Increased FAT (fatty acid translocase)/CD36-mediated long-chain fatty acid uptake in cardiac myocytes from obese Zucker rats.
Disturbed cardiac lipid homoeostasis in obesity is regarded as a key player in the development of cardiovascular diseases. In this study, we show that FAT (fatty acid translocase)/CD36-mediated LCFA (long-chain fatty acid) uptake in cardiac myocytes from young adult obese Zucker rats is markedly increased, but insensitive to insulin. Basal and insulin-induced glucose uptake rates in these myocytes are not changed, suggesting that during the development from obesity to hyperglycaemic Type II diabetes, alterations in cardiac LCFA uptake precede alterations in cardiac glucose uptake.
Coort
S L M
SL
Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, Maastricht University, P.O. Box 616, NL-6200 MD Maastricht, The Netherlands. S.Coort@gen.unimaas.nl
Luiken
J J F P
JJ
van der Vusse
G J
GJ
Bonen
A
A
Glatz
J F C
JF
D000818:Animals; D018955:CD36 Antigens / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D007328:Insulin / Q000494:pharmacology; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D027361:Organic Anion Transporters / Q000378:metabolism*; D051381:Rats; D011924:Rats, Zucker; D012508:Sarcolemma / Q000378:metabolism
D018955:CD36 Antigens; D005227:Fatty Acids; D007328:Insulin; D027361:Organic Anion Transporters