title: Bilateral anterior capsulotomy for refractory obsessive-compulsive disorders.
abstract: A prospective study on the effects of bilateral anterior capsulotomy in patients with refractory obsessive-compulsive disorder (OCD) is presented. A total of 18 procedures were performed in 15 patients. The mean duration of the OCDs was 18.1 +/- 5.6 years (range 11-26 years). The mean total Yale-Brown Scale (Y-BOCS) score was 29.67 and mean Global Assessment of Functioning was 43.61. The results throughout the follow-up period remained the same as at 1 month postoperatively. The observed mean recovery on the Y-BOCS was 33.2% (p = 0.017). 52.9% of the patients showed a 33% recovery, 29.4% of the cases showed a 50% recovery and 17% showed a 66% recovery. Global Assessment of Functioning recovered by 19% (p = 0.111). No cognitive deficit was disclosed by neuropsychological screening tests. Complications were observed in 3 cases, 1 with transitory hallucinations, 1 with a single epileptic seizure and 1 case who developed a progressive behavior disorder that became permanent. We conclude that bilateral anterior capsulotomy is a safe and effective procedure.
authors.affiliation: Department of Neurosurgery, Mutua de Terrassa Hospital, Terrassa, Spain. boliver@mutuaterrassa.es
authors.forename: Bartolomé
authors.initials: B
authors.lastname: Oliver
authors.forename: Josep
authors.initials: J
authors.lastname: Gascón
authors.forename: Alberto
authors.initials: A
authors.lastname: Aparicio
authors.forename: Emilio
authors.initials: E
authors.lastname: Ayats
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Rodriguez
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Maestro De León
authors.forename: Marcel
authors.initials: M
authors.lastname: García-Bach
authors.forename: Pere Anton
authors.initials: PA
authors.lastname: Soler
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D020772:Internal Capsule / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D009771:Obsessive-Compulsive Disorder / Q000601:surgery*; D011612:Psychosurgery; D013238:Stereotaxic Techniques; D016896:Treatment Outcome