title: Reticulon3 expression in rat optic and olfactory systems.
abstract: Reticulon3 (RTN3), which belongs to a reticulon family, is first isolated from the retina, but little is known about its function. We investigated the distribution of RTN3 in rat retina and olfactory bulb by immunohistochemistry. In the retina, Müller cells highly expressed RTN3. The expression level of RTN3 in the optic nerve was high in the embryo, but low in the adult. In the olfactory system, RTN3 was highly expressed in the olfactory nerve both in developmental and adult stages. Further, RTN3 was co-localized with synaptophysin in tubulovesicular structures in the developing axon of cultured cortical neurons. These results suggest that RTN3 may play an important role in the developing axons and also in some glial cells such as Müller cells.
authors.affiliation: Department of Pharmacology, Osaka University Medical School, Suita, Osaka 565-0871, Japan.
authors.forename: Emi
authors.initials: E
authors.lastname: Kumamaru
authors.forename: Che-Hui
authors.initials: CH
authors.lastname: Kuo
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujimoto
authors.forename: Keiko
authors.initials: K
authors.lastname: Kohama
authors.forename: Ling-Hui
authors.initials: LH
authors.lastname: Zeng
authors.forename: Eiichi
authors.initials: E
authors.lastname: Taira
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Tanaka
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Toyoda
authors.forename: Naomasa
authors.initials: N
authors.lastname: Miki
mesh_terms: D000818:Animals; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D007150:Immunohistochemistry; D051379:Mice; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics; D009830:Olfactory Bulb / Q000737:chemistry / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012160:Retina / Q000737:chemistry / Q000378:metabolism*
chemical_list: D009419:Nerve Tissue Proteins; C489914:Rtn1 protein, mouse; C489913:Rtn1 protein, rat