Mouse models of pancreatic cancer: the fur is finally flying!
Pancreatic cancer remains one of the most lethal of all human malignancies. Until recently, preclinical studies have been hampered by the absence of mouse models faithfully recapitulating critical elements of the human disease. However, recent months have witnessed a flurry of activity with respect to prospective mouse models. This progress now allows the evaluation of novel strategies for early detection, chemoprevention, and therapy and also provides new insights regarding the potential for differentiated and undifferentiated cell types to act as cells of origin for pancreatic ductal adenocarcinoma.
Leach
Steven D
SD
The Sidney Kimmel Cancer Center at Johns Hopkins, 600 North Wolfe Street/Osler 603, Baltimore, MD 21287, USA. stleach@jhmi.edu
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D002273:Carcinogens / Q000378:metabolism; D021441:Carcinoma, Pancreatic Ductal / Q000188:drug therapy / Q000473:pathology*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism; D004195:Disease Models, Animal; D016147:Genes, Tumor Suppressor / Q000502:physiology; D011905:Genes, ras / Q000502:physiology; D006801:Humans; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology*; D010183:Pancreatic Ducts / Q000473:pathology; D010190:Pancreatic Neoplasms
D016588:Anticarcinogenic Agents; D002273:Carcinogens; D019941:Cyclin-Dependent Kinase Inhibitor p16