Regulation of glutamate receptor RNA editing and ADAR mRNA expression in developing human normal and Down's syndrome brains.
In human brain, developmental up-regulation in RNA editing at the Q/R site was evident in GluR5 and GluR6, but GluR2 editing in the white matter was down-regulated. Each ADAR mRNA expression was up-regulated in the gray matter, whereas differently regulated in the white matter. ADAR2 mRNA was not overexpressed in the brains of Down's syndrome subjects, nor was there any evidence of changes in the RNA editing efficiency of their GluRs.
Kawahara
Yukio
Y
Department of Neurology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8655, Japan.
Ito
Kyoko
K
Sun
Hui
H
Ito
Masayuki
M
Kanazawa
Ichiro
I
Kwak
Shin
S
D000243:Adenosine Deaminase / Q000096:biosynthesis* / Q000235:genetics; D000328:Adult; D000368:Aged; D001921:Brain / Q000033:anatomy & histology / Q000254:growth & development / Q000378:metabolism*; D004314:Down Syndrome / Q000235:genetics* / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D017393:RNA Editing / Q000502:physiology*; D012333:RNA, Messenger / Q000096:biosynthesis; D016601:RNA-Binding Proteins; D017470:Receptors, Glutamate / Q000235:genetics*
D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D017470:Receptors, Glutamate; C567955:ADARB1 protein, human; D000243:Adenosine Deaminase