title: Pharmacokinetics and biodistribution of [111In]-avidin and [99mTc]-biotin-liposomes injected in the pleural space for the targeting of mediastinal nodes.
abstract: Pharmacokinetics and mediastinal node uptake of [111In]-avidin and [99mTc]-biotin-liposomes following either intrapleural (pleural) or intraperitoneal (ip) injection were determined using scintigraphic imaging. Biodistribution results of [111In]-avidin at 44 h showed 3.3% uptake in mediastinal nodes by pleural injection vs 1.3% with ip injection. Mediastinal node accumulation with [99mTc]-biotin-liposomes was not different between injections (0.6% ip vs 0.5% pleural). This study demonstrates the potential of the pleural route as a technique for mediastinal node targeting using the avidin/biotin-liposome system.
authors.affiliation: Department of Radiology, Mail Code 7800, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229-3900, USA.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Medina
authors.forename: Robert
authors.initials: R
authors.lastname: Klipper
authors.forename: William T
authors.initials: WT
authors.lastname: Phillips
authors.forename: Beth
authors.initials: B
authors.lastname: Goins
mesh_terms: D000818:Animals; D001360:Avidin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001710:Biotin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005240:Feasibility Studies; D007205:Indium Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics; D007267:Injections; D008081:Liposomes / Q000493:pharmacokinetics*; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging*; D008657:Metabolic Clearance Rate; D009928:Organ Specificity; D035422:Pleural Cavity / Q000000981:diagnostic imaging / Q000378:metabolism*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013667:Technetium / Q000008:administration & dosage / Q000493:pharmacokinetics; D014018:Tissue Distribution
chemical_list: D007205:Indium Radioisotopes; D008081:Liposomes; D019275:Radiopharmaceuticals; D001360:Avidin; D001710:Biotin; D013667:Technetium