Severe acute respiratory syndrome: public health response and clinical practice update for an emerging disease.
OBJECTIVE
Severe acute respiratory syndrome is an emerging infectious disease with high morbidity and mortality and potential for global spread. This review highlights the salient points of the 2002-2003 outbreak to help clinicians with early recognition, treatment, disease control, and prevention.


RESULTS
Severe acute respiratory syndrome is a respiratory illness caused by a novel coronavirus, severe acute respiratory syndrome-coronavirus. The disease was first recognized in Asia in February 2003 and, over the next several months, spread to more than two dozen countries in North and South America, Europe, and Asia. The disease is characterized by fever with symptomatic and radiographic evidence of pneumonia.


CONCLUSIONS
Because diagnosis cannot be established by clinical findings alone, epidemiologic findings (including history of travel to affected areas, close contact with other case patients, or linkage to clusters of unexplained pneumonia) play a critical role in the diagnostic evaluation. Infection control procedures (including droplet and airborne precautions) are critical for preventing transmission.
Keeler
Natalie
N
Respiratory and Enteric Virus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, and Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. nbk4@cdc.gov
Lingappa
Jairam
J
D002681:China / Q000453:epidemiology; D019411:Clinical Laboratory Techniques; D003140:Communicable Disease Control / Q000379:methods / Q000458:organization & administration / Q000639:trends; D005544:Forecasting; D006801:Humans; D015980:Public Health Practice / Q000331:legislation & jurisprudence / Q000592:standards; D045473:Severe acute respiratory syndrome-related coronavirus / Q000302:isolation & purification; D045169:Severe Acute Respiratory Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000517:prevention & control*