Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES.
Antiangiogenic activity has been identified in an aqueous EtOH extract of Rabdosia rubescens, a component of the dietary supplement PC SPES. Bioassay-guided fractionation using a novel in vitro human endothelial cell-based assay for angiogenesis afforded the diterpenoids ponicidin (1) and oridonin (2), with significant antiangiogenic activity at subcytotoxic concentrations, suggesting that these constituents may strongly contribute to the demonstrated clinical efficacy of PC SPES as a treatment for advanced prostate cancer.
Meade-Tollin
Linda C
LC
Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E. Valencia Road, Tucson, AZ 85706-6800, USA.
Wijeratne
E M Kithsiri
EM
Cooper
Deborah
D
Guild
Mischa
M
Jon
Edlyn
E
Fritz
Anne
A
Zhou
Guang-Xiong
GX
Whitesell
Luke
L
Liang
Jing-Yu
JY
Gunatilaka
A A Leslie
AA
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D002478:Cells, Cultured; D004224:Diterpenes / Q000494:pharmacology*; D045786:Diterpenes, Kaurane; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D006868:Hydrolysis; D020128:Inhibitory Concentration 50; D037602:Isodon / Q000737:chemistry*; D008297:Male; D015394:Molecular Structure; D011471:Prostatic Neoplasms / Q000188:drug therapy*
D020533:Angiogenesis Inhibitors; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045786:Diterpenes, Kaurane; D004365:Drugs, Chinese Herbal; C114209:herbal preparation PC-SPES; C011959:oridonin; C090365:ponicidin