title: Using an electrocautery strategy or recombinant follicle stimulating hormone to induce ovulation in polycystic ovary syndrome: randomised controlled trial.
abstract: OBJECTIVE
  To compare the effectiveness of an electrocautery strategy with ovulation induction using recombinant follicle stimulating hormone in patients with polycystic ovary syndrome.
  
  
  METHODS
  Randomised controlled trial.
  
  
  METHODS
  Secondary and tertiary hospitals in the Netherlands.
  
  
  METHODS
  168 patients with clomiphene citrate resistant polycystic ovary syndrome: 83 were allocated electrocautery and 85 were allocated recombinant follicle stimulating hormone.
  
  
  METHODS
  Laparoscopic electrocautery of the ovaries followed by clomiphene citrate and recombinant follicle stimulating hormone if anovulation persisted, or induction of ovulation with recombinant follicle stimulating hormone.
  
  
  METHODS
  Ongoing pregnancy within 12 months.
  
  
  RESULTS
  . The cumulative rate of ongoing pregnancy after recombinant follicle stimulating hormone was 67%. With only electrocautery it was 34%, which increased to 49% after clomiphene citrate was given. Subsequent recombinant follicle stimulating hormone increased the rate to 67% at 12 months (rate ratio 1.01, 95% confidence interval 0.81 to 1.24). No complications occurred from electrocautery with or without clomiphene citrate. Patients allocated to electrocautery had a significantly lower risk of multiple pregnancy (0.11, 0.01 to 0.86).
  
  
  CONCLUSIONS
  The ongoing pregnancy rate from ovulation induction with laparoscopic electrocautery followed by clomiphene citrate and recombinant follicle stimulating hormone if anovulation persisted, or recombinant follicle stimulating hormone, seems equivalent to ovulation induction with recombinant follicle stimulating hormone, but the former procedure carries a lower risk of multiple pregnancy.
authors.affiliation: Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology, Academic Medical Centre, PO Box 22700, 1100 DE, Amsterdam, Netherlands. n.bayram@amc.uva.nl
authors.forename: Neriman
authors.initials: N
authors.lastname: Bayram
authors.forename: Madelon
authors.initials: M
authors.lastname: van Wely
authors.forename: Eugenie M
authors.initials: EM
authors.lastname: Kaaijk
authors.forename: Patrick M M
authors.initials: PM
authors.lastname: Bossuyt
authors.forename: Fulco
authors.initials: F
authors.lastname: van der Veen
mesh_terms: D000328:Adult; D000858:Anovulation / Q000628:therapy; D002908:Chronic Disease; D004564:Electrocoagulation / Q000379:methods*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D006801:Humans; D010535:Laparoscopy; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000628:therapy*; D011247:Pregnancy / Q000706:statistics & numerical data*; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D005640:Follicle Stimulating Hormone