title: Role of some fermentation parameters on cyclosporin A production by a new isolate of Aspergillus terreus.
abstract: A local isolate of Aspergillus terreus was selected among different microorganisms as a new cyclosporin A (Cy A) producing culture. The formation of Cy A was investigated under different fermentation conditions (including selection of the cultivation medium, fermentation time course, inoculum nature, medium volume, agitation rate, pH value). Relatively high Cy A productivities were maintained when the fermentation process was carried out using a medium composed of (g/L): glucose, 50; bactopeptone, 10; KH(2)PO(4), 5; KCl, 2.5; pH 5.3, inoculated with 2% standard inoculum of 48 h age, shaken at 200 rpm for 10 days.
authors.affiliation: Microbial and Natural Products Chemistry Department, National Research Centre, Dokki, Cairo, Egypt.
authors.forename: Lotfy A R
authors.initials: LA
authors.lastname: Sallam
authors.forename: Abdel-Monem H
authors.initials: AM
authors.lastname: El-Refai
authors.forename: Abdel-Hamid A
authors.initials: AH
authors.lastname: Hamdy
authors.forename: Hassaan A
authors.initials: HA
authors.lastname: El-Minofi
authors.forename: Ibrahim S
authors.initials: IS
authors.lastname: Abdel-Salam
mesh_terms: D001230:Aspergillus / Q000145:classification / Q000254:growth & development / Q000302:isolation & purification / Q000502:physiology*; D018533:Biomass; D016572:Cyclosporine / Q000378:metabolism*; D004534:Egypt; D005285:Fermentation; D007700:Kinetics; D013045:Species Specificity
chemical_list: D016572:Cyclosporine