title: [Bone mineral density in school age children born preterm ].
abstract: BACKGROUND
  The age at which children born preterm normalize their bone mineral density, is not well known.
  
  
  OBJECTIVE
  To study if children born preterm have normalized their bone mineral density at age 5 to 7 years.
  
  
  METHODS
  Twenty six infants born preterm (14 male), were studied at age 5 to 7 years. Birth weight, present weight and height, bone age, calcium and phosphate intake at the first year of life and at the current age were assessed. Bone mineral density was measured by single photon X ray absorptiometry in the dominant forearm. A blood sample was obtained to measure insulin growth factor 1 (IGF-1). As a control group, 105 healthy age-paired infants born at term, were studied.
  
  
  RESULTS
  Bone mineral density was significantly lower in infants born preterm than in their term counterparts (0.273 +/- 0.01 g/cm2 and 0.302 +/- 0.01 g/cm2 respectively, p < 0.001). There was a positive correlation between bone mineral density and IGF-1 (r = 0.49, p = 0.01). No correlation with the other measured parameters was observed.
  
  
  CONCLUSIONS
  Infants that were born preterm have a lower bone mineral density at 5 to 7 years of age than their term controls. Bone mineral density correlates with IGF-1.
authors.affiliation: Departamentos de Pediatría y Medicina, Facultad de Medicina, Universidad de Valparaíso, Chile. pediatria@uv.cl
authors.forename: Aída
authors.initials: A
authors.lastname: Milinarsky
authors.forename: Sylvia
authors.initials: S
authors.lastname: Fischer
authors.forename: Vinka
authors.initials: V
authors.lastname: Giadrosich
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Hernández
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Torres
mesh_terms: D000886:Anthropometry; D001724:Birth Weight / Q000502:physiology*; D015519:Bone Density; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008297:Male; D018709:Statistics, Nonparametric