Microbial/enzymatic synthesis of chiral pharmaceutical intermediates.
Chirality is a key factor in the efficacy of many drugs; thus, the production of single enantiomers of drug intermediates has become increasingly important in the pharmaceutical industry. Chiral intermediates and fine chemicals are in high demand from the pharmaceutical and agrochemical industries for the preparation of bulk drug substances and agricultural products. There has been an increasing awareness of the enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivity. In this article, biocatalytic processes for the synthesis of chiral pharmaceutical intermediates are described.
Patel
Ramesh N
RN
Bristol-Myers Squibb, Process R&D, New Brunswick, NJ 08903, USA. ramesh.patel@bms.com
D000818:Animals; D001419:Bacteria / Q000737:chemistry / Q000201:enzymology*; D005658:Fungi / Q000737:chemistry / Q000201:enzymology*; D006571:Heterocyclic Compounds; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011355:Prodrugs / Q000737:chemistry*; D013237:Stereoisomerism
D006571:Heterocyclic Compounds; D004364:Pharmaceutical Preparations; D011355:Prodrugs