Osteopontin identified as colon cancer tumor progression marker.
Identifying molecular markers for colon cancer is a top priority. Using a pooled sample approach with Affymetrix GeneChip technology, we assayed colon cancers derived from a series of clinical stages to identify molecular markers of potential prognostic value. Of 12000 genes assessed, osteopontin emerged as the leading candidate tumor progression marker. Osteopontin is a secreted glycoprotein known to bind integrins and CD44. Its actual molecular function remains elusive but its increased expression correlates strongly with tumor progression.
Agrawal
Deepak
D
Department of Cell Biology, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA.
Chen
Tingan
T
Irby
Rosalyn
R
Quackenbush
John
J
Chambers
Ann F
AF
Szabo
Marianna
M
Cantor
Alan
A
Coppola
Domenico
D
Yeatman
Timothy J
TJ
D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology*; D018450:Disease Progression; D006801:Humans; D053495:Osteopontin; D012313:RNA / Q000032:analysis; D012795:Sialoglycoproteins / Q000032:analysis* / Q000235:genetics
D014408:Biomarkers, Tumor; C506895:SPP1 protein, human; D012795:Sialoglycoproteins; D053495:Osteopontin; D012313:RNA