Screening of Brazilian basidiomycetes for antimicrobial activity.
A total of 103 isolates of basidiomycetes, representing 84 species from different Brazilian ecosystems, were evaluated for their antifungal and antibacterial activity in a panel of pathogenic and non-pathogenic microorganisms. Tissue plugs of the fruiting bodies were cultivated in liquid media and the whole culture extracted with ethyl acetate. Crude extracts from Agaricus cf. nigrecentulus, Agrocybe perfecta, Climacodon pulcherrimus, Gloeoporus thelephoroides, Hexagonia hydnoides, Irpex lacteus, Leucoagaricus cf. cinereus, Marasmius cf. bellus, Marasmius sp., Nothopanus hygrophanus, Oudemansiella canarii, Pycnoporus sanguineus, Phellinus sp., and Tyromyces duracinus presented significant activity against one or more of the target microorganisms. Eight isolates were active only against bacteria while three inhibited exclusively the growth of fungi. Two extracts presented wide antimicrobial spectrum and were active against both fungi and bacteria. Differences in the bioactivity of extracts obtained from isolates from the same species were observed.
Rosa
Luiz Henrique
LH
Departamento de Microbiologia, Instituto de Ci ncias Biol gicas, Universidade Federal de Minas Gerais Rachou-Fiocruz, Belo Horizonte, MG, Brasil.
Machado
Kátia M Gomes
KM
Jacob
Camila Cristina
CC
Capelari
Marina
M
Rosa
Carlos Augusto
CA
Zani
Carlos Leomar
CL
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D002175:Candida / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010936:Plant Extracts