Determination of thiopurine methyltransferase activity in isolated human erythrocytes does not reflect putative in vivo enzyme inhibition by sulfasalazine.
Shipkova
Maria
M
Central Institute for Clinical Chemistry and Laboratory Medicine, Klinikum Stuttgart, Germany. m.shipkova@klinikum-stuttgart.de
Niedmann
Paul Dieter
PD
Armstrong
Victor W
VW
Oellerich
Michael
M
Wieland
Eberhard
E
D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D066298:In Vitro Techniques; D008780:Methyltransferases / Q000037:antagonists & inhibitors* / Q000097:blood* / Q000172:deficiency; D012460:Sulfasalazine / Q000009:adverse effects* / Q000627:therapeutic use
D012460:Sulfasalazine; D008780:Methyltransferases; C022745:thiopurine methyltransferase