Association of cytogenetic abnormalities with detection of BCR-ABL fusion transcripts in children with T-lineage lymphoproliferative diseases (T-ALL and T-NHL).
Detection of Philadelphia chromosome (Ph) in childhood T-lineage acute lymphoproliferative disorders is a rare event. Additional cytogenetic abnormalities are particularly uncommon in ALL. We here report two cases with T lineage acute lymphoproliferative disorders (T-ALL and T-NHL) presenting with both cytogenetic alterations and BCR-ABL fusion transcripts, associated with an aggressive presentation and a poor outcome. We point out firstly on the cytogenetic aberrations, supporting the hypothesis of multi-lineage involvement of ALL expressing Ph chromosome; secondly, on the persistence of T-cell leukemic clone detected by minimal residual disease (MRD) analysis, despite of the early disappearance of BCR-ABL fusion transcript.
Lo Nigro
Luca
L
Center of Pediatric Hematology and Oncology, University of Catania, Italy. lucaln@yahoo.com
Sainati
Laura
L
Mirabile
Elena
E
Lanciotti
Marina
M
Poli
Amelia
A
Leszl
Anna
A
Basso
Giuseppe
G
D000293:Adolescent; D019070:Cell Lineage; D002648:Child; D002869:Chromosome Aberrations; D002999:Clone Cells / Q000473:pathology; D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D018365:Neoplasm, Residual / Q000473:pathology; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D012334:RNA, Neoplasm / Q000032:analysis
D012334:RNA, Neoplasm; D016044:Fusion Proteins, bcr-abl