title: Primary malignant mixed mullerian tumor of the vagina immunohistochemically confirmed.
abstract: METHODS
  We report the case of a 74-year old woman who presented with an ulcerated mass of the vagina. Histology of the tumor showed malignant mixed mullerian tumor (MMMT) with squamous and spindle cell stromal components, associated with high-grade vaginal intraepithelial neoplasia (VaIN 3). Immunohistochemical study of the neoplasm revealed that the malignant stromal tumor was a high-grade leiomyosarcoma. Despite the multimodal therapeutic approach, the patient died within 11 months.
  
  
  CONCLUSIONS
  The vagina is a rare site of presentation of primary MMMTs and the present case is the second one immunohistochemically confirmed.
authors.affiliation: Department of Pathology, Alexandra Hospital, Vassilissis Sophies 80, 115 28 Athens, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Sotiropoulou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Haidopoulos
authors.forename: George
authors.initials: G
authors.lastname: Vlachos
authors.forename: Athanasios
authors.initials: A
authors.lastname: Pilalis
authors.forename: Alexandros
authors.initials: A
authors.lastname: Rodolakis
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Diakomanolis
mesh_terms: D000368:Aged; D000855:Anorexia; D001706:Biopsy; D002584:Cervix Uteri / Q000601:surgery; D003475:Curettage; D017809:Fatal Outcome; D005221:Fatigue; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods*; D008279:Magnetic Resonance Imaging; D018200:Mixed Tumor, Mullerian / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014625:Vaginal Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy