Elevated P/Q type (alpha1A) and L2 type (alpha1D) Purkinje cell voltage-gated calcium channels in the cerebella of seizure prone gerbils.
Differences in expression of N-methyl-D-aspartate (NMDA) receptor and voltage gated Ca2+ channels (VGCC) in the gerbil cerebellum were investigated to identify routes of Ca2+ influx that may be involved in Purkinje cell damage. Immunodensities of NR1 and NR2A/B were the same in seizure resistant (SR) and seizure sensitive (SS) gerbils. However, both P/Q type (alpha1A) and L2 type (alpha1D) VGCC levels were higher in the Purkinje cells of SS gerbils than in those of SR gerbils, whereas N type (alpha1B) and L1 type (alpha1C) VGCC levels were similar in the two groups. Our findings suggest that increases in P/Q type (alpha1A) and L2 type (alpha1D) VGCC are implicated in the degeneration of Purkinje cells in SS gerbils.
Park
Seung-Kook
SK
Department of Anatomy, College of Medicine, Hallym University, Chunchon 200-702, Korea.
Hwang
In Koo
IK
An
Sung-Jin
SJ
Won
Moo Ho
MH
Kang
Tae-Cheon
TC
D000818:Animals; D015220:Calcium Channels / Q000276:immunology / Q000378:metabolism*; D002531:Cerebellum / Q000276:immunology / Q000378:metabolism*; D005849:Gerbillinae / Q000276:immunology / Q000378:metabolism*; D015151:Immunoblotting; D007150:Immunohistochemistry; D011689:Purkinje Cells / Q000276:immunology / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology
D015220:Calcium Channels; D016194:Receptors, N-Methyl-D-Aspartate