Role of Na+-Ca2+ exchanger in myocardial ischemia/reperfusion injury: evaluation using a heterozygous Na+-Ca2+ exchanger knockout mouse model.
We used Na(+)-Ca(2+) exchanger (NCX) knockout mice to evaluate the effects of NCX in cardiac function and the infarct size after ischemia/reperfusion injury. The contractile function in NCX KO mice hearts was significantly better than that in wild type (WT) mice hearts after ischemia/reperfusion and the infarct size was significantly small in NCX KO mice hearts compared with that in WT mice hearts. NCX is critically involved in the development of ischemia/reperfusion-induced myocardial injury and therefore the inhibition of NCX function may contribute to cardioprotection against ischemia/reperfusion injury.
Ohtsuka
Masashi
M
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan.
Takano
Hiroyuki
H
Suzuki
Masashi
M
Zou
Yunzeng
Y
Akazawa
Hiroshi
H
Tamagawa
Masaji
M
Wakimoto
Koji
K
Nakaya
Haruaki
H
Komuro
Issei
I
D000818:Animals; D002118:Calcium / Q000737:chemistry / Q000378:metabolism; D004195:Disease Models, Animal; D006321:Heart / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D006579:Heterozygote; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009203:Myocardial Infarction / Q000378:metabolism; D017202:Myocardial Ischemia / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000378:metabolism* / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D032383:Myocytes, Cardiac / Q000502:physiology; D019831:Sodium-Calcium Exchanger / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D013194:Staining and Labeling / Q000379:methods; D013778:Tetrazolium Salts / Q000737:chemistry
D019831:Sodium-Calcium Exchanger; D013778:Tetrazolium Salts; D002118:Calcium