Cervical carcinogenesis: the role of co-factors and generation of reactive oxygen species.
Several HPV co-factors have been proposed, some more or less consistently associated with cervical dysplasia and cancer risk. More research, using prospective cohort designs, is needed to further describe where in carcinogenesis these factors are working and to assess the biological mechanism of these factors. In addition, further research is needed to define the role of various hormonal contraceptive formulations in promoting cervical carcinogenesis. While many interesting scientific questions remain to be answered, results from the numerous epidemiological studies conducted to date indicate that cervical dysplasia and cancer may be reduced if the oxidant antioxidant ratio is shifted to more of and antioxidant profile. In addition to cervical cancer screening, a reduction in cervical cancer incidence may be accomplished by reducing tobacco use, increasing nutritional status, and utilizing barrier contraception to prevent infection with other sexually acquired infections. This paper is available too at: http://www.insp.mx/salud/index.html.
Giuliano
Anna
A
Cancer Prevention and Control Program, Arizona Cancer Center, University of Arizona, Tucson, AZ, USA. agiuliano@azcc.arizona.edu
D014408:Biomarkers, Tumor / Q000097:blood; D005260:Female; D006801:Humans; D030361:Papillomavirus Infections / Q000150:complications; D017382:Reactive Oxygen Species; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000209:etiology* / Q000378:metabolism
D014408:Biomarkers, Tumor; D017382:Reactive Oxygen Species