title: Validation of a chiral HPLC assay for (R)-salbutamol sulfate.
abstract: A fast, reliable and specific method for the screening, confirmation, determination and quantitation of salbutamol enantiomers was developed and validated. The described procedure includes a single robust chiral HPLC determination employing a Teicoplanin stationary phase. The method was evaluated for specificity, robustness, linearity, precision and accuracy. Under the chromatographic conditions of the method, known impurities were separated from the active principle.
authors.affiliation: Agencia Córdoba Ciencia, Unidad CEPROCOR, Alvarez de Arenales 230, 5000 Córdoba, Argentina.
authors.forename: Alejandra
authors.initials: A
authors.lastname: Halabi
authors.forename: Carlos
authors.initials: C
authors.lastname: Ferrayoli
authors.forename: Marcela
authors.initials: M
authors.lastname: Palacio
authors.forename: Viviana
authors.initials: V
authors.lastname: Dabbene
authors.forename: Sara
authors.initials: S
authors.lastname: Palacios
mesh_terms: D000420:Albuterol / Q000032:analysis* / Q000737:chemistry / Q000592:standards; D002851:Chromatography, High Pressure Liquid / Q000379:methods / Q000592:standards; D013237:Stereoisomerism
chemical_list: D000420:Albuterol