title: Differentiation of idiopathic Parkinson's disease, multiple system atrophy, progressive supranuclear palsy, and healthy controls using magnetization transfer imaging.
abstract: The differentiation of multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) from idiopathic Parkinson's disease (IPD) is difficult. Magnetization transfer imaging (MTI), a measure that correlates with myelination and axonal density, was employed in this study in the attempt to distinguish between these disorders. Measurements were carried out in 15 patients with IPD, 12 patients with MSA, 10 patients with PSP, and in 20 aged-matched healthy control subjects. The main finding was a change in the magnetization transfer ratio in the globus pallidus, putamen, caudate nucleus, substantia nigra, and white matter in IPD, MSA, and PSP patients, matching the pathological features of the underlying disorder. Furthermore, stepwise linear discriminant analysis provided a good classification of the individual patients into the different disease groups. All IPD patients and control subjects were correctly separated from the MSA and PSP cohort, and all PSP patients and 11 of 12 MSA patients were correctly separated from the IPD and control cohort. There was also a fairly good discrimination of IPD patients from control subjects and of MSA from PSP patients. In conclusion, MTI revealed degenerative changes in patients with different parkinsonian syndromes matching the underlying pathological features of the different diseases, underlining the high potential of this method in distinguishing MSA and PSP from IPD.
authors.affiliation: Department of Neurology II, University of Magdeburg, 39120, Magdeburg, Germany. eckert@neuro2.med.uni-magdeburg.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Eckert
authors.forename: Michael
authors.initials: M
authors.lastname: Sailer
authors.forename: Joern
authors.initials: J
authors.lastname: Kaufmann
authors.forename: Christoph
authors.initials: C
authors.lastname: Schrader
authors.forename: Thomas
authors.initials: T
authors.lastname: Peschel
authors.forename: Nils
authors.initials: N
authors.lastname: Bodammer
authors.forename: Hans Jochen
authors.initials: HJ
authors.lastname: Heinze
authors.forename: Mircea Ariel
authors.initials: MA
authors.lastname: Schoenfeld
mesh_terms: D000368:Aged; D001369:Axons / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D002421:Caudate Nucleus / Q000473:pathology; D015331:Cohort Studies; D003937:Diagnosis, Differential; D005260:Female; D005917:Globus Pallidus / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000175:diagnosis*; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009415:Nerve Net / Q000473:pathology; D010300:Parkinson Disease / Q000175:diagnosis*; D011699:Putamen / Q000473:pathology; D012016:Reference Values; D012680:Sensitivity and Specificity; D013378:Substantia Nigra / Q000473:pathology; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis*