The chalcone butein from Rhus verniciflua shows antifibrogenic activity.
Butein is known to be the major component of the bark of Rhus verniciflua Stokes (Anacardiaceae). The aim of this work was to investigate the effects of butein on liver fibrosis induced by carbon tetrachloride (CCl4) in rats, and to explore its antifibrogenic mechanism. Butein (10 mg/kg/day or 25 mg/kg/day) showed a significant reduction of hydroxyproline and malondialdehyde levels in rats. The expression of alpha1(I) collagen and tissue inhibitor of metalloproteinase-1 (TIMP-1) mRNAs in liver was clearly reduced in a dose-dependent manner in rats given butein compared with control CCl4-treated rats. These data suggest the potential of butein to serve as an antifibrogenic agent by inhibition of collagen accumulation and lipid peroxidation, and by down-regulation of the expression of both alpha1(I) collagen and TIMP-1 mRNA.
Lee
Sung Hee
SH
College of Pharmacy, Medicinal Resources Research Center, Wonkwang University, Iksan, Chonbuk, Republic of Korea.
Nan
Ji-Xing
JX
Zhao
Yu Zhe
YZ
Woo
Sun Wook
SW
Park
Eun-Jeon
EJ
Kang
Tai-Hyun
TH
Seo
Geom Seog
GS
Kim
Youn-Chul
YC
Sohn
Dong Hwan
DH
D000818:Animals; D002251:Carbon Tetrachloride; D002599:Chalcone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D047188:Chalcones; D024042:Collagen Type I / Q000235:genetics; D017931:DNA Primers; D004305:Dose-Response Relationship, Drug; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D020011:Protective Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction; D029045:Rhus; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000235:genetics
D047188:Chalcones; D024042:Collagen Type I; D017931:DNA Primers; D010936:Plant Extracts; D020011:Protective Agents; D012333:RNA, Messenger; D019715:Tissue Inhibitor of Metalloproteinase-1; C040918:butein; D002599:Chalcone; D002251:Carbon Tetrachloride