B cells in multiple sclerosis.
The most common laboratory abnormality in multiple sclerosis (MS) is an increased amount of cerebrospinal fluid IgG and the presence of oligoclonal bands. Despite studies of the humoral response that suggest the involvement of an infectious agent or autoantigen in disease, the major targets of the oligoclonal response are still unknown. Identification of these targets will reveal valuable insights into the cause and pathogenesis of MS and is likely to lead to effective treatment.
Burgoon
Mark P
MP
Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA. mark.burgoon@uchsc.edu
Gilden
Donald H
DH
Owens
Gregory P
GP
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology* / Q000473:pathology
D001323:Autoantibodies