Mechanisms of genomic instability in human cancer: insights from studies with human papillomavirus oncoproteins.
Genomic instability is a hallmark of most human cancers including high-risk human papillomavirus (HPV)-associated anogenital neoplasia. The two HPV-encoded oncoproteins, E6 and E7, can independently induce chromosomal abnormalities. We summarize the current state of knowledge concerning HPV-induced genomic instability and discuss its significance in the context of human carcinogenesis.
Duensing
Stefan
S
Molecular Virology Program, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA 15213, USA. duensing@pitt.edu
Münger
Karl
K
D002453:Cell Cycle / Q000502:physiology; D002869:Chromosome Aberrations; D004249:DNA Damage; D005260:Female; D042822:Genomic Instability; D006801:Humans; D008938:Mitosis / Q000502:physiology; D009856:Oncogene Proteins, Viral / Q000235:genetics*; D027383:Papillomaviridae / Q000235:genetics* / Q000378:metabolism; D050725:Papillomavirus E7 Proteins; D030361:Papillomavirus Infections / Q000235:genetics* / Q000821:virology; D012097:Repressor Proteins; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000821:virology
C068651:E6 protein, Human papillomavirus type 16; D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; D012097:Repressor Proteins; C059731:oncogene protein E7, Human papillomavirus type 16