title: Effects of altered crystalline structure and increased initial compressive strength of calcium sulfate bone graft substitute pellets on new bone formation.
abstract: A new, modified calcium sulfate has been developed with a different crystalline structure and a compressive strength similar to many calcium phosphate materials, but with a resorption profile only slightly slower than conventional surgical-grade calcium sulfate. A canine bilateral defect model was used to compare restoration of defects treated with the modified calcium sulfate compared to treatment using conventional calcium sulfate pellets after 6, 13, and 26 weeks. The modified calcium sulfate pellets were as effective as conventional calcium sulfate pellets with regard to the area fraction and compressive strength of newly formed bone in the treated bone defects. Mechanical testing demonstrated that the initial compressive strength of the modified material was increased nearly three-fold compared to that of conventional surgical-grade calcium sulfate. This increase potentially allows for its use in a broader range of clinical applications, such as vertebral and subchondral defects.
authors.affiliation: Department of Orthopedic Surgery, Rush University Medical Center, Chicago, Ill, USA.
authors.forename: Robert M
authors.initials: RM
authors.lastname: Urban
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Turner
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Hall
authors.forename: Susan I
authors.initials: SI
authors.lastname: Infanger
authors.forename: Naveed
authors.initials: N
authors.lastname: Cheema
authors.forename: Tae-Hong
authors.initials: TH
authors.lastname: Lim
authors.forename: Jon
authors.initials: J
authors.lastname: Moseley
authors.forename: Michael
authors.initials: M
authors.lastname: Carroll
authors.forename: Michael
authors.initials: M
authors.lastname: Roark
mesh_terms: D000818:Animals; D018786:Bone Substitutes / Q000737:chemistry; D002133:Calcium Sulfate; D019245:Compressive Strength; D003460:Crystallization; D004285:Dogs; D008297:Male; D008422:Materials Testing; D010012:Osteogenesis
chemical_list: D018786:Bone Substitutes; D002133:Calcium Sulfate