[HDL-cholesterol-- active or passive participant in the pathogenesis of atherosclerosis].
It is known that high sanguin levels of cholesterol and LDL-cholesterol (LDLc) have an important role in the pathogenesis of atherosclerosis. The treatment of hypercholesterolemia with statins and/or with fibrates have had beneficial effects on coronary heart disease and on other localization of atherosclerosis. The decreased of cholesterol and LDL-cholesterol is the most important effect of this treatment. The epidemiological studies have revealed that the treatment with statins and/or with fibrates produce an increase of HDL-cholesterol (HDLc), which is also very important in the regression of atherosclerosis. We tried in this review to explain the mechanisms of the increase of HDL-cholesterol, in concordance with the data from literature.
Artenie
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Clinica a III-a Medicală Cardiologică I. Enescu, Spitalul Clinic Judeţean de Urgenţe Sf. Spiridon Iaşi.
Ungureanu
Didona
D
Artenie
Anca
A
Botnariu
Gina
G
Anisie
Ecaterina
E
D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood* / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D008297:Male; D012307:Risk Factors
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002784:Cholesterol