title: Focal brain edema and natriuretic peptides in patients with subarachnoid hemorrhage.
abstract: Central salt wasting syndrome may be caused by pathological increases in serum natriuretic peptides after subarachnoid hemorrhage (SAH). However, it is unclear as to why the serum concentration of atrial natriuretic peptide (ANP) or brain natriuretic peptide (BNP) increases in the subacute phase of SAH. The present study was designed to assess the correlation between focal brain edema and serum concentration of ANP or BNP in patients with SAH. Focal brain edema was found in 8 SAH-patients and peaked between days 4 and 7 of SAH. The mean serum ANP and BNP levels in patients with focal brain edema were significantly higher than those in patients without focal brain edema between days 4 and 14 of SAH. These results suggest that focal brain edema might correlate with increased levels of ANP and BNP in the subacute phase of SAH.
authors.affiliation: Department of Neurosurgery, National Defense Medical College, Tokorozawa, Saitama, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Fukui
authors.forename: H
authors.initials: H
authors.lastname: Nawashiro
authors.forename: N
authors.initials: N
authors.lastname: Otani
authors.forename: H
authors.initials: H
authors.lastname: Ooigawa
authors.forename: T
authors.initials: T
authors.lastname: Toyooka
authors.forename: N
authors.initials: N
authors.lastname: Tsuzuki
authors.forename: H
authors.initials: H
authors.lastname: Katoh
authors.forename: S
authors.initials: S
authors.lastname: Ishihara
authors.forename: T
authors.initials: T
authors.lastname: Miyazawa
authors.forename: A
authors.initials: A
authors.lastname: Ohnuki
authors.forename: K
authors.initials: K
authors.lastname: Shima
mesh_terms: D009320:Atrial Natriuretic Factor / Q000097:blood*; D001929:Brain Edema / Q000097:blood* / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D012189:Retrospective Studies; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000150:complications* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014667:Vasopressins / Q000097:blood
chemical_list: D014667:Vasopressins; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor