Integration of metabolic and mitogenic signal transduction in skeletal muscle.
Exercise has diverse effects on metabolic and mitogenic signaling pathways in human skeletal muscle, implying specificity of intracellular signaling cascades. The role of several parallel signaling cascades are discussed in an effort to assign a physiological role for these targets in the regulation of exercise-mediated responses on metabolism and gene expression.
Hawley
John A
JA
Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, Victoria, Australia. john.hawley@rmit.edu.au
Zierath
Juleen R
JR
D015444:Exercise / Q000502:physiology; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000032:analysis / Q000378:metabolism*; D009119:Muscle Contraction / Q000502:physiology; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000502:physiology; D010807:Physical Endurance; D012680:Sensitivity and Specificity; D015398:Signal Transduction / Q000502:physiology*
D020928:Mitogen-Activated Protein Kinases