title: Inactivation of transmissible spongiform encephalopathy (prion) agents by environ LpH.
abstract: Agents causing transmissible spongiform encephalopathy (TSE) diseases are resistant to inactivation by several conventional decontamination methods. Using an animal bioassay, we compared the TSE agent disinfectant efficacy of a commercially available product referred to alternatively as LpH-SE, LpH-AG, or LpH-st to that of a similarly named but differently formulated product, Environ LpH, which was found to be an effective TSE agent disinfectant in a previous study. Here, we found LpH-SE to be at least 10(4)-fold to 10(5)-fold less effective than Environ LpH.
authors.affiliation: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA. rrace@niaid.nih.gov
authors.forename: Richard E
authors.initials: RE
authors.lastname: Race
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Raymond
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006224:Cricetinae; D006018:Glycols / Q000737:chemistry / Q000494:pharmacology*; D008647:Mesocricetus; D017096:Prion Diseases / Q000378:metabolism* / Q000517:prevention & control; D011328:Prions / Q000187:drug effects* / Q000472:pathogenicity; D020005:Propanols / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C482265:Environ LpH; D006018:Glycols; D011328:Prions; D020005:Propanols