History, challenges and perspectives of cell microencapsulation.
Cell microencapsulation continues to hold significant promise for biotechnology and medicine. The controlled, and continuous, delivery of therapeutic products to the host by immunoisolated cells is a potentially cost-effective method to treat a wide range of diseases. Although there are several issues that need to be addressed, including capsule manufacture, properties and performance, in the past few years, a stepwise analysis on the essential obstacles and limitations has brought the whole technology closer to a realistic proposal for clinical application. This paper summarizes the current situation in the cell encapsulation field and discusses the main events that have occurred along the way.
Orive
Gorka
G
Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, 01006, Vitoria-Gasteiz, Spain
Hernández
Rose Maria
RM
Rodríguez Gascón
Alicia
A
Calafiore
Riccardo
R
Chang
Thomas Ming Swi
TM
de Vos
Paul
P
Hortelano
Gonzalo
G
Hunkeler
David
D
Lacík
Igor
I
Pedraz
José Luis
JL
D017690:Cell Transplantation / Q000379:methods* / Q000639:trends; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems / Q000379:methods* / Q000639:trends; D013678:Technology, Pharmaceutical / Q000379:methods* / Q000639:trends
D020099:Coated Materials, Biocompatible; D004337:Drug Carriers