title: The peritoneal route as a safe pathway for early in utero therapies: illustration by a 12-year follow-up after conservative management of severe Rhesus allo-immunization.
abstract: OBJECTIVE
  We report a case of an extremely severe Rhesus allo-immunization treated very early in pregnancy 12 years ago.
  
  
  RESULTS
  After chorionic villus sampling at 12 weeks for fetal blood phenotyping, two intraperitoneal transfusions at 14 and 15 weeks were given followed by two intravascular and seven exchange transfusions. A girl weighing 2,940 g was delivered vaginally at term after external cephalic version for breech presentation. To date her neurological and social development is normal.
  
  
  CONCLUSIONS
  Since the success of haematopoietic stem cell transplantations for the treatment of congenital haematologic diseases could imply early and repetitive procedures, this observation enlightens the technical feasibility of such an invasive approach and its relative safety for subsequent development.
authors.affiliation: Unité de Médecine Materno-Foetale, Maternité de l'Hôtel-Dieu, Clermont-Ferrand, France.
authors.forename: D
authors.initials: D
authors.lastname: Gallot
authors.forename: N
authors.initials: N
authors.lastname: Boiret
authors.forename: P
authors.initials: P
authors.lastname: Vanlieferinghen
authors.forename: H
authors.initials: H
authors.lastname: Laurichesse
authors.forename: J C
authors.initials: JC
authors.lastname: Micorek
authors.forename: M
authors.initials: M
authors.lastname: Berger
authors.forename: D
authors.initials: D
authors.lastname: Lemery
mesh_terms: D000328:Adult; D001805:Blood Transfusion, Intrauterine / Q000379:methods*; D015193:Chorionic Villi Sampling / Q000379:methods / Q000706:statistics & numerical data; D019468:Disease Management; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007263:Infusions, Parenteral / Q000379:methods; D011247:Pregnancy; D012203:Rh Isoimmunization / Q000175:diagnosis / Q000628:therapy*