title: Individual analysis of EEG frequency and band power in mild Alzheimer's disease.
abstract: OBJECTIVE
  This EEG study investigates the role of the cholinergic system, cortico-cortical connections, and sub-cortical white matter on the relationship between individual EEG frequencies and their relative power bands.
  
  
  METHODS
  EEGs were recorded at rest in 30 normal elderly subjects (Nold), 60 mild Alzheimer disease (AD) and 20 vascular dementia (VaD) patients, comparable for Mini Mental State Evaluation scores (MMSE 17-24). Individual EEG frequencies were indexed by the theta/alpha transition frequency (TF) and by the individual alpha frequency (IAF) with power peak in the extended alpha range (5-14 Hz). Relative power was separately computed for delta, theta, alpha1, alpha2, and alpha3 bands, on the basis of the TF and IAF.
  
  
  RESULTS
  Using normal subjects as a reference, VaD patients showed 'slowing' of alpha frequency (TF-IAF) and lower alpha2 power; Mild AD patients showed lower alpha2 and alpha3 power; delta power was higher in both AD and VaD patients; Theta power was higher only in VaD patients.
  
  
  CONCLUSIONS
  Individual analysis of the alpha frequency and power can discriminate mild AD from VaD and normal elderly subjects.
  
  
  CONCLUSIONS
  This analysis may probe pathophysiological mechanisms causing AD and VaD.
authors.affiliation: Dipartimento Fisiologia Umana e Farmacologia, Università degli Studi di Roma La Sapienza, P.le Aldo Moro 5, 00185 Rome, Italy.
authors.forename: Davide V
authors.initials: DV
authors.lastname: Moretti
authors.forename: Claudio
authors.initials: C
authors.lastname: Babiloni
authors.forename: Giuliano
authors.initials: G
authors.lastname: Binetti
authors.forename: Emanuele
authors.initials: E
authors.lastname: Cassetta
authors.forename: Gloria
authors.initials: G
authors.lastname: Dal Forno
authors.forename: Florinda
authors.initials: F
authors.lastname: Ferreric
authors.forename: Raffaele
authors.initials: R
authors.lastname: Ferri
authors.forename: Bartolo
authors.initials: B
authors.lastname: Lanuzza
authors.forename: Carlo
authors.initials: C
authors.lastname: Miniussi
authors.forename: Flavio
authors.initials: F
authors.lastname: Nobili
authors.forename: Guido
authors.initials: G
authors.lastname: Rodriguez
authors.forename: Serenella
authors.initials: S
authors.lastname: Salinari
authors.forename: Paolo M
authors.initials: PM
authors.lastname: Rossini
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology; D015140:Dementia, Vascular / Q000503:physiopathology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D012815:Signal Processing, Computer-Assisted