[Research concerning rutin semisynthetic derivatives, synthesis and pharmaco-toxicological properties of some new morpholine and piperidine derivatives].
In order to continue the research of the rutin semisynthetic derivatives we obtained some new morpholine and piperidine derivatives. Melting points, solubility, yield, C, H, N elemental analysis and UV spectra characterised all of these compounds. The toxicity was established by intraperitoneal administration at mice; the values of LD50 are between 743.75 and 856.25 mg/kg (medium toxicity). Pharmacological assays included the following parameters: leukocytes formula, NBT test, and serum complement activity. The new derivatives of rutin have a very good solubility in water, a pH closed to physiological value and immunosuppressive activity: peripheric blood PMN and lymphocytes are decreased; fagocytic capacity of peripheric blood PMN is also decreased; serum complement activity is not changed.
Lupaşcu
D
D
Disciplina de Chimie farmaceutică, Facultatea de Farmacie, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
Lupuşoru
Cătălina-Elena
CE
Dănilă
Gh
G
Ghiciuc
Cristina
C
Albu
Elena
E
Diaconu
C
C
Antonesei
Ioana
I
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000633:toxicity; D007274:Injections, Intraperitoneal; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D023421:Models, Animal; D009025:Morpholines / Q000494:pharmacology* / Q000633:toxicity; D009504:Neutrophils / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012431:Rutin / Q000494:pharmacology* / Q000633:toxicity
D002121:Calcium Channel Blockers; D009025:Morpholines; D010880:Piperidines; D012431:Rutin; C032727:piperidine; C037574:morpholine