Molecular cloning and characterization of the polymorphic MHC class II DBB from the tammar wallaby (Macropus eugenii).
Genes of the major histocompatibility complex (MHC) have been characterized in all extant lineages of mammals. The tammar wallaby (Macropus eugenii) is well established as a model marsupial species; however, no classical MHC sequences have been described from this species. We have isolated two MHC class II beta-chain sequences from a tammar wallaby spleen cDNA library using a tammar MHC class II beta probe. These sequences belong to the marsupial MHC class II DBB gene family. Two additional DBB sequences were amplified from tammar wallaby genomic DNA. All four sequences were obtained from the same individual, indicating that there are at least two DBB loci in the tammar wallaby.
Browning
Teena L
TL
Department of Biological Sciences, Macquarie University, 2109 Sydney, NSW, Australia.
Belov
Katherine
K
Miller
Robert D
RD
Eldridge
Mark D B
MD
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D007614:Macropodidae / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D011110:Polymorphism, Genetic; D017434:Protein Structure, Tertiary
D000949:Histocompatibility Antigens Class II