Plotting haplotype-specific linkage disequilibrium patterns by extended haplotype homozygosity.
Association studies may request more details of a specific haplotype. Haplotype-specific decay of linkage disequilibrium is such a crucial and versatile characteristic. It may be used, e.g. to search for signals of natural selection in a risk haplotype. Here, we present a web-based tool to explore the relationship between population frequency and extended linkage disequilibrium measured as haplotype homozygosity of observed haplotypes within a specified candidate region.


BACKGROUND
The web-tool is available at http://ihg.gsf.de/cgi-bin/mueller/webehh.pl
Mueller
Jakob C
JC
Institute of Human Genetics, GSF, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany. jakob.mueller@gsf.de
Andreoli
Christophe
C
D000465:Algorithms; D002874:Chromosome Mapping / Q000379:methods*; D003196:Computer Graphics; D020869:Gene Expression Profiling / Q000379:methods*; D006239:Haplotypes; D006720:Homozygote; D020407:Internet; D015810:Linkage Disequilibrium / Q000235:genetics*; D010363:Pattern Recognition, Automated; D017422:Sequence Analysis, DNA / Q000379:methods; D012984:Software; D014584:User-Computer Interface