title: Septohippocampal acetylcholine: involved in but not necessary for learning and memory?
abstract: The neurotransmitter acetylcholine (ACh) has been accorded an important role in supporting learning and memory processes in the hippocampus. Cholinergic activity in the hippocampus is correlated with memory, and restoration of ACh in the hippocampus after disruption of the septohippocampal pathway is sufficient to rescue memory. However, selective ablation of cholinergic septohippocampal projections is largely without effect on hippocampal-dependent learning and memory processes. We consider the evidence underlying each of these statements, and the contradictions they pose for understanding the functional role of hippocampal ACh in memory. We suggest that although hippocampal ACh is involved in memory in the intact brain, it is not necessary for many aspects of hippocampal memory function.
authors.affiliation: Department of Psychology and Center for Behavioral Neuroscience, Georgia State University, Atlanta, Georgia 30303, USA. mbparent@gsu.edu
authors.forename: Marise B
authors.initials: MB
authors.lastname: Parent
authors.forename: Mark G
authors.initials: MG
authors.lastname: Baxter
mesh_terms: D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D012686:Septal Nuclei / Q000502:physiology*
chemical_list: D000109:Acetylcholine