The biological basis of Hodgkin's lymphoma.
In the past several years our understandings for Hodgkin's lymphoma have significantly progressed, and we can now recognize two fundamental bases of Hodgkin's lymphoma: germinal center B cells as a cellular origin of Hodgkin and Reed-Sternberg (H-RS) cells and constitutively strong NF-kappaB activation as a biological base for H-RS cells. We can also define Hodgkin's lymphoma as being composed of H-RS cells with self-growth-promoting potential as malignant cells by constitutively strong NF-kappaB activation and surrounding reactive cells. Identification of molecules involved in constitutive and strong NF-kappaB activation in H-RS cells is important to understand the pathophysiology as well as transformation and developmental process of Hodgkin's lymphoma. Epstein-Barr virus latent membrane protein (LMP)-1, defective IkappaBalpha, IkappaB kinase activation and ligand-independent signaling by overexpressed CD30 have been clarified in the past several years. Involvement of JunB in overexpression of CD30 has been recently reported. Today, over a century and a half after the first report by Thomas Hodgkin, we at last obtained several keys to solving the mystery of Hodgkin's lymphoma on a biological basis.
Horie
Ryouichi
R
Division of Pathology, Department of Cancer Research, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. rhorie@med.kitasato-u.ac.jp
Watanabe
Toshiki
T
D000818:Animals; D002470:Cell Survival; D006689:Hodgkin Disease / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D017730:Ki-1 Antigen / Q000096:biosynthesis; D016328:NF-kappa B / Q000819:agonists* / Q000378:metabolism; D016539:Reed-Sternberg Cells / Q000378:metabolism / Q000473:pathology
D017730:Ki-1 Antigen; D016328:NF-kappa B