Effects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammation.
The aging process is associated with various morphological and biochemical changes in the nervous system that may affect the processing of noxious inputs. This study showed greater hyperalgesia and up-regulation of spinal dynorphin (DYN) expression in aging than in young adult rats during CFA-induced peripheral inflammation. These data indicate that nociception is regulated differently in aging individuals, a fact that should be considered when selecting treatment strategies for aging populations with persistent pain.
Zhang
Rui-Xin
RX
Center for Integrative, 3rd Floor, James Kernan Hospital Mansion, 2200 Kernan Drive, School of Medicine, University of Maryland, Baltimore, MD 21207, USA. Rzhan001@umaryland.edu
Lao
Lixing
L
Qiao
Jian-Tian
JT
Ruda
M A
MA
D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D004399:Dynorphins / Q000235:genetics / Q000378:metabolism*; D005620:Freund's Adjuvant; D007839:Functional Laterality / Q000502:physiology; D006930:Hyperalgesia / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D007150:Immunohistochemistry; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000378:metabolism* / Q000503:physiopathology; D010812:Physical Stimulation; D020671:Posterior Horn Cells / Q000378:metabolism*; D011498:Protein Precursors / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D015854:Up-Regulation / Q000502:physiology
D011498:Protein Precursors; D012333:RNA, Messenger; C036448:pre-prodynorphin; D004399:Dynorphins; D005620:Freund's Adjuvant