Chemistry of renieramycins. Part 4.synthesis of a simple natural marine product, 6-hydroxy-7-methoxyisoquinolinemethanol.
6-Hydroxy-7-methoxyisoquinolinemethanol (15) and mimosamycin (1) were recently isolated from a marine sponge, Haliclona sp. The former was prepared in ten steps from vanillin (22) in 26% overall yield using an isopropyl for phenol protection.
Saito
Naoki
N
Meiji Pharmaceutical University, Tokyo, Japan. naoki@my-pharm.ac.jp
Tanaka
Chieko
C
Satomi
Tomoo
T
Oyama
Chigusa
C
Kubo
Akinori
A
D000818:Animals; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D044005:Tetrahydroisoquinolines / Q000737:chemistry*
C489868:6-hydroxy-7-methylisoquinolinemethanol; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C018106:mimosamycin