[Dynamic change in interleukin-18 and its relationships with multiple organ dysfunction syndrome].
OBJECTIVE
To determine interleukin-18 (IL-18) in plasma after trauma, and evaluate its relationship with multiple organ dysfunction syndromes.


METHODS
A total of 54 patients were enrolled and divided into low injury seriousness score (L-ISS) and high injury seriousness score (H-ISS) groups. Blood IL-18 levels were determined on admission, day 4, day 7 and day 14 after trauma using enzyme-linked immunoadsorbent assay (ELISA), and the relationship between its level and organ dysfunction was analyzed.


RESULTS
Plasma IL-18 concentration was significantly increased on posttrauma day 4 and day 7. Also, plasma IL-18 concentration was significantly higher in patients with organ dysfunction.


CONCLUSIONS
This study suggests that major trauma can lead to a marked elevation of IL-18, which might be associated with organ dysfunction.
Liu
Jing-Qu
JQ
Trauma Center, 304th Hospital of PLA, Beijing 100037, China.
He
Zhong-Jie
ZJ
Lin
Hong-Yuan
HY
Yao
Yong-Ming
YM
Sheng
Zhi-Yong
ZY
D000328:Adult; D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D009102:Multiple Organ Failure / Q000097:blood*; D012044:Regression Analysis; D014947:Wounds and Injuries / Q000097:blood* / Q000378:metabolism
D015415:Biomarkers; D020382:Interleukin-18