title: Adiponectin is independently associated with glycosylated haemoglobin.
abstract: BACKGROUND
  In humans, adiponectin has been demonstrated to circulate in inverse proportion to the degree of insulin resistance.
  
  
  OBJECTIVE
  To investigate the association between adiponectin and glycosylated haemoglobin (HbA1c) in a population-based study.
  
  
  METHODS
  Two hundred and ninety-seven individuals aged 30-75 years were enrolled in a cross-sectional study. They included patients with type 2 (non-insulin-dependent) diabetes mellitus and stable, good metabolic control (n=32) and individuals with glucose intolerance (n=54). Adiponectin was measured using a sandwich enzyme-linked immunosorbent assay (intra-assay and interassay coefficients of variation 3.3 and 7.4% respectively).
  
  
  RESULTS
  Adiponectin correlated with age (r=0.161; P=0.006), body mass index (r=-0.197; P=0.001), diastolic blood pressure (r=-0.181; P=0.005), fasting glucose and HbA1c (r=-0.251 and r=-0.22 respectively; P<0.0001), high-density lipoprotein cholesterol (r=0.442; P<0.001) and serum triglycerides (r=-362; P<0.001). In multiple regression analysis, sex, age, fasting and post-load glucose, and adiponectin independently contributed to 40% of the variance in HbA1c. Among individuals with normal glucose tolerance, fasting glucose (P=0.0033), post-load glucose (P=0.0015), age (P=0.001) and adiponectin (P=0.0083) independently contributed to 21% of the variance in HbA1c.
  
  
  CONCLUSIONS
  Adiponectin is significantly associated with altered glucose metabolism and independently contributes to the variance of HbA1c in a population-based manner.
authors.affiliation: Unit of Diabetes, Endocrinology and Nutrition, University Hospital of Girona Dr Josep Trueta, Girona, Spain. uden.jmfernandezreal@htrueta.scs.es
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Fernández-Real
authors.forename: Patricia
authors.initials: P
authors.lastname: Botas-Cervero
authors.forename: Abel
authors.initials: A
authors.lastname: López-Bermano
authors.forename: Roser
authors.initials: R
authors.lastname: Casamitjana
authors.forename: Tohru
authors.initials: T
authors.lastname: Funahashi
authors.forename: Elías
authors.initials: E
authors.lastname: Delgado
authors.forename: Shinji
authors.initials: S
authors.lastname: Kihara
authors.forename: Wifredo
authors.initials: W
authors.lastname: Ricart
mesh_terms: D052242:Adiponectin; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D006442:Glycated Hemoglobin / Q000031:analogs & derivatives* / Q000032:analysis*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000032:analysis*; D013223:Statistics as Topic
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; C025617:glucosylated hemoglobin A