title: Emergence in Klebsiella pneumoniae and Enterobacter cloacae clinical isolates of the VIM-4 metallo-beta-lactamase encoded by a conjugative plasmid.
abstract: Resistance to carbapenems is an emerging problem among gram-negative hospital pathogens. A transferable plasmid encoding the VIM-4 metallo-beta-lactamase was detected in isolates of Klebsiella pneumoniae and Enterobacter cloacae obtained from a single patient under carbapenem therapy. Thus, enterobacteria appear to increasingly contribute to the spread of VIM-type enzymes.
authors.affiliation: Laboratorio di Microbiologia, Ospedale di Circolo, and Università dell'Insubria, I-21100 Varese, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Luzzaro
authors.forename: Jean-Denis
authors.initials: JD
authors.lastname: Docquier
authors.forename: Céline
authors.initials: C
authors.lastname: Colinon
authors.forename: Andrea
authors.initials: A
authors.lastname: Endimiani
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Lombardi
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Amicosante
authors.forename: Gian Maria
authors.initials: GM
authors.lastname: Rossolini
authors.forename: Antonio
authors.initials: A
authors.lastname: Toniolo
mesh_terms: D000368:Aged; D003227:Conjugation, Genetic / Q000235:genetics*; D016972:Enterobacter cloacae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D004756:Enterobacteriaceae Infections / Q000382:microbiology; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D010957:Plasmids / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics*
chemical_list: D001618:beta-Lactamases; C482459:metallo-beta-lactamase VIM-4, Enterobacter cloacae; C482458:metallo-beta-lactamase VIM-4, Klebsiella pneumoniae