Total synthesis of the proposed structures of indole alkaloids lyaline and lyadine.
The harman-1,4-dihydropyridines 1 and 2, which constitute the originally proposed structures for the indole alkaloids lyaline and lyadine, have been synthesized, and their NMR data have been compared with those available for the natural products. Due to the discrepancies in the spectral data, the structures of lyadine and lyaline should be revised.
Bennasar
M-Lluïsa
ML
Laboratory of Organic Chemistry, Faculty of Pharmacy, University of Barcelona, 08028 Barcelona, Spain. bennasar@ub.edu
Roca
Tomàs
T
Monerris
Manuel
M
D026121:Indole Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D008094:Lithium / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D019666:Rubiaceae / Q000737:chemistry
D026121:Indole Alkaloids; D009942:Organometallic Compounds; D011725:Pyridines; C485020:lyadine; C485019:lyaline; D008094:Lithium