucose Transporter Type 1; D027283:Large Neutral Amino Acid-Transporter 1; D009004:Monosaccharide Transport Proteins; D012333:RNA, Messenger