title: Fibre intake and prostate cancer risk.
abstract: Dietary fibre has been reported to protect from several neoplasms, but the issue remains controversial. No previous study considered in depth the topic of fibres and prostate cancer. A multicentre case-control study was conducted in Italy from 1991 to 2002, including 1,294 men with incident, histologically confirmed prostate cancer and 1,451 controls admitted to the same network of hospitals as cases with acute nonmalignant conditions. Multivariate odds ratios (OR) and 95% confidence intervals (CI) were obtained after allowance for major identified confounding factors, including total energy intake. Compared to the lowest quintile, the OR of prostate cancer for the highest quintile of total fibre intake was 0.93 (95% CI 0.71-1.22). The risk was inversely related with soluble fibre (OR = 0.89, 95% CI 0.78-1.02, for a difference between 80th and 20th percentile), cellulose (OR = 0.88, 95% CI 0.78-1.01) and vegetable fibre (OR = 0.82, 95% CI 0.73-0.93). These relationships were consistent across strata of age, family history of prostate cancer, body mass index and education. Vegetable fibres appear, therefore, to have a favourable association with prostate cancer risk.
authors.affiliation: Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. pelucchi@marionegri.it
authors.forename: Claudio
authors.initials: C
authors.lastname: Pelucchi
authors.forename: Renato
authors.initials: R
authors.lastname: Talamini
authors.forename: Carlotta
authors.initials: C
authors.lastname: Galeone
authors.forename: Eva
authors.initials: E
authors.lastname: Negri
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
authors.forename: Luigino
authors.initials: L
authors.lastname: Dal Maso
authors.forename: Maurizio
authors.initials: M
authors.lastname: Montella
authors.forename: Ettore
authors.initials: E
authors.lastname: Conti
authors.forename: Carlo
authors.initials: C
authors.lastname: La Vecchia
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D004043:Dietary Fiber / Q000008:administration & dosage*; D004522:Educational Status; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011467:Prostate / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000235:genetics / Q000517:prevention & control*; D012307:Risk Factors