The alpha 1D-adrenergic receptor modulates cardiovascular and drinking responses to central salt loading in mice.
To characterize the involvement of specific alpha(1)-adrenergic receptor (alpha(1)-AR) subtypes in hypertension, parameters related to central salt- or angiotensin II (ANG II)-induced hypertension were investigated in alpha(1D)-AR-deficient mice (knockout). Baseline daily water intake and food intake were larger in alpha(1D)(-/-) mice than in alpha(1D)(+/+) mice. Intracerebroventricular (i.c.v.) administration of NaCl (0.67 M NaCl, 1 microl) elicited smaller increases in mean arterial blood pressure (MABP), heart rate, and water intake in alpha(1D)(-/-) mice than it did in alpha(1D)(+/+) mice. I.c.v. administration of ANG II (10 pmol) resulted in increases in MABP and water intake that were similar in alpha(1D)(-/-) mice and alpha(1D)(+/+) mice. These results suggest that alpha(1D)-AR is, at least in part, involved in central salt-induced but not ANG II-induced hypertension and water intake.
Chu
Chun-Ping
CP
Department of Physiology, Miyazaki Medical College, 5200 Kihara, Kiyotake-cho, Miyazaki-gun, Miyazaki 889-1692, Japan.
Kunitake
Takato
T
Kato
Kazuo
K
Watanabe
Shoichi
S
Qiu
De-Lai
DL
Tanoue
Akito
A
Kannan
Hiroshi
H
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D002319:Cardiovascular System / Q000187:drug effects / Q000378:metabolism; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D018340:Receptors, Adrenergic, alpha-1 / Q000502:physiology*; D017673:Sodium Chloride, Dietary / Q000494:pharmacology*
C547720:Adra1d protein, mouse; D018340:Receptors, Adrenergic, alpha-1; D017673:Sodium Chloride, Dietary; D000804:Angiotensin II