A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective.
Predatory bacteria remain molecularly enigmatic, despite their presence in many microbial communities. Here we report the complete genome of Bdellovibrio bacteriovorus HD100, a predatory Gram-negative bacterium that invades and consumes other Gram-negative bacteria. Its surprisingly large genome shows no evidence of recent gene transfer from its prey. A plethora of paralogous gene families coding for enzymes, such as hydrolases and transporters, are used throughout the life cycle of B. bacteriovorus for prey entry, prey killing, and the uptake of complex molecules.
Rendulic
Snjezana
S
Max-Planck-Institute for Developmental Biology, 72076 Tübingen, Germany.
Jagtap
Pratik
P
Rosinus
Andrea
A
Eppinger
Mark
M
Baar
Claudia
C
Lanz
Christa
C
Keller
Heike
H
Lambert
Carey
C
Evans
Katy J
KJ
Goesmann
Alexander
A
Meyer
Folker
F
Sockett
R Elizabeth
RE
Schuster
Stephan C
SC
D000255:Adenosine Triphosphate / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D001422:Bacterial Adhesion / Q000235:genetics; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D001501:Bdellovibrio / Q000166:cytology / Q000235:genetics* / Q000254:growth & development* / Q000502:physiology; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D019295:Computational Biology; D003600:Cytosol / Q000378:metabolism; D010861:Fimbriae, Bacterial / Q000235:genetics / Q000502:physiology; D005407:Flagella / Q000235:genetics / Q000502:physiology; D022761:Gene Transfer, Horizontal; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D023281:Genomics; D006090:Gram-Negative Bacteria; D006867:Hydrolases / Q000235:genetics / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D016366:Open Reading Frames; D010457:Peptidoglycan / Q000378:metabolism; D017422:Sequence Analysis, DNA
D000596:Amino Acids; D001426:Bacterial Proteins; D026901:Membrane Transport Proteins; D010457:Peptidoglycan; D000255:Adenosine Triphosphate; D006867:Hydrolases