title: Antidepressants and public health in Iceland. Time series analysis of national data.
abstract: BACKGROUND
  Major depressive disorder is the second leading cause of disability-adjusted life-years in developed regions of the world and antidepressants are the third-ranking therapy class worldwide.
  
  
  OBJECTIVE
  To test the public health impact of the escalating sales of antidepressants.
  
  
  METHODS
  Nationwide data from Iceland are used as an example to study the effect of sales of antidepressants on suicide, disability, hospital admissions and out-patient visits.
  
  
  RESULTS
  Sales of antidepressants increased from 8.4 daily defined doses per 1000 inhabitants per day in 1975 to 72.7 in 2000, which is a user prevalence of 8.7% for the adult population. Suicide rates fluctuated during 1950-2000 but did not show any definite trend. Rates for out-patient visits increased slightly over the period 1989-2000 and admission rates increased even more. The prevalence of disability due to depressive and anxiety disorders has not decreased over the past 25 years.
  
  
  CONCLUSIONS
  The dramatic increase in the sales of antidepressants has not had any marked impact on the selected public health measures. Obviously, better treatment for depressive disorders is still needed in order to reduce the burden caused by them.
authors.affiliation: Faculty of Medicine, University of Iceland, Reykjavik, Iceland. tomashe@isholf.is
authors.forename: Tómas
authors.initials: T
authors.lastname: Helgason
authors.forename: Helgi
authors.initials: H
authors.lastname: Tómasson
authors.forename: Tómas
authors.initials: T
authors.lastname: Zoega
mesh_terms: D000293:Adolescent; D000328:Adult; D000553:Ambulatory Care / Q000706:statistics & numerical data; D000928:Antidepressive Agents / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000453:epidemiology; D003866:Depressive Disorder / Q000188:drug therapy* / Q000453:epidemiology; D006760:Hospitalization; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D010342:Patient Acceptance of Health Care / Q000706:statistics & numerical data; D011634:Public Health; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D013405:Suicide / Q000706:statistics & numerical data; D013997:Time Factors
chemical_list: D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D017367:Selective Serotonin Reuptake Inhibitors