Abnormal uterine bleeding as a presentation of metastatic breast disease in a patient with advanced breast cancer on tamoxifen therapy.
BACKGROUND
Extra pelvic tumours rarely metastasise to the female genital tract. Typically it is the ovaries that are involved and the primary tumours include the breast and the gastrointestinal tract. Metastatic disease involving the uterus is rare.


METHODS
A case of metastatic breast carcinoma involving both the uterine corpus and cervix is described. The patient was known to have advanced breast carcinoma and was on tamoxifen therapy when she presented with postmenopausal bleeding. Histological assessment of the hysterectomy specimen including immunohistochemistry staining confirmed the breast carcinoma as the primary.


CONCLUSIONS
Unusual uterine bleeding in a patient with breast cancer, should alert the gynaecologist to the possibility of metastatic breast disease regardless of tamoxifen treatment.
Famoriyo
Akin
A
Glan Clwyd Hospital, Sarn Lane, Bodelwyddan, North Wales, UK. famo@fsmail.net
Sawant
Sangeeta
S
Banfield
Phillip J
PJ
D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D018275:Carcinoma, Lobular / Q000150:complications / Q000175:diagnosis* / Q000556:secondary; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D013629:Tamoxifen; D014592:Uterine Hemorrhage / Q000209:etiology; D014594:Uterine Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000556:secondary
D013629:Tamoxifen