title: Synthesis and antifungal activities of phenylenedithioureas.
abstract: A total of 20 new phenylenedithiourea derivatives was synthesized by reaction of phenylenediisothiocyanates with aromatic amines as aminobenzoic, aminosalicylic acid and their derivatives. Their chemical structures were confirmed by elemental analysis, IR spectrometry and 1H NMR. The compounds were screened for in vitro antifungal, antibacterial activities and some of them have strong antifungal activities comparable to the activity observed for ketoconazole.
authors.affiliation: Pharmaceutical Chemistry Department, Faculty of Pharmacy, HoChiMinh City Medicine and Pharmacy University, 41-43 DinhTienHoang Street, 1st District, HoChiMinh City, Viet Nam. phuongnq@hcm.ftp.vn
authors.forename: Truong
authors.initials: T
authors.lastname: Phuong
authors.forename: Thai
authors.initials: T
authors.lastname: Khac-Minh
authors.forename: Nguyen Thi
authors.initials: NT
authors.lastname: Van Ha
authors.forename: Huynh Thi
authors.initials: HT
authors.lastname: Ngoc Phuong
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D007654:Ketoconazole / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001555:Benzene Derivatives; D013890:Thiourea; D007654:Ketoconazole