title: Application of capillary electrophoresis with different sample stacking strategies for the determination of a group of nonsteroidal anti-inflammatory drugs in the low microg x L(-1) concentration range.
abstract: Several on-column sample preconcentration modes--large-volume sample stacking using the EOF pump (LVSEP), LVSEP with anion-selective exhaustive injection (LVSEP-ASEI) and field-amplified sample injection with sample matrix removal using the electroosmotic flow (EOF) pump (FAEP)--were used to analyze some nonsteroidal anti-inflammatory drugs (NSAIDs) by capillary electrophoresis, and then compared. Methanol was the background electrolyte solvent to suppress the EOF. The effect of the type and length of the solvent plug, and the sample injection time were investigated in FAEP to determine the conditions that provided the best response. LVSEP, LVSEP-ASEI, and FAEP improved the sensitivity of the peak area by 100-, 1200-, and 1800-fold, respectively. The methodology developed, in combination with solid-phase extraction (SPE), was applied to the analysis of water samples.
authors.affiliation: Departament de Química Analítica i Química Orgànica, Universitat Rovira i Virgili, Tarragona, Spain.
authors.forename: Alba
authors.initials: A
authors.lastname: Macià
authors.forename: Francesc
authors.initials: F
authors.lastname: Borrull
authors.forename: Carme
authors.initials: C
authors.lastname: Aguilar
authors.forename: Marta
authors.initials: M
authors.lastname: Calull
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D004008:Diclofenac / Q000032:analysis; D019075:Electrophoresis, Capillary / Q000379:methods* / Q000592:standards; D005279:Fenoprofen / Q000032:analysis; D007052:Ibuprofen / Q000032:analysis; D007660:Ketoprofen / Q000032:analysis; D009288:Naproxen / Q000032:analysis; D014867:Water / Q000032:analysis
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D014867:Water; D004008:Diclofenac; D009288:Naproxen; D007660:Ketoprofen; D005279:Fenoprofen; D007052:Ibuprofen