title: Correlation between serum vascular endothelial growth factor and endostatin levels in patients with breast cancer.
abstract: Serum vascular endothelial growth factor (VEGF) and endostatin levels were detected in 59 patients with breast cancer before surgery and at 3 weeks after surgery. Pre-operatively, their levels were significantly elevated and correlated with each other. Post-operatively, VEGF level decreased significantly and endostatin remained at a high level. Patients with both normalized VEGF and elevated endostatin following surgery had a lower risk of relapse than patients whose VEGF failed to normalize. Univariate and multivariate analyses showed a correlation between elevated VEGF level and short free-relapse survival. These findings suggest a new angiogenesis balance is formed in the patients after surgery and such a resultant balance may be beneficial for the prognosis of breast cancer, which deserves more extensive study.
authors.affiliation: Center of Clinical Laboratory Science, Jiangsu Institute of Cancer Research, Nanjing 210009, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhao
authors.forename: Feng
authors.initials: F
authors.lastname: Yan
authors.forename: Huangxian
authors.initials: H
authors.lastname: Ju
authors.forename: Jinhai
authors.initials: J
authors.lastname: Tang
authors.forename: Jianwei
authors.initials: J
authors.lastname: Qin
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood* / Q000401:mortality / Q000601:surgery; D016022:Case-Control Studies; D018572:Disease-Free Survival; D043169:Endostatins / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood*; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D043169:Endostatins; D042461:Vascular Endothelial Growth Factor A