title: Disk diffusion quality control guidelines for NVP-PDF 713: a novel peptide deformylase inhibitor.
abstract: NVP-PDF713 is a peptide deformylase inhibitor that has emerged as a candidate for treating Gram-positive infections and selected Gram-negative species that commonly cause community-acquired respiratory tract infections. This report summarizes the results of a multi-center (seven participants) disk diffusion quality control (QC) investigation for NVP PDF-713 using guidelines of the National Committee for Clinical Laboratory Standards and the standardized disk diffusion method. A total of 420 NVP-PDF 713 zone diameter values were generated for each QC organism. The proposed zone diameter ranges contained 97.6-99.8% of the reported participant results and were: Staphylococcus aureus ATCC 25923 (25-35 mm), Streptococcus pneumoniae ATCC 49619 (30-37 mm), and Haemophilus influenzae ATCC 49247 (24-32 mm). These QC criteria for the disk diffusion method should be applied during the NVP-PDF 713 clinical trials to maximize test accuracy.
authors.affiliation: The Jones Group/JMI Laboratories, North Liberty, IA, USA. tamara-anderegg@jmilabs.com
authors.forename: Tamara R
authors.initials: TR
authors.lastname: Anderegg
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Jones
mesh_terms: D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D003470:Culture Media; D004058:Diffusion; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D017408:Guidelines as Topic; D006801:Humans; D008826:Microbial Sensitivity Tests; D011786:Quality Control; D012680:Sensitivity and Specificity
chemical_list: D003470:Culture Media; D000581:Amidohydrolases; C084507:peptide deformylase