Inactivation of transmissible spongiform encephalopathy (prion) agents by environ LpH.
Agents causing transmissible spongiform encephalopathy (TSE) diseases are resistant to inactivation by several conventional decontamination methods. Using an animal bioassay, we compared the TSE agent disinfectant efficacy of a commercially available product referred to alternatively as LpH-SE, LpH-AG, or LpH-st to that of a similarly named but differently formulated product, Environ LpH, which was found to be an effective TSE agent disinfectant in a previous study. Here, we found LpH-SE to be at least 10(4)-fold to 10(5)-fold less effective than Environ LpH.
Race
Richard E
RE
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA. rrace@niaid.nih.gov
Raymond
Gregory J
GJ
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006224:Cricetinae; D006018:Glycols / Q000737:chemistry / Q000494:pharmacology*; D008647:Mesocricetus; D017096:Prion Diseases / Q000378:metabolism* / Q000517:prevention & control; D011328:Prions / Q000187:drug effects* / Q000472:pathogenicity; D020005:Propanols / Q000737:chemistry / Q000494:pharmacology*
C482265:Environ LpH; D006018:Glycols; D011328:Prions; D020005:Propanols