Comparison of the [13C]glucose breath test to the hyperinsulinemic-euglycemic clamp when determining insulin resistance.
OBJECTIVE
With increasing emphasis on the recognition of the metabolic syndrome and early type 2 diabetes, a clinically useful measure of insulin resistance is desirable. The purpose of this study was to evaluate whether an index of glucose metabolism, as measured by (13)CO(2) generation from ingested [(13)C]glucose, would correlate with indexes from the hyperinsulinemic-euglycemic clamp.


METHODS
A total of 26 subjects with varying degrees of insulin sensitivity underwent both the [(13)C]glucose breath test and the hyperinsulinemic-euglycemic clamp. Results from the [(13)C]glucose breath test were compared with measures of insulin sensitivity from the glucose clamp as well as with other commonly used indexes of insulin sensitivity.


RESULTS
There was a strong correlation between the [(13)C]glucose breath test result and the glucose disposal rate (r = 0.69, P < 0.0001) and insulin sensitivity index (r = 0.69, P < 0.0001) from the insulin clamp. The magnitude of these correlations compared favorably with QUICKI and were superior to the homeostasis model assessment.


CONCLUSIONS
The [(13)C]glucose breath test may provide a useful noninvasive assessment of insulin sensitivity.
Lewanczuk
Richard Z
RZ
Division of Endocrinology, University of Alberta, Edmonton, Canada. rlewancz@gpu.srv.ualberta.ca
Paty
Breay W
BW
Toth
Ellen L
EL
D000328:Adult; D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism*; D001944:Breath Tests / Q000379:methods*; D002247:Carbon Isotopes; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D005947:Glucose / Q000032:analysis*; D015309:Glucose Clamp Technique; D006801:Humans; D006946:Hyperinsulinism; D007333:Insulin Resistance / Q000502:physiology*; D012016:Reference Values; D012044:Regression Analysis; D015203:Reproducibility of Results
D001786:Blood Glucose; D002247:Carbon Isotopes; D005947:Glucose