Taraxer-14-en-3beta-ol, an anti-inflammatory compound from Sterculia foetida L.
Taraxer-14-en-3beta-ol ( 1) was shown to be the active ingredient in the leaves of Sterculia foetida L. The alcohol 1, its acetate and ketone showed anti-inflammatory activity against TPA induced mouse ear oedema with inhibition ratios of 60.0, 58.57 and 40.57 at 0.5 mg/ear, respectively. The percentage inhibition of inflammation increased with dose for each compound.
Naik
D G
DG
Agharkar Research Institute, Pune, India. dgnpune@yahoo.co.in
Mujumdar
A M
AM
Waghole
R J
RJ
Misar
A V
AV
Bligh
S W
SW
Bashall
Alan
A
Crowder
John
J
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D051379:Mice; D009828:Oleanolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves; D032361:Sterculia
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D009828:Oleanolic Acid; C005802:taraxerol