Adenosine receptors and wound healing.
Recent studies have demonstrated that application of topical adenosine A2A receptor agonists promotes more rapid wound closure and clinical studies are currently underway to determine the utility of topical A2A adenosine receptor agonists in the therapy of diabetic foot ulcers. The effects of adenosine A2A receptors on the cells and tissues of healing wounds have only recently been explored. We review here the known effects of adenosine A2A receptor occupancy on the cells involved in wound healing.
Cronstein
Bruce N
BN
Department of Pathology, New York University School of Medicine, New York, 10016, USA. cronsb01@med.nyu.edu
D000241:Adenosine / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use; D058908:Adenosine A2 Receptor Agonists; D000818:Animals; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D007249:Inflammation / Q000188:drug therapy; D051379:Mice; D018919:Neovascularization, Physiologic; D058906:Purinergic P1 Receptor Agonists; D014945:Wound Healing / Q000187:drug effects* / Q000276:immunology
D058908:Adenosine A2 Receptor Agonists; D058906:Purinergic P1 Receptor Agonists; D000241:Adenosine