A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam.
The deposition of tau inclusions is one of the neuropathological hallmarks in neurodegenerative disorders with dementia. We have reported that the N-terminal fragment of a human granin-like neuroendocrine peptide precursor (N-proSAAS) is accumulated in Pick bodies. However, it is unknown whether N-proSAAS is widely accumulated in tau inclusions in other tauopathies. Here, we performed an immunohistochemical examination using antibodies against both the N- and C-terminal sequence of proSAAS in the brains of patients with Alzheimer's disease and parkinsonism-dementia complex on Guam. The antibody against N-proSAAS immunostained neurofibrillary tangles and neuritic plaques in both diseases, whereas the antibody against the C-terminal sequence of proSAAS did not. The results of the present study suggest that N-proSAAS or proSAAS-like molecules were trapped within the tau fibrils and accumulated in tau inclusions.
Wada
Manabu
M
Third Department of Internal Medicine, Yamagata University School of Medicine, Yamagata 990-9585, Japan. mwada@yacht.ocn.ne.jp
Ren
Chang-Hong
CH
Koyama
Shingo
S
Arawaka
Shigeki
S
Kawakatsu
Shinobu
S
Kimura
Hideki
H
Nagasawa
Hikaru
H
Kawanami
Toru
T
Kurita
Keiji
K
Daimon
Makoto
M
Hirano
Asao
A
Kato
Takeo
T
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D003704:Dementia / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006141:Guam; D006624:Hippocampus / Q000737:chemistry / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000737:chemistry / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009479:Neuropeptides / Q000032:analysis*; D020734:Parkinsonian Disorders / Q000378:metabolism* / Q000473:pathology; D010446:Peptide Fragments / Q000378:metabolism; D011498:Protein Precursors / Q000032:analysis*; D051381:Rats; D016875:tau Proteins / Q000032:analysis*
D009479:Neuropeptides; C403532:PCSK1N protein, human; D010446:Peptide Fragments; D011498:Protein Precursors; D016875:tau Proteins