title: Hepatic lipogenesis gene expression in two experimental egg-laying lines divergently selected on residual food consumption.
abstract: Two Rhode Island Red egg-laying lines have been divergently selected on residual food intake (low intake R- line, high intake R+ line) for 19 generations. In addition to direct response, correlated responses have altered several other traits such as carcass adiposity and lipid contents of several tissues, the R+ animals being leaner than the R- ones. In a search for the biological origin of the differences observed in fat deposit, the hepatic mRNA amounts of genes involved in lipid metabolism were investigated. No difference was found between lines for mRNA levels of ATP citrate-lyase, acetyl-CoA carboxylase, fatty acid synthase, malic enzyme and CCAAT/enhancer binding protein alpha, a transcription factor acting on several lipogenesis genes. The genes coding for stearoyl-CoA desaturase and apolipoprotein A1 displayed significantly lower mRNA levels in the R+ cockerels compared to the R-. All together these mRNA levels explained 40% of the overall variability of abdominal adipose tissue weight, suggesting an important role of both genes in the fatness variability.
authors.affiliation: Laboratoire de génétique animale, Institut national de la recherche agronomique, Ecole nationale supérieure agronomique de Rennes, 65 rue de Saint-Brieuc, 35042 Rennes Cedex, France.
authors.forename: S
authors.initials: S
authors.lastname: Lagarrigue
authors.forename: S
authors.initials: S
authors.lastname: Daval
authors.forename: A
authors.initials: A
authors.lastname: Bordas
authors.forename: M
authors.initials: M
authors.lastname: Douaire