title: Histologic comparison of vibrating guidewire with conventional guidewire technique in an experimental coronary in vivo model.
abstract: OBJECTIVE
  To compare the damage caused by vibrating guidewire manipulation and conventional guidewire manipulation of soft coronary wires in normal sheep coronary arteries.
  
  
  METHODS
  Using an intact sheep model the two methods of passing a coronary guidewire down a normal coronary artery under fluoroscopic screening control were studied. The resulting arterial damage caused by the two techniques was studied histologically. The severity of damage was scored from 1 (no damage) to 4 (severe damage) and expressed as: (a) percentage of damaged sections, (b) mean damage score per section and (c) percentage of sections suffering the most severe degree of damage (scores 3 and 4).
  
  
  RESULTS
  One hundred and sixty-eight sections were studied. The percentage of damaged sections was lower in the vibrating guidewire group (p = 0.004). The mean damage score and the percentage of sections with a damage score of 3 or 4 were smaller in the vibrating guidewire group than in the conventional guidewire manipulation group (p = 0.001 and p = 0.009, respectively).
  
  
  CONCLUSIONS
  Both methods of guidewire manipulation cause identifiable vascular damage. The extent and severity of damage appear greater when the guidewire is manipulated manually.
authors.affiliation: Department of Cardiology, School of Medicine, University of Ioannina, GR 451 10 Ioannina, Greece.
authors.forename: Christos S
authors.initials: CS
authors.lastname: Katsouras
authors.forename: Lampros K
authors.initials: LK
authors.lastname: Michalis
authors.forename: Vassiliki D
authors.initials: VD
authors.lastname: Malamou-Mitsi
authors.forename: Demetra
authors.initials: D
authors.lastname: Niokou
authors.forename: Vassilios
authors.initials: V
authors.lastname: Giogiakas
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Nikas
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Massouras
authors.forename: Pavlos
authors.initials: P
authors.lastname: Dallas
authors.forename: Dimitrios K
authors.initials: DK
authors.lastname: Tsetis
authors.forename: Dimitris A
authors.initials: DA
authors.lastname: Sideris
authors.forename: Michael R
authors.initials: MR
authors.lastname: Rees
mesh_terms: D000800:Angioplasty, Balloon / Q000009:adverse effects* / Q000295:instrumentation* / Q000379:methods; D000818:Animals; D003331:Coronary Vessels / Q000293:injuries* / Q000473:pathology*; D004867:Equipment Design / Q000009:adverse effects; D008297:Male; D023421:Models, Animal; D012756:Sheep; D014732:Vibration