[Experimental study on composite transplantation of acellular porcine dermal matrix and micro-autograft to repair deep burn wound].
OBJECTIVE
To observe the effect of composite skin graft consisting of heterogeneous (swine) acellular dermal matrix and combined micro-autograft and allograft with the aim at overcoming shortcomings of repairing materials for burn wound.


METHODS
Forty-eight Sprague-Dawley rats with full-thickness skin defect on the back were grafted with the composite skin (compound skin grafting group, G) and autologous particulate skin (control group, C), respectively. The area of wound healing and the rates of wound contraction were measured. Tissue specimens were harvested for histological examination.


RESULTS
The composite skin graft resulted in less contracture and better elasticity. Compared with group C, the wound contraction rate was lower significantly. Histological examination revealed that there was full differentiation of epithelium, orderly collagen arrangement and intact basement membrane.


CONCLUSIONS
Coverage of wound with composite skin composing heterogeneous (swine) acellular dermal matrix and autologous particulate skin could promote wound healing and improve wound healing quality.
Liu
Qiang
Q
Institute of Burns, 304 th Hospital of PLA, Beijing 100037, China.
Chai
Jia-Ke
JK
Yang
Hong-Ming
HM
Yin
Hui-Nan
HN
D000818:Animals; D002056:Burns / Q000628:therapy*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D016038:Skin Transplantation / Q000379:methods*; D013552:Swine; D014182:Transplantation, Autologous / Q000379:methods; D014184:Transplantation, Homologous / Q000379:methods