TRK neurotrophin receptor-like proteins in the kidney of frog (Rana esculenta) and lizard (Podarcis sicula): an immunohistochemical study.
The present study investigates the occurrence of Trk-like neurotrophin receptor proteins in the lizard and frog kidney. In lizard rare TrkB-like immunoreactive cells in intermediate and distal tubules were found. TrkC-like immunoreactive cells were numerous in collecting tubules and became less numerous in collecting ducts. No TrkC-like immunoreactivity was detected in the ureteric duct. In the frog, we observed numerous TrkC-like immunoreactive cells in collecting tubules and ducts while they were scattered among negative epithelial cells in the wolffian duct. TrkB- and TrkA-like immunoreactivity was never found. Western blot analysis demonstrated that the frog and lizard kidney contains TrkC-like protein; TrkB-like protein was present only in the lizard kidney. These results demonstrate for the first time the occurrence of Trk-like proteins in the kidney of amphibians and reptiles, and aid in the assessment of the role of Trk receptor-like proteins in the kidney physiology of vertebrates.
De Girolamo
P
P
Dipartimento di Strutture, Funzioni e Tecnologie Biologiche, Università di Napoli "Federico II", Via F. Delpino 1, 80137 Naples, Italy. degirola@unina.it
Arcamone
N
N
Lucini
C
C
Simeoli
M Pia
MP
Castaldo
L
L
Gargiulo
G
G
D000818:Animals; D015153:Blotting, Western; D019084:Fluorescent Antibody Technique, Indirect; D007124:Immunoenzyme Techniques / Q000379:methods*; D007668:Kidney / Q000378:metabolism*; D008116:Lizards / Q000502:physiology*; D011893:Rana esculenta / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases / Q000145:classification / Q000378:metabolism*
D020794:Receptor Protein-Tyrosine Kinases