title: First synthesis of an amythiamicin pyridine cluster.
abstract: The pyridine-containing central domain of the amythiamicin group of thiopeptide antibiotics is prepared in protected form in 9 steps, 93%ee and 18% overall yield from (S)-2-[1-(tert-butoxycarbonylamino)-2-methylpropyl]thiazole-4-carboxylic acid by Michael addition-cyclodehydration of a 2-(2-thiazolyl)enamine and 1-(2-thiazolyl)propynone.
authors.affiliation: School of Chemistry, Cardiff University, PO Box 912, Cardiff, UKCF10 3TB. bagleymc@cf.ac.uk
authors.forename: Mark C
authors.initials: MC
authors.lastname: Bagley
authors.forename: James W
authors.initials: JW
authors.lastname: Dale
authors.forename: Robert L
authors.initials: RL
authors.lastname: Jenkins
authors.forename: Justin
authors.initials: J
authors.lastname: Bower