[Study of the cardiovascular properties of some new methyl-xanthine derivatives].
The effects of some new methylxanthine compounds, derivatives of theophylline, theobromine and caffeine with various radicals in 8 position on blood pressure have been studied. Derivatives of theophylline (1,3-dimethyl-xanthine) with various radicals in 8 position have reduced the blood pressure. In the same experimental conditions the theobromine (3,7-dimethyl-xanthine) derivatives haven't modified the blood pressure while the caffeine (1,3,7-trimethyl-xanthine) derivatives have increased the blood pressure values.
Profire
Lenuţa
L
Disciplina de Chimie Farmaceutică, Facultatea de Farmacie, Universitatea de Medicină şi Farmacie Gr.T. Popa Iaşi.
Dănilă
Gh
G
Nechifor
M
M
D000465:Algorithms; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002110:Caffeine / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013805:Theobromine / Q000494:pharmacology; D013806:Theophylline / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology; D014970:Xanthines / Q000494:pharmacology*
D000697:Central Nervous System Stimulants; D014665:Vasodilator Agents; D014970:Xanthines; C008514:methylxanthine; D002110:Caffeine; D013806:Theophylline; D013805:Theobromine