title: Methanol extract of the oyster mushroom, Pleurotus florida, inhibits inflammation and platelet aggregation.
abstract: The antiinflammatory and platelet aggregation inhibiting activities of the methanol extract of Pleurotus florida Eger, an edible and commercially grown mushroom, were investigated. The extract showed significant activity in ameliorating acute inflammation induced by carrageenan and chronic inflammation by formalin at 500 and 1000 mg/kg body weight. The effect was comparable to the standard reference drug, diclofenac. The extract also showed significant platelet aggregation inhibiting activity of washed human platelets. Adenosine 5'-diphosphate (ADP) induced platelet aggregation was inhibited by 88% to 95% at a concentration of 500 microg/mL of the extract after a preincubation time of 5, 10 and 20 min. The marked antiinflammatory and platelet aggregation inhibiting properties of this mushroom suggest its potential therapeutic use against vascular disorders.
authors.affiliation: Amala Cancer Research Centre, Amala Nagar, Thrissur 680 553, India.
authors.forename: Nayana
authors.initials: N
authors.lastname: Jose
authors.forename: T A
authors.initials: TA
authors.lastname: Ajith
authors.forename: K K
authors.initials: KK
authors.lastname: Janardhanan
mesh_terms: D000244:Adenosine Diphosphate; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005557:Formaldehyde; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D020076:Pleurotus
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D005557:Formaldehyde; D000244:Adenosine Diphosphate; D002351:Carrageenan