Atropisomers and near-atropisomers: achieving stereoselectivity by exploiting the conformational preferences of aromatic amides.
The conformational preferences of aromatic amides are remarkably easy to control with a high degree of selectivity. This article reviews the consequences of this unusual form of stereocontrol, which enables for example the asymmetric synthesis of atropisomers and the ability to achieve remote stereocontrol by conformational relay.
Clayden
Jonathan
J
Department of Chemistry, University of Manchester, Oxford Road, Manchester, UK M13 9PL. clayden@man.ac.uk