title: Octenidine hydrochloride in hydatid disease.
abstract: Hydatid disease is still endemic in many devoloping countries and continues to be an important cause of morbidity. The objective of this study was to determine the in vitro scolicidal effects of octenidine hydrochloride in different concentrations using different exposure times. After hydatid cyst liquid was left to precipitate for 1 h to obtain cystic sand, various concentrations of octenidine (undiluted, 1% and 0.1% diluted) were added to concentrated hydatid cyst sediments for 5, 10, 15, 20, 25, 30, 45, and 60 min, and scolicidal effects of octenidine were compared with 20% saline and control group for the same times. It was found that undiluted octenidine had a strong scolicidal effect at 15 min compared to saline at 20%. One percent octenidine had a scolicidal effect at 30 min. However, 0.1% octenidine did not have enough scolicidal effect in 1 h. It was concluded that undiluted and 1% diluted octenidine might be used for scolicidal purpose in the treatment of hydatid disease.
authors.affiliation: Department of Microbiology and Clinical Microbiology, Afyon Kocatepe University, Afyon, Turkey. maltindis@hotmail.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Altindis
authors.forename: Yuksel
authors.initials: Y
authors.lastname: Arikan
authors.forename: Zafer
authors.initials: Z
authors.lastname: Cetinkaya
authors.forename: Coskun
authors.initials: C
authors.lastname: Polat
authors.forename: Sezgin
authors.initials: S
authors.lastname: Yilmaz
authors.forename: Gökhan
authors.initials: G
authors.lastname: Akbulut
authors.forename: Osman Nuri
authors.initials: ON
authors.lastname: Dilek
authors.forename: Ozcan
authors.initials: O
authors.lastname: Gokce
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004444:Echinococcosis, Hepatic / Q000188:drug therapy*; D004446:Echinococcus / Q000187:drug effects* / Q000254:growth & development; D007097:Imines; D066298:In Vitro Techniques; D011725:Pyridines / Q000494:pharmacology*; D012756:Sheep
chemical_list: D000890:Anti-Infective Agents; D007097:Imines; D011725:Pyridines; C034213:octenidine