title: [Insulin resistance in polycystic ovary syndrome].
abstract: With a prevalence of 5-10% the polycystic ovary syndrome (PCOS) is a common disorder of premenopausal women. According to prospective studies abnormal glucose tolerance and diabetes mellitus present in about 10.0% and 35.0% of adult women with PCOS, respectively. PCOS patients have a higher prevalence of cardiovascular risk factors such as hypertension and dyslipidaemia. The rate of spontaneous abortions as well as the risk of developing gestational diabetes is increased in PCOS. Therefore, PCOS is not only a reproductive problem, but a complex endocrine disease with important health implications. The role of glucose metabolism in PCOS, the health consequences and possible interventions are reviewed in this article.
authors.affiliation: Klinik für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Schleswig-Hostein, Campus Lübeck, Lübeck, Deutschland.
authors.forename: Annika K
authors.initials: AK
authors.lastname: Schröder
authors.forename: Sascha
authors.initials: S
authors.lastname: Tauchert
authors.forename: Olaf
authors.initials: O
authors.lastname: Ortmann
authors.forename: Klaus
authors.initials: K
authors.lastname: Diedrich
authors.forename: Jürgen M
authors.initials: JM
authors.lastname: Weiss
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology; D002839:Chromans / Q000627:therapeutic use; D018849:Controlled Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000209:etiology; D016640:Diabetes, Gestational / Q000209:etiology; D005260:Female; D005947:Glucose / Q000378:metabolism; D018149:Glucose Intolerance; D005951:Glucose Tolerance Test; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007231:Infant, Newborn; D007247:Infertility, Female / Q000209:etiology; D007333:Insulin Resistance; D008687:Metformin / Q000627:therapeutic use; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D010919:Placebos; D011085:Polycystic Ovary Syndrome / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy; D017697:Premenopause; D015995:Prevalence; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D045162:Thiazolidinediones / Q000627:therapeutic use; D000077288:Troglitazone
chemical_list: D002839:Chromans; D007004:Hypoglycemic Agents; D010919:Placebos; D045162:Thiazolidinediones; D008687:Metformin; D000077288:Troglitazone; D005947:Glucose