Tenascin C and cathepsin d expression in adipocytic tumors: an immunohistochemical investigation of 43 cases.
Cathepsin D (CatD) and tenascin C (Tn-C) have been implicated in invasion and metastasis of carcinomas. However, little is known about CatD and Tn-C distribution in mesenchymal tumors. Therefore, we aimed to investigate the expression of Tn-C and CatD in adipocytic tumors. Tn-C and CatD expressions in 27 lipomas, 5 atypical lipomatous tumor/well-differentiated liposarcomas (ALT/WDLS) and 11 liposarcomas (LS) were evaluated by immunohistochemistry and scored semiquantitatively. CatD expression was higher in ALT/WDLS than in lipomas (p<0.001), and higher in LS than in ALT/WDLS (p=0.009). Stromal Tn-C expression was higher in ALT/WDLS than in lipomas (p=0.02), but no difference was observed between ALT/WDLS and LS (p>0.05). These results indicate that Tn-C and CatD may be markers of locally aggressive or malignant behavior in adipocytic tumors.
Sis
Banu
B
Dokuz Eylül University School of Medicine, Department of Pathology, Izmir, Turkey.
Tuna
Burcin
B
Yorukoglu
Kutsal
K
Kargi
Aydanur
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002402:Cathepsin D / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008067:Lipoma / Q000378:metabolism / Q000473:pathology; D008080:Liposarcoma / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018205:Neoplasms, Adipose Tissue / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D019063:Tenascin / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; D019063:Tenascin; D002402:Cathepsin D