Genetic mapping using haplotype and model-free linkage analysis supports previous evidence for a locus predisposing to severe bipolar disorder at 5q31-33.
We report further evidence for our previous suggestion [Garner et al., 2001: Am J Hum Genet 68:1061-1064] of a locus on 5q predisposing to bipolar I disorder (BP-I) in an extended Costa Rican pedigree. We genotyped additional microsatellite markers in this region and applied a multi-point non-parametric linkage analysis (SimWalk2). Significant identity-by-descent allele sharing among affected relatives was observed for all of the 20 markers tested in a segment of approximately 15 cM. Most affected individuals shared a single haplotype over this region; breaks within this haplotype may suggest a more restricted candidate location for a BP-I gene. These results support the suggestion that a locus at 5q31-33, together with a previously reported locus at 18q22-23, may provide the major genetic risk for BP-I in this family.
Hong
Kyung Sue
KS
Center for Neurobehavioral Genetics, University of California Los Angeles, Los Angeles, California 90095-1761, USA.
McInnes
L Alison
LA
Service
Susan K
SK
Song
Terry
T
Lucas
Jennifer
J
Silva
Sandra
S
Fournier
Eduardo
E
León
Pedro
P
Molina
Julio
J
Reus
Victor I
VI
Sandkuijl
Lodewijk A
LA
Freimer
Nelson B
NB
D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D003364:Costa Rica; D004198:Disease Susceptibility; D005260:Female; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide / Q000235:genetics