Comparison of survival and other complications after heart transplantation in patients taking amiodarone before surgery versus those not taking amiodarone.
Concern exists regarding preoperative amiodarone use and complications occurring after heart transplantation (HT). During a 10-year period of performing HT, we found that patients treated with amiodarone before undergoing HT had decreased overall survival, required longer periods of ventilatory support, and were at increased risk for significant bleeding complications. These findings raise further concern about the use of amiodarone treatment in patients with heart failure before undergoing HT.
Blomberg
Patrick J
PJ
Division of Cardiology, Tufts University Medical School, Tufts-New England Medical Center, Boston, Massachusetts, USA.
Feingold
Andrew D
AD
Denofrio
David
D
Rand
William
W
Konstam
Marvin A
MA
Estes
N A Mark
NA
Link
Mark S
MS
D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D005260:Female; D006333:Heart Failure / Q000401:mortality* / Q000628:therapy*; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D015996:Survival Rate; D014665:Vasodilator Agents / Q000009:adverse effects*
D014665:Vasodilator Agents; D000638:Amiodarone