title: 5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors.
abstract: 5(S)-Fluoro-N6-(iminoethyl)-l-lysine (14), an analogue of the potent, selective induced nitric oxide synthase (iNOS) inhibitor iminoethyl-l-lysine (1), was synthesized and found to be a selective iNOS inhibitor.
authors.affiliation: Pfizer, 4901 Searle Parkway, Skokie, Illinois 60077, USA. eahallinan@comcast.net
authors.forename: E Ann
authors.initials: EA
authors.lastname: Hallinan
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Hagen
authors.forename: Arija
authors.initials: A
authors.lastname: Bergmanis
authors.forename: William M
authors.initials: WM
authors.lastname: Moore
authors.forename: Gina M
authors.initials: GM
authors.lastname: Jerome
authors.forename: Dale P
authors.initials: DP
authors.lastname: Spangler
authors.forename: Anna M
authors.initials: AM
authors.lastname: Stevens
authors.forename: Huey S
authors.initials: HS
authors.lastname: Shieh
authors.forename: Pamela T
authors.initials: PT
authors.lastname: Manning
authors.forename: Barnett S
authors.initials: BS
authors.lastname: Pitzele
mesh_terms: D018360:Crystallography, X-Ray; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000737:chemistry; D008239:Lysine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D052247:Nitric Oxide Synthase Type II
chemical_list: C483195:5-fluoro-N6-(iminoethyl)lysine; D007527:Isoenzymes; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; D008239:Lysine