title: Oxidative coupling of epigallocatechin gallate amplifies antioxidant activity and inhibits xanthine oxidase activity.
abstract: Oxidative coupling of epigallocatechin gallate resulted in great improvement in antioxidant activity such as radical scavenging activity against superoxide anion and in activity to inhibit xanthine oxidase, offering high potential as a therapeutic agent for prevention of xanthine oxidase-induced diseases such as gout.
authors.affiliation: Bio-oriented Technology Research Advancement Institution, and Department of Materials Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
authors.forename: Motoichi
authors.initials: M
authors.lastname: Kurisawa
authors.forename: Joo Eun
authors.initials: JE
authors.lastname: Chung
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uyama
authors.forename: Shiro
authors.initials: S
authors.lastname: Kobayashi
mesh_terms: D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010084:Oxidation-Reduction / Q000187:drug effects; D013481:Superoxides / Q000737:chemistry / Q000378:metabolism; D019820:Xanthine / Q000737:chemistry / Q000378:metabolism; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D013481:Superoxides; D019820:Xanthine; D002392:Catechin; C045651:epigallocatechin gallate; D014969:Xanthine Oxidase