title: Prognostic factors for severe acute respiratory syndrome: a clinical analysis of 165 cases.
abstract: This study analyzes single factors that affect the prognosis of severe acute respiratory syndrome (SARS) and establishes a prognosis model by multivariate analysis. We retrospectively analyzed the clinical features of SARS in 165 clinically confirmed severe cases. Both age and existence of other diseases before SARS were significantly correlated with prognosis (r=0.506 and r=0.457, respectively; P<.001). During the acute phase of SARS, lactate dehydrogenase level, degree of hypoxemia, respiratory rate, alpha -hydroxybutyric dehydrogenase level, creatine kinase isoenzyme-MB, platelet count, and number of involved lobes noted on chest radiographs, and so on, correlated markedly with the prognosis (r=0.257-0.788; P<.05). The multivariate prognosis regression model was associated with degree of hypoxemia and platelet count. The model was defined by the formula Py=1=es/(1+es), where S is [2.490 x degree of hypoxemia]-[0.050 x number of platelets], and it had a high sensitivity (91.67%), specificity (98.33%), and accuracy (96.42%). The model could be used to effectively judge the state of illness and the prognosis.
authors.affiliation: Department of Infectious Diseases, Beijing Infectious Disease Institute of People's Liberation Army, Beijing, China.
authors.forename: Zhengsheng
authors.initials: Z
authors.lastname: Zou
authors.forename: Yongping
authors.initials: Y
authors.lastname: Yang
authors.forename: Jumei
authors.initials: J
authors.lastname: Chen
authors.forename: Shaojie
authors.initials: S
authors.lastname: Xin
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Xianzhi
authors.initials: X
authors.lastname: Zhou
authors.forename: Yuanli
authors.initials: Y
authors.lastname: Mao
authors.forename: Liangping
authors.initials: L
authors.lastname: Hu
authors.forename: Daojian
authors.initials: D
authors.lastname: Liu
authors.forename: Binxia
authors.initials: B
authors.lastname: Chang
authors.forename: Weihua
authors.initials: W
authors.lastname: Chang
authors.forename: Yanping
authors.initials: Y
authors.lastname: Liu
authors.forename: Xuemei
authors.initials: X
authors.lastname: Ma
authors.forename: Yedong
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiqing
authors.initials: X
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003402:Creatine Kinase / Q000378:metabolism; D005260:Female; D006801:Humans; D006884:Hydroxybutyrate Dehydrogenase / Q000378:metabolism; D007677:Kidney Function Tests; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010976:Platelet Count; D011379:Prognosis; D012119:Respiration; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D045169:Severe Acute Respiratory Syndrome / Q000175:diagnosis* / Q000201:enzymology / Q000378:metabolism
chemical_list: D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase; D003402:Creatine Kinase