title: Relationship between liver injury and transglutaminase activities in guinea pigs and rats.
abstract: We investigated the effect of transglutaminase (TGase) on in guinea pigs and rats. Serum alanine aminotransferase (ALT) level increased 1 d after CCl(4) treatment of both in guinea pigs and rats since TGaese activity was greatly higher in guinea pigs than rats. However, serum ALT level in guinea pigs was very much lower than that in rats. Liver TGase activities decreased after CCl(4) treatment in both guinea pigs and rats. However, TGase activities in the liver from guinea pigs were higher than that from rats. Decreased TGase activities by CCl(4) in the liver from guinea pigs and rats were significantly recovered by retinoic acid treatment that was reported to increase TGase. Degree of recovery of serum ALT level by retinoic acid in rats was larger than in guinea pigs. These results suggested that the distinction of the effect of retinoic acid on serum ALT level in CCl(4)-treated animals was due to the different TGase activity that increased membrane stability.
authors.affiliation: Department of Radiopharmacy, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan. n-sato@tohoku-pharm.ac.jp
authors.forename: Naoko
authors.initials: N
authors.lastname: Sato
authors.forename: Shinya
authors.initials: S
authors.lastname: Abe
authors.forename: Takehito
authors.initials: T
authors.lastname: Yamada
authors.forename: Koichi
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Ohtake
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Ohkubo
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology* / Q000209:etiology; D006168:Guinea Pigs; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D011503:Transglutaminases / Q000378:metabolism*; D014212:Tretinoin / Q000494:pharmacology
chemical_list: D014212:Tretinoin; D011503:Transglutaminases; D000410:Alanine Transaminase