Ap-1 targets in the brain.
Activator protein-1 (AP-1) is a transcription factor involved in many aspects of the brain physiology and pathophysiology. In spite of strong engagement in a transcriptional regulation of the brain gene expression, only a few, if any, downstream AP-1 targets have unequivocally been identified so far. In the review we discuss only the best characterized AP-1 target genes in the brain, and we highlight the shortages of our understanding of AP-1 action in the central nervous system as well as indicate what could be done to ameliorate the situation.
Rylski
Marcin
M
Laboratory of Molecular Neurobiology, The Nencki Institute, 02-093 Warsaw, Pasteura 3, Poland. mylski@hotmail.com
Kaczmarek
Leszek
L
D001921:Brain / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D018808:Transcription Factor AP-1 / Q000502:physiology*
D018808:Transcription Factor AP-1