title: QSAR analysis of antibacterial activity of some 4-aminodiphenylsulfone derivatives.
abstract: QSAR studies on a set of 36 congeners of 4-aminodiphenylsulfone derivatives with measured inhibition potencies of dihydropterate synthase were made using multiple regression analysis. Conformational entropy in combination with indicator parameters gave excellent results.
authors.affiliation: Department of Chemistry, A. P. S. University, Rewa 486 003, India. vijay-agrawal@lycos.com
authors.forename: V K
authors.initials: VK
authors.lastname: Agrawal
authors.forename: S
authors.initials: S
authors.lastname: Bano
authors.forename: P V
authors.initials: PV
authors.lastname: Khadikar
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D003622:Dapsone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D004094:Dihydropteroate Synthase / Q000037:antagonists & inhibitors; D016984:Enterococcus faecium / Q000187:drug effects / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D005492:Folic Acid / Q000096:biosynthesis; D008968:Molecular Conformation; D021281:Quantitative Structure-Activity Relationship; D013816:Thermodynamics
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D003622:Dapsone; D005492:Folic Acid; D004094:Dihydropteroate Synthase