[Effect of cinnarizine on the brain mitochondrial oxidative system, antioxidant blood activity, and the rat behavior in hypoxia].
The effect of cinnarizine on the functional state of brain mitochondria, the activity of blood antioxidant system, and the behavior of rats was studied under model hypoxic hypoxia conditions. A four-day treatments with cinnarizine (50 mg/kg, twice per day via a gastric tube) prevents the hypoxic brain edema development, restores NAD+ dependent oxidation of a succinate substrate, normalizes emotional-exploratory activity, and causes hyperlocomotion of the experimental animals, while not influencing a high level of activity of the blood antioxidant system.
Belostotskaia
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National Scientific Center for Drugs, Astronomicheskaya ul. 33, 61085 Kharkov, Ukraine.
Chaĭka
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Gomon
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ON
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001522:Behavior, Animal / Q000187:drug effects*; D001769:Blood / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D001929:Brain Edema / Q000209:etiology / Q000473:pathology; D002936:Cinnarizine / Q000494:pharmacology*; D000860:Hypoxia / Q000150:complications / Q000378:metabolism* / Q000523:psychology; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats
D000975:Antioxidants; D002936:Cinnarizine