title: Hepatoprotection by 3-bromo-6-(4-chlorophenyl)-4-methylthio-2H-pyran-2-one against experimentally induced liver injury in rats.
abstract: Hepatoprotective activity of 3-bromo-6-(4-chlorophenyl)-4-methylthio-2H-pyran-2-one, an isostere of dimethyl ricinine, was evaluated in adult male albino rats intoxicated with carbon tetrachloride, paracetamol or thioacetamide. The test compound showed significant hepatoprotection at 6.0 mg kg(-1) body mass daily dose, given to the rats for seven consecutive days. The carbon tetrachloride, paracetamol and thioacetamide were given, respectively, on days 3, 5, and 7, on day 6 and on day 6 post treatment with the test compound. The protective effect was evident in a battery of serum and liver biochemical parameters related to hepatotoxicity.
authors.affiliation: Division of Biochemistry, Central Drug Research Institute, Lucknow--226001, India.
authors.forename: Brajendra Kumar
authors.initials: BK
authors.lastname: Tripathi
authors.forename: Savita
authors.initials: S
authors.lastname: Srivastava
authors.forename: Ravi
authors.initials: R
authors.lastname: Rastogi
authors.forename: Deepak
authors.initials: D
authors.lastname: Raina
authors.forename: Vishnu Ji
authors.initials: VJ
authors.lastname: Ram
authors.forename: Arvind Kumar
authors.initials: AK
authors.lastname: Srivastava
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D018712:Analgesics, Non-Narcotic / Q000633:toxicity*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control*; D002273:Carcinogens / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D002784:Cholesterol / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D006846:Hydrocarbons, Halogenated / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008111:Liver Function Tests; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D014176:Protein Biosynthesis; D011753:Pyrones / Q000627:therapeutic use*; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013853:Thioacetamide / Q000633:toxicity*
chemical_list: C482300:3-bromo-6-(4-chlorophenyl)-4-methylthio-2H-pyran-2-one; D018712:Analgesics, Non-Narcotic; D002273:Carcinogens; D006846:Hydrocarbons, Halogenated; D008112:Liver Glycogen; D011753:Pyrones; D013853:Thioacetamide; D000082:Acetaminophen; D012313:RNA; D004247:DNA; D002784:Cholesterol