title: Lysosome and lysosome-related organelles responsible for specialized functions in higher organisms, with special emphasis on vacuolar-type proton ATPase.
abstract: Mammals contain various cells differentiated in both morphology and function, which play vital roles in tissue-specific functions. Late endosome/lysosome and lysosomal-related organelles are involved in these specialized functions including antigen presentation, bone remodeling and hormone regulation. To fulfill these diverse roles, lysosomes are present at different levels in different tissues and cell types; however, their morphology within these different tissues varies and the regulation of their activities differs with lysosomal compartments in some cells also functioning as secretory compartments. The luminal acidification of these organelles is closely correlated with their functions. This review will discuss the functions of lysosomes and lysosomal-related organelles, with particular emphasis on the major proton pump, the vacuolar-type proton ATPase (V-ATPase), which is responsible for luminal acidification.
authors.affiliation: Division of Biological Sciences and Nanoscience, Japan Science and Technology Cooperation, Institute of Scientific and Industrial Research, Osaka University, Mihogaoka 8-1, Ibaraki, Osaka 567-0047, Japan. sunwada@sanken.osaka-u.ac.jp
authors.forename: Ge-Hong
authors.initials: GH
authors.lastname: Sun-Wada
authors.forename: Yoh
authors.initials: Y
authors.lastname: Wada
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Futai
mesh_terms: D000177:Acrosome / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000166:cytology / Q000378:metabolism; D008168:Lung / Q000166:cytology / Q000378:metabolism; D051907:Lysosomal Membrane Proteins; D008247:Lysosomes / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D010010:Osteoclasts / Q000378:metabolism; D021122:Protein Subunits / Q000378:metabolism; D013094:Spermatozoa / Q000166:cytology / Q000378:metabolism; D025262:Vacuolar Proton-Translocating ATPases / Q000737:chemistry / Q000378:metabolism*; D014617:Vacuoles / Q000378:metabolism*
chemical_list: D015703:Antigens, CD; D051907:Lysosomal Membrane Proteins; D021122:Protein Subunits; D025262:Vacuolar Proton-Translocating ATPases