title: Effects of nitric oxide on proprioceptive signaling.
abstract: We have analysed the effects of the neuromodulator nitric oxide (NO) on proprioceptive information processing by ascending intersegmental interneurons that form part of the local circuits within the terminal abdominal ganglion of the crayfish. NO modulates the synaptic inputs to ascending interneurons, enhancing the amplitude of class I interneurons and reducing the amplitude of class II interneurons. Repetitive proprioceptive stimulation leads to rapid depression in a specific set of identified interneurons but not in others. Bath application of a nitric oxide scavenger, PTIO, causes a significant decrease in the rate of depression of the interneurons showing a rapid depression, independent of interneuron class, but has no effect on the dynamic responses of the interneurons that show little initial depression. These results indicate that NO exerts multiple effects at the very first stage of synaptic integration in local circuits.
authors.affiliation: School of Biological Sciences, University of Southampton, UK.
authors.forename: Hansjügen
authors.initials: H
authors.lastname: Schuppe
authors.forename: Makoto
authors.initials: M
authors.lastname: Araki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Aonuma
authors.forename: Toshiki
authors.initials: T
authors.lastname: Nagayama
authors.forename: Philip L
authors.initials: PL
authors.lastname: Newland
mesh_terms: D000818:Animals; D003400:Astacoidea / Q000378:metabolism*; D004594:Electrophysiology; D017952:Ganglia, Invertebrate / Q000378:metabolism*; D007395:Interneurons / Q000378:metabolism*; D009569:Nitric Oxide / Q000502:physiology*; D011434:Proprioception; D009435:Synaptic Transmission
chemical_list: D009569:Nitric Oxide