Two new analogues of the cytotoxic substance BE-52211 from Streptomyces sp.
Two new beta-hydroxy acetamides, BE-52211 B and BE-52211 C, which were structural analogues of BE-52211, were obtained as an inseparable mixture from an actinomycete, Streptomyces sp. Their structures were elucidated on the basis of spectroscopic data. They inhibited cell division of starfish embryos at a concentration of 2.5 microg/mL or greater.
Kubota
Natsuki K
NK
Instrument Center for Chemical Analysis, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan.
Ohta
Shinji
S
Ohta
Emi
E
Koizumi
Fumito
F
Suzuki
Makoto
M
Ichimura
Michio
M
Rahayu
Endang S
ES
Ikegami
Susumu
S
D000081:Acetamides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004625:Embryo, Nonmammalian / Q000187:drug effects; D007214:Indonesia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013215:Starfish / Q000187:drug effects; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry*
D000081:Acetamides; C483278:BE52211; C483279:BE52211 B; C483280:BE52211 C; D003603:Cytotoxins