Brain tissue water uptake after middle cerebral artery occlusion assessed with CT.
OBJECTIVE
To study whether computed tomography (CT) can measure the water content of early ischemic edema.


METHODS
The authors obtained cranial CT in 5 groups of rats subjected to 1 hour (n = 8), 2 hours (n = 11), 3 hours (n = 13), 4 hours (n = 13), or 6 hours (n = 14) of right middle cerebral artery (MCA) occlusion. Immediately after CT, the authors removed the rats' brains and determined tissue water content by the dry-wet weight method. They correlated brain x-ray attenuation with brain tissue water content.


RESULTS
Mean brain tissue water content remained constant in the nonischemic left hemispheres at 77.9% +/- 0.6% and increased up to 79.3% +/- 1.0% in the right hemispheres after 6 hours of permanent right MCA occlusion. X-ray attenuation remained constant in the left hemispheres at 75.6 + 2.2 Hounsfield units (HU) and decreased to 71.7 +/- 3.4 HU in the right hemispheres after 6 hours of right MCA occlusion. The decrease in x-ray attenuation correlated significantly with the increase in ischemic brain tissue water content (y = 217.3 - 1.8x x; r = .55, P < .0001). That means that a 1% increase in hemispheric tissue water content causes a decrease in x-ray attenuation of 1.8 HU.


CONCLUSIONS
After MCA occlusion, immediate brain tissue net water uptake is associated with a decrease in x-ray attenuation. CT can monitor ischemic edema in an acute stroke.
Dzialowski
Imanuel
I
Department of Neuroradiology, University of Dresden, Dresden, Germany.
Weber
Johannes
J
Doerfler
Arnd
A
Forsting
Michael
M
von Kummer
Rüdiger
R
D000818:Animals; D001834:Body Water / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002545:Brain Ischemia / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism; D020244:Infarction, Middle Cerebral Artery / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014057:Tomography, X-Ray Computed