Effective accumulation of polyion complex micelle to experimental choroidal neovascularization in rats.
Exudative age-related macular degeneration, characterized by choroidal neovascularization (CNV), is a major cause of visual loss. In this study, we examined the distribution of the polyion complex (PIC) micelle encapsulating FITC-P(Lys) in blood and in experimental CNV in rats to investigate whether PIC micelle can be used for treatment of CNV. We demonstrate that PIC micelle has long-circulating characteristics, accumulating to the CNV lesions and is retained in the lesion for as long as 168 h after intravenous administration. These results raise the possibility that PIC micelles can be used for achieving effective drug targeting to CNV.
Ideta
Ryuichi
R
Department of Ophthalmology, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Yanagi
Yasuo
Y
Tamaki
Yasuhiro
Y
Tasaka
Fumitaka
F
Harada
Atsushi
A
Kataoka
Kazunori
K
D000818:Animals; D002829:Choroid / Q000098:blood supply* / Q000473:pathology; D020256:Choroidal Neovascularization / Q000473:pathology*; D004195:Disease Models, Animal; D008268:Macular Degeneration / Q000473:pathology; D008297:Male; D008823:Micelles; D051381:Rats; D011914:Rats, Inbred BN; D012160:Retina / Q000473:pathology
D008823:Micelles