Pathological effects on mice by gambierol, possibly one of the ciguatera toxins.
Gambierol was isolated from Gambierdiscus toxicus, which causes ciguatera fish poisoning. The acute toxicological effects induced in mice by synthesized gambierol were studied. The lethal doses were about 80 microg/kg by i.p. and i.v., and 150 microg/kg by p.o. The main injury by this toxin was observed in the lung, and secondary in the heart, resulting in systemic congestion. Another toxic effect was seen in the stomach, inducing hypersecretion and ulceration. With survival from the severe stage during the initial 3 h, recovery was favorable, especially after 4 days. Additional effects were not evident during 1-week post-administration observation.
Ito
Emiko
E
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8673, Japan. emiko@faculty.chiba-u.jp
Suzuki-Toyota
Fumie
F
Toshimori
Kiyotaka
K
Fuwa
Haruhiko
H
Tachibana
Kazuo
K
Satake
Masayuki
M
Sasaki
Makoto
M
D000284:Administration, Oral; D000818:Animals; D036841:Ciguatera Poisoning; D002922:Ciguatoxins / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D004141:Dinoflagellida; D004195:Disease Models, Animal; D004988:Ethers, Cyclic / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009206:Myocardium / Q000473:pathology; D011083:Polycyclic Compounds / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D035964:Oxocins
D002922:Ciguatoxins; D004988:Ethers, Cyclic; D011083:Polycyclic Compounds; C435770:gambierol; D035964:Oxocins