title: Photoaging and oxidative stress.
abstract: Photoaging is significantly different from chronological aging in both clinical and histological appearance. It has been suggested that oxidative stress, generated by ultraviolet radiation (UVR), leads to photoaging over a long period. The presence of 8-OHdG, and oxidatively modified proteins such as 4-hydroxy-2-nonenal-modified protein, 3-L-nitro-tyrosine and N(-epsilon) (carboxymethyl)lysine in UV-exposed skin specimens, supports this theory. The pathophysiology of photoaging of the skin caused by chronic inflammation after UVR is reviewed and discussed, with a focus on oxidative stress.
authors.affiliation: Department of Dermatology, Graduate School of Medicine, Kobe University, Kobe, Japan. chikako@med.kobe-u.ac.jp
authors.forename: Chikako
authors.initials: C
authors.lastname: Nishigori
authors.forename: Yukari
authors.initials: Y
authors.lastname: Hattori
authors.forename: Yaeno
authors.initials: Y
authors.lastname: Arima
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Miyachi
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000032:analysis; D002478:Cells, Cultured; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000032:analysis; D005347:Fibroblasts / Q000737:chemistry; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000032:analysis; D051379:Mice; D008812:Mice, Hairless; D018384:Oxidative Stress; D012867:Skin / Q000737:chemistry / Q000528:radiation effects*; D015595:Skin Aging / Q000502:physiology*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000032:analysis; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: C002744:3-nitrotyrosine; D014443:Tyrosine; C048496:N(6)-carboxymethyllysine; D000080242:8-Hydroxy-2'-Deoxyguanosine; D001120:Arginine; C062187:pentosidine; D003849:Deoxyguanosine; D008239:Lysine