[Effect of prolactin on the level of corticosterone in the blood and synthesis of lymphocyte-activating factors by macrophages under conditions of glucocorticoid loading].
The present study examines in vivo the interaction between glucocorticoids and prolactin, and immunomodulating activity of prolactin, including prolactin-induced changes in production of lymphocyte-activating factors and alteration in humoral immune response. It was shown that prolactin application increased the level of corticosterone in the rat blood. Administration of prolactin prior to hydrocortisone administration induced alteration in the level of corticosterone that depended on the dose of hydrocortisone. Application of hydrocortisone reduced humoral immune response and lymphocyte-activating factors production by peritoneal macrophages. Administration of prolactin prior to hydrocortisone administration prevents inhibitory action of glucocorticoids/on humoral immune response and lymphocyte-activating factors production by macrophages.
Fomicheva
E E
EE
Institute of Experimental Medicine, Russian Acad. Med. Sci., 197376, St. Petersburg, Acad. Pavlov St., 12, Russia.
Nemirovich-Danchenko
E A
EA
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D003345:Corticosterone / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D006854:Hydrocortisone / Q000008:administration & dosage* / Q000172:deficiency*; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000097:blood; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011388:Prolactin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D007375:Interleukin-1; D011388:Prolactin; D003345:Corticosterone; D006854:Hydrocortisone