title: Modeling the economic net benefit of a potential vaccination program against ocular infection with Chlamydia trachomatis.
abstract: Trachoma is an ocular infection caused by Chlamydia trachomatis that carries a huge public health burden as a leading cause of preventable blindness globally. We developed a model of the economic benefits of a potential vaccine. Factors that impact the efficacy of a vaccination program (such as the sensitivity and specificity of algorithms to identify high-risk individuals), and personal and environmental risk factors for trachoma affect the maximum vaccination and screening costs at which a vaccination program can achieve a positive net benefit. This model is useful for planning vaccine programs in areas with varying trachoma risk factors and endemicity.
authors.affiliation: Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Health Services Research and Development Center, 624 N Broadway, Room 606, Baltimore, MD 21205, USA. kfrick@jhsph.edu
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Frick
authors.forename: M Arantxa
authors.initials: MA
authors.lastname: Colchero
authors.forename: Deborah
authors.initials: D
authors.lastname: Dean
mesh_terms: D000465:Algorithms; D001766:Blindness / Q000191:economics* / Q000453:epidemiology / Q000517:prevention & control*; D002692:Chlamydia trachomatis / Q000276:immunology*; D003362:Cost-Benefit Analysis; D003663:Decision Trees; D004777:Environment; D006801:Humans; D017589:Immunization Programs / Q000191:economics*; D018803:Models, Economic; D012307:Risk Factors; D014141:Trachoma / Q000191:economics* / Q000453:epidemiology / Q000517:prevention & control*