title: Why rest stimulates bone formation: a hypothesis based on complex adaptive phenomenon.
abstract: Moderate exercise is an ineffective strategy to build bone mass. The authors present data demonstrating that allowing bone to rest between each load cycle transforms low- and moderate-magnitude mechanical loading into a signal that potently induces bone accretion. They hypothesize that the osteogenic nature of rest-inserted loading arises by enabling osteocytes to communicate as a small world network.
authors.affiliation: Orthopaedic Science Laboratories, Department of Orthopaedics and Sports Medicine, University of Washington, Seattle 98107, USA. tgross@u.washington.edu
authors.forename: Ted S
authors.initials: TS
authors.lastname: Gross
authors.forename: Sandra L
authors.initials: SL
authors.lastname: Poliachik
authors.forename: Brandon J
authors.initials: BJ
authors.lastname: Ausk
authors.forename: David A
authors.initials: DA
authors.lastname: Sanford
authors.forename: Blair A
authors.initials: BA
authors.lastname: Becker
authors.forename: Sundar
authors.initials: S
authors.lastname: Srinivasan
mesh_terms: D000222:Adaptation, Physiological; D015444:Exercise / Q000502:physiology*; D006801:Humans; D009142:Musculoskeletal Physiological Phenomena; D010011:Osteocytes / Q000378:metabolism / Q000502:physiology; D010012:Osteogenesis / Q000502:physiology*; D012146:Rest / Q000502:physiology*; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D016474:Weight-Bearing