A new phloroglucinol derivative from the brown alga Eisenia bicyclis: potential for the effective treatment of diabetic complications.
A new phloroglucinol derivative (1) and two known compounds (2 and 3) were isolated from the brown alga Eisenia bicyclis. These isolates exhibit inhibitory activity on glycation and alpha-amylase. Their structures were determined on the basis of spectroscopic data.
Okada
Yoshihito
Y
Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose-shi, Tokyo 204-8588, Japan.
Ishimaru
Akiko
A
Suzuki
Ryuichiro
R
Okuyama
Toru
T
D003920:Diabetes Mellitus / Q000188:drug therapy*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D017127:Glycation End Products, Advanced / Q000037:antagonists & inhibitors; D007564:Japan; D015394:Molecular Structure; D000459:Phaeophyceae / Q000737:chemistry*; D010696:Phloroglucinol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000516:alpha-Amylases / Q000037:antagonists & inhibitors
D004791:Enzyme Inhibitors; D017127:Glycation End Products, Advanced; D010696:Phloroglucinol; D000516:alpha-Amylases