title: Recent progress in enzymatic resolution and desymmetrization of pharmaceuticals and their intermediates.
abstract: The literature since August 2000 is surveyed for interesting and useful examples of the resolution or desymmetrization of pharmaceutical entities, their intermediates and potential drug precursors. Existing, putative and developmental drugs used in various therapeutic areas are discussed.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543-4000, USA. jaan.pesti@bms.com
authors.forename: Jaan A
authors.initials: JA
authors.lastname: Pesti
authors.forename: Robert
authors.initials: R
authors.lastname: DiCosimo
mesh_terms: D004789:Enzyme Activation; D006571:Heterocyclic Compounds / Q000138:chemical synthesis; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*; D011355:Prodrugs / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013678:Technology, Pharmaceutical / Q000639:trends*
chemical_list: D006571:Heterocyclic Compounds; D004364:Pharmaceutical Preparations; D011355:Prodrugs