title: Moxifloxacin penetration in bronchial secretions of mechanically ventilated patients with pneumonia.
abstract: The pharmacokinetics of moxifloxacin was studied in 17 mechanically ventilated patients with pneumonia. Patients were given 400 mg of moxifloxacin intravenously. Blood samples and bronchial secretions were taken on days 1 and 4. A dose of 400 mg of moxifloxacin allows one to achieve efficient concentrations in bronchial secretions and plasma.
authors.affiliation: Department of Anesthesiology and Intensive Care Unit and Trauma Center, Nord Hospital, Marseilles, France. leonem@msnotes.wustl.edu
authors.forename: Marc
authors.initials: M
authors.lastname: Leone
authors.forename: Jacques
authors.initials: J
authors.lastname: Albanèse
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Sampol-Manos
authors.forename: Nicolas
authors.initials: N
authors.lastname: Simon
authors.forename: Bruno
authors.initials: B
authors.lastname: Lacarelle
authors.forename: Bernard
authors.initials: B
authors.lastname: Bruguerolle
authors.forename: Claude
authors.initials: C
authors.lastname: Martin
mesh_terms: D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001372:Aza Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001980:Bronchi / Q000378:metabolism*; D005260:Female; D024841:Fluoroquinolones; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D000077266:Moxifloxacin; D011014:Pneumonia / Q000378:metabolism* / Q000628:therapy; D011804:Quinolines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D012121:Respiration, Artificial
chemical_list: D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D000077266:Moxifloxacin