title: Ventral cardiac denervation reduces the incidence of atrial fibrillation after coronary artery bypass grafting.
abstract: OBJECTIVE
  Because the autonomic nervous system is an important determinant in the appearance of atrial fibrillation, we have assessed the role of ventral cardiac denervation for its prevention.
  
  
  METHODS
  Patients undergoing low-risk coronary artery surgery were enrolled. No routine antiarrhythmic drugs were administered before or after the operation. Ventral cardiac denervation was performed in 207 patients, and 219 patients were used as control subjects. Denervation was performed before cardiopulmonary bypass. The groups were comparable regarding demographic, clinical, and operative variables.
  
  
  RESULTS
  The additional time for the denervation was 5 +/- 2 minutes, and there were no associated complications. Postoperative atrial fibrillation was present in 15 (7%) patients undergoing ventral cardiac denervation (95% confidence interval, 4%-12%) and in 56 (27%) control subjects (95% confidence interval, 18%-35%). Patients submitted to ventral cardiac denervation had fewer and less severe episodes of atrial fibrillation, and no patient had atrial fibrillation after discharge. Ventral cardiac denervation was the most significant predictor of postoperative atrial fibrillation (odds ratio, 0.42; confidence interval, 0.23-0.78; P =.006). Age of greater than 65 years (odds ratio, 1.67; confidence interval, 0.96-2.9; P =.067) was a highly suggestive predictor. The analysis of the effect of ventral cardiac denervation correlated with the patient's age showed a more pronounced effect in patients younger than 70 years (odds ratio, 0.43; confidence interval, 0.22-0.86; P =.022)
  
  
  CONCLUSIONS
  Ventral cardiac denervation is a fast and low-risk procedure. Its use significantly reduces the incidence and severity of atrial fibrillation after routine coronary artery bypass surgery. Patients younger than 70 years of age are expected to have a higher success rate than those older than 70 years.
authors.affiliation: Santa Cruz Hospital, Carnaxide, Portugal. jaomelo100@hotmail.com
authors.forename: João
authors.initials: J
authors.lastname: Melo
authors.forename: Peter
authors.initials: P
authors.lastname: Voigt
authors.forename: Bingur
authors.initials: B
authors.lastname: Sonmez
authors.forename: Manuel
authors.initials: M
authors.lastname: Ferreira
authors.forename: Miguel
authors.initials: M
authors.lastname: Abecasis
authors.forename: Maria
authors.initials: M
authors.lastname: Rebocho
authors.forename: Ana
authors.initials: A
authors.lastname: Timóteo
authors.forename: Carlos
authors.initials: C
authors.lastname: Aguiar
authors.forename: Selim
authors.initials: S
authors.lastname: Tansal
authors.forename: Harun
authors.initials: H
authors.lastname: Arbatli
authors.forename: Robert
authors.initials: R
authors.lastname: Dion
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000367:Age Factors; D000368:Aged; D000638:Amiodarone / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy*; D001026:Coronary Artery Bypass; D003714:Denervation; D004554:Electric Countershock; D005260:Female; D006321:Heart / Q000294:innervation*; D006329:Heart Conduction System / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D017052:Hospital Mortality; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy*; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012086:Reoperation; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists; D000889:Anti-Arrhythmia Agents; D000638:Amiodarone