Proteoglycans and brain repair.
Proteoglycans are complex molecules composed of long, unbranched sugar chains attached to a protein core. In the mammalian central nervous system, they are a major component of the extracellular matrix and of the cellular surface. After a central nervous system injury, their expression in the lesion area changes strongly and contributes to the inhibition of axon regrowth and brain repair.
Properzi
Francesca
F
Brain Repair Centre, Cambridge University, Cambridge CB2 2PY, United Kingdom.
Fawcett
James W
JW
D000818:Animals; D001927:Brain Diseases / Q000503:physiopathology*; D001930:Brain Injuries / Q000503:physiopathology*; D006801:Humans; D009416:Nerve Regeneration / Q000502:physiology*; D011509:Proteoglycans / Q000502:physiology*
D011509:Proteoglycans