title: Short-term outcome of critically ill patients with severe acute respiratory syndrome.
abstract: OBJECTIVE
  To document the outcome and determine prognostic factors for patients with severe acute respiratory syndrome who require admission to an intensive care unit.
  
  
  METHODS
  Observational cohort study involving retrospective analysis of demographic, clinical, laboratory and radiological data.
  
  
  METHODS
  Adult intensive care unit in a tertiary referral university hospital involved in a major outbreak of severe acute respiratory syndrome (SARS).
  
  
  METHODS
  The first 54 patients admitted with SARS to an intensive care unit (ICU). All were treated with corticosteroids, ribavirin, broad spectrum antimicrobials and supportive therapy.
  
  
  METHODS
  None.
  
  
  RESULTS
  All patients were admitted for respiratory failure. The median APACHE II score was 11 (interquartile range 8-13). At 28 days 34 patients (63%; 95% CI 49.6-74.6) were alive and not mechanically ventilated. Six patients were alive but ventilated (11.3%; 95% confidence interval 5.3-22.6) and 14 had died (25.9%; CI 16.1-38.9). Seven of 27 ventilated patients developed evidence of barotrauma (25.9%; 95% CI 13.2-44.7). Median maximal multiple-organ dysfunction score was 5 (interquartile range 3.3-9). Median maximal respiratory dysfunction score was 3 (interquartile range 3-4). Increased age, severity of illness, lymphocyte count, decreased steroid dose, positive fluid balance, chronic disease or immunosuppression and nosocomial sepsis were associated with poor outcome on univariate analysis. Poor outcome was defined as death or need for mechanical ventilation at 28 days after ICU admission.
  
  
  CONCLUSIONS
  Mortality amongst critically ill patients with SARS is high. It causes predominantly severe respiratory failure, with little other organ failure, and a high incidence of barotrauma amongst those requiring mechanical ventilation.
authors.affiliation: Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, ROC. gomersall@cuhk.edu.hk
authors.forename: Charles D
authors.initials: CD
authors.lastname: Gomersall
authors.forename: Gavin M
authors.initials: GM
authors.lastname: Joynt
authors.forename: Philip
authors.initials: P
authors.lastname: Lam
authors.forename: Thomas
authors.initials: T
authors.lastname: Li
authors.forename: Florence
authors.initials: F
authors.lastname: Yap
authors.forename: Doris
authors.initials: D
authors.lastname: Lam
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Buckley
authors.forename: Joseph J Y
authors.initials: JJ
authors.lastname: Sung
authors.forename: David S
authors.initials: DS
authors.lastname: Hui
authors.forename: Gregory E
authors.initials: GE
authors.lastname: Antonio
authors.forename: Anil T
authors.initials: AT
authors.lastname: Ahuja
authors.forename: Patricia
authors.initials: P
authors.lastname: Leung
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006305:Health Status Indicators; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012121:Respiration, Artificial; D015656:Respiratory Mechanics; D012189:Retrospective Studies; D045169:Severe Acute Respiratory Syndrome / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy; D018709:Statistics, Nonparametric; D016896:Treatment Outcome