A case of generalized pustular psoriasis associated with Turner syndrome.
We report a 27-year-old Japanese woman with Turner syndrome who had generalized pustular psoriasis of the von Zumbusch type. She developed a febrile diffuse erythema and pustular eruption without any history of preceding psoriasis vulgaris or drug ingestion. Oral treatment with 3.2 mg/kg cyclosporin per day successfully resulted in rapid improvement, followed by a complete remission. To our knowledge, this is the first report describing the unusual coexistence of these two systemic disorders. We discuss a hormone imbalance that might have contributed to the predisposition to pustular psoriasis and difficulties in the management of the patent's treatment.


BACKGROUND
TS: Turner syndrome, GPP: generalized pustular psoriasis
Kawakami
Yoshio
Y
Department of Dermatology, Fukushima Medical University School of Medicine, Fukushima, Japan.
Oyama
Noritaka
N
Kishimoto
Kazuhiro
K
Yamazaki
Keiji
K
Nishibu
Akiko
A
Nakamura
Koichiro
K
Hoshi
Satoshi
S
Kaneko
Fumio
F
D000328:Adult; D001707:Biopsy, Needle; D016572:Cyclosporine / Q000008:administration & dosage; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D011565:Psoriasis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014424:Turner Syndrome / Q000150:complications* / Q000175:diagnosis
D016572:Cyclosporine