title: Apolipoprotein E gene polymorphism in Indian patients with Alzheimer's disease and vascular dementia.
abstract: The association of apolipoprotein E (ApoE) gene polymorphism with Alzheimer's disease (AD) has been reported in several populations including one from a rural community in North India. However, the association of ApoE polymorphism with vascular dementia (VaD) is yet to be established in this population. In a case-control study involving 54 cases of dementia (29 AD and 25 VaD) and 76 age-matched healthy controls, the frequency of epsilon4 allele was significantly higher among cases of AD and VaD compared with controls (p < 0.001). The epsilon3epsilon3 (p < 0.05) and epsilon2epsilon3 (p < 0.001) genotypes were found to be protective. The odds of developing AD or VaD were 4.4 and 3.7 times higher, respectively, in the presence of even a single epsilon4 allele. Our results suggest that the increased risk of developing AD or VaD is similar among Asian Indians with ApoE epsilon4 compared with the Caucasian population.
authors.affiliation: Department of Biochemistry, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Kalpana
authors.initials: K
authors.lastname: Luthra
authors.forename: Manjari
authors.initials: M
authors.lastname: Tripathi
authors.forename: Rahul
authors.initials: R
authors.lastname: Grover
authors.forename: Manjari
authors.initials: M
authors.lastname: Dwivedi
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: A B
authors.initials: AB
authors.lastname: Dey
mesh_terms: D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D015140:Dementia, Vascular / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E