title: Differential diffusions of indinavir and lopinavir in genital secretions of human immunodeficiency virus-infected women.
abstract: Plasma and cervicovaginal secretion (CVS) samples were collected from 19 human immunodeficiency virus type 1-infected women on lopinavir- or indinavir-containing regimens. Lopinavir and indinavir were detectable in 29 and 93% of CVS samples, respectively, a finding that may be ascribed to these drugs' differences in protein binding and pK(a). The relationship between lopinavir and indinavir pharmacodynamics and viral evolution in the female genital tract should be assessed over time.
authors.affiliation: Fédération de Médecine Interne, Maladies Infectieuses et Tropicales and UPRES EA 3409, Université Paris-Nord, Bobigny, France. odile.launay@cch.ap-hop-paris.fr
authors.forename: Odile
authors.initials: O
authors.lastname: Launay
authors.forename: Michel
authors.initials: M
authors.lastname: Tod
authors.forename: Kamel
authors.initials: K
authors.lastname: Louchahi
authors.forename: Linda
authors.initials: L
authors.lastname: Belarbi
authors.forename: Olivier
authors.initials: O
authors.lastname: Bouchaud
authors.forename: Nathalie
authors.initials: N
authors.lastname: Mémain
authors.forename: Olivier
authors.initials: O
authors.lastname: Petitjean
authors.forename: Michel
authors.initials: M
authors.lastname: Robineau
authors.forename: Loïc
authors.initials: L
authors.lastname: Guillevin
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000097:blood / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005836:Genitalia, Female / Q000378:metabolism*; D015658:HIV Infections / Q000378:metabolism*; D015497:HIV-1; D006801:Humans; D019469:Indinavir / Q000097:blood / Q000493:pharmacokinetics*; D061466:Lopinavir; D011485:Protein Binding; D011744:Pyrimidinones / Q000097:blood / Q000493:pharmacokinetics*; D014621:Vagina / Q000378:metabolism
chemical_list: D019380:Anti-HIV Agents; D011744:Pyrimidinones; D061466:Lopinavir; D019469:Indinavir