Multilocus genotyping of Pneumocystis jirovecii in patients developing diverse forms of parasitism: implication for a wide human reservoir for the fungus.
Pneumocystis jirovecii ITS and DHPS genotypes were identified in 3 patient groups developing diverse forms of P. jirovecii infections: 13 patients with Pneumocystis pneumonia, 8 patients merely colonized by the fungus, and 19 immunocompetent infants with bronchiolitis developing mild P. jirovecii infection. Common P. jirovecii genotypes were found in the 3 patient groups, suggesting that common sources of P. jirovecii were involved in the fungus acquisition, and that transmission cycles of P. jirovecii infections in these patient groups are not independent. Parasitized patients, whatever the form of parasitism they present, may be part of a common reservoir for P. jirovecii.
Totet
Anne
A
Department of Parasitology, Mycology and Travel Medicine, University Hospital, University of Picardy, 80054 Amiens, France, EU. annetotet@yahoo.fr
Latouche
Sophie
S
Duwat
Hyacinthe
H
Magois
Eline
E
Lacube
Philippe
P
Pautard
Jean-Claude
JC
Schmit
Jean-Luc
JL
Jounieaux
Vincent
V
Roux
Patricia
P
Raccurt
Christian
C
Nevez
Gilles
G
D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002874:Chromosome Mapping; D004197:Disease Reservoirs; D005260:Female; D005602:France; D005798:Genes, Bacterial / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D045363:Pneumocystis carinii / Q000235:genetics* / Q000302:isolation & purification; D011020:Pneumonia, Pneumocystis / Q000382:microbiology* / Q000635:transmission