[Study on the expression of C-erbB-2 gene in coal miners with pneumoconiosis complicated by pulmonary cancer].
OBJECTIVE
To study the difference in the expressions of C-erbB-2 gene between the coal miners with pneumoconiosis complicated by pulmonary cancer and the controls with single pulmonary cancer, and its relation to clinical pathology.


METHODS
Measuring the expressions of C-erbB-2 in 32 cases of pneumoconiosis complicated by pulmonary cancer and those in 30 cases of pulmonary cancer by means of immunohistochemistry.


RESULTS
The positive expression rate in 32 cases of pneumoconiosis complicated by pulmonary cancer was 53.13% whereas that in 30 cases of single pulmonary cancer was 26.67% (P < 0.05); the positive expressions of C-erbB-2 in patients with lymph node metastasis (70.59% in pneumoconiosis group, 50.00% in controls) were significantly different from those without lymph node metastasis (33.33% in pneumoconiosis group, 11.11% in controls) (P < 0.05). The prognosis on patients with positive expressions of C-erbB-2 was poor, and was not related to pathologic category.


CONCLUSIONS
C-erbB-2 gene may be an important regulating gene in the coal miners with pneumoconiosis complicated by pulmonary cancer, and as a reference index to determine lymph node metastasis and prognosis.
Peng
Jun-hua
JH
Central Hospital of Mining Group, Zaozhuang, Shandong Province 277011, China.
Zhu
Chuan-dan
CD
Shen
Yong-lai
YL
Xu
Wen-shou
WS
Zhang
Tai-ke
TK
Hou
Hong-mei
HM
Sun
Jing
J
D000368:Aged; D002681:China; D003032:Coal Mining; D015870:Gene Expression; D018734:Genes, erbB-2; D005838:Genotype; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011009:Pneumoconiosis / Q000150:complications / Q000235:genetics* / Q000473:pathology; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism; D016019:Survival Analysis
D018719:Erb-b2 Receptor Tyrosine Kinases