title: Deep sedation for magnetic resonance imaging. Personal experience.
abstract: OBJECTIVE
  Precision in diagnostic procedure and examination of paediatric patients often requires their absolute immobility. Deep sedation has proven to be an excellent method, allowing optimum technical quality of MRI particularly in younger age groups. The aim of study is to demonstrate the possible application of deep sedation through the use of 2 safe and manageable drugs.
  
  
  METHODS
  We carefully evaluated and selected 82 patients (47 males and 35 females; average age 5.4 years): they came from various paediatrics departments. Deep sedation was practiced with: Chloral hydrate (60-80 mg/kg in one oral administration); propofol as intravenous bolus (2-2.5 mg/kg) followed by a maintenance infusion of 75-125 microg/kg/min. This was preceded by midazolam (0.05 mg/kg i.v.) outside the MRI room. Oxygen saturation (SpO2) was monitored in all patients along with heart rate in order to foresee the need for any possible therapeutic intervention.
  
  
  RESULTS
  The sedation levels attained permitted the success of MRI assuring the immobilization required. Manually assisted mask ventilation was required for a period of 2-3 min in 5 patients treated with propofol. All other patients breathed autonomously. Complete reawakening occurred within 2 hours of drug administration. Surveillance was prolonged inside their respective units, however, without registering delayed side effects.
  
  
  CONCLUSIONS
  The central point of the success of deep sedation is to define the type and dose of optimum drug for individual patients. This requires a qualified, expert group ready to intervene in the presence of adverse results of drugs administered. Propofol and chloral hydrate are the optimum drugs for diagnostic techniques requiring total immobilization and rapid reawakening.
authors.affiliation: Department of Anesthesiology and Resuscitation, University of Cagliari, Cagliari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Marchi
authors.forename: A
authors.initials: A
authors.lastname: Orrù
authors.forename: M E
authors.initials: ME
authors.lastname: Manai
authors.forename: C
authors.initials: C
authors.lastname: Chelo
authors.forename: B
authors.initials: B
authors.lastname: Lettieri
authors.forename: G G
authors.initials: GG
authors.lastname: Corbucci
mesh_terms: D002675:Child, Preschool; D002697:Chloral Hydrate; D016292:Procedural Sedation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015742:Propofol
chemical_list: D002697:Chloral Hydrate; D015742:Propofol