Dendritic cell endothelium interaction in autoimmunity.
Monocyte derived dendritic cells play a central role in controlling immunity by activating naïve T lymphocytes. Monocytes can leave the blood stream by endothelial cell transmigration and differentiation into dendritic cells. A fundamental aspect of dendritic cell biology is their capacity to engulf tissue antigens and revers-migrate into lymph nodes. In lymph nodes dendritic cells can traffic to T-cell areas where they activate naïve T-cells. Throughout this review we are developing a model of in vivo activation of auto-reactive T-cells by activated dendritic cells.
Schlichting
C L
CL
Department of Surgery, Devision of Transplantation Surgery, School of Medicine, University Hospital, University Rostock, Schillingalle 35, 18055 Rostock, Germany. christoph.schlichting@drschlichting.de
Schareck
W D
WD
Weis
M
M
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology*; D002465:Cell Movement / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology*; D004730:Endothelium, Vascular / Q000276:immunology*; D006801:Humans; D008221:Lymphoid Tissue / Q000276:immunology / Q000502:physiology