title: Chronic granulomatous lung infection caused by the dimorphic fungus Emmonsia sp.
abstract: A 64-year old farmer developed cough, dyspnoea on exertion, and recurrent febrile episodes. X-ray and CT scan revealed bilateral lower lobe opacities in his lungs. A transbronchial biopsy was performed and histopathological findings were interpreted as consistent with a pulmonary necrotizing clear-cell carcinoma and later as a Pneumocystis carinii pneumonia. Due to persistence of symptoms, six months later another lung biopsy was performed and a mould was cultured which was identified by 18S rDNA sequencing as Emmonsia sp. The patient showed some improvement under itraconazole treatment. This is the first description of a human infection with Emmonsia sp. in Germany.
authors.affiliation: Department of Medical Microbiology and Hygiene, University of Ulm, Ulm, Germany. nele.wellinghausen@medizin.uni-ulm.de
authors.forename: Nele
authors.initials: N
authors.lastname: Wellinghausen
authors.forename: Winfried V
authors.initials: WV
authors.lastname: Kern
authors.forename: Gerhard
authors.initials: G
authors.lastname: Haase
authors.forename: Eva
authors.initials: E
authors.lastname: Rozdzinski
authors.forename: Peter
authors.initials: P
authors.lastname: Kern
authors.forename: Reinhard
authors.initials: R
authors.lastname: Marre
authors.forename: Andreas
authors.initials: A
authors.lastname: Essig
authors.forename: Jürgen
authors.initials: J
authors.lastname: Hetzel
authors.forename: Martin
authors.initials: M
authors.lastname: Hetzel
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D002912:Chrysosporium / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D004275:DNA, Ribosomal / Q000032:analysis; D006105:Granulomatous Disease, Chronic / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008172:Lung Diseases, Fungal / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009181:Mycoses / Q000188:drug therapy / Q000382:microbiology*; D012337:RNA, Ribosomal, 18S / Q000235:genetics; D017422:Sequence Analysis, DNA
chemical_list: D000935:Antifungal Agents; D004275:DNA, Ribosomal; D012337:RNA, Ribosomal, 18S; D017964:Itraconazole