title: Large segment allograft survival is improved with intramedullary cement.
abstract: OBJECTIVE
  The most common cause of failure in large segment bone allografts used for oncologic reconstruction is allograft fracture. Reinforcement with pressurized intramedullary cement may improve the mechanical properties of allografts.
  
  
  METHODS
  We reviewed the prospectively collected records of 45 patients who underwent en bloc resection of an extremity bone tumor and reconstruction using an allograft with intramedullary cement.
  
  
  RESULTS
  Seven allografts were used for arthrodesis, 20 were intercalary, and 18 were osteochondral. Twenty eight of 45 patients were alive at a mean 5.8 years (SD 1.9; range 3-11.2) with 24 allografts in situ. In these 45 patients, there were four allograft fractures and four infections. Six of these complications resulted in allograft removal. The estimated 5-year allograft survival rate was 86% (95% confidence interval 74-98%). Seven patients required secondary autogenous bone grafting for non-unions. Function measured by the Toronto Extremity Salvage Score and the 1987 and 1993 Musculoskeletal Tumor Society Rating Scales demonstrated a consistent pattern with worse function in patients with osteochondral allografts and best function with intercalary allografts.
  
  
  CONCLUSIONS
  These results suggest the addition of intramedullary cement to large segment bone allografts improves their survival by decreasing the fracture risk, particularly for allografts used for arthrodesis and intercalary reconstructions.
authors.affiliation: North of England Bone and Soft Tissue Tumour Service, Newcastle-Upon-Tyne, United Kingdom.
authors.forename: Craig H
authors.initials: CH
authors.lastname: Gerrand
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Griffin
authors.forename: Aileen M
authors.initials: AM
authors.lastname: Davis
authors.forename: Allan E
authors.initials: AE
authors.lastname: Gross
authors.forename: Robert S
authors.initials: RS
authors.lastname: Bell
authors.forename: Jay S
authors.initials: JS
authors.lastname: Wunder
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001174:Arthrodesis; D001843:Bone Cements / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000601:surgery*; D016025:Bone Transplantation; D005260:Female; D050723:Fractures, Bone / Q000601:surgery; D006801:Humans; D008297:Male; D020366:Methylmethacrylate / Q000627:therapeutic use*; D008875:Middle Aged; D019637:Orthopedic Procedures / Q000379:methods*; D011446:Prospective Studies; D019651:Plastic Surgery Procedures; D020127:Recovery of Function; D014184:Transplantation, Homologous
chemical_list: D001843:Bone Cements; D020366:Methylmethacrylate