On the origins of triterpenoid skeletal diversity.
The triterpenoids are a large group of natural products derived from C(30) precursors. Nearly 200 different triterpene skeletons are known from natural sources or enzymatic reactions that are structurally consistent with being cyclization products of squalene, oxidosqualene, or bis-oxidosqualene. This review categorizes each of these structures and provides mechanisms for their formation.
Xu
Ran
R
Department of Chemistry, Rice University, 6100 S Main Street, Houston, TX 77005, USA.
Fazio
Gia C
GC
Matsuda
Seiichi P T
SP
D000438:Alcohols / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D003500:Cyclization; D013185:Squalene / Q000031:analogs & derivatives / Q000378:metabolism; D014315:Triterpenes / Q000737:chemistry* / Q000378:metabolism*
D000438:Alcohols; D014315:Triterpenes; D013185:Squalene