Hyperplasia, partial hepatectomy, and the carcinogenicity of aflatoxin B1.
Generalized cellular hyperplasia has long been associated as a factor in the causation of liver cancer. Parenchymal cell hyperplasia resulting from hepatotoxins, viruses, parasites, or malnutrition is exceedingly variable as to when it occurs, its extent, and its duration. Partial hepatectomy has been used as an experimental tool precisely because the timing and extent of hyperplasia can be known and controlled. With regards to aflatoxin B1 (AFB1) carcinogenesis, partial hepatectomy has produced variable results. An explanation appears to reside in the hepatotoxic properties of AFB1 that enhance the early stages of carcinogenesis.
Roebuck
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BD
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA. Bill.D.Roebuck@Dartmouth.edu
D016604:Aflatoxin B1 / Q000633:toxicity*; D000818:Animals; D001835:Body Weight; D002273:Carcinogens / Q000633:toxicity*; D006498:Hepatectomy; D006965:Hyperplasia; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008114:Liver Neoplasms, Experimental / Q000209:etiology*; D008115:Liver Regeneration / Q000187:drug effects; D051381:Rats
D002273:Carcinogens; D016604:Aflatoxin B1