Prospective, randomized trial of diclofenac and ketorolac after refractive surgery.
OBJECTIVE
To compare the effectiveness of diclofenac and ketorolac in relieving corneal pain after refractive surgery, and determine if there is a difference in stinging on instillation.


METHODS
Thirty patients were randomized prospectively to postoperative diclofenac in one eye and ketorolac in the other. Patients and surgeon did not know which medications were used. Ocular postoperative pain and discomfort on instillation of medication were measured after radial keratotomy with a visual analog scale and a questionnaire.


RESULTS
Both medications were highly effective in relieving pain. There was no significant difference in pain relief, or stinging on instillation (P = .29).


CONCLUSIONS
There was no statistical difference in the effectiveness of the medications on pain relief, or in stinging on instillation.
Narváez
Julio
J
Loma Linda University, Department of Ophthalmology, Loma Linda, CA 92354, USA.
Krall
Peter
P
Tooma
Tom S
TS
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D003315:Cornea / Q000187:drug effects / Q000601:surgery; D004008:Diclofenac / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007646:Keratotomy, Radial; D020910:Ketorolac / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009883:Ophthalmic Solutions; D004008:Diclofenac; D020910:Ketorolac