Polycomb group proteins in cell cycle progression and cancer.
Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.
Pasini
Diego
D
Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
Bracken
Adrian P
AP
Helin
Kristian
K
D000818:Animals; D015153:Blotting, Western; D002453:Cell Cycle; D002455:Cell Division; D002843:Chromatin / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins; D004330:Drosophila; D005786:Gene Expression Regulation; D020868:Gene Silencing; D006367:HeLa Cells; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000378:metabolism*; D063151:Polycomb Repressive Complex 2; D063146:Polycomb-Group Proteins; D011233:Precipitin Tests; D011506:Proteins / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors
D002843:Chromatin; D004268:DNA-Binding Proteins; D063146:Polycomb-Group Proteins; D011506:Proteins; D034741:RNA, Small Interfering; D012097:Repressor Proteins; D014157:Transcription Factors; D004247:DNA; C103523:EZH1 protein, human; D063151:Polycomb Repressive Complex 2