Mac1 positive cells are required for enhancement of splenocytes proliferation caused by bisphenol a.
We examined the effects of bisphenol A (BPA) on immune cells and it was shown that BPA upregulated the proliferation of murine splenocytes stimulated with Concanavalin A (ConA). The upregulating effects of BPA were removed with depleting Mac1+ cells from the splenocytes. This study provides evidence for the first time that Mac1+ cells were required for enhancement of splenocytes proliferation caused by bisphenol A.
Goto
Masao
M
National Food Research Institute, Kannondai, Ibaraki, Japan. masaogot@nfri.affrc.go.jp
Ono
Hiroshi
H
Takano-Ishikawa
Yuko
Y
Shinmoto
Hiroshi
H
Yoshida
Mitsuru
M
D000818:Animals; D001559:Benzhydryl Compounds; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D016177:Macrophage-1 Antigen / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D010636:Phenols / Q000276:immunology / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology* / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects; D018800:Thy-1 Antigens / Q000378:metabolism; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D003208:Concanavalin A; D016177:Macrophage-1 Antigen; D010636:Phenols; D018800:Thy-1 Antigens; C006780:bisphenol A; D000098826:Bisphenol A Compounds