Plakolide A, a new gamma-lactone from the marine sponge Plakortis sp.
Plakolide A (1), a new alpha-exomethylene-gamma-lactone isolated from the marine sponge Plakortis sp., was found to inhibit inducible nitric oxide synthase (iNOS) activity. The isolation, structure elucidation, and biological activity of plakolide A is described.
Gunasekera
Sarath P
SP
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U.S. 1 North, Fort Pierce, FL 34946, USA. sgunaseker@hboi.edu
Isbrucker
Richard A
RA
Longley
Ross E
RE
Wright
Amy E
AE
Pomponi
Shirley A
SA
Reed
John K
JK
D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors*; D052247:Nitric Oxide Synthase Type II; D011161:Porifera / Q000737:chemistry*
D004791:Enzyme Inhibitors; D007783:Lactones; C483268:plakolide A; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II