[Molecular mechanisms of excitatory synaptic transmission: dynamic regulation of AMPA receptors].
AMPA receptors play central roles for synaptic transmission in the central nervous system in mammals. Here we review the molecular mechanisms for how AMPA receptor subunits are correctly assembled, how AMPA receptors are conveyed to dendrites, and how AMPA receptors are exposed in postsynaptic sites. We also discuss the molecular mechanisms of synaptic plasticity that is the cellular basis of learning and memory.
Kato
Akihiko
A
Department of Physiology, University of California, San Francisco 94107, USA. akato@phy.ucsf.edu
Sugiyama
Hiroyuki
H
D000818:Animals; D017774:Long-Term Potentiation; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology; D021122:Protein Subunits / Q000378:metabolism; D018091:Receptors, AMPA / Q000502:physiology*; D017981:Receptors, Neurotransmitter / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
D021122:Protein Subunits; D018091:Receptors, AMPA; D017981:Receptors, Neurotransmitter; C069474:glutamine receptor