Therapeutic vaccines for substance dependence.
Immunotherapies are under development as a new approach to the treatment of substance dependence. The drugs of abuse currently being tested using this new approach are nicotine, cocaine, phencyclidine and methamphetamine. In laboratory animal models, a range of immunotherapies, including vaccines, monoclonal antibodies and catalytic antibodies, have been shown to reduce drug seeking. In human clinical trials, cocaine and nicotine vaccines have been shown to induce antibody titers while producing few side effects. Studies in humans determining how these vaccines interact in combination with their target drug are underway. Overall, immunotherapy offers a range of potential treatment options: drug treatment, as well as the treatment of overdose, prevention of brain or cardiac toxicity and fetal protection in pregnant drug abusers.
Haney
Margaret
M
College of Physicians and Surgeons of Columbia University and the New York State Psychiatric Institute, Department of Psychiatry, New York, NY 10032, USA. mh235@columbia.edu
Kosten
Thomas R
TR
D019969:Amphetamine-Related Disorders / Q000276:immunology / Q000517:prevention & control; D000818:Animals; D002986:Clinical Trials as Topic; D019970:Cocaine-Related Disorders / Q000276:immunology / Q000517:prevention & control; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D010623:Phencyclidine Abuse / Q000276:immunology / Q000517:prevention & control; D011247:Pregnancy; D019966:Substance-Related Disorders / Q000276:immunology* / Q000517:prevention & control*; D014029:Tobacco Use Disorder / Q000276:immunology / Q000517:prevention & control; D014612:Vaccines / Q000009:adverse effects / Q000276:immunology*
D014612:Vaccines