title: Age-related changes in lymphocyte development and function.
abstract: The effects of aging on the immune system are widespread and extend from hematopoietic stem cells and lymphoid progenitors in the bone marrow and thymus to mature lymphocytes in secondary lymphoid organs. These changes combine to result in a diminution of immune responsiveness in the elderly. This review aims to provide an overview of age-related changes in lymphocyte development and function and discusses current controversies in the field of aging research.
authors.affiliation: Sidney Kimmel Cancer Center, San Diego, California 92121, USA.
authors.forename: Phyllis Jean
authors.initials: PJ
authors.lastname: Linton
authors.forename: Kenneth
authors.initials: K
authors.lastname: Dorshkind
mesh_terms: D000375:Aging / Q000276:immunology* / Q000473:pathology; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology; D002454:Cell Differentiation; D006410:Hematopoiesis / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D051379:Mice; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology