title: Distribution and antifungal susceptibility of Candida species causing candidemia from 1996 to 1999.
abstract: Susceptibilities to amphotericin B and fluconazole of 383 Candida species isolated from blood were determined. Candida albicans was the most common species (55.6%), followed by Candida parapsilosis (17.5%), Candida tropicalis (16.5%), Candida glabrata (5.2%), Candida guilliermondii (2.3%), and others (2.9%). All but three isolates, Candida ciferrii, C. tropicalis, and C. glabrata, one each, were susceptible to amphotericin B. A total of 367 (95.8%) and 15 (4.2%) isolates were susceptible and susceptible-dose dependent to fluconazole, respectively. Only one isolate, a C. glabrata, was resistant to fluconazole. Few patients (13%) having prior fluconazole treatments may explain the low rate of resistance to fluconazole in this study.
authors.affiliation: Department of Microbiology, Veterans General Hospital, Kaohsiung, Taiwan.
authors.forename: Ming-Fang
authors.initials: MF
authors.lastname: Cheng
authors.forename: Kwok-Woon
authors.initials: KW
authors.lastname: Yu
authors.forename: Ran-Bin
authors.initials: RB
authors.lastname: Tang
authors.forename: Yu-Hua
authors.initials: YH
authors.lastname: Fan
authors.forename: Yun-Liang
authors.initials: YL
authors.lastname: Yang
authors.forename: Kai-Sheng
authors.initials: KS
authors.lastname: Hsieh
authors.forename: Monto
authors.initials: M
authors.lastname: Ho
authors.forename: Hsiu-Jung
authors.initials: HJ
authors.lastname: Lo
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D002175:Candida / Q000145:classification* / Q000187:drug effects*; D002177:Candidiasis / Q000188:drug therapy; D025141:Drug Resistance, Fungal; D015725:Fluconazole / Q000494:pharmacology*; D016469:Fungemia / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D012494:Sampling Studies; D012680:Sensitivity and Specificity
chemical_list: D000666:Amphotericin B; D015725:Fluconazole