New communesin derivatives from the fungus Penicillium sp. derived from the Mediterranean sponge Axinella verrucosa.
The ethyl acetate extract of Penicillium sp., derived from the Mediterranean sponge Axinella verrucosa, yielded the known compound communesin B (1) and its new congeners communesins C (2) and D (3), as well as the known compounds griseofulvin, dechlorogriseofulvin, and oxaline. All structures were unambiguously established by 1D and 2D NMR and MS data. In several bioassays performed on different leukemia cell lines, the communesins exhibited moderate antiproliferative activity.
Jadulco
Raquel
R
Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, Geb.26.23, D-40225 Düsseldorf, Germany.
Edrada
Ru Angelie
RA
Ebel
Rainer
R
Berg
Albrecht
A
Schaumann
Karsten
K
Wray
Victor
V
Steube
Klaus
K
Proksch
Peter
P
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006118:Griseofulvin / Q000302:isolation & purification; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007558:Italy; D008522:Mediterranean Sea; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D011161:Porifera; D013237:Stereoisomerism; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006576:Heterocyclic Compounds, 4 or More Rings; C483283:communesin B; C483284:communesin C; C483285:communesin D; D006118:Griseofulvin