title: TRK neurotrophin receptor-like proteins in the kidney of frog (Rana esculenta) and lizard (Podarcis sicula): an immunohistochemical study.
abstract: The present study investigates the occurrence of Trk-like neurotrophin receptor proteins in the lizard and frog kidney. In lizard rare TrkB-like immunoreactive cells in intermediate and distal tubules were found. TrkC-like immunoreactive cells were numerous in collecting tubules and became less numerous in collecting ducts. No TrkC-like immunoreactivity was detected in the ureteric duct. In the frog, we observed numerous TrkC-like immunoreactive cells in collecting tubules and ducts while they were scattered among negative epithelial cells in the wolffian duct. TrkB- and TrkA-like immunoreactivity was never found. Western blot analysis demonstrated that the frog and lizard kidney contains TrkC-like protein; TrkB-like protein was present only in the lizard kidney. These results demonstrate for the first time the occurrence of Trk-like proteins in the kidney of amphibians and reptiles, and aid in the assessment of the role of Trk receptor-like proteins in the kidney physiology of vertebrates.
authors.affiliation: Dipartimento di Strutture, Funzioni e Tecnologie Biologiche, Università di Napoli "Federico II", Via F. Delpino 1, 80137 Naples, Italy. degirola@unina.it
authors.forename: P
authors.initials: P
authors.lastname: De Girolamo
authors.forename: N
authors.initials: N
authors.lastname: Arcamone
authors.forename: C
authors.initials: C
authors.lastname: Lucini
authors.forename: M Pia
authors.initials: MP
authors.lastname: Simeoli
authors.forename: L
authors.initials: L
authors.lastname: Castaldo
authors.forename: G
authors.initials: G
authors.lastname: Gargiulo
mesh_terms: D000818:Animals; D015153:Blotting, Western; D019084:Fluorescent Antibody Technique, Indirect; D007124:Immunoenzyme Techniques / Q000379:methods*; D007668:Kidney / Q000378:metabolism*; D008116:Lizards / Q000502:physiology*; D011893:Rana esculenta / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases / Q000145:classification / Q000378:metabolism*
chemical_list: D020794:Receptor Protein-Tyrosine Kinases