[Expression of toll-like receptor mRNA in epithelial cell of nasal mucosa].
OBJECTIVE
To understand the expression of Toll-like receptor-2 (TLR-2) and Toll-like receptor-4 (TLR-4) in epithelial cell of nasal mucosa, and to investigate the role of Toll-like receptors in the innate immunity of nasal mucosa.


METHODS
Specimens from 30 patients with chronic sinusitis and 21 healthy adults were examined by in situ hybridization for TLR-2 and TLR-4 mRNA.


RESULTS
All 30, samples of chronic sinusitis showed a stranger expression of TLR-2 and TLR-4 than in controls (t = 8.605, P < 0.0005, t = 9.050, P < 0.0005).


CONCLUSIONS
It is suggested that epithelial in nasal mucosa were not just a physical barrier, which could represent a novel defense mechanism of the host during bacterial infections through Toll-like receptors.
Wang
Cheng-shuo
CS
Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Union Hospital of Jilin University, Changchun 130031, China.
Dong
Zhen
Z
D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D004847:Epithelial Cells / Q000378:metabolism*; D005260:Female; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D015398:Signal Transduction; D012852:Sinusitis / Q000378:metabolism*; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors
D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; C495342:TLR2 protein, human; C495345:TLR4 protein, human; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D051193:Toll-Like Receptors