title: EVG, the remnants of a primordial bilaterian's synteny of functionally unrelated genes.
abstract: Extant genomes are the result of repeated duplications and subsequent divergence of primordial genes that assembled the genomes of the first living beings. Increased information on genome maps of different species is revealing conserved syntenies among different vertebrate taxa, which allow to trace back the history of current chromosomes. However, inferring neighboring relationships between genes of more primitive genomes has proven to be very difficult. Most often, the ancestral arrangements of genes have been lost by multiple histories of internal duplications, chromosomal breaks, and large-scale genomic rearrangements. Here we describe a gene arrangement of nonrelated genes that seems to have endured evolution, at least from the separation of the two major clades of bilateria: deuterostomia and protostomia, approximately 1 billion years ago. In its simplest conception, this gene cluster, named EVG, groups the genes for a glucose transporter, an enolase, and a vesicle-associated membrane protein (VAMP). EVG might represent the evolutionary remnants of the gene organization of an ancient bilaterian genome.
authors.affiliation: Departamento de Biología Celular y Desarrollo, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Velázquez 144, 28006 Madrid, Spain.
authors.forename: Begoña
authors.initials: B
authors.lastname: Granadino
authors.forename: Javier
authors.initials: J
authors.lastname: Rey-Campos
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics; D019143:Evolution, Molecular; D020440:Gene Duplication; D006801:Humans; D008322:Mammals / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D009004:Monosaccharide Transport Proteins / Q000235:genetics; D005810:Multigene Family; D010751:Phosphopyruvate Hydratase / Q000235:genetics; D050683:R-SNARE Proteins; D026801:Synteny
chemical_list: D008565:Membrane Proteins; D009004:Monosaccharide Transport Proteins; D050683:R-SNARE Proteins; D010751:Phosphopyruvate Hydratase