title: Isotamarixen - a new antioxidant and prolyl endopeptidase-inhibiting triterpenoid from Tamarix hispida.
abstract: A new pentacyclic triterpenoid, 3alpha-(3",4"-dihydroxy- trans-cinnamoyloxy)- D-friedoolean-14-en-28-oic acid ( 1) has been isolated along with two known compounds, rhamnocitrin ( 2) and isorhamnetin ( 3) from the aerial parts of Tamarix hispida Willd. Compound 1 was found to be a potent antioxidant. In addition, compounds 1 - 3 showed significant inhibitory activity against prolylendopeptidase (PEP).
authors.affiliation: HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan.
authors.forename: Nurgul
authors.initials: N
authors.lastname: Sultanova
authors.forename: Talat
authors.initials: T
authors.lastname: Makhmoor
authors.forename: Amsha
authors.initials: A
authors.lastname: Yasin
authors.forename: Z A
authors.initials: ZA
authors.lastname: Abilov
authors.forename: V B
authors.initials: VB
authors.lastname: Omurkamzinova
authors.lastname: Atta-ur-Rahman
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D008517:Phytotherapy; D010851:Picrates / Q000737:chemistry; D035261:Plant Components, Aerial; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000187:drug effects*; D032363:Tamaricaceae; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; C483063:Isotamarixen; D010851:Picrates; D014315:Triterpenes; C004931:1,1-diphenyl-2-picrylhydrazyl; D012697:Serine Endopeptidases; C000705287:PREPL protein, human; D000085822:Prolyl Oligopeptidases