Parallel nucleic acid recognition by the LNA (locked nucleic acid) stereoisomers beta-L-LNA and alpha-D-LNA; studies in the mirror image world.
Two LNA (locked nucleic acid) stereoisomers (beta-L-LNA and alpha-D-LNA) are evaluated in the mirror-image world, that is by the study of two mixed sequences of LNA and alpha-L-LNA and their L-DNA and L-RNA complements. Both are found to display high-affinity RNA-recognition by the formation of duplexes with parallel strand orientation.
Christensen
Nanna K
NK
Nucleic Acid Center, Department of Chemistry, University of Southern Denmark, DK-5230 Odense, Denmark.
Bryld
Torsten
T
Sørensen
Mads D
MD
Arar
Khalil
K
Wengel
Jesper
J
Nielsen
Poul
P
D001483:Base Sequence; D002942:Circular Dichroism; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D013237:Stereoisomerism
D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; C477371:locked nucleic acid; D012313:RNA