title: Chronic experimental myocardial infarction produces antinatriuresis by a renal nerve-dependent mechanism.
abstract: The present study focused on the role of sympathetic renal nerve activity, in mediating congestive heart failure-induced sodium retention following experimental chronic myocardial infarction. Groups of male Wistar rats (240-260 g) were studied: sham-operated coronary ligation (CON3W, N = 11), coronary ligation and sham-operated renal denervation (INF3W, N = 19), 3 weeks of coronary ligation and sympathetic renal nerve denervation (INF3WDX, N = 6), sham-operated coronary ligation (N = 7), and 16 weeks of coronary ligation (INF16W, N = 7). An acute experimental protocol was used in which the volume overload (VO; 5% of body weight) was applied for 30 min after the equilibration period of continuous iv infusion of saline. Compared to control levels, VO produced an increase (P < 0.01, ANOVA) in urine flow rate (UFR; 570%) and urinary sodium excretion (USE; 1117%) in CON3W. VO induced a smaller increase (P < 0.01) in USE (684%) in INF3W. A similar response was also observed in INF16W. In INF3WDX, VO produced an immediate and large increase (P < 0.01) in UFR (547%) and USE (1211%). Similarly, in INF3W VO increased (P < 0.01) UFR (394%) and USE (894%). Compared with INF3W, VO induced a higher (P < 0.01) USE in INF3WDX, whose values were similar to those for CON3W. These results suggest that renal sympathetic activity may be involved in sodium retention induced by congestive heart failure. This premise is supported by the observation that in bilaterally renal denervated INF3WDX rats myocardial infarction was unable to reduce volume expansion-induced natriuresis. However, the mechanism involved in urinary volume regulation seems to be insensitive to the factors that alter natriuresis.
authors.affiliation: Departamento de Ciências Fisiológicas, Centro Biomédico, Universidade Federal do Espírito Santo, Av. Marechal Campos 1468, 29040-090 Vitória, ES, Brazil.
authors.forename: D R B
authors.initials: DR
authors.lastname: Souza
authors.forename: J G
authors.initials: JG
authors.lastname: Mill
authors.forename: A M
authors.initials: AM
authors.lastname: Cabral
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D006333:Heart Failure / Q000150:complications; D006439:Hemodynamics; D007668:Kidney / Q000294:innervation* / Q000503:physiopathology; D008297:Male; D009203:Myocardial Infarction / Q000209:etiology / Q000503:physiopathology*; D009318:Natriuresis; D051381:Rats; D017208:Rats, Wistar; D013564:Sympathetic Nervous System / Q000503:physiopathology*