[Role of homocysteine in the acute phase of stroke].
BACKGROUND
Hyperhomocysteinemia is a well known vascular risk factor. However its action mechanism and its role in the acute phase of stroke have not been determined.


OBJECTIVE
To study plasmatic homocysteine levels in the acute stroke of different etiologies and evaluate its role as a prognostic factor.


METHODS
We determined plasmatic homocysteine in 136 consecutive patients with stroke. Mean time from symptoms onset was 4.6 hours.


RESULTS
Higher than normal homocysteine levels were found in ischemic stroke (n= 119 13.1 micromol/l; 43 % of patients > normality rank) and intracranial hemorrhage (n= 17 micromol/l; 24 % of patients > normality rank). The etiological distribution of ischemic stroke was the following: 42 cardioembolic (29.4%; median Hcy: 13.1 micromol/l), 20 atherothrombotic (14 %; Hcy: 12.7 micromol/l), 33 lacunar (23.1 %; Hcy: 11.8 micromol/l) and 24 undetermined (16.8%; Hcy:15.2 micromol/l). No significant differences were found between these groups (p=0.19). Those patients who presented early neurological deterioration presented higher homocysteine levels than those who remained stable or improved (median 13.3 n=16 v 11.3 n=113; p=0.061).


CONCLUSIONS
High homocysteine levels are associated to all etiologic stroke subtypes and intracranial hemorrhage. Patients who experienced early neurological worsening tend to have higher homocysteine levels.
Ribo
M
M
Unidad Neurovascular, Hospital Vall d'Hebron, Barcelona, Spain. marcriboj@hotmail.com
Montaner
J
J
Monasterio
J
J
Molina
C
C
Arenillas
J
J
Chacon
P
P
Alvarez-Sabin
J
J
D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000097:blood / Q000209:etiology; D002543:Cerebral Hemorrhage / Q000097:blood / Q000209:etiology; D005260:Female; D006710:Homocysteine / Q000097:blood / Q000502:physiology*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000453:epidemiology / Q000209:etiology
D006710:Homocysteine