title: Natalizumab. Elan/Biogen.
abstract: Natalizumab is a humanized monoclonal antibody to alpha 4 beta 1 integrin (VLA-4) currently under development by Elan and Biogen for the treatment of Crohn's disease and multiple sclerosis. Phase II trials in both indications have been completed, and by December 2002 phase III trials in Crohn's disease and multiple sclerosis had been initiated.
authors.affiliation: PharmaMar USA, 320 Putnam Avenue, Cambridge, MA 02139, USA. melices@pharmamarusa.com
authors.forename: Mariano J
authors.initials: MJ
authors.lastname: Elices
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D003424:Crohn Disease / Q000188:drug therapy*; D006207:Half-Life; D006801:Humans; D009103:Multiple Sclerosis / Q000188:drug therapy*; D000069442:Natalizumab; D016032:Randomized Controlled Trials as Topic; D013329:Structure-Activity Relationship; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000069442:Natalizumab