title: Meningococcal disease in catalonia 1 year after mass vaccination campaign with meningococcal group C polysaccharide vaccine.
abstract: BACKGROUND
  The aim of this study was to investigate the clinical and epidemiological characteristics of meningococcal disease in Catalonia (Spain) after vaccination with the polysaccharide vaccine.
  
  
  METHODS
  Cases were collected by the Statutory Diseases Reporting System.
  
  
  RESULTS
  176 cases were reported, an overall incidence of 2.9/100,000 persons/year. 60% of cases occurred during winter and spring. The case fatality rate was 6.3%. The highest age incidence was in children under 2 years of age (48/100,000 persons/year). Comparison of the cases detected by the Statutory Diseases Reporting System with those obtained by the Microbiological Reporting System shows that meningococcal disease surveillance in Catalonia was relatively complete (95.7%), with a positive predictive value of 66.3%. 115 cases (65%) were culture-confirmed with a rate of 1.9/100,000 persons/year. 86 (75%) cases were due to Neisseria meningitidis serogroup B and 21 to serogroup C (18%).
  
  
  CONCLUSIONS
  Although infections due to serogroup C have decreased after mass vaccination with the polysaccharide vaccine, it is likely that the number of infections will decrease further with the conjugate meningococcal group C vaccine.
authors.affiliation: General Directorate of Public Health, Generalitat de Catalunya, Pavello Ave Maria, Trav. De les Corts, 131-159, E-08028 Barcelona, Spain.
authors.forename: N
authors.initials: N
authors.lastname: Cardeñosa
authors.forename: A
authors.initials: A
authors.lastname: Domínguez
authors.forename: A
authors.initials: A
authors.lastname: Martínez
authors.forename: J
authors.initials: J
authors.lastname: Alvarez
authors.forename: H
authors.initials: H
authors.lastname: Pañella
authors.forename: P
authors.initials: P
authors.lastname: Godoy
authors.forename: S
authors.initials: S
authors.lastname: Minguell
authors.forename: N
authors.initials: N
authors.lastname: Camps
authors.forename: J A
authors.initials: JA
authors.lastname: Vázquez
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017589:Immunization Programs; D007223:Infant; D008297:Male; D032541:Mass Vaccination; D008585:Meningitis, Meningococcal / Q000175:diagnosis / Q000453:epidemiology / Q000517:prevention & control; D008589:Meningococcal Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000008:administration & dosage; D008875:Middle Aged; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage*; D015995:Prevalence; D012042:Registries; D018570:Risk Assessment; D012698:Serologic Tests; D017678:Sex Distribution; D013030:Spain / Q000453:epidemiology; D015996:Survival Rate; D013997:Time Factors
chemical_list: D022401:Meningococcal Vaccines; D011135:Polysaccharides, Bacterial; C037676:meningococcal group C polysaccharide