title: Successful treatment of acquired haemophilia with prednisolone therapy.
abstract: Acquired hemophilia is a rare, life threatening coagulopathy in adults caused by the development of autoantibodies against to factor VIII. No general consensus exists on the best therapeutic approach. We report here a case that presented with extensive cutaneous and mucosal bleedings due to factor VIII inhibitors and treated successfully with steroid therapy alone but complicated with a life threatening thromboembolic attack during her follow up. In conclusion, corticosteroids are "cost effective therapy" associated with high inhibitor elimination rates and although recurrence of inhibitor in a patient with factor VIII inhibitor is an expected clinical situation thrombosis risk should also be considered.
authors.affiliation: Department of Internal Medicine, Division of Hematology, Uludağ University School of Medicine, Uludağ University Hospital, Bursa, Turkey. ridvanali@uludag.edu.tr
authors.forename: R
authors.initials: R
authors.lastname: Ali
authors.forename: T
authors.initials: T
authors.lastname: Ozçelik
authors.forename: F
authors.initials: F
authors.lastname: Ozkalemkas
authors.forename: V
authors.initials: V
authors.lastname: Ozkocaman
authors.forename: U
authors.initials: U
authors.lastname: Ozan
authors.forename: M
authors.initials: M
authors.lastname: Yalçin
authors.forename: H
authors.initials: H
authors.lastname: Saricaoğlu
authors.forename: A
authors.initials: A
authors.lastname: Tunali
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000368:Aged; D005260:Female; D006467:Hemophilia A / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D011239:Prednisolone / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D011239:Prednisolone