title: Clinical and MRI outcome after autologous hematopoietic stem cell transplantation in MS.
abstract: The authors report the outcome of 14 patients with severe multiple sclerosis treated with autologous hematopoietic stem cell transplantation (AHSCT) after a median follow-up period of 3 years. The 3-year actuarial probability of progression-free survival was 85.7% and that of disease activity-free survival was 46.4%. On MRI, no T1-enhanced lesions were detected after AHSCT. The mean change in T2 lesion volume from baseline to the third year was -20.2% and that of the corpus callosum area was -12.7%; 50% of this reduction was seen during the first year.
authors.affiliation: Services of Neurology, Hospital Clínic, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Saiz
authors.forename: Y
authors.initials: Y
authors.lastname: Blanco
authors.forename: E
authors.initials: E
authors.lastname: Carreras
authors.forename: J
authors.initials: J
authors.lastname: Berenguer
authors.forename: M
authors.initials: M
authors.lastname: Rovira
authors.forename: T
authors.initials: T
authors.lastname: Pujol
authors.forename: P
authors.initials: P
authors.lastname: Marín
authors.forename: T
authors.initials: T
authors.lastname: Arbizu
authors.forename: F
authors.initials: F
authors.lastname: Graus
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D001284:Atrophy; D001921:Brain / Q000473:pathology; D003337:Corpus Callosum / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology / Q000628:therapy*; D011446:Prospective Studies; D019172:Transplantation Conditioning / Q000009:adverse effects; D014182:Transplantation, Autologous; D016896:Treatment Outcome