A new indolizinone from Polygonatum kingianum.
A new indolizinone, namely kinganone (1) together with 3-ethoxymethyl-5,6,7,8-tetrahydro-8-indolizinone (2) and isomucronulatol (3) were isolated from the rhizome of Polygonatum kingianum. Their structures were elucidated mainly on the basis of spectral data. Indolizinones 1 and 2 showed weak antibacterial and antifungal activities when compared to rifampicin and amphotericin, respectively, in the agar diffusion assay.
Wang
Yi-Fen
YF
The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China.
Lu
Chun-Hua
CH
Lai
Guo-Fang
GF
Cao
Jian-Xin
JX
Luo
Shi-De
SD
D000666:Amphotericin B / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007212:Indolizines / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010407:Penicillium / Q000187:drug effects; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D031384:Polygonatum; D012293:Rifampin / Q000494:pharmacology
D000890:Anti-Infective Agents; D007212:Indolizines; D010936:Plant Extracts; C481299:kinganone; D000666:Amphotericin B; D012293:Rifampin