title: Hazard identification and predictability of children's health risk from animal data.
abstract: Children differ from adults both physiologically and behaviorally. These differences can affect how and when exposures to xenobiotics occur and the resulting responses. Testing using animal models may be used to predict whether children display novel toxicities not observed in adults or whether children are more or less sensitive to known toxicities. Historically, evaluation of developmental toxicity has focused on gestational exposures and morphological changes resulting from this exposure. Functional consequences of gestational exposure and postnatal exposure have not been as well studied. Difficulties with postnatal toxicity evaluations include divergent differentiation of structure, function and physiology across species, lack of understanding of species differences in functional ontogeny, and lack of common end points and milestones across species.
authors.affiliation: Eli Lilly and Company, Greenfield, Indiana 46140, USA. lmorford@lilly.com
authors.forename: LaRonda L
authors.initials: LL
authors.lastname: Morford
authors.forename: Judith W
authors.initials: JW
authors.lastname: Henck
authors.forename: William J
authors.initials: WJ
authors.lastname: Breslin
authors.forename: John M
authors.initials: JM
authors.lastname: DeSesso
mesh_terms: D000818:Animals; D002648:Child; D002657:Child Development; D002669:Child Welfare; D002675:Child, Preschool; D004785:Environmental Pollutants / Q000506:poisoning*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D023421:Models, Animal; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D018570:Risk Assessment
chemical_list: D004785:Environmental Pollutants