title: [Effect of electromagnetic pulse irradiation on mice reproduction].
abstract: OBJECTIVE
  To evaluate the effect of electromagnetic pulse (EMP) irradiation on mice reproduction.
  
  
  METHODS
  Female/male Kunming mice, 6 - 8 weeks old, prior to mating, or female after pregnancy were treated with whole body irradiation by 6 x 10(4) V/m electromagnetic pulse (EMP) for five times. The pregnant mice were killed on the 18th days, and teratological markers were analysed.
  
  
  RESULTS
  EMP irradiation caused no significant changes in most of female organ weight and organ/body weight ratio. But it caused significant shortening in tail length of live foetus in the female mice before conception (prior to mating) or after pregnancy (P < 0.05), and obvious decrease in male offspring ratio (0.85 +/- 0.09 vs 1.09 +/- 0.17, P < 0.05). The male offspring ratio also significantly decreased (0.76 +/- 0.18 vs 1.09 +/- 0.17, P < 0.01) after male mice irradiated by EMP. The tail length of live foetus was shortened and male offspring sex ratio was increased after both male and female mice were irradiated by EMP. EMP irradiation also caused a significantly higher fetal death rate than normal control (P < 0.05). The embryo absorption rate was increased after irradiation except that was decreased in male mice.
  
  
  CONCLUSIONS
  EMP irradiation has effect on pregnancy and offspring development in both male and female mice before mating and in female mice after pregnancy.
authors.affiliation: Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China.
authors.forename: Shui-ming
authors.initials: SM
authors.lastname: Wang
authors.forename: De-wen
authors.initials: DW
authors.lastname: Wang
authors.forename: Rui-yun
authors.initials: RY
authors.lastname: Peng
authors.forename: Hao-yu
authors.initials: HY
authors.lastname: Chen
authors.forename: Ya-bing
authors.initials: YB
authors.lastname: Gao
authors.forename: Xiao-zhe
authors.initials: XZ
authors.lastname: Cao
authors.forename: Xue-mei
authors.initials: XM
authors.lastname: Cui
authors.forename: Mei-lan
authors.initials: ML
authors.lastname: Zhao
mesh_terms: D000818:Animals; D005260:Female; D005333:Fetus / Q000528:radiation effects*; D008297:Male; D051379:Mice; D011247:Pregnancy; D011827:Radiation; D012098:Reproduction / Q000528:radiation effects*