Oximidine III, a new antitumor antibiotic against transformed cells from Pseudomonas sp. II. Structure elucidation.
The structure of oximidine III, a new antitumor antibiotic against transformed cells from Pseudomonas sp. QN05727, was determined to be a benzolactone enamide containing an O-methyloxime moiety as shown in Fig. 1 by NMR spectral analysis including a variety of two-dimensional techniques.
Hayakawa
Yoichi
Y
Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0032, Japan. hayakawa@iam.u-tokyo.ac.jp
Tomikawa
Taijiro
T
Shin-ya
Kazuo
K
Arao
Nakako
N
Nagai
Koji
K
Suzuki
Ken-ichi
K
Furihata
Kazuo
K
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D015394:Molecular Structure; D011549:Pseudomonas
D000903:Antibiotics, Antineoplastic; D004852:Epoxy Compounds; D007783:Lactones; C482071:oximidine III