Hedgehog signaling: Costal-2 bridges the transduction gap.
Drosophila genetics has provided the Hedgehog signaling pathway with roughly ordered components, but few mechanistic connections. Several studies now show that the kinesin-related protein Costal-2 provides a physical link between the transmembrane transducer Smoothened and the transcriptional effector Cubitus interruptus.
Kalderon
Daniel
D
Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D004330:Drosophila / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism*; D053823:Hedgehog Proteins; D016547:Kinesins / Q000378:metabolism*; D008954:Models, Biological; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D015398:Signal Transduction; D000072086:Smoothened Receptor; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D043562:Receptors, G-Protein-Coupled; D000072086:Smoothened Receptor; D014157:Transcription Factors; C092937:ci protein, Drosophila; C107452:cos protein, Drosophila; C100664:smo protein, Drosophila; C077245:hh protein, Drosophila; D016547:Kinesins