title: Development of new reconstructive techniques: use of Integra in combination with fibrin glue and negative-pressure therapy for reconstruction of acute and chronic wounds.
abstract: Large wounds resulting from severe injuries are generally treated with extended reconstructive operations (e.g., free flaps), which are accompanied by long hospitalizations and risks of infection, thrombosis, and flap loss. Integra is a collagen template that can be used for reconstruction of defects. The take rate and the rate of infection are essential for the successful use of Integra (Johnson and Johnson, Hamburg, Germany). Whether the take rate and integration of Integra could be improved with the use of fibrin glue and negative-pressure therapy was assessed. Between January of 2002 and December of 2002, patients with large defects who underwent Integra grafting for reconstruction were randomly divided into groups receiving either a new treatment with fibrin glue-anchored Integra and postoperative negative-pressure therapy or conventional treatment. Demographic features, cause of the wound, location of the wound, take rate, complications of Integra coverage, time from Integra coverage to skin transplantation, and functional and aesthetic results were assessed. Twelve patients (with similar group distributions with respect to sex, age, and location and cause of the injury) were included in the study. The take rate was 78 +/- 8 percent in the conventional treatment group and 98 +/- 2 percent in the fibrin/negative-pressure therapy group (p < 0.003). The mean period from Integra coverage to skin transplantation was 24 +/- 3 days in the conventional treatment group but only 10 +/- 1 days in the fibrin/negative-pressure therapy group (p < 0.002). The decrease in the interval between coverage with Integra and skin transplantation resulted in shorter hospital stays. The use of fibrin glue and negative-pressure therapy in combination with Integra could shorten the period from coverage to integration, which would be beneficial in terms of decreased risks of infection, thrombosis, and catabolism. Therefore, it is suggested that Integra be used in combination with fibrin glue and negative-pressure therapy to improve clinical outcomes and shorten hospital stays, with decreased risks of accompanying complications.
authors.affiliation: Department of General Surgery, University of Regensburg, Germany. mcjeschke@hotmail.com
authors.forename: Marc G
authors.initials: MG
authors.lastname: Jeschke
authors.forename: Christoph
authors.initials: C
authors.lastname: Rose
authors.forename: Peter
authors.initials: P
authors.lastname: Angele
authors.forename: Bernd
authors.initials: B
authors.lastname: Füchtmeier
authors.forename: Michael N
authors.initials: MN
authors.lastname: Nerlich
authors.forename: Ulrich
authors.initials: U
authors.lastname: Bolder
mesh_terms: D000328:Adult; D000368:Aged; D001672:Biocompatible Materials; D002648:Child; D002809:Chondroitin Sulfates; D003094:Collagen; D005121:Extremities / Q000293:injuries; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019651:Plastic Surgery Procedures / Q000379:methods; D016038:Skin Transplantation; D017768:Skin, Artificial; D017695:Soft Tissue Injuries / Q000601:surgery / Q000628:therapy*; D014618:Vacuum; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D015718:Fibrin Tissue Adhesive; C114835:integra artificial skin; D002809:Chondroitin Sulfates; D003094:Collagen