Possible association between Cys311Ser polymorphism of paraoxonase 2 gene and late-onset Alzheimer's disease in Chinese.
The common polymorphism at codon 311 (C311S) of paraoxonase 2 gene (PON2) was investigated in 165 patients with sporadic late-onset Alzheimer's disease (LOAD) and 174 controls in Chinese. The PON2*C allele frequency was significantly increased in the patients as compared with controls. However, no significant difference was observed after stratification of apolipoprotein E (ApoE) epsilon4 allele. These results suggested that the PON2 polymorphism might be a risk factor for LOAD independent of ApoE epsilon4 status in Chinese.
Shi
Jiajun
J
Key Laboratory of Biotherapy of Human Diseases, Department of Medical Genetics, West China Hospital and Division of Human Morbid Genomics, Ministry of Education, Sichuan University, Chengdu, 610041, China. szzhang@mcwcums.com
Zhang
Sizhong
S
Tang
Mouni
M
Liu
Xiehe
X
Li
Tao
T
Han
Haiying
H
Wang
Yingcheng
Y
Guo
Yangbo
Y
Zhao
Jinghua
J
Li
Hai
H
Ma
Cui
C
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D043303:Aryldialkylphosphatase / Q000235:genetics* / Q000378:metabolism; D044466:Asian People / Q000235:genetics*; D016009:Chi-Square Distribution; D003545:Cysteine / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D012694:Serine / Q000235:genetics
D001057:Apolipoproteins E; D012694:Serine; D043303:Aryldialkylphosphatase; C468411:PON2 protein, human; D003545:Cysteine