99mTc labelled model drug carriers - labeling, stability and organ distribution in rats.
The surface characteristics of intravenously administered particulate drug carriers decisively influence the protein adsorption that is regarded as a key factor for the in vivo fate of the carriers. We labeled surface-modified polymer particles with the gamma-emitting radioisotope 99mTc in order to test their properties in blood and follow their in vivo fate. The biodistribution was different in various types of polymer particles. As expected, labeled particles were found in the mononuclear phagocyte system in a large scale but markedly different biodistribution for some particles were also shown.
Wunderlich
Gerd
G
Department of Nuclear Medicine, Carl Gustav Carus Medical School, University of Technology, Dresden, Germany. gerd.wunderlich@mailbox.tu-dresden.de
Grüning
Thomas
T
Paulke
Bernd R
BR
Lieske
Antje
A
Kotzerke
Jörg
J
D000818:Animals; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D004355:Drug Stability; D005260:Female; D007275:Injections, Intravenous; D007553:Isotope Labeling / Q000379:methods; D008657:Metabolic Clearance Rate; D008863:Microspheres; D009928:Organ Specificity; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D013499:Surface Properties; D013667:Technetium / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D004337:Drug Carriers; D019275:Radiopharmaceuticals; D013667:Technetium