A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum.
A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.
Torres
Avital
A
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Hebrew University of Jerusalem, Israel.
Hochberg
Malka
M
Pergament
Inna
I
Smoum
Reem
R
Niddam
Valerie
V
Dembitsky
Valery M
VM
Temina
Marina
M
Dor
Inka
I
Lev
Ovadia
O
Srebnik
Morris
M
Enk
Claes D
CD
D001203:Ascomycota / Q000737:chemistry* / Q000235:genetics; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004890:Erythema / Q000209:etiology / Q000517:prevention & control; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D008011:Lichens / Q000737:chemistry / Q000235:genetics; D011740:Pyrimidine Dimers / Q000737:chemistry / Q000528:radiation effects; D011759:Pyrrolidines / Q000737:chemistry* / Q000494:pharmacology; D011837:Radiation-Protective Agents / Q000737:chemistry* / Q000494:pharmacology*; D012867:Skin / Q000528:radiation effects; D013056:Spectrophotometry, Ultraviolet; D014466:Ultraviolet Rays / Q000009:adverse effects*
D005960:Glucosides; D011740:Pyrimidine Dimers; D011759:Pyrrolidines; D011837:Radiation-Protective Agents; C483008:collemin A