title: [The role of platelet glycoprotein receptors and their ligands: fibrinogen and von Willebrand factor in arterial thrombosis].
abstract: The arterial platelet thrombus contribute to development of thrombotic complications of atherosclerosis: acute coronary syndrome, thrombotic strokes and exacerbations of peripheral arterial occlusive disease. Platelet adhesion and aggregation is mediated by interaction between platelet glycoprotein receptors GPI b/IX GPII b/III a and their ligands-adhesive proteins: von Willebrand factor (vWF) and/or fibrinogen. Pharmacological blockade of interaction between glycoproteins receptor and their ligands may offer an effective prevention of thrombotic complications.
authors.affiliation: Katedra i Klinika Angiologii, Nadciśnienia Tetniczego i Diabetologii 50-326 Wrocław, ul. Poniatowskiego 2.
authors.forename: Izabela
authors.initials: I
authors.lastname: Gosk-Bierska
authors.forename: Rajmund
authors.initials: R
authors.lastname: Adamiec
mesh_terms: D003328:Coronary Thrombosis / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008024:Ligands; D010980:Platelet Membrane Glycoproteins / Q000502:physiology*; D014841:von Willebrand Factor / Q000378:metabolism*
chemical_list: D008024:Ligands; D010980:Platelet Membrane Glycoproteins; D014841:von Willebrand Factor; D005340:Fibrinogen