title: Global mapping of the yeast genetic interaction network.
abstract: A genetic interaction network containing approximately 1000 genes and approximately 4000 interactions was mapped by crossing mutations in 132 different query genes into a set of approximately 4700 viable gene yeast deletion mutants and scoring the double mutant progeny for fitness defects. Network connectivity was predictive of function because interactions often occurred among functionally related genes, and similar patterns of interactions tended to identify components of the same pathway. The genetic network exhibited dense local neighborhoods; therefore, the position of a gene on a partially mapped network is predictive of other genetic interactions. Because digenic interactions are common in yeast, similar networks may underlie the complex genetics associated with inherited phenotypes in other organisms.
authors.affiliation: Banting and Best Department of Medical Research, University of Toronto, Toronto, ON, Canada M5G 1L6.
authors.forename: Amy Hin Yan
authors.initials: AH
authors.lastname: Tong
authors.forename: Guillaume
authors.initials: G
authors.lastname: Lesage
authors.forename: Gary D
authors.initials: GD
authors.lastname: Bader
authors.forename: Huiming
authors.initials: H
authors.lastname: Ding
authors.forename: Hong
authors.initials: H
authors.lastname: Xu
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Xin
authors.forename: James
authors.initials: J
authors.lastname: Young
authors.forename: Gabriel F
authors.initials: GF
authors.lastname: Berriz
authors.forename: Renee L
authors.initials: RL
authors.lastname: Brost
authors.forename: Michael
authors.initials: M
authors.lastname: Chang
authors.forename: YiQun
authors.initials: Y
authors.lastname: Chen
authors.forename: Xin
authors.initials: X
authors.lastname: Cheng
authors.forename: Gordon
authors.initials: G
authors.lastname: Chua
authors.forename: Helena
authors.initials: H
authors.lastname: Friesen
authors.forename: Debra S
authors.initials: DS
authors.lastname: Goldberg
authors.forename: Jennifer
authors.initials: J
authors.lastname: Haynes
authors.forename: Christine
authors.initials: C
authors.lastname: Humphries
authors.forename: Grace
authors.initials: G
authors.lastname: He
authors.forename: Shamiza
authors.initials: S
authors.lastname: Hussein
authors.forename: Lizhu
authors.initials: L
authors.lastname: Ke
authors.forename: Nevan
authors.initials: N
authors.lastname: Krogan
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Li
authors.forename: Joshua N
authors.initials: JN
authors.lastname: Levinson
authors.forename: Hong
authors.initials: H
authors.lastname: Lu
authors.forename: Patrice
authors.initials: P
authors.lastname: Ménard
authors.forename: Christella
authors.initials: C
authors.lastname: Munyana
authors.forename: Ainslie B
authors.initials: AB
authors.lastname: Parsons
authors.forename: Owen
authors.initials: O
authors.lastname: Ryan
authors.forename: Raffi
authors.initials: R
authors.lastname: Tonikian
authors.forename: Tania
authors.initials: T
authors.lastname: Roberts
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Sdicu
authors.forename: Jesse
authors.initials: J
authors.lastname: Shapiro
authors.forename: Bilal
authors.initials: B
authors.lastname: Sheikh
authors.forename: Bernhard
authors.initials: B
authors.lastname: Suter
authors.forename: Sharyl L
authors.initials: SL
authors.lastname: Wong
authors.forename: Lan V
authors.initials: LV
authors.lastname: Zhang
authors.forename: Hongwei
authors.initials: H
authors.lastname: Zhu
authors.forename: Christopher G
authors.initials: CG
authors.lastname: Burd
authors.forename: Sean
authors.initials: S
authors.lastname: Munro
authors.forename: Chris
authors.initials: C
authors.lastname: Sander
authors.forename: Jasper
authors.initials: J
authors.lastname: Rine
authors.forename: Jack
authors.initials: J
authors.lastname: Greenblatt
authors.forename: Matthias
authors.initials: M
authors.lastname: Peter
authors.forename: Anthony
authors.initials: A
authors.lastname: Bretscher
authors.forename: Graham
authors.initials: G
authors.lastname: Bell
authors.forename: Frederick P
authors.initials: FP
authors.lastname: Roth
authors.forename: Grant W
authors.initials: GW
authors.lastname: Brown
authors.forename: Brenda
authors.initials: B
authors.lastname: Andrews
authors.forename: Howard
authors.initials: H
authors.lastname: Bussey
authors.forename: Charles
authors.initials: C
authors.lastname: Boone
mesh_terms: D000595:Amino Acid Sequence; D019295:Computational Biology; D003550:Cystic Fibrosis / Q000235:genetics; D017353:Gene Deletion; D020043:Genes, Essential; D005800:Genes, Fungal; D030342:Genetic Diseases, Inborn / Q000235:genetics; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D020412:Multifactorial Inheritance; D009154:Mutation; D010641:Phenotype; D011110:Polymorphism, Genetic; D012174:Retinitis Pigmentosa / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D029701:Saccharomyces cerevisiae Proteins