High phosphorus diet changes phosphorus metabolism regardless of PTH action in rats.
In this study, we ascertained whether the parathyroid hormone (PTH) dominantly regulated the effects of high phosphorus (P) intakes on urinary excretion of P and bone metabolism in rats. To maintain serum PTH level equally, parathyroidectomy (PTX) and sham-operated rats were constantly exposed to rPTH(1-34) and fed both control (0.3% P) and high P (1.2% P) diet for 7 days, respectively. Urinary excretions of P and C-terminal telopeptides of type I collagen were significantly increased in both PTX and sham rats by the high P diet. These results suggest that high P diet increased urinary P excretion while promoting bone resorption regardless of PTH-dependent regulation.
Katsumata
Shin-Ichi
S
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture.
Masuyama
Ritsuko
R
Koshihara
Moyuru
M
Matsuzaki
Hiroshi
H
Uehara
Mariko
M
Suzuki
Kazuharu
K
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D004032:Diet; D004435:Eating / Q000187:drug effects; D008297:Male; D010281:Parathyroid Hormone / Q000378:metabolism*; D016105:Parathyroidectomy; D010446:Peptide Fragments / Q000097:blood / Q000494:pharmacology; D010758:Phosphorus / Q000378:metabolism* / Q000494:pharmacology* / Q000652:urine; D051381:Rats; D017208:Rats, Wistar; D019379:Teriparatide / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology
D010281:Parathyroid Hormone; D010446:Peptide Fragments; D019379:Teriparatide; D010758:Phosphorus; C035748:parathyroid hormone (1-34)amide