Quantification of tumor vascularity with contrast-enhanced sonography: correlation with magnetic resonance imaging and fluorodeoxyglucose autoradiography in an implanted tumor.
OBJECTIVE
To correlate the quantitated tumor vascularity of implanted murine tumors as depicted by contrast-enhanced sonography with estimates made with magnetic resonance imaging and with estimates of the percentage of viable (metabolically active) tumor as depicted by fluorodeoxyglucose autoradiography.


METHODS
Implanted tumors in 10 mice were imaged with contrast-enhanced sonography, magnetic resonance imaging, and fluorodeoxyglucose autoradiography. Tumor vascularity was estimated with each modality and compared with the percentage of viable tumor.


RESULTS
Quantitated estimates of tumor vascularity with contrast-enhanced sonography closely correlated (r = 0.95) with estimates made by magnetic resonance imaging and with the percentage of viable tumor (r = 0.93) as depicted by fluorodeoxyglucose autoradiography.


CONCLUSIONS
Contrast-enhanced sonography accurately depicts tumor vascularity in these implanted tumors. Tumor vascularity correlated with the amount of metabolically active tumor.
Fleischer
Arthur C
AC
Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2675, USA. arthur.fleischer@vanderbilt.edu
Donnelly
Edwin F
EF
Grippo
Ryan J
RJ
Black
Amy S
AS
Hallahan
Dennis E
DE
D000818:Animals; D001345:Autoradiography; D003287:Contrast Media; D005466:Fluorocarbons; D019788:Fluorodeoxyglucose F18; D017709:Fractals; D008175:Lung Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging*; D008279:Magnetic Resonance Imaging; D051379:Mice; D008863:Microspheres; D019275:Radiopharmaceuticals; D014463:Ultrasonography
D003287:Contrast Media; D005466:Fluorocarbons; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; C042852:perflutren