Rewiring the transcriptional regulatory circuits of cells.
The molecular mechanisms that regulate gene expression can evolve either by changing the cis-acting DNA elements in promoters, or by replacing the trans-acting regulatory proteins. New data from yeast species show that both processes can happen.
Scannell
Devin R
DR
Department of Genetics, Smurfit Institute, University of Dublin, Trinity College, Dublin 2, Ireland.
Wolfe
Ken
K
D002176:Candida albicans / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D020218:Response Elements; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
D014157:Transcription Factors