title: Parallel nucleic acid recognition by the LNA (locked nucleic acid) stereoisomers beta-L-LNA and alpha-D-LNA; studies in the mirror image world.
abstract: Two LNA (locked nucleic acid) stereoisomers (beta-L-LNA and alpha-D-LNA) are evaluated in the mirror-image world, that is by the study of two mixed sequences of LNA and alpha-L-LNA and their L-DNA and L-RNA complements. Both are found to display high-affinity RNA-recognition by the formation of duplexes with parallel strand orientation.
authors.affiliation: Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, DK-5230 Odense, Denmark.
authors.forename: Nanna K
authors.initials: NK
authors.lastname: Christensen
authors.forename: Torsten
authors.initials: T
authors.lastname: Bryld
authors.forename: Mads D
authors.initials: MD
authors.lastname: Sørensen
authors.forename: Khalil
authors.initials: K
authors.lastname: Arar
authors.forename: Jesper
authors.initials: J
authors.lastname: Wengel
authors.forename: Poul
authors.initials: P
authors.lastname: Nielsen
mesh_terms: D001483:Base Sequence; D002942:Circular Dichroism; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; C477371:locked nucleic acid; D012313:RNA