Analysis of the products of genes encompassed by the theoretically predicted pathogenicity islands of Mycobacterium tuberculosis and Mycobacterium bovis.
Sequencing of the genomes of Mycobacterium tuberculosis and Mycobacterium bovis provides a unique opportunity to study the biology of these pathogens on the genomic level. The computational detection of anomalous gene clusters such as those encompassed by pathogenicity islands allows for a narrowing of the study into well-defined groups of genes. Pathogenicity islands of M. tuberculosis (strains H37Rv and CDC1551) as well as M. bovis genomes comprise a group of genes encoding proteins that have been shown to be of immunological importance. The cross-genomic comparison (M. tuberculosis vs M. bovis) resulted in the elucidation of unique proteins in M. tuberculosis. These proteins may play a significant role in the host recognition process.
Zubrzycki
Igor Z
IZ
Institute for Bioinformatics, GSF- National Research Center for Environment and Health, Neueherberg, Germany. igor.zubrzycki@med.uni-rostock.de
D019295:Computational Biology; D005798:Genes, Bacterial / Q000235:genetics*; D016680:Genome, Bacterial; D044404:Genomic Islands / Q000235:genetics*; D023281:Genomics; D008969:Molecular Sequence Data; D005810:Multigene Family; D009163:Mycobacterium bovis / Q000235:genetics*; D009169:Mycobacterium tuberculosis / Q000235:genetics*