title: Verrucous hyperplasia of the great toe: a case and a review of the literature.
abstract: BACKGROUND
  Verrucous hyperplasia is a hyperplastic disease that manifests as coalescent warty papules at stump amputation sites. Often overlooked, it can be confused with verrucous carcinoma. As such, it is of concern for dermatologic surgeons.
  
  
  OBJECTIVE
  To present a patient with verrucous hyperplasia and review its literature.
  
  
  METHODS
  We report a 62-year-old diabetic patient with a verrucous nodule that arose at the amputation site of her first three right toes. Despite repeated surgical removals and skin graftings, the verrucous nodule redeveloped. A biopsy revealed digitate epidermal hyperplasia with dilated tortuous capillaries in thin dermal papilla without invasive features, mitotic figures, or acanthotic downgrowth. Polymerase chain reaction did not detect human papilloma virus.
  
  
  RESULTS
  Verrucous hyperplasia secondary to amputation was diagnosed.
  
  
  CONCLUSIONS
  Verrucous hyperplasia occurs should not be confused with verrucous carcinoma or warts. Moreover, because it recurs after removal, surgery is not indicated; rather, compression therapy is indicated.
authors.affiliation: Department of Dermatology, St. Luke's-Roosevelt Hospital Center, New York, New York 10025, USA. scheinfeld@earthlink.net
authors.forename: Noah
authors.initials: N
authors.lastname: Scheinfeld
authors.forename: Thomas
authors.initials: T
authors.lastname: Yu
authors.forename: Jin
authors.initials: J
authors.lastname: Lee
mesh_terms: D000671:Amputation, Surgical; D018289:Carcinoma, Verrucous / Q000175:diagnosis; D017719:Diabetic Foot / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D010212:Papilloma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014034:Toes; D014860:Warts / Q000175:diagnosis