8-year follow-up in a randomized trial of one vs two transcervical insertions of quinacrine pellets for sterilization in Indonesia.
OBJECTIVE
To evaluate the efficacy of one vs two insertions of quinacrine and the long-term safety of quinacrine sterilization (QS) 8 years after the procedure in Indonesia.


METHODS
Between March 1993 and September 1995, a randomized trial was conducted in 6 academic centers in Indonesia. In February 2003, a follow-up study was undertaken in Bandung, one of those centers. This survey required a home visit of each woman. A questionnaire was designed to elicit information regarding current general health status, method failure, pregnancy outcomes and other contraceptive methods now used by women who experienced failures. Among the 70 patients receiving a single insertion of quinacrine pellets, 14.3% had become pregnant. There were no pregnancies among the 30 who received 2 insertions. All the women were found to be in good health. No long-term side effects or complications were identified.


CONCLUSIONS
The two-insertion protocol is unmistakably superior to the single insertion. This study provides further evidence that QS is a safe contraceptive method.
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Department of Obstetrics and Gynecology, Dr. Hasan Sadikin Hospital/Medical School, Padjadaran University, Bandung, Indonesia. dragias@bdg.centrin.net.id
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004343:Drug Implants; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007214:Indonesia; D008875:Middle Aged; D011247:Pregnancy; D011796:Quinacrine / Q000008:administration & dosage* / Q000009:adverse effects; D012102:Reproductive Control Agents / Q000008:administration & dosage* / Q000009:adverse effects; D013246:Sterilization, Tubal / Q000379:methods*; D013997:Time Factors
D004343:Drug Implants; D012102:Reproductive Control Agents; D011796:Quinacrine