Prognostic factors for severe acute respiratory syndrome: a clinical analysis of 165 cases.
This study analyzes single factors that affect the prognosis of severe acute respiratory syndrome (SARS) and establishes a prognosis model by multivariate analysis. We retrospectively analyzed the clinical features of SARS in 165 clinically confirmed severe cases. Both age and existence of other diseases before SARS were significantly correlated with prognosis (r=0.506 and r=0.457, respectively; P<.001). During the acute phase of SARS, lactate dehydrogenase level, degree of hypoxemia, respiratory rate, alpha -hydroxybutyric dehydrogenase level, creatine kinase isoenzyme-MB, platelet count, and number of involved lobes noted on chest radiographs, and so on, correlated markedly with the prognosis (r=0.257-0.788; P<.05). The multivariate prognosis regression model was associated with degree of hypoxemia and platelet count. The model was defined by the formula Py=1=es/(1+es), where S is [2.490 x degree of hypoxemia]-[0.050 x number of platelets], and it had a high sensitivity (91.67%), specificity (98.33%), and accuracy (96.42%). The model could be used to effectively judge the state of illness and the prognosis.
Zou
Zhengsheng
Z
Department of Infectious Diseases, Beijing Infectious Disease Institute of People's Liberation Army, Beijing, China.
Yang
Yongping
Y
Chen
Jumei
J
Xin
Shaojie
S
Zhang
Wei
W
Zhou
Xianzhi
X
Mao
Yuanli
Y
Hu
Liangping
L
Liu
Daojian
D
Chang
Binxia
B
Chang
Weihua
W
Liu
Yanping
Y
Ma
Xuemei
X
Wang
Yedong
Y
Liu
Xiqing
X
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003402:Creatine Kinase / Q000378:metabolism; D005260:Female; D006801:Humans; D006884:Hydroxybutyrate Dehydrogenase / Q000378:metabolism; D007677:Kidney Function Tests; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010976:Platelet Count; D011379:Prognosis; D012119:Respiration; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D045169:Severe Acute Respiratory Syndrome / Q000175:diagnosis* / Q000201:enzymology / Q000378:metabolism
D007770:L-Lactate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase; D003402:Creatine Kinase