Adiponectin is independently associated with glycosylated haemoglobin.
BACKGROUND
In humans, adiponectin has been demonstrated to circulate in inverse proportion to the degree of insulin resistance.


OBJECTIVE
To investigate the association between adiponectin and glycosylated haemoglobin (HbA1c) in a population-based study.


METHODS
Two hundred and ninety-seven individuals aged 30-75 years were enrolled in a cross-sectional study. They included patients with type 2 (non-insulin-dependent) diabetes mellitus and stable, good metabolic control (n=32) and individuals with glucose intolerance (n=54). Adiponectin was measured using a sandwich enzyme-linked immunosorbent assay (intra-assay and interassay coefficients of variation 3.3 and 7.4% respectively).


RESULTS
Adiponectin correlated with age (r=0.161; P=0.006), body mass index (r=-0.197; P=0.001), diastolic blood pressure (r=-0.181; P=0.005), fasting glucose and HbA1c (r=-0.251 and r=-0.22 respectively; P<0.0001), high-density lipoprotein cholesterol (r=0.442; P<0.001) and serum triglycerides (r=-362; P<0.001). In multiple regression analysis, sex, age, fasting and post-load glucose, and adiponectin independently contributed to 40% of the variance in HbA1c. Among individuals with normal glucose tolerance, fasting glucose (P=0.0033), post-load glucose (P=0.0015), age (P=0.001) and adiponectin (P=0.0083) independently contributed to 21% of the variance in HbA1c.


CONCLUSIONS
Adiponectin is significantly associated with altered glucose metabolism and independently contributes to the variance of HbA1c in a population-based manner.
Fernández-Real
José Manuel
JM
Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain. uden.jmfernandezreal@htrueta.scs.es
Botas-Cervero
Patricia
P
López-Bermano
Abel
A
Casamitjana
Roser
R
Funahashi
Tohru
T
Delgado
Elías
E
Kihara
Shinji
S
Ricart
Wifredo
W
D052242:Adiponectin; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D006442:Glycated Hemoglobin / Q000031:analogs & derivatives* / Q000032:analysis*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000032:analysis*; D013223:Statistics as Topic
D052242:Adiponectin; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; C025617:glucosylated hemoglobin A