Momordica charantia extracts inhibit uptake of monosaccharide and amino acid across rat everted gut sacs in-vitro.
The inhibitory effects of Momordica charantia extracts were studied on the uptake of glucose and tyrosine across rat everted gut sacs in vitro. The aqueous extract of the plant was found to inhibit primarily the uptake of glucose in a dose-dependent manner. Uptake of tyrosine was affected at high substrate concentrations only. The extract was also found to decrease the absorptive capacity of fluid across the small intestine and sodium ions. It is hypothesized that the effects of Momordica could involve a washout of glucose from the blood stream.
Mahomoodally
Mohamad Fawzi
MF
Department of Health and Medical Sciences, Faculty of Science, University of Mauritius, Reduit, Mauritius.
Fakim
Ameenah-Gurib
AG
Subratty
Anwar Hussein
AH
D000596:Amino Acids / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D004305:Dose-Response Relationship, Drug; D005638:Fruit / Q000737:chemistry; D005947:Glucose / Q000037:antagonists & inhibitors / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D029777:Momordica charantia / Q000737:chemistry*; D009005:Monosaccharides / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000037:antagonists & inhibitors / Q000378:metabolism; D014443:Tyrosine / Q000378:metabolism; D014867:Water
D000596:Amino Acids; D007004:Hypoglycemic Agents; D009005:Monosaccharides; D010936:Plant Extracts; D014867:Water; D014443:Tyrosine; D012964:Sodium; D005947:Glucose; D011188:Potassium