title: Nail involvement in leprosy: a study of 300 patients.
abstract: Three hundred leprosy patients were recruited to study the pattern and frequency of nail changes. Nail changes, like longitudinal ridging in finger nails, transverse striations involving both finger and toe nails etc. which occurred with similar frequency in the PB and MB patients in comparison with the control group, were excluded from the analysis. Out of a total number of 150 PB patients, 84 (56%) showed nail changes. Fifty-eight (38.6%) patients showed changes in the finger nails, with an average of 3.2 involved nails per patient. Fifty-three (35.3%) patients showed changes in the toe nails, with an average of 3.0 nails per patient. The most common change observed was longitudinal melanonychia (32.4%) in the finger nails and longitudinal ridging (46.3%) in the toe nails.In comparison, 131/150 (87.3%) MB patients showed nail changes. Finger nail changes were seen in 102 (68%) patients with an average of 5.5 nails affected per patient. Changes in toe nails were seen in 116 (77.3%) patients, with an average of 6.0 nails involved per patient. The most common nail change observed was longitudinal melanonychia in 89/523, (17%) of the total involved finger nails and subungual hyperkeratosis in 164/702, (23.4%) of the total toe nails involvement. Out of a total of 32 colony patients, 31 (96.9%) showed nail changes both in finger and toe nails with an average of 7.9 and 8.4 affected nails per patient, respectively. The most common nail change observed was rudimentary nail(s) on fingers (29%) and toes (21.1%). Among MB patients, a significantly higher number had finger nail involvement in LL group. The frequency of nail involvement for both fingers and toes was significantly greater in LL as compared to BL group of patients. The frequency of nail involvement was significantly more in patients having disease for more than 5 years and in those having trophic changes secondary to loss of sensations and impaired circulation.
authors.affiliation: Department of Dermatology, Venereology & Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. kaur_inderjeet@yahoo.com
authors.forename: Inderjeet
authors.initials: I
authors.lastname: Kaur
authors.forename: Aditi
authors.initials: A
authors.lastname: Chakrabarti
authors.forename: Sunil
authors.initials: S
authors.lastname: Dogra
authors.forename: Ranju
authors.initials: R
authors.lastname: Rai
authors.forename: Bhushan
authors.initials: B
authors.lastname: Kumar
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D004359:Drug Therapy, Combination; D005385:Fingers / Q000473:pathology; D006801:Humans; D006987:Hypesthesia / Q000473:pathology; D007194:India / Q000453:epidemiology; D007917:Leprostatic Agents / Q000627:therapeutic use; D007918:Leprosy / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology; D008875:Middle Aged; D009260:Nail Diseases / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D009262:Nails / Q000098:blood supply / Q000473:pathology; D016491:Peripheral Vascular Diseases / Q000150:complications; D013997:Time Factors; D014034:Toes / Q000473:pathology
chemical_list: D007917:Leprostatic Agents