Effect of intra-arterial cisplatin on multiple liver metastases from rectal cancer associated with ulcerative colitis.
We report a patient with synchronous multiple liver metastases from rectal cancer associated with ulcerative colitis. Because the liver tumors were unresectable, we performed total proctocolectomy and hepatic intra-arterial cisplatin infusion with systemic oral administration of fluorouracil. A complete response was obtained. The patient is alive without sign of recurrence 5 years postoperatively. Hepatic intra-arterial administration of cisplatin should be considered in the treatment of unresectable liver metastases from colorectal cancer.
Shibata
Chikashi
C
Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan. cshibata@gonryo.med.tohoku.ac.jp
Jin
Xue-Lin
XL
Funayama
Yuji
Y
Fukushima
Kouhei
K
Takahashi
Ken-Ichi
K
Hashimoto
Akihiko
A
Nagao
Munenori
M
Haneda
Sho
S
Watanabe
Kazuhiro
K
Matsuno
Seiki
S
Sasaki
Iwao
I
Naito
Hiroo
H
D000230:Adenocarcinoma / Q000473:pathology; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology*; D003093:Colitis, Ulcerative / Q000503:physiopathology; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000970:Antineoplastic Agents; D002945:Cisplatin