title: A new approach to stereospecific synthesis of P-chiral phosphorothioates. Preparation of diastereomeric dithymidyl-(3'-5') phosphorothioates.
abstract: A new method for stereospecific synthesis of P-chiral phosphorothioates based on intramolecular nucleophile catalysis was developed.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91 Stockholm, Sweden.
authors.forename: Helena
authors.initials: H
authors.lastname: Almer
authors.forename: Tomas
authors.initials: T
authors.lastname: Szabo
authors.forename: Jacek
authors.initials: J
authors.lastname: Stawinski
mesh_terms: D002384:Catalysis; D015394:Molecular Structure; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013873:Thionucleotides / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D016376:Oligonucleotides, Antisense; D013873:Thionucleotides