title: [Dry eye in graft-versus-host disease].
abstract: OBJECTIVE
  To investigate patients who had ocular presentations after allogeneic hematopoietic stem cell transplantation.
  
  
  METHODS
  The eyes of 20 patients of leukemia who had undergone allogeneic hematopoietic stem cell transplantation were examined. The ocular surface of these patients was examined by slit-lamp. The eye examination also included evaluation of tear break-up time, Schirmer tests with and without nasal stimulation, and fluorescein staining, rose bengal staining, etc. Conjunctival impression cytology and pathological examination of surgical specimens from 3 patients were performed.
  
  
  RESULTS
  Fourteen of 20 patients developed chronic graft-versus-host disease (cGVHD). Eight patients suffered from dry eye accompanied by GVHD simultaneously. The incidence of dry eye in GVHD was 57%. Among them, 4 cases were severe dry eye associated with significant decrease of visual acuity and even development of corneal ulcer. Ophthalmic pathology findings were as follows: loss of conjunctival goblet cells or significant reduction in amount; conjunctival and corneal epithelial keratinization and squamous metaplasia; and dominance of T cell in conjunctival inflammatory infiltration cells.
  
  
  CONCLUSIONS
  Dry eye is the major ocular complication after allogeneic hematopoietic stem cell transplantation. It affected the patients' life quality severely. The high incidence and potentially severe ocular problems in these patients suggest that close ophthalmic monitoring is important in allogeneic hematopoietic stem cell transplantation.
authors.affiliation: Zhongshan Ophthalmic Center, Zhongshan University, Guangzhou 510060, China.
authors.forename: Wen-lei
authors.initials: WL
authors.lastname: Fei
authors.forename: Jia-qi
authors.initials: JQ
authors.lastname: Chen
authors.forename: Xin
authors.initials: X
authors.lastname: Du
authors.forename: Yan-hui
authors.initials: YH
authors.lastname: Liu
authors.forename: Ming-xia
authors.initials: MX
authors.lastname: Sun
authors.forename: Jian-xian
authors.initials: JX
authors.lastname: Lin
authors.forename: Jian-yu
authors.initials: JY
authors.lastname: Weng
authors.forename: Tian-zhen
authors.initials: TZ
authors.lastname: Luo
authors.forename: Dong-ming
authors.initials: DM
authors.lastname: Yin
authors.forename: Xiao-yang
authors.initials: XY
authors.lastname: Luo
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D015352:Dry Eye Syndromes / Q000209:etiology*; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications* / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous