Multiple congenital anomalies associated with in utero exposure of phenytoin: possible hypoxic ischemic mechanism?
BACKGROUND
The characteristics of the phenotype of the malformed phenytoin-exposed infant can help to clarify the mechanism of the drug's teratogenesis. One postulated mechanism is vascular disruption.


METHODS
An infant who was exposed to phenytoin as monotherapy throughout pregnancy was born with the following abnormalities: midface hypoplasia, digit hypoplasia with syndactyly in the hands and feet, meningomyelocele, talipes equinovarus, and a long skin pedicle on the back. The mother was also exposed to cigarette smoking and alcohol during the pregnancy.


CONCLUSIONS
The malformations of the hands and feet, and the talipes deformity are potential effects of vascular disruption, a postulated fetal effect of both phenytoin and cigarette smoking. The mechanism of the teratogenicity of phenytoin may have included episodes of bradyarrhythmia in the fetus; however, no such episodes were documented.
Lyon
Helen M
HM
Children's Hospital, Boston, Massachusetts, USA.
Holmes
Lewis B
LB
Huang
Taosheng
T
D000014:Abnormalities, Drug-Induced; D000015:Abnormalities, Multiple / Q000209:etiology* / Q000503:physiopathology; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D005865:Gestational Age; D006801:Humans; D000860:Hypoxia / Q000209:etiology* / Q000503:physiopathology; D007231:Infant, Newborn; D007511:Ischemia / Q000209:etiology* / Q000503:physiopathology; D018811:Maternal Exposure; D010672:Phenytoin / Q000009:adverse effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy
D000927:Anticonvulsants; D010672:Phenytoin