Treatment duration of reversal reaction: a reappraisal. Back to the past.
In this paper, earlier data on the length of prednisolone treatment are re-examined. Based on those data and supported by the literature and the author's own observations, it can be concluded that type I leprosy reaction should be treated with prednisolone for a longer period than the 12 weeks, advised by the WHO. The paper also warns against silent nerve damage that may occur when prednisolone is discontinued early.
Naafs
Ben
B
IJsselmeerziekenhuizen Emmeloord/Lelystad and Leiden University Medical Centre, The Netherlands. benaafs@dds.nl
D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007918:Leprosy / Q000150:complications* / Q000188:drug therapy*; D008134:Long-Term Care; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000209:etiology / Q000517:prevention & control*; D011239:Prednisolone / Q000008:administration & dosage*; D016032:Randomized Controlled Trials as Topic; D020127:Recovery of Function; D018570:Risk Assessment; D012678:Sensation Disorders / Q000209:etiology / Q000517:prevention & control; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
D011239:Prednisolone