title: First total synthesis of murisolin.
abstract: The first and concise total synthesis of murisolin (1) was accomplished using asymmetric alkynylation and Sonogashira coupling as the key steps. The threo/trans/threo-type THF ring moiety was constructed with excellent stereoselectivity by asymmetric alkynylation of 1,6-heptadiyne to alpha-tetrahydrofuranic aldehyde, which was also prepared via the asymmetric alkynylation.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
authors.forename: Naoyoshi
authors.initials: N
authors.lastname: Maezaki
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Tominaga
authors.forename: Naoto
authors.initials: N
authors.lastname: Kojima
authors.forename: Minori
authors.initials: M
authors.lastname: Yanai
authors.forename: Daisuke
authors.initials: D
authors.lastname: Urabe
authors.forename: Tetsuaki
authors.initials: T
authors.lastname: Tanaka