title: [Leukotrienes as inflammation mediators].
abstract: Leukotrienes are biologically active metabolites derived from arachidonic acid playing an important role in inflammatory responses. There are two main groups of leukotrienes: dihydroxyleukotrienes (LTB4) and cysteinyl-leukotrienes (LTC4, LTD4, LTE4). By activating specific G-protein coupled receptors, leukotrienes take part in immune responses, like activation and chemotaxis of leukocytes. Several studies have shown that leukotrienes may play a significant role in pathomechanisms of inflammatory diseases of human airways, skin, digestive tract and heart.
authors.affiliation: Katedra i Zakład Immunologii Klinicznej Uniwersytetu Medycznego w Łodzi.
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Woszczek
authors.forename: Rafał
authors.initials: R
authors.lastname: Pawliczak
authors.forename: Marek L
authors.initials: ML
authors.lastname: Kowalski
mesh_terms: D002633:Chemotaxis / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology* / Q000378:metabolism; D007975:Leukotriene B4 / Q000276:immunology; D017997:Leukotriene C4 / Q000276:immunology; D017998:Leukotriene D4 / Q000276:immunology; D017999:Leukotriene E4 / Q000276:immunology; D015289:Leukotrienes / Q000276:immunology* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology
chemical_list: D018836:Inflammation Mediators; D015289:Leukotrienes; D007975:Leukotriene B4; D017997:Leukotriene C4; D017998:Leukotriene D4; D017999:Leukotriene E4