Regulation of glyceroneogenesis and phosphoenolpyruvate carboxykinase by fatty acids, retinoic acids and thiazolidinediones: potential relevance to type 2 diabetes.
Recent studies brought adipocyte glyceroneogenesis back to the fore as an important pathway in fatty acid homeostasis and underlined the key role played by cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) in this pathway. The present review analyses the mechanisms by which a series of hormones and nutrients affect PEPCK-C gene transcription and glyceroneogenesis and describes evidence for disregulation of this pathway in type 2 diabetes.
Tordjman
Joan
J
UMR-S 530 Inserm-Université René Descartes, centre Universitaire-U.F.R. Biomédicale, 45, rue des Saints-Pères, 75006 Paris, France.
Khazen
Wael
W
Antoine
Bénédicte
B
Chauvet
Geneviève
G
Quette
Joelle
J
Fouque
Françoise
F
Beale
Elmus G
EG
Benelli
Chantal
C
Forest
Claude
C
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000378:metabolism / Q000503:physiopathology; D005227:Fatty Acids / Q000494:pharmacology*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D005990:Glycerol / Q000378:metabolism*; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000235:genetics* / Q000378:metabolism*; D045162:Thiazolidinediones / Q000494:pharmacology*; D014212:Tretinoin / Q000494:pharmacology*
D005227:Fatty Acids; D045162:Thiazolidinediones; D014212:Tretinoin; C089946:2,4-thiazolidinedione; D010729:Phosphoenolpyruvate Carboxykinase (GTP); D005990:Glycerol