How to use statins in patients with chronic liver disease.
Clinicians may be concerned about prescribing statins to patients with chronic liver disease, but there is little evidence to suggest that drug-induced liver injury from statins is increased in these patients. Thus, we should prescribe statins for the same indications in patients with chronic liver disease as in patients without, but with closer monitoring. However, patients with acute liver disease (acute viral hepatitis, alcoholic hepatitis) should not take statins until they have recovered.
Russo
Mark W
MW
Center for the Study of Hepatitis C, Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, NY, USA. Mark_Russo@med.unc.edu
Jacobson
Ira M
IM
D000410:Alanine Transaminase / Q000097:blood; D000465:Algorithms; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D001219:Aspartate Aminotransferases / Q000097:blood; D002908:Chronic Disease; D015897:Comorbidity; D000075202:Contraindications; D003324:Coronary Artery Disease / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology; D016903:Drug Monitoring; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008107:Liver Diseases / Q000201:enzymology* / Q000453:epidemiology
D000924:Anticholesteremic Agents; D006903:Hydroxymethylglutaryl CoA Reductases; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase