title: Fluoride and apatite formation in vivo and in vitro.
abstract: In recent years, the biomineralization process has attracted much interest from academics and industries for potential technological application. The rule in biomineralization is to have a variety of interfaces and surfaces which can act as nucleators. The ultimate step in any biomineralization process, i.e. the deposition of mineral, must conform to the driving forces operating on the system. A new paradigm in the assessment of the driving force for biomineralization is that a variety of ions existing in the mineralizing milieu are not a bystander, but are instead an active player that directly regulates the precipitation process and nature of biogenic apatites. Thus, the most putative stoichiometric model of a biomineral is (Ca)(5-x)(Mg)q(Na)u(HPO4)v(CO3)w(PO4)(3-y)(OH,F)(1-z). Fluoride participates in many aspects of calcium phosphate formation in vivo and has enormous effects on its process and on the nature and properties of the final products. In the development of biogenic apatites, fluoride ion in the mineralizing media is supposed to accelerate the hydrolysis of acidic precursor(s) and increase the growth rates by augmenting the driving force for precipitation. Inhibitory activities of ions and molecules are related to their adsorption onto the apatite surfaces. From theoretical and practical points of view, it is of paramount importance to elucidate and predict the effect and outcome of fluoride (accelerator) and inhibitors of biological relevance, because of their use in combination for healthcare in dentistry and medicine, e.g. prevention of dental caries and calculus deposition and in the formulation of antiosteoporosis treatments.
authors.affiliation: Nippon Dental University, Department of Pathology, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8158, Japan. pathology-ndu@tokyo.ndu.ac.jp
authors.forename: Takaaki
authors.initials: T
authors.lastname: Aoba
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Shimazu
authors.forename: Yuji
authors.initials: Y
authors.lastname: Taya
authors.forename: Yuuichi
authors.initials: Y
authors.lastname: Soeno
authors.forename: Kaori
authors.initials: K
authors.lastname: Sato
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Miake
mesh_terms: D000818:Animals; D001031:Apatites / Q000737:chemistry*; D002113:Calcification, Physiologic; D003460:Crystallization; D018940:Elasmobranchii / Q000502:physiology; D005459:Fluorides / Q000494:pharmacology*; D006801:Humans; D007448:Invertebrates / Q000502:physiology
chemical_list: D001031:Apatites; D005459:Fluorides