title: Maternal adrenalectomy affects development of adrenal medulla.
abstract: This work investigates the effects of maternal adrenalectomy (ADX) on the development of the adrenal medulla. Adrenal catecholamines (AC) were measured at postnatal day (PN) 1, 8, 12 and 22 in rat offspring of ADX dams and in pups of control dams. The pups of ADX rats showed a reduction in AC concentrations in the adrenal medulla at PN 1, 12 and 22, although these were higher than in the pups of sham dams at PN 8. Further, in the pups of control mothers, there was an increase in ACs during the first two weeks of life whereas pups of ADX mothers only showed increases in noradrenaline, dopamine and adrenaline levels at day 8. These results suggest that maternal absence of corticosterone affects the medulla catecholamine content during development. These data support the idea that a maternal glucocorticoids are involved in the differentiation or/and maturation of the adrenal medulla.
authors.affiliation: Department of Animal Biology-II (Animal Physiology), Faculty of Biological Sciences, Complutense University of Madrid, Madrid, Spain.
authors.forename: M L
authors.initials: ML
authors.lastname: Leret
authors.forename: V
authors.initials: V
authors.lastname: Peinado
authors.forename: J C
authors.initials: JC
authors.lastname: González
authors.forename: L M
authors.initials: LM
authors.lastname: Suárez
authors.forename: C
authors.initials: C
authors.lastname: Rúa
mesh_terms: D000313:Adrenal Medulla / Q000254:growth & development* / Q000378:metabolism*; D000315:Adrenalectomy; D000704:Analysis of Variance; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004298:Dopamine / Q000378:metabolism; D005260:Female; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004298:Dopamine; D009638:Norepinephrine