title: Towards conformationally-locked difluorosugar analogues: an unexpected sense of dihydroxylation.
abstract: Difluorinated cyclooctenones, synthesised using RCM, can be used as templates for stereoselective oxidative transformations to products that undergo transannular reactions to afford conformationally-locked analogues of 2-deoxy-2,2-difluorosugars with different stereochemical relationships between the C-2 and C-3 hydroxyl groups.
authors.affiliation: Department of Chemistry, University of Leicester, University Road, Leicester LE1 7RH, UK.
authors.forename: John
authors.initials: J
authors.lastname: Fawcett
authors.forename: Gerry A
authors.initials: GA
authors.lastname: Griffiths
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Percy
authors.forename: Stéphane
authors.initials: S
authors.lastname: Pintat
authors.forename: Clive A
authors.initials: CA
authors.lastname: Smith
authors.forename: Neil S
authors.initials: NS
authors.lastname: Spencer
authors.forename: Emi
authors.initials: E
authors.lastname: Uneyama
mesh_terms: D002236:Carbohydrate Conformation; D003500:Cyclization; D003837:Deoxy Sugars / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D006900:Hydroxylation; D013237:Stereoisomerism
chemical_list: D003837:Deoxy Sugars; D005461:Fluorine