Validation of a chiral HPLC assay for (R)-salbutamol sulfate.
A fast, reliable and specific method for the screening, confirmation, determination and quantitation of salbutamol enantiomers was developed and validated. The described procedure includes a single robust chiral HPLC determination employing a Teicoplanin stationary phase. The method was evaluated for specificity, robustness, linearity, precision and accuracy. Under the chromatographic conditions of the method, known impurities were separated from the active principle.
Halabi
Alejandra
A
Agencia Córdoba Ciencia, Unidad CEPROCOR, Alvarez de Arenales 230, 5000 Córdoba, Argentina.
Ferrayoli
Carlos
C
Palacio
Marcela
M
Dabbene
Viviana
V
Palacios
Sara
S
D000420:Albuterol / Q000032:analysis* / Q000737:chemistry / Q000592:standards; D002851:Chromatography, High Pressure Liquid / Q000379:methods / Q000592:standards; D013237:Stereoisomerism
D000420:Albuterol