Cell death: critical control points.
Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans. An intact death pathway is required for successful embryonic development and the maintenance of normal tissue homeostasis. Apoptosis has proven to be tightly interwoven with other essential cell pathways. The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics.
Danial
Nika N
NN
Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
Korsmeyer
Stanley J
SJ
D000818:Animals; D017209:Apoptosis; D053477:Apoptotic Protease-Activating Factor 1; D017173:Caenorhabditis elegans; D002154:Calpain / Q000378:metabolism; D016923:Cell Death; D004247:DNA / Q000378:metabolism; D004330:Drosophila; D004721:Endoplasmic Reticulum / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D009336:Necrosis; D011506:Proteins / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D012697:Serine Endopeptidases / Q000378:metabolism; D015398:Signal Transduction
C506592:APAF1 protein, human; D053477:Apoptotic Protease-Activating Factor 1; D011506:Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D004247:DNA; D012697:Serine Endopeptidases; D002154:Calpain