Dual-function ion channel/protein kinases: novel components of vertebrate magnesium regulatory mechanisms.
Although magnesium is the dominant divalent intracellular cation and is required for the function of diverse types of enzymes that participate in virtually every cellular process, the molecular mechanisms that regulate its homeostasis are poorly understood. Electrophysiologic and biochemical investigations of a novel dual-function ion channel/kinase protein have recently converged with the identification of the gene locus for an autosomal recessive form of inherited hypomagnesemia to provide new insight into vertebrate magnesium regulatory mechanisms.
Schmitz
Carsten
C
Department of Pediatrics, University of Washington and Children's Hospital and Regional Medical Center, Seattle, WA 98195, USA.
Perraud
Anne-Laure
AL
Fleig
Andrea
A
Scharenberg
Andrew M
AM
D000818:Animals; D001692:Biological Transport; D002412:Cations; D002413:Cations, Divalent; D004594:Electrophysiology; D006801:Humans; D007473:Ion Channels / Q000737:chemistry* / Q000502:physiology*; D008274:Magnesium / Q000737:chemistry; D008565:Membrane Proteins / Q000502:physiology*; D008954:Models, Biological; D011494:Protein Kinases / Q000737:chemistry* / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases; D050053:TRPM Cation Channels
D002412:Cations; D002413:Cations, Divalent; D007473:Ion Channels; D008565:Membrane Proteins; D050053:TRPM Cation Channels; C459082:TRPM6 protein, human; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; C486583:TRPM7 protein, human; D008274:Magnesium