title: Effects of moderate-fat (from monounsaturated fat) and low-fat weight-loss diets on the serum lipid profile in overweight and obese men and women.
abstract: BACKGROUND
  Little evidence of the effects of moderate-fat (from monounsaturated fat) weight-loss diets on risk factors for cardiovascular disease exists because low-fat diets are typically recommended. Previous studies in weight-stable persons showed that a moderate-fat diet results in a more favorable lipid and lipoprotein profile (ie, lower serum triacylglycerol and higher HDL cholesterol) than does a low-fat diet.
  
  
  OBJECTIVE
  We evaluated the effects of energy-controlled, low-fat and moderate-fat diets on changes in lipids and lipoproteins during weight loss and subsequent weight maintenance.
  
  
  METHODS
  We conducted a parallel-arm study design in overweight and obese [body mass index (in kg/m(2)): 29.8 +/- 2.4] healthy men and women (n = 53) assigned to consume a low-fat (18% of energy) or moderate-fat (33% of energy) diet for 6 wk to achieve weight loss, which was followed by 4 wk of weight maintenance. All foods were provided and body weight was monitored to ensure equal weight loss between groups.
  
  
  RESULTS
  The moderate-fat diet elicited favorable changes in the lipoprotein profile. Compared with baseline, HDL cholesterol was unchanged, whereas triacylglycerol and the ratios of total and non-HDL cholesterol to HDL cholesterol were lower at the end of the weight-maintenance period in the moderate-fat diet group. Despite similar weight loss, triacylglycerol rebounded, HDL cholesterol decreased, and the ratios of total and non-HDL cholesterol to HDL cholesterol did not change during the 10-wk interval in the low-fat diet group.
  
  
  CONCLUSIONS
  A moderate-fat weight-loss and weight-maintenance diet improves the cardiovascular disease risk profile on the basis of favorable changes in lipids and lipoproteins. There is merit in recommending a moderate-fat weight-loss diet.
authors.affiliation: Department of Exercise and Nutrition Sciences, The State University of New York at Buffalo, NY, USA.
authors.forename: Christine L
authors.initials: CL
authors.lastname: Pelkman
authors.forename: Valerie K
authors.initials: VK
authors.lastname: Fishell
authors.forename: Deborah H
authors.initials: DH
authors.lastname: Maddox
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Pearson
authors.forename: David T
authors.initials: DT
authors.lastname: Mauger
authors.forename: Penny M
authors.initials: PM
authors.lastname: Kris-Etherton
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D004038:Diet, Reducing; D004041:Dietary Fats / Q000008:administration & dosage* / Q000097:blood; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy*; D014280:Triglycerides / Q000097:blood; D015431:Weight Loss
chemical_list: D004041:Dietary Fats; D005229:Fatty Acids, Monounsaturated; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol