title: Structure-activity relationships of non-imidazole H(3) receptor ligands. Part 3: 5-Substituted 3-phenyl-1,2,4-oxadiazoles as potent antagonists.
abstract: Further SAR studies on novel histamine H(3) receptor antagonists are presented. Compound 14bb is a potent antagonist of both the rat cortical and human clone receptors, and is demonstrated to act functionally as an antagonist in an in vivo mouse dipsogenia model.
authors.affiliation: Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA. greg.gfesser@abbott.com
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Gfesser
authors.forename: Henry
authors.initials: H
authors.lastname: Zhang
authors.forename: Jurgen
authors.initials: J
authors.lastname: Dinges
authors.forename: Gerard B
authors.initials: GB
authors.lastname: Fox
authors.forename: Jia Bao
authors.initials: JB
authors.lastname: Pan
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Esbenshade
authors.forename: Betty B
authors.initials: BB
authors.lastname: Yao
authors.forename: David
authors.initials: D
authors.lastname: Witte
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Miller
authors.forename: Chae-Hee
authors.initials: CH
authors.lastname: Kang
authors.forename: Kathy M
authors.initials: KM
authors.lastname: Krueger
authors.forename: Youssef L
authors.initials: YL
authors.lastname: Bennani
authors.forename: Arthur A
authors.initials: AA
authors.lastname: Hancock
authors.forename: Ramin
authors.initials: R
authors.lastname: Faghih
mesh_terms: D000818:Animals; D006633:Histamine Antagonists / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008024:Ligands; D051379:Mice; D023421:Models, Animal; D015394:Molecular Structure; D010069:Oxadiazoles / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D018100:Receptors, Histamine H3 / Q000737:chemistry* / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D006633:Histamine Antagonists; D008024:Ligands; D010069:Oxadiazoles; D018100:Receptors, Histamine H3