title: Association of the calpain-10 gene with type 2 diabetes mellitus in a Mexican population.
abstract: Variation in the calpain-10 gene (CAPN10) has been associated with risk of type 2 diabetes in the Mexican American population of Starr County, Texas. We typed five polymorphisms in the calpain-10 gene (SNP-43, -43, -63, and -110 and Indel-19) to test for association with type 2 diabetes in 248 individuals representative of the mestizo population of Mexico City and Orizaba, Mexico including 134 patients with type 2 diabetes and 114 subjects with normal fasting blood glucose levels. We found a significant difference in SNP-44 allele and genotype frequencies between type 2 diabetic and non-diabetic subjects. The rare allele at SNP-44 was associated with increased risk of type 2 diabetes (odds ratio (OR)=2.72, 95% confidence interval (CI)=1.16-6.35, P=0.017). SNP-110, which is in perfect linkage disequilibrium with SNP-44, was also associated with type 2 diabetes. The SNP-43, Indel-19, and SNP-63 haplogenotype 112/121 associated with significantly increased risk (OR=2.16, 95% CI=1.31-3.57) of type 2 diabetes in Mexican Americans was not associated with significantly increased in risk in Mexicans (OR=1.15, 95% CI=0.57-2.34). The results suggest that variation in CAPN10 affects risk of type 2 diabetes in the mestizo population of central Mexico (Mexico City and Orizaba) and in Mexican Americans (Starr County, Texas).
authors.affiliation: Department of Biochemistry, Medicine and Human Genetics, The University of Chicago, 5841 S. Maryland Ave., MC1028, Chicago, IL 60637, USA. ldelbosq@uchicago.edu
authors.forename: Laura
authors.initials: L
authors.lastname: del Bosque-Plata
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Aguilar-Salinas
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Tusié-Luna
authors.forename: Salvador
authors.initials: S
authors.lastname: Ramírez-Jiménez
authors.forename: Maribel
authors.initials: M
authors.lastname: Rodríguez-Torres
authors.forename: Moisés
authors.initials: M
authors.lastname: Aurón-Gómez
authors.forename: Erika
authors.initials: E
authors.lastname: Ramírez
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Velasco-Pérez
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ramírez-Silva
authors.forename: Francisco
authors.initials: F
authors.lastname: Gómez-Pérez
authors.forename: Craig L
authors.initials: CL
authors.lastname: Hanis
authors.forename: Takafumi
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: Issei
authors.initials: I
authors.lastname: Yoshiuchi
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Cox
authors.forename: Graeme I
authors.initials: GI
authors.lastname: Bell
mesh_terms: D000368:Aged; D002154:Calpain / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008800:Mexico / Q000208:ethnology; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D013781:Texas
chemical_list: D002154:Calpain; C415197:calpain 10