title: Variables explaining the duration of hospitalization in children under two years of age admitted with acute airway infections: does respiratory syncytial virus have a direct impact?
abstract: BACKGROUND
  Duration of hospitalization is influenced by many factors. It is an important parameter for quality of care. So far it is unknown, whether respiratory syncytial virus (RSV) etiology itself contributes to the time in hospital.
  
  
  METHODS
  Children under 2 years of age admitted with a lower respiratory tract infection in 3 hospitals (1 tertiary and 2 secondary centers) in northern Germany were included in an unmatched, hospital-based case-control study. Cases were children tested positive for RSV by multiplex RT-PCR. One control group consisted of children tested negative for RSV in the multiplex-RT-PCR and a second control group consisted of patients in whom no PCR was done. Since only 4 to 5% in the latter group and thus 2% of the study population were misclassified, this group could be involved in the analysis.
  
  
  RESULTS
  The median days of hospitalization was 7 days; 9 days in the RSV-positive group, 8 and 6 days in the RSV-negative and non-PCR group, respectively. The time in hospital was diminishing over the 4 year observation period. Duration of hospitalization was best predicted by--young age, presence of an underlying condition, disease entity--being pneumonia or bronchiolitis, prematurity, earlier epidemiologic year and intercostal retractions. Not predictive were: RSV-etiology, center, duration of illness, wheezing, C-reactive protein level and consolidation on the chest x-ray (all on admission).
  
  
  CONCLUSIONS
  RSV-etiology is influencing the duration of hospitalization only indirectly via its predilection for the very young age and certain underlying conditions--not by RSV itself. In spite of considerable variation of patient populations between secondary and tertiary care facilities and locally different care practices, the treatment center pre se did not influence the duration of hospitalization significantly. Further rationalization of treatment is, however, possible.
authors.affiliation: University Children's Hospital, Pediatric Infectious Diseases, Kiel, Germany. wiegl@pediatrics.uni-kiel.de
authors.forename: J A I
authors.initials: JA
authors.lastname: Weigl
authors.forename: W
authors.initials: W
authors.lastname: Puppe
authors.forename: H-J
authors.initials: HJ
authors.lastname: Schmitt
mesh_terms: D000208:Acute Disease; D001988:Bronchiolitis / Q000175:diagnosis / Q000453:epidemiology; D001991:Bronchitis / Q000175:diagnosis / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007902:Length of Stay / Q000706:statistics & numerical data*; D008297:Male; D015999:Multivariate Analysis; D011024:Pneumonia, Viral / Q000175:diagnosis / Q000453:epidemiology; D011785:Quality Assurance, Health Care / Q000706:statistics & numerical data; D018357:Respiratory Syncytial Virus Infections / Q000175:diagnosis / Q000453:epidemiology*; D012136:Respiratory Syncytial Viruses / Q000235:genetics; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000453:epidemiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors