[Synthesis and antiviral activity of ureides and carbamates of betulinic acid and its derivatives].
Ureides and carbamates of betulinic acid and its derivatives were prepared in good yields by interaction of betulinic acid, betulonic acid, and betulonic acid 3-oxime with amines, amino acids, and alcohols. Ureides of betulonic acid containing L-Val and L-Met residues were found to be effective against herpes simplex type 1 virus. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2003, vol. 29, no. 6; see also http://www.maik.ru.
Flekhter
O B
OB
Institute of Organic Chemistry, Ufa Scientific Center, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, 450054 Russia. obf@anrb.ru
Boreko
E I
EI
Nigmatullina
L R
LR
Tret'iakova
E V
EV
Pavlova
N I
NI
Baltina
L A
LA
Nikolaeva
S N
SN
Savinova
O V
OV
Galin
F Z
FZ
Tolstikov
G A
GA
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002219:Carbamates / Q000138:chemical synthesis / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D053978:Pentacyclic Triterpenes; D013055:Spectrophotometry, Infrared; D014315:Triterpenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D000094062:Betulinic Acid
D000998:Antiviral Agents; D002219:Carbamates; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D000094062:Betulinic Acid