Quinacrine nonsurgical female sterilization in Baroda, India: 23 years of follow-up of 84 women.
Evaluate the long-term effectiveness and safety of transcervical insertion of quinacrine hydrochloride pellets for nonsurgical female sterilization (QS).



During the period June 1979 through January 1980, 84 women were admitted to a study at the Baroda Medical College and Hospital, Baroda, India. Our protocol called for three transcervical insertions of 252 mg of quinacrine hydrochloride to be deposited in the uterus of each patient. Follow-up was scheduled at 6, 12 and 48 months after the last administration.



These women were 25 to 39 years of age at the time of the QS procedure and now, 23 years later, have completed their reproductive years. There were 4 pregnancies subsequent to the completion of QS, all prior to their 4-year follow-up. Thus, the life-time failure rate for these women was 3.7%. Complaints were minor, especially when compared to surgical sterilization. There were no long-term effects suspected of being attributable to QS.



QS appears to be a reasonably effective method that is much safer than surgical sterilization.
Bhatt
R V
RV
Department of Obstetrics and Gynecology, B.D. Amin Hospital, Baroda, India. gsbt@satyam.net.in
D000328:Adult; D004343:Drug Implants; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007194:India; D008875:Middle Aged; D017060:Patient Satisfaction; D011247:Pregnancy; D011796:Quinacrine / Q000008:administration & dosage* / Q000009:adverse effects*; D012102:Reproductive Control Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D013246:Sterilization, Tubal; D013997:Time Factors; D014463:Ultrasonography; D014599:Uterus / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology
D004343:Drug Implants; D012102:Reproductive Control Agents; D011796:Quinacrine