[Anatomical and functional abnormalities of central nervous system in autistic disorder: a MRI and SPECT study].
We present a study of anatomical and functional abnormalities of central nervous system (CNS) from patients with autistic disorder (AD); magnetic resonance imaging (MRI) and single photon emission computed tomography (SPECT) were used for the investigation. The population studied was composed of 24 patients, 15 (62.5%) males and 9 (17.5%) females, mean age 9 years. MRI was performed in all patients and SPECT was performed in 19 patients; 75% (n=18) of patients had anatomical abnormalities and all patients that realized SPECT had functional abnormalities. Anatomical abnormalities were preferentially noted in corpus callosum (25%), septum pellucidum (15.63%), cerebral ventricles (12.55%), cerebellum (9.38%), temporal lobes (6.25%), occipital lobes (6.25%) and hippocampus (6.25%). Functional abnormalities predominated in frontal lobes (53.13%), temporal lobes (28.13%), parietal lobes (15.63%) and basal ganglia (3.13%). However, anatomical and functional abnormalities of CNS are not priorities for diagnosis, which should have always clinical validation.
Machado
Marbene Guedes
MG
Serviço de Neurologia, Hospital Universitário, Universidade Federal de Sergipe, Aracaju, SE, Brasil. marbenguedes@uol.com.br
Oliveira
Hélio Araújo
HA
Cipolotti
Rosana
R
Santos
Clara Augusta Garcia Moreno
CA
de Oliveira
Emanoella Faro
EF
Donald
Robert Moraes
RM
Krauss
Miriam Peres de Oliveira
MP
D000293:Adolescent; D000328:Adult; D061085:Agenesis of Corpus Callosum; D001321:Autistic Disorder / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000503:physiopathology; D001921:Brain / Q000002:abnormalities / Q000000981:diagnostic imaging* / Q000473:pathology*; D002531:Cerebellum / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015899:Tomography, Emission-Computed, Single-Photon