title: Side-to-side differences in transcranial Doppler parameters in normotensive and preeclamptic pregnant women.
abstract: OBJECTIVE
  This study was undertaken to investigate whether women with preeclampsia demonstrate larger side-to-side velocity differences in the middle cerebral artery (MCA) compared with normotensive pregnant women.
  
  
  METHODS
  Forty-one preeclamptic women and 50 normotensive pregnant women were studied during the third trimester. Transcranial Doppler ultrasound was used to measure peak, end-diastolic, and mean velocities in both MCAs. An asymmetry index was calculated as 100 x Rt-Lt//(Rt+Lt)/2, for each of the following parameters: mean velocity (Vm), pulsatility index (PI), and cerebral perfusion pressure (CPP). Student t test, Pearson correlation, and regression analysis were used. Significance was taken as P<.05.
  
  
  RESULTS
  Both normotensive and preeclamptic pregnant women showed good correlation between Rt and Lt MCA Vm (R>0.8, P<.0001), PI (R>0.6, P.0001), and CPP (R>0.8, P<.0001). There were no differences in the asymmetry index for Vm, PI, or CPP between the two groups.
  
  
  CONCLUSIONS
  Preeclampsia does not appear to induce greater side-to-side velocity differences in the MCA distribution.
authors.affiliation: Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, USA. asriskin@newmail.net
authors.forename: Shlomit
authors.initials: S
authors.lastname: Riskin-Mashiah
authors.forename: Michael A
authors.initials: MA
authors.lastname: Belfort
authors.forename: George R
authors.initials: GR
authors.lastname: Saade
authors.forename: Alan J
authors.initials: AJ
authors.lastname: Herd
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D001794:Blood Pressure; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D020768:Middle Cerebral Artery / Q000000981:diagnostic imaging* / Q000502:physiology; D011225:Pre-Eclampsia / Q000000981:diagnostic imaging*; D011247:Pregnancy; D011674:Pulse; D017585:Ultrasonography, Doppler, Transcranial