title: Combinatorial chemistry of beta-hairpins.
abstract: Combinatorial chemistry is expanding rapidly both in terms of chemistry development and application to the synthesis of compound libraries for lead discovery and optimization. Combinatorial technologies continue evolving and developing, in fact they are being used as basic research tools in different fields that include peptide/protein folding. This review examines the use of combinatorial chemistry in the design of peptides and protein domains that adopt beta-sheet conformations. In particular, the use of conformationally restricted peptide libraries has allowed the identification of linear peptides that are folded in a beta-hairpin structure in plain aqueous solutions.
authors.affiliation: Departament de Bioquímica i Biologia Molecular, Universitat de València, Burjassot, Valencia, Spain.
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Pastor
authors.forename: Enrique
authors.initials: E
authors.lastname: Pérez-Payá
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry*; D017433:Protein Structure, Secondary
chemical_list: D019151:Peptide Library; D010455:Peptides