Association between tumor necrosis factor-alpha promoter polymorphism and Alzheimer's disease.
Tumor necrosis factor-alpha (TNFalpha) gene polymorphisms have been reported to be associated with Alzheimer's disease (AD) in Caucasian populations. Three TNFalpha polymorphisms (-857, -863, and -1,031) were studied in a Chinese population. A high-risk TNFalpha haplotype (-1,031C-863C-857C) with an odds ratio of 2.54 (95% CI 1.37 to 4.79) for AD was identified. No interaction effect of APOE and TNFalpha genotypes was found, but both acted as important risk factors for AD.
Ma
Suk Ling
SL
Department of Chemical Pathology, Faculty of Medicine, Chinese University of Hong Kong, Shatin, China.
Tang
Nelson L S
NL
Lam
Linda C W
LC
Chiu
Helen F K
HF
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D012306:Risk; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D001057:Apolipoproteins E; D014409:Tumor Necrosis Factor-alpha