title: Taraxer-14-en-3beta-ol, an anti-inflammatory compound from Sterculia foetida L.
abstract: Taraxer-14-en-3beta-ol ( 1) was shown to be the active ingredient in the leaves of Sterculia foetida L. The alcohol 1, its acetate and ketone showed anti-inflammatory activity against TPA induced mouse ear oedema with inhibition ratios of 60.0, 58.57 and 40.57 at 0.5 mg/ear, respectively. The percentage inhibition of inflammation increased with dose for each compound.
authors.affiliation: Agharkar Research Institute, Pune, India. dgnpune@yahoo.co.in
authors.forename: D G
authors.initials: DG
authors.lastname: Naik
authors.forename: A M
authors.initials: AM
authors.lastname: Mujumdar
authors.forename: R J
authors.initials: RJ
authors.lastname: Waghole
authors.forename: A V
authors.initials: AV
authors.lastname: Misar
authors.forename: S W
authors.initials: SW
authors.lastname: Bligh
authors.forename: Alan
authors.initials: A
authors.lastname: Bashall
authors.forename: John
authors.initials: J
authors.lastname: Crowder
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice; D009828:Oleanolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D032361:Sterculia
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D009828:Oleanolic Acid; C005802:taraxerol