title: A myeloablative allograft after rejection of two consecutive nonmyeloablative transplants from two different HLA identical siblings.
abstract: A 55-year-old female with standard risk AML in second CR received an allogenic transplant from an HLA-matched sibling, using a nonmyeloablative conditioning regimen (NMST). On day +139, she rejected her graft with autologous reconstitution. She received a second NMST from a different HLA-matched sibling with an identical conditioning regimen and immunosuppression. On day +110, she rejected the second graft, with autologous reconstitution with blasts. She received a third allograft from the first sibling with a myeloablative busulfan-based conditioning regimen. She is now day +270, in CR, with full donor chimerism.
authors.affiliation: UO Ematologia, Università degli Studi di Pisa e Azienda Ospedaliera Pisana, Pisa, Italy. f.papineschi@do.med.unipi.it
authors.forename: F
authors.initials: F
authors.lastname: Papineschi
authors.forename: E
authors.initials: E
authors.lastname: Benedetti
authors.forename: S
authors.initials: S
authors.lastname: Galimberti
authors.forename: F
authors.initials: F
authors.lastname: Caracciolo
authors.forename: R
authors.initials: R
authors.lastname: Fazzi
authors.forename: M
authors.initials: M
authors.lastname: Petrini
mesh_terms: D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008875:Middle Aged; D033581:Stem Cell Transplantation; D018183:Transplantation Chimera; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous / Q000276:immunology*; D016896:Treatment Outcome