title: Quantitative trait loci mapping for dairy cattle production traits using a maximum likelihood method.
abstract: A maximum likelihood method was developed for QTL mapping in half-sib designs and compared to the regression method in analyses of both field and simulated data. The field data consisted of milk production evaluations of 433 progeny tested sons of 6 sires and 64 microsatellite markers distributed over 12 chromosomes. Based on permutation tests, 5 significant QTL were detected in the field data by the regression method compared with 10 by the maximum likelihood method (P < 0.05). In field data analysis, the maximum likelihood method detected more significant QTL and had a smaller residual variance than the regression method. The simulation included 9 scenarios differing in number of families, family size, QTL variance, and marker density, each replicated 100 times. The simulation results suggested that, as for the regression method, the precision of estimating QTL from the maximum likelihood method improves with increasing number of sons per sire, increasing the ratio of QTL to phenotypic variance, and decreasing marker interval. The maximum likelihood method had a smaller dispersion of estimated QTL positions than the regression method in 6 of 9 scenarios simulated. Overall, the maximum likelihood method shows potential advantage in QTL detection over the regression method, especially in the situations with less favorable conditions for QTL detection.
authors.affiliation: CGIL, Department of Animal & Poultry Science, University of Guelph, Ontario, Canada N1G 2W1. yuefu@ccsi.ca
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: G B
authors.initials: GB
authors.lastname: Jansen
authors.forename: C Y
authors.initials: CY
authors.lastname: Lin
mesh_terms: D000465:Algorithms; D000818:Animals; D001947:Breeding; D002417:Cattle / Q000235:genetics*; D005260:Female; D007774:Lactation / Q000235:genetics*; D016013:Likelihood Functions; D008297:Male; D015233:Models, Statistical; D010641:Phenotype; D040641:Quantitative Trait Loci / Q000235:genetics*; D012044:Regression Analysis; D012680:Sensitivity and Specificity