title: Muscle glycogen depletion and increased oxidative phosphorylation following status epilepticus.
abstract: We describe complete glycogen depletion and increased respiratory chain enzyme activity in a muscle biopsy obtained prior to the demise of a patient in multiorgan failure following status epilepticus. These findings validate the theoretical basis of muscle energy turnover during status epilepticus: the increased demand for energy leads to complete depletion of glycogen reserves. The attempt to preserve adenosine triphosphate requirements results in increased activity of respiratory chain enzymes.
authors.affiliation: Mitochondrial Disease Clinic, Wolfson Medical Center, Holon, Sackler School of Medicine, Tel-Aviv University, Israel.
authors.forename: Marina
authors.initials: M
authors.lastname: Michelson-Kerman
authors.forename: Nathan
authors.initials: N
authors.lastname: Watemberg
authors.forename: Andreea
authors.initials: A
authors.lastname: Nissenkorn
authors.forename: Eli
authors.initials: E
authors.lastname: Gilad
authors.forename: Menachem
authors.initials: M
authors.lastname: Sadeh
authors.forename: Tally
authors.initials: T
authors.lastname: Lerman-Sagie
mesh_terms: D001706:Biopsy; D002648:Child; D004579:Electron Transport / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D004831:Epilepsies, Myoclonic / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006003:Glycogen / Q000378:metabolism*; D006801:Humans; D009102:Multiple Organ Failure / Q000473:pathology; D018482:Muscle, Skeletal / Q000473:pathology*; D013226:Status Epilepticus / Q000473:pathology*
chemical_list: D006003:Glycogen