[Functional features of actinin and tropomyosin distribution in rat kidney].
The intrarenal distribution of actinin and tropomyosin was studied by western blot analysis in various functional conditions. It was found that actinin content is always higher in cortex than in medulla. The highest tropomyosin content was revealed in outer medulla, but it is more than twice higher in rats of mutant Brattleboro line versus hydrated normal WAG rats. This ratio rises up to 46.12 +/- 2.14 versus 13.83 +/- 0.66 (in relative units) for rats being under dehydration that maximally activated vasopressin secretion in normal WAG rats.
Khegaĭ
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Institute of Cytology and Genetics, SD RAS, 630090 Novosibirsk, Lavrentiev av., 10, Russia.
D000185:Actinin / Q000378:metabolism*; D000818:Animals; D015153:Blotting, Western; D003681:Dehydration; D007668:Kidney / Q000033:anatomy & histology / Q000378:metabolism*; D007672:Kidney Cortex / Q000378:metabolism; D007679:Kidney Medulla / Q000378:metabolism; D051381:Rats; D011910:Rats, Brattleboro; D011919:Rats, Inbred Strains; D012076:Renal Agents / Q000494:pharmacology; D014018:Tissue Distribution / Q000187:drug effects; D014335:Tropomyosin / Q000378:metabolism*; D014667:Vasopressins / Q000494:pharmacology
D012076:Renal Agents; D014335:Tropomyosin; D014667:Vasopressins; D000185:Actinin