title: Cord blood cardiac troponin T and troponin I levels in multiple-gestation neonates.
abstract: The increased mortality and morbidity rates in multiple-gestation neonates are not completely understood. Troponin measurements have a role in situations where the evaluation of the cardiac damage is difficult, such as in cases of unexplained intrauterine fetal growth restriction or death. These conditions, along with perinatal hypoxic risk and in utero ischemic damage, are frequently found in multiple gestations. In this context, a myocardial damage could be expected more frequently in multiple than in singleton births. We hypothesized that cord blood cardiac troponin T and troponin I, markers of myocardial damage, could be different between singleton and multiple pregnancies and, among twins, between the first- and the second-born twin. Troponins T and I and creatine kinase MB concentrations were not increased in twins at birth and were not different between the first- and the second-born twin. These data suggest that myocardial damage, evaluated by cardiac troponin T, troponin I, and creatine kinase MB measurements, does not seem to be a relevant problem in multiple-gestation neonates.
authors.affiliation: Pediatric Department, University of Padova Medical School, Padova, Italy. trevo@pediatria.unipd.it
authors.forename: Daniele
authors.initials: D
authors.lastname: Trevisanuto
authors.forename: Mariangela
authors.initials: M
authors.lastname: Pitton
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Doglioni
authors.forename: Sara
authors.initials: S
authors.lastname: Altinier
authors.forename: Martina
authors.initials: M
authors.lastname: Zaninotto
authors.forename: Mario
authors.initials: M
authors.lastname: Plebani
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Zanardo
mesh_terms: D001722:Birth Order; D003402:Creatine Kinase / Q000097:blood; D052279:Creatine Kinase, MB Form; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D011247:Pregnancy; D011272:Pregnancy, Multiple; D019210:Troponin I / Q000097:blood*; D020107:Troponin T / Q000097:blood*; D014427:Twins
chemical_list: D007527:Isoenzymes; D019210:Troponin I; D020107:Troponin T; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form