Establishment of a new animal model of metabolic syndrome: SHRSP fatty (fa/fa) rats.
1. We established a new animal model of metabolic syndrome, SHRSP fatty (fa/fa) rats, by crossing stroke-prone spontaneously hypertensive rats of the Izumo strain (SHRSP/Izm) to Zucker fatty (ZF) (fa/fa) rats. 2. The SHRSP fatty (fa/fa) rats have a missense mutation of the leptin receptor gene and plasma leptin concentrations are augmented. The SHRSP fatty (fa/fa) rats develop obesity and hypertension simultaneously. 3. Plasma metabolic parameters, including glucose, insulin and total cholesterol and triglyceride levels, were markedly elevated in SHRSP fatty (fa/fa) rats compared with SHRSP/Izm rats. Plasma triglyceride concentrations in SHRSP fatty (fa/fa) rats were significantly elevated compared with those in ZF (fa/fa) rats. The weight of adipose tissues in SHRSP fatty (fa/fa) rats was greater than that of SHRSP/Izm rats. The phenotype of SHRSP fatty (fa/fa) rats is similar to that of human metabolic syndrome.
Hiraoka-Yamamoto
Junko
J
Frontier Health Science Forum, Mukogawa Women's University, 11-68 Koshien Kyuban-cho, Nishinomiya City, Hyogo 663-8179, Japan. junko@mwu.mukogawa-u.ac.jp
Nara
Yasuo
Y
Yasui
Naomi
N
Onobayashi
Yuko
Y
Tsuchikura
Satoru
S
Ikeda
Katsumi
K
D000273:Adipose Tissue / Q000033:anatomy & histology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002318:Cardiovascular Diseases / Q000209:etiology / Q000235:genetics; D004195:Disease Models, Animal; D006439:Hemodynamics / Q000235:genetics / Q000502:physiology; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D024821:Metabolic Syndrome / Q000235:genetics / Q000503:physiopathology*; D009154:Mutation / Q000502:physiology; D009765:Obesity / Q000235:genetics; D010641:Phenotype; D051381:Rats; D011918:Rats, Inbred SHR; D011924:Rats, Zucker; D011956:Receptors, Cell Surface / Q000235:genetics; D054411:Receptors, Leptin
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin