title: Agreement between preoperative core needle biopsy and postoperative invasive breast cancer histopathology is not dependent on the amount of clinical material obtained.
abstract: OBJECTIVE
  To establish the relation between the amount of breast core needle biopsy (CNB) material examined and agreement between preoperative and postoperative histopathology parameters in invasive breast cancer.
  
  
  METHODS
  The CNB and surgical specimen histopathology reports of 113 patients with invasive breast carcinoma were reviewed and the total amount of CNB material examined for each case was determined. Agreement was calculated for tumour type, grade, mitoses, nuclear pleomorphism, and tubule formation. Associations between the amount of CNB material and histopathology agreement before and after surgery were explored using binary logistic regression.
  
  
  RESULTS
  Tumour type and grade agreed in 65.4% and 61.6% of cases, respectively. The components used to calculate grade--nuclear pleomorphism (57.4%), mitoses (59.4%), and tubule formation (55.6%)--agreed slightly less frequently. The proportion of cases with preoperative and postoperative assessments that agreed did not depend on the number of cores collected or the total amount of material examined.
  
  
  CONCLUSIONS
  Neither tumour type and grade, nor the individual components used to calculate grade agreed consistently between the CNB and surgical specimen. The number of cores collected and the total amount of material reviewed by the pathologist does not influence the likelihood of agreement between preoperative and postoperative histopathology reports.
authors.affiliation: School of Medicine, University of Leeds, Leeds, LS2 9NL, UK.
authors.forename: R
authors.initials: R
authors.lastname: O'Leary
authors.forename: K
authors.initials: K
authors.lastname: Hawkins
authors.forename: J C S
authors.initials: JC
authors.lastname: Beazley
authors.forename: M R J
authors.initials: MR
authors.lastname: Lansdown
authors.forename: A M
authors.initials: AM
authors.lastname: Hanby
mesh_terms: D001707:Biopsy, Needle / Q000379:methods; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008938:Mitosis; D009361:Neoplasm Invasiveness; D011182:Postoperative Care; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D015203:Reproducibility of Results