title: [Absence seizure--recent physiopathologic data].
abstract: The progresses in clarifying the normal and pathologic cellular and molecular mechanisms are reflected in the elucidation of the way some of the most common forms of generalized seizure--absence seizures--occur and are produced. Intrinsic properties of the thalamic neurons that give them the ability to release or preserve oscillatory, low-frequency neuronal discharges, and the thalamo-cortical feedback mechanism seem to explain the pathogenesis of absence seizures. The involvement of GABA receptors in the regulation of membrane calcium channels, as well as their genetically-induced changes are new pieces in the pathogenic puzzle.
authors.affiliation: Clinica I Neurologie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
authors.forename: D
authors.initials: D
authors.lastname: Cuciureanu
authors.forename: Felicia
authors.initials: F
authors.lastname: Stefanache
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology; D002648:Child; D004832:Epilepsy, Absence / Q000235:genetics / Q000503:physiopathology*; D025461:Feedback, Physiological; D006801:Humans; D051379:Mice; D018079:Receptors, GABA / Q000502:physiology; D013788:Thalamus / Q000502:physiology
chemical_list: D018079:Receptors, GABA