Adenosine A2A receptor mRNA expression is increased in rat striatum and nucleus accumbens after memantine administration.
Quantitative in situ hybridization revealed a significant increase (23-43%) of A(2A) receptor mRNA levels 8-48 h after administration of memantine (25 mg/kg, i.p.) in the striatum and nucleus accumbens regions of rat brain. These results indicate an effect on adenosine A(2A) receptors at the molecular level by a NMDA receptor antagonist.
Marvanová
Markéta
M
A.I. Virtanen Institute, Department of Neurobiology, Laboratory of Functional Genomics and Bioinformatics, University of Kuopio, P.O. Box 1627, FIN-70211, Kuopio, Finland.
Wong
Garry
G
D000704:Analysis of Variance; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects*; D017403:In Situ Hybridization / Q000379:methods; D008297:Male; D008559:Memantine / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D009833:Olfactory Pathways / Q000187:drug effects; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D043705:Receptor, Adenosine A2A / Q000235:genetics / Q000378:metabolism*; D017447:Receptors, Dopamine D1 / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction / Q000379:methods; D013997:Time Factors
D018691:Excitatory Amino Acid Antagonists; D012333:RNA, Messenger; D043705:Receptor, Adenosine A2A; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D016291:Dizocilpine Maleate; D008559:Memantine