Unusual presentation of life-threatening Toscana virus meningoencephalitis.
This case report describes a brother and a sister with severe meningoencephalitis caused by Toscana virus (TOSv). The clinical presentation was characterized by stiff neck, deep coma, maculopapular rash, diffuse lymphadenopathy, hepatosplenomegaly, renal involvement, tendency to bleeding, and diffuse intravascular coagulation. The boy had epididymo-orchitis. Recovery with neurologic sequelae as hydrocephalus was observed. Microbiological diagnosis was obtained by serological tests and reverse transcriptase-polymerase chain reaction. Sequencing of polymerase chain reaction products from the S and M segments was carried out. TOSv may be a causative agent in severe meningoencephalitis.
Baldelli
Franco
F
Clinica di Malattie Infettive, Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Universita degli Studi di Perugia, Perugia, Italy. rprof2f1@unipg.it
Ciufolini
Maria Grazia
MG
Francisci
Daniela
D
Marchi
Antonella
A
Venturi
Giulietta
G
Fiorentini
Cristiano
C
Luchetta
Maria Laura
ML
Bruto
Lidia
L
Pauluzzi
Sergio
S
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000503:physiopathology* / Q000821:virology; D010217:Phlebotomus Fever / Q000503:physiopathology* / Q000821:virology; D012367:RNA, Viral / Q000032:analysis; D029301:Sandfly fever Naples virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D012698:Serologic Tests
D012367:RNA, Viral