Tamoxifen optic neuropathy.
A 68-year-old woman with metastatic breast cancer presented with slowly progressive visual loss in each eye. Electrophysiology confirmed bilateral optic neuropathies. Investigations to determine the cause of the vision loss were negative. Cessation of tamoxifen resulted in a dramatic improvement in acuity.
Colley
Stephen M
SM
Elston
John S
JS
D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D005260:Female; D006801:Humans; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000503:physiopathology; D013629:Tamoxifen / Q000009:adverse effects*; D014792:Visual Acuity / Q000187:drug effects* / Q000502:physiology; D014794:Visual Fields / Q000187:drug effects
D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen