title: Octodon degus: a diurnal, social, and long-lived rodent.
abstract: Octodon degus is a moderate-sized, precocious, but slowly maturing, hystricomorph rodent from central Chile. We have used this species to study a variety of questions about circadian rhythms in a diurnal mammal that readily adapts to most laboratory settings. In collaboration with others, we have found that a number of fundamental features of circadian function differ in this diurnal rodent compared with nocturnal rodents, specifically rats or hamsters. We have also discovered that many aspects of the circadian system are sexually dimorphic in this species. However, the sexual dimorphisms develop in the presence of pubertal hormones, and the sex differences do not appear until after gonadal puberty is complete. The developmental timing of the sex differences is much later than in the previously studied altricial, rapidly developing rat, mouse, or hamster. This developmental timing of circadian function is reminiscent of that reported for adolescent humans. In addition, we have developed a model that demonstrates how nonphotic stimuli, specifically conspecific odors, can interact with the circadian system to hasten recovery from a phase-shift of the light:dark cycle (jet lag). Interestingly, the production of the odor-based social signal and sensitivity to it are modulated by adult gonadal hormones. Data from degu circadian studies have led us to conclude that treatment of some circadian disorders in humans will likely need to be both age and gender specific. Degus will continue to be valuable research animals for resolving other questions regarding reproduction, diabetes, and cataract development.
authors.affiliation: Reproductive Science Program, Department of Psychology and Neuroscience Program, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Theresa M
authors.initials: TM
authors.lastname: Lee
mesh_terms: D000367:Age Factors; D000822:Animal Husbandry / Q000379:methods*; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D023421:Models, Animal; D008954:Models, Biological; D009812:Odorants; D005082:Physical Exertion / Q000502:physiology; D012377:Rodentia; D012727:Sex Characteristics