title: [Evaluation of the reliability of three different hepatitis E diagnosis reagents on the clinical acute hepatitis E].
abstract: OBJECTIVE
  To evaluate the reliability of different hepatitis E diagnosis reagent tests on the acute hepatitis E.
  
  
  METHODS
  Three acute hepatitis E diagnosis tests, E2-IgM (Wantai, China), GL-IgM and GL-IgG (Genelabs, Singapore) were compared for their reliability in a sera panel composed by 273 healthy individuals and 525 hepatitis.
  
  
  RESULTS
  The specificity of E2-IgM on the diagnosis of acute hepatitis E was 100.0%, it was significantly higher than GL-IgM (96.7%) and GL-IgG (85.4%). The sensitivity of E2-IgM and GL-IgG were 97.9% and 93.8% respectively, both significantly higher than GL-IgM (72.9%). Among 65 acute hepatitis cases being positive on GL-IgM test but negative on E2-IgM, 58 (89.2%) cases were found to be positive with anti-hepatitis A virus IgM, it indicated that the GL-IgM test might be interfered by other IgM antibodies on serum.
  
  
  CONCLUSIONS
  E2-IgM is a good test for the diagnosis of acute hepatitis E.
authors.affiliation: The Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen University, Xiamen 361005, China.
authors.forename: Ying-jie
authors.initials: YJ
authors.lastname: Zheng
authors.forename: Qing-wu
authors.initials: QW
authors.lastname: Jiang
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhao
authors.forename: Sheng-xiang
authors.initials: SX
authors.lastname: Ge
authors.forename: Mei-yang
authors.initials: MY
authors.lastname: Gao
authors.forename: Jian
authors.initials: J
authors.lastname: Lin
authors.forename: Shang-hai
authors.initials: SH
authors.lastname: Ou
authors.forename: Ning-shao
authors.initials: NS
authors.lastname: Xia
mesh_terms: D000208:Acute Disease; D006508:Hepatitis Antibodies / Q000097:blood; D016751:Hepatitis E / Q000175:diagnosis*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity
chemical_list: D006508:Hepatitis Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011933:Reagent Kits, Diagnostic