[Membrane mechanisms of effects of antihypoxic agents bemethyl and almide on neurons of Mollusca].
Membranotropic effects of the antihypoxants bemithyl and almide, structural analogs of thiobenzimidazole, have been studied on the isolated neuronal preparations of Lymaea stagnalis branchycephalic mollusk. Both drugs in a concentration range of 100-1000 microM produced a reversible, dose-dependent nonselective single-phase blocking action upon the ion channels and completely blocked the channels at a concentration of 10 mM. Therefore, bemithyl and almide are active membranotropic compounds capable (in sufficiently high concentrations) of changing the conductivity of slow sodium, calcium, and potassium ion channels in excitable cells. The protective antihypoxant drug reactions on a systemic level of the organism are probably related to the fact that both drugs in small concentrations are capable of hyperpolarizing the cell membrane, activating the ion channel function, and stabilizing the action potential under hypoxia conditions; in greater concentrations, bemithyl and almide are capable of blocking ion currents, thus reducing the excitability of cells and protecting them from overstress.
Vislobokov
A I
AI
St. Petersburg State Military Medical Academy, Ministry of Defense of the Russian Federation, ul. Lebedeva 6, St. Petersburg, 194044 Russia.
Marysheva
V V
VV
Shabanov
P D
PD
D000498:Allyl Compounds / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015687:Cell Hypoxia / Q000187:drug effects; D004594:Electrophysiology; D017952:Ganglia, Invertebrate / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D007473:Ion Channels / Q000037:antagonists & inhibitors* / Q000502:physiology; D008195:Lymnaea; D026902:Potassium Channel Blockers / Q000494:pharmacology; D026941:Sodium Channel Blockers / Q000494:pharmacology
D000498:Allyl Compounds; D000975:Antioxidants; D001562:Benzimidazoles; D002121:Calcium Channel Blockers; D007473:Ion Channels; D026902:Potassium Channel Blockers; D026941:Sodium Channel Blockers; C488150:almide; C049825:bemethyl