title: Conservation of protein-protein interactions - lessons from ascomycota.
abstract: Interacting proteins from Saccharomyces cerevisiae are evolutionarily conserved and their likelihood of having an ortholog in other ascomycota species correlates with the number of interaction partners. Moreover, interacting proteins show a clear preference to be conserved as a pair, indicating that nature maintains selection pressure on the interaction links between proteins. The conservation of interacting protein pairs between different organisms does not exhibit any bias with respect to protein functional roles.
authors.affiliation: Institute for Bioinformatics, GSF - National Research Center for Environment and Health, Ingolstädter Landstrasse 1, Neuherberg 85764, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Pagel
authors.forename: Hans Werner
authors.initials: HW
authors.lastname: Mewes
authors.forename: Dmitrij
authors.initials: D
authors.lastname: Frishman
mesh_terms: D001665:Binding Sites; D019295:Computational Biology / Q000379:methods; D015966:Gene Expression Regulation, Fungal / Q000235:genetics*; D011485:Protein Binding; D025941:Protein Interaction Mapping; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics*
chemical_list: D029701:Saccharomyces cerevisiae Proteins