title: Stroke magnetic resonance imaging is accurate in hyperacute intracerebral hemorrhage: a multicenter study on the validity of stroke imaging.
abstract: OBJECTIVE
  Although modern multisequence stroke MRI protocols are an emerging imaging routine for the diagnostic assessment of acute ischemic stroke, their sensitivity for intracerebral hemorrhage (ICH), the most important differential diagnosis, is still a matter of debate. We hypothesized that stroke MRI is accurate in the detection of ICH. To evaluate our hypotheses, we conducted a prospective multicenter trial.
  
  
  METHODS
  Stroke MRI protocols of 6 university hospitals were standardized. Images from 62 ICH patients and 62 nonhemorrhagic stroke patients, all imaged within the first 6 hours after symptom onset (mean, 3 hours 18 minutes), were analyzed. For diagnosis of hemorrhage, CT served as the "gold standard." Three readers experienced in stroke imaging and 3 final-year medical students, unaware of clinical details, separately evaluated sets of diffusion-, T2-, and T2*-weighted images. The extent and phenomenology of the hemorrhage on MRI were assessed separately.
  
  
  RESULTS
  Mean patient age was 65.5 years; median National Institutes of Health Stroke Scale score was 10. The experienced readers identified ICH with 100% sensitivity (confidence interval, 97.1 to 100) and 100% overall accuracy. Mean ICH size was 17.3 mL (range, 1 to 101.5 mL). The students reached a mean sensitivity of 95.16% (confidence interval, 90.32 to 98.39).
  
  
  CONCLUSIONS
  Hyperacute ICH causes a characteristic imaging pattern on stroke MRI and is detectable with excellent accuracy. Even raters with limited film-reading experience reached good accuracy. Stroke MRI alone can rule out ICH and demonstrate the underlying pathology in hyperacute stroke.
authors.affiliation: Department of Neuroradiology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany. Jochen_Fiebach@med.uni-heidelberg.de
authors.forename: Jochen B
authors.initials: JB
authors.lastname: Fiebach
authors.forename: Peter D
authors.initials: PD
authors.lastname: Schellinger
authors.forename: Achim
authors.initials: A
authors.lastname: Gass
authors.forename: Thomas
authors.initials: T
authors.lastname: Kucinski
authors.forename: Mario
authors.initials: M
authors.lastname: Siebler
authors.forename: Arno
authors.initials: A
authors.lastname: Villringer
authors.forename: Peter
authors.initials: P
authors.lastname: Olkers
authors.forename: Jochen G
authors.initials: JG
authors.lastname: Hirsch
authors.forename: Sabine
authors.initials: S
authors.lastname: Heiland
authors.forename: Philipp
authors.initials: P
authors.lastname: Wilde
authors.forename: Olav
authors.initials: O
authors.lastname: Jansen
authors.forename: Joachim
authors.initials: J
authors.lastname: Röther
authors.forename: Werner
authors.initials: W
authors.lastname: Hacke
authors.forename: Klaus
authors.initials: K
authors.lastname: Sartor
mesh_terms: D000208:Acute Disease; D000368:Aged; D002543:Cerebral Hemorrhage / Q000150:complications / Q000175:diagnosis*; D015331:Cohort Studies; D005260:Female; D005858:Germany; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D018401:Sample Size; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed