title: [A study on biomarkers of styrene].
abstract: OBJECTIVE
  To study the biomarkers of styrene and to provide theoretical basis for bio-monitoring of styrene.
  
  
  METHODS
  Urinary mandalic acid (MA), phenylglyoxalic acid (PGA) and mercapturic acid (MUA) of styrene were examined by high performance liquid chromatography (HPLC).
  
  
  RESULTS
  The correlation regression equations between exposure dose and MA, PGA and MUA level in morning urinary samples were: ŷ = 2.58x + 70.82; ŷ = 1.66x + 37.42; ŷ = 0.05x + 0.55 respectively. The correlation regression equations between exposure dose and MA, PGA and MUA level in post-shift urinary samples were: ŷ = 1.85x + 89.02; ŷ = 1.33x + 4.32; ŷ = 0.04x + 0.68 respectively. All showed close dose-response relationship.
  
  
  CONCLUSIONS
  The level of MA, PGA and MUA in morning or post-shift urinary samples may be used as bio-monitoring indexes of styrene.
authors.affiliation: Shandong Institute of Labor Health and Occupational Disease, Jinan, Shandon 250062, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Shao
authors.forename: Xiao-yun
authors.initials: XY
authors.lastname: Wang
authors.forename: Hu
authors.initials: H
authors.lastname: Cheng
authors.forename: Yi-kang
authors.initials: YK
authors.lastname: Shi
authors.forename: Meng-ping
authors.initials: MP
authors.lastname: Zhang
mesh_terms: D000111:Acetylcysteine / Q000652:urine*; D000328:Adult; D015415:Biomarkers; D002851:Chromatography, High Pressure Liquid; D004784:Environmental Monitoring; D006038:Glyoxylates / Q000652:urine*; D006801:Humans; D008297:Male; D008333:Mandelic Acids / Q000652:urine*; D012044:Regression Analysis; D020058:Styrene / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D006038:Glyoxylates; D008333:Mandelic Acids; C012482:phenylglyoxylic acid; D020058:Styrene; D000111:Acetylcysteine