Acremonidins, new polyketide-derived antibiotics produced by Acremonium sp., LL-Cyan 416.
Acremonidins A to approximately E (1 to approximately 5) were produced by fermentation of Acremonium sp., LL-Cyan 416, in heterogeneous phases. The structures of these compounds, containing a bridging keto group, were determined by spectroscopic analysis. Acremonidins A and B showed moderate activity against Gram-positive bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci. Selective acylations of acremonidin B afforded ester derivatives 6 to approximately 9 that exhibited improved antibacterial activity.
He
Haiyin
H
Natural Products Research, Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, NY 10965, USA. heh@wyeth.com
Bigelis
Ramunas
R
Solum
Eric H
EH
Greenstein
Michael
M
Carter
Guy T
GT
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents