Efficacy of nociceptin inhibition on WDR neuron activity is enhanced in mononeuropathic rats.
Nociceptin (NC), administered microiontophoretically at different concentrations, significantly reduced the spontaneous and stimulus-evoked activity on WDR neuron in rats with chronic constriction of one sciatic nerve and showing signs of neuropathic pain. The effect was not antagonized by Naloxone. The same concentrations of NC were ineffective on the noxious stimulus evoked responses of WDR neurons in sham and intact rats. This result indicates a facilitated inhibitory action of NC on nociceptive transmission in this pain model.
Sotgiu
Maria Luisa
ML
Istituto Bioimmagini e Fisiologia Molecolare, CNR, Via Fratelli Cervi 93, 20090 Segrate (Mi), Italy. maria.luisa.sotgiu@ibfm.cnr.it
Bellomi
Paola
P
Biella
Gabriele E M
GE
D000818:Animals; D003251:Constriction, Pathologic; D004594:Electrophysiology; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology*; D018847:Opioid Peptides / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000473:pathology; D014665:Vasodilator Agents / Q000494:pharmacology*; D000097629:Nociceptin
D009270:Naloxone; D009292:Narcotic Antagonists; D018847:Opioid Peptides; D014665:Vasodilator Agents; D000097629:Nociceptin