Solid-phase strategies for the design and synthesis of heterocyclic molecules of medicinal interest.
Recently, there has been a wealth of reports concerning the polymer-supported traceless synthesis of heterocyclic structures of medicinal interest. In 2002, important advances included the continued use of cyclative cleavage strategies to obtain novel heterocyclic structures with high chemical diversity. In addition to these strategies, several reports based on a novel approach involving the use of common combinatorial scaffolds for the generation of a variety of heterocyclic structures have also appeared. This review covers the application of these two approaches to a wide array of compounds based on azoles quinazolines, indoles, pyridines, isoxazolines, piperazines and pyrroles.
Kundu
Bijoy
B
Central Drug Research Institute, Medicinal Chemistry Division, Lucknow-226 001, India. bijoy_kundu@yahoo.com
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015195:Drug Design; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D007194:India; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*
D006571:Heterocyclic Compounds; D004364:Pharmaceutical Preparations