Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis.
We have recently reported the presence of the anxiolytic flavone 6-methylapigenin (MA) and of the sedative and sleep-enhancing flavanone glycoside 2S (-) hesperidin (HN) in Valeriana officinalis and Valeriana wallichii. MA, in turn, was able to potentiate the sleep-inducing properties of HN. The present paper reports the identification in V. officinalis of the flavone glycoside linarin (LN) and the discovery that it has, like HN, sedative and sleep-enhancing properties that are potentiated by simultaneous administration of valerenic acid (VA). These effects should be taken into account when considering the pharmacological actions of valeriana extracts.
Fernández
Sebastián
S
Instituto de Química y Fisicoquímica Biológicas, Facultad de Farmacia y Bioquímica, Junín 956 (1113), Buenos Aires, Argentina.
Wasowski
Cristina
C
Paladini
Alejandro C
AC
Marder
Mariel
M
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D004357:Drug Synergism; D005445:Flunitrazepam / Q000493:pharmacokinetics; D018757:GABA Modulators / Q000493:pharmacokinetics; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D006993:Hypnotics and Sedatives; D007192:Indenes / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012717:Sesquiterpenes / Q000302:isolation & purification / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects*; D013056:Spectrophotometry, Ultraviolet; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D013874:Thiopental / Q000494:pharmacology; D014632:Valerian / Q000737:chemistry*
D018757:GABA Modulators; D006027:Glycosides; D006993:Hypnotics and Sedatives; D007192:Indenes; D010936:Plant Extracts; D012717:Sesquiterpenes; C037133:valerenic acid; D005445:Flunitrazepam; C008282:linarin; D013874:Thiopental