title: Decitabine: development of a DNA methyltransferase inhibitor for hematological malignancies.
abstract: Decitabine (DAC) is a small molecule nucleotide analog that is incorporated into DNA and traps human DNA methyltransferases. Although initially developed as a cytotoxic agent, low-dose DAC is enjoying a revival as a specific inhibitor of hypermethylation in cancer. DAC has activity in several hematological diseases, especially myelodysplastic syndrome, chronic myelogenous leukemia and acute myeloid leukemia. Clinical and preclinical advances are presented in this review.
authors.affiliation: jlyons1@ireland.com
authors.forename: John
authors.initials: J
authors.lastname: Lyons
authors.forename: Emel
authors.initials: E
authors.lastname: Bayar
authors.forename: Gil
authors.initials: G
authors.lastname: Fine
authors.forename: Michael
authors.initials: M
authors.lastname: McCullar
authors.forename: Randee
authors.initials: R
authors.lastname: Rolens
authors.forename: Joseph
authors.initials: J
authors.lastname: Rubinfeld
authors.forename: Craig
authors.initials: C
authors.lastname: Rosenfeld
mesh_terms: D000818:Animals; D001374:Azacitidine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D015254:DNA Modification Methylases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000077209:Decitabine; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D019337:Hematologic Neoplasms / Q000188:drug therapy* / Q000201:enzymology; D006801:Humans
chemical_list: D004791:Enzyme Inhibitors; D000077209:Decitabine; D015254:DNA Modification Methylases; D001374:Azacitidine