Human papillomavirus type 16 and TP53 mutation in oral cancer: matched analysis of the IARC multicenter study.
TP53 mutations were analyzed in 35 human papillomavirus (HPV) type 16 DNA-positive cancers of the oral cavity and oropharynx and in 35 HPV DNA-negative cancers matched by subsite, country, sex, age, and tobacco and alcohol consumption. Wild-type TP53 was found more frequently in cancer specimens that contained HPV16 DNA than in those that did not. All 14 HPV16 DNA-positive cancers in HPV16 E6 antibody-positive patients contained wild-type TP53, compared with 50% of corresponding HPV DNA-negative cancers (matched odds ratio, infinity; 95% confidence interval, 1.4- infinity ). In contrast, for HPV16 DNA-positive cancers in E6-negative patients, wild-type TP53 frequency was similar to that in corresponding HPV DNA-negative cancers (matched odds ratio, 1.0; 95% confidence interval, 0.2-5.4). TP53 inactivation is a major mechanism of HPV-related carcinogenesis in the oral cavity and oropharynx. The role of HPV in cancers also containing TP53 mutations remains to be clarified.
Dai
Min
M
IARC, Lyon, France.
Clifford
Gary M
GM
le Calvez
Florence
F
Castellsagué
Xavier
X
Snijders
Peter J F
PJ
Pawlita
Michael
M
Herrero
Rolando
R
Hainaut
Pierre
P
Franceschi
Silvia
S
D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers; D004279:DNA, Viral / Q000235:genetics / Q000302:isolation & purification; D005260:Female; D005843:Geography; D006801:Humans; D008297:Male; D009062:Mouth Neoplasms / Q000235:genetics* / Q000821:virology*; D009959:Oropharyngeal Neoplasms / Q000235:genetics; D027383:Papillomaviridae / Q000235:genetics*; D012907:Smoking / Q000453:epidemiology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D017931:DNA Primers; D004279:DNA, Viral; D016159:Tumor Suppressor Protein p53