title: Tumor markers. An update approach for their prognostic significance. Part I.
abstract: Identification of prognostic tumor markers is a main strategy for planning treatment and predicting outcome of patients with various malignancies. This article reviews a panel of proliferation markers, hormone receptors, oncogene products and apoptosis regulators that have shown potential as prognostic indicators in common human cancers. At present, steroid receptors and the c-erbB-2 gene are the only tissue-based markers accepted in clinical practice, having an established role in breast cancer prognosis. Other markers e.g., the p53 gene, look promising as prognostic factors in different kinds of cancer.
authors.affiliation: Department of Pathology, Medical School, University of Ioannina, University Campus, 45110 Ioannina, Greece. nagnanti@cc.uoi.gr
authors.forename: N J
authors.initials: NJ
authors.lastname: Agnantis
authors.forename: A C
authors.initials: AC
authors.lastname: Goussia
authors.forename: D
authors.initials: D
authors.lastname: Stefanou
mesh_terms: D014408:Biomarkers, Tumor; D006801:Humans; D009369:Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor