title: Oxyphytosterols are present in plasma of healthy human subjects.
abstract: The oxidised derivatives of phytosterols (oxyphytosterols) were identified in plasma samples from thirteen healthy human volunteers, using MS. All the samples contained noticeable quantities of (24R)-5beta,6beta-epoxy-24-ethylcholestan-3beta-ol (beta-epoxysitostanol) and (24R)-ethylcholestan-3beta,5alpha,6beta-triol (sitostanetriol) and also trace levels of (24R)-5alpha,6alpha-epoxy-24-ethylcholestan-3beta-ol (alpha-epoxysitostanol), (24R)-methylcholestan-3beta,5alpha,6beta-triol (campestanetriol) and (24R)-ethylch olest-5-en-3beta-ol-7-one(7-ketositosterol). The amounts of these oxyphytosterols in plasma varied from 4.8 to 57.2 ng/ml. There are two possibilities concerning the origin of these compounds. First, they could come from the small amounts of oxyphytosterols in food. Second, they could originate from the in vivo oxidation of phytosterols in plasma. Very few data actually exist concerning these compounds. Their identification in human samples suggests that further research is necessary in this field.
authors.affiliation: Unité de Nutrition Lipidique, INRA, 17 rue Sully, BP 86510, 21065 DIJON cedex, France. grandgi@dijon.inra.fr
authors.forename: André
authors.initials: A
authors.lastname: Grandgirard
authors.forename: Lucy
authors.initials: L
authors.lastname: Martine
authors.forename: Luc
authors.initials: L
authors.lastname: Demaison
authors.forename: Catherine
authors.initials: C
authors.lastname: Cordelet
authors.forename: Corinne
authors.initials: C
authors.lastname: Joffre
authors.forename: Olivier
authors.initials: O
authors.lastname: Berdeaux
authors.forename: Etienne
authors.initials: E
authors.lastname: Semon
mesh_terms: D000328:Adult; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D010840:Phytosterols / Q000097:blood*; D012855:Sitosterols / Q000097:blood
chemical_list: C116880:7-ketositosterol; D010840:Phytosterols; D012855:Sitosterols