title: MicroRNAs: genomics, biogenesis, mechanism, and function.
abstract: MicroRNAs (miRNAs) are endogenous approximately 22 nt RNAs that can play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression. Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
authors.affiliation: Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA. dbartel@wi.mit.edu
authors.forename: David P
authors.initials: DP
authors.lastname: Bartel
mesh_terms: D000818:Animals; D001483:Base Sequence; D017173:Caenorhabditis elegans; D004330:Drosophila; D016678:Genome; D006801:Humans; D035683:MicroRNAs / Q000502:physiology*; D008954:Models, Biological; D008969:Molecular Sequence Data; D010641:Phenotype; D010940:Plant Proteins / Q000502:physiology; D014176:Protein Biosynthesis; D034741:RNA, Small Interfering / Q000378:metabolism; D013045:Species Specificity; D014158:Transcription, Genetic
chemical_list: D035683:MicroRNAs; D010940:Plant Proteins; D034741:RNA, Small Interfering