title: Role of mechanical environment and implant design on bone tissue differentiation: current knowledge and future contexts.
abstract: OBJECTIVE
  To evaluate published evidence related to bone reactions to varying loading regimens and the impact of implant design on bone tissue differentiation.
  
  
  METHODS
  The literature was searched for original research articles relating effect of mechanical environment on bone tissue and effects of implant design on bone biomechanics and marginal bone reactions using MEDLINE and manual tracing of references cited in key papers otherwise not elicited.
  
  
  METHODS
  Current literature on biomechanics of bone and dental implants as main focus and pertinent to key aspects of the review.
  
  
  CONCLUSIONS
  Implant design influences force transmission characteristics in peri-implant bone, but not the time-dependent marginal bone reactions. Mechanical signals affect bone tissue differentiation. Therefore, it is essential to control biomechanical loads on implants to maintain osseointegration and/or to promote early bone-implant interface healing.
authors.affiliation: Department of Prosthodontics, Faculty of Dentistry, Hacettepe University, Ankara, Turkey. mcehreli@hacettepe.edu.tr
authors.forename: Murat
authors.initials: M
authors.lastname: Cehreli
authors.forename: Saime
authors.initials: S
authors.lastname: Sahin
authors.forename: Kivanç
authors.initials: K
authors.lastname: Akça
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D016723:Bone Remodeling; D015921:Dental Implants; D017267:Dental Prosthesis Design; D003799:Dental Stress Analysis; D006801:Humans; D009038:Motion; D013499:Surface Properties; D016474:Weight-Bearing
chemical_list: D015921:Dental Implants