Use of beta-blockers in patients with COPD.
OBJECTIVE
To evaluate the safety and cardiovascular benefits of beta-blocker therapy in patients with chronic obstructive pulmonary disease (COPD).


METHODS
Clinical literature was accessed through MEDLINE (1966-February 2003). Key search terms included chronic obstructive pulmonary disease and adrenergic beta-antagonists.


RESULTS
beta-Blockers are often avoided in patients with COPD because of fear of bronchoconstriction, despite the known cardiovascular mortality benefits. A review of studies evaluating the use of beta-blockers in COPD was undertaken.


CONCLUSIONS
The literature supports the safety and mortality benefits of using beta-blockers in COPD. Patients with mild to moderate COPD should receive cardioselective beta-blocker therapy when a strong indication exists.
Andrus
Miranda R
MR
Harrison School of Pharmacy, Auburn University, Tuscaloosa, AL, USA. mandrus@cchs.ua.edu
Holloway
Katherine P
KP
Clark
Deidre B
DB
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D017723:Drug Utilization Review; D006801:Humans; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D018570:Risk Assessment
D000319:Adrenergic beta-Antagonists