title: The multiple sclerosis impact scale (MSIS-29) is a reliable and sensitive measure.
abstract: OBJECTIVE
  The aim of this study was to assess the psychometric properties of the Multiple Sclerosis Impact Scale (MSIS-29) for patients in the community and in a hospital setting.
  
  
  METHODS
  During an epidemiological study, 172 people with multiple sclerosis (MS) were examined and completed the MSIS-29, the London Handicap Scale, and Beck's Depression Inventory; disability was assessed by the Kurtzke Expanded Disability Status Score (EDSS) and the Multiple Sclerosis Functional Composite. At the hospital neurology clinic, 102 MS patients completed the MSIS-29 and EDSS assessments were performed; 41 of these patients had repeat evaluations six months later. The psychometric properties of the MSIS-29 were examined.
  
  
  RESULTS
  In the 172 community and the 102 hospital patients the psychometric properties of the MSIS-29 were satisfactory, with high convergent and low divergent validity. It was significantly responsive to change in the contexts of self-reported change (p<0.034) and EDSS worsening (p<0.001). The MSIS-29 physical score did not change over time when the EDSS was stable, and increased significantly in proportion to EDSS deterioration (p = 0.014).
  
  
  CONCLUSIONS
  The psychometric properties of the MSIS-29 are acceptable; it is a valuable outcome measure in intervention studies of patients with MS.
authors.affiliation: Department of Neurology, University College Dublin and St Vincent's University Hospital, Dublin, Ireland. cmcguigan@doctors.org.uk
authors.forename: C
authors.initials: C
authors.lastname: McGuigan
authors.forename: M
authors.initials: M
authors.lastname: Hutchinson
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000209:etiology; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D011446:Prospective Studies; D011594:Psychometrics / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires