[Nephroprotective effect of bilobil in experimental acute kidney failure].
Bilobil, a commercial preparation based on Ginkgo biloba extract, improves the functional state of kidney and increases the survival of rats with glycerol-induced acute renal insufficiency. One possible mechanism of this effect is related to the ability of bilobil to simulate the renal antioxidant system, thus decreasing the rate of lipid peroxidation processes and reducing the renal damage. The results show good prospects for the use of bilobil in nephrology.
Nazarenko
M E
ME
Departments of Pharmacology and General, Organic, and Bioorganic Chemistry, Ivanovo State Medical Academy, Ivanovo, 153462 Russia.
Shtrygol'
S Iu
SIu
Slobodin
V B
VB
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D005260:Female; D020441:Ginkgo biloba / Q000737:chemistry*; D005990:Glycerol; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
D000975:Antioxidants; D010936:Plant Extracts; D005990:Glycerol