title: Voriconazole in fungal keratitis caused by Scedosporium apiospermum.
abstract: OBJECTIVE
  To describe the first case, to the best of our knowledge, of posttraumatic Scedosporium apiospermum (ScA) keratitis successfully treated with systemic and topical voriconazole.
  
  
  METHODS
  A 19-year-old man was admitted to the hospital with an incisive wound of his left eye and the cornea totally sectioned after trauma with a cutter used in gardening. Initial empirical treatment was followed by systemic and topical voriconazole, and the eye did not have to be enucleated. Five months after the trauma, a penetrating keratoplasty and chamber intraocular lens implantation was performed with a favorable visual outcome.
  
  
  CONCLUSIONS
  ScA keratitis is rare, but it must be suspected if a history of ocular injury with contaminated objects exists. Among the antifungals available to treat ScA keratitis, voriconazole has shown advantages such as the lowest minimum inhibitory concentration and the availability of an oral formulation.
  
  
  CONCLUSIONS
  Voriconazole shows promise as an effective alternative to conventional antifungals in the treatment of ScA keratitis. It is available both as oral and intravenous preparations, which is a great advantage in these lengthy infections.
authors.affiliation: Pharmacy Department, Alicante University General Hospital, Alicante, Spain. fgtorregrosa@terra.es
authors.forename: Carmen
authors.initials: C
authors.lastname: Hernández Prats
authors.forename: Francisca
authors.initials: F
authors.lastname: Llinares Tello
authors.forename: Amparo
authors.initials: A
authors.lastname: Burgos San José
authors.forename: Juan
authors.initials: J
authors.lastname: Selva Otaolaurruchi
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Ordovás Baines
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D005131:Eye Injuries / Q000382:microbiology*; D006801:Humans; D007634:Keratitis / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D011743:Pyrimidines / Q000627:therapeutic use*; D021681:Scedosporium; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole