title: Polycomb group proteins in cell cycle progression and cancer.
abstract: Epigenetic deregulation of gene expression is emerging as key mechanism in tumorigenesis. Deregulated activity of the chromatin remodeling Polycomb Repressive Complex 2 (PRC2) has recently been shown to be a frequent event in human tumors. Here we discuss these findings and speculate on the role of the PRC2 complex in controlling gene expression during normal cellular proliferation and cancer development.
authors.affiliation: Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.
authors.forename: Diego
authors.initials: D
authors.lastname: Pasini
authors.forename: Adrian P
authors.initials: AP
authors.lastname: Bracken
authors.forename: Kristian
authors.initials: K
authors.lastname: Helin
mesh_terms: D000818:Animals; D015153:Blotting, Western; D002453:Cell Cycle; D002455:Cell Division; D002843:Chromatin / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins; D004330:Drosophila; D005786:Gene Expression Regulation; D020868:Gene Silencing; D006367:HeLa Cells; D006801:Humans; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000378:metabolism*; D063151:Polycomb Repressive Complex 2; D063146:Polycomb-Group Proteins; D011233:Precipitin Tests; D011506:Proteins / Q000378:metabolism; D034741:RNA, Small Interfering / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors
chemical_list: D002843:Chromatin; D004268:DNA-Binding Proteins; D063146:Polycomb-Group Proteins; D011506:Proteins; D034741:RNA, Small Interfering; D012097:Repressor Proteins; D014157:Transcription Factors; D004247:DNA; C103523:EZH1 protein, human; D063151:Polycomb Repressive Complex 2