title: Canine prostatic intraepithelial neoplasia: is the comparative model relevant?
abstract: BACKGROUND
  Histologic sections from an archival collection of a veterinary teaching hospital were examined to determine the likelihood of detection of canine high-grade prostatic intraepithelial neoplasms (HGPIN), as a prelude to use of the canine model of prostatic carcinogenesis for chemopreventive strategies.
  
  
  METHODS
  Tissue specimens representing clinically healthy (normal) prostate glands, benign prostatic hyperplasia, and prostatic carcinoma were examined in one tissue plane for histological evidence of HGPIN.
  
  
  RESULTS
  No histological evidence of HGPIN was detected in 20 normal prostate glands or 95 prostate glands with benign prostatic hyperplasia. Seven of 20 prostatic carcinomas had synchronous HGPIN.
  
  
  CONCLUSIONS
  Histological evidence of HGPIN is unlikely to be detected in the healthy or hyperplastic canine prostate gland with the clinically-procured biopsy. This might diminish the usefulness of canine HGPIN in temporal studies of chemoprevention of prostate cancer. HGPIN was found simultaneously with prostatic carcinoma in more than one-third of the carcinomas examined.
authors.affiliation: Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA. brmadewell@ucdavis.edu
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Madewell
authors.forename: Regina
authors.initials: R
authors.lastname: Gandour-Edwards
authors.forename: Ralph W
authors.initials: RW
authors.lastname: DeVere White
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D008297:Male; D019048:Prostatic Intraepithelial Neoplasia / Q000473:pathology / Q000662:veterinary*; D011471:Prostatic Neoplasms / Q000473:pathology / Q000662:veterinary*