title: Influence of intracranial hemorrhage and neonatal seizures on the neurological and psychomotor development of premature infants at Hospital de Clínicas de Porto Alegre, Brazil.
abstract: This study compared the results of neurodevelopmental examination at 6 months' corrected age of premature infants with neonatal seizures and/or intracranial hemorrhage and normal premature infants. There was a statistically significant correlation (p=0.000007) between intracranial hemorrhage and seizures in the group of 68 premature infants seen in the neurodevelopmental outpatient service at Hospital de Clínicas de Porto Alegre, Brazil. Intracranial hemorrhage was significantly associated with multiparity (p=0.02). The neurodevelopmental examination at 6 months' corrected age revealed that patients who suffered neonatal intracranial hemorrhage and/or seizures had inappropriate muscle tone, strength and reflexes, as well as delay in head control.
  
  
  CONCLUSIONS
  We compared the results of neurodevelopmental examinations of two groups of premature infants at 6 months' corrected age. The difference in neurological development at 6 months' corrected age was statistically significant when comparison was corrected for premature infants who had neonatal seizures and periventricular hemorrhage.
authors.affiliation: Pediatric Neurologist, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil. fp54@terra.com.br
authors.forename: Lygia
authors.initials: L
authors.lastname: Ohlweiler
authors.forename: Alexandre Rodrigues
authors.initials: AR
authors.lastname: da Silva
authors.forename: Sonja Vergínia
authors.initials: SV
authors.lastname: Barros
authors.forename: Rudimar
authors.initials: R
authors.lastname: Riesgo
authors.forename: Newra Tellechea
authors.initials: NT
authors.lastname: Rotta
mesh_terms: D001938:Brazil; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D020300:Intracranial Hemorrhages / Q000150:complications / Q000503:physiopathology*; D008297:Male; D009460:Neurologic Examination; D010298:Parity; D011596:Psychomotor Disorders / Q000175:diagnosis; D011597:Psychomotor Performance / Q000502:physiology*; D012640:Seizures / Q000150:complications / Q000503:physiopathology*