Coagulation inhibitors in preeclamptic pregnant women.
OBJECTIVE
Our objective was to detect clinical evaluation of coagulation inhibitors in preeclamptic and normotensive pregnant women and to determine their important role in pathogenesis of preeclampsia.


METHODS
A total of 20 mild, 20 severe preeclamptic and 45 normotensive pregnant women were included in this study. The plasma value of antithrombin III (AT-III) activity, proteins C and S activity, PT, PTT, fibrinogen and platelet counts were determined.


RESULTS
The values AT-III were lower in women with severe preeclampsia than in controls (p<0.05). In all groups, there was no significantly difference in the concentration of protein C activity, protein S and fibrinogen (p>0.05). The plasma thrombocyte counts were significantly lower in severe preeclamptic women than in normotensive women (p<0.05). There was no significant difference in the prothrombin time value in all groups, but a significantly difference with regard to partial thromboplastin time between severe preeclamptic and the control group (p<0.0001). It was longer than the control.


CONCLUSIONS
The markers of hemostasis activation such as protein S, protein C activity together with fibrinogen levels are not useful tools but the reduction of AT-III and platelet counts would seem useful in different pathological situations in pregnancy to predict and monitor the severity of the condition.
Osmanağaoğlu
Mehmet A
MA
Department of Obstetrics and Gynecology, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey. osmanaga@meds.ktu.edu.tr
Topçuoğlu
Kenan
K
Ozeren
Mehmet
M
Bozkaya
Hasan
H
D000328:Adult; D000990:Antithrombin III / Q000032:analysis; D001777:Blood Coagulation; D016022:Case-Control Studies; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D006973:Hypertension; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D011225:Pre-Eclampsia / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D011247:Pregnancy; D011256:Pregnancy Outcome; D011486:Protein C / Q000032:analysis; D017293:Protein S / Q000032:analysis; D011517:Prothrombin Time
D011486:Protein C; D017293:Protein S; D000990:Antithrombin III; D005340:Fibrinogen