title: Early onset of severe diabetes mellitus-related microvascular complications.
abstract: A 16-year-old girl with type 1 diabetes developed painful peripheral neuropathy within 1 month and proliferative retinopathy within 1 year despite excellent glycemic control. We speculate on potential mechanisms that may have contributed to the rapid development of diabetes mellitus-related complications.
authors.affiliation: Departments of Pediatrics and Medicine, the Hospital for Sick Children and University Health Network, University of Toronto, Toronto, Ontario, Canada. jill.hamilton@sickkids.ca
authors.forename: Jill
authors.initials: J
authors.lastname: Hamilton
authors.forename: Mijin
authors.initials: M
authors.lastname: Brown
authors.forename: Robert
authors.initials: R
authors.lastname: Silver
authors.forename: Denis
authors.initials: D
authors.lastname: Daneman
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications*; D003929:Diabetic Neuropathies / Q000209:etiology*; D003930:Diabetic Retinopathy / Q000209:etiology*; D005260:Female; D006801:Humans
chemical_list: D001786:Blood Glucose