Marie Stopes Society, Pakistan: 1000 cases of quinacrine sterilization (QS).
To evaluate the safety, efficacy and acceptability of QS in Karachi, Pakistan.



1000 women who had chosen sterilization during the 4-year period 1994 to 1997 inclusive were offered QS at both stationary clinics and in a mobile van at 23 sites in the outskirts of Karachi. The protocol involved transcervical insertion to the uterine fundus of 252 mg quinacrine in 7 pellets and 55 mg of ibuprofen in 3 pellets through an IUD inserter, during the proliferative phase of the menstrual cycle. Two doses were administered one month apart. A temporary method of contraception was provided for 3 cycles, usually DMPA. Follow-up was scheduled: monthly for 3 months, quarterly for 1 year and then every 6 months for 4 years.



The crude pregnancy rate after 4 years was 2.0%. Minor complications and complaints were reported by 59% of the patients. There was one ectopic pregnancy and no major complications.



QS was found to be safe and effective and has become the most popular method of sterilization in our area of Pakistan.
Bilgrami
M
M
Marie Stopes Society, Karachi, Pakistan.
Shah
L
L
D000554:Ambulatory Care Facilities; D016861:Cyclooxygenase Inhibitors / Q000008:administration & dosage*; D004343:Drug Implants; D005187:Fallopian Tubes / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007047:Hysterosalpingography; D007052:Ibuprofen / Q000008:administration & dosage*; D008952:Mobile Health Units; D010154:Pakistan; D011247:Pregnancy; D011796:Quinacrine / Q000008:administration & dosage*; D012102:Reproductive Control Agents / Q000008:administration & dosage*; D012955:Societies, Medical; D013246:Sterilization, Tubal
D016861:Cyclooxygenase Inhibitors; D004343:Drug Implants; D012102:Reproductive Control Agents; D011796:Quinacrine; D007052:Ibuprofen