Neural responses during interception of real and apparent circularly moving stimuli in motor cortex and area 7a.
We recorded the neuronal activity in the arm area of the motor cortex and parietal area 7a of two monkeys during interception of stimuli moving in real and apparent motion. The stimulus moved along a circular path with one of five speeds (180-540 degrees/s), and was intercepted at 6 o'clock by exerting a force pulse on a semi-isometric joystick which controlled a cursor on the screen. The real stimuli were shown in adjacent positions every 16 ms, whereas in the apparent motion situation five stimuli were flashed successively at the vertices of a regular pentagon. The results showed, first, that a group of neurons in both areas above responded not only during the interception but also during a NOGO task in which the same stimuli were presented in the absence of a motor response. This finding suggests these areas are involved in both the processing of the stimulus as well as in the preparation and production of the interception movement. In addition, a group of motor cortical cells responded during the interception task but not during a center --> out task, in which the monkeys produced similar force pulses towards eight stationary targets. This group of cells may be engaged in sensorimotor transformations more specific to the interception of real and apparent moving stimuli. Finally, a multiple regression analysis revealed that the time-varying neuronal activity in area 7a and motor cortex was related to various aspects of stimulus motion and hand force in both the real and apparent motion conditions, with stimulus-related activity prevailing in area 7a and hand-related activity prevailing in motor cortex. In addition, the neural activity was selectively associated with the stimulus angle during real motion, whereas it was tightly correlated to the time-to-contact in the apparent motion condition, particularly in the motor cortex. Overall, these observations indicate that neurons in motor cortex and area 7a are processing different parameters of the stimulus depending on the kind of stimulus motion, and that this information is used in a predictive fashion in motor cortex to trigger the interception movement.
Merchant
Hugo
H
Brain Sciences Center, Department of Veterans Affairs Medical Center, Minneapolis, MN 55417, USA.
Battaglia-Mayer
Alexandra
A
Georgopoulos
Apostolos P
AP
D000465:Algorithms; D000818:Animals; D001132:Arm / Q000294:innervation / Q000502:physiology; D003196:Computer Graphics; D004576:Electromyography; D004594:Electrophysiology; D005133:Eye Movements / Q000502:physiology; D005403:Fixation, Ocular / Q000502:physiology; D006225:Hand / Q000502:physiology; D008253:Macaca mulatta; D008297:Male; D009039:Motion Perception / Q000502:physiology*; D009044:Motor Cortex / Q000166:cytology* / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology; D010812:Physical Stimulation; D011597:Psychomotor Performance / Q000502:physiology; D012044:Regression Analysis