Synthesis of vitamin D in skin after burns.
Severe burn injury is associated with vitamin D deficiency, low bone turnover, and abnormalities in calcium homoeostasis. Patients do not routinely receive vitamin D supplementation and sun exposure is currently not controlled. By analysis of skin biopsy samples for vitamin D3 precursors after exposure to ultraviolet B light we found that the conversion of 7-dehydrocholesterol to previtamin D3 was reduced in children a mean of 14 months after the burn. Low serum 25-hydroxyvitamin D concentrations were also found. We conclude that vitamin D supplementation is necessary after burn injury.
Klein
Gordon L
GL
Department of Paediatrics, University of Texas Medical Branch, Galveston TX 77555-0352, USA. gklein@utmb.edu
Chen
Tai C
TC
Holick
Michael F
MF
Langman
Craig B
CB
Price
Heather
H
Celis
Mario M
MM
Herndon
David N
DN
D000293:Adolescent; D002056:Burns / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D002762:Cholecalciferol / Q000031:analogs & derivatives* / Q000378:metabolism; D019587:Dietary Supplements; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012867:Skin / Q000293:injuries* / Q000378:metabolism*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000096:biosynthesis* / Q000378:metabolism / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000517:prevention & control
D014807:Vitamin D; D002762:Cholecalciferol; C104450:25-hydroxyvitamin D; C025168:previtamin D(3)