title: Effect of interstitial stereotactic radiosurgery on behavior and subjective handicap of epilepsy in patients with gelastic epilepsy.
abstract: Patients with symptomatic epilepsy due to hypothalamic hamartomas often are compromised not only by pharmacoresistant epileptic seizures but also by behavioral disturbances and cognitive dysfunction. We report the effect of successful treatment with stereotactic interstitial radiosurgery by intrahypothalamic implantation of 125I seeds on behavior and subjective handicap. In all patients rendered seizure-free or suffering only from auras, improvement of behavior was reported by parents and colleagues or schoolteachers. Parents' ratings according to the Child Behavior Checklist showed improvements with respect to social problems and attention. Self-ratings of quality of life by adult patients showed improvements in activities, working situation, and self-perception. These improvements were not observed in patients in whom clinically manifest seizures and interictal EEG discharges persisted after radiosurgery.
authors.affiliation: Epilepsy Centre, University of Freiburg, Freiburg, Germany. schulzeb@nz.ukl.uni-freiburg.de
authors.forename: A
authors.initials: A
authors.lastname: Schulze-Bonhage
authors.forename: A
authors.initials: A
authors.lastname: Quiske
authors.forename: V
authors.initials: V
authors.lastname: Homberg
authors.forename: M
authors.initials: M
authors.lastname: Trippel
authors.forename: K
authors.initials: K
authors.lastname: Wagner
authors.forename: L
authors.initials: L
authors.lastname: Frings
authors.forename: T
authors.initials: T
authors.lastname: Bast
authors.forename: H-J
authors.initials: HJ
authors.lastname: Huppertz
authors.forename: C
authors.initials: C
authors.lastname: Warnke
authors.forename: Ch
authors.initials: Ch
authors.lastname: Ostertag
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D001288:Attention; D001519:Behavior / Q000528:radiation effects*; D002648:Child; D006233:Persons with Disabilities; D004569:Electroencephalography / Q000528:radiation effects; D004828:Epilepsies, Partial / Q000150:complications / Q000601:surgery*; D005500:Follow-Up Studies; D006222:Hamartoma / Q000601:surgery; D006801:Humans; D007029:Hypothalamic Neoplasms; D007031:Hypothalamus / Q000528:radiation effects / Q000601:surgery; D007361:Intelligence Tests; D007456:Iodine Isotopes; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders / Q000150:complications; D019635:Neurosurgical Procedures; D017060:Patient Satisfaction; D016634:Radiosurgery / Q000009:adverse effects*; D012919:Social Behavior; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D007456:Iodine Isotopes