title: Stature of young people with malignant bone tumors.
abstract: BACKGROUND
  Little is known about the aetiology of primary bone tumours. There have been conflicting reports relating to stature in young people with bone cancer.
  
  
  METHODS
  We analysed height data at diagnosis for 364 patients with osteosarcoma and 356 patients with Ewing sarcoma registered on clinical trials run by the Medical Research Council (MRC) and the United Kingdom Children's Cancer Study Group (UKCCSG).
  
  
  METHODS
  Height at diagnosis for each patient was standardised for age and sex compared to national reference data with a standard deviation score (SDS) calculated for each subject.
  
  
  RESULTS
  Those with osteosarcoma were significantly taller than the general population (mean height SDS 0.2, P=0.001). Patients with osteosarcoma of the femur were significantly taller than patients with other primary sites (mean height SDS 0.45 vs. -0.06, P=0.0001). Overall those with Ewing sarcoma were not significantly taller than the general population (mean height SDS 0.09, P=0.1), but children presenting under 15 years were taller (SDS 0.2, P=0.004) whilst older patients were not (SDS -0.07, P=0.4). In both osteosarcoma and Ewing sarcoma the mean age at diagnosis for females was significantly younger than for males.
  
  
  CONCLUSIONS
  This study suggests that tall stature and an earlier pubertal growth spurt may be important factors in the aetiology of both osteosarcoma and Ewing sarcoma.
authors.affiliation: Department of Child Health, University of Newcastle upon Tyne, UK.
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Cotterill
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Wright
authors.forename: Mark S
authors.initials: MS
authors.lastname: Pearce
authors.forename: Alan W
authors.initials: AW
authors.lastname: Craft
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D001827:Body Height; D001859:Bone Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012516:Osteosarcoma / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D011627:Puberty / Q000502:physiology; D012512:Sarcoma, Ewing / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D017678:Sex Distribution