title: Pharmacokinetic study and trial for preparation of enteric-coated capsule containing insulinomimetic vanadyl compounds: implications for clinical use.
abstract: To treat patients suffering from diabetes mellitus, we developed several types of orally active vanadyl complexes to replace painful insulin injections, and prepared them in the form of enteric-coated capsules containing vanadium compounds. Pharmacokinetic analysis demonstrated that these capsules enhance the bioavailability of pharmacologically active vanadyl species.
authors.affiliation: Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan. sakurai@mb.kyoto-phu.ac.jp
authors.forename: Hiromu
authors.initials: H
authors.lastname: Sakurai
authors.forename: Jun
authors.initials: J
authors.lastname: Fugono
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yasui
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002214:Capsules; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D005780:Gelatin / Q000737:chemistry; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics; D010848:Picolinic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D014638:Vanadates / Q000008:administration & dosage / Q000493:pharmacokinetics; D017968:Vanadium Compounds / Q000008:administration & dosage* / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D002214:Capsules; D007004:Hypoglycemic Agents; D009942:Organometallic Compounds; D010848:Picolinic Acids; D017968:Vanadium Compounds; C402804:bis(6-methylpicolinato)oxovanadium(IV); C095866:bis(picolinato)oxovanadium(IV); D014638:Vanadates; C034028:vanadyl sulfate; D005780:Gelatin