Misoprostol administration in first-trimester pregnancies with embryonic demise reduces uterine arterial blood flow.
OBJECTIVE
This study was designed to evaluate the effect of misoprostol on the blood flow in uterine arteries of pregnant women with first-trimester embryonic demise.


METHODS
Transvaginal ultrasonographic Doppler examinations (resistance index, pulsatility index, systolic/diastolic ratio) of the uterine arteries in 61 pregnant women were performed before misoprostol administration and 90 min later. Following baseline Doppler measurements, each woman received 200 microg misoprostol intravaginally and 200 microg misoprostol orally.


CONCLUSIONS
All Doppler indices increased significantly after misoprostol administration (p < 0.0001), suggesting an increase in flow resistance.
Turan
C
C
Department of Obstetrics and Gynecology, Kartal Education and Research Hospital, Istanbul, Turkey.
Koc
N
N
Dansuk
R
R
Cengizoglu
B
B
Mericeli
D S
DS
Unal
O
O
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage* / Q000009:adverse effects; D000028:Abortion, Induced; D000030:Abortion, Missed; D000282:Administration, Intravaginal; D000293:Adolescent; D000328:Adult; D001158:Arteries / Q000000981:diagnostic imaging / Q000502:physiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011673:Pulsatile Flow / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D018608:Ultrasonography, Doppler; D014599:Uterus / Q000098:blood supply* / Q000000981:diagnostic imaging
D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol