title: Posterior urethral valves: incidence and progress of vesicoureteric reflux after primary fulguration.
abstract: This is a prospective study of 20 cases of posterior urethral valves (PUV) presenting between the ages of 12 days and 5.5 years (median 15 months) in order to determine the incidence and progress of vesicoureteric reflux (VUR), hydronephrosis (HN), and renal functional status. The efficacy of fulguration as the sole modality of treatment for PUV was assessed in terms of improvement or disappearance of VUR over a 6-month follow-up period. VUR was present in 60% of the patients, being unilateral in 41.7%. Out of 19 renal units with VUR, reflux subsided in 31.5% by 3 months and 78.94% by 6 months. The blood urea and serum creatinine levels, which were raised in 50% of the patients at presentation, came down to normal by 6 months in all the cases. Improvement in glomerular filtration rates (GFR) was noted in all the children at each follow-up and was found to be statistically significant ( p<0.01). HN was present in all the patients at presentation and was bilateral in 90%. It decreased significantly during the follow-up period, though its complete disappearance was seen only in one case. Vesicoureteric reflux dysplasia syndrome (VURD) was present in two cases. Our study showed that VUR disappeared in a majority of the cases by 6 months once adequate urethral patency was restored, although hydronephrosis persisted.
authors.affiliation: Department of Pediatric Surgery, Post Graduate Institute of Medical Education and Research, 160 012, Chandigarh, India.
authors.forename: K
authors.initials: K
authors.lastname: Priti
authors.forename: K L N
authors.initials: KL
authors.lastname: Rao
authors.forename: P
authors.initials: P
authors.lastname: Menon
authors.forename: N
authors.initials: N
authors.lastname: Singh
authors.forename: B R
authors.initials: BR
authors.lastname: Mittal
authors.forename: A
authors.initials: A
authors.lastname: Bhattacharya
authors.forename: S K
authors.initials: SK
authors.lastname: Mitra
mesh_terms: D002675:Child, Preschool; D018450:Disease Progression; D004564:Electrocoagulation / Q000379:methods*; D006801:Humans; D006869:Hydronephrosis / Q000209:etiology / Q000503:physiopathology; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000503:physiopathology; D011446:Prospective Studies; D014522:Urethral Diseases / Q000150:complications* / Q000453:epidemiology / Q000601:surgery*; D014718:Vesico-Ureteral Reflux / Q000209:etiology / Q000503:physiopathology*