title: The different role of Cu++ and Zn++ ions in affecting the interaction of prion peptide PrP106-126 with model membranes.
abstract: Differential scanning calorimetric (DSC) experiments have shown that the ability of PrP106-126 to perturb 1,3-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) model membranes is differently affected by Cu(++) and Zn(++) ions.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Catania, Viale Andrea Doria, 6 95125 Catania, Italy. dgrasso@dipchi.unict.it
authors.forename: Domenico
authors.initials: D
authors.lastname: Grasso
authors.forename: Danilo
authors.initials: D
authors.lastname: Milardi
authors.forename: Carmelo
authors.initials: C
authors.lastname: La Rosa
authors.forename: Enrico
authors.initials: E
authors.lastname: Rizzarelli
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002413:Cations, Divalent; D003300:Copper / Q000737:chemistry*; D005782:Gels / Q000737:chemistry; D008563:Membrane Lipids / Q000737:chemistry; D008567:Membranes, Artificial; D010446:Peptide Fragments / Q000737:chemistry*; D011328:Prions / Q000737:chemistry*; D013696:Temperature; D015032:Zinc / Q000737:chemistry*
chemical_list: D002413:Cations, Divalent; D005782:Gels; D008563:Membrane Lipids; D008567:Membranes, Artificial; D010446:Peptide Fragments; D011328:Prions; C082632:prion protein (106-126); D015060:1,2-Dipalmitoylphosphatidylcholine; D003300:Copper; D015032:Zinc