Application of a latent class analysis to empirically define eating disorder phenotypes.
BACKGROUND
Diagnostic criteria for eating disorders influence how we recognize, research, and treat eating disorders, and empirically valid phenotypes are required for revealing their genetic bases.


OBJECTIVE
To empirically define eating disorder phenotypes.


METHODS
Data regarding eating disorder symptoms and features from 1179 individuals with clinically significant eating disorders were submitted to a latent class analysis. The resulting latent classes were compared on non-eating disorder variables in a series of validation analyses.


METHODS
Multinational, collaborative study with cases ascertained through diverse clinical settings (inpatient, outpatient, and community).


METHODS
Members of affected relative pairs recruited for participation in genetic studies of eating disorders in which probands met DSM-IV-TR criteria for anorexia nervosa (AN) or bulimia nervosa and had at least 1 biological relative with a clinically significant eating disorder. Main Outcome Measure Number and clinical characterization of latent classes.


RESULTS
A 4-class solution provided the best fit. Latent class 1 (LC1) resembled restricting AN; LC2, AN and bulimia nervosa with the use of multiple methods of purging; LC3, restricting AN without obsessive-compulsive features; and LC4, bulimia nervosa with self-induced vomiting as the sole form of purging. Biological relatives were significantly likely to belong to the same latent class. Across validation analyses, LC2 demonstrated the highest levels of psychological disturbance, and LC3 demonstrated the lowest.


CONCLUSIONS
The presence of obsessive-compulsive features differentiates among individuals with restricting AN. Similarly, the combination of low weight and multiple methods of purging distinguishes among individuals with binge eating and purging behaviors. These results support some of the distinctions drawn within the DSM-IV-TR among eating disorder subtypes, while introducing new features to define phenotypes.
Keel
Pamela K
PK
Department of Psychology, Harvard University, Cambridge, MA, USA. pamela-keel@uiowa.edu
Fichter
Manfred
M
Quadflieg
Norbert
N
Bulik
Cynthia M
CM
Baxter
Mark G
MG
Thornton
Laura
L
Halmi
Katherine A
KA
Kaplan
Allan S
AS
Strober
Michael
M
Woodside
D Blake
DB
Crow
Scott J
SJ
Mitchell
James E
JE
Rotondo
Alessandro
A
Mauri
Mauro
M
Cassano
Giovanni
G
Treasure
Janet
J
Goldman
David
D
Berrettini
Wade H
WH
Kaye
Walter H
WH
D000293:Adolescent; D000328:Adult; D001835:Body Weight; D003937:Diagnosis, Differential; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005247:Feeding Behavior; D001068:Feeding and Eating Disorders / Q000145:classification* / Q000175:diagnosis / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D015233:Models, Statistical; D009771:Obsessive-Compulsive Disorder / Q000145:classification / Q000523:psychology; D010641:Phenotype; D012680:Sensitivity and Specificity