Association of the calpain-10 gene with type 2 diabetes mellitus in a Mexican population.
Variation in the calpain-10 gene (CAPN10) has been associated with risk of type 2 diabetes in the Mexican American population of Starr County, Texas. We typed five polymorphisms in the calpain-10 gene (SNP-43, -43, -63, and -110 and Indel-19) to test for association with type 2 diabetes in 248 individuals representative of the mestizo population of Mexico City and Orizaba, Mexico including 134 patients with type 2 diabetes and 114 subjects with normal fasting blood glucose levels. We found a significant difference in SNP-44 allele and genotype frequencies between type 2 diabetic and non-diabetic subjects. The rare allele at SNP-44 was associated with increased risk of type 2 diabetes (odds ratio (OR)=2.72, 95% confidence interval (CI)=1.16-6.35, P=0.017). SNP-110, which is in perfect linkage disequilibrium with SNP-44, was also associated with type 2 diabetes. The SNP-43, Indel-19, and SNP-63 haplogenotype 112/121 associated with significantly increased risk (OR=2.16, 95% CI=1.31-3.57) of type 2 diabetes in Mexican Americans was not associated with significantly increased in risk in Mexicans (OR=1.15, 95% CI=0.57-2.34). The results suggest that variation in CAPN10 affects risk of type 2 diabetes in the mestizo population of central Mexico (Mexico City and Orizaba) and in Mexican Americans (Starr County, Texas).
del Bosque-Plata
Laura
L
Department of Biochemistry, Medicine and Human Genetics, The University of Chicago, 5841 S. Maryland Ave., MC1028, Chicago, IL 60637, USA. ldelbosq@uchicago.edu
Aguilar-Salinas
Carlos A
CA
Tusié-Luna
María Teresa
MT
Ramírez-Jiménez
Salvador
S
Rodríguez-Torres
Maribel
M
Aurón-Gómez
Moisés
M
Ramírez
Erika
E
Velasco-Pérez
María Luisa
ML
Ramírez-Silva
Alfredo
A
Gómez-Pérez
Francisco
F
Hanis
Craig L
CL
Tsuchiya
Takafumi
T
Yoshiuchi
Issei
I
Cox
Nancy J
NJ
Bell
Graeme I
GI
D000368:Aged; D002154:Calpain / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008800:Mexico / Q000208:ethnology; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D013781:Texas
D002154:Calpain; C415197:calpain 10