DNA microarrays in vaccine research.
DNA microarrays represent the technology platform for a wide variety of analytical methods built around the detection of sequence-specific nucleic acid hybridization. They allow the analysis of complex biological systems on the basis of the genome and transcriptome with high simplicity, efficiency, sensitivity and specificity. This positions DNA microarrays as ideal tools for novel approaches in biomedical research and explains the tremendous pace at which they are being applied to an enormous variety of systems and projects. Recently, vaccine researchers began to use DNA microarrays for the identification of vaccine candidates against bacterial, parasitic and viral pathogens, as well as tumors. Here, DNA microarrays as a technology platform in these areas of vaccine research are reviewed and their limitations, as well as their potential for future applications in vaccinology, critically evaluated.
Dietrich
Guido
G
Berna Biotech Ltd, Vaccine Research, Rehhagstr 79, CH-3018 Berne, Switzerland. guido.dietrich@bernabiotech.com
D001428:Bacterial Vaccines; D019496:Cancer Vaccines; D020869:Gene Expression Profiling; D017125:Genes, Protozoan; D016680:Genome, Bacterial; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D014765:Viral Vaccines
D001428:Bacterial Vaccines; D019496:Cancer Vaccines; D014765:Viral Vaccines