title: [Sudden death of twins: botulism because of contamination by pap vegetables].
abstract: Botulism is caused by the blockage of the neural transmission in the cholinergic synapses by botulinum neurotoxin (BoNT) which is produced by Clostridium botulinum or other Clostridia. The classic form of botulism occurs after the ingestion of food contaminated by BoNT. The course of the infection can be asymptomatic, mild with subtle paralysis ("failure to thrive") oder severe with generalized paralysis ("floppy infant"). Infected infants can also die sudden and unexpectedly. These deaths often are attributed to Sudden Infant Death Syndrome (SIDS), unless a thorough postmortem examination reveals Botulism. The rate of fatal Botulism falsely attributed to SIDS is not known, because it is difficult in most cases to show the causal relationship between contamination, disease and death. We report the sudden and unexpected simultaneous death of twins of 22 months which could be attributed to Botulism. Contamination of food, colonization of the gut by Clostridia and infection with specific pathomorphological changes could be proven. The initial suspicion of infanticide could be excluded. lt could be shown, that Botulism is a potential cause of simultaneous unexpected deaths in twins.
authors.affiliation: Zentrum für Kinderheilkunde, Otto-von-Guericke-Universität Magdeburg, Magdeburg.
authors.forename: D
authors.initials: D
authors.lastname: Fischer
authors.forename: A
authors.initials: A
authors.lastname: Freislederer
authors.forename: G
authors.initials: G
authors.lastname: Jorch
mesh_terms: D001905:Botulinum Toxins / Q000633:toxicity; D001906:Botulism / Q000150:complications* / Q000473:pathology / Q000635:transmission; D002423:Cause of Death; D016360:Clostridioides difficile; D003937:Diagnosis, Differential; D004200:Diseases in Twins; D005243:Feces / Q000382:microbiology; D005260:Female; D005506:Food Contamination; D006801:Humans; D007223:Infant; D007225:Infant Food / Q000382:microbiology*; D007413:Intestinal Mucosa / Q000382:microbiology / Q000473:pathology; D007420:Intestine, Large / Q000382:microbiology / Q000473:pathology; D007421:Intestine, Small / Q000382:microbiology / Q000473:pathology; D013398:Sudden Infant Death / Q000209:etiology* / Q000473:pathology; D014675:Vegetables / Q000382:microbiology*
chemical_list: D001905:Botulinum Toxins