The siderophore receptor IroN, but not the high-pathogenicity island or the hemin receptor ChuA, contributes to the bacteremic step of Escherichia coli neonatal meningitis.
Using a neonatal rat meningitis model, we examined the involvement of three iron uptake systems, namely, the high-pathogenicity island, the hemin receptor ChuA, and the siderophore receptor IroN, in the pathogenesis of Escherichia coli neonatal meningitis. Only IroN appeared to play a major role during the bacteremic step of the disease.
Nègre
Valérie Lefranc
VL
Laboratoire d'Etudes de Génétique Bactérienne dans les Infections de l'Enfant (EA 3105), Université Denis Diderot-Paris 7, Service de Microbiologie, Hôpital Robert Debré (AP-HP), 75019 Paris, France.
Bonacorsi
Stéphane
S
Schubert
Soren
S
Bidet
Philippe
P
Nassif
Xavier
X
Bingen
Edouard
E
D000818:Animals; D000831:Animals, Newborn; D016470:Bacteremia / Q000209:etiology*; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000502:physiology*; D001483:Base Sequence; D004926:Escherichia coli / Q000378:metabolism / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000209:etiology*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000502:physiology*; D007501:Iron / Q000378:metabolism*; D016920:Meningitis, Bacterial / Q000209:etiology*; D008969:Molecular Sequence Data; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology*; D014774:Virulence
D001425:Bacterial Outer Membrane Proteins; C423457:ChuA protein, E coli; D029968:Escherichia coli Proteins; D011956:Receptors, Cell Surface; C035902:siderophore receptors; D007501:Iron