The wide pharmacological versatility of semicarbazones, thiosemicarba-zones and their metal complexes.
The more significant bioactivities of a variety of semicarbazones (anti-protozoa, anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and their metal complexes are reviewed together with proposed mechanisms of action and structure-activity relationships. Clinical or potential pharmacological applications of these versatile compounds are discussed.
Beraldo
Heloisa
H
Departamento de Química, Universidade Federal de Minas Gerais, 31270-901, Belo Horizonte, MG, Brazil. beraldo@dedalus.lcc.ufmg.br
Gambino
Dinorah
D
D000890:Anti-Infective Agents / Q000494:pharmacology; D000927:Anticonvulsants / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D009942:Organometallic Compounds / Q000494:pharmacology*; D019275:Radiopharmaceuticals; D012664:Semicarbazones / Q000819:agonists / Q000494:pharmacology*; D013882:Thiosemicarbazones / Q000819:agonists / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000927:Anticonvulsants; D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D019275:Radiopharmaceuticals; D012664:Semicarbazones; D013882:Thiosemicarbazones