title: Cytotoxic diterpenoids from Isodon enanderianus.
abstract: Five new ent-kaurane diterpenoids, enanderianins K-O (1-5), and one new ent-abietane diterpenoid, enanderianin P (6), together with five known ent-kaurane diterpenoids, rabdocoetsin A (7), rabdocoetsin B (8), rabdocoetsin D (9), megathyrin A (10), megathyrin B (11) were isolated from the aerial parts of Isodon enanderianus. Their structures were determined by spectral means. Some diterpenoids were tested for their cytotoxicity against the human tumor K562 cells. Compounds 1, 2, 6, 8, 9 showed significant inhibitory activities against K562 cells with IC50 values ranging from 0.13 to 0.87 microg/mL.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Academia Sinica, Kunming, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Xiang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Na
authors.forename: Sheng-Hong
authors.initials: SH
authors.lastname: Li
authors.forename: Ma-Lin
authors.initials: ML
authors.lastname: Li
authors.forename: Rong-Tao
authors.initials: RT
authors.lastname: Li
authors.forename: Qin-E
authors.initials: QE
authors.lastname: Tian
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D037602:Isodon; D020014:K562 Cells / Q000187:drug effects; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D010936:Plant Extracts