title: Anxiolytic-like effects of rose oil inhalation on the elevated plus-maze test in rats.
abstract: The effect of rose oil inhalation (1.0%, 2.5%, and 5.0% w/w) on the elevated plus-maze (EPM) test was investigated in adult male rats and compared with the effect of diazepam (DZP) (1.0 and 2.0 mg/kg) administered intraperitoneally 30 min before testing. Exposure to rose oil produced an anxiolytic-like effect similar to DZP (anxiolytic reference drug). Thus, at some concentrations, rose oil significantly increased the number of visits to and time spent in the open arms of the EPM. Anxiolytic-like properties of rose oil were observed using the EPM, being consistent with other behavioral and clinical studies.
authors.affiliation: Department of Physiology and Pathology/LTF, Universidade Federal da Paraíba-Caixa, P.O. Box 5009, PB 58051-970, João Pessoa, Brazil. reinaldoan@uol.com.br
authors.forename: Reinaldo Nóbrega
authors.initials: RN
authors.lastname: de Almeida
authors.forename: Simone Cristina
authors.initials: SC
authors.lastname: Motta
authors.forename: Claudia
authors.initials: C
authors.lastname: de Brito Faturi
authors.forename: Bruna
authors.initials: B
authors.lastname: Catallani
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Leite
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001007:Anxiety / Q000523:psychology*; D003975:Diazepam / Q000494:pharmacology; D007274:Injections, Intraperitoneal; D008297:Male; D010938:Plant Oils / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D027826:Rosa / Q000737:chemistry*
chemical_list: D014151:Anti-Anxiety Agents; D010938:Plant Oils; D003975:Diazepam