Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves.
A new derivative of strychnopentamine was isolated from the leaves of Strychnos usambarensis. This compound, named chrysopentamine, was identified by detailed spectroscopic methods (UV, IR, HR-ESI-MS, 1D and 2D NMR). Chrysopentamine presented an original hydroxy substitution on C-14 and an aromatization of the ring D of strychnopentamine leading to anhydronium base properties and exhibited strong antiplasmodial properties (IC (50) less than 1 microM).
Frédérich
Michel
M
Division of Pharmacognosy, Section Metabolomics, Institute of Biology, Leiden University, Leiden, The Netherlands. M.Frederich@ulg.ac.be
Cristino
Assunção
A
Choi
Young Hae
YH
Verpoorte
Robert
R
Tits
Monique
M
Angenot
Luc
L
Prost
Elise
E
Nuzillard
Jean-Marc
JM
Zèches-Hanrot
Monique
M
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D021261:Parasitic Sensitivity Tests; D008517:Phytotherapy; D018515:Plant Leaves; D010963:Plasmodium falciparum / Q000187:drug effects*; D011759:Pyrrolidines / Q000737:chemistry / Q000494:pharmacology*; D031451:Strychnos
D000962:Antimalarials; D006576:Heterocyclic Compounds, 4 or More Rings; D011759:Pyrrolidines; C483064:chrysopentamine