Dynamics of pinned membranes with application to protein diffusion on the surface of red blood cells.
We present a theoretical treatment and simulation algorithm for the dynamics of Helfrich elastic membrane surfaces in the presence of general harmonic perturbations and hydrodynamic coupling to the surrounding solvent. In the limit of localized and strong interactions, this harmonic model can be used to pin the membrane to intracellular/intercellular structures. We consider the case of pinning to the cytoskeleton and use such a model to estimate the macroscopic diffusion constant for band 3 protein on the surface of human erythrocytes. Comparison to experimental results suggests that thermal undulations of the membrane surface should play a significant role in protein mobility on the red blood cell.
Lin
Lawrence C-L
LC
Department of Physics, University of California, Santa Barbara, California 93106-9510, USA.
Brown
Frank L H
FL
D000327:Adsorption; D000465:Algorithms; D001457:Anion Exchange Protein 1, Erythrocyte / Q000737:chemistry*; D003198:Computer Simulation; D003599:Cytoskeleton / Q000737:chemistry*; D004058:Diffusion; D004910:Erythrocyte Membrane / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008560:Membrane Fluidity; D008954:Models, Biological; D008956:Models, Chemical; D009038:Motion
D001457:Anion Exchange Protein 1, Erythrocyte; D008051:Lipid Bilayers