title: Exercise blood pressure is related to insulin resistance in subjects with two hypertensive parents.
abstract: BACKGROUND
  Insulin resistance has been implicated in the pathogenesis of essential hypertension. Elevated blood pressure during physical exercise is a more powerful predictor of future hypertension than resting blood pressure. We have therefore studied the relationship between insulin resistance and blood pressure response to exercise in strongly hypertension-prone subjects.
  
  
  METHODS
  Twenty-five normotensive subjects aged 18-35 years with bi-parental hypertension, and 26 matched controls with normotensive parents.
  
  
  METHODS
  (i) Maximal exercise tolerance test with continuous gas-exchange measurement; (ii) blood pressure at rest, during exercise and 24-h ambulatory; (iii) euglycemic hyperinsulinemic clamp.
  
  
  RESULTS
  Diastolic blood pressure during exercise was higher in hypertensionprone subjects as compared to controls, but only in subjects with low insulin sensitivity. Resting and 24-h diastolic blood pressure were higher in hypertension-prone subjects, but independent of insulin sensitivity level. Insulin sensitivity and exercise capacity were similar in the groups.
  
  
  CONCLUSIONS
  Diastolic blood pressure during exercise was higher in hypertension-prone subjects as compared to controls, but only in insulin-resistant subjects. Since elevated blood pressure during physical exertion is a predictor of future hypertension, these findings may suggest that insulin resistance is involved in the pathogenesis of essential hypertension.
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, Denmark. uandersen@dadlnet.dk
authors.forename: Ulrik B
authors.initials: UB
authors.lastname: Andersen
authors.forename: Michael H
authors.initials: MH
authors.lastname: Olsen
authors.forename: Harriet
authors.initials: H
authors.lastname: Dige-Petersen
authors.forename: Hans
authors.initials: H
authors.lastname: Ibsen
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D016022:Case-Control Studies; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005192:Family Health; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D010290:Parents; D011237:Predictive Value of Tests