Synthesis and biological evaluation of (-)-laulimalide analogues.
Analogues of the marine natural product (-)-laulimalide were prepared by total synthesis and evaluated in vitro for anticancer activity.
Gallagher
Brian M
BM
Eisai Research Institute, 100 Research Drive, Wilmington, MA 01887, USA. brian_gallagher@eri.eisai.com
Fang
Francis G
FG
Johannes
Charles W
CW
Pesant
Marc
M
Tremblay
Martin R
MR
Zhao
Hongjuan
H
Akasaka
Kozo
K
Li
Xiang-yi
XY
Liu
Junke
J
Littlefield
Bruce A
BA
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D018942:Macrolides; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D043823:Taxoids / Q000138:chemical synthesis* / Q000737:chemistry; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D018942:Macrolides; D043823:Taxoids; C117305:laulimalide