title: [Characteristics of pyrrolidone pharmacokinetics in rats].
abstract: The pharmacokinetics of pyrrolidone in a composition with pyroglutamic acid was studied in white mongrel male rats. The former component exhibits cerebrovascular and neuroprotector activity. Pyrrolidone, detected in the blood plasma and brain for 8 h after peroral and intravenous administration, exhibits a high absolute bioavailability and the ability to penetrate via the blood-brain barrier.
authors.affiliation: Laboratory of Pharmacokinetics, Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
authors.forename: A K
authors.initials: AK
authors.lastname: Sariev
authors.forename: E V
authors.initials: EV
authors.lastname: Lun'shina
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000378:metabolism; D007275:Injections, Intravenous; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D011760:Pyrrolidinones / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D014018:Tissue Distribution
chemical_list: D018696:Neuroprotective Agents; D011760:Pyrrolidinones