Analysis of survivors more than 10 years after heart transplantation in the cyclosporine era: Stanford experience.
BACKGROUND
Truly long term survival post heart transplantation has become increasingly frequent over the past two decades.


METHODS
We analyzed multiple clinical outcomes in the cohort of 140 patients in the Stanford database who underwent heart transplantation after the introduction of cyclosporine-based immunosuppression in 1980 and survived >10 years after transplantation.


RESULTS
We found generally excellent functional status in these patients, but a high incidence of hypertension, renal dysfunction, and graft CAD as well as malignancy.


CONCLUSIONS
With continued improvement in post-transplant survival rates, providing complex care for such long-term recipients as these will assume increasing clinical importance in the everyday practice of transplant medicine and these data highlight the problems to be anticipated.
Shiba
Nobuyuki
N
Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, California 94305, USA.
Chan
Michael C Y
MC
Kwok
Bernard W K
BW
Valantine
Hannah A
HA
Robbins
Robert C
RC
Hunt
Sharon A
SA
D000328:Adult; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000453:epidemiology; D016572:Cyclosporine / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D016027:Heart Transplantation / Q000401:mortality*; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015994:Incidence; D008297:Male; D009369:Neoplasms / Q000453:epidemiology; D012042:Registries / Q000706:statistics & numerical data; D051437:Renal Insufficiency / Q000453:epidemiology; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors
D007166:Immunosuppressive Agents; D016572:Cyclosporine