title: Expression of vascular endothelial growth factor and prognosis of oral squamous cell carcinoma.
abstract: The correlation between expression of vascular endothelial growth factor (VEGF) and prognosis for oral squamous cell carcinoma was investigated. Tissue samples of oral squamous cell carcinoma were obtained from 63 patients. Of these patients, 11 had stage I, 17 had stage II, 9 had stage III, and 26 had stage IV tumours. Immunohistochemical expression of VEGF was quantitatively determined by computer-assisted image analysis. The value of VEGF expression was significantly higher for the patients with poor prognosis than for those with good prognosis (P=0.0423). Regarding regional lymph node metastasis, VEGF showed no significant difference between metastasis positive and negative patients. Expression of VEGF may thus be a prognostic marker for oral squamous cell carcinoma.
authors.affiliation: Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto, Japan. uehara@net.nagasaki-u.ac.jp
authors.forename: Masataka
authors.initials: M
authors.lastname: Uehara
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sano
authors.forename: Hisazumi
authors.initials: H
authors.lastname: Ikeda
authors.forename: Joji
authors.initials: J
authors.lastname: Sekine
authors.forename: Akihiko
authors.initials: A
authors.lastname: Irie
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Yokota
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Tobita
authors.forename: Seigo
authors.initials: S
authors.lastname: Ohba
authors.forename: Tsugio
authors.initials: T
authors.lastname: Inokuchi
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D009363:Neoplasm Proteins / Q000378:metabolism; D009367:Neoplasm Staging; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D042461:Vascular Endothelial Growth Factor A