title: Pubescenes, jatrophane diterpenes, from Euphorbia pubescens, with multidrug resistance reversing activity on mouse lymphoma cells.
abstract: The macrocyclic jatrophane diterpene polyesters, pubescenes A - D ( 1 - 4) were isolated from the whole dried plant of Euphorbia pubescens, and evaluated for multidrug resistance (MDR) reversing activity on mouse lymphoma cells. All the compounds displayed very strong activity compared with the positive control verapamil. Pubescene D ( 4) is a new compound, whose structure was established as 3beta,9alpha,-diacetoxy-7beta-benzoyloxy-15beta-hydroxy-14-oxo-2beta H-jatropha-5 E,12 E-diene by spectroscopic methods, including (1)H- (1)H COSY, HMQC, HMBC and NOESY.
authors.affiliation: Centro de Estudos de Ciências Farmacêuticas, Faculdade de Farmácia da Universidade de Lisboa, Lisboa, Portugal.
authors.forename: Cláudia
authors.initials: C
authors.lastname: Valente
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Ferreira
authors.forename: Pedro M
authors.initials: PM
authors.lastname: Abreu
authors.forename: Nora
authors.initials: N
authors.lastname: Gyémánt
authors.forename: Katalin
authors.initials: K
authors.lastname: Ugocsai
authors.forename: Judit
authors.initials: J
authors.lastname: Hohmann
authors.forename: Joseph
authors.initials: J
authors.lastname: Molnár
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor / Q000187:drug effects; D004224:Diterpenes / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D028481:Euphorbia; D008223:Lymphoma; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D004224:Diterpenes; D010936:Plant Extracts; C468576:jatrophene diterpene; C483068:pubescene A; C483066:pubescene B; C483067:pubescene C