Acute impact of submaximal resistance exercise on immunological and hormonal parameters in young men.
In this study, we examined the acute effects of submaximal resistance exercise on immunological and hormonal parameters in 7 resistance-trained and 10 non-resistance-trained males. The participants, who were aged 29.5 +/- 7.1 years (mean +/- s), performed submaximal resistance exercise at 75% of their one-repetition maximum. Blood samples were taken before, during, immediately after, and 30, 60 and 120 min after exercise and analysed for leukocyte subpopulations and stress hormones. Total leukocytes, neutrophils and monocytes increased during exercise, reaching their maximum 2 h after exercise. Lymphocytes increased during exercise, T-helper cells returned to resting values after exercise, and natural killer cells and T-suppressor cells decreased below resting values. The CD4/CD8 ratio decreased during exercise but increased during recovery. The resistance-trained participants tended to have lower T-helper cell counts before, during and immediately after exercise and a lower CD4/CD8 ratio during recovery than the non-resistance-trained participants. Plasma cortisol correlated positively with leukocytes during exercise (r = 0.572, P < 0.05), but negatively with T-helper cells 30 and 60 min after exercise (r = -0.573, P < 0.05; r = -0.642, P < 0.01, respectively). Our results indicate that resistance exercise leads to acute changes in leukocyte counts, despite moderate hormonal changes, independent of training status. Regular resistance exercise might lead to decreased T-helper cell counts and a lower CD4/CD8 ratio, which could increase susceptibility to infections.
Ramel
Alfons
A
Unit for Nutrition Research, University of Iceland, PO Box Nyi Gardur, IS-101 Reykjavik, Iceland. ramel@hi.is
Wagner
Karl-Heinz
KH
Elmadfa
Ibrahim
I
D000328:Adult; D016516:CD4-CD8 Ratio; D006400:Hematocrit; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007694:Killer Cells, Natural / Q000502:physiology*; D007958:Leukocyte Count; D018655:Lymphocyte Count; D008297:Male; D009000:Monocytes / Q000502:physiology*; D009504:Neutrophils / Q000502:physiology*; D009638:Norepinephrine / Q000097:blood; D010806:Physical Education and Training / Q000379:methods*; D012016:Reference Values; D006377:T-Lymphocytes, Helper-Inducer / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*; D013997:Time Factors
D006854:Hydrocortisone; D009638:Norepinephrine