title: Semantic knowledge of famous people in mild cognitive impairment and progression to Alzheimer's disease.
abstract: Patients with dementia of Alzheimer's type (DAT) show severe impairment in recognizing famous people. The aim of the current study was to investigate if this well-known memory impairment of famous faces is already present in the preclinical phase of DAT and if the famous faces test can help to differentiate patients with mild cognitive impairment (MCI) who progress to dementia and those who do not. We compared baseline performance in a task of famous face identification in a sample of 116 patients with subjective memory complaints classified in three groups: 17 participants with no evidence of cognitive impairment; 26 patients with MCI who had not developed dementia, and 27 patients with MCI who had developed probable DAT 2 years later. The remaining patients were excluded because they abandoned or did not meet the applied restrictive criteria for DAT, MCI or control. MCI patients who were diagnosed 2 years later with DAT performed significantly worse in the preclinical phase than MCI and control participants (p < 0.004). Patients with MCI but not DAT obtained intermediate results between control subjects and MCI patients who develop Alzheimer's disease. A neuropsychological task of semantic knowledge of famous people may be useful in the early diagnosis of Alzheimer's disease.
authors.affiliation: Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain. 20389aeg@comb.es
authors.forename: Armando
authors.initials: A
authors.lastname: Estévez-González
authors.forename: Carmen
authors.initials: C
authors.lastname: García-Sánchez
authors.forename: Anunciación
authors.initials: A
authors.lastname: Boltes
authors.forename: Pilar
authors.initials: P
authors.lastname: Otermín
authors.forename: Berta
authors.initials: B
authors.lastname: Pascual-Sedano
authors.forename: Alex
authors.initials: A
authors.lastname: Gironell
authors.forename: Jaime
authors.initials: J
authors.lastname: Kulisevsky
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000523:psychology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000523:psychology*; D003937:Diagnosis, Differential; D018450:Disease Progression; D005197:Famous Persons; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000175:diagnosis / Q000523:psychology; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D012307:Risk Factors