SMXA-5 mouse as a diabetic model susceptible to feeding a high-fat diet.
The SMXA-5 strain, a new mouse model for type 2 diabetes, is a recombinant inbred strain derived from non-diabetic SM/J and A/J strains. As dietary fat is a key component in the development of diabetes, we compared the glucose tolerance and diabetes-related traits among the SMXA-5, SM/J, and A/J strains while feeding a high-fat diet for 10 weeks. SMXA-5 fed on a high-fat diet showed an increased serum insulin concentration. Judging from the hyperinsulinemia in SMXA-5, this strain showed insulin resistance, an inability of peripheral tissues to respond to insulin, which was strengthened by feeding with a high-fat diet. When fed on a high-fat diet for 5 weeks, the SMXA-5 mice showed severely impaired glucose tolerance. On the other hand, SM/J showed mildly impaired glucose tolerance, even when fed on a high-fat diet for 10 weeks. These results indicate that SMXA-5 would be available for use as a diabetic model susceptible to a high-fat diet.
Kobayashi
Misato
M
Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University.
Io
Fusayo
F
Kawai
Takahiro
T
Nishimura
Masahiko
M
Ohno
Tamio
T
Horio
Fumihiko
F
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology*; D004041:Dietary Fats / Q000494:pharmacology*; D004195:Disease Models, Animal; D005951:Glucose Tolerance Test; D006943:Hyperglycemia / Q000209:etiology; D007328:Insulin / Q000097:blood; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000235:genetics; D011995:Recombination, Genetic
D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin