[Effect of himantane on the rat embryo development].
Himantane introduced via a gastric tube to pregnant rats in a dose of 10, 30, 50, and 100 mg/kg produced a dose-dependent embryotoxic and teratogenic action. An analysis of the experimental results and published data suggests that the embryotoxicity of himantane can be related to its general toxic action upon the organism of pregnant female rats.
Durnev
A D
AD
Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Smol'nikova
N M
NM
Nemova
E P
EP
Val'dman
E A
EA
Avdiunina
N I
NI
Piatin
B M
BM
Seredenin
S B
SB
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000218:Adamantane / Q000031:analogs & derivatives* / Q000633:toxicity*; D000818:Animals; D000978:Antiparkinson Agents / Q000633:toxicity*; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D007928:Lethal Dose 50; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D051381:Rats
D000978:Antiparkinson Agents; C122112:N-(2-adamantyl)hexamethylenimine; D000218:Adamantane