title: Serotonin modulation of cerebral glucose metabolism in normal aging.
abstract: Age-related alterations in serotonin function may increase the vulnerability to psychiatric and neurodegenerative disorders in late life. The neuroendocrine and cerebral metabolic response to the acute administration of the selective serotonin reuptake inhibitor, citalopram (40mg, IV), was measured in 17 normal control subjects using positron emission tomography (PET) to evaluate changes in serotonin function with normal aging. The citalopram-induced change in cerebral metabolism was positively correlated with age in the right precuneus, right paracentral lobule, and left middle temporal gyrus and negatively correlated with age in the left anterior cingulate gyrus, right inferior and middle frontal gyri, right insula, and right inferior parietal lobule. The positive correlations in mainly posterior brain regions indicate that normal aging is associated with an increase in metabolism after citalopram administration, whereas the negative correlations in mainly anterior brain regions indicate that normal aging is associated with a greater decrease in metabolism. These results suggest different compensatory processes in anterior compared to posterior brain regions secondary to the age-related loss of serotonin innervation.
authors.affiliation: Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, 75-59 263rd Street, Glen Oaks, NY 11004, USA.
authors.forename: Sara
authors.initials: S
authors.lastname: Goldberg
authors.forename: Gwenn S
authors.initials: GS
authors.lastname: Smith
authors.forename: Anna
authors.initials: A
authors.lastname: Barnes
authors.forename: Yilong
authors.initials: Y
authors.lastname: Ma
authors.forename: Elisse
authors.initials: E
authors.lastname: Kramer
authors.forename: Kimberly
authors.initials: K
authors.lastname: Robeson
authors.forename: Margaret
authors.initials: M
authors.lastname: Kirshner
authors.forename: Bruce G
authors.initials: BG
authors.lastname: Pollock
authors.forename: David
authors.initials: D
authors.lastname: Eidelberg
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000378:metabolism*; D015283:Citalopram / Q000494:pharmacology; D005260:Female; D007839:Functional Laterality / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D012701:Serotonin / Q000378:metabolism*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D013223:Statistics as Topic; D013997:Time Factors; D014055:Tomography, Emission-Computed / Q000379:methods
chemical_list: D015283:Citalopram; D005947:Glucose; D006854:Hydrocortisone; D011388:Prolactin; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors