[Potential and limitations of fluorescence diagnosis and photodynamic therapy. Part I: Fluorescence diagnosis].
Fluorescence diagnostic methods enable tumor visualization via specific excitation of endogenous or exogenous tumor-selective fluorescent markers and subsequent optical measurement of the induced fluorescence signals. In the following review, the reader will be given a clear and extensive understanding of all aspects of these methods relevant for ENT specialists. Apart from a demonstration of the clinical difficulties in the diagnosis of malignant tumors of the upper aerodigestive tract, a historical synopsis of fluorescence diagnosis and an explanation of the biophysical basics, this publication focuses mainly on a detailed discussion of the current status of research and a critical consideration of the commercially available systems for fluorescence diagnosis in ENT oncology. The topic is rounded off by a short account of possible future activities in this field.
Betz
C S
CS
Klinik für Hals-. Nasen- und Ohrenheilkunde, Ludwig-Maximilians-Universität, klinkum Grosshadern, Munich. cbetz@life.med.uni-muenchen.de
Leunig
A
A
D020680:Bronchoscopes; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology; D019723:Endoscopes; D005456:Fluorescent Dyes; D005470:Fluorometry / Q000295:instrumentation*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D020704:Laryngoscopes; D010039:Otorhinolaryngologic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D011166:Porphyrins / Q000378:metabolism*; D012680:Sensitivity and Specificity
D005456:Fluorescent Dyes; D011166:Porphyrins