Novel and efficient synthesis of difficult sequence-containing peptides through O-N intramolecular acyl migration reaction of O-acyl isopeptides.
A novel and efficient method for the synthesis of difficult sequence-containing peptides has been developed based on the synthesis of O-acyl isopeptides followed by an O-N intramolecular acyl migration reaction, resulting in a remarkable improvement of the yields.
Sohma
Youhei
Y
Department of Medicinal Chemistry, Center for Frontier Research in Medicinal Science, Kyoto Pharmaceutical University, Yamashina-Ku, Kyoto 607-8412, Japan.
Sasaki
Masato
M
Hayashi
Yoshio
Y
Kimura
Tooru
T
Kiso
Yoshiaki
Y
D000215:Acylation; D007202:Indicators and Reagents; D010455:Peptides / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D010455:Peptides