Valproic acid has no effect on pain in polyneuropathy: a randomized, controlled trial.
The aim of this randomized, double-blind, placebo-controlled cross-over study was to test whether valproic acid relieves painful polyneuropathy. Thirty-one patients completed two treatment phases of 4 weeks' duration with valproic acid (1,500 mg daily) and placebo. There was no significant difference between valproic acid and placebo in the rating of total pain (median, 5 in the valproic acid period vs 6 in the placebo period; p = 0.24) or in individual pain ratings.
Otto
Marit
M
Department of Neurology, Odense University Hospital, Denmark. maritotto@dadlnet.dk
Bach
Flemming W
FW
Jensen
Troels S
TS
Sindrup
Søren H
SH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000188:drug therapy* / Q000209:etiology; D010147:Pain Measurement; D011115:Polyneuropathies / Q000150:complications / Q000188:drug therapy*; D017211:Treatment Failure; D014635:Valproic Acid / Q000627:therapeutic use*
D014635:Valproic Acid