title: Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomography.
abstract: We present an algorithm to reconstruct chromosphere concentration images directly rather than following the traditional two-step process of reconstructing wavelength-dependent absorption coefficient images and then calculating chromosphere concentration images. This procedure imposes prior spectral information into the image reconstruction that results in a dramatic improvement in the image contrast-to-noise ratio of better than 100%. We demonstrate this improvement with simulations and a dynamic blood phantom experiment.
authors.affiliation: Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. angli@nmr.mgh.harvard.edu
authors.forename: Ang
authors.initials: A
authors.lastname: Li
authors.forename: Quan
authors.initials: Q
authors.lastname: Zhang
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Culver
authors.forename: Eric L
authors.initials: EL
authors.lastname: Miller
authors.forename: David A
authors.initials: DA
authors.lastname: Boas
mesh_terms: D000465:Algorithms; D000818:Animals; D016477:Artifacts; D004058:Diffusion; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009994:Osmolar Concentration; D010108:Oxyhemoglobins / Q000378:metabolism; D041622:Tomography, Optical
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin