Postprandial lipemia is modified by the presence of the polymorphism present in the exon 1 variant at the SR-BI gene locus.
It has recently been reported that carriers of the less common allele at the scavenger receptor class B type I (SR-BI) exon 1 polymorphism are more susceptible to the presence of saturated fatty acid in the diet because of a greater increase in LDL cholesterol. Our aim was to determine if this polymorphism could also influence postprandial lipoprotein metabolism, because the SR-BI has been described as a possible mediator in the intestinal absorption of triacylglycerols. Forty-seven normolipidemic volunteers who were homozygous for the E3 allele at the APOE gene were selected [37 homozygous for the common genotype (1/1) at the SR-BI exon 1 polymorphism and 10 heterozygous (1/2)]. They were given a fat-rich meal containing 1 g fat and 7 mg cholesterol per kg body weight and vitamin A 60,000 IU/m2 body surface. Fat accounted for 60% of calories, and protein and carbohydrates accounted for 15% and 25% of energy respectively. Blood samples were taken at time 0, every 1 h until 6 h, and every 2.5 h until 11 h. Total cholesterol and triacylglycerols in plasma, and cholesterol, triacylglycerols and retinyl palmitate in triacylglycerol-rich lipoproteins (large and small triacylglycerol-rich lipoproteins) were determined. Postprandial responses for triacylglycerols and retinyl palmitate in small triacylglycerol-rich lipoproteins were higher in 1/1 individuals than in 1/2 individuals. No other significant differences were noted. Our data show that the presence of the genotype 1/2 is associated with a lower postprandial lipemic response.
Pérez-Martínez
P
P
Unidad de Lipidos y Arteriosclerosis, Hospital Universitario Reina Sofia, Córdoba, Spain.
López-Miranda
J
J
Ordovás
J M
JM
Bellido
C
C
Marín
C
C
Gómez
P
P
Paniagua
J A
JA
Moreno
J A
JA
Fuentes
F
F
Pérez-Jiménez
F
F
D000328:Adult; D018955:CD36 Antigens; D008078:Cholesterol, LDL / Q000032:analysis / Q000097:blood; D004041:Dietary Fats / Q000378:metabolism*; D004224:Diterpenes; D005227:Fatty Acids / Q000494:pharmacology; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008074:Lipoproteins / Q000032:analysis / Q000097:blood; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D019518:Postprandial Period / Q000502:physiology; D011971:Receptors, Immunologic / Q000235:genetics*; D051116:Receptors, Scavenger; D000084562:Retinyl Esters; D051122:Scavenger Receptors, Class B; D014280:Triglycerides / Q000032:analysis / Q000097:blood; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000494:pharmacology
D018955:CD36 Antigens; D008078:Cholesterol, LDL; D004041:Dietary Fats; D004224:Diterpenes; D005227:Fatty Acids; D008074:Lipoproteins; D011971:Receptors, Immunologic; D051116:Receptors, Scavenger; D000084562:Retinyl Esters; C495124:SCARB1 protein, human; D051122:Scavenger Receptors, Class B; D014280:Triglycerides; D014801:Vitamin A; C014794:retinol palmitate