First carbamates conversion to amides by simple alkyl group transfer from trialkylalanes.
[reaction: see text] N-Monosubstituted carbamates are cleanly converted to amides under treatment with trialkylaluminum. This reaction involves an aluminum-assisted internal delivery of alkyl groups. It can be applied to new and mild protecting group strategies for alcohols.
El Kaim
Laurent
L
Laboratoire Chimie et procédés, Ecole Nationale Supérieure de Techniques Avancées, 32 Bd Victor, 75739 Paris Cedex 15, France. elkaim@ensta.fr
Grimaud
Laurence
L
Lee
Anabelle
A
Perroux
Yannick
Y
Tirla
Cornelia
C