title: A malignant peripheral nerve-sheath tumour responding to chemotherapy.
abstract: A malignant peripheral nerve-sheath tumour developed in the right S1 nerve root in a man aged 30 causing back pain and sciatica. CT and MRI revealed a destructive tumour of the sacrum invading the retroperitoneal space. The tumour was not resectable with an adequate margin. Chemotherapy, consisting of high-dose ifosfamide followed by a combination of vincristine, doxorubicin and cyclophosphamide, was given with success. Malignant peripheral nerve-sheath tumours are thought to respond weakly to chemotherapy, but the response in our patient was complete.
authors.affiliation: Department of Orthopaedic Surgery, Jikei University School of Medicine, National Cancer Centre Hospital, Tokyo, Japan.
authors.forename: F
authors.initials: F
authors.lastname: Masui
authors.forename: R
authors.initials: R
authors.lastname: Yokoyama
authors.forename: S
authors.initials: S
authors.lastname: Soshi
authors.forename: Y
authors.initials: Y
authors.lastname: Beppu
authors.forename: K
authors.initials: K
authors.lastname: Asanuma
authors.forename: K
authors.initials: K
authors.lastname: Fujii
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001416:Back Pain / Q000209:etiology; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008297:Male; D018317:Nerve Sheath Neoplasms / Q000150:complications / Q000188:drug therapy*; D012585:Sciatica / Q000209:etiology; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D007069:Ifosfamide