Type III secretion: a virulence factor delivery system essential for the pathogenicity of Burkholderia mallei.
By creating mutations in the Burkholderia mallei ATCC 23344 animal pathogen-like type III secretion system (TTSS), this study analyzes the correlation between type III secretion and the pathogenicity of ATCC 23344 in vivo. Mutagenesis demonstrated that a functional TTSS was required for the full pathogenicity of ATCC 23344 in the BALB/c mouse and Syrian hamster models of infection. However, vaccination with each mutant failed to elicit a protective immunity against challenge with wild-type ATCC 23344.
Ulrich
Ricky L
RL
Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702-5011, USA.
DeShazer
David
D
D000818:Animals; D042726:Burkholderia mallei / Q000276:immunology / Q000378:metabolism / Q000472:pathogenicity*; D006224:Cricetinae; D005260:Female; D008647:Mesocricetus; D051379:Mice; D008807:Mice, Inbred BALB C; D014611:Vaccination; D037521:Virulence Factors / Q000378:metabolism*
D037521:Virulence Factors