Periodontitis vaccine decreases local prostaglandin E2 levels in a primate model.
Interleukin-1beta, tumor necrosis factor alpha, prostaglandin E2 (PGE2), and Porphyromonas gingivalis-specific immunoglobulin G levels in gingival crevicular fluid were measured in primates immunized with a P. gingivalis vaccine followed by ligature-induced periodontitis. Only PGE2 levels were dramatically suppressed (P < 0.0001) in immunized animals versus controls. A significant correlation (P < 0.027) was also found between PGE2 levels and decreased bone loss scores. This study presents the first evidence of a potential mechanism involved in periodontitis vaccine-induced suppression of bone loss in a nonhuman primate model and offers insight into the role of PGE2 in periodontal destruction.
Roberts
Frank A
FA
Departments of Periodontics, University of Washington, Seattle, Washington 98195, USA. froberts@u.washington.edu
Houston
Laura S
LS
Lukehart
Sheila A
SA
Mancl
Lloyd A
LA
Persson
G Rutger
GR
Page
Roy C
RC
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D015232:Dinoprostone / Q000032:analysis* / Q000502:physiology; D004195:Disease Models, Animal; D005883:Gingival Crevicular Fluid / Q000737:chemistry; D007114:Immunization; D007375:Interleukin-1 / Q000032:analysis; D008252:Macaca fascicularis; D010518:Periodontitis / Q000517:prevention & control*; D016966:Porphyromonas gingivalis / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D001428:Bacterial Vaccines; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D015232:Dinoprostone