Changes in focal macular ERGs after macular translocation surgery with 360 degrees retinotomy.
OBJECTIVE
To evaluate the short- and long-term changes of focal macular electroretinograms (fmERGs) after macular translocation with 360 degrees retinotomy.


METHODS
This was a retrospective study. fmERGs were recorded in 19 eyes of 19 consecutive patients who underwent macular translocation with 360 degrees retinotomy for choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD; 17 eyes) or polypoidal choroidal vasculopathy (2 eyes). The changes in the fmERGs, recorded before, shortly after (6-12 months; mean 8.3 months), and more than 18 months (18-30 months; mean 22.4 months) after surgery from 12 eyes, were analyzed. A 15 degrees stimulus centered on the fovea was used to elicit the fmERGs.


RESULTS
The mean logarithm of minimum angle of resolution (logMAR) was 1.06 +/- 0.07 (20/230) before surgery, 0.78 +/- 0.08 (20/121) early after surgery (n = 19), and 0.64 +/- 0.07 (20/87) late after surgery (n = 12). These improvements in visual acuity were significant (P = 0.0074, P = 0.0050, respectively). Before surgery, the amplitudes of all components of the fmERGs were markedly reduced in all eyes. The mean b-wave amplitude in 17 AMD eyes recorded early after surgery was significantly larger (P = 0.0262), and the mean a-wave amplitude was also increased but not significantly (P = 0.1180). The mean amplitudes of the a- and b-waves in 10 AMD eyes recorded after 18 months were significantly larger than those before the surgery (P = 0.0218, and P = 0.0284). The mean implicit time of the b-wave in 17 AMD eyes decreased early after surgery, and a further decrease was detected at the later testing time.


CONCLUSIONS
These results indicate that macular function is partially recoverable after macular translocation in some patients.
Terasaki
Hiroko
H
Department of Ophthalmology, Nagoya University School of Medicine, Nagoya, Japan. terasaki@med.nagoya-u.ac.jp
Ishikawa
Kohei
K
Niwa
Yasuhiro
Y
Piao
Chang-Hua
CH
Niwa
Takashi
T
Kondo
Mineo
M
Ito
Yasuki
Y
Miyake
Yozo
Y
D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery; D004596:Electroretinography; D005260:Female; D006801:Humans; D008268:Macular Degeneration / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012160:Retina / Q000502:physiology* / Q000637:transplantation*; D012189:Retrospective Studies; D014792:Visual Acuity