Synthesis of 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo-[b,f]furo[2,3-d]oxepin derivatives as potential anxiolytic agents.
New synthesis approaches that have led to a series of novel tetrahydrodibenzo[b,f]furo[2,3-d]oxepin derivatives are described. According to preliminary data these novel tetracycles can be useful intermediates for the preparation of potential new therapeutic agents.
Trabanco
Andrés Avelino
AA
Johnson & Johnson Pharmaceutical Research & Development, a Division of Janssen-Cilag SA, Toledo, Spain. atrabanc@prdes.jnj.com
Alonso
José Manuel
JM
Andrés
José Ignacio
JI
Cid
José Maria
JM
Fernández
Javier
J
Iturrino
Laura
L
Megens
Anton
A
D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010082:Oxepins / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D014151:Anti-Anxiety Agents; D007202:Indicators and Reagents; D010082:Oxepins