A myeloablative allograft after rejection of two consecutive nonmyeloablative transplants from two different HLA identical siblings.
A 55-year-old female with standard risk AML in second CR received an allogenic transplant from an HLA-matched sibling, using a nonmyeloablative conditioning regimen (NMST). On day +139, she rejected her graft with autologous reconstitution. She received a second NMST from a different HLA-matched sibling with an identical conditioning regimen and immunosuppression. On day +110, she rejected the second graft, with autologous reconstitution with blasts. She received a third allograft from the first sibling with a myeloablative busulfan-based conditioning regimen. She is now day +270, in CR, with full donor chimerism.
Papineschi
F
F
UO Ematologia, Università degli Studi di Pisa e Azienda Ospedaliera Pisana, Pisa, Italy. f.papineschi@do.med.unipi.it
Benedetti
E
E
Galimberti
S
S
Caracciolo
F
F
Fazzi
R
R
Petrini
M
M
D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006650:Histocompatibility Testing; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008875:Middle Aged; D033581:Stem Cell Transplantation; D018183:Transplantation Chimera; D019172:Transplantation Conditioning / Q000379:methods; D014184:Transplantation, Homologous / Q000276:immunology*; D016896:Treatment Outcome