title: Topical 0.1% tacrolimus for the treatment of discoid lupus erythematosus and pemphigus erythematosus in dogs.
abstract: Topical 0.1% tacrolimus was used for treatment of localized lesions associated with 10 cases of discoid lupus erythematosus (DLE) and two cases of pemphigus erythematosus (PE) either as a sole therapy (n=2) or as an adjunctive treatment (n=10). Eight of 10 dogs with DLE and both dogs with PE were improved following 8 weeks of topical application. In six of the eight dogs that improved, other medications were discontinued. No adverse effects in clinical or laboratory parameters were noted throughout the study.
authors.affiliation: Animal Dermatology Clinic, Tustin, California 92780, USA.
authors.forename: Joel D
authors.initials: JD
authors.lastname: Griffies
authors.forename: Colleen L
authors.initials: CL
authors.lastname: Mendelsohn
authors.forename: Wayne S
authors.initials: WS
authors.lastname: Rosenkrantz
authors.forename: Rusty
authors.initials: R
authors.lastname: Muse
authors.forename: Mona J
authors.initials: MJ
authors.lastname: Boord
authors.forename: Craig E
authors.initials: CE
authors.lastname: Griffin
mesh_terms: D000287:Administration, Topical; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D005260:Female; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008179:Lupus Erythematosus, Discoid / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male; D010392:Pemphigus / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D016559:Tacrolimus / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D016559:Tacrolimus