Spatial patterns of alpha-synuclein positive glial cytoplasmic inclusions in multiple system atrophy.
In cases of multiple system atrophy (MSA), glial cytoplasmic inclusions (GCI) were distributed randomly or present in large diffuse clusters (>1,600 microm in diameter) in most areas studied. These spatial patterns contrast with those reported for filamentous neuronal inclusions in the tauopathies and alpha-synucleinopathies.
Armstrong
Richard A
RA
Vision Sciences, Aston University, Birmingham, United Kingdom. R.A.Armstrong@aston.ac.uk
Lantos
Peter L
PL
Cairns
Nigel J
NJ
D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000473:pathology*; D009415:Nerve Net / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009454:Neurofibrils / Q000473:pathology; D009457:Neuroglia / Q000473:pathology*; D009474:Neurons / Q000473:pathology; D009849:Olivopontocerebellar Atrophies / Q000473:pathology; D012791:Shy-Drager Syndrome / Q000473:pathology; D020955:Striatonigral Degeneration / Q000473:pathology; D051843:Synucleins; D051844:alpha-Synuclein
D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein