Mechanisms of pulmonary fibrosis.
Tissue injury evokes highly conserved, tightly regulated inflammatory responses and less well-understood host repair responses. Both inflammation and repair involve the recruitment, activation, apoptosis, and eventual clearance of key effector cells. In this review, we propose the concept of pulmonary fibrosis as a dysregulated repair process that is perpetually "turned on" even though classical inflammatory pathways may be dampened or "switched off." Significant regional heterogeneity, with varied histopathological patterns of inflammation and fibrosis, has been observed in individual patients with idiopathic pulmonary fibrosis. We discuss environmental factors and host response factors, such as genetic susceptibility and age, that may influence these varied manifestations. Better understanding of the mechanisms of lung repair, which include alveolar reepithelialization, myofibroblast differentiation/activation, and apoptosis, should offer more effective therapeutic options for progressive pulmonary fibrosis.
Thannickal
Victor J
VJ
Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA. vjt@umich.edu
Toews
Galen B
GB
White
Eric S
ES
Lynch
Joseph P
JP
Martinez
Fernando J
FJ
D006801:Humans; D008168:Lung / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D011658:Pulmonary Fibrosis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology*