title: Multilocus genotyping of Pneumocystis jirovecii in patients developing diverse forms of parasitism: implication for a wide human reservoir for the fungus.
abstract: Pneumocystis jirovecii ITS and DHPS genotypes were identified in 3 patient groups developing diverse forms of P. jirovecii infections: 13 patients with Pneumocystis pneumonia, 8 patients merely colonized by the fungus, and 19 immunocompetent infants with bronchiolitis developing mild P. jirovecii infection. Common P. jirovecii genotypes were found in the 3 patient groups, suggesting that common sources of P. jirovecii were involved in the fungus acquisition, and that transmission cycles of P. jirovecii infections in these patient groups are not independent. Parasitized patients, whatever the form of parasitism they present, may be part of a common reservoir for P. jirovecii.
authors.affiliation: Department of Parasitology, Mycology and Travel Medicine, University Hospital, University of Picardy, 80054 Amiens, France, EU. annetotet@yahoo.fr
authors.forename: Anne
authors.initials: A
authors.lastname: Totet
authors.forename: Sophie
authors.initials: S
authors.lastname: Latouche
authors.forename: Hyacinthe
authors.initials: H
authors.lastname: Duwat
authors.forename: Eline
authors.initials: E
authors.lastname: Magois
authors.forename: Philippe
authors.initials: P
authors.lastname: Lacube
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Pautard
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Schmit
authors.forename: Vincent
authors.initials: V
authors.lastname: Jounieaux
authors.forename: Patricia
authors.initials: P
authors.lastname: Roux
authors.forename: Christian
authors.initials: C
authors.lastname: Raccurt
authors.forename: Gilles
authors.initials: G
authors.lastname: Nevez
mesh_terms: D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002874:Chromosome Mapping; D004197:Disease Reservoirs; D005260:Female; D005602:France; D005798:Genes, Bacterial / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D045363:Pneumocystis carinii / Q000235:genetics* / Q000302:isolation & purification; D011020:Pneumonia, Pneumocystis / Q000382:microbiology* / Q000635:transmission