Reversible language regression as an adverse effect of topiramate treatment in children.
Profound language regression developed in three children with epilepsy 4 to 28 weeks after beginning topiramate (TPM). TPM was administered as an adjunctive antiepileptic drug at doses of 2.5 to 6.0 mg/kg/day. Language functions recovered while TPM was being reduced in dose or stopped.
Gross-Tsur
Varda
V
Neuropediatric Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
Shalev
Ruth S
RS
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D017029:Epilepsy, Complex Partial / Q000150:complications / Q000188:drug therapy; D004829:Epilepsy, Generalized / Q000150:complications / Q000188:drug therapy; D004830:Epilepsy, Tonic-Clonic / Q000150:complications / Q000188:drug therapy; D005260:Female; D005632:Fructose / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007806:Language Disorders / Q000139:chemically induced*; D013064:Speech Disorders / Q000139:chemically induced*; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose