[Effect of 6-hydroxydopamine on the electrical characteristics of snail neurons in long-term sensitization].
Studies of the influence of neurotoxin 6-hydroxydopamine selectively destroying the catecholamine terminals on long-term sensitization, and the role of dopamine in manifestation of characteristics of a membrane of identified neurons during elaboration of plasticity, were fulfilled. Injection of saline was used as the control. It is shown that preliminary injection of 6-hydroxydopamine reduces duration of long-term sensitization, but does not block it completely. It was shown that injection of 6-hydroxydopamine prevents diminishing of membrane and threshold potentials in withdrawal interneurons during formation of long-term sensitization. The experiments demonstrate that shift of electrical characteristics of withdrawal interneurons caused by injection of neurotoxin 6-hydroxydopamine to both naive snails and sensitized snails, statys during at least 10 days.
Andrianov
V V
VV
Kazan Physical-Technical Institute, Russian Acad. Sci., 420029, Kazan-29, 10/7 Sibirsky Trakt.
Tagirova
R R
RR
Gaĭnutdinov
Kh L
KhL
Gaĭnudinova
T Kh
TKh
Golubev
A I
AI
Muranova
L N
LN
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006372:Helix, Snails / Q000187:drug effects* / Q000502:physiology; D017774:Long-Term Potentiation; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D009498:Neurotoxins / Q000494:pharmacology*; D016627:Oxidopamine / Q000494:pharmacology*; D013997:Time Factors
D009498:Neurotoxins; D016627:Oxidopamine