Respiratory control during postural changes in anesthetized cats.
The effect of postural changes on respiration was investigated in ten anesthetized cats by applying body tilting during the inspiration phase while recording respiratory patterns, as given by the diaphragmatic EMG, together with either the lung volume or the air flow temperature. The results show that the head-up tilting during inspiration reduced the period of the inspiratory phase and increased the end-inspiratory lung volume. On the other hand, the head-down tilting during inspiration had opposite effects. These effects disappeared after transection of the vagus nerve. However, labyrinthectomy did not diminish the effects, probably because of functional suppression of the vestibular system due to the anesthetic. When correlating the activity of 15 vagal afferents presumably originating from the slowly adapting lung stretch receptors with lung volume changes during tilting, their maximum firing rate (87 +/- 15.7 Hz) was increased with an increase in the lung inflation volume and was attained earlier on head-up tilting and it was reduced with a decrease of the lung volume on head-down tilting (63 +/- 16.6 Hz) as compared with the value in the horizontal position (74 +/- 14.2 Hz). These results suggest that respiratory modulation during head-up or head-down tilting is consistent with the Hering-Breuer reflexes and minimizes the externally induced lung volume changes during postural changes.
Miyashita
Misao
M
Department of Physiology, Kyorin University School of Medicine, Shinkawa, Mitaka-shi, Tokyo 181-8611, Japan.
Suzuki-Inatomi
Takami
T
Hirai
Naoki
N
D000818:Animals; D001831:Body Temperature; D002415:Cats; D003964:Diaphragm / Q000502:physiology; D004576:Electromyography; D004594:Electrophysiology; D018475:Head-Down Tilt; D001239:Inhalation; D008168:Lung / Q000502:physiology; D008176:Lung Volume Measurements; D008465:Mechanoreceptors / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology; D011187:Posture / Q000502:physiology*; D012123:Pulmonary Ventilation; D012018:Reflex; D012143:Respiratory Physiological Phenomena; D013990:Tidal Volume; D014628:Vagotomy; D014630:Vagus Nerve / Q000166:cytology / Q000502:physiology