Studies on some glitazones having pyridine as the linker unit.
Molecular modeling on various well-known glitazones carrying a pyridine ring instead of benzene ring as the middle linker unit showed conformational rigidity as compared to their parent molecules. Blocking the lone pair of electrons on the pyridine N, made them flexible once again. A few representatives of these analogues were synthesized and their efficacy as PPARgamma agonists evaluated.
Ramachandran
Uma
U
Department of Pharmaceutical Technology, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S. Nagar-160 062, India. umaram54@yahoo.com
Mital
Alka
A
Bharatam
Prasad V
PV
Khanna
Smriti
S
Rao
Poduri Rama
PR
Srinivasan
Krishnamoorthy
K
Kumar
Rakesh
R
Chawla
Harmander Pal Singh
HP
Kaul
Chaman Lal
CL
Raichur
Suryaprakash
S
Chakrabarti
Ranjan
R
D002460:Cell Line; D006358:Hot Temperature; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists; D045162:Thiazolidinediones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014157:Transcription Factors / Q000819:agonists
D011725:Pyridines; D018160:Receptors, Cytoplasmic and Nuclear; D045162:Thiazolidinediones; D014157:Transcription Factors; C023666:pyridine