title: Unusual presentation of life-threatening Toscana virus meningoencephalitis.
abstract: This case report describes a brother and a sister with severe meningoencephalitis caused by Toscana virus (TOSv). The clinical presentation was characterized by stiff neck, deep coma, maculopapular rash, diffuse lymphadenopathy, hepatosplenomegaly, renal involvement, tendency to bleeding, and diffuse intravascular coagulation. The boy had epididymo-orchitis. Recovery with neurologic sequelae as hydrocephalus was observed. Microbiological diagnosis was obtained by serological tests and reverse transcriptase-polymerase chain reaction. Sequencing of polymerase chain reaction products from the S and M segments was carried out. TOSv may be a causative agent in severe meningoencephalitis.
authors.affiliation: Clinica di Malattie Infettive, Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Universita degli Studi di Perugia, Perugia, Italy. rprof2f1@unipg.it
authors.forename: Franco
authors.initials: F
authors.lastname: Baldelli
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Ciufolini
authors.forename: Daniela
authors.initials: D
authors.lastname: Francisci
authors.forename: Antonella
authors.initials: A
authors.lastname: Marchi
authors.forename: Giulietta
authors.initials: G
authors.lastname: Venturi
authors.forename: Cristiano
authors.initials: C
authors.lastname: Fiorentini
authors.forename: Maria Laura
authors.initials: ML
authors.lastname: Luchetta
authors.forename: Lidia
authors.initials: L
authors.lastname: Bruto
authors.forename: Sergio
authors.initials: S
authors.lastname: Pauluzzi
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000503:physiopathology* / Q000821:virology; D010217:Phlebotomus Fever / Q000503:physiopathology* / Q000821:virology; D012367:RNA, Viral / Q000032:analysis; D029301:Sandfly fever Naples virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D012698:Serologic Tests
chemical_list: D012367:RNA, Viral