title: Vibsane diterpenoids from the leaves and flowers of Viburnum odoratissimum.
abstract: In addition to the five known compounds 5-epi-vibsanin H, vibsanins C, H, and G, and aldovibsanin B, four new diterpenes, 5-epi-vibsanin G (1), 18-O-methylvibsanin G (2), vibsanin M (3), and aldovibsanin C (4), were isolated from an acetone extract of the leaves and flowers of Viburnum odoratissimum by bioassay-directed fractionation. In addition, two acetyl derivatives 5 and 6 were obtained from the naturally occurring diterpenes. The structures of the new compounds were established on the basis of NMR spectral analysis, including COSY, HMQC, HMBC, and NOESY correlations. The compounds were evaluated for cytotoxicity against human nasopharyngeal carcinoma (HONE-1) tumor cells and human gastric cancer (NUGC-3) cells.
authors.affiliation: Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, 80424 Taiwan, Republic of China. ycshen@mail.nsysu.edu.tw
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
authors.forename: Chung-Ling
authors.initials: CL
authors.lastname: Lin
authors.forename: Shih-Chao
authors.initials: SC
authors.lastname: Chien
authors.forename: Ashraf Taha
authors.initials: AT
authors.lastname: Khalil
authors.forename: Chin-Lien
authors.initials: CL
authors.lastname: Ko
authors.forename: Chih-Hsin
authors.initials: CH
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D035264:Flowers / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013624:Taiwan; D014407:Tumor Cells, Cultured; D027925:Viburnum / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes