Suzuki cross-couplings of unactivated secondary alkyl bromides and iodides.
The capacity to employ unactivated alkyl electrophiles as coupling partners will markedly increase the already exceptional utility of metal-catalyzed cross-coupling processes. This communication describes the development of a method that achieves the first Suzuki reactions of unactivated secondary alkyl bromides and iodides. The ability to couple readily available, easy-to-handle boronic acids is an attractive feature of this catalyst system.
Zhou
Jianrong
J
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Fu
Gregory C
GC
D000473:Alkanes / Q000138:chemical synthesis*; D001897:Boronic Acids / Q000737:chemistry; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry; D010165:Palladium / Q000737:chemistry
D000473:Alkanes; D001897:Boronic Acids; D006842:Hydrocarbons, Brominated; D006847:Hydrocarbons, Iodinated; D009942:Organometallic Compounds; D010165:Palladium; D009532:Nickel