title: Synthesis and biological results of the technetium-99m-labeled 4-nitroimidazole for imaging tumor hypoxia.
abstract: 1-(4-Nitroimidazole-1-yl)-propanhydroxyiminoamide (N4IPA) was synthesized. The biodistribution of 99mTc-N4IPA in mice bearing S180 tumor demonstrated that the complex showed accumulation in tumor and slow clearance from it. The tumor-to-tissue uptake ratios increase with time. These results suggest that 99mTc-N4IPA would be a marker for imaging tumor hypoxia.
authors.affiliation: Department of Applied Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
authors.forename: Taiwei
authors.initials: T
authors.lastname: Chu
authors.forename: Shaowen
authors.initials: S
authors.lastname: Hu
authors.forename: Bing
authors.initials: B
authors.lastname: Wei
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Xinqi
authors.initials: X
authors.lastname: Liu
authors.forename: Xiangyun
authors.initials: X
authors.lastname: Wang
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D008297:Male; D051379:Mice; D009593:Nitroimidazoles / Q000138:chemical synthesis; D015609:Organotechnetium Compounds / Q000138:chemical synthesis; D011877:Radionuclide Imaging; D012510:Sarcoma 180 / Q000000981:diagnostic imaging*; D014018:Tissue Distribution
chemical_list: D009593:Nitroimidazoles; D015609:Organotechnetium Compounds; C052587:4-nitroimidazole