Long-term vitamin C supplementation has no markedly favourable effect on serum lipids in middle-aged Japanese subjects.
Antioxidant vitamins have been reported to be associated with an improvement in blood lipid profiles, but results are not consistent. The present study was designed to determine whether long-term vitamin C supplementation could alter serum lipid concentrations in subjects who completed a 5-year population-based double-blind intervention trial. A total of 439 Japanese subjects with atrophic gastritis initially participated in the trial using vitamin C and beta-carotene to prevent gastric cancer. Before and upon early termination of beta-carotene supplementation, 134 subjects dropped out of the trial; finally, 161 subjects assigned to the high-dose group (500 mg vitamin C/d) and 144 subjects assigned to the low-dose group (50 mg vitamin C/d) were studied. No favourable effect of vitamin C supplementation on serum concentrations of total cholesterol, HDL- and LDL-cholesterol, and triacylglycerol was observed, although high-dose vitamin C supplementation increased serum vitamin C concentrations substantially. Among women, the mean change in serum triacylglycerol decreased (-0.12 mmol/l, 95 % CI -0.32, 0.09) in the high-dose group, but increased (+0.12 mmol/l, 95 % CI 0.03, 0.22) in the low-dose group. In addition, the mean change in serum triacylglycerol among women with hypertriacylglycerolaemia was statistically significant (-1.21, 95 % CI -2.38, -0.05) after high-dose vitamin C supplementation. The 5-year vitamin C supplementation had no markedly favourable effects on the serum lipid and lipoprotein profile. However, our present results do not preclude the possibility that vitamin C supplementation may decrease triacylglycerol concentrations among women with hypertriacylglycerolaemia.
Kim
Mi Kyung
MK
Department of Preventive Medicine, The Catholic University of Korea, Seoul, Korea.
Sasaki
Satoshi
S
Sasazuki
Shizuka
S
Okubo
Shunji
S
Hayashi
Masato
M
Tsugane
Shoichiro
S
D000328:Adult; D000368:Aged; D001205:Ascorbic Acid / Q000008:administration & dosage* / Q000097:blood; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D002908:Chronic Disease; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005757:Gastritis, Atrophic / Q000178:diet therapy; D006801:Humans; D015228:Hypertriglyceridemia / Q000517:prevention & control; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D012907:Smoking; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D001205:Ascorbic Acid