[Combined effect of vilon and cyclophosphane on tumor transplants and lymphoid tissue explants in mice and rats of various age].
The experiments were performed in mice with transplanted Lewis lung carcinoma. The injections of synthetic peptide vilon at the doses 1 mg/kg significantly increased the survival of mice. So vilon has possessed the oncomodulating action on the transplanted carcinoma. The synchronous injection both of vilon and cyclophosphan at the doses 100 mg/kg decreases the survival of mice. There was also studied in spleen organotypic tissue culture the effect of vilon and cyclophosphan on the development of explants of rats of various age: 1 day and 2 years old. Vilon stimulated apoptosis both in young and old rats, but the inhibitory effect of cyclophosphan was abolished in the presence of vilon in culture media at the dose 5 ng/ml. The results obtained suggested that perspective preparates in the cancer therapy--vilon and cytostatic drugs-, must be used not synchronously.
Barykina
O P
OP
St. Petersburg Institute of Bioregulation and Gerontology of the North-Western Branch, Russian Academy of Medical Sciences, 3, Dinamo Prospect, 197110, St. Petersburg, Russia.
Iuzhakov
V V
VV
Chalisova
N I
NI
Kvetnoĭ
I M
IM
Konovalov
S S
SS
D000375:Aging / Q000473:pathology*; D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy* / Q000473:pathology; D003470:Culture Media; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D004151:Dipeptides / Q000008:administration & dosage / Q000494:pharmacology; D004336:Drug Antagonism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009924:Organ Culture Techniques; D051381:Rats; D013154:Spleen / Q000187:drug effects*
D003470:Culture Media; D004151:Dipeptides; D003520:Cyclophosphamide; C415909:lysylglutamic acid