title: Primary pelvic telangiectatic osteosarcoma metastatic to both orbits.
abstract: We report a case of a 23-year-old man with primary pelvic telangiectatic osteosarcoma metastatic to both orbits. The patient had proptosis with optic neuropathies and intermittent third nerve palsies. His disease was unresponsive to chemotherapy or radiotherapy, and extensive craniofacial involvement precluded surgical resection. The patient died of his disease. Telangiectatic osteosarcoma, a rare variant of osteosarcoma that is distinguished by blood-filled cystic spaces, may metastasize to the orbit and skull base. Because telangiectatic osteosarcoma may radiographically resemble other benign and malignant lesions, biopsy is essential for accurate diagnosis that will ultimately dictate clinical therapy. However, patients with this disease have a poor prognosis.
authors.affiliation: Department of Ophthalmology, University of Tennessee Health Science Center, Memphis, Tennessee, U.S.A.
authors.forename: Yasaman
authors.initials: Y
authors.lastname: Mohadjer
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Wilson
authors.forename: Christine E
authors.initials: CE
authors.lastname: Fuller
authors.forename: Barrett G
authors.initials: BG
authors.lastname: Haik
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology*; D005094:Exophthalmos / Q000209:etiology; D017809:Fatal Outcome; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D015840:Oculomotor Nerve Diseases / Q000209:etiology; D009901:Optic Nerve Diseases / Q000209:etiology; D009918:Orbital Neoplasms / Q000556:secondary*; D012516:Osteosarcoma / Q000556:secondary*; D010388:Pelvis; D014057:Tomography, X-Ray Computed