From the messenger RNA saga to the transcriptome era.
This review attempts to provide an overview of the evolution of the ideas and techniques that prevailed at the beginning of research on ribonucleic acids, until the contemporary era of cellular transcript analysis using DNA biochips and microarrays. Certain applications derived from the use of microarrays and the corresponding analyses of transcriptomes are discussed, particularly concerning diagnosis and prevision of evolution of certain cancers.
Gros
François
F
Académie des sciences, 23, quai de Conti, 75006 Paris, France. zajdman@academie-sciences.fr
D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D005821:Genetic Techniques; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger; D014158:Transcription, Genetic
D018076:DNA, Complementary; D012333:RNA, Messenger