Age-related vascular changes in the epiphysis, physis, and metaphysis: normal findings on gadolinium-enhanced MRI of piglets.
OBJECTIVE
We sought to study the normal enhancement patterns seen on MRIs of the epiphysis, physis, and metaphysis and age-related vascular changes in piglets using gadoteridol, a nonionic gadolinium chelate.


METHODS
We quantitatively and qualitatively analyzed the normal changes on sequential T1-weighted images after the IV administration of gadoteridol. In an investigation approved by the research animal care committee at our hospital, we studied the proximal and distal femurs of 26 piglets 1-6 weeks old and correlated the enhanced images with findings on intermediate-weighted, T2-weighted, and gradient-recalled echo images and at histologic examination.


RESULTS
We observed early enhancement of the epiphyseal vascular canals, the main physis, the physis of the secondary ossification center, and a metaphyseal band adjacent to the physis. Enhancement of the epiphyseal and metaphyseal marrow and of the epiphyseal cartilage was slower. In the epiphyseal cartilage, we saw three phases of enhancement: vascular, canalicular, and cartilaginous. As the piglets matured, enhancement of the epiphyseal cartilage decreased, and the epiphyseal vascular canals were less conspicuous. Physeal enhancement was greatest during the first week of life, declined at 3 weeks, and subsequently increased again as the physis came to lie adjacent to a larger segment of the epiphyseal ossification center.


CONCLUSIONS
Gadoteridol-enhanced MRIs showed multiple cartilaginous and vascular structures of the growing skeleton. With maturity and progressive epiphyseal ossification, epiphyseal cartilage enhancement decreased, and physeal cartilage enhancement increased.
Jaramillo
Diego
D
Department of Radiology, Harvard Medical School and Massachusetts General Hospital, 32 Fruit St, Boston, MA 02114, USA.
Villegas-Medina
Olga L
OL
Doty
David K
DK
Rivas
Roberto
R
Strife
Katherine
K
Dwek
Jerry R
JR
Mulkern
Robert V
RV
Shapiro
Frederic
F
D000375:Aging / Q000473:pathology*; D000818:Animals; D001808:Blood Vessels / Q000254:growth & development / Q000473:pathology; D001846:Bone Development; D003287:Contrast Media; D018483:Diaphyses / Q000098:blood supply* / Q000254:growth & development / Q000473:pathology; D005269:Femur / Q000098:blood supply / Q000254:growth & development / Q000473:pathology; D005682:Gadolinium; D006132:Growth Plate / Q000098:blood supply* / Q000254:growth & development / Q000473:pathology; D006571:Heterocyclic Compounds; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds; D012016:Reference Values; D013552:Swine
D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C062402:gadoteridol; D005682:Gadolinium