A role for exocytosis in the spatial regulation of actin organization.
The efficient organization of the actin cytoskeleton is important for many cellular functions. However, how the local actin organization is regulated in a cell is not well understood. By using yeast mutants defective in actin organization and secretion, we demonstrated that exocytosis plays a role in the spatial regulation of actin organization. Our findings suggest that the actin cytoskeleton, exocytosis, and perhaps endocytosis, may depend on each other for efficiency and reinforce each other.
Gao
Xiang-Dong
XD
Department of Cell and Developmental Biology, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104-6058, USA. xdgao@yahoo.com
Albert
Stefan
S
D000199:Actins / Q000502:physiology*; D005089:Exocytosis / Q000502:physiology*
D000199:Actins