title: Parkinsonism in Ontario: comorbidity associated with hospitalization in a large cohort.
abstract: To study comorbidity in patients with Parkinsonism (PKM), relative hospitalization rates from 1994 to 1999 for 15,304 cases were compared with 30,608 controls. After correction for differential survival, the rates were higher for cases compared to controls for aspiration pneumonia (6.34; 95% confidence interval [CI], 5.23, 7.93), affective psychosis (2.71; 95% CI, 2.13, 3.32), hip fractures (2.56; 95% CI, 2.35, 2.76), other urinary tract disorders including infections (2.5; 95% CI, 2.17, 2.86), septicemia (2.39; 95% CI, 2.02, 2.85) and fluid and electrolyte disorders (2.27; 95% CI, 1.93,2.66). The rates for cardiac, cerebrovascular, and peripheral vascular disease were similar. Preventive measures and aggressive management of these conditions as outpatients may reduce the rates of hospitalization and improve the morbidity and mortality of PKM.
authors.affiliation: Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada. mguttman@movementdisorders.ca
authors.forename: Mark
authors.initials: M
authors.lastname: Guttman
authors.forename: Pamela M
authors.initials: PM
authors.lastname: Slaughter
authors.forename: Marc-Erick
authors.initials: ME
authors.lastname: Theriault
authors.forename: Donald P
authors.initials: DP
authors.lastname: DeBoer
authors.forename: C David
authors.initials: CD
authors.lastname: Naylor
mesh_terms: D000328:Adult; D000368:Aged; D002423:Cause of Death; D015331:Cohort Studies; D015897:Comorbidity; D003627:Data Interpretation, Statistical; D003953:Diagnosis-Related Groups / Q000706:statistics & numerical data*; D005260:Female; D005265:Femoral Neck Fractures / Q000175:diagnosis / Q000401:mortality; D006751:Hospital Information Systems / Q000706:statistics & numerical data; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D038801:International Classification of Diseases / Q000706:statistics & numerical data; D008297:Male; D008432:Mathematical Computing; D008875:Middle Aged; D009864:Ontario / Q000453:epidemiology; D020734:Parkinsonian Disorders / Q000175:diagnosis / Q000401:mortality*; D011015:Pneumonia, Aspiration / Q000175:diagnosis / Q000401:mortality; D011618:Psychotic Disorders / Q000175:diagnosis / Q000401:mortality; D012016:Reference Values; D018805:Sepsis / Q000175:diagnosis / Q000401:mortality; D016019:Survival Analysis; D014570:Urologic Diseases / Q000175:diagnosis / Q000401:mortality; D014600:Utilization Review / Q000706:statistics & numerical data; D014883:Water-Electrolyte Imbalance / Q000175:diagnosis / Q000401:mortality