title: Lactose-appended schizophyllan is a potential candidate as a hepatocyte-targeted antisense carrier.
abstract: A schizophyllan (beta-1,3-glucan) derivative carrying lactose-appendages prepared by reductive amination can form stable macromolecular complexes with polynucleotides, shows excellent affinity with a lactose-binding lectin, and effectively mediates gene transfection into hepatocytes.
authors.affiliation: Department of Chemistry and Biotechnology, Graduate School of Engineering, Kyushu University, Hakozaki 6-10-1, Higashi-ku, Fukuoka 812-8581, Japan.
authors.forename: Teruaki
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Mariko
authors.initials: M
authors.lastname: Umeda
authors.forename: Takahiro
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Munenori
authors.initials: M
authors.lastname: Numata
authors.forename: Masami
authors.initials: M
authors.lastname: Mizu
authors.forename: Kazuya
authors.initials: K
authors.lastname: Koumoto
authors.forename: Kazuo
authors.initials: K
authors.lastname: Sakurai
authors.forename: Seiji
authors.initials: S
authors.lastname: Shinkai
mesh_terms: D000818:Animals; D037263:Asialoglycoprotein Receptor / Q000378:metabolism; D004337:Drug Carriers; D018390:Gene Targeting; D022781:Hepatocytes / Q000378:metabolism*; D007785:Lactose / Q000737:chemistry*; D015394:Molecular Structure; D016376:Oligonucleotides, Antisense / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D011119:Polynucleotides / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D012566:Sizofiran / Q000737:chemistry*
chemical_list: D037263:Asialoglycoprotein Receptor; D004337:Drug Carriers; D016376:Oligonucleotides, Antisense; D011119:Polynucleotides; D012566:Sizofiran; D007785:Lactose