Fluorinated dihydroquinolines as potent n-NOS inhibitors.
Fluorinated dihydroquinolines showed reduced basicity of the amidine function. Their syntheses and potencies as neuronal nitric oxide synthase (n-NOS) inhibitors are reported.
Jaroch
Stefan
S
Medicinal Chemistry, Corporate Research, Research Center Europe, Schering AG, D-13342-Berlin, Germany. stefan.jaroch@schering.de
Rehwinkel
Hartmut
H
Hölscher
Peter
P
Sülzle
Detlev
D
Burton
Gerardine
G
Hillmann
Margrit
M
McDonald
Fiona M
FM
Miklautz
Heribert
H
D000578:Amidines / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D005461:Fluorine / Q000737:chemistry*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052248:Nitric Oxide Synthase Type I; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000578:Amidines; D004791:Enzyme Inhibitors; D011804:Quinolines; D005461:Fluorine; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I