Allograft arteriopathy: pathogenesis update.
Allograft arteriopathy is a vascular intimal proliferative process that occurs in all solid organ transplants and stands as the single most significant obstacle to successful long-term solid organ transplantation; it shares a number of pathologic features with restenosis lesions and atherosclerosis. This article will review some of the newer developments in our understanding of the immunological and vascular biology underpinnings of the disease, including the roles played by cytokine and chemokine mediators in recruiting and activating both inflammatory cells, as well as smooth muscle cell precursors.
Mitchell
Richard N
RN
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 77 Avenue Louis Pasteur/NRB 730D, Boston, MA 02115, USA. rmitchell@rics.bwh.harvard.edu
D001161:Arteriosclerosis / Q000276:immunology / Q000473:pathology*; D001808:Blood Vessels / Q000473:pathology*; D016207:Cytokines / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology / Q000503:physiopathology*; D014184:Transplantation, Homologous / Q000473:pathology; D019737:Transplants
D016207:Cytokines