title: Effect of an "all-in-one" adhesive on pulp blood vessels: a vitalmicroscopic study of rat's teeth.
abstract: The newly developed self-etching, self-priming all-in-one adhesives are appealing to clinicians because they are simple and efficient to use. These single-application bonding systems contain chemically active compounds that can alter pulpal blood circulation when applied to deep dentin surfaces. Since adequate microcirculation and oxygenation are the basic requirements for tissue survival, the aim of this study was to investigate the immediate vascular effect of a new self-etching adhesive, Prompt L-Pop/composite and compomer version/(test group). The technique of vitalmicroscopy was used to record the changes in vessel diameter of the first lower incisor of 20 (10-10 in each group) male Sprague-Dawley rats (weighing 315 +/- 74/SE/g) prior to, and at 5, 15, 30 and 60 minutes after the investigated materials were applied to dentin. The application of saline served as the untreated control. The systemic arterial pressure remained unchanged throughout the experiments both in the control (110 +/- 8 mmHg) and in test animals (114 +/- 4 mmHg). In control rats, the diameter of the vessels was stable during the experiment. In the presence of Prompt L-Pop, the diameters decreased significantly during the experimental period (5 minutes: -11.15 +/- 5.03%; 15 minutes: -14.66 +/- 7.71%; 30 minutes: -13.35 +/- 5.79%; 60 minutes: -11.82 +/- 5.63% p < 0.05 in each cases). In this group, stasis developed in pulpal circulation was 1 out of 10 rats. The results from the rat model used in this study suggest that Prompt L-Pop may result in compromised pulpal microcirculation.
authors.affiliation: Semmelweis University, Faculty of Dentistry, Department of Prosthodontics, Budapest, Hungary. kispelyi@freemail.hu
authors.forename: Barbara
authors.initials: B
authors.lastname: Kispélyi
authors.forename: László
authors.initials: L
authors.lastname: Fejérdy
authors.forename: Iván
authors.initials: I
authors.lastname: Iványi
authors.forename: László
authors.initials: L
authors.lastname: Rosivall
authors.forename: Ida
authors.initials: I
authors.lastname: Nyárasdy
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D020770:Compomers / Q000494:pharmacology; D003188:Composite Resins / Q000494:pharmacology; D003782:Dental Pulp / Q000098:blood supply* / Q000187:drug effects; D017220:Dentin-Bonding Agents / Q000145:classification / Q000494:pharmacology*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008853:Microscopy; D023421:Models, Animal; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000187:drug effects; D019279:Resin Cements / Q000494:pharmacology; D018709:Statistics, Nonparametric; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000494:pharmacology
chemical_list: D020770:Compomers; D003188:Composite Resins; D017220:Dentin-Bonding Agents; C408584:Prompt L-Pop; D019279:Resin Cements; D014662:Vasoconstrictor Agents