title: Inhibition of the proliferation of a malignant peripheral nerve sheath tumor cell line by gamma interferon gene transfection.
abstract: A solitary malignant peripheral nerve sheath tumor was resected, and a tumor cell line was obtained using an explant culture. The morphology of this cell line was quite similar to those of cell lines of dermal neurofibromas of neurofibromatosis 1, except for the fact that the malignant peripheral nerve sheath tumor cell line could be cultured for more than two months. When the tumor cell line was transfected with human gamma interferon gene, the growth rate was remarkably abolished, as previously observed in neurofibroma cell lines transfected with the gamma interferon gene. This new finding suggests the potential for treating either solitary or neurofibroma-related, inoperable, malignant peripheral nerve sheath tumors by local gamma interferon gene transfection in vivo.
authors.affiliation: Department of Dermatology, Fukuoka University School of Medicine, Fukuoka, Japan.
authors.forename: Juichiro
authors.initials: J
authors.lastname: Nakayama
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tanaka
authors.forename: Minao
authors.initials: M
authors.lastname: Furumura
authors.forename: Akira
authors.initials: A
authors.lastname: Takahashi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Hideo
authors.initials: H
authors.lastname: Shimura
authors.forename: Seiyo
authors.initials: S
authors.lastname: Ikeda
authors.forename: Masahide
authors.initials: M
authors.lastname: Kuroki
mesh_terms: D000368:Aged; D002455:Cell Division / Q000187:drug effects / Q000235:genetics; D045744:Cell Line, Tumor / Q000187:drug effects; D015316:Genetic Therapy; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics / Q000494:pharmacology*; D008297:Male; D009456:Neurofibromatosis 1 / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D010524:Peripheral Nervous System Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D014162:Transfection
chemical_list: D007371:Interferon-gamma