title: Comparative study of two portable systems for oral anticoagulant monitoring.
abstract: Portable prothrombin time (PT) monitors offer the potential for both simplifying and improving oral anticoagulation management. It is necessary to evaluate their concordance and correlation with other PT systems. Our objective was to evaluate the concordance and clinical correlation of two portable PT determination systems, ProTime (ITC) and CoaguChek S (Roche Diagnostics). In all, 20 healthy individuals and 60 anticoagulated patients stabilized over 3 months in a therapeutic International Normalized Ratio (INR) range between 2-3.5 were studied. A drop of capillary blood was obtained simultaneously from two different fingers of each patient and applied to the monitor's application zone. The mean INR of the patients' blood samples of the two monitors differed by 0.01 units (2.32+/-0.63 for Pro Time and 2.33+/-0.68 for CoaguChek). The percentage of simple concordance and the kappa index were 88.3 and 75.9%, respectively. The coefficient of correlation was 0.922. The mean difference (bias) between the monitors was 0.01. The portable PT monitors evaluated presented a high percentage of concordance in INR results.
authors.affiliation: FIDEC- Fundación para la Investigación y Docencia de las Enfermedades Cardiovasculares. bdbvarim@lg.ehu.es
authors.forename: Marta
authors.initials: M
authors.lastname: Vacas
authors.forename: Pedro José
authors.initials: PJ
authors.lastname: Lafuente
authors.forename: Iciar
authors.initials: I
authors.lastname: Unanue
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Iriarte
mesh_terms: D000284:Administration, Oral; D000925:Anticoagulants / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016903:Drug Monitoring / Q000379:methods*; D006801:Humans; D019934:International Normalized Ratio; D019095:Point-of-Care Systems; D011517:Prothrombin Time / Q000295:instrumentation*; D015203:Reproducibility of Results
chemical_list: D000925:Anticoagulants