title: Corpora amylacea in temporal lobe epilepsy associated with hippocampal sclerosis.
abstract: Hippocampal sclerosis (HS) is the commonest pathology in epileptic patients undergoing temporal lobe epilepsy surgery. Beside, there are an increased density of corpora amylacea (CA) founded in 6 to 63% of those cases.
  
  
  OBJECTIVE
  verify the presence of CA and the clinical correlates of their occurrence in a consecutive series of patients undergoing temporal surgery with diagnosis of HS.
  
  
  METHODS
  We reviewed 72 hippocampus specimens from January 1997 to July 2000. Student's t test for independent, samples, ANOVA and Tukey test were performed for statistical analysis.
  
  
  RESULTS
  CA were found in 35 patients (49%), whose mean epilepsy duration (28.7 years) was significantly longer than that group of patients without CA (19.5 years, p=0.001). Besides, when CA were found, duration was also significantly correlated with distribution within hippocampus: 28.7 years with diffuse distribution of CA, 15.4 with exclusively subpial and 17.4 years with distribution subpial plus perivascular (p=0.001).
  
  
  CONCLUSIONS
  Our findings corroborate the presence of CA in patients with HS and suggest that a longer duration of epilepsy correlate with a more distribution of CA in hippocampus.
authors.affiliation: Porto Alegre Epilepsy Surgery Program, Hospital São Lucas, Pontificia Universidade Católica, Porto Alegre, RS, Brazil.
authors.forename: Marlise de Castro
authors.initials: Mde C
authors.lastname: Ribeiro
authors.forename: Lígia
authors.initials: L
authors.lastname: Barbosa-Coutinho
authors.forename: Fabiana
authors.initials: F
authors.lastname: Mugnol
authors.forename: Arlete
authors.initials: A
authors.lastname: Hilbig
authors.forename: André
authors.initials: A
authors.lastname: Palmini
authors.forename: Jaderson Costa
authors.initials: JC
authors.lastname: da Costa
authors.forename: Eliseu
authors.initials: E
authors.lastname: Paglioli Neto
authors.forename: Eduardo
authors.initials: E
authors.lastname: Paglioli
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000681:Amylases / Q000032:analysis; D000704:Analysis of Variance; D002648:Child; D002675:Child, Preschool; D004833:Epilepsy, Temporal Lobe / Q000473:pathology* / Q000601:surgery; D005260:Female; D006624:Hippocampus / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D002479:Inclusion Bodies / Q000737:chemistry / Q000473:pathology*; D007223:Infant; D008297:Male; D012598:Sclerosis
chemical_list: D000681:Amylases