Atherosclerosis in type 2 diabetes mellitus: the role of insulin resistance.
Type 2 diabetes mellitus is associated with a marked increase in the risk of atherosclerotic diseases, including coronary heart disease, peripheral arterial disease, and cerebrovascular disease. Insulin resistance is a key factor in the pathogenesis of type 2 diabetes mellitus. Insulin resistance and its attendant metabolic abnormalities may cause much of the increased cardiovascular risk of type 2 diabetes mellitus. Among the abnormalities associated with insulin resistance are dyslipidemia, hypertension, systemic inflammation, and a prothrombotic state. This review discusses the role that each of these disorders plays in the cardiovascular risk of type 2 diabetes mellitus.
Watson
Karol E
KE
Division of Cardiology, The David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095-1679, USA. kwatson@mednet.ucla.edu
Peters Harmel
Anne L
AL
Matson
Gary
G
D003324:Coronary Artery Disease / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology*; D003328:Coronary Thrombosis / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D006973:Hypertension / Q000453:epidemiology / Q000378:metabolism / Q000503:physiopathology; D007333:Insulin Resistance / Q000502:physiology; D012307:Risk Factors