Comparison of measured and calculated lipophilicity of substituted aurones and related compounds.
A molecule library containing 55 aurone- and thioaurone-type structures has been designed and synthesised. Reversed phase high performance liquid chromatographic (RP-HPLC) method has been developed to separate these compounds and to characterise their lipophilicity by experimental method (k'). The experimental lipophilicity data have been compared with the computer calculated lipophilicity parameters (CLOGPs) of the same molecules. In general, good correlations between the measured and calculated lipophilicities have been found with the exception of structure isomers and compounds capable for hydrogen bonding. The chromatographic method was suitable to separate the structure (ortho and para) isomers of aurone and thioaurones and was sensitive enough to differentiate their lipophilicities. Our findings suggest the usefulness of the chromatographic method in fast characterisation of the lipophilicity of structurally closely related molecules.
Hallgas
B
B
Department of Medical Chemistry, Hungarian Academy of Sciences, Semmelweis University, Puskin u. 9, H-1088 Budapest, Hungary.
Patonay
T
T
Kiss-Szikszai
A
A
Dobos
Zs
Z
Hollósy
F
F
Eros
D
D
Orfi
L
L
Kéri
Gy
G
Idei
M
M
D001572:Benzofurans / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006860:Hydrogen Bonding; D008055:Lipids / Q000737:chemistry*; D015394:Molecular Structure; D012680:Sensitivity and Specificity; D012984:Software; D013329:Structure-Activity Relationship
D001572:Benzofurans; D008055:Lipids; C486837:aurone