title: Plasma ghrelin concentratin in the short-term following biliopancreatic diversion.
abstract: BACKGROUND
  Ghrelin is a hormone that increases food intake in rodents and in humans. After gastric bypass surgery, a marked decrease in circulating ghrelin levels has been observed, and it was suggested that this may contribute to the weight-reducing effect of gastric bypass. In this study, the changes in circulating ghrelin levels following biliopancreatic diversion (BPD) were investigated.
  
  
  METHODS
  Serum ghrelin concentration was measured in obese patients prior to and 5 days and 2 months following BPD.
  
  
  RESULTS
  At the short-term following BPD, marked reduction of serum ghrelin was observed, while thereafter the values returned to initial levels.
  
  
  CONCLUSIONS
  Unlike following reducing diet or gastric bypass, following BPD only an initial reduction of serum ghrelin concentration was observed, while at 2 months following the operation, when food intake had nearly completely resumed, the values returned to the preoperative levels. This is consistent with the hypothesis that ghrelin production from the stomach is greatly influenced by the direct contact of ingested food with the gastric cells.
authors.affiliation: Dipartimento di Discipline Chirurgiche e Metodologie Integrate, Università di Genova, Genova, Italy. adami@unige.it
authors.forename: Gian Franco
authors.initials: GF
authors.lastname: Adami
authors.forename: Renzo
authors.initials: R
authors.lastname: Cordera
authors.forename: Guiseppe
authors.initials: G
authors.lastname: Marinari
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lamerini
authors.forename: Gabriella
authors.initials: G
authors.lastname: Andraghetti
authors.forename: Nicola
authors.initials: N
authors.lastname: Scopinaro
mesh_terms: D000713:Anastomosis, Roux-en-Y; D001066:Appetite / Q000502:physiology; D015904:Biliopancreatic Diversion; D004435:Eating / Q000502:physiology; D005260:Female; D005743:Gastrectomy; D054439:Ghrelin; D013006:Growth Hormone / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D008297:Male; D009767:Obesity, Morbid / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery*; D036361:Peptide Hormones / Q000096:biosynthesis* / Q000097:blood
chemical_list: D054439:Ghrelin; D036361:Peptide Hormones; D013006:Growth Hormone