Ectopic uterine stem cell tumors in the hamster kidney. A unique model for estrogen-induced oncogenesis.
Estrogens are intimately involved in the causation of some of the most prevalent cancers afflicting women, particularly, breast, endometrial, cervico-vaginal, and possibly ovarian. Therefore, it has become particularly pertinent to elucidate the molecular mechanisms whereby estrogens elicit their oncogenic actions so that better prevention strategies can be developed. The estrogen-induced Syrian hamster tumors of the kidney have emerged as one of the most intensively studied in vivo models in solely estrogen oncogenesis. An advantage of this model is that the tumors occur in the absence of any intervening morphologic changes, but rather they are the result of the continuous progression of some interstitial stem cells in the kidney leading to tumor formation. Evidence is presented that the origin of these tumors is derived from ectopic "uterine" stem cells, which are responsive to estrogenic hormones. Their steroid receptor and many other gene alterations have been delineated. Importantly, a crucial early event in this solely estrogen-induced oncogenic process is the overexpression and amplification of c-myc and its protein product. Chromosomal instability, in both early and large frank tumors, is another important characteristic of this process. This later feature has commonly been shown in solely estrogen-induced murine mammary tumors, and in ductal carcinomas in situ and in primary invasive ductal breast carcinomas. These changes are considered crucial in eliciting estrogen-induced tumorigenesis.
Li
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JJ
Hormonal Carcinogenesis Laboratory, Department of Pharmacology, Toxicology and Therapeutics, and the Kansas Cancer Institute University of Kansas Medical Center, Kansas City, Kansas 66160-7312, USA.
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D000782:Aneuploidy; D000818:Animals; D043171:Chromosomal Instability; D006224:Cricetinae; D004195:Disease Models, Animal; D004967:Estrogens / Q000502:physiology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D007680:Kidney Neoplasms / Q000209:etiology* / Q000235:genetics; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000235:genetics; D014411:Neoplastic Stem Cells; D014176:Protein Biosynthesis; D011960:Receptors, Estrogen / Q000502:physiology; D014594:Uterine Neoplasms / Q000473:pathology*
D004967:Estrogens; D011960:Receptors, Estrogen